>CAS1_ARATH (P38605) Cycloartenol synthase (EC 5.4.99.8)|
            (2,3-epoxysqualene--cycloartenol cyclase)
          Length = 759

 Score =  155 bits (393), Expect(2) = 5e-42
 Identities = 80/141 (56%), Positives = 100/141 (70%), Gaps = 2/141 (1%)
 Frame = -2

Query: 639  GAFFAVKGLAASGRTYDNSDCMRKSCEFLLSKQQSTGGWGESYLSIETEEY--VDSGSSH 466
            G +F VKGL A G+T  NS  + K+CEFLLSKQQ +GGWGESYLS + + Y  +D   SH
Sbjct: 617  GTWFGVKGLVAVGKTLKNSPHVAKACEFLLSKQQPSGGWGESYLSCQDKVYSNLDGNRSH 676

Query: 465  AVATAWAMLALIYAGQAEIYPVPLYRAAKLLMNMQLDSGEFPQQEHMGCANSAFFFNYPN 286
             V TAWAMLALI AGQAE+   PL+RAA+ L+N Q+++G+FPQQE MG  N      Y  
Sbjct: 677  VVNTAWAMLALIGAGQAEVDRKPLHRAARYLINAQMENGDFPQQEIMGVFNRNCMITYAA 736

Query: 285  YRNIFPIMALGEFRRRLIENQ 223
            YRNIFPI ALGE+R +++  Q
Sbjct: 737  YRNIFPIWALGEYRCQVLLQQ 757



 Score = 35.4 bits (80), Expect(2) = 5e-42
 Identities = 11/17 (64%), Positives = 14/17 (82%)
 Frame = -1

Query: 691 QRKNGSWYGTWGICFTY 641
           Q  +GSWYG+W +CFTY
Sbjct: 600 QAADGSWYGSWAVCFTY 616

>ERG7_YEAST (P38604) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 730

 Score =  108 bits (269), Expect = 2e-23
 Identities = 60/132 (45%), Positives = 78/132 (59%), Gaps = 2/132 (1%)
 Frame = -2

Query: 630 FAVKGLAASGRTYDNSDCMRKSCEFLLSKQQSTGGWGESYLSIETEEYVDSGSSHAVATA 451
           FA++ L   G TY+NS  +RK C+FL+SKQ   GGWGES  S E   YVDS  S  V TA
Sbjct: 596 FALEALHTVGETYENSSTVRKGCDFLVSKQMKDGGWGESMKSSELHSYVDSEKSLVVQTA 655

Query: 450 WAMLALIYAGQAEIYP--VPLYRAAKLLMNMQLDSGEFPQQEHMGCANSAFFFNYPNYRN 277
           WA++AL++A     YP    + R   LL N Q +SGE+  +   G  N +    YP+YR 
Sbjct: 656 WALIALLFAE----YPNKEVIDRGIDLLKNRQEESGEWKFESVEGVFNHSCAIEYPSYRF 711

Query: 276 IFPIMALGEFRR 241
           +FPI ALG + R
Sbjct: 712 LFPIKALGMYSR 723



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 16/31 (51%), Positives = 20/31 (64%)
 Frame = -1

Query: 691 QRKNGSWYGTWGICFTYRGLLCGERFSCFGK 599
           Q  +GSWYG+WGICFTY G+   E     G+
Sbjct: 576 QLPDGSWYGSWGICFTYAGMFALEALHTVGE 606

>ERG7_PNECA (Q96WJ0) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 719

 Score = 84.3 bits (207), Expect(2) = 6e-22
 Identities = 47/132 (35%), Positives = 71/132 (53%), Gaps = 1/132 (0%)
 Frame = -2

Query: 630 FAVKGLAASGRTYDNSDCMRKSCEFLLSKQQSTGGWGESYLSIETEEYV-DSGSSHAVAT 454
           FA++ L+     Y+NS   R++C+FL++KQ+  GGW E Y S     +      S  V T
Sbjct: 586 FALESLSCVKDFYENSFHSRRACDFLVNKQEEDGGWSEGYQSCTDGIWTRHPTGSQVVQT 645

Query: 453 AWAMLALIYAGQAEIYPVPLYRAAKLLMNMQLDSGEFPQQEHMGCANSAFFFNYPNYRNI 274
           AWA + L+YA   +    P+ R   L+M+ Q  +GE+ Q+   G  N     +YPNY+  
Sbjct: 646 AWACIGLMYANYPD--ETPIKRGINLIMSRQQPNGEWKQEAIEGVFNKNCMISYPNYKFN 703

Query: 273 FPIMALGEFRRR 238
           F I ALG + +R
Sbjct: 704 FTIKALGMYSKR 715



 Score = 39.7 bits (91), Expect(2) = 6e-22
 Identities = 15/28 (53%), Positives = 18/28 (64%)
 Frame = -1

Query: 691 QRKNGSWYGTWGICFTYRGLLCGERFSC 608
           QR +GSWY +W ICFTY  +   E  SC
Sbjct: 566 QRPDGSWYESWAICFTYATMFALESLSC 593

>ERG7_RAT (P48450) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 733

 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 51/134 (38%), Positives = 72/134 (53%), Gaps = 3/134 (2%)
 Frame = -2

Query: 639 GAFFAVKGLAASGRTYDNSDC---MRKSCEFLLSKQQSTGGWGESYLSIETEEYVDSGSS 469
           G +F ++  A  G  Y N      + ++C FLLS+Q + GGWGE + S E   YV S  S
Sbjct: 589 GTWFGLEAFACMGHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGS 648

Query: 468 HAVATAWAMLALIYAGQAEIYPVPLYRAAKLLMNMQLDSGEFPQQEHMGCANSAFFFNYP 289
              +T WA+L L+     +I      R  + L+  QL +G++PQ+   G  N +   +Y 
Sbjct: 649 QVHSTCWALLGLMAVRHPDISAQE--RGIRCLLGKQLPNGDWPQENISGVFNKSCAISYT 706

Query: 288 NYRNIFPIMALGEF 247
           NYRNIFPI ALG F
Sbjct: 707 NYRNIFPIWALGRF 720



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 16/30 (53%), Positives = 20/30 (66%)
 Frame = -1

Query: 691 QRKNGSWYGTWGICFTYRGLLCGERFSCFG 602
           QR +GSW G+WG+CFTY      E F+C G
Sbjct: 572 QRADGSWEGSWGVCFTYGTWFGLEAFACMG 601

>ERG7_SCHPO (Q10231) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 721

 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 55/135 (40%), Positives = 74/135 (54%), Gaps = 2/135 (1%)
 Frame = -2

Query: 636 AFFAVKGLAASGRTYDNSDCMRKSCEFLLSKQQSTGGWGESYLSIETEEYVDSGSSHAVA 457
           A FA   LA++GR Y+N    +K+CEFLLSKQ+  GGW ESY++  T  Y ++ SS    
Sbjct: 584 AMFATGSLASAGRYYENCPVQKKACEFLLSKQRPDGGWSESYMACVTGVYTETESSLVTQ 643

Query: 456 TAWAMLALIYAGQAEIYP--VPLYRAAKLLMNMQLDSGEFPQQEHMGCANSAFFFNYPNY 283
           T WA+ ALI A     YP   P+ +  K LM  Q   G + Q+   G  N      YPNY
Sbjct: 644 TGWALDALINAK----YPDRKPIEKGIKFLMASQKSDGSWQQKSMEGIFNKNVAIAYPNY 699

Query: 282 RNIFPIMALGEFRRR 238
           +  F I  LG+F ++
Sbjct: 700 KLYFSIYTLGKFAKQ 714



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 14/31 (45%), Positives = 19/31 (61%)
 Frame = -1

Query: 691 QRKNGSWYGTWGICFTYRGLLCGERFSCFGK 599
           QR +GSWYG+W ICFTY  +      +  G+
Sbjct: 566 QRPDGSWYGSWAICFTYAAMFATGSLASAGR 596

>ERG7_CANAL (Q04782) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 728

 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 49/133 (36%), Positives = 76/133 (57%)
 Frame = -2

Query: 636 AFFAVKGLAASGRTYDNSDCMRKSCEFLLSKQQSTGGWGESYLSIETEEYVDSGSSHAVA 457
           + FA++ L   G  Y++S  ++K C+FL+SKQ   GGW ES    ET  YV+  +S  V 
Sbjct: 591 SMFALEALHTVGLDYESSSAVKKGCDFLISKQLPDGGWSESMKGCETHSYVNGENSLVVQ 650

Query: 456 TAWAMLALIYAGQAEIYPVPLYRAAKLLMNMQLDSGEFPQQEHMGCANSAFFFNYPNYRN 277
           +AWA++ LI     +    P+ R  + LM  QL +GE+  ++  G  N +    YP+YR 
Sbjct: 651 SAWALIGLILGNYPD--EEPIKRGIQFLMKRQLPTGEWKYEDIEGVFNHSCAIEYPSYRF 708

Query: 276 IFPIMALGEFRRR 238
           +FPI ALG ++ +
Sbjct: 709 LFPIKALGLYKNK 721



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 14/29 (48%), Positives = 17/29 (58%)
 Frame = -1

Query: 682 NGSWYGTWGICFTYRGLLCGERFSCFGKD 596
           +GSWYG WGIC+TY  +   E     G D
Sbjct: 576 DGSWYGCWGICYTYASMFALEALHTVGLD 604

>ERG7_HUMAN (P48449) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 732

 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 51/134 (38%), Positives = 76/134 (56%), Gaps = 3/134 (2%)
 Frame = -2

Query: 639 GAFFAVKGLAASGRTY-DNSDC--MRKSCEFLLSKQQSTGGWGESYLSIETEEYVDSGSS 469
           G +F ++  A  G+TY D + C  + ++C+FLLS+Q + GGWGE + S E   Y+ S  S
Sbjct: 588 GTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQS 647

Query: 468 HAVATAWAMLALIYAGQAEIYPVPLYRAAKLLMNMQLDSGEFPQQEHMGCANSAFFFNYP 289
               T WAM+ L+     +I      R  + L+  QL +G++PQ+   G  N +   +Y 
Sbjct: 648 QIHNTCWAMMGLMAVRHPDIEAQE--RGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYT 705

Query: 288 NYRNIFPIMALGEF 247
           +YRNIFPI ALG F
Sbjct: 706 SYRNIFPIWALGRF 719



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 16/31 (51%), Positives = 21/31 (67%)
 Frame = -1

Query: 691 QRKNGSWYGTWGICFTYRGLLCGERFSCFGK 599
           QR +GSW G+WG+CFTY      E F+C G+
Sbjct: 571 QRADGSWEGSWGVCFTYGTWFGLEAFACMGQ 601

>ERG7_MOUSE (Q8BLN5) Lanosterol synthase (EC 5.4.99.7) (Oxidosqualene--lanosterol|
            cyclase) (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 733

 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 52/141 (36%), Positives = 77/141 (54%), Gaps = 3/141 (2%)
 Frame = -2

Query: 639  GAFFAVKGLAASGRTY-DNSDC--MRKSCEFLLSKQQSTGGWGESYLSIETEEYVDSGSS 469
            G +F ++  A  G TY D + C  + ++C FLLS+Q + GGWGE + S E   YV S  S
Sbjct: 589  GTWFGLEAFACMGHTYQDGAACAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARS 648

Query: 468  HAVATAWAMLALIYAGQAEIYPVPLYRAAKLLMNMQLDSGEFPQQEHMGCANSAFFFNYP 289
               +T WA++ L+     +I      R  + L+  QL +G++PQ+   G  N +   +Y 
Sbjct: 649  QVHSTCWALMGLMAVRHPDI--TAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYT 706

Query: 288  NYRNIFPIMALGEFRRRLIEN 226
            +YRNIFPI ALG F     +N
Sbjct: 707  SYRNIFPIWALGRFSNLYPDN 727



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 16/30 (53%), Positives = 20/30 (66%)
 Frame = -1

Query: 691 QRKNGSWYGTWGICFTYRGLLCGERFSCFG 602
           QR +GSW G+WG+CFTY      E F+C G
Sbjct: 572 QRADGSWEGSWGVCFTYGTWFGLEAFACMG 601

>SQHC_ALIAC (P33247) Squalene--hopene cyclase (EC 5.4.99.17)|
          Length = 630

 Score = 65.5 bits (158), Expect(2) = 5e-13
 Identities = 36/115 (31%), Positives = 59/115 (51%), Gaps = 1/115 (0%)
 Frame = -2

Query: 576 MRKSCEFLLSKQQSTGGWGESYLSIETEEYVDSGSSHAVATAWAMLALIYAGQAEIYPVP 397
           ++K+ +++   Q   GGWGE   S E   Y   G+S    TAWA++ALI  G+AE     
Sbjct: 515 IQKALDWVEQHQNPDGGWGEDCRSYEDPAYAGKGASTPSQTAWALMALIAGGRAE--SEA 572

Query: 396 LYRAAKLLMNMQLDSGEFPQQEHMGCA-NSAFFFNYPNYRNIFPIMALGEFRRRL 235
             R  + L+  Q   G + +  + G      F+  Y  YR++FP +ALG +++ +
Sbjct: 573 ARRGVQYLVETQRPDGGWDEPYYTGTGFPGDFYLGYTMYRHVFPTLALGRYKQAI 627



 Score = 28.5 bits (62), Expect(2) = 5e-13
 Identities = 8/17 (47%), Positives = 13/17 (76%)
 Frame = -1

Query: 691 QRKNGSWYGTWGICFTY 641
           Q+ +GSW+G WG+ + Y
Sbjct: 478 QKPDGSWFGRWGVNYLY 494

>SQHC_RHISN (P55348) Probable squalene--hopene cyclase (EC 5.4.99.17)|
          Length = 647

 Score = 62.0 bits (149), Expect(2) = 5e-12
 Identities = 44/135 (32%), Positives = 68/135 (50%), Gaps = 3/135 (2%)
 Frame = -2

Query: 639 GAFFAVKGLAASGRTYDNSDCM-RKSCEFLLSKQQSTGGWGESYLSIETE-EYVDSGSSH 466
           G +  +  L A+G   D+ D M RK+ E+L+S Q   GGWGE  +S   +    +   S 
Sbjct: 510 GTWSVLCALNAAG--IDHQDPMIRKAVEWLVSIQSWDGGWGEDAISYRLDYSGYEQAPST 567

Query: 465 AVATAWAMLALIYAGQAEIYPVPLYRAAKLLMNMQLDSGEFPQQEHMGCA-NSAFFFNYP 289
           +  TAWA+L L+ AG+ E +P  + R    L N Q ++G + +Q +        F+  Y 
Sbjct: 568 SSQTAWALLGLMAAGEVE-HPA-VARGVNYLKNAQTENGLWDEQRYTATGFPRVFYLRYH 625

Query: 288 NYRNIFPIMALGEFR 244
            Y   FP+ AL  +R
Sbjct: 626 GYSKFFPLWALARYR 640



 Score = 28.5 bits (62), Expect(2) = 5e-12
 Identities = 9/17 (52%), Positives = 11/17 (64%)
 Frame = -1

Query: 691 QRKNGSWYGTWGICFTY 641
           Q   GSWYG WG+ + Y
Sbjct: 493 QHAEGSWYGRWGLNYIY 509

>SQHC_BRAJA (P54924) Squalene--hopene cyclase (EC 5.4.99.17)|
          Length = 660

 Score = 58.9 bits (141), Expect(2) = 2e-11
 Identities = 40/134 (29%), Positives = 69/134 (51%), Gaps = 2/134 (1%)
 Frame = -2

Query: 639 GAFFAVKGLAASGRTYDNSDCMRKSCEFLLSKQQSTGGWGESYLSIETE-EYVDSGSSHA 463
           G +  +  L  +G  +D+   +RK+ ++L S Q   GGWGE  +S   + +  ++  S A
Sbjct: 516 GTWSVLCALNMAGVRHDDP-MIRKAADWLASIQNKDGGWGEDAVSYRLDYKGWEAAPSTA 574

Query: 462 VATAWAMLALIYAGQAEIYPVPLYRAAKLLMNMQLDSGEFPQQEHMGCA-NSAFFFNYPN 286
             TAWA+LAL+ AG+ + +P  + R  + L+  Q + G + +Q +        F+  Y  
Sbjct: 575 SQTAWALLALMAAGEVD-HPA-VARGVEYLIATQNEKGLWDEQRYTATGFPRVFYLRYHG 632

Query: 285 YRNIFPIMALGEFR 244
           Y   FP+ AL  +R
Sbjct: 633 YSKFFPLWALARYR 646



 Score = 29.3 bits (64), Expect(2) = 2e-11
 Identities = 10/17 (58%), Positives = 11/17 (64%)
 Frame = -1

Query: 691 QRKNGSWYGTWGICFTY 641
           Q   GSWYG WG+ F Y
Sbjct: 499 QHPEGSWYGRWGMNFIY 515

>SQHC_ZYMMO (P33990) Squalene--hopene cyclase (EC 5.4.99.17)|
          Length = 658

 Score = 47.0 bits (110), Expect(2) = 1e-07
 Identities = 42/144 (29%), Positives = 65/144 (45%), Gaps = 5/144 (3%)
 Frame = -2

Query: 639 GAFFAVKGLAASGRTYDNSDCMRKSCEFLLSKQQSTGGWGE---SY-LSIETEEYVDSGS 472
           G + A+  L  +   +D+   ++K+  +L + Q   GGWGE   SY L     E +DS +
Sbjct: 514 GTWSALCALNVAALPHDHL-AIQKAVAWLKTIQNEDGGWGENCDSYALDYSGYEPMDSTA 572

Query: 471 SHAVATAWAMLALIYAGQAEIYPVPLYRAAKLLMNMQLDSGEFPQQEHMGCA-NSAFFFN 295
           S    TAWA+L L+  G+A    V   +    L   Q + G + +  + G      F+  
Sbjct: 573 SQ---TAWALLGLMAVGEANSEAVT--KGINWLAQNQDEEGLWKEDYYSGGGFPRVFYLR 627

Query: 294 YPNYRNIFPIMALGEFRRRLIENQ 223
           Y  Y   FP+ AL  +R     NQ
Sbjct: 628 YHGYSKYFPLWALARYRNLKKANQ 651



 Score = 28.5 bits (62), Expect(2) = 1e-07
 Identities = 8/17 (47%), Positives = 13/17 (76%)
 Frame = -1

Query: 691 QRKNGSWYGTWGICFTY 641
           Q ++GSW+G WG+ + Y
Sbjct: 497 QEEDGSWFGRWGVNYIY 513

>HOG3_HORVU (P80198) Gamma-hordein-3|
          Length = 289

 Score = 31.6 bits (70), Expect = 2.4
 Identities = 23/86 (26%), Positives = 39/86 (45%)
 Frame = +3

Query: 423 QHKSMQALPMQWPLHENYRCPHTPRFQWKDSFRPIHLYSVVWTIKIHMISSYNHYYHKSF 602
           Q +  Q  P Q PL +    P  P+   +  F P  L    +  ++ +         + F
Sbjct: 36  QQEPEQPYPQQQPLPQQQPFPQQPQLPHQHQF-PQQLPQQQFPQQMPLQPQ------QQF 88

Query: 603 PKQLNLSPQRRPR*VKQIPQVPYQEP 680
           P+Q+ L PQ++P+  +Q P   YQ+P
Sbjct: 89  PQQMPLQPQQQPQFPQQKPFGQYQQP 114

>IMDH1_ARATH (P47996) Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (IMP|
           dehydrogenase) (IMPDH) (IMPD)
          Length = 503

 Score = 29.6 bits (65), Expect = 9.1
 Identities = 24/84 (28%), Positives = 38/84 (45%)
 Frame = -2

Query: 681 MVLGMALGVFVSLTGAFFAVKGLAASGRTYDNSDCMRKSCEFLLSKQQSTGGWGESYLSI 502
           +V  + LG    + G+F A    A  G  Y N   ++K    + S +  T G  + YL  
Sbjct: 364 IVKALVLGASTVMMGSFLAGSTEAPGGYEYTNGKRIKK-YRGMGSLEAMTKGSDQRYLGD 422

Query: 501 ETEEYVDSGSSHAVATAWAMLALI 430
           +T+  +  G   AVA   ++L LI
Sbjct: 423 QTKLKIAQGVVGAVADKGSVLKLI 446


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,459,855
Number of Sequences: 219361
Number of extensions: 2035967
Number of successful extensions: 5223
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 5005
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5206
length of database: 80,573,946
effective HSP length: 108
effective length of database: 56,882,958
effective search space used: 6882837918
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)