>CAS1_ARATH (P38605) Cycloartenol synthase (EC 5.4.99.8)|
           (2,3-epoxysqualene--cycloartenol cyclase)
          Length = 759

 Score =  171 bits (433), Expect(2) = 2e-54
 Identities = 77/154 (50%), Positives = 112/154 (72%)
 Frame = +2

Query: 194 RFEKRESQDLLMRMQYAKLNPLPAIVPKVHLDDNAEVTEEIISASLRQALNQYCTLQAHD 373
           RF ++ S DLLMR+Q+++ N +  ++P+V ++D  +VTEE++  +L++ L+ Y T+QAHD
Sbjct: 52  RFVQKHSADLLMRLQFSRENLISPVLPQVKIEDTDDVTEEMVETTLKRGLDFYSTIQAHD 111

Query: 374 GHWPGDNSGIMFLMPMFIFSLYVTENLHSVISSDHQREICRHIYNHQNEDGGWGTHVIGP 553
           GHWPGD  G MFL+P  I +L +T  L++V+S  H++E+ R++YNHQNEDGGWG H+ GP
Sbjct: 112 GHWPGDYGGPMFLLPGLIITLSITGALNTVLSEQHKQEMRRYLYNHQNEDGGWGLHIEGP 171

Query: 554 SNMLCSCLNYAALRLLGEMLDCDNGALAKGRAWI 655
           S M  S LNY  LRLLGE  +  +G + KGR WI
Sbjct: 172 STMFGSVLNYVTLRLLGEGPNDGDGDMEKGRDWI 205



 Score = 61.2 bits (147), Expect(2) = 2e-54
 Identities = 23/35 (65%), Positives = 30/35 (85%)
 Frame = +1

Query: 40  MWRLKVSEGGSPWLRSPSSFLGRAVWEFDPELGTP 144
           MW+LK++EGGSPWLR+ ++ +GR  WEFDP LGTP
Sbjct: 1   MWKLKIAEGGSPWLRTTNNHVGRQFWEFDPNLGTP 35

>ERG7_PNECA (Q96WJ0) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 719

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 38/95 (40%), Positives = 57/95 (60%), Gaps = 2/95 (2%)
 Frame = +2

Query: 326 SLRQALNQYCTLQAHDGHWPGDNSGIMFLMPMFIFSLYVTENLHSVISSDHQR-EICRHI 502
           S R+  + Y  LQ  DG+W  +  G+MFL+P  I ++Y+++    +   D  R E+ R++
Sbjct: 70  SARKGFSFYKHLQTSDGNWACEYGGVMFLLPGLIIAMYISK----IEFPDEMRIEVIRYL 125

Query: 503 YNHQN-EDGGWGTHVIGPSNMLCSCLNYAALRLLG 604
            NH N EDGGWG H+ G S +  + LNY  LR+LG
Sbjct: 126 VNHANPEDGGWGIHIEGKSTVFGTALNYVVLRILG 160



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 1/73 (1%)
 Frame = +2

Query: 317 ISASLRQALNQYCTLQAHDGHWPGDNSGIMFLMPMFIF-SLYVTENLHSVISSDHQREIC 493
           I+ S++ A+      Q  DG W    +       MF   SL   ++ +   +S H R  C
Sbjct: 551 INKSVKNAIQFIKESQRPDGSWYESWAICFTYATMFALESLSCVKDFYE--NSFHSRRAC 608

Query: 494 RHIYNHQNEDGGW 532
             + N Q EDGGW
Sbjct: 609 DFLVNKQEEDGGW 621

>ERG7_MOUSE (Q8BLN5) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 733

 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 33/85 (38%), Positives = 52/85 (61%)
 Frame = +2

Query: 350 YCTLQAHDGHWPGDNSGIMFLMPMFIFSLYVTENLHSVISSDHQREICRHIYNHQNEDGG 529
           Y  LQA DGHW GD  G +FL+P  + + +++   H  + + ++ E+ R++ + Q  DGG
Sbjct: 85  YAKLQAEDGHWAGDYGGPLFLLPGLLITCHIS---HISLPAGYREEMVRYLRSVQLPDGG 141

Query: 530 WGTHVIGPSNMLCSCLNYAALRLLG 604
           WG H+   S +  + LNY ALR+LG
Sbjct: 142 WGLHIEDKSTVFGTALNYVALRILG 166

>ERG7_RAT (P48450) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 733

 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 31/85 (36%), Positives = 51/85 (60%)
 Frame = +2

Query: 350 YCTLQAHDGHWPGDNSGIMFLMPMFIFSLYVTENLHSVISSDHQREICRHIYNHQNEDGG 529
           Y  LQA DGHW GD  G +FL+P  + + ++    H  + + ++ E+ R++ + Q  DGG
Sbjct: 85  YAKLQAEDGHWAGDYGGPLFLLPGLLITCHIA---HIPLPAGYREEMVRYLRSVQLPDGG 141

Query: 530 WGTHVIGPSNMLCSCLNYAALRLLG 604
           WG H+   S +  + L+Y +LR+LG
Sbjct: 142 WGLHIEDKSTVFGTALSYVSLRILG 166

>ERG7_HUMAN (P48449) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 732

 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 33/85 (38%), Positives = 50/85 (58%)
 Frame = +2

Query: 350 YCTLQAHDGHWPGDNSGIMFLMPMFIFSLYVTENLHSVISSDHQREICRHIYNHQNEDGG 529
           Y  LQA DGHW GD  G +FL+P  + + +V       + + ++ EI R++ + Q  DGG
Sbjct: 84  YVGLQAEDGHWTGDYGGPLFLLPGLLITCHVAR---IPLPAGYREEIVRYLRSVQLPDGG 140

Query: 530 WGTHVIGPSNMLCSCLNYAALRLLG 604
           WG H+   S +  + LNY +LR+LG
Sbjct: 141 WGLHIEDKSTVFGTALNYVSLRILG 165

>ERG7_SCHPO (Q10231) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 721

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 31/82 (37%), Positives = 46/82 (56%)
 Frame = +2

Query: 359 LQAHDGHWPGDNSGIMFLMPMFIFSLYVTENLHSVISSDHQREICRHIYNHQNEDGGWGT 538
           LQ  DGHW     G MFL+   +F+ Y+++   +        EI +++ NH N+DGGWG 
Sbjct: 84  LQLPDGHWASPYEGPMFLICGAVFAFYISQ---TPFPKGWAPEIIQYLINHTNDDGGWGI 140

Query: 539 HVIGPSNMLCSCLNYAALRLLG 604
           H  G S +  + +NY  LR+LG
Sbjct: 141 HTEGVSTVFGTSMNYVVLRILG 162

>ERG7_CANAL (Q04782) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 728

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 36/99 (36%), Positives = 51/99 (51%), Gaps = 3/99 (3%)
 Frame = +2

Query: 359 LQAHDGHWPGDNSGIMFLMPMFIFSLYVTENLHSV--ISSDHQREICRHIYNHQNE-DGG 529
           LQ  +G +P    G     PMF+   YVT N +S   I   ++ E+ R+I N  +  DGG
Sbjct: 80  LQLDNGIFPCQYKG-----PMFMTIGYVTANYYSKTEIPEPYRVEMIRYIVNTAHPVDGG 134

Query: 530 WGTHVIGPSNMLCSCLNYAALRLLGEMLDCDNGALAKGR 646
           WG H +  S    + +NY  LRLLG  ++ D+  L K R
Sbjct: 135 WGLHSVDKSTCFGTTMNYVCLRLLG--MEKDHPVLVKAR 171

>ERG7_YEAST (P38604) Lanosterol synthase (EC 5.4.99.7)|
           (Oxidosqualene--lanosterol cyclase)
           (2,3-epoxysqualene--lanosterol cyclase) (OSC)
          Length = 730

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 33/81 (40%), Positives = 45/81 (55%), Gaps = 3/81 (3%)
 Frame = +2

Query: 416 PMFIFSLYVTENLHSVIS-SDHQR-EICRHIYNHQNE-DGGWGTHVIGPSNMLCSCLNYA 586
           PMF+   YV  N  + I   +H+R E+ R+I N  +  DGGWG H +  S +  + LNY 
Sbjct: 101 PMFMTIGYVAVNYIAGIEIPEHERIELIRYIVNTAHPVDGGWGLHSVDKSTVFGTVLNYV 160

Query: 587 ALRLLGEMLDCDNGALAKGRA 649
            LRLLG  L  D+   AK R+
Sbjct: 161 ILRLLG--LPKDHPVCAKARS 179



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 4/80 (5%)
 Frame = +2

Query: 308 EEIISASLRQALNQYCTLQAHDGHWPGDNSGIMFLMPMFIFSLYVTENLHSV----ISSD 475
           +E I   +R A+      Q  DG W G + GI F        ++  E LH+V     +S 
Sbjct: 558 KEEIRTRIRIAIEFIKKSQLPDGSWYG-SWGICFTYA----GMFALEALHTVGETYENSS 612

Query: 476 HQREICRHIYNHQNEDGGWG 535
             R+ C  + + Q +DGGWG
Sbjct: 613 TVRKGCDFLVSKQMKDGGWG 632

>SQHC_ALIAC (P33247) Squalene--hopene cyclase (EC 5.4.99.17)|
          Length = 630

 Score = 38.5 bits (88), Expect = 0.018
 Identities = 21/97 (21%), Positives = 45/97 (46%)
 Frame = +2

Query: 326 SLRQALNQYCTLQAHDGHWPGDNSGIMFLMPMFIFSLYVTENLHSVISSDHQREICRHIY 505
           +L +A+    + Q  +G+W G     + +   ++   ++ +     +  D   +I R++ 
Sbjct: 13  TLDRAVEYLLSCQKDEGYWWGPLLSNVTMEAEYVLLCHILDR----VDRDRMEKIRRYLL 68

Query: 506 NHQNEDGGWGTHVIGPSNMLCSCLNYAALRLLGEMLD 616
           + Q EDG W  +  GP ++  +   Y AL+ +G   D
Sbjct: 69  HEQREDGTWALYPGGPPDLDTTIEAYVALKYIGMSRD 105

>Y984_THEMA (Q9X079) Hypothetical UPF0192 protein TM0984 precursor|
          Length = 1536

 Score = 30.8 bits (68), Expect = 3.7
 Identities = 16/43 (37%), Positives = 25/43 (58%)
 Frame = +2

Query: 446  ENLHSVISSDHQREICRHIYNHQNEDGGWGTHVIGPSNMLCSC 574
            ENL  +I    QR + + +Y++Q+ DGGWG    G S+   +C
Sbjct: 941  ENLEEII----QRGLFK-LYSYQHNDGGWGWFRFGESDDFMTC 978

>Y1503_PASMU (Q9CKV2) Hypothetical protein PM1503|
          Length = 289

 Score = 29.6 bits (65), Expect = 8.2
 Identities = 14/28 (50%), Positives = 17/28 (60%)
 Frame = +3

Query: 9  LLPPYAGHLXXVEAEGVGGRQPVAAFPE 92
          +L PYA HL  V AE   G  P+A FP+
Sbjct: 1  MLTPYAYHLVNVFAETYFGGNPLAVFPQ 28

>ASPX_VULVU (P53353) Sperm acrosomal protein FSA-ACR.1 precursor (Fragment)|
          Length = 349

 Score = 29.6 bits (65), Expect = 8.2
 Identities = 16/50 (32%), Positives = 22/50 (44%)
 Frame = -3

Query: 197 NGTACSLGATSQPLRXXXXXXXXXSNSHTALPRKLLGERSHGLPPSDTFS 48
           +G   S+   S             ++S  A   K LGE+  G+PPS TFS
Sbjct: 219 SGEQASIEKASSEQASAEQASAEQASSEQASGEKPLGEQPSGIPPSSTFS 268


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,048,847
Number of Sequences: 219361
Number of extensions: 2145588
Number of successful extensions: 5143
Number of sequences better than 10.0: 12
Number of HSP's better than 10.0 without gapping: 4932
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5133
length of database: 80,573,946
effective HSP length: 108
effective length of database: 56,882,958
effective search space used: 6200242422
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)