>EXT2_MOUSE (P70428) Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225)|
           (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-
           acetylglucosaminyl-proteoglycan
           4-alpha-N-acetylglucosaminyltransferase) (Multiple
           exostoses protein 2 homolog)
          Length = 718

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 32/105 (30%), Positives = 57/105 (54%)
 Frame = -1

Query: 582 TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
           +++LTGAAF    F +  Y  +     +++V  + NCED+ MNF+ AN    TG+  ++ 
Sbjct: 591 SMVLTGAAFYHKYFNYL-YTYKMPGDIKNWVDAHMNCEDIAMNFLVANV---TGKAVIK- 645

Query: 402 VHPAWAIDTSKLSSVAISRDTQKHYDVRTKCLAKFSSIYGPLPQK 268
           V P       + +++      Q H   R++C+ KF+S++G +P K
Sbjct: 646 VTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLK 690

>EXT2_HUMAN (Q93063) Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225)|
           (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-
           acetylglucosaminyl-proteoglycan
           4-alpha-N-acetylglucosaminyltransferase) (Putative tumor
           suppressor protein EXT2) (Multiple exostoses protein
          Length = 718

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 32/105 (30%), Positives = 57/105 (54%)
 Frame = -1

Query: 582 TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
           +++LTGAAF    F +  Y  +     +++V  + NCED+ MNF+ AN    TG+  ++ 
Sbjct: 591 SMVLTGAAFYHKYFNYL-YTYKMPGDIKNWVDAHMNCEDIAMNFLVANV---TGKAVIK- 645

Query: 402 VHPAWAIDTSKLSSVAISRDTQKHYDVRTKCLAKFSSIYGPLPQK 268
           V P       + +++      Q H   R++C+ KF+S++G +P K
Sbjct: 646 VTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLK 690

>EXT2_BOVIN (O77783) Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225)|
           (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-
           acetylglucosaminyl-proteoglycan
           4-alpha-N-acetylglucosaminyltransferase) (HS-polymerase)
           (HS-POL) (Multiple exostoses protein 2 homolog)
          Length = 718

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 32/105 (30%), Positives = 57/105 (54%)
 Frame = -1

Query: 582 TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
           +++LTGAAF    F +  Y  +     +++V  + NCED+ MNF+ AN    TG+  ++ 
Sbjct: 591 SMVLTGAAFYHKYFNYL-YTYKMPGDIKNWVDAHMNCEDIAMNFLVANV---TGKAVIK- 645

Query: 402 VHPAWAIDTSKLSSVAISRDTQKHYDVRTKCLAKFSSIYGPLPQK 268
           V P       + +++      Q H   R++C+ KF+S++G +P K
Sbjct: 646 VTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLK 690

>EXT2_DROME (Q9Y169) Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Protein sister|
           of tout-velu)
          Length = 717

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 33/108 (30%), Positives = 54/108 (50%), Gaps = 5/108 (4%)
 Frame = -1

Query: 582 TLILTGAAFMDSEFAFKRYWSEX---ARKG--RDYVHKNFNCEDLLMNFMYANASSGTGR 418
           +++LTGAAF        +YWS     A  G  +D+V ++ NCED+ MNF+ AN ++    
Sbjct: 590 SMVLTGAAF------HHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLVANITNNPPI 643

Query: 417 RTVEYVHPAWAIDTSKLSSVAISRDTQKHYDVRTKCLAKFSSIYGPLP 274
           +    V P       + ++  +      H   R+ C+ +FS IYG +P
Sbjct: 644 K----VTPRKKFKCPECTNTEMLSADLNHMRERSACIDRFSKIYGRMP 687

>EXT2_CAEEL (O01705) Exostosin-2 (EC 2.4.1.223) (EC 2.4.1.224)|
           (Glucuronyl-galactosyl-proteoglycan/Glucuronosyl-N-
           acetylglucosaminyl-proteoglycan
           4-alpha-N-acetylglucosaminyltransferase) (Multiple
           exostoses homolog 2)
          Length = 814

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 29/106 (27%), Positives = 52/106 (49%)
 Frame = -1

Query: 582 TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
           ++ILTGAAF+   +    Y  E   + R++V+   NCED+ MN++ ++ +     +T   
Sbjct: 691 SMILTGAAFIHKNY-LTAYTYEMPAEIREHVNSIKNCEDIAMNYLVSHLTRKPPIKTTS- 748

Query: 402 VHPAWAIDTSKLSSVAISRDTQKHYDVRTKCLAKFSSIYGPLPQKW 265
               W +     +       T  H++ R +C+  F+ IYG  P K+
Sbjct: 749 ---RWTLKCPTCTESLYKEGT--HFEKRHECMRLFTKIYGYNPLKF 789

>EXTL3_HUMAN (O43909) Exostosin-like 3 (EC 2.4.1.223)|
            (Glucuronyl-galactosyl-proteoglycan
            4-alpha-N-acetylglucosaminyltransferase) (Putative tumor
            suppressor protein EXTL3) (Multiple exostosis-like
            protein 3) (Hereditary multiple exostoses gene isolog) (E
          Length = 919

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 32/103 (31%), Positives = 50/103 (48%)
 Frame = -1

Query: 582  TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
            +++LTGAAF    +A+  Y     +  RD V +  NCED+ MNF+ ++ +    R+    
Sbjct: 796  SMVLTGAAFFHKYYAYL-YSYVMPQAIRDMVDEYINCEDIAMNFLVSHIT----RKPPIK 850

Query: 402  VHPAWAIDTSKLSSVAISRDTQKHYDVRTKCLAKFSSIYGPLP 274
            V   W          A+S D   H+  R KC+  F  +YG +P
Sbjct: 851  VTSRWTFRCPGCPQ-ALSHD-DSHFHERHKCINFFVKVYGYMP 891

>EXTL3_MOUSE (Q9WVL6) Exostosin-like 3 (EC 2.4.1.-) (Multiple exostosis-like|
            protein 3)
          Length = 918

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 32/103 (31%), Positives = 50/103 (48%)
 Frame = -1

Query: 582  TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
            +++LTGAAF    +A+  Y     +  RD V +  NCED+ MNF+ ++ +    R+    
Sbjct: 795  SMVLTGAAFFHKYYAYL-YSYVMPQAIRDMVDEYINCEDIAMNFLVSHIT----RKPPIK 849

Query: 402  VHPAWAIDTSKLSSVAISRDTQKHYDVRTKCLAKFSSIYGPLP 274
            V   W          A+S D   H+  R KC+  F  +YG +P
Sbjct: 850  VTSRWTFRCPGCPQ-ALSHD-DSHFHERHKCINFFVKVYGYMP 890

>EXT3_DROME (Q9XZ08) Exostosin-3 (EC 2.4.1.223) (Protein brother of tout-velu)|
          Length = 972

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 31/103 (30%), Positives = 51/103 (49%)
 Frame = -1

Query: 582  TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
            +++LTGAAF+   + +  Y     +  RD V +  NCED+ MNF+ ++ +    R+    
Sbjct: 849  SMVLTGAAFVHKYYLYL-YTYHLPQAIRDKVDEYMNCEDIAMNFLVSHIT----RKPPVK 903

Query: 402  VHPAWAIDTSKLSSVAISRDTQKHYDVRTKCLAKFSSIYGPLP 274
            V   W         V++S D   H+  R KC+  FS ++G  P
Sbjct: 904  VTSRWTFRCPG-CPVSLSED-DTHFQERHKCINFFSRVFGYTP 944

>EXT1C_BRARE (Q5IGR6) Exostosin-1c (EC 2.4.1.224) (EC 2.4.1.225)|
           (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-
           acetylglucosaminyl-proteoglycan
           4-alpha-N-acetylglucosaminyltransferase 1c) (Multiple
           exostoses protein 1 homolog c)
          Length = 737

 Score = 38.5 bits (88), Expect = 0.016
 Identities = 30/112 (26%), Positives = 51/112 (45%), Gaps = 9/112 (8%)
 Frame = -1

Query: 582 TLILTGAAFMDSEF--AFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTV 409
           ++ILTGAAF    +   F  Y     R   D+   + NCED+LMNF+ +         +V
Sbjct: 608 SIILTGAAFYHRYYHHLFSHYLPSSLRALVDH---SCNCEDILMNFLVS---------SV 655

Query: 408 EYVHPAWAIDTSKLSSVAISRDTQ-------KHYDVRTKCLAKFSSIYGPLP 274
            ++ P       +   +   + T+       +H+  R +C+  FSS +G +P
Sbjct: 656 AHLPPVKVAQRKQYKEMPSLQGTKMAPWANPEHFTQRQECVNTFSSWFGYMP 707

>EXTL2_MOUSE (Q9ES89) Exostosin-like 2 (EC 2.4.1.223)|
           (Glucuronyl-galactosyl-proteoglycan
           4-alpha-N-acetylglucosaminyltransferase)
           (Alpha-1,4-N-acetylhexosaminyltransferase EXTL2)
           (Alpha-GalNAcT EXTL2) (EXT-related protein 2)
          Length = 330

 Score = 37.7 bits (86), Expect = 0.027
 Identities = 30/118 (25%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
 Frame = -1

Query: 603 PGARRATTLILTGAAFMDSEFAFKRYWSEXARKGRDYVH----KNFNCEDLLMNFMYANA 436
           PG     +++L GA+F +S++       E  +K    VH    +  NC+D+ MNF+    
Sbjct: 203 PGNGDQYSMVLIGASFFNSKYL------ELFQKQPAAVHALIDETQNCDDIAMNFL---V 253

Query: 435 SSGTGRRTVEYVHPAWAIDTSK-LSSVAISRDTQKHYDVRTKCLAKFSSIYGPLPQKW 265
           +  TG+ +  +V P   ++  K  +  +      +H+  R+ C+ K  +IY  +P K+
Sbjct: 254 TRHTGKPSGIFVKPINMVNLEKETNGYSGMWHRAEHFLQRSYCINKLVNIYDGMPLKY 311

>EXT1A_BRARE (Q5IGR8) Exostosin-1a (EC 2.4.1.224) (EC 2.4.1.225)|
           (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-
           acetylglucosaminyl-proteoglycan
           4-alpha-N-acetylglucosaminyltransferase 1a) (Multiple
           exostoses protein 1 homolog a)
          Length = 730

 Score = 37.4 bits (85), Expect = 0.035
 Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 2/105 (1%)
 Frame = -1

Query: 582 TLILTGAAFMDSEFAFK-RYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVE 406
           +++LTGAAF    + +   ++   + KG   V +  NCED+LMNF+    S+ T    ++
Sbjct: 601 SMVLTGAAFYHRYYNYLYTHYLPGSLKG--LVDQLSNCEDILMNFL---VSAVTKMPPIK 655

Query: 405 YVHPAWAIDTSKLSSVAISR-DTQKHYDVRTKCLAKFSSIYGPLP 274
                   +T    +   SR     H+  R  C+ KF+S +G +P
Sbjct: 656 VTQKKQYKETMMGQTSRASRWADPDHFAQRQTCMNKFASWFGTMP 700

>EXT1B_BRARE (Q5IGR7) Exostosin-1b (EC 2.4.1.224) (EC 2.4.1.225)|
           (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-
           acetylglucosaminyl-proteoglycan
           4-alpha-N-acetylglucosaminyltransferase 1b) (Multiple
           exostoses protein 1 homolog b)
          Length = 741

 Score = 37.0 bits (84), Expect = 0.045
 Identities = 31/104 (29%), Positives = 47/104 (45%), Gaps = 1/104 (0%)
 Frame = -1

Query: 582 TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
           +++LTGAA     + F  Y        +  V +  NCED+LMNF+    S+ T    V+ 
Sbjct: 612 SMVLTGAAIYHRYYHFL-YTHFLPSSLKSMVDQLANCEDILMNFL---VSAVTKLPPVKV 667

Query: 402 VHPAWAIDTSKLSSVAISR-DTQKHYDVRTKCLAKFSSIYGPLP 274
                  +T    S   SR     H+  R  C+ KF+S +G +P
Sbjct: 668 TQKKQYKETMMGQSSRASRWADPDHFAQRQTCMNKFASWFGGMP 711

>ARGI_YEAST (P00812) Arginase (EC 3.5.3.1)|
          Length = 333

 Score = 35.8 bits (81), Expect = 0.10
 Identities = 16/31 (51%), Positives = 20/31 (64%)
 Frame = +1

Query: 208 PHCPESRLFVPAILSPAKLPFLRQRAVYGGE 300
           PHCPES  +VP  LSP K+ ++  R V  GE
Sbjct: 178 PHCPESLKWVPGNLSPKKIAYIGLRDVDAGE 208

>EXT1_CRIGR (Q9JK82) Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Heparan sulfate|
           copolymerase) (Multiple exostoses protein 1 homolog)
          Length = 746

 Score = 33.1 bits (74), Expect = 0.66
 Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 1/104 (0%)
 Frame = -1

Query: 582 TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
           +++LTGAA     + +  Y        ++ V +  NCED+LMNF+    S+ T    ++ 
Sbjct: 617 SMVLTGAAIYHKYYHYL-YTHYLPASLKNMVDQLANCEDILMNFL---VSAVTKLPPIKV 672

Query: 402 VHPAWAIDTSKLSSVAISR-DTQKHYDVRTKCLAKFSSIYGPLP 274
                  +T    +   SR     H+  R  C+  F+S +G +P
Sbjct: 673 TQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMP 716

>EXT1_MOUSE (P97464) Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225)|
           (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-
           acetylglucosaminyl-proteoglycan
           4-alpha-N-acetylglucosaminyltransferase) (Multiple
           exostoses protein 1 homolog)
          Length = 746

 Score = 32.7 bits (73), Expect = 0.86
 Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 1/104 (0%)
 Frame = -1

Query: 582 TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
           +++LTGAA     + +  Y        ++ V +  NCED+LMNF+    S+ T    ++ 
Sbjct: 617 SMVLTGAAIYHKYYHYL-YSHYLPASLKNMVDQLANCEDILMNFL---VSAVTKLPPIKV 672

Query: 402 VHPAWAIDTSKLSSVAISR-DTQKHYDVRTKCLAKFSSIYGPLP 274
                  +T    +   SR     H+  R  C+  F+S +G +P
Sbjct: 673 TQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMP 716

>EXT1_HUMAN (Q16394) Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225)|
           (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-
           acetylglucosaminyl-proteoglycan
           4-alpha-N-acetylglucosaminyltransferase) (Putative tumor
           suppressor protein EXT1) (Multiple exostoses protein
          Length = 746

 Score = 32.7 bits (73), Expect = 0.86
 Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 1/104 (0%)
 Frame = -1

Query: 582 TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
           +++LTGAA     + +  Y        ++ V +  NCED+LMNF+    S+ T    ++ 
Sbjct: 617 SMVLTGAAIYHKYYHYL-YSHYLPASLKNMVDQLANCEDILMNFL---VSAVTKLPPIKV 672

Query: 402 VHPAWAIDTSKLSSVAISR-DTQKHYDVRTKCLAKFSSIYGPLP 274
                  +T    +   SR     H+  R  C+  F+S +G +P
Sbjct: 673 TQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMP 716

>EXT1_DROME (Q9V730) Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Protein|
           tout-velu)
          Length = 760

 Score = 32.3 bits (72), Expect = 1.1
 Identities = 26/103 (25%), Positives = 48/103 (46%)
 Frame = -1

Query: 582 TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
           +++LTGAAF    + +  Y +  +      V ++ NCED+LMN + ++    T +  ++ 
Sbjct: 633 SIVLTGAAFYHRYYNYL-YTNWLSLLLLKTVQQSSNCEDILMNLLVSHV---TRKPPIKV 688

Query: 402 VHPAWAIDTSKLSSVAISRDTQKHYDVRTKCLAKFSSIYGPLP 274
                  D     S     D   H+  R  CL  F++++G +P
Sbjct: 689 TQRKGYKDRETGRSPWNDPD---HFIQRQSCLNTFAAVFGYMP 728

>CLC14_MOUSE (Q8VCP9) C-type lectin domain family 14 member A precursor|
          Length = 459

 Score = 32.0 bits (71), Expect = 1.5
 Identities = 15/38 (39%), Positives = 18/38 (47%)
 Frame = +3

Query: 201 FPPPLSRVQAICPSHLVACQTPISEAEGRIWRRTWPGT 314
           F PP + V A+CP  L    T I E     W   +PGT
Sbjct: 205 FSPPGTEVSAMCPGDLSVSSTCIQEETSAHWDGLFPGT 242

>EXTL2_HUMAN (Q9UBQ6) Exostosin-like 2 (EC 2.4.1.223)|
           (Glucuronyl-galactosyl-proteoglycan
           4-alpha-N-acetylglucosaminyltransferase)
           (Alpha-1,4-N-acetylhexosaminyltransferase EXTL2)
           (Alpha-GalNAcT EXTL2) (EXT-related protein 2)
          Length = 330

 Score = 31.2 bits (69), Expect = 2.5
 Identities = 24/108 (22%), Positives = 49/108 (45%), Gaps = 2/108 (1%)
 Frame = -1

Query: 582 TLILTGAAFMDSEFAFKRYWSEXARKGRDYVHKNFNCEDLLMNFMYANASSGTGRRTVEY 403
           +++L GA+F +S++     +          +    NC+D+ MNF+ A      G+ +  +
Sbjct: 209 SMVLIGASFFNSKYL--ELFQRQPAAVHALIDDTQNCDDIAMNFIIA---KHIGKTSGIF 263

Query: 402 VHPAWAIDTSKLSSVAISR--DTQKHYDVRTKCLAKFSSIYGPLPQKW 265
           V P    +  K ++   S      +H   R+ C+ K  +IY  +P ++
Sbjct: 264 VKPVNMDNLEKETNSGYSGMWHRAEHALQRSYCINKLVNIYDSMPLRY 311


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,999,612
Number of Sequences: 219361
Number of extensions: 1851494
Number of successful extensions: 5207
Number of sequences better than 10.0: 19
Number of HSP's better than 10.0 without gapping: 5020
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5192
length of database: 80,573,946
effective HSP length: 107
effective length of database: 57,102,319
effective search space used: 5481822624
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)