>TBC13_MOUSE (Q8R3D1) TBC1 domain family member 13|
          Length = 400

 Score =  143 bits (360), Expect = 6e-34
 Identities = 79/170 (46%), Positives = 108/170 (63%), Gaps = 11/170 (6%)
 Frame = -2

Query: 635 GMIQIIKILYGNFA-----------EADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLS 489
           GM +I+  LY  FA           EAD+FFCF  L++ +RDNF + LD+S  GI   + 
Sbjct: 230 GMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIRDNFIKSLDDSQCGITYKME 289

Query: 488 KLMQLLKKYDGELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGP 309
           K+   LK  D EL   L+    + PQF+AFRW+TLLL+QEF   D I IWD+L +D +  
Sbjct: 290 KVYSTLKDKDVELYLKLQ-EQSIKPQFFAFRWLTLLLSQEFLLPDVIRIWDSLFADGNR- 347

Query: 308 QETLLRICCAMLILVRKRLLAGDFTSNLKLLQSYPPTNIGHLLYVANKLQ 159
            + LL +CCAMLIL+R++LL GDFT N++LLQ YP T++  +L  A +LQ
Sbjct: 348 FDFLLLVCCAMLILIREQLLEGDFTVNMRLLQDYPITDVCQILQKAKELQ 397



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 26/41 (63%), Positives = 30/41 (73%)
 Frame = -1

Query: 723 ILIIFAKLNAGIRYVQGMNEILAPLFFVFRNDPDYKNSVWK 601
           IL I+AKLN GI YVQGMNEI+ PL++ F  DP   NS WK
Sbjct: 214 ILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDP---NSEWK 251

>TBC13_HUMAN (Q9NVG8) TBC1 domain family member 13|
          Length = 275

 Score =  100 bits (249), Expect = 5e-21
 Identities = 47/88 (53%), Positives = 65/88 (73%)
 Frame = -2

Query: 422 VNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCAMLILVRKRLLAG 243
           + PQF+AFRW+TLLL+QEF   D   IWD+L +D D   + LL +CCAML+L+R++LL G
Sbjct: 186 IKPQFFAFRWLTLLLSQEFLLPDVTRIWDSLFAD-DNRFDFLLLVCCAMLMLIREQLLEG 244

Query: 242 DFTSNLKLLQSYPPTNIGHLLYVANKLQ 159
           DFT N++LLQ YP T++  +L  A +LQ
Sbjct: 245 DFTVNMRLLQDYPITDVCQILQKAKELQ 272

>TB22B_MACFA (Q95LL3) TBC1 domain family member 22B|
          Length = 505

 Score = 80.9 bits (198), Expect(2) = 6e-18
 Identities = 56/153 (36%), Positives = 82/153 (53%), Gaps = 6/153 (3%)
 Frame = -2

Query: 593 EADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYDGELQHHLEITTEVNP 414
           EADSF+C  +LL G++DN+      +  GI+  +  L +L+ + D ++ +H     EV  
Sbjct: 348 EADSFWCMSKLLDGIQDNYTF----AQPGIQKKVKALEELVSRIDEQVHNHFR-RYEVEY 402

Query: 413 QFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCAMLILVRKRLL-AGDF 237
             +AFRW+  LL +E     TI +WDT  S+P+G     L +C A LI  RK +L   DF
Sbjct: 403 LQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDF 462

Query: 236 TSNLKLLQSYPPTN-----IGHLLYVANKLQ*M 153
              L LLQ+ P  +     IG LL  A +L+ M
Sbjct: 463 QGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYM 495



 Score = 29.6 bits (65), Expect(2) = 6e-18
 Identities = 13/32 (40%), Positives = 21/32 (65%)
 Frame = -1

Query: 723 ILIIFAKLNAGIRYVQGMNEILAPLFFVFRND 628
           IL I+A  +    YVQG+N+++ P F VF ++
Sbjct: 294 ILFIWAIRHPASGYVQGINDLVTPFFVVFLSE 325

>TB22B_HUMAN (Q9NU19) TBC1 domain family member 22B|
          Length = 505

 Score = 80.9 bits (198), Expect(2) = 6e-18
 Identities = 56/153 (36%), Positives = 82/153 (53%), Gaps = 6/153 (3%)
 Frame = -2

Query: 593 EADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYDGELQHHLEITTEVNP 414
           EADSF+C  +LL G++DN+      +  GI+  +  L +L+ + D ++ +H     EV  
Sbjct: 348 EADSFWCMSKLLDGIQDNYTF----AQPGIQKKVKALEELVSRIDEQVHNHFR-RYEVEY 402

Query: 413 QFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCAMLILVRKRLL-AGDF 237
             +AFRW+  LL +E     TI +WDT  S+P+G     L +C A LI  RK +L   DF
Sbjct: 403 LQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDF 462

Query: 236 TSNLKLLQSYPPTN-----IGHLLYVANKLQ*M 153
              L LLQ+ P  +     IG LL  A +L+ M
Sbjct: 463 QGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYM 495



 Score = 29.6 bits (65), Expect(2) = 6e-18
 Identities = 13/32 (40%), Positives = 21/32 (65%)
 Frame = -1

Query: 723 ILIIFAKLNAGIRYVQGMNEILAPLFFVFRND 628
           IL I+A  +    YVQG+N+++ P F VF ++
Sbjct: 294 ILFIWAIRHPASGYVQGINDLVTPFFVVFLSE 325

>TB22A_HUMAN (Q8WUA7) TBC1 domain family member 22A|
          Length = 517

 Score = 77.4 bits (189), Expect(2) = 9e-17
 Identities = 47/131 (35%), Positives = 72/131 (54%), Gaps = 1/131 (0%)
 Frame = -2

Query: 593 EADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYDGELQHHLEITTEVNP 414
           EAD+++C  +LL G++DN+      +  GI+  +  L +L+ + D ++  HL+   EV  
Sbjct: 360 EADTYWCMSKLLDGIQDNYTF----AQPGIQMKVKMLEELVSRIDEQVHRHLD-QHEVRY 414

Query: 413 QFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCAMLILVRKRLL-AGDF 237
             +AFRW+  LL +E     TI +WDT  S+PDG     L +C A L+  RK +L   DF
Sbjct: 415 LQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDF 474

Query: 236 TSNLKLLQSYP 204
              L  LQ+ P
Sbjct: 475 QELLLFLQNLP 485



 Score = 29.3 bits (64), Expect(2) = 9e-17
 Identities = 13/29 (44%), Positives = 19/29 (65%)
 Frame = -1

Query: 723 ILIIFAKLNAGIRYVQGMNEILAPLFFVF 637
           IL I+A  +    YVQG+N+++ P F VF
Sbjct: 305 ILFIWAIRHPASGYVQGINDLVTPFFVVF 333

>TB22A_MACFA (Q95KI1) TBC1 domain family member 22A (Fragment)|
          Length = 497

 Score = 75.9 bits (185), Expect(2) = 3e-16
 Identities = 46/131 (35%), Positives = 72/131 (54%), Gaps = 1/131 (0%)
 Frame = -2

Query: 593 EADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYDGELQHHLEITTEVNP 414
           EAD+++C  +LL G++DN+      +  GI+  +  L +L+ + D ++  HL+   EV  
Sbjct: 340 EADTYWCMSKLLDGIQDNYTF----AQPGIQMKVKMLEELVSRIDEQVHRHLD-QHEVRY 394

Query: 413 QFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCAMLILVRKRLL-AGDF 237
             +AFRW+  LL +E     TI +WDT  S+P+G     L +C A L+  RK +L   DF
Sbjct: 395 LQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLVRWRKEILEEKDF 454

Query: 236 TSNLKLLQSYP 204
              L  LQ+ P
Sbjct: 455 QELLLFLQNLP 465



 Score = 29.3 bits (64), Expect(2) = 3e-16
 Identities = 13/29 (44%), Positives = 19/29 (65%)
 Frame = -1

Query: 723 ILIIFAKLNAGIRYVQGMNEILAPLFFVF 637
           IL I+A  +    YVQG+N+++ P F VF
Sbjct: 285 ILFIWAIRHPASGYVQGINDLVTPFFVVF 313

>TB22A_MOUSE (Q8R5A6) TBC1 domain family member 22A|
          Length = 516

 Score = 73.9 bits (180), Expect(2) = 9e-16
 Identities = 45/131 (34%), Positives = 71/131 (54%), Gaps = 1/131 (0%)
 Frame = -2

Query: 593 EADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYDGELQHHLEITTEVNP 414
           EAD+++C  +LL G++DN+      +  GI+  +  L +L+ + D  +  HL+   EV  
Sbjct: 359 EADTYWCMSKLLDGIQDNYTF----AQPGIQMKVKMLEELVSRIDERVHRHLD-GHEVRY 413

Query: 413 QFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCAMLILVRKRLL-AGDF 237
             +AFRW+  LL +E     TI +WDT  S+P+G     L +C A L+  R+ +L   DF
Sbjct: 414 LQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLVRWRREILEERDF 473

Query: 236 TSNLKLLQSYP 204
              L  LQ+ P
Sbjct: 474 QELLLFLQNLP 484



 Score = 29.3 bits (64), Expect(2) = 9e-16
 Identities = 13/29 (44%), Positives = 19/29 (65%)
 Frame = -1

Query: 723 ILIIFAKLNAGIRYVQGMNEILAPLFFVF 637
           IL I+A  +    YVQG+N+++ P F VF
Sbjct: 304 ILFIWAIRHPASGYVQGINDLVTPFFVVF 332

>GYP1_YEAST (Q08484) GTPase-activating protein GYP1 (GAP for YPT1)|
          Length = 637

 Score = 61.6 bits (148), Expect(2) = 4e-11
 Identities = 33/91 (36%), Positives = 50/91 (54%)
 Frame = -2

Query: 593 EADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYDGELQHHLEITTEVNP 414
           EAD+F+C  +LL  + DN+     +   GI   +  L QL+K+ D +L +H +    V  
Sbjct: 422 EADTFWCLTKLLEQITDNYI----HGQPGILRQVKNLSQLVKRIDADLYNHFQ-NEHVEF 476

Query: 413 QFYAFRWITLLLTQEFNFADTIHIWDTLLSD 321
             +AFRW+  LL +EF     I +WDT LS+
Sbjct: 477 IQFAFRWMNCLLMREFQMGTVIRMWDTYLSE 507



 Score = 25.8 bits (55), Expect(2) = 4e-11
 Identities = 11/29 (37%), Positives = 18/29 (62%)
 Frame = -1

Query: 723 ILIIFAKLNAGIRYVQGMNEILAPLFFVF 637
           IL ++A  +    YVQG+N+++ P F  F
Sbjct: 363 ILYLWAIRHPASGYVQGINDLVTPFFETF 391

>TBCD5_HUMAN (Q92609) TBC1 domain family member 5|
          Length = 795

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 37/92 (40%), Positives = 52/92 (56%), Gaps = 1/92 (1%)
 Frame = -2

Query: 476 LLKKYDGELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETL 297
           LLKK+D EL  HL    E+ PQ Y  RW+ LL  +EF   D + +WD L +  DG    L
Sbjct: 308 LLKKHDIELYMHLN-RLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFA--DGLSLGL 364

Query: 296 L-RICCAMLILVRKRLLAGDFTSNLKLLQSYP 204
           +  I  AML+ +R  L++ ++ + L LL  YP
Sbjct: 365 VDYIFVAMLLYIRDALISSNYQTCLGLLMHYP 396



 Score = 33.1 bits (74), Expect = 0.89
 Identities = 14/33 (42%), Positives = 22/33 (66%)
 Frame = -1

Query: 726 NILIIFAKLNAGIRYVQGMNEILAPLFFVFRND 628
           ++L  +A+ N  + Y QGM+E+LAP+ FV   D
Sbjct: 188 DVLFCYARENEQLLYKQGMHELLAPIVFVLHCD 220

>TBCD5_MOUSE (Q80XQ2) TBC1 domain family member 5|
          Length = 815

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 34/91 (37%), Positives = 50/91 (54%)
 Frame = -2

Query: 476 LLKKYDGELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETL 297
           LLKK+D EL  HL    E+ PQ Y  RW+ LL  +EF   D + +WD L +D       +
Sbjct: 308 LLKKHDIELYMHLN-RLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADSLN-LSLV 365

Query: 296 LRICCAMLILVRKRLLAGDFTSNLKLLQSYP 204
             +  AML+ +R  L++ ++ + L LL  YP
Sbjct: 366 DYVFTAMLLYIRDALISSNYQTCLGLLMHYP 396



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 13/33 (39%), Positives = 21/33 (63%)
 Frame = -1

Query: 726 NILIIFAKLNAGIRYVQGMNEILAPLFFVFRND 628
           ++L  +A+ N  + Y QGM+E+LAP+ F    D
Sbjct: 188 DVLFCYARENEQLLYKQGMHELLAPIIFTLHCD 220

>TBC17_HUMAN (Q9HA65) TBC1 domain family member 17|
          Length = 648

 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 41/137 (29%), Positives = 69/137 (50%), Gaps = 1/137 (0%)
 Frame = -2

Query: 635 GMIQIIK-ILYGNFAEADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYD 459
           GM  ++  ILY    E D+F+CF   +  ++ NF    + S   ++  L +L+ LL+  D
Sbjct: 419 GMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNF----EESQETMKRQLGRLLLLLRVLD 474

Query: 458 GELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCA 279
             L   L+ + +     + FRW+ +   +EF F D + +W+ L +   GP   LL + CA
Sbjct: 475 PLLCDFLD-SQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLL-VACA 532

Query: 278 MLILVRKRLLAGDFTSN 228
           +L + R  L+   F SN
Sbjct: 533 ILDMERDTLMLSGFGSN 549



 Score = 34.7 bits (78), Expect = 0.31
 Identities = 14/44 (31%), Positives = 28/44 (63%)
 Frame = -1

Query: 726 NILIIFAKLNAGIRYVQGMNEILAPLFFVFRNDPDYKNSVWKLC 595
           +IL+ +   +  + YVQGM+++L+P+ +V +N+ D   + W  C
Sbjct: 402 DILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVD---AFWCFC 442

>TBC15_MOUSE (Q9CXF4) TBC1 domain family member 15|
          Length = 671

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 35/137 (25%), Positives = 72/137 (52%), Gaps = 1/137 (0%)
 Frame = -2

Query: 635 GMIQIIK-ILYGNFAEADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYD 459
           GM  ++  +LY    E D+F+CF   +  +  NF +++     G++  L +L  LL+  D
Sbjct: 438 GMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQ----GMKTQLIQLSTLLRLLD 493

Query: 458 GELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCA 279
                +LE + +    ++ FRW+ +   +EF+F D + +W+ + ++       LL +CCA
Sbjct: 494 SGFCSYLE-SQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELPCKNFHLL-LCCA 551

Query: 278 MLILVRKRLLAGDFTSN 228
           +L   +++++A  +  N
Sbjct: 552 ILESEKQQIMAKHYGFN 568



 Score = 33.5 bits (75), Expect = 0.68
 Identities = 13/35 (37%), Positives = 24/35 (68%)
 Frame = -1

Query: 726 NILIIFAKLNAGIRYVQGMNEILAPLFFVFRNDPD 622
           +IL+ +   +  + YVQGM+++L+PL +V  N+ D
Sbjct: 421 DILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVD 455

>TBC17_MOUSE (Q8BYH7) TBC1 domain family member 17|
          Length = 645

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 40/137 (29%), Positives = 68/137 (49%), Gaps = 1/137 (0%)
 Frame = -2

Query: 635 GMIQIIK-ILYGNFAEADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYD 459
           GM  ++  IL+    E D+F+CF   +  +  NF    + S   ++  L +L+ LL+  D
Sbjct: 419 GMSDLLSPILFVVQNEVDAFWCFCGFMELVHGNF----EESQETMKRQLGQLLLLLRVLD 474

Query: 458 GELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCA 279
             L   L+ + +     + FRW+ +   +EF F D + +W+ L +   GP   LL + CA
Sbjct: 475 QPLCDFLD-SQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLL-VACA 532

Query: 278 MLILVRKRLLAGDFTSN 228
           +L + R  L+   F SN
Sbjct: 533 ILDMERDTLMLSGFGSN 549



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 15/44 (34%), Positives = 28/44 (63%)
 Frame = -1

Query: 726 NILIIFAKLNAGIRYVQGMNEILAPLFFVFRNDPDYKNSVWKLC 595
           +IL+ +   +  + YVQGM+++L+P+ FV +N+ D   + W  C
Sbjct: 402 DILLTYCMYHFDLGYVQGMSDLLSPILFVVQNEVD---AFWCFC 442

>TBC15_HUMAN (Q8TC07) TBC1 domain family member 15|
          Length = 691

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 34/137 (24%), Positives = 70/137 (51%), Gaps = 1/137 (0%)
 Frame = -2

Query: 635 GMIQIIK-ILYGNFAEADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYD 459
           GM  ++  +LY    E D+F+CF   +  +  NF +++     G++  L +L  LL+  D
Sbjct: 455 GMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQ----GMKTQLIQLSTLLRLLD 510

Query: 458 GELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCA 279
                +LE + +    ++ FRW+ +   +EF F D + +W+ + ++       LL +CCA
Sbjct: 511 SGFCSYLE-SQDSGYLYFCFRWLLIRFKREFGFLDILRLWEVMWTELPCTNFHLL-LCCA 568

Query: 278 MLILVRKRLLAGDFTSN 228
           +L   +++++   +  N
Sbjct: 569 ILESEKQQIMEKHYGFN 585



 Score = 33.5 bits (75), Expect = 0.68
 Identities = 13/35 (37%), Positives = 24/35 (68%)
 Frame = -1

Query: 726 NILIIFAKLNAGIRYVQGMNEILAPLFFVFRNDPD 622
           +IL+ +   +  + YVQGM+++L+PL +V  N+ D
Sbjct: 438 DILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVD 472

>GYP7_CANGA (Q6FWI1) GTPase-activating protein GYP7 (GAP for YPT7)|
          Length = 745

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 29/106 (27%), Positives = 51/106 (48%), Gaps = 1/106 (0%)
 Frame = -2

Query: 635 GMIQIIKILYGNFAEADS-FFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYD 459
           GM  ++  LY    + ++ F+CF   +  +  NF +  D S  GIR  +  L  L +   
Sbjct: 522 GMTDLLSPLYYIIRDEETTFWCFTNFMERMERNFLR--DQS--GIRDQMLALTDLCQLML 577

Query: 458 GELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSD 321
             L  HL+   + +  F+ FR + +   +EFN+ D  +IW+   +D
Sbjct: 578 PRLSAHLQ-KCDSSDLFFCFRMLLVWFKREFNYDDIFNIWEVFFTD 622



 Score = 33.1 bits (74), Expect = 0.89
 Identities = 12/33 (36%), Positives = 23/33 (69%)
 Frame = -1

Query: 726 NILIIFAKLNAGIRYVQGMNEILAPLFFVFRND 628
           +IL  +   N  + YVQGM ++L+PL+++ R++
Sbjct: 505 DILTTYNIFNPNLGYVQGMTDLLSPLYYIIRDE 537

>GYP7_YEAST (P48365) GTPase-activating protein GYP7 (GAP for YPT7)|
          Length = 746

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 29/101 (28%), Positives = 48/101 (47%), Gaps = 1/101 (0%)
 Frame = -2

Query: 635 GMIQIIKILYGNFAEA-DSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYD 459
           GM  ++  +Y    E   +F+CF   +  +  NF +  D S  GI   +  L++L++   
Sbjct: 532 GMTDLLSPIYVIMKEEWKTFWCFTHFMDIMERNFLR--DQS--GIHEQMLTLVELVQLML 587

Query: 458 GELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWD 336
            EL  HL      N  F+ FR + +   +EF   D +HIW+
Sbjct: 588 PELSEHLNKCDSGN-LFFCFRMLLVWFKREFEMEDIMHIWE 627



 Score = 33.5 bits (75), Expect = 0.68
 Identities = 12/33 (36%), Positives = 22/33 (66%)
 Frame = -1

Query: 726 NILIIFAKLNAGIRYVQGMNEILAPLFFVFRND 628
           NILI +   N  + YVQGM ++L+P++ + + +
Sbjct: 515 NILITYNVYNTNLGYVQGMTDLLSPIYVIMKEE 547

>TBC16_HUMAN (Q8TBP0) TBC1 domain family member 16|
          Length = 767

 Score = 33.5 bits (75), Expect(2) = 0.003
 Identities = 27/93 (29%), Positives = 40/93 (43%), Gaps = 7/93 (7%)
 Frame = -2

Query: 593 EADSFFCFVELL------SGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYDGELQHHLEI 432
           E+D+F+CFV L+      S  RD   +K           L  L +LL+        HL  
Sbjct: 547 ESDTFWCFVGLMQNTIFVSSPRDEDMEK----------QLLYLRELLRLTHVRFYQHLVS 596

Query: 431 TTEVNPQF-YAFRWITLLLTQEFNFADTIHIWD 336
             E   Q  +  RW+ L   +EF  A+ + IW+
Sbjct: 597 LGEDGLQMLFCHRWLLLCFKREFPEAEALRIWE 629



 Score = 26.9 bits (58), Expect(2) = 0.003
 Identities = 11/34 (32%), Positives = 21/34 (61%)
 Frame = -1

Query: 723 ILIIFAKLNAGIRYVQGMNEILAPLFFVFRNDPD 622
           IL+ +A  N  + Y QGM++++AP+     ++ D
Sbjct: 516 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESD 549

>GYP7_DEBHA (Q6BU76) GTPase-activating protein GYP7 (GAP for YPT7)|
          Length = 757

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 28/106 (26%), Positives = 54/106 (50%), Gaps = 1/106 (0%)
 Frame = -2

Query: 635 GMIQIIKILYGNFA-EADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYD 459
           GM  ++  LY  F  E+ +F+ FV  +  +  NF +  D S  G++  +  L +L++   
Sbjct: 539 GMTDLLSPLYVTFQDESLTFWAFVNFMDRMERNFLR--DQS--GMKNQMLTLNELVQFML 594

Query: 458 GELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSD 321
            +L  HLE   E    ++ FR + +   +EF ++  + +W+ L +D
Sbjct: 595 PDLFKHLE-KCESTDLYFFFRMLLVWFKREFEWSSVLSLWEILWTD 639



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 12/32 (37%), Positives = 23/32 (71%)
 Frame = -1

Query: 723 ILIIFAKLNAGIRYVQGMNEILAPLFFVFRND 628
           IL+ + + N  + YVQGM ++L+PL+  F+++
Sbjct: 523 ILLTYNEHNVNLGYVQGMTDLLSPLYVTFQDE 554

>US6NL_MOUSE (Q80XC3) USP6 N-terminal-like protein|
          Length = 819

 Score = 37.7 bits (86), Expect = 0.036
 Identities = 32/141 (22%), Positives = 57/141 (40%)
 Frame = -2

Query: 635 GMIQIIKILYGNFAEADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYDG 456
           GM QI  +L     E D+F+  V+L SG +             +        ++L K+  
Sbjct: 188 GMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLS 247

Query: 455 ELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCAM 276
           +L+ HL+ + E+   FY  +W          F   + IWD  + +    +  L  +   +
Sbjct: 248 KLKQHLD-SQEIYTSFYTMKWFFQCFLDRTPFRLNLRIWDIYIFE---GERVLTAMSYTI 303

Query: 275 LILVRKRLLAGDFTSNLKLLQ 213
           L L +K L+       ++ LQ
Sbjct: 304 LKLHKKHLMKLSMEELVEFLQ 324

>US6NL_HUMAN (Q92738) USP6 N-terminal-like protein (Related to the N-terminus of|
           tre) (RN-tre)
          Length = 828

 Score = 37.4 bits (85), Expect = 0.047
 Identities = 30/129 (23%), Positives = 53/129 (41%)
 Frame = -2

Query: 635 GMIQIIKILYGNFAEADSFFCFVELLSGLRDNFCQKLDNSAVGIRGTLSKLMQLLKKYDG 456
           GM QI  +L     E D+F+  V+L SG +             +        ++L K+  
Sbjct: 188 GMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLS 247

Query: 455 ELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCAM 276
           +L+ HL+ + E+   FY  +W          F   + IWD  + +    +  L  +   +
Sbjct: 248 KLKQHLD-SQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFE---GERVLTAMSYTI 303

Query: 275 LILVRKRLL 249
           L L +K L+
Sbjct: 304 LKLHKKHLM 312

>TBC12_HUMAN (O60347) TBC1 domain family member 12|
          Length = 769

 Score = 37.4 bits (85), Expect = 0.047
 Identities = 40/153 (26%), Positives = 53/153 (34%), Gaps = 9/153 (5%)
 Frame = -2

Query: 635 GMIQIIKILYGNFAEADSFFCFVELLSGLRDNFCQKLDNSA---------VGIRGTLSKL 483
           GM  I  +L  N  EAD+F  F  LL+        ++D+S          V     LSKL
Sbjct: 584 GMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKL 643

Query: 482 MQLLKKYDGELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQE 303
               K Y             + P  Y   WI  L ++         +WD    D    +E
Sbjct: 644 FLHFKSYS------------LTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRD---GEE 688

Query: 302 TLLRICCAMLILVRKRLLAGDFTSNLKLLQSYP 204
            L R    +L L    LL  DF    + L   P
Sbjct: 689 FLFRTGLGILRLYEDILLQMDFIHIAQFLTKLP 721

>GYP7_YARLI (P09379) GTPase-activating protein GYP7 (GAP for YPT7)|
          Length = 730

 Score = 33.5 bits (75), Expect = 0.68
 Identities = 13/33 (39%), Positives = 25/33 (75%)
 Frame = -1

Query: 726 NILIIFAKLNAGIRYVQGMNEILAPLFFVFRND 628
           ++LI + + N  + YVQGM+++L+PL+ V ++D
Sbjct: 501 DMLITYNQHNKNLGYVQGMSDLLSPLYVVLQDD 533

>ERD2_SCHPO (O94270) ER lumen protein retaining receptor|
          Length = 212

 Score = 33.1 bits (74), Expect = 0.89
 Identities = 15/47 (31%), Positives = 31/47 (65%)
 Frame = -2

Query: 662 FWRHSSLYFGMIQIIKILYGNFAEADSFFCFVELLSGLRDNFCQKLD 522
           FWR+ SLY+ +++I+      F  ++S+ C++ L++ LR  + ++LD
Sbjct: 52  FWRYKSLYYFLMRIV------FIASESYICYLMLMT-LRPTYDKRLD 91

>CDC16_SCHPO (P36618) Cell division control protein 16|
          Length = 299

 Score = 32.0 bits (71), Expect = 2.0
 Identities = 39/167 (23%), Positives = 72/167 (43%), Gaps = 5/167 (2%)
 Frame = -2

Query: 659 WRHSSLYFGMIQIIK--ILYGNFAEADSFFCFVELLSGLRDNFCQKLDNSAV-GIRGTLS 489
           W+  +LY   + ++    LY   +E  +F  F  LL     N C       + G+     
Sbjct: 112 WKRGALYVQGMNVLASPFLYACKSENQAFQFFDRLLQ----NECPLYVLPNIDGVHRGAK 167

Query: 488 KLMQLLKKYDGELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGP 309
            L + L+  D  L  +L ++  +  + YA   I  L       ++ + IWD L +     
Sbjct: 168 LLDKCLEVLDHRLYTYL-LSKGLTAKIYALPSILTLSACTAPLSEALTIWDFLFA----- 221

Query: 308 QETLLRICC--AMLILVRKRLLAGDFTSNLKLLQSYPPTNIGHLLYV 174
               L I C  A + + R++L+  D  S + LL+++PP N  +++ +
Sbjct: 222 YGIHLNILCVIAQMFIFREQLI--DHPSPMTLLRTFPPLNAKNIMKI 266

>ASO_BRANA (Q00624) L-ascorbate oxidase homolog precursor (EC 1.10.3.3)|
           (Ascorbase)
          Length = 555

 Score = 31.6 bits (70), Expect = 2.6
 Identities = 23/94 (24%), Positives = 43/94 (45%)
 Frame = -2

Query: 488 KLMQLLKKYDGELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGP 309
           KL+    K DG+L+  L   +   P+        L L + F  +D +  +DT+  DP   
Sbjct: 356 KLVNTQGKVDGKLRFALNGVSHTEPE------TPLKLAEYFGISDKVFKYDTITDDPTPE 409

Query: 308 QETLLRICCAMLILVRKRLLAGDFTSNLKLLQSY 207
           Q   ++I   +L +  +  +   F ++ K +QS+
Sbjct: 410 QIKNIKIEPNVLNITHRTFVEVVFENHEKSVQSW 443

>AP3D_ASHGO (Q755A1) AP-3 complex subunit delta (Adapter-related protein|
           complex 3 delta subunit) (Delta-adaptin 3) (AP-3 complex
           delta subunit) (Delta-adaptin)
          Length = 899

 Score = 31.6 bits (70), Expect = 2.6
 Identities = 24/93 (25%), Positives = 43/93 (46%), Gaps = 18/93 (19%)
 Frame = +1

Query: 367 NSWVNSSVIHLNA*NW-------GLTSVVISKWC*-----SSPSYFFRSCINL------D 492
           ++W N SV+      W        L  ++ISK        S    F R C++       D
Sbjct: 550 SNWCNESVVDTGRIKWVTERIITPLEDLIISKNFEVQERSSEALEFLRLCLDSLSEDASD 609

Query: 493 SVPRIPTALLSSFWQKLSLRPLSNSTKQKKESA 591
           S+P + T +L SF+    L+P+++ T++K + +
Sbjct: 610 SLPLLLTEVLPSFFNAFELQPITSGTQRKLQQS 642

>TMEPA_MOUSE (Q9D7R2) Transmembrane prostate androgen-induced protein (NEDD4 WW|
           domain-binding protein 4)
          Length = 260

 Score = 30.4 bits (67), Expect = 5.8
 Identities = 24/76 (31%), Positives = 31/76 (40%), Gaps = 3/76 (3%)
 Frame = -1

Query: 393 DNTAVNPGIQLCRY---YSYMGHTVK*PRWSSGNLAENMLRNADPRPETAPCRRFHLQPQ 223
           D  AV P IQ  R+   Y Y+ H +  P   S +  E      +P P   PC      P+
Sbjct: 98  DRLAVPPFIQRSRFQPTYPYLQHEIALPPTISLSDGE------EPPPYQGPCTLQLRDPE 151

Query: 222 ASAELPSDEHRPPPLR 175
              EL  +  R PP R
Sbjct: 152 QQLELNRESVRAPPNR 167

>DNAA_STRRE (Q9ZH76) Chromosomal replication initiator protein dnaA|
          Length = 643

 Score = 30.4 bits (67), Expect = 5.8
 Identities = 14/37 (37%), Positives = 17/37 (45%)
 Frame = -1

Query: 291 NMLRNADPRPETAPCRRFHLQPQASAELPSDEHRPPP 181
           + L   +PRPE  P  R    P      PS+ HRP P
Sbjct: 131 DQLPGTEPRPEQLPSARPDQLPTVRPAYPSEYHRPEP 167

>GATA5_MOUSE (P97489) Transcription factor GATA-5 (GATA-binding factor 5)|
          Length = 404

 Score = 30.0 bits (66), Expect = 7.6
 Identities = 17/52 (32%), Positives = 22/52 (42%)
 Frame = -1

Query: 354 YYSYMGHTVK*PRWSSGNLAENMLRNADPRPETAPCRRFHLQPQASAELPSD 199
           Y +YM   V  P W+SG    ++L     RP   P RR    P    E P +
Sbjct: 142 YPAYMSSDVA-PSWTSGAFDSSILHGLQARPGGLPGRRTSFVPDFLEEFPGE 192

>TBC14_HUMAN (Q9P2M4) TBC1 domain family member 14|
          Length = 678

 Score = 30.0 bits (66), Expect = 7.6
 Identities = 37/153 (24%), Positives = 49/153 (32%), Gaps = 9/153 (5%)
 Frame = -2

Query: 635 GMIQIIKILYGNFAEADSFFCFVELLSGLRDNFCQKLDNSA---------VGIRGTLSKL 483
           GM  I  +L  N   AD+F  F  LL+        ++D+           V     L KL
Sbjct: 494 GMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKL 553

Query: 482 MQLLKKYDGELQHHLEITTEVNPQFYAFRWITLLLTQEFNFADTIHIWDTLLSDPDGPQE 303
               KK              + P  Y   WI  L ++         IWD    D    +E
Sbjct: 554 FAHFKK------------NNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRD---GEE 598

Query: 302 TLLRICCAMLILVRKRLLAGDFTSNLKLLQSYP 204
            L R    +L L    L   DF    + L   P
Sbjct: 599 FLFRTALGILKLFEDILTKMDFIHMAQFLTRLP 631

>ATG26_NEUCR (Q7S1I0) Sterol 3-beta-glucosyltransferase (EC 2.4.1.173)|
           (Autophagy-related protein 26)
          Length = 1553

 Score = 29.6 bits (65), Expect = 9.9
 Identities = 15/37 (40%), Positives = 19/37 (51%)
 Frame = -2

Query: 656 RHSSLYFGMIQIIKILYGNFAEADSFFCFVELLSGLR 546
           R  + YFG I  +  LYG    ++  FCF  LL G R
Sbjct: 847 RLQAAYFGFIVRVLPLYGKIYISNRHFCFRSLLPGTR 883

>BUB2_YEAST (P26448) Mitotic check point protein BUB2 (Cell cycle arrest|
           protein BUB2)
          Length = 306

 Score = 29.6 bits (65), Expect = 9.9
 Identities = 14/30 (46%), Positives = 18/30 (60%)
 Frame = -1

Query: 684 YVQGMNEILAPLFFVFRNDPDYKNSVWKLC 595
           YVQGMN +LAPL +   ++P       KLC
Sbjct: 130 YVQGMNVLLAPLLYSCPSEPMAYQLFTKLC 159

>NU5M_HIPAM (Q9ZZY1) NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3) (NADH|
           dehydrogenase subunit 5)
          Length = 594

 Score = 29.6 bits (65), Expect = 9.9
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 3/72 (4%)
 Frame = -2

Query: 407 YAFRW---ITLLLTQEFNFADTIHIWDTLLSDPDGPQETLLRICCAMLILVRKRLLAGDF 237
           Y+  W   ITL+ T       T  I+  LL  P  P  TL+     +L+   KRL+AG  
Sbjct: 403 YSNAWALLITLVATSLTAVYSTRIIFFALLGHPRFPTSTLIHENNPLLLNSLKRLMAGSI 462

Query: 236 TSNLKLLQSYPP 201
            +   L  + PP
Sbjct: 463 FAGFILSHNLPP 474


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,369,803
Number of Sequences: 219361
Number of extensions: 2073395
Number of successful extensions: 5379
Number of sequences better than 10.0: 33
Number of HSP's better than 10.0 without gapping: 5195
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5361
length of database: 80,573,946
effective HSP length: 109
effective length of database: 56,663,597
effective search space used: 7479594804
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)