>SAP_HUMAN (P07602) Proactivator polypeptide precursor [Contains: Saposin A|
           (Protein A); Saposin B-Val; Saposin B (Sphingolipid
           activator protein 1) (SAP-1) (Cerebroside sulfate
           activator) (CSAct) (Dispersin) (Sulfatide/GM1
           activator); Saposin C (Co-beta-
          Length = 524

 Score = 33.5 bits (75), Expect = 0.33
 Identities = 14/60 (23%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
 Frame = +2

Query: 317 CPACEKFTNEALSYLGQKQSQDKMMEVLHEACSQT-FSLEKKCVELVDSYATLLFAKIAE 493
           C  CE    E    +   +++ ++++   + CS+   SL ++C E+VD+Y + + + + E
Sbjct: 315 CEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLE 374

>DBP4_EMENI (Q5BFU1) ATP-dependent RNA helicase dbp4 (EC 3.6.1.-)|
          Length = 812

 Score = 33.5 bits (75), Expect = 0.33
 Identities = 25/93 (26%), Positives = 47/93 (50%), Gaps = 2/93 (2%)
 Frame = +2

Query: 200 GRGTVFLDNEQEARASGQIIKDQLTLSKIPVRVERGSPLCPACEK--FTNEALSYLGQKQ 373
           GR  +FLD  +E     ++ + ++T+ +I VR  +   +    +   F +  L YLGQK 
Sbjct: 392 GRAVLFLDPSEEKGMLRRLEQKRVTVERINVRANKQQSIKNQLQNMCFKDPELKYLGQKA 451

Query: 374 SQDKMMEVLHEACSQTFSLEKKCVELVDSYATL 472
               +  V  +   +TF+L++  ++L D  A+L
Sbjct: 452 FISYVKSVYIQKDKETFNLKE--LKLDDFAASL 482

>SAP_BOVIN (P26779) Proactivator polypeptide precursor [Contains: Saposin A|
           (Protein A); Saposin B (Sphingolipid activator protein
           1) (SAP-1) (Cerebroside sulfate activator) (CSAct)
           (Dispersin) (Sulfatide/GM1 activator); Saposin C
           (Co-beta-glucosidase) (A
          Length = 525

 Score = 33.5 bits (75), Expect = 0.33
 Identities = 14/50 (28%), Positives = 28/50 (56%), Gaps = 1/50 (2%)
 Frame = +2

Query: 317 CPACEKFTNEALSYLGQKQSQDKMMEVLHEACSQ-TFSLEKKCVELVDSY 463
           C  CE    E    +   +++++++  L + CS+   SL ++C E+VD+Y
Sbjct: 316 CEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTY 365

>SAP_MOUSE (Q61207) Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin)|
          Length = 557

 Score = 32.7 bits (73), Expect = 0.56
 Identities = 17/59 (28%), Positives = 28/59 (47%), Gaps = 2/59 (3%)
 Frame = +2

Query: 317 CPACEKFTNEALSYLGQKQSQDKMMEVLHEACS--QTFSLEKKCVELVDSYATLLFAKI 487
           C  C+    EA + L    +Q++++  L + C      SL   C E+VDSY  ++   I
Sbjct: 63  CDICKTVVTEAGNLLKDNATQEEILHYLEKTCEWIHDSSLSASCKEVVDSYLPVILDMI 121

>SAP_CAVPO (P20097) Saposin C (CO-beta-glucosidase) (Glucosylceramidase|
           activator) (Sphingolipid activator protein 2) (SAP-2)
          Length = 81

 Score = 32.7 bits (73), Expect = 0.56
 Identities = 15/63 (23%), Positives = 32/63 (50%), Gaps = 1/63 (1%)
 Frame = +2

Query: 308 SPLCPACEKFTNEALSYLGQKQSQDKMMEVLHEACS-QTFSLEKKCVELVDSYATLLFAK 484
           S  C ACE    + +  +   ++++K++  L   C+    S+ + C E+VD+Y   + A 
Sbjct: 2   SVTCKACEYVVKKVMELIDNNRTEEKIIHALDSVCALLPESVSEVCQEVVDTYGDSIVAL 61

Query: 485 IAE 493
           + +
Sbjct: 62  LLQ 64

>SAP_RAT (P10960) Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin)|
          Length = 554

 Score = 32.0 bits (71), Expect = 0.95
 Identities = 16/59 (27%), Positives = 29/59 (49%), Gaps = 2/59 (3%)
 Frame = +2

Query: 317 CPACEKFTNEALSYLGQKQSQDKMMEVLHEACS--QTFSLEKKCVELVDSYATLLFAKI 487
           C  C+    EA + L    ++++++  L + C+     SL   C E+VDSY  ++   I
Sbjct: 63  CDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIHDSSLSASCKEVVDSYLPVILDMI 121

>TRI46_MOUSE (Q7TNM2) Tripartite motif protein 46 (Tripartite, fibronectin|
           type-III and C-terminal SPRY motif protein)
          Length = 759

 Score = 30.8 bits (68), Expect = 2.1
 Identities = 37/117 (31%), Positives = 51/117 (43%), Gaps = 12/117 (10%)
 Frame = -3

Query: 321 GHSGLPLSTRTGILLKVS*SLMI*PDARASCSLSRKTVPRPCALPRLTSS----KRSRQK 154
           GH G P S  T        S    P  R S  LSR+T+P+P  L RL  S       R++
Sbjct: 68  GHGGDPSSEPT--------SPASTPSTR-SPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR 118

Query: 153 GNLSPKPIAREVPTL--TLRLGNRA-----RSRREEQVVVRLGRP-DLFSAFVCRVC 7
           G L P+ I    P     + LG R      R+   E+VV R  +   +  A +C++C
Sbjct: 119 GALHPQTILFPCPACQGDVELGERGLSGLFRNLTLERVVERYRQSVSVGGAILCQLC 175

>MYSH_ACACA (P47808) High molecular weight form of myosin-1 (High molecular|
            weight form of myosin I) (HMWMI)
          Length = 1577

 Score = 30.4 bits (67), Expect = 2.8
 Identities = 22/59 (37%), Positives = 29/59 (49%), Gaps = 7/59 (11%)
 Frame = +2

Query: 251  QIIKDQLTLSKIPVRVERGSPLCPAC-------EKFTNEALSYLGQKQSQDKMMEVLHE 406
            QIIK QLT +  P  V +G  L   C       E+F N    +L  K   DK +E+LH+
Sbjct: 1324 QIIK-QLTENPSPQSVTKGWQLMRCCLQTFPPSEEFANCLEMFLAAKGKDDKYIEMLHD 1381

>TRI46_HUMAN (Q7Z4K8) Tripartite motif protein 46 (Tripartite, fibronectin|
           type-III and C-terminal SPRY motif protein)
          Length = 759

 Score = 30.4 bits (67), Expect = 2.8
 Identities = 37/117 (31%), Positives = 51/117 (43%), Gaps = 12/117 (10%)
 Frame = -3

Query: 321 GHSGLPLSTRTGILLKVS*SLMI*PDARASCSLSRKTVPRPCALPRLTSS----KRSRQK 154
           GH G P S  T        S    P  R S  LSR+T+P+P  L RL  S       R++
Sbjct: 68  GHGGDPSSEPT--------SPASTPSTR-SPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR 118

Query: 153 GNLSPKPIAREVPTL--TLRLGNRA-----RSRREEQVVVRLGRP-DLFSAFVCRVC 7
           G L P+ I    P     + LG R      R+   E+VV R  +   +  A +C++C
Sbjct: 119 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLC 175

>JPH1_HUMAN (Q9HDC5) Junctophilin-1 (Junctophilin type 1) (JP-1)|
          Length = 661

 Score = 30.0 bits (66), Expect = 3.6
 Identities = 25/73 (34%), Positives = 35/73 (47%), Gaps = 3/73 (4%)
 Frame = -3

Query: 249 PDARASCSLSRK--TVPR-PCALPRLTSSKRSRQKGNLSPKPIAREVPTLTLRLGNRARS 79
           P  + S    RK  T PR P A P+ + S  S      SPKP+ ++ P+   RL    RS
Sbjct: 447 PTPKESPHFYRKGTTPPRSPEASPKHSHSPAS------SPKPLKKQNPSSGARLNQDKRS 500

Query: 78  RREEQVVVRLGRP 40
             +EQV   + +P
Sbjct: 501 VADEQVTAIVNKP 513

>DOK3_HUMAN (Q7L591) Docking protein 3 (Downstream of tyrosine kinase 3)|
          Length = 496

 Score = 30.0 bits (66), Expect = 3.6
 Identities = 18/44 (40%), Positives = 19/44 (43%)
 Frame = -3

Query: 243 ARASCSLSRKTVPRPCALPRLTSSKRSRQKGNLSPKPIAREVPT 112
           AR    L   T P+PC LPR TS       G L   P   E PT
Sbjct: 308 ARQRERLPELTRPQPCPLPRATSLPSLDTPGELREMPPGPEPPT 351

>R1AB_BSCR3 (Q3I5J6) Replicase polyprotein 1ab (pp1ab) (ORF1AB) [Includes:|
            Replicase polyprotein 1a (pp1a) (ORF1A)] [Contains:
            Leader protein; p65 homolog; NSP1 (EC 3.4.22.-)
            (Papain-like proteinase) (PL-PRO); 3C-like proteinase (EC
            3.4.22.-) (3CL-PRO) (3
          Length = 7071

 Score = 30.0 bits (66), Expect = 3.6
 Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
 Frame = +2

Query: 290  VRVERGSPLCPACEKFTNEALSYLGQKQSQDKMMEVLHEACSQ--TFSLEKKCVELVDSY 463
            +RVE  S L   C +  N+ L      ++ +KM+ +L    S      + K C E++D+ 
Sbjct: 3854 LRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNR 3913

Query: 464  ATL 472
            ATL
Sbjct: 3914 ATL 3916

>ASPR_HORVU (P42210) Phytepsin precursor (EC 3.4.23.40) (Aspartic proteinase)|
           [Contains: Phytepsin 32 kDa subunit; Phytepsin 29 kDa
           subunit; Phytepsin 16 kDa subunit; Phytepsin 11 kDa
           subunit]
          Length = 508

 Score = 30.0 bits (66), Expect = 3.6
 Identities = 11/39 (28%), Positives = 23/39 (58%)
 Frame = +2

Query: 302 RGSPLCPACEKFTNEALSYLGQKQSQDKMMEVLHEACSQ 418
           R  P+C ACE       + L Q ++QD +++ +++ C++
Sbjct: 377 RADPMCSACEMAVVWMQNQLAQNKTQDLILDYVNQLCNR 415

>Y1249_LEGPL (Q5WX49) UPF0082 protein lpl1249|
          Length = 247

 Score = 30.0 bits (66), Expect = 3.6
 Identities = 16/52 (30%), Positives = 30/52 (57%), Gaps = 3/52 (5%)
 Frame = +2

Query: 335 FTNEALSYLGQKQSQDKMMEVLHEACSQTFSLEKKCVEL---VDSYATLLFA 481
           FTN+    +   Q +DK+ME+  +A +   ++E   +E+   V++Y T+L A
Sbjct: 134 FTNQGEILMASNQPEDKVMEIAIDAGASDVAVEDSQIEIITPVEAYHTVLNA 185

>Y1249_LEGPA (Q5X5S1) UPF0082 protein lpp1249|
          Length = 247

 Score = 30.0 bits (66), Expect = 3.6
 Identities = 16/52 (30%), Positives = 30/52 (57%), Gaps = 3/52 (5%)
 Frame = +2

Query: 335 FTNEALSYLGQKQSQDKMMEVLHEACSQTFSLEKKCVEL---VDSYATLLFA 481
           FTN+    +   Q +DK+ME+  +A +   ++E   +E+   V++Y T+L A
Sbjct: 134 FTNQGEILMASNQPEDKVMEIAIDAGASDVAVEDSQIEIITPVEAYHTVLNA 185

>REEP4_BOVIN (Q3ZCI8) Receptor expression-enhancing protein 4|
          Length = 257

 Score = 30.0 bits (66), Expect = 3.6
 Identities = 17/56 (30%), Positives = 28/56 (50%)
 Frame = -3

Query: 246 DARASCSLSRKTVPRPCALPRLTSSKRSRQKGNLSPKPIAREVPTLTLRLGNRARS 79
           D    C    + VP+P A PR     RS+    +  KP+ARE  + +L++  R ++
Sbjct: 195 DTDNECWSDTEVVPQPPARPREKPLGRSQSLRVIKRKPLAREGTSRSLKVRTRKKT 250

>LYXK_PASMU (P57928) Probable L-xylulose kinase (EC 2.7.1.53) (L-xylulokinase)|
          Length = 483

 Score = 29.6 bits (65), Expect = 4.7
 Identities = 15/41 (36%), Positives = 21/41 (51%)
 Frame = +2

Query: 191 SAQGRGTVFLDNEQEARASGQIIKDQLTLSKIPVRVERGSP 313
           SAQG+G   LD E +    G +  DQ  L+ +    E+G P
Sbjct: 78  SAQGKGAFLLDQENKPLGRGILSSDQRALTLVKQWQEQGIP 118

>JPH1_MOUSE (Q9ET80) Junctophilin-1 (Junctophilin type 1) (JP-1)|
          Length = 660

 Score = 29.3 bits (64), Expect = 6.2
 Identities = 16/52 (30%), Positives = 26/52 (50%)
 Frame = -3

Query: 180 TSSKRSRQKGNLSPKPIAREVPTLTLRLGNRARSRREEQVVVRLGRPDLFSA 25
           +S K+S      SP+P  ++ P+   RL    +S  EEQV   + +P +  A
Sbjct: 468 SSPKQSHSPQPSSPEPSKKQNPSPGARLSQDKQSLAEEQVTAFVNKPSMSKA 519

>DBP4_ASPFU (Q4WM60) ATP-dependent RNA helicase dbp4 (EC 3.6.1.-)|
          Length = 787

 Score = 29.3 bits (64), Expect = 6.2
 Identities = 18/82 (21%), Positives = 38/82 (46%), Gaps = 2/82 (2%)
 Frame = +2

Query: 197 QGRGTVFLDNEQEARASGQIIKDQLTLSKIPVRVERGSPLCPACEK--FTNEALSYLGQK 370
           +GR  +FLD  +E     ++ + ++ + KI ++  +   +    +   F +  L YLGQK
Sbjct: 390 EGRAVLFLDPSEEEGMLKRLEQKKVPIEKINIKANKQQSIKDQLQNMCFKDPELKYLGQK 449

Query: 371 QSQDKMMEVLHEACSQTFSLEK 436
                +  V  +   + F L++
Sbjct: 450 AFISYVKSVYIQKDKEIFKLKE 471

>DBP4_NEUCR (Q7RZ35) ATP-dependent RNA helicase dbp-4 (EC 3.6.1.-)|
          Length = 823

 Score = 29.3 bits (64), Expect = 6.2
 Identities = 18/83 (21%), Positives = 38/83 (45%), Gaps = 2/83 (2%)
 Frame = +2

Query: 194 AQGRGTVFLDNEQEARASGQIIKDQLTLSKIPVRVERGSPLCPACEK--FTNEALSYLGQ 367
           ++GR  +FLD  +E     ++   ++T+ K+ V+  +   +    +   F +  L YLGQ
Sbjct: 399 SKGRAVLFLDPSEEEGFLKRLEHKKVTVQKVNVKENKKKSIKNELQSQCFQSPDLKYLGQ 458

Query: 368 KQSQDKMMEVLHEACSQTFSLEK 436
           K     +  +  +   + F  +K
Sbjct: 459 KAFVSYVRSIYLQKDKEVFKFDK 481

>Y1286_LEGPH (Q5ZW02) UPF0082 protein lpg1286|
          Length = 247

 Score = 29.3 bits (64), Expect = 6.2
 Identities = 16/52 (30%), Positives = 30/52 (57%), Gaps = 3/52 (5%)
 Frame = +2

Query: 335 FTNEALSYLGQKQSQDKMMEVLHEACSQTFSLEKKCVEL---VDSYATLLFA 481
           FTN+    +   Q +DK+ME+  +A +   ++E   +E+   V++Y T+L A
Sbjct: 134 FTNQGEILMASNQPEDKVMEIAIDAGASDVAVEDGQIEIITPVEAYHTVLNA 185

>MBN_DROME (P52302) Protein lethal(3)malignant blood neoplasm 1 (Mbn(83))|
          Length = 653

 Score = 29.3 bits (64), Expect = 6.2
 Identities = 23/68 (33%), Positives = 31/68 (45%), Gaps = 5/68 (7%)
 Frame = +1

Query: 4   YTYTTHKSRKKIRTTQTHHHLLLPAAACSIPQPQGQRGN-----LSRDGLRTEIALLSTP 168
           Y Y      K +  T T   +LLPAA  ++P+            L +   +TEI  LS P
Sbjct: 87  YPYAGPVGSKSVPVTTTPK-VLLPAAPVALPKYNFNSEACSGCFLKKSPPKTEIRTLSQP 145

Query: 169 LAARQPGE 192
           LA  QPG+
Sbjct: 146 LAPVQPGK 153

>PKN2_COREF (Q8FUI4) Serine/threonine protein kinases drp72 (EC 2.7.11.1)|
          Length = 520

 Score = 28.9 bits (63), Expect = 8.1
 Identities = 21/77 (27%), Positives = 28/77 (36%)
 Frame = +1

Query: 91  IPQPQGQRGNLSRDGLRTEIALLSTPLAARQPGERTRPGHSFS**RAGGSSIWSNHQGST 270
           +P P      L      +   +  TP    +PGE+T PG          S  W N+QG T
Sbjct: 407 VPTPDETPTRLPTTTQESPTRVSPTPEETDEPGEQTTPGGQPPLSTLPTSLGWQNNQGGT 466

Query: 271 NFEQNSRAC*EGQPTMP 321
             + N      G P  P
Sbjct: 467 GNQGNPNT--TGNPANP 481

>R1AB_CVHSA (P59641) Replicase polyprotein 1ab (pp1ab) (ORF1AB) [Includes:|
            Replicase polyprotein 1a (pp1a) (ORF1A)] [Contains:
            Leader protein; p65 homolog; NSP1 (EC 3.4.22.-)
            (Papain-like proteinase) (PL-PRO); 3C-like proteinase (EC
            3.4.22.-) (3CL-PRO) (3
          Length = 7073

 Score = 28.9 bits (63), Expect = 8.1
 Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
 Frame = +2

Query: 290  VRVERGSPLCPACEKFTNEALSYLGQKQSQDKMMEVLHEACSQ--TFSLEKKCVELVDSY 463
            +RVE  S L   C +  N+ L      ++ +KM+ +L    S      + + C E++D+ 
Sbjct: 3856 LRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNR 3915

Query: 464  ATL 472
            ATL
Sbjct: 3916 ATL 3918

>PASK_HUMAN (Q96RG2) PAS domain-containing serine/threonine-protein kinase (EC|
           2.7.11.1) (PAS-kinase) (PASKIN) (hPASK)
          Length = 1323

 Score = 28.9 bits (63), Expect = 8.1
 Identities = 16/44 (36%), Positives = 22/44 (50%)
 Frame = -1

Query: 485 SWQIRELHRSPPTQHTSSPTRMSENKLHEGPPSFYLVIASDQGS 354
           SW ++EL  S  T  TSS    + ++L E P S  +    D GS
Sbjct: 740 SWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPDVGS 783

>POLLU_LOTJA (Q5H8A5) Putative ion channel POLLUX, chloroplast precursor|
          Length = 917

 Score = 28.9 bits (63), Expect = 8.1
 Identities = 12/28 (42%), Positives = 16/28 (57%)
 Frame = -1

Query: 455 PPTQHTSSPTRMSENKLHEGPPSFYLVI 372
           PP   +SSP    ++  H  PP FYL+I
Sbjct: 140 PPPVPSSSPVARPQHHNHRSPPIFYLLI 167


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,278,952
Number of Sequences: 219361
Number of extensions: 1357162
Number of successful extensions: 4069
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 3793
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4068
length of database: 80,573,946
effective HSP length: 104
effective length of database: 57,760,402
effective search space used: 3581144924
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)