ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags9j06 |
|---|---|
| Clone Library Name | barley_pub |
>CD2L1_HUMAN (P21127) PITSLRE serine/threonine-protein kinase CDC2L1 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1) Length = 795 Score = 222 bits (566), Expect = 2e-58 Identities = 100/139 (71%), Positives = 123/139 (88%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP 180 KQP+ EVK LM+QLL GVK+LHDNW++HRDLKTSN+LL++ G LK+ DFGL+R+YGSP Sbjct: 531 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 590 Query: 181 LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKI 360 LK YT +VVTLWYRAPELLLGAKEYSTA+DMWS+GCI ELL++KPLF GK +IDQ++K+ Sbjct: 591 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 650 Query: 361 FRMLGTPNEDIWPGYSKLP 417 F+ LGTP+E IWPGYS+LP Sbjct: 651 FKDLGTPSEKIWPGYSELP 669
>CD2L1_MOUSE (P24788) PITSLRE serine/threonine-protein kinase CDC2L1 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) Length = 784 Score = 222 bits (566), Expect = 2e-58 Identities = 101/139 (72%), Positives = 122/139 (87%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP 180 KQP+ EVK LM+QLL GVK+LHDNW++HRDLKTSN+LL++ G LK+ DFGL+R+YGSP Sbjct: 520 KQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 579 Query: 181 LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKI 360 LK YT +VVTLWYRAPELLLGAKEYSTA+DMWS+GCI ELL++KPLF GK DIDQ++KI Sbjct: 580 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSDIDQINKI 639 Query: 361 FRMLGTPNEDIWPGYSKLP 417 F+ LGTP+E IWPGY+ LP Sbjct: 640 FKDLGTPSEKIWPGYNDLP 658
>CD2L1_RAT (P46892) PITSLRE serine/threonine-protein kinase CDC2L1 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) Length = 436 Score = 221 bits (564), Expect = 4e-58 Identities = 101/139 (72%), Positives = 121/139 (87%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP 180 KQP+ EVK LM+QLL GVK+LHDNW++HRDLKTSN+LL + G LK+ DFGL+R+YGSP Sbjct: 172 KQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLTHAGILKVGDFGLAREYGSP 231 Query: 181 LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKI 360 LK YT +VVTLWYRAPELLLGAKEYSTA DMWS+GCI ELL++KPLF GK DIDQ++KI Sbjct: 232 LKAYTPVVVTLWYRAPELLLGAKEYSTACDMWSVGCIFGELLTQKPLFPGKSDIDQINKI 291 Query: 361 FRMLGTPNEDIWPGYSKLP 417 F+ +GTP+E IWPGYS+LP Sbjct: 292 FKDIGTPSEKIWPGYSELP 310
>CD2L2_HUMAN (Q9UQ88) PITSLRE serine/threonine-protein kinase CDC2L2 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11) Length = 780 Score = 218 bits (556), Expect = 4e-57 Identities = 98/139 (70%), Positives = 121/139 (87%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP 180 KQP+ EVK LM+QLL GVK+LHDNW++HRDLKTSN+LL++ G LK+ DFGL+R+YGSP Sbjct: 516 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 575 Query: 181 LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKI 360 LK YT +VVT WYRAPELLLGAKEYSTA+DMWS+GCI ELL++KPLF G +IDQ++K+ Sbjct: 576 LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKV 635 Query: 361 FRMLGTPNEDIWPGYSKLP 417 F+ LGTP+E IWPGYS+LP Sbjct: 636 FKELGTPSEKIWPGYSELP 654
>KP58_DROME (Q9VPC0) Serine/threonine-protein kinase PITSLRE (EC 2.7.11.22) (Cell| division cycle 2-like) Length = 952 Score = 197 bits (502), Expect = 6e-51 Identities = 91/139 (65%), Positives = 112/139 (80%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP 180 KQ + EVKCL QLL V +LHDNW++HRDLKTSN+LL++ G LK+ DFGL+R+YGSP Sbjct: 654 KQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSP 713 Query: 181 LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKI 360 +K YT LVVTLWYRAPELLL + YST ID+WS+GCI AE L PLF GK +ID+L++I Sbjct: 714 IKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKSEIDELNRI 773 Query: 361 FRMLGTPNEDIWPGYSKLP 417 F+ LGTPNE IWPGY++LP Sbjct: 774 FKELGTPNEKIWPGYTELP 792
>CDK10_HUMAN (Q15131) Cell division protein kinase 10 (EC 2.7.11.22)| (Serine/threonine-protein kinase PISSLRE) Length = 360 Score = 181 bits (459), Expect = 6e-46 Identities = 80/137 (58%), Positives = 111/137 (81%) Frame = +1 Query: 7 PYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLK 186 P+S+++VKC++LQ+L G++YLH N++IHRDLK SN+L+ + G +K DFGL+R YG P+K Sbjct: 134 PFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVK 193 Query: 187 PYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFR 366 P T VVTLWYRAPELLLG +T+IDMW++GCI+AELL+ +PL G +I Q+ I + Sbjct: 194 PMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQ 253 Query: 367 MLGTPNEDIWPGYSKLP 417 +LGTP+E+IWPG+SKLP Sbjct: 254 LLGTPSENIWPGFSKLP 270
>YP62_CAEEL (Q09437) Putative serine/threonine-protein kinase B0495.2 (EC| 2.7.11.1) Length = 719 Score = 178 bits (452), Expect = 4e-45 Identities = 78/135 (57%), Positives = 107/135 (79%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 +S E K L+ QLL G++++H W++HRDLKTSN+L+++ G LKI DFGL+R+YG PLK Sbjct: 456 FSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREYGDPLKK 515 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 +T +VVTLWYR+PELLLG + YST +DMWS+GCIMAE + KPLF G+ +++Q+ KIF Sbjct: 516 FTSIVVTLWYRSPELLLGTRLYSTPVDMWSVGCIMAEFILLKPLFPGRGELEQIKKIFME 575 Query: 370 LGTPNEDIWPGYSKL 414 +GTP E IWPG ++L Sbjct: 576 MGTPTESIWPGVTEL 590
>CDK3_HUMAN (Q00526) Cell division protein kinase 3 (EC 2.7.11.22)| Length = 305 Score = 175 bits (444), Expect = 3e-44 Identities = 77/131 (58%), Positives = 104/131 (79%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K + QLL+GV + H + VIHRDLK N+L+N G +K+ DFGL+R +G PL+ YT V Sbjct: 104 IKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEV 163 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG+K Y+TA+D+WS+GCI AE++++K LF G +IDQL +IFRMLGTP+ Sbjct: 164 VTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPS 223 Query: 385 EDIWPGYSKLP 417 ED WPG ++LP Sbjct: 224 EDTWPGVTQLP 234
>CDC28_YEAST (P00546) Cell division control protein 28 (EC 2.7.11.22)| Length = 298 Score = 172 bits (437), Expect = 2e-43 Identities = 77/138 (55%), Positives = 101/138 (73%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 QP VK M+QL +G+ Y H + ++HRDLK N+L+N G LK+ DFGL+R +G PL Sbjct: 106 QPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPL 165 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 + YT +VTLWYRAPE+LLG K+YST +D WS+GCI AE+ ++KP+F G +IDQ+ KIF Sbjct: 166 RAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIF 225 Query: 364 RMLGTPNEDIWPGYSKLP 417 R+LGTPNE IWP LP Sbjct: 226 RVLGTPNEAIWPDIVYLP 243
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 171 bits (434), Expect = 5e-43 Identities = 76/131 (58%), Positives = 102/131 (77%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + QLL+G+ + H + V+HRDLK N+L+N GE+K+ DFGL+R +G P++ YT V Sbjct: 104 VKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQGEIKLADFGLARAFGVPVRTYTHEV 163 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG K YSTA+D+WSLGCI AE++++K LF G +IDQL +IFR LGTP+ Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMITRKALFPGDSEIDQLFRIFRTLGTPD 223 Query: 385 EDIWPGYSKLP 417 E IWPG + +P Sbjct: 224 ESIWPGVTSMP 234
>CDC28_CANAL (P43063) Cell division control protein 28 (EC 2.7.11.22)| Length = 317 Score = 171 bits (434), Expect = 5e-43 Identities = 75/131 (57%), Positives = 102/131 (77%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K M QL+ G+K+ H + V+HRDLK N+L++ G LK+ DFGL+R +G PL+ YT V Sbjct: 110 IKRFMNQLIRGIKHCHSHRVLHRDLKPQNLLIDKEGNLKLADFGLARAFGVPLRAYTHEV 169 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG K+YST +DMWS+GCI AE+ ++KPLF G +ID++ +IFR+LGTPN Sbjct: 170 VTLWYRAPEILLGGKQYSTGVDMWSVGCIFAEMCNRKPLFPGDSEIDEIFRIFRILGTPN 229 Query: 385 EDIWPGYSKLP 417 E+IWP + LP Sbjct: 230 EEIWPDVNYLP 240
>CDC2H_PLAVI (Q9XZD6) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (Pvcrk2) Length = 288 Score = 170 bits (431), Expect = 1e-42 Identities = 75/130 (57%), Positives = 102/130 (78%) Frame = +1 Query: 28 KCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVV 207 K +LQLL G+ Y H++ V+HRDLK N+L+N GELKI DFGL+R +G P++ YT VV Sbjct: 103 KSFLLQLLSGIAYCHEHRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVV 162 Query: 208 TLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNE 387 TLWYRAP++L+G+K+YST IDMWS+GCI AE+++ +PLF G + DQL +IFR+LGTPN Sbjct: 163 TLWYRAPDILMGSKKYSTPIDMWSVGCIFAEMVNGRPLFPGVSETDQLMRIFRILGTPNS 222 Query: 388 DIWPGYSKLP 417 + WP ++LP Sbjct: 223 ENWPNVTELP 232
>CDC2_AJECA (P54119) Cell division control protein 2 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent protein kinase) Length = 324 Score = 169 bits (427), Expect = 3e-42 Identities = 73/134 (54%), Positives = 103/134 (76%) Frame = +1 Query: 16 QSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYT 195 ++ VK M QL+EG++Y H + V+HRDLK N+L++ G LK+ DFGL+R +G PL+ YT Sbjct: 122 EAMVKKFMAQLVEGIRYCHSHRVLHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRTYT 181 Query: 196 QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 VVTLWYRAPE+LLG ++YST +DMWS+G I AE+ ++KPLF G +ID++ KIF++LG Sbjct: 182 HEVVTLWYRAPEILLGGRQYSTGVDMWSVGAIFAEMCTRKPLFPGDSEIDEIFKIFKLLG 241 Query: 376 TPNEDIWPGYSKLP 417 TP+E+ WPG + P Sbjct: 242 TPDENTWPGVTSFP 255
>CDC2H_PLAFK (Q07785) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (PfPK5) Length = 288 Score = 167 bits (424), Expect = 7e-42 Identities = 75/130 (57%), Positives = 99/130 (76%) Frame = +1 Query: 28 KCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVV 207 K +LQLL G+ Y HD V+HRDLK N+L+N GELKI DFGL+R +G P++ YT VV Sbjct: 103 KSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVV 162 Query: 208 TLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNE 387 TLWYRAP++L+G+K+YST ID+WS+GCI AE+++ PLF G + DQL +IFR+LGTPN Sbjct: 163 TLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNS 222 Query: 388 DIWPGYSKLP 417 WP ++LP Sbjct: 223 KNWPNVTELP 232
>CDC2H_PLAF7 (P61075) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 167 bits (424), Expect = 7e-42 Identities = 75/130 (57%), Positives = 99/130 (76%) Frame = +1 Query: 28 KCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVV 207 K +LQLL G+ Y HD V+HRDLK N+L+N GELKI DFGL+R +G P++ YT VV Sbjct: 103 KSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVV 162 Query: 208 TLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNE 387 TLWYRAP++L+G+K+YST ID+WS+GCI AE+++ PLF G + DQL +IFR+LGTPN Sbjct: 163 TLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNS 222 Query: 388 DIWPGYSKLP 417 WP ++LP Sbjct: 223 KNWPNVTELP 232
>CDC2_EMENI (Q00646) Cell division control protein 2 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent protein kinase) Length = 323 Score = 167 bits (424), Expect = 7e-42 Identities = 73/131 (55%), Positives = 100/131 (76%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK M QL+EG+++ H + V+HRDLK N+L++ G LK+ DFGL+R +G PL+ YT V Sbjct: 124 VKKFMAQLIEGIRFCHSHRVLHRDLKPQNLLIDRDGNLKLADFGLARAFGVPLRTYTHEV 183 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYR+PE+LLG ++YST +DMWS G I AE+ ++KPLF G +ID++ KIFR+LGTP+ Sbjct: 184 VTLWYRSPEILLGGRQYSTGVDMWSCGAIFAEMCTRKPLFPGDSEIDEIFKIFRILGTPD 243 Query: 385 EDIWPGYSKLP 417 E IWPG + P Sbjct: 244 ETIWPGVTSFP 254
>CDC2H_PLAKH (O96821) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 167 bits (423), Expect = 9e-42 Identities = 74/130 (56%), Positives = 101/130 (77%) Frame = +1 Query: 28 KCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVV 207 K +LQLL G+ Y H++ V+HRDLK N+L+N GELKI DFGL+R +G P++ YT VV Sbjct: 103 KSFLLQLLSGIAYCHEHRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVV 162 Query: 208 TLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNE 387 TLWYRAP++L+G+K+YST ID+WS+GCI AE+++ +PLF G + DQL +IFR+LGTPN Sbjct: 163 TLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGVSETDQLMRIFRILGTPNS 222 Query: 388 DIWPGYSKLP 417 WP ++LP Sbjct: 223 ANWPSVTELP 232
>CDC2H_PLACH (Q4Y4B1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 167 bits (423), Expect = 9e-42 Identities = 75/130 (57%), Positives = 99/130 (76%) Frame = +1 Query: 28 KCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVV 207 K +LQLL G+ Y H++ V+HRDLK N+L+N GELKI DFGL+R +G P + YT VV Sbjct: 103 KSFLLQLLNGIAYCHEHRVLHRDLKPQNLLINREGELKIADFGLARAFGIPARRYTHEVV 162 Query: 208 TLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNE 387 TLWYRAP++L+G+K+YST ID+WS+GCI AE+++ +PLF G D DQL +IF++LGTPN Sbjct: 163 TLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGVSDTDQLMRIFKILGTPNS 222 Query: 388 DIWPGYSKLP 417 WP KLP Sbjct: 223 QNWPDVFKLP 232
>PEF1_SCHPO (O74456) Serine/threonine-protein kinase pef1 (EC 2.7.11.22)| (Cyclin-dependent kinase pef1) (PHO85 homolog) Length = 288 Score = 167 bits (422), Expect = 1e-41 Identities = 76/133 (57%), Positives = 102/133 (76%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQ 198 S+VK QLL+G+ + H+N V+HRDLK N+L+N+ GELK+ DFGL+R G P+ ++ Sbjct: 101 SQVKNFTQQLLKGISFCHENRVLHRDLKPQNLLINSRGELKLADFGLARSIGIPVNTFSN 160 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVTLWYRAP++LLG++ YST+ID+WS+GCIMAE+ + +PLF G + DQL KIFR+LGT Sbjct: 161 EVVTLWYRAPDVLLGSRVYSTSIDIWSVGCIMAEMATGRPLFAGSNNEDQLLKIFRLLGT 220 Query: 379 PNEDIWPGYSKLP 417 P E WPG S LP Sbjct: 221 PTEQSWPGISLLP 233
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 166 bits (421), Expect = 2e-41 Identities = 75/129 (58%), Positives = 99/129 (76%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK M QLL+G+ + HDN V+HRDLK N+L+NN GELK+ DFGL+R +G P ++ V Sbjct: 108 VKSFMFQLLKGIMFCHDNRVLHRDLKPQNLLINNKGELKLGDFGLARAFGIPFNTFSNEV 167 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAP++LLG++ Y+T+ID+WS GCI AE+ + KPLF G + DQL KIFR++GTPN Sbjct: 168 VTLWYRAPDVLLGSRAYTTSIDIWSAGCIFAEMCTGKPLFPGTANEDQLIKIFRLMGTPN 227 Query: 385 EDIWPGYSK 411 E WPG S+ Sbjct: 228 ERTWPGISQ 236
>CDK2_HUMAN (P24941) Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein| kinase) Length = 298 Score = 166 bits (420), Expect = 2e-41 Identities = 72/131 (54%), Positives = 101/131 (77%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K + QLL+G+ + H + V+HRDLK N+L+N G +K+ DFGL+R +G P++ YT V Sbjct: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV 163 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG K YSTA+D+WSLGCI AE+++++ LF G +IDQL +IFR LGTP+ Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 Query: 385 EDIWPGYSKLP 417 E +WPG + +P Sbjct: 224 EVVWPGVTSMP 234
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 166 bits (420), Expect = 2e-41 Identities = 72/131 (54%), Positives = 101/131 (77%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K + QLL+G+ + H + V+HRDLK N+L+N G +K+ DFGL+R +G P++ YT V Sbjct: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINADGSIKLADFGLARAFGVPVRTYTHEV 163 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG K YSTA+D+WSLGCI AE+++++ LF G +IDQL +IFR LGTP+ Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 Query: 385 EDIWPGYSKLP 417 E +WPG + +P Sbjct: 224 EVVWPGVTSMP 234
>CDC2H_PLABA (Q4Z6R1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 166 bits (420), Expect = 2e-41 Identities = 74/130 (56%), Positives = 99/130 (76%) Frame = +1 Query: 28 KCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVV 207 K +LQLL G+ Y H++ V+HRDLK N+L+N GELKI DFGL+R +G P + YT VV Sbjct: 103 KSFLLQLLNGIAYCHEHRVLHRDLKPQNLLINREGELKIADFGLARAFGIPARRYTHEVV 162 Query: 208 TLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNE 387 TLWYRAP++L+G+K+YST ID+WS+GCI AE+++ +PLF G + DQL +IF++LGTPN Sbjct: 163 TLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGASETDQLMRIFKILGTPNS 222 Query: 388 DIWPGYSKLP 417 WP KLP Sbjct: 223 QNWPDVFKLP 232
>CDK2_RAT (Q63699) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 166 bits (419), Expect = 3e-41 Identities = 72/131 (54%), Positives = 101/131 (77%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K + QLL+G+ + H + V+HRDLK N+L+N G +K+ DFGL+R +G P++ YT V Sbjct: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEV 163 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG K YSTA+D+WSLGCI AE+++++ LF G +IDQL +IFR LGTP+ Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 Query: 385 EDIWPGYSKLP 417 E +WPG + +P Sbjct: 224 EVVWPGVTSMP 234
>CDK2_MESAU (P48963) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 166 bits (419), Expect = 3e-41 Identities = 72/131 (54%), Positives = 101/131 (77%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K + QLL+G+ + H + V+HRDLK N+L+N G +K+ DFGL+R +G P++ YT V Sbjct: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEV 163 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG K YSTA+D+WSLGCI AE+++++ LF G +IDQL +IFR LGTP+ Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 Query: 385 EDIWPGYSKLP 417 E +WPG + +P Sbjct: 224 EVVWPGVTSMP 234
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 166 bits (419), Expect = 3e-41 Identities = 72/131 (54%), Positives = 101/131 (77%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K + QLL+G+ + H + V+HRDLK N+L+N G +K+ DFGL+R +G P++ YT V Sbjct: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEV 163 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG K YSTA+D+WSLGCI AE+++++ LF G +IDQL +IFR LGTP+ Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 Query: 385 EDIWPGYSKLP 417 E +WPG + +P Sbjct: 224 EVVWPGVTSMP 234
>CDC2B_ANTMA (Q38773) Cell division control protein 2 homolog B (EC 2.7.11.22)| (EC 2.7.11.23) (Fragment) Length = 280 Score = 166 bits (419), Expect = 3e-41 Identities = 73/132 (55%), Positives = 102/132 (77%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN-CGELKICDFGLSRQYGSPLKPYTQL 201 VK + Q+L GV Y H + V+HRDLK N+L++ +K+ DFGL+R +G P++ +T Sbjct: 91 VKMFLCQILRGVAYCHSHRVLHRDLKPQNLLIDRGSNTIKLADFGLARAFGIPVRTFTHE 150 Query: 202 VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTP 381 VVTLWYRAPE+LLG++ YST +D+WS+GCI AE++++KPLF G +ID+L KIFR++GTP Sbjct: 151 VVTLWYRAPEVLLGSRHYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELHKIFRIIGTP 210 Query: 382 NEDIWPGYSKLP 417 NEDIWPG + LP Sbjct: 211 NEDIWPGVTSLP 222
>CDC2H_PLAYO (Q7RM49) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 289 Score = 166 bits (419), Expect = 3e-41 Identities = 74/130 (56%), Positives = 99/130 (76%) Frame = +1 Query: 28 KCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVV 207 K +LQLL G+ Y H++ V+HRDLK N+L+N GELKI DFGL+R +G P + YT VV Sbjct: 104 KSFLLQLLNGIAYCHEHRVLHRDLKPQNLLINREGELKIADFGLARAFGIPARRYTHEVV 163 Query: 208 TLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNE 387 TLWYRAP++L+G+K+YST ID+WS+GCI AE+++ +PLF G + DQL +IF++LGTPN Sbjct: 164 TLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGVSETDQLMRIFKILGTPNS 223 Query: 388 DIWPGYSKLP 417 WP KLP Sbjct: 224 QNWPDVFKLP 233
>CDC2_DICDI (P34112) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 296 Score = 165 bits (418), Expect = 4e-41 Identities = 72/131 (54%), Positives = 100/131 (76%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K + QLL+G+ Y H + ++HRDLK N+L++ G LK+ DFGL+R P++ YT + Sbjct: 106 IKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYTHEI 165 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG+K YS +DMWS+GCI E+L+KKPLF G +IDQ+ +IFR+LGTP+ Sbjct: 166 VTLWYRAPEVLLGSKSYSVPVDMWSVGCIFGEMLNKKPLFSGDCEIDQIFRIFRVLGTPD 225 Query: 385 EDIWPGYSKLP 417 + IWPG +KLP Sbjct: 226 DSIWPGVTKLP 236
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 165 bits (418), Expect = 4e-41 Identities = 73/132 (55%), Positives = 99/132 (75%) Frame = +1 Query: 22 EVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQL 201 +VK M QLL G+ + HDN V+HRDLK N+L+N G+LK+ DFGL+R +G P+ ++ Sbjct: 106 QVKWFMYQLLRGILFCHDNRVLHRDLKPQNLLINAKGQLKLADFGLARAFGIPVNTFSNE 165 Query: 202 VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTP 381 VVTLWYRAP++LLG++ YST+ID+WS GCIMAE+ + +PLF G + DQL IF+++GTP Sbjct: 166 VVTLWYRAPDVLLGSRTYSTSIDIWSAGCIMAEMFTGRPLFPGSSNDDQLQHIFKLMGTP 225 Query: 382 NEDIWPGYSKLP 417 NE WP S LP Sbjct: 226 NESTWPNISSLP 237
>CDC21_ORYSA (P29618) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 294 Score = 165 bits (418), Expect = 4e-41 Identities = 74/132 (56%), Positives = 101/132 (76%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN-CGELKICDFGLSRQYGSPLKPYTQL 201 +K + Q+L GV Y H + V+HRDLK N+L++ LK+ DFGL+R +G P++ +T Sbjct: 104 IKSYLYQILRGVAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPVRTFTHE 163 Query: 202 VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTP 381 VVTLWYRAPE+LLG+++YST +DMWS+GCI AE++++KPLF G +ID+L KIFR+LGTP Sbjct: 164 VVTLWYRAPEILLGSRQYSTPVDMWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRVLGTP 223 Query: 382 NEDIWPGYSKLP 417 NE WPG S LP Sbjct: 224 NEQSWPGVSSLP 235
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 164 bits (415), Expect = 8e-41 Identities = 75/131 (57%), Positives = 96/131 (73%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + Q+LEG+ + H V+HRDLK N+L++N G +K+ DFGLSR +G P++ YT V Sbjct: 105 VKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLSRAFGVPVRVYTHEV 164 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG+ YST +D+WS G I AEL +KKPLF G +IDQL +IFR LGTPN Sbjct: 165 VTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN 224 Query: 385 EDIWPGYSKLP 417 D+WP LP Sbjct: 225 NDVWPDVESLP 235
>CDK7_MOUSE (Q03147) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinas Length = 346 Score = 164 bits (414), Expect = 1e-40 Identities = 71/133 (53%), Positives = 96/133 (72%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQ 198 S +K ML L+G++YLH +W++HRDLK +N+LL+ G LK+ DFGL++ +GSP + YT Sbjct: 112 SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH 171 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVT WYRAPELL GA+ Y +DMW++GCI+AELL + P G D+DQL++IF LGT Sbjct: 172 QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGT 231 Query: 379 PNEDIWPGYSKLP 417 P E+ WP LP Sbjct: 232 PTEEQWPDMCSLP 244
>CDK7_HUMAN (P50613) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) Length = 346 Score = 164 bits (414), Expect = 1e-40 Identities = 71/133 (53%), Positives = 96/133 (72%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQ 198 S +K ML L+G++YLH +W++HRDLK +N+LL+ G LK+ DFGL++ +GSP + YT Sbjct: 112 SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH 171 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVT WYRAPELL GA+ Y +DMW++GCI+AELL + P G D+DQL++IF LGT Sbjct: 172 QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGT 231 Query: 379 PNEDIWPGYSKLP 417 P E+ WP LP Sbjct: 232 PTEEQWPDMCSLP 244
>CDC2_MAIZE (P23111) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 164 bits (414), Expect = 1e-40 Identities = 74/132 (56%), Positives = 101/132 (76%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN-CGELKICDFGLSRQYGSPLKPYTQL 201 +K + Q+L GV Y H + V+HRDLK N+L++ LK+ DFGL+R +G P++ +T Sbjct: 104 IKSYLYQILHGVAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPVRTFTHE 163 Query: 202 VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTP 381 VVTLWYRAPE+LLGA++YST +D+WS+GCI AE++++KPLF G +ID+L KIFR+LGTP Sbjct: 164 VVTLWYRAPEILLGARQYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRILGTP 223 Query: 382 NEDIWPGYSKLP 417 NE WPG S LP Sbjct: 224 NEQSWPGVSCLP 235
>CDC2_CARAU (P51958) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 302 Score = 164 bits (414), Expect = 1e-40 Identities = 74/131 (56%), Positives = 97/131 (74%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + Q+LEG+ + H V+HRDLK N+L++N G +K+ DFGL+R +G P++ YT V Sbjct: 105 VKSYLYQILEGILFCHCRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEV 164 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLGA YST +D+WS+G I AEL +KKPLF G +IDQL +IFR LGTPN Sbjct: 165 VTLWYRAPEVLLGASRYSTPVDVWSIGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN 224 Query: 385 EDIWPGYSKLP 417 ++WP LP Sbjct: 225 NEVWPDVESLP 235
>CDC22_ORYSA (P29619) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 292 Score = 163 bits (413), Expect = 1e-40 Identities = 72/132 (54%), Positives = 100/132 (75%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN-CGELKICDFGLSRQYGSPLKPYTQL 201 VK + Q+L G+ Y H + V+HRDLK N+L++ LK+ DFGL+R +G P++ +T Sbjct: 103 VKSFLYQILRGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTHE 162 Query: 202 VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTP 381 VVTLWYRAPE+LLGA+ YST +DMWS+GCI AE++++KPLF G +ID+L KIF ++GTP Sbjct: 163 VVTLWYRAPEILLGARHYSTPVDMWSVGCIFAEMVNQKPLFPGDSEIDELFKIFSIMGTP 222 Query: 382 NEDIWPGYSKLP 417 NE+ WPG + LP Sbjct: 223 NEETWPGVASLP 234
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 163 bits (413), Expect = 1e-40 Identities = 72/131 (54%), Positives = 101/131 (77%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + QLL+G+ + H + V+HRDLK N+L+N+ G +K+ DFGL+R +G P++ +T V Sbjct: 104 VKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSDGAIKLADFGLARAFGVPVRTFTHEV 163 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG K YSTA+D+WSLGCI AE+++++ LF G +IDQL +IFR LGTP+ Sbjct: 164 VTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPD 223 Query: 385 EDIWPGYSKLP 417 E WPG + +P Sbjct: 224 EVSWPGVTTMP 234
>CDK7_XENLA (P20911) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (40 kDa protein kinase) (P40 MO15) (CDC2/CDK2,4-activating kinase) Length = 352 Score = 163 bits (412), Expect = 2e-40 Identities = 71/133 (53%), Positives = 97/133 (72%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQ 198 + +K ML L+G++YLH W++HRDLK +N+LL+ G LK+ DFGL++ +GSP + YT Sbjct: 118 AHIKSYMLMTLQGLEYLHHLWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRIYTH 177 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVT WYR+PELL GA+ Y +DMW++GCI+AELL + P G D+DQL++IF LGT Sbjct: 178 QVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGT 237 Query: 379 PNEDIWPGYSKLP 417 P E+ WPG S LP Sbjct: 238 PTEEQWPGMSSLP 250
>CDC2H_DICDI (P34117) CDC2-like serine/threonine-protein kinase CRP (EC| 2.7.11.22) (EC 2.7.11.23) Length = 292 Score = 163 bits (412), Expect = 2e-40 Identities = 73/135 (54%), Positives = 102/135 (75%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S+ +K M QLL+GV + HD+ V+HRDLK N+L+N GELK+ DFGL+R +G P++ Y Sbjct: 99 SKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPVRTY 158 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 + VVTLWYRAP++L+G+++YST ID+WS CI AE+ S +PLF G DQL +IF++L Sbjct: 159 SHEVVTLWYRAPDVLMGSRKYSTPIDIWSALCIFAEMASGRPLFPGSGTSDQLFRIFKIL 218 Query: 373 GTPNEDIWPGYSKLP 417 GTPNE+ WP ++LP Sbjct: 219 GTPNEESWPSITELP 233
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 163 bits (412), Expect = 2e-40 Identities = 74/131 (56%), Positives = 96/131 (73%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + Q+LEG+ + H V+HRDLK N+L++N G +K+ DFGL+R +G P++ YT V Sbjct: 105 VKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEV 164 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG+ YST +D+WS G I AEL +KKPLF G +IDQL +IFR LGTPN Sbjct: 165 VTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN 224 Query: 385 EDIWPGYSKLP 417 D+WP LP Sbjct: 225 NDVWPDVESLP 235
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 163 bits (412), Expect = 2e-40 Identities = 74/131 (56%), Positives = 96/131 (73%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + Q+LEG+ + H V+HRDLK N+L++N G +K+ DFGL+R +G P++ YT V Sbjct: 105 VKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEV 164 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG+ YST +D+WS G I AEL +KKPLF G +IDQL +IFR LGTPN Sbjct: 165 VTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN 224 Query: 385 EDIWPGYSKLP 417 D+WP LP Sbjct: 225 NDVWPDVESLP 235
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 163 bits (412), Expect = 2e-40 Identities = 74/131 (56%), Positives = 96/131 (73%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + Q+LEG+ + H V+HRDLK N+L++N G +K+ DFGL+R +G P++ YT V Sbjct: 105 VKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEV 164 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG+ YST +D+WS G I AEL +KKPLF G +IDQL +IFR LGTPN Sbjct: 165 VTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN 224 Query: 385 EDIWPGYSKLP 417 D+WP LP Sbjct: 225 NDVWPDVESLP 235
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 162 bits (411), Expect = 2e-40 Identities = 73/128 (57%), Positives = 97/128 (75%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + QLL+G+ + HDN V+HRDLK N+L+NN GELK+ DFGL+R +G P ++ V Sbjct: 108 VKSFIFQLLKGIMFCHDNRVLHRDLKPQNLLINNKGELKLGDFGLARAFGIPFNTFSNEV 167 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAP++LLG++ Y+ +ID+WS GCI AE+ + KPLF G + DQL KIFR++GTPN Sbjct: 168 VTLWYRAPDVLLGSRAYTASIDIWSAGCIFAEMCTGKPLFPGTSNDDQLIKIFRLMGTPN 227 Query: 385 EDIWPGYS 408 E WPG S Sbjct: 228 ERTWPGVS 235
>CDC2_VIGAC (Q41639) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 162 bits (409), Expect = 4e-40 Identities = 71/133 (53%), Positives = 102/133 (76%), Gaps = 1/133 (0%) Frame = +1 Query: 22 EVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN-CGELKICDFGLSRQYGSPLKPYTQ 198 +VK + Q+L G+ Y H + V+HRDLK N+L++ LK+ DFGL+R +G P++ +T Sbjct: 103 QVKMFLYQILCGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTH 162 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVTLWYRAPE+LLG++ YST +D+WS+GCI AE+++++PLF G +ID+L KIFR+LGT Sbjct: 163 EVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMVNRRPLFPGDSEIDELFKIFRILGT 222 Query: 379 PNEDIWPGYSKLP 417 PNE+ WPG + LP Sbjct: 223 PNEETWPGVTALP 235
>CDK7_RAT (P51952) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 protein kinase) (P39 Mo15) (Fragment) Length = 329 Score = 162 bits (409), Expect = 4e-40 Identities = 71/133 (53%), Positives = 95/133 (71%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQ 198 S +K ML L+G++YLH +W++HRDLK +N+LL+ G LK+ DFGL++ +GSP YT Sbjct: 104 SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNWAYTH 163 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVT WYRAPELL GA+ Y +DMW++GCI+AELL + P G D+DQL++IF LGT Sbjct: 164 QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGT 223 Query: 379 PNEDIWPGYSKLP 417 P E+ WP LP Sbjct: 224 PTEEQWPDMCSLP 236
>CDC2_CHERU (P93101) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 161 bits (408), Expect = 5e-40 Identities = 71/132 (53%), Positives = 100/132 (75%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN-CGELKICDFGLSRQYGSPLKPYTQL 201 +K + Q+L G+ Y H + V+HRDLK N+L++ LK+ DFGL+R +G P++ +T Sbjct: 104 IKRFLYQILRGIAYCHSHRVLHRDLKPQNLLIDRQTNALKLADFGLARAFGIPVRTFTHE 163 Query: 202 VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTP 381 VVTLWYRAPE+LLG++ YST +D+WS+GCI AE++++KPLF G +ID+L KIFR LGTP Sbjct: 164 VVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRTLGTP 223 Query: 382 NEDIWPGYSKLP 417 NE+ WPG + LP Sbjct: 224 NEETWPGVTSLP 235
>CDC2A_ANTMA (Q38772) Cell division control protein 2 homolog A (EC 2.7.11.22)| (EC 2.7.11.23) Length = 294 Score = 161 bits (408), Expect = 5e-40 Identities = 70/132 (53%), Positives = 101/132 (76%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN-CGELKICDFGLSRQYGSPLKPYTQL 201 VK + Q+L G+ Y H + V+HRDLK N+L++ LK+ DFGL+R +G P++ +T Sbjct: 104 VKMFLYQILRGIAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPVRTFTHE 163 Query: 202 VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTP 381 VVTLWYRAPE+LLG++ YST +D+WS+GCI AE+++++PLF G +ID+L KIFR++GTP Sbjct: 164 VVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMVNQRPLFPGDSEIDELFKIFRVMGTP 223 Query: 382 NEDIWPGYSKLP 417 NE+ WPG + LP Sbjct: 224 NEETWPGVTSLP 235
>CDK5_DROME (P48609) Cell division protein kinase 5 homolog (EC 2.7.11.22)| Length = 294 Score = 161 bits (407), Expect = 7e-40 Identities = 77/130 (59%), Positives = 98/130 (75%), Gaps = 1/130 (0%) Frame = +1 Query: 28 KCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVV 207 + MLQLL G+ + H + V+HRDLK N+L+N GELK+ DFGL+R +G P+K Y+ VV Sbjct: 104 RSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVV 163 Query: 208 TLWYRAPELLLGAKEYSTAIDMWSLGCIMAELL-SKKPLFDGKRDIDQLSKIFRMLGTPN 384 TLWYR P++L GAK Y+T+IDMWS GCI+AEL + +PLF G +DQL KIFR+LGTPN Sbjct: 164 TLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPN 223 Query: 385 EDIWPGYSKL 414 ED WPG S L Sbjct: 224 EDSWPGVSHL 233
>CDC2_VIGUN (P52389) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 161 bits (407), Expect = 7e-40 Identities = 70/133 (52%), Positives = 102/133 (76%), Gaps = 1/133 (0%) Frame = +1 Query: 22 EVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN-CGELKICDFGLSRQYGSPLKPYTQ 198 +VK + Q+L G+ Y H + V+HRDLK N+L++ LK+ DFGL+R +G P++ +T Sbjct: 103 QVKMFLYQILCGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTH 162 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVTLWYRAPE+LLG++ YST +D+WS+GC+ AE+++++PLF G +ID+L KIFR+LGT Sbjct: 163 EVVTLWYRAPEILLGSRHYSTPVDVWSVGCLFAEMVNRRPLFPGDSEIDELFKIFRILGT 222 Query: 379 PNEDIWPGYSKLP 417 PNE+ WPG + LP Sbjct: 223 PNEETWPGVTALP 235
>CDC2_SCHPO (P04551) Cell division control protein 2 (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinse) Length = 297 Score = 161 bits (407), Expect = 7e-40 Identities = 68/124 (54%), Positives = 96/124 (77%) Frame = +1 Query: 43 QLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVVTLWYR 222 QL+ GV + H +IHRDLK N+L++ G LK+ DFGL+R +G PL+ YT +VTLWYR Sbjct: 117 QLVNGVNFCHSRRIIHRDLKPQNLLIDKEGNLKLADFGLARSFGVPLRNYTHEIVTLWYR 176 Query: 223 APELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNEDIWPG 402 APE+LLG++ YST +D+WS+GCI AE++ + PLF G +ID++ KIF++LGTPNE++WPG Sbjct: 177 APEVLLGSRHYSTGVDIWSVGCIFAEMIRRSPLFPGDSEIDEIFKIFQVLGTPNEEVWPG 236 Query: 403 YSKL 414 + L Sbjct: 237 VTLL 240
>CDC22_MEDSA (Q05006) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 294 Score = 160 bits (405), Expect = 1e-39 Identities = 69/135 (51%), Positives = 102/135 (75%), Gaps = 1/135 (0%) Frame = +1 Query: 16 QSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGE-LKICDFGLSRQYGSPLKPY 192 Q ++K + Q+L G+ Y H + V+HRDLK N+L++ +K+ DFGL+R +G P++ + Sbjct: 101 QRQIKMFLYQILCGIAYCHSHRVLHRDLKPQNLLIDRSSNAVKLADFGLARAFGIPVRTF 160 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 T VVTLWYRAPE+LLG++ YST +D+WS+GCI AE+++++PLF G +ID+L KIFR+ Sbjct: 161 THEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMINQRPLFPGDSEIDELFKIFRIT 220 Query: 373 GTPNEDIWPGYSKLP 417 GTPNE+ WPG + LP Sbjct: 221 GTPNEETWPGVTSLP 235
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 160 bits (405), Expect = 1e-39 Identities = 69/131 (52%), Positives = 100/131 (76%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK QLL+G+ + H+N ++HRDLK N+L+N G+LK+ DFGL+R +G P+ ++ V Sbjct: 110 VKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV 169 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAP++L+G++ YST+ID+WS GCI+AE+++ KPLF G D +QL IF ++GTPN Sbjct: 170 VTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPN 229 Query: 385 EDIWPGYSKLP 417 E +WP +KLP Sbjct: 230 ESLWPSVTKLP 240
>CDC21_MEDSA (P24923) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (Fragment) Length = 291 Score = 160 bits (404), Expect = 1e-39 Identities = 71/133 (53%), Positives = 100/133 (75%), Gaps = 1/133 (0%) Frame = +1 Query: 22 EVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN-CGELKICDFGLSRQYGSPLKPYTQ 198 +VK + Q+L G+ Y H + V+HRDLK N+L++ LK+ DFGL+R +G P++ +T Sbjct: 100 QVKMFLYQMLCGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTH 159 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVTLWYRAPE+LLG++ YST +D+WS+GCI AE+ +++PL G +ID+L KIFR+LGT Sbjct: 160 EVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMANRRPLSPGDSEIDELFKIFRILGT 219 Query: 379 PNEDIWPGYSKLP 417 PNED WPG + LP Sbjct: 220 PNEDTWPGVTSLP 232
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 159 bits (402), Expect = 3e-39 Identities = 72/137 (52%), Positives = 99/137 (72%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q +S VK + Q+L+G+ + H V+HRDLK N+L+++ G +K+ DFGL+R +G P+ Sbjct: 98 QYLDRSRVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGVIKLADFGLARAFGIPV 157 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 + YT VVTLWYR+PE+LLG+ YST +D+WS+G I AEL +KKPLF G +IDQL +IF Sbjct: 158 RVYTHEVVTLWYRSPEVLLGSALYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF 217 Query: 364 RMLGTPNEDIWPGYSKL 414 R LGTPN D+WP L Sbjct: 218 RALGTPNNDVWPDVESL 234
>CDK7_CARAU (P51953) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (40 kDa protein kinase) (P40 MO15) (CDC2/CDK2,4-activating kinase) Length = 344 Score = 159 bits (402), Expect = 3e-39 Identities = 69/133 (51%), Positives = 97/133 (72%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQ 198 + +K +L L+G++Y+H++W++HRDLK +N+LL+ G LK+ DFGL++ +GSP + YT Sbjct: 111 ANIKAYILMSLQGLEYMHNHWILHRDLKPNNLLLDENGVLKLADFGLAKAFGSPNRVYTH 170 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVT WYRAPELL GA+ Y +DMW++G I+AELL + P G D+DQL+ IF LGT Sbjct: 171 QVVTRWYRAPELLFGARMYGVGVDMWAVGSILAELLLRVPFLAGDSDLDQLTGIFEALGT 230 Query: 379 PNEDIWPGYSKLP 417 P E+ WPG S LP Sbjct: 231 PTEETWPGMSNLP 243
>CDC2A_ARATH (P24100) Cell division control protein 2 homolog A (EC 2.7.11.22)| (EC 2.7.11.23) Length = 294 Score = 159 bits (401), Expect = 3e-39 Identities = 71/132 (53%), Positives = 98/132 (74%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN-CGELKICDFGLSRQYGSPLKPYTQL 201 +K + Q+L G+ Y H + V+HRDLK N+L++ LK+ DFGL+R +G P++ +T Sbjct: 104 IKTYLYQILRGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTHE 163 Query: 202 VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTP 381 VVTLWYRAPE+LLG+ YST +D+WS+GCI AE++S+KPLF G +IDQL KIFR++GTP Sbjct: 164 VVTLWYRAPEILLGSHHYSTPVDIWSVGCIFAEMISQKPLFPGDSEIDQLFKIFRIMGTP 223 Query: 382 NEDIWPGYSKLP 417 ED W G + LP Sbjct: 224 YEDTWRGVTSLP 235
>CDC2H_THEAN (Q26671) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 159 bits (401), Expect = 3e-39 Identities = 69/130 (53%), Positives = 97/130 (74%) Frame = +1 Query: 28 KCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVV 207 K + Q+L G+ Y HD+ ++HRDLK N+L+N G LK+ DFGL+R + P++ YT VV Sbjct: 103 KSFLYQILRGISYCHDHRILHRDLKPQNLLINREGVLKLADFGLARAFAIPVRSYTHEVV 162 Query: 208 TLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNE 387 TLWYRAP++L+G+K+YSTA+D+WS+GCI AE+++ PLF G + DQL +IF++LGTPN Sbjct: 163 TLWYRAPDVLMGSKKYSTAVDIWSVGCIFAEMINGVPLFPGISEQDQLKRIFKILGTPNV 222 Query: 388 DIWPGYSKLP 417 D WP LP Sbjct: 223 DSWPQVVNLP 232
>CDC22_XENLA (P24033) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 2) Length = 302 Score = 158 bits (399), Expect = 6e-39 Identities = 70/130 (53%), Positives = 96/130 (73%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + Q+L+G+ + H V+HRDLK N+L++N G +K+ DFGL+R +G P++ YT V Sbjct: 105 VKSYLYQILQGIVFCHSRGVLHRDLKPQNLLIDNKGVIKLADFGLARAFGIPVRVYTHEV 164 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG+ YST +D+WS+G I AE+ +KKPLF G +IDQL +IFR LGTPN Sbjct: 165 VTLWYRAPEVLLGSVRYSTPVDVWSVGTIFAEIATKKPLFHGDSEIDQLFRIFRSLGTPN 224 Query: 385 EDIWPGYSKL 414 ++WP L Sbjct: 225 NEVWPEVESL 234
>CDC2C_DROME (P23573) Cell division control protein 2 cognate (EC 2.7.11.22) (EC| 2.7.11.23) Length = 314 Score = 158 bits (399), Expect = 6e-39 Identities = 69/139 (49%), Positives = 100/139 (71%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP 180 K ++ +K M Q+L+ V + H N ++HRDLK N+L++ G++K+ DFGL+R + P Sbjct: 99 KDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLLVDTAGKIKLADFGLARAFNVP 158 Query: 181 LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKI 360 ++ YT VVTLWYRAPE+LLG K YST +D+WSLGCI +E++ ++ LF G +IDQL +I Sbjct: 159 MRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEMIMRRSLFPGDSEIDQLYRI 218 Query: 361 FRMLGTPNEDIWPGYSKLP 417 FR L TP+E WPG ++LP Sbjct: 219 FRTLSTPDETNWPGVTQLP 237
>CDC2_PONPY (Q5RCH1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 157 bits (398), Expect = 7e-39 Identities = 71/137 (51%), Positives = 98/137 (71%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S VK + Q+L+G+ + H V+HRDLK N+L+++ G +K+ DFGL+R +G P+ Sbjct: 98 QYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI 157 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 + YT VVTLWYR+PE+LLG+ YST +D+WS+G I AEL +KKPLF G +IDQL +IF Sbjct: 158 RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF 217 Query: 364 RMLGTPNEDIWPGYSKL 414 R LGTPN ++WP L Sbjct: 218 RALGTPNNEVWPEVESL 234
>CDC2_HUMAN (P06493) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 157 bits (398), Expect = 7e-39 Identities = 71/137 (51%), Positives = 98/137 (71%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S VK + Q+L+G+ + H V+HRDLK N+L+++ G +K+ DFGL+R +G P+ Sbjct: 98 QYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI 157 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 + YT VVTLWYR+PE+LLG+ YST +D+WS+G I AEL +KKPLF G +IDQL +IF Sbjct: 158 RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF 217 Query: 364 RMLGTPNEDIWPGYSKL 414 R LGTPN ++WP L Sbjct: 218 RALGTPNNEVWPEVESL 234
>BUR1_NEUCR (Q871M9) Serine/threonine-protein kinase bur-1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 545 Score = 157 bits (397), Expect = 1e-38 Identities = 72/147 (48%), Positives = 101/147 (68%), Gaps = 11/147 (7%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY------ 171 +++ +VKC +LQLLEG+KYLH N ++HRD+K +N+L+NN G L+I DFGL+R Y Sbjct: 129 FTEPQVKCYLLQLLEGLKYLHANHILHRDMKAANLLINNKGVLQIADFGLARHYEGDIPQ 188 Query: 172 -----GSPLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKR 336 G + YT LVVT WYR PELL+ K Y+TAIDMW +GC+ AE+L KP+ G+ Sbjct: 189 PGKGSGEGKRDYTSLVVTRWYRPPELLMHLKRYTTAIDMWGVGCVFAEMLEGKPVLQGES 248 Query: 337 DIDQLSKIFRMLGTPNEDIWPGYSKLP 417 D+ QL ++ + GTP+E+ PG+ LP Sbjct: 249 DLHQLELVWDLCGTPSEETMPGWRTLP 275
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 157 bits (397), Expect = 1e-38 Identities = 70/132 (53%), Positives = 97/132 (73%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQ 198 S VK + Q+L+G+ + H V+HRDLK N+L+++ G +K+ DFGL+R +G P++ YT Sbjct: 103 SLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTH 162 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVTLWYR+PE+LLG+ YST +D+WS+G I AEL +KKPLF G +IDQL +IFR LGT Sbjct: 163 EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT 222 Query: 379 PNEDIWPGYSKL 414 PN ++WP L Sbjct: 223 PNNEVWPEVESL 234
>CDK7_DICDI (P54685) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (MO15 homolog) Length = 362 Score = 157 bits (397), Expect = 1e-38 Identities = 71/133 (53%), Positives = 97/133 (72%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQ 198 +++K M LL+G++ H NWV+HRDLK +N+L++ G+LK+ DFGL+RQYGSP K ++ Sbjct: 105 ADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSINGDLKLADFGLARQYGSPNKVFSP 164 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VT++YRAPELL GAK Y ++D+WS+GCI AEL+ + P G +IDQL KI LGT Sbjct: 165 QAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYLPGTGEIDQLRKICSALGT 224 Query: 379 PNEDIWPGYSKLP 417 PNE WPG + LP Sbjct: 225 PNESNWPGVTCLP 237
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 157 bits (397), Expect = 1e-38 Identities = 69/131 (52%), Positives = 97/131 (74%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK QLLEG+ + H+N ++HRDLK N+L+ G+LK+ DFGL+R +G P+ ++ V Sbjct: 109 VKYFQWQLLEGLAFCHENKILHRDLKPQNLLITKRGQLKLGDFGLARAFGIPVNTFSSEV 168 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAP++L+G++ YST+ID+WS GCI+AE+++ KPLF G D +QL IF +GTPN Sbjct: 169 VTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDKMGTPN 228 Query: 385 EDIWPGYSKLP 417 E WPG + LP Sbjct: 229 ETTWPGVTSLP 239
>CDK5_RAT (Q03114) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 157 bits (396), Expect = 1e-38 Identities = 75/132 (56%), Positives = 97/132 (73%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK L+ QLL+G+ + H V+HRDLK N+L+N GELK+ DFGL+R +G P++ Y+ V Sbjct: 103 VKSLLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSK-KPLFDGKRDIDQLSKIFRMLGTP 381 VTLWYR P++L GAK YST+IDMWS GCI AEL + +PLF G DQL +IFR+LGTP Sbjct: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 Query: 382 NEDIWPGYSKLP 417 E+ WP +KLP Sbjct: 223 TEEQWPAMTKLP 234
>CDC2H_THEPA (Q27032) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 157 bits (396), Expect = 1e-38 Identities = 68/130 (52%), Positives = 97/130 (74%) Frame = +1 Query: 28 KCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVV 207 K + Q+L G+ Y HD+ ++HRDLK N+L+N G LK+ DFGL+R + P++ YT VV Sbjct: 103 KSFLYQILRGISYCHDHRILHRDLKPQNLLINREGVLKLADFGLARAFAIPVRSYTHEVV 162 Query: 208 TLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNE 387 TLWYRAP++L+G+K+YSTA+D+WS+GCI AE+++ PLF G + DQL +IF++LGTP+ Sbjct: 163 TLWYRAPDVLMGSKKYSTAVDIWSVGCIFAEMINGVPLFPGISEQDQLKRIFKILGTPSV 222 Query: 388 DIWPGYSKLP 417 D WP LP Sbjct: 223 DSWPQVVNLP 232
>CDK5_XENLA (P51166) Cell division protein kinase 5 (EC 2.7.11.22) (Neuronal| cyclin-dependent kinase 5) Length = 292 Score = 156 bits (395), Expect = 2e-38 Identities = 75/132 (56%), Positives = 96/132 (72%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK M QLL+G+ + H V+HRDLK N+L+N GELK+ DFGL+R +G P++ Y+ V Sbjct: 103 VKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSK-KPLFDGKRDIDQLSKIFRMLGTP 381 VTLWYR P++L GAK YST+IDMWS GCI AEL + +PLF G DQL +IFR+LGTP Sbjct: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 Query: 382 NEDIWPGYSKLP 417 E+ WP +KLP Sbjct: 223 TEEQWPAMTKLP 234
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 156 bits (395), Expect = 2e-38 Identities = 70/132 (53%), Positives = 97/132 (73%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQ 198 S VK + Q+L+G+ + H V+HRDLK N+L+++ G +K+ DFGL+R +G P++ YT Sbjct: 103 SLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTH 162 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVTLWYR+PE+LLG+ YST +D+WS+G I AEL +KKPLF G +IDQL +IFR LGT Sbjct: 163 EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT 222 Query: 379 PNEDIWPGYSKL 414 PN ++WP L Sbjct: 223 PNNEVWPEVESL 234
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 156 bits (395), Expect = 2e-38 Identities = 70/132 (53%), Positives = 97/132 (73%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQ 198 S VK + Q+L+G+ + H V+HRDLK N+L+++ G +K+ DFGL+R +G P++ YT Sbjct: 103 SLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTH 162 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVTLWYR+PE+LLG+ YST +D+WS+G I AEL +KKPLF G +IDQL +IFR LGT Sbjct: 163 EVVTLWYRSPEVLLGSAGYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT 222 Query: 379 PNEDIWPGYSKL 414 PN ++WP L Sbjct: 223 PNNEVWPEVESL 234
>CDK5_BOVIN (Q02399) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Proline-directed protein kinase 33 kDa subunit) (PDPK) Length = 292 Score = 156 bits (394), Expect = 2e-38 Identities = 74/132 (56%), Positives = 97/132 (73%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + QLL+G+ + H V+HRDLK N+L+N GELK+ DFGL+R +G P++ Y+ V Sbjct: 103 VKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSK-KPLFDGKRDIDQLSKIFRMLGTP 381 VTLWYR+P++L GAK YST+IDMWS GCI AEL + +PLF G DQL +IFR+LGTP Sbjct: 163 VTLWYRSPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 Query: 382 NEDIWPGYSKLP 417 E+ WP +KLP Sbjct: 223 TEEQWPAMTKLP 234
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 156 bits (394), Expect = 2e-38 Identities = 69/130 (53%), Positives = 96/130 (73%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + Q+L+G+ + H V+HRDLK N+L+++ G +K+ DFGL+R +G P++ YT V Sbjct: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDSKGVIKLADFGLARAFGIPVRVYTHEV 164 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG+ YST +D+WS+G I AE+ +KKPLF G +IDQL +IFR LGTPN Sbjct: 165 VTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIATKKPLFHGDSEIDQLFRIFRALGTPN 224 Query: 385 EDIWPGYSKL 414 ++WP L Sbjct: 225 NEVWPEVESL 234
>BUR1_ASPFU (Q4WTN5) Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 580 Score = 155 bits (393), Expect = 3e-38 Identities = 71/147 (48%), Positives = 99/147 (67%), Gaps = 11/147 (7%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP--- 180 +++ ++KC MLQLLEG+KYLH N ++HRD+K +N+L++N G L+I DFGL+R Y P Sbjct: 127 FTEPQIKCYMLQLLEGLKYLHGNRILHRDMKAANLLISNNGVLQIADFGLARPYDEPPPE 186 Query: 181 --------LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKR 336 + YT LVVT WYR PELLL + Y+TAIDMW +GC+ E+ KP+ G Sbjct: 187 PGKGGGEAKRDYTTLVVTRWYRPPELLLQLRRYTTAIDMWGVGCVFGEMFKGKPILAGSS 246 Query: 337 DIDQLSKIFRMLGTPNEDIWPGYSKLP 417 D++Q IF ++GTP E+ PG+S LP Sbjct: 247 DLNQTQLIFNLVGTPTEENMPGWSSLP 273
>CDK5_MOUSE (P49615) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6) Length = 292 Score = 155 bits (392), Expect = 4e-38 Identities = 74/132 (56%), Positives = 96/132 (72%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + QLL+G+ + H V+HRDLK N+L+N GELK+ DFGL+R +G P++ Y+ V Sbjct: 103 VKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSK-KPLFDGKRDIDQLSKIFRMLGTP 381 VTLWYR P++L GAK YST+IDMWS GCI AEL + +PLF G DQL +IFR+LGTP Sbjct: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 Query: 382 NEDIWPGYSKLP 417 E+ WP +KLP Sbjct: 223 TEEQWPAMTKLP 234
>CDK5_HUMAN (Q00535) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 155 bits (392), Expect = 4e-38 Identities = 74/132 (56%), Positives = 96/132 (72%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + QLL+G+ + H V+HRDLK N+L+N GELK+ DFGL+R +G P++ Y+ V Sbjct: 103 VKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSK-KPLFDGKRDIDQLSKIFRMLGTP 381 VTLWYR P++L GAK YST+IDMWS GCI AEL + +PLF G DQL +IFR+LGTP Sbjct: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222 Query: 382 NEDIWPGYSKLP 417 E+ WP +KLP Sbjct: 223 TEEQWPSMTKLP 234
>BUR1_YARLI (Q6C842) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 706 Score = 155 bits (392), Expect = 4e-38 Identities = 73/145 (50%), Positives = 98/145 (67%), Gaps = 10/145 (6%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL--- 183 S + +KC MLQLLEG+ YLH +HRD+K +NIL+N+ G LK+ DFGL+R Y P Sbjct: 141 SPAHIKCYMLQLLEGIGYLHAKKFLHRDIKAANILVNDQGILKLADFGLARGYDGPAPNS 200 Query: 184 -------KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDI 342 + T +VVT WYR PEL+LG ++Y+TAIDMW +GC+ E ++KP+F G D+ Sbjct: 201 QTAGVNTENLTAMVVTRWYRPPELILGDRKYTTAIDMWGIGCVFGEFFTRKPIFPGASDV 260 Query: 343 DQLSKIFRMLGTPNEDIWPGYSKLP 417 DQ SKIF+ +G P ED PG+S LP Sbjct: 261 DQGSKIFQAVGVPTEDTMPGWSVLP 285
>CDC2_CAEEL (P34556) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 332 Score = 155 bits (391), Expect = 5e-38 Identities = 70/131 (53%), Positives = 94/131 (71%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K Q+L+ + + H VIHRDLK N+L++N G +K+ DFGL+R G P++ YT V Sbjct: 123 LKSYTFQILQAMCFCHQRRVIHRDLKPQNLLVDNNGAIKLADFGLARAIGIPIRVYTHEV 182 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+L+GA+ YS +DMWS+GCI AE+ +KKPLF G +ID+L +IFR+LGTP Sbjct: 183 VTLWYRAPEILMGAQRYSMGVDMWSIGCIFAEMATKKPLFQGDSEIDELFRIFRVLGTPT 242 Query: 385 EDIWPGYSKLP 417 E W G LP Sbjct: 243 ELEWNGVESLP 253
>CCRK_HUMAN (Q8IZL9) Cell cycle-related kinase (EC 2.7.11.22)| (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) Length = 346 Score = 155 bits (391), Expect = 5e-38 Identities = 73/142 (51%), Positives = 102/142 (71%), Gaps = 3/142 (2%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY--- 171 ++P +Q++VK + LL+GV + H N ++HRDLK +N+L++ G+LKI DFGL+R + Sbjct: 96 QRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPD 155 Query: 172 GSPLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 GS L YT V T WYRAPELL GA++Y +D+WS+GCIM ELL+ PLF GK DI+QL Sbjct: 156 GSRL--YTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQL 213 Query: 352 SKIFRMLGTPNEDIWPGYSKLP 417 + R+LGTPN +WP ++LP Sbjct: 214 CYVLRILGTPNPQVWPELTELP 235
>CCRK_PONPY (Q5R7I7) Cell cycle-related kinase (EC 2.7.11.22)| Length = 346 Score = 154 bits (389), Expect = 8e-38 Identities = 72/142 (50%), Positives = 102/142 (71%), Gaps = 3/142 (2%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY--- 171 ++P +Q++VK + LL+GV + H N ++HRDLK +N+L++ G+LKI DFGL+R + Sbjct: 96 QRPLAQAQVKSYLQMLLKGVSFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPD 155 Query: 172 GSPLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 GS L YT V T WYRAPELL GA++Y +D+W++GCIM ELL+ PLF GK DI+QL Sbjct: 156 GSRL--YTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGKNDIEQL 213 Query: 352 SKIFRMLGTPNEDIWPGYSKLP 417 + R+LGTPN +WP ++LP Sbjct: 214 CYVLRILGTPNPQVWPELTELP 235
>CDC2_DROME (P23572) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 297 Score = 154 bits (389), Expect = 8e-38 Identities = 66/131 (50%), Positives = 94/131 (71%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 V+ + Q+ + + H V+HRDLK N+L++ G +K+ DFGL R +G P++ YT + Sbjct: 105 VRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEI 164 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG+ YS +D+WS+GCI AE+ ++KPLF G +IDQL ++FR+L TP Sbjct: 165 VTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPT 224 Query: 385 EDIWPGYSKLP 417 EDIWPG + LP Sbjct: 225 EDIWPGVTSLP 235
>CDK9_SCHPO (Q96WV9) Serine/threonine-protein kinase cdk9 (EC 2.7.11.1)| (Cyclin-dependent kinase cdk9) Length = 591 Score = 154 bits (388), Expect = 1e-37 Identities = 74/149 (49%), Positives = 99/149 (66%), Gaps = 13/149 (8%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY------ 171 +++ ++KC M QL G KYLHD ++HRDLK +N+L++N G LKI DFGL+R Sbjct: 138 FTEPQIKCYMKQLFAGTKYLHDQLILHRDLKAANLLIDNHGILKIADFGLARVITEESYA 197 Query: 172 ----GSP---LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDG 330 G P + YT VVT WYR+PELLLG + Y+TAIDMWS+GCIMAE+ +P+ G Sbjct: 198 NKNPGLPPPNRREYTGCVVTRWYRSPELLLGERRYTTAIDMWSVGCIMAEMYKGRPILQG 257 Query: 331 KRDIDQLSKIFRMLGTPNEDIWPGYSKLP 417 D+DQL KIFR+ G+P + P + KLP Sbjct: 258 SSDLDQLDKIFRLCGSPTQATMPNWEKLP 286
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 153 bits (387), Expect = 1e-37 Identities = 69/133 (51%), Positives = 96/133 (72%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQ 198 S VK QLL+GV + H+N ++HRDLK N+L+NN G+LK+ DFGL+R +G P+ ++ Sbjct: 110 SLVKYFQWQLLQGVAFCHENRILHRDLKPQNLLINNKGQLKLGDFGLARAFGIPVNTFSS 169 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVTLWYRAP++L+G++ Y T+ID+WS GCI+AE++ K LF G D +QL IF +GT Sbjct: 170 EVVTLWYRAPDVLMGSRTYCTSIDIWSCGCILAEMIMGKALFPGTNDDEQLKLIFETMGT 229 Query: 379 PNEDIWPGYSKLP 417 P E W G S+LP Sbjct: 230 PTEQTWVGVSQLP 242
>PFTK1_MOUSE (O35495) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 153 bits (387), Expect = 1e-37 Identities = 69/132 (52%), Positives = 92/132 (69%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + QLL G+ Y+H +++HRDLK N+L+++ GELK+ DFGL+R P Y+ V Sbjct: 233 VKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEV 292 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDI-DQLSKIFRMLGTP 381 VTLWYR P++LLG+ EYST +DMW +GCI E++ F G +DI DQL +IF +LGTP Sbjct: 293 VTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTP 352 Query: 382 NEDIWPGYSKLP 417 NED WPG LP Sbjct: 353 NEDTWPGVHSLP 364
>PFTK1_HUMAN (O94921) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 153 bits (387), Expect = 1e-37 Identities = 69/132 (52%), Positives = 92/132 (69%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + QLL G+ Y+H +++HRDLK N+L+++ GELK+ DFGL+R P Y+ V Sbjct: 233 VKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEV 292 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDI-DQLSKIFRMLGTP 381 VTLWYR P++LLG+ EYST +DMW +GCI E++ F G +DI DQL +IF +LGTP Sbjct: 293 VTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTP 352 Query: 382 NEDIWPGYSKLP 417 NED WPG LP Sbjct: 353 NEDTWPGVHSLP 364
>CDC2D_ANTMA (Q38775) Cell division control protein 2 homolog D (EC 2.7.11.22)| (EC 2.7.11.23) Length = 312 Score = 153 bits (386), Expect = 2e-37 Identities = 74/131 (56%), Positives = 95/131 (72%), Gaps = 1/131 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN-CGELKICDFGLSRQYGSPLKPYTQL 201 VK LM QL +GV + H + V+HRDLK N+L++ LKI D GL+R Y P+K YT Sbjct: 122 VKSLMYQLCKGVAFCHGHGVLHRDLKPHNLLMDRKTMMLKIADLGLARAYTLPIKKYTHE 181 Query: 202 VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTP 381 ++TLWYRAPE+LLGA YS A+DMWS+ CI AEL+++K LF G ++ QL IFR+LGTP Sbjct: 182 ILTLWYRAPEVLLGATHYSPAVDMWSVACIFAELVTQKALFPGDSELQQLLHIFRLLGTP 241 Query: 382 NEDIWPGYSKL 414 NE+IWPG S L Sbjct: 242 NEEIWPGVSTL 252
>BUR1_EMENI (Q96VK3) Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC| 2.7.11.23) (Pitalre-like kinase A) Length = 544 Score = 153 bits (386), Expect = 2e-37 Identities = 69/147 (46%), Positives = 100/147 (68%), Gaps = 11/147 (7%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY------ 171 +S++++KC M+QLLEG+KYLH N ++HRD+K +N+L++N G L+I DFGL+R + Sbjct: 127 FSEAQIKCYMIQLLEGLKYLHGNCILHRDMKAANLLISNQGILQIADFGLARPFDEAPPQ 186 Query: 172 -----GSPLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKR 336 G + YT LVVT WYR PELLL + Y++AIDMW +GC+ E+ KP+ G Sbjct: 187 PGKGAGEAKRDYTTLVVTRWYRPPELLLQLRRYTSAIDMWGVGCVFGEMFKGKPILAGNS 246 Query: 337 DIDQLSKIFRMLGTPNEDIWPGYSKLP 417 D++Q IF ++GTP E+ PG+S LP Sbjct: 247 DLNQAQLIFSLVGTPTEENMPGWSSLP 273
>CD2L7_HUMAN (Q9NYV4) Cell division cycle 2-related protein kinase 7 (EC| 2.7.11.22) (CDC2-related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) Length = 1490 Score = 152 bits (385), Expect = 2e-37 Identities = 70/137 (51%), Positives = 95/137 (69%), Gaps = 1/137 (0%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP-LK 186 +S+ +K M QL+EG++Y H +HRD+K SNILLNN G++K+ DFGL+R Y S + Sbjct: 831 FSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESR 890 Query: 187 PYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFR 366 PYT V+TLWYR PELLLG + Y+ AID+WS GCI+ EL +KKP+F ++ QL I R Sbjct: 891 PYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISR 950 Query: 367 MLGTPNEDIWPGYSKLP 417 + G+P +WP KLP Sbjct: 951 LCGSPCPAVWPDVIKLP 967
>CC2H1_TRYBB (P38973) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 151 bits (382), Expect = 5e-37 Identities = 67/127 (52%), Positives = 90/127 (70%) Frame = +1 Query: 37 MLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVVTLW 216 M LL GV++ H+ V+HRDLK N+L++ ELK+ DFGL R +G P+K +TQ VVTLW Sbjct: 108 MRSLLSGVRFCHERNVLHRDLKPPNLLISREKELKLADFGLGRAFGIPVKKFTQEVVTLW 167 Query: 217 YRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNEDIW 396 YR+P++LLG+ +Y T +D+WS+GCI AE+ PLF GK D DQL +IF+ LGTPN +W Sbjct: 168 YRSPDVLLGSTQYGTPVDIWSVGCIFAEMAIGAPLFTGKNDADQLLRIFQFLGTPNRQVW 227 Query: 397 PGYSKLP 417 P P Sbjct: 228 PSMDTYP 234
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 151 bits (382), Expect = 5e-37 Identities = 67/130 (51%), Positives = 95/130 (73%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK QLL+GV + H+N ++HRDLK N+L+NN G+LK+ DFGL+R +G P+ ++ V Sbjct: 110 VKYFQWQLLQGVAFCHENRILHRDLKPQNLLINNRGQLKLGDFGLARAFGIPVNTFSSEV 169 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAP++L+G++ Y T+ID+WS GCI+AE++ KPLF G D +QL IF +GTP Sbjct: 170 VTLWYRAPDVLMGSRNYCTSIDIWSCGCILAEMIMGKPLFPGSNDEEQLKLIFDTMGTPV 229 Query: 385 EDIWPGYSKL 414 E WP ++L Sbjct: 230 EQTWPQVTQL 239
>CD2L5_MOUSE (Q69ZA1) Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22)| (CDC2-related protein kinase 5) Length = 1511 Score = 151 bits (381), Expect = 7e-37 Identities = 69/137 (50%), Positives = 96/137 (70%), Gaps = 1/137 (0%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP-LK 186 ++++ +K M QL+EG+ Y H +HRD+K SNILLNN G++K+ DFGL+R Y S + Sbjct: 809 FNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESR 868 Query: 187 PYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFR 366 PYT V+TLWYR PELLLG + Y+ AID+WS GCI+ EL +KKP+F +++ QL I R Sbjct: 869 PYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISR 928 Query: 367 MLGTPNEDIWPGYSKLP 417 + G+P +WP KLP Sbjct: 929 ICGSPCPAVWPDVIKLP 945
>CD2L5_HUMAN (Q14004) Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22)| (CDC2-related protein kinase 5) (Cholinesterase-related cell division controller) Length = 1512 Score = 151 bits (381), Expect = 7e-37 Identities = 69/137 (50%), Positives = 96/137 (70%), Gaps = 1/137 (0%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP-LK 186 ++++ +K M QL+EG+ Y H +HRD+K SNILLNN G++K+ DFGL+R Y S + Sbjct: 809 FNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESR 868 Query: 187 PYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFR 366 PYT V+TLWYR PELLLG + Y+ AID+WS GCI+ EL +KKP+F +++ QL I R Sbjct: 869 PYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISR 928 Query: 367 MLGTPNEDIWPGYSKLP 417 + G+P +WP KLP Sbjct: 929 ICGSPCPAVWPDVIKLP 945
>PCTK3_MOUSE (Q04899) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 150 bits (380), Expect = 9e-37 Identities = 69/130 (53%), Positives = 90/130 (69%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK M QLL G+ Y H ++HRDLK N+L+N GELK+ DFGL+R P K Y+ V Sbjct: 219 VKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEV 278 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYR P++LLG+ EYST IDMW +GCI+ E+ + KPLF G ++L IFR+LGTP Sbjct: 279 VTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPLFPGSTVKEELHLIFRLLGTPT 338 Query: 385 EDIWPGYSKL 414 E+ WPG + + Sbjct: 339 EESWPGVTSI 348
>PCTK2_RAT (O35831) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 150 bits (380), Expect = 9e-37 Identities = 70/132 (53%), Positives = 90/132 (68%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S VK + Q+L G+ Y H V+HRDLK N+L+N GELK+ DFGL+R P K Y Sbjct: 286 SMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTY 345 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 + VVTLWYR P++LLG+ EYST IDMW +GCI E+ S +PLF G D+L IFR+L Sbjct: 346 SNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLL 405 Query: 373 GTPNEDIWPGYS 408 GTP+++ WPG S Sbjct: 406 GTPSQETWPGVS 417
>PCTK2_MOUSE (Q8K0D0) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 150 bits (380), Expect = 9e-37 Identities = 70/132 (53%), Positives = 90/132 (68%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S VK + Q+L G+ Y H V+HRDLK N+L+N GELK+ DFGL+R P K Y Sbjct: 286 SMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTY 345 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 + VVTLWYR P++LLG+ EYST IDMW +GCI E+ S +PLF G D+L IFR+L Sbjct: 346 SNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLL 405 Query: 373 GTPNEDIWPGYS 408 GTP+++ WPG S Sbjct: 406 GTPSQETWPGVS 417
>PCTK2_HUMAN (Q00537) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 150 bits (380), Expect = 9e-37 Identities = 70/132 (53%), Positives = 90/132 (68%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S VK + Q+L G+ Y H V+HRDLK N+L+N GELK+ DFGL+R P K Y Sbjct: 286 SMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTY 345 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 + VVTLWYR P++LLG+ EYST IDMW +GCI E+ S +PLF G D+L IFR+L Sbjct: 346 SNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLL 405 Query: 373 GTPNEDIWPGYS 408 GTP+++ WPG S Sbjct: 406 GTPSQETWPGIS 417
>CC2H1_TRYCO (P54664) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 150 bits (380), Expect = 9e-37 Identities = 67/127 (52%), Positives = 91/127 (71%) Frame = +1 Query: 37 MLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVVTLW 216 M LL+GV++ H+ V+HRDLK N+L++ ELK+ DFGL R +G P+K YT VVTLW Sbjct: 108 MRSLLKGVRFCHERNVLHRDLKPPNLLISREKELKLADFGLGRAFGIPVKKYTHEVVTLW 167 Query: 217 YRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNEDIW 396 YR+P++LLG+ +Y T +D+WS+GCI AE+ PLF GK D DQL +IFR LGTP+ +W Sbjct: 168 YRSPDVLLGSTQYGTPVDIWSVGCIFAEMAIGAPLFAGKNDADQLLRIFRFLGTPSSQVW 227 Query: 397 PGYSKLP 417 P + P Sbjct: 228 PSMNLYP 234
>PCTK3_RAT (O35832) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 150 bits (379), Expect = 1e-36 Identities = 69/130 (53%), Positives = 90/130 (69%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK M QLL G+ Y H ++HRDLK N+L+N GELK+ DFGL+R P K Y+ V Sbjct: 219 VKIFMFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEV 278 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYR P++LLG+ EYST IDMW +GCI+ E+ + KPLF G ++L IFR+LGTP Sbjct: 279 VTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPLFPGSTVKEELHLIFRLLGTPT 338 Query: 385 EDIWPGYSKL 414 E+ WPG + + Sbjct: 339 EESWPGVTSI 348
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 150 bits (378), Expect = 2e-36 Identities = 67/130 (51%), Positives = 94/130 (72%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + Q+L+G+ + H V+HRDLK N+L+++ G +K+ DFGL+R +G P++ YT V Sbjct: 105 VKSYLYQILQGIIFCHARRVLHRDLKPQNLLIDSKGVIKLADFGLARAFGIPVRVYTHEV 164 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LLG+ YST +D+WS+G I AE+ SKKPLF G +IDQL +I + GTPN Sbjct: 165 VTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIASKKPLFHGDSEIDQLFRISELWGTPN 224 Query: 385 EDIWPGYSKL 414 ++WP L Sbjct: 225 NEVWPEVESL 234
>PCTK3_PONPY (Q5RD01) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 149 bits (375), Expect = 3e-36 Identities = 69/130 (53%), Positives = 88/130 (67%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S VK M QLL G+ Y H ++HRDLK N+L+N GELK+ DFGL+R P K Y Sbjct: 236 SMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTY 295 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 + VVTLWYR P++LLG+ EYST IDMW +GCI E+ + +PLF G ++L IFR+L Sbjct: 296 SNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLL 355 Query: 373 GTPNEDIWPG 402 GTP E+ WPG Sbjct: 356 GTPTEETWPG 365
>PCTK3_HUMAN (Q07002) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 149 bits (375), Expect = 3e-36 Identities = 69/130 (53%), Positives = 88/130 (67%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S VK M QLL G+ Y H ++HRDLK N+L+N GELK+ DFGL+R P K Y Sbjct: 236 SMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTY 295 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 + VVTLWYR P++LLG+ EYST IDMW +GCI E+ + +PLF G ++L IFR+L Sbjct: 296 SNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLL 355 Query: 373 GTPNEDIWPG 402 GTP E+ WPG Sbjct: 356 GTPTEETWPG 365
>AL2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22)| (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) Length = 384 Score = 148 bits (373), Expect = 6e-36 Identities = 69/132 (52%), Positives = 91/132 (68%), Gaps = 1/132 (0%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 V+ M QLL G+ Y+H V+HRDLK N+L+++ GELK+ DFGL+R P + Y+ V Sbjct: 150 VRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEV 209 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDI-DQLSKIFRMLGTP 381 VTLWYR P+ LLGA EYS+ +D+W GCI E+ +PLF G +I +QL KI+ +LG P Sbjct: 210 VTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVP 269 Query: 382 NEDIWPGYSKLP 417 ED WPG SKLP Sbjct: 270 TEDTWPGVSKLP 281
>BUR1_KLULA (Q6CRA9) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 645 Score = 148 bits (373), Expect = 6e-36 Identities = 71/141 (50%), Positives = 100/141 (70%), Gaps = 12/141 (8%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY-GSP-- 180 + ++VK +MLQLLEG+ Y+H N +HRD+KT+NIL+++ G +KI DFGL+R Y GSP Sbjct: 180 FGMADVKNIMLQLLEGINYIHCNKFLHRDIKTANILIDHKGVVKIADFGLARNYYGSPPN 239 Query: 181 LK---------PYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGK 333 LK YT +VVT WYRAPE++LG + Y+TA+D+W +GC+ AE KKP+ G+ Sbjct: 240 LKYPGGAGSGAKYTSVVVTRWYRAPEIVLGDRHYTTAVDIWGIGCVFAEFFEKKPILQGQ 299 Query: 334 RDIDQLSKIFRMLGTPNEDIW 396 DIDQ IF+++GTP+ D W Sbjct: 300 TDIDQGHVIFKLMGTPSMDEW 320
>PCTK1_MOUSE (Q04735) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) (CRK5) Length = 496 Score = 147 bits (370), Expect = 1e-35 Identities = 68/126 (53%), Positives = 87/126 (69%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + QLL G+ Y H V+HRDLK N+L+N GELK+ DFGL+R P K Y+ V Sbjct: 263 VKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEV 322 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYR P++LLG+ +YST IDMW +GCI E+ + +PLF G +QL IFR+LGTP Sbjct: 323 VTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPT 382 Query: 385 EDIWPG 402 E+ WPG Sbjct: 383 EETWPG 388
>PCTK1_HUMAN (Q00536) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 147 bits (370), Expect = 1e-35 Identities = 68/126 (53%), Positives = 87/126 (69%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + QLL G+ Y H V+HRDLK N+L+N GELK+ DFGL+R P K Y+ V Sbjct: 263 VKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEV 322 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYR P++LLG+ +YST IDMW +GCI E+ + +PLF G +QL IFR+LGTP Sbjct: 323 VTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPT 382 Query: 385 EDIWPG 402 E+ WPG Sbjct: 383 EETWPG 388
>BUR1_GIBZE (Q4I5U9) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 473 Score = 147 bits (370), Expect = 1e-35 Identities = 68/147 (46%), Positives = 99/147 (67%), Gaps = 11/147 (7%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY------ 171 + + ++KC MLQLLEG++YLHD+ ++HRD+K +N+L+NN G L+I DFGL+R Y Sbjct: 141 FKEPQIKCYMLQLLEGLRYLHDSRILHRDMKAANLLINNKGILQIADFGLARHYDGRTPE 200 Query: 172 -----GSPLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKR 336 G + YT LVVT WYR PELLL ++Y+ AID+W +GC+ E+L KP+ G+ Sbjct: 201 SGVPMGEGKRDYTGLVVTRWYRPPELLLQLRQYTPAIDVWGVGCVFGEMLYGKPILAGES 260 Query: 337 DIDQLSKIFRMLGTPNEDIWPGYSKLP 417 D QL I+ ++G+PNE+ P + LP Sbjct: 261 DAAQLDIIWDLMGSPNEENMPRWKSLP 287
>KC47_ORYSA (P29620) CDC2+/CDC28-related protein kinase R2 (EC 2.7.11.22)| Length = 424 Score = 146 bits (369), Expect = 2e-35 Identities = 64/135 (47%), Positives = 89/135 (65%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S ++ K + +L+G+ + H WV+HRD+K +N+L+ G+LK+ DFGL+R +GSP + + Sbjct: 114 SPADTKSYIQMMLKGLAFCHKKWVLHRDMKPNNLLIGADGQLKLADFGLARIFGSPERNF 173 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 T V WYRAPELL G K+Y +A+D+W+ GCI AELL ++P G DIDQL KIF Sbjct: 174 THQVFARWYRAPELLFGTKQYGSAVDIWAAGCIFAELLLRRPFLQGSSDIDQLGKIFAAF 233 Query: 373 GTPNEDIWPGYSKLP 417 GTP WP LP Sbjct: 234 GTPKSSQWPDMVYLP 248
>CD2L7_CAEEL (P46551) Putative cell division cycle 2-related protein kinase 7| (EC 2.7.11.22) Length = 730 Score = 145 bits (367), Expect = 3e-35 Identities = 66/135 (48%), Positives = 94/135 (69%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 +++ ++ L QLLEG+ Y+H+ +HRD+K SNIL+NN GELKI D GL+R + + Sbjct: 416 FNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESRL 475 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 YT V+TLWYR PELLLG + Y AID+WS GC++ EL ++KPLF+G + QL I ++ Sbjct: 476 YTNRVITLWYRPPELLLGDERYGPAIDVWSTGCMLGELFTRKPLFNGNNEFGQLELISKV 535 Query: 370 LGTPNEDIWPGYSKL 414 G+PN D WP ++L Sbjct: 536 CGSPNVDNWPELTEL 550
>CDC2B_ARATH (P25859) Cell division control protein 2 homolog B (EC 2.7.11.22)| (EC 2.7.11.23) Length = 309 Score = 145 bits (367), Expect = 3e-35 Identities = 72/138 (52%), Positives = 92/138 (66%), Gaps = 1/138 (0%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGEL-KICDFGLSRQYGSP 180 +P ++ LM QL +GV + H + V+HRDLK N+LL EL KI D GL R + P Sbjct: 112 KPLEPFLIQKLMFQLCKGVAHCHSHGVLHRDLKPQNLLLVKDKELLKIADLGLGRAFTVP 171 Query: 181 LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKI 360 LK YT +VTLWYRAPE+LLG+ YST +DMWS+GCI AE++ ++ LF G + QL I Sbjct: 172 LKSYTHEIVTLWYRAPEVLLGSTHYSTGVDMWSVGCIFAEMVRRQALFPGDSEFQQLLHI 231 Query: 361 FRMLGTPNEDIWPGYSKL 414 FR+LGTP E WPG S L Sbjct: 232 FRLLGTPTEQQWPGVSTL 249
>CCRK_RAT (Q4KM34) Cell cycle-related kinase (EC 2.7.11.22)| Length = 346 Score = 145 bits (366), Expect = 4e-35 Identities = 66/140 (47%), Positives = 99/140 (70%), Gaps = 1/140 (0%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP 180 ++P + ++VK + LL+GV + H N ++HRDLK +N+L++ G+LKI DFGL+R + Sbjct: 96 QRPLAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPD 155 Query: 181 L-KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSK 357 + YT V T WYRAPELL GA++Y +D+W++GCIM ELL+ PLF G+ DI+QL Sbjct: 156 GGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCC 215 Query: 358 IFRMLGTPNEDIWPGYSKLP 417 + R+LGTP+ +WP ++LP Sbjct: 216 VLRILGTPSPRVWPEITELP 235
>CCRK_MOUSE (Q9JHU3) Cell cycle-related kinase (EC 2.7.11.22)| (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) Length = 346 Score = 145 bits (366), Expect = 4e-35 Identities = 66/140 (47%), Positives = 99/140 (70%), Gaps = 1/140 (0%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP 180 ++P + ++VK + LL+GV + H N ++HRDLK +N+L++ G+LKI DFGL+R + Sbjct: 96 QRPLAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPD 155 Query: 181 L-KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSK 357 + YT V T WYRAPELL GA++Y +D+W++GCIM ELL+ PLF G+ DI+QL Sbjct: 156 GGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCC 215 Query: 358 IFRMLGTPNEDIWPGYSKLP 417 + R+LGTP+ +WP ++LP Sbjct: 216 VLRILGTPSPRVWPEITELP 235
>CTK1_YEAST (Q03957) CTD kinase subunit alpha (EC 2.7.11.23) (CTD kinase 58 kDa| subunit) (CTDK-I alpha subunit) Length = 528 Score = 145 bits (366), Expect = 4e-35 Identities = 67/135 (49%), Positives = 92/135 (68%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S S+ K L QLL G++YLHDN ++HRD+K SNIL++N G LKI DFGL+R+ S Y Sbjct: 279 SHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNLKITDFGLARKMNSRAD-Y 337 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 T V+TLWYR PELLLG Y T +DMW GC++ EL +K +F G +++Q+ IF+++ Sbjct: 338 TNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELFNKTAIFQGSNELEQIESIFKIM 397 Query: 373 GTPNEDIWPGYSKLP 417 GTP + WP +P Sbjct: 398 GTPTINSWPTLYDMP 412
>BUR1_ASHGO (Q75D46) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 753 Score = 145 bits (366), Expect = 4e-35 Identities = 72/145 (49%), Positives = 100/145 (68%), Gaps = 12/145 (8%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY-GSP--LK- 186 +++K +MLQ+LEG+ Y+H +HRD+KT+NILL++ G LKI DFGL+R Y G+P LK Sbjct: 176 ADIKNMMLQILEGINYIHCKKFMHRDIKTANILLDHKGILKIADFGLARNYYGAPPNLKY 235 Query: 187 --------PYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDI 342 YT +VVT WYRAPEL+LG K Y+TA+D+W +GC+ AE K+P+ GK DI Sbjct: 236 PGGAGTDAKYTSVVVTRWYRAPELVLGDKNYTTAVDIWGIGCVFAEFFEKRPILQGKTDI 295 Query: 343 DQLSKIFRMLGTPNEDIWPGYSKLP 417 DQ IF+++GTP++ W LP Sbjct: 296 DQGHVIFKLMGTPSDSDWQLARYLP 320
>BUR1_YEAST (P23293) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) (Suppressor of GPA1-Vall50 mutation protein 1) (Bypass UAS requirement protein 1) Length = 657 Score = 145 bits (366), Expect = 4e-35 Identities = 72/145 (49%), Positives = 98/145 (67%), Gaps = 13/145 (8%) Frame = +1 Query: 22 EVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY---------- 171 ++K +MLQ+LEG+ Y+H +HRD+KT+NIL+++ G LK+ DFGL+R Y Sbjct: 171 DIKNMMLQILEGLNYIHCAKFMHRDIKTANILIDHNGVLKLADFGLARLYYGCPPNLKYP 230 Query: 172 ---GSPLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDI 342 GS K YT +VVT WYRAPEL+LG K+Y+TA+D+W +GC+ AE KKP+ GK DI Sbjct: 231 GGAGSGAK-YTSVVVTRWYRAPELVLGDKQYTTAVDIWGVGCVFAEFFEKKPILQGKTDI 289 Query: 343 DQLSKIFRMLGTPNEDIWPGYSKLP 417 DQ IF++LGTP E+ W LP Sbjct: 290 DQGHVIFKLLGTPTEEDWAVARYLP 314
>BUR1_CANGA (Q6FQ83) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 667 Score = 144 bits (364), Expect = 6e-35 Identities = 70/145 (48%), Positives = 99/145 (68%), Gaps = 12/145 (8%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY-GSPLK--- 186 +++K +M Q+LEGV ++H + +HRD+KT+N+L+++ G LK+ DFGL+RQY GSP Sbjct: 182 ADIKNMMKQILEGVNFIHCSKFMHRDIKTANLLIDHNGVLKLADFGLARQYYGSPPNIKF 241 Query: 187 --------PYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDI 342 YT +VVT WYRAPEL+LG K Y+TA+D+W +GC+ AE KKP+ GK DI Sbjct: 242 PGSAGSGAKYTSVVVTRWYRAPELVLGDKYYTTAVDIWGVGCVFAEFFEKKPILQGKTDI 301 Query: 343 DQLSKIFRMLGTPNEDIWPGYSKLP 417 DQ IF+++GTP+E W LP Sbjct: 302 DQGHVIFKLMGTPDERTWELAKYLP 326
>BUR1_DEBHA (Q6BV06) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 608 Score = 144 bits (362), Expect = 1e-34 Identities = 70/144 (48%), Positives = 92/144 (63%), Gaps = 11/144 (7%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY-GSPLK--- 186 S +KC M QLL G++Y+H+ +HRD+K +NIL++ G LKI DFGL+R Y GSP K Sbjct: 149 SHIKCFMEQLLHGIQYIHEQMFLHRDIKAANILIDRNGTLKIADFGLARVYHGSPPKFMS 208 Query: 187 -------PYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDID 345 YT LVVT WYR PELLLG + Y+TA+DMW +GC+ EL ++KP+ GK D Sbjct: 209 GPGGGERAYTGLVVTRWYRPPELLLGERRYTTAVDMWGIGCVFGELFTRKPILVGKTDSH 268 Query: 346 QLSKIFRMLGTPNEDIWPGYSKLP 417 Q IF ++G PN W + LP Sbjct: 269 QAQLIFDLVGPPNSISWSEATSLP 292
>CRK1_LEIME (Q06309) Cell division protein kinase 2 homolog CRK1 (EC 2.7.11.23)| Length = 301 Score = 143 bits (361), Expect = 1e-34 Identities = 63/131 (48%), Positives = 89/131 (67%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 ++ M LL GV + H V+HRDLK N+L++ ELK+ DFGL R + P++ +T V Sbjct: 104 IQHFMRDLLRGVAFCHQRSVLHRDLKPQNLLISREKELKLGDFGLGRSFAIPVRKFTNEV 163 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYR P++LLG+ +Y +D+WS+GCI +E+ + PLF GK D DQL +IFR LGTPN Sbjct: 164 VTLWYRPPDVLLGSMQYGPPVDVWSVGCIFSEMATGTPLFAGKNDADQLMRIFRFLGTPN 223 Query: 385 EDIWPGYSKLP 417 +WP ++ P Sbjct: 224 NRVWPSMNQYP 234
>CDK2_MOUSE (P97377) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 346 Score = 143 bits (360), Expect = 2e-34 Identities = 72/179 (40%), Positives = 101/179 (56%), Gaps = 48/179 (26%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K + QLL+G+ + H + V+HRDLK N+L+N G +K+ DFGL+R +G P++ YT V Sbjct: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEV 163 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAEL--------------------------- 303 VTLWYRAPE+LLG K YSTA+D+WSLGCI AE+ Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVCTQHHAKCCGEHRRNGRHSLCPLC 223 Query: 304 ---------------------LSKKPLFDGKRDIDQLSKIFRMLGTPNEDIWPGYSKLP 417 ++++ LF G +IDQL +IFR LGTP+E +WPG + +P Sbjct: 224 SYLEVAASQGGGMTAVSAPHPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 282
>PCTK1_RAT (Q63686) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 143 bits (360), Expect = 2e-34 Identities = 67/126 (53%), Positives = 85/126 (67%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + QLL G+ Y H V+HRDLK N+L+N GELK+ DFGL+ P K Y+ V Sbjct: 263 VKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLAYAKSIPTKTYSNEV 322 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYR P++LLG+ +YS IDMW +GCI E+ + +PLF G +QL IFR+LGTP Sbjct: 323 VTLWYRPPDILLGSTDYSGQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPT 382 Query: 385 EDIWPG 402 ED WPG Sbjct: 383 EDTWPG 388
>CDK8_DROME (Q9VT57) Cell division protein kinase 8 (EC 2.7.11.22) (EC| 2.7.11.23) (DmCdk8) Length = 454 Score = 142 bits (359), Expect = 2e-34 Identities = 70/147 (47%), Positives = 97/147 (65%), Gaps = 16/147 (10%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILL----NNCGELKICDFGLSRQYGSPLKPY 192 VK L+ Q+L+G+ YLH NWV+HRDLK +NIL+ N G +KI D G +R + +PLKP Sbjct: 128 VKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPL 187 Query: 193 TQL---VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRD-------- 339 L VVT WYRAPELLLGA+ Y+ AID+W++GCI AELL+ +P+F +++ Sbjct: 188 ADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPY 247 Query: 340 -IDQLSKIFRMLGTPNEDIWPGYSKLP 417 DQL +IF ++G P + W K+P Sbjct: 248 HHDQLDRIFNVMGFPQDKDWEDIKKMP 274
>CC2H3_TRYBB (P54666) Cell division control protein 2 homolog 3 (EC 2.7.11.22)| Length = 311 Score = 142 bits (359), Expect = 2e-34 Identities = 70/138 (50%), Positives = 95/138 (68%), Gaps = 2/138 (1%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 ++ + +K ++ QLLEG+ + H + ++HRDLK +NIL+ +KI DFGL+R + P+ Sbjct: 117 FTGTTLKKIIYQLLEGLSFCHRHRIVHRDLKPANILVTTDNSVKIADFGLARAFQIPMHT 176 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 YT VVTLWYRAPE+LLG K Y+ A+DMWS+GCI AEL K LF G +I QL +IF++ Sbjct: 177 YTHEVVTLWYRAPEILLGEKHYTPAVDMWSIGCIFAELARGKVLFRGDSEIGQLFEIFQV 236 Query: 370 LGTP--NEDIWPGYSKLP 417 LGTP E W G S LP Sbjct: 237 LGTPMDAEGSWLGVSSLP 254
>UME5_YEAST (P39073) Meiotic mRNA stability protein kinase UME5 (EC 2.7.11.23)| Length = 541 Score = 142 bits (358), Expect = 3e-34 Identities = 70/145 (48%), Positives = 101/145 (69%), Gaps = 14/145 (9%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP-YT-- 195 V+ +M QLL+GV YLH NWV+HRDLK +NI++ G +KI D GL+R++ + L+ YT Sbjct: 249 VRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHNMLQTLYTGD 308 Query: 196 QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKR-----------DI 342 ++VVT+WYRAPELLLGA+ Y+ A+D+WS+GCI AEL+ +P+F G+ + Sbjct: 309 KVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTVPFQV 368 Query: 343 DQLSKIFRMLGTPNEDIWPGYSKLP 417 +QL +I +LGTP++ IWP K P Sbjct: 369 NQLQRILEVLGTPDQKIWPYLEKYP 393
>CDK2_ENTHI (Q04770) Cell division protein kinase 2 homolog (EC 2.7.11.22)| Length = 291 Score = 142 bits (358), Expect = 3e-34 Identities = 67/133 (50%), Positives = 93/133 (69%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQ 198 +E + ++ Q+L+G+ + H + ++HRD+K NIL+N G +K+ +FGL+R + YT Sbjct: 100 NETRSIVYQILQGLAFCHYHQILHRDMKPQNILINKNGTIKLGEFGLARLTTINDRKYTS 159 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 VVTLWYRAPE+LLGA +Y AID+WS I EL++K+ LF G+ IDQL KIF LGT Sbjct: 160 EVVTLWYRAPEILLGATQYGGAIDIWSTAAIFGELINKEELFKGRCKIDQLFKIFSQLGT 219 Query: 379 PNEDIWPGYSKLP 417 P EDIW G +KLP Sbjct: 220 PTEDIWNGVTKLP 232
>CDC2C_ANTMA (Q38774) Cell division control protein 2 homolog C (EC 2.7.11.22)| (EC 2.7.11.23) Length = 305 Score = 140 bits (352), Expect = 2e-33 Identities = 68/138 (49%), Positives = 96/138 (69%), Gaps = 1/138 (0%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLN-NCGELKICDFGLSRQYGSP 180 +P +++ + QL +GV + H + V+HRDLK N+LL+ + G LKI D GL+R + P Sbjct: 108 RPLPPQQIQSFLFQLCKGVSHCHAHGVLHRDLKPQNLLLDKDKGVLKIADLGLARAFTVP 167 Query: 181 LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKI 360 LK YT +VTL YRAPE+LLG+ YSTA+DM S+GCI AE++ ++ LF G + QL I Sbjct: 168 LKSYTHEIVTLSYRAPEVLLGSSHYSTAVDMSSVGCIFAEMVRRQALFPGDSEFQQLLHI 227 Query: 361 FRMLGTPNEDIWPGYSKL 414 FR+LGTP+++ WPG S L Sbjct: 228 FRLLGTPSDEQWPGVSSL 245
>CD2L6_HUMAN (Q9BWU1) Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22)| (CDC2-related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11) Length = 502 Score = 139 bits (351), Expect = 2e-33 Identities = 71/150 (47%), Positives = 98/150 (65%), Gaps = 16/150 (10%) Frame = +1 Query: 16 QSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN----CGELKICDFGLSRQYGSPL 183 +S VK L+ Q+L+G+ YLH NWV+HRDLK +NIL+ G +KI D G +R + SPL Sbjct: 125 RSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPL 184 Query: 184 KPYTQL---VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRD----- 339 KP L VVT WYRAPELLLGA+ Y+ AID+W++GCI AELL+ +P+F +++ Sbjct: 185 KPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTS 244 Query: 340 ----IDQLSKIFRMLGTPNEDIWPGYSKLP 417 DQL +IF ++G P + W K+P Sbjct: 245 NPFHHDQLDRIFSVMGFPADKDWEDIRKMP 274
>CD2L6_MOUSE (Q8BWD8) Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22)| (CDC2-related protein kinase 6) Length = 501 Score = 139 bits (351), Expect = 2e-33 Identities = 71/150 (47%), Positives = 98/150 (65%), Gaps = 16/150 (10%) Frame = +1 Query: 16 QSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN----CGELKICDFGLSRQYGSPL 183 +S VK L+ Q+L+G+ YLH NWV+HRDLK +NIL+ G +KI D G +R + SPL Sbjct: 125 RSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPL 184 Query: 184 KPYTQL---VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRD----- 339 KP L VVT WYRAPELLLGA+ Y+ AID+W++GCI AELL+ +P+F +++ Sbjct: 185 KPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTS 244 Query: 340 ----IDQLSKIFRMLGTPNEDIWPGYSKLP 417 DQL +IF ++G P + W K+P Sbjct: 245 NPFHHDQLDRIFSVMGFPADKDWEDIRKMP 274
>CDK6_MOUSE (Q64261) Cell division protein kinase 6 (EC 2.7.11.22)| (Serine/threonine-protein kinase PLSTIRE) (CRK2) Length = 326 Score = 139 bits (351), Expect = 2e-33 Identities = 66/131 (50%), Positives = 92/131 (70%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K +M QLL G+ +LH + V+HRDLK NIL+ + G++K+ DFGL+R Y + T +V Sbjct: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVV 180 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LL + Y+T +D+WS+GCI AE+ +KPLF G D+DQL KI ++G P Sbjct: 181 VTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLPG 239 Query: 385 EDIWPGYSKLP 417 E+ WP LP Sbjct: 240 EEDWPRDVALP 250
>CDK6_HUMAN (Q00534) Cell division protein kinase 6 (EC 2.7.11.22)| (Serine/threonine-protein kinase PLSTIRE) Length = 326 Score = 139 bits (351), Expect = 2e-33 Identities = 66/131 (50%), Positives = 92/131 (70%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K +M QLL G+ +LH + V+HRDLK NIL+ + G++K+ DFGL+R Y + T +V Sbjct: 122 IKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVV 180 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LL + Y+T +D+WS+GCI AE+ +KPLF G D+DQL KI ++G P Sbjct: 181 VTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPG 239 Query: 385 EDIWPGYSKLP 417 E+ WP LP Sbjct: 240 EEDWPRDVALP 250
>CDK8_HUMAN (P49336) Cell division protein kinase 8 (EC 2.7.11.22) (EC| 2.7.11.23) (Protein kinase K35) Length = 464 Score = 139 bits (350), Expect = 3e-33 Identities = 70/147 (47%), Positives = 96/147 (65%), Gaps = 16/147 (10%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNN----CGELKICDFGLSRQYGSPLKPY 192 VK L+ Q+L+G+ YLH NWV+HRDLK +NIL+ G +KI D G +R + SPLKP Sbjct: 128 VKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPL 187 Query: 193 TQL---VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRD-------- 339 L VVT WYRAPELLLGA+ Y+ AID+W++GCI AELL+ +P+F +++ Sbjct: 188 ADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPY 247 Query: 340 -IDQLSKIFRMLGTPNEDIWPGYSKLP 417 DQL +IF ++G P + W K+P Sbjct: 248 HHDQLDRIFNVMGFPADKDWEDIKKMP 274
>CDK4_RAT (P35426) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) Length = 303 Score = 138 bits (347), Expect = 6e-33 Identities = 68/131 (51%), Positives = 90/131 (68%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K LM Q L G+ +LH N ++HRDLK NIL+ + G +K+ DFGL+R Y + T +V Sbjct: 117 IKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMA-LTPVV 175 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LL + Y+T +DMWS+GCI AE+ +KPLF G + DQL KIF ++G P Sbjct: 176 VTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 Query: 385 EDIWPGYSKLP 417 ED WP LP Sbjct: 235 EDDWPREVSLP 245
>CDK4_MOUSE (P30285) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) (CRK3) Length = 303 Score = 138 bits (347), Expect = 6e-33 Identities = 68/131 (51%), Positives = 90/131 (68%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K LM Q L G+ +LH N ++HRDLK NIL+ + G +K+ DFGL+R Y + T +V Sbjct: 117 IKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMA-LTPVV 175 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LL + Y+T +DMWS+GCI AE+ +KPLF G + DQL KIF ++G P Sbjct: 176 VTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 Query: 385 EDIWPGYSKLP 417 ED WP LP Sbjct: 235 EDDWPREVSLP 245
>CRK1_SCHPO (Q12126) Serine/threonine-protein kinase crk1 (EC 2.7.11.23)| (Mitotic catastrophe suppressor 6) Length = 335 Score = 138 bits (347), Expect = 6e-33 Identities = 61/136 (44%), Positives = 92/136 (67%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 + + +K M+ LL G+ ++H +++HRDLK +N+L+++ G LK+ DFGLSR +G+P Sbjct: 105 FQPAHIKSWMVMLLRGLHHIHSRFILHRDLKPNNLLISSDGVLKLADFGLSRDFGTPSHM 164 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 Q V+T WYR PEL +G + Y T +DMWS+GCI AEL+ + P G+ D+DQL+ IFR Sbjct: 165 SHQ-VITRWYRPPELFMGCRSYGTGVDMWSVGCIFAELMLRTPYLPGESDLDQLNVIFRA 223 Query: 370 LGTPNEDIWPGYSKLP 417 LGTP ++ +LP Sbjct: 224 LGTPEPEVIKSMQQLP 239
>PRK1_SCHPO (O13958) Serine/threonine-protein kinase prk1 (EC 2.7.11.22)| (Suppressor of RNA polymerase B srb10) Length = 352 Score = 137 bits (346), Expect = 8e-33 Identities = 65/147 (44%), Positives = 94/147 (63%), Gaps = 14/147 (9%) Frame = +1 Query: 19 SEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY-- 192 S +K ++ Q++ GV YLH+NW++HRDLK +NI++ G++KI D GL R P+ P+ Sbjct: 115 SILKSILWQIINGVAYLHENWIMHRDLKPANIMITATGKVKIGDLGLGRLIRDPILPFYS 174 Query: 193 -TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKR----------- 336 ++VVT+WYRAPELLLGA +Y+ AID+W++GCI E+L+ PLF G Sbjct: 175 SDRVVVTIWYRAPELLLGAHDYTPAIDVWAIGCIYGEMLALSPLFKGDEIKMEDKKVVPF 234 Query: 337 DIDQLSKIFRMLGTPNEDIWPGYSKLP 417 Q+ +I +LGTP E+ WPG P Sbjct: 235 QSTQMLRIMELLGTPTEERWPGLKNYP 261
>CDK4_PIG (P79432) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 303 Score = 137 bits (346), Expect = 8e-33 Identities = 68/131 (51%), Positives = 90/131 (68%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K LM Q L G+ +LH N ++HRDLK NIL+ + G +K+ DFGL+R Y + T +V Sbjct: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVV 175 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LL + Y+T +DMWS+GCI AE+ +KPLF G + DQL KIF ++G P Sbjct: 176 VTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 Query: 385 EDIWPGYSKLP 417 ED WP LP Sbjct: 235 EDDWPRDVSLP 245
>CDK4_HUMAN (P11802) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) Length = 303 Score = 137 bits (346), Expect = 8e-33 Identities = 68/131 (51%), Positives = 90/131 (68%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K LM Q L G+ +LH N ++HRDLK NIL+ + G +K+ DFGL+R Y + T +V Sbjct: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVV 175 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LL + Y+T +DMWS+GCI AE+ +KPLF G + DQL KIF ++G P Sbjct: 176 VTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 Query: 385 EDIWPGYSKLP 417 ED WP LP Sbjct: 235 EDDWPRDVSLP 245
>KIN28_YEAST (P06242) Serine/threonine-protein kinase KIN28 (EC 2.7.11.23)| Length = 306 Score = 137 bits (346), Expect = 8e-33 Identities = 63/133 (47%), Positives = 91/133 (68%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 ++ +++K ML L GV + H N+++HRDLK +N+L + G++K+ DFGL+R +P + Sbjct: 101 FTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEI 160 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 T VVT WYRAPELL GAK Y++AID+WS+G I AEL+ + P G+ D+DQ+ FR Sbjct: 161 LTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRA 220 Query: 370 LGTPNEDIWPGYS 408 LGTP + WP S Sbjct: 221 LGTPTDRDWPEVS 233
>BUR1_CANAL (Q9Y7W4) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 746 Score = 135 bits (341), Expect = 3e-32 Identities = 65/143 (45%), Positives = 93/143 (65%), Gaps = 11/143 (7%) Frame = +1 Query: 22 EVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY---------- 171 ++KC+M QLL+G++Y+H+ +HRD+K +NIL+ G LKI DFGL+R Y Sbjct: 155 QIKCIMQQLLKGIQYVHNQKFLHRDIKAANILIGQDGVLKIADFGLARIYHGNVPRLGMG 214 Query: 172 -GSPLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQ 348 G K YT LVVT WYR PE+LLG ++Y+TA+D+W +GC+ AEL + KP+ GK D Q Sbjct: 215 PGGGEKAYTGLVVTRWYRPPEILLGERKYTTAVDLWGIGCVFAELFTGKPILVGKSDSHQ 274 Query: 349 LSKIFRMLGTPNEDIWPGYSKLP 417 +F ++G+P W +KLP Sbjct: 275 AQIVFELVGSPL--TWTDAAKLP 295
>CDK4_XENLA (Q91727) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 319 Score = 135 bits (340), Expect = 4e-32 Identities = 66/131 (50%), Positives = 92/131 (70%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K LM Q L G+++LH N ++HRDLK NIL+ + G++K+ DFGL+R Y + T +V Sbjct: 117 IKDLMKQFLSGLEFLHLNCIVHRDLKPENILVTSGGQVKLADFGLARIYSCQMA-LTPVV 175 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 VTLWYRAPE+LL + Y+T +D+WS GCI AE+ +KPLF G + DQL KIF ++G P+ Sbjct: 176 VTLWYRAPEVLLQST-YATPVDVWSAGCIFAEMFKRKPLFCGNSEADQLCKIFDIIGLPS 234 Query: 385 EDIWPGYSKLP 417 E+ WP LP Sbjct: 235 EEEWPVDVTLP 245
>MMK1_MEDSA (Q07176) Mitogen-activated protein kinase homolog MMK1 (EC| 2.7.11.24) (MAP kinase MSK7) (MAP kinase ERK1) Length = 387 Score = 134 bits (337), Expect = 9e-32 Identities = 65/129 (50%), Positives = 89/129 (68%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S+ + + Q+L G+KY+H V+HRDLK SN+LLN +LKICDFGL+R S Sbjct: 151 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSET 209 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 T+ VVT WYRAPELLL + +Y+ AID+WS+GCI EL+ +KPLF G+ + QL + Sbjct: 210 DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLM 269 Query: 364 RMLGTPNED 390 ++GTP+ED Sbjct: 270 ELIGTPSED 278
>CC2H2_TRYBB (P54665) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 345 Score = 133 bits (334), Expect = 2e-31 Identities = 64/133 (48%), Positives = 90/133 (67%), Gaps = 1/133 (0%) Frame = +1 Query: 22 EVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGEL-KICDFGLSRQYGSPLKPYTQ 198 +++ +M QLL G+ H +HRD+K SNIL++ + K+ DFGL R + PL+ YT Sbjct: 144 KLRRIMFQLLLGLHECHSRRFVHRDIKPSNILIDRKESVVKLADFGLGRAFRVPLQTYTT 203 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 V+TLWYRAPE+LLG K+Y A+D+WS+GC+ AEL ++ LF G I+QL IF++LGT Sbjct: 204 EVMTLWYRAPEVLLGDKQYLPAVDVWSMGCVFAELARRRSLFAGDTAINQLFSIFQLLGT 263 Query: 379 PNEDIWPGYSKLP 417 P E W G + LP Sbjct: 264 PTEATWRGVTSLP 276
>MPK3_ARATH (Q39023) Mitogen-activated protein kinase homolog 3 (EC 2.7.11.24)| (MAP kinase 3) (AtMPK3) Length = 370 Score = 132 bits (333), Expect = 3e-31 Identities = 66/128 (51%), Positives = 88/128 (68%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S+ + + QLL G+KY+H +IHRDLK SN+LLN +LKICDFGL+R S Sbjct: 134 QSLSEEHCQYFLYQLLRGLKYIHSANIIHRDLKPSNLLLNANCDLKICDFGLARPT-SEN 192 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 T+ VVT WYRAPELLL + +Y+ AID+WS+GCI EL+++KPLF GK + Q+ + Sbjct: 193 DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMNRKPLFPGKDHVHQMRLLT 252 Query: 364 RMLGTPNE 387 +LGTP E Sbjct: 253 ELLGTPTE 260
>MPK6_ARATH (Q39026) Mitogen-activated protein kinase homolog 6 (EC 2.7.11.24)| (MAP kinase 6) (AtMPK6) Length = 395 Score = 132 bits (332), Expect = 3e-31 Identities = 64/129 (49%), Positives = 89/129 (68%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S+ + + Q+L G+KY+H V+HRDLK SN+LLN +LKICDFGL+R S Sbjct: 159 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSES 217 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 T+ VVT WYRAPELLL + +Y+ AID+WS+GCI EL+ +KPLF G+ + QL + Sbjct: 218 DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLM 277 Query: 364 RMLGTPNED 390 ++GTP+E+ Sbjct: 278 ELIGTPSEE 286
>MAPK_PEA (Q06060) Mitogen-activated protein kinase homolog D5 (EC 2.7.11.24)| Length = 394 Score = 132 bits (331), Expect = 4e-31 Identities = 64/128 (50%), Positives = 88/128 (68%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S+ + + Q+L G+KY+H V+HRDLK SN+LLN +LKICDFGL+R S Sbjct: 158 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSET 216 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 T+ VVT WYRAPELLL + +Y+ AID+WS+GCI EL+ +KPLF G+ + QL + Sbjct: 217 DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLM 276 Query: 364 RMLGTPNE 387 ++GTP+E Sbjct: 277 ELIGTPSE 284
>ERKA_DROME (P40417) Mitogen-activated protein kinase ERK-A (EC 2.7.11.24)| (Extracellular-regulated kinase A) (Protein rolled) Length = 376 Score = 131 bits (330), Expect = 6e-31 Identities = 64/133 (48%), Positives = 91/133 (68%), Gaps = 4/133 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + Q+L G+KY+H V+HRDLK SN+LLN +LKICDFGL+R P Sbjct: 132 QRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLAR-IADPE 190 Query: 184 KPYT----QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 +T + V T WYRAPE++L +K Y+ +ID+WS+GCI+AE+LS +P+F GK +DQL Sbjct: 191 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 250 Query: 352 SKIFRMLGTPNED 390 + I +LG+P+ D Sbjct: 251 NHILGVLGSPSRD 263
>NTF4_TOBAC (Q40532) Mitogen-activated protein kinase homolog NTF4 (EC| 2.7.11.24) (P45) Length = 393 Score = 131 bits (330), Expect = 6e-31 Identities = 64/128 (50%), Positives = 88/128 (68%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S+ + + Q+L G+KY+H V+HRDLK SN+LLN +LKICDFGL+R S Sbjct: 156 QGLSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSET 214 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 T+ VVT WYRAPELLL + +Y+ AID+WS+GCI EL+ +KPLF G+ + QL + Sbjct: 215 DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLM 274 Query: 364 RMLGTPNE 387 ++GTP+E Sbjct: 275 ELIGTPSE 282
>MK01_XENLA (P26696) Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Myelin| xP42 protein kinase) (Myelin basic protein kinase) (MBP kinase) (M phase MAP kinase) Length = 361 Score = 130 bits (327), Expect = 1e-30 Identities = 63/133 (47%), Positives = 92/133 (69%), Gaps = 4/133 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + Q+L G+KY+H V+HRDLK SN+LLN +LKICDFGL+R P Sbjct: 122 QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPD 180 Query: 184 KPYT----QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 +T + V T WYRAPE++L +K Y+ +ID+WS+GCI+AE+LS +P+F GK +DQL Sbjct: 181 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 240 Query: 352 SKIFRMLGTPNED 390 + I +LG+P+++ Sbjct: 241 NHILGILGSPSQE 253
>MK01_HUMAN (P28482) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 130 bits (327), Expect = 1e-30 Identities = 63/133 (47%), Positives = 92/133 (69%), Gaps = 4/133 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + Q+L G+KY+H V+HRDLK SN+LLN +LKICDFGL+R P Sbjct: 118 QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPD 176 Query: 184 KPYT----QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 +T + V T WYRAPE++L +K Y+ +ID+WS+GCI+AE+LS +P+F GK +DQL Sbjct: 177 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 236 Query: 352 SKIFRMLGTPNED 390 + I +LG+P+++ Sbjct: 237 NHILGILGSPSQE 249
>MK01_BOVIN (P46196) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 130 bits (327), Expect = 1e-30 Identities = 63/133 (47%), Positives = 92/133 (69%), Gaps = 4/133 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + Q+L G+KY+H V+HRDLK SN+LLN +LKICDFGL+R P Sbjct: 118 QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPD 176 Query: 184 KPYT----QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 +T + V T WYRAPE++L +K Y+ +ID+WS+GCI+AE+LS +P+F GK +DQL Sbjct: 177 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 236 Query: 352 SKIFRMLGTPNED 390 + I +LG+P+++ Sbjct: 237 NHILGILGSPSQE 249
>MK03_HUMAN (P27361) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) Length = 379 Score = 130 bits (327), Expect = 1e-30 Identities = 62/133 (46%), Positives = 92/133 (69%), Gaps = 4/133 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + Q+L G+KY+H V+HRDLK SN+L+N +LKICDFGL+R P Sbjct: 136 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPE 194 Query: 184 KPYT----QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 +T + V T WYRAPE++L +K Y+ +ID+WS+GCI+AE+LS +P+F GK +DQL Sbjct: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 Query: 352 SKIFRMLGTPNED 390 + I +LG+P+++ Sbjct: 255 NHILGILGSPSQE 267
>MK01_RAT (P63086) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 130 bits (327), Expect = 1e-30 Identities = 63/133 (47%), Positives = 92/133 (69%), Gaps = 4/133 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + Q+L G+KY+H V+HRDLK SN+LLN +LKICDFGL+R P Sbjct: 116 QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPD 174 Query: 184 KPYT----QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 +T + V T WYRAPE++L +K Y+ +ID+WS+GCI+AE+LS +P+F GK +DQL Sbjct: 175 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 234 Query: 352 SKIFRMLGTPNED 390 + I +LG+P+++ Sbjct: 235 NHILGILGSPSQE 247
>MK01_MOUSE (P63085) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 130 bits (327), Expect = 1e-30 Identities = 63/133 (47%), Positives = 92/133 (69%), Gaps = 4/133 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + Q+L G+KY+H V+HRDLK SN+LLN +LKICDFGL+R P Sbjct: 116 QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPD 174 Query: 184 KPYT----QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 +T + V T WYRAPE++L +K Y+ +ID+WS+GCI+AE+LS +P+F GK +DQL Sbjct: 175 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 234 Query: 352 SKIFRMLGTPNED 390 + I +LG+P+++ Sbjct: 235 NHILGILGSPSQE 247
>MK03_RAT (P21708) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) (MNK1) Length = 380 Score = 130 bits (327), Expect = 1e-30 Identities = 62/133 (46%), Positives = 92/133 (69%), Gaps = 4/133 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + Q+L G+KY+H V+HRDLK SN+L+N +LKICDFGL+R P Sbjct: 137 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPE 195 Query: 184 KPYT----QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 +T + V T WYRAPE++L +K Y+ +ID+WS+GCI+AE+LS +P+F GK +DQL Sbjct: 196 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 255 Query: 352 SKIFRMLGTPNED 390 + I +LG+P+++ Sbjct: 256 NHILGILGSPSQE 268
>MK03_MOUSE (Q63844) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) (MNK1) Length = 380 Score = 130 bits (327), Expect = 1e-30 Identities = 62/133 (46%), Positives = 92/133 (69%), Gaps = 4/133 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + Q+L G+KY+H V+HRDLK SN+L+N +LKICDFGL+R P Sbjct: 137 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPE 195 Query: 184 KPYT----QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 +T + V T WYRAPE++L +K Y+ +ID+WS+GCI+AE+LS +P+F GK +DQL Sbjct: 196 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 255 Query: 352 SKIFRMLGTPNED 390 + I +LG+P+++ Sbjct: 256 NHILGILGSPSQE 268
>SUR1_CAEEL (P39745) Mitogen-activated protein kinase mpk-1 (EC 2.7.11.24) (MAP| kinase sur-1) Length = 444 Score = 129 bits (324), Expect = 3e-30 Identities = 64/131 (48%), Positives = 90/131 (68%), Gaps = 4/131 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S V + Q+L G+KY+H V+HRDLK SN+LLN +LKICDFGL+R P Sbjct: 190 QKLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VTDPQ 248 Query: 184 KPYT----QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 +T + V T WYRAPE++L +K Y+ +ID+WS+GCI+AE+LS +PLF GK +DQL Sbjct: 249 TDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQL 308 Query: 352 SKIFRMLGTPN 384 + I ++G+P+ Sbjct: 309 NLILAVVGSPS 319
>MHK_ARATH (P43294) Serine/threonine-protein kinase MHK (EC 2.7.11.22)| Length = 443 Score = 129 bits (324), Expect = 3e-30 Identities = 63/133 (47%), Positives = 93/133 (69%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP 180 ++P+S+ E++ M Q+L+G+ ++H N HRDLK N+L+ N LKI DFGL+R+ S Sbjct: 102 ERPFSEGEIRSFMSQMLQGLAHMHKNGYFHRDLKPENLLVTN-NILKIADFGLAREVAS- 159 Query: 181 LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKI 360 + PYT+ V T WYRAPE+LL + Y+ A+DMW++G I+AEL + PLF G+ +IDQL KI Sbjct: 160 MPPYTEYVSTRWYRAPEVLLQSSLYTPAVDMWAVGAILAELYALTPLFPGESEIDQLYKI 219 Query: 361 FRMLGTPNEDIWP 399 +LG P+ +P Sbjct: 220 CCVLGKPDWTTFP 232
>CDK9_XENTR (Q6GLD8) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 376 Score = 129 bits (323), Expect = 4e-30 Identities = 59/138 (42%), Positives = 88/138 (63%), Gaps = 4/138 (2%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYG----S 177 ++ SE+K +M LL G+ Y+H N ++HRD+K +N+L+ G LK+ DFGL+R + S Sbjct: 125 FTLSEIKKVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 184 Query: 178 PLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSK 357 YT VVTLWYR PELLLG ++Y ID+W GCIMAE+ ++ P+ G + QL+ Sbjct: 185 QPNKYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLTL 244 Query: 358 IFRMLGTPNEDIWPGYSK 411 I ++ G+ ++WP K Sbjct: 245 ISQLCGSITPEVWPNVDK 262
>CDK9A_XENLA (Q4V862) Cell division protein kinase 9-A (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9-A) Length = 376 Score = 129 bits (323), Expect = 4e-30 Identities = 59/138 (42%), Positives = 88/138 (63%), Gaps = 4/138 (2%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYG----S 177 ++ SE+K +M LL G+ Y+H N ++HRD+K +N+L+ G LK+ DFGL+R + S Sbjct: 125 FTLSEIKKVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 184 Query: 178 PLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSK 357 YT VVTLWYR PELLLG ++Y ID+W GCIMAE+ ++ P+ G + QL+ Sbjct: 185 QPNKYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLTL 244 Query: 358 IFRMLGTPNEDIWPGYSK 411 I ++ G+ ++WP K Sbjct: 245 ISQLCGSITPEVWPNVDK 262
>NTF3_TOBAC (Q40517) Mitogen-activated protein kinase homolog NTF3 (EC| 2.7.11.24) (P43) Length = 372 Score = 129 bits (323), Expect = 4e-30 Identities = 63/129 (48%), Positives = 84/129 (65%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + QLL G+KYLH ++HRDLK N+L+N +LKICDFGL+R Sbjct: 128 QTLSNDHCQYFLFQLLRGLKYLHSANILHRDLKPGNLLINANCDLKICDFGLARTSSGKD 187 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 + T+ VVT WYRAPELLL Y T+ID+WS+GCI AELL +KP+F G ++QL I Sbjct: 188 QFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAELLGRKPVFPGTECLNQLKLII 247 Query: 364 RMLGTPNED 390 +LG+ E+ Sbjct: 248 NILGSQREE 256
>NLK_MOUSE (O54949) Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like| kinase) Length = 515 Score = 129 bits (323), Expect = 4e-30 Identities = 64/128 (50%), Positives = 88/128 (68%), Gaps = 1/128 (0%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSR-QYGSP 180 QP S VK + Q+L G+KYLH ++HRD+K N+L+N+ LKICDFGL+R + Sbjct: 222 QPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDE 281 Query: 181 LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKI 360 + TQ VVT +YRAPE+L+G++ YS AID+WS+GCI AELL ++ LF + I QL I Sbjct: 282 SRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLI 341 Query: 361 FRMLGTPN 384 +LGTP+ Sbjct: 342 TDLLGTPS 349
>NLK_HUMAN (Q9UBE8) Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like| kinase) (LAK1 protein) Length = 515 Score = 129 bits (323), Expect = 4e-30 Identities = 64/128 (50%), Positives = 88/128 (68%), Gaps = 1/128 (0%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSR-QYGSP 180 QP S VK + Q+L G+KYLH ++HRD+K N+L+N+ LKICDFGL+R + Sbjct: 222 QPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDE 281 Query: 181 LKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKI 360 + TQ VVT +YRAPE+L+G++ YS AID+WS+GCI AELL ++ LF + I QL I Sbjct: 282 SRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLI 341 Query: 361 FRMLGTPN 384 +LGTP+ Sbjct: 342 TDLLGTPS 349
>CDK9_RAT (Q641Z4) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 128 bits (322), Expect = 5e-30 Identities = 59/138 (42%), Positives = 88/138 (63%), Gaps = 4/138 (2%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYG----S 177 ++ SE+K +M LL G+ Y+H N ++HRD+K +N+L+ G LK+ DFGL+R + S Sbjct: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 Query: 178 PLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSK 357 YT VVTLWYR PELLLG ++Y ID+W GCIMAE+ ++ P+ G + QL+ Sbjct: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 Query: 358 IFRMLGTPNEDIWPGYSK 411 I ++ G+ ++WP K Sbjct: 241 ISQLCGSITPEVWPNVDK 258
>CDK9_MOUSE (Q99J95) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 128 bits (322), Expect = 5e-30 Identities = 59/138 (42%), Positives = 88/138 (63%), Gaps = 4/138 (2%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYG----S 177 ++ SE+K +M LL G+ Y+H N ++HRD+K +N+L+ G LK+ DFGL+R + S Sbjct: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 Query: 178 PLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSK 357 YT VVTLWYR PELLLG ++Y ID+W GCIMAE+ ++ P+ G + QL+ Sbjct: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 Query: 358 IFRMLGTPNEDIWPGYSK 411 I ++ G+ ++WP K Sbjct: 241 ISQLCGSITPEVWPNVDK 258
>CDK9_BOVIN (Q5EAB2) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 128 bits (322), Expect = 5e-30 Identities = 59/138 (42%), Positives = 88/138 (63%), Gaps = 4/138 (2%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYG----S 177 ++ SE+K +M LL G+ Y+H N ++HRD+K +N+L+ G LK+ DFGL+R + S Sbjct: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 Query: 178 PLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSK 357 YT VVTLWYR PELLLG ++Y ID+W GCIMAE+ ++ P+ G + QL+ Sbjct: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 Query: 358 IFRMLGTPNEDIWPGYSK 411 I ++ G+ ++WP K Sbjct: 241 ISQLCGSITPEVWPNVDK 258
>MPK1_ARATH (Q39021) Mitogen-activated protein kinase homolog 1 (EC 2.7.11.24)| (MAP kinase 1) (AtMPK1) Length = 370 Score = 128 bits (321), Expect = 6e-30 Identities = 62/129 (48%), Positives = 85/129 (65%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + QLL G+KY+H ++HRDLK N+L+N +LKICDFGL+R + Sbjct: 128 QVLSNDHCQYFLFQLLRGLKYIHSANILHRDLKPGNLLVNANCDLKICDFGLARASNTKG 187 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 + T+ VVT WYRAPELLL Y T+ID+WS+GCI AELL +KP+F G ++QL I Sbjct: 188 QFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAELLGRKPIFQGTECLNQLKLIV 247 Query: 364 RMLGTPNED 390 +LG+ E+ Sbjct: 248 NILGSQREE 256
>MK12_BRARE (O42376) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Stress-activated protein kinase 3) Length = 363 Score = 128 bits (321), Expect = 6e-30 Identities = 62/126 (49%), Positives = 88/126 (69%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S+ V+ L+ Q+L+G+KY+H +IHRDLK N+ +N ELKI DFGL+RQ S + Y Sbjct: 124 SEERVQYLVYQMLKGLKYIHAAGIIHRDLKPGNLAINEECELKILDFGLARQTDSEMTGY 183 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 VVT WYRAPE++L Y+ +D+WS+GCIMAE+L KPLF G +DQL +I ++ Sbjct: 184 ---VVTRWYRAPEVILSWMHYTQTVDIWSVGCIMAEMLLGKPLFKGHDHLDQLMEIMKVT 240 Query: 373 GTPNED 390 GTP+++ Sbjct: 241 GTPSKE 246
>CDK9B_XENLA (Q7ZX42) Cell division protein kinase 9-B (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9-B) Length = 376 Score = 127 bits (320), Expect = 8e-30 Identities = 58/138 (42%), Positives = 88/138 (63%), Gaps = 4/138 (2%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYG----S 177 ++ +E+K +M LL G+ Y+H N ++HRD+K +N+L+ G LK+ DFGL+R + S Sbjct: 125 FTVAEIKKVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 184 Query: 178 PLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSK 357 YT VVTLWYR PELLLG ++Y ID+W GCIMAE+ ++ P+ G + QL+ Sbjct: 185 QPNKYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLTL 244 Query: 358 IFRMLGTPNEDIWPGYSK 411 I ++ G+ ++WP K Sbjct: 245 ISQLCGSITPEVWPNVDK 262
>ERK1_CANAL (P28869) Extracellular signal-regulated kinase 1 (EC 2.7.11.24)| (ERK1) (MAP kinase 1) (MAPK 1) Length = 417 Score = 127 bits (320), Expect = 8e-30 Identities = 69/140 (49%), Positives = 93/140 (66%), Gaps = 4/140 (2%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S ++ + Q L +K +H V+HRDLK SN+LLN+ +LKICDFGL+R S Sbjct: 162 QNLSDDHIQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNSNCDLKICDFGLARSIASQE 221 Query: 184 KPY---TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLS 354 Y T+ V T WYRAPE++L +EY+TAID+WS+GCI+AE+LS +PLF G+ +QL Sbjct: 222 DNYGFMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCILAEMLSGRPLFPGRDYHNQLW 281 Query: 355 KIFRMLGTPN-EDIWPGYSK 411 I +LGTPN ED + SK Sbjct: 282 LIMEVLGTPNMEDYYNIKSK 301
>MPK5_ARATH (Q39025) Mitogen-activated protein kinase homolog 5 (EC 2.7.11.24)| (MAP kinase 5) (AtMPK5) Length = 376 Score = 127 bits (319), Expect = 1e-29 Identities = 62/127 (48%), Positives = 90/127 (70%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + + + Q+L G+KY+H V+HRDLK SN+LLN+ +LKI DFGL+R S Sbjct: 139 QSLNDDHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNSNCDLKITDFGLARTT-SET 197 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 + T+ VVT WYRAPELLL + EY++AID+WS+GCI AE+++++PLF GK + QL I Sbjct: 198 EYMTEYVVTRWYRAPELLLNSSEYTSAIDVWSVGCIFAEIMTREPLFPGKDYVHQLKLIT 257 Query: 364 RMLGTPN 384 ++G+P+ Sbjct: 258 ELIGSPD 264
>CDK9_CHICK (Q5ZKN1) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 127 bits (319), Expect = 1e-29 Identities = 59/138 (42%), Positives = 88/138 (63%), Gaps = 4/138 (2%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYG----S 177 ++ SE+K +M LL G+ Y+H N ++HRD+K +N+L+ G LK+ DFGL+R + S Sbjct: 121 FTLSEIKKVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 Query: 178 PLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSK 357 YT VVTLWYR PELLLG ++Y ID+W GCIMAE+ ++ P+ G + QL+ Sbjct: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGGGCIMAEMWTRSPIMQGNTEQHQLTL 240 Query: 358 IFRMLGTPNEDIWPGYSK 411 I ++ G+ ++WP K Sbjct: 241 ISQLCGSITPEVWPNVDK 258
>MPK2_ARATH (Q39022) Mitogen-activated protein kinase homolog 2 (EC 2.7.11.24)| (MAP kinase 2) (AtMPK2) Length = 376 Score = 127 bits (318), Expect = 1e-29 Identities = 61/129 (47%), Positives = 85/129 (65%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + QLL G+KY+H ++HRDLK N+L+N +LKICDFGL+R + Sbjct: 128 QVLSNDHCQYFLFQLLRGLKYIHSANILHRDLKPGNLLVNANCDLKICDFGLARTSNTKG 187 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 + T+ VVT WYRAPELLL Y T+ID+WS+GCI AELL +KP+F G ++Q+ I Sbjct: 188 QFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAELLGRKPVFPGTECLNQIKLII 247 Query: 364 RMLGTPNED 390 +LG+ E+ Sbjct: 248 NILGSQREE 256
>CDK9_HUMAN (P50750) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4) Length = 372 Score = 127 bits (318), Expect = 1e-29 Identities = 58/134 (43%), Positives = 87/134 (64%), Gaps = 4/134 (2%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYG----S 177 ++ SE+K +M LL G+ Y+H N ++HRD+K +N+L+ G LK+ DFGL+R + S Sbjct: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 Query: 178 PLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSK 357 YT VVTLWYR PELLLG ++Y ID+W GCIMAE+ ++ P+ G + QL+ Sbjct: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 Query: 358 IFRMLGTPNEDIWP 399 I ++ G+ ++WP Sbjct: 241 ISQLCGSITPEVWP 254
>PMK1_CAEEL (Q17446) Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (p38| MAP kinase 1) (Stress-activated protein kinase pmk-1) Length = 377 Score = 127 bits (318), Expect = 1e-29 Identities = 62/129 (48%), Positives = 87/129 (67%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + ++ L+ Q+L G+KY+H +IHRDLK SNI +N ELKI DFGL+RQ S + Sbjct: 131 QRLNDDHIQFLVYQILRGLKYIHSADIIHRDLKPSNIAVNEDCELKILDFGLARQTDSEM 190 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ +D+WS+GCI+AEL++ K LF G IDQL++I Sbjct: 191 TGY---VATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELITGKTLFPGSDHIDQLTRIM 247 Query: 364 RMLGTPNED 390 + GTP+E+ Sbjct: 248 SVTGTPDEE 256
>MPK7_ARATH (Q39027) Mitogen-activated protein kinase homolog 7 (EC 2.7.11.24)| (MAP kinase 7) (AtMPK7) Length = 368 Score = 127 bits (318), Expect = 1e-29 Identities = 62/128 (48%), Positives = 83/128 (64%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S K + QLL G+KYLH ++HRDLK N+L+N +LKICDFGL+R Sbjct: 128 QSLSDDHCKYFLFQLLRGLKYLHSANILHRDLKPGNLLVNANCDLKICDFGLARTSQGNE 187 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 + T+ VVT WYRAPELLL Y T+ID+WS+GCI AE+L +KP+F G ++QL I Sbjct: 188 QFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAEILGRKPIFPGTECLNQLKLII 247 Query: 364 RMLGTPNE 387 ++G+ E Sbjct: 248 NVVGSQQE 255
>NTF6_TOBAC (Q40531) Mitogen-activated protein kinase homolog NTF6 (EC| 2.7.11.24) (P43) Length = 371 Score = 126 bits (317), Expect = 2e-29 Identities = 64/128 (50%), Positives = 85/128 (66%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + + + QLL G+KY+H V+HRDLK SN+LLN +LKICDFGL+R S Sbjct: 134 QALTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDFGLARTT-SEA 192 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 T+ VVT WYRAPELLL EY+ AID+WS+GCI+ EL+ ++PLF G+ QL I Sbjct: 193 DFMTEYVVTRWYRAPELLLNCTEYTAAIDIWSVGCILMELIKREPLFPGRDYAQQLGLII 252 Query: 364 RMLGTPNE 387 +LG+P + Sbjct: 253 ALLGSPED 260
>MAPK_PETHY (Q40884) Mitogen-activated protein kinase homolog 1 (EC 2.7.11.24)| (PMEK1) Length = 384 Score = 126 bits (317), Expect = 2e-29 Identities = 61/129 (47%), Positives = 84/129 (65%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + QLL G+KYLH ++HRDLK N+L+N +LKICDFGL+R Sbjct: 128 QTLSNDHCQYFLFQLLRGLKYLHSANILHRDLKPGNLLINANCDLKICDFGLARTSSGKD 187 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 + T+ VVT WYRAPELLL Y T+ID+WS+GCI A++L +KP+F G ++QL I Sbjct: 188 QFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFADVLGRKPVFPGTECLNQLKLII 247 Query: 364 RMLGTPNED 390 +LG+ E+ Sbjct: 248 NILGSQREE 256
>SLT2_YEAST (Q00772) Mitogen-activated protein kinase SLT2/MPK1 (EC 2.7.11.24)| (MAP kinase MPK1) Length = 484 Score = 126 bits (317), Expect = 2e-29 Identities = 62/133 (46%), Positives = 92/133 (69%), Gaps = 4/133 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYG-SP 180 QP + + + Q+L G+KY+H V+HRDLK N+L+N +LKICDFGL+R Y +P Sbjct: 123 QPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGYSENP 182 Query: 181 LKP---YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 ++ T+ V T WYRAPE++L + Y+ AID+WS GCI+AE L KP+F GK ++QL Sbjct: 183 VENSQFLTEYVATRWYRAPEIMLSYQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQL 242 Query: 352 SKIFRMLGTPNED 390 ++I ++LGTP ++ Sbjct: 243 NQILQVLGTPPDE 255
>MKC1_CANAL (P43068) Mitogen-activated protein kinase MKC1 (EC 2.7.11.24) (MAP| kinase MKC1) Length = 501 Score = 126 bits (317), Expect = 2e-29 Identities = 64/132 (48%), Positives = 86/132 (65%), Gaps = 4/132 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 QP S + + Q+L G+ ++H V+HRDLK N+L+N ELKICDFGL+R + Sbjct: 144 QPLSDQHYQSFIYQVLCGLNFIHSADVLHRDLKPGNLLVNADCELKICDFGLARGFSENP 203 Query: 184 KP----YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 T+ V T WYRAPE++L Y+ AID+WS+GCI+AELL KPLF GK +DQL Sbjct: 204 DENAGFMTEYVATRWYRAPEIMLSFTNYTKAIDIWSVGCILAELLGGKPLFRGKDYVDQL 263 Query: 352 SKIFRMLGTPNE 387 ++I +LGTP E Sbjct: 264 NQILMILGTPPE 275
>CDK9_CAEEL (Q9TVL3) Probable cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 478 Score = 126 bits (316), Expect = 2e-29 Identities = 58/137 (42%), Positives = 87/137 (63%), Gaps = 6/137 (4%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY------GSPLK 186 +K +M L+ G+ LH + ++HRD+K +N+L++ G LK+ DFGL+R + P Sbjct: 194 IKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRP 253 Query: 187 PYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFR 366 YT VVTLWYR PELLLG ++Y T ID+W GCIMAE+ +++P+ G + QL I Sbjct: 254 LYTNRVVTLWYRPPELLLGDRQYGTKIDVWGAGCIMAEMWTRQPIMQGDTEQKQLQLISG 313 Query: 367 MLGTPNEDIWPGYSKLP 417 + G+ N+D+WP +P Sbjct: 314 LCGSINKDVWPNCVNMP 330
>ICK_HUMAN (Q9UPZ9) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2) Length = 632 Score = 125 bits (315), Expect = 3e-29 Identities = 61/133 (45%), Positives = 90/133 (67%), Gaps = 1/133 (0%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 + +S ++ +M Q+L+G+ ++H + HRDLK N+L +KI DFGL+R+ S P Sbjct: 97 FPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSK-PP 155 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 YT V T WYRAPE+LL + YS+ ID+W++GCIMAE+ + +PLF G +ID + KI ++ Sbjct: 156 YTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQV 215 Query: 370 LGTPNEDIWP-GY 405 LGTP + WP GY Sbjct: 216 LGTPKKTDWPEGY 228
>ICK_RAT (Q62726) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (MAK-related kinase) (MRK) Length = 629 Score = 125 bits (314), Expect = 4e-29 Identities = 61/133 (45%), Positives = 90/133 (67%), Gaps = 1/133 (0%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 + +S ++ +M Q+L+G+ ++H + HRDLK N+L +KI DFGL+R+ S P Sbjct: 97 FPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSR-PP 155 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 YT V T WYRAPE+LL + YS+ ID+W++GCIMAE+ + +PLF G +ID + KI ++ Sbjct: 156 YTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQV 215 Query: 370 LGTPNEDIWP-GY 405 LGTP + WP GY Sbjct: 216 LGTPKKTDWPEGY 228
>ICK_MOUSE (Q9JKV2) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK) Length = 629 Score = 125 bits (314), Expect = 4e-29 Identities = 61/133 (45%), Positives = 90/133 (67%), Gaps = 1/133 (0%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 + +S ++ +M Q+L+G+ ++H + HRDLK N+L +KI DFGL+R+ S P Sbjct: 97 FPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSR-PP 155 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 YT V T WYRAPE+LL + YS+ ID+W++GCIMAE+ + +PLF G +ID + KI ++ Sbjct: 156 YTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEVYTLRPLFPGASEIDTIFKICQV 215 Query: 370 LGTPNEDIWP-GY 405 LGTP + WP GY Sbjct: 216 LGTPKKTDWPEGY 228
>MK07_HUMAN (Q13164) Mitogen-activated protein kinase 7 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase) Length = 815 Score = 125 bits (314), Expect = 4e-29 Identities = 65/131 (49%), Positives = 87/131 (66%), Gaps = 4/131 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY-GSP 180 QP + V+ + QLL G+KY+H VIHRDLK SN+L+N ELKI DFG++R SP Sbjct: 151 QPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSP 210 Query: 181 LKPY---TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 + T+ V T WYRAPEL+L EY+ AID+WS+GCI E+L+++ LF GK + QL Sbjct: 211 AEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQL 270 Query: 352 SKIFRMLGTPN 384 I +LGTP+ Sbjct: 271 QLIMMVLGTPS 281
>MK07_MOUSE (Q9WVS8) Mitogen-activated protein kinase 7 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase) Length = 806 Score = 125 bits (314), Expect = 4e-29 Identities = 65/131 (49%), Positives = 87/131 (66%), Gaps = 4/131 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY-GSP 180 QP + V+ + QLL G+KY+H VIHRDLK SN+L+N ELKI DFG++R SP Sbjct: 152 QPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSP 211 Query: 181 LKPY---TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 + T+ V T WYRAPEL+L EY+ AID+WS+GCI E+L+++ LF GK + QL Sbjct: 212 AEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQL 271 Query: 352 SKIFRMLGTPN 384 I +LGTP+ Sbjct: 272 QLIMMVLGTPS 282
>MPK4_ARATH (Q39024) Mitogen-activated protein kinase homolog 4 (EC 2.7.11.24)| (MAP kinase 4) (AtMPK4) Length = 376 Score = 125 bits (313), Expect = 5e-29 Identities = 62/128 (48%), Positives = 87/128 (67%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 QP + + + QLL G+KY+H V+HRDLK SN+LLN +LK+ DFGL+R S Sbjct: 139 QPLTDDHCRFFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKLGDFGLARTK-SET 197 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 T+ VVT WYRAPELLL EY+ AID+WS+GCI+ E ++++PLF GK + QL I Sbjct: 198 DFMTEYVVTRWYRAPELLLNCSEYTAAIDIWSVGCILGETMTREPLFPGKDYVHQLRLIT 257 Query: 364 RMLGTPNE 387 ++G+P++ Sbjct: 258 ELIGSPDD 265
>MK11_HUMAN (Q15759) Mitogen-activated protein kinase 11 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress-activated protein kinase 2) Length = 372 Score = 125 bits (313), Expect = 5e-29 Identities = 61/123 (49%), Positives = 83/123 (67%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 V+ L+ QLL G+KY+H +IHRDLK SN+ +N EL+I DFGL+RQ + Y V Sbjct: 135 VQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGY---V 191 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPN 384 T WYRAPE++L Y+ +D+WS+GCIMAELL K LF G IDQL +I ++GTP+ Sbjct: 192 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS 251 Query: 385 EDI 393 ++ Sbjct: 252 PEV 254
>MK14_CANFA (O02812) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) Length = 359 Score = 125 bits (313), Expect = 5e-29 Identities = 62/130 (47%), Positives = 84/130 (64%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + V+ L+ Q+L G+KY+H +IHRDLK SN+ +N ELKI DFGL+R + Sbjct: 119 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 178 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ +D+WS+GCIMAELL+ + LF G IDQL I Sbjct: 179 TGY---VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 235 Query: 364 RMLGTPNEDI 393 R++GTP D+ Sbjct: 236 RLVGTPGADL 245
>MK11_MOUSE (Q9WUI1) Mitogen-activated protein kinase 11 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B) Length = 364 Score = 125 bits (313), Expect = 5e-29 Identities = 62/130 (47%), Positives = 84/130 (64%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S V+ L+ QLL G+KY+H +IHRDLK SN+ +N EL+I DFGL+ Q + Sbjct: 120 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAPQADEEM 179 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ +D+WS+GCIMAELL K LF G IDQL +I Sbjct: 180 TGY---VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIM 236 Query: 364 RMLGTPNEDI 393 ++GTP+ ++ Sbjct: 237 EVVGTPSPEV 246
>ERK1_DICDI (P42525) Extracellular signal-regulated kinase 1 (EC 2.7.11.24)| (ERK1) (MAP kinase 1) Length = 415 Score = 125 bits (313), Expect = 5e-29 Identities = 61/130 (46%), Positives = 88/130 (67%), Gaps = 1/130 (0%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 QP S + + Q+L G+K++H V+HRDLK SN+L+N LKICD GL+R + Sbjct: 127 QPLSDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVEDATH 186 Query: 184 KPY-TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKI 360 + + T+ V T WYRAPE++L +Y+ AID+WS+GCI AELL +KPLF GK I Q++ I Sbjct: 187 QGFMTEYVATRWYRAPEVILSWNKYTKAIDIWSVGCIFAELLGRKPLFQGKDYIHQITLI 246 Query: 361 FRMLGTPNED 390 +G+P+E+ Sbjct: 247 IETIGSPSEE 256
>MK14_XENLA (P47812) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated Mitogen-activated protein kinase 2) (MAP kinase 2) (MPK2) Length = 361 Score = 124 bits (311), Expect = 9e-29 Identities = 61/130 (46%), Positives = 84/130 (64%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + V+ L+ Q+L G+KY+H +IHRDLK SN+ +N ELKI DFGL+R + Sbjct: 121 QKLTDDHVQFLIYQILRGLKYIHSAGIIHRDLKPSNLAVNEDCELKILDFGLARHTDEEM 180 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ +D+WS+GCIMAELL+ + LF G IDQL I Sbjct: 181 TGY---VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 237 Query: 364 RMLGTPNEDI 393 R++GTP ++ Sbjct: 238 RLVGTPEPEL 247
>MK13_PANTR (Q9N272) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) Length = 365 Score = 124 bits (311), Expect = 9e-29 Identities = 58/127 (45%), Positives = 88/127 (69%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 +S+ +++ L+ Q+L+G+KY+H V+HRDLK N+ +N ELKI DFGL+R + + Sbjct: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG 181 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 Y VVT WYRAPE++L Y+ +D+WS+GCIMAE+L+ K LF GK +DQL++I ++ Sbjct: 182 Y---VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 Query: 370 LGTPNED 390 G P + Sbjct: 239 TGVPGTE 245
>MK13_HUMAN (O15264) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 365 Score = 124 bits (311), Expect = 9e-29 Identities = 58/127 (45%), Positives = 88/127 (69%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 +S+ +++ L+ Q+L+G+KY+H V+HRDLK N+ +N ELKI DFGL+R + + Sbjct: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTG 181 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 Y VVT WYRAPE++L Y+ +D+WS+GCIMAE+L+ K LF GK +DQL++I ++ Sbjct: 182 Y---VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 Query: 370 LGTPNED 390 G P + Sbjct: 239 TGVPGTE 245
>SPM1_SCHPO (Q92398) Mitogen-activated protein kinase spm1 (EC 2.7.11.24) (MAP| kinase spm1) (MAP kinase pmk1) Length = 422 Score = 124 bits (311), Expect = 9e-29 Identities = 65/135 (48%), Positives = 85/135 (62%), Gaps = 6/135 (4%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 QP + + + + Q+L G+KY+H VIHRDLK N+L+N ELKICDFGL+R G Sbjct: 119 QPLTDAHFQSFIYQILCGLKYIHSANVIHRDLKPGNLLVNADCELKICDFGLAR--GCSE 176 Query: 184 KP------YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDID 345 P T+ V T WYRAPE++L Y ID+WS+GCI+AELL PLF GK + Sbjct: 177 NPEENPGFMTEYVATRWYRAPEIMLSFSSYHKGIDVWSVGCILAELLGGTPLFKGKDFVH 236 Query: 346 QLSKIFRMLGTPNED 390 QL+ I LGTP+E+ Sbjct: 237 QLNLILHQLGTPDEE 251
>SMK1_YEAST (P41808) Sporulation-specific mitogen-activated protein kinase SMK1| (EC 2.7.11.24) (MAP kinase SMK1) Length = 388 Score = 124 bits (311), Expect = 9e-29 Identities = 63/135 (46%), Positives = 92/135 (68%), Gaps = 8/135 (5%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSR-------QY 171 S+ +K + Q+L G+KY+H VIHRDLK NIL G LKICDFGL+R + Sbjct: 139 SEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKC 198 Query: 172 GSPLKPY-TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQ 348 S ++P+ T V T WYRAPELLL + YS ++D+W++GCI+AE ++KP+F G+ + Q Sbjct: 199 HSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDIWAVGCILAEFYARKPVFMGRDSMHQ 258 Query: 349 LSKIFRMLGTPNEDI 393 + +I ++LGTP++DI Sbjct: 259 IFEIIKVLGTPDKDI 273
>MK13_RAT (Q9WTY9) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 366 Score = 124 bits (311), Expect = 9e-29 Identities = 58/127 (45%), Positives = 88/127 (69%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 +S+ +V+ L+ Q+L+G+KY+H ++HRDLK N+ +N ELKI DFGL+R + + Sbjct: 122 FSEEKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDAEMTG 181 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 Y VVT WYRAPE++L Y+ +D+WS+GCIMAE+L+ K LF GK +DQL++I ++ Sbjct: 182 Y---VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 Query: 370 LGTPNED 390 G P + Sbjct: 239 TGVPGAE 245
>MK13_MOUSE (Q9Z1B7) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 366 Score = 124 bits (311), Expect = 9e-29 Identities = 58/127 (45%), Positives = 88/127 (69%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 +S+ +V+ L+ Q+L+G+KY+H ++HRDLK N+ +N ELKI DFGL+R + + Sbjct: 122 FSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTEMTG 181 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 Y VVT WYRAPE++L Y+ +D+WS+GCIMAE+L+ K LF GK +DQL++I ++ Sbjct: 182 Y---VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 238 Query: 370 LGTPNED 390 G P + Sbjct: 239 TGVPGAE 245
>MK12_RAT (Q63538) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 124 bits (310), Expect = 1e-28 Identities = 60/123 (48%), Positives = 85/123 (69%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S+ ++ L+ Q+L+G+KY+H VIHRDLK N+ +N ELKI DFGL+RQ S + Y Sbjct: 126 SEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY 185 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 VVT WYRAPE++L Y+ +D+WS+GCIMAE+++ K LF G +DQL +I ++ Sbjct: 186 ---VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKVT 242 Query: 373 GTP 381 GTP Sbjct: 243 GTP 245
>MK12_MOUSE (O08911) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 124 bits (310), Expect = 1e-28 Identities = 60/123 (48%), Positives = 85/123 (69%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S+ ++ L+ Q+L+G+KY+H VIHRDLK N+ +N ELKI DFGL+RQ S + Y Sbjct: 126 SEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY 185 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 VVT WYRAPE++L Y+ +D+WS+GCIMAE+++ K LF G +DQL +I ++ Sbjct: 186 ---VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKIT 242 Query: 373 GTP 381 GTP Sbjct: 243 GTP 245
>SPK1_SCHPO (P27638) Mitogen-activated protein kinase spk1 (EC 2.7.11.24) (MAP| kinase spk1) (MAPK) Length = 372 Score = 124 bits (310), Expect = 1e-28 Identities = 65/133 (48%), Positives = 86/133 (64%), Gaps = 4/133 (3%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSR----QY 171 QP S + Q+L +K +H V+HRDLK SN+LLN +LK+ DFGL+R Q Sbjct: 133 QPLSDDHCQYFTYQILRALKAMHSAGVVHRDLKPSNLLLNANCDLKVADFGLARSTTAQG 192 Query: 172 GSPLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 G+P T+ V T WYRAPE++L +EYS AID+WS GCI+AE+LS +PLF GK Q+ Sbjct: 193 GNP-GFMTEYVATRWYRAPEIMLSFREYSKAIDLWSTGCILAEMLSARPLFPGKDYHSQI 251 Query: 352 SKIFRMLGTPNED 390 + I +LGTP D Sbjct: 252 TLILNILGTPTMD 264
>MMK2_MEDSA (Q40353) Mitogen-activated protein kinase homolog MMK2 (EC| 2.7.11.24) Length = 371 Score = 123 bits (309), Expect = 2e-28 Identities = 60/128 (46%), Positives = 88/128 (68%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 QP + + + QLL G+KY+H V+HRDLK SN+LLN +LKI DFGL+R S Sbjct: 133 QPMTDDHCRYFVYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKIGDFGLARTT-SET 191 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 T+ VVT WYRAPELLL +Y+ AID+WS+GCI+ E+++++PLF G+ + QL + Sbjct: 192 DFMTEYVVTRWYRAPELLLNCSDYTAAIDIWSVGCILGEIVTRQPLFPGRDYVHQLRLVT 251 Query: 364 RMLGTPNE 387 ++G+P++ Sbjct: 252 ELIGSPDD 259
>MK14_RAT (P70618) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1) Length = 359 Score = 123 bits (309), Expect = 2e-28 Identities = 61/130 (46%), Positives = 84/130 (64%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + V+ L+ Q+L G+KY+H +IHRDLK SN+ +N ELKI DFGL+R + Sbjct: 119 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 178 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ +D+WS+GCIMAELL+ + LF G IDQL I Sbjct: 179 TGY---VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 235 Query: 364 RMLGTPNEDI 393 R++GTP ++ Sbjct: 236 RLVGTPGAEL 245
>MK14_MOUSE (P47811) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1) Length = 359 Score = 123 bits (309), Expect = 2e-28 Identities = 61/130 (46%), Positives = 84/130 (64%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + V+ L+ Q+L G+KY+H +IHRDLK SN+ +N ELKI DFGL+R + Sbjct: 119 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 178 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ +D+WS+GCIMAELL+ + LF G IDQL I Sbjct: 179 TGY---VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 235 Query: 364 RMLGTPNEDI 393 R++GTP ++ Sbjct: 236 RLVGTPGAEL 245
>MK14_HUMAN (Q16539) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting prote Length = 359 Score = 123 bits (309), Expect = 2e-28 Identities = 61/130 (46%), Positives = 84/130 (64%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + V+ L+ Q+L G+KY+H +IHRDLK SN+ +N ELKI DFGL+R + Sbjct: 119 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 178 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ +D+WS+GCIMAELL+ + LF G IDQL I Sbjct: 179 TGY---VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 235 Query: 364 RMLGTPNEDI 393 R++GTP ++ Sbjct: 236 RLVGTPGAEL 245
>CPK1_CRYNE (Q8NK05) Mitogen-activated protein kinase CPK1 (EC 2.7.11.24)| (Stress-activated protein kinase CPK1) Length = 366 Score = 123 bits (309), Expect = 2e-28 Identities = 65/137 (47%), Positives = 86/137 (62%), Gaps = 8/137 (5%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + Q L G+K LH V+HRDLK SN+LLN +LKICDFGL+R P Sbjct: 110 QELSDDHCQYFVYQTLRGLKALHSADVLHRDLKPSNLLLNANCDLKICDFGLARSSAKPP 169 Query: 184 KP--------YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRD 339 T+ V T WYRAPE++L +EY+ AID+WS+GCI+AE+++ KPLF G+ Sbjct: 170 PGTSDGGQGFMTEYVATRWYRAPEVMLSFQEYTKAIDLWSVGCILAEMINGKPLFPGRDY 229 Query: 340 IDQLSKIFRMLGTPNED 390 QLS I ++LGTP D Sbjct: 230 HHQLSLILQVLGTPTMD 246
>CDKL2_RABIT (Q9TTK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 566 Score = 123 bits (308), Expect = 2e-28 Identities = 54/117 (46%), Positives = 80/117 (68%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 V+ + Q++ G+ + H + +IHRD+K NIL++ G +K+CDFG +R +P + YT V Sbjct: 103 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 T WYRAPELL+G +Y A+D+W++GC++ E+L +PLF G DIDQL I R LG Sbjct: 163 ATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMLMGEPLFPGDSDIDQLYLIMRCLG 219
>HOG1_CANAL (Q92207) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 377 Score = 122 bits (307), Expect = 3e-28 Identities = 59/130 (45%), Positives = 86/130 (66%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 +P + ++ Q++ G+KY+H VIHRDLK SNIL+N +LKICDFGL+R + Sbjct: 114 RPLEKQFIQYFTYQIMRGLKYIHSAGVIHRDLKPSNILINENCDLKICDFGLARLQDPQM 173 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T +YRAPE++L ++Y T +D+WS+GCI+AE++ KPLF GK + Q S I Sbjct: 174 TGY---VSTRYYRAPEIMLTWQKYDTEVDLWSVGCILAEMIEGKPLFPGKDHVHQFSIIT 230 Query: 364 RMLGTPNEDI 393 +LG+P D+ Sbjct: 231 ELLGSPPADV 240
>MAK_RAT (P20793) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 622 Score = 122 bits (306), Expect = 3e-28 Identities = 59/133 (44%), Positives = 90/133 (67%), Gaps = 1/133 (0%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 + +S ++ +M Q+L+G+ ++H + HRD+K N+L +KI DFGL+R+ S P Sbjct: 97 FPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PP 155 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 YT V T WYRAPE+LL + YS+ ID+W++G IMAEL + +PLF G ++D++ KI ++ Sbjct: 156 YTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFRPLFPGTSEVDEIFKICQV 215 Query: 370 LGTPNEDIWP-GY 405 LGTP + WP GY Sbjct: 216 LGTPKKSDWPEGY 228
>MAK_MOUSE (Q04859) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) (Protein kinase RCK) Length = 622 Score = 122 bits (306), Expect = 3e-28 Identities = 59/133 (44%), Positives = 90/133 (67%), Gaps = 1/133 (0%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 + +S ++ +M Q+L+G+ ++H + HRD+K N+L +KI DFGL+R+ S P Sbjct: 97 FPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PP 155 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 YT V T WYRAPE+LL + YS+ ID+W++G IMAEL + +PLF G ++D++ KI ++ Sbjct: 156 YTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFRPLFPGTSEVDEIFKICQV 215 Query: 370 LGTPNEDIWP-GY 405 LGTP + WP GY Sbjct: 216 LGTPKKSDWPEGY 228
>CDKL2_RAT (Q5XIT0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 507 Score = 122 bits (305), Expect = 4e-28 Identities = 53/117 (45%), Positives = 80/117 (68%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 V+ + Q++ G+ + H + +IHRD+K NIL++ G +K+CDFG +R +P + YT V Sbjct: 103 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 T WYRAPELL+G +Y A+D+W++GC++ E+L +PLF G+ DIDQL I LG Sbjct: 163 ATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLG 219
>MAK_HUMAN (P20794) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 623 Score = 122 bits (305), Expect = 4e-28 Identities = 59/133 (44%), Positives = 89/133 (66%), Gaps = 1/133 (0%) Frame = +1 Query: 10 YSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP 189 + +S ++ +M Q+L+G+ ++H + HRD+K N+L +KI DFGL+R+ S P Sbjct: 97 FPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PP 155 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 YT V T WYRAPE+LL + YS+ ID+W++G IMAEL +PLF G ++D++ KI ++ Sbjct: 156 YTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQV 215 Query: 370 LGTPNEDIWP-GY 405 LGTP + WP GY Sbjct: 216 LGTPKKSDWPEGY 228
>MK14A_DROME (O62618) Mitogen-activated protein kinase 14A (EC 2.7.11.24) (MAP| kinase p38a) (p38 MAPK) (Dp38) (D-p38a) Length = 366 Score = 122 bits (305), Expect = 4e-28 Identities = 62/126 (49%), Positives = 82/126 (65%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S V+ L+ Q+L G+KY+H VIHRDLK SNI +N EL+I DFGL+R + + Sbjct: 124 QHLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEM 183 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y +D+WS+GCIMAEL++++ LF G I QL+ I Sbjct: 184 TGY---VATRWYRAPEIMLNWMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIM 240 Query: 364 RMLGTP 381 MLGTP Sbjct: 241 EMLGTP 246
>CDKL2_MOUSE (Q9QUK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 568 Score = 122 bits (305), Expect = 4e-28 Identities = 53/117 (45%), Positives = 80/117 (68%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 V+ + Q++ G+ + H + +IHRD+K NIL++ G +K+CDFG +R +P + YT V Sbjct: 103 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 T WYRAPELL+G +Y A+D+W++GC++ E+L +PLF G+ DIDQL I LG Sbjct: 163 ATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLG 219
>MK12_HUMAN (P53778) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 121 bits (304), Expect = 6e-28 Identities = 57/122 (46%), Positives = 84/122 (68%) Frame = +1 Query: 16 QSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYT 195 + ++ L+ Q+L+G++Y+H +IHRDLK N+ +N ELKI DFGL+RQ S + Y Sbjct: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY- 185 Query: 196 QLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 VVT WYRAPE++L Y+ +D+WS+GCIMAE+++ K LF G +DQL +I ++ G Sbjct: 186 --VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 Query: 376 TP 381 TP Sbjct: 244 TP 245
>PMK2_CAEEL (Q8MXI4) Mitogen-activated protein kinase pmk-2 (EC 2.7.11.24) (p38| MAP kinase 2) (Stress-activated protein kinase pmk-2) Length = 419 Score = 121 bits (304), Expect = 6e-28 Identities = 62/148 (41%), Positives = 89/148 (60%), Gaps = 17/148 (11%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELK-------------- 141 Q + +++ L+ Q+L G+KY+H +IHRDLK SNI +N E+K Sbjct: 145 QRLTDEQIQLLIYQVLRGLKYIHSAGIIHRDLKPSNIAVNERCEVKVFLSFSQLSFLILS 204 Query: 142 ---ICDFGLSRQYGSPLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSK 312 I DFGL+R + + Y V T WYRAPE++L Y+ +D+WS+GCI+AEL+S Sbjct: 205 FFKILDFGLARAQDAEMTGY---VATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELVSG 261 Query: 313 KPLFDGKRDIDQLSKIFRMLGTPNEDIW 396 +PLF G IDQL+KI ++GTP E+ W Sbjct: 262 RPLFPGDDHIDQLTKIMSVVGTPKEEFW 289
>HOG1_DEBHA (Q9UV50) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 387 Score = 121 bits (304), Expect = 6e-28 Identities = 59/130 (45%), Positives = 86/130 (66%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 +P + ++ Q+L G+KY+H VIHRDLK SNIL+N +LKICDFGL+R + Sbjct: 114 RPLEKQFIQYFTYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQM 173 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T +YRAPE++L ++Y T +D+WS+GCI++E++ KPLF GK + Q S I Sbjct: 174 TGY---VSTRYYRAPEIMLTWQKYDTEVDLWSVGCILSEMIEGKPLFPGKDHVHQFSIIT 230 Query: 364 RMLGTPNEDI 393 +LG+P D+ Sbjct: 231 ELLGSPPPDV 240
>MK14A_BRARE (Q9DGE2) Mitogen-activated protein kinase 14a (EC 2.7.11.24)| (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (zp38a) Length = 361 Score = 121 bits (303), Expect = 8e-28 Identities = 60/126 (47%), Positives = 82/126 (65%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + V+ L+ Q+L G+KY+H +IHRDLK SN+ +N ELKI DFGL+R + Sbjct: 121 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 180 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ +D+WS+GCIMAELL+ + LF G I+QL +I Sbjct: 181 TGY---VATRWYRAPEIMLNWMHYNVTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIM 237 Query: 364 RMLGTP 381 R+ GTP Sbjct: 238 RLTGTP 243
>MAPK_FUSSO (Q00859) Mitogen-activated protein kinase (EC 2.7.11.24) (FsMAPK)| Length = 355 Score = 121 bits (303), Expect = 8e-28 Identities = 65/136 (47%), Positives = 86/136 (63%), Gaps = 3/136 (2%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S + + Q L +K +H V+HRDLK SN+LLN +LK+CDFGL+R S Sbjct: 117 QDLSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASQE 176 Query: 184 KP---YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLS 354 T+ V T WYRAPE++L KEY+ AID+WS+GCI+AE+LS KPLF GK QL+ Sbjct: 177 DNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLT 236 Query: 355 KIFRMLGTPNEDIWPG 402 I +LGTP + + G Sbjct: 237 LILDVLGTPTMEDYYG 252
>MK14A_CYPCA (Q90336) Mitogen-activated protein kinase 14a (EC 2.7.11.24)| (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (cp38a) Length = 361 Score = 120 bits (302), Expect = 1e-27 Identities = 60/126 (47%), Positives = 82/126 (65%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + V+ L+ Q+L G+KY+H +IHRDLK SN+ +N ELKI DFGL+R + Sbjct: 121 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 180 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ +D+WS+GCIMAELL+ + LF G I+QL +I Sbjct: 181 TGY---VATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIM 237 Query: 364 RMLGTP 381 R+ GTP Sbjct: 238 RLTGTP 243
>MK14_PANTR (Q95NE7) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) Length = 359 Score = 120 bits (302), Expect = 1e-27 Identities = 60/126 (47%), Positives = 82/126 (65%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + V+ L+ Q+L G+KY+H +IHRDLK SN+ +N ELKI DFGL+R + Sbjct: 119 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM 178 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ +D+WS+GCIMAELL+ + LF G I+QL +I Sbjct: 179 TGY---VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIM 235 Query: 364 RMLGTP 381 R+ GTP Sbjct: 236 RLTGTP 241
>MK14B_DROME (O61443) Mitogen-activated protein kinase 14B (EC 2.7.11.24) (MAP| kinase p38b) (D-p38b) Length = 365 Score = 120 bits (302), Expect = 1e-27 Identities = 63/129 (48%), Positives = 83/129 (64%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q S V+ L+ Q+L G+KY+H VIHRDLK SNI +N EL+I DFGL+R S + Sbjct: 123 QKLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESEM 182 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ D+WS+GCIMAELL+ + LF G I QL+ I Sbjct: 183 TGY---VATRWYRAPEIMLNWMHYNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIM 239 Query: 364 RMLGTPNED 390 +LGTP ++ Sbjct: 240 EVLGTPADE 248
>HOG1_YEAST (P32485) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) (Osmosensing protein HOG1) Length = 435 Score = 120 bits (301), Expect = 1e-27 Identities = 60/130 (46%), Positives = 85/130 (65%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 +P + V+ + Q+L G+KY+H VIHRDLK SNIL+N +LKICDFGL+R + Sbjct: 114 RPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQM 173 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T +YRAPE++L ++Y +D+WS GCI AE++ KPLF GK + Q S I Sbjct: 174 TGY---VSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIIT 230 Query: 364 RMLGTPNEDI 393 +LG+P +D+ Sbjct: 231 DLLGSPPKDV 240
>MK14B_CYPCA (Q9I958) Mitogen-activated protein kinase 14b (EC 2.7.11.24)| (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (cp38b) Length = 361 Score = 120 bits (300), Expect = 2e-27 Identities = 60/126 (47%), Positives = 82/126 (65%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + V+ L+ Q+L G+KY+H +IHRDLK SN+ +N ELKI DFGL+R + Sbjct: 121 QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARLTDDEM 180 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ +D+WS+GCIMAELL+ + LF G I+QL +I Sbjct: 181 TGY---VATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIM 237 Query: 364 RMLGTP 381 R+ GTP Sbjct: 238 RLTGTP 243
>CDKL2_MACFA (Q4R7T5) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 570 Score = 119 bits (299), Expect = 2e-27 Identities = 52/117 (44%), Positives = 78/117 (66%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 V+ + Q++ G+ + H + +IHRD+K NIL++ G +K+CDFG +R +P + YT V Sbjct: 103 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 T WYRAPELL+G +Y A+D+W++GC++ E+ +PLF G DIDQL I LG Sbjct: 163 ATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLG 219
>CDKL2_PONPY (Q5R754) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 493 Score = 119 bits (299), Expect = 2e-27 Identities = 52/117 (44%), Positives = 78/117 (66%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 V+ + Q++ G+ + H + +IHRD+K NIL++ G +K+CDFG +R +P + YT V Sbjct: 103 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSKSGVVKLCDFGFARTLAAPGEVYTDYV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 T WYRAPELL+G +Y A+D+W++GC++ E+ +PLF G DIDQL I LG Sbjct: 163 ATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLG 219
>CDKL2_HUMAN (Q92772) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE) Length = 493 Score = 119 bits (299), Expect = 2e-27 Identities = 52/117 (44%), Positives = 78/117 (66%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 V+ + Q++ G+ + H + +IHRD+K NIL++ G +K+CDFG +R +P + YT V Sbjct: 103 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 T WYRAPELL+G +Y A+D+W++GC++ E+ +PLF G DIDQL I LG Sbjct: 163 ATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLG 219
>HOG1_ASHGO (Q750A9) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 119 bits (299), Expect = 2e-27 Identities = 59/130 (45%), Positives = 86/130 (66%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 +P + ++ + Q+L G+KY+H VIHRDLK SNIL+N +LKICDFGL+R + Sbjct: 114 RPLEKQFLQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQM 173 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T +YRAPE++L ++Y+ +D+WS GCI AE++ KPLF GK + Q S I Sbjct: 174 TGY---VSTRYYRAPEIMLTWQKYNVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIIT 230 Query: 364 RMLGTPNEDI 393 +LG+P +D+ Sbjct: 231 DLLGSPPKDV 240
>HOG1_ZYGRO (O93982) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 380 Score = 119 bits (297), Expect = 4e-27 Identities = 59/130 (45%), Positives = 84/130 (64%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 +P + V+ + Q+L G+KY+H VIHRDLK SNIL+N +LKICDFGL+R + Sbjct: 114 RPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQM 173 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T +YRAPE++L ++Y +D+WS GCI +E++ KPLF GK + Q S I Sbjct: 174 TGY---VSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFSEMIEGKPLFPGKDHVHQFSIIT 230 Query: 364 RMLGTPNEDI 393 +LG+P D+ Sbjct: 231 DLLGSPPRDV 240
>KSS1_YEAST (P14681) Mitogen-activated protein kinase KSS1 (EC 2.7.11.24) (MAP| kinase KSS1) (Kinase suppressor of SST2) Length = 368 Score = 118 bits (295), Expect = 6e-27 Identities = 61/131 (46%), Positives = 84/131 (64%), Gaps = 7/131 (5%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP- 189 S V+ Q+L +K +H VIHRD+K SN+LLN+ +LK+CDFGL+R S Sbjct: 116 SDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSR 175 Query: 190 ------YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 T+ V T WYRAPE++L +EY+TA+D+WS GCI+AE++S KPLF G+ QL Sbjct: 176 ETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQL 235 Query: 352 SKIFRMLGTPN 384 I +LGTP+ Sbjct: 236 WLILEVLGTPS 246
>HOG1_CANGA (Q6FIU2) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 118 bits (295), Expect = 6e-27 Identities = 59/130 (45%), Positives = 83/130 (63%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 +P + V+ Q+L G+KY+H V+HRDLK SNIL+N +LKICDFGL+R + Sbjct: 114 RPLEKQFVQYFHYQILRGLKYVHSAGVVHRDLKPSNILINENCDLKICDFGLARIQDPQM 173 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T +YRAPE++L ++Y +D+WS GCI AE++ KPLF GK + Q S I Sbjct: 174 TGY---VSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIIT 230 Query: 364 RMLGTPNEDI 393 +LG+P D+ Sbjct: 231 DLLGSPPSDV 240
>CDKL4_MOUSE (Q3TZA2) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 342 Score = 117 bits (294), Expect = 8e-27 Identities = 56/121 (46%), Positives = 80/121 (66%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S +K ++ Q L+ + + H + IHRD+K NIL+ G +KICDFG +R P Y Sbjct: 99 SDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARIL-IPGDAY 157 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 T V T WYRAPELL+G +Y +++D+W++GC+ AELL+ +PL+ GK D+DQL I R L Sbjct: 158 TDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTL 217 Query: 373 G 375 G Sbjct: 218 G 218
>MK14B_BRARE (Q9DGE1) Mitogen-activated protein kinase 14b (EC 2.7.11.24)| (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (zp38b) Length = 348 Score = 117 bits (294), Expect = 8e-27 Identities = 59/126 (46%), Positives = 81/126 (64%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 Q + V+ L+ Q+L +KY+H +IHRDLK SN+ +N ELKI DFGL+R + Sbjct: 121 QKLTDDHVQFLIYQILRALKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARLTDDEM 180 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T WYRAPE++L Y+ +D+WS+GCIMAELL+ + LF G I+QL +I Sbjct: 181 TGY---VATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIM 237 Query: 364 RMLGTP 381 R+ GTP Sbjct: 238 RLTGTP 243
>STY1_SCHPO (Q09892) Mitogen-activated protein kinase sty1 (EC 2.7.11.24) (MAP| kinase sty1) (MAP kinase spc1) Length = 349 Score = 117 bits (293), Expect = 1e-26 Identities = 57/130 (43%), Positives = 85/130 (65%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPL 183 +P ++ + Q+L G+K++H VIHRDLK SNIL+N +LKICDFGL+R + Sbjct: 111 RPLETQFIQYFLYQILRGLKFVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQM 170 Query: 184 KPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIF 363 Y V T +YRAPE++L ++Y+ +D+WS GCI AE++ KPLF G+ ++Q S I Sbjct: 171 TGY---VSTRYYRAPEIMLTWQKYNVEVDIWSAGCIFAEMIEGKPLFPGRDHVNQFSIIT 227 Query: 364 RMLGTPNEDI 393 +LGTP ++ Sbjct: 228 ELLGTPPMEV 237
>CDKL4_HUMAN (Q5MAI5) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 315 Score = 116 bits (291), Expect = 2e-26 Identities = 55/117 (47%), Positives = 79/117 (67%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 +K ++ Q L+ + + H + IHRD+K NIL+ G +KICDFG + Q P YT V Sbjct: 103 IKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFA-QILIPGDAYTDYV 161 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 T WYRAPELL+G +Y +++D+W++GC+ AELL+ +PL+ GK D+DQL I R LG Sbjct: 162 ATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG 218
>FUS3_YEAST (P16892) Mitogen-activated protein kinase FUS3 (EC 2.7.11.24) (MAP| kinase FUS3) Length = 353 Score = 116 bits (291), Expect = 2e-26 Identities = 60/139 (43%), Positives = 86/139 (61%), Gaps = 10/139 (7%) Frame = +1 Query: 4 QPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSR------ 165 Q S ++ + Q L VK LH + VIHRDLK SN+L+N+ +LK+CDFGL+R Sbjct: 107 QMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESA 166 Query: 166 ----QYGSPLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGK 333 + T+ V T WYRAPE++L + +YS A+D+WS GCI+AEL ++P+F G+ Sbjct: 167 ADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGR 226 Query: 334 RDIDQLSKIFRMLGTPNED 390 QL IF ++GTP+ D Sbjct: 227 DYRHQLLLIFGIIGTPHSD 245
>MK15_MOUSE (Q80Y86) Mitogen-activated protein kinase 15 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 7) Length = 549 Score = 116 bits (290), Expect = 2e-26 Identities = 59/138 (42%), Positives = 84/138 (60%), Gaps = 9/138 (6%) Frame = +1 Query: 28 KCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGS-PLKP----Y 192 +C+ QLL K++H VIHRD K +N+LL++ +K+CDFGL+R G P P Sbjct: 116 RCIFYQLLRATKFIHSGRVIHRDQKPANVLLDSACRVKLCDFGLARSLGDLPEGPGGQAL 175 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 T+ V T WYRAPE+LL ++ Y+ +DMWSLGCI+ E+L +PLF G QL I + + Sbjct: 176 TEYVATRWYRAPEVLLSSRWYTPGVDMWSLGCILGEMLRGQPLFPGTSTFHQLELILKTI 235 Query: 373 GTPN----EDIWPGYSKL 414 P+ +D+ YS L Sbjct: 236 PLPSMEELQDLGSDYSAL 253
>CDKL1_BRARE (Q6AXJ9) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 350 Score = 116 bits (290), Expect = 2e-26 Identities = 55/117 (47%), Positives = 74/117 (63%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK ++ Q L+ V + H IHRD+K NIL+ +K+CDFG +R P YT V Sbjct: 103 VKSIIWQTLQAVNFCHKQNCIHRDVKPENILITKHQVIKLCDFGFARILTGPCDYYTDCV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 T WYRAPELL+G +Y +D+W++GC+ AELLS PL+ GK D+DQL I + LG Sbjct: 163 ATRWYRAPELLVGDTQYGPPVDVWAVGCVFAELLSGAPLWPGKSDVDQLYLIRKTLG 219
>KKQ1_YEAST (P36005) Probable serine/threonine-protein kinase YKL161C (EC| 2.7.11.1) Length = 433 Score = 115 bits (289), Expect = 3e-26 Identities = 56/134 (41%), Positives = 87/134 (64%), Gaps = 4/134 (2%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSP 180 +Q + + + Q+L +KY+H V+H DLK N+L+N+ +LKIC+FGLS Y Sbjct: 122 EQRLEDAHFQSFIYQILCALKYIHSANVLHCDLKPKNLLVNSDCQLKICNFGLSCSYSEN 181 Query: 181 LKPYTQLV----VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQ 348 K + ++WY+APE+LL +E + A+D+WS GCI+AELL +KP+F+GK +D Sbjct: 182 HKVNDGFIKGYITSIWYKAPEILLNYQECTKAVDIWSTGCILAELLGRKPMFEGKDYVDH 241 Query: 349 LSKIFRMLGTPNED 390 L+ I ++LGTP E+ Sbjct: 242 LNHILQILGTPPEE 255
>CDKL1_HUMAN (Q00532) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIALRE) (Protein kinase p42 KKIALRE) Length = 357 Score = 115 bits (288), Expect = 4e-26 Identities = 54/117 (46%), Positives = 74/117 (63%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + Q L+ V + H + IHRD+K NIL+ +K+CDFG +R P YT V Sbjct: 103 VKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 T WYR+PELL+G +Y +D+W++GC+ AELLS PL+ GK D+DQL I + LG Sbjct: 163 ATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG 219
>MK14C_DROME (P83100) Putative mitogen-activated protein kinase 14C (EC| 2.7.11.24) (MAP kinase p38c) Length = 356 Score = 115 bits (288), Expect = 4e-26 Identities = 54/132 (40%), Positives = 84/132 (63%) Frame = +1 Query: 13 SQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPY 192 S E++ ++ Q+L G+KY+H V+HRDLK NI +N E++I DFGLSR + Sbjct: 120 SDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRMCADKM--- 176 Query: 193 TQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRML 372 T V T+WY APE++ +Y+ AID+WS+GCI+AEL++ + LF G+ + Q+ + ++ Sbjct: 177 TDHVGTMWYLAPEIIFLRGQYTKAIDVWSVGCILAELITDRVLFRGENYVSQIRCLINIM 236 Query: 373 GTPNEDIWPGYS 408 GTP + G S Sbjct: 237 GTPTREFITGIS 248
>MDS1_YEAST (P38615) Serine/threonine-protein kinase MDS1/RIM11 (EC 2.7.11.1)| Length = 370 Score = 115 bits (287), Expect = 5e-26 Identities = 58/131 (44%), Positives = 86/131 (65%), Gaps = 2/131 (1%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNW-VIHRDLKTSNILLN-NCGELKICDFGLSRQYG 174 + P S+ E+K M QL + + YLH V HRD+K N+L++ LK+CDFG ++Q Sbjct: 132 RTPMSRLEIKYYMFQLFKSLNYLHHFANVCHRDIKPQNLLVDPETWSLKLCDFGSAKQL- 190 Query: 175 SPLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLS 354 P +P + + +YRAPEL+ GA Y+ ID+WS GC+MAELL +P+F G+ IDQL Sbjct: 191 KPTEPNVSYICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGESGIDQLV 250 Query: 355 KIFRMLGTPNE 387 +I ++LGTP++ Sbjct: 251 EIIKILGTPSK 261
>CDKL1_MOUSE (Q8CEQ0) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 114 bits (285), Expect = 9e-26 Identities = 54/117 (46%), Positives = 74/117 (63%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + Q L+ V + H + IHRD+K NIL+ +K+CDFG +R P YT V Sbjct: 103 VKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQSAIKLCDFGFARLLTGPGDYYTDYV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 T WYR+PELL+G +Y +D+W++GC+ AELLS PL+ GK D+DQL I + LG Sbjct: 163 ATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG 219
>CDKL1_RAT (Q66HE7) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 114 bits (284), Expect = 1e-25 Identities = 54/117 (46%), Positives = 74/117 (63%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLV 204 VK + Q L+ V + H + IHRD+K NIL+ +K+CDFG +R P YT V Sbjct: 103 VKNITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPGDYYTDYV 162 Query: 205 VTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG 375 T WYR+PELL+G +Y +D+W++GC+ AELLS PL+ GK D+DQL I + LG Sbjct: 163 ATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG 219
>CDKL5_HUMAN (O76039) Cyclin-dependent kinase-like 5 (EC 2.7.11.22)| (Serine/threonine-protein kinase 9) Length = 1030 Score = 114 bits (284), Expect = 1e-25 Identities = 58/131 (44%), Positives = 86/131 (65%), Gaps = 2/131 (1%) Frame = +1 Query: 22 EVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKP-YTQ 198 +VK + QL++ + + H N ++HRD+K N+L+++ LK+CDFG +R YT+ Sbjct: 111 KVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTE 170 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLG- 375 V T WYR+PELLLGA Y ++DMWS+GCI+ EL +PLF G+ +IDQL I ++LG Sbjct: 171 YVATRWYRSPELLLGAP-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGP 229 Query: 376 TPNEDIWPGYS 408 P+E + YS Sbjct: 230 LPSEQMKLFYS 240
>MK15_HUMAN (Q8TD08) Mitogen-activated protein kinase 15 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 8) Length = 544 Score = 113 bits (282), Expect = 2e-25 Identities = 56/127 (44%), Positives = 78/127 (61%), Gaps = 5/127 (3%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGS-PLKP---- 189 V+ + QLL ++LH V+HRD K SN+LL+ +K+CDFGL+R G P P Sbjct: 114 VRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQA 173 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 T+ V T WYRAPE+LL + Y+ +DMWSLGCI+ E+L +PLF G + QL I Sbjct: 174 VTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILET 233 Query: 370 LGTPNED 390 + P+E+ Sbjct: 234 IPPPSEE 240
>GSK3_SCHPO (Q10452) Protein kinase gsk3 (EC 2.7.11.1) (Protein kinaae skp1)| Length = 387 Score = 113 bits (282), Expect = 2e-25 Identities = 56/124 (45%), Positives = 84/124 (67%), Gaps = 1/124 (0%) Frame = +1 Query: 22 EVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLN-NCGELKICDFGLSRQYGSPLKPYTQ 198 EVK + QLL + Y+H + + HRD+K N+LL+ G LK+CDFG ++ + +P Sbjct: 133 EVKLYIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKILVAG-EPNVS 191 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 + + +YRAPEL+ GA +Y+ AID+WS GC+MAEL+ PLF G+ IDQL +I ++LGT Sbjct: 192 YICSRYYRAPELIFGATDYTHAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGT 251 Query: 379 PNED 390 P+ + Sbjct: 252 PSRE 255
>GSK3B_RAT (P18266) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) (Factor A) (FA) Length = 420 Score = 112 bits (279), Expect = 5e-25 Identities = 55/131 (41%), Positives = 83/131 (63%), Gaps = 1/131 (0%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLN-NCGELKICDFGLSRQYGS 177 KQ VK M QL + Y+H + HRD+K N+LL+ + LK+CDFG ++Q Sbjct: 150 KQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR 209 Query: 178 PLKPYTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSK 357 +P + + +YRAPEL+ GA +Y+++IDMWS GC++AELL +P+F G +DQL + Sbjct: 210 G-EPNVSYICSRYYRAPELIFGATDYTSSIDMWSAGCVLAELLLGQPIFPGDSGVDQLVE 268 Query: 358 IFRMLGTPNED 390 I ++LGTP + Sbjct: 269 IIKVLGTPTRE 279
>YPC2_CAEEL (Q11179) Putative serine/threonine-protein kinase C05D10.2 in| chromosome III (EC 2.7.11.24) Length = 470 Score = 111 bits (278), Expect = 6e-25 Identities = 53/125 (42%), Positives = 77/125 (61%), Gaps = 8/125 (6%) Frame = +1 Query: 34 LMLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQY--------GSPLKP 189 +M QL +++LH V+HRDLK SN+LL+ +K+ DFGL+R G + Sbjct: 117 IMCQLFRAIRFLHSGNVLHRDLKPSNVLLDADCRVKLADFGLARSLSSLEDYPEGQKMPD 176 Query: 190 YTQLVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRM 369 T+ V T WYR+PE+LL AK Y+ +DMWSLGCI+AE+L + LF G I+Q+ +I Sbjct: 177 LTEYVATRWYRSPEILLAAKRYTKGVDMWSLGCILAEMLIGRALFPGSSTINQIERIMNT 236 Query: 370 LGTPN 384 + P+ Sbjct: 237 IAKPS 241
>CDKL3_MOUSE (Q8BLF2) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| Length = 595 Score = 111 bits (277), Expect = 8e-25 Identities = 51/127 (40%), Positives = 75/127 (59%) Frame = +1 Query: 37 MLQLLEGVKYLHDNWVIHRDLKTSNILLNNCGELKICDFGLSRQYGSPLKPYTQLVVTLW 216 + Q+L ++YLH+N +IHRD+K NIL++ G K+CDFG +R +P YT V T W Sbjct: 106 LFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRW 165 Query: 217 YRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGTPNEDIW 396 YRAPEL+L Y +D+W+LGC++ E+ + P D+D L KI +G + Sbjct: 166 YRAPELVLKDTSYGKPVDIWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVGNLTPHLH 225 Query: 397 PGYSKLP 417 +SK P Sbjct: 226 NIFSKSP 232
>KSG10_ARATH (Q39019) Shaggy-related protein kinase kappa (EC 2.7.11.1)| (ASK-kappa) (AtK-1) Length = 421 Score = 111 bits (277), Expect = 8e-25 Identities = 55/124 (44%), Positives = 84/124 (67%), Gaps = 2/124 (1%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNW-VIHRDLKTSNILLN-NCGELKICDFGLSRQYGSPLKPYTQ 198 VK Q+ + Y+H+++ + HRD+K N+L+N + +LKICDFG ++ +P Sbjct: 184 VKLYTYQICRALAYIHNSFGLCHRDIKPQNLLVNPHTHQLKICDFGSAKVLVKG-EPNVS 242 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 + + +YRAPEL+ GA EY+TAID+WS GC+MAELL +PLF G+ +DQL +I ++LGT Sbjct: 243 YICSRYYRAPELIFGASEYTTAIDIWSTGCVMAELLLGQPLFPGESGVDQLVEIIKVLGT 302 Query: 379 PNED 390 P + Sbjct: 303 PTRE 306
>GSK3H_DICDI (P51136) Glycogen synthase kinase-3 homolog (EC 2.7.11.26) (GSK-3)| Length = 467 Score = 110 bits (276), Expect = 1e-24 Identities = 57/133 (42%), Positives = 85/133 (63%), Gaps = 3/133 (2%) Frame = +1 Query: 1 KQPYSQSEVKCLMLQLLEGVKYLHDNWVIHRDLKTSNILLN-NCGELKICDFGLSRQYGS 177 KQP VK + QL + Y+H + HRD+K N+LL+ + LK+CDFG ++ Sbjct: 148 KQPVPNIFVKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTSTSTLKLCDFGSAKIL-- 205 Query: 178 PLKPYTQL--VVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQL 351 +K T + + + YRAPEL+ G+ Y+T ID+WSLGC++AELL +PLF G+ IDQL Sbjct: 206 -IKGETNVSYICSRHYRAPELIFGSTNYTTTIDVWSLGCVLAELLLGQPLFPGENGIDQL 264 Query: 352 SKIFRMLGTPNED 390 +I ++LGTP ++ Sbjct: 265 VEIIKVLGTPTKE 277
>KSG4_ARATH (Q9FVS6) Shaggy-related protein kinase delta (EC 2.7.11.1)| (ASK-delta) Length = 420 Score = 110 bits (276), Expect = 1e-24 Identities = 57/124 (45%), Positives = 83/124 (66%), Gaps = 2/124 (1%) Frame = +1 Query: 25 VKCLMLQLLEGVKYLHDNW-VIHRDLKTSNILLN-NCGELKICDFGLSRQYGSPLKPYTQ 198 VK Q+ G+ YLH+ + HRD+K N+L+N + +LKICDFG ++ +P Sbjct: 183 VKLYTYQICRGLAYLHNCCGLCHRDIKPQNLLVNPHTHQLKICDFGSAKVLVKG-EPNIS 241 Query: 199 LVVTLWYRAPELLLGAKEYSTAIDMWSLGCIMAELLSKKPLFDGKRDIDQLSKIFRMLGT 378 + + +YRAPEL+ GA EY+TAID+WS GC+MAELL +PLF G+ +DQL +I ++LGT Sbjct: 242 YICSRYYRAPELIFGATEYTTAIDIWSTGCVMAELLLGQPLFPGESGVDQLVEIIKVLGT 301 Query: 379 PNED 390 P + Sbjct: 302 PTRE 305 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 59,849,976 Number of Sequences: 219361 Number of extensions: 1177143 Number of successful extensions: 6342 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 4804 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5020 length of database: 80,573,946 effective HSP length: 100 effective length of database: 58,637,846 effective search space used: 2286875994 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
