ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | rbasd14l01 |
|---|---|
| Clone Library Name | barley_pub |
>C72A1_CATRO (Q05047) Cytochrome P450 72A1 (EC 1.3.3.9) (CYPLXXII) (Secologanin| synthase) (SLS) Length = 524 Score = 99.0 bits (245), Expect(2) = 4e-30 Identities = 47/84 (55%), Positives = 61/84 (72%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 +FNPMRF +GVA A K L FS GPR C+GQNFA+L+AK +A +LQ+F F ++PSY Sbjct: 440 EFNPMRFVDGVANATKNNVTYLPFSWGPRVCLGQNFALLQAKLGLAMILQRFKFDVAPSY 499 Query: 246 VHAPADFLTLQPKFGLPVVMKLLD 175 VHAP LT+QP+FG V+ K L+ Sbjct: 500 VHAPFTILTVQPQFGSHVIYKKLE 523 Score = 52.4 bits (124), Expect(2) = 4e-30 Identities = 22/62 (35%), Positives = 37/62 (59%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 ++M+L+E LRLY P + + + D +G+ TIP +++ +HR+K +WGEDA Sbjct: 382 VSMILYEVLRLYPPVIDLTKIVHKDTKLGSYTIPAGTQVMLPTVMLHREKSIWGEDAMEF 441 Query: 421 QP 416 P Sbjct: 442 NP 443
>CP4S3_DROME (Q9VXY0) Probable cytochrome P450 4s3 (EC 1.14.-.-) (CYPIVS3)| Length = 495 Score = 53.9 bits (128), Expect(2) = 3e-13 Identities = 33/84 (39%), Positives = 45/84 (53%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 ++F+P RF V P A AFS GPR CIGQ FAMLE K+ +A +L+ + F P Sbjct: 407 ERFDPDRFL--VNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFL--PD 462 Query: 249 YVHAPADFLTLQPKFGLPVVMKLL 178 H P L K G + +++L Sbjct: 463 KDHQPKPLAELVTKSGNGIRLRIL 486 Score = 40.4 bits (93), Expect(2) = 3e-13 Identities = 20/48 (41%), Positives = 27/48 (56%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKK 449 V+ ETLR+Y F RK D+ VG +T+PK +I +HRD K Sbjct: 354 VIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPK 401
>CPXB_BACME (P14779) Bifunctional P-450:NADPH-P450 reductase (Cytochrome| P450(BM-3)) (P450BM-3) [Includes: Cytochrome P450 102 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)] Length = 1048 Score = 48.1 bits (113), Expect(2) = 8e-12 Identities = 30/75 (40%), Positives = 41/75 (54%), Gaps = 1/75 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVP-HALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 ++F P RF N A +P HA F G RACIGQ FA+ EA V+ +L+ F F Sbjct: 372 EEFRPERFENPSA----IPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHT 427 Query: 252 SYVHAPADFLTLQPK 208 +Y + LTL+P+ Sbjct: 428 NYELDIKETLTLKPE 442 Score = 41.2 bits (95), Expect(2) = 8e-12 Identities = 22/63 (34%), Positives = 36/63 (57%), Gaps = 2/63 (3%) Frame = -3 Query: 595 MVLHETLRLY--GPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 MVL+E LRL+ PA + K T ++ G + K +++ P +HRDK +WG+D Sbjct: 316 MVLNEALRLWPTAPAFSLYAKEDT-VLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEF 374 Query: 421 QPD 413 +P+ Sbjct: 375 RPE 377
>CP3A5_HUMAN (P20815) Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (P450-PCN3)| (HLp2) Length = 502 Score = 43.5 bits (101), Expect(2) = 9e-11 Identities = 23/66 (34%), Positives = 36/66 (54%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++ETLRL+ A+ ++R D+ + + IPK +VI +H D K W E Sbjct: 356 LDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTE----- 410 Query: 421 QPDEVR 404 P+E R Sbjct: 411 -PEEFR 415 Score = 42.4 bits (98), Expect(2) = 9e-11 Identities = 21/55 (38%), Positives = 30/55 (54%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F P RF+ + + P+ F GPR CIG FA++ K + VLQ FSF Sbjct: 412 EEFRPERFSK--KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464
>CP134_DROME (Q9VG40) Probable cytochrome P450 313a4 (EC 1.14.-.-)| (CYPCCCXIIIA4) Length = 478 Score = 48.9 bits (115), Expect(2) = 1e-10 Identities = 23/64 (35%), Positives = 38/64 (59%), Gaps = 1/64 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVG-AITIPKEHAIVIGAPFMHRDKKVWGEDAGS 425 + ++L+E++R+ P + R+T+ D+ + I +PK I I MHR KK+WG DA + Sbjct: 336 LDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAET 395 Query: 424 VQPD 413 PD Sbjct: 396 FNPD 399 Score = 36.2 bits (82), Expect(2) = 1e-10 Identities = 20/58 (34%), Positives = 32/58 (55%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 256 + FNP F + K P+A + F+ G R CIG +A++ AK +A +L+ + F S Sbjct: 394 ETFNPDHFLPHNIQD-KHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTS 450
>CP3AF_CAVPO (Q64406) Cytochrome P450 3A15 (EC 1.14.14.1) (CYPIIIA15)| Length = 503 Score = 44.3 bits (103), Expect(2) = 2e-10 Identities = 24/66 (36%), Positives = 37/66 (56%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++ETLRLY A ++R + D + ++ PK ++I + +HRD K W E Sbjct: 356 LDMVVNETLRLYPVANRIERMSKKDFEINGMSFPKGTLVMIPSFALHRDSKYWPE----- 410 Query: 421 QPDEVR 404 PDE R Sbjct: 411 -PDEFR 415 Score = 40.0 bits (92), Expect(2) = 2e-10 Identities = 20/55 (36%), Positives = 29/55 (52%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 D+F P RF+ P+ + F GPR CIG+ A++ K + +LQ FSF Sbjct: 412 DEFRPERFSKKNKENID-PYIYMPFGNGPRNCIGRRMALMNLKLALIRLLQNFSF 465
>CP3AH_CAVPO (Q64409) Cytochrome P450 3A17 (EC 1.14.14.1) (CYPIIIA17)| Length = 503 Score = 43.1 bits (100), Expect(2) = 7e-10 Identities = 23/66 (34%), Positives = 36/66 (54%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++ETLRLY ++R + D + ++ PK ++I + +HRD K W E Sbjct: 356 LDMVVNETLRLYPVTNRIERMSKKDFEINGMSFPKGTGVMIPSFALHRDSKYWPE----- 410 Query: 421 QPDEVR 404 PDE R Sbjct: 411 -PDEFR 415 Score = 39.7 bits (91), Expect(2) = 7e-10 Identities = 20/55 (36%), Positives = 28/55 (50%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 D+F P RF+ P+ + F GPR CIG A++ K + +LQ FSF Sbjct: 412 DEFRPERFSKKNKENID-PYIYMPFGNGPRNCIGMRMALMNLKLALIRLLQNFSF 465
>CP3AE_CAVPO (Q64417) Cytochrome P450 3A14 (EC 1.14.14.1) (CYPIIIA14)| Length = 503 Score = 43.1 bits (100), Expect(2) = 7e-10 Identities = 23/66 (34%), Positives = 36/66 (54%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++ETLRLY ++R + D + ++ PK ++I + +HRD K W E Sbjct: 356 LDMVVNETLRLYPVTNRIERMSKKDFEINGMSFPKGTGVMIPSFALHRDSKYWPE----- 410 Query: 421 QPDEVR 404 PDE R Sbjct: 411 -PDEFR 415 Score = 39.7 bits (91), Expect(2) = 7e-10 Identities = 20/55 (36%), Positives = 28/55 (50%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 D+F P RF+ P+ + F GPR CIG A++ K + +LQ FSF Sbjct: 412 DEFRPERFSKKNKENID-PYIYMPFGNGPRNCIGMRMALMNLKLALIRLLQNFSF 465
>CP4F5_RAT (P51870) Cytochrome P450 4F5 (EC 1.14.14.1) (CYPIVF5)| Length = 526 Score = 45.1 bits (105), Expect(2) = 1e-09 Identities = 24/51 (47%), Positives = 31/51 (60%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 F+P RF + R + P + + FS GPR CIGQ FAM E K V+A L +F Sbjct: 442 FDPFRF-DSENRQKRSPLSFIPFSAGPRNCIGQTFAMNEMKVVVALTLLRF 491 Score = 37.0 bits (84), Expect(2) = 1e-09 Identities = 20/54 (37%), Positives = 32/54 (59%), Gaps = 1/54 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVW 443 +TM + E+LRL+ PA+ + R+ T D+V+ IPK + VI +H + VW Sbjct: 383 LTMCIKESLRLHPPAIDLLRRCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVW 436
>CP4AB_HUMAN (Q02928) Cytochrome P450 4A11 precursor (EC 1.14.15.3) (CYPIVA11)| (Fatty acid omega-hydroxylase) (P-450 HK omega) (Lauric acid omega-hydroxylase) (CYP4AII) (P450-HL-omega) Length = 519 Score = 52.4 bits (124), Expect(2) = 1e-09 Identities = 32/82 (39%), Positives = 44/82 (53%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RFA G A+ + HA L FS G R CIG+ FAM E K A L +F P+ + Sbjct: 431 FDPFRFAPGSAQHS---HAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRI 487 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 P L L+ K G+ + ++ L Sbjct: 488 PIPIARLVLKSKNGIHLRLRRL 509 Score = 29.6 bits (65), Expect(2) = 1e-09 Identities = 16/53 (30%), Positives = 28/53 (52%), Gaps = 1/53 (1%) Frame = -3 Query: 598 TMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVW 443 TM + E LRLY P + R+ +T + ++PK +++ +H + KVW Sbjct: 373 TMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVW 425
>CP4CU_BLAGE (Q964T1) Cytochrome P450 4c21 (EC 1.14.14.1) (CYPIVC21)| Length = 501 Score = 46.2 bits (108), Expect(2) = 1e-09 Identities = 24/55 (43%), Positives = 33/55 (60%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 D F P R N + P+A + FS GPR CIGQ FA+LE K V++ +L+ + F Sbjct: 422 DNFLPDRVVN------RHPYAYIPFSAGPRNCIGQRFALLEEKVVLSYLLRHYRF 470 Score = 35.8 bits (81), Expect(2) = 1e-09 Identities = 16/50 (32%), Positives = 28/50 (56%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+ E+LRL+ ++ R+ D +G TIP I PF+HR+ +++ Sbjct: 364 VIKESLRLHPSVIYFVREAHQDFELGGYTIPAGTNIDFSVPFIHRNPEIF 413
>CP3A3_HUMAN (P05184) Cytochrome P450 3A3 (EC 1.14.14.1) (CYPIIIA3) (HLp)| Length = 503 Score = 42.7 bits (99), Expect(2) = 1e-09 Identities = 20/55 (36%), Positives = 34/55 (61%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 + MV++ETLRL+ A+ ++R D+ + + IPK ++I + +HRD K W E Sbjct: 356 LDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTE 410 Score = 38.9 bits (89), Expect(2) = 1e-09 Identities = 17/37 (45%), Positives = 21/37 (56%) Frame = -1 Query: 375 PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 P+ F GPR CIG FA++ K + VLQ FSF Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 465
>CP3A4_HUMAN (P08684) Cytochrome P450 3A4 (EC 1.14.13.67) (Quinine| 3-monooxygenase) (CYPIIIA4) (Nifedipine oxidase) (Taurochenodeoxycholate 6-alpha-hydroxylase) (EC 1.14.13.97) (NF-25) (P450-PCN1) Length = 502 Score = 42.7 bits (99), Expect(2) = 1e-09 Identities = 20/55 (36%), Positives = 34/55 (61%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 + MV++ETLRL+ A+ ++R D+ + + IPK ++I + +HRD K W E Sbjct: 355 LDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTE 409 Score = 38.9 bits (89), Expect(2) = 1e-09 Identities = 17/37 (45%), Positives = 21/37 (56%) Frame = -1 Query: 375 PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 P+ F GPR CIG FA++ K + VLQ FSF Sbjct: 428 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 464
>CP4B1_RAT (P15129) Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (P450-isozyme| 5) (P450 L-2) Length = 510 Score = 60.8 bits (146), Expect = 3e-09 Identities = 36/82 (43%), Positives = 48/82 (58%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P+RF+ A A + P A + FS GPR CIGQ FAM E K V A L +F F+L PS + Sbjct: 424 FDPLRFSPENA-AGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDPSKM 482 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 L L+ K G+ + +K L Sbjct: 483 PIKVPQLILRSKNGIHLYLKPL 504
>CP3A7_HUMAN (P24462) Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (P450-HFLA)| Length = 503 Score = 41.2 bits (95), Expect(2) = 3e-09 Identities = 19/55 (34%), Positives = 33/55 (60%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 + MV++ETLRL+ A+ ++R D+ + + IPK ++I + +H D K W E Sbjct: 356 LDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWRE 410 Score = 39.3 bits (90), Expect(2) = 3e-09 Identities = 22/58 (37%), Positives = 29/58 (50%) Frame = -1 Query: 438 RTRDQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 R ++F P RF+ P+ F GPR CIG FA++ K + VLQ FSF Sbjct: 409 REPEKFLPERFSKKNKDNID-PYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSF 465
>CP3AL_CALJA (O18993) Cytochrome P450 3A21 (EC 1.14.14.1) (CYPIIIA21) (P450| CM3A-10) Length = 503 Score = 40.4 bits (93), Expect(2) = 4e-09 Identities = 19/55 (34%), Positives = 33/55 (60%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 + MV++ETLRL+ A+ ++R D+ + + IPK ++I + +H D K W E Sbjct: 356 LDMVVNETLRLFPLAMRLERVCKKDVEINGVFIPKGVVVMIPSYALHYDPKYWTE 410 Score = 39.7 bits (91), Expect(2) = 4e-09 Identities = 21/55 (38%), Positives = 28/55 (50%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F P RF+ P+ F GPR CIG FA++ K + VLQ FSF Sbjct: 412 EKFLPERFSKNNKDNID-PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 465
>THAS_PIG (P47787) Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS)| Length = 534 Score = 42.7 bits (99), Expect(2) = 7e-09 Identities = 21/59 (35%), Positives = 31/59 (52%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 + F+P RF A+ + P L F GPR+C+G +LE K + +L+KF F P Sbjct: 450 ETFDPERFT-AEAQRLQQPFTYLPFGAGPRSCLGVQLGLLEIKLTLLHILRKFRFEACP 507 Score = 36.6 bits (83), Expect(2) = 7e-09 Identities = 19/53 (35%), Positives = 25/53 (47%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 + MVL ETLR+Y PA R+ D V IP + + +H D K W Sbjct: 394 LDMVLSETLRMYPPAFRFTREAARDCEVLGQRIPAGTVLEVAVGALHHDPKHW 446
>CP3A8_MACFA (P33268) Cytochrome P450 3A8 (EC 1.14.14.1) (CYPIIIA8) (P450-MKNF2)| (P-450-MK2) Length = 503 Score = 40.8 bits (94), Expect(2) = 7e-09 Identities = 19/55 (34%), Positives = 33/55 (60%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 + MV++ETLR++ A+ ++R D+ + I IPK ++I + +H D K W E Sbjct: 356 LDMVVNETLRIFPIAMRLERVCKKDVEINGIFIPKGVVVMIPSYALHHDPKYWPE 410 Score = 38.5 bits (88), Expect(2) = 7e-09 Identities = 17/37 (45%), Positives = 21/37 (56%) Frame = -1 Query: 375 PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 P+ F GPR CIG FA++ K + VLQ FSF Sbjct: 429 PYIYTPFGSGPRNCIGMRFALMNMKLAIIRVLQNFSF 465
>C4D10_DROMT (O18596) Cytochrome P450 4d10 (EC 1.14.-.-) (CYPIVD10)| Length = 513 Score = 53.1 bits (126), Expect(2) = 9e-09 Identities = 33/82 (40%), Positives = 45/82 (54%), Gaps = 1/82 (1%) Frame = -1 Query: 423 FNPMRFANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 F P RF + V A K+ PHA + FS GPR CIGQ FAMLE K++ A VL+ + + Sbjct: 428 FKPERF-DVVTSAEKLNPHAYIPFSAGPRNCIGQKFAMLEIKAIAANVLRHYEIEFVGNA 486 Query: 246 VHAPADFLTLQPKFGLPVVMKL 181 +P L + P++ KL Sbjct: 487 EESPVLIAELILRTKDPLMFKL 508 Score = 25.8 bits (55), Expect(2) = 9e-09 Identities = 15/55 (27%), Positives = 24/55 (43%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 M + + ETLR+Y + RK + + IP I I F+ R + + E Sbjct: 370 MDLCIKETLRMYPSVPLLGRKVLQECEINGKIIPAGTNIGISPLFLGRSEDISSE 424
>THAS_HUMAN (P24557) Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS)| Length = 533 Score = 45.4 bits (106), Expect(2) = 1e-08 Identities = 24/59 (40%), Positives = 29/59 (49%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 + FNP RF AR P L F GPR+C+G +LE K + VL KF F P Sbjct: 449 ETFNPERFT-AEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 506 Score = 33.1 bits (74), Expect(2) = 1e-08 Identities = 17/53 (32%), Positives = 25/53 (47%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 + MV+ ETLR+Y PA R+ D V IP + + +H D + W Sbjct: 393 LDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHW 445
>THAS_MOUSE (P36423) Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS)| (TS) Length = 533 Score = 43.9 bits (102), Expect(2) = 1e-08 Identities = 23/59 (38%), Positives = 30/59 (50%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 + F+P RF AR + P L F GPR+C+G +L K + VL KF F SP Sbjct: 449 ETFDPERFT-AEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASP 506 Score = 34.7 bits (78), Expect(2) = 1e-08 Identities = 18/53 (33%), Positives = 25/53 (47%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 + MV+ ETLR+Y PA R+ D V IP + I +H D + W Sbjct: 393 LDMVISETLRMYPPAFRFTREAAQDCEVLGQRIPAGTVLEIAVGALHHDPEHW 445
>CP4AE_MOUSE (O35728) Cytochrome P450 4A14 precursor (EC 1.14.15.3) (CYPIVA14)| (Lauric acid omega-hydroxylase 3) (P450-LA-omega 3) Length = 507 Score = 50.4 bits (119), Expect(2) = 1e-08 Identities = 31/82 (37%), Positives = 43/82 (52%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RFA + + HA L FS G R CIG+ FAM E K +A L +F P+ + Sbjct: 428 FDPSRFAPDSSHHS---HAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLPDPTRI 484 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 P L L+ K G+ + +K L Sbjct: 485 PVPIARLVLKSKNGIHLCLKKL 506 Score = 28.1 bits (61), Expect(2) = 1e-08 Identities = 15/53 (28%), Positives = 26/53 (49%), Gaps = 1/53 (1%) Frame = -3 Query: 598 TMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVW 443 TM + E LRLY P + + R+ ++ + +IPK I +H + + W Sbjct: 370 TMCIKEALRLYPPVISVSRELSSPVTFPDGRSIPKGITATISIYGLHHNPRFW 422
>CP131_DROME (Q9VFJ0) Probable cytochrome P450 313a1 (EC 1.14.-.-)| (CYPCCCXIIIA1) Length = 492 Score = 40.0 bits (92), Expect(2) = 1e-08 Identities = 20/61 (32%), Positives = 31/61 (50%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 D FNP F K P+A + F+ G R CIG +AM+ +K + +L+ + + S Sbjct: 408 DNFNPDNFL-AENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKISTSTL 466 Query: 249 Y 247 Y Sbjct: 467 Y 467 Score = 38.5 bits (88), Expect(2) = 1e-08 Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 1/61 (1%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDM-VVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQP 416 V+ ETLRL R+T D+ + + IPK I I HR+ +VWG DA + P Sbjct: 353 VIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNP 412 Query: 415 D 413 D Sbjct: 413 D 413
>CP4C3_DROME (Q9VA27) Cytochrome P450 4c3 (EC 1.14.-.-) (CYPIVC3)| Length = 535 Score = 53.5 bits (127), Expect(2) = 2e-08 Identities = 35/80 (43%), Positives = 46/80 (57%), Gaps = 1/80 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF-ALSP 253 +QFNP F A + P A + FS GPR CIGQ FA+LE K+V++TVL+K+ A+ Sbjct: 451 EQFNPDNFLPENC-AGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDR 509 Query: 252 SYVHAPADFLTLQPKFGLPV 193 L L+PK GL V Sbjct: 510 REDLTLLGELILRPKDGLRV 529 Score = 24.6 bits (52), Expect(2) = 2e-08 Identities = 12/49 (24%), Positives = 24/49 (48%) Frame = -3 Query: 589 LHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 + ++LRL+ M R D+ +G +P +I +HR+ +V+ Sbjct: 399 IKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVF 447
>CP4FC_HUMAN (Q9HCS2) Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12)| Length = 524 Score = 44.3 bits (103), Expect(2) = 2e-08 Identities = 24/53 (45%), Positives = 32/53 (60%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++P RF ++ + P A + FS GPR CIGQ FAM E K V+A +L F F Sbjct: 440 YDPFRFDPENSKG-RSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRF 491 Score = 33.9 bits (76), Expect(2) = 2e-08 Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 1/54 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVW 443 +TM + E+LRL+ PA F+ R T D+V+ IPK +I +H + VW Sbjct: 381 LTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVW 434
>C13A5_CAEEL (Q27514) Putative cytochrome P450 CYP13A5 (EC 1.14.-.-)| Length = 520 Score = 40.8 bits (94), Expect(2) = 2e-08 Identities = 20/58 (34%), Positives = 32/58 (55%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 256 ++F P R+ +G L F +GPR CIG AM+E K ++ +L+K++F S Sbjct: 434 NEFRPERWESG-DELFYAKGGYLPFGMGPRICIGMRLAMMEKKMLLTHILKKYTFETS 490 Score = 37.4 bits (85), Expect(2) = 2e-08 Identities = 22/64 (34%), Positives = 32/64 (50%), Gaps = 1/64 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQ-RKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGS 425 M V+ E LR+Y A + RK + V + I K + + +H D KVWGEDA Sbjct: 376 MECVVKEALRMYPLASIVHNRKCMKETNVLGVQIEKGTNVQVDTWTLHYDPKVWGEDANE 435 Query: 424 VQPD 413 +P+ Sbjct: 436 FRPE 439
>C13A8_CAEEL (Q27516) Putative cytochrome P450 CYP13A8 (EC 1.14.-.-)| Length = 509 Score = 42.7 bits (99), Expect(2) = 2e-08 Identities = 19/55 (34%), Positives = 34/55 (61%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F P R+ + + A L+F GPR C+G FA+LE K +++ +L+K++F Sbjct: 428 EEFKPERWDSPLTPQ----QAYLSFGAGPRVCLGMRFALLEQKGLLSHILKKYTF 478 Score = 35.4 bits (80), Expect(2) = 2e-08 Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 1/64 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQ-RKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGS 425 M V+ E+LRL+ A F R+ + V+G + ++I +H DK VWG D Sbjct: 370 MDNVIKESLRLFPFASFANSRRCMRNTVIGEQIVEAGVDVMIDTWTLHHDKNVWGNDVEE 429 Query: 424 VQPD 413 +P+ Sbjct: 430 FKPE 433
>CP4F6_RAT (P51871) Cytochrome P450 4F6 (EC 1.14.14.1) (CYPIVF6)| Length = 537 Score = 42.7 bits (99), Expect(2) = 3e-08 Identities = 23/51 (45%), Positives = 29/51 (56%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 +NP RF + + P A + FS GPR CIGQ FAM E K +A L +F Sbjct: 440 YNPFRF-DPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRF 489 Score = 34.3 bits (77), Expect(2) = 3e-08 Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 1/54 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVW 443 +TM + E+LRL+ P L + R + D+V+ IPK + VI +H + VW Sbjct: 381 LTMCIKESLRLHPPVLLISRCCSQDIVLPDGRVIPKGNICVISIFGVHHNPSVW 434
>C13A3_CAEEL (Q27517) Putative cytochrome P450 CYP13A3 (EC 1.14.-.-)| Length = 520 Score = 43.5 bits (101), Expect(2) = 4e-08 Identities = 21/54 (38%), Positives = 33/54 (61%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 268 ++F P R+ +G +A A L F +GPR CIG A +E K ++A +L+K+S Sbjct: 434 NEFKPERWESGDEQAV-AKGAYLPFGLGPRICIGMRLAYMEEKMLLAQILKKYS 486 Score = 33.1 bits (74), Expect(2) = 4e-08 Identities = 21/64 (32%), Positives = 30/64 (46%), Gaps = 1/64 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQ-RKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGS 425 M V+ ETLRLY A + RK V + I + + +H D K WGE+A Sbjct: 376 MECVIKETLRLYPLASIVHNRKCMKSTTVLGMKIEEGTNVQADTWTLHYDPKFWGENANE 435 Query: 424 VQPD 413 +P+ Sbjct: 436 FKPE 439
>C356_FUNHE (Q8AXY5) Cytochrome P450 3A56 (EC 1.14.14.1) (CYPIIIA56)| Length = 496 Score = 38.5 bits (88), Expect(2) = 4e-08 Identities = 18/69 (26%), Positives = 40/69 (57%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 V++E+LRL+ A ++R + + I IPK+ ++I +HRD ++W E + +P+ Sbjct: 358 VINESLRLFPIAARLERVAKAAVEINGIVIPKDMVVMIPTWPLHRDPEIWPEPE-AFKPE 416 Query: 412 EVRERGRES 386 ++ +++ Sbjct: 417 RFSKKNKDN 425 Score = 38.1 bits (87), Expect(2) = 4e-08 Identities = 15/39 (38%), Positives = 25/39 (64%) Frame = -1 Query: 375 PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 P+ + F GPR CIG FA++ K + +LQ++SF++ Sbjct: 428 PYIYMPFGSGPRNCIGMRFALVLIKLAVVEILQQYSFSV 466
>THAS_RAT (P49430) Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS)| Length = 533 Score = 42.4 bits (98), Expect(2) = 6e-08 Identities = 22/59 (37%), Positives = 29/59 (49%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 + F+P RF AR + P L F GPR+C+G +L K + VL KF F P Sbjct: 449 ETFDPERFT-AEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACP 506 Score = 33.9 bits (76), Expect(2) = 6e-08 Identities = 18/53 (33%), Positives = 25/53 (47%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 + MV+ ETLR+Y PA R+ D V IP + I +H D + W Sbjct: 393 LDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHW 445
>C340_ORYLA (Q98T91) Cytochrome P450 3A40 (EC 1.14.14.1)| Length = 502 Score = 38.5 bits (88), Expect(2) = 6e-08 Identities = 18/57 (31%), Positives = 31/57 (54%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 ++F P RF+ + P+ + F GPR CIG FA++ K + +LQ + F++ Sbjct: 413 EKFKPERFSKE-NKDTFDPYTYMPFGAGPRNCIGMRFALVMMKLAVVEILQTYDFSV 468 Score = 37.7 bits (86), Expect(2) = 6e-08 Identities = 17/52 (32%), Positives = 31/52 (59%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 V++E+LRLY A ++R + V + IPK+ +++ +HRD ++W E Sbjct: 360 VVNESLRLYPIAARLERVAKATVEVNGLVIPKDMVVMVPTWPLHRDPELWPE 411
>C330_FUNHE (Q9PVE8) Cytochrome P450 3A30 (EC 1.14.14.1) (CYPIIIA30)| Length = 496 Score = 38.1 bits (87), Expect(2) = 6e-08 Identities = 15/39 (38%), Positives = 25/39 (64%) Frame = -1 Query: 375 PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 P+ + F GPR CIG FA++ K + +LQ++SF++ Sbjct: 428 PYIYMPFGSGPRNCIGMRFALVLIKLAVVEILQQYSFSV 466 Score = 38.1 bits (87), Expect(2) = 6e-08 Identities = 17/69 (24%), Positives = 40/69 (57%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 V++E+LRL+ A ++R + + + IPK+ ++I +HRD ++W E + +P+ Sbjct: 358 VINESLRLFPIAARLERVAKAAVEINGVVIPKDMVVMIPTWPLHRDPEIWPEPE-AFKPE 416 Query: 412 EVRERGRES 386 ++ +++ Sbjct: 417 RFSKKNKDN 425
>CP4B1_RABIT (P15128) Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (P450-isozyme| 5) Length = 506 Score = 56.2 bits (134), Expect = 7e-08 Identities = 32/82 (39%), Positives = 48/82 (58%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P+RF+ + + + P+A + FS GPR CIGQ FAM E K V A L +F F++ P + Sbjct: 420 FDPLRFSPENS-SGRHPYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSVDPLRL 478 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 L L+ K G+ + +K L Sbjct: 479 PIKLPQLVLRSKNGIHLYLKPL 500
>CP4B1_MOUSE (Q64462) Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1)| Length = 511 Score = 55.8 bits (133), Expect = 9e-08 Identities = 33/82 (40%), Positives = 45/82 (54%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P+RF+ + P A + FS GPR CIGQ FAM E K V A L +F F+ PS + Sbjct: 425 FDPLRFSPE-NMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKI 483 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 L L+ K G+ + +K L Sbjct: 484 PIKVPQLILRSKNGIHLYLKPL 505
>CP4B1_HUMAN (P13584) Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (P450-HP)| Length = 511 Score = 55.8 bits (133), Expect = 9e-08 Identities = 34/82 (41%), Positives = 46/82 (56%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+ +RF+ A + + P A + FS GPR CIGQ FAM E K V A L +F F+L PS + Sbjct: 425 FDSLRFSTENA-SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRL 483 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 L L+ K G + +K L Sbjct: 484 PIKMPQLVLRSKNGFHLHLKPL 505
>CP4D1_DROSI (O16805) Cytochrome P450 4d1 (EC 1.14.-.-) (CYPIVD1)| Length = 512 Score = 50.4 bits (119), Expect(2) = 9e-08 Identities = 27/54 (50%), Positives = 37/54 (68%), Gaps = 1/54 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 + F P RF + V A K+ P+A + FS GPR CIGQ FAMLE K+++A VL+ + Sbjct: 425 NSFKPERF-DVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHY 477 Score = 25.0 bits (53), Expect(2) = 9e-08 Identities = 14/53 (26%), Positives = 25/53 (47%) Frame = -3 Query: 595 MVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 + + ETLR+Y + RK D + IP I I ++ R ++++ E Sbjct: 371 LCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSE 423
>CP4D1_DROME (P33269) Cytochrome P450 4d1 (EC 1.14.-.-) (CYPIVD1)| Length = 512 Score = 50.4 bits (119), Expect(2) = 9e-08 Identities = 27/54 (50%), Positives = 37/54 (68%), Gaps = 1/54 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 + F P RF + V A K+ P+A + FS GPR CIGQ FAMLE K+++A VL+ + Sbjct: 425 NSFKPERF-DVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHY 477 Score = 25.0 bits (53), Expect(2) = 9e-08 Identities = 14/53 (26%), Positives = 25/53 (47%) Frame = -3 Query: 595 MVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 + + ETLR+Y + RK D + IP I I ++ R ++++ E Sbjct: 371 LCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSE 423
>C81E1_GLYEC (P93147) Cytochrome P450 81E1 (EC 1.14.13.89) (Isoflavone| 2'-hydroxylase) (P450 91A4) (CYP GE-3) Length = 499 Score = 46.2 bits (108), Expect(2) = 9e-08 Identities = 23/67 (34%), Positives = 42/67 (62%), Gaps = 1/67 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQP 416 V++ETLRLY PA L + T+ + +G +P++ ++I A +HRD ++W E A + +P Sbjct: 356 VINETLRLYTPAPLLLPHSTSDECNIGGYKVPQDTIVLINAWAIHRDPELWTE-ATTFKP 414 Query: 415 DEVRERG 395 + ++G Sbjct: 415 ERFEKKG 421 Score = 29.3 bits (64), Expect(2) = 9e-08 Identities = 13/36 (36%), Positives = 21/36 (58%) Frame = -1 Query: 366 LLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 L+AF +G RAC G+ A+ +A ++Q F + L Sbjct: 426 LIAFGMGRRACPGEGLAIRAISMTLALLIQCFDWKL 461
>CP52C_CANMA (P16496) Cytochrome P450 52A3 (EC 1.14.14.-) (CYPLIIA3)| (Alkane-inducible P450-ALK1-A) (P450-CM1) (CYP52A3-A) (Cytochrome P-450ALK) Length = 522 Score = 41.2 bits (95), Expect(2) = 1e-07 Identities = 24/64 (37%), Positives = 33/64 (51%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 +F P R+ R K+ A L F+ GPR C+GQ FA+ EA V+A + Q F S Sbjct: 442 EFRPERWFEPSTR--KLGWAYLPFNGGPRICLGQQFALTEASYVIARLAQMFEHLESKDE 499 Query: 246 VHAP 235 + P Sbjct: 500 TYPP 503 Score = 33.9 bits (76), Expect(2) = 1e-07 Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 9/69 (13%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVV---------GAITIPKEHAIVIGAPFMHRDKKVWG 440 VL+ETLR+Y R T D + I +PK ++V HR K+ +G Sbjct: 378 VLNETLRMYPSVPINFRTATRDTTLPRGGGKDGNSPIFVPKGSSVVYSVYKTHRLKQFYG 437 Query: 439 EDAGSVQPD 413 EDA +P+ Sbjct: 438 EDAYEFRPE 446
>CP4F4_RAT (P51869) Cytochrome P450 4F4 (EC 1.14.14.1) (CYPIVF4)| Length = 522 Score = 40.0 bits (92), Expect(2) = 1e-07 Identities = 19/35 (54%), Positives = 22/35 (62%) Frame = -1 Query: 375 PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 P A + FS GPR CIGQ FAM E K +A L +F Sbjct: 455 PLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRF 489 Score = 35.0 bits (79), Expect(2) = 1e-07 Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 5/73 (6%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGE---- 437 +TM + E+LRL+ P + R+ T D+V+ IPK +I H + VW + Sbjct: 381 LTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVY 440 Query: 436 DAGSVQPDEVRER 398 D P+ +++R Sbjct: 441 DPFRFDPENIKDR 453
>CP4A7_RABIT (P14581) Cytochrome P450 4A7 precursor (EC 1.14.15.3) (CYPIVA7)| (Lauric acid omega-hydroxylase) (P450-KA-2) Length = 511 Score = 55.1 bits (131), Expect = 2e-07 Identities = 34/82 (41%), Positives = 45/82 (54%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RFA G AR + HA L FS G R CIG+ FAM E K +A L +F P+ V Sbjct: 432 FDPSRFAPGSARHS---HAFLPFSGGSRNCIGKQFAMNELKVAVALTLVRFELLPDPTRV 488 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 P L L+ K G+ + ++ L Sbjct: 489 PIPITRLVLKSKNGIHLRLRKL 510
>CP4V3_MOUSE (Q9DBW0) Cytochrome P450 4V3 (EC 1.14.-.-)| Length = 525 Score = 48.1 bits (113), Expect(2) = 2e-07 Identities = 22/53 (41%), Positives = 37/53 (69%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 ++F P RF ++ + P+A + FS GPR CIGQ FA++E K+++A +L++F Sbjct: 437 EEFRPERFFPENSQG-RHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILRQF 488 Score = 26.6 bits (57), Expect(2) = 2e-07 Identities = 17/63 (26%), Positives = 28/63 (44%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 V+ ETLR++ R + D VG + K +I +HRD + + + P+ Sbjct: 384 VIKETLRVFPSVPLFARSLSEDCEVGGYKVTKGTEAIIIPYALHRDPRYFPD------PE 437 Query: 412 EVR 404 E R Sbjct: 438 EFR 440
>CP4A4_RABIT (P10611) Cytochrome P450 4A4 precursor (EC 1.14.14.1) (CYPIVA4)| (Prostaglandin omega-hydroxylase) (P450-P-2) Length = 510 Score = 48.5 bits (114), Expect(2) = 2e-07 Identities = 30/82 (36%), Positives = 43/82 (52%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RFA A + HA L FS G R CIG+ FAM E K +A L +F P+ + Sbjct: 431 FDPFRFAPDSAYHS---HAFLPFSGGARNCIGKQFAMRELKVAVALTLVRFELLPDPTRI 487 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 P + L+ K G+ + ++ L Sbjct: 488 PIPIARVVLKSKNGIHLRLRKL 509 Score = 26.2 bits (56), Expect(2) = 2e-07 Identities = 15/53 (28%), Positives = 26/53 (49%), Gaps = 1/53 (1%) Frame = -3 Query: 598 TMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVW 443 TM + E LRLY P + R+ + + ++PK + + +H + KVW Sbjct: 373 TMCIKEALRLYPPVPSVTRQLSKPVTFPDGRSLPKGVILFLSIYGLHYNPKVW 425
>CP3AP_MOUSE (O09158) Cytochrome P450 3A25 (EC 1.14.14.1) (CYPIIIA25)| Length = 503 Score = 39.3 bits (90), Expect(2) = 2e-07 Identities = 18/55 (32%), Positives = 34/55 (61%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 + MV++E+LRLY A+ ++R + D+ + + IPK ++I +HR+ + W E Sbjct: 356 LDMVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPE 410 Score = 35.4 bits (80), Expect(2) = 2e-07 Identities = 15/36 (41%), Positives = 21/36 (58%) Frame = -1 Query: 375 PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 268 P+ + F GPR CIG FA++ K + VLQ F+ Sbjct: 429 PYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFT 464
>CP4F1_RAT (P33274) Cytochrome P450 4F1 (EC 1.14.14.1) (CYPIVF1) (P450-A3)| Length = 524 Score = 42.7 bits (99), Expect(2) = 2e-07 Identities = 23/51 (45%), Positives = 29/51 (56%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 +NP RF + + P A + FS GPR CIGQ FAM E K +A L +F Sbjct: 440 YNPFRFDPENIKDSS-PLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRF 489 Score = 31.6 bits (70), Expect(2) = 2e-07 Identities = 18/54 (33%), Positives = 29/54 (53%), Gaps = 1/54 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVW 443 +TM + E+LRL+ P + R T D+++ TIPK +I +H + VW Sbjct: 381 LTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVW 434
>C4G15_DROME (Q9VYY4) Cytochrome P450 4g15 (EC 1.14.-.-) (CYPIVG15)| Length = 574 Score = 42.0 bits (97), Expect(2) = 3e-07 Identities = 20/53 (37%), Positives = 34/53 (64%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 D F P R AN + +A + FS GPR+C+G+ +AML+ K +++T+L+ + Sbjct: 494 DNFLPERQAN------RHYYAFVPFSAGPRSCVGRKYAMLKLKILLSTILRNY 540 Score = 32.0 bits (71), Expect(2) = 3e-07 Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 2/51 (3%) Frame = -3 Query: 589 LHETLRLYGPALFMQRKTTTDMVV--GAITIPKEHAIVIGAPFMHRDKKVW 443 L ETLR+Y P + R+ D+ + G IP+ + + +HR+ KV+ Sbjct: 435 LMETLRMYPPVPLIARELQEDLKLNSGNYVIPRGATVTVATVLLHRNPKVY 485
>C4D21_DROME (Q9VLZ7) Probable cytochrome P450 4d21 (EC 1.14.-.-) (CYPIVD21)| Length = 511 Score = 39.3 bits (90), Expect(2) = 3e-07 Identities = 18/51 (35%), Positives = 31/51 (60%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 F P R+ + + P A + FS GP+ CIGQ FA L+ K++++ V++ + Sbjct: 427 FKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHY 477 Score = 34.7 bits (78), Expect(2) = 3e-07 Identities = 16/46 (34%), Positives = 28/46 (60%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRD 455 V+ ET+RL+ P + R D+ +G ITIP +I++ +++RD Sbjct: 372 VIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRD 417
>C13A4_CAEEL (Q27513) Putative cytochrome P450 CYP13A4 (EC 1.14.-.-)| Length = 520 Score = 39.3 bits (90), Expect(2) = 3e-07 Identities = 20/57 (35%), Positives = 30/57 (52%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 256 +F P R+ G L F +GPR CIG AM+E K ++ +L+K++F S Sbjct: 435 EFKPERWETG-DELFYAKGGYLPFGMGPRICIGMRLAMMEEKLLLTHILKKYTFDTS 490 Score = 34.3 bits (77), Expect(2) = 3e-07 Identities = 21/64 (32%), Positives = 31/64 (48%), Gaps = 1/64 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGS 425 M V+ E LR+Y A L RK V + I + + + +H D KVWG+DA Sbjct: 376 MECVVKEALRMYPLASLVHNRKCMKKTNVLGVEIDEGTNVQVDTWTLHYDPKVWGDDASE 435 Query: 424 VQPD 413 +P+ Sbjct: 436 FKPE 439
>C13A7_CAEEL (Q27519) Putative cytochrome P450 CYP13A7 (EC 1.14.-.-)| Length = 518 Score = 42.0 bits (97), Expect(2) = 3e-07 Identities = 21/66 (31%), Positives = 36/66 (54%), Gaps = 4/66 (6%) Frame = -1 Query: 429 DQFNPMRFANG----VARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 262 ++F P R+ +G A+ +P F +GPR CIG AM+E K ++ +L+ ++F Sbjct: 434 NEFKPERWESGDELFFAKGGYLP-----FGMGPRICIGMRLAMMEMKMLLTNILKNYTFE 488 Query: 261 LSPSYV 244 +P V Sbjct: 489 TTPETV 494 Score = 31.6 bits (70), Expect(2) = 3e-07 Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 1/61 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQP 416 V+ E LRLY A L RK V + I I + +H D KVWG+D +P Sbjct: 379 VVKEALRLYPLASLVHNRKCLKTTNVLGMEIEAGTNINVDTWSLHHDPKVWGDDVNEFKP 438 Query: 415 D 413 + Sbjct: 439 E 439
>CP4Z1_HUMAN (Q86W10) Cytochrome P450 4Z1 (EC 1.14.14.1) (CYPIVZ1)| Length = 505 Score = 51.6 bits (122), Expect(2) = 3e-07 Identities = 31/81 (38%), Positives = 45/81 (55%), Gaps = 1/81 (1%) Frame = -1 Query: 423 FNPMRFANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 FNP+RF+ + K+ P+A + FS G R CIGQ+FA++E K +A L +F A S Sbjct: 424 FNPLRFSR--ENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSR 481 Query: 246 VHAPADFLTLQPKFGLPVVMK 184 P + L+ K G+ V K Sbjct: 482 PPQPVRQVVLKSKNGIHVFAK 502 Score = 21.9 bits (45), Expect(2) = 3e-07 Identities = 9/19 (47%), Positives = 12/19 (63%) Frame = -3 Query: 598 TMVLHETLRLYGPALFMQR 542 TM + E LRLY P + + R Sbjct: 366 TMCIKECLRLYAPVVNISR 384
>CP343_HUMAN (Q9HB55) Cytochrome P450 3A43 (EC 1.14.14.1)| Length = 503 Score = 37.4 bits (85), Expect(2) = 3e-07 Identities = 18/55 (32%), Positives = 30/55 (54%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 + MV++ETLRL+ + R D+ + + IPK A+++ +H D K W E Sbjct: 356 LDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTE 410 Score = 36.2 bits (82), Expect(2) = 3e-07 Identities = 27/85 (31%), Positives = 42/85 (49%), Gaps = 2/85 (2%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF-ALSP 253 ++F P RF+ + + + + F GPR CIG FA+ K + LQ FSF Sbjct: 412 EKFCPERFSKKNKDSIDL-YRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKE 470 Query: 252 SYVHAPADFL-TLQPKFGLPVVMKL 181 + + D L LQP+ P+V+K+ Sbjct: 471 TQIPLKLDNLPILQPE--KPIVLKV 493
>CP46A_MOUSE (Q9WVK8) Cytochrome p450 46A1 (EC 1.14.13.98) (Cholesterol| 24-hydroxylase) (CH24H) Length = 500 Score = 53.9 bits (128), Expect = 4e-07 Identities = 31/71 (43%), Positives = 38/71 (53%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 FNP RF G A K FS+G R+CIGQ FA +E K VMA +LQ+ F L P Sbjct: 411 FNPDRFGPG---APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVPGQR 467 Query: 243 HAPADFLTLQP 211 + TL+P Sbjct: 468 FGLQEQATLKP 478
>CP46A_HUMAN (Q9Y6A2) Cytochrome p450 46A1 (EC 1.14.13.98) (Cholesterol| 24-hydroxylase) (CH24H) Length = 500 Score = 53.9 bits (128), Expect = 4e-07 Identities = 31/71 (43%), Positives = 38/71 (53%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 FNP RF G A K FS+G R+CIGQ FA +E K VMA +LQ+ F L P Sbjct: 411 FNPDRFGPG---APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQR 467 Query: 243 HAPADFLTLQP 211 + TL+P Sbjct: 468 FGLQEQATLKP 478
>CP4X1_RAT (Q8K4D6) Cytochrome P450 4X1 (EC 1.14.14.1) (CYPIVX1)| Length = 507 Score = 53.9 bits (128), Expect = 4e-07 Identities = 33/82 (40%), Positives = 45/82 (54%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P+RF + + P A L FS GPR CIGQ FAMLE K +A L +F A + Sbjct: 424 FDPLRFTKENSEQ-RHPCAFLPFSSGPRNCIGQQFAMLELKVAIALTLLRFRVAADLTRP 482 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 A + L+PK G+ + +K L Sbjct: 483 PAFSSHTVLRPKHGIYLHLKKL 504
>CP310_DROME (Q9VJ71) Probable cytochrome P450 310a1 (EC 1.14.-.-) (CYPCCCXA1)| Length = 492 Score = 42.7 bits (99), Expect(2) = 6e-07 Identities = 31/96 (32%), Positives = 45/96 (46%), Gaps = 11/96 (11%) Frame = -1 Query: 426 QFNPMRF---ANGVARAAKVP--HALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 262 ++ P+RF AN V + + + F IG C+GQNFA L K + +LQ F Sbjct: 393 KYKPLRFLQTANDVGQCEDKTKSNVFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLE 452 Query: 261 LSPSYV------HAPADFLTLQPKFGLPVVMKLLDV 172 L + V H PA F + K GL V +K ++ Sbjct: 453 LDANQVKTLKVSHRPAPF--IHTKDGLKVKLKRREI 486 Score = 30.0 bits (66), Expect(2) = 6e-07 Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 2/57 (3%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQR--KTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 M M L ETLR Y P ++R + + + TI + +++ MHRD+K + E Sbjct: 334 MDMCLKETLRKYPPLPIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSE 390
>CP4AC_MOUSE (Q91WL5) Cytochrome P450 4A12 (EC 1.14.14.1) (CYPIVA12)| Length = 508 Score = 53.1 bits (126), Expect = 6e-07 Identities = 32/82 (39%), Positives = 45/82 (54%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RFA G +R + H+ L FS G R CIG+ FAM E K +A L +F P+ V Sbjct: 429 FDPSRFAPGSSRHS---HSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRV 485 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 P + L+ K G+ + +K L Sbjct: 486 PIPIPRIVLKSKNGIHLHLKKL 507
>CP4V2_PONPY (Q5RCN6) Cytochrome P450 4V2 (EC 1.14.-.-)| Length = 525 Score = 47.4 bits (111), Expect(2) = 7e-07 Identities = 22/53 (41%), Positives = 36/53 (67%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 ++F P RF A+ + P+A + FS GPR CIGQ FA++E K++++ +L+ F Sbjct: 437 EEFQPERFFPENAQG-RHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHF 488 Score = 25.0 bits (53), Expect(2) = 7e-07 Identities = 15/48 (31%), Positives = 21/48 (43%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKK 449 V+ ETLRL+ R + D V + K VI +HRD + Sbjct: 384 VIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPR 431
>CP4V2_HUMAN (Q6ZWL3) Cytochrome P450 4V2 (EC 1.14.-.-)| Length = 525 Score = 47.4 bits (111), Expect(2) = 7e-07 Identities = 22/53 (41%), Positives = 36/53 (67%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 ++F P RF A+ + P+A + FS GPR CIGQ FA++E K++++ +L+ F Sbjct: 437 EEFQPERFFPENAQG-RHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHF 488 Score = 25.0 bits (53), Expect(2) = 7e-07 Identities = 15/48 (31%), Positives = 21/48 (43%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKK 449 V+ ETLRL+ R + D V + K VI +HRD + Sbjct: 384 VIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPR 431
>C13AA_CAEEL (Q09653) Putative cytochrome P450 CYP13A10 (EC 1.14.-.-)| Length = 519 Score = 38.9 bits (89), Expect(2) = 7e-07 Identities = 16/54 (29%), Positives = 30/54 (55%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 +F P R+ + ++F +GPR C+G A +E K ++A +L+K++F Sbjct: 435 EFKPERWLDPNCDQVFQKGGYISFGLGPRQCVGMRLAYMEEKMLLAHILRKYTF 488 Score = 33.5 bits (75), Expect(2) = 7e-07 Identities = 17/64 (26%), Positives = 31/64 (48%), Gaps = 1/64 (1%) Frame = -3 Query: 601 MTMVLHETLRLYG-PALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGS 425 M ++ ETLRLY + R+ +G + + + + +H D K+WG+DA Sbjct: 376 MDCIIKETLRLYPLGTMANSRRCMRATKLGNVEVEVGTMVQVDTWSLHTDTKIWGDDAKE 435 Query: 424 VQPD 413 +P+ Sbjct: 436 FKPE 439
>CP4AA_RAT (P08516) Cytochrome P450 4A10 (EC 1.14.15.3) (CYPIVA10) (Lauric| acid omega-hydroxylase) (P450-LA-omega 1) (P452) Length = 509 Score = 52.4 bits (124), Expect = 1e-06 Identities = 32/82 (39%), Positives = 44/82 (53%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RFA R + H+ L FS G R CIG+ FAM E K ++A L +F P+ V Sbjct: 430 FDPSRFAPDSPRHS---HSFLPFSGGARNCIGKQFAMSEMKVIVALTLLRFELLPDPTKV 486 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 P L L+ K G+ + +K L Sbjct: 487 PIPLPRLVLKSKNGIYLYLKKL 508 Score = 30.0 bits (66), Expect = 5.4 Identities = 20/70 (28%), Positives = 31/70 (44%), Gaps = 5/70 (7%) Frame = -3 Query: 598 TMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGE----D 434 TM + E LRLY P + R+ +T + ++PK + + +H + KVW D Sbjct: 372 TMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGIQVTLSIYGLHHNPKVWPNPEVFD 431 Query: 433 AGSVQPDEVR 404 PD R Sbjct: 432 PSRFAPDSPR 441
>CP52B_CANTR (P30607) Cytochrome P450 52A2 (EC 1.14.14.-) (CYPLIIA2)| (Alkane-inducible P450-ALK2) Length = 522 Score = 42.4 bits (98), Expect(2) = 1e-06 Identities = 24/65 (36%), Positives = 37/65 (56%), Gaps = 1/65 (1%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS-FALSPS 250 +F P R+ + K+ A L F+ GPR C+GQ FA+ EA V +LQ+FS + P+ Sbjct: 441 EFRPERWFEPETK--KLGWAFLPFNGGPRICLGQQFALTEASYVTVRLLQEFSHLTMDPN 498 Query: 249 YVHAP 235 ++P Sbjct: 499 TEYSP 503 Score = 29.3 bits (64), Expect(2) = 1e-06 Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 9/69 (13%) Frame = -3 Query: 592 VLHETLRLYG--PALFMQRKTTTDMVVGA-------ITIPKEHAIVIGAPFMHRDKKVWG 440 VL+E LRLY P F T + G + + K ++ HR+K+++G Sbjct: 377 VLNECLRLYPSVPQNFRVATRNTTLPRGGGKDGLSPVLVRKGQTVMYSVYAAHRNKQIYG 436 Query: 439 EDAGSVQPD 413 EDA +P+ Sbjct: 437 EDALEFRPE 445
>CP17A_MOUSE (P27786) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 507 Score = 39.7 bits (91), Expect(2) = 1e-06 Identities = 23/59 (38%), Positives = 31/59 (52%), Gaps = 1/59 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 256 D+F P RF + P + L F GPR+CIG+ A E MA +LQ+F F +S Sbjct: 409 DRFMPERFLDPTGSHLITPTPSYLPFGAGPRSCIGEALARQELFIFMALLLQRFDFDVS 467 Score = 32.0 bits (71), Expect(2) = 1e-06 Identities = 16/52 (30%), Positives = 25/52 (48%), Gaps = 1/52 (1%) Frame = -3 Query: 589 LHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 + E LR+ A L + K D +G IPK+ ++I +H DK W + Sbjct: 356 IREVLRIRPVAPLLIPHKANIDSSIGEFAIPKDTHVIINLWALHHDKNEWDQ 407
>CP4G1_DROME (Q9V3S0) Cytochrome P450 4g1 (EC 1.14.-.-) (CYPIVG1)| Length = 556 Score = 41.2 bits (95), Expect(2) = 2e-06 Identities = 18/53 (33%), Positives = 34/53 (64%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 D F P R AN + ++ + FS GPR+C+G+ +AML+ K +++T+++ + Sbjct: 472 DNFLPERMAN------RHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNY 518 Score = 30.0 bits (66), Expect(2) = 2e-06 Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVV--GAITIPKEHAIVIGAPFMHRDKKVW 443 V+ ETLRLY P + R+ D+ + G T+PK +++ +HR ++ Sbjct: 412 VILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIY 463
>CP52F_CANTR (P30608) Cytochrome P450 52A6 (EC 1.14.14.-) (CYPLIIA6)| (Alkane-inducible P450-ALK3) Length = 524 Score = 42.7 bits (99), Expect(2) = 2e-06 Identities = 24/65 (36%), Positives = 34/65 (52%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 D F P R+ + K+ A + F+ GPR C+GQ FA+ EA V+ ++Q F SP Sbjct: 443 DDFRPERWFEPSTK--KLGWAYVPFNGGPRICLGQQFALTEASYVITRLVQMFETVSSPP 500 Query: 249 YVHAP 235 V P Sbjct: 501 DVEYP 505 Score = 28.5 bits (62), Expect(2) = 2e-06 Identities = 19/69 (27%), Positives = 30/69 (43%), Gaps = 9/69 (13%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVV---------GAITIPKEHAIVIGAPFMHRDKKVWG 440 +L+ETLR+Y R T D + I IPK + HR ++ +G Sbjct: 380 ILNETLRMYPSVPVNSRTATRDTTLPRGGGPNGTDPIFIPKGSTVAYIVYKTHRLEEYYG 439 Query: 439 EDAGSVQPD 413 +DA +P+ Sbjct: 440 KDADDFRPE 448
>C94A1_VICSA (O81117) Cytochrome P450 94A1 (EC 1.14.-.-) (P450-dependent fatty| acid omega-hydroxylase) Length = 514 Score = 38.5 bits (88), Expect(2) = 2e-06 Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 2/63 (3%) Frame = -1 Query: 357 FSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAPA--DFLTLQPKFGLPVVMK 184 F GPR C+G+ A ++ K ++A ++ KF P FL+ Q + G PV ++ Sbjct: 451 FQAGPRVCLGKEMAFMQMKRIVAGIVGKFKVVPEAHLAQEPGFISFLSSQMEGGFPVTIQ 510 Query: 183 LLD 175 D Sbjct: 511 KRD 513 Score = 32.3 bits (72), Expect(2) = 2e-06 Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 1/71 (1%) Frame = -3 Query: 589 LHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPF-MHRDKKVWGEDAGSVQPD 413 L E++RLY P ++ D V+ + K+ IV + M R K +WG+D +P+ Sbjct: 367 LSESMRLYPPVPMDSKEAVNDDVLPDGWVVKKGTIVTYHVYAMGRMKSLWGDDWAEFRPE 426 Query: 412 EVRERGRESGQ 380 E+ +G+ Sbjct: 427 RWLEKDEVNGK 437
>C4D20_DROME (Q9W011) Probable cytochrome P450 4d20 (EC 1.14.-.-) (CYPIVD20)| Length = 510 Score = 37.4 bits (85), Expect(2) = 2e-06 Identities = 20/49 (40%), Positives = 28/49 (57%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQ 277 F P RF + A + FS GP+ CIGQ FA+LE K +++ VL+ Sbjct: 427 FRPERFLEDQEQGHNT-FAYVPFSAGPKNCIGQKFAVLEMKVLISKVLR 474 Score = 33.5 bits (75), Expect(2) = 2e-06 Identities = 20/64 (31%), Positives = 32/64 (50%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 V+ ET+RLY P + R ++ +G TIP +I + + HRD + D S +P+ Sbjct: 372 VIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYF-PDPLSFRPE 430 Query: 412 EVRE 401 E Sbjct: 431 RFLE 434
>CP133_DROME (Q9VGB3) Probable cytochrome P450 313a3 (EC 1.14.-.-)| (CYPCCCXIIIA3) Length = 492 Score = 38.1 bits (87), Expect(2) = 2e-06 Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 1/61 (1%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGA-ITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQP 416 V++ETLRL F R+T D + + + IPK I I HR++ WG D S P Sbjct: 353 VVNETLRLIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNP 412 Query: 415 D 413 D Sbjct: 413 D 413 Score = 32.7 bits (73), Expect(2) = 2e-06 Identities = 18/59 (30%), Positives = 30/59 (50%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 FNP F R + P+A + FS G R CIG + ++ +K ++ +L+ + S Y Sbjct: 410 FNPDHFLPDNVRD-RHPYAYIPFSKGRRNCIGWKYGLMSSKLALSKILRNCKVSTSFRY 467
>CP4AA_MOUSE (O88833) Cytochrome P450 4A10 (EC 1.14.15.3) (CYPIVA10) (Lauric| acid omega-hydroxylase) (P450-LA-omega 1) (P452) Length = 509 Score = 51.2 bits (121), Expect = 2e-06 Identities = 32/82 (39%), Positives = 44/82 (53%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RFA R + H+ L FS G R CIG+ FAM E K ++A L +F P+ V Sbjct: 430 FDPSRFAPDSPRHS---HSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRV 486 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 P L L+ K G+ + +K L Sbjct: 487 PMPLARLVLKSKNGIYLHLKKL 508 Score = 30.0 bits (66), Expect = 5.4 Identities = 20/70 (28%), Positives = 31/70 (44%), Gaps = 5/70 (7%) Frame = -3 Query: 598 TMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGE----D 434 TM + E LRLY P + R+ +T + ++PK + + +H + KVW D Sbjct: 372 TMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFD 431 Query: 433 AGSVQPDEVR 404 PD R Sbjct: 432 PSRFAPDSPR 441
>C13B1_CAEEL (O17624) Putative cytochrome P450 cyp-13B1 (EC 1.14.-.-)| Length = 527 Score = 37.4 bits (85), Expect(2) = 3e-06 Identities = 22/61 (36%), Positives = 31/61 (50%), Gaps = 1/61 (1%) Frame = -3 Query: 592 VLHETLRLYGPALFM-QRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQP 416 V+ E+LRLY A F R+ +G I I K I +HR K++WGE+A P Sbjct: 373 VVRESLRLYPVAWFACSRECVKPTTLGDIYIDKGVKIEADVMSLHRSKEIWGENADDFVP 432 Query: 415 D 413 + Sbjct: 433 E 433 Score = 33.1 bits (74), Expect(2) = 3e-06 Identities = 16/53 (30%), Positives = 28/53 (52%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 D F P R+ +R + + F GPR C+G + EAK+ +A +L+++ Sbjct: 428 DDFVPERWLEPSSRHTM---SWIPFGAGPRQCVGMRLGLSEAKTALAHLLRRY 477
>CP4D2_DROME (Q27589) Cytochrome P450 4d2 (EC 1.14.-.-) (CYPIVD2)| Length = 501 Score = 50.8 bits (120), Expect = 3e-06 Identities = 29/65 (44%), Positives = 38/65 (58%), Gaps = 1/65 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS-FALSP 253 D+F P RF V + P+A + FS GPR CIGQ FAMLE KS ++ +L+ F L P Sbjct: 420 DEFRPERFDADVPQIH--PYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGP 477 Query: 252 SYVHA 238 H+ Sbjct: 478 EPRHS 482
>CP132_MYCTU (P77900) Putative cytochrome P450 132 (EC 1.14.-.-)| Length = 461 Score = 50.8 bits (120), Expect = 3e-06 Identities = 31/80 (38%), Positives = 44/80 (55%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 D+F+P RF + A L F G R CIGQ+FA++E + A + Q F+F L+P Sbjct: 380 DRFDPGRFLRCPTDRPRC--AYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPG 437 Query: 249 YVHAPADFLTLQPKFGLPVV 190 Y LTL+PK G+ V+ Sbjct: 438 YHVELEATLTLRPKHGVHVI 457
>CP132_MYCBO (P59954) Putative cytochrome P450 132 (EC 1.14.-.-)| Length = 461 Score = 50.8 bits (120), Expect = 3e-06 Identities = 31/80 (38%), Positives = 44/80 (55%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 D+F+P RF + A L F G R CIGQ+FA++E + A + Q F+F L+P Sbjct: 380 DRFDPGRFLRCPTDRPRC--AYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPG 437 Query: 249 YVHAPADFLTLQPKFGLPVV 190 Y LTL+PK G+ V+ Sbjct: 438 YHVELEATLTLRPKHGVHVI 457
>CP4E1_DROME (Q9V4T5) Probable cytochrome P450 4e1 (EC 1.14.-.-) (CYPIVE1)| Length = 531 Score = 43.5 bits (101), Expect(2) = 4e-06 Identities = 22/52 (42%), Positives = 31/52 (59%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 +F P RF R P + FS GPR CIGQ FA+LE K+V++ +++ F Sbjct: 418 KFQPERFD----REKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNF 465 Score = 26.6 bits (57), Expect(2) = 4e-06 Identities = 16/63 (25%), Positives = 30/63 (47%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + + + E RLY F+ R T D V+ +PK + +G + + +V+ +D Sbjct: 361 LDLFIKEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVF-KDPHKF 419 Query: 421 QPD 413 QP+ Sbjct: 420 QPE 422
>C13A1_CAEEL (Q27520) Putative cytochrome P450 CYP13A1 (EC 1.14.-.-)| Length = 519 Score = 38.1 bits (87), Expect(2) = 4e-06 Identities = 17/55 (30%), Positives = 28/55 (50%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 + F P R+ + + F +GPR CIG A +E K ++ +L+KF+F Sbjct: 434 EDFKPERWQTPNSDQIYQKSGYIPFGLGPRQCIGMRLAYMEEKILLVHILRKFTF 488 Score = 32.0 bits (71), Expect(2) = 4e-06 Identities = 18/64 (28%), Positives = 29/64 (45%), Gaps = 1/64 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQ-RKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGS 425 M V E LRLY F R+ + +G + + I + +H D +WG+DA Sbjct: 376 MECVFKEALRLYPLGAFANSRRCMRNTKLGNMKVEVGTMIQVDTWTLHTDPNIWGDDAED 435 Query: 424 VQPD 413 +P+ Sbjct: 436 FKPE 439
>CP4A5_RABIT (P14579) Cytochrome P450 4A5 precursor (EC 1.14.15.3) (CYPIVA5)| (Lauric acid omega-hydroxylase) Length = 511 Score = 50.4 bits (119), Expect = 4e-06 Identities = 31/82 (37%), Positives = 43/82 (52%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RF G AR + HA L FS G R CIG+ FAM E K +A L +F P+ + Sbjct: 432 FDPGRFTPGSARHS---HAFLPFSGGARNCIGKQFAMNELKVAVALTLVRFELLPDPTRI 488 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 P L L+ G+ + ++ L Sbjct: 489 PKPTARLVLKSNNGIHLRLRKL 510
>CP52A_CANTR (P10615) Cytochrome P450 52A1 (EC 1.14.14.-) (CYPLIIA1)| (Alkane-inducible P450-ALK1) Length = 543 Score = 38.9 bits (89), Expect(2) = 5e-06 Identities = 30/85 (35%), Positives = 43/85 (50%), Gaps = 3/85 (3%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF-SFALSPSY 247 F P R+ R K+ A + F+ GPR C+GQ FA+ EA V +LQ+F + P+ Sbjct: 460 FRPERWFEPETR--KLGWAYVPFNGGPRICLGQQFALTEASYVTVRLLQEFGNLKQDPNT 517 Query: 246 VHAP--ADFLTLQPKFGLPVVMKLL 178 + P + LTL G V M L+ Sbjct: 518 EYPPKLQNTLTLSLFEGAEVQMYLI 542 Score = 30.8 bits (68), Expect(2) = 5e-06 Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 9/69 (13%) Frame = -3 Query: 592 VLHETLRLYG--PALFMQRKTTTDMVVGA-------ITIPKEHAIVIGAPFMHRDKKVWG 440 V++ETLR+Y P F T + G I I K ++ HRDK ++G Sbjct: 395 VINETLRIYPSVPHNFRVATRNTTLPRGGGEGGLSPIAIKKGQVVMYTILATHRDKDIYG 454 Query: 439 EDAGSVQPD 413 EDA +P+ Sbjct: 455 EDAYVFRPE 463
>CP4C1_BLADI (P29981) Cytochrome P450 4C1 (EC 1.14.14.1) (CYPIVC1)| Length = 511 Score = 47.4 bits (111), Expect(2) = 5e-06 Identities = 24/53 (45%), Positives = 34/53 (64%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 + FNP F A + P+A + FS GPR CIGQ FA LE K+V++++L+ F Sbjct: 422 EAFNPDNFLPERV-AKRHPYAYVPFSAGPRNCIGQKFATLEEKTVLSSILRNF 473 Score = 22.3 bits (46), Expect(2) = 5e-06 Identities = 12/47 (25%), Positives = 23/47 (48%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDK 452 V+ E+LRL+ F+ R D +G +P + + +HR++ Sbjct: 369 VIKESLRLFPSVPFIGRVLKEDTKIGDYLVPAGCMMNLQIYHVHRNQ 415
>C4AC3_DROME (Q9VMS7) Probable cytochrome P450 4ac3 (EC 1.14.-.-) (CYPIVAC3)| Length = 509 Score = 45.1 bits (105), Expect(2) = 5e-06 Identities = 26/55 (47%), Positives = 33/55 (60%), Gaps = 2/55 (3%) Frame = -1 Query: 429 DQFNPMRFA--NGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 +QF P RF N V R P A + FS GPR CIGQ F +LE K ++A V++ F Sbjct: 424 NQFLPERFLPENSVNRH---PFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNF 475 Score = 24.6 bits (52), Expect(2) = 5e-06 Identities = 14/48 (29%), Positives = 24/48 (50%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKK 449 V+ E+LRL+ A + R + V+ + +PK I I + RD + Sbjct: 371 VIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRDAR 418
>CP2R1_HUMAN (Q6VVX0) Cytochrome P450 2R1 (EC 1.14.14.-) (Vitamin D| 25-hydroxylase) Length = 501 Score = 39.7 bits (91), Expect(2) = 5e-06 Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 1/81 (1%) Frame = -1 Query: 438 RTRDQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 R + F+P RF + AK AL+ FS+G R C+G++ A +E +LQ+F Sbjct: 415 RDPEVFHPERFLDSSGYFAK-KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF---- 469 Query: 258 SPSYVHAPADFL-TLQPKFGL 199 ++H P + + L+P+ G+ Sbjct: 470 ---HLHFPHELVPDLKPRLGM 487 Score = 30.0 bits (66), Expect(2) = 5e-06 Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 1/51 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 VLHE LR L + T+ D VV +IPK ++ +H D+K W Sbjct: 364 VLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414
>CP132_DROME (Q9VGB4) Probable cytochrome P450 313a2 (EC 1.14.-.-)| (CYPCCCXIIIA2) Length = 493 Score = 35.0 bits (79), Expect(2) = 5e-06 Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 1/61 (1%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDM-VVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQP 416 VL+ETLRL F R+T D+ + + IPK I I R+ WG +A P Sbjct: 353 VLNETLRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNP 412 Query: 415 D 413 + Sbjct: 413 E 413 Score = 34.7 bits (78), Expect(2) = 5e-06 Identities = 18/60 (30%), Positives = 29/60 (48%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 QFNP F + P+A + FS G R CIG + ++ +K + +L+ + S Y Sbjct: 409 QFNPENFLPEKIHD-RHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKLKTSFPY 467
>CP4A6_RABIT (P14580) Cytochrome P450 4A6 precursor (EC 1.14.15.3) (CYPIVA6)| (Lauric acid omega-hydroxylase) (P450-KA-1) Length = 510 Score = 50.1 bits (118), Expect = 5e-06 Identities = 32/82 (39%), Positives = 42/82 (51%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P FA G AR + HA L FS GPR CIG+ FAM E K +A L +F P V Sbjct: 431 FDPFPFAPGSARHS---HAFLPFSGGPRNCIGKQFAMNELKVAVALTLVRFELLPDPKRV 487 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 L L+ G+ + ++ L Sbjct: 488 PDQKPRLVLKSSNGIHLRLRKL 509
>CP4AC_RAT (P24464) Cytochrome P450 4A12 (EC 1.14.14.1) (CYPIVA12) (CYPIVA8)| (P450-KP1) (P450-PP1) Length = 508 Score = 50.1 bits (118), Expect = 5e-06 Identities = 31/82 (37%), Positives = 44/82 (53%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RFA +R + H+ L FS G R CIG+ FAM E K +A L +F P+ + Sbjct: 429 FDPYRFAPESSRHS---HSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRI 485 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 P L L+ K G+ + +K L Sbjct: 486 PIPIPRLVLKSKNGIYLRLKKL 507
>CP4X1_HUMAN (Q8N118) Cytochrome P450 4X1 (EC 1.14.14.1) (CYPIVX1)| Length = 509 Score = 50.1 bits (118), Expect = 5e-06 Identities = 30/82 (36%), Positives = 45/82 (54%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P+RF+ + + P+A L FS G R CIGQ FAM+E K +A +L F P+ Sbjct: 426 FDPLRFSQENSDQ-RHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRP 484 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 + L+PK G+ + +K L Sbjct: 485 LTFPNHFILKPKNGMYLHLKKL 506
>CP4A2_RAT (P20816) Cytochrome P450 4A2 precursor (EC 1.14.15.3) (CYPIVA2)| (Lauric acid omega-hydroxylase) (P450-LA-omega 2) (P450 K-5) (P-450 K-2) Length = 504 Score = 50.1 bits (118), Expect = 5e-06 Identities = 31/82 (37%), Positives = 43/82 (52%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RF+ R + HA L FS G R CIG+ FAM E K +A L +F P+ + Sbjct: 425 FDPSRFSPDSPRHS---HAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRI 481 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 P L L+ K G+ + +K L Sbjct: 482 PVPMPRLVLKSKNGIHLRLKKL 503
>CP9E2_BLAGE (Q964T2) Cytochrome P450 9e2 (EC 1.14.-.-) (CYPIXE2)| Length = 533 Score = 39.7 bits (91), Expect(2) = 6e-06 Identities = 20/54 (37%), Positives = 32/54 (59%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 268 ++F+P RF++ K P L F GPR CIG FA++E+K + +L +F+ Sbjct: 445 EKFDPERFSDENKDNIK-PFTYLPFGSGPRNCIGNRFALMESKIALVHLLCRFN 497 Score = 29.6 bits (65), Expect(2) = 6e-06 Identities = 18/56 (32%), Positives = 29/56 (51%), Gaps = 3/56 (5%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDM---VVGAITIPKEHAIVIGAPFMHRDKKVW 443 + MV+ E+LRLY PA+F RK + + + T+ A+ I +H D K + Sbjct: 386 LDMVVSESLRLYPPAIFTDRKCVKNYRLPMEPSYTLEPGDAVWIPIYAIHHDPKYY 441
>CP17A_RAT (P11715) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 507 Score = 37.4 bits (85), Expect(2) = 6e-06 Identities = 22/59 (37%), Positives = 29/59 (49%), Gaps = 1/59 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVP-HALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 256 DQF P RF + P + L F GPR+CIG+ A E A +LQ+F +S Sbjct: 409 DQFMPERFLDPTGSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVS 467 Score = 32.0 bits (71), Expect(2) = 6e-06 Identities = 17/61 (27%), Positives = 29/61 (47%), Gaps = 1/61 (1%) Frame = -3 Query: 589 LHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 + E LR+ A + + K D +G T+PK+ +V+ +H D+ W QPD Sbjct: 356 IREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWD------QPD 409 Query: 412 E 410 + Sbjct: 410 Q 410
>CP4AE_RAT (P20817) Cytochrome P450 4A14 precursor (EC 1.14.15.3) (CYPIVA14)| (Lauric acid omega-hydroxylase) (P450-LA-omega 3) Length = 507 Score = 49.7 bits (117), Expect = 7e-06 Identities = 31/82 (37%), Positives = 43/82 (52%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RF+ R + HA L FS G R CIG+ FAM E K +A L +F P+ + Sbjct: 428 FDPSRFSPDSPRHS---HAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRI 484 Query: 243 HAPADFLTLQPKFGLPVVMKLL 178 P L L+ K G+ + +K L Sbjct: 485 PVPMARLVLKSKNGIHLRLKKL 506
>CP52H_CANTR (P30610) Cytochrome P450 52A8 (EC 1.14.14.-) (CYPLIIA8)| (Alkane-inducible P450-ALK5) Length = 517 Score = 41.6 bits (96), Expect(2) = 1e-05 Identities = 25/65 (38%), Positives = 35/65 (53%), Gaps = 1/65 (1%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF-SFALSPS 250 +F P R+ R K+ A L F+ GPR C+GQ FA+ EA V+ + Q F + L P Sbjct: 436 EFRPERWNEPSTR--KLGWAYLPFNGGPRICLGQQFALTEAGYVLVRLAQSFDTLELKPP 493 Query: 249 YVHAP 235 V+ P Sbjct: 494 VVYPP 498 Score = 26.9 bits (58), Expect(2) = 1e-05 Identities = 20/72 (27%), Positives = 30/72 (41%), Gaps = 9/72 (12%) Frame = -3 Query: 589 LHETLRLYG--PALFMQRKTTTDMVVGA-------ITIPKEHAIVIGAPFMHRDKKVWGE 437 L+ETLR+Y P F T + G + + K A+ G H D +G+ Sbjct: 373 LNETLRVYPSVPRNFRIATKNTTLPRGGGSDGNSPVLVKKGEAVSYGINSTHLDPVYYGD 432 Query: 436 DAGSVQPDEVRE 401 DA +P+ E Sbjct: 433 DAAEFRPERWNE 444
>CP2R1_MOUSE (Q6VVW9) Cytochrome P450 2R1 (EC 1.14.14.-) (Vitamin D| 25-hydroxylase) Length = 501 Score = 38.5 bits (88), Expect(2) = 1e-05 Identities = 24/78 (30%), Positives = 40/78 (51%), Gaps = 1/78 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 D F P RF + K AL+ FS+G R C+G+ A +E ++LQ+F Sbjct: 418 DMFYPERFLDSNGYFTK-KEALIPFSLGRRHCLGEQLARMEMFLFFTSLLQQF------- 469 Query: 249 YVHAPADFL-TLQPKFGL 199 ++H P + + L+P+ G+ Sbjct: 470 HLHFPHELVPNLKPRLGM 487 Score = 30.0 bits (66), Expect(2) = 1e-05 Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 1/51 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 VLHE LR L + T+ D VV +IPK ++ +H D+K W Sbjct: 364 VLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414
>C4AC2_DROME (Q9VMS8) Probable cytochrome P450 4ac2 (EC 1.14.-.-) (CYPIVAC2)| Length = 497 Score = 41.2 bits (95), Expect(2) = 1e-05 Identities = 25/53 (47%), Positives = 31/53 (58%), Gaps = 2/53 (3%) Frame = -1 Query: 423 FNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 F P RF N V R P A + FS G R CIGQ FA+LE K ++A V++ F Sbjct: 413 FQPDRFFPENTVNRH---PFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNF 462 Score = 27.3 bits (59), Expect(2) = 1e-05 Identities = 16/51 (31%), Positives = 26/51 (50%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKK 449 M V+ E+LRL+ F+ R+ + VV + +PK I I + RD + Sbjct: 355 MECVIKESLRLFPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDAR 405
>CP52E_CANMA (P24458) Cytochrome P450 52A5 (EC 1.14.14.-) (CYPLIIA5)| (Alkane-inducible P450-ALK2-A) (CYP52A3-B) Length = 523 Score = 38.5 bits (88), Expect(2) = 1e-05 Identities = 22/64 (34%), Positives = 32/64 (50%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 +F P R+ R K+ A + F+ GPR C+GQ FA+ EA V+ + Q F S Sbjct: 443 EFRPERWFEPSTR--KLGWAYVPFNGGPRICLGQQFALTEASYVITRLAQMFEHLESKDE 500 Query: 246 VHAP 235 + P Sbjct: 501 TYPP 504 Score = 29.6 bits (65), Expect(2) = 1e-05 Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 9/69 (13%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVV---------GAITIPKEHAIVIGAPFMHRDKKVWG 440 VL+ETLR+Y R T D + I +PK ++V HR ++ +G Sbjct: 379 VLNETLRMYPSVPVNFRTATRDTTLPRGGGKDGTSPIFVPKGSSVVYTVYKTHRLEEYYG 438 Query: 439 EDAGSVQPD 413 +DA +P+ Sbjct: 439 KDAYEFRPE 447
>CP4E2_DROME (Q27606) Cytochrome P450 4e2 (EC 1.14.-.-) (CYPIVE2)| Length = 526 Score = 41.6 bits (96), Expect(2) = 2e-05 Identities = 17/35 (48%), Positives = 25/35 (71%) Frame = -1 Query: 375 PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 P + FS GPR CIGQ FA+LE K+V++ +++ F Sbjct: 431 PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNF 465 Score = 26.2 bits (56), Expect(2) = 2e-05 Identities = 15/63 (23%), Positives = 31/63 (49%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + + + E R+Y F+ R T D V+ +PK + +G + ++KV+ +D Sbjct: 361 LDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVF-KDPHKF 419 Query: 421 QPD 413 +P+ Sbjct: 420 RPE 422
>C4AE1_DROME (O46054) Cytochrome P450 4ae1 (EC 1.14.-.-) (CYPIVAE1)| Length = 496 Score = 42.7 bits (99), Expect(2) = 2e-05 Identities = 22/64 (34%), Positives = 39/64 (60%) Frame = -1 Query: 375 PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAPADFLTLQPKFGLP 196 P++ + FS GPR CIGQ FA+LE K+++ V++ + + V P+ + L+ K G+ Sbjct: 430 PYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVE-PSIKIVLRSKSGVN 488 Query: 195 VVMK 184 V ++ Sbjct: 489 VGLR 492 Score = 25.0 bits (53), Expect(2) = 2e-05 Identities = 21/72 (29%), Positives = 36/72 (50%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 ++ V+ E+LRLY P + R D+V+ IP +V+ + RD+ ++ D Sbjct: 357 LSCVVKESLRLYPPIPAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIF-TDPLVF 415 Query: 421 QPDEVRERGRES 386 QP+ R G E+ Sbjct: 416 QPE--RHLGEEA 425
>CP1A4_CHICK (P79760) Cytochrome P450 1A4 (EC 1.14.14.1) (CYPIA4) (P450 TCDDAHH)| Length = 530 Score = 39.3 bits (90), Expect(2) = 2e-05 Identities = 24/82 (29%), Positives = 37/82 (45%), Gaps = 2/82 (2%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHA--LLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 F P RF N A +L F +G R CIG++ E + T+LQ+ +L Sbjct: 438 FKPERFLNAAGTELSRTEADKVLIFGLGKRRCIGESIGRWEVFLFLTTILQQLEISL--- 494 Query: 249 YVHAPADFLTLQPKFGLPVVMK 184 AP + + P++GL + K Sbjct: 495 ---APGQRVDITPQYGLTMKYK 513 Score = 28.1 bits (61), Expect(2) = 2e-05 Identities = 14/42 (33%), Positives = 23/42 (54%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 TT D V+ IPK+ + I + D+K+W +D S +P+ Sbjct: 401 TTKDTVLNGYYIPKDTCVFINQWQANHDEKIW-KDPPSFKPE 441
>C13A2_CAEEL (Q27518) Putative cytochrome P450 CYP13A2 (EC 1.14.-.-)| Length = 515 Score = 36.2 bits (82), Expect(2) = 2e-05 Identities = 18/54 (33%), Positives = 30/54 (55%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 +F P R++ K A L F +GPR CIG A++E K ++ +L+ ++F Sbjct: 432 EFKPERWSTDEPLEHK--GAYLPFGLGPRQCIGMRLAIMEQKILLTHLLKNYTF 483 Score = 31.2 bits (69), Expect(2) = 2e-05 Identities = 19/64 (29%), Positives = 29/64 (45%), Gaps = 1/64 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGS 425 M V+ E LRLY A + RK V + I + + +H D ++WGED Sbjct: 373 MDCVIKEALRLYPLASISNSRKCMKTTTVNGVKIEAGVYVQMDTWSLHYDPELWGEDVKE 432 Query: 424 VQPD 413 +P+ Sbjct: 433 FKPE 436
>C28C1_DROME (Q9VYT8) Probable cytochrome P450 28c1 (EC 1.14.-.-) (CYPXXVIIIC1)| Length = 505 Score = 47.8 bits (112), Expect = 3e-05 Identities = 21/59 (35%), Positives = 31/59 (52%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 D F P RF +G + K L F GPR C+G + AK+ +A ++Q+F +SP Sbjct: 413 DVFRPERFLDGGLKNCKQQGIFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSP 471
>CP52J_CANMA (Q12588) Cytochrome P450 52A10 (EC 1.14.14.-) (CYPLIIA10)| (Alkane-inducible P450-ALK7) Length = 519 Score = 47.8 bits (112), Expect = 3e-05 Identities = 32/82 (39%), Positives = 45/82 (54%), Gaps = 3/82 (3%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF-SFALSP 253 ++F P R+ R K+ A L F+ GPR C+GQ FA+ EA V+A ++Q F + LSP Sbjct: 437 NEFRPERWFEPEVR--KLGWAFLPFNGGPRICLGQQFALTEASYVLARLIQSFETLELSP 494 Query: 252 SYVHAPA--DFLTLQPKFGLPV 193 + PA LT+ G PV Sbjct: 495 EAAYPPAKLSHLTMCLFDGTPV 516 Score = 32.3 bits (72), Expect = 1.1 Identities = 26/80 (32%), Positives = 38/80 (47%), Gaps = 14/80 (17%) Frame = -3 Query: 592 VLHETLRLYGP----ALFMQRKTTTDMVVGA-----ITIPKEHAIVIGAPFMHRDKKVWG 440 VL+ETLRLY A F + TT G I + K ++ + RD+K +G Sbjct: 374 VLNETLRLYPSVPRNARFAAKNTTLPHGGGPDGMSPILVRKGQTVMYSVYALQRDEKYYG 433 Query: 439 EDAGSVQPD-----EVRERG 395 +DA +P+ EVR+ G Sbjct: 434 KDANEFRPERWFEPEVRKLG 453
>C86A1_ARATH (P48422) Cytochrome P450 86A1 (EC 1.14.-.-) (CYPLXXXVI)| (P450-dependent fatty acid omega-hydroxylase) Length = 513 Score = 39.3 bits (90), Expect(2) = 3e-05 Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 3/84 (3%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVP---HALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 256 +F P R+ + P + +AF+ GPR C+G++ A + KSV + VL ++ Sbjct: 423 EFRPERWLTADGERFETPKDGYKFVAFNAGPRTCLGKDLAYNQMKSVASAVLLRYRVFPV 482 Query: 255 PSYVHAPADFLTLQPKFGLPVVMK 184 P + LTL K GL V ++ Sbjct: 483 PGHRVEQKMSLTLFMKNGLRVYLQ 506 Score = 27.7 bits (60), Expect(2) = 3e-05 Identities = 18/61 (29%), Positives = 29/61 (47%), Gaps = 2/61 (3%) Frame = -3 Query: 589 LHETLRLYGPALFMQRKTTTD--MVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQP 416 L ETLRLY P++ K D ++ +P+ + + R K +WGED +P Sbjct: 368 LAETLRLY-PSVPQDFKYVVDDDVLPDGTFVPRGSTVTYSIYSIGRMKTIWGEDCLEFRP 426 Query: 415 D 413 + Sbjct: 427 E 427
>CP3AD_MOUSE (Q64464) Cytochrome P450 3A13 (EC 1.14.14.1) (CYPIIIA13)| Length = 503 Score = 47.4 bits (111), Expect = 3e-05 Identities = 31/89 (34%), Positives = 45/89 (50%), Gaps = 1/89 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++ETLRLY A ++R TD+ + + IPK ++I +H+D K W E Sbjct: 356 LDMVVNETLRLYPIAGRLERVCKTDVEINGLFIPKGTVVMIPTFALHKDPKYWPE----- 410 Query: 421 QPDEVR-ERGRESGQGSARPARILDRAEG 338 P+E R ER + Q S P L G Sbjct: 411 -PEEFRPERFSKKNQDSINPYMYLPFGSG 438 Score = 40.4 bits (93), Expect = 0.004 Identities = 20/54 (37%), Positives = 29/54 (53%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 268 ++F P RF+ + P+ L F GPR CIG FA++ K + VLQ F+ Sbjct: 412 EEFRPERFSKKNQDSIN-PYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFT 464
>CP17A_ORYLA (P70085) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 517 Score = 40.8 bits (94), Expect(2) = 4e-05 Identities = 24/78 (30%), Positives = 41/78 (52%), Gaps = 1/78 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHA-LLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 D FNP RF + + +P + L F G R C+G+ A +E ++ +LQ+F+ ++ P Sbjct: 419 DLFNPGRFLSADGSSLTLPSSSYLPFGAGLRVCLGEALAKMELFLFLSWILQRFTLSVPP 478 Query: 252 SYVHAPADFLTLQPKFGL 199 S +L+ KFG+ Sbjct: 479 S-----QSLPSLEGKFGV 491 Score = 25.8 bits (55), Expect(2) = 4e-05 Identities = 15/50 (30%), Positives = 24/50 (48%), Gaps = 1/50 (2%) Frame = -3 Query: 589 LHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 + E LR+ A L + +D +G T+ K +VI +H D+K W Sbjct: 366 IREVLRIRPVAPLLIPHVALSDTSLGDFTVRKGTRVVINLWSLHHDEKEW 415
>CPXP_RHISN (P55544) Cytochrome P450 BJ-1 homolog (EC 1.14.14.-)| Length = 400 Score = 38.9 bits (89), Expect(2) = 4e-05 Identities = 27/75 (36%), Positives = 38/75 (50%), Gaps = 7/75 (9%) Frame = -1 Query: 423 FNPMRFAN----GVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF---SF 265 F+P F + + R AK PH LAFS GP CIG A LE K V ++ Q+F Sbjct: 319 FDPRHFEDPEIFDIGRDAK-PH--LAFSYGPHYCIGMALARLELKVVFGSIFQRFPALRL 375 Query: 264 ALSPSYVHAPADFLT 220 A++P + + +T Sbjct: 376 AVAPEELKLRKEIIT 390 Score = 27.7 bits (60), Expect(2) = 4e-05 Identities = 13/43 (30%), Positives = 22/43 (51%), Gaps = 3/43 (6%) Frame = -3 Query: 589 LHETLRLYGPALF---MQRKTTTDMVVGAITIPKEHAIVIGAP 470 + E LR+Y P + R TD+ + + IP E +++G P Sbjct: 273 VEEILRMYPPGAGWDGIMRYPRTDVTIAGVHIPAESKVLVGLP 315
>CP4D8_DROME (Q9VS79) Cytochrome P450 4d8 (EC 1.14.-.-) (CYPIVD8)| Length = 463 Score = 47.0 bits (110), Expect = 4e-05 Identities = 24/53 (45%), Positives = 35/53 (66%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 D+F P R NG +R A P ++ FS GPR CIGQ FA LE K ++A +++++ Sbjct: 381 DEFIPERHENG-SRVA--PFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREY 430
>CP52L_DEBHA (Q9Y757) Cytochrome P450 52A12 (EC 1.14.14.-) (Alkane hydroxylase| 1) (Alkane-inducible p450alk 1) (DH-ALK2) Length = 519 Score = 38.9 bits (89), Expect(2) = 5e-05 Identities = 22/51 (43%), Positives = 29/51 (56%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 F P R+ R K+ A L F+ GPR C+GQ FA+ EA V+A + Q F Sbjct: 440 FRPERWFEPETR--KLGWAFLPFNGGPRICLGQQFALTEASYVIARLAQLF 488 Score = 27.3 bits (59), Expect(2) = 5e-05 Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 9/69 (13%) Frame = -3 Query: 592 VLHETLRLYG--PALFMQRKTTTDMVVGA-------ITIPKEHAIVIGAPFMHRDKKVWG 440 +L+E LRLY P F + T + G I I K + MHRD++ +G Sbjct: 375 LLNEVLRLYPSVPQNFRVAQKDTSLPRGGGPNRDQPIFIAKGQTVTYTVYAMHRDEQFYG 434 Query: 439 EDAGSVQPD 413 +D+ +P+ Sbjct: 435 KDSEVFRPE 443
>CP52W_CANAP (Q12573) Cytochrome P450 52E2 (EC 1.14.14.-) (CYPLIIE2)| Length = 519 Score = 35.4 bits (80), Expect(2) = 5e-05 Identities = 14/32 (43%), Positives = 21/32 (65%) Frame = -1 Query: 363 LAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 268 + F+ GPR C+GQ FA+ EA + + Q+FS Sbjct: 452 IPFNGGPRICLGQQFALTEASYTLVRICQEFS 483 Score = 30.8 bits (68), Expect(2) = 5e-05 Identities = 21/73 (28%), Positives = 30/73 (41%), Gaps = 9/73 (12%) Frame = -3 Query: 592 VLHETLRLYG--PALFMQRKTTTDMVVGA-------ITIPKEHAIVIGAPFMHRDKKVWG 440 V+ E LRL+ P F + T G I +PK + M R+ +WG Sbjct: 368 VIREVLRLHPNVPLNFREAIADTTFPTGGGPNGDQPIFVPKGQKVFYATYVMQRNAGIWG 427 Query: 439 EDAGSVQPDEVRE 401 D+ S +PD E Sbjct: 428 PDSTSFRPDRWNE 440
>CP1A2_FELCA (Q5KQT6) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2)| Length = 512 Score = 35.4 bits (80), Expect(2) = 5e-05 Identities = 25/90 (27%), Positives = 42/90 (46%), Gaps = 14/90 (15%) Frame = -1 Query: 426 QFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA--- 262 +F P RF A+G A + ++ F +G R CIG+ A E +A +LQ+ F+ Sbjct: 422 EFRPERFLTADGTAINKILSEKVMIFGLGKRRCIGEVLAKWEVFLFLAILLQQLEFSVPA 481 Query: 261 -----LSPSY----VHAPADFLTLQPKFGL 199 L+P Y H + + +P+F + Sbjct: 482 GVKVDLTPIYGLTMRHVRCEHVQARPRFSI 511 Score = 30.8 bits (68), Expect(2) = 5e-05 Identities = 12/34 (35%), Positives = 20/34 (58%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 TT D + IP++H + I ++ D+KVWG+ Sbjct: 386 TTRDTTLNGFYIPEKHLVFINQWQVNHDQKVWGD 419
>CP17A_SQUAC (Q92113) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 509 Score = 35.0 bits (79), Expect(2) = 5e-05 Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 1/78 (1%) Frame = -1 Query: 429 DQFNPMRFANGVAR-AAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 D F+P RF + + + L F G R C+G+ A +E + +LQ+F+ + P Sbjct: 413 DAFDPGRFLDEDGKYVCSSSESYLPFGAGTRVCLGEMLARMELFLFTSWILQRFTVQVPP 472 Query: 252 SYVHAPADFLTLQPKFGL 199 Y P D + KFG+ Sbjct: 473 GY--PPPD---KEGKFGI 485 Score = 31.2 bits (69), Expect(2) = 5e-05 Identities = 16/54 (29%), Positives = 26/54 (48%), Gaps = 1/54 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 + +HE LR+ + L + D +G TIPK ++I +H D+K W Sbjct: 356 LNATIHEILRIQPVSPLLIPHVALADSSIGDYTIPKGTRVIINLWAIHHDEKEW 409
>CP52V_CANAP (P43083) Cytochrome P450 52E1 (EC 1.14.14.-) (CYPLIIE1)| Length = 519 Score = 35.0 bits (79), Expect(2) = 6e-05 Identities = 14/32 (43%), Positives = 21/32 (65%) Frame = -1 Query: 363 LAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 268 + F+ GPR C+GQ FA+ EA + + Q+FS Sbjct: 452 IPFNGGPRICLGQQFALTEASYTIVRICQEFS 483 Score = 30.8 bits (68), Expect(2) = 6e-05 Identities = 21/73 (28%), Positives = 30/73 (41%), Gaps = 9/73 (12%) Frame = -3 Query: 592 VLHETLRLYG--PALFMQRKTTTDMVVGA-------ITIPKEHAIVIGAPFMHRDKKVWG 440 V+ E LRL+ P F Q T + G + +PK + M R +WG Sbjct: 368 VIREVLRLHPNVPLNFRQAIVDTKLPTGGGPNGDQPVFVPKGQNVFYSTYSMQRRTDIWG 427 Query: 439 EDAGSVQPDEVRE 401 DA + +PD E Sbjct: 428 PDATTFRPDRWNE 440
>CP52T_CANMA (Q12585) Cytochrome P450 52D1 (EC 1.14.14.-) (CYPLIID1)| (Alkane-inducible P450-ALK4) Length = 505 Score = 39.3 bits (90), Expect(2) = 6e-05 Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 1/84 (1%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS-FALSPSY 247 F P R+ + + L F+ GPR C+GQ FA+ EA V+ + Q ++ +L P+ Sbjct: 417 FRPERWCEEPLIKKNLAWSYLPFNGGPRICLGQQFALTEASYVLTRLAQCYTKISLQPNS 476 Query: 246 VHAPADFLTLQPKFGLPVVMKLLD 175 P PK + + M LLD Sbjct: 477 FEYP-------PKKQVHLTMSLLD 493 Score = 26.6 bits (57), Expect(2) = 6e-05 Identities = 22/69 (31%), Positives = 31/69 (44%), Gaps = 9/69 (13%) Frame = -3 Query: 592 VLHETLRLYGP----ALFMQRKTTTDMVVGA-----ITIPKEHAIVIGAPFMHRDKKVWG 440 +LHETLRLY A F ++ TT G I I K + H D+K + Sbjct: 352 ILHETLRLYPSVPRNARFSKKNTTLPHGGGVDGMSPILIKKGQPVAYFICATHVDEKFYT 411 Query: 439 EDAGSVQPD 413 +DA +P+ Sbjct: 412 KDALIFRPE 420
>C4AA1_DROME (Q9V7G5) Probable cytochrome P450 4aa1 (EC 1.14.-.-) (CYPIVAA1)| Length = 514 Score = 46.2 bits (108), Expect = 7e-05 Identities = 29/86 (33%), Positives = 47/86 (54%), Gaps = 1/86 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 ++F P RF+ + + P+A L FS GPR CIG FA++E K++++ +L+ + Sbjct: 424 EKFQPERFSPENSEN-RHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTG 482 Query: 249 YVHAPADF-LTLQPKFGLPVVMKLLD 175 A F +TL+ GL V +K D Sbjct: 483 KTTIAATFRITLRASGGLWVRLKERD 508
>CP17A_ONCMY (P30437) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 514 Score = 37.0 bits (84), Expect(2) = 8e-05 Identities = 22/78 (28%), Positives = 38/78 (48%), Gaps = 1/78 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 + F+P RF N +P + L F G R C+G+ A +E ++ +LQ+ + +SP Sbjct: 417 EMFDPGRFLNEEGTGLCIPSPSYLPFGAGVRVCLGEALAKMEIFLFLSWILQRLTMTVSP 476 Query: 252 SYVHAPADFLTLQPKFGL 199 +L+ KFG+ Sbjct: 477 G-----QPLPSLEGKFGV 489 Score = 28.5 bits (62), Expect(2) = 8e-05 Identities = 16/50 (32%), Positives = 24/50 (48%), Gaps = 1/50 (2%) Frame = -3 Query: 589 LHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 + E LR+ A L + TD +G T+ K I+I +H D+K W Sbjct: 364 IREVLRIRPVAPLLIPHVAQTDTSIGKFTVRKGARIIINLWSLHHDEKEW 413
>CP11A_DASAM (Q92045) Cytochrome P450 11A1, mitochondrial precursor (EC| 1.14.15.6) (CYPXIA1) (P450(SCC)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase) (Fragment) Length = 514 Score = 34.3 bits (77), Expect(2) = 8e-05 Identities = 19/59 (32%), Positives = 26/59 (44%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 +Q+NP R+ G L F GPR CIG+ A + +M +LQ F P Sbjct: 434 EQYNPERWLKG----EDTHFRHLGFGFGPRQCIGRRIAETQMVLLMIHMLQNFKIETDP 488 Score = 31.2 bits (69), Expect(2) = 8e-05 Identities = 18/50 (36%), Positives = 27/50 (54%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+ ETLRLY A+ +QR D V+ IP + +G M R+ K++ Sbjct: 381 VVKETLRLYPVAISIQRYLNEDTVLQNYHIPAGTLVQLGLYAMGRNPKIF 430
>CP312_DROME (Q9VVN6) Probable cytochrome P450 312a1 (EC 1.14.-.-) (CYPCCCXIIA1)| Length = 510 Score = 35.8 bits (81), Expect(2) = 8e-05 Identities = 19/53 (35%), Positives = 29/53 (54%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 F P R+A G + + F G R+C+GQ +AM+ K V+A +L+ F F Sbjct: 427 FKPDRWAIGAEPKIEAT-TFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLF 478 Score = 29.6 bits (65), Expect(2) = 8e-05 Identities = 15/46 (32%), Positives = 22/46 (47%) Frame = -3 Query: 589 LHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDK 452 + ETLR+Y RK T + + IPK ++I +M R K Sbjct: 373 IKETLRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCK 418
>CP2S1_HUMAN (Q96SQ9) Cytochrome P450 2S1 (EC 1.14.14.1) (CYPIIS1)| Length = 504 Score = 45.8 bits (107), Expect = 1e-04 Identities = 32/87 (36%), Positives = 43/87 (49%), Gaps = 4/87 (4%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 ++FNP RF + R K A L FS+G R C+G+ A E T+LQ FS SP Sbjct: 410 EEFNPDRFLDADGRFRK-HEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLE-SP- 466 Query: 249 YVHAPADFLTLQPK----FGLPVVMKL 181 P D L+L+P F +P +L Sbjct: 467 ---CPPDTLSLKPTVSGLFNIPPAFQL 490
>CP1A5_CHICK (P79761) Cytochrome P450 1A5 (EC 1.14.14.1) (CYPIA5) (P450 TCDDAA)| Length = 528 Score = 37.7 bits (86), Expect(2) = 1e-04 Identities = 19/57 (33%), Positives = 29/57 (50%), Gaps = 2/57 (3%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHA--LLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 FNP RF N A ++ F +G R CIG+N E ++T+LQ+ F++ Sbjct: 436 FNPERFLNAEGTEVNKVDAEKVMTFGLGKRRCIGENIGKWEVFLFLSTLLQQLEFSI 492 Score = 27.3 bits (59), Expect(2) = 1e-04 Identities = 13/42 (30%), Positives = 23/42 (54%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 TT D V+ IPK+ + I ++ D+K+W +D + P+ Sbjct: 399 TTRDTVLNGYYIPKDRCVFINQWQVNHDEKLW-KDPQAFNPE 439
>CP52K_CANMA (Q12589) Cytochrome P450 52A11 (EC 1.14.14.-) (CYPLIIA11)| (Alkane-inducible P450-ALK8) Length = 519 Score = 45.4 bits (106), Expect = 1e-04 Identities = 31/82 (37%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF-SFALSP 253 ++F P R+ R K+ A L F+ GPR C+GQ FA+ EA V+ ++Q F + LSP Sbjct: 437 NEFRPERWFEPEVR--KLGWAFLPFNGGPRICLGQQFALTEASYVLVRLIQSFETLELSP 494 Query: 252 SYVHAPADF--LTLQPKFGLPV 193 + PA LT+ G PV Sbjct: 495 DAPYPPAKLTHLTMCLFDGAPV 516 Score = 29.3 bits (64), Expect = 9.3 Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 15/81 (18%) Frame = -3 Query: 592 VLHETLRLYGPAL-----FMQRKTTTDMVVGA-----ITIPKEHAIVIGAPFMHRDKKVW 443 V++ETLRLY P++ F TT G I + K ++ + RD+K + Sbjct: 374 VINETLRLY-PSVPRNGRFAAANTTLPHGGGPDGMSPILVRKGQTVMYSVYALQRDEKYY 432 Query: 442 GEDAGSVQPD-----EVRERG 395 G+DA +P+ EVR+ G Sbjct: 433 GKDANEFRPERWFEPEVRKLG 453
>CP52I_CANMA (Q12586) Cytochrome P450 52A9 (EC 1.14.14.-) (CYPLIIA9)| (Alkane-inducible P450-ALK5-A) Length = 521 Score = 45.4 bits (106), Expect = 1e-04 Identities = 25/64 (39%), Positives = 38/64 (59%), Gaps = 1/64 (1%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF-SFALSPSY 247 FNP R++ + K+ A L F+ GPR C+GQ FA+ EA V+ ++Q F L+P+ Sbjct: 441 FNPDRWSKPETK--KLGWAFLPFNGGPRICLGQQFALTEASYVLVRMIQNFKELELTPNT 498 Query: 246 VHAP 235 V+ P Sbjct: 499 VYPP 502
>CP1A1_RABIT (P05176) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450 isozyme| 6) (P-450 PHPAH1) (P450 LM6) Length = 518 Score = 39.7 bits (91), Expect(2) = 1e-04 Identities = 21/60 (35%), Positives = 31/60 (51%), Gaps = 1/60 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAK-VPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 + F P RF K + +L F +G R CIG+ LE +AT+LQ+ F++SP Sbjct: 429 EAFRPERFLTPSGAVDKALTEKVLLFGLGKRKCIGETIGRLEVFLFLATLLQQVEFSVSP 488 Score = 25.0 bits (53), Expect(2) = 1e-04 Identities = 10/34 (29%), Positives = 17/34 (50%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 TT D +G IPK + + + D ++WG+ Sbjct: 394 TTRDTSLGGFYIPKGRCVFVNQWQNNHDPELWGD 427
>CP53_ASPNG (P17549) Benzoate 4-monooxygenase (EC 1.14.13.12)| (Benzoate-para-hydroxylase) (Cytochrome P450 53) (BpH) Length = 517 Score = 38.9 bits (89), Expect(2) = 1e-04 Identities = 26/82 (31%), Positives = 39/82 (47%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 +QF P R+ + + A + FS GPRAC+G+N A +E + TV + F F + Sbjct: 431 EQFVPERW-DPARLTPRQKAAFIPFSTGPRACVGRNVAEMELLVICGTVFRLFEFEMQQE 489 Query: 249 YVHAPADFLTLQPKFGLPVVMK 184 + +P GL V MK Sbjct: 490 GPMETREGFLRKP-LGLQVGMK 510 Score = 25.8 bits (55), Expect(2) = 1e-04 Identities = 15/64 (23%), Positives = 31/64 (48%), Gaps = 4/64 (6%) Frame = -3 Query: 592 VLHETLRLYGP-ALFMQRKTTTD---MVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGS 425 V+ ET+R++ A+ + R+ + + T + + + +HR K++WG DA Sbjct: 373 VIWETMRIHSTSAMGLPREIPAGNPPVTISGHTFYPGDVVSVPSYTIHRSKEIWGPDAEQ 432 Query: 424 VQPD 413 P+ Sbjct: 433 FVPE 436
>C71B8_ARATH (P58048) Cytochrome P450 71B8 (EC 1.14.-.-)| Length = 506 Score = 32.3 bits (72), Expect(2) = 1e-04 Identities = 17/57 (29%), Positives = 27/57 (47%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 ++FNP RFAN + LL F G R+C G + + + +L F ++L Sbjct: 412 EEFNPERFANTSINYKGQHYELLPFGAGRRSCPGMTLGITILELGLLNILYYFDWSL 468 Score = 32.3 bits (72), Expect(2) = 1e-04 Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 1/54 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFM-QRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 + +V+ ET RL+ P F+ R+ +D+ + IPK I I + RD K W Sbjct: 355 LKLVIKETFRLHPPGPFLLPRQVMSDIEIQGYHIPKNAHIKISTYAIGRDPKCW 408
>CP2D6_PANTR (Q2XNC8) Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6)| Length = 497 Score = 40.0 bits (92), Expect(2) = 1e-04 Identities = 21/56 (37%), Positives = 31/56 (55%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F+P F + K P A L FS G RAC+G+ A +E ++LQ FSF++ Sbjct: 414 RFHPEHFLDAQGHFVK-PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468 Score = 24.6 bits (52), Expect(2) = 1e-04 Identities = 17/54 (31%), Positives = 25/54 (46%), Gaps = 2/54 (3%) Frame = -3 Query: 598 TMVLHETLRLYGPA--LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 T V+HE R +G L + T+ D+ V IPK + + +DK VW Sbjct: 357 TAVIHEVQR-FGDIVPLGVTHMTSRDIEVQGFRIPKGTTLFTNLSSVLKDKAVW 409
>CP2D6_HUMAN (P10635) Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6) (P450-DB1)| (Debrisoquine 4-hydroxylase) Length = 497 Score = 40.0 bits (92), Expect(2) = 1e-04 Identities = 21/56 (37%), Positives = 31/56 (55%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F+P F + K P A L FS G RAC+G+ A +E ++LQ FSF++ Sbjct: 414 RFHPEHFLDAQGHFVK-PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468 Score = 24.6 bits (52), Expect(2) = 1e-04 Identities = 16/54 (29%), Positives = 26/54 (48%), Gaps = 2/54 (3%) Frame = -3 Query: 598 TMVLHETLRLYGPA--LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 T V+HE R +G L + T+ D+ V IPK ++ + +D+ VW Sbjct: 357 TAVIHEVQR-FGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW 409
>CP9H1_DROME (Q9V6H1) Probable cytochrome P450 9h1 (EC 1.14.-.-) (CYPIXH1)| Length = 518 Score = 45.1 bits (105), Expect = 2e-04 Identities = 22/51 (43%), Positives = 32/51 (62%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 FNP RFA+G A ++V + F +GPR CIG A++E KS++ +L F Sbjct: 436 FNPERFADGHALESRV---YMPFGVGPRNCIGNRMALMELKSIVYQLLLNF 483
>CP19A_ORENI (P70091) Cytochrome P450 19A1 (EC 1.14.14.1) (Aromatase) (CYPXIX)| (Estrogen synthetase) (P-450AROM) Length = 522 Score = 45.1 bits (105), Expect = 2e-04 Identities = 23/54 (42%), Positives = 32/54 (59%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 268 +QFN F N V R P F GPRACIG++ AM+ KS++ T+L ++S Sbjct: 420 NQFNLEHFENNVPR----PPTFQPFGSGPRACIGKHMAMVMMKSILVTLLSQYS 469
>CP6G2_DROME (Q9V675) Probable cytochrome P450 6g2 (EC 1.14.-.-) (CYPVIG2)| Length = 519 Score = 36.6 bits (83), Expect(2) = 2e-04 Identities = 22/73 (30%), Positives = 33/73 (45%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 +F P RF+ R P+ + F +GP CIG+ F L+AK + +L+ S Sbjct: 431 KFLPERFSPE-NRKLHTPYTYMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMITTSERT 489 Query: 246 VHAPADFLTLQPK 208 H + L PK Sbjct: 490 PHR----MQLDPK 498 Score = 27.7 bits (60), Expect(2) = 2e-04 Identities = 14/44 (31%), Positives = 21/44 (47%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAP 470 M M+L E LR+Y P F+ R+ T+ K+ + G P Sbjct: 368 MQMILLEVLRMYPPLPFLDRECTSGRDYSLAPFHKKFVVPKGMP 411
>CP1A2_CAVPO (Q64391) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2)| Length = 515 Score = 37.7 bits (86), Expect(2) = 2e-04 Identities = 24/76 (31%), Positives = 36/76 (47%), Gaps = 4/76 (5%) Frame = -1 Query: 426 QFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 +F P RF AN A + +L F +G R CIG+ E +A +LQ+ F++ P Sbjct: 426 EFRPERFLLANNTAVDKTLSDKILLFGLGKRRCIGETLGRWEVFLFLAILLQQLEFSVPP 485 Query: 252 SYV--HAPADFLTLQP 211 P LT++P Sbjct: 486 GVKVDLTPVYGLTMKP 501 Score = 26.6 bits (57), Expect(2) = 2e-04 Identities = 13/42 (30%), Positives = 21/42 (50%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 TT D ++ IPK+ + I ++ D K W ED +P+ Sbjct: 390 TTRDTILNGFYIPKDRCVFINQWQVNHDPKQW-EDPFEFRPE 430
>C11B1_PIG (Q29552) Cytochrome P450 11B1, mitochondrial precursor (EC| 1.14.15.4) (CYPXIB1) (P450C11) (Steroid 11-beta-hydroxylase) Length = 503 Score = 35.0 bits (79), Expect(2) = 2e-04 Identities = 16/53 (30%), Positives = 29/53 (54%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 ++++P R+ + + PH LAF G R C+G+ A +E ++ VL+ F Sbjct: 421 ERYHPQRWLDNQGSGTRFPH--LAFGFGMRQCLGRRLAQVEMLLLLHHVLKNF 471 Score = 29.3 bits (64), Expect(2) = 2e-04 Identities = 14/30 (46%), Positives = 19/30 (63%) Frame = -3 Query: 589 LHETLRLYGPALFMQRKTTTDMVVGAITIP 500 L ETLRLY +F+ R T+D+V+ IP Sbjct: 369 LKETLRLYPVGIFLDRCVTSDLVLQNYHIP 398
>CYPE_BACSU (O08336) Probable bifunctional P-450:NADPH-P450 reductase 2| [Includes: Cytochrome P450 102 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)] Length = 1054 Score = 44.7 bits (104), Expect = 2e-04 Identities = 25/67 (37%), Positives = 36/67 (53%), Gaps = 2/67 (2%) Frame = -3 Query: 595 MVLHETLRLY--GPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 MVL+ETLRLY PA + K T ++ G I K + + P +HRD+ WG DA Sbjct: 319 MVLNETLRLYPTAPAFSLYAKEDT-VLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDF 377 Query: 421 QPDEVRE 401 +P+ + Sbjct: 378 RPERFED 384 Score = 42.0 bits (97), Expect = 0.001 Identities = 26/74 (35%), Positives = 36/74 (48%), Gaps = 1/74 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 + F P RF + + +PH A F G RACIG FA+ EA V+ VL+ F Sbjct: 375 EDFRPERFED----PSSIPHHAYKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHT 430 Query: 252 SYVHAPADFLTLQP 211 Y + LT++P Sbjct: 431 GYELKIKEALTIKP 444
>C13A6_CAEEL (Q27515) Putative cytochrome P450 CYP13A6 (EC 1.14.-.-)| Length = 518 Score = 44.7 bits (104), Expect = 2e-04 Identities = 27/86 (31%), Positives = 44/86 (51%), Gaps = 3/86 (3%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 + F P R+ NG + + + F GPR CIG A +E K ++A +L+++SF + + Sbjct: 432 EDFKPERWENGACEHLEHNGSYIPFGSGPRQCIGMRLAQMEQKILLAQILKEYSFRTTKN 491 Query: 249 YVHAPADF---LTLQPKFGLPVVMKL 181 P LTL P+ V++KL Sbjct: 492 -TQIPVKLVGKLTLSPE---SVIVKL 513 Score = 33.1 bits (74), Expect = 0.64 Identities = 26/119 (21%), Positives = 44/119 (36%), Gaps = 1/119 (0%) Frame = -3 Query: 592 VLHETLRLYGPALFMQ-RKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQP 416 V+ ETLRLY RK + + + + I + +H + ++WGED +P Sbjct: 377 VMKETLRLYPLGTTANTRKCMRETTINGVNFDEGMNIQVDTWTLHHNPRIWGEDVEDFKP 436 Query: 415 DEVRERGRESGQGSARPARILDRAEGVHRPELRDAGSQVGHGDGPAEVLLRSLAELRAR 239 +R E L GS + G GP + + LA++ + Sbjct: 437 ---------------------ERWENGACEHLEHNGSYIPFGSGPRQCIGMRLAQMEQK 474
>CP3AT_PIG (P79401) Cytochrome P450 3A29 (EC 1.14.14.1) (CYPIIIA29)| Length = 503 Score = 44.7 bits (104), Expect = 2e-04 Identities = 31/87 (35%), Positives = 41/87 (47%), Gaps = 3/87 (3%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 ++F P RF+ P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 412 EEFRPERFSKKHKDTIN-PYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKE 470 Query: 249 YVHAPADFLT---LQPKFGLPVVMKLL 178 P T QP+ PVV+K+L Sbjct: 471 -TQIPLKLTTQGLTQPE--KPVVLKIL 494 Score = 42.7 bits (99), Expect = 8e-04 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 1/89 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++ETLRLY A ++R D+ + + +PK +V+ +HRD +W E Sbjct: 356 LDMVVNETLRLYPIAARLERACKKDVEIHGVFVPKGTVVVVPVFVLHRDPDLWPE----- 410 Query: 421 QPDEVR-ERGRESGQGSARPARILDRAEG 338 P+E R ER + + + P L G Sbjct: 411 -PEEFRPERFSKKHKDTINPYTYLPFGTG 438
>CP3AC_CANFA (P24463) Cytochrome P450 3A12 (EC 1.14.14.1) (CYPIIIA12)| (P450-PBD-1) Length = 503 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 1/89 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MVL+ETLRLY A ++R D+ + + IPK +++ +HRD+ +W E Sbjct: 356 LDMVLNETLRLYPIAGRLERVCKKDVEISGVFIPKGTVVMVPTFTLHRDQSLWPE----- 410 Query: 421 QPDEVR-ERGRESGQGSARPARILDRAEG 338 P+E R ER + S P L G Sbjct: 411 -PEEFRPERFSRKNKDSINPYTYLPFGTG 438 Score = 44.3 bits (103), Expect = 3e-04 Identities = 22/55 (40%), Positives = 30/55 (54%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F P RF+ + P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 412 EEFRPERFSRKNKDSIN-PYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSF 465
>CP4F8_HUMAN (P98187) Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8)| Length = 520 Score = 44.7 bits (104), Expect = 2e-04 Identities = 24/51 (47%), Positives = 31/51 (60%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 ++P RF A+ + P A + FS GPR CIGQ FAM E K V+A L +F Sbjct: 440 YDPFRFDPENAQK-RSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRF 489 Score = 31.2 bits (69), Expect = 2.4 Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 5/73 (6%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGE---- 437 +TM L E+LRL+ P R T D+V+ + IPK + I +H + VW + Sbjct: 381 LTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVY 440 Query: 436 DAGSVQPDEVRER 398 D P+ ++R Sbjct: 441 DPFRFDPENAQKR 453
>CP3A2_RAT (P05183) Cytochrome P450 3A2 (EC 1.14.14.1) (CYPIIIA2) (P450-PCN2)| (P450/6-beta-A) (Testosterone 6-beta-hydroxylase) Length = 504 Score = 44.7 bits (104), Expect = 2e-04 Identities = 22/55 (40%), Positives = 32/55 (58%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F+P RF+ + + P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 413 EEFHPERFSKE-NKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSF 466 Score = 37.4 bits (85), Expect = 0.034 Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MVL+ETLRLY ++R D+ + + IPK + I +H D + W Sbjct: 357 LDMVLNETLRLYPIGNRLERVCKKDIELDGLFIPKGSVVTIPTYALHHDPQHW------P 410 Query: 421 QPDEVR-ERGRESGQGSARP 365 +P+E ER + +GS P Sbjct: 411 KPEEFHPERFSKENKGSIDP 430
>CP52D_CANMA (P16141) Cytochrome P450 52A4 (EC 1.14.14.-) (CYPLIIA4)| (Alkane-inducible P450-ALK3-A) (P450-CM2) Length = 537 Score = 38.1 bits (87), Expect(2) = 2e-04 Identities = 21/51 (41%), Positives = 29/51 (56%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 F P R+ R K+ A + F+ GPR C+GQ FA+ EA V +LQ+F Sbjct: 457 FRPERWFEPETR--KLGWAYVPFNGGPRICLGQQFALTEASYVTVRLLQEF 505 Score = 25.8 bits (55), Expect(2) = 2e-04 Identities = 11/33 (33%), Positives = 17/33 (51%) Frame = -3 Query: 511 ITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 I I K ++ HRD ++GEDA +P+ Sbjct: 428 IAIKKGQNVMYTISATHRDPSIYGEDANVFRPE 460
>CP4E5_DROMT (O44221) Cytochrome P450 4e5, mitochondrial precursor (EC 1.14.-.-)| (CYPIVE5) Length = 522 Score = 40.4 bits (93), Expect(2) = 2e-04 Identities = 21/52 (40%), Positives = 31/52 (59%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 +F P RF + P + FS GPR CIGQ FA+LE K+V++ +++ F Sbjct: 417 RFYPERFE----KQKPGPFEYVPFSAGPRNCIGQKFALLELKTVISKLVRTF 464 Score = 23.5 bits (49), Expect(2) = 2e-04 Identities = 13/55 (23%), Positives = 25/55 (45%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 + + + E R+Y F+ R T D + +PK + +G + D +V+ E Sbjct: 360 LDLFIKEAQRVYPSVPFIGRYTDKDYNIHGTIMPKGTTLNLGIIVLGYDDRVFEE 414
>CP2DK_MESAU (Q9QYG5) Cytochrome P450 2D20 (EC 1.14.14.-) (CYPIID20)| Length = 500 Score = 41.6 bits (96), Expect(2) = 2e-04 Identities = 28/77 (36%), Positives = 40/77 (51%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P F + R K A + FS G RAC+G+ A +E +LQ+FSF++ P+ Sbjct: 418 FHPEHFLDAQGRFVK-QEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSV-PAGQ 475 Query: 243 HAPADFLTLQPKFGLPV 193 P+D Q F LPV Sbjct: 476 PRPSD----QGVFALPV 488 Score = 22.3 bits (46), Expect(2) = 2e-04 Identities = 14/51 (27%), Positives = 24/51 (47%), Gaps = 1/51 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+HE R A + + T+ D+ V IPK ++ + +D+ VW Sbjct: 362 VIHEVQRFGDIAPVNVPHMTSRDVEVQGFLIPKGTTLIPNLSSVLKDETVW 412
>CP3AG_MOUSE (Q64481) Cytochrome P450 3A16 (EC 1.14.14.1) (CYPIIIA16)| Length = 504 Score = 44.3 bits (103), Expect = 3e-04 Identities = 28/80 (35%), Positives = 42/80 (52%), Gaps = 1/80 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MVL+ETLRLY +QR D+ + I IPK ++I + +H D + W E Sbjct: 357 LDMVLNETLRLYPITNRLQRVCKKDVEINGIYIPKGSTVIIPSYVLHHDPQHWPE----- 411 Query: 421 QPDEVR-ERGRESGQGSARP 365 P+E + ER + +GS P Sbjct: 412 -PEEFQPERFSKENKGSIDP 430 Score = 43.9 bits (102), Expect = 4e-04 Identities = 22/55 (40%), Positives = 31/55 (56%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F P RF+ + + P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 413 EEFQPERFSKE-NKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSF 466
>CP3A1_RAT (P04800) Cytochrome P450 3A1 (EC 1.14.14.1) (CYPIIIA1) (P450-PCN1)| Length = 504 Score = 44.3 bits (103), Expect = 3e-04 Identities = 22/55 (40%), Positives = 31/55 (56%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F P RF+ + + P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 413 EEFRPERFSKE-NKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSF 466 Score = 43.9 bits (102), Expect = 4e-04 Identities = 27/80 (33%), Positives = 43/80 (53%), Gaps = 1/80 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MVL+ETLRLY ++R D+ + + +PK ++I + +HRD + W E Sbjct: 357 LDMVLNETLRLYPIGNRLERVCKKDVEINGVFMPKGSVVMIPSYALHRDPQHWPE----- 411 Query: 421 QPDEVR-ERGRESGQGSARP 365 P+E R ER + +GS P Sbjct: 412 -PEEFRPERFSKENKGSIDP 430
>CP3A9_RAT (P51538) Cytochrome P450 3A9 (EC 1.14.14.1) (CYPIIIA9) (P450-OLF3)| (Olfactive) (3AH15) Length = 503 Score = 44.3 bits (103), Expect = 3e-04 Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 1/89 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++ETLRLY A ++R TD+ + + IPK ++I +H+D W E Sbjct: 356 LDMVVNETLRLYPIAGRLERVCKTDVEINGVFIPKGTVVMIPTFALHKDPHYWPE----- 410 Query: 421 QPDEVR-ERGRESGQGSARPARILDRAEG 338 P+E R ER + Q + P L G Sbjct: 411 -PEEFRPERFSKKNQDNINPYMYLPFGNG 438 Score = 41.6 bits (96), Expect = 0.002 Identities = 22/55 (40%), Positives = 29/55 (52%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F P RF+ P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 412 EEFRPERFSKKNQDNIN-PYMYLPFGNGPRNCIGMRFALMNMKVALFRVLQNFSF 465
>CP9B1_DROME (Q9V4I0) Cytochrome P450 9b1 (EC 1.14.-.-) (CYPIXB1)| Length = 505 Score = 44.3 bits (103), Expect = 3e-04 Identities = 18/58 (31%), Positives = 35/58 (60%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 +F+P RF+ + +P+ L F +GPR+CIG +A+++AK ++ ++ + SP Sbjct: 420 RFDPERFSER-RKKDLIPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASP 476
>CP1A1_PLEPL (Q92100) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1)| Length = 521 Score = 38.1 bits (87), Expect(2) = 3e-04 Identities = 26/82 (31%), Positives = 40/82 (48%), Gaps = 2/82 (2%) Frame = -1 Query: 423 FNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 FNP RF A+G ++AF +G R CIG+ A E +A ++QK F Sbjct: 432 FNPDRFLSADGSEVNKLDGEKVMAFGMGKRRCIGEVIARNEVYLFLAIIIQKLHF----- 486 Query: 249 YVHAPADFLTLQPKFGLPVVMK 184 + P + L + P++GL + K Sbjct: 487 -LPIPGEKLDMTPEYGLTMKHK 507 Score = 25.4 bits (54), Expect(2) = 3e-04 Identities = 13/42 (30%), Positives = 21/42 (50%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 TT D + IPK+ + I ++ D ++W +D S PD Sbjct: 395 TTKDTSLNGYFIPKDTCVFINQWQINHDPELW-KDPSSFNPD 435
>CP1A1_PLAFE (Q9YH64) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1)| Length = 521 Score = 38.1 bits (87), Expect(2) = 3e-04 Identities = 26/82 (31%), Positives = 40/82 (48%), Gaps = 2/82 (2%) Frame = -1 Query: 423 FNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 FNP RF A+G ++AF +G R CIG+ A E +A ++QK F Sbjct: 432 FNPDRFLSADGSEVNKLDGEKVMAFGMGKRRCIGEVIARNEVYLFLAIIIQKLHF----- 486 Query: 249 YVHAPADFLTLQPKFGLPVVMK 184 + P + L + P++GL + K Sbjct: 487 -LPIPGEKLDMTPEYGLTMKHK 507 Score = 25.4 bits (54), Expect(2) = 3e-04 Identities = 13/42 (30%), Positives = 21/42 (50%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 TT D + IPK+ + I ++ D ++W +D S PD Sbjct: 395 TTKDTSLNGYFIPKDTCVFINQWQINHDPELW-KDPSSFNPD 435
>CCD1P_DROME (P82712) Probable cytochrome P450 12d1 proximal, mitochondrial| precursor (EC 1.14.-.-) (CYPXIID1) Length = 521 Score = 35.0 bits (79), Expect(2) = 3e-04 Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 3/56 (5%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKV---PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 D+F P R+ K+ P L F GPR CIG+ LE ++ +A +++ F Sbjct: 433 DEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNF 488 Score = 28.5 bits (62), Expect(2) = 3e-04 Identities = 12/46 (26%), Positives = 24/46 (52%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRD 455 V+ ETLR Y L R D+++ +PK +++G+ + ++ Sbjct: 380 VIKETLRYYPNGLGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKE 425
>CP2D1_RAT (P10633) Cytochrome P450 2D1 (EC 1.14.14.1) (CYPIID1) (P450-DB1)| (P450-CMF1A) (P450-UT-7) (Debrisoquine 4-hydroxylase) Length = 504 Score = 36.2 bits (82), Expect(2) = 3e-04 Identities = 19/56 (33%), Positives = 30/56 (53%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F+P F + K A + FS G RAC+G+ A +E +LQ+FSF++ Sbjct: 417 RFHPEHFLDAQGNFVK-HEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSV 471 Score = 27.3 bits (59), Expect(2) = 3e-04 Identities = 17/51 (33%), Positives = 26/51 (50%), Gaps = 1/51 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+HE R A L + R T+ D+ V IPK ++I + +D+ VW Sbjct: 362 VIHEVQRFGDIAPLNLPRFTSCDIEVQDFVIPKGTTLIINLSSVLKDETVW 412
>CP1A1_RAT (P00185) Cytochrome P450 1A1 (EC 1.14.14.1) (CYP1A1) (CYPIA1)| (P450-C) (P450MT2) [Contains: Cytochrome P450MT2A; Cytochrome P450MT2B] Length = 524 Score = 37.7 bits (86), Expect(2) = 4e-04 Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 1/78 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAK-VPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 ++F P RF K + ++ F +G R CIG+ LE +A +LQ+ F +S Sbjct: 429 NEFRPERFLTSSGTLDKHLSEKVILFGLGKRKCIGETIGRLEVFLFLAILLQQMEFNVS- 487 Query: 252 SYVHAPADFLTLQPKFGL 199 P + + + P +GL Sbjct: 488 -----PGEKVDMTPAYGL 500 Score = 25.4 bits (54), Expect(2) = 4e-04 Identities = 9/34 (26%), Positives = 18/34 (52%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 T D + IPK H + + ++ D+++WG+ Sbjct: 394 TIRDTSLNGFYIPKGHCVFVNQWQVNHDQELWGD 427
>CP2D4_RAT (P13108) Cytochrome P450 2D4 (EC 1.14.14.1) (CYPIID4) (P450-DB4)| (P450-CMF3) (Debrisoquine 4-hydroxylase) Length = 500 Score = 38.1 bits (87), Expect(2) = 4e-04 Identities = 22/67 (32%), Positives = 36/67 (53%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 +F+P F + K A + FS G RAC+G+ A +E +LQ+FSF++ P+ Sbjct: 417 RFHPEHFLDAQGNFVK-HEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSV-PTG 474 Query: 246 VHAPADF 226 P+D+ Sbjct: 475 QPRPSDY 481 Score = 25.0 bits (53), Expect(2) = 4e-04 Identities = 15/51 (29%), Positives = 24/51 (47%), Gaps = 1/51 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+HE R L + KT+ D+ V IPK ++ + +D+ VW Sbjct: 362 VIHEVQRFADILPLGVPHKTSRDIEVQGFLIPKGTTLITNLSSVLKDETVW 412
>CP2DI_RAT (Q64680) Cytochrome P450 2D18 (EC 1.14.14.1) (CYPIID18) (P450| 2D-29/2D-35) Length = 500 Score = 36.2 bits (82), Expect(2) = 4e-04 Identities = 19/56 (33%), Positives = 30/56 (53%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F+P F + K A + FS G RAC+G+ A +E +LQ+FSF++ Sbjct: 417 RFHPEHFLDAQGNFVK-HEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSV 471 Score = 26.9 bits (58), Expect(2) = 4e-04 Identities = 16/51 (31%), Positives = 25/51 (49%), Gaps = 1/51 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+HE R L + KT+ D+ V IPK ++I + +D+ VW Sbjct: 362 VIHEVQRFADILPLGVPHKTSRDIEVQGFLIPKGTTLIINLSSVLKDETVW 412
>C71BU_ARATH (Q9SCN2) Cytochrome P450 71B31 (EC 1.14.-.-)| Length = 498 Score = 33.9 bits (76), Expect(2) = 4e-04 Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 1/54 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 + +V+ E+ RL+ PA L + R+T +D+ + IPK + I + RD K W Sbjct: 353 LNLVIKESFRLHPPAPLLLPRETMSDIEIQGYHIPKNAHVKINTYAIGRDPKRW 406 Score = 29.3 bits (64), Expect(2) = 4e-04 Identities = 16/57 (28%), Positives = 25/57 (43%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 ++FNP RF N + LL F G R C G + + + +L F ++L Sbjct: 410 EEFNPERFLNTSINYKGQHYELLPFGAGRRNCPGMTLGITILELGLLNILYYFDWSL 466
>CP4E3_DROME (Q9VL92) Cytochrome P450 4e3 (EC 1.14.-.-) (CYPIVE3)| Length = 526 Score = 43.9 bits (102), Expect = 4e-04 Identities = 23/51 (45%), Positives = 29/51 (56%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 F P RF P L FS GPR CIGQ FA+LE K+V++ V++ F Sbjct: 418 FRPERFEE----EKPAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSF 464
>CP3AR_ONCMY (O42563) Cytochrome P450 3A27 (EC 1.14.14.1) (CYPIIIA27)| Length = 518 Score = 43.9 bits (102), Expect = 4e-04 Identities = 20/57 (35%), Positives = 32/57 (56%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 ++F P RF+ + P+ + F GPR CIG FA++ K M +LQ F+F++ Sbjct: 417 EEFKPERFSKENKESID-PYTYMPFGAGPRNCIGMRFALIMIKLAMVEILQSFTFSV 472 Score = 41.6 bits (96), Expect = 0.002 Identities = 21/69 (30%), Positives = 38/69 (55%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 VL+E+LRLY A ++R + + I IPK+ +++ +HRD ++W D +P+ Sbjct: 364 VLNESLRLYPIAPRLERVAKKTVEINGIVIPKDCIVLVPTWTLHRDPEIW-SDPEEFKPE 422 Query: 412 EVRERGRES 386 + +ES Sbjct: 423 RFSKENKES 431
>CP3AO_SHEEP (Q29496) Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24)| Length = 503 Score = 43.9 bits (102), Expect = 4e-04 Identities = 22/55 (40%), Positives = 30/55 (54%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F P RF+ + P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 412 EEFRPERFSKKNKDSIN-PYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSF 465 Score = 43.5 bits (101), Expect = 5e-04 Identities = 25/80 (31%), Positives = 44/80 (55%), Gaps = 1/80 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++ETLR++ A+ + R D+ + ++IPK A+ + +HRD ++W E Sbjct: 356 LDMVVNETLRMFPIAVRLDRLCKKDVEIHGVSIPKGTAVTVPIFVLHRDPQLWPE----- 410 Query: 421 QPDEVR-ERGRESGQGSARP 365 P+E R ER + + S P Sbjct: 411 -PEEFRPERFSKKNKDSINP 429
>CP341_MOUSE (Q9JMA7) Cytochrome P450 3A41 (EC 1.14.14.1)| Length = 504 Score = 43.9 bits (102), Expect = 4e-04 Identities = 21/55 (38%), Positives = 31/55 (56%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F P RF+ + + P+ + F IGPR CIG FA + K + V+Q FSF Sbjct: 413 EEFQPERFSKE-NKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSF 466 Score = 40.4 bits (93), Expect = 0.004 Identities = 26/80 (32%), Positives = 42/80 (52%), Gaps = 1/80 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MVL+ETLRLY ++R D+ + + IPK ++I + +H D + W E Sbjct: 357 LDMVLNETLRLYPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWPE----- 411 Query: 421 QPDEVR-ERGRESGQGSARP 365 P+E + ER + +GS P Sbjct: 412 -PEEFQPERFSKENKGSIDP 430
>CP3AS_BOVIN (P79102) Cytochrome P450 3A28 (EC 1.14.14.1) (CYPIIIA28)| Length = 507 Score = 43.9 bits (102), Expect = 4e-04 Identities = 20/55 (36%), Positives = 30/55 (54%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F P RF+ + P+ L F GPR C+G FA++ K + +LQ FSF Sbjct: 412 EEFRPERFSKNNKDSIN-PYVYLPFGTGPRNCLGMRFAIMNIKLALVRILQNFSF 465 Score = 39.3 bits (90), Expect = 0.009 Identities = 23/80 (28%), Positives = 44/80 (55%), Gaps = 1/80 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++ETLR++ A ++R D+ + +TIPK +++ +H + ++W E Sbjct: 356 LDMVVNETLRMFPIAGRLERVCKKDVEIHGVTIPKGTTVLVPLFVLHNNPELWPE----- 410 Query: 421 QPDEVR-ERGRESGQGSARP 365 P+E R ER ++ + S P Sbjct: 411 -PEEFRPERFSKNNKDSINP 429
>C4D14_DROME (O46051) Probable cytochrome P450 4d14 (EC 1.14.-.-) (CYPIVD14)| Length = 507 Score = 43.9 bits (102), Expect = 4e-04 Identities = 24/54 (44%), Positives = 35/54 (64%), Gaps = 1/54 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 ++F P RF+ + R ++ P A FS GPR CIGQ FAMLE KS ++ +++ F Sbjct: 424 EKFIPDRFS--MERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHF 475
>CP1A1_LIMLI (O42430) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1)| Length = 521 Score = 37.4 bits (85), Expect(2) = 5e-04 Identities = 26/82 (31%), Positives = 40/82 (48%), Gaps = 2/82 (2%) Frame = -1 Query: 423 FNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 FNP RF A+G ++AF +G R CIG+ A E +A ++QK F Sbjct: 432 FNPDRFLSADGSEVNKLDGEKVMAFGMGKRRCIGEVIARNEVYLFLAILIQKLHF----- 486 Query: 249 YVHAPADFLTLQPKFGLPVVMK 184 + P + L + P++GL + K Sbjct: 487 -LPIPGEKLDMTPEYGLTMKHK 507 Score = 25.4 bits (54), Expect(2) = 5e-04 Identities = 13/42 (30%), Positives = 21/42 (50%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 TT D + IPK+ + I ++ D ++W +D S PD Sbjct: 395 TTKDTSLNGYFIPKDTCVFINQWQINHDPEMW-KDPSSFNPD 435
>CP17A_MESAU (P70687) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 511 Score = 32.7 bits (73), Expect(2) = 5e-04 Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 1/54 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 D+F P RF + P + L F G R+CIG+ A E MA +LQ+F Sbjct: 410 DRFMPERFLDPTGSHLITPSLSYLPFGAGARSCIGEVLARQELFLFMAHLLQRF 463 Score = 30.0 bits (66), Expect(2) = 5e-04 Identities = 14/52 (26%), Positives = 27/52 (51%), Gaps = 1/52 (1%) Frame = -3 Query: 589 LHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 + E LR+ A + + + +DM +G +IPK ++I +H +K W + Sbjct: 357 IREVLRIRPVAPMLIPHRANSDMSIGEFSIPKFTPVIINLWALHHSEKEWDQ 408
>CP2DR_MESAU (Q9QYG6) Cytochrome P450 2D27 (EC 1.14.14.-) (CYPIID27)| Length = 500 Score = 40.8 bits (94), Expect(2) = 5e-04 Identities = 28/77 (36%), Positives = 40/77 (51%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P F + R K A + FS G RAC+G+ A +E +LQ+FSF++ P+ Sbjct: 418 FHPEHFLDAQGRFVK-HEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSV-PAGQ 475 Query: 243 HAPADFLTLQPKFGLPV 193 P+D Q F LPV Sbjct: 476 PRPSD----QGIFALPV 488 Score = 21.9 bits (45), Expect(2) = 5e-04 Identities = 14/51 (27%), Positives = 24/51 (47%), Gaps = 1/51 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+HE R A + + T+ D+ V IPK ++ + +D+ VW Sbjct: 362 VIHEVQRFGDIAPVNIPHMTSHDVEVQGFLIPKGTTLIPNLSSVLKDETVW 412
>CP3AJ_CAPAE (P79152) Cytochrome P450 3A19 (EC 1.14.14.1) (CYPIIIA19) (Fragment)| Length = 218 Score = 43.5 bits (101), Expect = 5e-04 Identities = 20/55 (36%), Positives = 29/55 (52%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F P RF+ P+ L F GPR C+G FA++ K + +LQ FSF Sbjct: 123 EEFRPERFSKKNKDGIN-PYVYLPFGTGPRNCVGMRFALMNIKLALVRILQNFSF 176 Score = 35.0 bits (79), Expect = 0.17 Identities = 21/80 (26%), Positives = 41/80 (51%), Gaps = 1/80 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++ETLR++ A ++R D+ + ++IPK +++ +H + + W E Sbjct: 67 LDMVVNETLRMFPIAGRLERLCKKDVEIHGVSIPKGTTVMVPLFVLHNNPEFWPE----- 121 Query: 421 QPDEVR-ERGRESGQGSARP 365 P+E R ER + + P Sbjct: 122 -PEEFRPERFSKKNKDGINP 140
>CP52Q_CANMA (Q12587) Cytochrome P450 52C2 (EC 1.14.14.-) (CYPLIIC2)| (Alkane-inducible P450-ALK6-A) Length = 510 Score = 43.5 bits (101), Expect = 5e-04 Identities = 21/45 (46%), Positives = 28/45 (62%) Frame = -1 Query: 369 ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAP 235 A + FS GPR C+GQ FA++EA V ++Q FS S S +AP Sbjct: 447 AFMPFSTGPRMCLGQQFALIEASYVTIRLVQTFSKLKSHSLEYAP 491
>CP1A1_FELCA (Q5KQT7) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1)| Length = 517 Score = 33.5 bits (75), Expect(2) = 6e-04 Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 1/57 (1%) Frame = -1 Query: 426 QFNPMRFANGVARAAK-VPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F P RF K + ++ F +G R CIG+ A LE +A +LQ+ F++ Sbjct: 431 EFRPERFLTPDGTINKALSEKVILFGLGKRKCIGETIARLEVFLFLAILLQQVEFSV 487 Score = 28.9 bits (63), Expect(2) = 6e-04 Identities = 11/34 (32%), Positives = 19/34 (55%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 TT D + IPKE + + ++ D+K+WG+ Sbjct: 395 TTKDTSLSGFYIPKERCVFVNQWQINHDQKLWGD 428
>CP2DA_RAT (P12939) Cytochrome P450 2D10 (EC 1.14.14.1) (CYPIID10) (P450-DB5)| (P450-CMF1B) (Debrisoquine 4-hydroxylase) Length = 504 Score = 35.0 bits (79), Expect(2) = 6e-04 Identities = 19/56 (33%), Positives = 29/56 (51%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F+P F + K A + FS G RAC+G+ A +E +LQ FSF++ Sbjct: 417 RFHPEHFLDAQGNFVK-HEAFMPFSAGRRACLGEPLARMELFLFFTCLLQHFSFSV 471 Score = 27.3 bits (59), Expect(2) = 6e-04 Identities = 17/51 (33%), Positives = 26/51 (50%), Gaps = 1/51 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+HE R A L + R T+ D+ V IPK ++I + +D+ VW Sbjct: 362 VIHEVQRFGDIAPLNLPRITSCDIEVQDFVIPKGTTLIINLSSVLKDETVW 412
>CP2D3_RAT (P12938) Cytochrome P450 2D3 (EC 1.14.14.1) (CYPIID3) (P450-DB3)| (Debrisoquine 4-hydroxylase) Length = 500 Score = 38.1 bits (87), Expect(2) = 6e-04 Identities = 22/67 (32%), Positives = 36/67 (53%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 +F+P F + K A + FS G RAC+G+ A +E +LQ+FSF++ P+ Sbjct: 417 RFHPEHFLDAQGNFVK-HEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSV-PTG 474 Query: 246 VHAPADF 226 P+D+ Sbjct: 475 QPRPSDY 481 Score = 24.3 bits (51), Expect(2) = 6e-04 Identities = 14/51 (27%), Positives = 24/51 (47%), Gaps = 1/51 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+HE R + + KT+ D+ V IPK ++ + +D+ VW Sbjct: 362 VIHEVQRFADIVPMNLPHKTSRDIEVQGFLIPKGTTLIPNLSSVLKDETVW 412
>CP2DP_PIG (O46658) Cytochrome P450 2D25 (EC 1.14.14.-) (CYPIID25) (Vitamin| D(3) 25-hydroxylase) Length = 499 Score = 38.5 bits (88), Expect(2) = 6e-04 Identities = 23/66 (34%), Positives = 35/66 (53%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 +F P F + R K A + FS G R+C+G+ A +E T+LQ FSF++ P+ Sbjct: 416 RFYPEHFLDAQGRFTK-QEAFMPFSAGRRSCLGEPLARMELFLFFTTLLQAFSFSV-PTG 473 Query: 246 VHAPAD 229 P+D Sbjct: 474 QPCPSD 479 Score = 23.9 bits (50), Expect(2) = 6e-04 Identities = 16/52 (30%), Positives = 25/52 (48%), Gaps = 2/52 (3%) Frame = -3 Query: 592 VLHETLRLYGPA--LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 VLHE R +G L + T+ D+ V IPK ++ + +D+ VW Sbjct: 361 VLHEVQR-FGDIVPLGVAHMTSCDIEVQGFLIPKGTTLITNLTSVLKDETVW 411
>C80B2_ESCCA (O64900) (S)-N-methylcoclaurine 3'-hydroxylase isozyme 2 (EC| 1.14.13.71) (Cytochrome P450 80B2) Length = 488 Score = 32.0 bits (71), Expect(2) = 6e-04 Identities = 18/48 (37%), Positives = 26/48 (54%), Gaps = 1/48 (2%) Frame = -3 Query: 583 ETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 ETLRL+ P L + R+ + TIPK+ I++ A + RD K W Sbjct: 348 ETLRLHPPTPLLLPRRALETCTILNYTIPKDCQIMVNAWGIGRDPKTW 395 Score = 30.4 bits (67), Expect(2) = 6e-04 Identities = 22/75 (29%), Positives = 31/75 (41%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RF N +L+ F G R C G A ++AT +Q + L Sbjct: 401 FSPERFLNSSVDFRGNDFSLIPFGAGRRICPGLPIANQFIALLVATFVQNLDWCLPNG-- 458 Query: 243 HAPADFLTLQPKFGL 199 D L ++ KFGL Sbjct: 459 -MSVDHLIVEEKFGL 472
>C80B1_ESCCA (O64899) (S)-N-methylcoclaurine 3'-hydroxylase isozyme 1 (EC| 1.14.13.71) (Cytochrome P450 80B1) (Fragment) Length = 487 Score = 32.0 bits (71), Expect(2) = 6e-04 Identities = 18/48 (37%), Positives = 26/48 (54%), Gaps = 1/48 (2%) Frame = -3 Query: 583 ETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 ETLRL+ P L + R+ + TIPK+ I++ A + RD K W Sbjct: 347 ETLRLHPPTPLLLPRRALETCTILNYTIPKDCQIMVNAWGIGRDPKTW 394 Score = 30.4 bits (67), Expect(2) = 6e-04 Identities = 22/75 (29%), Positives = 31/75 (41%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P RF N +L+ F G R C G A ++AT +Q + L Sbjct: 400 FSPERFLNSSVDFRGNDFSLIPFGAGRRICPGLPIANQFIALLVATFVQNLDWCLPNG-- 457 Query: 243 HAPADFLTLQPKFGL 199 D L ++ KFGL Sbjct: 458 -MSVDHLIVEEKFGL 471
>CP9B2_DROME (Q9V4I1) Cytochrome P450 9b2 (EC 1.14.-.-) (CYPIXB2)| Length = 505 Score = 43.1 bits (100), Expect = 6e-04 Identities = 19/58 (32%), Positives = 33/58 (56%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 +F+P RF+ + VP+ L F +GPR CIG +A+++ K ++ +L + SP Sbjct: 420 KFDPDRFSEE-RKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASP 476
>CP3AB_MOUSE (Q64459) Cytochrome P450 3A11 (EC 1.14.14.1) (CYPIIIA11)| (P-450IIIAM1) (P-450UT) Length = 504 Score = 43.1 bits (100), Expect = 6e-04 Identities = 27/80 (33%), Positives = 43/80 (53%), Gaps = 1/80 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MVL+ETLRLY A ++R D+ + + IPK ++I + +H D + W E Sbjct: 357 LDMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSE----- 411 Query: 421 QPDEVR-ERGRESGQGSARP 365 P+E + ER + +GS P Sbjct: 412 -PEEFQPERFSKENKGSIDP 430 Score = 42.4 bits (98), Expect = 0.001 Identities = 19/55 (34%), Positives = 31/55 (56%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 ++F P RF+ + + P+ L F GPR C+G FA++ K + ++Q FSF Sbjct: 413 EEFQPERFSKE-NKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSF 466
>CP2AC_MOUSE (P56593) Cytochrome P450 2A12 (EC 1.14.14.1) (CYPIIA12) (Steroid| hormones 7-alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase) Length = 492 Score = 43.1 bits (100), Expect = 6e-04 Identities = 26/83 (31%), Positives = 37/83 (44%), Gaps = 5/83 (6%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 FNP F + + K+P A L FS G R C+G + A +E + T+LQ F F Sbjct: 409 FNPQHFLDDKGQLKKIP-AFLPFSTGKRFCLGDSLAKMELFFLFTTILQNFRFKFPRKLE 467 Query: 243 H-----APADFLTLQPKFGLPVV 190 P F + PK+ + V Sbjct: 468 DINESPTPEGFTRIIPKYTMSFV 490
>CCD1D_DROME (Q7KR10) Probable cytochrome P450 12d1 distal, mitochondrial| precursor (EC 1.14.-.-) (CYPXIID1) Length = 521 Score = 35.0 bits (79), Expect(2) = 8e-04 Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 3/56 (5%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKV---PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 D+F P R+ K+ P L F GPR CIG+ LE ++ +A +++ F Sbjct: 433 DEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNF 488 Score = 26.9 bits (58), Expect(2) = 8e-04 Identities = 11/46 (23%), Positives = 23/46 (50%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRD 455 V+ ETLR Y R D+++ +PK +++G+ + ++ Sbjct: 380 VIKETLRYYPNGFGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKE 425
>CPXH_STRGR (P26911) Cytochrome P450-SOY (EC 1.14.-.-)| Length = 412 Score = 31.6 bits (70), Expect(2) = 8e-04 Identities = 18/51 (35%), Positives = 25/51 (49%) Frame = -3 Query: 595 MVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 +V+ E LR A +QR T DM V TI K +V ++RD V+ Sbjct: 286 VVVEELLRFLSIAEGLQRLATEDMEVDGATIRKGEGVVFSTSLINRDADVF 336 Score = 30.4 bits (67), Expect(2) = 8e-04 Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 4/61 (6%) Frame = -1 Query: 363 LAFSIGPRACIGQNFAMLEAKSVMATVLQK---FSFALSPSYV-HAPADFLTLQPKFGLP 196 LAF G C+GQN A E M T+ ++ A+ + H P D T+Q LP Sbjct: 352 LAFGFGVHQCLGQNLARAELDIAMRTLFERLPGLRLAVPAHEIRHKPGD--TIQGLLDLP 409 Query: 195 V 193 V Sbjct: 410 V 410
>CP2BB_CANFA (P24460) Cytochrome P450 2B11 (EC 1.14.14.1) (CYPIIB11) (P450| PBD-2) Length = 494 Score = 42.7 bits (99), Expect = 8e-04 Identities = 26/58 (44%), Positives = 31/58 (53%), Gaps = 2/58 (3%) Frame = -1 Query: 429 DQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 262 D FNP F ANG A K A + FSIG R C+G+ A +E T+LQ FS A Sbjct: 406 DVFNPDHFLDANG---ALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVA 460
>CP2B9_MOUSE (P12790) Cytochrome P450 2B9 (EC 1.14.14.1) (CYPIIB9) (Testosterone| 16-alpha hydroxylase) (P450-16-alpha) (Clone PF26) Length = 491 Score = 42.7 bits (99), Expect = 8e-04 Identities = 34/76 (44%), Positives = 41/76 (53%), Gaps = 2/76 (2%) Frame = -1 Query: 429 DQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 256 D+FNP +F ANG A K A L FS G R C+G++ A E T+LQ FS A S Sbjct: 406 DKFNPEQFLDANG---ALKKCEAFLPFSTGKRICLGESIARNELFIFFTTILQNFSVA-S 461 Query: 255 PSYVHAPADFLTLQPK 208 P AP D + L PK Sbjct: 462 PV---APKD-IDLTPK 473
>CP4F2_HUMAN (P78329) Cytochrome P450 4F2 (EC 1.14.13.30) (CYPIVF2)| (Leukotriene-B(4) omega-hydroxylase) (Leukotriene-B(4) 20-monooxygenase) (Cytochrome P450-LTB-omega) Length = 520 Score = 42.7 bits (99), Expect = 8e-04 Identities = 23/51 (45%), Positives = 30/51 (58%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 ++P RF + + P A + FS GPR CIGQ FAM E K V+A L +F Sbjct: 440 YDPFRFDPENIKE-RSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRF 489 Score = 33.9 bits (76), Expect = 0.38 Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 5/73 (6%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGE---- 437 +TM + E+LRL+ P + R T D+V+ IPK +I H + VW + Sbjct: 381 LTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVY 440 Query: 436 DAGSVQPDEVRER 398 D P+ ++ER Sbjct: 441 DPFRFDPENIKER 453
>CP19A_ICTPU (Q92111) Cytochrome P450 19A1 (EC 1.14.14.1) (Aromatase) (CYPXIX)| (Estrogen synthetase) (P-450AROM) Length = 524 Score = 35.4 bits (80), Expect(2) = 0.001 Identities = 14/30 (46%), Positives = 22/30 (73%) Frame = -1 Query: 357 FSIGPRACIGQNFAMLEAKSVMATVLQKFS 268 F GPR+C+G++ AM+ K+V+ VL +FS Sbjct: 450 FGSGPRSCVGKHIAMVMMKAVLLMVLSRFS 479 Score = 26.2 bits (56), Expect(2) = 0.001 Identities = 12/46 (26%), Positives = 22/46 (47%) Frame = -3 Query: 589 LHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDK 452 ++E LR + F R+ D V+ +P+ I++ MHR + Sbjct: 380 INEALRFHPVVDFSYRRALDDDVIEGFRVPRGTNIILNVGRMHRSE 425
>C93B1_GLYEC (P93149) Cytochrome P450 93B1 (EC 1.14.13.87) (Licodione synthase)| ((2S)-flavanone 2-hydroxylase) (Flavone synthase II) (CYP GE-5) Length = 523 Score = 32.3 bits (72), Expect(2) = 0.001 Identities = 19/60 (31%), Positives = 28/60 (46%), Gaps = 6/60 (10%) Frame = -1 Query: 426 QFNPMRF------ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 +F P RF ++GV LL F G R C G + AM E +++ ++Q F F Sbjct: 412 EFRPERFLKLEGDSSGVVDVRGSHFQLLPFGSGRRMCPGVSLAMQEVPALLGAIIQCFDF 471 Score = 29.3 bits (64), Expect(2) = 0.001 Identities = 13/50 (26%), Positives = 24/50 (48%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 +L ET RL+ P + R+ + V IP++ + + + R+ K W Sbjct: 358 ILKETFRLHPPVPMVTRRCVAECTVENYVIPEDSLLFVNVWSIGRNPKFW 407
>CP1A1_LIZAU (O42231) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1)| Length = 521 Score = 37.4 bits (85), Expect(2) = 0.001 Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 2/82 (2%) Frame = -1 Query: 423 FNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 FNP RF A+G ++ F +G R CIG+ A E +A ++QK F Sbjct: 432 FNPDRFLSADGTEVNKVDGEKVMVFGLGKRRCIGEVIARNEVYMFLAILIQKLHF----- 486 Query: 249 YVHAPADFLTLQPKFGLPVVMK 184 + P + L + P++GL + K Sbjct: 487 -YNLPGEPLDMTPEYGLTMKHK 507 Score = 24.3 bits (51), Expect(2) = 0.001 Identities = 13/42 (30%), Positives = 21/42 (50%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 TT D + IPK+ + I ++ D ++W E + S PD Sbjct: 395 TTKDTSLNGYYIPKDTCVFINQWQINHDPELWKEPS-SFNPD 435
>C4AD1_DROME (Q9V4T3) Probable cytochrome P450 4ad1 (EC 1.14.-.-) (CYPIVAD1)| Length = 516 Score = 40.8 bits (94), Expect(2) = 0.001 Identities = 18/51 (35%), Positives = 28/51 (54%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 F P RF N + FS GPR CI + FAM + K++++ +L++F Sbjct: 416 FRPERFENPTGNVGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRF 466 Score = 20.8 bits (42), Expect(2) = 0.001 Identities = 12/63 (19%), Positives = 30/63 (47%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + +++ ETLRLY + R + + + K +++ M ++K + +D + Sbjct: 358 LELIIRETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYF-DDPCTF 416 Query: 421 QPD 413 +P+ Sbjct: 417 RPE 419
>CP1A2_CANFA (P56592) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (DAH2)| (Cytochrome P450-D2) Length = 511 Score = 33.9 bits (76), Expect(2) = 0.001 Identities = 24/89 (26%), Positives = 40/89 (44%), Gaps = 14/89 (15%) Frame = -1 Query: 423 FNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA---- 262 F P RF A+G + ++ F +G R CIG+ A E +A +LQ+ F+ Sbjct: 422 FRPERFLTADGTTINKTLSEKVMLFGMGKRRCIGEVLAKWEIFLFLAILLQRLEFSVPAG 481 Query: 261 ----LSPSY----VHAPADFLTLQPKFGL 199 L+P Y H + + +P+F + Sbjct: 482 VKVDLTPIYGLTMKHTRCEHVQARPRFSI 510 Score = 27.7 bits (60), Expect(2) = 0.001 Identities = 12/34 (35%), Positives = 19/34 (55%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 TT D + IPKE + I ++ D++VWG+ Sbjct: 385 TTKDTTLKGFYIPKECCVFINQWQVNHDQQVWGD 418
>CP2DA_MOUSE (P24456) Cytochrome P450 2D10 (EC 1.14.14.1) (CYPIID10)| (P450-16-alpha) (P450CB) (Testosterone 16-alpha hydroxylase) Length = 504 Score = 37.4 bits (85), Expect(2) = 0.001 Identities = 19/56 (33%), Positives = 30/56 (53%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F+P F + K P A + FS G R+C+G+ A +E +LQ FSF++ Sbjct: 417 RFHPEHFLDAQGHFVK-PEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQHFSFSV 471 Score = 24.3 bits (51), Expect(2) = 0.001 Identities = 16/51 (31%), Positives = 25/51 (49%), Gaps = 1/51 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+HE R A L + R T+ D+ V IPK ++ + +D+ VW Sbjct: 362 VIHEVQRFGDIAPLNLPRITSRDIEVQDFLIPKGSILIPNMSSVLKDETVW 412
>CPXP_BRAJA (Q59203) Cytochrome P450 BJ-1 (EC 1.14.14.-) (Cytochrome P450 112)| Length = 401 Score = 36.2 bits (82), Expect(2) = 0.001 Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 3/55 (5%) Frame = -1 Query: 375 PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQK---FSFALSPSYVHAPADFLT 220 PH LAFS GP ACIG A LE K V ++ Q+ A++P + + +T Sbjct: 339 PH--LAFSYGPHACIGVALARLELKVVFGSIFQRLPALRLAVAPEQLKLRKEIIT 391 Score = 25.4 bits (54), Expect(2) = 0.001 Identities = 13/43 (30%), Positives = 21/43 (48%), Gaps = 3/43 (6%) Frame = -3 Query: 589 LHETLRLYGPALF---MQRKTTTDMVVGAITIPKEHAIVIGAP 470 + E LR+Y P + R TD+ + IP E +++G P Sbjct: 274 VEEILRMYPPGAGWDGIMRYPRTDVTIAGEHIPAESKVLVGLP 316
>C4AC1_DROME (Q9VMS9) Probable cytochrome P450 4ac1 (EC 1.14.-.-) (CYPIVAC1)| Length = 509 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/55 (47%), Positives = 32/55 (58%), Gaps = 2/55 (3%) Frame = -1 Query: 429 DQFNPMRFA--NGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 D F P RF N V R P A + FS G R CIGQ FA+LE K ++A V++ F Sbjct: 424 DLFQPDRFLPENTVNRH---PFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNF 475
>CP2DJ_CALJA (O18992) Cytochrome P450 2D19 (EC 1.14.14.1) (CYPIID19) (P450| CM2D-1) Length = 497 Score = 42.4 bits (98), Expect = 0.001 Identities = 22/56 (39%), Positives = 32/56 (57%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F+P F + R K P A L FS G RAC+G+ A +E +LQ+FSF++ Sbjct: 414 RFHPEHFLDAQGRFVK-PEAFLPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSV 468
>CP4FB_HUMAN (Q9HBI6) Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11)| Length = 524 Score = 42.4 bits (98), Expect = 0.001 Identities = 24/51 (47%), Positives = 29/51 (56%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 ++P RF N + P A + FS GPR CIGQ FAM E K V+A L F Sbjct: 440 YDPFRF-NQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHF 489 Score = 29.6 bits (65), Expect = 7.1 Identities = 21/73 (28%), Positives = 34/73 (46%), Gaps = 5/73 (6%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGE---- 437 +TM + E+LRL+ P + R T D V+ IPK +I +H + VW + Sbjct: 381 LTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVY 440 Query: 436 DAGSVQPDEVRER 398 D + ++ER Sbjct: 441 DPFRFNQENIKER 453
>CP1A1_MESAU (Q00557) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P-450MC)| Length = 524 Score = 36.6 bits (83), Expect(2) = 0.001 Identities = 20/60 (33%), Positives = 29/60 (48%), Gaps = 1/60 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLA-FSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 ++F P RF KV + F +G R CIG+ LE +A +LQ+ F +SP Sbjct: 429 NKFRPERFLTSSGTLDKVLSGKVTLFGLGKRKCIGETIGRLEVFLFLAILLQQIEFTVSP 488 Score = 24.6 bits (52), Expect(2) = 0.001 Identities = 9/34 (26%), Positives = 19/34 (55%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 TT D + IPK H + + ++ ++++WG+ Sbjct: 394 TTRDTSLCGFYIPKGHCVFVNQWQINHNQELWGD 427
>CP17A_RANDY (O57525) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 519 Score = 31.6 bits (70), Expect(2) = 0.001 Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 1/81 (1%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 F+P RF + P + L F G R C+G+ A +E ++ +LQ+F+ + P Sbjct: 425 FSPDRFLDENGNRVYSPSPSFLPFGAGIRVCLGEALAKMEVFLFLSWILQRFTLEV-PEG 483 Query: 246 VHAPADFLTLQPKFGLPVVMK 184 P L+ KFG+ + +K Sbjct: 484 DPLP----DLEGKFGVVIQVK 500 Score = 29.6 bits (65), Expect(2) = 0.001 Identities = 12/26 (46%), Positives = 16/26 (61%) Frame = -3 Query: 520 VGAITIPKEHAIVIGAPFMHRDKKVW 443 +G TIPKE +VI +H D+K W Sbjct: 394 IGEYTIPKEARVVINLWSLHHDEKEW 419
>CP1A2_HUMAN (P05177) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450-P3)| (P(3)450) (P450 4) Length = 514 Score = 37.0 bits (84), Expect(2) = 0.001 Identities = 20/60 (33%), Positives = 32/60 (53%), Gaps = 2/60 (3%) Frame = -1 Query: 426 QFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 +F P RF A+G A + ++ F +G R CIG+ A E +A +LQ+ F++ P Sbjct: 425 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 484 Score = 24.3 bits (51), Expect(2) = 0.001 Identities = 11/42 (26%), Positives = 21/42 (50%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 TT D + IPK+ + + ++ D ++W ED +P+ Sbjct: 389 TTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW-EDPSEFRPE 429
>CP3AI_RAT (Q64581) Cytochrome P450 3A18 (EC 1.14.14.1) (CYPIIIA18)| (P450(6)beta-2) Length = 497 Score = 42.0 bits (97), Expect = 0.001 Identities = 21/54 (38%), Positives = 31/54 (57%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 268 ++FNP RF+ + + P+ L F GPR CIG FA++ K + VLQ F+ Sbjct: 412 EEFNPERFSKE-NKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFN 464 Score = 39.3 bits (90), Expect = 0.009 Identities = 24/80 (30%), Positives = 42/80 (52%), Gaps = 1/80 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++E+LRLY A + R + D+ + + IPK + I +HR+ + W + Sbjct: 356 LDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGTVVTIPIYPLHRNPEYW------L 409 Query: 421 QPDEVR-ERGRESGQGSARP 365 +P+E ER + +GS P Sbjct: 410 EPEEFNPERFSKENKGSIDP 429
>C81F1_ARATH (O65790) Cytochrome P450 81F1 (EC 1.14.-.-)| Length = 500 Score = 42.0 bits (97), Expect = 0.001 Identities = 21/65 (32%), Positives = 36/65 (55%), Gaps = 1/65 (1%) Frame = -3 Query: 592 VLHETLRLYGPALFM-QRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQP 416 V+ ET RL+ A F+ R T DM +G +P++ +++ A +HRD ++W E+ P Sbjct: 354 VVSETFRLFPVAPFLIPRSPTDDMKIGGYDVPRDTIVMVNAWAIHRDPEIW-EEPEKFNP 412 Query: 415 DEVRE 401 D + Sbjct: 413 DRYND 417
>CP2B6_HUMAN (P20813) Cytochrome P450 2B6 (EC 1.14.14.1) (CYPIIB6) (P450 IIB1)| Length = 491 Score = 42.0 bits (97), Expect = 0.001 Identities = 25/58 (43%), Positives = 30/58 (51%), Gaps = 2/58 (3%) Frame = -1 Query: 429 DQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 262 D FNP F ANG A K A + FS+G R C+G+ A E T+LQ FS A Sbjct: 406 DAFNPDHFLDANG---ALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMA 460
>CP52M_DEBHA (Q9Y758) Cytochrome P450 52A13 (EC 1.14.14.-) (Alkane hydroxylase| 2) (Alkane-inducible p450alk 2) (DH-ALK2) Length = 519 Score = 42.0 bits (97), Expect = 0.001 Identities = 21/53 (39%), Positives = 32/53 (60%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 D+F P R+A + K+ A + F+ GPR C+GQ FA+ EA ++ +LQ F Sbjct: 439 DEFKPERWAE----SRKLGWAYVPFNGGPRICLGQQFALTEASYIVTRLLQMF 487
>CPXN_ANASP (P29980) Probable cytochrome P450 110 (EC 1.14.-.-)| Length = 459 Score = 42.0 bits (97), Expect = 0.001 Identities = 29/81 (35%), Positives = 38/81 (46%), Gaps = 1/81 (1%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 QF P RF P + F G R C+G A+LE K V+ATVL + AL+ Sbjct: 367 QFRPERFIE----RQYSPSEYIPFGGGSRRCLGYALALLEIKLVIATVLSNYQLALAEDK 422 Query: 246 -VHAPADFLTLQPKFGLPVVM 187 V+ TL P G+ V+M Sbjct: 423 PVNVQRRGFTLAPDGGVRVIM 443
>CP9F2_DROME (Q9VG82) Probable cytochrome P450 9f2 (EC 1.14.-.-) (CYPIXF2)| Length = 516 Score = 42.0 bits (97), Expect = 0.001 Identities = 21/55 (38%), Positives = 34/55 (61%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 262 +F+P RF++ + + P F +G R CIG FA+LEAK+V+ +L+ + FA Sbjct: 431 KFDPERFSDENKESIQ-PFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFA 484
>CP4P2_DROME (Q9V557) Probable cytochrome P450 4p2 (EC 1.14.-.-) (CYPIVP2)| Length = 520 Score = 42.0 bits (97), Expect = 0.001 Identities = 23/55 (41%), Positives = 33/55 (60%), Gaps = 2/55 (3%) Frame = -1 Query: 429 DQFNPMRFA--NGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 ++F P RF N + R P+A + FS G R CIGQ +AM E K++M +L+ F Sbjct: 434 EEFRPERFLPQNCLKRH---PYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHF 485
>C12B1_DROAC (O44220) Cytochrome P450 12b1, mitochondrial precursor (EC| 1.14.-.-) (CYPXIIB1) Length = 532 Score = 37.0 bits (84), Expect(2) = 0.002 Identities = 15/41 (36%), Positives = 26/41 (63%) Frame = -1 Query: 393 ARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 A ++ P LAF GPR CIG+ A LE ++++ +L+++ Sbjct: 461 AARSRNPFVYLAFGFGPRTCIGKRIAELEMETLLTRLLRRY 501 Score = 23.9 bits (50), Expect(2) = 0.002 Identities = 10/44 (22%), Positives = 23/44 (52%) Frame = -3 Query: 544 RKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 R T D+V+ +P+ +++G + +K +G+ +G P+ Sbjct: 403 RIATKDLVLSGYRVPRGEGVLMGVLELSNSEKYFGQ-SGQFMPE 445
>CP1A1_LIZSA (Q9W683) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1)| Length = 521 Score = 36.6 bits (83), Expect(2) = 0.002 Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 2/82 (2%) Frame = -1 Query: 423 FNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 FNP RF A+G ++ F +G R CIG+ A E +A ++QK F Sbjct: 432 FNPDRFLSADGTEVNKVDGEKVMIFGMGKRRCIGEVIARNEVYLFLAILIQKLHFC---- 487 Query: 249 YVHAPADFLTLQPKFGLPVVMK 184 + P + L + P++GL + K Sbjct: 488 --NLPGEPLDMTPEYGLTMKHK 507 Score = 24.3 bits (51), Expect(2) = 0.002 Identities = 13/42 (30%), Positives = 21/42 (50%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 TT D + IPK+ + I ++ D ++W E + S PD Sbjct: 395 TTKDTSLNGYYIPKDTCVFINQWQINHDPELWKEPS-SFNPD 435
>CP2D9_MOUSE (P11714) Cytochrome P450 2D9 (EC 1.14.14.1) (CYPIID9)| (P450-16-alpha) (CA) (Testosterone 16-alpha hydroxylase) Length = 504 Score = 38.5 bits (88), Expect(2) = 0.002 Identities = 19/56 (33%), Positives = 31/56 (55%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F+P F + K P A + FS G R+C+G+ A +E +LQ+FSF++ Sbjct: 417 RFHPEHFLDAQGHFVK-PEAFMPFSAGRRSCLGEALARMELFLFFTCLLQRFSFSV 471 Score = 22.3 bits (46), Expect(2) = 0.002 Identities = 16/52 (30%), Positives = 26/52 (50%), Gaps = 2/52 (3%) Frame = -3 Query: 592 VLHETLRLYGPAL--FMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+HE R +G + + R T+ D+ V IPK ++ M +D+ VW Sbjct: 362 VIHEVQR-FGDIVPVNLPRITSHDIEVQDFLIPKGTILLPNMSSMLKDESVW 412
>CYPD_BACSU (O08394) Probable bifunctional P-450:NADPH-P450 reductase 1| [Includes: Cytochrome P450 102 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)] Length = 1061 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 1/82 (1%) Frame = -1 Query: 453 RRSGARTRDQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQ 277 R + + ++F P RF + +VPH A F G RACIG FA+ EA V+ +L+ Sbjct: 367 RDAWGKDAEEFRPERFEH----QDQVPHHAYKPFGNGQRACIGMQFALHEATLVLGMILK 422 Query: 276 KFSFALSPSYVHAPADFLTLQP 211 F+ +Y LTL+P Sbjct: 423 YFTLIDHENYELDIKQTLTLKP 444 Score = 39.7 bits (91), Expect = 0.007 Identities = 22/63 (34%), Positives = 35/63 (55%), Gaps = 2/63 (3%) Frame = -3 Query: 595 MVLHETLRLY--GPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 M+L+E+LRL+ PA + K T ++ G I I + P +HRD+ WG+DA Sbjct: 319 MILNESLRLWPTAPAFSLYPKEDT-VIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEF 377 Query: 421 QPD 413 +P+ Sbjct: 378 RPE 380
>CP3AA_MESAU (Q64148) Cytochrome P450 3A10 (EC 1.14.13.94) (CYPIIIA10)| (Lithocholate 6-beta-hydroxylase) (6 beta-hydroxylase) Length = 503 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/86 (31%), Positives = 46/86 (53%), Gaps = 2/86 (2%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF-ALSP 253 ++F P RF+ + + P+ + F GPR CIG FA+L K + +VLQ F+ Sbjct: 412 EEFRPERFSKE-NKGSIDPYVYMPFGNGPRNCIGMRFALLSMKLAVVSVLQNFTLQTCEQ 470 Query: 252 SYVHAP-ADFLTLQPKFGLPVVMKLL 178 + H A + LQP+ P+++K++ Sbjct: 471 TENHLKFARQIILQPE--NPIILKII 494 Score = 38.5 bits (88), Expect = 0.015 Identities = 25/80 (31%), Positives = 42/80 (52%), Gaps = 1/80 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++E LRLY A ++R + + + + IPK +++ +HRD + W E Sbjct: 356 LDMVINEGLRLYPIANRLERISKKAVEINGLFIPKGITVMVPTYPLHRDPEYWPE----- 410 Query: 421 QPDEVR-ERGRESGQGSARP 365 P+E R ER + +GS P Sbjct: 411 -PEEFRPERFSKENKGSIDP 429
>CP3AV_MESAU (O70537) Cytochrome P450 3A31 (EC 1.14.14.1) (CYPIIIA31) (P450| SH3A-1) Length = 501 Score = 41.6 bits (96), Expect = 0.002 Identities = 21/54 (38%), Positives = 30/54 (55%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 268 ++F P RF+ + + P+ L F GPR CIG FA++ K + VLQ FS Sbjct: 410 EKFRPERFSKE-NKGSIDPYIFLPFGNGPRNCIGMRFALMNMKLALTKVLQNFS 462 Score = 39.3 bits (90), Expect = 0.009 Identities = 26/89 (29%), Positives = 43/89 (48%), Gaps = 1/89 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MVL+ETLRLY ++R D+ + + +PK +++ +H D + W E Sbjct: 354 LDMVLNETLRLYPIGSRLERVCKQDVEMDGVFVPKGSIVMVPVFALHYDPQYWPE----- 408 Query: 421 QPDEVR-ERGRESGQGSARPARILDRAEG 338 P++ R ER + +GS P L G Sbjct: 409 -PEKFRPERFSKENKGSIDPYIFLPFGNG 436
>CP2DS_MESAU (Q9QUJ1) Cytochrome P450 2D28 (EC 1.14.14.-) (CYPIID28)| Length = 500 Score = 37.4 bits (85), Expect(2) = 0.002 Identities = 23/69 (33%), Positives = 36/69 (52%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P F + K A + FS G RAC+G+ A +E +LQ+FSF++ P+ Sbjct: 418 FHPEHFLDAQGCFVK-QEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSV-PAGQ 475 Query: 243 HAPADFLTL 217 P+D + L Sbjct: 476 PRPSDHVVL 484 Score = 23.1 bits (48), Expect(2) = 0.002 Identities = 15/51 (29%), Positives = 24/51 (47%), Gaps = 1/51 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+HE R A L + T+ D+ V IPK ++ + +D+ VW Sbjct: 362 VIHEVQRFADIAPLNLPCITSRDIEVQGFLIPKGTTLITNLSSVLKDETVW 412
>CP17A_PANTR (Q8HYN1) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 41.2 bits (95), Expect = 0.002 Identities = 30/86 (34%), Positives = 40/86 (46%), Gaps = 1/86 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 DQF P RF N P + L F GPR+CIG+ A E +MA +LQ+F + Sbjct: 410 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEV-- 467 Query: 252 SYVHAPADFLTLQPKFGLPVVMKLLD 175 D L G+P V+ L+D Sbjct: 468 ------PDDGQLPSLEGIPKVVFLID 487
>CP17A_HUMAN (P05093) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-monooxygenase) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 41.2 bits (95), Expect = 0.002 Identities = 30/86 (34%), Positives = 40/86 (46%), Gaps = 1/86 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 DQF P RF N P + L F GPR+CIG+ A E +MA +LQ+F + Sbjct: 410 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEV-- 467 Query: 252 SYVHAPADFLTLQPKFGLPVVMKLLD 175 D L G+P V+ L+D Sbjct: 468 ------PDDGQLPSLEGIPKVVFLID 487
>C6A13_DROME (Q9V4U9) Probable cytochrome P450 6a13 (EC 1.14.-.-) (CYPVIA13)| Length = 493 Score = 41.2 bits (95), Expect = 0.002 Identities = 22/58 (37%), Positives = 33/58 (56%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 256 ++F+P RF +A + P A L F GPR CIG+ F L+ K + +L+ F F+ S Sbjct: 405 EKFDPSRFEPEEIKA-RHPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRS 461
>C6A14_DROME (Q9V4U7) Probable cytochrome P450 6a14 (EC 1.14.-.-) (CYPVIA14)| Length = 509 Score = 41.2 bits (95), Expect = 0.002 Identities = 21/58 (36%), Positives = 35/58 (60%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 256 ++F+P RF + + P A L F GPR CIG F ++AK + ++L++F F++S Sbjct: 424 EKFDPSRFDPEEVKN-RHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVS 480
>CP2BJ_MOUSE (O55071) Cytochrome P450 2B19 (EC 1.14.14.1) (CYPIIB19)| Length = 492 Score = 41.2 bits (95), Expect = 0.002 Identities = 25/58 (43%), Positives = 29/58 (50%), Gaps = 2/58 (3%) Frame = -1 Query: 429 DQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 262 D FNP F ANG A K A + FS G R C+G+ A E T+LQ FS A Sbjct: 407 DSFNPEHFLDANG---ALKTNEAFMPFSTGKRICLGEGIARNELFLFFTTILQNFSLA 461
>CP17A_ICTPU (O73853) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 514 Score = 35.4 bits (80), Expect(2) = 0.003 Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 1/53 (1%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 268 FNP RF N + P + L F G R C+G+ A LE ++ +LQ+F+ Sbjct: 415 FNPERFLNEEGNSLCCPSLSYLPFGAGVRVCLGEALAKLELFLFLSWILQRFT 467 Score = 24.6 bits (52), Expect(2) = 0.003 Identities = 12/50 (24%), Positives = 24/50 (48%), Gaps = 1/50 (2%) Frame = -3 Query: 589 LHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 + E LR+ + L + +D +G T+ K +++ +H D+K W Sbjct: 360 IREVLRIRPVSPLLIPHVALSDANIGEYTVQKGTRVIVNLWSLHHDEKEW 409
>CP304_DROME (Q9VG17) Probable cytochrome P450 304a1 (EC 1.14.-.-) (CYPCCCIVA1)| Length = 510 Score = 38.5 bits (88), Expect(2) = 0.003 Identities = 21/60 (35%), Positives = 27/60 (45%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 +QF P RF + + L F G R C G+ FA V AT+ Q F F L P+ Sbjct: 423 EQFRPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPN 482 Score = 21.6 bits (44), Expect(2) = 0.003 Identities = 9/35 (25%), Positives = 15/35 (42%) Frame = -3 Query: 541 KTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 K D + IPK+ +V H D ++W + Sbjct: 387 KALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSD 421
>KO1_ARATH (Q93ZB2) Ent-kaurene oxidase (EC 1.14.13.78) (AtKO1) (Cytochrome| P450 701A3) Length = 509 Score = 32.0 bits (71), Expect(2) = 0.003 Identities = 20/51 (39%), Positives = 23/51 (45%), Gaps = 1/51 (1%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V HETLR Y PA L R D +G +P I I + DKK W Sbjct: 369 VFHETLRKYSPAPLVPIRYAHEDTQIGGYHVPAGSEIAINIYGCNMDKKRW 419 Score = 28.1 bits (61), Expect(2) = 0.003 Identities = 19/69 (27%), Positives = 29/69 (42%) Frame = -1 Query: 465 CTGTRRSGARTRDQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMAT 286 C ++ R D + P RF + H +AF G R C G A L A + Sbjct: 412 CNMDKKRWERPEDWW-PERFLDDGKYETSDLHKTMAFGAGKRVCAGALQASLMAGIAIGR 470 Query: 285 VLQKFSFAL 259 ++Q+F + L Sbjct: 471 LVQEFEWKL 479
>C11B1_SHEEP (P51663) Cytochrome P450 11B1, mitochondrial precursor (EC| 1.14.15.4) (CYPXIB1) (P450C11) (Steroid 11-beta-hydroxylase) Length = 503 Score = 33.1 bits (74), Expect(2) = 0.003 Identities = 16/53 (30%), Positives = 29/53 (54%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 + ++P R+ + ++ PH LAF G R C+G+ A +E ++ VL+ F Sbjct: 421 ESYHPQRWLDRQGSGSRFPH--LAFGFGMRQCLGRRVAEVEMLLLLHHVLKNF 471 Score = 26.9 bits (58), Expect(2) = 0.003 Identities = 12/30 (40%), Positives = 20/30 (66%) Frame = -3 Query: 589 LHETLRLYGPALFMQRKTTTDMVVGAITIP 500 L ETLRLY + ++R+ ++D+V+ IP Sbjct: 369 LKETLRLYPVGITLERQVSSDLVLQNYHIP 398
>C11B1_BOVIN (P15150) Cytochrome P450 11B1, mitochondrial precursor (EC| 1.14.15.4) (CYPXIB1) (P450C11) (Steroid 11-beta-hydroxylase) Length = 503 Score = 33.1 bits (74), Expect(2) = 0.003 Identities = 16/53 (30%), Positives = 29/53 (54%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 + ++P R+ + ++ PH LAF G R C+G+ A +E ++ VL+ F Sbjct: 421 ESYHPQRWLDRQGSGSRFPH--LAFGFGVRQCLGRRVAEVEMLLLLHHVLKNF 471 Score = 26.9 bits (58), Expect(2) = 0.003 Identities = 12/30 (40%), Positives = 20/30 (66%) Frame = -3 Query: 589 LHETLRLYGPALFMQRKTTTDMVVGAITIP 500 L ETLRLY + ++R+ ++D+V+ IP Sbjct: 369 LKETLRLYPVGITLEREVSSDLVLQNYHIP 398
>C71B5_ARATH (O65784) Cytochrome P450 71B5 (EC 1.14.-.-)| Length = 498 Score = 35.8 bits (81), Expect(2) = 0.003 Identities = 23/65 (35%), Positives = 33/65 (50%), Gaps = 1/65 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGS 425 + MV+ E RL+ PA L + R T +D+ + +IPK I I + RD K W Sbjct: 351 LKMVIEEAFRLHPPAPLLLPRLTMSDINIQGYSIPKNTMIQINTYTIGRDPKNW------ 404 Query: 424 VQPDE 410 +PDE Sbjct: 405 TKPDE 409 Score = 24.3 bits (51), Expect(2) = 0.003 Identities = 15/57 (26%), Positives = 24/57 (42%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 D+F P RF + LL F G R C G + + + ++L F ++L Sbjct: 408 DEFIPERFVDNPIEYKGQHFELLPFGAGRRVCPGMATGITIVELGLLSLLYFFDWSL 464
>CP392_DROME (P82713) Probable cytochrome P450 309a2 (EC 1.14.-.-) (CYPCCCIXA2)| Length = 538 Score = 40.8 bits (94), Expect = 0.003 Identities = 21/53 (39%), Positives = 26/53 (49%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 + F P RF NG + L FS GPR C+G AML KS + +L F Sbjct: 452 EAFKPERFDNGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNF 504
>CP4FE_MOUSE (Q9EP75) Cytochrome P450 4F14 (EC 1.14.13.30) (Leukotriene-B4| omega-hydroxylase) (Leukotriene-B4 20-monooxygenase) (Cytochrome P450-LTB-omega) (Cyp4f-14) Length = 524 Score = 40.8 bits (94), Expect = 0.003 Identities = 22/51 (43%), Positives = 29/51 (56%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 ++P RF + + P A + FS GPR CIGQ FAM E K +A L +F Sbjct: 440 YDPFRFDPENIKDSS-PLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRF 489 Score = 32.0 bits (71), Expect = 1.4 Identities = 20/72 (27%), Positives = 36/72 (50%), Gaps = 5/72 (6%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGE---- 437 +TM + E+LRL+ P + R T D+++ TIPK +I +H + VW + Sbjct: 381 LTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVY 440 Query: 436 DAGSVQPDEVRE 401 D P+ +++ Sbjct: 441 DPFRFDPENIKD 452
>CP27A_HUMAN (Q02318) Cytochrome P450 27, mitochondrial precursor (EC| 1.14.13.15) (Cytochrome P-450C27/25) (Sterol 26-hydroxylase) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase) Length = 531 Score = 36.6 bits (83), Expect(2) = 0.004 Identities = 19/62 (30%), Positives = 32/62 (51%), Gaps = 3/62 (4%) Frame = -1 Query: 429 DQFNPMRFANGVARAA---KVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 + F P R+ A + P + F G RAC+G+ A LE + ++A ++QK+ L Sbjct: 442 ESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVL 501 Query: 258 SP 253 +P Sbjct: 502 AP 503 Score = 23.1 bits (48), Expect(2) = 0.004 Identities = 19/59 (32%), Positives = 23/59 (38%) Frame = -3 Query: 592 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQP 416 VL ETLRLY R ++ V PK V + RD + E S QP Sbjct: 389 VLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPE-SFQP 446
>CP1A2_MACFU (Q4H4C3) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2)| Length = 515 Score = 34.3 bits (77), Expect(2) = 0.004 Identities = 18/60 (30%), Positives = 29/60 (48%), Gaps = 2/60 (3%) Frame = -1 Query: 426 QFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 +F P RF A G + ++ F +G R CIG+ E +A +LQ+ F++ P Sbjct: 425 EFRPERFLTAEGTTINKPLSEKIMLFGLGKRRCIGEVLGKWEVFLFLAILLQQLEFSVPP 484 Score = 25.4 bits (54), Expect(2) = 0.004 Identities = 10/34 (29%), Positives = 18/34 (52%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 TT D + IP+E + I ++ D ++WG+ Sbjct: 389 TTRDTTLNGFYIPRECCVFINQWQVNHDPQLWGD 422
>CP1A2_MACFA (O77809) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2)| Length = 515 Score = 34.3 bits (77), Expect(2) = 0.004 Identities = 18/60 (30%), Positives = 29/60 (48%), Gaps = 2/60 (3%) Frame = -1 Query: 426 QFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 +F P RF A G + ++ F +G R CIG+ E +A +LQ+ F++ P Sbjct: 425 EFRPERFLTAEGTTINKPLSEKIMLFGLGKRRCIGEVLGKWEVFLFLAILLQQLEFSVPP 484 Score = 25.4 bits (54), Expect(2) = 0.004 Identities = 10/34 (29%), Positives = 18/34 (52%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 TT D + IP+E + I ++ D ++WG+ Sbjct: 389 TTRDTTLNGFYIPRECCVFINQWQVNHDPQLWGD 422
>C76A2_SOLME (P37122) Cytochrome P450 76A2 (EC 1.14.-.-) (CYPLXXVIA2) (P-450EG7)| Length = 505 Score = 34.3 bits (77), Expect(2) = 0.004 Identities = 21/64 (32%), Positives = 35/64 (54%), Gaps = 1/64 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFM-QRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGS 425 M VL E+LRL+ P F+ R+T D +PK+ +++ A + RD + W +D S Sbjct: 360 MQAVLKESLRLHPPLPFLIPRETIQDTKFMGYDVPKDTQVLVNAWAIGRDPECW-DDPMS 418 Query: 424 VQPD 413 +P+ Sbjct: 419 FKPE 422 Score = 25.4 bits (54), Expect(2) = 0.004 Identities = 19/85 (22%), Positives = 34/85 (40%), Gaps = 5/85 (5%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL----S 256 F P RF + L+ F G R C+G + ++L++F + L S Sbjct: 419 FKPERFLGSKIDVKGQHYGLIPFGAGRRMCVGLPLGHRMMHFALGSLLREFEWELPDGVS 478 Query: 255 PSYVHAPADF-LTLQPKFGLPVVMK 184 P ++ +T + + L V+ K Sbjct: 479 PKSINMDGSMGVTARKRDSLKVIPK 503
>CP2DE_BOVIN (Q01361) Cytochrome P450 2D14 (EC 1.14.14.1) (CYPIID14) (Fragment)| Length = 487 Score = 38.1 bits (87), Expect(2) = 0.004 Identities = 20/56 (35%), Positives = 31/56 (55%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F+P F + R K A + FS G RAC+G+ A +E ++LQ FSF++ Sbjct: 404 RFHPEHFLDAQGRFVK-QEAFIPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 458 Score = 21.6 bits (44), Expect(2) = 0.004 Identities = 10/38 (26%), Positives = 18/38 (47%) Frame = -3 Query: 556 LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 L + T+ D+ V IPK ++ + +D+ VW Sbjct: 362 LGLPHMTSRDIEVQGFHIPKGTTLITNLSSVLKDETVW 399
>CP2DH_MACFA (Q29488) Cytochrome P450 2D17 (EC 1.14.14.1) (CYPIID17)| Length = 497 Score = 40.4 bits (93), Expect = 0.004 Identities = 21/56 (37%), Positives = 31/56 (55%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F+P F + K P A L FS G RAC+G+ A +E +LQ+FSF++ Sbjct: 414 RFHPEHFLDAQGHFVK-PEAFLPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSV 468
>CP2A8_MESAU (P24454) Cytochrome P450 2A8 (EC 1.14.14.1) (CYPIIA8) (P450-MC1)| (P450-AFB) Length = 494 Score = 40.4 bits (93), Expect = 0.004 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 9/84 (10%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 250 + FNP F++ + K +A + FS+G R C G++ A +E T++Q F F SP Sbjct: 409 NDFNPQHFSDDKGQFKK-SNAFMPFSVGKRYCFGESLAKMELFIFFTTIMQNFCFK-SP- 465 Query: 249 YVHAPAD---------FLTLQPKF 205 AP D F + PKF Sbjct: 466 --QAPQDIDVTPQYFSFAAIPPKF 487
>CP2J1_RABIT (P52786) Cytochrome P450 2J1 (EC 1.14.14.1) (CYPIIJ1) (P-450IB)| Length = 500 Score = 40.4 bits (93), Expect = 0.004 Identities = 24/58 (41%), Positives = 31/58 (53%), Gaps = 1/58 (1%) Frame = -1 Query: 435 TRDQFNPMRFA-NGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 T D FNP F NG K A + FSIG RAC+G+ A E +++QKF+F Sbjct: 415 TPDTFNPEHFLENG---QFKKKEAFIPFSIGKRACLGEQLAKSELFIFFTSLMQKFTF 469
>STCS_EMENI (Q00714) Probable sterigmatocystin biosynthesis P450 monooxygenase| stcS (EC 1.14.-.-) (Cytochrome P450 59) Length = 505 Score = 40.4 bits (93), Expect = 0.004 Identities = 19/38 (50%), Positives = 25/38 (65%) Frame = -1 Query: 360 AFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 AF GPR+CIGQ AMLE + +A L++F A P+Y Sbjct: 426 AFEFGPRSCIGQTLAMLELRVALAMTLREFDIA--PAY 461
>CP52P_CANTR (P30612) Cytochrome P450 52C1 (EC 1.14.14.-) (CYPLIIC1)| (Alkane-inducible P450-ALK7) Length = 505 Score = 40.4 bits (93), Expect = 0.004 Identities = 21/53 (39%), Positives = 29/53 (54%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 D+F P R++ + R +P FS GPRAC+GQ +EA V +LQ F Sbjct: 427 DKFAPERWSESLRRTEFIP-----FSAGPRACLGQQLPRVEASYVTIRLLQTF 474
>C71A2_SOLME (P37118) Cytochrome P450 71A2 (EC 1.14.-.-) (CYPLXXIA2) (P-450EG4)| Length = 505 Score = 40.4 bits (93), Expect = 0.004 Identities = 20/57 (35%), Positives = 30/57 (52%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +++ P RF N A + LL F G R C G +FA+ + +A ++ KF FAL Sbjct: 417 EEYQPERFLNSDADVKGLNFKLLPFGAGRRGCPGSSFAIAVIELALARLVHKFDFAL 473
>CP17A_PAPHU (Q9GLD2) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 40.4 bits (93), Expect = 0.004 Identities = 23/54 (42%), Positives = 29/54 (53%), Gaps = 1/54 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 DQF P RF N P + L F GPR+CIG+ A E +MA +LQ+F Sbjct: 410 DQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>CP17A_PAPCY (Q8HYN0) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 40.4 bits (93), Expect = 0.004 Identities = 23/54 (42%), Positives = 29/54 (53%), Gaps = 1/54 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 DQF P RF N P + L F GPR+CIG+ A E +MA +LQ+F Sbjct: 410 DQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>CP17A_MACMU (Q8HYM9) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 40.4 bits (93), Expect = 0.004 Identities = 23/54 (42%), Positives = 29/54 (53%), Gaps = 1/54 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 DQF P RF N P + L F GPR+CIG+ A E +MA +LQ+F Sbjct: 410 DQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>CP17A_MACFA (Q2XVA1) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 40.4 bits (93), Expect = 0.004 Identities = 23/54 (42%), Positives = 29/54 (53%), Gaps = 1/54 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 DQF P RF N P + L F GPR+CIG+ A E +MA +LQ+F Sbjct: 410 DQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
>C86A2_ARATH (O23066) Cytochrome P450 86A2 (EC 1.14.-.-)| Length = 553 Score = 40.4 bits (93), Expect = 0.004 Identities = 21/60 (35%), Positives = 34/60 (56%) Frame = -1 Query: 372 HALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAPADFLTLQPKFGLPV 193 + +AF+ GPR C+G++ A L+ K++ A VL + ++P + LTL K GL V Sbjct: 447 YRFVAFNAGPRICLGKDLAYLQMKTIAAAVLLRHRLTVAPGHKVEQKMSLTLFMKNGLLV 506
>CP4F3_HUMAN (Q08477) Cytochrome P450 4F3 (EC 1.14.13.30) (CYPIVF3)| (Leukotriene-B(4) omega-hydroxylase) (Leukotriene-B(4) 20-monooxygenase) (Cytochrome P450-LTB-omega) Length = 520 Score = 40.4 bits (93), Expect = 0.004 Identities = 22/51 (43%), Positives = 29/51 (56%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 ++P RF + + P A + FS GPR CIGQ FAM E K V+ L +F Sbjct: 440 YDPFRFDPKNIKE-RSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRF 489 Score = 31.2 bits (69), Expect = 2.4 Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 5/73 (6%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGE---- 437 +TM + E+LRL+ P + R T D+V+ IPK +I H + VW + Sbjct: 381 LTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVY 440 Query: 436 DAGSVQPDEVRER 398 D P ++ER Sbjct: 441 DPFRFDPKNIKER 453
>CP3A6_RABIT (P11707) Cytochrome P450 3A6 (EC 1.14.14.1) (CYPIIIA6) (P450-3C)| Length = 501 Score = 40.4 bits (93), Expect = 0.004 Identities = 20/57 (35%), Positives = 29/57 (50%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 D+F P RF+ P+ F GPR C+G FA++ K + ++Q FSF L Sbjct: 410 DEFRPERFSKKNKDNIN-PYIYHPFGAGPRNCLGMRFALMNIKLALVRLMQNFSFKL 465 Score = 39.3 bits (90), Expect = 0.009 Identities = 26/80 (32%), Positives = 41/80 (51%), Gaps = 1/80 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSV 422 + MV++ETLRLY A ++R D+ + IPK +++ +HRD + W E Sbjct: 354 LDMVVNETLRLYPIAGRLERVCKKDVDINGTFIPKGTIVMMPTYALHRDPQHWTE----- 408 Query: 421 QPDEVR-ERGRESGQGSARP 365 PDE R ER + + + P Sbjct: 409 -PDEFRPERFSKKNKDNINP 427
>CP4P3_DROME (Q9V559) Probable cytochrome P450 4p3 (EC 1.14.-.-) (CYPIVP3)| Length = 515 Score = 40.4 bits (93), Expect = 0.004 Identities = 21/53 (39%), Positives = 32/53 (60%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 ++F P RF ++ +A + FS G R CIGQ FAM E K++M +L++F Sbjct: 431 EEFRPERFLPENSQNRHT-YAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQF 482
>CP1A2_RABIT (P00187) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450 isozyme| 4) (P450-PM4) (P450 LM4) Length = 515 Score = 40.4 bits (93), Expect = 0.004 Identities = 26/79 (32%), Positives = 39/79 (49%), Gaps = 2/79 (2%) Frame = -1 Query: 429 DQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 256 ++F P RF A+G A + + F +G R CIG+ A E +A +LQ+ F++ Sbjct: 424 EEFRPERFLTADGAAINKPLSEKVTLFGLGKRRCIGETLARWEVFLFLAILLQRLEFSVP 483 Query: 255 PSYVHAPADFLTLQPKFGL 199 P P D L P +GL Sbjct: 484 PG---VPVD---LTPIYGL 496
>CP67_UROFA (O00061) Cytochrome P450 67 (EC 1.14.-.-) (CYPLXVII)| (Planta-induced rust protein 16) (Fragment) Length = 541 Score = 40.4 bits (93), Expect = 0.004 Identities = 16/41 (39%), Positives = 25/41 (60%) Frame = -1 Query: 369 ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 A F IGP AC+ +N A +E + V+AT+L F + +P + Sbjct: 468 AFFGFLIGPGACVAKNLAWMEMRLVVATILTNFDLSFAPGF 508
>CP1A1_CANFA (P56590) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (DAH1)| Length = 524 Score = 33.5 bits (75), Expect(2) = 0.005 Identities = 19/58 (32%), Positives = 31/58 (53%), Gaps = 2/58 (3%) Frame = -1 Query: 426 QFNPMRFA--NGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F P RF +G A + ++ F +G R CIG+ A LE +A +LQ+ F++ Sbjct: 430 EFQPERFLTLDGTINKA-LSEKVILFGLGKRKCIGETIARLEVFLFLAILLQQVEFSV 486 Score = 25.8 bits (55), Expect(2) = 0.005 Identities = 12/42 (28%), Positives = 21/42 (50%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 TT D + IPK + + ++ D+K+WG + QP+ Sbjct: 394 TTRDTSLSGFYIPKGRCVFVNQWQINHDQKLWG-NPSEFQPE 434
>CP2D6_PANPA (Q2XNC9) Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6)| Length = 497 Score = 40.0 bits (92), Expect = 0.005 Identities = 21/56 (37%), Positives = 31/56 (55%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 259 +F+P F + K P A L FS G RAC+G+ A +E ++LQ FSF++ Sbjct: 414 RFHPEHFLDAQGHFVK-PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 468
>CP2DG_CAVPO (Q64403) Cytochrome P450 2D16 (EC 1.14.14.1) (CYPIID16)| Length = 500 Score = 40.0 bits (92), Expect = 0.005 Identities = 23/65 (35%), Positives = 35/65 (53%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 244 F+P F + R K A + FS GPR C+G+ A +E ++LQ+FSF++ P Sbjct: 418 FHPGHFLDAEGRFVK-REAFMPFSAGPRICLGEPLARMELFLFFTSLLQRFSFSV-PEGQ 475 Query: 243 HAPAD 229 P+D Sbjct: 476 PRPSD 480
>CP2J2_HUMAN (P51589) Cytochrome P450 2J2 (EC 1.14.14.1) (CYPIIJ2) (Arachidonic| acid epoxygenase) Length = 502 Score = 40.0 bits (92), Expect = 0.005 Identities = 24/58 (41%), Positives = 31/58 (53%), Gaps = 1/58 (1%) Frame = -1 Query: 435 TRDQFNPMRFA-NGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 T D FNP F NG K A + FSIG RAC+G+ A E +++QKF+F Sbjct: 417 TPDTFNPDHFLENG---QFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTF 471 Score = 31.2 bits (69), Expect = 2.4 Identities = 27/95 (28%), Positives = 40/95 (42%), Gaps = 4/95 (4%) Frame = -3 Query: 592 VLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQP 416 V+HE R+ L + R+ T D + +PK I+ +HRD W + P Sbjct: 365 VIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA-TPDTFNP 423 Query: 415 DEVRERGRESGQGSARPARILDRA---EGVHRPEL 320 D E G+ + + P I RA E + R EL Sbjct: 424 DHFLENGQFKKREAFMPFSIGKRACLGEQLARTEL 458
>CP120_SYNY3 (Q59990) Putative cytochrome P450 120 (EC 1.14.-.-)| Length = 444 Score = 40.0 bits (92), Expect = 0.005 Identities = 20/59 (33%), Positives = 31/59 (52%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 ++F+P RF + P A + F G R C+G+ FA LE K ++Q+F + L P Sbjct: 360 EKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDWTLLP 418
>CP2A2_RAT (P15149) Cytochrome P450 2A2 (EC 1.14.14.1) (CYPIIA2) (Testosterone| 15-alpha-hydroxylase) (P450-UT-4) Length = 492 Score = 40.0 bits (92), Expect = 0.005 Identities = 21/53 (39%), Positives = 29/53 (54%) Frame = -1 Query: 423 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 265 FNP F + + K A L FSIG R C+G + A +E ++ T+LQ F F Sbjct: 409 FNPQHFLDDKGQLKKNA-AFLPFSIGKRFCLGDSLAKMELFLLLTTILQNFRF 460
>CP1A1_SHEEP (P56591) Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-C)| (P4501A1) Length = 519 Score = 33.9 bits (76), Expect(2) = 0.006 Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 1/59 (1%) Frame = -1 Query: 426 QFNPMRFANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 +F P RF KV ++ F +G R CIG+ A LE +A +L + F ++P Sbjct: 433 EFRPERFLTTDGTVNKVLSEKVIIFGLGKRQCIGEIIARLEVFLFLAILLHQVEFHVTP 491 Score = 25.0 bits (53), Expect(2) = 0.006 Identities = 12/42 (28%), Positives = 21/42 (50%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPD 413 TT D + IPK + + ++ D+K+W ED +P+ Sbjct: 397 TTRDTNLNGFYIPKGXCVFVNQWQINHDQKLW-EDPSEFRPE 437
>CP1A2_BALAC (Q3LFT9) Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2)| Length = 515 Score = 33.1 bits (74), Expect(2) = 0.006 Identities = 21/78 (26%), Positives = 37/78 (47%), Gaps = 2/78 (2%) Frame = -1 Query: 426 QFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 +F P RF ++ + + ++ F +G R CIG+ A E +A +LQ+ F++ P Sbjct: 425 EFRPERFLTSHDTTISKTLSEKVMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 484 Query: 252 SYVHAPADFLTLQPKFGL 199 + L P +GL Sbjct: 485 GVK------VDLTPTYGL 496 Score = 25.8 bits (55), Expect(2) = 0.006 Identities = 11/34 (32%), Positives = 17/34 (50%) Frame = -3 Query: 538 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 437 T D + IPKE + I ++ D K+WG+ Sbjct: 389 TIRDTTLNGFYIPKELCVFINQWQVNHDPKLWGD 422
>CP2DF_CANFA (Q29473) Cytochrome P450 2D15 (EC 1.14.14.1) (CYPIID15) (P450 DUT2)| Length = 499 Score = 34.3 bits (77), Expect(2) = 0.006 Identities = 21/66 (31%), Positives = 33/66 (50%) Frame = -1 Query: 426 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 247 +F P F + K A + FS G R C+G+ A +E +LQ+FSF++ P+ Sbjct: 416 RFYPEHFLDAQGHFVK-HEAFMPFSAGRRVCLGEPLARMELFLFFTCLLQRFSFSV-PAG 473 Query: 246 VHAPAD 229 P+D Sbjct: 474 QPRPSD 479 Score = 24.6 bits (52), Expect(2) = 0.006 Identities = 16/52 (30%), Positives = 25/52 (48%), Gaps = 2/52 (3%) Frame = -3 Query: 592 VLHETLRLYGPA--LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 V+HE R +G L + T+ D V IPK ++ + +D+KVW Sbjct: 361 VIHEVQR-FGDIVPLGVPHMTSRDTEVQGFLIPKGTTLITNLSSVLKDEKVW 411
>CP21A_HUMAN (P08686) Cytochrome P450 21 (EC 1.14.99.10) (Cytochrome P450 XXI)| (Steroid 21-hydroxylase) (21-OHase) (P450-C21) (P-450c21) (P450-C21B) Length = 494 Score = 33.1 bits (74), Expect(2) = 0.006 Identities = 23/61 (37%), Positives = 32/61 (52%) Frame = -1 Query: 363 LAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAPADFLTLQPKFGLPVVMK 184 LAF G R C+G+ A LE V+ +LQ +F L PS P +LQP V++K Sbjct: 419 LAFGCGARVCLGEPLARLELFVVLTRLLQ--AFTLLPSGDALP----SLQPLPHCSVILK 472 Query: 183 L 181 + Sbjct: 473 M 473 Score = 25.8 bits (55), Expect(2) = 0.006 Identities = 20/73 (27%), Positives = 29/73 (39%), Gaps = 1/73 (1%) Frame = -3 Query: 601 MTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGS 425 + + E LRL L + +TT + IP+ I+ H D+ VW E Sbjct: 345 LNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVW-ERPHE 403 Query: 424 VQPDEVRERGRES 386 PD E G+ S Sbjct: 404 FWPDRFLEPGKNS 416
>CP2CU_RABIT (Q29510) Cytochrome P450 2C30 (EC 1.14.14.1) (CYPIIC30)| Length = 489 Score = 39.7 bits (91), Expect = 0.007 Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 5/82 (6%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF--ALS 256 ++F+P F + K + L FSIG RAC G+ A +E V+ T+LQ F+ + Sbjct: 404 EKFDPGHFLDASGNFKKSDY-FLPFSIGKRACAGEGLARMELFLVLTTILQHFTLKPLVD 462 Query: 255 PSYVH-APAD--FLTLQPKFGL 199 P + P D FL++ P + L Sbjct: 463 PKDIDPTPVDNGFLSVPPSYEL 484
>CP51A_BOVIN (Q4PJW3) Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI)| (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM) Length = 502 Score = 39.7 bits (91), Expect = 0.007 Identities = 21/62 (33%), Positives = 34/62 (54%) Frame = -1 Query: 432 RDQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 253 R FNP R+ + A+ A + F G CIG+NFA ++ K++ +T+L+ + F L Sbjct: 417 RLDFNPDRYLED-SPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLID 475 Query: 252 SY 247 Y Sbjct: 476 GY 477 Score = 37.0 bits (84), Expect = 0.044 Identities = 23/70 (32%), Positives = 29/70 (41%) Frame = -3 Query: 589 LHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAGSVQPDE 410 + ETLRL P + M R T + V TIP H + + R K W E PD Sbjct: 366 IKETLRLRPPIMTMMRLAKTPLTVAGYTIPPGHQVCVSPTVNQRLKDSWVERL-DFNPDR 424 Query: 409 VRERGRESGQ 380 E SG+ Sbjct: 425 YLEDSPASGE 434
>CP17A_CAVPO (Q64410) Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17)| (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase) Length = 508 Score = 39.7 bits (91), Expect = 0.007 Identities = 22/54 (40%), Positives = 29/54 (53%), Gaps = 1/54 (1%) Frame = -1 Query: 429 DQFNPMRFANGVARAAKVPHA-LLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 271 DQF P RF + VP + L F GPR+C+G+ A E + A +LQKF Sbjct: 410 DQFMPERFLDPTGSQIIVPSSSYLPFGAGPRSCVGEALARQEIFLITAWLLQKF 463
>CP2B4_RABIT (P00178) Cytochrome P450 2B4 (EC 1.14.14.1) (CYPIIB4) (P450-LM2)| (Isozyme 2) (P450 types B0 and B1) Length = 491 Score = 39.7 bits (91), Expect = 0.007 Identities = 29/78 (37%), Positives = 38/78 (48%), Gaps = 2/78 (2%) Frame = -1 Query: 435 TRDQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 262 T + FNP F ANG A K + FS+G R C+G+ A E T+LQ FS A Sbjct: 404 TPNTFNPGHFLDANG---ALKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIA 460 Query: 261 LSPSYVHAPADFLTLQPK 208 SP P + + L P+ Sbjct: 461 -SP----VPPEDIDLTPR 473
>CP2B1_RAT (P00176) Cytochrome P450 2B1 (EC 1.14.14.1) (CYPIIB1) (P450-B)| (P450b) (P450-PB1 and P450-PB2) (P450-LM2) Length = 491 Score = 39.7 bits (91), Expect = 0.007 Identities = 31/76 (40%), Positives = 39/76 (51%), Gaps = 2/76 (2%) Frame = -1 Query: 429 DQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 256 D FNP F ANG A K A + FS G R C+G+ A E T+LQ FS + Sbjct: 406 DSFNPEHFLDANG---ALKKSEAFMPFSTGKRICLGEGIARNELFLFFTTILQNFSVS-- 460 Query: 255 PSYVHAPADFLTLQPK 208 S++ AP D + L PK Sbjct: 461 -SHL-APKD-IDLTPK 473
>CP11A_ONCMY (Q07217) Cytochrome P450 11A1, mitochondrial precursor (EC| 1.14.15.6) (CYPXIA1) (P450(SCC)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase) Length = 514 Score = 30.0 bits (66), Expect(2) = 0.008 Identities = 18/49 (36%), Positives = 27/49 (55%) Frame = -3 Query: 589 LHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 443 L ETLRL+ A+ +QR T ++V+ IP + +G M RD V+ Sbjct: 379 LKETLRLHPVAVSLQRYITEEIVIQNYHIPCGTLVQLGLYAMGRDPDVF 427 Score = 28.5 bits (62), Expect(2) = 0.008 Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 1/68 (1%) Frame = -1 Query: 363 LAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY-VHAPADFLTLQPKFGLPVVM 187 L F GPR C+G+ A E + + +L+ F VH+ + + L K P+++ Sbjct: 449 LGFGFGPRQCLGRRIAETEMQLFLIHMLENFRVDKQRQVEVHSTFELILLPEK---PILL 505 Query: 186 KLLDV*NG 163 L + +G Sbjct: 506 TLKPLKSG 513 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 95,299,850 Number of Sequences: 219361 Number of extensions: 2242265 Number of successful extensions: 8365 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 7704 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 8341 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5367617986 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
