ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | basd2l01 |
|---|---|
| Clone Library Name | barley_pub |
>KC1D_ARATH (P42158) Casein kinase I isoform delta-like (EC 2.7.11.1)| (CKI-delta) Length = 450 Score = 320 bits (820), Expect = 2e-87 Identities = 150/168 (89%), Positives = 165/168 (98%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 MEPRVGNK+RLGRK+GSGSFGEIYLGTN+ TNEE+AIKLENVKTKHPQLLYESKLYR+LQ Sbjct: 1 MEPRVGNKFRLGRKIGSGSFGEIYLGTNIHTNEELAIKLENVKTKHPQLLYESKLYRILQ 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GGTG+ NVKWFGVEGDYNVLVMD+LGPSLEDLF+FC+RKLSLK+VLMLADQMINRVEF H Sbjct: 61 GGTGVPNVKWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKSVLMLADQMINRVEFFH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 SKSFLHRD+KPDNFLMGLG+RANQVY+IDFGLAKKYRD++THQHIPYR Sbjct: 121 SKSFLHRDLKPDNFLMGLGRRANQVYIIDFGLAKKYRDSTTHQHIPYR 168
>KC1E_MOUSE (Q9JMK2) Casein kinase I isoform epsilon (EC 2.7.11.1)| (CKI-epsilon) (CKIe) Length = 416 Score = 277 bits (709), Expect = 2e-74 Identities = 128/168 (76%), Positives = 151/168 (89%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 ME RVGNKYRLGRK+GSGSFG+IYLG N+ + EEVAIKLE VKTKHPQL ESK Y+++Q Sbjct: 1 MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG GI ++KW G EGDYNV+VM++LGPSLEDLF+FC+RK SLKTVL+LADQMI+R+E+IH Sbjct: 61 GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 SK+F+HRD+KPDNFLMGLGK+ N VY+IDFGLAKKYRD THQHIPYR Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYR 168
>KC1E_HUMAN (P49674) Casein kinase I isoform epsilon (EC 2.7.11.1)| (CKI-epsilon) (CKIe) Length = 416 Score = 277 bits (709), Expect = 2e-74 Identities = 128/168 (76%), Positives = 151/168 (89%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 ME RVGNKYRLGRK+GSGSFG+IYLG N+ + EEVAIKLE VKTKHPQL ESK Y+++Q Sbjct: 1 MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG GI ++KW G EGDYNV+VM++LGPSLEDLF+FC+RK SLKTVL+LADQMI+R+E+IH Sbjct: 61 GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 SK+F+HRD+KPDNFLMGLGK+ N VY+IDFGLAKKYRD THQHIPYR Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYR 168
>KC1_TOXGO (Q6QNM1) Casein kinase I (EC 2.7.11.1)| Length = 324 Score = 276 bits (706), Expect = 4e-74 Identities = 127/168 (75%), Positives = 151/168 (89%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 ME RVG KYRLGRK+GSGSFG+IY+G N+ T +EVAIKLE++K+KHPQLLYESKLY++L Sbjct: 1 MEVRVGGKYRLGRKIGSGSFGDIYIGANILTGDEVAIKLESIKSKHPQLLYESKLYKLLA 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG GI V W+G+EGDYNV+V+D+LGPSLEDLFS CNRKLSLKTVLMLADQM+NR+EF+H Sbjct: 61 GGIGIPMVHWYGIEGDYNVMVIDLLGPSLEDLFSICNRKLSLKTVLMLADQMLNRIEFVH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 SK+F+HRDIKPDNFL+G GK+ + VY+IDFGLAKKYRD T QHIPYR Sbjct: 121 SKNFIHRDIKPDNFLIGRGKKMSVVYIIDFGLAKKYRDPKTQQHIPYR 168
>KC1D_RAT (Q06486) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| Length = 415 Score = 275 bits (703), Expect = 8e-74 Identities = 126/168 (75%), Positives = 151/168 (89%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 ME RVGN+YRLGRK+GSGSFG+IYLGT++ EEVAIKLE VKTKHPQL ESK+Y+++Q Sbjct: 1 MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG GI ++W G EGDYNV+VM++LGPSLEDLF+FC+RK SLKTVL+LADQMI+R+E+IH Sbjct: 61 GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 SK+F+HRD+KPDNFLMGLGK+ N VY+IDFGLAKKYRD THQHIPYR Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYR 168
>KC1D_MOUSE (Q9DC28) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) Length = 415 Score = 275 bits (703), Expect = 8e-74 Identities = 126/168 (75%), Positives = 151/168 (89%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 ME RVGN+YRLGRK+GSGSFG+IYLGT++ EEVAIKLE VKTKHPQL ESK+Y+++Q Sbjct: 1 MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG GI ++W G EGDYNV+VM++LGPSLEDLF+FC+RK SLKTVL+LADQMI+R+E+IH Sbjct: 61 GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 SK+F+HRD+KPDNFLMGLGK+ N VY+IDFGLAKKYRD THQHIPYR Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYR 168
>KC1D_HUMAN (P48730) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) Length = 415 Score = 275 bits (703), Expect = 8e-74 Identities = 126/168 (75%), Positives = 151/168 (89%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 ME RVGN+YRLGRK+GSGSFG+IYLGT++ EEVAIKLE VKTKHPQL ESK+Y+++Q Sbjct: 1 MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG GI ++W G EGDYNV+VM++LGPSLEDLF+FC+RK SLKTVL+LADQMI+R+E+IH Sbjct: 61 GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 SK+F+HRD+KPDNFLMGLGK+ N VY+IDFGLAKKYRD THQHIPYR Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYR 168
>HHP1_SCHPO (P40235) Casein kinase I homolog hhp1 (EC 2.7.11.1)| Length = 365 Score = 273 bits (698), Expect = 3e-73 Identities = 127/168 (75%), Positives = 149/168 (88%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 ++ R+GNKYR+GRK+GSGSFG+IYLGTNV + EEVAIKLE+ + KHPQL YE ++YR+L Sbjct: 3 LDLRIGNKYRIGRKIGSGSFGDIYLGTNVVSGEEVAIKLESTRAKHPQLEYEYRVYRILS 62 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG GI V+WFGVE DYN +VMD+LGPSLEDLF+FCNRK SLKTVL+LADQ+I+R+EFIH Sbjct: 63 GGVGIPFVRWFGVECDYNAMVMDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEFIH 122 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 SKSFLHRDIKPDNFLMG+GKR NQV +IDFGLAKKYRD TH HIPYR Sbjct: 123 SKSFLHRDIKPDNFLMGIGKRGNQVNIIDFGLAKKYRDHKTHLHIPYR 170
>KC1_EIMTE (Q6QNL9) Casein kinase I (EC 2.7.11.1)| Length = 335 Score = 267 bits (682), Expect = 2e-71 Identities = 120/168 (71%), Positives = 149/168 (88%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 M+ RVG KYRLGRK+GSGSFG+IYLGTN+ T +EVAIKLE+V+++HPQL+YESKLY++L Sbjct: 1 MDVRVGGKYRLGRKIGSGSFGDIYLGTNISTGDEVAIKLESVRSRHPQLIYESKLYKILT 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG GI + W+G+EGDYNV+++++LGPSLEDLFS CNRKLSLKTVLMLADQM+NR+EF+H Sbjct: 61 GGIGIPTLYWYGIEGDYNVMIIELLGPSLEDLFSICNRKLSLKTVLMLADQMLNRIEFVH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 S+ F+HRDIKPDNFL+G GK+ + V+ IDFGLAKKYRD T HIPYR Sbjct: 121 SRHFIHRDIKPDNFLIGRGKKMSIVFAIDFGLAKKYRDPRTQSHIPYR 168
>KIN20_CAEEL (Q20471) Casein kinase I isoform delta (EC 2.7.11.1) (Protein| kinase 20) Length = 497 Score = 265 bits (677), Expect = 9e-71 Identities = 135/208 (64%), Positives = 162/208 (77%), Gaps = 2/208 (0%) Frame = +1 Query: 19 AQTLATNLRNSSLA--QVPP*LDALNLGGGSVACVRARPPMEPRVGNKYRLGRKLGSGSF 192 A TL L + LA Q+PP L V + ME RVGN++RLGRK+GSGSF Sbjct: 152 ALTLDPTLLSHFLATQQIPPVPQPL---------VHKKAEMELRVGNRFRLGRKIGSGSF 202 Query: 193 GEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVL 372 G+IYLG N+QTNEEVA+KLE VK+KHPQL ES+LYR++ GG GI ++W G EGDYNV+ Sbjct: 203 GDIYLGQNIQTNEEVAVKLECVKSKHPQLHIESRLYRIMLGGIGIPEIRWCGQEGDYNVM 262 Query: 373 VMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGK 552 VM++LGPSLEDLF+FC RK SLKTVL+LADQM++RVEFIH + ++HRDIKPDNFLMGLGK Sbjct: 263 VMELLGPSLEDLFNFCQRKFSLKTVLLLADQMLSRVEFIHCRDYIHRDIKPDNFLMGLGK 322 Query: 553 RANQVYMIDFGLAKKYRDTSTHQHIPYR 636 R N VY+IDFGLAK+YRD S HQHI YR Sbjct: 323 RGNLVYIIDFGLAKRYRD-SKHQHIAYR 349
>DCO_DROME (O76324) Discs overgrown protein kinase (EC 2.7.11.1) (Protein| double-time) Length = 440 Score = 260 bits (664), Expect = 3e-69 Identities = 120/168 (71%), Positives = 146/168 (86%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 ME RVGNKYRLGRK+GSGSFG+IYLGT + T EEVAIKLE ++TKHPQL ESK Y+ +Q Sbjct: 1 MELRVGNKYRLGRKIGSGSFGDIYLGTTINTGEEVAIKLECIRTKHPQLHIESKFYKTMQ 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG GI + W G EGDYNV+VM++LGPSLEDLF+FC+R+ SLKTVL+LADQMI+R+++IH Sbjct: 61 GGIGIPRIIWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRIDYIH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 S+ F+HRDIKPDNFLMGLGK+ N VY+IDFGLAKK+RD + +HIPYR Sbjct: 121 SRDFIHRDIKPDNFLMGLGKKGNLVYIIDFGLAKKFRDARSLKHIPYR 168
>KC1A_SHEEP (P67829) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 256 bits (655), Expect = 3e-68 Identities = 113/164 (68%), Positives = 145/164 (88%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG KY+L RK+GSGSFG+IYL N+ EEVA+KLE+ K +HPQLLYESKLY++LQGG G Sbjct: 13 VGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVG 72 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +++W+G E DYNVLVMD+LGPSLEDLF+FC+R+ ++KTVLMLADQMI+R+E++H+K+F Sbjct: 73 IPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 132 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 +HRDIKPDNFLMG+G+ N++++IDFGLAKKYRD T QHIPYR Sbjct: 133 IHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYR 176
>KC1A_RABIT (P67828) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 256 bits (655), Expect = 3e-68 Identities = 113/164 (68%), Positives = 145/164 (88%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG KY+L RK+GSGSFG+IYL N+ EEVA+KLE+ K +HPQLLYESKLY++LQGG G Sbjct: 13 VGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVG 72 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +++W+G E DYNVLVMD+LGPSLEDLF+FC+R+ ++KTVLMLADQMI+R+E++H+K+F Sbjct: 73 IPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 132 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 +HRDIKPDNFLMG+G+ N++++IDFGLAKKYRD T QHIPYR Sbjct: 133 IHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYR 176
>KC1A_BOVIN (P67827) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 256 bits (655), Expect = 3e-68 Identities = 113/164 (68%), Positives = 145/164 (88%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG KY+L RK+GSGSFG+IYL N+ EEVA+KLE+ K +HPQLLYESKLY++LQGG G Sbjct: 13 VGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVG 72 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +++W+G E DYNVLVMD+LGPSLEDLF+FC+R+ ++KTVLMLADQMI+R+E++H+K+F Sbjct: 73 IPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 132 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 +HRDIKPDNFLMG+G+ N++++IDFGLAKKYRD T QHIPYR Sbjct: 133 IHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYR 176
>KC1A_XENLA (P67963) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 256 bits (655), Expect = 3e-68 Identities = 113/164 (68%), Positives = 145/164 (88%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG KY+L RK+GSGSFG+IYL N+ EEVA+KLE+ K +HPQLLYESKLY++LQGG G Sbjct: 13 VGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVG 72 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +++W+G E DYNVLVMD+LGPSLEDLF+FC+R+ ++KTVLMLADQMI+R+E++H+K+F Sbjct: 73 IPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 132 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 +HRDIKPDNFLMG+G+ N++++IDFGLAKKYRD T QHIPYR Sbjct: 133 IHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYR 176
>KC1A_MOUSE (Q8BK63) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 256 bits (655), Expect = 3e-68 Identities = 113/164 (68%), Positives = 145/164 (88%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG KY+L RK+GSGSFG+IYL N+ EEVA+KLE+ K +HPQLLYESKLY++LQGG G Sbjct: 13 VGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVG 72 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +++W+G E DYNVLVMD+LGPSLEDLF+FC+R+ ++KTVLMLADQMI+R+E++H+K+F Sbjct: 73 IPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 132 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 +HRDIKPDNFLMG+G+ N++++IDFGLAKKYRD T QHIPYR Sbjct: 133 IHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYR 176
>KC1A_HUMAN (P48729) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 256 bits (655), Expect = 3e-68 Identities = 113/164 (68%), Positives = 145/164 (88%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG KY+L RK+GSGSFG+IYL N+ EEVA+KLE+ K +HPQLLYESKLY++LQGG G Sbjct: 13 VGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVG 72 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +++W+G E DYNVLVMD+LGPSLEDLF+FC+R+ ++KTVLMLADQMI+R+E++H+K+F Sbjct: 73 IPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 132 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 +HRDIKPDNFLMG+G+ N++++IDFGLAKKYRD T QHIPYR Sbjct: 133 IHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYR 176
>KC1A_CHICK (P67962) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 256 bits (655), Expect = 3e-68 Identities = 113/164 (68%), Positives = 145/164 (88%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG KY+L RK+GSGSFG+IYL N+ EEVA+KLE+ K +HPQLLYESKLY++LQGG G Sbjct: 13 VGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVG 72 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +++W+G E DYNVLVMD+LGPSLEDLF+FC+R+ ++KTVLMLADQMI+R+E++H+K+F Sbjct: 73 IPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 132 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 +HRDIKPDNFLMG+G+ N++++IDFGLAKKYRD T QHIPYR Sbjct: 133 IHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYR 176
>KC1A_RAT (P97633) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 254 bits (648), Expect = 2e-67 Identities = 112/164 (68%), Positives = 144/164 (87%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG KY+L RK+GSGSFG+IYL N+ EEVA+KLE+ K +HPQLLYESKLY++LQGG G Sbjct: 13 VGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVG 72 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +++W+G DYNVLVMD+LGPSLEDLF+FC+R+ ++KTVLMLADQMI+R+E++H+K+F Sbjct: 73 IPHIRWYGQGKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 132 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 +HRDIKPDNFLMG+G+ N++++IDFGLAKKYRD T QHIPYR Sbjct: 133 IHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYR 176
>KC1_PLAYO (Q7RBX5) Casein kinase I (EC 2.7.11.1)| Length = 323 Score = 251 bits (640), Expect = 2e-66 Identities = 110/168 (65%), Positives = 144/168 (85%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 ME RV NKY LG+KLGSGSFG+IY+ ++ T EE A+KLE+ ++KHPQLLYESKLY++L Sbjct: 1 MEIRVANKYALGKKLGSGSFGDIYVAKDIVTMEEFAVKLESTRSKHPQLLYESKLYKILG 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG G+ V W+G+EGD+ ++V+D+LGPSLEDLF+ CNRK SLKTVLM ADQM+NR+E++H Sbjct: 61 GGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVLMTADQMLNRIEYVH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 SK+F+HRDIKPDNFL+G GK+ +++IDFGLAKKYRD+ +H HIPY+ Sbjct: 121 SKNFIHRDIKPDNFLIGRGKKVTLIHIIDFGLAKKYRDSRSHTHIPYK 168
>KC1_PLAF7 (Q8IHZ9) Casein kinase I (EC 2.7.11.1)| Length = 323 Score = 251 bits (640), Expect = 2e-66 Identities = 110/168 (65%), Positives = 144/168 (85%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 ME RV NKY LG+KLGSGSFG+IY+ ++ T EE A+KLE+ ++KHPQLLYESKLY++L Sbjct: 1 MEIRVANKYALGKKLGSGSFGDIYVAKDIVTMEEFAVKLESTRSKHPQLLYESKLYKILG 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG G+ V W+G+EGD+ ++V+D+LGPSLEDLF+ CNRK SLKTVLM ADQM+NR+E++H Sbjct: 61 GGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVLMTADQMLNRIEYVH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 SK+F+HRDIKPDNFL+G GK+ +++IDFGLAKKYRD+ +H HIPY+ Sbjct: 121 SKNFIHRDIKPDNFLIGRGKKVTLIHIIDFGLAKKYRDSRSHTHIPYK 168
>KC1AL_HUMAN (Q8N752) Casein kinase I isoform alpha-like (EC 2.7.11.1)| (CKI-alpha-like) (CK1) Length = 337 Score = 249 bits (636), Expect = 5e-66 Identities = 113/164 (68%), Positives = 140/164 (85%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG KY+L RK+GSGSFG++YLG EEVA+KLE+ K KHPQLLYESKLY +LQGG G Sbjct: 13 VGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLYTILQGGVG 72 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I ++ W+G E D NVLVMD+LGPSLEDLF+FC+R+ ++KTVLMLADQMI+R+E++H+K+F Sbjct: 73 IPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 132 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 LHRDIKPDNFLMG G+ N++++IDFGLAKKYRD T QHIPYR Sbjct: 133 LHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYR 176
>YKL1_CAEEL (P42168) Putative casein kinase I C03C10.1 in chromosome III (EC| 2.7.11.1) Length = 341 Score = 248 bits (632), Expect = 1e-65 Identities = 110/164 (67%), Positives = 142/164 (86%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 V KY+L RK+GSGSFG+IY+ NV EEVAIKLE+ + +HPQLLYESK+YR+LQGG G Sbjct: 12 VATKYKLIRKIGSGSFGDIYVSINVTNGEEVAIKLESNRARHPQLLYESKVYRILQGGVG 71 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +++W+G E +YNVLVMD+LGPSLEDLF+FC+R+ ++KTVLMLADQMI R+E++H K+F Sbjct: 72 IPHIRWYGTEREYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIGRIEYVHVKNF 131 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 +HRDIKPDNFLMG+G+ N++++IDFGLAKKYRD+ T HIPYR Sbjct: 132 IHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRTHIPYR 175
>HRR25_YEAST (P29295) Casein kinase I homolog HRR25 (EC 2.7.11.1)| Length = 494 Score = 244 bits (622), Expect = 2e-64 Identities = 108/168 (64%), Positives = 146/168 (86%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 M+ RVG K+R+GRK+GSGSFG+IY GTN+ + EEVAIKLE+++++HPQL YES++YR L Sbjct: 1 MDLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIKLESIRSRHPQLDYESRVYRYLS 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG GI ++WFG EG+YN +V+D+LGPSLEDLF++C+R+ S KTV+MLA QM R+++IH Sbjct: 61 GGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 +SF+HRDIKPDNFLMG+G+R + V++IDFGL+KKYRD +TH+HIPYR Sbjct: 121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYR 168
>KC1_PLAF4 (O15726) Casein kinase I (EC 2.7.11.1)| Length = 324 Score = 243 bits (620), Expect = 3e-64 Identities = 107/168 (63%), Positives = 141/168 (83%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 ME RV NKY LG+KLGSGSFG+IY+ ++ T EE A+KLE+ ++KHPQLLYESKLY++L Sbjct: 1 MEIRVANKYALGKKLGSGSFGDIYVAKDIVTMEEFAVKLESTRSKHPQLLYESKLYKILG 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 GG G+ V W+G+EGD+ ++V+D+LGPSLEDLF+ CNRK SLKTV M ADQM+NR+E++H Sbjct: 61 GGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVRMTADQMLNRIEYVH 120 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 SK+F+HRDIKPDNFL+G GK+ +++IDFGLAKKYRD+ +H PY+ Sbjct: 121 SKNFIHRDIKPDNFLIGRGKKVTLIHIIDFGLAKKYRDSRSHTSYPYK 168
>HHP2_SCHPO (P40236) Casein kinase I homolog hhp2 (EC 2.7.11.1)| Length = 400 Score = 234 bits (596), Expect = 2e-61 Identities = 108/165 (65%), Positives = 134/165 (81%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGT 321 ++GNKYR+GRK+GSGSFG+IYLG N E+VA+KLE +K +H QL YE ++Y +L+G Sbjct: 7 KIGNKYRIGRKIGSGSFGQIYLGLNTVNGEQVAVKLEPLKARHHQLEYEFRVYNILKGNI 66 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 GI ++WFGV YN +VMD+LGPSLEDLF +C RK +LKTVL+LADQ+I+R+E++HSKS Sbjct: 67 GIPTIRWFGVTNSYNAMVMDLLGPSLEDLFCYCGRKFTLKTVLLLADQLISRIEYVHSKS 126 Query: 502 FLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 FLHRDIKPDNFLM K +N V MIDFGLAKKYRD TH HIPYR Sbjct: 127 FLHRDIKPDNFLM--KKHSNVVTMIDFGLAKKYRDFKTHVHIPYR 169
>KC1A_DROME (P54367) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (DmCK1) Length = 337 Score = 229 bits (583), Expect = 7e-60 Identities = 104/164 (63%), Positives = 133/164 (81%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG KYR+ RK+GSGSFG+IYLG ++Q+ EEVAIK+E+ +HPQLLYE+KLYR+L GG G Sbjct: 16 VGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGVG 75 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 ++ G E ++N LVMD+LGPSLEDLF+FC R ++KTVLML DQMI R+E+IH K F Sbjct: 76 FPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCF 135 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 +HRDIKPDNFLMG+G+ N++++IDFGLAKK+RD T HI YR Sbjct: 136 IHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKFRDPHTRHHIVYR 179
>KC1B_BOVIN (P35507) Casein kinase I isoform beta (EC 2.7.11.1) (CKI-beta)| Length = 336 Score = 228 bits (582), Expect = 9e-60 Identities = 101/172 (58%), Positives = 140/172 (81%) Frame = +1 Query: 121 ARPPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLY 300 +RP + VG +Y+L R++G GSFG +YL ++ +E+VA+KLE+ T+ P+LL+E +LY Sbjct: 5 SRPKTDVLVGGRYKLVREIGFGSFGHVYLAIDLTNHEQVAVKLESENTRQPRLLHEKELY 64 Query: 301 RVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRV 480 LQGG GI ++W+G E DYNVLVMD+LGPSLEDLF+FC+R+ S+KTVLMLADQMI+R+ Sbjct: 65 NFLQGGVGIPQIRWYGQETDYNVLVMDLLGPSLEDLFNFCSRRFSMKTVLMLADQMISRI 124 Query: 481 EFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 E++HS++ +HRDIKPDNFLMG G + +++++DFGLAKKYRD T QHIP+R Sbjct: 125 EYVHSRNLIHRDIKPDNFLMGTGPQWKKLFLVDFGLAKKYRDNRTGQHIPHR 176
>KC1A_PIG (O19175) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) (Fragment) Length = 125 Score = 201 bits (511), Expect = 2e-51 Identities = 87/124 (70%), Positives = 115/124 (92%) Frame = +1 Query: 229 EEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDL 408 EEVA+KLE+ K +HPQLLYESKLY++LQGG GI +++W+G E DYNVLVMD+LGPSLEDL Sbjct: 2 EEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDL 61 Query: 409 FSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGL 588 F+FC+R+ ++KTVLMLADQMI+R+E++H+K+F+HRDIKPDNFLMG+G+ N++++IDFGL Sbjct: 62 FNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGL 121 Query: 589 AKKY 600 AKKY Sbjct: 122 AKKY 125
>CKI2_SCHPO (P40234) Casein kinase I homolog 2 (EC 2.7.11.1)| Length = 435 Score = 189 bits (481), Expect = 5e-48 Identities = 93/165 (56%), Positives = 122/165 (73%), Gaps = 2/165 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG YR+GRK+G GSFG I+ G N+ N+ +AIK E K++ PQL E + Y++L G G Sbjct: 8 VGVHYRVGRKIGEGSFGVIFDGMNLLNNQLIAIKFEPKKSEAPQLRDEYRTYKLLVGNAG 67 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I NV +FG EG +N+LV+D+LGPSLEDLF +C R+ S+KTV M A QM++RV+ IH K+ Sbjct: 68 IPNVYYFGQEGLHNILVIDLLGPSLEDLFEWCGRRFSVKTVAMTAKQMLSRVQTIHEKNL 127 Query: 505 LHRDIKPDNFLMG--LGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 ++RDIKPDNFL+G + AN VYM+DFG+AK YRD T QHIPY Sbjct: 128 VYRDIKPDNFLIGRPSSRNANMVYMVDFGMAKYYRDPKTKQHIPY 172
>CKI1_SCHPO (P40233) Casein kinase I homolog 1 (EC 2.7.11.1)| Length = 446 Score = 188 bits (477), Expect = 1e-47 Identities = 93/166 (56%), Positives = 121/166 (72%), Gaps = 2/166 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG Y++GR++G GSFG I+ GTN+ N++VAIK E ++ PQL E + Y++L G TG Sbjct: 8 VGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTG 67 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I NV +FG EG +N+LV+D+LGPSLEDL C RK S+KTV M A QM+ RV+ IH KS Sbjct: 68 IPNVYYFGQEGLHNILVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSL 127 Query: 505 LHRDIKPDNFLMGL--GKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 ++RDIKPDNFL+G K AN +Y++DFG+ K YRD T QHIPYR Sbjct: 128 VYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYR 173
>KC1G3_RAT (Q62763) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) Length = 448 Score = 187 bits (475), Expect = 2e-47 Identities = 92/166 (55%), Positives = 127/166 (76%), Gaps = 2/166 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG +R+G+K+G G+FGE+ LG N+ TNE VAIKLE +K++ PQL E + Y+ L G G Sbjct: 39 VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDG 98 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I V +FG G YN +V+++LGPSLEDLF C+R SLKTVLM+A Q+I+R+E++HSK+ Sbjct: 99 IPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 158 Query: 505 LHRDIKPDNFLMGL-GKRANQV-YMIDFGLAKKYRDTSTHQHIPYR 636 ++RD+KP+NFL+G G +A QV ++IDFGLAK+Y D T +HIPYR Sbjct: 159 IYRDVKPENFLIGRPGNKAQQVIHIIDFGLAKEYIDPETKKHIPYR 204
>KC1G3_HUMAN (Q9Y6M4) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) Length = 447 Score = 186 bits (471), Expect = 7e-47 Identities = 91/166 (54%), Positives = 126/166 (75%), Gaps = 2/166 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG +R+G+K+G G+FGE+ LG N+ TNE VAIKLE +K++ PQL E + Y+ L G G Sbjct: 39 VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDG 98 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I V +FG G YN +V+++LGPSLEDLF C+R SLKTVLM+A Q+I+R+E++HSK+ Sbjct: 99 IPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 158 Query: 505 LHRDIKPDNFLMGL-GKRANQV-YMIDFGLAKKYRDTSTHQHIPYR 636 ++RD+KP+NFL+G G + QV ++IDFGLAK+Y D T +HIPYR Sbjct: 159 IYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYR 204
>KC1G3_BOVIN (P35509) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) (Fragment) Length = 276 Score = 186 bits (471), Expect = 7e-47 Identities = 91/166 (54%), Positives = 126/166 (75%), Gaps = 2/166 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG +R+G+K+G G+FGE+ LG N+ TNE VAIKLE +K++ PQL E + Y+ L G G Sbjct: 25 VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDG 84 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I V +FG G YN +V+++LGPSLEDLF C+R SLKTVLM+A Q+I+R+E++HSK+ Sbjct: 85 IPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 144 Query: 505 LHRDIKPDNFLMGL-GKRANQV-YMIDFGLAKKYRDTSTHQHIPYR 636 ++RD+KP+NFL+G G + QV ++IDFGLAK+Y D T +HIPYR Sbjct: 145 IYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYR 190
>KC1G2_RAT (Q62762) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 184 bits (467), Expect = 2e-46 Identities = 87/166 (52%), Positives = 124/166 (74%), Gaps = 2/166 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG +R+G+K+G G+FGE+ LG N+ TNE VAIKLE +K++ PQL E + Y+ L G Sbjct: 42 VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSTTEG 101 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 + V +FG G YN +V+++LGPSLEDLF C+R +LKTVLM+A Q+I R+E++H+KS Sbjct: 102 VPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSL 161 Query: 505 LHRDIKPDNFLMGL--GKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 ++RD+KP+NFL+G KR + +++IDFGLAK+Y D T +HIPYR Sbjct: 162 IYRDVKPENFLVGRPGSKRQHSIHIIDFGLAKEYIDPETKKHIPYR 207
>KC1G2_MOUSE (Q8BVP5) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 184 bits (467), Expect = 2e-46 Identities = 87/166 (52%), Positives = 124/166 (74%), Gaps = 2/166 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG +R+G+K+G G+FGE+ LG N+ TNE VAIKLE +K++ PQL E + Y+ L G Sbjct: 42 VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSTTEG 101 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 + V +FG G YN +V+++LGPSLEDLF C+R +LKTVLM+A Q+I R+E++H+KS Sbjct: 102 VPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSL 161 Query: 505 LHRDIKPDNFLMGL--GKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 ++RD+KP+NFL+G KR + +++IDFGLAK+Y D T +HIPYR Sbjct: 162 IYRDVKPENFLVGRPGSKRQHSIHIIDFGLAKEYIDPETKKHIPYR 207
>KC1G2_HUMAN (P78368) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 184 bits (466), Expect = 3e-46 Identities = 87/166 (52%), Positives = 124/166 (74%), Gaps = 2/166 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG +R+G+K+G G+FGE+ LG N+ TNE VAIKLE +K++ PQL E + Y+ L G Sbjct: 42 VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEG 101 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 + V +FG G YN +V+++LGPSLEDLF C+R +LKTVLM+A Q+I R+E++H+KS Sbjct: 102 VPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSL 161 Query: 505 LHRDIKPDNFLMGL--GKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 ++RD+KP+NFL+G KR + +++IDFGLAK+Y D T +HIPYR Sbjct: 162 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYR 207
>CKI3_SCHPO (O74135) Casein kinase I homolog 3 (EC 2.7.11.1)| Length = 439 Score = 182 bits (462), Expect = 7e-46 Identities = 86/165 (52%), Positives = 119/165 (72%), Gaps = 2/165 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG YR+G+K+G GSFG ++ G N+ N+ +A+K E+ K++ PQL E Y++L G G Sbjct: 11 VGVHYRVGKKIGEGSFGMLFQGVNLINNQPIALKFESRKSEVPQLRDEYLTYKLLMGLPG 70 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +V ++G EG YN+LVMD+LGPSLEDLF +C R+ S KTV M+A QMI R++ +H + F Sbjct: 71 IPSVYYYGQEGMYNLLVMDLLGPSLEDLFDYCGRRFSPKTVAMIAKQMITRIQSVHERHF 130 Query: 505 LHRDIKPDNFLMGL--GKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 ++RDIKPDNFL+G K N +Y +DFG+AK+YRD TH H PY Sbjct: 131 IYRDIKPDNFLIGFPGSKTENVIYAVDFGMAKQYRDPKTHVHRPY 175
>KC1G1_RAT (Q62761) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 390 Score = 181 bits (458), Expect = 2e-45 Identities = 86/167 (51%), Positives = 126/167 (75%), Gaps = 3/167 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVL-QGGT 321 VG +R+G+K+G G+FGE+ LG N+ TNE VAIKLE +K++ PQL E + Y+ L G Sbjct: 40 VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGE 99 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 G+ V +FG G YN +V+++LGPSLEDLF C+R +LKTVLM+A Q+++R+E++HSK+ Sbjct: 100 GLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKN 159 Query: 502 FLHRDIKPDNFLMGL--GKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 ++RD+KP+NFL+G K+ + +++IDFGLAK+Y D T +HIPYR Sbjct: 160 LIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYR 206
>KC1G1_MOUSE (Q8BTH8) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 459 Score = 181 bits (458), Expect = 2e-45 Identities = 86/167 (51%), Positives = 126/167 (75%), Gaps = 3/167 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVL-QGGT 321 VG +R+G+K+G G+FGE+ LG N+ TNE VAIKLE +K++ PQL E + Y+ L G Sbjct: 40 VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGE 99 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 G+ V +FG G YN +V+++LGPSLEDLF C+R +LKTVLM+A Q+++R+E++HSK+ Sbjct: 100 GLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKN 159 Query: 502 FLHRDIKPDNFLMGL--GKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 ++RD+KP+NFL+G K+ + +++IDFGLAK+Y D T +HIPYR Sbjct: 160 LIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYVDPETKKHIPYR 206
>KC1G1_HUMAN (Q9HCP0) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 422 Score = 181 bits (458), Expect = 2e-45 Identities = 86/167 (51%), Positives = 126/167 (75%), Gaps = 3/167 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVL-QGGT 321 VG +R+G+K+G G+FGE+ LG N+ TNE VAIKLE +K++ PQL E + Y+ L G Sbjct: 40 VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGE 99 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 G+ V +FG G YN +V+++LGPSLEDLF C+R +LKTVLM+A Q+++R+E++HSK+ Sbjct: 100 GLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKN 159 Query: 502 FLHRDIKPDNFLMGL--GKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 ++RD+KP+NFL+G K+ + +++IDFGLAK+Y D T +HIPYR Sbjct: 160 LIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYR 206
>RAG8_KLULA (P40230) Casein kinase I homolog RAG8 (EC 2.7.11.1)| Length = 536 Score = 176 bits (446), Expect = 5e-44 Identities = 87/166 (52%), Positives = 116/166 (69%), Gaps = 2/166 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG Y++G+K+G GSFG ++ G N+ N VAIK E KT PQL E + Y++L G G Sbjct: 73 VGLHYKIGKKIGEGSFGVLFEGVNMINNVPVAIKFEPRKTDAPQLKDEYRTYKILSGSEG 132 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +FG EG +N+LV+D+LGPSLEDLF +C R+ S+KTV+ +A QMI +E +H Sbjct: 133 IPQAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSIKTVVHVAIQMITLIEELHDHDL 192 Query: 505 LHRDIKPDNFLMGLGKR--ANQVYMIDFGLAKKYRDTSTHQHIPYR 636 ++RDIKPDNFL+G + AN V++IDFG+AK YRD T QHIPYR Sbjct: 193 IYRDIKPDNFLIGRPNQPDANMVHLIDFGMAKLYRDPKTKQHIPYR 238
>KC11_YEAST (P23291) Casein kinase I homolog 1 (EC 2.7.11.1)| Length = 538 Score = 176 bits (445), Expect = 7e-44 Identities = 87/166 (52%), Positives = 118/166 (71%), Gaps = 2/166 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG Y++G+K+G GSFG ++ GTN+ VAIK E KT+ PQL E K Y++L G Sbjct: 65 VGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPN 124 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +FG EG +N+LV+D+LGPSLEDLF +C RK S+KTV+ +A QMI +E +H+ Sbjct: 125 IPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDL 184 Query: 505 LHRDIKPDNFLMGLGKR--ANQVYMIDFGLAKKYRDTSTHQHIPYR 636 ++RDIKPDNFL+G + AN +++IDFG+AK+YRD T QHIPYR Sbjct: 185 IYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYR 230
>KC12_YEAST (P23292) Casein kinase I homolog 2 (EC 2.7.11.1)| Length = 546 Score = 176 bits (445), Expect = 7e-44 Identities = 87/166 (52%), Positives = 120/166 (72%), Gaps = 2/166 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 VG Y++G+K+G GSFG ++ GTN+ VAIK E KT+ PQL E + Y++L G G Sbjct: 72 VGLHYKIGKKIGEGSFGVLFEGTNMINGLPVAIKFEPRKTEAPQLKDEYRTYKILAGTPG 131 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I +FG EG +N+LV+D+LGPSLEDLF +C R+ S+KTV+ +A QMI +E +H+ Sbjct: 132 IPQEYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAVQMITLIEDLHAHDL 191 Query: 505 LHRDIKPDNFLMGLGKR--ANQVYMIDFGLAKKYRDTSTHQHIPYR 636 ++RDIKPDNFL+G + AN+V++IDFG+AK+YRD T QHIPYR Sbjct: 192 IYRDIKPDNFLIGRPGQPDANKVHLIDFGMAKQYRDPKTKQHIPYR 237
>KC13_YEAST (P39962) Casein kinase I homolog 3 (EC 2.7.11.1)| Length = 524 Score = 162 bits (410), Expect = 8e-40 Identities = 89/199 (44%), Positives = 115/199 (57%), Gaps = 35/199 (17%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNV-----------------QTNEEVAIKLENVKTKHP 273 VG Y +G K+G GSFG I+ G N+ NE VAIK E + P Sbjct: 10 VGIHYAVGPKIGEGSFGVIFEGENILHSCQAQTGSKRDSSIIMANEPVAIKFEPRHSDAP 69 Query: 274 QLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLM 453 QL E + YR+L G GI + +FG EG +N+L++D+LGPSLEDLF +C RK S+KT M Sbjct: 70 QLRDEFRAYRILNGCVGIPHAYYFGQEGMHNILIIDLLGPSLEDLFEWCGRKFSVKTTCM 129 Query: 454 LADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKR------------------ANQVYMID 579 +A QMI+RV IH ++RDIKPDNFL+ +R N +YM+D Sbjct: 130 VAKQMIDRVRAIHDHDLIYRDIKPDNFLISQYQRISPEGKVIKSCASSSNNDPNLIYMVD 189 Query: 580 FGLAKKYRDTSTHQHIPYR 636 FG+AK+YRD T QHIPYR Sbjct: 190 FGMAKQYRDPRTKQHIPYR 208
>TTBK1_HUMAN (Q5TCY1) Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau| kinase) Length = 1321 Score = 103 bits (258), Expect = 3e-22 Identities = 65/175 (37%), Positives = 96/175 (54%), Gaps = 2/175 (1%) Frame = +1 Query: 94 GGGSVACVRARPPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHP 273 GGG A + P V +++++ +K+G G FGEIY ++ T E VA+K+E+ + Sbjct: 16 GGGEQADIL---PANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQ 72 Query: 274 QLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNR-KLSLKTVL 450 L E + + LQG + G +N +VM + G +L DL R +L T L Sbjct: 73 VLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTL 132 Query: 451 MLADQMINRVEFIHSKSFLHRDIKPDNFLMG-LGKRANQVYMIDFGLAKKYRDTS 612 L Q++ +E IHS FLHRDIKP NF MG L + YM+DFGLA++Y +T+ Sbjct: 133 RLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTT 187
>TTBK2_HUMAN (Q6IQ55) Tau-tubulin kinase 2 (EC 2.7.11.1)| Length = 1244 Score = 98.6 bits (244), Expect = 1e-20 Identities = 57/157 (36%), Positives = 88/157 (56%), Gaps = 2/157 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 V ++++ RK+G G FGEIY ++ T E VA+K+E+ + L E + + LQG Sbjct: 17 VKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDH 76 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNR-KLSLKTVLMLADQMINRVEFIHSKS 501 + G +N +VM + G +L DL +R ++ T L L Q++ +E IHS Sbjct: 77 VCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVG 136 Query: 502 FLHRDIKPDNFLMG-LGKRANQVYMIDFGLAKKYRDT 609 FLHRDIKP NF MG + YM+DFGLA+++ ++ Sbjct: 137 FLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNS 173
>TTBK2_MOUSE (Q3UVR3) Tau-tubulin kinase 2| Length = 1243 Score = 97.4 bits (241), Expect = 3e-20 Identities = 56/157 (35%), Positives = 88/157 (56%), Gaps = 2/157 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 V ++++ RK+G G FGEIY ++ T E VA+K+E+ + L E + + LQG Sbjct: 17 VKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDH 76 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNR-KLSLKTVLMLADQMINRVEFIHSKS 501 + G +N +VM + G +L DL +R ++ T L L Q++ +E IHS Sbjct: 77 VCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGKQILESIESIHSVG 136 Query: 502 FLHRDIKPDNFLMG-LGKRANQVYMIDFGLAKKYRDT 609 FLHRDIKP NF MG + +M+DFGLA+++ ++ Sbjct: 137 FLHRDIKPSNFAMGRFPSTCRKCFMLDFGLARQFTNS 173
>YKL2_CAEEL (P42169) Putative casein kinase I C03C10.2 in chromosome III (EC| 2.7.11.1) Length = 363 Score = 80.5 bits (197), Expect = 4e-15 Identities = 51/172 (29%), Positives = 99/172 (57%), Gaps = 10/172 (5%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLE-----NVKTKHPQLLYESKLYRVLQG 315 N++ + +G+G +G+I++ +V+ N+E A+K+E V TK +++ E ++ +QG Sbjct: 70 NRWSIEGVIGNGGYGQIFMVMDVKKNDERAMKIEPKLRAEVITK--RMIMEQQVLMKMQG 127 Query: 316 GTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNR----KLSLKTVLMLADQMINRVE 483 T I + G +N ++M +L ++ D F R +LS +TV +A Q +N ++ Sbjct: 128 KTHIPTMYASGFNDQFNFIIMQLLSMNVGD---FRKRSPLGRLSKETVGRIAYQTLNALK 184 Query: 484 FIHSKSFLHRDIKPDNFLMGL-GKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 IH ++HRD+KP N G+ + + +Y++DFGL ++++ T + IP+R Sbjct: 185 DIHDMGYVHRDVKPANICFGVHAQNRHILYLLDFGLVRRFK-TESGVCIPWR 235
>V212_FOWPV (Q9J523) Probable serine/threonine-protein kinase FPV212 (EC| 2.7.11.1) Length = 303 Score = 74.3 bits (181), Expect = 3e-13 Identities = 56/182 (30%), Positives = 90/182 (49%), Gaps = 19/182 (10%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLY-RVL 309 +E NK+ LG++LGSG FG +Y + + K+E ++ L E Y RV+ Sbjct: 17 LEDITKNKWILGKQLGSGGFGLVYQVSCKSKEIDCVAKIELKESGG--LFCEINFYNRVM 74 Query: 310 QGGT--------------GISNVKWFGV----EGDYNVLVMDVLGPSLEDLFSFCNRKLS 435 + T GI + FG+ +Y ++ LG LE++ S K + Sbjct: 75 KNKTSLDTWMKEQKIDYIGIPSFHGFGITIYKNVEYRFAIIQRLGRDLENILSE-KEKFN 133 Query: 436 LKTVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTST 615 + + LA ++++ ++FIHSK F H DIK N L GK ++VY++D+GLA KY Sbjct: 134 ITVIKKLAIKILDILKFIHSKEFSHGDIKAGNIL--FGKDDDKVYLVDYGLATKYSSNGK 191 Query: 616 HQ 621 H+ Sbjct: 192 HK 193
>KC1D_RABIT (P81123) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) (Fragment) Length = 81 Score = 73.9 bits (180), Expect = 4e-13 Identities = 33/40 (82%), Positives = 35/40 (87%) Frame = +1 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 I PDNFLMGLGK+ N VY+IDFGLAKKYRD THQHIPYR Sbjct: 2 IFPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYR 41
>VRK2_HUMAN (Q86Y07) Serine/threonine-protein kinase VRK2 (EC 2.7.11.1)| (Vaccinia-related kinase 2) Length = 508 Score = 73.2 bits (178), Expect = 6e-13 Identities = 56/181 (30%), Positives = 87/181 (48%), Gaps = 23/181 (12%) Frame = +1 Query: 148 GNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVK-TKHPQLLYESKLYR------- 303 GN++ LG+K+GSG FG IYL E+ A + V+ ++ L E K Y+ Sbjct: 26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 85 Query: 304 ---------------VLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSL 438 L G+G++ K Y +VM+ LG L+ + S N Sbjct: 86 IKKWIERKQLDYLGIPLFYGSGLTEFKG----RSYRFMVMERLGIDLQKI-SGQNGTFKK 140 Query: 439 KTVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTH 618 TVL L +M++ +E+IH ++H DIK N L+G K +QVY+ D+GL+ +Y H Sbjct: 141 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNH 199 Query: 619 Q 621 + Sbjct: 200 K 200
>VRK1_MOUSE (Q80X41) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK) Length = 440 Score = 72.8 bits (177), Expect = 8e-13 Identities = 52/179 (29%), Positives = 89/179 (49%), Gaps = 23/179 (12%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLG-TN----VQTNEEVAIKLENVKTKHPQLLYESKLYR----- 303 +++LG +G G FG IYL TN V ++ +K+E + + L E K Y+ Sbjct: 36 EWKLGLPIGQGGFGCIYLADTNSSKPVGSDAPCVVKVE--PSDNGPLFTELKFYQRAAKP 93 Query: 304 -VLQGGTGISNVKWFGVEG------------DYNVLVMDVLGPSLEDLFSFCNRKLSLKT 444 +Q +K+ GV Y ++MD G L+ ++ ++ S KT Sbjct: 94 EQIQKWIRTHKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 Query: 445 VLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQ 621 VL L+ ++++ +E+IH ++H DIK N L+ K +QVY++D+GLA +Y H+ Sbjct: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLS-HKNPDQVYLVDYGLAYRYCPDGVHK 211
>VRK1_HUMAN (Q99986) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) Length = 396 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/178 (28%), Positives = 86/178 (48%), Gaps = 22/178 (12%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQ----LLYESKLYR------ 303 ++++G +G G FG IYL ++ ++E V V P L E K Y+ Sbjct: 36 EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 Query: 304 VLQGGTGISNVKWFGVEG------------DYNVLVMDVLGPSLEDLFSFCNRKLSLKTV 447 +Q +K+ GV Y ++MD G L+ ++ ++ S KTV Sbjct: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 Query: 448 LMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQ 621 L L+ ++++ +E+IH ++H DIK N L+ K +QVY++D+GLA +Y H+ Sbjct: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCPEGVHK 211
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 72.0 bits (175), Expect = 1e-12 Identities = 51/154 (33%), Positives = 78/154 (50%), Gaps = 7/154 (4%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQ------LLYESKLYRVLQG 315 ++R+ R LGSG GE+YLG V +VAIK+ + H Q E++L ++ Sbjct: 12 RFRVLRPLGSGGMGEVYLGEQVSLGRKVAIKVLH-HDLHAQAGMAERFKREARLLSAVEH 70 Query: 316 GTGISNVKWFGVEGDYNVLVMD-VLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 + V FG GD+ LVM+ V G SL D+ + + L L Q+ + IH Sbjct: 71 PAVVRIVD-FGESGDHACLVMEFVEGESLYDVLT--PGPMPPGRALPLLQQLAEGLAAIH 127 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAK 594 K +HRD+KP+N + R Q ++DFG+A+ Sbjct: 128 DKGIIHRDLKPENVFISKSARGEQARLLDFGIAR 161
>YOO3_CAEEL (P34635) Putative serine/threonine-protein kinase ZK507.3 (EC| 2.7.11.1) Length = 374 Score = 70.5 bits (171), Expect = 4e-12 Identities = 34/88 (38%), Positives = 52/88 (59%), Gaps = 1/88 (1%) Frame = +1 Query: 343 FGVEGDYNVLVMDVLGPSLEDL-FSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRDI 519 FG + +VM ++GPSLE+L + + T+L Q + + H FLHRDI Sbjct: 100 FGQSPVWKWIVMTIVGPSLEELKMKYKPSDIPPSTILQCGLQTMKAIHDFHQIGFLHRDI 159 Query: 520 KPDNFLMGLGKRANQVYMIDFGLAKKYR 603 KP N+ +G G ++ +Y++DFGLA+KYR Sbjct: 160 KPANYCIGYGSKSETIYVLDFGLARKYR 187
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 70.5 bits (171), Expect = 4e-12 Identities = 47/155 (30%), Positives = 78/155 (50%), Gaps = 6/155 (3%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHP-----QLLYES-KLYRVLQGG 318 Y GR LG+GSFG + + TNE+VAIK+ K Q+LYE + + L Sbjct: 47 YIFGRTLGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLSHP 106 Query: 319 TGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSK 498 +S WF + + ++ G L D + + V ++ Q++ VE++HSK Sbjct: 107 NIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIV-QILGAVEYMHSK 165 Query: 499 SFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYR 603 + +HRD+KP+N L + + + DFG+AK+ + Sbjct: 166 NVVHRDLKPENVLYVDKSENSPLVIADFGIAKQLK 200
>YOO1_CAEEL (P34633) Putative serine/threonine-protein kinase ZK507.1 (EC| 2.7.11.1) Length = 331 Score = 70.5 bits (171), Expect = 4e-12 Identities = 34/88 (38%), Positives = 52/88 (59%), Gaps = 1/88 (1%) Frame = +1 Query: 343 FGVEGDYNVLVMDVLGPSLEDL-FSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRDI 519 FG + +VM ++GPSLE+L + + T+L Q + + H FLHRDI Sbjct: 58 FGQSPVWKWIVMTIVGPSLEELKMKYKPSDIPPSTILQCGLQTMKAIHDFHQIGFLHRDI 117 Query: 520 KPDNFLMGLGKRANQVYMIDFGLAKKYR 603 KP N+ +G G ++ +Y++DFGLA+KYR Sbjct: 118 KPANYCIGYGSKSETIYVLDFGLARKYR 145
>PAK1_CAEEL (Q17850) Serine/threonine-protein kinase pak-1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK1) (CePAK) Length = 572 Score = 69.7 bits (169), Expect = 7e-12 Identities = 51/172 (29%), Positives = 88/172 (51%), Gaps = 9/172 (5%) Frame = +1 Query: 145 VGN---KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT--KHPQLLYESKLYRVL 309 +GN KYR K+GSG+ G +Y + T EVAIK N+K K ++ E + R Sbjct: 288 IGNPDRKYRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMREN 347 Query: 310 QGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFI 489 + ++ + + V + V++ + G SL D+ + C + + + + +++ +EF+ Sbjct: 348 KHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGI--IAAVCREVLQALEFL 405 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFG----LAKKYRDTSTHQHIPY 633 HS+ +HRDIK DN L+G+ V + DFG L+ + R +T PY Sbjct: 406 HSRHVIHRDIKSDNILLGMD---GSVKLTDFGFCAQLSPEQRKRTTMVGTPY 454
>VRK1_BRARE (Q7ZUS1) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) Length = 425 Score = 69.3 bits (168), Expect = 9e-12 Identities = 50/172 (29%), Positives = 80/172 (46%), Gaps = 23/172 (13%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTN-----VQTNEEVAIKLENVKTKHPQLLYESKLYR----- 303 K++LG +G G FG +YL V + IK+E + + L E K Y Sbjct: 37 KWKLGSAVGQGGFGLLYLANEDSSGPVTADAPYVIKVE--PSDNGPLFSELKFYMRAAKP 94 Query: 304 -VLQGGTGISNVKWFGVEG------------DYNVLVMDVLGPSLEDLFSFCNRKLSLKT 444 ++ +++ GV Y +VMD G L+ LF +K S K Sbjct: 95 DLIGAWMKSKKMEYLGVPKYWGSGFHEKNGKRYRFMVMDRFGTDLQKLFEGNGKKFSRKL 154 Query: 445 VLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 VL L ++++ +E+IH ++H DIK N L+ NQV+++D+GLA +Y Sbjct: 155 VLQLGLRLLDILEYIHDHEYVHADIKASNLLLSY-TNPNQVFLVDYGLAYRY 205
>PIM1_BRARE (Q9YHZ5) Serine/threonine-protein kinase Pim-1 (EC 2.7.11.1)| Length = 310 Score = 68.9 bits (167), Expect = 1e-11 Identities = 53/171 (30%), Positives = 82/171 (47%), Gaps = 19/171 (11%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVK--TKHP----QLLYESKLYRV 306 +Y +G LGSG FG +Y G + ++VAIK + ++ +K P + E L + Sbjct: 29 QYTMGNLLGSGGFGSVYSGHRISDGQKVAIKQISRDRIQQWSKMPGEVNPVPNEIALLQS 88 Query: 307 LQGGTG--------ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVL--ML 456 L GG+G I + WF + G ++V + +DLF F + L L Sbjct: 89 LGGGSGSVPGHRGIIRMLDWFEIPGQEYLIVFE-KPQHCQDLFDFITERGRLDESLARRF 147 Query: 457 ADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 Q+I V+F HSK +HRDIK +N L + R + +IDFG +D+ Sbjct: 148 LKQVIEAVQFCHSKGIVHRDIKDENIL--VDTRTGDIKVIDFGSGATLKDS 196
>CDC7_HUMAN (O00311) Cell division cycle 7-related protein kinase (EC 2.7.11.1)| (CDC7-related kinase) (HsCdc7) (huCdc7) Length = 574 Score = 68.2 bits (165), Expect = 2e-11 Identities = 48/161 (29%), Positives = 79/161 (49%), Gaps = 4/161 (2%) Frame = +1 Query: 139 PRVGNKYRLGRKLGSGSFGEIYLGT---NVQTNEEVAIKLENVKTKHP-QLLYESKLYRV 306 P++ N +++ K+G G+F +YL T V E++A+K + T HP ++ E + V Sbjct: 52 PQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALK-HLIPTSHPIRIAAELQCLTV 110 Query: 307 LQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEF 486 G + VK+ + D+ V+ M L E N LS + V + ++ Sbjct: 111 AGGQDNVMGVKYCFRKNDHVVIAMPYL--EHESFLDILN-SLSFQEVREYMLNLFKALKR 167 Query: 487 IHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 IH +HRD+KP NFL +R + ++DFGLA+ DT Sbjct: 168 IHQFGIVHRDVKPSNFL--YNRRLKKYALVDFGLAQGTHDT 206
>VPK1_VACCV (P16913) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 67.8 bits (164), Expect = 3e-11 Identities = 48/179 (26%), Positives = 90/179 (50%), Gaps = 18/179 (10%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLY-RVLQGGT-- 321 N++ +G +G G FG IY TN + +K+E + L E Y RVL+ Sbjct: 14 NQWVVGPLIGKGGFGSIYT-TN---DNNYVVKIE--PKANGSLFTEQAFYTRVLKPSVIE 67 Query: 322 -----------GISNVKWFG----VEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLML 456 G+ K FG + +Y LV++ LG L+ + N +L ++V+++ Sbjct: 68 EWKKSHNIKHVGLITCKAFGLYKSINVEYRFLVINRLGADLDAVIRANNNRLPKRSVMLI 127 Query: 457 ADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 +++N ++F+H + + H DIK N ++ + N++Y++D+GL K+ S +H+P+ Sbjct: 128 GIEILNTIQFMHEQGYSHGDIKASNIVLDQIDK-NKLYLVDYGLVSKF--MSNGEHVPF 183
>VPK1_VACCA (O57252) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 67.8 bits (164), Expect = 3e-11 Identities = 48/179 (26%), Positives = 90/179 (50%), Gaps = 18/179 (10%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLY-RVLQGGT-- 321 N++ +G +G G FG IY TN + +K+E + L E Y RVL+ Sbjct: 14 NQWVVGPLIGKGGFGSIYT-TN---DNNYVVKIE--PKANGSLFTEQAFYTRVLKPSVIE 67 Query: 322 -----------GISNVKWFG----VEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLML 456 G+ K FG + +Y LV++ LG L+ + N +L ++V+++ Sbjct: 68 EWKKSHNIKHVGLITCKAFGLYKSINVEYRFLVINRLGADLDAVIRANNNRLPKRSVMLI 127 Query: 457 ADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 +++N ++F+H + + H DIK N ++ + N++Y++D+GL K+ S +H+P+ Sbjct: 128 GIEILNTIQFMHEQGYSHGDIKASNIVLDQIDK-NKLYLVDYGLVSKF--MSNGEHVPF 183
>VPK1_VACCC (P20505) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 67.4 bits (163), Expect = 3e-11 Identities = 48/179 (26%), Positives = 90/179 (50%), Gaps = 18/179 (10%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLY-RVLQGGT-- 321 N++ +G +G G FG IY TN + +K+E + L E Y RVL+ Sbjct: 14 NQWVVGPLIGKGGFGSIYT-TN---DNNYVVKIE--PKANGSLFTEQAFYTRVLKPSVIE 67 Query: 322 -----------GISNVKWFG----VEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLML 456 G+ K FG + +Y LV++ LG L+ + N +L ++V+++ Sbjct: 68 EWKKSHNIKHVGLITCKAFGLYKSINVEYRFLVINRLGVDLDAVIRANNNRLPKRSVMLI 127 Query: 457 ADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 +++N ++F+H + + H DIK N ++ + N++Y++D+GL K+ S +H+P+ Sbjct: 128 GIEILNTIQFMHEQGYSHGDIKASNIVLDQIDK-NKLYLVDYGLVSKF--MSNGEHVPF 183
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 66.6 bits (161), Expect = 6e-11 Identities = 51/176 (28%), Positives = 91/176 (51%), Gaps = 5/176 (2%) Frame = +1 Query: 88 NLGGGSVACVRARPPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTK 267 +LG + + P +P VGN YRL R +G G+F ++ L ++ T EVAIK+ + Sbjct: 37 SLGARCRNSIASCPEEQPHVGN-YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL 95 Query: 268 HPQLLYESKLYRVLQGGTGISN---VKWFGVEGDYNVLVMDVLGPSLEDLFSF--CNRKL 432 +P L KL+R ++ G+++ VK F V L + + S ++F + + ++ Sbjct: 96 NPSSL--QKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRM 153 Query: 433 SLKTVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 K Q+++ V + H K+ +HRD+K +N L L AN + + DFG + ++ Sbjct: 154 KEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLL--LDAEAN-IKIADFGFSNEF 206
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 66.6 bits (161), Expect = 6e-11 Identities = 51/176 (28%), Positives = 91/176 (51%), Gaps = 5/176 (2%) Frame = +1 Query: 88 NLGGGSVACVRARPPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTK 267 +LG + + P +P VGN YRL R +G G+F ++ L ++ T EVAIK+ + Sbjct: 37 SLGARCRNSIASCPEEQPHVGN-YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL 95 Query: 268 HPQLLYESKLYRVLQGGTGISN---VKWFGVEGDYNVLVMDVLGPSLEDLFSF--CNRKL 432 +P L KL+R ++ G+++ VK F V L + + S ++F + + ++ Sbjct: 96 NPSSL--QKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRM 153 Query: 433 SLKTVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 K Q+++ V + H K+ +HRD+K +N L L AN + + DFG + ++ Sbjct: 154 KEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLL--LDAEAN-IKIADFGFSNEF 206
>VPK1_VARV (P33800) Serine/threonine-protein kinase 1 (EC 2.7.11.1)| Length = 300 Score = 66.2 bits (160), Expect = 8e-11 Identities = 47/179 (26%), Positives = 90/179 (50%), Gaps = 18/179 (10%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLY-RVLQGGT-- 321 N++ +G +G G FG IY TN + +K+E + L E Y RVL+ Sbjct: 14 NQWVVGPLIGKGGFGSIYT-TN---DNNYVVKIE--PKANGSLFTEQAFYTRVLKPSVIE 67 Query: 322 -----------GISNVKWFG----VEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLML 456 G+ K FG + +Y LV++ LG L+ + N +L ++V+++ Sbjct: 68 EWKKSHHISHVGVITCKAFGLYKSINTEYRFLVINRLGVDLDAVIRANNNRLPKRSVMLV 127 Query: 457 ADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 +++N ++F+H + + H +IK N ++ + N++Y++D+GL K+ S +H+P+ Sbjct: 128 GIEILNTIQFMHEQGYSHGNIKASNIVLDQMDK-NKLYLVDYGLVSKF--MSNGEHVPF 183
>PKN1_MYXXA (P33973) Serine/threonine-protein kinase pkn1 (EC 2.7.11.1)| Length = 693 Score = 65.9 bits (159), Expect = 1e-10 Identities = 55/186 (29%), Positives = 93/186 (50%), Gaps = 11/186 (5%) Frame = +1 Query: 70 P*LDALNLGGGSVACVRARPPME---PRVG---NKYRLGRKLGSGSFGEIYLGTNVQTNE 231 P L ++ G A R P +E P VG +RL R+LG G G +YLG +V Sbjct: 24 PTLVRADVRAGGTAHPRCAPVVEAQDPLVGVRCGSFRLVRRLGRGGMGAVYLGEHVSIGS 83 Query: 232 EVAIKLENVK-TKHPQLL--YESKLYRV-LQGGTGISNVKWFGVEGDYNVLVMDVLGPSL 399 VA+K+ + T +P+L+ + ++ V L G I ++ L+M+ L + Sbjct: 84 RVAVKVLHAHLTMYPELVQRFHAEARAVNLIGHENIVSIFDMDATPPRPYLIMEFLDGA- 142 Query: 400 EDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRDIKPDN-FLMGLGKRANQVYMI 576 L ++ L+ V+ + Q+ + ++ H++ +HRD+KPDN FL+ A V ++ Sbjct: 143 -PLSAWVGTPLAAGAVVSVLSQVCDALQAAHARGIVHRDLKPDNIFLVRRNGNAPFVKVL 201 Query: 577 DFGLAK 594 DFG+AK Sbjct: 202 DFGIAK 207
>CSK2A_DICDI (Q02720) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II alpha| subunit) Length = 337 Score = 65.9 bits (159), Expect = 1e-10 Identities = 45/150 (30%), Positives = 81/150 (54%), Gaps = 2/150 (1%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y + RK+G G + E++ G N++ NE+ IK L+ VK K ++ E K+ + L GG I Sbjct: 47 YEIIRKIGRGKYSEVFEGANIKNNEKCVIKVLKPVKKK--KIKREIKILQNLCGGPNI-- 102 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDL-FSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLH 510 + + V D ++ + + F + L+ V ++++ ++F HS +H Sbjct: 103 ITLYDVVRDPQSKTPSLIFEYINNTDFKHLSPTLTDFDVRYYIRELLHALDFCHSNGIMH 162 Query: 511 RDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 RD+KP N ++ KR ++Y+ID+GLA+ Y Sbjct: 163 RDVKPSNVMIDHQKR--KLYLIDWGLAEFY 190
>CSK2A_CAEEL (P18334) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II alpha| subunit) Length = 360 Score = 65.5 bits (158), Expect = 1e-10 Identities = 47/157 (29%), Positives = 82/157 (52%), Gaps = 9/157 (5%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y+L RKLG G + E++ G + T+E+V +K L+ VK K ++ E K+ L+GGT I Sbjct: 38 YQLVRKLGRGKYSEVFEGFKMSTDEKVVVKILKPVKKK--KIKREIKILENLRGGTNIIT 95 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------QMINRVEFI 489 + +V D + + +F N + L+D +++ ++F Sbjct: 96 LL---------DVVKDPISRTPALIFEHVNNSDFKQLYQTLSDYDIRYYLYELLKALDFC 146 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 HS+ +HRD+KP N ++ KR ++ +ID+GLA+ Y Sbjct: 147 HSQGIMHRDVKPHNVMIDAEKR--ELRLIDWGLAEFY 181
>YMX8_CAEEL (P34516) Putative serine/threonine-protein kinase K06H7.1 (EC| 2.7.11.1) Length = 346 Score = 65.1 bits (157), Expect = 2e-10 Identities = 43/156 (27%), Positives = 81/156 (51%), Gaps = 4/156 (2%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIY-LGTNVQTNEEVAIKLENVKTKHPQLL-YESKLYRVLQGG 318 VG +Y++ +KLG G G ++ + + + A+K+E +L E ++ L Sbjct: 16 VGKRYKVVQKLGEGGCGSVFKVEDTSEKGQHYALKVEFKSQDAGNILKMEVQILSQLISK 75 Query: 319 TGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSK 498 ++ G + Y+ +VM +LG SL+ L L++ T + + ++ ++ +H Sbjct: 76 KHVAKCVASGKKERYSYMVMTLLGESLDSLLKKHGPFLNVSTQVRIGICILFGIKQVHDI 135 Query: 499 SFLHRDIKPDNFLMGLGKRANQVY--MIDFGLAKKY 600 +LHRD+KP N MG A++ Y ++DFGLA++Y Sbjct: 136 GYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQY 171
>CDC7_MOUSE (Q9Z0H0) Cell division cycle 7-related protein kinase (EC 2.7.11.1)| (CDC7-related kinase) (muCdc7) Length = 564 Score = 65.1 bits (157), Expect = 2e-10 Identities = 48/160 (30%), Positives = 79/160 (49%), Gaps = 3/160 (1%) Frame = +1 Query: 139 PRVGNKYRLGRKLGSGSFGEIYLGT-NVQTNEEVAIKLEN-VKTKHP-QLLYESKLYRVL 309 P++ N ++ K+G G+F +YL T +Q E I L++ + T HP ++ E + V Sbjct: 46 PQLVNVSKIKDKIGEGTFSSVYLATAQLQEGHEEKIALKHLIPTSHPMRIAAELQCLTVA 105 Query: 310 QGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFI 489 G + +K+ + D+ V+ M L E N LS + V + ++ I Sbjct: 106 GGQDNVMGLKYCFRKNDHVVIAMPYL--EHESFLDILN-SLSFQEVREYMYNLFVALKRI 162 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 H +HRD+KP NFL +R + ++DFGLA+ RDT Sbjct: 163 HQFGIVHRDVKPSNFL--YNRRLKKYALVDFGLAQGTRDT 200
>CSK22_MOUSE (O54833) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 350 Score = 65.1 bits (157), Expect = 2e-10 Identities = 49/165 (29%), Positives = 84/165 (50%), Gaps = 11/165 (6%) Frame = +1 Query: 139 PRVGNK--YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVL 309 P GN+ Y+L RKLG G + E++ N+ NE V +K L+ VK K ++ E K+ L Sbjct: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENL 89 Query: 310 QGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------Q 465 +GGT I +K V D + + +F + N + +L D + Sbjct: 90 RGGTNI--IKLIDT-------VKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYE 140 Query: 466 MINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 ++ +++ HSK +HRD+KP N + + + ++ +ID+GLA+ Y Sbjct: 141 LLKALDYCHSKGIMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFY 183
>CSK22_HUMAN (P19784) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 350 Score = 65.1 bits (157), Expect = 2e-10 Identities = 49/165 (29%), Positives = 84/165 (50%), Gaps = 11/165 (6%) Frame = +1 Query: 139 PRVGNK--YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVL 309 P GN+ Y+L RKLG G + E++ N+ NE V +K L+ VK K ++ E K+ L Sbjct: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENL 89 Query: 310 QGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------Q 465 +GGT I +K V D + + +F + N + +L D + Sbjct: 90 RGGTNI--IKLIDT-------VKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYE 140 Query: 466 MINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 ++ +++ HSK +HRD+KP N + + + ++ +ID+GLA+ Y Sbjct: 141 LLKALDYCHSKGIMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFY 183
>CSK22_BOVIN (P20427) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 350 Score = 65.1 bits (157), Expect = 2e-10 Identities = 49/165 (29%), Positives = 84/165 (50%), Gaps = 11/165 (6%) Frame = +1 Query: 139 PRVGNK--YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVL 309 P GN+ Y+L RKLG G + E++ N+ NE V +K L+ VK K ++ E K+ L Sbjct: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENL 89 Query: 310 QGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------Q 465 +GGT I +K V D + + +F + N + +L D + Sbjct: 90 RGGTNI--IKLIDT-------VKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYE 140 Query: 466 MINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 ++ +++ HSK +HRD+KP N + + + ++ +ID+GLA+ Y Sbjct: 141 LLKALDYCHSKGIMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFY 183
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 64.7 bits (156), Expect = 2e-10 Identities = 40/156 (25%), Positives = 79/156 (50%), Gaps = 6/156 (3%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK------LENVKTKHPQLLYESKLYRVLQG 315 KY G+ LG+G+FG + N +T E+VA+K L+ K + L E + + L Sbjct: 36 KYVFGKTLGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLHH 95 Query: 316 GTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHS 495 ++ WF + + ++ G L D K + + + + ++++ V+++HS Sbjct: 96 PNIVAFKDWFESKDKFYIITQLAKGGELFDRI-LKKGKFTEEDAVRILVEILSAVKYMHS 154 Query: 496 KSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYR 603 ++ +HRD+KP+N L + + + DFG+AK+ + Sbjct: 155 QNIVHRDLKPENLLYIDKSDESPLVVADFGIAKRLK 190
>CSK22_CHICK (P21869) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 350 Score = 64.3 bits (155), Expect = 3e-10 Identities = 48/165 (29%), Positives = 83/165 (50%), Gaps = 11/165 (6%) Frame = +1 Query: 139 PRVGNK--YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVL 309 P GN+ Y+L RKLG G + E++ N+ NE V +K L+ VK K ++ E K+ L Sbjct: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENL 89 Query: 310 QGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------Q 465 +GGT I N+ V D + + +F + N + +L D + Sbjct: 90 RGGTNIINL---------IDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYE 140 Query: 466 MINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 ++ +++ HS +HRD+KP N + + + ++ +ID+GLA+ Y Sbjct: 141 LLKALDYCHSMGIMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFY 183
>PKND_CHLTR (O84303) Serine/threonine-protein kinase pknD (EC 2.7.11.1)| Length = 934 Score = 63.9 bits (154), Expect = 4e-10 Identities = 51/168 (30%), Positives = 80/168 (47%), Gaps = 22/168 (13%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-----LENVKTKHPQLLYESKL------- 297 +Y L R +G G GE+YL + + VA+K L + L E+K+ Sbjct: 3 RYELIRLIGKGGMGEVYLAHDKACSRRVALKRIREDLSGNALLRQRFLREAKIAADLIHP 62 Query: 298 -----YRVLQGGTGI----SNVKWFGVEGDY-NVLVMDVLGPSLEDLFSFCNRKLSLKTV 447 Y + G + ++ F ++ +V +VL LE+ K S+K+ Sbjct: 63 GIVPVYSICSDGEAVYYTMPYIEGFSLKSLLKSVWQKEVLSKELEE-------KTSVKSF 115 Query: 448 LMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 L + D++ VE+IHSK LHRD+KPDN L+GL +V +ID+G A Sbjct: 116 LPIFDKICATVEYIHSKGVLHRDLKPDNILLGL---FGEVVIIDWGAA 160
>VRK2_MOUSE (Q8BN21) Serine/threonine-protein kinase VRK2 (EC 2.7.11.1)| (Vaccinia-related kinase 2) Length = 503 Score = 63.5 bits (153), Expect = 5e-10 Identities = 56/181 (30%), Positives = 83/181 (45%), Gaps = 23/181 (12%) Frame = +1 Query: 148 GNKYRLGRKLGSGSFGEIYLG--TNVQTNE-EVAIKLENVKTKHPQLLYESKLYRVLQGG 318 GN++ LG+ +GSG FG IYL TN + IKLE ++ L E K Y+ Sbjct: 26 GNRWALGKMIGSGGFGLIYLAFPTNKPNKDARHVIKLEY--QENGPLFSELKFYQRAAKR 83 Query: 319 TGISNVKW----------------FGVEG----DYNVLVMDVLGPSLEDLFSFCNRKLSL 438 I KW FG+ Y +VM+ LG L+ L N Sbjct: 84 ECIQ--KWIQQRKLDYLGIPVFYGFGLTDFKGRSYRFMVMERLGIDLQKLLDQ-NGGFKK 140 Query: 439 KTVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTH 618 TVL L +M++ +E+IH ++H DIK N L+ ++VY+ D+GL+ +Y H Sbjct: 141 LTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLDF-TNPDRVYLADYGLSYRYCPNGNH 199 Query: 619 Q 621 + Sbjct: 200 K 200
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 63.2 bits (152), Expect = 6e-10 Identities = 51/186 (27%), Positives = 87/186 (46%), Gaps = 22/186 (11%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK------LENV-----------KTKH 270 ++ +KY + KLG G++G +Y G + TN+ AIK L+N+ K H Sbjct: 66 KLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDH 125 Query: 271 PQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFC--NRKLSLKT 444 P ++ KLY + +Y L+M++ S +LF N + K Sbjct: 126 PNIV---KLYETYEND-------------NYIYLIMELC--SGRELFDSIIENGSFTEKN 167 Query: 445 VLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY---RDTST 615 + Q+ + + ++HS + +HRD+KP+NFL + + + +IDFGL+K T+T Sbjct: 168 AATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTT 227 Query: 616 HQHIPY 633 PY Sbjct: 228 KAGTPY 233
>CSK2A_THEPA (P28547) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| Length = 348 Score = 63.2 bits (152), Expect = 6e-10 Identities = 45/154 (29%), Positives = 80/154 (51%), Gaps = 2/154 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGT 321 V + Y + RK+G G F E++ G N T ++ IK L+ VK K ++ E K+ + L+GG Sbjct: 51 VPDSYEIVRKIGRGKFSEVFEGINTVTKDKCVIKILKPVKKK--KIKREIKILQNLRGGP 108 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDL-FSFCNRKLSLKTVLMLADQMINRVEFIHSK 498 I +K + D ++ + + F LS++ + Q++ + + HS+ Sbjct: 109 NI--IKLLDIVKDPQSRTPSLIFEHVNNTDFKTLYPTLSIQDIKYYIYQLLKAMNYCHSQ 166 Query: 499 SFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 +HRDIKP N ++ K+ + +ID+GLA+ Y Sbjct: 167 GIMHRDIKPHNVMIDHEKKI--LRLIDWGLAEFY 198
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 63.2 bits (152), Expect = 6e-10 Identities = 52/175 (29%), Positives = 83/175 (47%), Gaps = 20/175 (11%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT------------------- 264 RVGN Y++ + LG GSFG++ L +V T ++VA+K+ N K Sbjct: 35 RVGN-YQIVKTLGEGSFGKVKLAYHVTTGQKVALKIINKKVLAKSDMQGRIEREISYLRL 93 Query: 265 -KHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLK 441 +HP ++ KLY V++ D ++V++ G L D + K+S + Sbjct: 94 LRHPHII---KLYDVIK-------------SKDEIIMVIEYAGNELFD-YIVQRNKMSEQ 136 Query: 442 TVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 Q+I+ VE+ H +HRD+KP+N L L + N V + DFGL+ D Sbjct: 137 EARRFFQQIISAVEYCHRHKIVHRDLKPENLL--LDEHLN-VKIADFGLSNIMTD 188
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 63.2 bits (152), Expect = 6e-10 Identities = 51/186 (27%), Positives = 87/186 (46%), Gaps = 22/186 (11%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK------LENV-----------KTKH 270 ++ +KY + KLG G++G +Y G + TN+ AIK L+N+ K H Sbjct: 66 KLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDH 125 Query: 271 PQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFC--NRKLSLKT 444 P ++ KLY + +Y L+M++ S +LF N + K Sbjct: 126 PNIV---KLYETYEND-------------NYIYLIMELC--SGRELFDSIIENGSFTEKN 167 Query: 445 VLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY---RDTST 615 + Q+ + + ++HS + +HRD+KP+NFL + + + +IDFGL+K T+T Sbjct: 168 AATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTT 227 Query: 616 HQHIPY 633 PY Sbjct: 228 KAGTPY 233
>PKND_CHLMU (Q9PK92) Serine/threonine-protein kinase pknD (EC 2.7.11.1)| Length = 934 Score = 62.4 bits (150), Expect = 1e-09 Identities = 50/169 (29%), Positives = 79/169 (46%), Gaps = 23/169 (13%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-----LENVKTKHPQLLYESKL------- 297 +Y L R +G G GE+YL + + VA+K L + + L E+K+ Sbjct: 3 RYELIRLIGRGGMGEVYLAHDKACSRRVALKKIREDLSDNPLLRKRFLREAKIAADLIHP 62 Query: 298 -----YRVLQGGTGISNVKWFGVEGDY------NVLVMDVLGPSLEDLFSFCNRKLSLKT 444 Y + G + + +EG +V ++L LE+ K S+K Sbjct: 63 GIVPVYSICSDGESVYYTMPY-IEGFSLKHLLKSVWQKEILSKELEE-------KTSVKA 114 Query: 445 VLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 L + D++ VE+IHSK LHRD+KPDN L+GL +V ++D+G A Sbjct: 115 FLPIFDKICATVEYIHSKGVLHRDLKPDNILLGL---FGEVVIVDWGAA 160
>PIM1_RAT (P26794) Proto-oncogene serine/threonine-protein kinase Pim-1 (EC| 2.7.11.1) Length = 313 Score = 62.0 bits (149), Expect = 1e-09 Identities = 56/188 (29%), Positives = 92/188 (48%), Gaps = 14/188 (7%) Frame = +1 Query: 88 NLGGGSVACVRARPPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK------- 246 +L +A + + P+E ++Y++G LGSG FG +Y G V N VAIK Sbjct: 19 DLHANKLAPGKEKEPLE----SQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRI 74 Query: 247 -----LENVKTKHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLF 411 L N T+ P + L +V G +G+ + + D VL+++ P ++DLF Sbjct: 75 SDWGELPN-GTRVPMEVV--LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLF 130 Query: 412 SFCNRKLSLKTVLMLAD--QMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFG 585 F + +L+ L + Q++ V H+ LHRDIK +N L+ L + ++ +IDFG Sbjct: 131 DFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFG 188 Query: 586 LAKKYRDT 609 +DT Sbjct: 189 SGALLKDT 196
>CSK23_ARATH (O64817) Probable casein kinase II subunit alpha (EC 2.7.11.1) (CK| II) Length = 333 Score = 62.0 bits (149), Expect = 1e-09 Identities = 44/150 (29%), Positives = 79/150 (52%), Gaps = 2/150 (1%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y + RK+G G + E++ G NV TNE IK L+ VK K ++ E K+ + L GG I Sbjct: 34 YEVVRKVGRGKYSEVFEGKNVNTNERCVIKILKPVKKK--KIKREIKILQNLCGGPNI-- 89 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDL-FSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLH 510 VK + + D + ++ + + F L+ + +++ ++F HS+ +H Sbjct: 90 VKLYDIVRDEHSKTPSLVFEFVNSVDFKVLYPTLTDYDIRYYIYELLKALDFCHSQGIMH 149 Query: 511 RDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 RD+KP N + + + ++ +ID+GLA+ Y Sbjct: 150 RDVKPHNVM--IDHQLRKLRLIDWGLAEFY 177
>CSK2A_THEAN (Q4U925) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| (TaCKIIalpha) Length = 348 Score = 62.0 bits (149), Expect = 1e-09 Identities = 44/154 (28%), Positives = 80/154 (51%), Gaps = 2/154 (1%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGT 321 V + Y + RK+G G F E++ G N T ++ IK L+ VK K ++ E K+ + L+GG Sbjct: 51 VPDSYEIVRKIGRGKFSEVFEGLNTVTKDKCVIKILKPVKKK--KIKREIKILQNLRGGP 108 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDL-FSFCNRKLSLKTVLMLADQMINRVEFIHSK 498 I +K + D ++ + + F L+++ + Q++ + + HS+ Sbjct: 109 NI--IKLLDIVKDPQSRTPSLIFEHVNNTDFKTLYPTLTIQDIKYYIYQLLKAMNYCHSQ 166 Query: 499 SFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 +HRDIKP N ++ K+ + +ID+GLA+ Y Sbjct: 167 GIMHRDIKPHNVMIDHEKKI--LRLIDWGLAEFY 198
>NHK1_DROME (Q7KRY6) Nucleosomal histone kinase 1 (EC 2.7.11.1) (Protein| baellchen) Length = 599 Score = 62.0 bits (149), Expect = 1e-09 Identities = 49/174 (28%), Positives = 78/174 (44%), Gaps = 25/174 (14%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNV-QTNEEVAIKLE----------------NVKTKH-PQL 279 ++R+G +G G FGEIY V + N + +K E N K + Q Sbjct: 46 QWRIGPSIGVGGFGEIYAACKVGEKNYDAVVKCEPHGNGPLFVEMHFYLRNAKLEDIKQF 105 Query: 280 LYESKL------YRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLK 441 + + L Y + G ++ K + +VM G L ++L Sbjct: 106 MQKHGLKSLGMPYILANGSVEVNGEK-------HRFIVMPRYGSDLTKFLEQNGKRLPEG 158 Query: 442 TVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGK-RANQVYMIDFGLAKKY 600 TV LA QM++ +++HS ++H D+K N L+GL K A Q Y++DFGLA + Sbjct: 159 TVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHF 212
>ICK_HUMAN (Q9UPZ9) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2) Length = 632 Score = 62.0 bits (149), Expect = 1e-09 Identities = 45/155 (29%), Positives = 75/155 (48%), Gaps = 4/155 (2%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT---KHPQLLYESKLYRVLQGGT 321 N+Y R+LG G++G + LG ++++ E +AIK K + L E K + L Sbjct: 2 NRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHAN 61 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 + +K E D+ + + + +L L N+ + + Q++ + FIH Sbjct: 62 -VVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG 120 Query: 502 FLHRDIKPDNFL-MGLGKRANQVYMIDFGLAKKYR 603 F HRD+KP+N L MG V + DFGLA++ R Sbjct: 121 FFHRDLKPENLLCMG----PELVKIADFGLAREIR 151
>CDK9_CHICK (Q5ZKN1) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 62.0 bits (149), Expect = 1e-09 Identities = 47/161 (29%), Positives = 80/161 (49%), Gaps = 11/161 (6%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGG 318 +KY K+G G+FGE++ + QT ++VA+K +EN K P L E K+ ++L+ Sbjct: 17 SKYEKLAKIGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 319 TGISNVKWFGVEGD-YN------VLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINR 477 ++ ++ + YN LV D L L S + K +L + + ++N Sbjct: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNTHVKFTLSEIKKVMQMLLNG 136 Query: 478 VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 + +IH LHRD+K N L+ R + + DFGLA+ + Sbjct: 137 LYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAF 174
>CDK9_XENTR (Q6GLD8) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 376 Score = 61.6 bits (148), Expect = 2e-09 Identities = 48/165 (29%), Positives = 79/165 (47%), Gaps = 15/165 (9%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGG 318 +KY K+G G+FGE++ + QT ++VA+K +EN K P L E K+ ++L+ Sbjct: 17 SKYERLAKIGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 319 TGISNV-----KWFGVEGDYN------VLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQ 465 ++ + K YN LV D L L S + K +L + + Sbjct: 77 NVVNLIEICRTKISPTANQYNRCKGTIFLVFDFCEHDLAGLLSNAHVKFTLSEIKKVMQM 136 Query: 466 MINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 ++N + +IH LHRD+K N L+ R + + DFGLA+ + Sbjct: 137 LLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAF 178
>CDK9A_XENLA (Q4V862) Cell division protein kinase 9-A (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9-A) Length = 376 Score = 61.6 bits (148), Expect = 2e-09 Identities = 48/165 (29%), Positives = 79/165 (47%), Gaps = 15/165 (9%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGG 318 +KY K+G G+FGE++ + QT ++VA+K +EN K P L E K+ ++L+ Sbjct: 17 SKYERLAKIGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 319 TGISNV-----KWFGVEGDYN------VLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQ 465 ++ + K YN LV D L L S + K +L + + Sbjct: 77 NVVNLIEICRTKVSPTANQYNRCKGTIFLVFDFCEHDLAGLLSNAHVKFTLSEIKKVMQM 136 Query: 466 MINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 ++N + +IH LHRD+K N L+ R + + DFGLA+ + Sbjct: 137 LLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAF 178
>GSK3H_DROME (P83101) Putative glycogen synthase kinase-3 homolog (EC 2.7.11.26)| (GSK-3) (Protein gasket) Length = 501 Score = 61.6 bits (148), Expect = 2e-09 Identities = 51/158 (32%), Positives = 79/158 (50%), Gaps = 11/158 (6%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK--LENVKTKHPQLLYESKLYRVLQGGTGIS 330 Y + +G+GSFG ++ V +NE VAIK L++ + K+ +L KL I Sbjct: 33 YTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKVLQDRRFKNRELQIMRKLRH-----DNII 87 Query: 331 NVKWF----GVEGD--YNVLVMDVLGPSL---EDLFSFCNRKLSLKTVLMLADQMINRVE 483 +KWF G + D Y LVM+ L +L E ++ + L + V + Q++ + Sbjct: 88 TLKWFFFSSGEKRDEVYLNLVMEFLPETLYKVERQYARAKQTLPVNFVRLYMYQLLRSMG 147 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKK 597 ++HS F HRDIKP N L L + + DFG AK+ Sbjct: 148 YLHSLGFCHRDIKPQNML--LDSETGVLKLCDFGSAKQ 183
>PIM1_HUMAN (P11309) Proto-oncogene serine/threonine-protein kinase Pim-1 (EC| 2.7.11.1) Length = 404 Score = 61.6 bits (148), Expect = 2e-09 Identities = 54/178 (30%), Positives = 88/178 (49%), Gaps = 14/178 (7%) Frame = +1 Query: 118 RARPPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK------------LENVK 261 + + P+E ++Y++G LGSG FG +Y G V N VAIK L N Sbjct: 120 KEKEPLE----SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPN-G 174 Query: 262 TKHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLK 441 T+ P + L +V G +G+ + + D VL+++ P ++DLF F + +L+ Sbjct: 175 TRVPMEVV--LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQ 231 Query: 442 TVLMLAD--QMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 L + Q++ V H+ LHRDIK +N L+ L + ++ +IDFG +DT Sbjct: 232 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLKDT 287
>ICK_RAT (Q62726) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (MAK-related kinase) (MRK) Length = 629 Score = 61.2 bits (147), Expect = 2e-09 Identities = 45/155 (29%), Positives = 75/155 (48%), Gaps = 4/155 (2%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT---KHPQLLYESKLYRVLQGGT 321 N+Y ++LG G++G + LG ++++ E +AIK K + L E K + L Sbjct: 2 NRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHAN 61 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 I +K E D+ + + + +L L N+ + + Q++ + FIH Sbjct: 62 -IVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG 120 Query: 502 FLHRDIKPDNFL-MGLGKRANQVYMIDFGLAKKYR 603 F HRD+KP+N L MG V + DFGLA++ R Sbjct: 121 FFHRDLKPENLLCMG----PELVKIADFGLAREIR 151
>ICK_MOUSE (Q9JKV2) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK) Length = 629 Score = 61.2 bits (147), Expect = 2e-09 Identities = 45/155 (29%), Positives = 75/155 (48%), Gaps = 4/155 (2%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT---KHPQLLYESKLYRVLQGGT 321 N+Y ++LG G++G + LG ++++ E +AIK K + L E K + L Sbjct: 2 NRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHAN 61 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 I +K E D+ + + + +L L N+ + + Q++ + FIH Sbjct: 62 -IVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG 120 Query: 502 FLHRDIKPDNFL-MGLGKRANQVYMIDFGLAKKYR 603 F HRD+KP+N L MG V + DFGLA++ R Sbjct: 121 FFHRDLKPENLLCMG----PELVKIADFGLAREIR 151
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 61.2 bits (147), Expect = 2e-09 Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 6/156 (3%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTG 324 +GN+Y + K+G G ++Y N VAIK+ + + + K R Q Sbjct: 6 LGNRYEILEKIGEGGMAKVYKAKCHLLNRIVAIKILRPEFAADEN-FVKKFKRESQAAAS 64 Query: 325 ISNVKWFGV-----EGDYNVLVMD-VLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEF 486 +S+ G+ EGD +VM+ V G +L++L L +K + +A Q+ ++ Sbjct: 65 LSHPNIVGIYDVGQEGDIYYIVMEYVKGRTLKELIRENGGPLEVKRAVEIASQVCRALDH 124 Query: 487 IHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAK 594 H +HRDIKP N L+ + V + DFG+A+ Sbjct: 125 AHKNKIIHRDIKPQNILV---TDEDVVKVTDFGIAR 157
>KC47_ORYSA (P29620) CDC2+/CDC28-related protein kinase R2 (EC 2.7.11.22)| Length = 424 Score = 61.2 bits (147), Expect = 2e-09 Identities = 51/167 (30%), Positives = 78/167 (46%), Gaps = 7/167 (4%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENV-KTKHP---QLLYESKLYRVL 309 RV ++Y LG G++G ++ + +T VAIK + K K L E KL + L Sbjct: 14 RVADRYLKREVLGEGTYGVVFKAVDTKTGNTVAIKKIRLGKYKEGVNFTALREIKLLKEL 73 Query: 310 QGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFI 489 + I + F +G+ + LV + + LE + N LS M+ + F Sbjct: 74 KDSNIIELIDAFPYKGNLH-LVFEFMETDLEAVIRDRNIVLSPADTKSYIQMMLKGLAFC 132 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTS---THQ 621 H K LHRD+KP+N L+G Q+ + DFGLA+ + THQ Sbjct: 133 HKKWVLHRDMKPNNLLIGAD---GQLKLADFGLARIFGSPERNFTHQ 176
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 61.2 bits (147), Expect = 2e-09 Identities = 44/154 (28%), Positives = 81/154 (52%), Gaps = 3/154 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISN 333 KY K+G G+ G +Y + TN VAIK N++ + + L +++ V++G + Sbjct: 619 KYANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELIINEIL-VMKGSKHPNI 677 Query: 334 VKW---FGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 V + + ++GD V++ + G SL D+ + C L+ + + + ++ +EF+HSK Sbjct: 678 VNFIDSYVLKGDLWVIMEYMEGGSLTDVVTHCI--LTEGQIGAVCRETLSGLEFLHSKGV 735 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 LHRDIK DN L+ + + + DFG + + Sbjct: 736 LHRDIKSDNILLSM---EGDIKLTDFGFCAQINE 766
>PIM1_FELCA (Q95LJ0) Proto-oncogene serine/threonine-protein kinase pim-1 (EC| 2.7.11.1) Length = 313 Score = 61.2 bits (147), Expect = 2e-09 Identities = 54/178 (30%), Positives = 88/178 (49%), Gaps = 14/178 (7%) Frame = +1 Query: 118 RARPPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK------------LENVK 261 + + P+E ++Y++G LGSG FG +Y G V N VAIK L N Sbjct: 29 KEKEPLE----SQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPN-G 83 Query: 262 TKHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLK 441 T+ P + L +V G +G+ + + D VL+++ P ++DLF F + +L+ Sbjct: 84 TRVPMEVV--LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQ 140 Query: 442 TVLMLAD--QMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 L + Q++ V H+ LHRDIK +N L+ L + ++ +IDFG +DT Sbjct: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLKDT 196
>PIM1_BOVIN (Q9N0P9) Proto-oncogene serine/threonine-protein kinase pim-1 (EC| 2.7.11.1) Length = 313 Score = 60.8 bits (146), Expect = 3e-09 Identities = 54/178 (30%), Positives = 87/178 (48%), Gaps = 14/178 (7%) Frame = +1 Query: 118 RARPPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK------------LENVK 261 + + P+E ++Y++G LGSG FG +Y G V N VAIK L N Sbjct: 29 KEKEPLE----SQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPN-G 83 Query: 262 TKHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLK 441 T+ P + L +V G +G+ + + D VL+++ P ++DLF F + +L+ Sbjct: 84 TRVPMEVV--LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQ 140 Query: 442 TVLMLAD--QMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 L + Q++ V H LHRDIK +N L+ L + ++ +IDFG +DT Sbjct: 141 EELARSFFWQVLEAVRHCHDCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLKDT 196
>TAOK3_PONPY (Q5R4F3) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 60.8 bits (146), Expect = 3e-09 Identities = 47/159 (29%), Positives = 70/159 (44%), Gaps = 5/159 (3%) Frame = +1 Query: 172 KLGSGSFGEIYLGTNVQTNEEVAIKL-----ENVKTKHPQLLYESKLYRVLQGGTGISNV 336 ++G GSFG +Y TN TNE VAIK + K +L E K R L+ I Sbjct: 29 EIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTI-EY 87 Query: 337 KWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 K ++ LVM+ S DL + L + + ++ + ++HS + +HRD Sbjct: 88 KGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRD 147 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 IK N L+ QV + DFG A ++ PY Sbjct: 148 IKAGNILL---TEPGQVKLADFGSASVASPANSFVGTPY 183
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 60.8 bits (146), Expect = 3e-09 Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 8/157 (5%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVK-----TKHPQLLYESKLYRVLQGG 318 +Y+ + LG GSFGE+ L + T E AIK+ + K T LL E +L ++L Sbjct: 68 QYKGIKILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLDH- 126 Query: 319 TGISNVKWFGVEGDYNVLVMDVL--GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 I + F + +Y LV DV G +++ S ++ + Q+++ + ++H Sbjct: 127 INIMKLYEFFEDNNYYYLVSDVYSGGELFDEIIS--RKRFYEVDAARIIKQVLSGITYMH 184 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVY-MIDFGLAKKY 600 + +HRD+KP+N L+ + + + +IDFGL+ + Sbjct: 185 KNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF 221
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 60.8 bits (146), Expect = 3e-09 Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 8/157 (5%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVK-----TKHPQLLYESKLYRVLQGG 318 +Y+ + LG GSFGE+ L + T E AIK+ + K T LL E +L ++L Sbjct: 68 QYKGIKILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLDH- 126 Query: 319 TGISNVKWFGVEGDYNVLVMDVL--GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 I + F + +Y LV DV G +++ S ++ + Q+++ + ++H Sbjct: 127 INIMKLYEFFEDNNYYYLVSDVYSGGELFDEIIS--RKRFYEVDAARIIKQVLSGITYMH 184 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVY-MIDFGLAKKY 600 + +HRD+KP+N L+ + + + +IDFGL+ + Sbjct: 185 KNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF 221
>MDE3_SCHPO (O43077) Sporulation protein kinase mde3 (EC 2.7.11.1)| (Mei4-dependent protein 3) Length = 559 Score = 60.8 bits (146), Expect = 3e-09 Identities = 57/163 (34%), Positives = 85/163 (52%), Gaps = 15/163 (9%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTN---EEVAIK-LENV---KTKHPQL-LYESKLYRV 306 ++Y + +KLG GSFG +YL + N E VA+K L+N K KH L L ES R Sbjct: 19 DRYLVKQKLGDGSFGTVYLAQRKEKNGLYETVAVKKLKNSSKPKPKHELLKLRESLALRK 78 Query: 307 LQGGTGISNVKWFGVEGDYNV-LVMDVLGPSLEDLFSFCNRKLSLK-TVLMLADQMINRV 480 + + ++ ++ N+ LVM+ + +L LF +L K T + Q+I+ + Sbjct: 79 ISKHPCLIDLLETFMDPYRNIFLVMEFMDCNLFQLFKRRQGRLFTKETAFNILLQIISGI 138 Query: 481 EFIHSKSFLHRDIKPDNFLMG--LGKRANQVYMI---DFGLAK 594 E IH F+HRDIKP+N L+ K + Y I DFGLA+ Sbjct: 139 EHIHKHGFMHRDIKPENILVKRISPKPISSRYSIKLGDFGLAR 181
>CSK2A_SPOFR (O76484) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II alpha| subunit) Length = 353 Score = 60.8 bits (146), Expect = 3e-09 Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 9/157 (5%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y+L RKLG G + E++ N+ NE+ +K L+ VK K ++ E K+ L+GGT I Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNNEKCVVKILKPVKKK--KIKREIKILENLRGGTNIIT 96 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------QMINRVEFI 489 ++ +V D + + +F N + L+D +++ +++ Sbjct: 97 LQ---------AVVKDPVSRTPALIFEHVNNTDFKQLYQTLSDYDIRYYLYELLKALDYC 147 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 HS +HRD+KP N ++ R ++ +ID+GLA+ Y Sbjct: 148 HSMGIMHRDVKPHNVMIDHDHR--KLRLIDWGLAEFY 182
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 60.8 bits (146), Expect = 3e-09 Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 5/161 (3%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQG-- 315 + N+Y++ ++G G +Y + N VA+K L++ T+ + +++ K Sbjct: 6 LSNRYKIEEEIGVGGTAVVYKAMDTLLNRHVAVKVLKHEFTEDEEFVFKFKREASAAARI 65 Query: 316 -GTGISNVKWFGVEGDYNVLVMD-VLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFI 489 I N+ G +G+ N +VM+ V G +L+ L N K+ ++ A Q+ + F Sbjct: 66 ANANIVNIYDVGADGNVNYIVMEYVAGKTLKKLIKE-NGKIEFNKIIDYATQIAKALNFA 124 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTS 612 H +HRDIKP N ++ + + + DFG+AK +++ Sbjct: 125 HKNGIVHRDIKPHNIMV---TDDDIIKVTDFGIAKASNEST 162
>CDK5_RAT (Q03114) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 60.5 bits (145), Expect = 4e-09 Identities = 44/159 (27%), Positives = 75/159 (47%), Gaps = 10/159 (6%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK----------LENVKTKHPQLLYESKLYR 303 KY K+G G++G ++ N +T+E VA+K + + + LL E K Sbjct: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVE 483 +++ + + K LV + L+ F CN L + V L Q++ + Sbjct: 63 IVRLHDVLHSDKKL-------TLVFEFCDQDLKKYFDSCNGDLDPEIVKSLLFQLLKGLG 115 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 F HS++ LHRD+KP N L+ R ++ + DFGLA+ + Sbjct: 116 FCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAF 151
>CIPK1_ORYSA (Q6X4A2) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1)| Length = 449 Score = 60.5 bits (145), Expect = 4e-09 Identities = 46/161 (28%), Positives = 83/161 (51%), Gaps = 6/161 (3%) Frame = +1 Query: 127 PPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL---ENVKTKH---PQLLYE 288 P ++ RVG KY LGR +G G+F ++ N + +E VAIK+ E V+ KH Q+ E Sbjct: 11 PKVKRRVG-KYELGRTIGEGTFAKVRFAKNTENDEPVAIKILDKEKVQ-KHRLVEQIRRE 68 Query: 289 SKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQM 468 ++++ + + G + +++ V G L ++ + N +L + Q+ Sbjct: 69 ICTMKLVKHPNVVRLFEVMGSKARIFIVLEYVTGGELFEIIA-TNGRLKEEEARKYFQQL 127 Query: 469 INRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 IN V++ HS+ HRD+K +N L+ + + + DFGL+ Sbjct: 128 INAVDYCHSRGVYHRDLKLENLLL---DASGNLKVSDFGLS 165
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 60.5 bits (145), Expect = 4e-09 Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 8/157 (5%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVK-----TKHPQLLYESKLYRVLQGG 318 +Y+ + LG GSFGE+ L + T E AIK+ + K T LL E +L ++L Sbjct: 68 QYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDH- 126 Query: 319 TGISNVKWFGVEGDYNVLVMDVL--GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 I + F + +Y LV DV G +++ S ++ + Q+++ + ++H Sbjct: 127 INIMKLYEFFEDNNYYYLVSDVYTGGELFDEIIS--RKRFYEIDAARIIKQILSGITYMH 184 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVY-MIDFGLAKKY 600 + +HRD+KP+N L+ + + + +IDFGL+ + Sbjct: 185 KNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF 221
>KC1D_BOVIN (P35508) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) (Fragment) Length = 42 Score = 60.5 bits (145), Expect = 4e-09 Identities = 26/32 (81%), Positives = 28/32 (87%) Frame = +1 Query: 541 GLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 GLGK+ N VY+IDFGLAKKYRD THQHIPYR Sbjct: 1 GLGKKGNLVYIIDFGLAKKYRDARTHQHIPYR 32
>CDK9_RAT (Q641Z4) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 60.5 bits (145), Expect = 4e-09 Identities = 47/160 (29%), Positives = 78/160 (48%), Gaps = 11/160 (6%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGGT 321 KY K+G G+FGE++ + QT ++VA+K +EN K P L E K+ ++L+ Sbjct: 18 KYEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 Query: 322 GISNVKWFGVEGD-YN------VLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRV 480 ++ ++ + YN LV D L L S K +L + + ++N + Sbjct: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 Query: 481 EFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 +IH LHRD+K N L+ R + + DFGLA+ + Sbjct: 138 YYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAF 174
>CDK9_MOUSE (Q99J95) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 60.5 bits (145), Expect = 4e-09 Identities = 47/160 (29%), Positives = 78/160 (48%), Gaps = 11/160 (6%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGGT 321 KY K+G G+FGE++ + QT ++VA+K +EN K P L E K+ ++L+ Sbjct: 18 KYEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 Query: 322 GISNVKWFGVEGD-YN------VLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRV 480 ++ ++ + YN LV D L L S K +L + + ++N + Sbjct: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 Query: 481 EFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 +IH LHRD+K N L+ R + + DFGLA+ + Sbjct: 138 YYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAF 174
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 60.5 bits (145), Expect = 4e-09 Identities = 48/177 (27%), Positives = 83/177 (46%), Gaps = 22/177 (12%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLEN--------------------VK 261 ++GN + + +G G+FG + GT++QT +VAIK+ N K Sbjct: 20 KIGN-FVIKETIGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQK 78 Query: 262 TKHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRK--LS 435 HP + ++L+RV+ + I LVM+++ +LFS+ RK L Sbjct: 79 LTHPHI---TRLFRVISTPSDI-------------FLVMELVSGG--ELFSYITRKGALP 120 Query: 436 LKTVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 ++ Q+I+ V + H+ +HRD+KP+N L+ K + + DFGL+ D Sbjct: 121 IRESRRYFQQIISGVSYCHNHMIVHRDLKPENLLLDANK---NIKIADFGLSNYMTD 174
>TAOK3_XENLA (Q6DD27) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 896 Score = 60.1 bits (144), Expect = 5e-09 Identities = 45/159 (28%), Positives = 71/159 (44%), Gaps = 5/159 (3%) Frame = +1 Query: 172 KLGSGSFGEIYLGTNVQTNEEVAIKL-----ENVKTKHPQLLYESKLYRVLQGGTGISNV 336 ++G GSFG +Y TN TNE VA+K + + K ++ E K + L+ I Sbjct: 29 EIGHGSFGAVYFATNSTTNEIVAVKKMSYSGKQMNEKWQDIIKEVKFLQQLKHPNTI-EY 87 Query: 337 KWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 K ++ LVM+ S DL + L + + + + ++HS + +HRD Sbjct: 88 KGCYLKDHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHNMIHRD 147 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 IK N L+ QV + DFG A K ++ PY Sbjct: 148 IKAGNILL---TEPGQVKLADFGSASKSSPANSFVGTPY 183
>KIN11_ARATH (P92958) SNF1-related protein kinase catalytic alpha subunit KIN11| (EC 2.7.11.1) (AKIN11) (AKIN alpha1) Length = 512 Score = 60.1 bits (144), Expect = 5e-09 Identities = 47/155 (30%), Positives = 74/155 (47%), Gaps = 5/155 (3%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVK-----TKHPQLLYESKLYRVLQGGT 321 Y+LG+ LG GSFG++ + +V T +VAIK+ N + ++ E K+ R+ Sbjct: 20 YKLGKTLGIGSFGKVKIAEHVVTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPH 79 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 I + D V++ V L D + +L Q+I+ VE+ H Sbjct: 80 IIRQYEVIETTSDIYVVMEYVKSGELFD-YIVEKGRLQEDEARNFFQQIISGVEYCHRNM 138 Query: 502 FLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 +HRD+KP+N L L R N + + DFGL+ RD Sbjct: 139 VVHRDLKPENLL--LDSRCN-IKIADFGLSNVMRD 170
>PAK1_HUMAN (Q13153) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 60.1 bits (144), Expect = 5e-09 Identities = 44/146 (30%), Positives = 74/146 (50%), Gaps = 2/146 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQG-GTGIS 330 KY K+G G+ G +Y +V T +EVAIK N++ + + L +++ + + I Sbjct: 269 KYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 328 Query: 331 NVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 N + GD +VM+ L G SL D+ + + + + + + +EF+HS + Sbjct: 329 NYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCRECLQALEFLHSNQVI 386 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFG 585 HRDIK DN L+G+ V + DFG Sbjct: 387 HRDIKSDNILLGMD---GSVKLTDFG 409
>PAK1_RAT (P35465) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) Length = 544 Score = 60.1 bits (144), Expect = 5e-09 Identities = 44/146 (30%), Positives = 74/146 (50%), Gaps = 2/146 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQG-GTGIS 330 KY K+G G+ G +Y +V T +EVAIK N++ + + L +++ + + I Sbjct: 268 KYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 327 Query: 331 NVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 N + GD +VM+ L G SL D+ + + + + + + +EF+HS + Sbjct: 328 NYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCRECLQALEFLHSNQVI 385 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFG 585 HRDIK DN L+G+ V + DFG Sbjct: 386 HRDIKSDNILLGMD---GSVKLTDFG 408
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 60.1 bits (144), Expect = 5e-09 Identities = 48/170 (28%), Positives = 83/170 (48%), Gaps = 13/170 (7%) Frame = +1 Query: 166 GRKLGSGSFGEIYLGTNVQTNEEVAIKLENV---KTKHPQLLYESKLYR----VLQGGTG 324 G +G GSFG +YL NV T E +A+K V +++ +L + R L+ Sbjct: 1178 GEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDH 1237 Query: 325 ISNVKWFGVEGD---YNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHS 495 ++ V++ G E Y++ + V G S+ L R + L Q++ + ++HS Sbjct: 1238 LNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGR-FDEPLIKHLTTQVLKGLAYLHS 1296 Query: 496 KSFLHRDIKPDNFLM---GLGKRANQVYMIDFGLAKKYRDTSTHQHIPYR 636 K LHRD+K DN L+ G+ K + DFG+++K +D ++ + R Sbjct: 1297 KGILHRDMKADNLLLDQDGICK------ISDFGISRKSKDIYSNSDMTMR 1340
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 60.1 bits (144), Expect = 5e-09 Identities = 53/184 (28%), Positives = 82/184 (44%), Gaps = 25/184 (13%) Frame = +1 Query: 130 PMEPRVGNKYRLGR-----KLGSGSFGEIYLGTNVQTNEEVAIKLENVKT---------- 264 P++P V R+GR LG GSFG++ L +V T ++VA+K+ N KT Sbjct: 38 PIDPNVNPANRIGRYQIIKTLGEGSFGKVKLAQHVGTGQKVALKIINRKTLAKSDMQGRV 97 Query: 265 ----------KHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFS 414 +HP ++ KLY V++ D ++V++ G L D + Sbjct: 98 EREISYLRLLRHPHII---KLYDVIK-------------SKDEIIMVIEFAGKELFD-YI 140 Query: 415 FCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAK 594 K+ Q+I VE+ H +HRD+KP+N L L + N V + DFGL+ Sbjct: 141 VQRGKMPEDEARRFFQQIIAAVEYCHRHKIVHRDLKPENLL--LDDQLN-VKIADFGLSN 197 Query: 595 KYRD 606 D Sbjct: 198 IMTD 201
>CSK2A_SCHPO (P40231) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II alpha| subunit) Length = 332 Score = 59.7 bits (143), Expect = 7e-09 Identities = 40/151 (26%), Positives = 78/151 (51%), Gaps = 1/151 (0%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGIS 330 + Y + RK+G G + E++ G NV N + IK+ K+ ++ E K+ + L GG I Sbjct: 41 DNYEIIRKVGRGKYSEVFEGLNVLNNSKCIIKVLK-PVKYKKIKREIKILQNLAGGPNI- 98 Query: 331 NVKWFGVEGDYNVLVMDVLGPSLEDL-FSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 + + D ++ ++++ F LS + + +++ ++F HS+ + Sbjct: 99 -ISLLDIVRDPESKTPSLIFEFVDNIDFRTLYPTLSDYDIRYYSYELLKALDFCHSRGIM 157 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 HRD+KP N ++ KR ++ +ID+GLA+ Y Sbjct: 158 HRDVKPHNVMIDHKKR--KLRLIDWGLAEFY 186
>PAK1_MOUSE (O88643) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) Length = 545 Score = 59.7 bits (143), Expect = 7e-09 Identities = 44/146 (30%), Positives = 74/146 (50%), Gaps = 2/146 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQG-GTGIS 330 KY K+G G+ G +Y +V T +EVAIK N++ + + L +++ + + I Sbjct: 269 KYTPFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 328 Query: 331 NVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 N + GD +VM+ L G SL D+ + + + + + + +EF+HS + Sbjct: 329 NYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCRECLQALEFLHSNQVI 386 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFG 585 HRDIK DN L+G+ V + DFG Sbjct: 387 HRDIKSDNILLGMD---GSVKLTDFG 409
>KPK2_PLAFK (Q02595) Probable serine/threonine-protein kinase 2 (EC 2.7.11.1)| Length = 510 Score = 59.7 bits (143), Expect = 7e-09 Identities = 45/157 (28%), Positives = 76/157 (48%), Gaps = 10/157 (6%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGI 327 N Y L +K+G GSF Y+GTN+ V +K ++ K K + E ++ R + I Sbjct: 109 NVYVLNKKIGKGSFSTAYIGTNILYGNRVVVKEVDKSKVKESNVYTEIEVLRKVMHKYII 168 Query: 328 SNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNR---------KLSLKTVLMLADQMINRV 480 + + EG + LV++ L +LF + N K ++K VL+ + Sbjct: 169 KLISAYEQEG-FVYLVLEYLKGG--ELFEYLNNNGPYTEQVAKKAMKRVLI-------AL 218 Query: 481 EFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 E +HS +HRD+K +N ++ + + +IDFGLA Sbjct: 219 EALHSNGVVHRDLKMENLMLENPNDPSSLKIIDFGLA 255
>BRSK1_HUMAN (Q8TDC3) BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1| kinase) (SAD1A) Length = 794 Score = 59.7 bits (143), Expect = 7e-09 Identities = 53/179 (29%), Positives = 83/179 (46%), Gaps = 3/179 (1%) Frame = +1 Query: 64 VPP*LDALNLGGGSVACVRARPPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAI 243 VP D + GGG R VG YRL + LG G G + LG + T ++VAI Sbjct: 20 VPERKDEVAGGGGEEEEAEERGRHAQYVG-PYRLEKTLGKGQTGLVKLGVHCITGQKVAI 78 Query: 244 KLEN-VKTKHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFC 420 K+ N K L+ + +L+ +K V + L + + S +LF + Sbjct: 79 KIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYL 138 Query: 421 NRK--LSLKTVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 +K L+ K Q+++ ++F HS S HRD+KP+N L+ N + + DFG+A Sbjct: 139 VKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLL---DEKNNIRIADFGMA 194
>TAOK3_HUMAN (Q9H2K8) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen H Length = 898 Score = 59.3 bits (142), Expect = 9e-09 Identities = 46/159 (28%), Positives = 70/159 (44%), Gaps = 5/159 (3%) Frame = +1 Query: 172 KLGSGSFGEIYLGTNVQTNEEVAIKL-----ENVKTKHPQLLYESKLYRVLQGGTGISNV 336 ++G GSFG +Y TN T+E VAIK + K +L E K R L+ I Sbjct: 29 EIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTI-EY 87 Query: 337 KWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 K ++ LVM+ S DL + L + + ++ + ++HS + +HRD Sbjct: 88 KGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRD 147 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 IK N L+ QV + DFG A ++ PY Sbjct: 148 IKAGNILL---TEPGQVKLADFGSASMASPANSFVGTPY 183
>CDK9B_XENLA (Q7ZX42) Cell division protein kinase 9-B (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9-B) Length = 376 Score = 59.3 bits (142), Expect = 9e-09 Identities = 47/165 (28%), Positives = 78/165 (47%), Gaps = 15/165 (9%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGG 318 +KY K+G G+FGE++ + QT ++VA+K +EN K P L E K+ ++L+ Sbjct: 17 SKYERLAKIGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 319 TGISNV-----KWFGVEGDYN------VLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQ 465 + + K YN LV D L L S + K ++ + + Sbjct: 77 NVVHLIEICRNKISPTANQYNRCKGTIFLVFDFCEHDLAGLLSNAHVKFTVAEIKKVMQM 136 Query: 466 MINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 ++N + +IH LHRD+K N L+ R + + DFGLA+ + Sbjct: 137 LLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAF 178
>CDPK1_ORYSA (P53682) Calcium-dependent protein kinase, isoform 1 (EC 2.7.11.1)| (CDPK 1) Length = 534 Score = 59.3 bits (142), Expect = 9e-09 Identities = 48/162 (29%), Positives = 76/162 (46%), Gaps = 7/162 (4%) Frame = +1 Query: 139 PRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL---ENVK--TKHPQLLYESKLYR 303 P V Y LGR+LG G FG+ YL T + T + A K N++ + + E ++ Sbjct: 67 PNVRELYTLGRELGQGQFGKTYLCTEISTGCQYACKTILKSNLRCVSDIEDVRREIQIMH 126 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRK--LSLKTVLMLADQMINR 477 L G I +K + +VM++ +LFS ++ S + L ++ Sbjct: 127 HLSGQKNIVTIKDTYEDEQAVHIVMELCAGG--ELFSKIQKRGHYSERKAAELIKIIVGI 184 Query: 478 VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYR 603 +E HS +HRD+KP+NFL+ V IDFGL+ +R Sbjct: 185 IETCHSHGVMHRDLKPENFLLLDADDEFSVKAIDFGLSVFFR 226
>CDK9_HUMAN (P50750) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4) Length = 372 Score = 59.3 bits (142), Expect = 9e-09 Identities = 46/161 (28%), Positives = 79/161 (49%), Gaps = 11/161 (6%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGG 318 +KY K+G G+FGE++ + +T ++VA+K +EN K P L E K+ ++L+ Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 319 TGISNVKWFGVEGD-YN------VLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINR 477 ++ ++ + YN LV D L L S K +L + + ++N Sbjct: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 Query: 478 VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 + +IH LHRD+K N L+ R + + DFGLA+ + Sbjct: 137 LYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAF 174
>PIM1_MOUSE (P06803) Proto-oncogene serine/threonine-protein kinase Pim-1 (EC| 2.7.11.1) Length = 397 Score = 59.3 bits (142), Expect = 9e-09 Identities = 53/178 (29%), Positives = 84/178 (47%), Gaps = 14/178 (7%) Frame = +1 Query: 118 RARPPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK------------LENVK 261 + + P+E ++Y++G LGSG FG +Y G V N VAIK L N Sbjct: 113 KEKEPLE----SQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGT 168 Query: 262 TKHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLK 441 +++ K+ G I + WF D VL+++ P ++DLF F + +L+ Sbjct: 169 RVPMEVVLLKKVSSDFSG--VIRLLDWF-ERPDSFVLILERPEP-VQDLFDFITERGALQ 224 Query: 442 TVLMLAD--QMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 L Q++ V H+ LHRDIK +N L+ L + ++ +IDFG +DT Sbjct: 225 EDLARGFFWQVLEAVRHCHNCGVLHRDIKDENILIDLSR--GEIKLIDFGSGALLKDT 280
>PIT1_SCHPO (O14132) Sporulation protein kinase pit1 (EC 2.7.11.1)| Length = 650 Score = 59.3 bits (142), Expect = 9e-09 Identities = 46/156 (29%), Positives = 82/156 (52%), Gaps = 9/156 (5%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRV-----LQGGT 321 Y + RK+G G+FG +YL T ++EV + ++++K K ++ ++L V L Sbjct: 36 YNVVRKVGDGTFGSVYLATTKTPSKEV-VAIKSMKKKLAKVSDATRLREVHSLLRLSENE 94 Query: 322 GISNVKWFGVEGDYNV-LVMDVLGPSLEDLFSFC-NRKLSLKTVLMLADQMINRVEFIHS 495 I N+ ++ + +VM+ L +L L S N L+L+ V + Q+ + IH+ Sbjct: 95 NIVNIFDLYIDQFRCLHIVMEFLDCNLYQLISTRKNDPLTLEQVQDIMRQIFKGLNHIHT 154 Query: 496 KSFLHRDIKPDNFLMGLGKRAN--QVYMIDFGLAKK 597 F HRD+KP+N L+ ++ V + DFGLA++ Sbjct: 155 NGFFHRDMKPENILISSNSDSSSFNVKIADFGLARE 190
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 59.3 bits (142), Expect = 9e-09 Identities = 49/167 (29%), Positives = 83/167 (49%), Gaps = 11/167 (6%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGG 318 R+G +Y LG LG G E+Y + + +VA+K L + P ++++ R Q Sbjct: 6 RLGGRYELGPVLGRGGMAEVYHAHDTRLGRQVAVKTLRADLARDPS--FQARFRREAQSA 63 Query: 319 TGISN---VKWFGVEGDY--NV----LVMD-VLGPSLEDLFSFCNRKLSLKTVLMLADQM 468 +++ V + DY NV +VM+ V G +L +L RKL + L + + Sbjct: 64 ASLNHPAIVAVYDTGEDYIDNVSIPYIVMEYVDGSTLRELL-HSGRKLLPERTLEMTIGI 122 Query: 469 INRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 + +E+ H +HRDIKP N ++ R QV ++DFG+A+ D+ Sbjct: 123 LQALEYSHRAGIVHRDIKPANVML---TRNGQVKVMDFGIARAMGDS 166
>TAOK3_RAT (Q53UA7) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory kinase) (Axotomy-related gene 357 protein) Length = 898 Score = 58.9 bits (141), Expect = 1e-08 Identities = 45/158 (28%), Positives = 70/158 (44%), Gaps = 4/158 (2%) Frame = +1 Query: 172 KLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYES--KLYRVLQGGTGISNVKWF 345 ++G GSFG +Y TN TNE VAIK + K ++ K R LQ + +++ Sbjct: 29 EIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDILKEVRFLQQLKHPNTIEYK 88 Query: 346 G--VEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRDI 519 G ++ LVM+ S DL + L + + + + ++H S +HRDI Sbjct: 89 GCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHFHSLIHRDI 148 Query: 520 KPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 K N L+ QV + DFG A ++ PY Sbjct: 149 KAGNILL---TEPGQVKLADFGSASMASPANSFVGTPY 183
>CDC7_YEAST (P06243) Cell division control protein 7 (EC 2.7.11.1)| Length = 507 Score = 58.9 bits (141), Expect = 1e-08 Identities = 49/170 (28%), Positives = 76/170 (44%), Gaps = 14/170 (8%) Frame = +1 Query: 139 PRVGNKYRLGRKLGSGSFGEIYLGTNVQT--------------NEEVAIKLENVKTKHPQ 276 P + N+Y+L K+G G+F +Y ++ + VA+K V T PQ Sbjct: 27 PGIENEYKLIDKIGEGTFSSVYKAKDITGKITKKFASHFWNYGSNYVALKKIYV-TSSPQ 85 Query: 277 LLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLML 456 +Y +L TG S V V+ VL + F R L +K + Sbjct: 86 RIYNE--LNLLYIMTGSSRVAPLCDAKRVRDQVIAVLPYYPHEEFRTFYRDLPIKGIKKY 143 Query: 457 ADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 +++ ++F+HSK +HRDIKP NFL L + ++DFGLA+ D Sbjct: 144 IWELLRALKFVHSKGIIHRDIKPTNFLFNL--ELGRGVLVDFGLAEAQMD 191
>CDK5_MOUSE (P49615) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6) Length = 292 Score = 58.9 bits (141), Expect = 1e-08 Identities = 43/159 (27%), Positives = 74/159 (46%), Gaps = 10/159 (6%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK----------LENVKTKHPQLLYESKLYR 303 KY K+G G++G ++ N +T+E VA+K + + + LL E K Sbjct: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVE 483 +++ + + K LV + L+ F CN L + V Q++ + Sbjct: 63 IVRLHDVLHSDKKL-------TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 F HS++ LHRD+KP N L+ R ++ + DFGLA+ + Sbjct: 116 FCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAF 151
>CDK5_HUMAN (Q00535) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 58.9 bits (141), Expect = 1e-08 Identities = 43/159 (27%), Positives = 74/159 (46%), Gaps = 10/159 (6%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK----------LENVKTKHPQLLYESKLYR 303 KY K+G G++G ++ N +T+E VA+K + + + LL E K Sbjct: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVE 483 +++ + + K LV + L+ F CN L + V Q++ + Sbjct: 63 IVRLHDVLHSDKKL-------TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 F HS++ LHRD+KP N L+ R ++ + DFGLA+ + Sbjct: 116 FCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAF 151
>CDK5_BOVIN (Q02399) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Proline-directed protein kinase 33 kDa subunit) (PDPK) Length = 292 Score = 58.9 bits (141), Expect = 1e-08 Identities = 43/159 (27%), Positives = 74/159 (46%), Gaps = 10/159 (6%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK----------LENVKTKHPQLLYESKLYR 303 KY K+G G++G ++ N +T+E VA+K + + + LL E K Sbjct: 3 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVE 483 +++ + + K LV + L+ F CN L + V Q++ + Sbjct: 63 IVRLHDVLHSDKKL-------TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 115 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 F HS++ LHRD+KP N L+ R ++ + DFGLA+ + Sbjct: 116 FCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAF 151
>CDK9_BOVIN (Q5EAB2) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 58.9 bits (141), Expect = 1e-08 Identities = 46/160 (28%), Positives = 78/160 (48%), Gaps = 11/160 (6%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGGT 321 KY K+G G+FGE++ + +T ++VA+K +EN K P L E K+ ++L+ Sbjct: 18 KYEKLAKIGQGTFGEVFKAKHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 Query: 322 GISNVKWFGVEGD-YN------VLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRV 480 ++ ++ + YN LV D L L S K +L + + ++N + Sbjct: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 Query: 481 EFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 +IH LHRD+K N L+ R + + DFGLA+ + Sbjct: 138 YYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAF 174
>CSK2A_DROME (P08181) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II alpha| subunit) Length = 335 Score = 58.9 bits (141), Expect = 1e-08 Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 9/157 (5%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y+L RKLG G + E++ N+ T E+ +K L+ VK K ++ E K+ L+GGT I Sbjct: 36 YQLVRKLGRGKYSEVFEAINITTTEKCVVKILKPVKKK--KIKREIKILENLRGGTNIIT 93 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------QMINRVEFI 489 + +V D + + +F N + L D +++ +++ Sbjct: 94 LL---------AVVKDPVSRTPALIFEHVNNTDFKQLYQTLTDYEIRYYLFELLKALDYC 144 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 HS +HRD+KP N ++ R ++ +ID+GLA+ Y Sbjct: 145 HSMGIMHRDVKPHNVMIDHENR--KLRLIDWGLAEFY 179
>MAK_RAT (P20793) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 622 Score = 58.5 bits (140), Expect = 2e-08 Identities = 46/155 (29%), Positives = 73/155 (47%), Gaps = 4/155 (2%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT---KHPQLLYESKLYRVLQGGT 321 N+Y R+LG G++G + +G + ++ E VAIK K L E K + L Sbjct: 2 NRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHAN 61 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 I +K E D+ + + + +L L N+ + + Q++ + FIH Sbjct: 62 VIK-LKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120 Query: 502 FLHRDIKPDNFL-MGLGKRANQVYMIDFGLAKKYR 603 F HRD+KP+N L MG V + DFGLA++ R Sbjct: 121 FFHRDMKPENLLCMG----PELVKIADFGLARELR 151
>PAK3_PONPY (Q7YQL3) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 58.5 bits (140), Expect = 2e-08 Identities = 42/146 (28%), Positives = 74/146 (50%), Gaps = 2/146 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQG-GTGIS 330 KY K+G G+ G +Y ++ T +EVAIK N++ + + L +++ + + I Sbjct: 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 341 Query: 331 NVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 N + GD +VM+ L G SL D+ + + + + + + ++F+HS + Sbjct: 342 NYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCRECLQALDFLHSNQVI 399 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFG 585 HRDIK DN L+G+ V + DFG Sbjct: 400 HRDIKSDNILLGMD---GSVKLTDFG 422
>PAK3_PANTR (Q7YQL4) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 58.5 bits (140), Expect = 2e-08 Identities = 42/146 (28%), Positives = 74/146 (50%), Gaps = 2/146 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQG-GTGIS 330 KY K+G G+ G +Y ++ T +EVAIK N++ + + L +++ + + I Sbjct: 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 341 Query: 331 NVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 N + GD +VM+ L G SL D+ + + + + + + ++F+HS + Sbjct: 342 NYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCRECLQALDFLHSNQVI 399 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFG 585 HRDIK DN L+G+ V + DFG Sbjct: 400 HRDIKSDNILLGMD---GSVKLTDFG 422
>PAK3_MOUSE (Q61036) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B) Length = 559 Score = 58.5 bits (140), Expect = 2e-08 Identities = 42/146 (28%), Positives = 74/146 (50%), Gaps = 2/146 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQG-GTGIS 330 KY K+G G+ G +Y ++ T +EVAIK N++ + + L +++ + + I Sbjct: 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 341 Query: 331 NVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 N + GD +VM+ L G SL D+ + + + + + + ++F+HS + Sbjct: 342 NYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCRECLQALDFLHSNQVI 399 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFG 585 HRDIK DN L+G+ V + DFG Sbjct: 400 HRDIKSDNILLGMD---GSVKLTDFG 422
>PAK3_HUMAN (O75914) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3) Length = 559 Score = 58.5 bits (140), Expect = 2e-08 Identities = 42/146 (28%), Positives = 74/146 (50%), Gaps = 2/146 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQG-GTGIS 330 KY K+G G+ G +Y ++ T +EVAIK N++ + + L +++ + + I Sbjct: 282 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 341 Query: 331 NVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 N + GD +VM+ L G SL D+ + + + + + + ++F+HS + Sbjct: 342 NYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCRECLQALDFLHSNQVI 399 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFG 585 HRDIK DN L+G+ V + DFG Sbjct: 400 HRDIKSDNILLGMD---GSVKLTDFG 422
>CDK5_XENLA (P51166) Cell division protein kinase 5 (EC 2.7.11.22) (Neuronal| cyclin-dependent kinase 5) Length = 292 Score = 58.5 bits (140), Expect = 2e-08 Identities = 43/159 (27%), Positives = 73/159 (45%), Gaps = 10/159 (6%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK----------LENVKTKHPQLLYESKLYR 303 KY K+G G++G ++ N T+E VA+K + + + LL E K Sbjct: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVE 483 +++ + + K LV + L+ F CN L + V Q++ + Sbjct: 63 IVRLHDVLHSDKKL-------TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLA 115 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 F HS++ LHRD+KP N L+ R ++ + DFGLA+ + Sbjct: 116 FCHSRNVLHRDLKPQNLLI---NRNGELKLADFGLARAF 151
>MAK_HUMAN (P20794) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 623 Score = 58.5 bits (140), Expect = 2e-08 Identities = 46/155 (29%), Positives = 73/155 (47%), Gaps = 4/155 (2%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT---KHPQLLYESKLYRVLQGGT 321 N+Y R+LG G++G + +G + ++ E VAIK K L E K + L Sbjct: 2 NRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHAN 61 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 I +K E D+ + + + +L L N+ + + Q++ + FIH Sbjct: 62 VIK-LKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120 Query: 502 FLHRDIKPDNFL-MGLGKRANQVYMIDFGLAKKYR 603 F HRD+KP+N L MG V + DFGLA++ R Sbjct: 121 FFHRDMKPENLLCMG----PELVKIADFGLARELR 151
>SNF1_YEAST (P06782) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 633 Score = 58.5 bits (140), Expect = 2e-08 Identities = 49/174 (28%), Positives = 81/174 (46%), Gaps = 20/174 (11%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT-------------------- 264 +GN Y++ + LG GSFG++ L + T ++VA+K+ N K Sbjct: 52 IGN-YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLL 110 Query: 265 KHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKT 444 +HP ++ KLY V++ I ++V++ G L D + K+S + Sbjct: 111 RHPHII---KLYDVIKSKDEI-------------IMVIEYAGNELFD-YIVQRDKMSEQE 153 Query: 445 VLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 Q+I+ VE+ H +HRD+KP+N L L + N V + DFGL+ D Sbjct: 154 ARRFFQQIISAVEYCHRHKIVHRDLKPENLL--LDEHLN-VKIADFGLSNIMTD 204
>PAK3_RAT (Q62829) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (p65-PAK) Length = 544 Score = 58.5 bits (140), Expect = 2e-08 Identities = 42/146 (28%), Positives = 74/146 (50%), Gaps = 2/146 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQG-GTGIS 330 KY K+G G+ G +Y ++ T +EVAIK N++ + + L +++ + + I Sbjct: 267 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 326 Query: 331 NVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 N + GD +VM+ L G SL D+ + + + + + + ++F+HS + Sbjct: 327 NYLDSYLVGDELWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCRECLQALDFLHSNQVI 384 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFG 585 HRDIK DN L+G+ V + DFG Sbjct: 385 HRDIKSDNILLGMD---GSVKLTDFG 407
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 58.5 bits (140), Expect = 2e-08 Identities = 50/164 (30%), Positives = 84/164 (51%), Gaps = 10/164 (6%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENV---KTKHPQLLYE-SKLYRVLQ 312 K+ G +GSGSFG++YLG N + E +A+K L++V K +H +LL + +LQ Sbjct: 393 KWIRGALIGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQ 452 Query: 313 GGTGISNVKWFG--VEGDY-NVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVE 483 + V++ G + D+ N+ + V G S+ L + V Q + +E Sbjct: 453 ELSHEHIVQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMYG-SFEETLVKNFIKQTLKGLE 511 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTST 615 ++HS+ +HRDIK N L+ ++ + DFG++KK ST Sbjct: 512 YLHSRGIVHRDIKGANILV---DNKGKIKISDFGISKKLELNST 552
>CDK4_XENLA (Q91727) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 319 Score = 58.2 bits (139), Expect = 2e-08 Identities = 48/168 (28%), Positives = 82/168 (48%), Gaps = 12/168 (7%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQL----LYESKLY 300 M + +Y ++G G++G +Y ++Q+ + VA+K V+T L + E L Sbjct: 1 MSKEMKGQYEPVAEIGVGAYGTVYKARDLQSGKFVALKNVRVQTNENGLPLSTVREVTLL 60 Query: 301 RVLQGGTGISNVKWFGV----EGDYNVLVMDVLGPSLEDLFSFCNRK----LSLKTVLML 456 + L+ + VK V D V V +DL ++ ++ L L+T+ L Sbjct: 61 KRLEHFDHPNIVKLMDVCASARTDRETKVTLVFEHVDQDLKTYLSKVPPPGLPLETIKDL 120 Query: 457 ADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 Q ++ +EF+H +HRD+KP+N L+ G QV + DFGLA+ Y Sbjct: 121 MKQFLSGLEFLHLNCIVHRDLKPENILVTSG---GQVKLADFGLARIY 165
>KIN10_ARATH (Q38997) SNF1-related protein kinase catalytic alpha subunit KIN10| (EC 2.7.11.1) (AKIN10) (AKIN alpha2) Length = 535 Score = 58.2 bits (139), Expect = 2e-08 Identities = 51/172 (29%), Positives = 76/172 (44%), Gaps = 22/172 (12%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT--------------------KHPQ 276 Y+LGR LG GSFG + + + T +VAIK+ N + HP Sbjct: 42 YKLGRTLGIGSFGRVKIAEHALTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPH 101 Query: 277 LLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRK--LSLKTVL 450 ++ +LY V++ T I LVM+ + +LF + K L Sbjct: 102 II---RLYEVIETPTDI-------------YLVMEYVNSG--ELFDYIVEKGRLQEDEAR 143 Query: 451 MLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 Q+I+ VE+ H +HRD+KP+N L L + N V + DFGL+ RD Sbjct: 144 NFFQQIISGVEYCHRNMVVHRDLKPENLL--LDSKCN-VKIADFGLSNIMRD 192
>PKNA_MYCTU (P65726) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 431 Score = 58.2 bits (139), Expect = 2e-08 Identities = 49/169 (28%), Positives = 83/169 (49%), Gaps = 15/169 (8%) Frame = +1 Query: 133 MEPRVG----NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKL 297 M PRVG +YRL R + +G G+++ + + VA+K L++ + P+ + + Sbjct: 1 MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRA 60 Query: 298 YR---VLQGGTGISNVKWFGV-----EGDYNVLVMDVLGPSLEDLFSFCNR--KLSLKTV 447 + GI++V +G EG LVM+++ E L S R +LSL+ Sbjct: 61 EARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNG--EPLNSVLKRTGRLSLRHA 118 Query: 448 LMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAK 594 L + +Q ++ H+ +HRD+KP N L+ QV + DFG+AK Sbjct: 119 LDMLEQTGRALQIAHAAGLVHRDVKPGNILI---TPTGQVKITDFGIAK 164
>PKNA_MYCBO (P65727) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 431 Score = 58.2 bits (139), Expect = 2e-08 Identities = 49/169 (28%), Positives = 83/169 (49%), Gaps = 15/169 (8%) Frame = +1 Query: 133 MEPRVG----NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKL 297 M PRVG +YRL R + +G G+++ + + VA+K L++ + P+ + + Sbjct: 1 MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRA 60 Query: 298 YR---VLQGGTGISNVKWFGV-----EGDYNVLVMDVLGPSLEDLFSFCNR--KLSLKTV 447 + GI++V +G EG LVM+++ E L S R +LSL+ Sbjct: 61 EARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNG--EPLNSVLKRTGRLSLRHA 118 Query: 448 LMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAK 594 L + +Q ++ H+ +HRD+KP N L+ QV + DFG+AK Sbjct: 119 LDMLEQTGRALQIAHAAGLVHRDVKPGNILI---TPTGQVKITDFGIAK 164
>YP62_CAEEL (Q09437) Putative serine/threonine-protein kinase B0495.2 (EC| 2.7.11.1) Length = 719 Score = 58.2 bits (139), Expect = 2e-08 Identities = 48/162 (29%), Positives = 80/162 (49%), Gaps = 10/162 (6%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHPQLLYESKLYRVLQGGT 321 ++Y ++ G+FG +Y G + +T+E VA+K +E K P + ++ +L+ G Sbjct: 354 DEYECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEGFP-ITALREINMLLKAGN 412 Query: 322 --GISNVK--WFGVEGDYNVLVMDVLG---PSLEDLFSFCNRKLSLKTVLMLADQMINRV 480 I NVK G D + M+ + SL D S N++ S+ L Q+++ + Sbjct: 413 HPNIVNVKEILLGSNMDKIYMAMEFVEHDMKSLLDTMSRRNKRFSIGEQKTLLQQLLSGI 472 Query: 481 EFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 E +H LHRD+K N LM + + DFGLA++Y D Sbjct: 473 EHMHKLWILHRDLKTSNLLM---SHKGILKIADFGLAREYGD 511
>TAOK1_RAT (O88664) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 58.2 bits (139), Expect = 2e-08 Identities = 44/159 (27%), Positives = 73/159 (45%), Gaps = 4/159 (2%) Frame = +1 Query: 169 RKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYES--KLYRVLQGGTGISNVKW 342 R++G GSFG +Y +V+TNE VAIK + K ++ K + LQ +++++ Sbjct: 32 REIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEY 91 Query: 343 FG--VEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 G + LVM+ S DL + L + + + + ++HS + +HRD Sbjct: 92 KGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRD 151 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 IK N L+ QV + DFG A ++ PY Sbjct: 152 IKAGNILL---TEPGQVKLADFGSASMASPANSFVGTPY 187
>TAOK1_MOUSE (Q5F2E8) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 58.2 bits (139), Expect = 2e-08 Identities = 44/159 (27%), Positives = 73/159 (45%), Gaps = 4/159 (2%) Frame = +1 Query: 169 RKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYES--KLYRVLQGGTGISNVKW 342 R++G GSFG +Y +V+TNE VAIK + K ++ K + LQ +++++ Sbjct: 32 REIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEY 91 Query: 343 FG--VEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 G + LVM+ S DL + L + + + + ++HS + +HRD Sbjct: 92 KGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRD 151 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 IK N L+ QV + DFG A ++ PY Sbjct: 152 IKAGNILL---TEPGQVKLADFGSASMASPANSFVGTPY 187
>TAOK1_HUMAN (Q7L7X3) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B) Length = 1001 Score = 58.2 bits (139), Expect = 2e-08 Identities = 44/159 (27%), Positives = 73/159 (45%), Gaps = 4/159 (2%) Frame = +1 Query: 169 RKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYES--KLYRVLQGGTGISNVKW 342 R++G GSFG +Y +V+TNE VAIK + K ++ K + LQ +++++ Sbjct: 32 REIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEY 91 Query: 343 FG--VEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 G + LVM+ S DL + L + + + + ++HS + +HRD Sbjct: 92 KGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRD 151 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 IK N L+ QV + DFG A ++ PY Sbjct: 152 IKAGNILL---TEPGQVKLADFGSASMASPANSFVGTPY 187
>PAK2_RAT (Q64303) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p62-PAK) Length = 524 Score = 58.2 bits (139), Expect = 2e-08 Identities = 44/146 (30%), Positives = 70/146 (47%), Gaps = 2/146 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENV-KTKHPQLLYESKLYRVLQGGTGIS 330 KY K+G G+ G ++ T+V +EVAIK N+ K +L+ L I Sbjct: 248 KYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIV 307 Query: 331 NVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 N + GD +VM+ L G SL D+ + + + + + + +EF+H+ + Sbjct: 308 NFLDSYLVGDELFVVMEYLAGGSLTDVVT--ETCMDEAQIAAVCRECLQALEFLHANQVI 365 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFG 585 HRDIK DN L+G+ V + DFG Sbjct: 366 HRDIKSDNVLLGM---EGSVKLTDFG 388
>PAK2_RABIT (Q29502) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p21-activated protein kinase I) (PAKI) Length = 524 Score = 58.2 bits (139), Expect = 2e-08 Identities = 44/146 (30%), Positives = 70/146 (47%), Gaps = 2/146 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENV-KTKHPQLLYESKLYRVLQGGTGIS 330 KY K+G G+ G ++ T+V +EVAIK N+ K +L+ L I Sbjct: 248 KYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIV 307 Query: 331 NVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 N + GD +VM+ L G SL D+ + + + + + + +EF+H+ + Sbjct: 308 NFLDSYLVGDELFVVMEYLAGGSLTDVVT--ETCMDEAQIAAVCRECLQALEFLHANQVI 365 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFG 585 HRDIK DN L+G+ V + DFG Sbjct: 366 HRDIKSDNVLLGM---EGSVKLTDFG 388
>PAK2_MOUSE (Q8CIN4) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) Length = 524 Score = 58.2 bits (139), Expect = 2e-08 Identities = 44/146 (30%), Positives = 70/146 (47%), Gaps = 2/146 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENV-KTKHPQLLYESKLYRVLQGGTGIS 330 KY K+G G+ G ++ T+V +EVAIK N+ K +L+ L I Sbjct: 248 KYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIV 307 Query: 331 NVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 N + GD +VM+ L G SL D+ + + + + + + +EF+H+ + Sbjct: 308 NFLDSYLVGDELFVVMEYLAGGSLTDVVT--ETCMDEAQIAAVCRECLQALEFLHANQVI 365 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFG 585 HRDIK DN L+G+ V + DFG Sbjct: 366 HRDIKSDNVLLGM---EGSVKLTDFG 388
>PAK2_HUMAN (Q13177) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 58.2 bits (139), Expect = 2e-08 Identities = 44/146 (30%), Positives = 70/146 (47%), Gaps = 2/146 (1%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENV-KTKHPQLLYESKLYRVLQGGTGIS 330 KY K+G G+ G ++ T+V +EVAIK N+ K +L+ L I Sbjct: 248 KYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIV 307 Query: 331 NVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 N + GD +VM+ L G SL D+ + + + + + + +EF+H+ + Sbjct: 308 NFLDSYLVGDELFVVMEYLAGGSLTDVVT--ETCMDEAQIAAVCRECLQALEFLHANQVI 365 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFG 585 HRDIK DN L+G+ V + DFG Sbjct: 366 HRDIKSDNVLLGM---EGSVKLTDFG 388
>KCC1_EMENI (Q00771) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CMPK) Length = 414 Score = 58.2 bits (139), Expect = 2e-08 Identities = 41/150 (27%), Positives = 73/150 (48%), Gaps = 4/150 (2%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL---ENVKTKHPQLLYESKLYRVLQGGTGI 327 YR GR LG+G++G + ++ +VA+K+ NV+ + E L + L + Sbjct: 23 YRFGRTLGAGTYGIVREADC--SSGKVAVKIILKRNVRGNERMVYDELDLLQKLNHPHIV 80 Query: 328 SNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNR-KLSLKTVLMLADQMINRVEFIHSKSF 504 V WF + + ++ G L D C K + K Q+++ V ++H ++ Sbjct: 81 HFVDWFESKDKFYIVTQLATGGELFD--RICEYGKFTEKDASQTIRQVLDAVNYLHQRNI 138 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAK 594 +HRD+KP+N L +Q+ + DFG+AK Sbjct: 139 VHRDLKPENLLYLTRDLDSQLVLADFGIAK 168
>CSK22_ARATH (Q08466) Casein kinase II subunit alpha-2 (EC 2.7.11.1) (CK II)| Length = 333 Score = 57.8 bits (138), Expect = 3e-08 Identities = 43/150 (28%), Positives = 76/150 (50%), Gaps = 2/150 (1%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y + RK+G G + E++ G N+ NE+ IK L+ VK K ++ E K+ + L GG I Sbjct: 34 YEVVRKVGRGKYSEVFEGINMNNNEKCIIKILKPVKKK--KIRREIKILQNLCGGPNI-- 89 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDL-FSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLH 510 VK V D + ++ + F L+ + +++ ++F HS+ +H Sbjct: 90 VKLLDVVRDQHSKTPSLIFEYVNSTDFKVLYPTLTDYDIRYYIYELLKALDFCHSQGIMH 149 Query: 511 RDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 RD+KP N + + ++ +ID+GLA+ Y Sbjct: 150 RDVKPHNVM--IDHELRKLRLIDWGLAEFY 177
>TAOK3_MOUSE (Q8BYC6) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 57.8 bits (138), Expect = 3e-08 Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 5/159 (3%) Frame = +1 Query: 172 KLGSGSFGEIYLGTNVQTNEEVAIKL-----ENVKTKHPQLLYESKLYRVLQGGTGISNV 336 ++G GSFG +Y TN TNE VA+K + K +L E K + L+ I Sbjct: 29 EIGHGSFGAVYFATNAHTNEVVAVKKMSYSGKQTHEKWQDILKEVKFLQQLKHPNTI-EY 87 Query: 337 KWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 K ++ LVM+ S DL + L + + + + ++H S +HRD Sbjct: 88 KGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHFHSLIHRD 147 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 IK N L+ QV + DFG A ++ PY Sbjct: 148 IKAGNILL---TEPGQVKLADFGSASMASPANSFVGTPY 183
>CCRK_HUMAN (Q8IZL9) Cell cycle-related kinase (EC 2.7.11.22)| (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) Length = 346 Score = 57.8 bits (138), Expect = 3e-08 Identities = 40/154 (25%), Positives = 75/154 (48%), Gaps = 4/154 (2%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGG 318 ++Y + ++G G+ G ++ +V+T E VA+K L ++ P Q L E K + ++ Sbjct: 2 DQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDN 61 Query: 319 TGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSK 498 + +K G VL + + L ++ R L+ V ++ V F H+ Sbjct: 62 QYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHAN 121 Query: 499 SFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 + +HRD+KP N L+ + Q+ + DFGLA+ + Sbjct: 122 NIVHRDLKPANLLI---SASGQLKIADFGLARVF 152
>MAK_MOUSE (Q04859) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) (Protein kinase RCK) Length = 622 Score = 57.8 bits (138), Expect = 3e-08 Identities = 46/155 (29%), Positives = 73/155 (47%), Gaps = 4/155 (2%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT---KHPQLLYESKLYRVLQGGT 321 N+Y ++LG G++G + +G + ++ E VAIK K L E K + L Sbjct: 2 NRYTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHAN 61 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 I +K E D+ V + + +L L N+ + + Q++ + FIH Sbjct: 62 VIK-LKEVIRENDHLYFVFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG 120 Query: 502 FLHRDIKPDNFL-MGLGKRANQVYMIDFGLAKKYR 603 F HRD+KP+N L MG V + DFGLA++ R Sbjct: 121 FFHRDMKPENLLCMG----PELVKIADFGLARELR 151
>PKNA_MYCLE (P54743) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 437 Score = 57.8 bits (138), Expect = 3e-08 Identities = 48/169 (28%), Positives = 82/169 (48%), Gaps = 15/169 (8%) Frame = +1 Query: 133 MEPRVG----NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKL 297 M PR+G +YRL R + +G G+++ + + VA+K L+ + P+ + + Sbjct: 1 MSPRIGVMLSGRYRLHRLIATGGMGQVWEAVDSRLGRRVAVKVLKGEFSSDPEFIERFRA 60 Query: 298 YR---VLQGGTGISNVKWFGV-----EGDYNVLVMDVLGPSLEDLFSFCNR--KLSLKTV 447 + GI++V +G EG LVM+++ E L S R +LSL+ Sbjct: 61 EARTTAMLNHPGIASVHDYGESHMDGEGRTAYLVMELVNG--EPLNSVLKRTGRLSLRHA 118 Query: 448 LMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAK 594 L + +Q ++ H+ +HRD+KP N L+ QV + DFG+AK Sbjct: 119 LDMLEQTGRALQIAHAAGLVHRDVKPGNILI---TPTGQVKITDFGIAK 164
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 57.8 bits (138), Expect = 3e-08 Identities = 43/166 (25%), Positives = 77/166 (46%), Gaps = 7/166 (4%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGT 321 R+ +Y++ R +G G +YL ++ + EVAIK+ + + R Q + Sbjct: 6 RISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRFDYANDNEFIR-RFRREAQSAS 64 Query: 322 GISN-----VKWFGVEGDYNVLVMD-VLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVE 483 + + + G E D +VM+ V G +L++ + N L K L + +Q+++ + Sbjct: 65 SLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYIT-ANGPLHPKEALNIMEQIVSAIA 123 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTS-TH 618 H +HRDIKP N L+ + + DFG+A T+ TH Sbjct: 124 HAHQNQIVHRDIKPHNILI---DHMGNIKVTDFGIATALSSTTITH 166
>KPCD2_HUMAN (Q9BZL6) Serine/threonine-protein kinase D2 (EC 2.7.11.13)| (nPKC-D2) Length = 878 Score = 57.8 bits (138), Expect = 3e-08 Identities = 45/146 (30%), Positives = 75/146 (51%), Gaps = 6/146 (4%) Frame = +1 Query: 175 LGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHP-----QLLYESKLYRVLQGGTGISNVK 339 LGSG FG +Y G + +T +VA+K+ + K + P QL E + + L+ GI N++ Sbjct: 557 LGSGQFGVVYGGKHRKTGRDVAVKVID-KLRFPTKQESQLRNEVAILQSLRH-PGIVNLE 614 Query: 340 WFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 + +VM+ L G LE + S +L + L Q++ + +H K+ +H D Sbjct: 615 CMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCD 674 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAK 594 +KP+N L+ QV + DFG A+ Sbjct: 675 LKPENVLLASADPFPQVKLCDFGFAR 700
>CSK2A_MAIZE (P28523) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| (CK2-alpha) Length = 332 Score = 57.8 bits (138), Expect = 3e-08 Identities = 42/150 (28%), Positives = 77/150 (51%), Gaps = 2/150 (1%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y + RK+G G + E++ G NV NE+ IK L+ VK K ++ E K+ + L GG I Sbjct: 34 YEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKK--KIKREIKILQNLCGGPNI-- 89 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDL-FSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLH 510 VK + D + ++ + + F L+ + +++ +++ HS+ +H Sbjct: 90 VKLLDIVRDQHSKTPSLIFEYVNNTDFKVLYPTLTDYDIRYYIYELLKALDYCHSQGIMH 149 Query: 511 RDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 RD+KP N + + ++ +ID+GLA+ Y Sbjct: 150 RDVKPHNVM--IDHELRKLRLIDWGLAEFY 177
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 57.8 bits (138), Expect = 3e-08 Identities = 43/154 (27%), Positives = 74/154 (48%), Gaps = 11/154 (7%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGI-SN 333 + +G+ LG G FG +YL +T VA+K T H L +SK+ + ++ I SN Sbjct: 89 FEIGKPLGKGKFGRVYLAKEKKTGFIVALK-----TLHKSELVQSKIEKQVRREIEIQSN 143 Query: 334 VKWFGVEGDYN--------VLVMDVLGPSLEDLFSFCNR--KLSLKTVLMLADQMINRVE 483 ++ + Y L+++ G +L+ R + S + QM N + Sbjct: 144 LRHKNILRLYGHFHDEKRIYLILEFAGRG--ELYQHLRRAKRFSEEVASKYIFQMANALS 201 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFG 585 ++H K +HRDIKP+N L+G+ ++ + DFG Sbjct: 202 YLHKKHVIHRDIKPENILLGID---GEIKLSDFG 232
>SID1_SCHPO (O14305) Serine/threonine-protein kinase sid1 (EC 2.7.11.1)| (STE20-like kinase sid1) Length = 471 Score = 57.8 bits (138), Expect = 3e-08 Identities = 42/167 (25%), Positives = 86/167 (51%), Gaps = 3/167 (1%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQ 312 M P N Y L RKLGSGSFG ++ + + +AIK +++T + + +L Sbjct: 1 MYPLNANSYTLLRKLGSGSFGVVWKARENVSGDIIAIKQIDLETGIDDITDIEQEVFMLS 60 Query: 313 GGTGISNVKWFG--VEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVE 483 + ++++G V+G ++M+ + G S+ L +L+ + + ++ +++ + Sbjct: 61 NCNSSNVIQYYGCFVDGYTLWILMEHMDGGSVSGLLKM--GRLNEQVISIILREVLYGLN 118 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQH 624 ++H ++ +HRDIK N L L V + DFG+A + + ++ +H Sbjct: 119 YLHGQNKIHRDIKAANIL--LSSSTGNVKLADFGVAAQLSNAASRRH 163
>CHK2_HUMAN (O96017) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1)| Length = 543 Score = 57.8 bits (138), Expect = 3e-08 Identities = 44/164 (26%), Positives = 80/164 (48%), Gaps = 10/164 (6%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL--------ENVKTKHPQLLYESKL--Y 300 ++Y + + LGSG+ GE+ L +T ++VAIK+ + + P L E+++ Sbjct: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277 Query: 301 RVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRV 480 + L I +F E Y VL + G + + N++L T + QM+ V Sbjct: 278 KKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVG--NKRLKEATCKLYFYQMLLAV 335 Query: 481 EFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTS 612 +++H +HRD+KP+N L+ + + + DFG +K +TS Sbjct: 336 QYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS 379
>SPKD_SYNY3 (P54735) Serine/threonine-protein kinase D (EC 2.7.11.1)| Length = 505 Score = 57.8 bits (138), Expect = 3e-08 Identities = 45/168 (26%), Positives = 83/168 (49%), Gaps = 13/168 (7%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLG--TNVQTNEEVAIKL-------ENVKTKHPQLLY 285 M +V ++Y + + LGSG FG+ +L T + + + V IK N T+ Q L+ Sbjct: 1 MNVQVLDRYEIVKSLGSGGFGDTFLAKDTQIPSQKLVVIKRLKPANANSNTSTELIQKLF 60 Query: 286 ESKLYRVLQGGTGISNV----KWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLM 453 E + + G S + +F + ++ ++ + G SL ++ + + KT+L Sbjct: 61 EKEASVLEDLGEHNSQIPKLYSYFSNDNEFYLVQEYIQGVSLNEIAPISSEQA--KTIL- 117 Query: 454 LADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKK 597 ++ +++IHSK +HRDIKP+N + L + +IDFG K+ Sbjct: 118 --SSLLTTLKYIHSKGIIHRDIKPENII--LRDSDHLPVLIDFGAVKE 161
>KCC2D_RAT (P15791) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 533 Score = 57.4 bits (137), Expect = 4e-08 Identities = 43/156 (27%), Positives = 73/156 (46%), Gaps = 6/156 (3%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT----KHPQLLYESKLYRVL 309 R ++Y+L +LG G+F + + T +E A K+ N K H +L E+++ R+L Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68 Query: 310 QGGTGISNVKWFGVEGDYNVLVMDVL--GPSLEDLFSFCNRKLSLKTVLMLADQMINRVE 483 + + EG ++ LV D++ G ED+ + S Q++ V Sbjct: 69 KHPNIVRLHDSISEEG-FHYLVFDLVTGGELFEDIVA--REYYSEADASHCIQQILESVN 125 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 H +HRD+KP+N L+ + V + DFGLA Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA 161
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 57.4 bits (137), Expect = 4e-08 Identities = 41/161 (25%), Positives = 81/161 (50%), Gaps = 6/161 (3%) Frame = +1 Query: 136 EPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHP----QLLYESKLYR 303 +P +GN YRL + +G G+F ++ L +V T EVA+K+ + +P +L E ++ + Sbjct: 54 QPHIGN-YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMK 112 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSF--CNRKLSLKTVLMLADQMINR 477 +L + VK F V L + + S ++F + + ++ K Q+++ Sbjct: 113 ILNHP---NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 169 Query: 478 VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 V++ H K +HRD+K +N L+ + + DFG + ++ Sbjct: 170 VQYCHQKCIVHRDLKAENLLLDADM---NIKIADFGFSNEF 207
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 57.4 bits (137), Expect = 4e-08 Identities = 41/161 (25%), Positives = 81/161 (50%), Gaps = 6/161 (3%) Frame = +1 Query: 136 EPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHP----QLLYESKLYR 303 +P +GN YRL + +G G+F ++ L +V T EVA+K+ + +P +L E ++ + Sbjct: 54 QPHIGN-YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMK 112 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSF--CNRKLSLKTVLMLADQMINR 477 +L + VK F V L + + S ++F + + ++ K Q+++ Sbjct: 113 ILNHP---NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 169 Query: 478 VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 V++ H K +HRD+K +N L+ + + DFG + ++ Sbjct: 170 VQYCHQKCIVHRDLKAENLLLDADM---NIKIADFGFSNEF 207
>BRSK2_HUMAN (Q8IWQ3) BR serine/threonine-protein kinase 2 (EC 2.7.11.1)| (Serine/threonine-protein kinase 29) (SAD1B) Length = 736 Score = 57.4 bits (137), Expect = 4e-08 Identities = 45/148 (30%), Positives = 73/148 (49%), Gaps = 3/148 (2%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLEN-VKTKHPQLLYESKLYRVLQGGTGISN 333 YRL + LG G G + LG + T ++VAIK+ N K L+ + +L+ Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 78 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRK--LSLKTVLMLADQMINRVEFIHSKSFL 507 +K V + L + + S +LF + +K L+ K Q+I+ ++F HS S Sbjct: 79 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSIC 138 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFGLA 591 HRD+KP+N L+ N + + DFG+A Sbjct: 139 HRDLKPENLLL---DEKNNIRIADFGMA 163
>CSK22_XENLA (P28020) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 392 Score = 57.4 bits (137), Expect = 4e-08 Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 9/157 (5%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y+L RKLG G + E++ N+ NE+V +K L+ VK K ++ E K+ L+GG I Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNIIT 96 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------QMINRVEFI 489 + +V D + + +F N + L D +++ +++ Sbjct: 97 LA---------DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYC 147 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 HS +HRD+KP N ++ R ++ +ID+GLA+ Y Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFY 182
>CSK21_RAT (P19139) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| Length = 391 Score = 57.4 bits (137), Expect = 4e-08 Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 9/157 (5%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y+L RKLG G + E++ N+ NE+V +K L+ VK K ++ E K+ L+GG I Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNIIT 96 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------QMINRVEFI 489 + +V D + + +F N + L D +++ +++ Sbjct: 97 LA---------DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYC 147 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 HS +HRD+KP N ++ R ++ +ID+GLA+ Y Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFY 182
>CSK21_MOUSE (Q60737) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| Length = 391 Score = 57.4 bits (137), Expect = 4e-08 Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 9/157 (5%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y+L RKLG G + E++ N+ NE+V +K L+ VK K ++ E K+ L+GG I Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNIIT 96 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------QMINRVEFI 489 + +V D + + +F N + L D +++ +++ Sbjct: 97 LA---------DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYC 147 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 HS +HRD+KP N ++ R ++ +ID+GLA+ Y Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFY 182
>CSK21_HUMAN (P68400) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| Length = 391 Score = 57.4 bits (137), Expect = 4e-08 Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 9/157 (5%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y+L RKLG G + E++ N+ NE+V +K L+ VK K ++ E K+ L+GG I Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNIIT 96 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------QMINRVEFI 489 + +V D + + +F N + L D +++ +++ Sbjct: 97 LA---------DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYC 147 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 HS +HRD+KP N ++ R ++ +ID+GLA+ Y Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFY 182
>CSK21_CHICK (P21868) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| Length = 391 Score = 57.4 bits (137), Expect = 4e-08 Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 9/157 (5%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y+L RKLG G + E++ N+ NE+V +K L+ VK K ++ E K+ L+GG I Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNIIT 96 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------QMINRVEFI 489 + +V D + + +F N + L D +++ +++ Sbjct: 97 LA---------DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYC 147 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 HS +HRD+KP N ++ R ++ +ID+GLA+ Y Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFY 182
>CSK21_BOVIN (P68399) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II)| Length = 391 Score = 57.4 bits (137), Expect = 4e-08 Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 9/157 (5%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y+L RKLG G + E++ N+ NE+V +K L+ VK K ++ E K+ L+GG I Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK--KIKREIKILENLRGGPNIIT 96 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLAD--------QMINRVEFI 489 + +V D + + +F N + L D +++ +++ Sbjct: 97 LA---------DIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYC 147 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 HS +HRD+KP N ++ R ++ +ID+GLA+ Y Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHR--KLRLIDWGLAEFY 182
>CSK21_ARATH (Q08467) Casein kinase II subunit alpha-1 (EC 2.7.11.1) (CK II)| Length = 333 Score = 57.0 bits (136), Expect = 5e-08 Identities = 43/150 (28%), Positives = 76/150 (50%), Gaps = 2/150 (1%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y + RK+G G + E++ G NV + E+ IK L+ VK K ++ E K+ + L GG I Sbjct: 34 YEVVRKVGRGKYSEVFEGINVNSKEKCIIKILKPVKKK--KIRREIKILQNLCGGPNI-- 89 Query: 334 VKWFGVEGDYNVLVMDVLGPSLEDL-FSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLH 510 VK V D + ++ + F L+ + +++ ++F HS+ +H Sbjct: 90 VKLLDVVRDQHSKTPSLIFEYVNSTDFKVLYPTLTDYDIRYYIYELLKALDFCHSQGIMH 149 Query: 511 RDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 RD+KP N + + ++ +ID+GLA+ Y Sbjct: 150 RDVKPHNVM--IDHELRKLRLIDWGLAEFY 177
>KPCD3_HUMAN (O94806) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) (Protein kinase EPK2) Length = 890 Score = 57.0 bits (136), Expect = 5e-08 Identities = 45/146 (30%), Positives = 75/146 (51%), Gaps = 6/146 (4%) Frame = +1 Query: 175 LGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHP-----QLLYESKLYRVLQGGTGISNVK 339 LGSG FG +Y G + +T +VAIK+ + K + P QL E + + L GI N++ Sbjct: 582 LGSGQFGIVYGGKHRKTGRDVAIKVID-KMRFPTKQESQLRNEVAILQNLHH-PGIVNLE 639 Query: 340 WFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 + +VM+ L G LE + S +L + + Q++ + +H K+ +H D Sbjct: 640 CMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCD 699 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAK 594 +KP+N L+ + QV + DFG A+ Sbjct: 700 LKPENVLLASAEPFPQVKLCDFGFAR 725
>DUN1_YEAST (P39009) DNA damage response protein kinase DUN1 (EC 2.7.11.1)| Length = 513 Score = 57.0 bits (136), Expect = 5e-08 Identities = 44/173 (25%), Positives = 85/173 (49%), Gaps = 25/173 (14%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT-----KHPQLLYESKLYRVLQG 315 +KY LG++LG+G + + N +T ++VA+K+ + + K+ Q E+ + +Q Sbjct: 198 DKYLLGKELGAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQH 257 Query: 316 GTGISNVKWFGVEGDYNVLVMDVLGPSLED--LFSFCNRKLSLKT--VLMLADQMINRVE 483 ++ + F + + ++ ++D LF RK L+ L Q++ ++ Sbjct: 258 PNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGLK 317 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRAN----------------QVYMIDFGLAK 594 ++H ++ +HRDIKP+N L+ + +R N QV + DFGLAK Sbjct: 318 YLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAK 370
>KPCD3_MOUSE (Q8K1Y2) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) Length = 889 Score = 57.0 bits (136), Expect = 5e-08 Identities = 45/146 (30%), Positives = 75/146 (51%), Gaps = 6/146 (4%) Frame = +1 Query: 175 LGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHP-----QLLYESKLYRVLQGGTGISNVK 339 LGSG FG +Y G + +T +VAIK+ + K + P QL E + + L GI N++ Sbjct: 581 LGSGQFGIVYGGKHRKTGRDVAIKVID-KMRFPTKQESQLRNEVAILQNLHH-PGIVNLE 638 Query: 340 WFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 + +VM+ L G LE + S +L + + Q++ + +H K+ +H D Sbjct: 639 CMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCD 698 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAK 594 +KP+N L+ + QV + DFG A+ Sbjct: 699 LKPENVLLASAEPFPQVKLCDFGFAR 724
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 57.0 bits (136), Expect = 5e-08 Identities = 51/184 (27%), Positives = 81/184 (44%), Gaps = 25/184 (13%) Frame = +1 Query: 130 PMEPRVGNKYRLGR-----KLGSGSFGEIYLGTNVQTNEEVAIKLENVKT---------- 264 P++P R+GR LG GSFG++ L ++ T ++VA+K+ N KT Sbjct: 39 PIDPAANPANRIGRYQILKTLGEGSFGKVKLAQHLGTGQKVALKIINRKTLAKSDMQGRV 98 Query: 265 ----------KHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFS 414 +HP ++ KLY V++ D ++V++ G L D + Sbjct: 99 EREISYLRLLRHPHII---KLYDVIK-------------SKDEIIMVIEFAGKELFD-YI 141 Query: 415 FCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAK 594 K+ Q+I VE+ H +HRD+KP+N L L + N V + DFGL+ Sbjct: 142 VQRGKMPEDEARRFFQQIIAAVEYCHRHKIVHRDLKPENLL--LDDQLN-VKIADFGLSN 198 Query: 595 KYRD 606 D Sbjct: 199 IMTD 202
>CC2H1_TRYCO (P54664) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 57.0 bits (136), Expect = 5e-08 Identities = 41/156 (26%), Positives = 76/156 (48%), Gaps = 4/156 (2%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQ 312 +G++Y+ K+G GS+G +Y ++ T+ VA+K LE+V+ P + E + + L+ Sbjct: 1 MGSRYQRLEKIGEGSYGVVYRARDITTDVIVALKRIRLESVEEGVPCTAIREISILKELR 60 Query: 313 GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIH 492 + + E N LV + + L+ + L T+ ++ V F H Sbjct: 61 HENIVRLLDVCHSENRLN-LVFEYMEMDLKKYMDRASGNLDPATIQEFMRSLLKGVRFCH 119 Query: 493 SKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 ++ LHRD+KP N L+ R ++ + DFGL + + Sbjct: 120 ERNVLHRDLKPPNLLI---SREKELKLADFGLGRAF 152
>MARK3_MOUSE (Q03141) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (MPK-10) (ELKL motif kinase 2) Length = 753 Score = 56.6 bits (135), Expect = 6e-08 Identities = 41/161 (25%), Positives = 81/161 (50%), Gaps = 6/161 (3%) Frame = +1 Query: 136 EPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHP----QLLYESKLYR 303 +P +GN YRL + +G G+F ++ L ++ T EVAIK+ + +P +L E ++ + Sbjct: 50 QPHIGN-YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMK 108 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSF--CNRKLSLKTVLMLADQMINR 477 +L + VK F V L + + S ++F + + ++ K Q+++ Sbjct: 109 ILNHP---NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 165 Query: 478 VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 V++ H K +HRD+K +N L+ + + DFG + ++ Sbjct: 166 VQYCHQKRIVHRDLKAENLLLDADM---NIKIADFGFSNEF 203
>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.11.1)| (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2) Length = 487 Score = 56.6 bits (135), Expect = 6e-08 Identities = 41/149 (27%), Positives = 73/149 (48%), Gaps = 3/149 (2%) Frame = +1 Query: 172 KLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISNVKWFG- 348 KLG GS+G +Y + +T + VAIK V++ +++ E ++Q VK++G Sbjct: 35 KLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEIS---IMQQCDSPHVVKYYGS 91 Query: 349 -VEGDYNVLVMDVLGP-SLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRDIK 522 + +VM+ G S+ D+ N+ L+ + + + +E++H +HRDIK Sbjct: 92 YFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIK 151 Query: 523 PDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 N L+ A + DFG+A + DT Sbjct: 152 AGNILLNTEGHAK---LADFGVAGQLTDT 177
>MARK3_RAT (Q8VHF0) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| Length = 797 Score = 56.6 bits (135), Expect = 6e-08 Identities = 41/161 (25%), Positives = 81/161 (50%), Gaps = 6/161 (3%) Frame = +1 Query: 136 EPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHP----QLLYESKLYR 303 +P +GN YRL + +G G+F ++ L ++ T EVAIK+ + +P +L E ++ + Sbjct: 50 QPHIGN-YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMK 108 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSF--CNRKLSLKTVLMLADQMINR 477 +L + VK F V L + + S ++F + + ++ K Q+++ Sbjct: 109 ILNHP---NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 165 Query: 478 VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 V++ H K +HRD+K +N L+ + + DFG + ++ Sbjct: 166 VQYCHQKRIVHRDLKAENLLLDADM---NIKITDFGFSNEF 203
>M3K2_MOUSE (Q61083) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 56.6 bits (135), Expect = 6e-08 Identities = 43/166 (25%), Positives = 72/166 (43%), Gaps = 9/166 (5%) Frame = +1 Query: 127 PPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKL--- 297 P PR +RLG+ LG G+FG +YL +V T E+A+K + P+ E Sbjct: 346 PSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALEC 405 Query: 298 -YRVLQGGTGISNVKWFGVEGDYNVLVMDVL-----GPSLEDLFSFCNRKLSLKTVLMLA 459 ++L+ V+++G D + + G S++D L+ Sbjct: 406 EIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMELSPGGSIKDQLK-AYGALTENVTRKYT 464 Query: 460 DQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKK 597 Q++ V ++HS +HRDIK N L + + DFG +K+ Sbjct: 465 RQILEGVHYLHSNMIVHRDIKGANILR---DSTGNIKLGDFGASKR 507
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 56.2 bits (134), Expect = 8e-08 Identities = 45/157 (28%), Positives = 76/157 (48%), Gaps = 4/157 (2%) Frame = +1 Query: 163 LGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISNVKW 342 +G+++GSGSFG +Y G + + +VA+K+ NV PQ L K + T N+ Sbjct: 85 VGQRIGSGSFGTVYKG---KWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILL 141 Query: 343 F---GVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHR 513 F + ++ G SL K + ++ +A Q ++++H+KS +HR Sbjct: 142 FMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHR 201 Query: 514 DIKPDNFLMGLGKRANQVYMIDFGLAK-KYRDTSTHQ 621 D+K +N + V + DFGLA K R + +HQ Sbjct: 202 DLKSNNIFL---HEDLTVKIGDFGLATVKSRWSGSHQ 235
>CCRK_RAT (Q4KM34) Cell cycle-related kinase (EC 2.7.11.22)| Length = 346 Score = 56.2 bits (134), Expect = 8e-08 Identities = 40/154 (25%), Positives = 75/154 (48%), Gaps = 4/154 (2%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGG 318 ++Y + ++G G+ G ++ +V+T E VA+K L ++ P Q L E K + ++ Sbjct: 2 DQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGIPNQALREIKALQEIEDS 61 Query: 319 TGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSK 498 + +K G VL + + L ++ R L+ V ++ V F H+ Sbjct: 62 QYVVQLKAVFPHGAGFVLAFEFMLSDLAEVVRHAQRPLAPAQVKSYLQMLLKGVAFCHAN 121 Query: 499 SFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 + +HRD+KP N L+ + Q+ + DFGLA+ + Sbjct: 122 NIVHRDLKPANLLI---SASGQLKIADFGLARVF 152
>CCRK_MOUSE (Q9JHU3) Cell cycle-related kinase (EC 2.7.11.22)| (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) Length = 346 Score = 56.2 bits (134), Expect = 8e-08 Identities = 40/154 (25%), Positives = 75/154 (48%), Gaps = 4/154 (2%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGG 318 ++Y + ++G G+ G ++ +V+T E VA+K L ++ P Q L E K + ++ Sbjct: 2 DQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGIPNQALREIKALQEIEDS 61 Query: 319 TGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSK 498 + +K G VL + + L ++ R L+ V ++ V F H+ Sbjct: 62 QYVVQLKAVFPHGAGFVLAFEFMLSDLAEVVRHAQRPLAPAQVKSYLQMLLKGVAFCHAN 121 Query: 499 SFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 + +HRD+KP N L+ + Q+ + DFGLA+ + Sbjct: 122 NIVHRDLKPANLLI---SASGQLKIADFGLARVF 152
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 56.2 bits (134), Expect = 8e-08 Identities = 45/157 (28%), Positives = 76/157 (48%), Gaps = 4/157 (2%) Frame = +1 Query: 163 LGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISNVKW 342 +G+++GSGSFG +Y G + + +VA+K+ NV PQ L K + T N+ Sbjct: 69 VGQRIGSGSFGTVYKG---KWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILL 125 Query: 343 F---GVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHR 513 F + ++ G SL K + ++ +A Q ++++H+KS +HR Sbjct: 126 FMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHR 185 Query: 514 DIKPDNFLMGLGKRANQVYMIDFGLAK-KYRDTSTHQ 621 D+K +N + V + DFGLA K R + +HQ Sbjct: 186 DLKSNNIFL---HEDLTVKIGDFGLATVKSRWSGSHQ 219
>TLK2_HUMAN (Q86UE8) Serine/threonine-protein kinase tousled-like 2 (EC| 2.7.11.1) (Tousled-like kinase 2) (PKU-alpha) Length = 772 Score = 56.2 bits (134), Expect = 8e-08 Identities = 38/169 (22%), Positives = 77/169 (45%), Gaps = 11/169 (6%) Frame = +1 Query: 139 PRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL---------ENVKTKHPQLLYES 291 P + ++Y L LG G F E+Y ++ VA+K+ E + H E Sbjct: 456 PTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREY 515 Query: 292 KLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMI 471 ++++ L + +F ++ D V++ + D + ++ +S K + Q++ Sbjct: 516 RIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIV 575 Query: 472 NRVEFIHS--KSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTS 612 N +++++ +H D+KP N L+ G ++ + DFGL+K D S Sbjct: 576 NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDS 624
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 56.2 bits (134), Expect = 8e-08 Identities = 45/157 (28%), Positives = 76/157 (48%), Gaps = 4/157 (2%) Frame = +1 Query: 163 LGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISNVKW 342 +G+++GSGSFG +Y G + + +VA+K+ NV PQ L K + T N+ Sbjct: 459 VGQRIGSGSFGTVYKG---KWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILL 515 Query: 343 F---GVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHR 513 F + ++ G SL K + ++ +A Q ++++H+KS +HR Sbjct: 516 FMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHR 575 Query: 514 DIKPDNFLMGLGKRANQVYMIDFGLAK-KYRDTSTHQ 621 D+K +N + V + DFGLA K R + +HQ Sbjct: 576 DLKSNNIFL---HEDLTVKIGDFGLATVKSRWSGSHQ 609
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 56.2 bits (134), Expect = 8e-08 Identities = 45/157 (28%), Positives = 76/157 (48%), Gaps = 4/157 (2%) Frame = +1 Query: 163 LGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISNVKW 342 +G+++GSGSFG +Y G + + +VA+K+ NV PQ L K + T N+ Sbjct: 499 VGQRIGSGSFGTVYKG---KWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILL 555 Query: 343 F---GVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHR 513 F + ++ G SL K + ++ +A Q ++++H+KS +HR Sbjct: 556 FMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHR 615 Query: 514 DIKPDNFLMGLGKRANQVYMIDFGLAK-KYRDTSTHQ 621 D+K +N + V + DFGLA K R + +HQ Sbjct: 616 DLKSNNIFL---HEDLTVKIGDFGLATVKSRWSGSHQ 649
>HUNK_PANTR (Q68UT7) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) Length = 714 Score = 56.2 bits (134), Expect = 8e-08 Identities = 46/158 (29%), Positives = 76/158 (48%), Gaps = 8/158 (5%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKH------PQLLYESKLYR 303 RVGN RKLG GSF ++ G +V T E+VAIK+ + K L E ++ + Sbjct: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVL--GPSLEDLFSFCNRKLSLKTVLMLADQMINR 477 +++ + E Y LVM++ G + ++ ++L Q+I+ Sbjct: 117 MIRHPNITQLLDILETENSY-YLVMELCPGGNLMHKIYE--KKRLEESEARRYIRQLISA 173 Query: 478 VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 VE +H +HRD+K +N L+ N + +IDFGL+ Sbjct: 174 VEHLHRAGVVHRDLKIENLLL---DEDNNIKLIDFGLS 208
>HUNK_HUMAN (P57058) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19) Length = 714 Score = 56.2 bits (134), Expect = 8e-08 Identities = 46/158 (29%), Positives = 76/158 (48%), Gaps = 8/158 (5%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKH------PQLLYESKLYR 303 RVGN RKLG GSF ++ G +V T E+VAIK+ + K L E ++ + Sbjct: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVL--GPSLEDLFSFCNRKLSLKTVLMLADQMINR 477 +++ + E Y LVM++ G + ++ ++L Q+I+ Sbjct: 117 MIRHPNITQLLDILETENSY-YLVMELCPGGNLMHKIYE--KKRLEESEARRYIRQLISA 173 Query: 478 VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 VE +H +HRD+K +N L+ N + +IDFGL+ Sbjct: 174 VEHLHRAGVVHRDLKIENLLL---DEDNNIKLIDFGLS 208
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 56.2 bits (134), Expect = 8e-08 Identities = 48/175 (27%), Positives = 84/175 (48%), Gaps = 12/175 (6%) Frame = +1 Query: 127 PPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK--------LENVKTK-HPQL 279 P E ++R G +G G+FG +Y+G N+ + E +AIK KT+ H + Sbjct: 58 PRKEEAPSIRWRKGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRE 117 Query: 280 LYESKLYRVLQGGTGISNVKWFGV--EGD-YNVLVMDVLGPSLEDLFSFCNRKLSLKTVL 450 L E ++L+ + + V++ G E D N+L+ V G S+ L ++ Sbjct: 118 LEEE--VQLLKNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFG-SFPEPVII 174 Query: 451 MLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTST 615 M Q++ +E++H+ +HRDIK N L+ + + DFG +KK + +T Sbjct: 175 MYTKQLLLGLEYLHNNGIMHRDIKGANILV---DNKGCIRLADFGASKKVVELAT 226
>CCRK_MACMU (Q5EDC3) Cell cycle-related kinase (EC 2.7.11.22)| (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) Length = 243 Score = 56.2 bits (134), Expect = 8e-08 Identities = 40/154 (25%), Positives = 74/154 (48%), Gaps = 4/154 (2%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGG 318 ++Y + ++G G+ G ++ +V+T E VA+K L ++ P Q L E K + + Sbjct: 2 DQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMGDN 61 Query: 319 TGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSK 498 + +K G VL + + L ++ R L+ V ++ V F H+ Sbjct: 62 QYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHAN 121 Query: 499 SFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 + +HRD+KP N L+ + Q+ + DFGLA+ + Sbjct: 122 NIVHRDLKPANLLI---SASGQLKIADFGLARVF 152
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 56.2 bits (134), Expect = 8e-08 Identities = 45/157 (28%), Positives = 76/157 (48%), Gaps = 4/157 (2%) Frame = +1 Query: 163 LGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISNVKW 342 +G+++GSGSFG +Y G + + +VA+K+ NV PQ L K + T N+ Sbjct: 499 VGQRIGSGSFGTVYKG---KWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILL 555 Query: 343 F---GVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHR 513 F + ++ G SL K + ++ +A Q ++++H+KS +HR Sbjct: 556 FMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHR 615 Query: 514 DIKPDNFLMGLGKRANQVYMIDFGLAK-KYRDTSTHQ 621 D+K +N + V + DFGLA K R + +HQ Sbjct: 616 DLKSNNIFL---HEDLTVKIGDFGLATVKSRWSGSHQ 649
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 56.2 bits (134), Expect = 8e-08 Identities = 45/157 (28%), Positives = 76/157 (48%), Gaps = 4/157 (2%) Frame = +1 Query: 163 LGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISNVKW 342 +G+++GSGSFG +Y G + + +VA+K+ NV PQ L K + T N+ Sbjct: 21 VGQRIGSGSFGTVYKG---KWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILL 77 Query: 343 F---GVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHR 513 F + ++ G SL K + ++ +A Q ++++H+KS +HR Sbjct: 78 FMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHR 137 Query: 514 DIKPDNFLMGLGKRANQVYMIDFGLAK-KYRDTSTHQ 621 D+K +N + V + DFGLA K R + +HQ Sbjct: 138 DLKSNNIFL---HEDLTVKIGDFGLATVKSRWSGSHQ 171
>TLK2_MOUSE (O55047) Serine/threonine-protein kinase tousled-like 2 (EC| 2.7.11.1) (Tousled-like kinase 2) Length = 718 Score = 56.2 bits (134), Expect = 8e-08 Identities = 38/169 (22%), Positives = 77/169 (45%), Gaps = 11/169 (6%) Frame = +1 Query: 139 PRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL---------ENVKTKHPQLLYES 291 P + ++Y L LG G F E+Y ++ VA+K+ E + H E Sbjct: 402 PTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREY 461 Query: 292 KLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMI 471 ++++ L + +F ++ D V++ + D + ++ +S K + Q++ Sbjct: 462 RIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIV 521 Query: 472 NRVEFIHS--KSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTS 612 N +++++ +H D+KP N L+ G ++ + DFGL+K D S Sbjct: 522 NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDS 570
>PIM3_HUMAN (Q86V86) Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1)| Length = 326 Score = 55.8 bits (133), Expect = 1e-07 Identities = 51/165 (30%), Positives = 78/165 (47%), Gaps = 14/165 (8%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQ--------LLYESKLYRVLQ 312 Y++G LGSG FG +Y G+ + VA+K VK + + + E L R + Sbjct: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVK-HVVKERVTEWGSLGGATVPLEVVLLRKVG 98 Query: 313 GGTGISNV----KWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVL--MLADQMIN 474 G V WF D +LV++ P+ +DLF F + +L L Q++ Sbjct: 99 AAGGARGVIRLLDWF-ERPDGFLLVLERPEPA-QDLFDFITERGALDEPLARRFFAQVLA 156 Query: 475 RVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 V HS +HRDIK +N L+ L R+ ++ +IDFG +DT Sbjct: 157 AVRHCHSCGVVHRDIKDENLLVDL--RSGELKLIDFGSGALLKDT 199
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 55.8 bits (133), Expect = 1e-07 Identities = 41/161 (25%), Positives = 81/161 (50%), Gaps = 6/161 (3%) Frame = +1 Query: 136 EPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHP----QLLYESKLYR 303 +P +GN YRL + +G G+F ++ L +V T EVA+K+ + +P +L E ++ + Sbjct: 54 QPHIGN-YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMK 112 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSF--CNRKLSLKTVLMLADQMINR 477 +L + VK F V L + + S ++F + + ++ K Q+++ Sbjct: 113 ILNHP---NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 169 Query: 478 VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 V++ H K +HRD+K +N L+ + + DFG + ++ Sbjct: 170 VQYCHQKYIVHRDLKAENLLL---DGDMNIKIADFGFSNEF 207
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 55.8 bits (133), Expect = 1e-07 Identities = 47/160 (29%), Positives = 80/160 (50%), Gaps = 5/160 (3%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGT 321 R+G+ Y LG LG G+FG++ +G + T +VA+K+ N + K L K+ R +Q Sbjct: 14 RIGH-YILGDTLGVGTFGKVKVGKHELTGHKVAVKILN-RQKIRSLDVVGKIRREIQNLK 71 Query: 322 GISN---VKWFGVEGDYNVLVMDVLGPSLEDLFSFC--NRKLSLKTVLMLADQMINRVEF 486 + +K + V + + M + S +LF + N +L K L Q+++ V++ Sbjct: 72 LFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 131 Query: 487 IHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 H +HRD+KP+N L+ A + DFGL+ D Sbjct: 132 CHRHMVVHRDLKPENVLLDAHMNAK---IADFGLSNMMSD 168
>CHK2_MOUSE (Q9Z265) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1)| Length = 546 Score = 55.8 bits (133), Expect = 1e-07 Identities = 42/164 (25%), Positives = 78/164 (47%), Gaps = 10/164 (6%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT----------KHPQLLYESKLY 300 ++Y + + LGSG+ GE+ + +T ++VAIK+ + + P + E ++ Sbjct: 222 DEYIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSREADTAPSVETEIEIL 281 Query: 301 RVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRV 480 + L I F E Y VL + G + + N++L T + QM+ V Sbjct: 282 KKLNHPCIIKIKDVFDAEDYYIVLELMEGGELFDRVVG--NKRLKEATCKLYFYQMLVAV 339 Query: 481 EFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTS 612 +++H +HRD+KP+N L+ + + + DFG +K +TS Sbjct: 340 QYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGETS 383
>HUNK_MOUSE (O88866) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Length = 714 Score = 55.8 bits (133), Expect = 1e-07 Identities = 46/158 (29%), Positives = 76/158 (48%), Gaps = 8/158 (5%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKH------PQLLYESKLYR 303 RVGN RKLG GSF ++ G +V T E+VAIK+ + K L E ++ + Sbjct: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116 Query: 304 VLQGGTGISNVKWFGVEGDYNVLVMDVL--GPSLEDLFSFCNRKLSLKTVLMLADQMINR 477 +++ + E Y LVM++ G + ++ ++L Q+I+ Sbjct: 117 MIRHPNITQLLDILETENSY-YLVMELCPGGNLMHKIYE--KKRLDEAEARRYIRQLISA 173 Query: 478 VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 VE +H +HRD+K +N L+ N + +IDFGL+ Sbjct: 174 VEHLHRAGVVHRDLKIENLLL---DEDNNIKLIDFGLS 208
>MST4_MOUSE (Q99JT2) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) Length = 416 Score = 55.8 bits (133), Expect = 1e-07 Identities = 45/168 (26%), Positives = 86/168 (51%), Gaps = 7/168 (4%) Frame = +1 Query: 127 PPMEPRVGNKYRLGRKL---GSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKL 297 P M+ + + L KL G GSFGE++ G + +T + VAIK+ +++ ++ + Sbjct: 11 PGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQE 70 Query: 298 YRVLQGGTGISNVKWFG--VEGDYNVLVMDVL--GPSLEDLFSFCNRKLSLKTVLMLADQ 465 VL K++G ++G ++M+ L G +L+ L + + + T+L + Sbjct: 71 ITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATML---KE 127 Query: 466 MINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 ++ ++++HS+ +HRDIK N L+ V + DFG+A + DT Sbjct: 128 ILKGLDYLHSEKKIHRDIKAANVLL---SEQGDVKLADFGVAGQLTDT 172
>MST4_HUMAN (Q9P289) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase) Length = 416 Score = 55.8 bits (133), Expect = 1e-07 Identities = 45/168 (26%), Positives = 86/168 (51%), Gaps = 7/168 (4%) Frame = +1 Query: 127 PPMEPRVGNKYRLGRKL---GSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKL 297 P M+ + + L KL G GSFGE++ G + +T + VAIK+ +++ ++ + Sbjct: 11 PGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQE 70 Query: 298 YRVLQGGTGISNVKWFG--VEGDYNVLVMDVL--GPSLEDLFSFCNRKLSLKTVLMLADQ 465 VL K++G ++G ++M+ L G +L+ L + + + T+L + Sbjct: 71 ITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATML---KE 127 Query: 466 MINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 ++ ++++HS+ +HRDIK N L+ V + DFG+A + DT Sbjct: 128 ILKGLDYLHSEKKIHRDIKAANVLL---SEQGDVKLADFGVAGQLTDT 172
>KPCD1_HUMAN (Q15139) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 912 Score = 55.8 bits (133), Expect = 1e-07 Identities = 45/146 (30%), Positives = 73/146 (50%), Gaps = 6/146 (4%) Frame = +1 Query: 175 LGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHP-----QLLYESKLYRVLQGGTGISNVK 339 LGSG FG +Y G + +T +VAIK+ + K + P QL E + + L G+ N++ Sbjct: 589 LGSGQFGIVYGGKHRKTGRDVAIKIID-KLRFPTKQESQLRNEVAILQNLHH-PGVVNLE 646 Query: 340 WFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 + +VM+ L G LE + S +L L Q++ + +H K+ +H D Sbjct: 647 CMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCD 706 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAK 594 +KP+N L+ QV + DFG A+ Sbjct: 707 LKPENVLLASADPFPQVKLCDFGFAR 732
>M3K2_HUMAN (Q9Y2U5) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 55.8 bits (133), Expect = 1e-07 Identities = 44/166 (26%), Positives = 73/166 (43%), Gaps = 9/166 (5%) Frame = +1 Query: 127 PPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKL--- 297 P PR +RLG+ LG G+FG +YL +V T E+A+K P+ E Sbjct: 346 PSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALEC 405 Query: 298 -YRVLQGGTGISNVKWFGV-----EGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLA 459 ++L+ V+++G E ++ + + G S++D L+ Sbjct: 406 EIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLK-AYGALTENVTRKYT 464 Query: 460 DQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKK 597 Q++ V ++HS +HRDIK N L V + DFG +K+ Sbjct: 465 RQILEGVHYLHSNMIVHRDIKGANILR---DSTGNVKLGDFGASKR 507
>KCC1_METAN (O14408) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| Length = 382 Score = 55.5 bits (132), Expect = 1e-07 Identities = 39/152 (25%), Positives = 71/152 (46%), Gaps = 4/152 (2%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL---ENVKTKHPQLLYESKLYRVLQGGT 321 +KY+ GR LG+G++G + + +VAIK+ +NVK + E + + L Sbjct: 21 SKYKFGRTLGAGTYGVVREADG--PSGKVAIKIILKKNVKGNEKMVYAELDMLQRLTHPH 78 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNR-KLSLKTVLMLADQMINRVEFIHSK 498 + V WF + ++ G L D C++ K + Q++ V+++H Sbjct: 79 IVKFVDWFESRDKFYIVTQLATGGELFD--RICDQGKFTEVDASQTIRQIMTAVDYLHDN 136 Query: 499 SFLHRDIKPDNFLMGLGKRANQVYMIDFGLAK 594 +HRD+KP+N L + + + DFG+ K Sbjct: 137 DVVHRDLKPENLLYVTRDPDSDLVLADFGITK 168
>RIPK5_BRARE (Q4VSN1) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 885 Score = 55.5 bits (132), Expect = 1e-07 Identities = 44/153 (28%), Positives = 73/153 (47%), Gaps = 6/153 (3%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKH-PQLLYESKLYRVLQGGTGI 327 K +LGR+LG G +G +YL + A+K + KH L E R L + Sbjct: 613 KPKLGRELGRGQYGVVYLCDSWAGRHPCALKSVVPPDDKHWNDLALEFHYTRSLPKHERL 672 Query: 328 SNVKWFGVEGDYN----VLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHS 495 N+ ++ Y+ + V+ ++ DL++ LSLK L++A ++ + F+HS Sbjct: 673 VNLHGSVIDHSYSGGSSIAVLLIMERLHRDLYTGLKAGLSLKERLLIALDVVEGIRFLHS 732 Query: 496 KSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAK 594 + LHRDIK N L+ + N+ + D G K Sbjct: 733 QGLLHRDIKLKNVLL---DKQNRAKITDLGFCK 762
>CDC2H_DICDI (P34117) CDC2-like serine/threonine-protein kinase CRP (EC| 2.7.11.22) (EC 2.7.11.23) Length = 292 Score = 55.5 bits (132), Expect = 1e-07 Identities = 42/153 (27%), Positives = 69/153 (45%), Gaps = 4/153 (2%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQL----LYESKLYRVLQGGT 321 KY KLG G++G + N +T E VA+K + ++ + + E L + L+ Sbjct: 3 KYSKIEKLGEGTYGIVNKAKNRETGEIVALKRIRLDSEDEGVPCTAIREISLLKELKHPN 62 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 + E LV + L L+ C ++S T+ Q++ V F H Sbjct: 63 IVRLHDVIHTERKLT-LVFEYLDQDLKKYLDECGGEISKPTIKSFMYQLLKGVAFCHDHR 121 Query: 502 FLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 LHRD+KP N L+ R ++ + DFGLA+ + Sbjct: 122 VLHRDLKPQNLLI---NRKGELKLADFGLARAF 151
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 55.5 bits (132), Expect = 1e-07 Identities = 43/177 (24%), Positives = 82/177 (46%), Gaps = 10/177 (5%) Frame = +1 Query: 115 VRARPPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK----------LENVKT 264 V+ +PP+ ++R G+ +G G+FG +Y+G N+ + E +A+K E + Sbjct: 60 VQIKPPI------RWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQA 113 Query: 265 KHPQLLYESKLYRVLQGGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKT 444 +L E KL + L + + + N+L+ V G S+ L Sbjct: 114 HIQELEEEVKLLKNLSHPNIVRYLGTVREDETLNILLEFVPGGSISSLLEKFG-AFPESV 172 Query: 445 VLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTST 615 V +Q++ +E++H+ + +HRDIK N L+ + + DFG +K+ + +T Sbjct: 173 VRTYTNQLLLGLEYLHNHAIMHRDIKGANILV---DNQGCIKLADFGASKQVAELAT 226
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 55.1 bits (131), Expect = 2e-07 Identities = 44/150 (29%), Positives = 74/150 (49%), Gaps = 1/150 (0%) Frame = +1 Query: 160 RLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQ-LLYESKLYRVLQGGTGISNV 336 +L ++LG+G FGE+++GT N +VAIK T P+ L E+++ + L+ + Sbjct: 271 QLIKRLGNGQFGEVWMGT-WNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY 329 Query: 337 KWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 E Y V G L+ L R L L ++ +A Q+ + +I +++HRD Sbjct: 330 AVVSEEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVARGMAYIERMNYIHRD 389 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 ++ N L+G G + DFGLA+ D Sbjct: 390 LRSANILVGNGLICK---IADFGLARLIED 416
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 55.1 bits (131), Expect = 2e-07 Identities = 43/165 (26%), Positives = 78/165 (47%), Gaps = 5/165 (3%) Frame = +1 Query: 145 VGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLL---YESKLYRVLQ- 312 +GN+Y L + +G G +Y + N VA+K+ + K+ + + ++ + + Sbjct: 6 LGNRYELLQCVGEGGMSFVYKARCRKLNRFVAVKILKDEFKNNEEIVRRFKKEATAIANL 65 Query: 313 GGTGISNVKWFGVEGDYNVLVMD-VLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFI 489 + NV G + D N +VM+ V G +L+D+ L + + + ++ +E Sbjct: 66 SNPNVVNVLDVGTQDDINYIVMEYVEGKTLKDIIKE-KGALPYEVAISIGIKVAKALECA 124 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQH 624 H +HRD+KP N L+ V + DFG+AK D+ST H Sbjct: 125 HKSGIIHRDVKPQNILV---TEEGVVKVTDFGIAKS-MDSSTIAH 165
>PKNA_ANASP (P54734) Serine/threonine-protein kinase pknA (EC 2.7.11.1)| Length = 564 Score = 55.1 bits (131), Expect = 2e-07 Identities = 53/177 (29%), Positives = 84/177 (47%), Gaps = 18/177 (10%) Frame = +1 Query: 133 MEPRVGNKYRLGRKLGSGSFGEIYLGTNVQ--TNEEVAIKLENVKTKHPQL--LYESKLY 300 ME + N+YR+ + LGSG FGE +L + Q +N +K +PQ+ L + + Sbjct: 1 MEQLLDNRYRVIKTLGSGGFGETFLAEDSQMPSNRRCVVKQLRPIHNNPQIYQLVQERFQ 60 Query: 301 R---VLQ-----GGTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVL-- 450 R +L+ G + +F + V+ V G +L KL + VL Sbjct: 61 REAAILEDLGSYSGQIPTLYAYFQSNTQFYVVQEWVEGDTL-------TAKLKQQGVLSE 113 Query: 451 -MLADQMINR---VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 + D +IN +E++HSK +HRDIKPDN + L R + +IDFG ++ T Sbjct: 114 SAVRDILINLLPVLEYVHSKRIIHRDIKPDNII--LRHRDGKPVLIDFGAVRESMGT 168
>MYLK_DICDI (P25323) Myosin light chain kinase (EC 2.7.11.18) (MLCK)| Length = 295 Score = 55.1 bits (131), Expect = 2e-07 Identities = 41/150 (27%), Positives = 69/150 (46%), Gaps = 4/150 (2%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENV----KTKHPQLLYESKLYRVLQGGTG 324 Y +LG G+F +YLG N QT + AIK+ N K L E + + + Sbjct: 8 YEFKEELGRGAFSIVYLGENKQTKQRYAIKVINKSELGKDYEKNLKMEVDILKKVNHPNI 67 Query: 325 ISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSF 504 I+ + F +++ V G L D S L ++++ V ++H + Sbjct: 68 IALKELFDTPEKLYLVMELVTGGELFDKIVE-KGSYSEADAANLVKKIVSAVGYLHGLNI 126 Query: 505 LHRDIKPDNFLMGLGKRANQVYMIDFGLAK 594 +HRD+KP+N L+ + +V + DFGL+K Sbjct: 127 VHRDLKPENLLLKSKENHLEVAIADFGLSK 156
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 55.1 bits (131), Expect = 2e-07 Identities = 51/171 (29%), Positives = 81/171 (47%), Gaps = 17/171 (9%) Frame = +1 Query: 133 MEPRVGN-----KYRLGRK--LGSGSFGEIYLGTNVQTNE-EVAIKLENVKTKHPQLLYE 288 MEP G K+ RK +G G+F ++ G + + ++ EVA+K N K Sbjct: 1 MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL 60 Query: 289 SKLYRVLQGGTGISNVKWFGVEGDYN--VLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLA 459 K ++L+ + V + + N LVM+ G L D + R LS T+ + Sbjct: 61 GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLAD-YLHAMRTLSEDTIRLFL 119 Query: 460 DQMINRVEFIHSKSFLHRDIKPDNFLMG--LGKRAN----QVYMIDFGLAK 594 Q+ + +HSK +HRD+KP N L+ G+RAN +V + DFG A+ Sbjct: 120 QQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFAR 170
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 55.1 bits (131), Expect = 2e-07 Identities = 45/171 (26%), Positives = 78/171 (45%), Gaps = 19/171 (11%) Frame = +1 Query: 136 EPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL---------------ENVKTKH 270 E ++G Y RKLGSG++GE+ L + E AIK+ +N++ H Sbjct: 49 EGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYNDDNKNIEKFH 108 Query: 271 PQLLYESKLYRVLQGGTGISNVKWFGVEGD--YNVLVMDVL--GPSLEDLFSFCNRKLSL 438 ++ E L + L + +K F V D Y LV + G E + + K Sbjct: 109 EEIYNEISLLKSLDHP---NIIKLFDVFEDKKYFYLVTEFYEGGELFEQIIN--RHKFDE 163 Query: 439 KTVLMLADQMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 + Q+++ + ++H + +HRDIKP+N L+ + ++DFGL+ Sbjct: 164 CDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLS 214
>CSK2A_NEUCR (Q8TG13) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II alpha| subunit) Length = 336 Score = 55.1 bits (131), Expect = 2e-07 Identities = 45/161 (27%), Positives = 78/161 (48%), Gaps = 13/161 (8%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIK-LENVKTKHPQLLYESKLYRVLQGGTGISN 333 Y + RK+G G + E++ G NV ++ IK L+ VK K ++ E K+ + L GG I Sbjct: 32 YEVVRKIGRGKYSEVFEGINVVNYQKCVIKVLKPVKKK--KIKREIKILQNLAGGPNI-- 87 Query: 334 VKWFGVEGDYNVLVMDVLGPSLED----LFSFCNR--------KLSLKTVLMLADQMINR 477 V ++DV+ S +F + N + + V +++ Sbjct: 88 -----------VALLDVVRDSQSKTPSLIFEYVNNTEFRTLYPRFNDFDVRYYIFELLKA 136 Query: 478 VEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 ++F HSK +HRD+KP N ++ R ++ +ID+GLA+ Y Sbjct: 137 LDFCHSKGIMHRDVKPHNVMIDHENR--KLRLIDWGLAEFY 175
>CHK1_XENLA (Q6DE87) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (xChk1| protein) Length = 474 Score = 55.1 bits (131), Expect = 2e-07 Identities = 42/151 (27%), Positives = 75/151 (49%), Gaps = 4/151 (2%) Frame = +1 Query: 163 LGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKH--PQLLYESKLYRVLQGGTGISNV 336 L + LG G++GE+ L N +T E VA+K+ ++ P+ + + + T I V Sbjct: 11 LVQTLGEGAYGEVQLAVNRKTEEAVAVKIVDMTRAADCPENIKKEICINRMLSHTNI--V 68 Query: 337 KWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSL--KTVLMLADQMINRVEFIHSKSFLH 510 +++G + N+ + + +LF + + + Q+I VE++HS H Sbjct: 69 RFYGHRREGNIQYLFLEYCRGGELFDRIEPDVGMPEQDAQKFFQQLIAGVEYLHSIGITH 128 Query: 511 RDIKPDNFLMGLGKRANQVYMIDFGLAKKYR 603 RDIKP+N L+ +Q+ + DFGLA +R Sbjct: 129 RDIKPENLLL---DERDQLKISDFGLATVFR 156
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 55.1 bits (131), Expect = 2e-07 Identities = 44/156 (28%), Positives = 77/156 (49%), Gaps = 9/156 (5%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISNV 336 Y L +G+G F ++ L ++ T E VAIK+ + T S L R+ + N+ Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNT------LGSDLPRIKTEIEALKNL 64 Query: 337 KWFGVEGDYNVL-----VMDVL----GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFI 489 + + Y+VL + VL G L D + +LS + ++ Q+++ V ++ Sbjct: 65 RHQHICQLYHVLETANKIFMVLEYCPGGELFD-YIISQDRLSEEETRVVFRQIVSAVAYV 123 Query: 490 HSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKK 597 HS+ + HRD+KP+N L +++ +IDFGL K Sbjct: 124 HSQGYAHRDLKPENLLF---DEYHKLKLIDFGLCAK 156
>TAOK3_CHICK (Q9I9E0) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Kinase from chicken) Length = 898 Score = 54.7 bits (130), Expect = 2e-07 Identities = 43/159 (27%), Positives = 68/159 (42%), Gaps = 5/159 (3%) Frame = +1 Query: 172 KLGSGSFGEIYLGTNVQTNEEVAIKL-----ENVKTKHPQLLYESKLYRVLQGGTGISNV 336 ++G GSFG +Y TN TNE VA+K + K ++ E K + L+ I Sbjct: 29 EIGHGSFGAVYFATNSHTNEVVAVKKMSYSGKQTNEKWQDIIKEVKFLQQLKHPNTI-EY 87 Query: 337 KWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRD 516 K ++ LVM+ S D+ + L + + + + ++HS +HRD Sbjct: 88 KGCYLKEHTAWLVMEYCLGSASDMLEVHKKPLQEVEIAAITHGALQGLAYLHSHCKIHRD 147 Query: 517 IKPDNFLMGLGKRANQVYMIDFGLAKKYRDTSTHQHIPY 633 IK N L+ QV + DFG A ++ PY Sbjct: 148 IKAGNILL---TEPGQVKLADFGSASIVSPANSFVGTPY 183
>CCRK_PONPY (Q5R7I7) Cell cycle-related kinase (EC 2.7.11.22)| Length = 346 Score = 54.7 bits (130), Expect = 2e-07 Identities = 39/154 (25%), Positives = 74/154 (48%), Gaps = 4/154 (2%) Frame = +1 Query: 151 NKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIK---LENVKTKHP-QLLYESKLYRVLQGG 318 ++Y + ++G G+ G ++ +V+T E VA+K L ++ P Q L E K + ++ Sbjct: 2 DQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGIPNQALREIKALQEMEDN 61 Query: 319 TGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSK 498 + +K VL + + L ++ R L+ V ++ V F H+ Sbjct: 62 QYVVQLKAVFPHSAGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVSFCHAN 121 Query: 499 SFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKY 600 + +HRD+KP N L+ + Q+ + DFGLA+ + Sbjct: 122 NIVHRDLKPANLLI---SASGQLKIADFGLARVF 152
>PIM3_RAT (O70444) Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1)| (Protein kinase Kid-1) (Kinase induced by depolarization) Length = 326 Score = 54.7 bits (130), Expect = 2e-07 Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 14/165 (8%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQ--------LLYESKLYRVLQ 312 Y++G LGSG FG +Y G+ + VA+K VK + + + E L R + Sbjct: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVK-HVVKERVTEWGSLGGMAVPLEVVLLRKVG 98 Query: 313 GGTGISNV----KWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVL--MLADQMIN 474 G V WF D +LV++ P+ +DLF F + +L L Q++ Sbjct: 99 AAGGARGVIRLLDWF-ERPDGFLLVLERPEPA-QDLFDFITERGALDEPLARRFFAQVLA 156 Query: 475 RVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 V H+ +HRDIK +N L+ L R+ ++ +IDFG +DT Sbjct: 157 AVRHCHNCGVVHRDIKDENLLVDL--RSGELKLIDFGSGAVLKDT 199
>PIM3_MOUSE (P58750) Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1)| Length = 326 Score = 54.7 bits (130), Expect = 2e-07 Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 14/165 (8%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQ--------LLYESKLYRVLQ 312 Y++G LGSG FG +Y G+ + VA+K VK + + + E L R + Sbjct: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVK-HVVKERVTEWGSLGGVAVPLEVVLLRKVG 98 Query: 313 GGTGISNV----KWFGVEGDYNVLVMDVLGPSLEDLFSFCNRKLSLKTVL--MLADQMIN 474 G V WF D +LV++ P+ +DLF F + +L L Q++ Sbjct: 99 AAGGARGVIRLLDWF-ERPDGFLLVLERPEPA-QDLFDFITERGALDEPLARRFFAQVLA 156 Query: 475 RVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 V H+ +HRDIK +N L+ L R+ ++ +IDFG +DT Sbjct: 157 AVRHCHNCGVVHRDIKDENLLVDL--RSGELKLIDFGSGAVLKDT 199
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 54.7 bits (130), Expect = 2e-07 Identities = 45/155 (29%), Positives = 76/155 (49%), Gaps = 5/155 (3%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISN- 333 Y LG LG G+FG++ +G + T +VA+K+ N + K L K+ R +Q + Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILN-RQKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 334 --VKWFGVEGDYNVLVMDVLGPSLEDLFSFC--NRKLSLKTVLMLADQMINRVEFIHSKS 501 +K + V + + M + S +LF + N +L K L Q+++ V++ H Sbjct: 75 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 134 Query: 502 FLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 +HRD+KP+N L+ A + DFGL+ D Sbjct: 135 VVHRDLKPENVLLDAHMNAK---IADFGLSNMMSD 166
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 54.7 bits (130), Expect = 2e-07 Identities = 45/155 (29%), Positives = 76/155 (49%), Gaps = 5/155 (3%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISN- 333 Y LG LG G+FG++ +G + T +VA+K+ N + K L K+ R +Q + Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILN-RQKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 334 --VKWFGVEGDYNVLVMDVLGPSLEDLFSFC--NRKLSLKTVLMLADQMINRVEFIHSKS 501 +K + V + + M + S +LF + N +L K L Q+++ V++ H Sbjct: 75 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 134 Query: 502 FLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 +HRD+KP+N L+ A + DFGL+ D Sbjct: 135 VVHRDLKPENVLLDAHMNAK---IADFGLSNMMSD 166
>STK36_MOUSE (Q69ZM6) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1268 Score = 54.7 bits (130), Expect = 2e-07 Identities = 46/157 (29%), Positives = 69/157 (43%), Gaps = 10/157 (6%) Frame = +1 Query: 154 KYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISN 333 KY + +G GSFG +Y G + + VA+K P+L K R LQ I Sbjct: 3 KYHVLEMIGEGSFGRVYKGRKKYSAQVVALKFI------PKLGRSEKELRNLQREIEIMR 56 Query: 334 VKWF--------GVEGDYNVLVMDVLGPSLEDLFSFC--NRKLSLKTVLMLADQMINRVE 483 W E D V+V+ +LF + KL V +A Q+++ + Sbjct: 57 GLWHPNIVHMLDSFETDKEVVVVTDYAEG--ELFQILEDDGKLPEDQVQAIAAQLVSALY 114 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAK 594 ++HS LHRD+KP N L+ G + + DFG A+ Sbjct: 115 YLHSHRILHRDMKPQNILLAKG---GGIKLCDFGFAR 148
>ROCK1_RABIT (O77819) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (cAMP-dependent protein kinase ROCK-I) (CePKA) (Corneal epithelial Rho-associated-Ser/Thr kinase 1) (HEB Length = 1354 Score = 54.7 bits (130), Expect = 2e-07 Identities = 39/152 (25%), Positives = 71/152 (46%), Gaps = 5/152 (3%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL----ENVKTKHPQLLYESKLYRVLQGGTG 324 Y + + +G G+FGE+ L + T + A+KL E +K +E + Sbjct: 76 YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW 135 Query: 325 ISNVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 + + + + Y +VM+ + G L +L S N + K +++ ++ IHS Sbjct: 136 VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS--NYDVPEKWARFYTAEVVLALDAIHSMG 193 Query: 502 FLHRDIKPDNFLMGLGKRANQVYMIDFGLAKK 597 F+HRD+KPDN L+ ++ + + DFG K Sbjct: 194 FIHRDVKPDNMLL---DKSGHLKLADFGTCMK 222
>ROCK1_MOUSE (P70335) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) Length = 1354 Score = 54.7 bits (130), Expect = 2e-07 Identities = 39/152 (25%), Positives = 71/152 (46%), Gaps = 5/152 (3%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL----ENVKTKHPQLLYESKLYRVLQGGTG 324 Y + + +G G+FGE+ L + T + A+KL E +K +E + Sbjct: 76 YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW 135 Query: 325 ISNVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 + + + + Y +VM+ + G L +L S N + K +++ ++ IHS Sbjct: 136 VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS--NYDVPEKWARFYTAEVVLALDAIHSMG 193 Query: 502 FLHRDIKPDNFLMGLGKRANQVYMIDFGLAKK 597 F+HRD+KPDN L+ ++ + + DFG K Sbjct: 194 FIHRDVKPDNMLL---DKSGHLKLADFGTCMK 222
>ROCK1_HUMAN (Q13464) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen) Length = 1354 Score = 54.7 bits (130), Expect = 2e-07 Identities = 39/152 (25%), Positives = 71/152 (46%), Gaps = 5/152 (3%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL----ENVKTKHPQLLYESKLYRVLQGGTG 324 Y + + +G G+FGE+ L + T + A+KL E +K +E + Sbjct: 76 YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW 135 Query: 325 ISNVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 + + + + Y +VM+ + G L +L S N + K +++ ++ IHS Sbjct: 136 VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS--NYDVPEKWARFYTAEVVLALDAIHSMG 193 Query: 502 FLHRDIKPDNFLMGLGKRANQVYMIDFGLAKK 597 F+HRD+KPDN L+ ++ + + DFG K Sbjct: 194 FIHRDVKPDNMLL---DKSGHLKLADFGTCMK 222
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 54.7 bits (130), Expect = 2e-07 Identities = 45/155 (29%), Positives = 76/155 (49%), Gaps = 5/155 (3%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISN- 333 Y LG LG G+FG++ +G + T +VA+K+ N + K L K+ R +Q + Sbjct: 18 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILN-RQKIRSLDVVGKIRREIQNLKLFRHP 76 Query: 334 --VKWFGVEGDYNVLVMDVLGPSLEDLFSFC--NRKLSLKTVLMLADQMINRVEFIHSKS 501 +K + V + + M + S +LF + N +L K L Q+++ V++ H Sbjct: 77 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 136 Query: 502 FLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRD 606 +HRD+KP+N L+ A + DFGL+ D Sbjct: 137 VVHRDLKPENVLLDAHMNAK---IADFGLSNMMSD 168
>M4K5_MOUSE (Q8BPM2) Mitogen-activated protein kinase kinase kinase kinase 5| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) Length = 847 Score = 54.7 bits (130), Expect = 2e-07 Identities = 41/154 (26%), Positives = 78/154 (50%), Gaps = 3/154 (1%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISNV 336 Y L +++GSG++G++Y NV T E A+K+ ++ L + +++ V + + V Sbjct: 20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKE-CKHCNIV 78 Query: 337 KWFG--VEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFL 507 +FG + + + M+ G SL+D++ LS + + + + + ++H+K + Sbjct: 79 AYFGSYLSREKLWICMEYCGGGSLQDIYHVTG-PLSEMQIAYVCRETLQGLAYLHTKGKM 137 Query: 508 HRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 HRDIK N L+ V + DFG+A K T Sbjct: 138 HRDIKGANILL---TDHGDVKLADFGVAAKITAT 168
>CDPK3_ORYSA (P53684) Calcium-dependent protein kinase, isoform 11 (EC 2.7.11.1)| (CDPK 11) Length = 542 Score = 54.7 bits (130), Expect = 2e-07 Identities = 46/152 (30%), Positives = 69/152 (45%), Gaps = 7/152 (4%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL---ENVKTKH--PQLLYESKLYRVLQGGT 321 Y +GRKLG G FG YL T + T E A K + TK + E ++ L G Sbjct: 79 YIIGRKLGQGQFGTTYLCTEINTGCEYACKTIPKRKLITKEDVEDVRREIQIMHHLSGHK 138 Query: 322 GISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNRK--LSLKTVLMLADQMINRVEFIHS 495 + +K +G +VM++ +LF K S + L +++ V HS Sbjct: 139 NVVAIKDVYEDGQAVHIVMELCAGG--ELFDRIQEKGHYSERKAAELIRIIVSIVAMCHS 196 Query: 496 KSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 +HRD+KP+NFL+ + IDFGL+ Sbjct: 197 LGVMHRDLKPENFLLLDKDDDLSIKAIDFGLS 228
>STK25_MOUSE (Q9Z2W1) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 54.7 bits (130), Expect = 2e-07 Identities = 42/149 (28%), Positives = 74/149 (49%), Gaps = 3/149 (2%) Frame = +1 Query: 172 KLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGGTGISNVKWFG- 348 ++G GSFGE+Y G + T E VAIK+ +++ ++ + VL ++FG Sbjct: 25 RIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGS 84 Query: 349 -VEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKSFLHRDIK 522 ++ ++M+ L G S DL L + + +++ ++++HS+ +HRDIK Sbjct: 85 YLKSTKLWIIMEYLGGGSALDLLK--PGPLEETYIATILREILKGLDYLHSERKIHRDIK 142 Query: 523 PDNFLMGLGKRANQVYMIDFGLAKKYRDT 609 N L+ V M DFG+A + DT Sbjct: 143 AANVLL---SEQGDVKMADFGVAGQLTDT 168
>ROCK1_RAT (Q63644) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (p150 RhoA-binding kinase ROK beta) (Liver regeneration-related protein LRRG199) Length = 1369 Score = 54.7 bits (130), Expect = 2e-07 Identities = 39/152 (25%), Positives = 71/152 (46%), Gaps = 5/152 (3%) Frame = +1 Query: 157 YRLGRKLGSGSFGEIYLGTNVQTNEEVAIKL----ENVKTKHPQLLYESKLYRVLQGGTG 324 Y + + +G G+FGE+ L + T + A+KL E +K +E + Sbjct: 76 YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW 135 Query: 325 ISNVKWFGVEGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQMINRVEFIHSKS 501 + + + + Y +VM+ + G L +L S N + K +++ ++ IHS Sbjct: 136 VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS--NYDVPEKWARFYTAEVVLALDAIHSMG 193 Query: 502 FLHRDIKPDNFLMGLGKRANQVYMIDFGLAKK 597 F+HRD+KPDN L+ ++ + + DFG K Sbjct: 194 FIHRDVKPDNMLL---DKSGHLKLADFGTCMK 222
>KCC2D_HUMAN (Q13557) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 499 Score = 54.7 bits (130), Expect = 2e-07 Identities = 42/156 (26%), Positives = 72/156 (46%), Gaps = 6/156 (3%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT----KHPQLLYESKLYRVL 309 R ++Y+L +LG G+F + + T + A K+ N K H +L E+++ R+L Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQGYAAKIINTKKLSARDHQKLEREARICRLL 68 Query: 310 QGGTGISNVKWFGVEGDYNVLVMDVL--GPSLEDLFSFCNRKLSLKTVLMLADQMINRVE 483 + + EG ++ LV D++ G ED+ + S Q++ V Sbjct: 69 KHPNIVRLHDSISEEG-FHYLVFDLVTGGELFEDIVA--REYYSEADASHCIQQILESVN 125 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 H +HRD+KP+N L+ + V + DFGLA Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA 161
>KAPCG_HUMAN (P22612) cAMP-dependent protein kinase, gamma-catalytic subunit (EC| 2.7.11.11) (PKA C-gamma) Length = 350 Score = 54.7 bits (130), Expect = 2e-07 Identities = 45/167 (26%), Positives = 80/167 (47%), Gaps = 8/167 (4%) Frame = +1 Query: 127 PPMEPRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLEN----VKTKHPQLLYESK 294 P +++ R LG GSFG + L + +T A+K+ N VK K + + K Sbjct: 33 PAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEK 92 Query: 295 LYRVLQG--GTGISNVKWFGVEGDYNVLVMDVLGPSLEDLFSFCNR--KLSLKTVLMLAD 462 R+LQ + +++ + Y LVM+ + ++FS R + S A Sbjct: 93 --RILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGG--EMFSRLQRVGRFSEPHACFYAA 148 Query: 463 QMINRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYR 603 Q++ V+++HS +HRD+KP+N L+ + + + DFG AK+ + Sbjct: 149 QVVLAVQYLHSLDLIHRDLKPENLLI---DQQGYLQVTDFGFAKRVK 192
>KCC2G_RAT (P11730) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 527 Score = 54.3 bits (129), Expect = 3e-07 Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 6/156 (3%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT----KHPQLLYESKLYRVL 309 R + Y+L +LG G+F + + +E A K+ N K H +L E+++ R+L Sbjct: 9 RFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLL 68 Query: 310 QGGTGISNVKWFGVEGDYNVLVMDVL--GPSLEDLFSFCNRKLSLKTVLMLADQMINRVE 483 + + EG ++ LV D++ G ED+ + S Q++ V Sbjct: 69 KHPNIVRLHDSISEEG-FHYLVFDLVTGGELFEDIVA--REYYSEADASHCIHQILESVN 125 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 IH +HRD+KP+N L+ + V + DFGLA Sbjct: 126 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA 161
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 54.3 bits (129), Expect = 3e-07 Identities = 39/169 (23%), Positives = 76/169 (44%), Gaps = 10/169 (5%) Frame = +1 Query: 139 PRVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKTKHPQLLYESKLYRVLQGG 318 P + ++Y LG LG G E++L +++ + +VA+K+ Y + R Q Sbjct: 5 PHLSDRYELGDILGFGGMSEVHLARDIRLHRDVAVKVLRADLARDPSFY-LRFRREAQNA 63 Query: 319 TGISNVKWFGV---------EGDYNVLVMDVL-GPSLEDLFSFCNRKLSLKTVLMLADQM 468 +++ V G +VM+ + G +L D+ + + ++AD Sbjct: 64 AALNHPSIVAVYDTGEAETSAGPLPYIVMEYVDGATLRDIVHTDGPMPPQQAIEIVADAC 123 Query: 469 INRVEFIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLAKKYRDTST 615 + F H +HRD+KP N ++ N V ++DFG+A+ D+++ Sbjct: 124 -QALNFSHQNGIIHRDVKPANIMI---SATNAVKVMDFGIARAIADSTS 168
>KCC2G_MOUSE (Q923T9) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 529 Score = 54.3 bits (129), Expect = 3e-07 Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 6/156 (3%) Frame = +1 Query: 142 RVGNKYRLGRKLGSGSFGEIYLGTNVQTNEEVAIKLENVKT----KHPQLLYESKLYRVL 309 R + Y+L +LG G+F + + +E A K+ N K H +L E+++ R+L Sbjct: 9 RFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLL 68 Query: 310 QGGTGISNVKWFGVEGDYNVLVMDVL--GPSLEDLFSFCNRKLSLKTVLMLADQMINRVE 483 + + EG ++ LV D++ G ED+ + S Q++ V Sbjct: 69 KHPNIVRLHDSISEEG-FHYLVFDLVTGGELFEDIVA--REYYSEADASHCIHQILESVN 125 Query: 484 FIHSKSFLHRDIKPDNFLMGLGKRANQVYMIDFGLA 591 IH +HRD+KP+N L+ + V + DFGLA Sbjct: 126 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA 161 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 84,901,378 Number of Sequences: 219361 Number of extensions: 1610225 Number of successful extensions: 7951 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6474 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6963 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5995743495 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
