ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags9l03 |
|---|---|
| Clone Library Name | barley_pub |
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 82.4 bits (202), Expect = 1e-15 Identities = 40/83 (48%), Positives = 52/83 (62%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 EEWT DL +L +G FA GA ++YRG Y VA+K++ P LEQQF EV Sbjct: 77 EEWTADLSQLFIGNKFASGAHSRIYRGIYKQRAVAVKMVRIPTHKEETRAKLEQQFKSEV 136 Query: 503 RMLAELRHPNIVKFVGACRKPIV 571 +L+ L HPNIV+F+ AC+KP V Sbjct: 137 ALLSRLFHPNIVQFIAACKKPPV 159
>KSR1_MOUSE (Q61097) Kinase suppressor of ras-1 (Kinase suppressor of ras)| (mKSR1) (Hb protein) Length = 873 Score = 62.0 bits (149), Expect = 1e-09 Identities = 36/104 (34%), Positives = 57/104 (54%) Frame = +2 Query: 290 TRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQA 469 +R ++T +EW I ++ +G P QG +G+++RG ++G +VAI+LLE + Sbjct: 543 SRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG-EVAIRLLEMDGHNQDHL 601 Query: 470 QLLEQQFVQEVRMLAELRHPNIVKFVGACRKPIVLVHCHRVCKG 601 +L F +EV + RH N+V F+GAC P L CKG Sbjct: 602 KL----FKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKG 641
>KSR1_HUMAN (Q8IVT5) Kinase suppressor of ras-1 (Kinase suppressor of ras)| Length = 921 Score = 62.0 bits (149), Expect = 1e-09 Identities = 36/104 (34%), Positives = 57/104 (54%) Frame = +2 Query: 290 TRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQA 469 +R ++T +EW I ++ +G P QG +G+++RG ++G +VAI+LLE + Sbjct: 591 SRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG-EVAIRLLEMDGHNQDHL 649 Query: 470 QLLEQQFVQEVRMLAELRHPNIVKFVGACRKPIVLVHCHRVCKG 601 +L F +EV + RH N+V F+GAC P L CKG Sbjct: 650 KL----FKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKG 689
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 61.2 bits (147), Expect = 2e-09 Identities = 32/86 (37%), Positives = 50/86 (58%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLL 478 P L E+ ID +L G +G FG++ RG + DVAIK++ R + + ++ Sbjct: 1272 PPPQLPVRSEYEIDFNELEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSSLVM 1331 Query: 479 EQQFVQEVRMLAELRHPNIVKFVGAC 556 F EV +L++LRHPN+V+F+GAC Sbjct: 1332 ---FQNEVGILSKLRHPNVVQFLGAC 1354
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 60.5 bits (145), Expect = 4e-09 Identities = 32/100 (32%), Positives = 57/100 (57%), Gaps = 3/100 (3%) Frame = +2 Query: 326 EWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVR 505 +W ID +L +G G +G++Y+ + G +VA+KL+ ++ +E+ F +EV+ Sbjct: 778 DWEIDFSELEIGETLGTGGYGEVYKSIWKGTEVAVKLISSKHV----SKDMERSFFEEVK 833 Query: 506 MLAELRHPNIVKFVGACRK-PIVLVHCHRVCKG--WDLLG 616 ++ LRHPN+V F+ A K P + + + G +DLLG Sbjct: 834 IMTSLRHPNVVLFMAASTKSPNMCIVMEFMSLGSLYDLLG 873 Score = 58.5 bits (140), Expect = 2e-08 Identities = 50/202 (24%), Positives = 93/202 (46%), Gaps = 26/202 (12%) Frame = +2 Query: 50 GSTMSIDSLNSMQTSMHGGSIM-------SVDNSSVGSTDSRTGMLNHPSHRGPVAVVSY 208 GST++I + T HGG I+ V+N T + + ++PS + + + + Sbjct: 1242 GSTVNITG--KITTLTHGGQIIVSENLYQKVNNDFTFITVGKIDIPDYPS-KMTLYEIKF 1298 Query: 209 SVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKDYE------------------EWT 334 + + F G +DD + D+ + + + D + W Sbjct: 1299 EILKNRFFGGITYVNYNDDTDSGTADDSNYDSGKIIDIDYMADIDKEDSFLTSANMCRWI 1358 Query: 335 IDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLA 514 I+ ++ +G G++G ++ G + G+DVA+K + + + QLLE F E+ L+ Sbjct: 1359 INYDEISIGKQIGLGSYGIVFNGKWKGVDVAVKKFVKQKLS--ETQLLE--FRAEMAFLS 1414 Query: 515 ELRHPNIVKFVGAC-RKPIVLV 577 EL+H NIV F+GAC +KP + + Sbjct: 1415 ELKHSNIVTFIGACIKKPNICI 1436
>KSR2_HUMAN (Q6VAB6) Kinase suppressor of ras-2 (hKSR2)| Length = 829 Score = 58.9 bits (141), Expect = 1e-08 Identities = 40/120 (33%), Positives = 61/120 (50%), Gaps = 2/120 (1%) Frame = +2 Query: 266 ALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLL-- 439 +L A R ++T +EW I +L +G +G FG++Y G ++G +VAI+L+ Sbjct: 517 SLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDI 575 Query: 440 ERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGACRKPIVLVHCHRVCKGWDLLGI 619 ER D +A F +EV + RH N+V F+GAC P L +CKG L + Sbjct: 576 ERDNEDQLKA------FKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSV 629
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 54.3 bits (129), Expect = 3e-07 Identities = 30/81 (37%), Positives = 46/81 (56%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W I G++ +G G+FG +Y+G ++G DVA+K+L P Q Q F EV Sbjct: 10 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQL----QAFKNEV 64 Query: 503 RMLAELRHPNIVKFVGACRKP 565 +L + RH NI+ F+G KP Sbjct: 65 GVLRKTRHVNILLFMGYSTKP 85
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 54.3 bits (129), Expect = 3e-07 Identities = 30/81 (37%), Positives = 46/81 (56%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W I G++ +G G+FG +Y+G ++G DVA+K+L P Q Q F EV Sbjct: 448 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQL----QAFKNEV 502 Query: 503 RMLAELRHPNIVKFVGACRKP 565 +L + RH NI+ F+G KP Sbjct: 503 GVLRKTRHVNILLFMGYSTKP 523
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 54.3 bits (129), Expect = 3e-07 Identities = 30/81 (37%), Positives = 46/81 (56%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W I G++ +G G+FG +Y+G ++G DVA+K+L P Q Q F EV Sbjct: 488 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQL----QAFKNEV 542 Query: 503 RMLAELRHPNIVKFVGACRKP 565 +L + RH NI+ F+G KP Sbjct: 543 GVLRKTRHVNILLFMGYSTKP 563
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 54.3 bits (129), Expect = 3e-07 Identities = 30/81 (37%), Positives = 46/81 (56%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W I G++ +G G+FG +Y+G ++G DVA+K+L P Q Q F EV Sbjct: 488 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQL----QAFKNEV 542 Query: 503 RMLAELRHPNIVKFVGACRKP 565 +L + RH NI+ F+G KP Sbjct: 543 GVLRKTRHVNILLFMGYSTKP 563
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 54.3 bits (129), Expect = 3e-07 Identities = 30/81 (37%), Positives = 46/81 (56%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W I G++ +G G+FG +Y+G ++G DVA+K+L P Q Q F EV Sbjct: 74 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQL----QAFKNEV 128 Query: 503 RMLAELRHPNIVKFVGACRKP 565 +L + RH NI+ F+G KP Sbjct: 129 GVLRKTRHVNILLFMGYSTKP 149
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 54.3 bits (129), Expect = 3e-07 Identities = 30/81 (37%), Positives = 46/81 (56%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W I G++ +G G+FG +Y+G ++G DVA+K+L P Q Q F EV Sbjct: 58 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQL----QAFKNEV 112 Query: 503 RMLAELRHPNIVKFVGACRKP 565 +L + RH NI+ F+G KP Sbjct: 113 GVLRKTRHVNILLFMGYSTKP 133
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 53.9 bits (128), Expect = 4e-07 Identities = 43/159 (27%), Positives = 78/159 (49%), Gaps = 7/159 (4%) Frame = +2 Query: 122 DNSSVGSTDSRTGMLNHPSHRGPVAVV---SYSVGNSIFRPGRVSHALSDDALA---QAL 283 + S+V +T S N H P + + S+ S+ +L+D A + + Sbjct: 25 EKSNVSNTSSIISASNLNRHITPNSHMRPRGRSISESLIMSPINKESLNDIQRAIESEKI 84 Query: 284 MDTRFPT-ETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADP 460 T+F +++ E+ ID+ + +GAF +++ G + G+ VAIK L + D Sbjct: 85 KKTKFEELKSILGEREYIIDINDIQFIQKVGEGAFSEVWEGWWKGIHVAIKKL-KIIGDE 143 Query: 461 PQAQLLEQQFVQEVRMLAELRHPNIVKFVGACRKPIVLV 577 Q +++F++EV+ L + H NIV F+GAC KP ++ Sbjct: 144 EQ---FKERFIREVQNLKKGNHQNIVMFIGACYKPACII 179
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 53.5 bits (127), Expect = 5e-07 Identities = 35/109 (32%), Positives = 57/109 (52%) Frame = +2 Query: 251 ALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAI 430 A S + + A P++ L ++EE ID ++ + +GAFG + + + DVAI Sbjct: 6 AASSSSSSSASEMIEAPSQVL-NFEE--IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAI 62 Query: 431 KLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGACRKPIVLV 577 K +E ++ + F+ E+R L+ + HPNIVK GAC P+ LV Sbjct: 63 KQIE--------SESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLV 103
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 53.1 bits (126), Expect = 6e-07 Identities = 32/93 (34%), Positives = 52/93 (55%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLL 478 P++ L ++EE ID ++ + +GAFG + + + DVAIK +E ++ Sbjct: 22 PSQVL-NFEE--IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE--------SESE 70 Query: 479 EQQFVQEVRMLAELRHPNIVKFVGACRKPIVLV 577 + F+ E+R L+ + HPNIVK GAC P+ LV Sbjct: 71 RKAFIVELRQLSRVNHPNIVKLYGACLNPVCLV 103
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 52.8 bits (125), Expect = 8e-07 Identities = 27/64 (42%), Positives = 36/64 (56%), Gaps = 1/64 (1%) Frame = +2 Query: 377 GAFGKLYRGTYNGMDVAIKLLER-PEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGA 553 G FGK+YR + G +VA+K PE DP + +Q QE R+ L+HPNI+ GA Sbjct: 107 GGFGKVYRALWRGEEVAVKAARLDPEKDPA---VTAEQVCQEARLFGALQHPNIIALRGA 163 Query: 554 CRKP 565 C P Sbjct: 164 CLNP 167
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 51.6 bits (122), Expect = 2e-06 Identities = 39/121 (32%), Positives = 62/121 (51%), Gaps = 9/121 (7%) Frame = +2 Query: 242 VSHALSD-DALAQALMD----TRFP-TETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRG 403 VSH + D D LAQ L P T L +EW ID + + QG FG+++ G Sbjct: 24 VSHYMMDADGLAQRLSRPCSRANIPITSGLSYKDEWEIDRTTIQLQRKLGQGNFGEVWAG 83 Query: 404 TYNGMD-VAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGACR--KPIVL 574 +NG VA+K L +P+ + + FVQE +++ ++ HPN+++ C +PI + Sbjct: 84 VWNGTTAVAVKTL-KPDT------MEVKDFVQEAQVMKKIHHPNLLQLYAVCTIGEPIYI 136 Query: 575 V 577 V Sbjct: 137 V 137
>FES_HUMAN (P07332) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 822 Score = 51.2 bits (121), Expect = 2e-06 Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W ++ L +G +G FG+++ G + + + E PP L+ +F+QE Sbjct: 552 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPD---LKAKFLQEA 608 Query: 503 RMLAELRHPNIVKFVGAC--RKPIVLV 577 R+L + HPNIV+ +G C ++PI +V Sbjct: 609 RILKQYSHPNIVRLIGVCTQKQPIYIV 635
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 51.2 bits (121), Expect = 2e-06 Identities = 27/83 (32%), Positives = 47/83 (56%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQ 496 D ++ I L++ G+FG ++R ++G DVA+K+L + + +F++ Sbjct: 540 DGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVN----EFLR 595 Query: 497 EVRMLAELRHPNIVKFVGACRKP 565 EV ++ LRHPNIV F+GA +P Sbjct: 596 EVAIMKRLRHPNIVLFMGAVTQP 618
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 51.2 bits (121), Expect = 2e-06 Identities = 29/88 (32%), Positives = 52/88 (59%), Gaps = 3/88 (3%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 ++W ++ + +G +G FG++Y+GT VA+K + D PQ L+ +F+QE Sbjct: 55 KKWVLNHEDVSLGELLGKGNFGEVYKGTLKDKTPVAVKTCKE---DLPQE--LKIKFLQE 109 Query: 500 VRMLAELRHPNIVKFVGAC--RKPIVLV 577 ++L + HPNIVK +G C R+P+ ++ Sbjct: 110 AKILKQYDHPNIVKLIGVCTQRQPVYII 137
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 820 Score = 50.8 bits (120), Expect = 3e-06 Identities = 26/87 (29%), Positives = 47/87 (54%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W + L +G +G FG+++ G + + + E PP L+ +F+QE Sbjct: 550 DKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPD---LKAKFLQEA 606 Query: 503 RMLAELRHPNIVKFVGAC--RKPIVLV 577 R+L + HPNIV+ +G C ++PI +V Sbjct: 607 RILKQYNHPNIVRLIGVCTQKQPIYIV 633
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 50.8 bits (120), Expect = 3e-06 Identities = 25/87 (28%), Positives = 49/87 (56%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W ++ + +G +G FG+++ G + + + E PP+ L+ +F+QE Sbjct: 603 DKWVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPE---LKAKFLQEA 659 Query: 503 RMLAELRHPNIVKFVGAC--RKPIVLV 577 R+L + HPNIV+ +G C ++PI +V Sbjct: 660 RILKQCNHPNIVRLIGVCTQKQPIYIV 686
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 50.8 bits (120), Expect = 3e-06 Identities = 25/87 (28%), Positives = 49/87 (56%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W ++ + +G +G FG+++ G + + + E PP+ L+ +F+QE Sbjct: 263 DKWVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPE---LKAKFLQEA 319 Query: 503 RMLAELRHPNIVKFVGAC--RKPIVLV 577 R+L + HPNIV+ +G C ++PI +V Sbjct: 320 RILKQYNHPNIVRLIGVCTQKQPIYIV 346
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 50.4 bits (119), Expect = 4e-06 Identities = 29/96 (30%), Positives = 53/96 (55%), Gaps = 3/96 (3%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQL 475 PT L +++W I +L + G FG + RG + G +D A+K+++ + + Sbjct: 510 PTAGLS-HDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMK-------EGTM 561 Query: 476 LEQQFVQEVRMLAELRHPNIVKFVGACRK--PIVLV 577 E F++E +++ +L+HPN+V+ G C K PI +V Sbjct: 562 SEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIV 597
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 50.1 bits (118), Expect = 5e-06 Identities = 29/88 (32%), Positives = 51/88 (57%), Gaps = 3/88 (3%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGM-DVAIKLLERPEADPPQAQLLEQQFVQE 499 ++W + + +G +G FG++Y+GT VA+K + D PQ L+ +F+QE Sbjct: 554 KKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKE---DLPQE--LKIKFLQE 608 Query: 500 VRMLAELRHPNIVKFVGAC--RKPIVLV 577 ++L + HPNIVK +G C R+P+ ++ Sbjct: 609 AKILKQYDHPNIVKLIGVCTQRQPVYII 636
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 49.7 bits (117), Expect = 7e-06 Identities = 29/78 (37%), Positives = 45/78 (57%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W I+ ++ + G+FG +Y+G ++G DVA+K+L+ DP QL Q F EV + Sbjct: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILK--VVDPTPEQL--QAFRNEVAV 396 Query: 509 LAELRHPNIVKFVGACRK 562 L + RH NI+ F+G K Sbjct: 397 LRKTRHVNILLFMGYMTK 414
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 49.7 bits (117), Expect = 7e-06 Identities = 29/78 (37%), Positives = 45/78 (57%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W I+ ++ + G+FG +Y+G ++G DVA+K+L+ DP QL Q F EV + Sbjct: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILK--VVDPTPEQL--QAFRNEVAV 396 Query: 509 LAELRHPNIVKFVGACRK 562 L + RH NI+ F+G K Sbjct: 397 LRKTRHVNILLFMGYMTK 414
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC| 2.7.10.2) (C-FES) Length = 820 Score = 49.3 bits (116), Expect = 9e-06 Identities = 24/87 (27%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W ++ L +G +G FG+++ G + + + E PP ++ +F+QE Sbjct: 550 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPD---IKAKFLQEA 606 Query: 503 RMLAELRHPNIVKFVGAC--RKPIVLV 577 ++L + HPNIV+ +G C ++PI +V Sbjct: 607 KILKQYSHPNIVRLIGVCTQKQPIYIV 633
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 49.3 bits (116), Expect = 9e-06 Identities = 25/61 (40%), Positives = 36/61 (59%), Gaps = 1/61 (1%) Frame = +2 Query: 377 GAFGKLYRGTYNGMDVAIKLLERPEADPPQ-AQLLEQQFVQEVRMLAELRHPNIVKFVGA 553 G FG++YR T+ G +VA+K + DP Q A + +E R+ A LRHPNI++ G Sbjct: 133 GGFGQVYRATWQGQEVAVKAARQ---DPEQDAAAAAESVRREARLFAMLRHPNIIELRGV 189 Query: 554 C 556 C Sbjct: 190 C 190
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 49.3 bits (116), Expect = 9e-06 Identities = 24/87 (27%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W ++ L +G +G FG+++ G + + + E PP ++ +F+QE Sbjct: 207 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPD---IKAKFLQEA 263 Query: 503 RMLAELRHPNIVKFVGAC--RKPIVLV 577 ++L + HPNIV+ +G C ++PI +V Sbjct: 264 KILKQYSHPNIVRLIGVCTQKQPIYIV 290
>FES_FSVGA (P00542) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 609 Score = 49.3 bits (116), Expect = 9e-06 Identities = 24/87 (27%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 ++W ++ L +G +G FG+++ G + + + E PP ++ +F+QE Sbjct: 339 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPD---IKAKFLQEA 395 Query: 503 RMLAELRHPNIVKFVGAC--RKPIVLV 577 ++L + HPNIV+ +G C ++PI +V Sbjct: 396 KILKQYSHPNIVRLIGVCTQKQPIYIV 422
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 48.9 bits (115), Expect = 1e-05 Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 3/102 (2%) Frame = +2 Query: 281 LMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEAD 457 LM + P YE+W ID +L G FG ++ G + + VAIK + Sbjct: 248 LMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAIN----- 302 Query: 458 PPQAQLLEQQFVQEVRMLAELRHPNIVKFVGAC--RKPIVLV 577 + + E+ F++E +++ +L H +V+ G C RKP+ +V Sbjct: 303 --EGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIV 342
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 48.9 bits (115), Expect = 1e-05 Identities = 27/78 (34%), Positives = 44/78 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W I+ ++ + G+FG +Y+G ++G DVA+K+L+ + P Q Q F EV + Sbjct: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQF----QAFRNEVAV 396 Query: 509 LAELRHPNIVKFVGACRK 562 L + RH NI+ F+G K Sbjct: 397 LRKTRHVNILLFMGYMTK 414
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 48.9 bits (115), Expect = 1e-05 Identities = 27/78 (34%), Positives = 44/78 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W I+ ++ + G+FG +Y+G ++G DVA+K+L+ + P Q Q F EV + Sbjct: 342 WEIEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQF----QAFRNEVAV 396 Query: 509 LAELRHPNIVKFVGACRK 562 L + RH NI+ F+G K Sbjct: 397 LRKTRHVNILLFMGYMTK 414
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 48.9 bits (115), Expect = 1e-05 Identities = 30/85 (35%), Positives = 43/85 (50%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 E W I ++ +G G+FG +YR ++G VA+K L P Q Q F EV Sbjct: 420 ENWNILAEEILIGPRIGSGSFGTVYRAHWHG-PVAVKTLNVKTPSPAQLQA----FKNEV 474 Query: 503 RMLAELRHPNIVKFVGACRKPIVLV 577 ML + RH NI+ F+G KP + + Sbjct: 475 AMLKKTRHCNILLFMGCVSKPSLAI 499
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 48.5 bits (114), Expect = 2e-05 Identities = 28/78 (35%), Positives = 45/78 (57%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W ++ ++ + G+FG +Y+G ++G DVA+K+L+ DP QL Q F EV + Sbjct: 17 WKMEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILK--VVDPTPEQL--QAFRNEVAV 71 Query: 509 LAELRHPNIVKFVGACRK 562 L + RH NI+ F+G K Sbjct: 72 LRKTRHVNILLFMGYMTK 89
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 48.5 bits (114), Expect = 2e-05 Identities = 27/78 (34%), Positives = 44/78 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W I+ ++ + G+FG +Y+G ++G DVA+K+L+ + P Q Q F EV + Sbjct: 75 WEIEASEVLLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQF----QAFRNEVAV 129 Query: 509 LAELRHPNIVKFVGACRK 562 L + RH NI+ F+G K Sbjct: 130 LRKTRHVNILLFMGYMTK 147
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 47.8 bits (112), Expect = 3e-05 Identities = 29/94 (30%), Positives = 48/94 (51%), Gaps = 1/94 (1%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + L QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 256 DAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 308 Query: 500 VRMLAELRHPNIVKFVGACRKPIVLVHCHRVCKG 601 +++ +LRH +V+ + + + + KG Sbjct: 309 AQVMKKLRHEKLVQLYAVVSEEPIYIVTEYISKG 342
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 47.4 bits (111), Expect = 4e-05 Identities = 27/78 (34%), Positives = 43/78 (55%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W I ++ + G+FG +Y+G ++G DVA+K+L+ + P Q Q F EV + Sbjct: 333 WEIIASEVMLSSRIGSGSFGTVYKGKWHG-DVAVKILKVTDPTPEQLQA----FRNEVAV 387 Query: 509 LAELRHPNIVKFVGACRK 562 L + RH NI+ F+G K Sbjct: 388 LRKTRHVNILLFMGYMTK 405
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 47.0 bits (110), Expect = 5e-05 Identities = 25/91 (27%), Positives = 44/91 (48%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W +DL L +G +G FG + +G Y G VA+K + + + Q F+ E + Sbjct: 187 WLLDLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI--------KCDVTAQAFLDETAV 238 Query: 509 LAELRHPNIVKFVGACRKPIVLVHCHRVCKG 601 + +L+H N+V+ +G + + V KG Sbjct: 239 MTKLQHRNLVRLLGVILHHGLYIVMEHVSKG 269
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 47.0 bits (110), Expect = 5e-05 Identities = 25/91 (27%), Positives = 44/91 (48%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W +DL L +G +G FG + +G Y G VA+K + + + Q F+ E + Sbjct: 226 WLLDLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI--------KCDVTAQAFLDETAV 277 Query: 509 LAELRHPNIVKFVGACRKPIVLVHCHRVCKG 601 + +L+H N+V+ +G + + V KG Sbjct: 278 MTKLQHRNLVRLLGVILHHGLYIVMEHVSKG 308
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 47.0 bits (110), Expect = 5e-05 Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + L QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 256 DAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 308 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 309 AQVMKKLRHEKLVQLYAVVSEEPIYIV 335
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 47.0 bits (110), Expect = 5e-05 Identities = 26/65 (40%), Positives = 36/65 (55%) Frame = +2 Query: 362 LPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVK 541 L +G FG +YR A+K L+ EAD + +++Q F+ EV L+ RHPNIV Sbjct: 216 LRIGEGGFGCVYRAVMRNTTYAVKRLKE-EADL-EWTMVKQSFLTEVEQLSRFRHPNIVD 273 Query: 542 FVGAC 556 F G C Sbjct: 274 FAGYC 278
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 47.0 bits (110), Expect = 5e-05 Identities = 34/130 (26%), Positives = 57/130 (43%), Gaps = 3/130 (2%) Frame = +2 Query: 197 VVSYSVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQ 376 ++ Y NS R+ H +S A + P W + ++ + Sbjct: 349 LIHYHQHNSAGMITRLRHPVSTKA-------NKVPVSVALGSGIWELKREEITLLKELGN 401 Query: 377 GAFGKLYRGTYNGM-DVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGA 553 G FG + G + G DVA+K+++ + + E +F QE + + +L HP +VKF G Sbjct: 402 GQFGVVQLGQWKGQYDVAVKMIK-------EGAMSEDEFFQEAQTMMKLSHPKLVKFYGV 454 Query: 554 CRK--PIVLV 577 C K PI +V Sbjct: 455 CSKKYPIYIV 464
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 47.0 bits (110), Expect = 5e-05 Identities = 28/96 (29%), Positives = 47/96 (48%), Gaps = 3/96 (3%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGM-DVAIKLLERPEADPPQAQL 475 PT YE+W I+ +L G FG + G + VAIK + + + Sbjct: 353 PTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR-------EGAM 405 Query: 476 LEQQFVQEVRMLAELRHPNIVKFVGAC--RKPIVLV 577 E+ F++E +++ +L HP +V+ G C +KPI +V Sbjct: 406 CEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIV 441
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 46.6 bits (109), Expect = 6e-05 Identities = 26/88 (29%), Positives = 46/88 (52%), Gaps = 3/88 (3%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGM-DVAIKLLERPEADPPQAQLLEQQFVQE 499 EEW I+ ++ + G FG+++ G +NG VA+K L+ + ++F+QE Sbjct: 231 EEWEIEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLK-------PGTMSVEEFLQE 283 Query: 500 VRMLAELRHPNIVKFVGACRK--PIVLV 577 ++ LRHP +++ C K PI +V Sbjct: 284 ASIMKRLRHPKLIQLYAVCTKEEPIYIV 311
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 46.6 bits (109), Expect = 6e-05 Identities = 27/88 (30%), Positives = 48/88 (54%), Gaps = 3/88 (3%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGM-DVAIKLLERPEADPPQAQLLEQQFVQE 499 EEW I+ ++ + G FG+++ G +NG VA+K L+ P +E+ F++E Sbjct: 231 EEWEIEKKQIKLLRGLGAGQFGEVWEGLWNGTTSVAVKTLK------PGTMSIEE-FLEE 283 Query: 500 VRMLAELRHPNIVKFVGACRK--PIVLV 577 ++ +LRHP +++ C K PI +V Sbjct: 284 ASIMKQLRHPKLIQLYAVCTKEEPIYIV 311
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 46.6 bits (109), Expect = 6e-05 Identities = 34/130 (26%), Positives = 57/130 (43%), Gaps = 3/130 (2%) Frame = +2 Query: 197 VVSYSVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQ 376 ++ Y NS R+ H +S A + P W + ++ + Sbjct: 373 LIHYHQHNSAGMITRLRHPVSTKA-------NKVPDSVSLGNGIWELKREEITLLKELGS 425 Query: 377 GAFGKLYRGTYNGM-DVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGA 553 G FG + G + G DVA+K+++ + + E +F QE + + +L HP +VKF G Sbjct: 426 GQFGVVQLGKWKGQYDVAVKMIK-------EGSMSEDEFFQEAQTMMKLSHPKLVKFYGV 478 Query: 554 CRK--PIVLV 577 C K PI +V Sbjct: 479 CSKEYPIYIV 488
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 46.6 bits (109), Expect = 6e-05 Identities = 28/76 (36%), Positives = 41/76 (53%) Frame = +2 Query: 335 IDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLA 514 ID +L + G FGK+YR + G +VA+K R + D +Q +E QE ++ A Sbjct: 139 IDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAA-RHDPDEDISQTIEN-VRQEAKLFA 196 Query: 515 ELRHPNIVKFVGACRK 562 L+HPNI+ G C K Sbjct: 197 MLKHPNIIALRGVCLK 212
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 46.6 bits (109), Expect = 6e-05 Identities = 27/102 (26%), Positives = 51/102 (50%), Gaps = 3/102 (2%) Frame = +2 Query: 281 LMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEAD 457 L+ + P + YE+W ID +L G FG ++ G + + VAIK + Sbjct: 248 LLGSCLPATSGFSYEKWEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAIN----- 302 Query: 458 PPQAQLLEQQFVQEVRMLAELRHPNIVKFVGAC--RKPIVLV 577 + + E+ F++E +++ +L H +V+ G C +KP+ +V Sbjct: 303 --EGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIV 342
>RYK2_DROME (Q9V422) Tyrosine-protein kinase Dnt precursor (EC 2.7.10.1)| (Protein doughnut) Length = 584 Score = 45.8 bits (107), Expect = 1e-04 Identities = 43/159 (27%), Positives = 66/159 (41%), Gaps = 1/159 (0%) Frame = +2 Query: 77 NSMQTSMHGGSIMSVDNSSVGSTDSRTGMLNHPSHRGPVAVVSYSVGNSIFRPGRVSHAL 256 N Q HGG M T S + HP + + +Y SI P H Sbjct: 238 NKRQHHQHGGQPMR--------TSSFQRLNTHPPCQSSMGSAAYMTP-SIIAP---IHGS 285 Query: 257 SDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIK 433 S ++ + P E + E T++ ++ + +G FG++YRGTYN DV +K Sbjct: 286 SLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQDVLVK 345 Query: 434 LLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 + + A Q LL +QE +L HP I+ +G Sbjct: 346 TVAQ-HASQMQVLLL----LQEGMLLYGASHPGILSVLG 379
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 45.8 bits (107), Expect = 1e-04 Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 3/96 (3%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGM-DVAIKLLERPEADPPQAQL 475 PT Y++W I+ +L G FG + G + VAIK + + + Sbjct: 352 PTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR-------EGAM 404 Query: 476 LEQQFVQEVRMLAELRHPNIVKFVGAC--RKPIVLV 577 E+ F++E +++ +L HP +V+ G C +KPI +V Sbjct: 405 CEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIV 440
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 45.8 bits (107), Expect = 1e-04 Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 257 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 309 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 310 AQVMKKLRHEKLVRLYAVVSEEPIYIV 336
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 257 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 309 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 310 AQVMKKLRHKKLVQLYAVVSEEPIYIV 336
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 257 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 309 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 310 AQVMKKLRHEKLVQLYAVVSEEPIYIV 336
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 257 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 309 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 310 AQVMKKLRHEKLVQLYAVVSEEPIYIV 336
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 257 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 309 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 310 AQVMKKLRHEKLVQLYAVVSEEPIYIV 336
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 45.4 bits (106), Expect = 1e-04 Identities = 25/79 (31%), Positives = 45/79 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W + ++ + G+FG ++RG ++G DVA+K+L+ + QAQ F E+++ Sbjct: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVAQPTAEQAQA----FKNEMQV 357 Query: 509 LAELRHPNIVKFVGACRKP 565 L + RH NI+ F+G +P Sbjct: 358 LRKTRHVNILLFMGFMTRP 376
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 45.4 bits (106), Expect = 1e-04 Identities = 25/79 (31%), Positives = 45/79 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W + ++ + G+FG ++RG ++G DVA+K+L+ + QAQ F E+++ Sbjct: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVSQPTAEQAQA----FKNEMQV 357 Query: 509 LAELRHPNIVKFVGACRKP 565 L + RH NI+ F+G +P Sbjct: 358 LRKTRHVNILLFMGFMTRP 376
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 45.4 bits (106), Expect = 1e-04 Identities = 24/91 (26%), Positives = 44/91 (48%), Gaps = 3/91 (3%) Frame = +2 Query: 314 KDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQF 490 K ++W ID + + G FG+++ G +N VA+K L+ DP F Sbjct: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDP-------NDF 274 Query: 491 VQEVRMLAELRHPNIVKFVGAC--RKPIVLV 577 ++E +++ LRHP +++ C PI ++ Sbjct: 275 LREAQIMKNLRHPKLIQLYAVCTLEDPIYII 305
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 45.4 bits (106), Expect = 1e-04 Identities = 20/84 (23%), Positives = 46/84 (54%), Gaps = 2/84 (2%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYN--GMDVAIKLLERPEADPPQAQLLEQQF 490 +Y++W ++ + M G +G++Y G + + VA+K L+ + ++F Sbjct: 231 NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV-------EEF 283 Query: 491 VQEVRMLAELRHPNIVKFVGACRK 562 ++E ++ E++HPN+V+ +G C + Sbjct: 284 LKEAAVMKEIKHPNLVQLLGVCTR 307
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 260 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 312 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 313 AQVMKKLRHEKLVQLYAVVSEEPIYIV 339
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 260 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 312 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 313 AQVMKKLRHEKLVQLYAVVSEEPIYIV 339
>RYK1_DROME (Q27324) Tyrosine-protein kinase Drl precursor (EC 2.7.10.1)| (Protein derailed) Length = 610 Score = 45.4 bits (106), Expect = 1e-04 Identities = 26/84 (30%), Positives = 40/84 (47%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLL 478 P E + +E T+ ++ + +G FG++YRGTYN + A Q LL Sbjct: 326 PEEFNRRLQELTVQKCRVRLSCLVQEGNFGRIYRGTYNDCQEVLVKTVAQHASQLQVNLL 385 Query: 479 EQQFVQEVRMLAELRHPNIVKFVG 550 +QE ML E HPN++ +G Sbjct: 386 ----LQESMMLYEASHPNVLSVLG 405
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 45.4 bits (106), Expect = 1e-04 Identities = 25/79 (31%), Positives = 45/79 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W + ++ + G+FG ++RG ++G DVA+K+L+ + QAQ F E+++ Sbjct: 301 WEVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVAQPTAEQAQA----FKNEMQV 355 Query: 509 LAELRHPNIVKFVGACRKP 565 L + RH NI+ F+G +P Sbjct: 356 LRKTRHVNILLFMGFMTRP 374
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 45.4 bits (106), Expect = 1e-04 Identities = 25/79 (31%), Positives = 45/79 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W + ++ + G+FG ++RG ++G DVA+K+L+ + QAQ F E+++ Sbjct: 301 WEVPPSEVQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVAQPTAEQAQA----FKNEMQV 355 Query: 509 LAELRHPNIVKFVGACRKP 565 L + RH NI+ F+G +P Sbjct: 356 LRKTRHVNILLFMGFMTRP 374
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 257 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 309 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 310 AQVMKKLRHEKLVQLYAVVSEEPIYIV 336
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 45.4 bits (106), Expect = 1e-04 Identities = 20/84 (23%), Positives = 46/84 (54%), Gaps = 2/84 (2%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYN--GMDVAIKLLERPEADPPQAQLLEQQF 490 +Y++W ++ + M G +G++Y G + + VA+K L+ + ++F Sbjct: 117 NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV-------EEF 169 Query: 491 VQEVRMLAELRHPNIVKFVGACRK 562 ++E ++ E++HPN+V+ +G C + Sbjct: 170 LKEAAVMKEIKHPNLVQLLGVCTR 193
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 265 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 317 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 318 AQVMKKLRHEKLVQLYAVVSEEPIYIV 344
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 45.4 bits (106), Expect = 1e-04 Identities = 20/84 (23%), Positives = 46/84 (54%), Gaps = 2/84 (2%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYN--GMDVAIKLLERPEADPPQAQLLEQQF 490 +Y++W ++ + M G +G++Y G + + VA+K L+ + ++F Sbjct: 180 NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV-------EEF 232 Query: 491 VQEVRMLAELRHPNIVKFVGACRK 562 ++E ++ E++HPN+V+ +G C + Sbjct: 233 LKEAAVMKEIKHPNLVQLLGVCTR 256
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 45.4 bits (106), Expect = 1e-04 Identities = 20/84 (23%), Positives = 46/84 (54%), Gaps = 2/84 (2%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYN--GMDVAIKLLERPEADPPQAQLLEQQF 490 +Y++W ++ + M G +G++Y G + + VA+K L+ + ++F Sbjct: 231 NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV-------EEF 283 Query: 491 VQEVRMLAELRHPNIVKFVGACRK 562 ++E ++ E++HPN+V+ +G C + Sbjct: 284 LKEAAVMKEIKHPNLVQLLGVCTR 307
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 257 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 309 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 310 AQVMKKLRHEKLVQLYAVVSEEPIYIV 336
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 45.4 bits (106), Expect = 1e-04 Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 7/95 (7%) Frame = +2 Query: 287 DTRFPT-------ETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLER 445 DTRF + +++E I +G MG +G FG +Y+G N VA+K L Sbjct: 162 DTRFHSFSFYELKNVTNNFDERPISVGGNKMG----EGGFGVVYKGYVNNTTVAVKKLAA 217 Query: 446 PEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 + L+QQF QE++++A+ +H N+V+ +G Sbjct: 218 MVDITTEE--LKQQFDQEIKVMAKCQHENLVELLG 250
>KRAF1_CAEEL (Q07292) Raf homolog serine/threonine-protein kinase (EC 2.7.11.1)| (Abnormal cell lineage protein 45) Length = 813 Score = 45.1 bits (105), Expect = 2e-04 Identities = 29/86 (33%), Positives = 46/86 (53%) Frame = +2 Query: 320 YEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQE 499 +E+W I + + G+FG +YRG + G VAIK L DP +Q+ F E Sbjct: 471 HEDWEILPNEFIIQYKVGSGSFGTVYRGEFFGT-VAIKKLN--VVDPTPSQMAA--FKNE 525 Query: 500 VRMLAELRHPNIVKFVGACRKPIVLV 577 V +L + RH N++ F+G R+P + + Sbjct: 526 VAVLKKTRHLNVLLFMGWVREPEIAI 551
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 45.1 bits (105), Expect = 2e-04 Identities = 23/91 (25%), Positives = 44/91 (48%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W ++L L +G +G FG + +G Y G VA+K + + + Q F+ E + Sbjct: 228 WLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI--------KCDVTAQAFLDETAV 279 Query: 509 LAELRHPNIVKFVGACRKPIVLVHCHRVCKG 601 + +++H N+V+ +G + + V KG Sbjct: 280 MTKMQHENLVRLLGVILHQGLYIVMEHVSKG 310
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 45.1 bits (105), Expect = 2e-04 Identities = 26/74 (35%), Positives = 40/74 (54%) Frame = +2 Query: 335 IDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLA 514 + L ++ G+FGK+Y+G VAIK R A+ ++ F +EV +L Sbjct: 457 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIK---RYRANTYCSKSDVDMFCREVSILC 513 Query: 515 ELRHPNIVKFVGAC 556 +L HP +V+FVGAC Sbjct: 514 QLNHPCVVQFVGAC 527
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 45.1 bits (105), Expect = 2e-04 Identities = 26/74 (35%), Positives = 40/74 (54%) Frame = +2 Query: 335 IDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLA 514 + L ++ G+FGK+Y+G VAIK R A+ ++ F +EV +L Sbjct: 456 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIK---RYRANTYCSKSDVDMFCREVSILC 512 Query: 515 ELRHPNIVKFVGAC 556 +L HP +V+FVGAC Sbjct: 513 QLNHPCVVQFVGAC 526
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 44.7 bits (104), Expect = 2e-04 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 3/89 (3%) Frame = +2 Query: 320 YEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQ 496 Y +W ID +L G FG ++ G + D VAIK + + + E+ F++ Sbjct: 353 YGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIR-------EGAMSEEDFIE 405 Query: 497 EVRMLAELRHPNIVKFVGAC--RKPIVLV 577 E ++ +L HP +V+ G C + PI LV Sbjct: 406 EAEVMMKLSHPKLVQLYGVCLEQAPICLV 434
>FGFR4_HUMAN (P22455) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) (CD334 antigen) Length = 802 Score = 44.7 bits (104), Expect = 2e-04 Identities = 38/134 (28%), Positives = 60/134 (44%), Gaps = 12/134 (8%) Frame = +2 Query: 218 NSIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLY 397 +S+ R R+S S AL L+ P + L W +L +G P +G FG++ Sbjct: 430 SSLVRGVRLSS--SGPALLAGLVSLDLPLDPL-----WEFPRDRLVLGKPLGEGCFGQVV 482 Query: 398 RGTYNGMD---------VAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 R GMD VA+K+L+ +D A L+ + V ++ RH NI+ +G Sbjct: 483 RAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG----RHKNIINLLG 538 Query: 551 ACRKP---IVLVHC 583 C + V+V C Sbjct: 539 VCTQEGPLYVIVEC 552
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 44.7 bits (104), Expect = 2e-04 Identities = 22/59 (37%), Positives = 33/59 (55%) Frame = +2 Query: 374 QGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 QG FG +YRG + +DVAIK++ + Q + QQ E++ L +RH NI+ G Sbjct: 221 QGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYG 279
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 44.7 bits (104), Expect = 2e-04 Identities = 25/74 (33%), Positives = 40/74 (54%) Frame = +2 Query: 335 IDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLA 514 + L ++ G+FGK+Y+G VAIK R A+ ++ F +EV +L Sbjct: 457 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIK---RYRANTYCSKSDVDMFCREVSILC 513 Query: 515 ELRHPNIVKFVGAC 556 +L HP +++FVGAC Sbjct: 514 QLNHPCVIQFVGAC 527
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 254 DAWEIPRESLRLEVKLGQGYFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 306 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 307 AQVMKKLRHEKLVQLYAMVSEEPIYIV 333
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 257 DAWEIPRESLRLEAKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEA------FLQE 309 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 310 AQVMKKLRHEKLVQLYAVVSEEPIYIV 336
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 44.7 bits (104), Expect = 2e-04 Identities = 25/74 (33%), Positives = 40/74 (54%) Frame = +2 Query: 335 IDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLA 514 + L ++ G+FGK+Y+G VAIK R A+ ++ F +EV +L Sbjct: 559 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIK---RYRANTYCSKSDVDMFCREVSILC 615 Query: 515 ELRHPNIVKFVGAC 556 +L HP +++FVGAC Sbjct: 616 QLNHPCVIQFVGAC 629
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 44.3 bits (103), Expect = 3e-04 Identities = 24/85 (28%), Positives = 41/85 (48%) Frame = +2 Query: 302 TETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLE 481 + + D + I+ +L + G F K++RG Y+G +VAIK+ + D Q + Sbjct: 126 SSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGED--DMQRMR 183 Query: 482 QQFVQEVRMLAELRHPNIVKFVGAC 556 +QE ++ L+H NI G C Sbjct: 184 DNVLQEAKLFWALKHENIAALRGVC 208
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 44.3 bits (103), Expect = 3e-04 Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 267 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTL-KPGTMMPEA------FLQE 319 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V + +PI +V Sbjct: 320 AQIMKKLRHDKLVPLYAVVSEEPIYIV 346
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 44.3 bits (103), Expect = 3e-04 Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 265 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTL-KPGTMMPEA------FLQE 317 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V + +PI +V Sbjct: 318 AQIMKKLRHDKLVPLYAVVSEEPIYIV 344
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 44.3 bits (103), Expect = 3e-04 Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 265 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTL-KPGTMMPEA------FLQE 317 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V + +PI +V Sbjct: 318 AQIMKKLRHDKLVPLYAVVSEEPIYIV 344
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 43.9 bits (102), Expect = 4e-04 Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 4/89 (4%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG--MDVAIKLLERPEADPPQAQLLEQQFVQ 496 E W + + + +G FG +Y+ +DVA+K D + ++F+Q Sbjct: 1054 ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQK-----RKFLQ 1108 Query: 497 EVRMLAELRHPNIVKFVGAC--RKPIVLV 577 E R+L + HPNIVK +G C ++PI++V Sbjct: 1109 EGRILKQYDHPNIVKLIGICVQKQPIMIV 1137
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 43.9 bits (102), Expect = 4e-04 Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F+QE Sbjct: 261 DAWEIPRESLRLDVKLGQGCFGEVWIGTWNGTTKVAIKTL-KPGTMMPEA------FLQE 313 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V + +PI +V Sbjct: 314 AQIMKKLRHDKLVPLYAVVSEEPIYIV 340
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 43.9 bits (102), Expect = 4e-04 Identities = 24/65 (36%), Positives = 33/65 (50%) Frame = +2 Query: 362 LPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVK 541 L +G FG +YR A+K L+ E + ++Q F+ EV L+ RHPNIV Sbjct: 216 LKIGEGGFGCVYRAVMRNTVYAVKRLK--ENADLEWTAVKQSFLTEVEQLSRFRHPNIVD 273 Query: 542 FVGAC 556 F G C Sbjct: 274 FAGYC 278
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 43.5 bits (101), Expect = 5e-04 Identities = 28/87 (32%), Positives = 47/87 (54%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L +P P+A F++E Sbjct: 268 DAWEIPRESLRLDVRLGQGCFGEVWMGTWNGTTKVAIKTL-KPGTMSPEA------FLEE 320 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V + +PI +V Sbjct: 321 AQIMKKLRHDKLVPLYAVVSEEPIYIV 347
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 43.5 bits (101), Expect = 5e-04 Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L+ ++ + F+QE Sbjct: 263 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLK-------LGTMMPEAFLQE 315 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V + +PI +V Sbjct: 316 AQIMKKLRHDKLVPLYAVVSEEPIYIV 342
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/109 (26%), Positives = 50/109 (45%), Gaps = 6/109 (5%) Frame = +2 Query: 242 VSHALSD-DALAQALMDTRFPTETLKDYEE-----WTIDLGKLHMGLPFAQGAFGKLYRG 403 V H SD D L L+ + T+ +E W +++ +L + +G FG + G Sbjct: 153 VEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG 212 Query: 404 TYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 Y G VA+K ++ Q F+ E ++ +LRH N+V+ +G Sbjct: 213 DYRGNKVAVKCIKN--------DATAQAFLAEASVMTQLRHSNLVQLLG 253
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 43.5 bits (101), Expect = 5e-04 Identities = 22/63 (34%), Positives = 32/63 (50%) Frame = +2 Query: 374 QGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGA 553 +G FGK+Y G NG VA+K+L A ++F EV +L + H N+ VG Sbjct: 582 KGGFGKVYHGVINGEQVAVKVLSEESAQG------YKEFRAEVDLLMRVHHTNLTSLVGY 635 Query: 554 CRK 562 C + Sbjct: 636 CNE 638
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 43.5 bits (101), Expect = 5e-04 Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + + QG FG+++ GT+NG VAIK L+ ++ + F+QE Sbjct: 258 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLK-------LGTMMPEAFLQE 310 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V + +PI +V Sbjct: 311 AQIMKKLRHDKLVPLYAVVSEEPIYIV 337
>ROS_HUMAN (P08922) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2347 Score = 43.1 bits (100), Expect = 7e-04 Identities = 24/78 (30%), Positives = 41/78 (52%), Gaps = 8/78 (10%) Frame = +2 Query: 347 KLHMGLPFAQGAFGKLYRGTY--------NGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 KL + L GAFG++Y GT + VA+K L++ D + + F++E Sbjct: 1944 KLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIE-----FLKEA 1998 Query: 503 RMLAELRHPNIVKFVGAC 556 ++++ HPNI+K +G C Sbjct: 1999 HLMSKFNHPNILKQLGVC 2016
>KIT_FELCA (Q28889) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 978 Score = 43.1 bits (100), Expect = 7e-04 Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 9/95 (9%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEAD 457 PT+ D++ W +L G GAFGK+ T G M VA+K+L+ Sbjct: 574 PTQLPYDHK-WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK----- 627 Query: 458 PPQAQLLEQQ-FVQEVRMLAEL-RHPNIVKFVGAC 556 P A L E++ + E+++L+ L H NIV +GAC Sbjct: 628 -PSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 661
>KIT_CAPHI (Q28317) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 978 Score = 43.1 bits (100), Expect = 7e-04 Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 9/95 (9%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEAD 457 PT+ D++ W +L G GAFGK+ T G M VA+K+L+ Sbjct: 574 PTQLPYDHK-WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK----- 627 Query: 458 PPQAQLLEQQ-FVQEVRMLAEL-RHPNIVKFVGAC 556 P A L E++ + E+++L+ L H NIV +GAC Sbjct: 628 -PSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 661
>KIT_BOVIN (P43481) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 977 Score = 43.1 bits (100), Expect = 7e-04 Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 9/95 (9%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEAD 457 PT+ D++ W +L G GAFGK+ T G M VA+K+L+ Sbjct: 574 PTQLPYDHK-WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK----- 627 Query: 458 PPQAQLLEQQ-FVQEVRMLAEL-RHPNIVKFVGAC 556 P A L E++ + E+++L+ L H NIV +GAC Sbjct: 628 -PSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 661
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 43.1 bits (100), Expect = 7e-04 Identities = 23/61 (37%), Positives = 33/61 (54%), Gaps = 1/61 (1%) Frame = +2 Query: 377 GAFGKLYRGTYNGMDVAIKLLER-PEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGA 553 G FGK+YRG++ G VA+K + P+ D + + QE R+ A L HPNI+ Sbjct: 126 GGFGKVYRGSWRGELVAVKAARQDPDED---ISVTAESVRQEARLFAMLAHPNIIALKAV 182 Query: 554 C 556 C Sbjct: 183 C 183
>MOS_XENLA (P12965) Serine/threonine-protein kinase mos (EC 2.7.11.1)| (pp39-mos) Length = 359 Score = 43.1 bits (100), Expect = 7e-04 Identities = 26/74 (35%), Positives = 41/74 (55%) Frame = +2 Query: 332 TIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRML 511 +ID ++ + P G FG +YR TY G VA+K ++R + ++ Q F E+ Sbjct: 57 SIDWEQVLLLEPLGSGGFGSVYRATYRGETVALKKVKRSTKNSLASR---QSFWAELN-A 112 Query: 512 AELRHPNIVKFVGA 553 A LRHP++V+ V A Sbjct: 113 ARLRHPHVVRVVAA 126
>KIT_MOUSE (P05532) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 975 Score = 43.1 bits (100), Expect = 7e-04 Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 9/95 (9%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEAD 457 PT+ D++ W +L G GAFGK+ T G M VA+K+L+ Sbjct: 572 PTQLPYDHK-WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK----- 625 Query: 458 PPQAQLLEQQ-FVQEVRMLAEL-RHPNIVKFVGAC 556 P A L E++ + E+++L+ L H NIV +GAC Sbjct: 626 -PSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 659
>KIT_CANFA (O97799) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 975 Score = 43.1 bits (100), Expect = 7e-04 Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 9/95 (9%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEAD 457 PT+ D++ W +L G GAFGK+ T G M VA+K+L+ Sbjct: 572 PTQLPYDHK-WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK----- 625 Query: 458 PPQAQLLEQQ-FVQEVRMLAEL-RHPNIVKFVGAC 556 P A L E++ + E+++L+ L H NIV +GAC Sbjct: 626 -PSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 659
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 43.1 bits (100), Expect = 7e-04 Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 3/89 (3%) Frame = +2 Query: 320 YEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQ 496 Y +W I +L G FG ++ G + D VAIK ++ + + E+ F++ Sbjct: 358 YGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQ-------EGAMSEEDFIE 410 Query: 497 EVRMLAELRHPNIVKFVGAC--RKPIVLV 577 E ++ +L HP +V+ G C + PI LV Sbjct: 411 EAEVMMKLSHPKLVQLYGVCLEQAPICLV 439
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 43.1 bits (100), Expect = 7e-04 Identities = 25/87 (28%), Positives = 46/87 (52%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQFVQE 499 + W + L + QG F +++RGT+NG VAIK L+ P + F++E Sbjct: 258 DAWEVARDSLFLEQKLGQGCFAEVWRGTWNGNTKVAIKTLKPGTMSP-------ESFLEE 310 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +L+H +V+ + R+PI +V Sbjct: 311 AQIMKKLKHDKLVQLYAVVSRRPIYIV 337
>KIT_HUMAN (P10721) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen) Length = 976 Score = 43.1 bits (100), Expect = 7e-04 Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 9/95 (9%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEAD 457 PT+ D++ W +L G GAFGK+ T G M VA+K+L+ Sbjct: 573 PTQLPYDHK-WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK----- 626 Query: 458 PPQAQLLEQQ-FVQEVRMLAEL-RHPNIVKFVGAC 556 P A L E++ + E+++L+ L H NIV +GAC Sbjct: 627 -PSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 660
>KIT_FSVHZ (P04048) Tyrosine-protein kinase transforming protein kit (EC| 2.7.10.1) Length = 370 Score = 43.1 bits (100), Expect = 7e-04 Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 9/95 (9%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEAD 457 PT+ D++ W +L G GAFGK+ T G M VA+K+L+ Sbjct: 11 PTQLPYDHK-WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK----- 64 Query: 458 PPQAQLLEQQ-FVQEVRMLAEL-RHPNIVKFVGAC 556 P A L E++ + E+++L+ L H NIV +GAC Sbjct: 65 -PSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 98
>ROS_AVISU (P00529) Tyrosine-protein kinase transforming protein ros (EC| 2.7.10.1) Length = 402 Score = 42.7 bits (99), Expect = 9e-04 Identities = 38/157 (24%), Positives = 74/157 (47%), Gaps = 10/157 (6%) Frame = +2 Query: 173 PSHRGPVAVVSYSVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKL 352 P+ G + +V + R + L++ A + + ++ E+L + ++L KL Sbjct: 44 PASTGQIVLVKEDKELAQLRGMAETVGLANACYAVSTLPSQAEIESLPAFPRDKLNLHKL 103 Query: 353 HMGLPFAQGAFGKLYRGTYNGM--------DVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 GAFG++Y GT + VA+K L+R D +++ F++E + Sbjct: 104 -----LGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSE-----FLKEAHL 153 Query: 509 LAELRHPNIVKFVGAC--RKPIVLVHCHRVCKGWDLL 613 +++ HP+I+K +G C +P L+ + +G DLL Sbjct: 154 MSKFDHPHILKLLGVCLLNEPQYLI--LELMEGGDLL 188
>KIT_CHICK (Q08156) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 960 Score = 42.7 bits (99), Expect = 9e-04 Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 9/95 (9%) Frame = +2 Query: 299 PTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEAD 457 PT+ D++ W +L G GAFGK+ T G M VA+K+L+ Sbjct: 559 PTQLPYDHK-WEFPRNRLSFGKTLGAGAFGKVVEATAYGLFKSDAAMTVAVKMLK----- 612 Query: 458 PPQAQLLEQQ-FVQEVRMLAEL-RHPNIVKFVGAC 556 P A L E++ + E+++L+ L H NIV +GAC Sbjct: 613 -PSAHLTEREALMSELKVLSYLGNHINIVNLLGAC 646
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 42.7 bits (99), Expect = 9e-04 Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 2/81 (2%) Frame = +2 Query: 320 YEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD--VAIKLLERPEADPPQAQLLEQQFV 493 ++E G +G FGK+++GT +D VAIK L+R + +FV Sbjct: 93 FQELAEATGNFRSDCFLGEGGFGKVFKGTIEKLDQVVAIKQLDRNGVQGIR------EFV 146 Query: 494 QEVRMLAELRHPNIVKFVGAC 556 EV L+ HPN+VK +G C Sbjct: 147 VEVLTLSLADHPNLVKLIGFC 167
>FGFR4_MOUSE (Q03142) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) Length = 799 Score = 42.7 bits (99), Expect = 9e-04 Identities = 37/133 (27%), Positives = 59/133 (44%), Gaps = 12/133 (9%) Frame = +2 Query: 221 SIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYR 400 S+ R R+S S L L++ P + L W +L +G P +G FG++ R Sbjct: 428 SLVRGVRLSS--SGPPLLTGLVNLDLPLDPL-----WEFPRDRLVLGKPLGEGCFGQVVR 480 Query: 401 GTYNGMD---------VAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGA 553 GMD VA+K+L+ +D A L+ + V ++ RH NI+ +G Sbjct: 481 AEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIG----RHKNIINLLGV 536 Query: 554 CRKP---IVLVHC 583 C + V+V C Sbjct: 537 CTQEGPLYVIVEC 549
>MOS_CHICK (P10741) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) Length = 349 Score = 42.7 bits (99), Expect = 9e-04 Identities = 23/74 (31%), Positives = 41/74 (55%) Frame = +2 Query: 332 TIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRML 511 +ID +L + P G FG +Y+ TY+G+ VA+K +++ + +L +Q + Sbjct: 58 SIDWDRLCLLQPLGSGGFGAVYKATYHGVTVAVKQVKKSSKN----RLASRQSFWAELNV 113 Query: 512 AELRHPNIVKFVGA 553 A L+H N+V+ V A Sbjct: 114 ARLQHDNVVRVVAA 127
>ROS_CHICK (P08941) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2311 Score = 42.7 bits (99), Expect = 9e-04 Identities = 38/157 (24%), Positives = 74/157 (47%), Gaps = 10/157 (6%) Frame = +2 Query: 173 PSHRGPVAVVSYSVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKL 352 P+ G + +V + R + L++ A + + ++ E+L + ++L KL Sbjct: 1907 PASTGQIVLVKEDKELAQLRGMAETVGLANACYAVSTLPSQAEIESLPAFPRDKLNLHKL 1966 Query: 353 HMGLPFAQGAFGKLYRGTYNGM--------DVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 GAFG++Y GT + VA+K L+R D +++ F++E + Sbjct: 1967 -----LGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSE-----FLKEAHL 2016 Query: 509 LAELRHPNIVKFVGAC--RKPIVLVHCHRVCKGWDLL 613 +++ HP+I+K +G C +P L+ + +G DLL Sbjct: 2017 MSKFDHPHILKLLGVCLLNEPQYLI--LELMEGGDLL 2051
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 42.4 bits (98), Expect = 0.001 Identities = 28/109 (25%), Positives = 50/109 (45%), Gaps = 6/109 (5%) Frame = +2 Query: 242 VSHALSD-DALAQALMDTRFPTETLKDYEE-----WTIDLGKLHMGLPFAQGAFGKLYRG 403 V H +D D L L+ + T+ +E W +++ +L + +G FG + G Sbjct: 153 VEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG 212 Query: 404 TYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 Y G VA+K ++ Q F+ E ++ +LRH N+V+ +G Sbjct: 213 DYRGNKVAVKCIKN--------DATAQAFLAEASVMTQLRHSNLVQLLG 253
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 42.4 bits (98), Expect = 0.001 Identities = 28/109 (25%), Positives = 50/109 (45%), Gaps = 6/109 (5%) Frame = +2 Query: 242 VSHALSD-DALAQALMDTRFPTETLKDYEE-----WTIDLGKLHMGLPFAQGAFGKLYRG 403 V H +D D L L+ + T+ +E W +++ +L + +G FG + G Sbjct: 153 VEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG 212 Query: 404 TYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 Y G VA+K ++ Q F+ E ++ +LRH N+V+ +G Sbjct: 213 DYRGNKVAVKCIKN--------DATAQAFLAEASVMTQLRHSNLVQLLG 253
>VGFR2_HUMAN (P35968) Vascular endothelial growth factor receptor 2 precursor (EC| 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen) Length = 1356 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/91 (28%), Positives = 43/91 (47%), Gaps = 8/91 (8%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-------VAIKLLERPEADPPQAQL 475 D +W +L +G P +GAFG++ G+D VA+K+L+ L Sbjct: 823 DASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRAL 882 Query: 476 LEQQFVQEVRMLAEL-RHPNIVKFVGACRKP 565 + E+++L + H N+V +GAC KP Sbjct: 883 M-----SELKILIHIGHHLNVVNLLGACTKP 908
>VGFR2_MOUSE (P35918) Vascular endothelial growth factor receptor 2 precursor (EC| 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) Length = 1367 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/91 (28%), Positives = 43/91 (47%), Gaps = 8/91 (8%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-------VAIKLLERPEADPPQAQL 475 D +W +L +G P +GAFG++ G+D VA+K+L+ L Sbjct: 821 DASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRAL 880 Query: 476 LEQQFVQEVRMLAEL-RHPNIVKFVGACRKP 565 + E+++L + H N+V +GAC KP Sbjct: 881 M-----SELKILIHIGHHLNVVNLLGACTKP 906
>VGFR2_COTJA (P52583) Vascular endothelial growth factor receptor 2 precursor (EC| 2.7.10.1) (VEGFR-2) (Endothelial kinase receptor EK1) (Quek 1) (Quek1) Length = 1348 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/91 (28%), Positives = 43/91 (47%), Gaps = 8/91 (8%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-------VAIKLLERPEADPPQAQL 475 D +W +L +G P +GAFG++ G+D VA+K+L+ L Sbjct: 814 DASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRAL 873 Query: 476 LEQQFVQEVRMLAEL-RHPNIVKFVGACRKP 565 + E+++L + H N+V +GAC KP Sbjct: 874 M-----SELKILIHIGHHLNVVNLLGACTKP 899
>VGFR3_RAT (Q91ZT1) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1363 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/91 (28%), Positives = 43/91 (47%), Gaps = 8/91 (8%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-------VAIKLLERPEADPPQAQL 475 D +W +LH+G GAFGK+ + G++ VA+K+L+ L Sbjct: 834 DVSQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRAL 893 Query: 476 LEQQFVQEVRMLAEL-RHPNIVKFVGACRKP 565 + E+++L + H N+V +GAC KP Sbjct: 894 M-----SELKILIHIGNHLNVVNLLGACTKP 919
>VGFR2_RAT (O08775) Vascular endothelial growth factor receptor 2 precursor (EC| 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) Length = 1343 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/91 (28%), Positives = 43/91 (47%), Gaps = 8/91 (8%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-------VAIKLLERPEADPPQAQL 475 D +W +L +G P +GAFG++ G+D VA+K+L+ L Sbjct: 819 DASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRAL 878 Query: 476 LEQQFVQEVRMLAEL-RHPNIVKFVGACRKP 565 + E+++L + H N+V +GAC KP Sbjct: 879 M-----SELKILIHIGHHLNVVNLLGACTKP 904
>VGFR3_MOUSE (P35917) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1363 Score = 42.0 bits (97), Expect = 0.001 Identities = 26/91 (28%), Positives = 43/91 (47%), Gaps = 8/91 (8%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-------VAIKLLERPEADPPQAQL 475 D +W +LH+G GAFGK+ + G++ VA+K+L+ L Sbjct: 834 DASQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRAL 893 Query: 476 LEQQFVQEVRMLAEL-RHPNIVKFVGACRKP 565 + E+++L + H N+V +GAC KP Sbjct: 894 M-----SELKILIHIGNHLNVVNLLGACTKP 919
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 42.0 bits (97), Expect = 0.001 Identities = 23/63 (36%), Positives = 36/63 (57%), Gaps = 2/63 (3%) Frame = +2 Query: 374 QGAFGKLYRGTYN--GMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFV 547 +G FG++Y+G + G VA+K L+R ++F+ EV ML+ L HPN+V + Sbjct: 94 EGGFGRVYKGRLDSTGQVVAVKQLDRNGLQG------NREFLVEVLMLSLLHHPNLVNLI 147 Query: 548 GAC 556 G C Sbjct: 148 GYC 150
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 42.0 bits (97), Expect = 0.001 Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 7/95 (7%) Frame = +2 Query: 287 DTRFPTETLKD-------YEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLER 445 DTRF + + + ++E G MG +G FG +Y+G N VA+K L Sbjct: 162 DTRFHSFSFHELKSITNNFDEQPASAGGNRMG----EGGFGVVYKGCVNNTIVAVKKLGA 217 Query: 446 PEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 + L+QQF QE++++A +H N+V+ +G Sbjct: 218 MVEISTEE--LKQQFDQEIKVMATCQHENLVELLG 250
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 42.0 bits (97), Expect = 0.001 Identities = 28/87 (32%), Positives = 46/87 (52%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-VAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + QG FG+++ GT+N VAIK L +P P+A F+QE Sbjct: 257 DAWEIPRESLRLEAKLGQGCFGEVWMGTWNDTTRVAIKTL-KPGTMSPEA------FLQE 309 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +LRH +V+ + +PI +V Sbjct: 310 AQVMKKLRHEKLVQLYAVVSEEPIYIV 336
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 42.0 bits (97), Expect = 0.001 Identities = 37/158 (23%), Positives = 70/158 (44%), Gaps = 10/158 (6%) Frame = +2 Query: 113 MSVDNSSVGSTDSRTGMLNHPSHRGPVAVVSYSVGNSIFRPGRVSHALSDDALAQA-LMD 289 M + N +T + + P R V++ S S NS R++ S D A + + Sbjct: 391 MKMPNKKAMNTTTVQKVSKFPLKRQQVSLESNSSMNSNTPLVRITRLSSSDGPMLANVSE 450 Query: 290 TRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD---------VAIKLLE 442 P + +W + +L +G P +G FG++ G+D VA+K+L+ Sbjct: 451 LELPPDP-----KWELARSRLTLGKPLGEGCFGQVVMAEAIGIDKDKPNKAITVAVKMLK 505 Query: 443 RPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGAC 556 D + L+ + ++ ++M+ +H NI+ +GAC Sbjct: 506 DDATDKDLSDLVSE--MEMMKMIG--KHKNIINLLGAC 539
>DAF1_CAEEL (P20792) Cell-surface receptor daf-1 precursor (EC 2.7.11.30)| (Abnormal dauer formation protein 1) Length = 669 Score = 42.0 bits (97), Expect = 0.001 Identities = 39/124 (31%), Positives = 60/124 (48%), Gaps = 2/124 (1%) Frame = +2 Query: 194 AVVSYSVGNSIFRPGRVSHALSD--DALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLP 367 + +S S GNS F PG + + + D D L + PT K TI G++ + Sbjct: 245 STMSTSAGNS-FPPGIMPNNMKDMLDVLEETSGSGMGPTTLHK----LTIG-GQIRLTGR 298 Query: 368 FAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFV 547 G FG + RG Y G VA+K+ D P ++ + E RM LRHPN+++++ Sbjct: 299 VGSGRFGNVSRGDYRGEAVAVKVFN--ALDEPAFH--KETEIFETRM---LRHPNVLRYI 351 Query: 548 GACR 559 G+ R Sbjct: 352 GSDR 355
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 41.6 bits (96), Expect = 0.002 Identities = 19/81 (23%), Positives = 44/81 (54%), Gaps = 2/81 (2%) Frame = +2 Query: 320 YEEWTIDLGKLHMGLPFAQGAFGKLYRGTYN--GMDVAIKLLERPEADPPQAQLLEQQFV 493 +++W ++ + M G +G++Y G + + VA+K L+ + ++F+ Sbjct: 278 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV-------EEFL 330 Query: 494 QEVRMLAELRHPNIVKFVGAC 556 +E ++ E++HPN+V+ +G C Sbjct: 331 KEAAVMKEIKHPNLVQLLGVC 351
>FGFR4_RAT (Q498D6) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) Length = 800 Score = 41.6 bits (96), Expect = 0.002 Identities = 33/121 (27%), Positives = 56/121 (46%), Gaps = 9/121 (7%) Frame = +2 Query: 221 SIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYR 400 S+ R R+S S L L+ P + L W +L +G P +G FG++ R Sbjct: 429 SLVRGVRLSS--SGPPLLTGLVSLDLPLDPL-----WEFPRDRLVLGKPLGEGCFGQVVR 481 Query: 401 GTYNGMD---------VAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGA 553 GMD VA+K+L+ +D A L+ + ++ ++++ RH NI+ +G Sbjct: 482 AEALGMDSSRPDQTSTVAVKMLKDNASDKDLADLISE--MEMMKLIG--RHKNIINLLGV 537 Query: 554 C 556 C Sbjct: 538 C 538
>ROR2_DROME (Q9V6K3) Tyrosine-protein kinase transmembrane receptor Ror2| precursor (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase) Length = 724 Score = 41.6 bits (96), Expect = 0.002 Identities = 23/68 (33%), Positives = 38/68 (55%), Gaps = 7/68 (10%) Frame = +2 Query: 374 QGAFGKLYRGTYNGMD-------VAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPN 532 QGAFG++++ G+ VA+K+L+ +D ++ F +E +LAE HPN Sbjct: 449 QGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQ-----MQMDFEREACLLAEFDHPN 503 Query: 533 IVKFVGAC 556 IV+ +G C Sbjct: 504 IVRLLGVC 511
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 41.6 bits (96), Expect = 0.002 Identities = 21/82 (25%), Positives = 42/82 (51%), Gaps = 2/82 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYN--GMDVAIKLLERPEADPPQAQLLEQQFVQ 496 +EW I + M G +G++Y + G VA+K L+ + + + F++ Sbjct: 362 DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLK-------EDTMALKDFLE 414 Query: 497 EVRMLAELRHPNIVKFVGACRK 562 E ++ E++HPN+V+ +G C + Sbjct: 415 EAAIMKEMKHPNLVQLIGVCTR 436
>LRRK2_MOUSE (Q5S006) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 2527 Score = 41.6 bits (96), Expect = 0.002 Identities = 22/67 (32%), Positives = 38/67 (56%) Frame = +2 Query: 377 GAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGAC 556 G+FG +YR Y G +VA+K+ + + +LL Q+ V +L L HP+++ + A Sbjct: 1888 GSFGSVYRAAYEGEEVAVKIFNKHTS----LRLLRQELV----VLCHLHHPSLISLLAAG 1939 Query: 557 RKPIVLV 577 +P +LV Sbjct: 1940 IRPRMLV 1946
>LRRK2_HUMAN (Q5S007) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) (Dardarin) Length = 2527 Score = 41.6 bits (96), Expect = 0.002 Identities = 22/67 (32%), Positives = 38/67 (56%) Frame = +2 Query: 377 GAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGAC 556 G+FG +YR Y G +VA+K+ + + +LL Q+ V +L L HP+++ + A Sbjct: 1888 GSFGSVYRAAYEGEEVAVKIFNKHTS----LRLLRQELV----VLCHLHHPSLISLLAAG 1939 Query: 557 RKPIVLV 577 +P +LV Sbjct: 1940 IRPRMLV 1946
>MOS_MOUSE (P00536) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 390 Score = 41.2 bits (95), Expect = 0.003 Identities = 26/75 (34%), Positives = 42/75 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 ++ID ++ + G FG +Y+ TY+G+ VAIK + + D +Q + F E+ Sbjct: 103 FSIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDLRASQ---RSFWAELN- 158 Query: 509 LAELRHPNIVKFVGA 553 +A LRH NIV+ V A Sbjct: 159 IARLRHDNIVRVVAA 173
>PGFRA_HUMAN (P16234) Alpha platelet-derived growth factor receptor precursor| (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen) Length = 1089 Score = 41.2 bits (95), Expect = 0.003 Identities = 39/124 (31%), Positives = 58/124 (46%), Gaps = 11/124 (8%) Frame = +2 Query: 239 RVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG- 415 RV ++S D +D P + D W L +G GAFGK+ GT G Sbjct: 560 RVIESISPDGHEYIYVD---PMQLPYD-SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGL 615 Query: 416 ------MDVAIKLLERPEADPPQAQLLEQQ-FVQEVRMLAEL-RHPNIVKFVGACRK--P 565 M VA+K+L+ P A+ E+Q + E++++ L H NIV +GAC K P Sbjct: 616 SRSQPVMKVAVKMLK------PTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGP 669 Query: 566 IVLV 577 I ++ Sbjct: 670 IYII 673
>ROR1_HUMAN (Q01973) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) Length = 937 Score = 41.2 bits (95), Expect = 0.003 Identities = 29/64 (45%), Positives = 39/64 (60%), Gaps = 6/64 (9%) Frame = +2 Query: 380 AFGKLYRGTYN--GMD----VAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVK 541 AFGK+Y+G GMD VAIK L+ + + PQ + +F QE ++AEL HPNIV Sbjct: 483 AFGKIYKGHLYLPGMDHAQLVAIKTLK--DYNNPQQWM---EFQQEASLMAELHHPNIVC 537 Query: 542 FVGA 553 +GA Sbjct: 538 LLGA 541
>FAK1_CHICK (Q00944) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1053 Score = 41.2 bits (95), Expect = 0.003 Identities = 24/88 (27%), Positives = 44/88 (50%), Gaps = 5/88 (5%) Frame = +2 Query: 302 TETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-----MDVAIKLLERPEADPPQ 466 T T+ ++ I ++ +G +G FG +++G Y M VAIK + +D Sbjct: 406 TYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDS-- 463 Query: 467 AQLLEQQFVQEVRMLAELRHPNIVKFVG 550 + ++F+QE + + HP+IVK +G Sbjct: 464 ---VREKFLQEALTMRQFDHPHIVKLIG 488
>MOS_MSVTS (P10421) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 342 Score = 41.2 bits (95), Expect = 0.003 Identities = 26/75 (34%), Positives = 42/75 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 ++ID ++ + G FG +Y+ TY+G+ VAIK + + D +Q + F E+ Sbjct: 56 FSIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDLRASQ---RSFWAELN- 111 Query: 509 LAELRHPNIVKFVGA 553 +A LRH NIV+ V A Sbjct: 112 IARLRHDNIVRVVAA 126
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 41.2 bits (95), Expect = 0.003 Identities = 26/75 (34%), Positives = 42/75 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 ++ID ++ + G FG +Y+ TY+G+ VAIK + + D +Q + F E+ Sbjct: 87 FSIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDLRASQ---RSFWAELN- 142 Query: 509 LAELRHPNIVKFVGA 553 +A LRH NIV+ V A Sbjct: 143 IARLRHDNIVRVVAA 157
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 41.2 bits (95), Expect = 0.003 Identities = 28/109 (25%), Positives = 49/109 (44%), Gaps = 6/109 (5%) Frame = +2 Query: 242 VSHALSD-DALAQALMDTRFPTETLKDYEE-----WTIDLGKLHMGLPFAQGAFGKLYRG 403 V H +D D L L+ + T+ +E W +++ L + +G FG + G Sbjct: 153 VEHYTTDADGLCSRLIKPKVMEGTVAAQDEFSRSGWALNMKDLKLLQIIGKGEFGDVMLG 212 Query: 404 TYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 Y G VA+K ++ Q F+ E ++ +LRH N+V+ +G Sbjct: 213 DYRGNKVAVKCIKN--------DATAQAFLAEASVMTQLRHSNLVQLLG 253
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 41.2 bits (95), Expect = 0.003 Identities = 26/75 (34%), Positives = 42/75 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 ++ID ++ + G FG +Y+ TY+G+ VAIK + + D +Q + F E+ Sbjct: 87 FSIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDLRASQ---RSFWAELN- 142 Query: 509 LAELRHPNIVKFVGA 553 +A LRH NIV+ V A Sbjct: 143 IARLRHDNIVRVVAA 157
>FAK1_RAT (O35346) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1055 Score = 40.8 bits (94), Expect = 0.003 Identities = 37/147 (25%), Positives = 66/147 (44%), Gaps = 9/147 (6%) Frame = +2 Query: 137 GSTDSRTGMLNHPSHRGPVAVVSYSVGNSIFRPGRVSHALS----DDALAQALMDTRFPT 304 G+T S + P G A+ S + + G +HA+S DD + + Sbjct: 353 GATQS---FIIRPQKEGERALPSIPKLANNEKQGMRTHAVSVSETDDYAEIIDEEDTYTM 409 Query: 305 ETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTY-----NGMDVAIKLLERPEADPPQA 469 + +DYE I ++ +G +G FG +++G Y + VAIK + +D Sbjct: 410 PSTRDYE---IQRERIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSDS--- 463 Query: 470 QLLEQQFVQEVRMLAELRHPNIVKFVG 550 + ++F+QE + + HP+IVK +G Sbjct: 464 --VREKFLQEALTMRQFDHPHIVKLIG 488
>PGFRA_RAT (P20786) Alpha platelet-derived growth factor receptor precursor| (EC 2.7.10.1) (PDGF-R-alpha) Length = 1088 Score = 40.8 bits (94), Expect = 0.003 Identities = 39/124 (31%), Positives = 58/124 (46%), Gaps = 11/124 (8%) Frame = +2 Query: 239 RVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG- 415 RV ++S D +D P + D W L +G GAFGK+ GT G Sbjct: 559 RVIESISPDGHEYIYVD---PMQLPYD-SRWEFPRDGLVLGRILGSGAFGKVVEGTAYGL 614 Query: 416 ------MDVAIKLLERPEADPPQAQLLEQQ-FVQEVRMLAEL-RHPNIVKFVGACRK--P 565 M VA+K+L+ P A+ E+Q + E++++ L H NIV +GAC K P Sbjct: 615 SRSQPVMKVAVKMLK------PTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGP 668 Query: 566 IVLV 577 I ++ Sbjct: 669 IYII 672
>PGFRA_MOUSE (P26618) Alpha platelet-derived growth factor receptor precursor| (EC 2.7.10.1) (PDGF-R-alpha) Length = 1089 Score = 40.8 bits (94), Expect = 0.003 Identities = 39/124 (31%), Positives = 58/124 (46%), Gaps = 11/124 (8%) Frame = +2 Query: 239 RVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG- 415 RV ++S D +D P + D W L +G GAFGK+ GT G Sbjct: 560 RVIESISPDGHEYIYVD---PMQLPYD-SRWEFPRDGLVLGRILGSGAFGKVVEGTAYGL 615 Query: 416 ------MDVAIKLLERPEADPPQAQLLEQQ-FVQEVRMLAEL-RHPNIVKFVGACRK--P 565 M VA+K+L+ P A+ E+Q + E++++ L H NIV +GAC K P Sbjct: 616 SRSQPVMKVAVKMLK------PTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGP 669 Query: 566 IVLV 577 I ++ Sbjct: 670 IYII 673
>VGFR3_HUMAN (P35916) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1298 Score = 40.8 bits (94), Expect = 0.003 Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 8/91 (8%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGM-------DVAIKLLERPEADPPQAQL 475 D +W +LH+G GAFGK+ + G+ VA+K+L+ L Sbjct: 834 DASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRAL 893 Query: 476 LEQQFVQEVRMLAEL-RHPNIVKFVGACRKP 565 + E+++L + H N+V +GAC KP Sbjct: 894 M-----SELKILIHIGNHLNVVNLLGACTKP 919
>FLT3_HUMAN (P36888) FL cytokine receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen) Length = 993 Score = 40.4 bits (93), Expect = 0.004 Identities = 32/101 (31%), Positives = 50/101 (49%), Gaps = 13/101 (12%) Frame = +2 Query: 314 KDYE---EWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEADPP 463 ++YE +W L G GAFGK+ T G + VA+K+L + +AD Sbjct: 595 REYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKML-KEKADSS 653 Query: 464 QAQLLEQQFVQEVRMLAEL-RHPNIVKFVGAC--RKPIVLV 577 + + L + E++M+ +L H NIV +GAC PI L+ Sbjct: 654 EREAL----MSELKMMTQLGSHENIVNLLGACTLSGPIYLI 690
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 40.4 bits (93), Expect = 0.004 Identities = 23/71 (32%), Positives = 40/71 (56%), Gaps = 6/71 (8%) Frame = +2 Query: 377 GAFGKLYRGTYNG------MDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIV 538 GAFG +Y+G + + VAIK+L E P+A + +F+ E ++A + HP++V Sbjct: 727 GAFGTVYKGIWVPEGETVKIPVAIKILN--ETTGPKANV---EFMDEALIMASMDHPHLV 781 Query: 539 KFVGACRKPIV 571 + +G C P + Sbjct: 782 RLLGVCLSPTI 792
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 40.4 bits (93), Expect = 0.004 Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 2/92 (2%) Frame = +2 Query: 308 TLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQ 484 ++K + W I L + G FG+++ GT+NG VA+K L +P P+A Sbjct: 255 SVKTKDVWEIPRESLQLLQKLGNGQFGEVWMGTWNGTTKVAVKTL-KPGTMSPEA----- 308 Query: 485 QFVQEVRMLAELRHPNIVK-FVGACRKPIVLV 577 F++E +++ LRH +V+ + +PI +V Sbjct: 309 -FLEEAQIMKRLRHDKLVQLYAVVSEEPIYIV 339
>TOR_DROME (P18475) Tyrosine-protein kinase receptor torso precursor (EC| 2.7.10.1) Length = 923 Score = 40.4 bits (93), Expect = 0.004 Identities = 30/94 (31%), Positives = 49/94 (52%), Gaps = 1/94 (1%) Frame = +2 Query: 272 AQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPE 451 + L+ T E+L+ +E ++ + + +GAFG + RG Y VA+KLL+ Sbjct: 449 SSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLVRRGVYKKRQVAVKLLK--- 505 Query: 452 ADPPQAQLLEQQFVQEVRMLAEL-RHPNIVKFVG 550 D P + + F E++ML + +HPNIV VG Sbjct: 506 -DEPNDEDV-YAFKCEIQMLKAVGKHPNIVGIVG 537
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 40.4 bits (93), Expect = 0.004 Identities = 21/76 (27%), Positives = 36/76 (47%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 W + L +G +GAFG++ N VA+K+++ D A L+ + V ++ Sbjct: 409 WELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIG 468 Query: 509 LAELRHPNIVKFVGAC 556 RH NI+ +G C Sbjct: 469 ----RHINIINLLGCC 480
>RET_MOUSE (P35546) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1115 Score = 40.4 bits (93), Expect = 0.004 Identities = 27/108 (25%), Positives = 55/108 (50%), Gaps = 11/108 (10%) Frame = +2 Query: 287 DTRFPTETLKDYEE--WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-------VAIKLL 439 + + P ++ K E+ W L +G +G FGK+ + T + VA+K+L Sbjct: 702 ENQVPVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKML 761 Query: 440 ERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGACRK--PIVLV 577 + + Q++L + + E +L ++ HP+++K GAC + P++L+ Sbjct: 762 KE---NASQSEL--RDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLI 804
>FAK1_HUMAN (Q05397) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| (Protein-tyrosine kinase 2) Length = 1052 Score = 40.4 bits (93), Expect = 0.004 Identities = 34/135 (25%), Positives = 61/135 (45%), Gaps = 9/135 (6%) Frame = +2 Query: 173 PSHRGPVAVVSYSVGNSIFRPGRVSHALS----DDALAQALMDTRFPTETLKDYEEWTID 340 P G A+ S + + G +HA+S DD + + + +DYE I Sbjct: 362 PQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYE---IQ 418 Query: 341 LGKLHMGLPFAQGAFGKLYRGTYNGMD-----VAIKLLERPEADPPQAQLLEQQFVQEVR 505 ++ +G +G FG +++G Y + VAIK + +D + ++F+QE Sbjct: 419 RERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDS-----VREKFLQEAL 473 Query: 506 MLAELRHPNIVKFVG 550 + + HP+IVK +G Sbjct: 474 TMRQFDHPHIVKLIG 488
>MOS_MSVMT (P32593) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 354 Score = 40.4 bits (93), Expect = 0.004 Identities = 26/75 (34%), Positives = 42/75 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 ++ID ++ + G FG +Y+ TY+G+ VAIK + + D +Q + F E+ Sbjct: 67 FSIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTEDLRASQ---RSFWAELN- 122 Query: 509 LAELRHPNIVKFVGA 553 +A LRH NIV+ V A Sbjct: 123 IAGLRHDNIVRVVAA 137
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 40.4 bits (93), Expect = 0.004 Identities = 26/87 (29%), Positives = 42/87 (48%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTY-NGMDVAIKLLERPEADPPQAQLLEQQFVQE 499 +EW I L + G FG+++ G Y N M VAIK L+ P + F+ E Sbjct: 231 DEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSP-------EAFLGE 283 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 M+ L+H +V+ + ++PI +V Sbjct: 284 ANMMKALQHERLVRLYAVVTKEPIYIV 310
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 40.4 bits (93), Expect = 0.004 Identities = 25/72 (34%), Positives = 40/72 (55%), Gaps = 4/72 (5%) Frame = +2 Query: 359 GLPFAQGAFGKLYRGTY--NGMDVAIK--LLERPEADPPQAQLLEQQFVQEVRMLAELRH 526 G +GAFG +Y G +G +A+K L+ A + Q Q+ +EV++L L H Sbjct: 72 GQLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSH 131 Query: 527 PNIVKFVGACRK 562 PNIV+++G R+ Sbjct: 132 PNIVRYLGTVRE 143
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 40.4 bits (93), Expect = 0.004 Identities = 24/87 (27%), Positives = 43/87 (49%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQFVQE 499 +EW + L + G FG+++ G YNG VAIK L++ P F+ E Sbjct: 234 DEWEVPRESLKLVEKLGAGQFGEVWMGFYNGHTKVAIKNLKQGSMSP-------SAFLAE 286 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 ++ L+HP +V+ + ++PI ++ Sbjct: 287 ANLMKNLQHPRLVRLYAVVTKEPIYII 313
>MOS_MSVMO (P00538) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 40.4 bits (93), Expect = 0.004 Identities = 26/75 (34%), Positives = 42/75 (56%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 ++ID ++ + G FG +Y+ TY+G+ VAIK + + D +Q + F E+ Sbjct: 87 FSIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTEDLRASQ---RSFWAELN- 142 Query: 509 LAELRHPNIVKFVGA 553 +A LRH NIV+ V A Sbjct: 143 IAGLRHDNIVRVVAA 157
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 40.0 bits (92), Expect = 0.006 Identities = 23/71 (32%), Positives = 40/71 (56%), Gaps = 6/71 (8%) Frame = +2 Query: 377 GAFGKLYRGTYNG------MDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIV 538 GAFG +Y+G + + VAIK+L E P+A + +F+ E ++A + HP++V Sbjct: 727 GAFGTVYKGIWVPEGETVKIPVAIKILN--ETTGPKANV---EFMDEALIMASVDHPHLV 781 Query: 539 KFVGACRKPIV 571 + +G C P + Sbjct: 782 RLLGVCLSPTI 792
>FLT3_MOUSE (Q00342) FL cytokine receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) Length = 992 Score = 40.0 bits (92), Expect = 0.006 Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 11/102 (10%) Frame = +2 Query: 284 MDTRFPTETLKDYE---EWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-------VAIK 433 +D + +DYE +W L G GAFG++ T G+ VA+K Sbjct: 586 LDNEYFYVDFRDYEYDLKWEFPRENLEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVK 645 Query: 434 LLERPEADPPQAQLLEQQFVQEVRMLAEL-RHPNIVKFVGAC 556 +L+ +AD + + L + E++M+ L H NIV +GAC Sbjct: 646 MLKE-KADSCEKEAL----MSELKMMTHLGHHDNIVNLLGAC 682
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 40.0 bits (92), Expect = 0.006 Identities = 23/87 (26%), Positives = 44/87 (50%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQFVQE 499 +EW + L + G FG+++ G YNG VA+K L++ P F+ E Sbjct: 235 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSP-------DAFLAE 287 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 ++ +L+HP +V+ + ++PI ++ Sbjct: 288 ANLMKQLQHPRLVRLYAVVTQEPIYII 314
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 40.0 bits (92), Expect = 0.006 Identities = 23/71 (32%), Positives = 37/71 (52%), Gaps = 3/71 (4%) Frame = +2 Query: 374 QGAFGKLYRGT-YNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 +GAFGK++ YN +K+L +A + F +E +L L+H +IVKF G Sbjct: 546 EGAFGKVFLAECYNLSPTKVKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYG 605 Query: 551 AC--RKPIVLV 577 C P+++V Sbjct: 606 VCGDGDPLIMV 616
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 40.0 bits (92), Expect = 0.006 Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 2/99 (2%) Frame = +2 Query: 260 DDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLY--RGTYNGMDVAIK 433 + A Q DT+ TL+D++ +G P +G FG +Y R + +A+K Sbjct: 104 EQASLQKTEDTKKRQWTLEDFD----------IGRPLGKGKFGNVYLARERQSKFILALK 153 Query: 434 LLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 +L + + + +E Q +EV + + LRHPNI++ G Sbjct: 154 VLFKTQLEKAN---VEHQLRREVEIQSHLRHPNILRLYG 189
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 40.0 bits (92), Expect = 0.006 Identities = 25/72 (34%), Positives = 40/72 (55%), Gaps = 4/72 (5%) Frame = +2 Query: 359 GLPFAQGAFGKLYRGTY--NGMDVAIK--LLERPEADPPQAQLLEQQFVQEVRMLAELRH 526 G +GAFG +Y G +G +A+K L+ A + Q Q+ +EV++L L H Sbjct: 71 GQLIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSH 130 Query: 527 PNIVKFVGACRK 562 PNIV+++G R+ Sbjct: 131 PNIVRYLGTVRE 142
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 40.0 bits (92), Expect = 0.006 Identities = 25/92 (27%), Positives = 47/92 (51%), Gaps = 2/92 (2%) Frame = +2 Query: 308 TLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQ 484 ++K + W I L + G FG+++ GT+NG VA+K L+ P + Sbjct: 256 SVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSP-------E 308 Query: 485 QFVQEVRMLAELRHPNIVK-FVGACRKPIVLV 577 F++E +++ +LRH +V+ + +PI +V Sbjct: 309 SFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIV 340
>CDKL1_RAT (Q66HE7) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 40.0 bits (92), Expect = 0.006 Identities = 24/77 (31%), Positives = 43/77 (55%), Gaps = 6/77 (7%) Frame = +2 Query: 374 QGAFGKLY--RGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFV 547 +G++G ++ R G VAIK E DP ++++ ++E+RML +L+HPN+V + Sbjct: 12 EGSYGVVFKCRNRDTGQIVAIKRFLETEDDP----VIKKIALREIRMLKQLKHPNLVSLL 67 Query: 548 GACRKP----IVLVHCH 586 R+ +V +CH Sbjct: 68 EVFRRKRRLHLVFEYCH 84
>MOS_PIG (P50118) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 345 Score = 40.0 bits (92), Expect = 0.006 Identities = 23/59 (38%), Positives = 33/59 (55%) Frame = +2 Query: 377 GAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGA 553 G FG +Y+ TY+G+ VAIK + R + +L Q+ +A LRH NIV+ V A Sbjct: 72 GGFGSVYKATYHGVPVAIKQVSRCTKN----RLASQRSFWAELNIARLRHANIVRVVAA 126
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 40.0 bits (92), Expect = 0.006 Identities = 34/136 (25%), Positives = 66/136 (48%), Gaps = 2/136 (1%) Frame = +2 Query: 140 STDSRTGMLNHPSHRGPVAVVSYSVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKD 319 +T S+ + P+ +A+V+ S S PG+ LA+ ++ ++ Sbjct: 22 NTLSQRVLRKEPATTSALALVNRSNSQSTAAPGQ--------KLAENKSQGSTASQGSQN 73 Query: 320 YEEWTIDLGKLHMGLPFAQGAFGKLY--RGTYNGMDVAIKLLERPEADPPQAQLLEQQFV 493 + +TID +G P +G FG +Y R + VA+K+L + + + + +E Q Sbjct: 74 KQPFTID--NFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEK---EGVEHQLR 128 Query: 494 QEVRMLAELRHPNIVK 541 +E+ + A L+HPNI++ Sbjct: 129 REIEIQAHLKHPNILQ 144
>FGFR3_HUMAN (P22607) Fibroblast growth factor receptor 3 precursor (EC| 2.7.10.1) (FGFR-3) (CD333 antigen) Length = 806 Score = 39.7 bits (91), Expect = 0.007 Identities = 22/86 (25%), Positives = 44/86 (51%), Gaps = 9/86 (10%) Frame = +2 Query: 326 EWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD---------VAIKLLERPEADPPQAQLL 478 +W + +L +G P +G FG++ G+D VA+K+L+ D + L+ Sbjct: 464 KWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLV 523 Query: 479 EQQFVQEVRMLAELRHPNIVKFVGAC 556 + ++ ++M+ +H NI+ +GAC Sbjct: 524 SE--MEMMKMIG--KHKNIINLLGAC 545
>FAK1_XENLA (Q91738) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1068 Score = 39.7 bits (91), Expect = 0.007 Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 5/83 (6%) Frame = +2 Query: 317 DYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-----MDVAIKLLERPEADPPQAQLLE 481 DYE I ++ +G +G FG +++G Y M VAIK + +D + Sbjct: 427 DYE---IQRDRIELGRCIGEGQFGDVHQGVYMSPENPAMAVAIKTCKNCTSDS-----VR 478 Query: 482 QQFVQEVRMLAELRHPNIVKFVG 550 ++F+QE + + HP+IVK +G Sbjct: 479 EKFLQEALTMRQFDHPHIVKLIG 501
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 39.7 bits (91), Expect = 0.007 Identities = 24/75 (32%), Positives = 38/75 (50%), Gaps = 2/75 (2%) Frame = +2 Query: 332 TIDLGKLHMGLPFAQGAFGKLY--RGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVR 505 ++ L +G +G FGK+Y R G A+K++E+ E L++QF +EV Sbjct: 98 SLSLDDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYN---LQKQFRREVE 154 Query: 506 MLAELRHPNIVKFVG 550 + L HPN+ K G Sbjct: 155 IQTSLNHPNLTKSYG 169
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 39.7 bits (91), Expect = 0.007 Identities = 20/62 (32%), Positives = 35/62 (56%), Gaps = 1/62 (1%) Frame = +2 Query: 374 QGAFGKLYRGTY-NGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 QG FG +Y+G +G ++A+K L + +F+ EV ++A L+H N+V+ +G Sbjct: 536 QGGFGIVYKGRLLDGKEIAVKRLSKTSVQGTD------EFMNEVTLIARLQHINLVQVLG 589 Query: 551 AC 556 C Sbjct: 590 CC 591
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 39.7 bits (91), Expect = 0.007 Identities = 23/69 (33%), Positives = 37/69 (53%), Gaps = 2/69 (2%) Frame = +2 Query: 341 LGKLHMGLPFAQGAFGK--LYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLA 514 +G + +G F K L R G +VA+K++++ + +P Q L +EVR++ Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKL----FREVRIMK 112 Query: 515 ELRHPNIVK 541 L HPNIVK Sbjct: 113 ILNHPNIVK 121
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 39.7 bits (91), Expect = 0.007 Identities = 23/69 (33%), Positives = 37/69 (53%), Gaps = 2/69 (2%) Frame = +2 Query: 341 LGKLHMGLPFAQGAFGK--LYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLA 514 +G + +G F K L R G +VA+K++++ + +P Q L +EVR++ Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKL----FREVRIMK 112 Query: 515 ELRHPNIVK 541 L HPNIVK Sbjct: 113 ILNHPNIVK 121
>MOS_APTAU (P87347) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 39.7 bits (91), Expect = 0.007 Identities = 20/63 (31%), Positives = 34/63 (53%) Frame = +2 Query: 365 PFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKF 544 P G FG +Y+ TY+G VA+K +++ + +L +Q +A L+H N+V+ Sbjct: 7 PLGSGGFGSVYKATYHGATVAVKQVKKSSKN----RLASRQSFWAELNVARLQHANVVRV 62 Query: 545 VGA 553 V A Sbjct: 63 VAA 65
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 39.7 bits (91), Expect = 0.007 Identities = 20/78 (25%), Positives = 36/78 (46%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 +EW +D ++ M G +G +Y G + D I + E P +F+ E Sbjct: 302 DEWELDRSEIIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPL-----HEFLAEA 356 Query: 503 RMLAELRHPNIVKFVGAC 556 ++ +L H N+V+ +G C Sbjct: 357 AIMKDLHHKNLVRLLGVC 374
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 39.7 bits (91), Expect = 0.007 Identities = 23/69 (33%), Positives = 37/69 (53%), Gaps = 2/69 (2%) Frame = +2 Query: 341 LGKLHMGLPFAQGAFGK--LYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLA 514 +G + +G F K L R G +VA+K++++ + +P Q L +EVR++ Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKL----FREVRIMK 112 Query: 515 ELRHPNIVK 541 L HPNIVK Sbjct: 113 ILNHPNIVK 121
>DUN1_YEAST (P39009) DNA damage response protein kinase DUN1 (EC 2.7.11.1)| Length = 513 Score = 39.7 bits (91), Expect = 0.007 Identities = 30/124 (24%), Positives = 56/124 (45%), Gaps = 2/124 (1%) Frame = +2 Query: 203 SYSVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTI--DLGKLHMGLPFAQ 376 SY + +F+ ++S S +A A + T + ++++ + +LG H L Sbjct: 158 SYKNDDEVFKKPQISATSSQNATTSAAIRKLNKTRPVSFFDKYLLGKELGAGHYALV--- 214 Query: 377 GAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGAC 556 K + G VA+K+ + D Q +QF +E +L ++HPNIV + + Sbjct: 215 ----KEAKNKKTGQQVAVKIFHAQQNDD---QKKNKQFREETNILMRVQHPNIVNLLDSF 267 Query: 557 RKPI 568 +PI Sbjct: 268 VEPI 271
>SRK1_SCHPO (O94547) Serine/threonine-protein kinase srk1 (EC 2.7.11.1)| (Sty1-regulated kinase 1) Length = 580 Score = 39.7 bits (91), Expect = 0.007 Identities = 32/113 (28%), Positives = 59/113 (52%), Gaps = 8/113 (7%) Frame = +2 Query: 251 ALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYN--GMDV 424 AL A+ + +FP K E++T+ L K+ GAF +Y+ +N G V Sbjct: 100 ALVAKAIVEEHSGQQFPV--YKGLEQYTL-LQKM------GDGAFSNVYKAIHNRTGEKV 150 Query: 425 AIKLLERPEA-----DPPQAQLLEQQ-FVQEVRMLAELRHPNIVKFVGACRKP 565 AIK+++R + DP + Q +E ++EV+++ ++HPNI++ + + P Sbjct: 151 AIKVVQRAQPNTDPRDPRKRQGVESHNILKEVQIMRRVKHPNIIQLLEFIQTP 203
>BLK_MOUSE (P16277) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 498 Score = 39.7 bits (91), Expect = 0.007 Identities = 26/87 (29%), Positives = 42/87 (48%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTY-NGMDVAIKLLERPEADPPQAQLLEQQFVQE 499 +EW I L + G FG+++ G Y N M VAIK L+ P + F+ E Sbjct: 225 DEWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSP-------EAFLGE 277 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 ++ L+H +V+ + R+PI +V Sbjct: 278 ANVMKTLQHERLVRLYAVVTREPIYIV 304
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 39.3 bits (90), Expect = 0.010 Identities = 21/51 (41%), Positives = 31/51 (60%) Frame = +2 Query: 389 KLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVK 541 KL R G +VAIK++++ + +P Q L +EVR++ L HPNIVK Sbjct: 74 KLARHILTGREVAIKIIDKTQLNPSSLQKL----FREVRIMKGLNHPNIVK 120
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 39.3 bits (90), Expect = 0.010 Identities = 21/51 (41%), Positives = 31/51 (60%) Frame = +2 Query: 389 KLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVK 541 KL R G +VAIK++++ + +P Q L +EVR++ L HPNIVK Sbjct: 74 KLARHILTGREVAIKIIDKTQLNPSSLQKL----FREVRIMKGLNHPNIVK 120
>MOS_VULGR (Q90XV7) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 39.3 bits (90), Expect = 0.010 Identities = 20/63 (31%), Positives = 34/63 (53%) Frame = +2 Query: 365 PFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKF 544 P G FG +Y+ TY+G VA+K +++ + +L +Q +A L+H N+V+ Sbjct: 7 PLGSGGFGSVYKATYHGATVAVKQVKKSSKN----RLASRQSFWAELNVARLQHNNVVRV 62 Query: 545 VGA 553 V A Sbjct: 63 VAA 65
>MOS_GYMCA (Q90XV6) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 39.3 bits (90), Expect = 0.010 Identities = 20/63 (31%), Positives = 34/63 (53%) Frame = +2 Query: 365 PFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKF 544 P G FG +Y+ TY+G VA+K +++ + +L +Q +A L+H N+V+ Sbjct: 7 PLGSGGFGSVYKATYHGATVAVKQVKKSSKN----RLASRQSFWAELNVARLQHNNVVRV 62 Query: 545 VGA 553 V A Sbjct: 63 VAA 65
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 39.3 bits (90), Expect = 0.010 Identities = 29/127 (22%), Positives = 58/127 (45%), Gaps = 9/127 (7%) Frame = +2 Query: 203 SYSVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGA 382 S + G + RP R+S S + + + P + W + +L +G P +G Sbjct: 434 SMNSGVMLVRPSRLSS--SGTPMLAGVSEYELPEDP-----RWELPRDRLILGKPLGEGC 486 Query: 383 FGKLYRGTYNGMD---------VAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNI 535 FG++ G+D VA+K+L+ + + L+ + ++ ++M+ +H NI Sbjct: 487 FGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE--MEMMKMIG--KHKNI 542 Query: 536 VKFVGAC 556 + +GAC Sbjct: 543 INLLGAC 549
>UFO_HUMAN (P30530) Tyrosine-protein kinase receptor UFO precursor (EC| 2.7.10.1) (AXL oncogene) Length = 887 Score = 39.3 bits (90), Expect = 0.010 Identities = 31/138 (22%), Positives = 58/138 (42%), Gaps = 1/138 (0%) Frame = +2 Query: 146 DSRTGMLNHPSHRGPVAVVSYSVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKD-Y 322 ++R G + P+ VV Y V S R +A +++ +E LK+ Sbjct: 471 ETRYGEVFEPTVERGELVVRYRVRKSYSR-----------RTTEATLNSLGISEELKEKL 519 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 + +D K+ +G +G FG + G N D +K+ + + + F+ E Sbjct: 520 RDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEA 579 Query: 503 RMLAELRHPNIVKFVGAC 556 + E HPN+++ +G C Sbjct: 580 VCMKEFDHPNVMRLIGVC 597
>RET_HUMAN (P07949) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1114 Score = 39.3 bits (90), Expect = 0.010 Identities = 28/109 (25%), Positives = 53/109 (48%), Gaps = 11/109 (10%) Frame = +2 Query: 284 MDTRFPTETLKDYEE--WTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-------VAIKL 436 M+ + + K E+ W L +G +G FGK+ + T + VA+K+ Sbjct: 700 MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKM 759 Query: 437 LERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGACRK--PIVLV 577 L+ A P + + L +F +L ++ HP+++K GAC + P++L+ Sbjct: 760 LKE-NASPSELRDLLSEF----NVLKQVNHPHVIKLYGACSQDGPLLLI 803
>UFO_MOUSE (Q00993) Tyrosine-protein kinase receptor UFO precursor (EC| 2.7.10.1) (Adhesion-related kinase) Length = 888 Score = 39.3 bits (90), Expect = 0.010 Identities = 31/138 (22%), Positives = 58/138 (42%), Gaps = 1/138 (0%) Frame = +2 Query: 146 DSRTGMLNHPSHRGPVAVVSYSVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKD-Y 322 ++R G + P+ VV Y V S R +A +++ +E LK+ Sbjct: 472 ETRYGEVFEPTVERGELVVRYRVRKSYSR-----------RTTEATLNSLGISEELKEKL 520 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEV 502 + +D K+ +G +G FG + G N D +K+ + + + F+ E Sbjct: 521 RDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEA 580 Query: 503 RMLAELRHPNIVKFVGAC 556 + E HPN+++ +G C Sbjct: 581 VCMKEFDHPNVMRLIGVC 598
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 39.3 bits (90), Expect = 0.010 Identities = 29/101 (28%), Positives = 49/101 (48%), Gaps = 11/101 (10%) Frame = +2 Query: 335 IDLGKLHMGLPFAQGAFGKLYRGTY--NGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 I + +G +GAFG +YRG NG VA+K ++ + +++ E+ + Sbjct: 4 IQASSITLGDCLGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKM----EIDL 59 Query: 509 LAELRHPNIVKFVGACRKP----IVLVHCHR-----VCKGW 604 L L HPNIVK+ G+ + I+L +C +CK + Sbjct: 60 LKNLDHPNIVKYRGSYQTNDSLCIILEYCENGSLRSICKNF 100
>ROR2_MOUSE (Q9Z138) Tyrosine-protein kinase transmembrane receptor ROR2| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2) Length = 944 Score = 39.3 bits (90), Expect = 0.010 Identities = 31/99 (31%), Positives = 41/99 (41%), Gaps = 7/99 (7%) Frame = +2 Query: 335 IDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEADPPQAQLLEQQFV 493 I L + + FGK+Y+G G VAIK L+ P L ++F Sbjct: 468 ISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGP-----LREEFR 522 Query: 494 QEVRMLAELRHPNIVKFVGACRKPIVLVHCHRVCKGWDL 610 QE + A L+HPNIV +G K L C DL Sbjct: 523 QEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDL 561
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 39.3 bits (90), Expect = 0.010 Identities = 23/71 (32%), Positives = 41/71 (57%), Gaps = 3/71 (4%) Frame = +2 Query: 374 QGAFGKLYRGT-YNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 +GAFGK++ YN ++ K+L +A ++ Q F +E +L L+H +IV+F G Sbjct: 521 EGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFG 580 Query: 551 ACRK--PIVLV 577 C + P+++V Sbjct: 581 VCTEGGPLLMV 591
>PGFRA_XENLA (P26619) Alpha platelet-derived growth factor receptor precursor| (EC 2.7.10.1) (PDGF-R-alpha) Length = 1087 Score = 39.3 bits (90), Expect = 0.010 Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 11/124 (8%) Frame = +2 Query: 239 RVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG- 415 RV ++S D +D P + D W L +G GAFGK+ G G Sbjct: 562 RVIESISPDGHEYIYVD---PMQLPYD-SRWEFPRDGLVLGRILGSGAFGKVVEGAAYGL 617 Query: 416 ------MDVAIKLLERPEADPPQAQLLEQQ-FVQEVRMLAEL-RHPNIVKFVGACRK--P 565 M VA+K+L+ P A+ E+Q + E++++ L H NIV +GAC K P Sbjct: 618 SRSQPVMKVAVKMLK------PTARSSEKQALMSELKIMTHLGAHLNIVNLLGACTKSGP 671 Query: 566 IVLV 577 I ++ Sbjct: 672 IYII 675
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 39.3 bits (90), Expect = 0.010 Identities = 24/66 (36%), Positives = 39/66 (59%), Gaps = 4/66 (6%) Frame = +2 Query: 377 GAFGKLYRGTY--NGMDVAIK--LLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKF 544 GAFG++Y G +G +AIK L+ A + Q ++ +EV++L L HPNIV++ Sbjct: 77 GAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPNIVRY 136 Query: 545 VGACRK 562 +G R+ Sbjct: 137 LGTVRE 142
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) Length = 813 Score = 39.3 bits (90), Expect = 0.010 Identities = 26/100 (26%), Positives = 47/100 (47%), Gaps = 14/100 (14%) Frame = +2 Query: 299 PTETLKDYE-----EWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD---------VAIKL 436 P + +YE W KL +G P +G FG++ G+D VA+K+ Sbjct: 449 PLANVSEYELPHDPMWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKERPKESVTVAVKM 508 Query: 437 LERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGAC 556 L+ + A L+ + ++ ++M+ +H NI+ +GAC Sbjct: 509 LKDNATEKDLADLVSE--MEMMKMIG--KHKNIINLLGAC 544
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 39.3 bits (90), Expect = 0.010 Identities = 25/92 (27%), Positives = 47/92 (51%), Gaps = 2/92 (2%) Frame = +2 Query: 308 TLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQ 484 ++K + W I L + G FG+++ GT+NG VAIK L+ P + Sbjct: 256 SVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSP-------E 308 Query: 485 QFVQEVRMLAELRHPNIVK-FVGACRKPIVLV 577 F++E +++ +L+H +V+ + +PI +V Sbjct: 309 SFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIV 340
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 39.3 bits (90), Expect = 0.010 Identities = 25/92 (27%), Positives = 47/92 (51%), Gaps = 2/92 (2%) Frame = +2 Query: 308 TLKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQ 484 ++K + W I L + G FG+++ GT+NG VAIK L+ P + Sbjct: 256 SVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSP-------E 308 Query: 485 QFVQEVRMLAELRHPNIVK-FVGACRKPIVLV 577 F++E +++ +L+H +V+ + +PI +V Sbjct: 309 SFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIV 340
>FAK1_MOUSE (P34152) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1090 Score = 38.9 bits (89), Expect = 0.013 Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 5/84 (5%) Frame = +2 Query: 314 KDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTY-----NGMDVAIKLLERPEADPPQAQLL 478 +DYE I ++ +G +G FG +++G Y + VAIK + +D + Sbjct: 451 RDYE---IQRERIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSDS-----V 502 Query: 479 EQQFVQEVRMLAELRHPNIVKFVG 550 ++F+QE + + HP+IVK +G Sbjct: 503 REKFLQEALTMRQFDHPHIVKLIG 526
>MUSK_RAT (Q62838) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 38.9 bits (89), Expect = 0.013 Identities = 25/77 (32%), Positives = 42/77 (54%), Gaps = 9/77 (11%) Frame = +2 Query: 374 QGAFGKLYRGTYNGM-------DVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPN 532 +GAFG++++ G+ VA+K+L+ + QA F +E ++AE +PN Sbjct: 582 EGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQAD-----FQREAALMAEFDNPN 636 Query: 533 IVKFVGACR--KPIVLV 577 IVK +G C KP+ L+ Sbjct: 637 IVKLLGVCAVGKPMCLL 653
>MUSK_MOUSE (Q61006) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 38.9 bits (89), Expect = 0.013 Identities = 25/77 (32%), Positives = 42/77 (54%), Gaps = 9/77 (11%) Frame = +2 Query: 374 QGAFGKLYRGTYNGM-------DVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPN 532 +GAFG++++ G+ VA+K+L+ + QA F +E ++AE +PN Sbjct: 582 EGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQAD-----FQREAALMAEFDNPN 636 Query: 533 IVKFVGACR--KPIVLV 577 IVK +G C KP+ L+ Sbjct: 637 IVKLLGVCAVGKPMCLL 653
>KFMS_FSVMD (P00545) Tyrosine-protein kinase transforming protein fms (EC| 2.7.10.1) Length = 978 Score = 38.9 bits (89), Expect = 0.013 Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 10/107 (9%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLE-RPEADPPQAQLL 478 E+W L G GAFGK+ T G + VA+K+L+ AD +A Sbjct: 604 EKWEFPRNNLQFGKTLGTGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA--- 660 Query: 479 EQQFVQEVRMLAEL-RHPNIVKFVGAC-RKPIVLVHCHRVCKGWDLL 613 + E+++++ L +H NIV +GAC VLV C G DLL Sbjct: 661 ---LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYG-DLL 703
>CSF1R_RAT (Q00495) Macrophage colony-stimulating factor 1 receptor precursor| (CSF-1-R) (EC 2.7.10.1) (Fms proto-oncogene) (c-fms) Length = 978 Score = 38.9 bits (89), Expect = 0.013 Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 10/107 (9%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLE-RPEADPPQAQLL 478 E+W L G GAFGK+ T G + VA+K+L+ AD +A Sbjct: 571 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA--- 627 Query: 479 EQQFVQEVRMLAEL-RHPNIVKFVGAC-RKPIVLVHCHRVCKGWDLL 613 + E+++++ L +H NIV +GAC VLV C G DLL Sbjct: 628 ---LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYG-DLL 670
>CSF1R_HUMAN (P07333) Macrophage colony-stimulating factor 1 receptor precursor| (CSF-1-R) (EC 2.7.10.1) (Fms proto-oncogene) (c-fms) (CD115 antigen) Length = 972 Score = 38.9 bits (89), Expect = 0.013 Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 10/107 (9%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLE-RPEADPPQAQLL 478 E+W L G GAFGK+ T G + VA+K+L+ AD +A Sbjct: 573 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA--- 629 Query: 479 EQQFVQEVRMLAEL-RHPNIVKFVGAC-RKPIVLVHCHRVCKGWDLL 613 + E+++++ L +H NIV +GAC VLV C G DLL Sbjct: 630 ---LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYG-DLL 672
>MARK3_RAT (Q8VHF0) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| Length = 797 Score = 38.9 bits (89), Expect = 0.013 Identities = 21/51 (41%), Positives = 31/51 (60%) Frame = +2 Query: 389 KLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVK 541 KL R G +VAIK++++ + +P Q L +EVR++ L HPNIVK Sbjct: 71 KLARHILTGREVAIKIIDKTQLNPTSLQKL----FREVRIMKILNHPNIVK 117
>KIN31_CAEEL (P34265) Probable tyrosine-protein kinase kin-31 (EC 2.7.10.2)| Length = 437 Score = 38.9 bits (89), Expect = 0.013 Identities = 26/91 (28%), Positives = 44/91 (48%), Gaps = 8/91 (8%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNG------MDVAIKLLERPEADPPQAQLLEQQF 490 W +D G + + +GAFG++ G + VA+K ++ Q + F Sbjct: 123 WELDHGNIVIEKKLGEGAFGEVSSGVMKFKRGGRLVKVAVKQVKTDGIGKDQIK----DF 178 Query: 491 VQEVRMLAELRHPNIVKFVG--ACRKPIVLV 577 + E R + L HPNIV+F+G ++P+ LV Sbjct: 179 LMEARTMRNLGHPNIVRFLGIAVLQEPLFLV 209
>CSF1R_FELCA (P13369) Macrophage colony-stimulating factor 1 receptor precursor| (CSF-1-R) (EC 2.7.10.1) (Fms proto-oncogene) (c-fms) Length = 980 Score = 38.9 bits (89), Expect = 0.013 Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 10/107 (9%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLE-RPEADPPQAQLL 478 E+W L G GAFGK+ T G + VA+K+L+ AD +A Sbjct: 570 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA--- 626 Query: 479 EQQFVQEVRMLAEL-RHPNIVKFVGAC-RKPIVLVHCHRVCKGWDLL 613 + E+++++ L +H NIV +GAC VLV C G DLL Sbjct: 627 ---LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYG-DLL 669
>MUSK_CHICK (Q8AXY6) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 947 Score = 38.9 bits (89), Expect = 0.013 Identities = 25/77 (32%), Positives = 42/77 (54%), Gaps = 9/77 (11%) Frame = +2 Query: 374 QGAFGKLYRGTYNGM-------DVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPN 532 +GAFG++++ G+ VA+K+L+ + QA F +E ++AE +PN Sbjct: 663 EGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQAD-----FQREAALMAEFDNPN 717 Query: 533 IVKFVGACR--KPIVLV 577 IVK +G C KP+ L+ Sbjct: 718 IVKLLGVCAVGKPMCLL 734
>FGFR1_RAT (Q04589) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 38.9 bits (89), Expect = 0.013 Identities = 29/127 (22%), Positives = 58/127 (45%), Gaps = 9/127 (7%) Frame = +2 Query: 203 SYSVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGA 382 S + G + RP R+S S + + + P + W + +L +G P +G Sbjct: 436 SMNSGVLLVRPSRLSS--SGTPMLAGVSEYELPEDP-----RWELPRDRLVLGKPLGEGC 488 Query: 383 FGKLYRGTYNGMD---------VAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNI 535 FG++ G+D VA+K+L+ + + L+ + ++ ++M+ +H NI Sbjct: 489 FGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE--MEMMKMIG--KHKNI 544 Query: 536 VKFVGAC 556 + +GAC Sbjct: 545 INLLGAC 551
>FGFR1_MOUSE (P16092) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 38.9 bits (89), Expect = 0.013 Identities = 29/127 (22%), Positives = 58/127 (45%), Gaps = 9/127 (7%) Frame = +2 Query: 203 SYSVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGA 382 S + G + RP R+S S + + + P + W + +L +G P +G Sbjct: 436 SMNSGVLLVRPSRLSS--SGTPMLAGVSEYELPEDP-----RWELPRDRLVLGKPLGEGC 488 Query: 383 FGKLYRGTYNGMD---------VAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNI 535 FG++ G+D VA+K+L+ + + L+ + ++ ++M+ +H NI Sbjct: 489 FGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE--MEMMKMIG--KHKNI 544 Query: 536 VKFVGAC 556 + +GAC Sbjct: 545 INLLGAC 551
>FGFR1_HUMAN (P11362) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 38.9 bits (89), Expect = 0.013 Identities = 29/127 (22%), Positives = 58/127 (45%), Gaps = 9/127 (7%) Frame = +2 Query: 203 SYSVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTIDLGKLHMGLPFAQGA 382 S + G + RP R+S S + + + P + W + +L +G P +G Sbjct: 436 SMNSGVLLVRPSRLSS--SGTPMLAGVSEYELPEDP-----RWELPRDRLVLGKPLGEGC 488 Query: 383 FGKLYRGTYNGMD---------VAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNI 535 FG++ G+D VA+K+L+ + + L+ + ++ ++M+ +H NI Sbjct: 489 FGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE--MEMMKMIG--KHKNI 544 Query: 536 VKFVGAC 556 + +GAC Sbjct: 545 INLLGAC 551
>MARK3_MOUSE (Q03141) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (MPK-10) (ELKL motif kinase 2) Length = 753 Score = 38.9 bits (89), Expect = 0.013 Identities = 21/51 (41%), Positives = 31/51 (60%) Frame = +2 Query: 389 KLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVK 541 KL R G +VAIK++++ + +P Q L +EVR++ L HPNIVK Sbjct: 71 KLARHILTGREVAIKIIDKTQLNPTSLQKL----FREVRIMKILNHPNIVK 117
>FGFR3_MOUSE (Q61851) Fibroblast growth factor receptor 3 precursor (EC| 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) Length = 801 Score = 38.9 bits (89), Expect = 0.013 Identities = 22/86 (25%), Positives = 44/86 (51%), Gaps = 9/86 (10%) Frame = +2 Query: 326 EWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD---------VAIKLLERPEADPPQAQLL 478 +W + +L +G P +G FG++ G+D VA+K+L+ D + L+ Sbjct: 458 KWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLV 517 Query: 479 EQQFVQEVRMLAELRHPNIVKFVGAC 556 + ++ ++M+ +H NI+ +GAC Sbjct: 518 SE--MEMMKMIG--KHKNIINLLGAC 539
>MUSK_HUMAN (O15146) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 869 Score = 38.9 bits (89), Expect = 0.013 Identities = 25/77 (32%), Positives = 42/77 (54%), Gaps = 9/77 (11%) Frame = +2 Query: 374 QGAFGKLYRGTYNGM-------DVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPN 532 +GAFG++++ G+ VA+K+L+ + QA F +E ++AE +PN Sbjct: 583 EGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQAD-----FQREAALMAEFDNPN 637 Query: 533 IVKFVGACR--KPIVLV 577 IVK +G C KP+ L+ Sbjct: 638 IVKLLGVCAVGKPMCLL 654
>MARK3_HUMAN (P27448) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10) Length = 776 Score = 38.9 bits (89), Expect = 0.013 Identities = 21/51 (41%), Positives = 31/51 (60%) Frame = +2 Query: 389 KLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVK 541 KL R G +VAIK++++ + +P Q L +EVR++ L HPNIVK Sbjct: 71 KLARHILTGREVAIKIIDKTQLNPTSLQKL----FREVRIMKILNHPNIVK 117
>CSF1R_MOUSE (P09581) Macrophage colony-stimulating factor 1 receptor precursor| (CSF-1-R) (EC 2.7.10.1) (Fms proto-oncogene) (c-fms) Length = 977 Score = 38.9 bits (89), Expect = 0.013 Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 10/107 (9%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLE-RPEADPPQAQLL 478 E+W L G GAFGK+ T G + VA+K+L+ AD +A Sbjct: 571 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA--- 627 Query: 479 EQQFVQEVRMLAEL-RHPNIVKFVGAC-RKPIVLVHCHRVCKGWDLL 613 + E+++++ L +H NIV +GAC VLV C G DLL Sbjct: 628 ---LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYG-DLL 670
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) Length = 812 Score = 38.9 bits (89), Expect = 0.013 Identities = 24/96 (25%), Positives = 48/96 (50%), Gaps = 14/96 (14%) Frame = +2 Query: 311 LKDYE-----EWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD---------VAIKLLERP 448 L +YE W + +L +G P +G FG++ G+D VA+K+L+ Sbjct: 454 LSEYELPEDPRWEVARDRLILGKPLGEGCFGQVVMAEAIGLDKEKPNKVTKVAVKMLKSD 513 Query: 449 EADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVGAC 556 ++ + L+ + ++ ++M+ +H NI+ +GAC Sbjct: 514 ASEKDLSDLISE--MEMMKMIG--KHKNIINLLGAC 545
>LTK_HUMAN (P29376) Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1)| (Protein tyrosine kinase 1) Length = 864 Score = 38.9 bits (89), Expect = 0.013 Identities = 26/65 (40%), Positives = 36/65 (55%), Gaps = 7/65 (10%) Frame = +2 Query: 377 GAFGKLYRGTYNGM-------DVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNI 535 GAFG++Y G G+ VAIK L PE PQ +L F+ E ++++ RH NI Sbjct: 519 GAFGEVYEGLVIGLPGDSSPLQVAIKTL--PELCSPQDEL---DFLMEALIISKFRHQNI 573 Query: 536 VKFVG 550 V+ VG Sbjct: 574 VRCVG 578
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 38.9 bits (89), Expect = 0.013 Identities = 20/65 (30%), Positives = 38/65 (58%), Gaps = 1/65 (1%) Frame = +2 Query: 374 QGAFGKLYRGTYN-GMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 +G FG ++R + +VA K+L+ +A+ ++FV E +++ +LRH IV+ +G Sbjct: 228 RGFFGSVHRAKWGRSYEVAAKMLQSSKAE-------REKFVLEAKIMHKLRHRKIVELLG 280 Query: 551 ACRKP 565 C +P Sbjct: 281 VCTEP 285
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 38.9 bits (89), Expect = 0.013 Identities = 22/91 (24%), Positives = 43/91 (47%), Gaps = 3/91 (3%) Frame = +2 Query: 314 KDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTY-NGMDVAIKLLERPEADPPQAQLLEQQF 490 K + W I + + G FG++Y+G + N VA+K L+ P F Sbjct: 83 KTKDMWEISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTLKAGTMQP-------AAF 135 Query: 491 VQEVRMLAELRHPNIVKFVGACR--KPIVLV 577 + E +++ +LRHP +++ C +P+ ++ Sbjct: 136 LAEAQIMKKLRHPKLIQLYAVCTQGEPVYII 166
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 38.5 bits (88), Expect = 0.016 Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 3/88 (3%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQFVQE 499 + W I L + G FG+++ G +N VA+K L+ P F+ E Sbjct: 231 DAWEIPRESLRLNRKLGAGQFGEVWAGVWNNTTQVAVKTLKPGTMSP-------ASFLDE 283 Query: 500 VRMLAELRHPNIVKFVGAC--RKPIVLV 577 ++ +LRH ++V+ C R+PI +V Sbjct: 284 AGVMKKLRHKHLVQLYAICSDREPIYIV 311
>CDKL4_HUMAN (Q5MAI5) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 315 Score = 38.5 bits (88), Expect = 0.016 Identities = 20/65 (30%), Positives = 39/65 (60%), Gaps = 2/65 (3%) Frame = +2 Query: 374 QGAFGKLY--RGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFV 547 +G++G ++ R +G VA+K E DP ++++ ++E+RML +L+HPN+V + Sbjct: 12 EGSYGVVFKCRNKTSGQVVAVKKFVESEDDP----VVKKIALREIRMLKQLKHPNLVNLI 67 Query: 548 GACRK 562 R+ Sbjct: 68 EVFRR 72
>PGFRB_CANFA (Q6QNF3) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) Length = 1103 Score = 38.5 bits (88), Expect = 0.016 Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 8/103 (7%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEADPPQAQLLEQQ 487 W + +L +G GAFG++ T +G M VA+K+L+ +Q Sbjct: 593 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSE-----KQA 647 Query: 488 FVQEVRMLAEL-RHPNIVKFVGACRKPIVLVHCHRVCKGWDLL 613 + E+++++ L H N+V +GAC K + C+ DL+ Sbjct: 648 LMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLV 690
>PGFRB_RAT (Q05030) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) Length = 1097 Score = 38.5 bits (88), Expect = 0.016 Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 8/103 (7%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEADPPQAQLLEQQ 487 W + +L +G GAFG++ T +G M VA+K+L+ +Q Sbjct: 592 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSE-----KQA 646 Query: 488 FVQEVRMLAEL-RHPNIVKFVGACRKPIVLVHCHRVCKGWDLL 613 + E+++++ L H N+V +GAC K + C+ DL+ Sbjct: 647 LMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLV 689
>PGFRB_MOUSE (P05622) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) Length = 1098 Score = 38.5 bits (88), Expect = 0.016 Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 8/103 (7%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEADPPQAQLLEQQ 487 W + +L +G GAFG++ T +G M VA+K+L+ +Q Sbjct: 592 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSE-----KQA 646 Query: 488 FVQEVRMLAEL-RHPNIVKFVGACRKPIVLVHCHRVCKGWDLL 613 + E+++++ L H N+V +GAC K + C+ DL+ Sbjct: 647 LMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLV 689
>MOS_NYCNY (Q90XV9) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 38.5 bits (88), Expect = 0.016 Identities = 20/63 (31%), Positives = 34/63 (53%) Frame = +2 Query: 365 PFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKF 544 P G FG +Y+ TY+G VA+K +++ + +L +Q +A L+H N+V+ Sbjct: 7 PLGSGGFGSVYKATYHGATVAVKQVKKSSKN----RLASRQSFWAELNVAWLQHDNVVRV 62 Query: 545 VGA 553 V A Sbjct: 63 VAA 65
>MOS_CICNG (Q90XV8) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 38.5 bits (88), Expect = 0.016 Identities = 20/63 (31%), Positives = 33/63 (52%) Frame = +2 Query: 365 PFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKF 544 P G FG +Y+ TY+G VA+K ++ + +L +Q +A L+H N+V+ Sbjct: 7 PLGSGGFGSVYKATYHGATVAVKQVKNSSKN----RLASRQSFWAELNVARLQHNNVVRV 62 Query: 545 VGA 553 V A Sbjct: 63 VAA 65
>ILK1_HUMAN (Q13418) Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59| kDa serine/threonine-protein kinase) (p59ILK) Length = 452 Score = 38.5 bits (88), Expect = 0.016 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 9/80 (11%) Frame = +2 Query: 353 HMGLPFAQGAF---------GKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVR 505 H G+ F Q F G+L++G + G D+ +K+L+ + +++ F +E Sbjct: 185 HSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSR----DFNEECP 240 Query: 506 MLAELRHPNIVKFVGACRKP 565 L HPN++ +GAC+ P Sbjct: 241 RLRIFSHPNVLPVLGACQSP 260
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 38.5 bits (88), Expect = 0.016 Identities = 26/82 (31%), Positives = 41/82 (50%), Gaps = 7/82 (8%) Frame = +2 Query: 332 TIDLGKLHMGLPFAQGAFGKLYRGTYNGMD-------VAIKLLERPEADPPQAQLLEQQF 490 T+ L + + +GAFG+++ GT + VA+K L+ +D L++ F Sbjct: 498 TVRLQTILLMRVIGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGSCSDS-----LKRDF 552 Query: 491 VQEVRMLAELRHPNIVKFVGAC 556 +E MLA + H NIV F G C Sbjct: 553 EREAEMLATIEHANIVTFYGVC 574
>PGFRB_HUMAN (P09619) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) (CD140b antigen) Length = 1106 Score = 38.5 bits (88), Expect = 0.016 Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 8/103 (7%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTYNG-------MDVAIKLLERPEADPPQAQLLEQQ 487 W + +L +G GAFG++ T +G M VA+K+L+ +Q Sbjct: 593 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSE-----KQA 647 Query: 488 FVQEVRMLAEL-RHPNIVKFVGACRKPIVLVHCHRVCKGWDLL 613 + E+++++ L H N+V +GAC K + C+ DL+ Sbjct: 648 LMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLV 690
>ROR1_MOUSE (Q9Z139) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1) Length = 937 Score = 38.5 bits (88), Expect = 0.016 Identities = 28/63 (44%), Positives = 37/63 (58%), Gaps = 6/63 (9%) Frame = +2 Query: 383 FGKLYRGTYN--GMD----VAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKF 544 FGK+Y+G GMD VAIK L+ + + PQ +F QE ++AEL HPNIV Sbjct: 484 FGKIYKGHLYLPGMDHAQLVAIKTLK--DYNNPQQWT---EFQQEASLMAELHHPNIVCL 538 Query: 545 VGA 553 +GA Sbjct: 539 LGA 541
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 38.5 bits (88), Expect = 0.016 Identities = 23/77 (29%), Positives = 42/77 (54%), Gaps = 2/77 (2%) Frame = +2 Query: 326 EWTIDLGKLHMGLPFAQGAFGKLY--RGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQE 499 +WT++ +G P +G FG +Y R + +A+K+L + + + +E Q +E Sbjct: 120 QWTLE--DFDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKVQLEKAG---VEHQLRRE 174 Query: 500 VRMLAELRHPNIVKFVG 550 V + + LRHPNI++ G Sbjct: 175 VEIQSHLRHPNILRLYG 191
>ILK_CAVPO (P57044) Integrin-linked protein kinase (EC 2.7.11.1)| (Beta-integrin-linked kinase) Length = 451 Score = 38.5 bits (88), Expect = 0.016 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 9/80 (11%) Frame = +2 Query: 353 HMGLPFAQGAF---------GKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVR 505 H G+ F Q F G+L++G + G D+ +K+L+ + +++ F +E Sbjct: 185 HSGIDFKQLNFLAKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSR----DFNEECP 240 Query: 506 MLAELRHPNIVKFVGACRKP 565 L HPN++ +GAC+ P Sbjct: 241 RLRIFSHPNVLPVLGACQSP 260
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 38.1 bits (87), Expect = 0.021 Identities = 28/125 (22%), Positives = 57/125 (45%), Gaps = 4/125 (3%) Frame = +2 Query: 188 PVAVVSYSVGNSIFRPGRVSHALSDDALAQA--LMDTRFPTETLKDYEEWTIDLGKLHMG 361 P +S + + +RP ++ + ++ D P + + +++D +G Sbjct: 45 PTGRISTTQPQTYYRPTNLTKTPASQVSRRSSYTTDPPSPLTGITGFRNYSLD--DFEIG 102 Query: 362 LPFAQGAFGKLY--RGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNI 535 +G FGK+Y + G A+K +E+ E +E+QF +EV + + LRH N+ Sbjct: 103 KALGKGKFGKVYLVKDKKTGFVSALKCMEKKELVEGN---VEKQFRREVEIQSNLRHTNV 159 Query: 536 VKFVG 550 ++ G Sbjct: 160 LRLFG 164
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 38.1 bits (87), Expect = 0.021 Identities = 24/73 (32%), Positives = 39/73 (53%) Frame = +2 Query: 335 IDLGKLHMGLPFAQGAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLA 514 ID G++ + G FG +Y+ TY+G+ VAIK + + +Q + F E+ +A Sbjct: 56 IDWGQVCLLHRLGSGGFGSVYKATYHGVPVAIKQVNKCTRTLRASQ---RNFWAELN-IA 111 Query: 515 ELRHPNIVKFVGA 553 L H NI++ V A Sbjct: 112 RLHHDNIIRVVAA 124
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 38.1 bits (87), Expect = 0.021 Identities = 22/74 (29%), Positives = 39/74 (52%), Gaps = 2/74 (2%) Frame = +2 Query: 335 IDLGKLHMGLPFAQGAFGKLY--RGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRM 508 + L +G +G FG++Y R +G A+K +E+ + +E+QF +EV + Sbjct: 104 LKLADFEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYN---IEKQFRREVEI 160 Query: 509 LAELRHPNIVKFVG 550 + LRHPN+ + G Sbjct: 161 QSSLRHPNLTQLYG 174
>XMRK_XIPMA (P13388) Melanoma receptor tyrosine-protein kinase precursor (EC| 2.7.10.1) Length = 1167 Score = 38.1 bits (87), Expect = 0.021 Identities = 22/66 (33%), Positives = 38/66 (57%), Gaps = 6/66 (9%) Frame = +2 Query: 377 GAFGKLYRGTYNG------MDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIV 538 GAFG +Y+G +N + VAIK+L EA P+ + Q+ + E ++A + HP++ Sbjct: 719 GAFGTVYKGLWNPDGENIRIPVAIKVLR--EATSPK---VNQEVLDEAYVMASVDHPHVC 773 Query: 539 KFVGAC 556 + +G C Sbjct: 774 RLLGIC 779
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 38.1 bits (87), Expect = 0.021 Identities = 23/91 (25%), Positives = 45/91 (49%), Gaps = 9/91 (9%) Frame = +2 Query: 311 LKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD---------VAIKLLERPEADPP 463 L + +W KL +G P +G FG++ G+D VA+K+L+ + Sbjct: 470 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKD 529 Query: 464 QAQLLEQQFVQEVRMLAELRHPNIVKFVGAC 556 + L+ + ++ ++M+ +H NI+ +GAC Sbjct: 530 LSDLVSE--MEMMKMIG--KHKNIINLLGAC 556
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 38.1 bits (87), Expect = 0.021 Identities = 22/71 (30%), Positives = 40/71 (56%), Gaps = 3/71 (4%) Frame = +2 Query: 374 QGAFGKLYRGT-YNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 +GAFGK++ +N + K+L +A ++ Q F +E +L L+H +IV+F G Sbjct: 518 EGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFG 577 Query: 551 ACR--KPIVLV 577 C +P+++V Sbjct: 578 VCTEGRPLLMV 588
>ILK_MOUSE (O55222) Integrin-linked protein kinase (EC 2.7.11.1)| Length = 452 Score = 38.1 bits (87), Expect = 0.021 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 9/80 (11%) Frame = +2 Query: 353 HMGLPFAQGAF---------GKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVR 505 H G+ F Q F G+L++G + G D+ +K+L+ + +++ F +E Sbjct: 185 HSGIDFKQLNFLAKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSR----DFNEECP 240 Query: 506 MLAELRHPNIVKFVGACRKP 565 L HPN++ +GAC+ P Sbjct: 241 RLRIFSHPNVLPVLGACQAP 260
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 38.1 bits (87), Expect = 0.021 Identities = 23/87 (26%), Positives = 44/87 (50%), Gaps = 2/87 (2%) Frame = +2 Query: 323 EEWTIDLGKLHMGLPFAQGAFGKLYRGTYNG-MDVAIKLLERPEADPPQAQLLEQQFVQE 499 + W + L + QG F +++ GT+NG VAIK L+ P + F++E Sbjct: 258 DAWEVARDSLFLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSP-------ESFLEE 310 Query: 500 VRMLAELRHPNIVK-FVGACRKPIVLV 577 +++ +L+H +V+ + +PI +V Sbjct: 311 AQIMKKLKHDKLVQLYAVVSEEPIYIV 337
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 38.1 bits (87), Expect = 0.021 Identities = 23/91 (25%), Positives = 45/91 (49%), Gaps = 9/91 (9%) Frame = +2 Query: 311 LKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD---------VAIKLLERPEADPP 463 L + +W KL +G P +G FG++ G+D VA+K+L+ + Sbjct: 468 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 527 Query: 464 QAQLLEQQFVQEVRMLAELRHPNIVKFVGAC 556 + L+ + ++ ++M+ +H NI+ +GAC Sbjct: 528 LSDLVSE--MEMMKMIG--KHKNIINLLGAC 554
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 38.1 bits (87), Expect = 0.021 Identities = 23/91 (25%), Positives = 45/91 (49%), Gaps = 9/91 (9%) Frame = +2 Query: 311 LKDYEEWTIDLGKLHMGLPFAQGAFGKLYRGTYNGMD---------VAIKLLERPEADPP 463 L + +W KL +G P +G FG++ G+D VA+K+L+ + Sbjct: 468 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 527 Query: 464 QAQLLEQQFVQEVRMLAELRHPNIVKFVGAC 556 + L+ + ++ ++M+ +H NI+ +GAC Sbjct: 528 LSDLVSE--MEMMKMIG--KHKNIINLLGAC 554
>WNK4_HUMAN (Q96J92) Serine/threonine-protein kinase WNK4 (EC 2.7.11.1)| (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1243 Score = 38.1 bits (87), Expect = 0.021 Identities = 33/116 (28%), Positives = 51/116 (43%), Gaps = 4/116 (3%) Frame = +2 Query: 209 SVGNSIFRPGRVSHALSDDALAQALMDTRFPTETLKDYEEWTI----DLGKLHMGLPFAQ 376 +VG P RV A++ ++ R E +D E + D L + + Sbjct: 131 AVGPGSREPLRVPEAVA--------LERRREQEEKEDMETQAVATSPDGRYLKFDIEIGR 182 Query: 377 GAFGKLYRGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKF 544 G+F +YRG V + E +A+ Q+F +EV ML L+HPNIV+F Sbjct: 183 GSFKTVYRGLDTDTTVEVAWCELQTRKLSRAE--RQRFSEEVEMLKGLQHPNIVRF 236
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 38.1 bits (87), Expect = 0.021 Identities = 19/64 (29%), Positives = 35/64 (54%), Gaps = 1/64 (1%) Frame = +2 Query: 374 QGAFGKLYRGTYN-GMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 +G FG +YRGT + G +VA+K+ + +F E+ +L+ ++H N+V +G Sbjct: 603 EGGFGSVYRGTLDDGQEVAVKVRSATSTQGTR------EFDNELNLLSAIQHENLVPLLG 656 Query: 551 ACRK 562 C + Sbjct: 657 YCNE 660
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does| not make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 38.1 bits (87), Expect = 0.021 Identities = 19/64 (29%), Positives = 35/64 (54%), Gaps = 1/64 (1%) Frame = +2 Query: 374 QGAFGKLYRGTYN-GMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 +G FG +YRGT + G +VA+K+ + +F E+ +L+ ++H N+V +G Sbjct: 604 EGGFGSVYRGTLDDGQEVAVKVRSSTSTQGTR------EFDNELNLLSAIQHENLVPLLG 657 Query: 551 ACRK 562 C + Sbjct: 658 YCNE 661
>CDKL1_BRARE (Q6AXJ9) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 350 Score = 38.1 bits (87), Expect = 0.021 Identities = 21/65 (32%), Positives = 38/65 (58%), Gaps = 2/65 (3%) Frame = +2 Query: 374 QGAFGKLY--RGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFV 547 +G++G ++ R G VAIK E DP ++++ ++E+RML +L+HPN+V + Sbjct: 12 EGSYGVVFKCRNKDTGQIVAIKKFVESEDDP----IIKKIALREIRMLKQLKHPNLVNLM 67 Query: 548 GACRK 562 R+ Sbjct: 68 EVFRR 72
>CIPK1_ARATH (Q8RWC9) CBL-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (SOS2-like protein kinase PKS13) (SNF1-related kinase 3.16) Length = 444 Score = 37.7 bits (86), Expect = 0.028 Identities = 22/69 (31%), Positives = 37/69 (53%), Gaps = 2/69 (2%) Frame = +2 Query: 341 LGKLHMGLPFAQGAFGKLY--RGTYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLA 514 LGK +G +G FGK+ + T +G A+K++++ L Q +E+R L Sbjct: 17 LGKYELGRTLGEGNFGKVKFAKDTVSGHSFAVKIIDKSRIADLNFSL---QIKREIRTLK 73 Query: 515 ELRHPNIVK 541 L+HP+IV+ Sbjct: 74 MLKHPHIVR 82
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 37.7 bits (86), Expect = 0.028 Identities = 27/77 (35%), Positives = 41/77 (53%), Gaps = 9/77 (11%) Frame = +2 Query: 374 QGAFGKLYRG-------TYNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPN 532 +GAFGK++ T + M VA+K L+ DP A + F +E +L L+H + Sbjct: 548 EGAFGKVFLAECYNLSPTNDKMLVAVKALK----DPTLAA--RKDFQREAELLTNLQHEH 601 Query: 533 IVKFVGAC--RKPIVLV 577 IVKF G C P+++V Sbjct: 602 IVKFYGVCGDGDPLIMV 618
>EGL15_CAEEL (Q10656) Myoblast growth factor receptor egl-15 precursor (EC| 2.7.10.1) (Egg-laying defective protein 15) Length = 1040 Score = 37.7 bits (86), Expect = 0.028 Identities = 24/99 (24%), Positives = 49/99 (49%), Gaps = 5/99 (5%) Frame = +2 Query: 329 WTIDLGKLHMGLPFAQGAFGKLYRGTY-----NGMDVAIKLLERPEADPPQAQLLEQQFV 493 W ++ KL + +GAFG++++ TY N + VA+K L+ + L+ + + Sbjct: 633 WEVERSKLSLVHMLGEGAFGEVWKATYKETENNEIAVAVKKLKMSAHEKELIDLVSE--M 690 Query: 494 QEVRMLAELRHPNIVKFVGACRKPIVLVHCHRVCKGWDL 610 + +++ E H N+++ +G C L +CK +L Sbjct: 691 ETFKVIGE--HENVLRLIGCCTGAGPLYVVVELCKHGNL 727
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 37.7 bits (86), Expect = 0.028 Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 3/71 (4%) Frame = +2 Query: 374 QGAFGKLYRGT-YNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 +GAFGK++ YN K+L +A + F +E +L L+H +IVKF G Sbjct: 546 EGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYG 605 Query: 551 AC--RKPIVLV 577 C P+++V Sbjct: 606 VCGDGDPLIMV 616
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 37.7 bits (86), Expect = 0.028 Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 3/71 (4%) Frame = +2 Query: 374 QGAFGKLYRGT-YNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 +GAFGK++ YN K+L +A + F +E +L L+H +IVKF G Sbjct: 546 EGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYG 605 Query: 551 AC--RKPIVLV 577 C P+++V Sbjct: 606 VCGDGDPLIMV 616
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 37.7 bits (86), Expect = 0.028 Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 3/71 (4%) Frame = +2 Query: 374 QGAFGKLYRGT-YNGMDVAIKLLERPEADPPQAQLLEQQFVQEVRMLAELRHPNIVKFVG 550 +GAFGK++ YN K+L +A + F +E +L L+H +IVKF G Sbjct: 546 EGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYG 605 Query: 551 AC--RKPIVLV 577 C P+++V Sbjct: 606 VCGDGDPLIMV 616 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 93,793,891 Number of Sequences: 219361 Number of extensions: 1926392 Number of successful extensions: 6502 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6090 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6353 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5767334219 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
