>MTHR_ORYSA (Q75HE6) Probable methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 594

 Score =  297 bits (760), Expect = 2e-80
 Identities = 141/166 (84%), Positives = 154/166 (92%)
 Frame = -2

Query: 592 VXMNSKGFXTINSQXAVNAEKXESPSVGWGGPXGYVYQKAYVEFXCAKEKLDQLIEKSKA 413
           V +N KGF TINSQ AVN E+ +S SVGWGGP GYVYQKAY+EF C+KEKLDQLIEKSKA
Sbjct: 429 VKINQKGFLTINSQPAVNGERSDSTSVGWGGPGGYVYQKAYLEFFCSKEKLDQLIEKSKA 488

Query: 412 FPSLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFEIWS 233
           FPSLTYIAVNK+GES SNIP NAVNAVTWGVFPGKEI+QPTVVDSASFMVWKDEAFEIWS
Sbjct: 489 FPSLTYIAVNKDGESFSNIPTNAVNAVTWGVFPGKEIVQPTVVDSASFMVWKDEAFEIWS 548

Query: 232 RGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISGDLFAAFKEI 95
           +GWACLFPEGDSSRE+L++VQK+Y LVSLVDNDYI+GDLFAAFKEI
Sbjct: 549 KGWACLFPEGDSSREILDKVQKSYFLVSLVDNDYINGDLFAAFKEI 594

>MTHR1_MAIZE (Q9SE94) Methylenetetrahydrofolate reductase 1 (EC 1.5.1.20)|
           (ZmMTHFR1)
          Length = 593

 Score =  290 bits (741), Expect = 3e-78
 Identities = 138/164 (84%), Positives = 148/164 (90%)
 Frame = -2

Query: 592 VXMNSKGFXTINSQXAVNAEKXESPSVGWGGPXGYVYQKAYVEFXCAKEKLDQLIEKSKA 413
           V +N KGF TINSQ AVN EK +SP+VGWGGP GYVYQKAY+EF CAKEKLDQLIEK KA
Sbjct: 429 VNINQKGFLTINSQPAVNGEKSDSPTVGWGGPGGYVYQKAYLEFFCAKEKLDQLIEKIKA 488

Query: 412 FPSLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFEIWS 233
           FPSLTYIAVNK+GE+ SNI  NAVNAVTWGVFPGKEIIQPTVVD ASFMVWKDEAFEIW+
Sbjct: 489 FPSLTYIAVNKDGETFSNISPNAVNAVTWGVFPGKEIIQPTVVDHASFMVWKDEAFEIWT 548

Query: 232 RGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISGDLFAAFK 101
           RGW C+FPEGDSSRELLE+VQKTY LVSLVDNDY+ GDLFAAFK
Sbjct: 549 RGWGCMFPEGDSSRELLEKVQKTYYLVSLVDNDYVQGDLFAAFK 592

>MTHR1_ARATH (Q9SE60) Methylenetetrahydrofolate reductase 1 (EC 1.5.1.20)|
           (AtMTHFR1)
          Length = 592

 Score =  241 bits (615), Expect = 1e-63
 Identities = 111/161 (68%), Positives = 135/161 (83%)
 Frame = -2

Query: 586 MNSKGFXTINSQXAVNAEKXESPSVGWGGPXGYVYQKAYVEFXCAKEKLDQLIEKSKAFP 407
           +NS GF TINSQ +VNA K +SP++GWGGP GYVYQKAY+EF C+K+KLD L+EKSKAFP
Sbjct: 431 INSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAYLEFFCSKDKLDTLVEKSKAFP 490

Query: 406 SLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFEIWSRG 227
           S+TY+AVNK    +SN   + VNAVTWGVFP KE+IQPT+VD ASF VWKDEAFEIWSR 
Sbjct: 491 SITYMAVNKSENWVSNTGESDVNAVTWGVFPAKEVIQPTIVDPASFKVWKDEAFEIWSRS 550

Query: 226 WACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISGDLFAAF 104
           WA L+PE D SR+LLE+V+ +Y LVSLVDN+YI+GD+F+ F
Sbjct: 551 WANLYPEDDPSRKLLEEVKNSYYLVSLVDNNYINGDIFSVF 591

>MTHR2_ARATH (O80585) Methylenetetrahydrofolate reductase 2 (EC 1.5.1.20)|
           (AtMTHFR2)
          Length = 594

 Score =  241 bits (615), Expect = 1e-63
 Identities = 112/166 (67%), Positives = 136/166 (81%)
 Frame = -2

Query: 592 VXMNSKGFXTINSQXAVNAEKXESPSVGWGGPXGYVYQKAYVEFXCAKEKLDQLIEKSKA 413
           + +NSKGF TINSQ +VNAE+ +SP+VGWGGP GYVYQKAY+EF C+KEKLD ++EK KA
Sbjct: 429 IKVNSKGFLTINSQPSVNAERSDSPTVGWGGPVGYVYQKAYLEFFCSKEKLDAVVEKCKA 488

Query: 412 FPSLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFEIWS 233
            PS+TY+AVNK  + +SN     VNAVTWGVFP KEIIQPT+VD ASF VWKDEAFE WS
Sbjct: 489 LPSITYMAVNKGEQWVSNTAQADVNAVTWGVFPAKEIIQPTIVDPASFNVWKDEAFETWS 548

Query: 232 RGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISGDLFAAFKEI 95
           R WA L+PE D SR LLE+V+ +Y LVSLV+NDYI+GD+FA F ++
Sbjct: 549 RSWANLYPEADPSRNLLEEVKNSYYLVSLVENDYINGDIFAVFADL 594

>MTHR_HUMAN (P42898) Methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 656

 Score =  156 bits (395), Expect = 4e-38
 Identities = 74/153 (48%), Positives = 100/153 (65%), Gaps = 1/153 (0%)
 Frame = -2

Query: 586 MNSKGFXTINSQXAVNAEKXESPSVGWGGPXGYVYQKAYVEFXCAKEKLDQLIEKSKAFP 407
           +N +G  TINSQ  +N +    P VGWG   GYV+QKAY+EF  ++E  + L++  K + 
Sbjct: 474 VNRQGILTINSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYE 533

Query: 406 -SLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFEIWSR 230
             + Y  VN +GE+I+N P    NAVTWG+FPG+EIIQPTVVD  SFM WKDEAF +W  
Sbjct: 534 LRVNYHLVNVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIE 593

Query: 229 GWACLFPEGDSSRELLEQVQKTYCLVSLVDNDY 131
            W  L+ E   SR +++ +   Y LV+LVDND+
Sbjct: 594 RWGKLYEEESPSRTIIQYIHDNYFLVNLVDNDF 626

>MTHR_MACFA (Q60HE5) Methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 656

 Score =  156 bits (394), Expect = 5e-38
 Identities = 74/153 (48%), Positives = 100/153 (65%), Gaps = 1/153 (0%)
 Frame = -2

Query: 586 MNSKGFXTINSQXAVNAEKXESPSVGWGGPXGYVYQKAYVEFXCAKEKLDQLIEKSKAFP 407
           +N +G  TINSQ  +N +    P VGWG   GYV+QKAY+EF  ++E  + L++  K + 
Sbjct: 474 VNRQGILTINSQPNINGKPSSDPVVGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYE 533

Query: 406 -SLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFEIWSR 230
             + Y  VN +GE+I+N P    NAVTWG+FPG+EIIQPTVVD  SFM WKDEAF +W  
Sbjct: 534 LRVNYHLVNVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPISFMFWKDEAFALWIE 593

Query: 229 GWACLFPEGDSSRELLEQVQKTYCLVSLVDNDY 131
            W  L+ E   SR +++ +   Y LV+LVDND+
Sbjct: 594 QWGKLYEEESPSRTIIQYIHDNYFLVNLVDNDF 626

>MTHR_MOUSE (Q9WU20) Methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 654

 Score =  154 bits (388), Expect = 2e-37
 Identities = 73/153 (47%), Positives = 101/153 (66%), Gaps = 1/153 (0%)
 Frame = -2

Query: 586 MNSKGFXTINSQXAVNAEKXESPSVGWGGPXGYVYQKAYVEFXCAKEKLDQLIEKSKAFP 407
           +N  G  TINSQ  +NA+    P VGWG   GYV+QKAY+EF  ++E ++ L++  K + 
Sbjct: 473 VNRLGILTINSQPNINAKPSSDPVVGWGPSGGYVFQKAYLEFFTSRETVEALLQVLKTYE 532

Query: 406 -SLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFEIWSR 230
             + Y  V+ +GE+I+N P    NAVTWG+FPG+EIIQPTVVD  SFM WKDEAF +W  
Sbjct: 533 LRVNYHIVDVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPISFMFWKDEAFALWIE 592

Query: 229 GWACLFPEGDSSRELLEQVQKTYCLVSLVDNDY 131
            W  L+ E   SR +++ +   Y LV+LVDN++
Sbjct: 593 QWGKLYEEESPSRMIIQYIHDNYFLVNLVDNEF 625

>MTHR1_SCHPO (Q10258) Methylenetetrahydrofolate reductase 1 (EC 1.5.1.20)|
          Length = 603

 Score =  146 bits (368), Expect = 5e-35
 Identities = 76/167 (45%), Positives = 100/167 (59%), Gaps = 1/167 (0%)
 Frame = -2

Query: 592 VXMNSKGFXTINSQXAVNAEKXESPSVGWGGPXGYVYQKAYVEFXCAKEKLDQLIEKSKA 413
           + MN   F TINSQ A+N EK   P  GWG P GYV+QK YVEF      L++L E  K 
Sbjct: 422 LSMNRNAFLTINSQPALNGEKSSHPVFGWGPPNGYVFQKPYVEFFVHPSLLNELKETVKK 481

Query: 412 FPSLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFEIWS 233
             S++Y   NK G+  +N      NAVTWGVFP +EIIQPT+V+S SF+ WKDEA+ +  
Sbjct: 482 LNSVSYFVTNKNGDLDTNSQYEIPNAVTWGVFPNREIIQPTIVESTSFLAWKDEAYSL-G 540

Query: 232 RGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISG-DLFAAFKEI 95
             WA  +     SR+LL  + K + L  +VDND+ +G  LF  F ++
Sbjct: 541 MEWANAYSPDSISRKLLVSMMKEWFLCVIVDNDFQNGQSLFDVFNKM 587

>MTHR2_YEAST (P53128) Methylenetetrahydrofolate reductase 2 (EC 1.5.1.20)|
          Length = 599

 Score =  138 bits (347), Expect = 1e-32
 Identities = 71/161 (44%), Positives = 99/161 (61%), Gaps = 3/161 (1%)
 Frame = -2

Query: 592 VXMNSKGFXTINSQXAVNAEKXESPSVGWGGPXGYVYQKAYVEFXCAKEKLDQLIEKSKA 413
           + +N     TINSQ  VN  +      GWG   GYVYQK Y+EF   K KL +LI+  K 
Sbjct: 430 IELNQHSIITINSQPQVNGIRSNDKIHGWGPKDGYVYQKQYLEFMLPKTKLPKLIDTLKN 489

Query: 412 FPSLTYIAVNKEGESISNIPANA-VNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFEIW 236
              LTY A++ +G+ +SN P N+  NAVTWG+FPG+EI+QPT+V+  SF+ WK+E + I 
Sbjct: 490 NEFLTYFAIDSQGDLLSNHPDNSKSNAVTWGIFPGREILQPTIVEKISFLAWKEEFYHIL 549

Query: 235 SRGWACLFPEGDS--SRELLEQVQKTYCLVSLVDNDYISGD 119
           +  W     + D   S + ++ +   YCLV++VDNDYIS D
Sbjct: 550 NE-WKLNMNKYDKPHSAQFIQSLIDDYCLVNIVDNDYISPD 589

>MTHR_CAEEL (Q17693) Probable methylenetetrahydrofolate reductase (EC 1.5.1.20)|
          Length = 663

 Score =  131 bits (329), Expect = 2e-30
 Identities = 69/157 (43%), Positives = 91/157 (57%), Gaps = 3/157 (1%)
 Frame = -2

Query: 592 VXMNSKGFXTINSQXAVNAEKXESPSVGWGGPXGYVYQKAYVEFXCAKEKLDQLIEK-SK 416
           V  N  G  T+NSQ +VN      P VGWG P GY YQKAY+E     E  D+LI+   +
Sbjct: 488 VWCNENGILTVNSQPSVNGAPSTDPLVGWGKPGGYCYQKAYLECFMTAELSDKLIQIIER 547

Query: 415 AFP-SLTYIAVNKEGE-SISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFE 242
            FP  + Y A+NK+     +N       AVTWGVFPG EI QPTVVD  SF  W+DEA++
Sbjct: 548 EFPVRVNYHAINKDSTFDKTNSEETTPIAVTWGVFPGSEIAQPTVVDPLSFRAWRDEAYQ 607

Query: 241 IWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDY 131
           +W   W   +P+   S  +++ V   + LV+LVDND+
Sbjct: 608 MWMAQWGDFYPKESKSYGVIKAVHDEFRLVTLVDNDF 644

>MTHR2_SCHPO (O74927) Methylenetetrahydrofolate reductase 2 (EC 1.5.1.20)|
          Length = 641

 Score =  119 bits (299), Expect = 5e-27
 Identities = 59/153 (38%), Positives = 87/153 (56%)
 Frame = -2

Query: 586 MNSKGFXTINSQXAVNAEKXESPSVGWGGPXGYVYQKAYVEFXCAKEKLDQLIEKSKAFP 407
           +N   + T+ SQ AVN      P  GWG   G V+QKA+VE     + L   I K    P
Sbjct: 477 LNGNSWWTVGSQPAVNGAPSADPVFGWGPKGGRVFQKAFVECFVNGKDLKDFITKWHDNP 536

Query: 406 SLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFEIWSRG 227
            +TY A N + E ++N P +  +AVTWGV+PG+EIIQ T++   SF  W  E+F++W   
Sbjct: 537 QVTYYAGNNKSEFLTNAPKDGASAVTWGVYPGREIIQSTIIAEVSFKAWLSESFQVWGE- 595

Query: 226 WACLFPEGDSSRELLEQVQKTYCLVSLVDNDYI 128
           WA L+ +   SR+LLE       LV+++ +D++
Sbjct: 596 WANLYSKNTPSRKLLENCINDRWLVTVIHHDFM 628

>MTHR1_YEAST (P46151) Methylenetetrahydrofolate reductase 1 (EC 1.5.1.20)|
          Length = 657

 Score =  113 bits (283), Expect = 4e-25
 Identities = 58/161 (36%), Positives = 87/161 (54%), Gaps = 3/161 (1%)
 Frame = -2

Query: 592 VXMNSKGFXTINSQXAVNAEKXESPSVGWGGPXGYVYQKAYVEFXCAKEKLDQLIEKSKA 413
           + +N +G+ T+ SQ A NA        GWG   G +YQKA+VE    +++ +  ++    
Sbjct: 488 IQLNYRGYLTLASQPATNATLSSDKIFGWGPAKGRLYQKAFVEMFIHRQQWETTLKPKLD 547

Query: 412 F---PSLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFE 242
                  +Y A +  G   +N+  ++ + VTWGVFP   + Q T+++  SF  W+DEAF 
Sbjct: 548 HYGRRKFSYYAGDSSGSFETNLDPHSSSVVTWGVFPNSPVKQTTIIEEESFKAWRDEAFS 607

Query: 241 IWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISGD 119
           IWS  WA LFP    +  LL  V K YCLVS+V +D+   D
Sbjct: 608 IWSE-WAKLFPRNTPANILLRLVHKDYCLVSIVHHDFKETD 647

>PROS_RABIT (P98118) Vitamin K-dependent protein S precursor (Fragment)|
          Length = 646

 Score = 32.3 bits (72), Expect = 1.1
 Identities = 14/43 (32%), Positives = 22/43 (51%)
 Frame = -2

Query: 232 RGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISGDLFAAF 104
           RGW  +       +E+++Q QK +CLV++    Y  G   A F
Sbjct: 422 RGWNLMKQGASGVKEIIQQKQKKHCLVTVEKGSYYPGSGIAQF 464

>YB1C_SCHPO (P87177) Hypothetical WD-repeat protein C3D6.12 in chromosome II|
          Length = 922

 Score = 30.8 bits (68), Expect = 3.1
 Identities = 21/62 (33%), Positives = 31/62 (50%)
 Frame = -2

Query: 301 IQPTVVDSASFMVWKDEAFEIWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISG 122
           + PT V S S     D +  +W +G   +F E +  REL EQ + T  LVS  +N    G
Sbjct: 668 VGPTFVVSGSH----DHSIRLWEQGDDLVFLEEERERELEEQYEST--LVSSYENAEADG 721

Query: 121 DL 116
           ++
Sbjct: 722 EV 723

>BUN2_DROME (Q24523) Protein bunched, class 2 isoform (Protein shortsighted)|
          Length = 1206

 Score = 30.4 bits (67), Expect = 4.0
 Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 9/63 (14%)
 Frame = -2

Query: 376 GESISNIPANA----VNAVTWGVFPG----KEIIQPTVVDSASFMVWKDEAFEIWSRG-W 224
           G++I N+  N     +N V+  V PG    K+ I+ T   S  F V K E+ E + RG W
Sbjct: 466 GQTIQNVQVNVSDNIINVVSGAVTPGGTKKKDDIKETQHRSERFKVVKIESTEPFKRGRW 525

Query: 223 ACL 215
            C+
Sbjct: 526 MCM 528

>DXR_LEIXX (Q6AEY1) 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC|
           1.1.1.267) (DXP reductoisomerase)
           (1-deoxyxylulose-5-phosphate reductoisomerase)
           (2-C-methyl-D-erythritol 4-phosphate synthase)
          Length = 361

 Score = 30.0 bits (66), Expect = 5.3
 Identities = 11/24 (45%), Positives = 14/24 (58%)
 Frame = +1

Query: 178 ALATPWMSHPPGTGRPIPWTRSQT 249
           +L   W    PGTG P+ WTR+ T
Sbjct: 247 SLGLGWPDRVPGTGLPLDWTRAHT 270

>KLK10_RAT (P36375) Glandular kallikrein-10 precursor (EC 3.4.21.35) (Tissue|
           kallikrein) (T-kininogenase) (K10) (Proteinase B)
           (Endopeptidase K) [Contains: T-kininogenase light chain;
           T-kininogenase heavy chain] (Fragment)
          Length = 244

 Score = 29.3 bits (64), Expect = 9.0
 Identities = 15/41 (36%), Positives = 21/41 (51%)
 Frame = +2

Query: 230 PGPDLKRFIFPNHEARRVNDGRLDDLLAGEHAPSDSVHGVR 352
           P PD K F+  NH  +R +D   D +L     P+D   GV+
Sbjct: 80  PHPDYKPFLMRNHTRQRGDDYSNDLMLLHLSEPADITDGVK 120

>XYLA_STRLI (Q9RFM4) Xylose isomerase (EC 5.3.1.5)|
          Length = 395

 Score = 29.3 bits (64), Expect = 9.0
 Identities = 13/34 (38%), Positives = 19/34 (55%)
 Frame = -2

Query: 247 FEIWSRGWACLFPEGDSSRELLEQVQKTYCLVSL 146
           F +W+ GW  L P GD++RE L+  +    L  L
Sbjct: 13  FGLWTVGWQGLDPFGDATREALDPAESVRRLSQL 46


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,614,846
Number of Sequences: 219361
Number of extensions: 1771332
Number of successful extensions: 4647
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 4451
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4631
length of database: 80,573,946
effective HSP length: 106
effective length of database: 57,321,680
effective search space used: 5216272880
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)