Clone Information

BLAST Search Result

Clone Name	rbasd13g19
Clone Library Name	barley_pub

No.	Definition	Score (bits)	E Value
1	HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3	97	5e-20
2	HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing...	94	4e-19
3	HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing...	94	4e-19
4	HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing...	93	6e-19
5	HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing...	91	4e-18
6	NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7...	85	2e-16
7	RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 k...	82	2e-15
8	RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (R...	81	3e-15
9	RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Reg...	80	4e-15
10	RCC2_BRARE (Q6NYE2) Protein RCC2 homolog	79	9e-15
11	RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (R...	79	9e-15
12	RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (R...	79	9e-15
13	RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator	79	1e-14
14	NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7...	77	3e-14
15	RCC2_MOUSE (Q8BK67) Protein RCC2	77	3e-14
16	GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related ...	76	7e-14
17	RCC2_XENLA (Q52KW8) Protein RCC2 homolog	76	9e-14
18	RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulat...	74	4e-13
19	ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein...	72	2e-12
20	ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)	71	2e-12
21	RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (R...	71	2e-12
22	RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromo...	71	3e-12
23	RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator	71	3e-12
24	RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromo...	70	4e-12
25	RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (R...	70	4e-12
26	NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7...	70	5e-12
27	RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromo...	70	5e-12
28	RCC1_XENLA (P25183) Regulator of chromosome condensation	70	5e-12
29	NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7...	67	4e-11
30	RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regula...	67	4e-11
31	ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein...	67	4e-11
32	GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related ...	66	1e-10
33	NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7...	64	3e-10
34	RCC1_DROME (P25171) Regulator of chromosome condensation (Chroma...	64	4e-10
35	NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7...	64	4e-10
36	RCC1_CANAL (P52499) Protein RCC1	63	6e-10
37	MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (E...	62	1e-09
38	RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)	61	3e-09
39	MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (E...	58	2e-08
40	HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-...	58	3e-08
41	WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region ...	57	5e-08
42	RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-) ...	56	8e-08
43	WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region ...	55	1e-07
44	RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 ...	51	3e-06
45	ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)	46	8e-05
46	RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell c...	40	0.006
47	FBX24_HUMAN (O75426) F-box only protein 24	39	0.010
48	FBX24_MOUSE (Q9D417) F-box only protein 24	38	0.029
49	YB9W_YEAST (P38352) F-box protein YBR280C	35	0.14
50	UNC5B_HUMAN (Q8IZJ1) Netrin receptor UNC5B precursor (Unc-5 homo...	34	0.41
51	TKT_SCHPO (Q9URM2) Probable transketolase (EC 2.2.1.1) (TK)	32	1.2
52	PHLD_MOUSE (O70362) Phosphatidylinositol-glycan-specific phospho...	30	7.8

>HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3|
          Length = 1050

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 59/163 (36%), Positives = 82/163 (50%), Gaps = 2/163 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQP-RSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           WG N +GQLG+G   P ++ P RV  L  + L  +AAGG HS AL+  G V+ WG    G
Sbjct: 161 WGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAG 220

Query: 451 RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
           +LG  D+K     P  V+LL  + +V +SCG  H+ VLT  G +F++             
Sbjct: 221 QLGLSDEKDRES-PCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQL----- 274

Query: 271 VTTGHP-MEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
              GH  M   +N   P+      G  +   +ACG +HTLA V
Sbjct: 275 ---GHDSMNDEVN---PRRVLELMGS-EVTQIACGRQHTLAFV 310



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 45/162 (27%), Positives = 75/162 (46%), Gaps = 1/162 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPR-SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           +WG    GQLG+  T+   + P  ++ L+  +++ ++ G WH  AL  +G+ + WG+  H
Sbjct: 107 SWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSH 166

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G+LG G +  S   P +V+ L G  + QV+ GG HS  L+  G +F +            
Sbjct: 167 GQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSD 226

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
           +     P  V + L   K            Y++CG  HT  +
Sbjct: 227 EKDRESPCHVKL-LRTQKVV----------YISCGEEHTAVL 257



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 51/159 (32%), Positives = 80/159 (50%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRL 446
           G N  GQLG    +  ++P ++  L++  ++ +A G  HS AL+  G++++WG G  G+L
Sbjct: 59  GLNTKGQLG--HEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQL 116

Query: 445 GFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVT 266
           G    + S  VP  +Q L  + I+QVSCG  H + L +DG+ F++               
Sbjct: 117 GLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHG--------Q 168

Query: 265 TGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
            G   E P    P +   S EG+  A  VA GG H+ A+
Sbjct: 169 LGLGKEFPSQASPQRV-RSLEGIPLAQ-VAAGGAHSFAL 205



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 47/149 (31%), Positives = 74/149 (49%), Gaps = 1/149 (0%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG N  GQLG+ D + R  P  V+ L    +V I+ G  H+A LTK G V+ +G G  G+
Sbjct: 214 WGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQ 273

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVV-LTSDGRIFSYXXXXXXXXXXXRK 272
           LG  D  +  + P +V  L G ++ Q++CG  H++  + S G I+++            +
Sbjct: 274 LGH-DSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAF------GCGARGQ 326

Query: 271 VTTGHPMEVPINLPPPKTSTSSEGLWQAN 185
           + TGH   V       K  +  +G W A+
Sbjct: 327 LGTGHTCNV-------KCPSPVKGYWAAH 348



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 48/162 (29%), Positives = 76/162 (46%), Gaps = 2/162 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPR--SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           WG    GQ GI        ++P     +S+ S+ ++A GG HS  L ++GEVY  G    
Sbjct: 4   WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G+LG   + +    P Q+  LA + I+ V+CG +HS+ L+  G++FS+            
Sbjct: 64  GQLGHEREGNK---PEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGL-- 118

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
            +TT   + VP  +      T  +       V+CG  H LA+
Sbjct: 119 -MTTEDSVAVPRLIQKLNQQTILQ-------VSCGNWHCLAL 152

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>HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4834

 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 53/160 (33%), Positives = 82/160 (51%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG+ +YG+LG G +     P++++ L+ L +V +  G   S ALTK G VY WG+G++ 
Sbjct: 4168 SWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYH 4227

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
            RLG G D      P QVQ L G+ ++ ++ G  H V  T DG ++++             
Sbjct: 4228 RLGHGSDDHVRR-PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDG-- 4284

Query: 271  VTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLA 152
             TT         +  P+   + +G  + N VACG  HTLA
Sbjct: 4285 -TTN-------AIQRPRLVAALQGK-KVNRVACGSAHTLA 4315



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 56/171 (32%), Positives = 86/171 (50%), Gaps = 6/171 (3%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG  + G+LG        +P  +E L    + DIA G  HSAALT  GE+Y WG GE+G
Sbjct: 3070 SWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG 3129

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGRIFSYXXXXXXXXXXX 278
            RLG GD+ ++ + P  V++L G  ++QV+CG     ++ LT +G +FS+           
Sbjct: 3130 RLGHGDN-TTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFG----- 3183

Query: 277  RKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI----VTWT 137
                 G       N+P      + +G+ Q   + CG + +LA+    V WT
Sbjct: 3184 ---KLGRGGSEGCNIPQNIERLNGQGVCQ---IECGAQFSLALTKSGVVWT 3228



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 42/109 (38%), Positives = 66/109 (60%), Gaps = 2/109 (1%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG  E G+LG G+  P  +P  +E L  + +VD+AAGG HSA +T  G++Y WG+G +G
Sbjct: 4062 SWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYG 4121

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGRIFSY 311
            RLG  D +   + P  V+ L G  +V ++CG     ++ LT D  ++S+
Sbjct: 4122 RLGHSDSE-DQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSW 4169



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 43/130 (33%), Positives = 71/130 (54%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG+ +YG+LG G +     P  +E L +L +V +  G   S ALTK+G+VY+WG+G++ 
Sbjct: 628  SWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQ 687

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
            RLG G ++     P  ++ L G+ ++ V+ G TH + LT D  + S+            +
Sbjct: 688  RLGHGTEEHVR-YPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLR 746

Query: 271  VTTGHPMEVP 242
            VT   P  +P
Sbjct: 747  VTKPEPAALP 756



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 39/108 (36%), Positives = 65/108 (60%), Gaps = 2/108 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW--HSAALTKEGEVYAWGRGEH 455
           WG   YG+LG G ++  + P+ V GL  L ++D+A G     + A+T+ G+V++WG G++
Sbjct: 575 WGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDY 634

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           G+LG G        P  ++ L   D+V+V CG   S+ LT DG+++S+
Sbjct: 635 GKLGRGGSDGC-KTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSW 681



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 42/113 (37%), Positives = 66/113 (58%), Gaps = 6/113 (5%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLS----LVDIAAGGWHSAALTKEGEVYAWGR 464
           +WG  + G+LG GDT P  +P  +   S       +V IA G  +SAA+T EGE+Y WGR
Sbjct: 518 SWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGR 577

Query: 463 GEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGRIFSY 311
           G +GRLG G  +    +P+ V  L G  ++ V+CG     ++ +T +G+++S+
Sbjct: 578 GNYGRLGHGSSE-DEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSW 629



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 39/108 (36%), Positives = 61/108 (56%), Gaps = 2/108 (1%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW--HSAALTKEGEVYAWGRGEH 455
            WG   YG+LG  D++ + +P  VE L    +VDIA G     +  LT +  V++WG G++
Sbjct: 4115 WGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDY 4174

Query: 454  GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            G+LG G       VP+++  L G  +V+V CG   SV LT  G ++++
Sbjct: 4175 GKLGRGGSDGC-KVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTW 4221



 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 48/165 (29%), Positives = 77/165 (46%), Gaps = 2/165 (1%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG+ ++G+LG G ++  + P  +E L+   +  I  G   S ALTK G V+ WG+G++ 
Sbjct: 3176 SWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYF 3235

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
            RLG G D      P  V+ L G+ IV V+ G  H + +T  G+++++             
Sbjct: 3236 RLGHGSDVHVRK-PQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTT 3294

Query: 271  VTTGHPMEVPINLPPPKTSTSSEGL--WQANYVACGGRHTLAIVT 143
                 P             T  +GL   +   VACG  H++A  T
Sbjct: 3295 TVNRKP-------------TLVQGLEGQKITRVACGSSHSVAWTT 3326



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 49/164 (29%), Positives = 73/164 (44%), Gaps = 2/164 (1%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
            WG N+  QLG         P   E LS L++V +A G     A+T EG+VYA G   +GR
Sbjct: 2964 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGR 3023

Query: 448  LGFGDDKSSHMVPLQVQLLAGEDI--VQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
            LG G    +  +P Q+  L+   +  V V  GG H+  LT DG++FS+            
Sbjct: 3024 LGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFS 3083

Query: 274  KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVT 143
            ++    P  +       KT    +       +ACG  H+ A+ +
Sbjct: 3084 RMNCDKPRLI----EALKTKRIRD-------IACGSSHSAALTS 3116



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 37/97 (38%), Positives = 58/97 (59%), Gaps = 10/97 (10%)
 Frame = -3

Query: 571 PIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 398
           P  V+GL++ ++V IAA   G H  AL   GEVY+WG G+ GRLG GD      VPL+  
Sbjct: 484 PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGD-----TVPLEEP 538

Query: 397 LL--------AGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            +        AG+ +V ++CG T+S  +T++G ++++
Sbjct: 539 KVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTW 575



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 43/160 (26%), Positives = 68/160 (42%), Gaps = 54/160 (33%)
 Frame = -3

Query: 628  WGNNEYGQ---------------------------------------------------- 605
            WG+N  GQ                                                    
Sbjct: 3957 WGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGR 4016

Query: 604  LGIGDTQPRSQPIRVEGLSNLSLVDIA--AGGWHSAALTKEGEVYAWGRGEHGRLGFGDD 431
            LGIG T+  S P  +E + ++ +  +A  +GG H  AL+ EGEVY+WG  E G+LG G +
Sbjct: 4017 LGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHG-N 4075

Query: 430  KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            +S    P  ++ L G ++V V+ GG HS  +T+ G ++++
Sbjct: 4076 RSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTW 4115

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>HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4836

 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 53/160 (33%), Positives = 82/160 (51%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG+ +YG+LG G +     P++++ L+ L +V +  G   S ALTK G VY WG+G++ 
Sbjct: 4170 SWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYH 4229

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
            RLG G D      P QVQ L G+ ++ ++ G  H V  T DG ++++             
Sbjct: 4230 RLGHGSDDHVRR-PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDG-- 4286

Query: 271  VTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLA 152
             TT         +  P+   + +G  + N VACG  HTLA
Sbjct: 4287 -TTN-------AIQRPRLVAALQGK-KVNRVACGSAHTLA 4317



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 41/109 (37%), Positives = 66/109 (60%), Gaps = 2/109 (1%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG  E G+LG G+  P  +P  +E L  + +VD+AAGG HSA +T  G++Y WG+G +G
Sbjct: 4064 SWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYG 4123

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGRIFSY 311
            RLG  D +   + P  V+ L G  ++ ++CG     ++ LT D  ++S+
Sbjct: 4124 RLGHSDSE-DQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSW 4171



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 54/171 (31%), Positives = 85/171 (49%), Gaps = 6/171 (3%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG  + G+LG        +P  ++ L    + DIA G  HSA LT  GE+Y WG GE+G
Sbjct: 3071 SWGEGDDGKLGHFSRMNCDKPRLIQALKTKRIRDIAYGSSHSAPLTSSGELYTWGLGEYG 3130

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGRIFSYXXXXXXXXXXX 278
            RLG GD+ ++ + P  V++L G  ++QV+CG     ++ LT +G +FS+           
Sbjct: 3131 RLGHGDN-TTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFG----- 3184

Query: 277  RKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI----VTWT 137
                 G       N+P      + +G+ Q   + CG + +LA+    V WT
Sbjct: 3185 ---KLGRGGSEGCNIPQNIERLNGQGVCQ---IECGAQFSLALTKSGVVWT 3229



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 43/130 (33%), Positives = 70/130 (53%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG+ +YG+LG G +     P  +E L +L ++ +  G   S ALTK+G+VY+WG+G++ 
Sbjct: 629  SWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQ 688

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
            RLG G ++     P  ++ L G+ ++ V+ G TH +VLT D  + S+             
Sbjct: 689  RLGHGTEEHVR-YPKLLEGLQGKKVIDVAAGSTHCLVLTEDSEVHSWGSNDQCQHFDTLG 747

Query: 271  VTTGHPMEVP 242
            VT   P   P
Sbjct: 748  VTKPEPTAFP 757



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 38/108 (35%), Positives = 65/108 (60%), Gaps = 2/108 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW--HSAALTKEGEVYAWGRGEH 455
           WG   YG+LG G ++  + P+ V GL  L ++D+A G     + A+T+ G+V++WG G++
Sbjct: 576 WGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDY 635

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           G+LG G        P  ++ L   D+++V CG   S+ LT DG+++S+
Sbjct: 636 GKLGRGGSDGC-KTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSW 682



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 42/113 (37%), Positives = 66/113 (58%), Gaps = 6/113 (5%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLS----LVDIAAGGWHSAALTKEGEVYAWGR 464
           +WG  + G+LG GDT P  +P  +   S       +V IA G  +SAA+T EGE+Y WGR
Sbjct: 519 SWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGR 578

Query: 463 GEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGRIFSY 311
           G +GRLG G  +    +P+ V  L G  ++ V+CG     ++ +T +G+++S+
Sbjct: 579 GNYGRLGHGSSE-DEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSW 630



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 38/108 (35%), Positives = 61/108 (56%), Gaps = 2/108 (1%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW--HSAALTKEGEVYAWGRGEH 455
            WG   YG+LG  D++ + +P  VE L    ++DIA G     +  LT +  V++WG G++
Sbjct: 4117 WGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDY 4176

Query: 454  GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            G+LG G       VP+++  L G  +V+V CG   SV LT  G ++++
Sbjct: 4177 GKLGRGGSDGC-KVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTW 4223



 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 48/165 (29%), Positives = 77/165 (46%), Gaps = 2/165 (1%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG+ ++G+LG G ++  + P  +E L+   +  I  G   S ALTK G V+ WG+G++ 
Sbjct: 3177 SWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYF 3236

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
            RLG G D      P  V+ L G+ IV V+ G  H + +T  G+++++             
Sbjct: 3237 RLGHGSDVHVRK-PQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTT 3295

Query: 271  VTTGHPMEVPINLPPPKTSTSSEGL--WQANYVACGGRHTLAIVT 143
                 P             T  +GL   +   VACG  H++A  T
Sbjct: 3296 TVNRKP-------------TLVQGLEGQKITRVACGSSHSVAWTT 3327



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 40/108 (37%), Positives = 57/108 (52%), Gaps = 2/108 (1%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
            WG N+  QLG         P   E LS L++V +A G     A+T EG+VY+ G   +GR
Sbjct: 2965 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYSCGEATNGR 3024

Query: 448  LGFGDDKSSHMVPLQVQLLAGEDI--VQVSCGGTHSVVLTSDGRIFSY 311
            LG G    +  +P Q+  L+   +  V V  GG H+  LT DG++FS+
Sbjct: 3025 LGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSW 3072



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 37/97 (38%), Positives = 58/97 (59%), Gaps = 10/97 (10%)
 Frame = -3

Query: 571 PIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 398
           P  V+GL++ ++V IAA   G H  AL   GEVY+WG G+ GRLG GD      VPL+  
Sbjct: 485 PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGD-----TVPLEEP 539

Query: 397 LL--------AGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            +        AG+ +V ++CG T+S  +T++G ++++
Sbjct: 540 KVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTW 576



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 43/160 (26%), Positives = 68/160 (42%), Gaps = 54/160 (33%)
 Frame = -3

Query: 628  WGNNEYGQ---------------------------------------------------- 605
            WG+N  GQ                                                    
Sbjct: 3959 WGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGR 4018

Query: 604  LGIGDTQPRSQPIRVEGLSNLSLVDIA--AGGWHSAALTKEGEVYAWGRGEHGRLGFGDD 431
            LGIG T+  S P  +E + ++ +  +A  +GG H  AL+ EGEVY+WG  E G+LG G +
Sbjct: 4019 LGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHG-N 4077

Query: 430  KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            +S    P  ++ L G ++V V+ GG HS  +T+ G ++++
Sbjct: 4078 RSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTW 4117



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 34/108 (31%), Positives = 57/108 (52%), Gaps = 3/108 (2%)
 Frame = -3

Query: 625  GNNEYGQLGIG---DTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
            G    G+LG+G    T P  + I       +  V + +GG H+ ALT +G+V++WG G+ 
Sbjct: 3018 GEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDD 3077

Query: 454  GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            G+LG     +    P  +Q L  + I  ++ G +HS  LTS G ++++
Sbjct: 3078 GKLGHFSRMNCDK-PRLIQALKTKRIRDIAYGSSHSAPLTSSGELYTW 3124

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>HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4912

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 47/109 (43%), Positives = 68/109 (62%), Gaps = 2/109 (1%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG  E G+LG G+     +P  VE L    + D+A G  HSAA++ +GE+Y WG GE+G
Sbjct: 3096 SWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYG 3155

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGRIFSY 311
            RLG GD+ ++ + P  V  LAG  +VQV+CG     ++ LT DG +FS+
Sbjct: 3156 RLGHGDN-TTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSW 3203



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 42/109 (38%), Positives = 63/109 (57%), Gaps = 2/109 (1%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            AWG  E G+LG G+     +P  VE L+ +S+ DIA G  HSAA+T  G V  WG+G +G
Sbjct: 4159 AWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYG 4218

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGRIFSY 311
            RLG GD +   + P  V+ L G   + ++CG     ++ +T D  ++S+
Sbjct: 4219 RLGHGDSE-DQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSW 4266



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 48/163 (29%), Positives = 76/163 (46%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG+ +YG+LG G +     P ++E L+ L +V +  G   S ALTK G VY WG+G+  
Sbjct: 4265 SWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFH 4324

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
            RLG G        P +V  L G+ I+ ++ G  H V  +  G ++++            +
Sbjct: 4325 RLGHGSVDHVRR-PKKVAALQGKKIISIATGSLHCVACSDSGEVYTW--------GDNDE 4375

Query: 271  VTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVT 143
               G      I  P    +   + + +   V CG  HTLA+ T
Sbjct: 4376 GQLGDGTVTAIQRPRLVAALQGKHIVK---VTCGSAHTLALST 4415



 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 36/107 (33%), Positives = 63/107 (58%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            +WG+ ++G+LG G ++    P  +E LS + +V I  G   S ALT+ GEV+ WG+G++ 
Sbjct: 3202 SWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYY 3261

Query: 451  RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            RLG G D+     P  +  L G  ++ V+ G  H + +T  G+++++
Sbjct: 3262 RLGHGGDQHVRK-PQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAW 3307



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 39/108 (36%), Positives = 62/108 (57%), Gaps = 2/108 (1%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL--TKEGEVYAWGRGEH 455
            WG   YG+LG GD++ + +P  VE L     +DIA G   +  L  T +  V++WG G++
Sbjct: 4212 WGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDY 4271

Query: 454  GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            G+LG G      + P +++ LAG  +V+V CG   SV LT  G ++++
Sbjct: 4272 GKLGRGGSDGCKL-PYKIESLAGLGVVKVECGSQFSVALTKSGAVYTW 4318



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 2/162 (1%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW--HSAALTKEGEVYAWGRGEH 455
            WG  EYG+LG GD   + +P  V  L+   +V +A G     + ALT++G V++WG G+ 
Sbjct: 3149 WGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDF 3208

Query: 454  GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
            G+LG G  + S   P +++ L+G  +VQ+ CG   S+ LT  G ++++            
Sbjct: 3209 GKLGRGGSEGSD-TPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDY------- 3260

Query: 274  KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
                GH  +  +  P P          +  +VA G  H LA+
Sbjct: 3261 -YRLGHGGDQHVRKPQPIGGLRGR---RVIHVAVGALHCLAV 3298



 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 40/109 (36%), Positives = 63/109 (57%), Gaps = 2/109 (1%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA--AGGWHSAALTKEGEVYAWGRGE 458
            A G    G+LG+G +   + P  +  L ++ +  +A  +GG H  ALT EGEVYAWG GE
Sbjct: 4105 ATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGE 4164

Query: 457  HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
             G+LG G ++ S+  P  V+ L G  +  ++CG  HS  +T+ G + ++
Sbjct: 4165 DGKLGHG-NRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTW 4212



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 43/108 (39%), Positives = 66/108 (61%), Gaps = 2/108 (1%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW--HSAALTKEGEVYAWGRGEH 455
            WG   Y +LG G++  RS P  V  LS+  +VD+A G    HS ALT EG V+AWG G++
Sbjct: 692  WGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDY 751

Query: 454  GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            G+LG G+   S + P+ V+ L    + +V  G   SV L+S+G+++++
Sbjct: 752  GKLGNGNCNGS-LQPILVESL--PRVQRVFAGSQFSVALSSEGQLYTW 796



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 41/111 (36%), Positives = 62/111 (55%), Gaps = 4/111 (3%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +WG  E  +LG GDT  R+ P ++  L    +  +  G  +SAA+T  G +  WGRG + 
Sbjct: 639 SWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYA 698

Query: 451 RLGFG--DDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGRIFSY 311
           RLG G  DD+S   +P  V  L+   +V V+ G    HS+ LTS+G +F++
Sbjct: 699 RLGHGNSDDRS---LPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAW 746



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 37/109 (33%), Positives = 64/109 (58%), Gaps = 2/109 (1%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA--AGGWHSAALTKEGEVYAWGRGE 458
            A G    G+LG+G T     P ++  L    +  +A  +GG H+ ALT +G+V++WG GE
Sbjct: 3042 ACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGE 3101

Query: 457  HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
             G+LG G ++++   P  V+ L  + I  V+CG +HS  ++S G ++++
Sbjct: 3102 DGKLGHG-NRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTW 3149



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 35/98 (35%), Positives = 53/98 (54%), Gaps = 3/98 (3%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
            WG  +Y +LG G  Q   +P  + GL    ++ +A G  H  A+T  G+VYAWG  +HG+
Sbjct: 3255 WGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQ 3314

Query: 448  LGFGDDKSSHMVPLQVQLLAGEDIV---QVSCGGTHSV 344
             G G+      V  +  L+ G D V   +V+CG +HS+
Sbjct: 3315 QGSGNT----FVNKKPALVIGLDAVFVNRVACGSSHSI 3348



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 50/164 (30%), Positives = 70/164 (42%), Gaps = 4/164 (2%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
            WG N+  QLG         P   + +S L  + IA G      ++++G+VYA G G +GR
Sbjct: 2991 WGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGR 3050

Query: 448  LGFGDDKSSHMVPLQVQLLAGEDI----VQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXX 281
            LG G    +H VPL  QL          V V  GG H++ LT DG++FS+          
Sbjct: 3051 LGLG---VTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGH 3107

Query: 280  XRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
              + T   P  V            +    +   VACG  H+ AI
Sbjct: 3108 GNRTTLDKPRLV-----------EALRAKKIRDVACGSSHSAAI 3140



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 50/162 (30%), Positives = 76/162 (46%), Gaps = 2/162 (1%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
            WG+N  GQLG  +      P   E LS L  V +A G     A+T +G+++A G G  GR
Sbjct: 4054 WGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGR 4113

Query: 448  LGFGDDKSSHMVPLQVQLLAGEDI--VQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
            LG G    S  +P  +  L    +  V V+ GG H + LT++G ++++            
Sbjct: 4114 LGVG-GSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAW------GEGEDG 4166

Query: 274  KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
            K+  G+ M    +   PK      G+  A+ +ACG  H+ AI
Sbjct: 4167 KLGHGNRM----SYDRPKLVEHLNGMSVAD-IACGSAHSAAI 4203



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 38/108 (35%), Positives = 53/108 (49%), Gaps = 1/108 (0%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE-H 455
            AWG+ +YG+LG G+     QPI VE L  +  V   AG   S AL+ EG++Y WG+    
Sbjct: 745  AWGDGDYGKLGNGNCNGSLQPILVESLPRVQRV--FAGSQFSVALSSEGQLYTWGKATCL 802

Query: 454  GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            G            VP  V  L  + IV V+    H + L+S G +F +
Sbjct: 803  GHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGW 850



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 2/94 (2%)
 Frame = -3

Query: 586 QPRSQPIRVEGLSNLSLVDIAAG--GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 413
           +P ++P+ +E +++   + IA    G H  A+      Y+WG GE  RLG G D  +  V
Sbjct: 600 KPEAEPLPMEEVAHDVFISIAGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHG-DTHARAV 658

Query: 412 PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           P ++  L    +  V CG ++S  +T  G + ++
Sbjct: 659 PTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTW 692



 Score = 37.7 bits (86), Expect = 0.029
 Identities = 18/44 (40%), Positives = 26/44 (59%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAA 500
            AWG+N++GQ G G+T    +P  V GL  + +  +A G  HS A
Sbjct: 3306 AWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIA 3349



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 19/50 (38%), Positives = 25/50 (50%)
 Frame = -3

Query: 607 QLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 458
           QL     Q  S P  V  L +  +VD+A    H  AL+  GEV+ WGR +
Sbjct: 805 QLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRND 854

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>HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing protein 5|
           (Cyclin-E-binding protein 1)
          Length = 1024

 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 43/108 (39%), Positives = 68/108 (62%), Gaps = 1/108 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +WG NE GQLG+G T+ +  P  +EGL N  +  +A GG HSA LT++G ++ +G G+HG
Sbjct: 214 SWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHG 273

Query: 451 RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSD-GRIFSY 311
           +LG  +   + + P  V  L G  + Q++CG  H++   SD G++FS+
Sbjct: 274 QLGH-NSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSF 320



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 55/164 (33%), Positives = 82/164 (50%), Gaps = 1/164 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQ-PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           AWG N +GQLG+G   P +  P  VE L+ + L  I+AG  HS AL+  G +Y+WG+ E 
Sbjct: 161 AWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNEC 220

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G+LG G  +S    P  ++ L  + +  V+CGG+HS +LT DG +F++            
Sbjct: 221 GQLGLGHTESKD-DPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNS 279

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVT 143
                 P  V   +            ++   +ACG  HTLA V+
Sbjct: 280 TQNELRPCLVAELVG-----------YRVTQIACGRWHTLAYVS 312



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 2/134 (1%)
 Frame = -3

Query: 553 LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV 374
           L    ++ I  G +HS AL+K GE++AWG+  HG+LG G    S   P  V+ LAG  + 
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194

Query: 373 QVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGL- 197
           Q+S G  HS+ L+  G I+S+              +   P  +             EGL 
Sbjct: 195 QISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLI-------------EGLD 241

Query: 196 -WQANYVACGGRHT 158
             +  +VACGG H+
Sbjct: 242 NQKVEFVACGGSHS 255



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 17/79 (21%), Positives = 35/79 (44%)
 Frame = -3

Query: 547 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQV 368
           N+ +  +  G  H   L+ +G+ + +       L F              +L  + I+Q+
Sbjct: 96  NMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFES------------ILQEKKIIQI 143

Query: 367 SCGGTHSVVLTSDGRIFSY 311
           +CG  HS+ L+  G +F++
Sbjct: 144 TCGDYHSLALSKGGELFAW 162

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>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8)
          Length = 698

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 44/105 (41%), Positives = 63/105 (60%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           +G+   G LG G+    SQP  VE L    +V +A G  H  AL+ +GE++AWGRG+ GR
Sbjct: 421 FGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGR 480

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
           LG G  + SH  P QV +  G++  +V CG   S++LTS GR+ +
Sbjct: 481 LGLG-TRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSPGRVLA 524



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 33/89 (37%), Positives = 51/89 (57%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           +G+N++GQLG    +    P RV+GL  + +V +A G   + A+  EGEVY+WG+G  GR
Sbjct: 591 FGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWGKGTRGR 650

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSC 362
           LG  D+ +    P+Q+       +  VSC
Sbjct: 651 LGRRDEDAGLPRPVQLDETHPYMVTSVSC 679



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 34/116 (29%), Positives = 61/116 (52%)
 Frame = -3

Query: 586 QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPL 407
           QP+     +EG S +++  +A G   +A LT  G +  +G G +G LG G+  +    P 
Sbjct: 383 QPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGN-LTDISQPT 441

Query: 406 QVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPI 239
            V+ L G ++VQV+CG +H + L++DG +F++            + +   P +VP+
Sbjct: 442 IVEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPV 497



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 46/180 (25%), Positives = 76/180 (42%), Gaps = 14/180 (7%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEG--------------LSNLSLVDIAAGGWHSAALT 494
            A G+N + +LG+       +P+  +               L    L+ +  G  HSAA+T
Sbjct: 524  ACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLGTAHSAAIT 583

Query: 493  KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
              G+ Y +G  +HG+LG    + S   P +VQ L G  +V V+CG   +V + ++G ++S
Sbjct: 584  ASGDCYTFGSNQHGQLGTSSRRVSR-APCRVQGLEGIKMVMVACGDAFTVAVGAEGEVYS 642

Query: 313  YXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVTWTD 134
            +            +   G P  V ++   P   TS           C G   LA+ + TD
Sbjct: 643  WGKGTRGRLGRRDE-DAGLPRPVQLDETHPYMVTSVS--------CCHGNTLLAVRSVTD 693



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 39/174 (22%), Positives = 63/174 (36%), Gaps = 13/174 (7%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           AWG  + G+LG+G  +  + P +V          +  G   S  LT  G V A G     
Sbjct: 472 AWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSPGRVLACGSNRFN 531

Query: 451 RLGFGD-------------DKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           +LG                +++    PL    L  E ++ V  G  HS  +T+ G  +++
Sbjct: 532 KLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTF 591

Query: 310 XXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
                       +  +  P  V             EG+ +   VACG   T+A+
Sbjct: 592 GSNQHGQLGTSSRRVSRAPCRV----------QGLEGI-KMVMVACGDAFTVAV 634



 Score = 37.7 bits (86), Expect = 0.029
 Identities = 44/159 (27%), Positives = 63/159 (39%), Gaps = 14/159 (8%)
 Frame = -3

Query: 577 SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 398
           S P+R+  L N  +V +AAG    A +T+ G +  W   E   LG G      ++P  V+
Sbjct: 328 SSPLRLPML-NTEVVQVAAGRTQKAGVTRSGRLILW---EAPPLGAG---GGTLLPGAVE 380

Query: 397 L------------LAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHP 254
           L             +G  I  V+CG   +  LT  G I ++                GH 
Sbjct: 381 LPQPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNG--------CLGHG 432

Query: 253 MEVPINLPPPKTSTSSEGL--WQANYVACGGRHTLAIVT 143
               I+ P     T  E L  ++   VACG  H LA+ T
Sbjct: 433 NLTDISQP-----TIVEALLGYEMVQVACGASHVLALST 466

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>RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like|
           protein TD-60)
          Length = 522

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 40/107 (37%), Positives = 65/107 (60%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +WG NE GQLG GDT+    P  +EGLS+  +V  A G  H+ ALT+ G V+A+G  + G
Sbjct: 173 SWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMG 232

Query: 451 RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           +LG G+   +   P Q+ +  G+ I +++CG   S+++   G ++S+
Sbjct: 233 QLGLGNQTDAVPSPAQI-MYNGQPITKMACGAEFSMIMDCKGNLYSF 278



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 27/67 (40%), Positives = 42/67 (62%)
 Frame = -3

Query: 511 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 332
           HS  +T EG++++WGR E G+LG GD K     P  ++ L+ E IV  +CG  H++ LT 
Sbjct: 161 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVE-APRLIEGLSHEVIVSAACGRNHTLALTE 219

Query: 331 DGRIFSY 311
            G +F++
Sbjct: 220 TGSVFAF 226



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 26/131 (19%)
 Frame = -3

Query: 631 AWGNNEYGQLGIG----------------DTQPRSQPIRVEG--------LSNLSLVDIA 524
           ++G  EYGQLG                  +  PR   I +E         + N+ + D+A
Sbjct: 277 SFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVA 336

Query: 523 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL--LAGEDIVQVSCGGTH 350
            G  H+  L  +  V++WG G +GRLG  + K   MVP  V+L    G    Q+  G T 
Sbjct: 337 CGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK-DEMVPRLVKLFDFPGRGASQIYAGYTC 395

Query: 349 SVVLTSDGRIF 317
           S  ++  G +F
Sbjct: 396 SFAVSEVGGLF 406

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>RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 46/132 (34%), Positives = 68/132 (51%), Gaps = 1/132 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           AWG N  GQ+G G T  +  P RV G L N  +++IA G   S A+   GEVY WG   +
Sbjct: 175 AWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWGYNGN 234

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G+LG G    +   P +V  L G  + +V+CG  H++VLT +G+I+++            
Sbjct: 235 GQLGLGSS-GNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGN 293

Query: 274 KVTTGHPMEVPI 239
           K    +P  V +
Sbjct: 294 KSNQSYPTPVVV 305



 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 49/162 (30%), Positives = 80/162 (49%), Gaps = 2/162 (1%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGR 449
           G N  G LG+GD Q   +P R++ L+   +  ++ G G H    T +GEV+ WG   + +
Sbjct: 71  GTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQ 130

Query: 448 LGFGDDKSSHMVPLQVQL-LAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
           LG G      +VP  +   L+ + +++V+CG  HS+VLTSDG +F++            +
Sbjct: 131 LGNGTTNHG-LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAW------GYNNSGQ 183

Query: 271 VTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
           V +G     PI    P+  T          +ACG   ++A+V
Sbjct: 184 VGSGSTANQPI----PRRVTGCLQNKVVMNIACGQMCSMAVV 221



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 1/161 (0%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVE-GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           WG+N Y QLG G T     P  +   LSN  ++++A G +HS  LT +GEV+AWG    G
Sbjct: 123 WGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSG 182

Query: 451 RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
           ++G G   +  +       L  + ++ ++CG   S+ +   G ++ +             
Sbjct: 183 QVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSS 242

Query: 271 VTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
                      N P P    + +G+ +   VACG  HTL +
Sbjct: 243 G----------NQPTPCRVAALQGI-RVQRVACGYAHTLVL 272



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 37/107 (34%), Positives = 55/107 (51%), Gaps = 1/107 (0%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG N  GQLG+G +  +  P RV  L  + +  +A G  H+  LT EG++YAWG   +G+
Sbjct: 229 WGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQ 288

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH-SVVLTSDGRIFSY 311
           LG G +KS+   P  V +     I   +C   H S   T  G ++ +
Sbjct: 289 LGTG-NKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMW 334



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 25/58 (43%), Positives = 33/58 (56%), Gaps = 2/58 (3%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGR 464
           AWG N YGQLG G+   +S P  V  +    +++IAA      SAA T+ G VY WG+
Sbjct: 280 AWGANSYGQLGTGNKSNQSYPTPVV-VEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQ 336

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>RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 46/132 (34%), Positives = 67/132 (50%), Gaps = 1/132 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           AWG N  GQ+G G T  +  P RV G L N  ++ IA G   S A+   GEVY WG   +
Sbjct: 175 AWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIACGQMCSMAVVDTGEVYVWGYNGN 234

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G+LG G    +   P +V  L G  + +V+CG  H++VLT +G+I+++            
Sbjct: 235 GQLGLGSS-GNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGN 293

Query: 274 KVTTGHPMEVPI 239
           K    +P  V +
Sbjct: 294 KSNQSYPTPVVV 305



 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 49/162 (30%), Positives = 80/162 (49%), Gaps = 2/162 (1%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGR 449
           G N  G LG+GD Q   +P R++ L+   +  ++ G G H    T +GEV+ WG   + +
Sbjct: 71  GTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQ 130

Query: 448 LGFGDDKSSHMVPLQVQL-LAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
           LG G      +VP  +   L+ + +++V+CG  HS+VLTSDG +F++            +
Sbjct: 131 LGNGTTNHG-LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAW------GYNNSGQ 183

Query: 271 VTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
           V +G     PI    P+  T          +ACG   ++A+V
Sbjct: 184 VGSGSTANQPI----PRRVTGCLQNKVVMSIACGQMCSMAVV 221



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 1/161 (0%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVE-GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           WG+N Y QLG G T     P  +   LSN  ++++A G +HS  LT +GEV+AWG    G
Sbjct: 123 WGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSG 182

Query: 451 RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
           ++G G   +  +       L  + ++ ++CG   S+ +   G ++ +             
Sbjct: 183 QVGSGSTANQPIPRRVTGCLQNKVVMSIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSS 242

Query: 271 VTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
                      N P P    + +G+ +   VACG  HTL +
Sbjct: 243 G----------NQPTPCRVAALQGI-RVQRVACGYAHTLVL 272



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 36/101 (35%), Positives = 52/101 (51%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG N  GQLG+G +  +  P RV  L  + +  +A G  H+  LT EG++YAWG   +G+
Sbjct: 229 WGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQ 288

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDG 326
           LG G +KS+   P  V +     I   +C   H+    S G
Sbjct: 289 LGTG-NKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKSQG 328



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 24/58 (41%), Positives = 33/58 (56%), Gaps = 2/58 (3%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGR 464
           AWG N YGQLG G+   +S P  V  +    +++IAA      SAA ++ G VY WG+
Sbjct: 280 AWGANSYGQLGTGNKSNQSYPTPVV-VEKDRIIEIAACHSAHTSAAKSQGGHVYMWGQ 336

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>RCC2_BRARE (Q6NYE2) Protein RCC2 homolog|
          Length = 495

 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 40/107 (37%), Positives = 63/107 (58%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +WG N+ GQLG GDT+    P  +EGL    +V  A G  H+ ALT+ G VY +G  + G
Sbjct: 146 SWGRNDKGQLGHGDTKRLEAPKLIEGLGEEVIVAAACGRNHTLALTENGTVYTFGENKLG 205

Query: 451 RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           +LG G+   + + P  +Q   G+ IV+V+CG   S+++   G ++S+
Sbjct: 206 QLGQGNQTDAVLSPATIQ-YNGQPIVKVACGAEFSMIVDCKGNLYSF 251



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 30/89 (33%), Positives = 52/89 (58%), Gaps = 2/89 (2%)
 Frame = -3

Query: 571 PIRVEGLSNLSLVDIAAG--GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 398
           P R   LS++ +  + +G    HS  +T EG++++WGR + G+LG GD K     P  ++
Sbjct: 112 PHRYGCLSDVQVSCVVSGPCAAHSLIITTEGKLWSWGRNDKGQLGHGDTKRLE-APKLIE 170

Query: 397 LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            L  E IV  +CG  H++ LT +G ++++
Sbjct: 171 GLGEEVIVAAACGRNHTLALTENGTVYTF 199



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 41/131 (31%), Positives = 57/131 (43%), Gaps = 26/131 (19%)
 Frame = -3

Query: 631 AWGNNEYGQLG-------IGDTQ---------PRSQPIRVEG--------LSNLSLVDIA 524
           ++G  EYGQLG       I   Q         PR   I +E         + N+   D+A
Sbjct: 250 SFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVAIFIEKTKDGQVLPVPNVVARDVA 309

Query: 523 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL--LAGEDIVQVSCGGTH 350
            G  H+  L  +  V++WG G +GRLG  + K   MVP  V+L    G    Q+ CG   
Sbjct: 310 CGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK-DEMVPRLVKLFDFPGRGATQIYCGYQC 368

Query: 349 SVVLTSDGRIF 317
           S  L+  G +F
Sbjct: 369 SFALSEMGGLF 379

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>RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2)
          Length = 551

 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 45/132 (34%), Positives = 67/132 (50%), Gaps = 1/132 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           AWG N  GQ+G G T  +  P RV G L N  +V IA G     A+   GEVY WG   +
Sbjct: 175 AWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGN 234

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G+LG G+   +   P +V  L G  + +V+CG  H++VLT +G+++++            
Sbjct: 235 GQLGLGNS-GNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN 293

Query: 274 KVTTGHPMEVPI 239
           K    +P  V +
Sbjct: 294 KSNQSYPTPVTV 305



 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 50/162 (30%), Positives = 80/162 (49%), Gaps = 2/162 (1%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGR 449
           G N  G LG+GD Q   +P R++ L+   +  ++ G G H    T EGEV+ WG   + +
Sbjct: 71  GTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQ 130

Query: 448 LGFGDDKSSHMVPLQVQL-LAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
           LG G      +VP  +   L+ + +++V+CG  HS+VLTSDG +F++            +
Sbjct: 131 LGNGTTNHG-LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAW------GYNNSGQ 183

Query: 271 VTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
           V +G      +N P P+  T          +ACG    +A+V
Sbjct: 184 VGSGS----TVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVV 221



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 44/161 (27%), Positives = 71/161 (44%), Gaps = 1/161 (0%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVE-GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           WG+N Y QLG G T     P  +   LSN  ++++A G +HS  LT +GEV+AWG    G
Sbjct: 123 WGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSG 182

Query: 451 RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
           ++G G   +  +       L  + +V ++CG    + +   G ++ +             
Sbjct: 183 QVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNS 242

Query: 271 VTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
                      N P P    + +G+ +   VACG  HTL +
Sbjct: 243 G----------NQPTPCRVAALQGI-RVQRVACGYAHTLVL 272



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 39/107 (36%), Positives = 57/107 (53%), Gaps = 1/107 (0%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG N  GQLG+G++  +  P RV  L  + +  +A G  H+  LT EG+VYAWG   +G+
Sbjct: 229 WGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQ 288

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH-SVVLTSDGRIFSY 311
           LG G +KS+   P  V +     I   +C  TH S   T  G ++ +
Sbjct: 289 LGTG-NKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMW 334



 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 25/58 (43%), Positives = 33/58 (56%), Gaps = 2/58 (3%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGR 464
           AWG N YGQLG G+   +S P  V  +    +++IAA      SAA T+ G VY WG+
Sbjct: 280 AWGANSYGQLGTGNKSNQSYPTPVT-VEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336

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>RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like) (CHC1-L)
           (RCC1-like G exchanging factor)
          Length = 551

 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 45/132 (34%), Positives = 67/132 (50%), Gaps = 1/132 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           AWG N  GQ+G G T  +  P RV G L N  +V IA G     A+   GEVY WG   +
Sbjct: 175 AWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGN 234

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G+LG G+   +   P +V  L G  + +V+CG  H++VLT +G+++++            
Sbjct: 235 GQLGLGNS-GNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGN 293

Query: 274 KVTTGHPMEVPI 239
           K    +P  V +
Sbjct: 294 KSNQSYPTPVTV 305



 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 50/162 (30%), Positives = 80/162 (49%), Gaps = 2/162 (1%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGR 449
           G N  G LG+GD Q   +P R++ L+   +  ++ G G H    T EGEV+ WG   + +
Sbjct: 71  GTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQ 130

Query: 448 LGFGDDKSSHMVPLQVQL-LAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
           LG G      +VP  +   L+ + +++V+CG  HS+VLTSDG +F++            +
Sbjct: 131 LGNGTTNHG-LVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAW------GYNNSGQ 183

Query: 271 VTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
           V +G      +N P P+  T          +ACG    +A+V
Sbjct: 184 VGSGS----TVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVV 221



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 44/161 (27%), Positives = 71/161 (44%), Gaps = 1/161 (0%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVE-GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           WG+N Y QLG G T     P  +   LSN  ++++A G +HS  LT +GEV+AWG    G
Sbjct: 123 WGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSG 182

Query: 451 RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRK 272
           ++G G   +  +       L  + +V ++CG    + +   G ++ +             
Sbjct: 183 QVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNS 242

Query: 271 VTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
                      N P P    + +G+ +   VACG  HTL +
Sbjct: 243 G----------NQPTPCRVAALQGI-RVQRVACGYAHTLVL 272



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 39/107 (36%), Positives = 57/107 (53%), Gaps = 1/107 (0%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG N  GQLG+G++  +  P RV  L  + +  +A G  H+  LT EG+VYAWG   +G+
Sbjct: 229 WGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQ 288

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH-SVVLTSDGRIFSY 311
           LG G +KS+   P  V +     I   +C  TH S   T  G ++ +
Sbjct: 289 LGTG-NKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMW 334



 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 25/58 (43%), Positives = 33/58 (56%), Gaps = 2/58 (3%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGR 464
           AWG N YGQLG G+   +S P  V  +    +++IAA      SAA T+ G VY WG+
Sbjct: 280 AWGANSYGQLGTGNKSNQSYPTPVT-VEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336

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>RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1003

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 53/162 (32%), Positives = 85/162 (52%), Gaps = 1/162 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGL-SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           A GNNE GQLG+GDT+ RS    +    S   +  ++AG   SAALT++GE++ WG    
Sbjct: 111 AGGNNE-GQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTEDGELFMWGDNSE 169

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G++G  ++ ++  VP QV +  G+ I  +SCG  HS  +T++G+++++            
Sbjct: 170 GQIGL-ENVTNVCVPQQVTV--GKPISWISCGYYHSAFVTTEGQLYTFGEPECGKLGLPN 226

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
           ++   H M  P+   P K             VACGG HT+ +
Sbjct: 227 QLLVNHRMPQPVPGIPGKVV----------QVACGGGHTVVL 258



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 43/162 (26%), Positives = 67/162 (41%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           +G+N +GQLG+G     S+P  V+ L    +   A G  H+   T+ G+VYA G    G+
Sbjct: 59  FGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRNHTLVSTEGGKVYAAGGNNEGQ 118

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKV 269
           LG GD +      L     +   I Q+S G   S  LT DG +F +              
Sbjct: 119 LGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLENVT 178

Query: 268 TTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVT 143
               P +V +  P              ++++CG  H+  + T
Sbjct: 179 NVCVPQQVTVGKP-------------ISWISCGYYHSAFVTT 207



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 38/99 (38%), Positives = 59/99 (59%), Gaps = 1/99 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG+N  GQ+G+ +      P +V     +S   I+ G +HSA +T EG++Y +G  E G+
Sbjct: 164 WGDNSEGQIGLENVTNVCVPQQVTVGKPISW--ISCGYYHSAFVTTEGQLYTFGEPECGK 221

Query: 448 LGFGDD-KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 335
           LG  +    +H +P  V  + G+ +VQV+CGG H+VVLT
Sbjct: 222 LGLPNQLLVNHRMPQPVPGIPGK-VVQVACGGGHTVVLT 259



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 32/101 (31%), Positives = 54/101 (53%), Gaps = 2/101 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +G  ++GQLG+G      S P  +E + +  +  IA G  H+A +T  G +Y +G G HG
Sbjct: 266 FGLGQFGQLGLGTFLFETSVPKAIEHIKDQKISFIACGENHTALITDMGLMYTFGDGRHG 325

Query: 451 RLGFG-DDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 332
           +LG G ++ ++  +P          +  VSCGG H++V  +
Sbjct: 326 KLGLGLENSTNQFIPTLCSNFLRFIVQLVSCGGCHTLVFAT 366



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 42/164 (25%), Positives = 74/164 (45%), Gaps = 2/164 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQ--PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           +G  E G+LG+ +        P  V G+    +V +A GG H+  LT++  VY +G G+ 
Sbjct: 214 FGEPECGKLGLPNQLLVNHRMPQPVPGIPG-KVVQVACGGGHTVVLTEKA-VYTFGLGQF 271

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G+LG G       VP  ++ +  + I  ++CG  H+ ++T  G ++++            
Sbjct: 272 GQLGLGTFLFETSVPKAIEHIKDQKISFIACGENHTALITDMGLMYTFGDGRHGKLGLGL 331

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVT 143
           + +T   +          T  S+   +    V+CGG HTL   T
Sbjct: 332 ENSTNQFI---------PTLCSNFLRFIVQLVSCGGCHTLVFAT 366



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 22/72 (30%), Positives = 40/72 (55%)
 Frame = -3

Query: 529 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH 350
           ++ G  H+A +T   ++Y +G    G+LG G  KS+   P  V+ L  E +   +CG  H
Sbjct: 40  LSCGDEHTAVVTGNNKLYMFGSNNWGQLGLG-SKSTVSKPTCVKALKPEKVKFAACGRNH 98

Query: 349 SVVLTSDGRIFS 314
           ++V T  G++++
Sbjct: 99  TLVSTEGGKVYA 110

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>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8) (NIMA-related kinase 12a)
          Length = 692

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 42/102 (41%), Positives = 58/102 (56%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           +G+   G LG G     SQP  VE L    +V +A G  H  AL+ E E++AWGRG+ GR
Sbjct: 415 FGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGR 474

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 323
           LG G  + SH  P QV +  G++  +V CG   S++LT  G+
Sbjct: 475 LGLG-TRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQ 515



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 30/89 (33%), Positives = 49/89 (55%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           +G+N++GQLG    +    P +V+GL  + +  +A G   + A+  E EVY+WG+G  GR
Sbjct: 585 FGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGR 644

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSC 362
           LG  D+ +    P+Q+       +  VSC
Sbjct: 645 LGRRDEDAGLPRPVQLDETHPYTVTSVSC 673



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 40/141 (28%), Positives = 70/141 (49%), Gaps = 2/141 (1%)
 Frame = -3

Query: 586 QPRSQPIR--VEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 413
           QP+ Q I   +EG S +++  +A G + +A LT  G +  +G G +G LG G   +    
Sbjct: 375 QPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGS-LTDISQ 433

Query: 412 PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINL 233
           P  V+ L G ++VQV+CG +H + L+++  +F++            + +   P +VP  +
Sbjct: 434 PTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVP--M 491

Query: 232 PPPKTSTSSEGLWQANYVACG 170
           PP +         +A  V CG
Sbjct: 492 PPGQ---------EAQRVVCG 503



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 48/180 (26%), Positives = 77/180 (42%), Gaps = 14/180 (7%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPI---RVEG-----------LSNLSLVDIAAGGWHSAALT 494
            A G+N + +LG+       +P+   +VE            L    L+ I  G  HSAA+T
Sbjct: 518  ACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVT 577

Query: 493  KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
              G+ Y +G  +HG+LG    + S   P +VQ L G  +  V+CG   +V + ++  ++S
Sbjct: 578  ASGDCYTFGSNQHGQLGTNTRRGSR-APCKVQGLEGIKMAMVACGDAFTVAIGAESEVYS 636

Query: 313  YXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVTWTD 134
            +            +   G P  V ++   P T TS           C G   LA+ + TD
Sbjct: 637  WGKGARGRLGRRDE-DAGLPRPVQLDETHPYTVTSVS--------CCHGNTLLAVRSVTD 687



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 42/174 (24%), Positives = 65/174 (37%), Gaps = 13/174 (7%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           AWG  + G+LG+G  +  S P +V          +  G   S  LT  G+  A G     
Sbjct: 466 AWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFN 525

Query: 451 RLG-----FGDDKSSHM---VPLQVQLLAG-----EDIVQVSCGGTHSVVLTSDGRIFSY 311
           +LG      G++   H      L   LL       E ++ +  G  HS  +T+ G  +++
Sbjct: 526 KLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTF 585

Query: 310 XXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
                       +  +  P +V             EG+  A  VACG   T+AI
Sbjct: 586 GSNQHGQLGTNTRRGSRAPCKV----------QGLEGIKMA-MVACGDAFTVAI 628



 Score = 37.4 bits (85), Expect = 0.037
 Identities = 40/151 (26%), Positives = 60/151 (39%), Gaps = 8/151 (5%)
 Frame = -3

Query: 571 PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAW-----GRGEHGRL-GFGDDKSSHMVP 410
           P+R+  L N  +V +AAG    A +T+ G +  W     G G    L G  +      + 
Sbjct: 324 PLRLPML-NTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFIS 382

Query: 409 LQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLP 230
             ++  +G  I  V+CG   +  LT  G I ++                GH     I+ P
Sbjct: 383 RFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNG--------CLGHGSLTDISQP 434

Query: 229 PPKTSTSSEGL--WQANYVACGGRHTLAIVT 143
                T  E L  ++   VACG  H LA+ T
Sbjct: 435 -----TIVEALLGYEMVQVACGASHVLALST 460

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>RCC2_MOUSE (Q8BK67) Protein RCC2|
          Length = 520

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 39/107 (36%), Positives = 64/107 (59%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +WG NE GQLG GDT+    P  +E LS+ ++V  A G  H+ ALT  G V+A+G  + G
Sbjct: 171 SWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLALTDTGSVFAFGENKMG 230

Query: 451 RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           +LG G+   +   P Q+ +  G+ I +++CG   S+++   G ++S+
Sbjct: 231 QLGLGNQTDAVPSPAQI-MYNGQPITKMACGAEFSMLMDCKGNLYSF 276



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 32/89 (35%), Positives = 51/89 (57%), Gaps = 2/89 (2%)
 Frame = -3

Query: 571 PIRVEGLSNLSLVDIAAGGW--HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 398
           P R   LS + +  + +G    HS  +T EG++++WGR E G+LG GD K     P  ++
Sbjct: 137 PHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVE-APRLIE 195

Query: 397 LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            L+ E IV  +CG  H++ LT  G +F++
Sbjct: 196 ALSHEAIVLAACGRNHTLALTDTGSVFAF 224



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 26/131 (19%)
 Frame = -3

Query: 631 AWGNNEYGQLGIG----------------DTQPRSQPIRVEG--------LSNLSLVDIA 524
           ++G  EYGQLG                  +  PR   I +E         + N+ + D+A
Sbjct: 275 SFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVA 334

Query: 523 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL--LAGEDIVQVSCGGTH 350
            G  H+  L  +  V++WG G +GRLG  + K   MVP  V+L    G    Q+  G T 
Sbjct: 335 CGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK-DEMVPRLVKLFDFPGRGATQIYAGYTC 393

Query: 349 SVVLTSDGRIF 317
           S  ++  G +F
Sbjct: 394 SFAVSEVGGLF 404

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>GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 458

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 47/150 (31%), Positives = 71/150 (47%), Gaps = 7/150 (4%)
 Frame = -3

Query: 574 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVP--LQV 401
           +P RV GL N   + + AG  HSA+LT  GEVY WG  +HG+L   ++ +   VP  ++ 
Sbjct: 202 EPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQL--ANEAAFLPVPQKIEA 259

Query: 400 QLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPME-----VPIN 236
                E +  +  G TH V  T  G++F++            +   G  +E     +P +
Sbjct: 260 HCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCS 319

Query: 235 LPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
            PP    +S   L  A  V+CG  H LAI+
Sbjct: 320 RPPNSMPSSPHCLTGATEVSCGSEHNLAII 349



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 2/108 (1%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSN-LSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           AWG N YGQLG+G  +    P ++       S+  I  GG HSA +T  G+++  G  + 
Sbjct: 19  AWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKD 78

Query: 454 GRLGFGDDKS-SHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
           G+LG G  +   +  P   + L G  I QV+CG   +++LT +G++ S
Sbjct: 79  GQLGLGHTEDIPYFTP--CKSLFGCPIQQVACGWDFTIMLTENGQVLS 124



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 44/178 (24%), Positives = 69/178 (38%), Gaps = 18/178 (10%)
 Frame = -3

Query: 628 WGNNEYGQL-GIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           WG+N++GQL       P  Q I      N  +  I +G  H  A T+ G+++ WGR ++G
Sbjct: 236 WGSNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYG 295

Query: 451 RLG-----------------FGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 323
           +LG                     +  + +P     L G    +VSCG  H++ +   G 
Sbjct: 296 QLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG--ATEVSCGSEHNLAIIG-GV 352

Query: 322 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
            +S+            +     P        P +   SS GL     V CG  H+LA+
Sbjct: 353 CYSWGWNEHGMCGDGTEANVWAP-------KPVQALLSSSGL----LVGCGAGHSLAL 399



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 30/105 (28%), Positives = 51/105 (48%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRL 446
           G N+ GQLG+G T+        + L    +  +A G   +  LT+ G+V + G    G+L
Sbjct: 74  GLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQL 133

Query: 445 GFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           G        +VP  ++ L  E +V ++ G  H+V  T+ G +F +
Sbjct: 134 GVPHGPRRCVVPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQW 177



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 34/109 (31%), Positives = 45/109 (41%), Gaps = 6/109 (5%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG-- 452
           G+N +GQLG+     R    +   L    +V IAAG  H+ A T  G V+ WG G     
Sbjct: 126 GSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCG 185

Query: 451 -RLGFGDDKSSHMV---PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 317
            RL  G           P +V  L     + V  G  HS  LT  G ++
Sbjct: 186 RRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVY 234



 Score = 36.6 bits (83), Expect = 0.064
 Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 1/65 (1%)
 Frame = -3

Query: 508 SAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQV-QLLAGEDIVQVSCGGTHSVVLTS 332
           S A      ++AWG   +G+LG G  K   ++P Q+        + +++ GG HS V+T 
Sbjct: 8   SEAAPAAAALFAWGANSYGQLGLG-HKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTD 66

Query: 331 DGRIF 317
            G +F
Sbjct: 67  GGDLF 71

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>RCC2_XENLA (Q52KW8) Protein RCC2 homolog|
          Length = 513

 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 39/107 (36%), Positives = 60/107 (56%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +WG N+ GQLG GD +    P  +E L     V  A G  H+ ALT+ G VYA+G  + G
Sbjct: 164 SWGRNDKGQLGHGDIKRIDVPKLIESLKGEVFVHAACGRNHTLALTENGSVYAFGENKMG 223

Query: 451 RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           +LG G+   +   P Q+ L  G+ I +V+CG   S+++   G ++S+
Sbjct: 224 QLGLGNKTDAVPSPAQI-LYNGQPITKVACGAEFSMIMDCKGNLYSF 269



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 31/89 (34%), Positives = 53/89 (59%), Gaps = 2/89 (2%)
 Frame = -3

Query: 571 PIRVEGLSNLSLVDIAAGGW--HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 398
           P R   L+ + +  +A+G    HS  +T EG++++WGR + G+LG GD K    VP  ++
Sbjct: 130 PHRYGCLTGVQVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGHGDIKRID-VPKLIE 188

Query: 397 LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            L GE  V  +CG  H++ LT +G ++++
Sbjct: 189 SLKGEVFVHAACGRNHTLALTENGSVYAF 217



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 28/79 (35%), Positives = 41/79 (51%), Gaps = 2/79 (2%)
 Frame = -3

Query: 547 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL--LAGEDIV 374
           N+ + DIA G  HS  L  +  V++WG G +GRLG  + +   MVP  V+L    G    
Sbjct: 320 NVVVRDIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQR-DEMVPRLVKLFDFPGRGAA 378

Query: 373 QVSCGGTHSVVLTSDGRIF 317
           Q+  G T S  ++  G +F
Sbjct: 379 QIYAGATCSFAVSEMGGLF 397



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 34/133 (25%), Positives = 57/133 (42%), Gaps = 26/133 (19%)
 Frame = -3

Query: 631 AWGNNEYGQLGIG---DTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRG 461
           A+G N+ GQLG+G   D  P    I   G     +  +A G   S  +  +G +Y++G  
Sbjct: 216 AFGENKMGQLGLGNKTDAVPSPAQILYNGQP---ITKVACGAEFSMIMDCKGNLYSFGCP 272

Query: 460 EHGRLGFGDDKS----SHMVPLQVQLLAGEDIV-------------------QVSCGGTH 350
           E+G+LG   D      +  +    +L+A    +                    ++CG  H
Sbjct: 273 EYGQLGHNSDGKYIARAQRIEYDCELIARRIAIFIEKTKDGQILPVPNVVVRDIACGINH 332

Query: 349 SVVLTSDGRIFSY 311
           S++L S  R+FS+
Sbjct: 333 SLILDSQKRVFSW 345

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>RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulator (mRpgr)|
          Length = 1001

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 54/163 (33%), Positives = 86/163 (52%), Gaps = 2/163 (1%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV-DIAAGGWHSAALTKEGEVYAWGRGEH 455
           A GNNE GQLG+GDT  R    ++   +    +  ++AG   SAALT++G+++ WG    
Sbjct: 111 AGGNNE-GQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDNSE 169

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G++G  +DKS+  +P +V +  G+ I  +SCG  HS  +T DG ++++            
Sbjct: 170 GQIGL-EDKSNVCIPHEVTV--GKPISWISCGYYHSAFVTMDGELYTFGEPENG------ 220

Query: 274 KVTTGHPMEVPIN-LPPPKTSTSSEGLWQANYVACGGRHTLAI 149
               G P E+ +N   P +     E + Q   VACGG HT+ +
Sbjct: 221 --KLGLPNELLMNHRSPQRVLGIPERVIQ---VACGGGHTVVL 258



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 39/99 (39%), Positives = 59/99 (59%), Gaps = 1/99 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG+N  GQ+G+ D      P  V     +S   I+ G +HSA +T +GE+Y +G  E+G+
Sbjct: 164 WGDNSEGQIGLEDKSNVCIPHEVTVGKPISW--ISCGYYHSAFVTMDGELYTFGEPENGK 221

Query: 448 LGFGDD-KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 335
           LG  ++   +H  P +V L   E ++QV+CGG H+VVLT
Sbjct: 222 LGLPNELLMNHRSPQRV-LGIPERVIQVACGGGHTVVLT 259



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 44/154 (28%), Positives = 63/154 (40%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           +G+N +GQLG+G      +P  ++ L    +   A G  H+   T  G VYA G    G+
Sbjct: 59  FGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQ 118

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKV 269
           LG GD          V     + I Q+S G   S  LT DG++F +            K 
Sbjct: 119 LGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKS 178

Query: 268 TTGHPMEVPINLPPPKTSTSSEGLWQANYVACGG 167
               P EV +  P    S  S G + + +V   G
Sbjct: 179 NVCIPHEVTVGKP---ISWISCGYYHSAFVTMDG 209



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 47/164 (28%), Positives = 74/164 (45%), Gaps = 2/164 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDT--QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           +G  E G+LG+ +        P RV G+    ++ +A GG H+  LT E  VYA+G G+ 
Sbjct: 214 FGEPENGKLGLPNELLMNHRSPQRVLGIPE-RVIQVACGGGHTVVLT-EKVVYAFGLGQF 271

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G+LG G        P  ++ +  + I  +SCG  H+ ++T  G ++++            
Sbjct: 272 GQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHG------ 325

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVT 143
               G  ME   N   P T  S+   +    +ACGG H L   T
Sbjct: 326 --KLGLGMENFTNQFFP-TLCSNFLRFAVQLIACGGCHMLVFAT 366



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/102 (29%), Positives = 55/102 (53%), Gaps = 2/102 (1%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGD-TQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           A+G  ++GQLG+G      S+P  +E + +  +  I+ G  H+A +T+ G +Y +G G H
Sbjct: 265 AFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRH 324

Query: 454 GRLGFG-DDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 332
           G+LG G ++ ++   P          +  ++CGG H +V  +
Sbjct: 325 GKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGGCHMLVFAT 366



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 20/72 (27%), Positives = 40/72 (55%)
 Frame = -3

Query: 529 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH 350
           ++ G  H+A +T   ++Y +G    G+LG G  K++ + P  ++ L  E +   +CG  H
Sbjct: 40  LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLG-SKAAIIKPTCIKALKPEKVKLAACGRNH 98

Query: 349 SVVLTSDGRIFS 314
           ++V T  G +++
Sbjct: 99  TLVSTDTGGVYA 110

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>ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1657

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 36/97 (37%), Positives = 56/97 (57%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG  + GQLG GD  PR QP+ V+ L    ++ + AGG+HS ALT + +VY+WG    G+
Sbjct: 531 WGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQ 590

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 338
           LG  D  ++  VP   ++ +   +  V+ G  +S+ L
Sbjct: 591 LGHSDFPTT--VPRLAKISSENGVWSVAAGRDYSLFL 625



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 36/122 (29%), Positives = 61/122 (50%)
 Frame = -3

Query: 484 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXX 305
           EV+ WG+G+ G+LG GD     + PL V+ L G++++ +  GG HS+ LT+  +++S+  
Sbjct: 527 EVWTWGKGKEGQLGHGD-VLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGS 585

Query: 304 XXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVTWTDM*L 125
                         GH  + P  +P     +S  G+W    VA G  ++L +V   D   
Sbjct: 586 NTFG--------QLGH-SDFPTTVPRLAKISSENGVWS---VAAGRDYSLFLVDTEDFQP 633

Query: 124 GI 119
           G+
Sbjct: 634 GL 635



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 37/150 (24%), Positives = 61/150 (40%), Gaps = 6/150 (4%)
 Frame = -3

Query: 577 SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK------SSHM 416
           S PI    L    +V +A G +HS A+T  G  Y WG    G+    + +         +
Sbjct: 80  SSPILENALVGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSI 139

Query: 415 VPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPIN 236
              +   L    I+Q++CG  H++ L+    I+++             +TT      P+ 
Sbjct: 140 ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGL-----ITTA----FPVT 190

Query: 235 LPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
            P      +   + Q   VACG  H+LA+V
Sbjct: 191 KPQKVEHLAGRVVLQ---VACGAFHSLALV 217



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 42/160 (26%), Positives = 64/160 (40%), Gaps = 7/160 (4%)
 Frame = -3

Query: 571 PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 392
           P R+ G    +++  A G  H   LT++GEVY++G         G  +     P+    L
Sbjct: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENAL 88

Query: 391 AGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTST 212
            G+ +V V+ G  HS  +T +G  + +            +     P  V I      +  
Sbjct: 89  VGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSI----ADSEA 144

Query: 211 SSEGLWQANYVACGGRHTLA------IVTW-TDM*LGIIT 113
           S     +   +ACG  HTLA      I  W T   LG+IT
Sbjct: 145 SPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLIT 184



 Score = 32.7 bits (73), Expect = 0.92
 Identities = 17/61 (27%), Positives = 29/61 (47%)
 Frame = -3

Query: 493 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
           K     A G  E G +      S  + P ++    G+ ++Q + G  H V+LT DG ++S
Sbjct: 5   KRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64

Query: 313 Y 311
           +
Sbjct: 65  F 65

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>ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)|
          Length = 1657

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 35/97 (36%), Positives = 56/97 (57%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG  + GQLG GD  PR QP+ V+ L    ++ + AGG+HS ALT + +VY+WG    G+
Sbjct: 531 WGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQ 590

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 338
           LG  D  ++  VP   ++ +   +  ++ G  +S+ L
Sbjct: 591 LGHSDFPTT--VPRLAKISSENGVWSIAAGRDYSLFL 625



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 35/122 (28%), Positives = 61/122 (50%)
 Frame = -3

Query: 484 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXX 305
           EV+ WG+G+ G+LG GD     + PL V+ L G++++ +  GG HS+ LT+  +++S+  
Sbjct: 527 EVWTWGKGKEGQLGHGD-VLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGS 585

Query: 304 XXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVTWTDM*L 125
                         GH  + P  +P     +S  G+W    +A G  ++L +V   D   
Sbjct: 586 NTFG--------QLGH-SDFPTTVPRLAKISSENGVWS---IAAGRDYSLFLVDTEDFQP 633

Query: 124 GI 119
           G+
Sbjct: 634 GL 635



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 36/150 (24%), Positives = 61/150 (40%), Gaps = 6/150 (4%)
 Frame = -3

Query: 577 SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK------SSHM 416
           S PI    L    ++ +A G +HS A+T  G  Y WG    G+    + +         +
Sbjct: 80  SSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSI 139

Query: 415 VPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPIN 236
              +   L    I+Q++CG  H++ L+    I+++             +TT      P+ 
Sbjct: 140 ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGL-----ITTA----FPVT 190

Query: 235 LPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
            P      +   + Q   VACG  H+LA+V
Sbjct: 191 KPQKVEHLAGRVVLQ---VACGAFHSLALV 217



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 7/160 (4%)
 Frame = -3

Query: 571 PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 392
           P R+ G    +++  A G  H   LT++GEVY++G         G  +     P+    L
Sbjct: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENAL 88

Query: 391 AGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTST 212
            G+ ++ V+ G  HS  +T +G  + +            +     P  V I      +  
Sbjct: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSI----ADSEA 144

Query: 211 SSEGLWQANYVACGGRHTLA------IVTW-TDM*LGIIT 113
           S     +   +ACG  HTLA      I  W T   LG+IT
Sbjct: 145 SPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLIT 184



 Score = 32.7 bits (73), Expect = 0.92
 Identities = 17/61 (27%), Positives = 29/61 (47%)
 Frame = -3

Query: 493 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
           K     A G  E G +      S  + P ++    G+ ++Q + G  H V+LT DG ++S
Sbjct: 5   KRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64

Query: 313 Y 311
           +
Sbjct: 65  F 65

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>RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1) (Chronic lymphocytic leukemia deletion region
           gene 7 protein) (CLL deletion region gene 7 protein)
          Length = 531

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 37/108 (34%), Positives = 61/108 (56%), Gaps = 1/108 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLS-LVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           AWG N  GQ+G G T  +  P +V    ++  +V IA G   S A+   GEVY WG   +
Sbjct: 151 AWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGN 210

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           G+LG G++  + + P++V  L    + Q+ CG  H++ LT +G ++++
Sbjct: 211 GQLGLGNN-GNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAW 257



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 36/108 (33%), Positives = 57/108 (52%), Gaps = 1/108 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRV-EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           AWG+N Y QLG G T     P++V   L    +V++A G  HS AL  +GEV+AWG    
Sbjct: 98  AWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNC 157

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           G++G G   +          L  + +V ++CG T S+ +  +G ++ +
Sbjct: 158 GQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGW 205



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 48/163 (29%), Positives = 80/163 (49%), Gaps = 2/163 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHG 452
           +G N    LG GD Q    P ++EGL    +  ++ G G H    T++G VYAWG   + 
Sbjct: 46  FGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYS 105

Query: 451 RLGFGDDKSSHMVPLQV-QLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           +LG G      + P+QV   L  + +V+V+CG  HS+ L +DG +F++            
Sbjct: 106 QLGNGTTNQG-IAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAW------GYNNCG 158

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
           +V +G       N P P+  T+   + +   +ACG   ++A++
Sbjct: 159 QVGSGS----TANQPTPRKVTNCLHIKRVVGIACGQTSSMAVL 197



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 37/108 (34%), Positives = 62/108 (57%), Gaps = 2/108 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG N  GQLG+G+   +  P+RV  L ++ +  I  G  H+ ALT EG +YAWG   +G+
Sbjct: 205 WGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQ 264

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQV-SCGGTH-SVVLTSDGRIFSY 311
           LG G +K++ + P  + ++  E +V++ +C   H S   T  G ++ +
Sbjct: 265 LGTG-NKNNLLSPAHI-MVEKERVVEIAACHSAHTSAAKTQGGHVYMW 310



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 32/118 (27%), Positives = 56/118 (47%), Gaps = 1/118 (0%)
 Frame = -3

Query: 499 LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCG-GTHSVVLTSDGR 323
           +T   EV+ +G      LG GD++S+ +VP +++ L G+ I  +S G G H ++ T DG 
Sbjct: 37  VTDNDEVFVFGLNYSNCLGTGDNQST-LVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGV 95

Query: 322 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
           ++++                  P++V  NL           + Q   VACG  H++A+
Sbjct: 96  VYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL----------IKQVVEVACGSHHSMAL 143



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 24/58 (41%), Positives = 31/58 (53%), Gaps = 2/58 (3%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGR 464
           AWG N YGQLG G+      P  +  +    +V+IAA      SAA T+ G VY WG+
Sbjct: 256 AWGANTYGQLGTGNKNNLLSPAHIM-VEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312

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>RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 48/148 (32%), Positives = 79/148 (53%), Gaps = 5/148 (3%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           G  + GQLG+G++   R +P  V  L ++  V   AGG H+  L + G+VY++G  + G 
Sbjct: 41  GQGDVGQLGLGESVLERKKPALVPLLQDV--VQAEAGGMHTVCLNQSGQVYSFGCNDEGA 98

Query: 448 LGFGDD-KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF---SYXXXXXXXXXX 281
           LG     + S MVP +V+L   E +VQVS G +H+  LT DGR+F   S+          
Sbjct: 99  LGRDTSVEGSEMVPGKVELQ--EKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLL 156

Query: 280 XRKVTTGHPMEVPINLPPPKTSTSSEGL 197
                +  P++V +++P  K ++ ++ L
Sbjct: 157 EPMKKSMVPVQVQLDMPVVKVASGNDHL 184



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 42/163 (25%), Positives = 69/163 (42%), Gaps = 2/163 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNL--SLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           +G + Y QLG   T     P  +    N   S V  + G  H+  +  EG+ Y+ GR E+
Sbjct: 264 FGLSNYHQLGTPGTASCFIPQNLTSFKNSTKSWVGFSGGQHHTICMDSEGKAYSLGRAEY 323

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           GRLG G+      +P  +  L    +  V+CG +    ++ DGR+F++           +
Sbjct: 324 GRLGLGEGAEEKSIPTLISRL--PVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQ 381

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
                 P+E+        T    E       V+ GG+HT+ +V
Sbjct: 382 DEDAWSPVEM--------TGKQLENRVVLT-VSSGGQHTVLLV 415



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 24/67 (35%), Positives = 37/67 (55%)
 Frame = -3

Query: 511 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 332
           H +  T+ G V   G+G+ G+LG G+       P  V LL  +D+VQ   GG H+V L  
Sbjct: 27  HRSHKTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLL--QDVVQAEAGGMHTVCLNQ 84

Query: 331 DGRIFSY 311
            G+++S+
Sbjct: 85  SGQVYSF 91



 Score = 33.9 bits (76), Expect = 0.41
 Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEG--LSNLSLVDIAAGGWHSAALTKEGE 482
           AWG     QLG G  +    P+ + G  L N  ++ +++GG H+  L K+ E
Sbjct: 368 AWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLVKDKE 419

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>RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1020

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 48/162 (29%), Positives = 78/162 (48%), Gaps = 1/162 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGL-SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           A G N  GQLG+GDT+ R+    +    S   +  ++AG   SAALT++G ++ WG    
Sbjct: 110 ATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSE 169

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G++G   + S+  VP QV +  G+ +  +SCG  HS  +T+DG ++ +            
Sbjct: 170 GQIGL-KNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPN 226

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
           ++   H     ++  P K             VACGG HT+ +
Sbjct: 227 QLLGNHRTPQLVSEIPEKVI----------QVACGGEHTVVL 258



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 44/162 (27%), Positives = 68/162 (41%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           +G+N +GQLG+G     S+P  V+ L    +   A G  H+   T+ G VYA G    G+
Sbjct: 59  FGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQ 118

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKV 269
           LG GD +  +   +     +   I Q+S G   S  LT DGR+F +              
Sbjct: 119 LGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVS 178

Query: 268 TTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVT 143
               P +V I  P              ++++CG  H+  + T
Sbjct: 179 NVCVPQQVTIGKP-------------VSWISCGYYHSAFVTT 207



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 37/101 (36%), Positives = 59/101 (58%), Gaps = 1/101 (0%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG+N  GQ+G+ +      P +V     +S   I+ G +HSA +T +GE+Y +G  E+G+
Sbjct: 164 WGDNSEGQIGLKNVSNVCVPQQVTIGKPVSW--ISCGYYHSAFVTTDGELYVFGEPENGK 221

Query: 448 LGFGDD-KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSD 329
           LG  +    +H  P  V  +  E ++QV+CGG H+VVLT +
Sbjct: 222 LGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTEN 261



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 33/104 (31%), Positives = 57/104 (54%), Gaps = 2/104 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +G  ++GQLG+G      S+P  +E + + ++  I+ G  H+A +T  G +Y +G G HG
Sbjct: 266 FGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHG 325

Query: 451 RLGFG-DDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 323
           +LG G ++ ++H +P          +  V+CGG H VV  +  R
Sbjct: 326 KLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHR 369



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 33/126 (26%), Positives = 56/126 (44%)
 Frame = -3

Query: 538 LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCG 359
           ++ +A GG H+  LT E  VY +G G+ G+LG G        P  ++ +  + I  +SCG
Sbjct: 245 VIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCG 303

Query: 358 GTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYV 179
             H+ ++T  G ++++            +  T H +          T  S+   +    V
Sbjct: 304 ENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFI---------PTLCSNFLRFIVKLV 354

Query: 178 ACGGRH 161
           ACGG H
Sbjct: 355 ACGGCH 360



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 24/74 (32%), Positives = 40/74 (54%)
 Frame = -3

Query: 535 VDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG 356
           V ++ G  HSA +T   ++Y +G    G+LG G  KS+   P  V+ L  E +   +CG 
Sbjct: 38  VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG-SKSAISKPTCVKALKPEKVKLAACGR 96

Query: 355 THSVVLTSDGRIFS 314
            H++V T  G +++
Sbjct: 97  NHTLVSTEGGNVYA 110

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>RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromosome|
           condensation protein 1) (Cell cycle regulatory protein)
          Length = 421

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 48/148 (32%), Positives = 78/148 (52%), Gaps = 5/148 (3%)
 Frame = -3

Query: 625 GNNEYGQLGIGDT-QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           G  + GQLG+G+    R +P  V    ++  V   AGG H+  L+K G+VY++G  + G 
Sbjct: 41  GQGDVGQLGLGENVMERKKPALVSIPEDV--VQAEAGGMHTVCLSKSGQVYSFGCNDEGA 98

Query: 448 LGFGDD-KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF---SYXXXXXXXXXX 281
           LG     + S MVP +V+L   E +VQVS G +H+  LT DGR+F   S+          
Sbjct: 99  LGRDTSVEGSEMVPGKVEL--QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLL 156

Query: 280 XRKVTTGHPMEVPINLPPPKTSTSSEGL 197
                +  P++V +++P  K ++ ++ L
Sbjct: 157 EPMKKSMVPVQVQLDVPVVKVASGNDHL 184



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 42/163 (25%), Positives = 70/163 (42%), Gaps = 2/163 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNL--SLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           +G + Y QLG   T+    P  +    N   S V  + G  H+  +  EG+ Y+ GR E+
Sbjct: 264 FGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 323

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           GRLG G+      +P  +  L    +  V+CG +    +T DGR+F++           +
Sbjct: 324 GRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQ 381

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
                 P+E+       +   S         V+ GG+HT+ +V
Sbjct: 382 DEDAWSPVEMMGKQLENRVVLS---------VSSGGQHTVLLV 415



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 23/67 (34%), Positives = 38/67 (56%)
 Frame = -3

Query: 511 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 332
           H +  T+ G V   G+G+ G+LG G++      P  V +   ED+VQ   GG H+V L+ 
Sbjct: 27  HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSK 84

Query: 331 DGRIFSY 311
            G+++S+
Sbjct: 85  SGQVYSF 91



 Score = 33.9 bits (76), Expect = 0.41
 Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEG--LSNLSLVDIAAGGWHSAALTKEGE 482
           AWG     QLG G  +    P+ + G  L N  ++ +++GG H+  L K+ E
Sbjct: 368 AWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKE 419

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>RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1)
          Length = 531

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 44/162 (27%), Positives = 71/162 (43%), Gaps = 1/162 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRV-EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           AWG+N Y QLG G T     P++V   L    ++++A G  HS AL  +GE++AWG    
Sbjct: 98  AWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEVACGSHHSMALAADGELFAWGYNNC 157

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           G++G G   +          L  + +V ++CG T S+ +   G ++ +            
Sbjct: 158 GQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTSSMAVLDSGEVYGWGYNGNGQLGLGN 217

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
                 P+ V           +  G+   N + CG  HTLA+
Sbjct: 218 NGNQLTPVRV----------AALHGMC-VNQIVCGYAHTLAL 248



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 38/107 (35%), Positives = 57/107 (53%), Gaps = 1/107 (0%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG N  GQLG+G+   +  P+RV  L  + +  I  G  H+ ALT EG +YAWG   +G+
Sbjct: 205 WGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWGANTYGQ 264

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH-SVVLTSDGRIFSY 311
           LG G  K++ + P Q+ +     I   +C  TH S   T  G ++ +
Sbjct: 265 LGTG-SKNNLLSPTQIMVEKERVIEIAACHSTHTSAAKTQGGHVYMW 310



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 46/163 (28%), Positives = 78/163 (47%), Gaps = 2/163 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHG 452
           +G N    LG GD Q    P ++E L    +  ++ G G H    T++G VYAWG   + 
Sbjct: 46  FGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSLSYGSGPHVLLTTEDGVVYAWGHNGYS 105

Query: 451 RLGFGDDKSSHMVPLQV-QLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           +LG G      + P+QV   L  + +++V+CG  HS+ L +DG +F++            
Sbjct: 106 QLGNGTTNQG-IAPVQVCTNLLIKQVIEVACGSHHSMALAADGELFAW------GYNNCG 158

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
           +V +G       N P P+  T+     +   +ACG   ++A++
Sbjct: 159 QVGSGS----TANQPTPRKVTNCLHTKRVVNIACGQTSSMAVL 197



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 32/118 (27%), Positives = 56/118 (47%), Gaps = 1/118 (0%)
 Frame = -3

Query: 499 LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCG-GTHSVVLTSDGR 323
           +T   EV+ +G      LG GD++S+ +VP +++ L G+ I  +S G G H ++ T DG 
Sbjct: 37  VTDNDEVFVFGLNYSNCLGTGDNQST-LVPKKLEALCGKKIKSLSYGSGPHVLLTTEDGV 95

Query: 322 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
           ++++                  P++V  NL           + Q   VACG  H++A+
Sbjct: 96  VYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL----------IKQVIEVACGSHHSMAL 143



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 23/58 (39%), Positives = 31/58 (53%), Gaps = 2/58 (3%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGR 464
           AWG N YGQLG G       P ++  +    +++IAA      SAA T+ G VY WG+
Sbjct: 256 AWGANTYGQLGTGSKNNLLSPTQIM-VEKERVIEIAACHSTHTSAAKTQGGHVYMWGQ 312

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>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)|
           (NimA-related protein kinase 8)
          Length = 697

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 39/105 (37%), Positives = 60/105 (57%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           +G+   G LG G+    +QP  VE L    LV ++ G  H  A+T E EV++WGRG++GR
Sbjct: 422 FGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGASHVLAVTNEREVFSWGRGDNGR 481

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
           LG    + SH  P QV L A  +  +V CG   S+++++  +I +
Sbjct: 482 LGLA-TQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMSTQHQILA 525



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 44/175 (25%), Positives = 74/175 (42%), Gaps = 14/175 (8%)
 Frame = -3

Query: 631  AWGNNEYGQLGI----GDTQPRS----------QPIRVEGLSNLSLVDIAAGGWHSAALT 494
            A GNN + +LG+    G  +P S          Q ++   L+   +V I  G  HS A+T
Sbjct: 525  ACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTEKIVYIDIGTAHSVAVT 584

Query: 493  KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
            ++G+ + +G  +HG+LG    +SS  VP QV  L G  I   +CG   ++ + ++G +++
Sbjct: 585  EKGQCFTFGSNQHGQLGCSHRRSSR-VPYQVSGLQG--ITMAACGDAFTLAIGAEGEVYT 641

Query: 313  YXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
            +                    E    +P P     S      +   C G   LA+
Sbjct: 642  WGKGARGRLGR---------KEEDFGIPKPVQLDESHAFTVTSVACCHGNTLLAV 687



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 29/92 (31%), Positives = 51/92 (55%)
 Frame = -3

Query: 586 QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPL 407
           QP+     +EG S +++  ++ G   +  LT  G +  +G G +G LG G+       P 
Sbjct: 384 QPQFISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQ-PK 442

Query: 406 QVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            V+ L G ++VQVSCG +H + +T++  +FS+
Sbjct: 443 IVEALLGYELVQVSCGASHVLAVTNEREVFSW 474



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 40/174 (22%), Positives = 67/174 (38%), Gaps = 13/174 (7%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +WG  + G+LG+      + P +V   ++     +  G   S  ++ + ++ A G     
Sbjct: 473 SWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMSTQHQILACGNNRFN 532

Query: 451 RLGF----GDDKSS--------HMVPL-QVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           +LG     G ++ S        H+  L Q   L  E IV +  G  HSV +T  G+ F++
Sbjct: 533 KLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTEKIVYIDIGTAHSVAVTEKGQCFTF 592

Query: 310 XXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
                       + ++  P +V              GL      ACG   TLAI
Sbjct: 593 GSNQHGQLGCSHRRSSRVPYQV-------------SGLQGITMAACGDAFTLAI 633

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>RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 48/148 (32%), Positives = 79/148 (53%), Gaps = 5/148 (3%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           G  + GQLG+G++   R +P  V  L ++  V   AGG H+  L++ G+VY++G  + G 
Sbjct: 41  GQGDVGQLGLGESVLERKKPALVPLLQDV--VQAEAGGMHTVCLSQSGQVYSFGCNDEGA 98

Query: 448 LGFGDD-KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF---SYXXXXXXXXXX 281
           LG     + S MVP +V+L   E +VQVS G +H+  LT DGR+F   S+          
Sbjct: 99  LGRDTSVEGSEMVPGKVELQ--EKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLL 156

Query: 280 XRKVTTGHPMEVPINLPPPKTSTSSEGL 197
                +  P++V ++ P  K ++ ++ L
Sbjct: 157 EPMKKSMVPVQVQLDAPVVKVASGNDHL 184



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 42/163 (25%), Positives = 69/163 (42%), Gaps = 2/163 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNL--SLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           +G + Y QLG   T     P  +    N   S V  + G  H+  +  EG+ Y+ GR E+
Sbjct: 264 FGLSNYHQLGTPGTGSCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 323

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           GRLG G+      +P  +  L    +  V+CG +    ++ DGR+F++           +
Sbjct: 324 GRLGLGEGAEEKSIPTLISRL--PVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQ 381

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
                 P+E+        T    E       V+ GG+HT+ +V
Sbjct: 382 DEDAWSPVEM--------TGKQLENRVVLT-VSSGGQHTVLLV 415



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 24/67 (35%), Positives = 38/67 (56%)
 Frame = -3

Query: 511 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 332
           H +  T+ G V   G+G+ G+LG G+       P  V LL  +D+VQ   GG H+V L+ 
Sbjct: 27  HRSHNTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLL--QDVVQAEAGGMHTVCLSQ 84

Query: 331 DGRIFSY 311
            G+++S+
Sbjct: 85  SGQVYSF 91



 Score = 32.7 bits (73), Expect = 0.92
 Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEG--LSNLSLVDIAAGGWHSAALTKE 488
           AWG     QLG G  +    P+ + G  L N  ++ +++GG H+  L K+
Sbjct: 368 AWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLVKD 417

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>RCC1_XENLA (P25183) Regulator of chromosome condensation|
          Length = 424

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 49/148 (33%), Positives = 74/148 (50%), Gaps = 5/148 (3%)
 Frame = -3

Query: 625 GNNEYGQLGIG-DTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           G  + GQLG+G D   R +P  V    ++  V  AAGG H+  L   G +Y +G  + G 
Sbjct: 47  GQGDVGQLGLGEDIMERKKPALVTLTEDI--VQAAAGGMHTVCLGASGSIYTFGCNDEGA 104

Query: 448 LGFG-DDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF---SYXXXXXXXXXX 281
           LG    ++ S M P +V+L   E +VQVS G +H+  LT DGR+F   S+          
Sbjct: 105 LGRDTSEEGSEMQPGKVEL--AEKVVQVSAGDSHTAALTEDGRVFVFGSFRDNNGVIGLL 162

Query: 280 XRKVTTGHPMEVPINLPPPKTSTSSEGL 197
                +  P++V IN P  K ++ ++ L
Sbjct: 163 EPMKKSMVPVQVQINTPVIKIASGNDHL 190



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 43/163 (26%), Positives = 72/163 (44%), Gaps = 2/163 (1%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNL--SLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           +G + Y QLG  +TQ    P  +    N   S +  + G  H+  +  EG+ Y+ GR E+
Sbjct: 269 FGLSNYHQLGTKNTQACYAPQNLTSFKNSTKSWIGFSGGQHHTVCVDSEGKAYSLGRAEY 328

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 275
           GRLG G++      P  +  L    I  V+ G + S  +++DG +F++            
Sbjct: 329 GRLGLGENAEEQSEPTPIPDL--PKINSVASGASVSYAVSTDGCVFAW--------GMGT 378

Query: 274 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
            +  G   E  +  P   T    E   +   V+ GG+HT+ +V
Sbjct: 379 NLQLGTGEEEDVWSPEQMTGKHLEDR-EVLSVSSGGQHTVLLV 420



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 26/67 (38%), Positives = 38/67 (56%)
 Frame = -3

Query: 511 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 332
           H +  T  G+V   G+G+ G+LG G+D      P  V L   EDIVQ + GG H+V L +
Sbjct: 33  HPSHGTVGGQVLTLGQGDVGQLGLGEDIMERKKPALVTLT--EDIVQAAAGGMHTVCLGA 90

Query: 331 DGRIFSY 311
            G I+++
Sbjct: 91  SGSIYTF 97

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>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase)
          Length = 944

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 36/106 (33%), Positives = 56/106 (52%), Gaps = 1/106 (0%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRL 446
           G+  +GQLG GD     QP  VE L   S+  ++ G   +  +T EG++Y++G   +G L
Sbjct: 381 GSKLHGQLGHGDRASYRQPKHVEKLQGKSVQKVSCGSDFTVCITDEGQLYSFGSDYYGCL 440

Query: 445 GFGDDKSSHMV-PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           G      S ++ PL V     E + QVSCG +H + LT    ++S+
Sbjct: 441 GVNQSAGSEVLEPLLVDFFLNEPVDQVSCGDSHIMALTRSKSVYSW 486



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 36/108 (33%), Positives = 59/108 (54%), Gaps = 2/108 (1%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRS--QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 458
           ++G++ YG LG+  +      +P+ V+   N  +  ++ G  H  ALT+   VY+WG GE
Sbjct: 431 SFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSCGDSHIMALTRSKSVYSWGCGE 490

Query: 457 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
           +GRLG  D +     P +V++  G  IV V CG   S +LT  G++ +
Sbjct: 491 YGRLGL-DSEDDVYSPQKVEVQRGLCIVNVCCGSDGSFLLTLTGKVLA 537



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 35/119 (29%), Positives = 54/119 (45%), Gaps = 12/119 (10%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +WG  EYG+LG+        P +VE    L +V++  G   S  LT  G+V A G  EH 
Sbjct: 485 SWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCGSDGSFLLTLTGKVLACGLNEHN 544

Query: 451 RLGFG-------DDKSSHMVPLQVQL-----LAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           +LG         + ++   VP    L     L+   I  +S G TH+  +   GR+ ++
Sbjct: 545 KLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKIRSISPGRTHTAAIDERGRLLTF 603



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 25/81 (30%), Positives = 44/81 (54%)
 Frame = -3

Query: 553 LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV 374
           LS   +  I+ G  H+AA+ + G +  +G  + G+LG GD +    + L    L G+ ++
Sbjct: 576 LSFYKIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVI 635

Query: 373 QVSCGGTHSVVLTSDGRIFSY 311
           +VSCG   +   T+D  IF++
Sbjct: 636 RVSCGDEFTTAATADNHIFAW 656



 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 28/106 (26%), Positives = 51/106 (48%), Gaps = 9/106 (8%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +G+N+ GQLG+GD +       + G L    ++ ++ G   + A T +  ++AWG G +G
Sbjct: 603 FGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSCGDEFTTAATADNHIFAWGNGGNG 662

Query: 451 RLGF--------GDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 338
           RL           D  +S   P+   L     +  +SC G H++++
Sbjct: 663 RLAMTPNERPQGSDICTSWPRPIFGSL---HHVTDLSCRGWHTILI 705

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>RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regulator homolog|
          Length = 1392

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 38/105 (36%), Positives = 63/105 (60%), Gaps = 1/105 (0%)
 Frame = -3

Query: 631  AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
            AWG N +GQ G+G +   +   +V+G    ++  IA G +HSA +  +G ++ +G G  G
Sbjct: 799  AWGGNRFGQCGVGHSFRIANLHQVDG-DWPAIEKIACGQFHSAFICSDGSLWTFGWGVWG 857

Query: 451  RLGFGD-DKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRI 320
            +LG G  + S+ +VP +V  L  + + Q++CG  H+VVLT  GR+
Sbjct: 858  QLGHGGRNNSNQLVPTRVNGLICK-VTQIACGRAHTVVLTDTGRV 901



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 31/77 (40%), Positives = 45/77 (58%)
 Frame = -3

Query: 541  SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 362
            ++V +A G  HSA +T EG +Y WG+G   +LG G +K+  M P QV    G   V VS 
Sbjct: 1023 NIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHG-NKNERMEPHQVFEPNGAKWVNVSL 1081

Query: 361  GGTHSVVLTSDGRIFSY 311
            G  H++  T DG +F++
Sbjct: 1082 GNNHTIASTDDGSVFAW 1098



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 39/110 (35%), Positives = 52/110 (47%), Gaps = 4/110 (3%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQ--PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
            WG   +GQLG G     +Q  P RV GL    +  IA G  H+  LT  G V   G G +
Sbjct: 853  WG--VWGQLGHGGRNNSNQLVPTRVNGLI-CKVTQIACGRAHTVVLTDTGRVLVCGSGSY 909

Query: 454  GRLGFGDD--KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            G++G  DD  K     PL +  L   DI   +    HS+ +T D R+F +
Sbjct: 910  GQMGVDDDIKKVFAFTPLPLGPLRVRDI---ATHYYHSICITEDNRVFEW 956



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 21/62 (33%), Positives = 34/62 (54%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
            WG     QLG G+   R +P +V   +    V+++ G  H+ A T +G V+AWG+ + G+
Sbjct: 1046 WGKGLDYQLGHGNKNERMEPHQVFEPNGAKWVNVSLGNNHTIASTDDGSVFAWGKNDFGQ 1105

Query: 448  LG 443
             G
Sbjct: 1106 CG 1107



 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 34/142 (23%), Positives = 59/142 (41%), Gaps = 37/142 (26%)
 Frame = -3

Query: 625  GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRG----- 461
            G+  YGQ+G+ D   +        L  L + DIA   +HS  +T++  V+ WGR      
Sbjct: 905  GSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDIATHYYHSICITEDNRVFEWGRNPQELK 964

Query: 460  ---------EHGRLGFGDDKSSHM-----------------VP------LQVQLLAGEDI 377
                        +L   +D SS                   +P       +V+     +I
Sbjct: 965  MRMFVMKKIRSAQLKNTEDPSSPSPSTNGSTPRVNLNLPAEIPREDLGLREVKHFLDGNI 1024

Query: 376  VQVSCGGTHSVVLTSDGRIFSY 311
            V V+CG +HS ++TS+G ++++
Sbjct: 1025 VSVACGLSHSALITSEGTLYTW 1046



 Score = 38.1 bits (87), Expect = 0.022
 Identities = 22/73 (30%), Positives = 35/73 (47%)
 Frame = -3

Query: 529 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH 350
           IA G  H   L+  G++ AWG    G+ G G   S  +  L         I +++CG  H
Sbjct: 781 IACGAEHILVLSSSGQLSAWGGNRFGQCGVGH--SFRIANLHQVDGDWPAIEKIACGQFH 838

Query: 349 SVVLTSDGRIFSY 311
           S  + SDG ++++
Sbjct: 839 SAFICSDGSLWTF 851

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>ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1651

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 35/97 (36%), Positives = 55/97 (56%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           WG  + GQLG GD  PR QP+ V+ L    ++ + AGG HS ALT + +VY+WG    G+
Sbjct: 525 WGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNTFGQ 584

Query: 448 LGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 338
           LG  +  ++  VP   ++ +   +  V+ G  +S+ L
Sbjct: 585 LGHSEFPTT--VPRLSKVSSENGVWSVAAGQDYSLFL 619



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 37/122 (30%), Positives = 62/122 (50%)
 Frame = -3

Query: 484 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXX 305
           EV+ WG+G+ G+LG GD     + PL V+ L G++++ +  GG+HS+ LT+  +++S+  
Sbjct: 521 EVWTWGKGKEGQLGHGD-VLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGS 579

Query: 304 XXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVTWTDM*L 125
                         GH  E P  +P     +S  G+W    VA G  ++L +V   D   
Sbjct: 580 NTFG--------QLGH-SEFPTTVPRLSKVSSENGVWS---VAAGQDYSLFLVDTEDFQP 627

Query: 124 GI 119
           G+
Sbjct: 628 GL 629



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 43/164 (26%), Positives = 66/164 (40%), Gaps = 11/164 (6%)
 Frame = -3

Query: 571 PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWG----RGEHGRLGFGDDKSSHMVPLQ 404
           P R+ G    +++  A G  H   LT++GEVY++G    + E   +           PL 
Sbjct: 32  PERLPGWGGKTVLQAALGVRHGVLLTEDGEVYSFGTLPWKSESAEI-------CPSSPLL 84

Query: 403 VQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPP 224
              L G  ++ V+ G  HS  +T  G ++ +            +     P  V I+    
Sbjct: 85  ESALVGHHVITVATGSFHSGAVTESGVVYMWGENAAGQCAVANQQYVPEPSPVSIS---- 140

Query: 223 KTSTSSEGLWQANYVACGGRHTLA------IVTW-TDM*LGIIT 113
            + TS     +   +ACG  HTLA      I  W T   LG+IT
Sbjct: 141 DSETSPSLAVRILQLACGEEHTLALSLSREIWAWGTGCQLGLIT 184



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 38/151 (25%), Positives = 64/151 (42%), Gaps = 7/151 (4%)
 Frame = -3

Query: 577 SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 398
           S P+    L    ++ +A G +HS A+T+ G VY WG    G+    + +     P  V 
Sbjct: 80  SSPLLESALVGHHVITVATGSFHSGAVTESGVVYMWGENAAGQCAVANQQYV-PEPSPVS 138

Query: 397 LLAGED-------IVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPI 239
           +   E        I+Q++CG  H++ L+    I+++             +TT      P+
Sbjct: 139 ISDSETSPSLAVRILQLACGEEHTLALSLSREIWAWGTGCQLGL-----ITT----TFPV 189

Query: 238 NLPPPKTSTSSEGLWQANYVACGGRHTLAIV 146
             P      +   + Q   VACG  H+LA+V
Sbjct: 190 TKPQKVEHLAGRVVLQ---VACGAFHSLALV 217



 Score = 33.5 bits (75), Expect = 0.54
 Identities = 17/61 (27%), Positives = 30/61 (49%)
 Frame = -3

Query: 493 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
           K+    A G  E G +      S  + P ++    G+ ++Q + G  H V+LT DG ++S
Sbjct: 5   KKSSTEAEGSKERGLVHVWQAGSFSLTPERLPGWGGKTVLQAALGVRHGVLLTEDGEVYS 64

Query: 313 Y 311
           +
Sbjct: 65  F 65

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>GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 464

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 46/152 (30%), Positives = 69/152 (45%), Gaps = 9/152 (5%)
 Frame = -3

Query: 574 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 395
           +P RV GL N + V   AG  HSA+LT  GE+Y WGR +HG+L       +  +PL  ++
Sbjct: 202 EPSRVTGLENSTAVCAVAGSDHSASLTDTGELYVWGRNKHGQLA----SRAVFLPLPQRI 257

Query: 394 LA----GEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGH-PMEVPINL- 233
            A     E +  V  G TH V  T  G++F++            +      P+E   +L 
Sbjct: 258 EAHYFQDEKVTAVWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLA 317

Query: 232 ---PPPKTSTSSEGLWQANYVACGGRHTLAIV 146
              P     +    L  A  ++CG  H LA++
Sbjct: 318 FQGPQNSVPSPLHCLTGATEISCGSEHNLAVI 349



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 34/107 (31%), Positives = 55/107 (51%), Gaps = 1/107 (0%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV-DIAAGGWHSAALTKEGEVYAWGRGEH 455
           AWG N YGQLG+G  +    P ++        +  +  GG HSA +T  G+++  G  + 
Sbjct: 19  AWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDLFVCGLNKD 78

Query: 454 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
           G+LG G  +      +  + L G  I QV+CG   +++LT  G++ S
Sbjct: 79  GQLGLGHTEEVLRFTI-CKPLRGCPIRQVACGWDFTIMLTEKGQVLS 124



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 44/178 (24%), Positives = 70/178 (39%), Gaps = 18/178 (10%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDT-QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           WG N++GQL       P  Q I      +  +  + +G  H  A T+ G+V+ WGR ++G
Sbjct: 236 WGRNKHGQLASRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHLVAKTETGKVFTWGRADYG 295

Query: 451 RLG-----------FGDDKS------SHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 323
           +LG              D S       + VP  +  L G    ++SCG  H++ +  D +
Sbjct: 296 QLGRRLEPPEAQKPVEQDSSLAFQGPQNSVPSPLHCLTG--ATEISCGSEHNLAVIRD-K 352

Query: 322 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
             S+            +     P   P+   PP  S       +   V CG  H+LA+
Sbjct: 353 CCSWGWNEHGMCGDGTESNVWTP--TPVQALPPSPS-------RLLLVGCGAGHSLAV 401



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 30/105 (28%), Positives = 53/105 (50%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRL 446
           G N+ GQLG+G T+   +    + L    +  +A G   +  LT++G+V + G    G+L
Sbjct: 74  GLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQL 133

Query: 445 GFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           G        +VP  ++ L  E +V V+ G  H++  T+ G +F +
Sbjct: 134 GVPHGPRKCVVPQAIECLR-EKVVCVAAGLRHALATTATGSVFQW 177



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 36/111 (32%), Positives = 49/111 (44%), Gaps = 8/111 (7%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRS--QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRG--- 461
           G+N +GQLG+    PR    P  +E L    +V +AAG  H+ A T  G V+ WG G   
Sbjct: 126 GSNAFGQLGVPHG-PRKCVVPQAIECLRE-KVVCVAAGLRHALATTATGSVFQWGTGLAS 183

Query: 460 EHGRLGFGDDKSSHMV---PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 317
              RL  G +    +    P +V  L     V    G  HS  LT  G ++
Sbjct: 184 SGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAVAGSDHSASLTDTGELY 234



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 22/70 (31%), Positives = 32/70 (45%), Gaps = 6/70 (8%)
 Frame = -3

Query: 508 SAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC------GGTHS 347
           S  ++    ++AWG   +G+LG G  K    +P Q+      D  Q  C      GG HS
Sbjct: 8   SETVSAAAVLFAWGANSYGQLGLG-HKEDVFLPQQL-----SDFCQAGCIKSVTGGGGHS 61

Query: 346 VVLTSDGRIF 317
            V+T  G +F
Sbjct: 62  AVVTDGGDLF 71

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>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9)
          Length = 984

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 37/108 (34%), Positives = 57/108 (52%), Gaps = 3/108 (2%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRL 446
           G   +GQLG GD     QP  VE L   ++  ++ G   +  +T EG++YA+G   +G +
Sbjct: 399 GTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCM 458

Query: 445 GFGDDKSSH---MVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           G   DK S    + P+Q+       + QVSCG  H VVLT +  ++S+
Sbjct: 459 GV--DKVSGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSW 504



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 32/108 (29%), Positives = 57/108 (52%), Gaps = 2/108 (1%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRS--QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 458
           A+G++ YG +G+         +P+++    +  +  ++ G  H   LT+  EVY+WG GE
Sbjct: 449 AFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGE 508

Query: 457 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
           +GRLG  D +  +  P +V +     IV V CG   + +LT  G++ +
Sbjct: 509 YGRLGL-DSEEDYYTPQRVDVPKALIIVAVQCGCDGTFLLTQSGKVLA 555



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 12/119 (10%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +WG  EYG+LG+   +    P RV+    L +V +  G   +  LT+ G+V A G  E  
Sbjct: 503 SWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFN 562

Query: 451 RLGFG-------DDKSSHMVPLQVQL-----LAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           +LG         + ++ H VP          L+   I  ++ G TH+  +   GR+ ++
Sbjct: 563 KLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTF 621



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 25/103 (24%), Positives = 49/103 (47%), Gaps = 6/103 (5%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +G N+ GQLG+G+ + R     + G L    ++ ++ G   + A T +  ++AWG G +G
Sbjct: 621 FGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNG 680

Query: 451 RLGFGDDKSSHMVPLQVQ-----LLAGEDIVQVSCGGTHSVVL 338
           RL     +  H   +          +   +  +SC G H++++
Sbjct: 681 RLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHTILI 723

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>RCC1_DROME (P25171) Regulator of chromosome condensation (Chromatin-binding|
           protein Bj1)
          Length = 547

 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 39/111 (35%), Positives = 60/111 (54%), Gaps = 6/111 (5%)
 Frame = -3

Query: 625 GNNEYGQLGIG-DTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           GN + GQLG+G D   R +   V G+ +   VDI+AGG H+  LTK G++Y++G  + G 
Sbjct: 48  GNGDVGQLGLGEDILERKRLSPVAGIPDA--VDISAGGMHNLVLTKSGDIYSFGCNDEGA 105

Query: 448 LG-----FGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           LG      G +    ++ L  + L       +S G +HS  L  DGR+F++
Sbjct: 106 LGRDTSEDGSESKPDLIDLPGKALC------ISAGDSHSACLLEDGRVFAW 150



 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 32/98 (32%), Positives = 55/98 (56%), Gaps = 2/98 (2%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQP-RSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           G  EYG+LG+GD +    +P  V+ L+   +V +  G   S A+T +G++Y+WG G + +
Sbjct: 318 GRPEYGRLGLGDVKDVVEKPTIVKKLTE-KIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQ 376

Query: 448 LGFGD-DKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 338
           LG GD D     + +  +   G+ ++  S GG H++ L
Sbjct: 377 LGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFL 414



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 35/115 (30%), Positives = 57/115 (49%), Gaps = 9/115 (7%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVD-------IAAGGWHSAALTKEGEVYA 473
           ++G N+ G LG   ++  S+       S   L+D       I+AG  HSA L ++G V+A
Sbjct: 97  SFGCNDEGALGRDTSEDGSE-------SKPDLIDLPGKALCISAGDSHSACLLEDGRVFA 149

Query: 472 WG--RGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
           WG  R  HG +G   D +       + L+ G     ++ G  H V+LT+ G++F+
Sbjct: 150 WGSFRDSHGNMGLTIDGNKR---TPIDLMEGTVCCSIASGADHLVILTTAGKVFT 201



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 30/73 (41%), Positives = 40/73 (54%)
 Frame = -3

Query: 529 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH 350
           IA G  H+  LT + +    GR E+GRLG GD K     P  V+ L  E IV V CG   
Sbjct: 298 IAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLT-EKIVSVGCGEVC 356

Query: 349 SVVLTSDGRIFSY 311
           S  +T DG+++S+
Sbjct: 357 SYAVTIDGKLYSW 369



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 23/60 (38%), Positives = 34/60 (56%), Gaps = 1/60 (1%)
 Frame = -3

Query: 487 GEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAG-EDIVQVSCGGTHSVVLTSDGRIFSY 311
           G V   G G+ G+LG G+D        ++  +AG  D V +S GG H++VLT  G I+S+
Sbjct: 42  GNVLVCGNGDVGQLGLGEDILERK---RLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSF 98

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>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase
           8) (Nek8)
          Length = 979

 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 34/106 (32%), Positives = 55/106 (51%), Gaps = 1/106 (0%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRL 446
           G   +GQLG GD     QP  VE L   ++  ++ G   +  +T EG++YA+G   +G +
Sbjct: 399 GTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCM 458

Query: 445 GFGDDKSSHMV-PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           G        ++ P+Q+       + QVSCG  H VVLT +  ++S+
Sbjct: 459 GVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSW 504



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 32/108 (29%), Positives = 57/108 (52%), Gaps = 2/108 (1%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRS--QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 458
           A+G++ YG +G+         +P+++    +  +  ++ G  H   LT+  EVY+WG GE
Sbjct: 449 AFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGE 508

Query: 457 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
           +GRLG  D +  +  P +V +     IV V CG   + +LT  G++ +
Sbjct: 509 YGRLGL-DSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLA 555



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 31/119 (26%), Positives = 54/119 (45%), Gaps = 12/119 (10%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +WG  EYG+LG+   +    P +V+    L +V +  G   +  LT+ G+V A G  E  
Sbjct: 503 SWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFN 562

Query: 451 RLGFG-------DDKSSHMVPLQVQL-----LAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           +LG         + ++ H VP          L+   I  ++ G TH+  +   GR+ ++
Sbjct: 563 KLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTF 621



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 25/103 (24%), Positives = 49/103 (47%), Gaps = 6/103 (5%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           +G N+ GQLG+G+ + R     + G L    ++ ++ G   + A T +  ++AWG G +G
Sbjct: 621 FGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNG 680

Query: 451 RLGFGDDKSSHMVPLQVQ-----LLAGEDIVQVSCGGTHSVVL 338
           RL     +  H   +          +   +  +SC G H++++
Sbjct: 681 RLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHTILI 723

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>RCC1_CANAL (P52499) Protein RCC1|
          Length = 464

 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 17/124 (13%)
 Frame = -3

Query: 631 AWGNNEYGQLGI----GDTQPRS---QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYA 473
           AWG N+YGQ  +    G+ +  S   +P  +  LS+  + +IAAG  H+ ALT++G+VYA
Sbjct: 274 AWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELSHKGIKEIAAGEHHTLALTEDGQVYA 333

Query: 472 WGRGEHGRLGFGDDK----------SSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 323
           WGR +   +G   DK           +H     +Q L    I  +  G  HS  +T DG 
Sbjct: 334 WGRYDMKEIGIPKDKLPKSTFKINTGTHGSFSFLQNLFAVKIKTIGVGSHHSFAVTEDGV 393

Query: 322 IFSY 311
           ++++
Sbjct: 394 VYAW 397



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 27/88 (30%), Positives = 48/88 (54%), Gaps = 6/88 (6%)
 Frame = -3

Query: 556 GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRL------GFGDDKSSHMVPLQVQL 395
           GL N+    IA+G +H  A+     VYAWG  ++G+       G  +D S  M P  +  
Sbjct: 249 GLYNIKY--IASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPE 306

Query: 394 LAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           L+ + I +++ G  H++ LT DG+++++
Sbjct: 307 LSHKGIKEIAAGEHHTLALTEDGQVYAW 334



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 35/140 (25%), Positives = 56/140 (40%), Gaps = 34/140 (24%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDT-------QPRSQP-IRVEGLSNLSLVDIAAGGWHSAALTKEGEVYA 473
           WG     +LG+G +       +PR  P +  E L    +VD A GG H+ AL  +  +++
Sbjct: 29  WGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLGGTKIVDFAVGGMHTLALDGKNRIWS 88

Query: 472 WGRGEHGRLG--------------------------FGDDKSSHMVPLQVQLLAGEDIVQ 371
           WG  +   LG                           GD   +   P  V+ L   +IVQ
Sbjct: 89  WGGNDSEVLGRDTCQAKEVLKDIDGKNGNDDDDDDEDGDLNEAESTPALVENLPEGEIVQ 148

Query: 370 VSCGGTHSVVLTSDGRIFSY 311
           ++     S  L S+G ++S+
Sbjct: 149 LAATDNLSAALLSNGDVYSW 168



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 13/109 (11%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIRV-----------EGLSNLSLVDIAAGGWHSAALTKEG 485
           AWG  +  ++GI   +      ++           + L  + +  I  G  HS A+T++G
Sbjct: 333 AWGRYDMKEIGIPKDKLPKSTFKINTGTHGSFSFLQNLFAVKIKTIGVGSHHSFAVTEDG 392

Query: 484 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLA--GEDIVQVSCGGTHSV 344
            VYAWG  E    G G        P ++   A   EDI+ +  GG  SV
Sbjct: 393 VVYAWGFAETYGPGLGPSIDDVEKPTRIVNTATKNEDILLIGAGGQFSV 441



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 30/82 (36%), Positives = 41/82 (50%), Gaps = 4/82 (4%)
 Frame = -3

Query: 625 GNNEYGQLGIGD-TQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWG--RGEH 455
           GN++      GD  +  S P  VE L    +V +AA    SAAL   G+VY+WG  R   
Sbjct: 116 GNDDDDDDEDGDLNEAESTPALVENLPEGEIVQLAATDNLSAALLSNGDVYSWGCFRCNE 175

Query: 454 GRLGF-GDDKSSHMVPLQVQLL 392
           G LGF  D+      PL+++ L
Sbjct: 176 GLLGFLRDEIKLQKTPLKIKEL 197



 Score = 34.7 bits (78), Expect = 0.24
 Identities = 20/65 (30%), Positives = 29/65 (44%), Gaps = 7/65 (10%)
 Frame = -3

Query: 484 EVYAWGRGEHGRLGFGDDKSSHMVP-------LQVQLLAGEDIVQVSCGGTHSVVLTSDG 326
           +V+ WG G    LG G    +  V        L  + L G  IV  + GG H++ L    
Sbjct: 25  DVFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLGGTKIVDFAVGGMHTLALDGKN 84

Query: 325 RIFSY 311
           RI+S+
Sbjct: 85  RIWSW 89

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>MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4641

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 43/132 (32%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
 Frame = -3

Query: 544  LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 365
            L  V ++ G  HS  L + G+VY +G G+HG+LG G D +S   P  VQ L G    QV+
Sbjct: 902  LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPS-TQVT 959

Query: 364  CGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHP-MEVPI--NLPPPKTSTSSEGLW 194
             G  H+ VL  DG++F++            K   G P ++VP     P P  +  S+   
Sbjct: 960  AGSNHTAVLLMDGQVFTF--------GSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGR 1011

Query: 193  QANYVACGGRHT 158
            +A ++   G  T
Sbjct: 1012 KATWIGASGDQT 1023



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 23/62 (37%), Positives = 34/62 (54%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
            +G  ++GQLG GD   R  P  V+ L   S   + AG  H+A L  +G+V+ +G    G+
Sbjct: 926  FGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSNHTAVLLMDGQVFTFGSFSKGQ 984

Query: 448  LG 443
            LG
Sbjct: 985  LG 986



 Score = 33.9 bits (76), Expect = 0.41
 Identities = 21/88 (23%), Positives = 43/88 (48%)
 Frame = -3

Query: 574 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 395
           +P ++  +    +V  A     S+ ++K+GE+Y +G+          D SS +  L+   
Sbjct: 590 KPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKD-----AIYSDSSSLVTDLK--- 641

Query: 394 LAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
             G  + QV+ G  H+ VL  +G ++++
Sbjct: 642 --GHFVTQVAMGKAHTCVLMKNGEVWTF 667

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>RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)|
          Length = 539

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 46/180 (25%), Positives = 76/180 (42%), Gaps = 18/180 (10%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRS-QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           WGN +  QLG    + R  Q +  + L+  +++ + AG +HS A+  +G VYAWG     
Sbjct: 250 WGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISVGAGSYHSFAIDNKGRVYAWGLNITR 309

Query: 451 RLGF--GDDKSSHMV--PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXX 284
           + G    D++   ++  P  V  L G ++  ++ G  H++ L  DGR+ ++         
Sbjct: 310 QCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEHHTLALLEDGRVLAWGRDDR---- 365

Query: 283 XXRKVTTGHPMEVPINLPPP-------------KTSTSSEGLWQANYVACGGRHTLAIVT 143
                   H + +P N  P               T T   GL     V CG  H LA+ +
Sbjct: 366 --------HQLGIPDNALPETVVKDEKGNNYYLSTPTIIPGLTNVIQVVCGTHHNLAVTS 417



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 36/123 (29%), Positives = 61/123 (49%), Gaps = 16/123 (13%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPR-----SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWG 467
           AWG N   Q GI           ++P  V+ L   ++  I  G  H+ AL ++G V AWG
Sbjct: 302 AWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEHHTLALLEDGRVLAWG 361

Query: 466 RGEHGRLGFGD----------DKSSHMVPLQVQLLAG-EDIVQVSCGGTHSVVLTSDGRI 320
           R +  +LG  D          +K ++       ++ G  +++QV CG  H++ +TSDG++
Sbjct: 362 RDDRHQLGIPDNALPETVVKDEKGNNYYLSTPTIIPGLTNVIQVVCGTHHNLAVTSDGKV 421

Query: 319 FSY 311
           +S+
Sbjct: 422 YSW 424



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 33/113 (29%), Positives = 55/113 (48%), Gaps = 16/113 (14%)
 Frame = -3

Query: 631 AWGNNEYGQLGI--------------GDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALT 494
           AWG ++  QLGI              G+    S P  + GL+N+  + +  G  H+ A+T
Sbjct: 359 AWGRDDRHQLGIPDNALPETVVKDEKGNNYYLSTPTIIPGLTNV--IQVVCGTHHNLAVT 416

Query: 493 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV--QVSCGGTHSVV 341
            +G+VY+WG  E+  +G GD+     VP  V+  A +++       GG  S++
Sbjct: 417 SDGKVYSWGSAENYEVGQGDNDEDVAVPTLVRSKAIKEVAIRVAGAGGQFSII 469



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 32/100 (32%), Positives = 50/100 (50%)
 Frame = -3

Query: 610 GQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDD 431
           G LG  D+Q R+       L  +    +A G  H  ALT  G+VY WG G+  +LG    
Sbjct: 206 GVLGYSDSQKRTAEPTQMRLPEIC--QLATGTDHIIALTTTGKVYTWGNGQQFQLGRRML 263

Query: 430 KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           +   +  L  Q LA ++I+ V  G  HS  + + GR++++
Sbjct: 264 ERRRLQGLTPQPLALKNIISVGAGSYHSFAIDNKGRVYAW 303



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 35/125 (28%), Positives = 56/125 (44%), Gaps = 19/125 (15%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQ------PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWG 467
           +G+    +LG+G+ +      PR  PI       + +VD+A GG HSAAL+ +G VY WG
Sbjct: 76  FGSGSMNELGMGEEEMDVVYRPRLNPIL--STDKVGVVDLAVGGMHSAALSHDGRVYTWG 133

Query: 466 RGEHGRLG--FGDDKSSHMVPLQVQLLAGED-----------IVQVSCGGTHSVVLTSDG 326
             +   LG    D K  +   +   LL G             + +V C    +  +T +G
Sbjct: 134 VNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALSHLRVTKVICSDNLTAAITDNG 193

Query: 325 RIFSY 311
             F++
Sbjct: 194 CCFTW 198

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>MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4711

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 41/132 (31%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
 Frame = -3

Query: 544  LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 365
            L  V ++ G  HS  L + G+VY +G G+HG+LG G D +S   P  VQ L G    QV+
Sbjct: 902  LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPS-TQVT 959

Query: 364  CGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHP-MEVPI--NLPPPKTSTSSEGLW 194
                H+ VL  DG++F++            K   G P +++P     P P  +  S+   
Sbjct: 960  ACSNHTAVLLMDGQVFTF--------GSFSKGQLGRPILDIPYWNAKPAPMPNIGSKYGR 1011

Query: 193  QANYVACGGRHT 158
            +A ++   G  T
Sbjct: 1012 KATWIGASGDQT 1023



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 22/62 (35%), Positives = 33/62 (53%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
            +G  ++GQLG GD   R  P  V+ L   S   + A   H+A L  +G+V+ +G    G+
Sbjct: 926  FGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTACSNHTAVLLMDGQVFTFGSFSKGQ 984

Query: 448  LG 443
            LG
Sbjct: 985  LG 986



 Score = 33.5 bits (75), Expect = 0.54
 Identities = 22/88 (25%), Positives = 42/88 (47%)
 Frame = -3

Query: 574 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 395
           +P ++  +    +V  A     S+ ++K+GE+Y +G+          D SS      V  
Sbjct: 590 KPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKD-----AIYSDSSS-----LVSD 639

Query: 394 LAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           L G  + QV+ G  H+ VL  +G ++++
Sbjct: 640 LKGHFVTQVAMGKAHTCVLMKNGEVWTF 667

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>HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-) (Protein|
            pam/highwire/rpm-1)
          Length = 5233

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 29/62 (46%), Positives = 41/62 (66%)
 Frame = -3

Query: 628  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
            +G+N+YGQLG GD QP S P+RV+    +S   +AAG  H+  LT +G VY +G  + G+
Sbjct: 990  FGSNQYGQLGSGDLQPVSGPVRVQVPGAIS--QVAAGSNHTVLLTSKGMVYTFGNYQKGQ 1047

Query: 448  LG 443
            LG
Sbjct: 1048 LG 1049



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 34/94 (36%), Positives = 55/94 (58%), Gaps = 3/94 (3%)
 Frame = -3

Query: 583  PRSQPIRVEGL---SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 413
            PR  P+  + L   S+  +V +A G  H+  LT  GEVY +G  ++G+LG GD +     
Sbjct: 950  PRVAPLAPQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSG- 1008

Query: 412  PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            P++VQ+     I QV+ G  H+V+LTS G ++++
Sbjct: 1009 PVRVQVPGA--ISQVAAGSNHTVLLTSKGMVYTF 1040

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>WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 16 protein|
           homolog
          Length = 461

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 34/105 (32%), Positives = 55/105 (52%), Gaps = 1/105 (0%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           WG +  GQ G+G     S P ++ G L+ +++V +A  G    AL+ +G V+ WG  E+ 
Sbjct: 253 WGAD--GQTGLGHYNITSTPSKLGGDLAGVTVVQVATYGDCCLALSADGGVFGWGNSEYL 310

Query: 451 RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 317
           +L    D +   VP  +       + QV+CGGT   VL ++G +F
Sbjct: 311 QLASVTDSTQVNVPRCLPFSGVGKVKQVACGGTGCAVLNAEGHVF 355



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 46/157 (29%), Positives = 70/157 (44%), Gaps = 4/157 (2%)
 Frame = -3

Query: 625 GNNEYGQLG--IGDTQPRSQPIRVEGLSNLS--LVDIAAGGWHSAALTKEGEVYAWGRGE 458
           GNN +GQ G  + + +  S+  +V  + +    +V +  G  HS  LT +GEVY+ G G 
Sbjct: 196 GNNSHGQCGRKVVEDEVYSESHKVHRMQDFDGQVVQVVCGQDHSLFLTDKGEVYSCGWGA 255

Query: 457 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXX 278
            G+ G G    +         LAG  +VQV+  G   + L++DG +F +           
Sbjct: 256 DGQTGLGHYNITSTPSKLGGDLAGVTVVQVATYGDCCLALSADGGVFGW---GNSEYLQL 312

Query: 277 RKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGG 167
             VT    + VP  LP         G+ +   VACGG
Sbjct: 313 ASVTDSTQVNVPRCLP-------FSGVGKVKQVACGG 342



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 36/117 (30%), Positives = 49/117 (41%), Gaps = 13/117 (11%)
 Frame = -3

Query: 628 WGNNEYGQLG--IGDTQ---PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGR 464
           WGN+EY QL      TQ   PR  P    G     +  +A GG   A L  EG V+ WG 
Sbjct: 304 WGNSEYLQLASVTDSTQVNVPRCLPFSGVG----KVKQVACGGTGCAVLNAEGHVFVWG- 358

Query: 463 GEHGRLGFGDDKSSHMVPLQV--------QLLAGEDIVQVSCGGTHSVVLTSDGRIF 317
             +G LG G       +P  +        +      + Q+ CG +H   LT+ G +F
Sbjct: 359 --YGILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQIRCGLSHFAALTNKGELF 413



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 37/106 (34%), Positives = 50/106 (47%), Gaps = 9/106 (8%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQ-----PRSQPIRVEGLSNLS----LVDIAAGGWHSAALTKEGEVY 476
           WG   YG LG G        P   P  + GL+  +    +  I  G  H AALT +GE++
Sbjct: 357 WG---YGILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQIRCGLSHFAALTNKGELF 413

Query: 475 AWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 338
            WG+   G LG G  +  +  P +V  + GE  V V+CG  H V L
Sbjct: 414 VWGKNIRGCLGIGRLEDQYF-PWRV-TMPGEP-VDVACGVDHMVTL 456



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 27/98 (27%), Positives = 42/98 (42%), Gaps = 12/98 (12%)
 Frame = -3

Query: 571 PIRVEGLSNLSLVDIAAGGWHSAALTKE-GEVYAWGRGEHGRLGFGDDKSSHM------- 416
           P R+E    +S      G    ++ TK+  +V+  G  +  +LGF   +           
Sbjct: 97  PYRLELDHKISSAACGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 156

Query: 415 ----VPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 314
               VPL +       ++QVSCG  HS+VLT    +FS
Sbjct: 157 EPSPVPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFS 194

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>RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-)|
            (Pam/highwire/rpm-1 protein) (Regulator of presynaptic
            morphology protein 1) (Synapse defective protein 3)
          Length = 3766

 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 28/89 (31%), Positives = 51/89 (57%)
 Frame = -3

Query: 577  SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 398
            S+ I  +G  ++ +  ++ G +H+  L  +  V+ +G   HG+LG GD  S +  P QV 
Sbjct: 756  SRVILSQGPHDVKVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKN-TPQQVI 814

Query: 397  LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            L +   IVQV+ G  H+++  +DG +F++
Sbjct: 815  LPSDTVIVQVAAGSNHTILRANDGSVFTF 843



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 22/61 (36%), Positives = 37/61 (60%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           +G+N +GQLG+GDT  ++ P +V   S+  +V +AAG  H+     +G V+ +G    G+
Sbjct: 791 FGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAAGSNHTILRANDGSVFTFGAFGKGQ 850

Query: 448 L 446
           L
Sbjct: 851 L 851

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>WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 16 protein|
          Length = 464

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 45/157 (28%), Positives = 70/157 (44%), Gaps = 4/157 (2%)
 Frame = -3

Query: 625 GNNEYGQLG--IGDTQPRSQPIRVEGLSNLS--LVDIAAGGWHSAALTKEGEVYAWGRGE 458
           GNN YGQ G  + + +  S+  RV  + +    +V +A G  HS  LT +GEVY+ G G 
Sbjct: 199 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 258

Query: 457 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXX 278
            G+ G G    +         LAG +++QV+  G   + +++DG +F +           
Sbjct: 259 DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW---GNSEYLQL 315

Query: 277 RKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGG 167
             VT    + VP  L          G+ +    ACGG
Sbjct: 316 ASVTDSTQVNVPRCL-------HFSGVGKVRQAACGG 345



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 30/105 (28%), Positives = 53/105 (50%), Gaps = 1/105 (0%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHG 452
           WG +  GQ G+G     S P ++ G L+ ++++ +A  G    A++ +G ++ WG  E+ 
Sbjct: 256 WGAD--GQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYL 313

Query: 451 RLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 317
           +L    D +   VP  +       + Q +CGGT   VL  +G +F
Sbjct: 314 QLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVF 358



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 38/113 (33%), Positives = 49/113 (43%), Gaps = 9/113 (7%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA-GGWHSAALTKEGEVYAWGRGEHG 452
           WGN+EY QL       +    R    S +  V  AA GG   A L  EG V+ WG   +G
Sbjct: 307 WGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YG 363

Query: 451 RLGFGDDKSSHMVPLQVQ-----LLAGEDIVQVS---CGGTHSVVLTSDGRIF 317
            LG G +     VP  +      L      +QVS   CG +H   LT+ G +F
Sbjct: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELF 416



 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 37/106 (34%), Positives = 50/106 (47%), Gaps = 9/106 (8%)
 Frame = -3

Query: 628 WGNNEYGQLGIG-----DTQPRSQPIRVEGLSN----LSLVDIAAGGWHSAALTKEGEVY 476
           WG   YG LG G        P   P  + GL+     + +  I  G  H AALT +GE++
Sbjct: 360 WG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELF 416

Query: 475 AWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 338
            WG+   G LG G  +  +  P +V  + GE  V V+CG  H V L
Sbjct: 417 VWGKNIRGCLGIGRLEDQYF-PWRV-TMPGEP-VDVACGVDHMVTL 459

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>RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 protein)|
           (Pheromone response pathway component SRM1)
          Length = 482

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/112 (30%), Positives = 59/112 (52%), Gaps = 6/112 (5%)
 Frame = -3

Query: 631 AWGNNEYGQLG---IGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRG 461
           AWGN +  QLG   +   + ++   R  GL ++    IA+G  H  ALTK+ ++ +WG  
Sbjct: 244 AWGNGQQNQLGRKVMERFRLKTLDPRPFGLRHVKY--IASGENHCFALTKDNKLVSWGLN 301

Query: 460 EHGRLGFGDDKSSHMVPLQVQLLAGED---IVQVSCGGTHSVVLTSDGRIFS 314
           + G+ G  +D     +  + + LA  D   I  ++ G  HS++L+ DG ++S
Sbjct: 302 QFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLILSQDGDLYS 353



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 34/122 (27%), Positives = 58/122 (47%), Gaps = 15/122 (12%)
 Frame = -3

Query: 631 AWGNNEYGQLGIG----DTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGR 464
           +WG N++GQ G+     D    ++P R+    N+ +  IAAG  HS  L+++G++Y+ GR
Sbjct: 297 SWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLILSQDGDLYSCGR 356

Query: 463 GEHGRLGFGDDK-----------SSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 317
            +   +G   D             +  VPL  +L        V+ G  HSV +  +G  +
Sbjct: 357 LDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNGIAY 416

Query: 316 SY 311
           S+
Sbjct: 417 SW 418



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 25/64 (39%), Positives = 36/64 (56%), Gaps = 2/64 (3%)
 Frame = -3

Query: 529 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGED--IVQVSCGG 356
           +AAG  HS A+ + G  Y+WG GE   +G G  +    VP +++  A +D  I+ V CGG
Sbjct: 399 VAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEVPTRIKNTATQDHNIILVGCGG 458

Query: 355 THSV 344
             SV
Sbjct: 459 QFSV 462



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 30/79 (37%), Positives = 42/79 (53%), Gaps = 3/79 (3%)
 Frame = -3

Query: 538 LVDIAAGGWHSAALTKEGEVYAWG--RGEHGRLGFGDDK-SSHMVPLQVQLLAGEDIVQV 368
           +V +AA    S AL   GEVYAWG  R   G LGF  DK      P +V   +  +IVQ+
Sbjct: 167 VVQLAATDNMSCALFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYNIVQL 226

Query: 367 SCGGTHSVVLTSDGRIFSY 311
           + G  H + L  +G +F++
Sbjct: 227 APGKDHILFLDEEGMVFAW 245



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 33/112 (29%), Positives = 52/112 (46%), Gaps = 5/112 (4%)
 Frame = -3

Query: 631 AWGN---NEYGQLGIGDTQPRSQ--PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWG 467
           AWG    NE G LG    + + Q  P +V   S  ++V +A G  H   L +EG V+AWG
Sbjct: 188 AWGTFRCNE-GILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAWG 246

Query: 466 RGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
            G+  +LG    +   +  L  +      +  ++ G  H   LT D ++ S+
Sbjct: 247 NGQQNQLGRKVMERFRLKTLDPRPFGLRHVKYIASGENHCFALTKDNKLVSW 298



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 32/141 (22%), Positives = 53/141 (37%), Gaps = 35/141 (24%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDT-------QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAW 470
           WG     +LG+G         +PR  P          ++  A GG H+ AL +E  V++W
Sbjct: 51  WGTGSMCELGLGPLAKNKEVKRPRLNPFLPR--DEAKIISFAVGGMHTLALDEESNVWSW 108

Query: 469 GRGEHGRLG-----------------FGDDKSSHMVPLQ-----------VQLLAGEDIV 374
           G  + G LG                   DD+   +  L+             L  G  +V
Sbjct: 109 GCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLNELESTPAKIPRESFPPLAEGHKVV 168

Query: 373 QVSCGGTHSVVLTSDGRIFSY 311
           Q++     S  L S+G ++++
Sbjct: 169 QLAATDNMSCALFSNGEVYAW 189

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>ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)|
          Length = 333

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 3/108 (2%)
 Frame = -3

Query: 631 AWGNNEYGQLGIGDTQPRSQPIR-VEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 455
           A+G+N   QLG+G  +    P R V G     +  IA GG HS  LT +G +   G    
Sbjct: 6   AFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDNRR 65

Query: 454 GRLGFGD--DKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 317
           G L       +     P++V       +V V+CG   +V++ +DGR++
Sbjct: 66  GELDSAQALRQVHDWRPVEVP----APVVDVACGWDTTVIVDADGRVW 109



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 29/111 (26%), Positives = 45/111 (40%)
 Frame = -3

Query: 481 VYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXX 302
           VYA+G     +LG G D+        V    G  + +++CGG HSV+LT+DG +      
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDN 63

Query: 301 XXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 149
                   + +   H    P+ +P P              VACG   T+ +
Sbjct: 64  RRGELDSAQALRQVHDWR-PVEVPAPVVD-----------VACGWDTTVIV 102

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>RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell cycle|
           regulatory protein) (RCC1 homolog)
          Length = 569

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 29/89 (32%), Positives = 39/89 (43%), Gaps = 6/89 (6%)
 Frame = -3

Query: 559 EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGF------GDDKSSHMVPLQVQ 398
           EGL  L  V   AGG HSA LT EGEVY  G  E G +        G       V  +  
Sbjct: 183 EGLKPLQAV---AGGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAKVKFEED 239

Query: 397 LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 311
           +     IV ++ G + +  LT  G + ++
Sbjct: 240 IEKEGKIVMLAAGASFTAALTDQGSVIAW 268



 Score = 36.2 bits (82), Expect = 0.083
 Identities = 23/79 (29%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
 Frame = -3

Query: 538 LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV---PLQVQLLAGEDIVQV 368
           +V +AAG   +AALT +G V AWG   +           H +   P+ +   A   IV++
Sbjct: 246 IVMLAAGASFTAALTDQGSVIAWGNLRNSNGNVDVHPLLHKMQEAPVVIVHQAKRKIVKI 305

Query: 367 SCGGTHSVVLTSDGRIFSY 311
           + G  H V+L   G + ++
Sbjct: 306 AAGENHLVMLDEKGCLLTF 324



 Score = 32.7 bits (73), Expect = 0.92
 Identities = 30/109 (27%), Positives = 47/109 (43%), Gaps = 11/109 (10%)
 Frame = -3

Query: 631 AWGNNEYGQLGIG------DTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAW 470
           A G N    LG+G      D Q        E   +  +V ++A    S A +++G  YAW
Sbjct: 457 AMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFDSKIVGVSAKLATSIAWSEDGTAYAW 516

Query: 469 GRGEHGRLGFG-DDKSSHMVPLQVQL----LAGEDIVQVSCGGTHSVVL 338
           G    G+LG G  D+   MV    ++    L G  I+  S    H++++
Sbjct: 517 GFDTTGQLGLGLKDEDEKMVSKPEEISSAHLDGYSIIGASISDQHTLII 565

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>FBX24_HUMAN (O75426) F-box only protein 24|
          Length = 580

 Score = 39.3 bits (90), Expect = 0.010
 Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 4/81 (4%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEG----EVYAWGRGE 458
           GNN YGQLG GD   R +P +V  L     + +  G  HS  L++      E+   G G 
Sbjct: 382 GNNRYGQLGTGDKMDRGEPTQVCYLQR--PITLWCGLNHSLVLSQSSEFSKELLGCGCGA 439

Query: 457 HGRLGFGDDKSSHMVPLQVQL 395
            GRL      S+  V LQV++
Sbjct: 440 GGRLPGWPKGSASFVKLQVKV 460

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>FBX24_MOUSE (Q9D417) F-box only protein 24|
          Length = 589

 Score = 37.7 bits (86), Expect = 0.029
 Identities = 27/81 (33%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
 Frame = -3

Query: 625 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEG----EVYAWGRGE 458
           GNN YGQLG GD   R +P +V  L     + +  G  HS  L++      E+   G G 
Sbjct: 392 GNNRYGQLGTGDKMDRGEPTQVHYLQR--PIALWCGLNHSLVLSQTSDFSKELLGCGCGA 449

Query: 457 HGRLGFGDDKSSHMVPLQVQL 395
            GRL      S+  V L +++
Sbjct: 450 GGRLPGWPKGSASFVKLHIKV 470

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>YB9W_YEAST (P38352) F-box protein YBR280C|
          Length = 637

 Score = 35.4 bits (80), Expect = 0.14
 Identities = 15/39 (38%), Positives = 26/39 (66%), Gaps = 2/39 (5%)
 Frame = -3

Query: 547 NLSLVDIAAGGWHSAALTKEGEVYAWG--RGEHGRLGFG 437
           N +++ +A+G +H+ ALT+ G +Y+WG    + G LG G
Sbjct: 545 NENVISVASGDYHTVALTERGHLYSWGIESQDCGCLGLG 583

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>UNC5B_HUMAN (Q8IZJ1) Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5|
           homolog 2) (p53-regulated receptor for death and life
           protein 1)
          Length = 945

 Score = 33.9 bits (76), Expect = 0.41
 Identities = 18/54 (33%), Positives = 25/54 (46%)
 Frame = +1

Query: 304 PSRKRISGRHWLAQLNGSLHMIPEQYPLQLEAEPVVAPCGCSYHPQSRASHVLL 465
           P    +S R W+ QL    H    +  + L+ E +  PC C   P  RA H+LL
Sbjct: 623 PHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPCYCQLEP--RACHILL 674

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>TKT_SCHPO (Q9URM2) Probable transketolase (EC 2.2.1.1) (TK)|
          Length = 685

 Score = 32.3 bits (72), Expect = 1.2
 Identities = 22/70 (31%), Positives = 31/70 (44%)
 Frame = -3

Query: 628 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 449
           +G  E+G  GI +      PI   G + L+ V  AAG    AAL     +Y      H  
Sbjct: 418 YGIREHGMAGIMNGLAVYGPIIPYGGTFLNFVSYAAGAVRMAALNNSRVIYV---ATHDS 474

Query: 448 LGFGDDKSSH 419
           +G G+D  +H
Sbjct: 475 IGLGEDGPTH 484

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>PHLD_MOUSE (O70362) Phosphatidylinositol-glycan-specific phospholipase D 1|
           precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein
           phospholipase D) (Glycosyl-phosphatidylinositol-specific
           phospholipase D)
          Length = 837

 Score = 29.6 bits (65), Expect = 7.8
 Identities = 12/24 (50%), Positives = 14/24 (58%)
 Frame = +1

Query: 331 HWLAQLNGSLHMIPEQYPLQLEAE 402
           HW   LN S+H I E YPL  E +
Sbjct: 88  HWTPFLNASIHYIRENYPLPWEKD 111


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,502,002
Number of Sequences: 219361
Number of extensions: 2236135
Number of successful extensions: 5932
Number of sequences better than 10.0: 52
Number of HSP's better than 10.0 without gapping: 5322
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5714
length of database: 80,573,946
effective HSP length: 107
effective length of database: 57,102,319
effective search space used: 5881538857
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

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full-length cDNA and EST

Clone Information

BLAST Search Result