ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags9a17 |
|---|---|
| Clone Library Name | barley_pub |
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 125 bits (314), Expect = 1e-28 Identities = 73/191 (38%), Positives = 113/191 (59%), Gaps = 7/191 (3%) Frame = +3 Query: 3 AVXXLSNTHMY-EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQR 179 AV LS T + EF V + ++H N+V+ LG C + ++ Sbjct: 554 AVKRLSKTSVQGTDEFMNEVTLIARLQHINLVQVLGCCIEGD----------------EK 597 Query: 180 LLCFEYLPNGSLDKYITDTSR--KVQWRKCFQIIKGICQGLHYLHQRN---ILHLDLKPA 344 +L +EYL N SLD Y+ +R K+ W + F I G+ +GL YLHQ + I+H DLK + Sbjct: 598 MLIYEYLENLSLDSYLFGKTRRSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKVS 657 Query: 345 NILLDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVG 521 NILLD N++PKI+DFG++R F ++ A T+ + GT GY++PE+ G + + D++S G Sbjct: 658 NILLDKNMIPKISDFGMARIFERDETEANTMKVVGTYGYMSPEYAMYGIFSEKSDVFSFG 717 Query: 522 VIIIEILTGKK 554 VI++EI++GKK Sbjct: 718 VIVLEIVSGKK 728
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 117 bits (294), Expect = 2e-26 Identities = 68/179 (37%), Positives = 106/179 (59%), Gaps = 7/179 (3%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 +EF +E L VKH N+V LGYC+ ++ ++LL +EY+ NGSLD Sbjct: 956 REFMAEMETLGKVKHPNLVSLLGYCSFSE----------------EKLLVYEYMVNGSLD 999 Query: 219 KYITDTSRKVQ---WRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLVPKI 380 ++ + + ++ W K +I G +GL +LH +I+H D+K +NILLDG+ PK+ Sbjct: 1000 HWLRNQTGMLEVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKV 1059 Query: 381 ADFGVSRCFHEMQSRAITVNIRGTLGYLAPEF-CNGEITYQLDIYSVGVIIIEILTGKK 554 ADFG++R +S TV I GT GY+ PE+ + T + D+YS GVI++E++TGK+ Sbjct: 1060 ADFGLARLISACESHVSTV-IAGTFGYIPPEYGQSARATTKGDVYSFGVILLELVTGKE 1117
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 115 bits (289), Expect = 9e-26 Identities = 70/192 (36%), Positives = 107/192 (55%), Gaps = 8/192 (4%) Frame = +3 Query: 3 AVXXLS-NTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQR 179 A+ LS +T ++EF VE L +H N+V LGYC N K + Sbjct: 769 AIKRLSGDTGQMDREFQAEVETLSRAQHPNLVHLLGYC----------NYK------NDK 812 Query: 180 LLCFEYLPNGSLDKYI---TDTSRKVQWRKCFQIIKGICQGLHYLHQR---NILHLDLKP 341 LL + Y+ NGSLD ++ D + W+ +I +G +GL YLHQ +ILH D+K Sbjct: 813 LLIYSYMDNGSLDYWLHEKVDGPPSLDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKS 872 Query: 342 ANILLDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEI-TYQLDIYSV 518 +NILL V +ADFG++R + +T ++ GTLGY+ PE+ + TY+ D+YS Sbjct: 873 SNILLSDTFVAHLADFGLARLILPYDTH-VTTDLVGTLGYIPPEYGQASVATYKGDVYSF 931 Query: 519 GVIIIEILTGKK 554 GV+++E+LTG++ Sbjct: 932 GVVLLELLTGRR 943
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 114 bits (284), Expect = 3e-25 Identities = 62/179 (34%), Positives = 104/179 (58%), Gaps = 8/179 (4%) Frame = +3 Query: 42 EFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDK 221 EF + L V+H+++V LGYC D ++LL +EY+P G+L + Sbjct: 630 EFKSEIAVLTKVRHRHLVTLLGYCLDGN----------------EKLLVYEYMPQGTLSR 673 Query: 222 YITDTSRK----VQWRKCFQIIKGICQGLHYLH---QRNILHLDLKPANILLDGNLVPKI 380 ++ + S + + W++ + + +G+ YLH ++ +H DLKP+NILL ++ K+ Sbjct: 674 HLFEWSEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKV 733 Query: 381 ADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTGKK 554 ADFG+ R E + +I I GT GYLAPE+ G +T ++D+YS GVI++E++TG+K Sbjct: 734 ADFGLVRLAPEGKG-SIETRIAGTFGYLAPEYAVTGRVTTKVDVYSFGVILMELITGRK 791
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 112 bits (280), Expect = 1e-24 Identities = 62/186 (33%), Positives = 104/186 (55%), Gaps = 7/186 (3%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 +EF V L + H N+V+ +G+CA+ QRLL +EY+P GSL+ Sbjct: 143 REFVVEVLTLSLADHPNLVKLIGFCAEGD----------------QRLLVYEYMPQGSLE 186 Query: 219 KYI---TDTSRKVQWRKCFQIIKGICQGLHYLHQRN---ILHLDLKPANILLDGNLVPKI 380 ++ + + W +I G +GL YLH R +++ DLK +NILL + PK+ Sbjct: 187 DHLHVLPSGKKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKL 246 Query: 381 ADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTGKKG 557 +DFG+++ ++ + GT GY AP++ G++T++ DIYS GV+++E++TG+K Sbjct: 247 SDFGLAKVGPSGDKTHVSTRVMGTYGYCAPDYAMTGQLTFKSDIYSFGVVLLELITGRK- 305 Query: 558 YLAVDN 575 A+DN Sbjct: 306 --AIDN 309
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 111 bits (277), Expect = 2e-24 Identities = 67/190 (35%), Positives = 100/190 (52%), Gaps = 6/190 (3%) Frame = +3 Query: 3 AVXXLSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRL 182 AV L N ++ F + + + H N+VR G+C++ GS RL Sbjct: 560 AVKKLENVRQGKEVFQAELSVIGRINHMNLVRIWGFCSE--GS--------------HRL 603 Query: 183 LCFEYLPNGSLDKYITDTSRKV--QWRKCFQIIKGICQGLHYLHQRN---ILHLDLKPAN 347 L EY+ NGSL + + W F I G+ +GL YLH ++H D+KP N Sbjct: 604 LVSEYVENGSLANILFSEGGNILLDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKPEN 663 Query: 348 ILLDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGV 524 ILLD PKI DFG+ + + S ++RGTLGY+APE+ + IT ++D+YS GV Sbjct: 664 ILLDQAFEPKITDFGLVKLLNRGGSTQNVSHVRGTLGYIAPEWVSSLPITAKVDVYSYGV 723 Query: 525 IIIEILTGKK 554 +++E+LTG + Sbjct: 724 VLLELLTGTR 733
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 110 bits (276), Expect = 3e-24 Identities = 57/178 (32%), Positives = 99/178 (55%), Gaps = 2/178 (1%) Frame = +3 Query: 21 NTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYL 200 +T +++F + ++ + +H+N+V LG+ +D+ L + Y+ Sbjct: 222 STEELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLC----------------LVYAYM 265 Query: 201 PNGSLDKYIT--DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVP 374 PNGSL ++ D + + W ++ +G G+ +LH+ + +H D+K ANILLD + Sbjct: 266 PNGSLLDRLSCLDGTPPLSWHTRCKVAQGTANGIRFLHENHHIHRDIKSANILLDKDFTA 325 Query: 375 KIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQLDIYSVGVIIIEILTG 548 KI+DFG++R + +T I GT Y+APE GEIT + DIYS GV+++E++TG Sbjct: 326 KISDFGLARASARLAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLELITG 383
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 109 bits (273), Expect = 6e-24 Identities = 59/177 (33%), Positives = 97/177 (54%), Gaps = 2/177 (1%) Frame = +3 Query: 24 THMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLP 203 T +++F + ++ + +H+N+V LG+ +D L + Y+P Sbjct: 223 TEELKQQFDQEIKVMAKCQHENLVELLGFSSDGD----------------DLCLVYVYMP 266 Query: 204 NGSLDKYIT--DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPK 377 NGSL ++ D + + W +I +G G+++LH+ + +H D+K ANILLD K Sbjct: 267 NGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAK 326 Query: 378 IADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQLDIYSVGVIIIEILTG 548 I+DFG++R + +T I GT Y+APE GEIT + DIYS GV+++EI+TG Sbjct: 327 ISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITG 383
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 109 bits (272), Expect = 8e-24 Identities = 65/180 (36%), Positives = 102/180 (56%), Gaps = 7/180 (3%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 E+EF VE L +H N+V G+C F D RLL + Y+ NGSL Sbjct: 772 EREFEAEVETLSRAQHPNLVLLRGFC-------------FYKND---RLLIYSYMENGSL 815 Query: 216 DKYI---TDTSRKVQWRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLVPK 377 D ++ D ++W+ +I +G +GL YLH+ +ILH D+K +NILLD N Sbjct: 816 DYWLHERNDGPALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSH 875 Query: 378 IADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTGKK 554 +ADFG++R ++ ++ ++ GTLGY+ PE+ + TY+ D+YS GV+++E+LT K+ Sbjct: 876 LADFGLARLMSPYETH-VSTDLVGTLGYIPPEYGQASVATYKGDVYSFGVVLLELLTDKR 934
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 108 bits (271), Expect = 1e-23 Identities = 59/179 (32%), Positives = 97/179 (54%), Gaps = 7/179 (3%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 +EF V L ++ H N+V +GYCAD QRLL +E++P GSL+ Sbjct: 126 REFLVEVLMLSLLHHPNLVNLIGYCADGD----------------QRLLVYEFMPLGSLE 169 Query: 219 KYITDT---SRKVQWRKCFQIIKGICQGLHYLHQRN---ILHLDLKPANILLDGNLVPKI 380 ++ D + W +I G +GL +LH + +++ D K +NILLD PK+ Sbjct: 170 DHLHDLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKL 229 Query: 381 ADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTGKK 554 +DFG+++ ++ + GT GY APE+ G++T + D+YS GV+ +E++TG+K Sbjct: 230 SDFGLAKLGPTGDKSHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYSFGVVFLELITGRK 288
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 106 bits (264), Expect = 7e-23 Identities = 56/172 (32%), Positives = 96/172 (55%), Gaps = 3/172 (1%) Frame = +3 Query: 42 EFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDK 221 E+ V L M+ H+N+V+ LGYC + + + LL +E++P GSL+ Sbjct: 136 EWRSEVNFLGMLSHRNLVKLLGYCREDK----------------ELLLVYEFMPKGSLES 179 Query: 222 YITDTSRKVQWRKCFQIIKGICQGLHYLH--QRNILHLDLKPANILLDGNLVPKIADFGV 395 ++ + W +I+ G +GL +LH QR +++ D K +NILLD N K++DFG+ Sbjct: 180 HLFRRNDPFPWDLRIKIVIGAARGLAFLHSLQREVIYRDFKASNILLDSNYDAKLSDFGL 239 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPEF-CNGEITYQLDIYSVGVIIIEILTG 548 ++ + +T I GT GY APE+ G + + D+++ GV+++EI+TG Sbjct: 240 AKLGPADEKSHVTTRIMGTYGYAAPEYMATGHLYVKSDVFAFGVVLLEIMTG 291
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 105 bits (262), Expect = 1e-22 Identities = 62/210 (29%), Positives = 111/210 (52%), Gaps = 12/210 (5%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 ++EF +E + +KH+N+V LGYC + +RLL +EY+ GSL Sbjct: 896 DREFMAEMETIGKIKHRNLVPLLGYCKIGE----------------ERLLVYEYMKYGSL 939 Query: 216 DKYITDTSRK----VQWRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLVP 374 + + + ++K + W +I G +GL +LH +I+H D+K +N+LLD + V Sbjct: 940 ETVLHEKTKKGGIFLDWSARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDQDFVA 999 Query: 375 KIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTGK 551 +++DFG++R + + + GT GY+ PE+ T + D+YS GVI++E+L+GK Sbjct: 1000 RVSDFGMARLVSALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGK 1059 Query: 552 KGY----LAVDNVVESWSNKLEKSQSDVQL 629 K DN + W+ +L + + ++ Sbjct: 1060 KPIDPEEFGEDNNLVGWAKQLYREKRGAEI 1089
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 105 bits (261), Expect = 2e-22 Identities = 60/180 (33%), Positives = 99/180 (55%), Gaps = 7/180 (3%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 ++EF +E + +KH+N+V LGYC + +RLL +EY+ GSL Sbjct: 926 DREFTAEMETIGKIKHRNLVPLLGYCKVGE----------------ERLLVYEYMKYGSL 969 Query: 216 DKYITD---TSRKVQWRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLVPK 377 + + D T K+ W +I G +GL +LH +I+H D+K +N+LLD NL + Sbjct: 970 EDVLHDRKKTGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEAR 1029 Query: 378 IADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTGKK 554 ++DFG++R M + + GT GY+ PE+ + + D+YS GV+++E+LTGK+ Sbjct: 1030 VSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQ 1089
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 104 bits (260), Expect = 2e-22 Identities = 63/211 (29%), Positives = 110/211 (52%), Gaps = 13/211 (6%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 ++EF +E + +KH+N+V LGYC + +RLL +EY+ GSL Sbjct: 897 DREFMAEMETIGKIKHRNLVPLLGYCKVGE----------------ERLLVYEYMKWGSL 940 Query: 216 DKYITDTSRK-----VQWRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLV 371 + + + S K + W +I G +GL +LH +I+H D+K +N+LLD + Sbjct: 941 ETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFE 1000 Query: 372 PKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTG 548 +++DFG++R + + + GT GY+ PE+ T + D+YS GVI++E+L+G Sbjct: 1001 ARVSDFGMARLVSALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSG 1060 Query: 549 KK----GYLAVDNVVESWSNKLEKSQSDVQL 629 KK G DN + W+ +L + + ++ Sbjct: 1061 KKPIDPGEFGEDNNLVGWAKQLYREKRGAEI 1091
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 104 bits (260), Expect = 2e-22 Identities = 59/180 (32%), Positives = 99/180 (55%), Gaps = 7/180 (3%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 ++EF +E + +KH+N+V LGYC + +RLL +EY+ GSL Sbjct: 926 DREFTAEMETIGKIKHRNLVPLLGYCKVGE----------------ERLLVYEYMKYGSL 969 Query: 216 DKYITDTSR---KVQWRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLVPK 377 + + D + K+ W +I G +GL +LH +I+H D+K +N+LLD NL + Sbjct: 970 EDVLHDRKKIGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEAR 1029 Query: 378 IADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTGKK 554 ++DFG++R M + + GT GY+ PE+ + + D+YS GV+++E+LTGK+ Sbjct: 1030 VSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKQ 1089
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 104 bits (260), Expect = 2e-22 Identities = 61/176 (34%), Positives = 96/176 (54%), Gaps = 5/176 (2%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 KEF V+ LM V H N+ +GYC + + +L +EY+ N +L Sbjct: 612 KEFRAEVDLLMRVHHTNLTSLVGYCNE----------------INHMVLIYEYMANENLG 655 Query: 219 KYITDT-SRKVQWRKCFQIIKGICQGLHYLH---QRNILHLDLKPANILLDGNLVPKIAD 386 Y+ S + W + +I QGL YLH + I+H D+KP NILL+ L K+AD Sbjct: 656 DYLAGKRSFILSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMAD 715 Query: 387 FGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILTGK 551 FG+SR F S I+ + G++GYL PE + ++ + D+YS+GV+++E++TG+ Sbjct: 716 FGLSRSFSVEGSGQISTVVAGSIGYLDPEYYSTRQMNEKSDVYSLGVVLLEVITGQ 771
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 103 bits (256), Expect = 6e-22 Identities = 59/180 (32%), Positives = 100/180 (55%), Gaps = 7/180 (3%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 ++EF +E + +KH+N+V LGYC + D +RLL +E++ GSL Sbjct: 921 DREFMAEMETIGKIKHRNLVPLLGYCK--------------VGD--ERLLVYEFMKYGSL 964 Query: 216 DKYITDTSR---KVQWRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLVPK 377 + + D + K+ W +I G +GL +LH +I+H D+K +N+LLD NL + Sbjct: 965 EDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEAR 1024 Query: 378 IADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTGKK 554 ++DFG++R M + + GT GY+ PE+ + + D+YS GV+++E+LTGK+ Sbjct: 1025 VSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKR 1084
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 102 bits (254), Expect = 1e-21 Identities = 58/182 (31%), Positives = 103/182 (56%), Gaps = 9/182 (4%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 ++EF +E L +KH+N+V LGYC + +RLL +E++ GSL Sbjct: 876 DREFMAEMETLGKIKHRNLVPLLGYCKIGE----------------ERLLVYEFMQYGSL 919 Query: 216 DKYI----TDTSRKVQ-WRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLV 371 ++ + T R++ W + +I KG +GL +LH +I+H D+K +N+LLD ++ Sbjct: 920 EEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDME 979 Query: 372 PKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTG 548 +++DFG++R + + + GT GY+ PE+ T + D+YS+GV+++EIL+G Sbjct: 980 ARVSDFGMARLISALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSIGVVMLEILSG 1039 Query: 549 KK 554 K+ Sbjct: 1040 KR 1041
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 101 bits (251), Expect = 2e-21 Identities = 56/179 (31%), Positives = 102/179 (56%), Gaps = 7/179 (3%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL- 215 +EF + L ++H+N+V LGYC + Q++L + ++ NGSL Sbjct: 635 REFDNELNLLSAIQHENLVPLLGYCNE----------------YDQQILVYPFMSNGSLL 678 Query: 216 DKYITDTSRK--VQWRKCFQIIKGICQGLHYLHQ---RNILHLDLKPANILLDGNLVPKI 380 D+ + S++ + W I G +GL YLH R+++H D+K +NILLD ++ K+ Sbjct: 679 DRLYGEASKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKV 738 Query: 381 ADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTGKK 554 ADFG S+ + +++ +RGT GYL PE+ +++ + D++S GV+++EI++G++ Sbjct: 739 ADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGRE 797
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 99.8 bits (247), Expect = 6e-21 Identities = 55/179 (30%), Positives = 102/179 (56%), Gaps = 7/179 (3%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL- 215 +EF + L ++H+N+V LGYC + Q++L + ++ NGSL Sbjct: 634 REFDNELNLLSAIQHENLVPLLGYCNE----------------YDQQILVYPFMSNGSLL 677 Query: 216 DKYITDTSRK--VQWRKCFQIIKGICQGLHYLHQ---RNILHLDLKPANILLDGNLVPKI 380 D+ + +++ + W I G +GL YLH R+++H D+K +NILLD ++ K+ Sbjct: 678 DRLYGEPAKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKV 737 Query: 381 ADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTGKK 554 ADFG S+ + +++ +RGT GYL PE+ +++ + D++S GV+++EI++G++ Sbjct: 738 ADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFGVVLLEIVSGRE 796
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 95.9 bits (237), Expect = 9e-20 Identities = 60/188 (31%), Positives = 97/188 (51%), Gaps = 13/188 (6%) Frame = +3 Query: 30 MYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNG 209 M ++ F VE L +H N+V F GYCA++ G + L + +LPNG Sbjct: 251 MVKQSFLTEVEQLSRFRHPNIVDFAGYCAES--------GLYC--------LVYGFLPNG 294 Query: 210 SLDKYI---TDTSRKVQWRKCFQIIKGICQGLHYLHQRN--ILHLDLKPANILLDGNLVP 374 SL+ + T + W + I+ G + + +LHQ + ++H D+K +N+LLD L+P Sbjct: 295 SLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMP 354 Query: 375 KIADFGVSRCFH-------EMQSRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVII 530 K+ DFG++R + + A T +RGTL YL E+ G + D +S GV+I Sbjct: 355 KLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVI 414 Query: 531 IEILTGKK 554 +E L G++ Sbjct: 415 LETLAGQR 422
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 95.9 bits (237), Expect = 9e-20 Identities = 54/182 (29%), Positives = 97/182 (53%), Gaps = 7/182 (3%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 E +F VE + M H+N++R G+C +RLL + Y+ NGS+ Sbjct: 328 ELQFQTEVEMISMAVHRNLLRLRGFCMTPT----------------ERLLVYPYMANGSV 371 Query: 216 DKYITDTSRK---VQWRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLVPK 377 + + + W K +I G +GL YLH I+H D+K ANILLD Sbjct: 372 ASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAV 431 Query: 378 IADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVIIIEILTGKK 554 + DFG+++ + + +T +RGT+G++APE+ + G+ + + D++ GV+++E++TG++ Sbjct: 432 VGDFGLAKLM-DYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQR 490 Query: 555 GY 560 + Sbjct: 491 AF 492
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 95.5 bits (236), Expect = 1e-19 Identities = 53/178 (29%), Positives = 94/178 (52%), Gaps = 6/178 (3%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 +E+ V L H N+V+ +GYC + + RLL +E++P GSL+ Sbjct: 118 QEWLAEVNYLGQFSHPNLVKLIGYCLEDE----------------HRLLVYEFMPRGSLE 161 Query: 219 KYITDTSRKVQ---WRKCFQIIKGICQGLHYLH--QRNILHLDLKPANILLDGNLVPKIA 383 ++ Q W ++ G +GL +LH + ++++ D K +NILLD K++ Sbjct: 162 NHLFRRGSYFQPLSWTLRLKVALGAAKGLAFLHNAETSVIYRDFKTSNILLDSEYNAKLS 221 Query: 384 DFGVSRCFHEMQSRAITVNIRGTLGYLAPEF-CNGEITYQLDIYSVGVIIIEILTGKK 554 DFG+++ ++ I GT GY APE+ G +T + D+YS GV+++E+L+G++ Sbjct: 222 DFGLAKDGPTGDKSHVSTRIMGTYGYAAPEYLATGHLTTKSDVYSYGVVLLEVLSGRR 279
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 94.4 bits (233), Expect = 3e-19 Identities = 66/212 (31%), Positives = 112/212 (52%), Gaps = 14/212 (6%) Frame = +3 Query: 18 SNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEY 197 S+ KEFH ++ L + H +++ LGYC D GS +RLL +E+ Sbjct: 539 SDVKKSSKEFHNELDLLSRLNHAHLLNLLGYCED--GS--------------ERLLVYEF 582 Query: 198 LPNGSLDKYI----TDTSRKVQWRKCFQIIKGICQGLHYLHQRN---ILHLDLKPANILL 356 + +GSL +++ + +++ W + I +G+ YLH ++H D+K +NIL+ Sbjct: 583 MAHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILI 642 Query: 357 DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVIII 533 D + ++ADFG+S ++ GTLGYL PE+ +T + D+YS GV+++ Sbjct: 643 DEDHNARVADFGLSILGPADSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLL 702 Query: 534 EILTGKKGYLAVD------NVVESWSNKLEKS 611 EIL+G+K A+D N+VE W+ L K+ Sbjct: 703 EILSGRK---AIDMQFEEGNIVE-WAVPLIKA 730
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 94.0 bits (232), Expect = 4e-19 Identities = 51/178 (28%), Positives = 96/178 (53%), Gaps = 6/178 (3%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 +E+ + L + H N+V+ +GYC + + RLL +E++ GSL+ Sbjct: 117 REWLAEINYLGQLDHPNLVKLIGYCLEEE----------------HRLLVYEFMTRGSLE 160 Query: 219 KYITDTS---RKVQWRKCFQIIKGICQGLHYLH--QRNILHLDLKPANILLDGNLVPKIA 383 ++ + + W ++ G +GL +LH Q +++ D K +NILLD N K++ Sbjct: 161 NHLFRRGTFYQPLSWNTRVRMALGAARGLAFLHNAQPQVIYRDFKASNILLDSNYNAKLS 220 Query: 384 DFGVSRCFHEMQSRAITVNIRGTLGYLAPEF-CNGEITYQLDIYSVGVIIIEILTGKK 554 DFG++R + ++ + GT GY APE+ G ++ + D+YS GV+++E+L+G++ Sbjct: 221 DFGLARDGPMGDNSHVSTRVMGTQGYAAPEYLATGHLSVKSDVYSFGVVLLELLSGRR 278
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 93.2 bits (230), Expect = 6e-19 Identities = 50/178 (28%), Positives = 96/178 (53%), Gaps = 6/178 (3%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 +E+ V L H+++V+ +GYC + + RLL +E++P GSL+ Sbjct: 117 QEWLAEVNYLGQFSHRHLVKLIGYCLEDE----------------HRLLVYEFMPRGSLE 160 Query: 219 KYITDTS---RKVQWRKCFQIIKGICQGLHYLH--QRNILHLDLKPANILLDGNLVPKIA 383 ++ + + W+ ++ G +GL +LH + +++ D K +NILLD K++ Sbjct: 161 NHLFRRGLYFQPLSWKLRLKVALGAAKGLAFLHSSETRVIYRDFKTSNILLDSEYNAKLS 220 Query: 384 DFGVSRCFHEMQSRAITVNIRGTLGYLAPEF-CNGEITYQLDIYSVGVIIIEILTGKK 554 DFG+++ ++ + GT GY APE+ G +T + D+YS GV+++E+L+G++ Sbjct: 221 DFGLAKDGPIGDKSHVSTRVMGTHGYAAPEYLATGHLTTKSDVYSFGVVLLELLSGRR 278
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 93.2 bits (230), Expect = 6e-19 Identities = 55/175 (31%), Positives = 94/175 (53%), Gaps = 5/175 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F ++ L ++H+++VR LGY +A+ LL +EY+PNGSL + Sbjct: 734 FTAEIQTLGRIRHRHIVRLLGY----------------VANKDTNLLLYEYMPNGSLGEL 777 Query: 225 ITDTSR-KVQWRKCFQIIKGICQGLHYLHQRN---ILHLDLKPANILLDGNLVPKIADFG 392 + + +QW ++ +GL YLH ILH D+K NILLD + +ADFG Sbjct: 778 LHGSKGGHLQWETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNNILLDSDFEAHVADFG 837 Query: 393 VSRCFHEMQSRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTGKK 554 +++ + + +I G+ GY+APE+ ++ + D+YS GV+++E++ GKK Sbjct: 838 LAKFLVDGAASECMSSIAGSYGYIAPEYAYTLKVDEKSDVYSFGVVLLELIAGKK 892
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 92.8 bits (229), Expect = 8e-19 Identities = 59/186 (31%), Positives = 93/186 (50%), Gaps = 13/186 (6%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 ++ F VE L +H N+V F GYCA NG + L + +LPNGSL Sbjct: 253 KQSFLTEVEQLSRFRHPNIVDFAGYCAQ--------NGFYC--------LVYGFLPNGSL 296 Query: 216 DKYI---TDTSRKVQWRKCFQIIKGICQGLHYLHQRN--ILHLDLKPANILLDGNLVPKI 380 + + T + W + I+ G + + +LHQ + ++H D+K +N+LLD L PK+ Sbjct: 297 EDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKL 356 Query: 381 ADFGVSRCFH-------EMQSRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIE 536 DFG++R + A T +RGTL YL E+ G + D +S GV+++E Sbjct: 357 GDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLE 416 Query: 537 ILTGKK 554 L G++ Sbjct: 417 TLAGQR 422
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 90.1 bits (222), Expect = 5e-18 Identities = 53/174 (30%), Positives = 94/174 (54%), Gaps = 6/174 (3%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R +E + V+H+N+++ +E + + L+ + Y+ NGSL + Sbjct: 860 REIETIGKVRHRNLIK-----------LEEF-----WLRKEYGLILYTYMENGSLHDILH 903 Query: 231 DTS--RKVQWRKCFQIIKGICQGLHYLH---QRNILHLDLKPANILLDGNLVPKIADFGV 395 +T+ + + W I G GL YLH I+H D+KP NILLD +L P I+DFG+ Sbjct: 904 ETNPPKPLDWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGI 963 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTGKK 554 ++ + + + ++GT+GY+APE + + + D+YS GV+++E++T KK Sbjct: 964 AKLLDQSATSIPSNTVQGTIGYMAPENAFTTVKSRESDVYSYGVVLLELITRKK 1017
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 87.0 bits (214), Expect = 4e-17 Identities = 58/179 (32%), Positives = 93/179 (51%), Gaps = 9/179 (5%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F VE L ++HK++VR +C + G +LL +EY+PNGSL Sbjct: 734 FAAEVETLGTIRHKSIVRL--WCCCSSGDC--------------KLLVYEYMPNGSLADV 777 Query: 225 ITDTSRK---VQWRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLVPKIAD 386 + + + W + +I +GL YLH I+H D+K +NILLD + K+AD Sbjct: 778 LHGDRKGGVVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVAD 837 Query: 387 FGVSRCFHEMQSRA--ITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTGKK 554 FG+++ S+ I G+ GY+APE+ + + DIYS GV+++E++TGK+ Sbjct: 838 FGIAKVGQMSGSKTPEAMSGIAGSCGYIAPEYVYTLRVNEKSDIYSFGVVLLELVTGKQ 896
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 85.5 bits (210), Expect = 1e-16 Identities = 56/179 (31%), Positives = 90/179 (50%), Gaps = 1/179 (0%) Frame = +3 Query: 57 VECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDT 236 ++ L +KH N++ F G C TQ + EY +G L + + Sbjct: 205 IKHLRKLKHPNIIAFKGVC--TQAPCY--------------CIIMEYCAHGQLYEVLR-A 247 Query: 237 SRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEM 416 RK+ R GI G++YLH I+H DLK N+L+ KI+DFG S+ E+ Sbjct: 248 GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK---EL 304 Query: 417 QSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYLAVDNVVESW 590 ++ ++ GT+ +LAPE E ++ ++DI+S GV++ E+LTG+ Y VD+ W Sbjct: 305 SDKSTKMSFAGTVAWLAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW 363
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 85.1 bits (209), Expect = 2e-16 Identities = 59/187 (31%), Positives = 95/187 (50%), Gaps = 5/187 (2%) Frame = +3 Query: 15 LSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCF- 191 LS T + E F + L +KH N+V F+G C +++ +C Sbjct: 1398 LSETQLLE--FRAEMAFLSELKHSNIVTFIGAC------------------IKKPNICIV 1437 Query: 192 -EYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRN--ILHLDLKPANILLDG 362 EY+ G+L + + K+ + +++ G G+ YLH N I+H D+KPANIL+D Sbjct: 1438 TEYMRMGNLRDVLKNPDIKITFANKLKLLYGAAMGIDYLHSSNPMIVHRDIKPANILVDE 1497 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEI 539 + KIADFG +R ++ T+ GT + APE GE + D++S GV++ E+ Sbjct: 1498 HFNVKIADFGFAR----IKEDNTTMTRCGTPCWTAPEVIRGEKYCEKADVFSFGVVMWEV 1553 Query: 540 LTGKKGY 560 LTGK+ + Sbjct: 1554 LTGKEPF 1560 Score = 83.6 bits (205), Expect = 5e-16 Identities = 61/197 (30%), Positives = 101/197 (51%), Gaps = 11/197 (5%) Frame = +3 Query: 3 AVXXLSNTHM---YEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQ 173 AV +S+ H+ E+ F V+ + ++H NVV F+ S + N VM Sbjct: 811 AVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMA------ASTKSPNMCIVM---- 860 Query: 174 QRLLCFEYLPNGSL-----DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLK 338 E++ GSL ++ I + ++ + +Q KG +H+LH I+H DLK Sbjct: 861 ------EFMSLGSLYDLLGNELIPEIPYALKIKMAYQASKG----MHFLHSSGIVHRDLK 910 Query: 339 PANILLDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG--EITYQL-DI 509 N+LLD K++DFG+++ E+ + NI GT+ ++APE N E+ Y L D+ Sbjct: 911 SLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIAPEILNDSTEVDYILADV 970 Query: 510 YSVGVIIIEILTGKKGY 560 YS G+I+ E+LT ++ Y Sbjct: 971 YSFGIILWELLTREQPY 987
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 84.7 bits (208), Expect = 2e-16 Identities = 55/179 (30%), Positives = 90/179 (50%), Gaps = 1/179 (0%) Frame = +3 Query: 57 VECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDT 236 ++ L +KH N++ F G C TQ + EY +G L + + Sbjct: 205 IKHLRKLKHPNIIAFKGVC--TQAPCY--------------CIIMEYCAHGQLYEVLR-A 247 Query: 237 SRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEM 416 RK+ R GI G++YLH I+H DLK N+L+ KI+DFG S+ E+ Sbjct: 248 GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK---EL 304 Query: 417 QSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYLAVDNVVESW 590 ++ ++ GT+ ++APE E ++ ++DI+S GV++ E+LTG+ Y VD+ W Sbjct: 305 SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW 363
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 83.6 bits (205), Expect = 5e-16 Identities = 42/128 (32%), Positives = 73/128 (57%), Gaps = 1/128 (0%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 + EY+ +L + I T + ++ +I+ CQ L++ HQ I+H D+KPANI++ Sbjct: 90 IVMEYVDGATL-RDIVHTDGPMPPQQAIEIVADACQALNFSHQNGIIHRDVKPANIMISA 148 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEI 539 K+ DFG++R + S T + GT YL+PE G+ + + D+YS+G ++ EI Sbjct: 149 TNAVKVMDFGIARAIADSTSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEI 208 Query: 540 LTGKKGYL 563 LTG+ ++ Sbjct: 209 LTGEPPFI 216
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 82.8 bits (203), Expect = 8e-16 Identities = 57/173 (32%), Positives = 82/173 (47%), Gaps = 1/173 (0%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 E + R VE ++H N++R GY D + L +Y P G L Sbjct: 182 EHQLRREVEIQSHLRHPNILRLYGY----------------FHDASRVYLILDYAPGGEL 225 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 + + +R R I K + + L Y H + ++H D+KP N+LL N KIADFG Sbjct: 226 FRELQKCTRFDDQRSALYI-KQLAEALLYCHSKKVIHRDIKPENLLLGSNGELKIADFGW 284 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTGK 551 S H SR T + GTL YL PE G + ++D++S+GV+ E L GK Sbjct: 285 S--VHAPSSRRTT--LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGK 333
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 82.4 bits (202), Expect = 1e-15 Identities = 57/173 (32%), Positives = 82/173 (47%), Gaps = 1/173 (0%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 E + R VE ++H N++R GY D + L +Y P G L Sbjct: 182 EHQLRREVEIQSHLRHPNILRLYGY----------------FHDASRVYLILDYAPGGEL 225 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 + + +R R I K + + L Y H + ++H D+KP N+LL N KIADFG Sbjct: 226 FRELQKCTRFDDQRSAMYI-KQLAEALLYCHSKKVIHRDIKPENLLLGSNGELKIADFGW 284 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ-LDIYSVGVIIIEILTGK 551 S H SR T + GTL YL PE G + + +D++S+GV+ E L GK Sbjct: 285 S--VHAPSSRRTT--LCGTLDYLPPEMIEGRMHDETVDLWSLGVLCYEFLVGK 333
>ST17B_MOUSE (Q8BG48) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 372 Score = 81.6 bits (200), Expect = 2e-15 Identities = 53/146 (36%), Positives = 82/146 (56%), Gaps = 6/146 (4%) Frame = +3 Query: 156 VMADVQQRLLCFEYLPNGSL-DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLD 332 V + + +L EY G + + + + + V ++IK I +G+HYLHQ NI+HLD Sbjct: 99 VYENATEIILVLEYAAGGEIFNLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLD 158 Query: 333 LKPANILLDGNLVP----KIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITY 497 LKP NILL ++ P KI DFG+SR ++ + + I GT YLAPE N + IT Sbjct: 159 LKPQNILL-SSIYPLGDIKIVDFGMSR---KIGNASELREIMGTPEYLAPEILNYDPITT 214 Query: 498 QLDIYSVGVIIIEILTGKKGYLAVDN 575 D++++G+I +LT ++ DN Sbjct: 215 ATDMWNIGIIAYMLLTHTSPFVGEDN 240
>ST17B_RAT (Q91XS8) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 371 Score = 81.3 bits (199), Expect = 2e-15 Identities = 52/138 (37%), Positives = 79/138 (57%), Gaps = 6/138 (4%) Frame = +3 Query: 180 LLCFEYLPNGSL-DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL 356 +L EY G + + + + + V ++IK I +G+HYLHQ NI+HLDLKP NILL Sbjct: 107 ILVLEYAAGGEIFNLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLKPQNILL 166 Query: 357 DGNLVP----KIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVG 521 ++ P KI DFG+SR ++ + + I GT YLAPE N + IT D++++G Sbjct: 167 -SSIYPLGDIKIVDFGMSR---KIGNASELREIMGTPEYLAPEILNYDPITTATDMWNIG 222 Query: 522 VIIIEILTGKKGYLAVDN 575 +I +LT ++ DN Sbjct: 223 IIAYMLLTHTSPFVGEDN 240
>MK14C_DROME (P83100) Putative mitogen-activated protein kinase 14C (EC| 2.7.11.24) (MAP kinase p38c) Length = 356 Score = 81.3 bits (199), Expect = 2e-15 Identities = 53/174 (30%), Positives = 89/174 (51%), Gaps = 3/174 (1%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K +R + L + H+NV+ L +M + Q++ +L + L Sbjct: 62 KGTYREIRLLKHMNHRNVISLLNVFHPPAHNMMEF----------QQVYLVTHLMDADLH 111 Query: 219 KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVS 398 +Y S+++ ++ I+ I +GL Y+H ++H DLKP NI ++GN +I DFG+S Sbjct: 112 RY--SRSKRMSDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLS 169 Query: 399 R-CFHEMQSRAITVNIRGTLGYLAPE--FCNGEITYQLDIYSVGVIIIEILTGK 551 R C +M GT+ YLAPE F G+ T +D++SVG I+ E++T + Sbjct: 170 RMCADKMTDHV------GTMWYLAPEIIFLRGQYTKAIDVWSVGCILAELITDR 217
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 81.3 bits (199), Expect = 2e-15 Identities = 57/197 (28%), Positives = 100/197 (50%), Gaps = 10/197 (5%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 ++ + ++ L ++H N++ GY GK L ++ + GSL+ Sbjct: 257 QQSYNELKYLNSIRHDNILALYGYSIK--------GGK--------PCLVYQLMKGGSLE 300 Query: 219 KYITDTSRK-----VQWRKCFQIIKGICQGLHYLHQRN---ILHLDLKPANILLDGNLVP 374 + + + W++ F I G +G+++LH ++H D+KPANILLD L P Sbjct: 301 ARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQP 360 Query: 375 KIADFGVSRCFHEMQSRAITVN-IRGTLGYLAPEFCN-GEITYQLDIYSVGVIIIEILTG 548 KI DFG+ R + + VN + GT YL PEF N +++ +D+YS G++++E+ TG Sbjct: 361 KIGDFGLVREGPKSLDAVVEVNKVFGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTG 420 Query: 549 KKGYLAVDNVVESWSNK 599 ++ D V E+ + K Sbjct: 421 RQ---VTDRVPENETKK 434
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 81.3 bits (199), Expect = 2e-15 Identities = 52/181 (28%), Positives = 84/181 (46%), Gaps = 4/181 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY K +A V Q + SL K+ Sbjct: 123 FRNEVAVLRKTRHVNILLFMGYMT-----------KDNLAIVTQ------WCEGSSLYKH 165 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K Q + I + QG+ YLH +NI+H D+K NI L G L KI DFG++ Sbjct: 166 LHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHGGLTVKIGDFGLATV 225 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 G++ ++APE + ++Q D+YS G+++ E++TG+ Y ++ Sbjct: 226 KSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELPYSHIN 285 Query: 573 N 575 N Sbjct: 286 N 286
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 80.9 bits (198), Expect = 3e-15 Identities = 56/170 (32%), Positives = 87/170 (51%), Gaps = 8/170 (4%) Frame = +3 Query: 75 VKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDTSRKVQW 254 +K +++V G C G + E++ NGSL+K ++ S + W Sbjct: 78 IKFQHIVSIYGVCKQPLG------------------IVMEFMANGSLEKVLSTHS--LCW 117 Query: 255 RKCFQIIKGICQGLHYLHQRN--ILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSRA 428 + F+II +++LH +LHLDLKP NILLD N+ KI+DFG+S+ + E +R Sbjct: 118 KLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSK-WMEQSTRM 176 Query: 429 ITVN---IRGTLGYLAPEF---CNGEITYQLDIYSVGVIIIEILTGKKGY 560 + +RG L Y+ PE N + D+YS ++I E+LT KK Y Sbjct: 177 QYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPY 226
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 80.1 bits (196), Expect = 5e-15 Identities = 50/139 (35%), Positives = 79/139 (56%), Gaps = 6/139 (4%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLH--QRNILHLDLKPANILL 356 L EY+ GSL+K + S + W F+II G+++LH +LHLDLKPANILL Sbjct: 94 LVMEYMETGSLEKLLA--SEPLPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILL 151 Query: 357 DGNLVPKIADFGVSRCFHEMQSRAITVN-IRGTLGYLAPEFCNGE---ITYQLDIYSVGV 524 D + KI+DFG+++C S ++++ + GT+ YL PE + + D+YS + Sbjct: 152 DAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAI 211 Query: 525 IIIEILTGKKGYLAVDNVV 581 +I +LT KK + N++ Sbjct: 212 VIWGVLTQKKPFADEKNIL 230
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 80.1 bits (196), Expect = 5e-15 Identities = 53/172 (30%), Positives = 84/172 (48%), Gaps = 1/172 (0%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 EK+F R VE ++H N+ + GY D ++ L EYL NG L Sbjct: 151 EKQFRREVEIQSSLRHPNLTQLYGY----------------FHDEKRVYLLMEYLVNGEL 194 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 K++ S + + + + L Y+H+RNILH D+KP NI++ N K+ DFG Sbjct: 195 YKHLKGRSHFNDVVASYYVYQ-MADALDYMHERNILHRDIKPENIIIGFNNTIKLTDFGW 253 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTG 548 S + R + GT+ YL+PE E ++D++++GV+ E+L G Sbjct: 254 SVITPKGSKRK---TLCGTVDYLSPELIRSREYNEKVDVWALGVLTYELLVG 302
>ST17B_HUMAN (O94768) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 372 Score = 79.7 bits (195), Expect = 7e-15 Identities = 54/147 (36%), Positives = 80/147 (54%), Gaps = 7/147 (4%) Frame = +3 Query: 156 VMADVQQRLLCFEYLPNGSLDKY-ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLD 332 V + + +L EY G + + + + V ++IK I +G++YLHQ NI+HLD Sbjct: 99 VYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLD 158 Query: 333 LKPANILLDGNLVP----KIADFGVSRCF-HEMQSRAITVNIRGTLGYLAPEFCNGE-IT 494 LKP NILL ++ P KI DFG+SR H + R I GT YLAPE N + IT Sbjct: 159 LKPQNILL-SSIYPLGDIKIVDFGMSRKIGHACELR----EIMGTPEYLAPEILNYDPIT 213 Query: 495 YQLDIYSVGVIIIEILTGKKGYLAVDN 575 D++++G+I +LT ++ DN Sbjct: 214 TATDMWNIGIIAYMLLTHTSPFVGEDN 240
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 79.7 bits (195), Expect = 7e-15 Identities = 52/181 (28%), Positives = 83/181 (45%), Gaps = 4/181 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY K +A V Q + SL K+ Sbjct: 390 FRNEVAVLRKTRHVNILLFMGYMT-----------KDNLAIVTQ------WCEGSSLYKH 432 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K Q + I + QG+ YLH +NI+H D+K NI L L KI DFG++ Sbjct: 433 LHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV 492 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 G++ ++APE N ++Q D+YS G+++ E++TG+ Y ++ Sbjct: 493 KSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHIN 552 Query: 573 N 575 N Sbjct: 553 N 553
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 79.7 bits (195), Expect = 7e-15 Identities = 52/181 (28%), Positives = 83/181 (45%), Gaps = 4/181 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY K +A V Q + SL K+ Sbjct: 390 FRNEVAVLRKTRHVNILLFMGYMT-----------KDNLAIVTQ------WCEGSSLYKH 432 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K Q + I + QG+ YLH +NI+H D+K NI L L KI DFG++ Sbjct: 433 LHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV 492 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 G++ ++APE N ++Q D+YS G+++ E++TG+ Y ++ Sbjct: 493 KSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHIN 552 Query: 573 N 575 N Sbjct: 553 N 553
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 79.7 bits (195), Expect = 7e-15 Identities = 49/177 (27%), Positives = 86/177 (48%), Gaps = 2/177 (1%) Frame = +3 Query: 21 NTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYL 200 +T + ++F R +E L ++H N+V++ G C S R N + +M EYL Sbjct: 887 STEEHLRDFEREIEILKSLQHDNIVKYKGVCY----SAGRRNLRLIM----------EYL 932 Query: 201 PNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKI 380 P GSL Y+ ++ +K Q IC+G+ YL + +H DL NIL++ KI Sbjct: 933 PYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKI 992 Query: 381 ADFGVSRCF-HEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILT 545 DFG+++ + + + + + APE + + D++S GV++ E+ T Sbjct: 993 GDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFT 1049 Score = 37.7 bits (86), Expect = 0.030 Identities = 22/108 (20%), Positives = 45/108 (41%) Frame = +3 Query: 33 YEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGS 212 Y + F + + HK++V G C + + +L E++ GS Sbjct: 590 YSESFFEAASMMSQLSHKHLVLNYGVCVCGE----------------ENILVQEFVKFGS 633 Query: 213 LDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL 356 LD Y+ + + K + +H+L +++++H ++ NILL Sbjct: 634 LDTYLKKNKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILL 681
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 79.3 bits (194), Expect = 9e-15 Identities = 48/174 (27%), Positives = 86/174 (49%), Gaps = 1/174 (0%) Frame = +3 Query: 33 YEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGS 212 + K+F R + + H N+V Y +G + + EY+ + Sbjct: 51 FVKKFKRESQAAASLSHPNIVGI--YDVGQEGDIY--------------YIVMEYVKGRT 94 Query: 213 LDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFG 392 L + I + ++ ++ +I +C+ L + H+ I+H D+KP NIL+ V K+ DFG Sbjct: 95 LKELIRENGGPLEVKRAVEIASQVCRALDHAHKNKIIHRDIKPQNILVTDEDVVKVTDFG 154 Query: 393 VSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEIT-YQLDIYSVGVIIIEILTGK 551 ++R + + T ++ GT Y +PE G I + DIYS+G+++ E+LTGK Sbjct: 155 IARAANG-ATITYTGDVIGTAYYFSPEQAKGSIVDERTDIYSLGIVLFEMLTGK 207
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 79.0 bits (193), Expect = 1e-14 Identities = 54/179 (30%), Positives = 89/179 (49%), Gaps = 1/179 (0%) Frame = +3 Query: 57 VECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDT 236 ++ L +KH N++ F G C TQ + E+ G L + + Sbjct: 162 IKHLRKLKHPNIITFKGVC--TQAPCY--------------CILMEFCAQGQLYEVLR-A 204 Query: 237 SRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEM 416 R V GI G++YLH I+H DLK N+L+ + V KI+DFG S+ E+ Sbjct: 205 GRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSK---EL 261 Query: 417 QSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYLAVDNVVESW 590 ++ ++ GT+ ++APE E ++ ++DI+S GV++ E+LTG+ Y VD+ W Sbjct: 262 SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW 320
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 79.0 bits (193), Expect = 1e-14 Identities = 54/179 (30%), Positives = 89/179 (49%), Gaps = 1/179 (0%) Frame = +3 Query: 57 VECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDT 236 ++ L +KH N++ F G C TQ + E+ G L + + Sbjct: 195 IKHLRKLKHPNIITFKGVC--TQAPCY--------------CILMEFCAQGQLYEVLR-A 237 Query: 237 SRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEM 416 R V GI G++YLH I+H DLK N+L+ + V KI+DFG S+ E+ Sbjct: 238 GRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSK---EL 294 Query: 417 QSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYLAVDNVVESW 590 ++ ++ GT+ ++APE E ++ ++DI+S GV++ E+LTG+ Y VD+ W Sbjct: 295 SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW 353
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 79.0 bits (193), Expect = 1e-14 Identities = 54/179 (30%), Positives = 89/179 (49%), Gaps = 1/179 (0%) Frame = +3 Query: 57 VECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDT 236 ++ L +KH N++ F G C TQ + E+ G L + + Sbjct: 195 IKHLRKLKHPNIITFKGVC--TQAPCY--------------CILMEFCAQGQLYEVLR-A 237 Query: 237 SRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEM 416 R V GI G++YLH I+H DLK N+L+ + V KI+DFG S+ E+ Sbjct: 238 GRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSK---EL 294 Query: 417 QSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYLAVDNVVESW 590 ++ ++ GT+ ++APE E ++ ++DI+S GV++ E+LTG+ Y VD+ W Sbjct: 295 SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW 353
>NRKA_TRYBB (Q08942) Putative serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 431 Score = 79.0 bits (193), Expect = 1e-14 Identities = 54/193 (27%), Positives = 92/193 (47%), Gaps = 6/193 (3%) Frame = +3 Query: 6 VXXLSNTHMYEKEFHRX-VECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRL 182 V LS +K + + ++CL H N++R Y D + + + L Sbjct: 50 VMDLSKMSQRDKRYAQSEIKCLANCNHPNIIR---YIEDHEEN-------------DRLL 93 Query: 183 LCFEYLPNGSLDKYI----TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANI 350 + E+ +G+LD+ I + +R Q + + +C L Y+H +LH D+K AN+ Sbjct: 94 IVMEFADSGNLDEQIKLRGSGDARYFQEHEALFLFLQLCLALDYIHSHKMLHRDIKSANV 153 Query: 351 LLDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVI 527 LL + K+ DFG S + + S + GT YLAPE N + + D++S+GV+ Sbjct: 154 LLTSTGLVKLGDFGFSHQYEDTVSGVVASTFCGTPYYLAPELWNNKRYNKKADVWSLGVL 213 Query: 528 IIEILTGKKGYLA 566 + EI+ KK + A Sbjct: 214 LYEIMGMKKPFSA 226
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 79.0 bits (193), Expect = 1e-14 Identities = 50/177 (28%), Positives = 85/177 (48%), Gaps = 2/177 (1%) Frame = +3 Query: 21 NTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYL 200 +T + ++F R +E L ++H N+V++ G C S R N K +M EYL Sbjct: 887 STEEHLRDFEREIEILKSLQHDNIVKYKGVCY----SAGRRNLKLIM----------EYL 932 Query: 201 PNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKI 380 P GSL Y+ ++ K Q IC+G+ YL + +H DL NIL++ KI Sbjct: 933 PYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKI 992 Query: 381 ADFGVSRCF-HEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILT 545 DFG+++ + + + + + APE + + D++S GV++ E+ T Sbjct: 993 GDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFT 1049 Score = 37.0 bits (84), Expect = 0.051 Identities = 24/108 (22%), Positives = 45/108 (41%) Frame = +3 Query: 33 YEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGS 212 Y + F + + HK++V G C V D + +L E++ GS Sbjct: 590 YSESFFEAASMMSKLSHKHLVLNYGVC--------------VCGD--ENILVQEFVKFGS 633 Query: 213 LDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL 356 LD Y+ + ++ K + +H+L + ++H ++ NILL Sbjct: 634 LDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILL 681
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 78.6 bits (192), Expect = 2e-14 Identities = 48/177 (27%), Positives = 86/177 (48%), Gaps = 2/177 (1%) Frame = +3 Query: 21 NTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYL 200 +T + ++F R +E L ++H N+V++ G C S R N + +M EYL Sbjct: 887 STEEHLRDFEREIEILKSLQHDNIVKYKGVCY----SAGRRNLRLIM----------EYL 932 Query: 201 PNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKI 380 P GSL Y+ ++ +K Q IC+G+ YL + +H DL NIL++ KI Sbjct: 933 PYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKI 992 Query: 381 ADFGVSRCF-HEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILT 545 DFG+++ + + + + + AP+ + + D++S GV++ E+ T Sbjct: 993 GDFGLTKVLPQDKEYYKVKEPGESPIFWYAPQSLTESKFSVASDVWSFGVVLYELFT 1049 Score = 37.7 bits (86), Expect = 0.030 Identities = 22/108 (20%), Positives = 45/108 (41%) Frame = +3 Query: 33 YEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGS 212 Y + F + + HK++V G C + + +L E++ GS Sbjct: 590 YSESFFEAASMMSQLSHKHLVLNYGVCVCGE----------------ENILVQEFVKFGS 633 Query: 213 LDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL 356 LD Y+ + + K + +H+L +++++H ++ NILL Sbjct: 634 LDTYLKKNKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILL 681
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 78.2 bits (191), Expect = 2e-14 Identities = 44/102 (43%), Positives = 62/102 (60%), Gaps = 1/102 (0%) Frame = +3 Query: 258 KCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSRAITV 437 KC + I GL +LH ++ILHLDLKPANIL+ V KI+DFG S+ +++ R Sbjct: 172 KCLKYSLDIVNGLLFLHSQSILHLDLKPANILISEKDVCKISDFGCSQKLQDLRCRPSLH 231 Query: 438 NIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTGKKGY 560 +I GT + APE GEI T + DIYS G+ + ++ T + Y Sbjct: 232 HIGGTYTHQAPELLKGEIATPKADIYSFGITLWQMTTREVPY 273
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 78.2 bits (191), Expect = 2e-14 Identities = 54/173 (31%), Positives = 84/173 (48%), Gaps = 7/173 (4%) Frame = +3 Query: 75 VKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDTSRKVQW 254 +K +++V G C G + E++ +GSL+K T + + W Sbjct: 90 IKFQHIVSIYGVCKQPLG------------------IVMEFMASGSLEK--TLPTHSLCW 129 Query: 255 RKCFQIIKGICQGLHYLHQRN--ILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSRA 428 +II +++LH +LHLDLKP NILLD N+ KI+DFG+S+ + + Sbjct: 130 PLKLRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDNNMHVKISDFGLSKWMEQSTQKQ 189 Query: 429 ITVN--IRGTLGYLAPEFC---NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 +RGTL Y+ PE N + D+YS ++I EILT KK Y ++ Sbjct: 190 YIERSALRGTLSYIPPEMFLENNKAPGPEYDVYSFAIVIWEILTQKKPYAGLN 242
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 78.2 bits (191), Expect = 2e-14 Identities = 51/181 (28%), Positives = 83/181 (45%), Gaps = 4/181 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY K +A V Q + SL K+ Sbjct: 390 FRNEVAVLRKTRHVNILLFMGYMT-----------KDNLAIVTQ------WCEGSSLYKH 432 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K Q + I + QG+ YLH +NI+H D+K NI L L KI DFG++ Sbjct: 433 LHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV 492 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 G++ ++APE + ++Q D+YS G+++ E++TG+ Y ++ Sbjct: 493 KSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELPYSHIN 552 Query: 573 N 575 N Sbjct: 553 N 553
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)| Length = 508 Score = 78.2 bits (191), Expect = 2e-14 Identities = 53/186 (28%), Positives = 92/186 (49%), Gaps = 4/186 (2%) Frame = +3 Query: 6 VXXLSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLL 185 + L+ Y+K+ R ++ + + +VR+ G D + S + Sbjct: 252 INTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENS--------------SIYI 297 Query: 186 CFEYLPNGSLD---KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL 356 EY+ SLD K + + ++ + +I + + +GL YLH++ ++H D+KP NILL Sbjct: 298 AMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILL 357 Query: 357 DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIII 533 + N K+ DFGVS + S A T GT Y+APE G+ + D++S+G+ I+ Sbjct: 358 NENGQVKLCDFGVSG--EAVNSLATT--FTGTSFYMAPERIQGQPYSVTSDVWSLGLTIL 413 Query: 534 EILTGK 551 E+ GK Sbjct: 414 EVANGK 419
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 77.8 bits (190), Expect = 3e-14 Identities = 47/159 (29%), Positives = 86/159 (54%), Gaps = 2/159 (1%) Frame = +3 Query: 147 GKFVMADVQQRLLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILH 326 G+ + +V + EY+ +GS + + + RK+ + ++ GI Q L Y H+ I+H Sbjct: 78 GEDYIDNVSIPYIVMEYV-DGSTLRELLHSGRKLLPERTLEMTIGILQALEYSHRAGIVH 136 Query: 327 LDLKPANILLDGNLVPKIADFGVSRCFHEM-QSRAITVNIRGTLGYLAPEFCNGE-ITYQ 500 D+KPAN++L N K+ DFG++R + + T + GT YL+PE GE + + Sbjct: 137 RDIKPANVMLTRNGQVKVMDFGIARAMGDSGMTMTQTAAVIGTAQYLSPEQAKGEQVDAR 196 Query: 501 LDIYSVGVIIIEILTGKKGYLAVDNVVESWSNKLEKSQS 617 D+YS G ++ E+LT + ++ V ++ + E+ Q+ Sbjct: 197 SDLYSTGCLLYELLTVRPPFVGDSPVAVAYQHVREEPQA 235
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 77.8 bits (190), Expect = 3e-14 Identities = 58/189 (30%), Positives = 101/189 (53%), Gaps = 2/189 (1%) Frame = +3 Query: 57 VECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDT 236 V L + H N+V++LG+ E N + L EY+ GS+ I Sbjct: 1229 VSTLKDLDHLNIVQYLGF--------ENKNNIYS--------LFLEYVAGGSVGSLIRMY 1272 Query: 237 SRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEM 416 R + + + +GL YLH + ILH D+K N+LLD + + KI+DFG+SR ++ Sbjct: 1273 GRFDE-PLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDI 1331 Query: 417 QSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTGKKGYLAVDNVVESW 590 S + + +RGT+ ++APE + + Y ++DI+S+G I++E+ GK+ + ++ V + Sbjct: 1332 YSNS-DMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMF 1390 Query: 591 SNKLEKSQS 617 K+ KS+S Sbjct: 1391 --KIGKSKS 1397
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 77.8 bits (190), Expect = 3e-14 Identities = 55/172 (31%), Positives = 82/172 (47%), Gaps = 1/172 (0%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 E + R VE ++H N++R GY D + L EY P G++ Sbjct: 166 EHQLRREVEIQSHLRHPNILRLYGY----------------FHDATRVYLILEYAPLGTV 209 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 + + S+ + R I + + L Y H + ++H D+KP N+LL N KIADFG Sbjct: 210 YRELQKLSKFDEQRTATYITE-LANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGW 268 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTG 548 S H SR T + GTL YL PE G + ++D++S+GV+ E L G Sbjct: 269 S--VHAPSSRRTT--MCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVG 316
>MOS_MSVTS (P10421) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 342 Score = 77.8 bits (190), Expect = 3e-14 Identities = 43/102 (42%), Positives = 62/102 (60%), Gaps = 1/102 (0%) Frame = +3 Query: 258 KCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSRAITV 437 KC + + GL +LH ++ILHLDLKPANIL+ V KI+DFG S+ +++ R Sbjct: 174 KCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQSPH 233 Query: 438 NIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTGKKGY 560 +I GT + APE GEI T + DIYS G+ + ++ T + Y Sbjct: 234 HIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPY 275
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 77.8 bits (190), Expect = 3e-14 Identities = 41/125 (32%), Positives = 71/125 (56%), Gaps = 2/125 (1%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 + EY+ +L + I T + ++ ++I CQ L++ HQ I+H D+KPANI++ Sbjct: 90 IVMEYVDGVTL-RDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISA 148 Query: 363 NLVPKIADFGVSRCFHEM-QSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIE 536 K+ DFG++R + S T + GT YL+PE G+ + + D+YS+G ++ E Sbjct: 149 TNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYE 208 Query: 537 ILTGK 551 +LTG+ Sbjct: 209 VLTGE 213
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 77.8 bits (190), Expect = 3e-14 Identities = 41/125 (32%), Positives = 71/125 (56%), Gaps = 2/125 (1%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 + EY+ +L + I T + ++ ++I CQ L++ HQ I+H D+KPANI++ Sbjct: 90 IVMEYVDGVTL-RDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISA 148 Query: 363 NLVPKIADFGVSRCFHEM-QSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIE 536 K+ DFG++R + S T + GT YL+PE G+ + + D+YS+G ++ E Sbjct: 149 TNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYE 208 Query: 537 ILTGK 551 +LTG+ Sbjct: 209 VLTGE 213
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 77.8 bits (190), Expect = 3e-14 Identities = 56/172 (32%), Positives = 84/172 (48%), Gaps = 1/172 (0%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 EK+F R VE ++H NV+R G+ D + L EY+ +G L Sbjct: 141 EKQFRREVEIQSNLRHTNVLRLFGH----------------FHDKDRVYLILEYVVHGEL 184 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 K + + R + I + + + L YLH +NI+H D+KP NILL N KI+DFG Sbjct: 185 YKLLRNQKRFTESTASSYIYQ-MSEALLYLHGKNIIHRDIKPENILLHFNDTIKISDFGW 243 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTG 548 S H +R T + GT+ YL PE +D++S+G+++ E L G Sbjct: 244 S--VHAPSNRRST--LCGTMDYLPPEIVQSRPYDKNVDVWSLGILMYEFLCG 291
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 77.4 bits (189), Expect = 3e-14 Identities = 56/178 (31%), Positives = 84/178 (47%), Gaps = 1/178 (0%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 E + R VE ++H N++R GY D + L EY P G++ Sbjct: 175 EHQLRREVEIQSHLRHPNILRLYGY----------------FHDATRVYLILEYAPLGTV 218 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 + + S+ + R I + + L Y H + ++H D+KP N+LL KIADFG Sbjct: 219 YRELQKLSKFDEQRTATYITE-LANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGW 277 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTGKKGYLA 566 S H SR T + GTL YL PE G + ++D++S+GV+ E L GK + A Sbjct: 278 S--VHAPSSRRTT--LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEA 331
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 77.0 bits (188), Expect = 4e-14 Identities = 54/169 (31%), Positives = 83/169 (49%), Gaps = 1/169 (0%) Frame = +3 Query: 57 VECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDT 236 + L + H N+V++ G+ + S E Y + EY NGSL + I+ + Sbjct: 71 ISLLKNLNHNNIVKYHGFI---RKSYELY-------------ILLEYCANGSLRRLISRS 114 Query: 237 SRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEM 416 S + + + GL YLH ++H D+K ANILL + K+ADFGVS + Sbjct: 115 STGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTI---V 171 Query: 417 QSRAITVNIRGTLGYLAPEFCNGEITYQL-DIYSVGVIIIEILTGKKGY 560 S A+T + GTL ++APE L DI+S+G ++E+LT Y Sbjct: 172 NSSALT--LAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPY 218
>MOS_MSVMO (P00538) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 77.0 bits (188), Expect = 4e-14 Identities = 57/173 (32%), Positives = 87/173 (50%), Gaps = 11/173 (6%) Frame = +3 Query: 75 VKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDTSR---- 242 ++H N+VR + T G +M E+ N +L + I D +R Sbjct: 146 LRHDNIVRVVAASTRTPEDSNSL-GTIIM----------EFGGNVTLHQVIYDATRSPEP 194 Query: 243 -----KVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCF 407 ++ KC + + GL +LH ++ILHLDLKPANIL+ V KI+DFG S+ Sbjct: 195 LSCRKQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKL 254 Query: 408 HEMQSR-AITVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTGKKGY 560 +++ R A +I GT + APE GEI T + DIYS G+ + ++ T + Y Sbjct: 255 QDLRGRQASPPHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPY 307
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 77.0 bits (188), Expect = 4e-14 Identities = 55/178 (30%), Positives = 93/178 (52%), Gaps = 6/178 (3%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K+ R V+ ++ ++H+NV+ LG + + V L ++ NGSL Sbjct: 56 KKISREVKAMVNLRHENVLLLLGVTENLEWDY-----------VYGPALVTGFMENGSLS 104 Query: 219 KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRN--ILHLDLKPANILLDGNLVPKIADFG 392 + + + W ++++ + G+ YLH N +LH DLKP+N+LLD L K+ADFG Sbjct: 105 GLLQPSCPR-PWPLLCRLLEEVVLGMCYLHSLNPSLLHRDLKPSNVLLDLELHAKLADFG 163 Query: 393 VSRCFHEMQ--SRAITVNIRGTLGYLAPEFC--NGEITYQLDIYSVGVIIIEILTGKK 554 +S Q S + + + GTL YLAPE +G+ + D+YS GV++ +L G++ Sbjct: 164 LSTFQGGSQSGSGSGSRDSGGTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLAGRE 221
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 76.6 bits (187), Expect = 6e-14 Identities = 50/176 (28%), Positives = 80/176 (45%), Gaps = 4/176 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY K +A V Q + SL + Sbjct: 381 FRNEVAVLRKTRHVNILLFMGYMT-----------KDNLAIVTQ------WCEGSSLYYH 423 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K Q + I + QG+ YLH +NI+H D+K NI L L KI DFG++ Sbjct: 424 LHVLDTKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV 483 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGY 560 + G++ ++APE N ++Q D+YS G+++ E++TG+ Y Sbjct: 484 KTRWSGSQQVEQLTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPY 539
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 76.6 bits (187), Expect = 6e-14 Identities = 51/172 (29%), Positives = 84/172 (48%), Gaps = 1/172 (0%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 +K+F R VE KHKN+ + G+ D ++ L EY+ G L Sbjct: 142 QKQFRREVEIQGSFKHKNLTQLYGF----------------FYDEKRVYLLMEYVYYGEL 185 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 K++ + + + + + + L Y+H +NILH D+KP NIL+ N K+ DFG Sbjct: 186 YKFLKNNGPLNETLASYFVYQ-MANALDYMHSKNILHRDIKPENILIGFNNTIKLTDFGW 244 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTG 548 S + Q R + GT+ YL+PE E ++D++++GV+ E+L G Sbjct: 245 SVYNEDGQKRK---TLCGTIDYLSPELIKSREYNNKVDVWALGVLTYELLVG 293
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 76.3 bits (186), Expect = 8e-14 Identities = 50/181 (27%), Positives = 82/181 (45%), Gaps = 4/181 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY K +A V Q + SL K+ Sbjct: 390 FRNEVAVLRKTRHVNILLFMGYMT-----------KDNLAIVTQ------WCEGSSLYKH 432 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K Q + I + QG+ YLH +NI+H D+K NI L L KI DFG++ Sbjct: 433 LHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV 492 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 G++ ++APE + ++Q D+YS G+++ E++ G+ Y ++ Sbjct: 493 KSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHIN 552 Query: 573 N 575 N Sbjct: 553 N 553
>PKNB_BIFLO (Q8G6P9) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 690 Score = 76.3 bits (186), Expect = 8e-14 Identities = 52/185 (28%), Positives = 87/185 (47%), Gaps = 6/185 (3%) Frame = +3 Query: 15 LSNTHMYEKEFHRXVECLMMVKHKNVVRFLG----YCADTQGSMERYNGKFVMADVQQRL 182 L+N ++ F R + + + N+V + G ER VM V+ + Sbjct: 49 LANDDIFLARFRREAHAVAQMNNPNIVNIYDSGEELVSSESGDAERLP-YIVMEYVKGQT 107 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 L NG+L + R C Q++ G+ L Y H+ I+H D+KP NI++ Sbjct: 108 LRDIIKVNGALSQ-----------RDCEQVMLGVLNALDYSHRMGIIHRDIKPGNIMISE 156 Query: 363 NLVPKIADFGVSRCFHEMQSRAI-TVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIE 536 V K+ DFG++R + + + + GT YL+PE GE + + D+YS G ++ E Sbjct: 157 QGVVKVMDFGIARALDDSAATMTQSQGVVGTAQYLSPEQARGETVDMRSDLYSAGCVLYE 216 Query: 537 ILTGK 551 +LTG+ Sbjct: 217 MLTGR 221
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 76.3 bits (186), Expect = 8e-14 Identities = 47/183 (25%), Positives = 86/183 (46%), Gaps = 2/183 (1%) Frame = +3 Query: 3 AVXXLSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRL 182 A L ++ ++F + + ++H+ +V LG C + Q L Sbjct: 246 AAKMLQSSKAEREKFVLEAKIMHKLRHRKIVELLGVCTEPQD--------------MPML 291 Query: 183 LCFEYLPNGSLDKYI-TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD 359 + EY+ NGSL +Y+ T +K + ++ I +G+ YL ++H DL+ NIL+ Sbjct: 292 IIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEISEGMAYLESEKVVHRDLRADNILVA 351 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIE 536 +L K+ADFG++ +R + APE ++ T + D++S G+++ E Sbjct: 352 NDLTRKVADFGLTELTDGSLGDQEKKTLRFPYKWTAPEAAKSKVFTSKSDVWSYGIVMFE 411 Query: 537 ILT 545 ILT Sbjct: 412 ILT 414
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 76.3 bits (186), Expect = 8e-14 Identities = 50/181 (27%), Positives = 82/181 (45%), Gaps = 4/181 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY K +A V Q + SL K+ Sbjct: 65 FRNEVAVLRKTRHVNILLFMGYMT-----------KDNLAIVTQ------WCEGSSLYKH 107 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K Q + I + QG+ YLH +NI+H D+K NI L L KI DFG++ Sbjct: 108 LHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV 167 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 G++ ++APE + ++Q D+YS G+++ E++ G+ Y ++ Sbjct: 168 KSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHIN 227 Query: 573 N 575 N Sbjct: 228 N 228
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 76.3 bits (186), Expect = 8e-14 Identities = 47/182 (25%), Positives = 90/182 (49%), Gaps = 10/182 (5%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K F +E L++ +H +++ Y +T+ + L + Y+ NG+L Sbjct: 220 KRFLSELEVLLLFRHPHILELAAYFTETE----------------KLCLVYPYMSNGTLF 263 Query: 219 KYI--TDTSRKVQWRKCFQIIKGICQGLHYLHQRN---ILHLDLKPANILLDGNLVPKIA 383 + T+ + + W ++ GI + + YLH ++ ++ ANILLD L PK+ Sbjct: 264 DRLQCTNGTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLT 323 Query: 384 DFGVSRCFHEMQSRAITVNIRG----TLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTG 548 DF + ++ ++ T+N+ G L Y+ E+ G ++ + D+YS G++I+E+LTG Sbjct: 324 DFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTG 383 Query: 549 KK 554 K Sbjct: 384 CK 385
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 75.9 bits (185), Expect = 1e-13 Identities = 55/173 (31%), Positives = 82/173 (47%), Gaps = 2/173 (1%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 E + R +E ++H N++R Y D ++ L EY P G L Sbjct: 85 EHQLRREIEIQAHLQHPNILRLYNY----------------FHDARRVYLILEYAPRGEL 128 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 K + S K+ ++ II+ + L Y H + ++H D+KP N+LL KIADFG Sbjct: 129 YKEL-QKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGW 187 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTG 548 S H R T + GTL YL PE G TY ++D++ +GV+ E+L G Sbjct: 188 S--VHTPSLRRKT--MCGTLDYLPPEMIEGR-TYDEKVDLWCIGVLCYELLVG 235
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 75.9 bits (185), Expect = 1e-13 Identities = 55/172 (31%), Positives = 83/172 (48%), Gaps = 1/172 (0%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 +K+F R VE + H N+ + GY D ++ L EYL NG + Sbjct: 146 QKQFRREVEIQTSLNHPNLTKSYGY----------------FHDEKRVYLLMEYLVNGEM 189 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 K + I I L Y+H++NI+H D+KP NIL+ N V K+ DFG Sbjct: 190 YKLLR-LHGPFNDILASDYIYQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFGW 248 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTG 548 S + ++R TV GT+ YL+PE E + +D +++GV+ E+LTG Sbjct: 249 S-IINPPENRRKTV--CGTIDYLSPEMVESREYDHTIDAWALGVLAFELLTG 297
>IKKB_HUMAN (O14920) Inhibitor of nuclear factor kappa B kinase beta subunit| (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) Length = 756 Score = 75.9 bits (185), Expect = 1e-13 Identities = 50/158 (31%), Positives = 78/158 (49%), Gaps = 6/158 (3%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRK--CFQIIKGICQGLHYLHQRNILHLDLKPANIL 353 LL EY G L KY+ R+ ++ I L YLH+ I+H DLKP NI+ Sbjct: 93 LLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIV 152 Query: 354 L---DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVG 521 L + L+ KI D G ++ E+ ++ + GTL YLAPE + T +D +S G Sbjct: 153 LQQGEQRLIHKIIDLGYAK---ELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFG 209 Query: 522 VIIIEILTGKKGYLAVDNVVESWSNKLEKSQSDVQLKQ 635 + E +TG + +L V+ S +KS+ D+ + + Sbjct: 210 TLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSE 247
>NRKB_TRYBB (Q03428) Putative serine/threonine-protein kinase B (EC 2.7.11.1)| Length = 431 Score = 75.9 bits (185), Expect = 1e-13 Identities = 44/134 (32%), Positives = 70/134 (52%), Gaps = 5/134 (3%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYI----TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPAN 347 L+ E+ +G+LD+ I T +R Q + + +C L Y+H +LH D+K AN Sbjct: 93 LIVMEFADSGNLDEQIKPWGTGDARYFQEHEALFLFLQLCLALDYIHSHKMLHRDIKSAN 152 Query: 348 ILLDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGV 524 +LL + K+ DFG S + + S + GT YLAPE N + D++S+GV Sbjct: 153 VLLTSTGLVKLGDFGFSHQYEDTVSGVVASTFCGTPYYLAPELWNNLRYNKKADVWSLGV 212 Query: 525 IIIEILTGKKGYLA 566 ++ EI+ KK + A Sbjct: 213 LLYEIMGMKKPFSA 226
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 75.9 bits (185), Expect = 1e-13 Identities = 54/172 (31%), Positives = 81/172 (47%), Gaps = 1/172 (0%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 E + R VE ++H N++R GY D + L EY P G++ Sbjct: 168 EHQLRREVEIQSHLRHPNILRLYGY----------------FHDATRVYLILEYAPLGTV 211 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 + + S+ + R I + + L Y H + ++H D+KP N+LL N KIADFG Sbjct: 212 YRELQKLSKFDEQRTATYITE-LANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGW 270 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTG 548 S H SR T + GTL Y PE G + ++D++S+GV+ E L G Sbjct: 271 S--VHAPSSRRTT--LCGTLDYQPPEMIEGRMHDEKVDLWSLGVLCYEFLVG 318
>MOS_MSVMT (P32593) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 354 Score = 75.5 bits (184), Expect = 1e-13 Identities = 57/173 (32%), Positives = 86/173 (49%), Gaps = 11/173 (6%) Frame = +3 Query: 75 VKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDTSR---- 242 ++H N+VR + T G +M E+ N +L + I D +R Sbjct: 126 LRHDNIVRVVAASTRTPEDSNSL-GTIIM----------EFGGNVTLHQVIYDATRSPEP 174 Query: 243 -----KVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCF 407 ++ KC + + GL +LH ++ILHLDLKPANIL+ V KI+DFG S+ Sbjct: 175 LSCRKQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKL 234 Query: 408 HEMQSR-AITVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTGKKGY 560 ++ R A +I GT + APE GEI T + DIYS G+ + ++ T + Y Sbjct: 235 QVLRGRQASPPHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPY 287
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 75.5 bits (184), Expect = 1e-13 Identities = 57/177 (32%), Positives = 90/177 (50%), Gaps = 6/177 (3%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 EK+ R +E ++HKN++R G+ D ++ L E+ G L Sbjct: 131 EKQVRREIEIQSNLRHKNILRLYGH----------------FHDEKRIYLILEFAGRGEL 174 Query: 216 DKYITDTSR---KVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL--DGNLVPKI 380 +++ R +V + FQ+ L YLH+++++H D+KP NILL DG + K+ Sbjct: 175 YQHLRRAKRFSEEVASKYIFQM----ANALSYLHKKHVIHRDIKPENILLGIDGEI--KL 228 Query: 381 ADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTG 548 +DFG S H +R T + GTL YL PE G E T ++D++S+GV+ E L G Sbjct: 229 SDFGWS--VHAPSNRRTT--LCGTLDYLPPEMVEGKEHTEKVDLWSLGVLTYEFLVG 281
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/129 (35%), Positives = 72/129 (55%), Gaps = 5/129 (3%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRN--ILHLDLKPANILL 356 L +++ NGSL + + W +++K + G+ YLH +N +LH DLKP+N+L Sbjct: 92 LVTKFMENGSLSGLLQSQCPR-PWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLP 150 Query: 357 DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEF---CNGEITYQLDIYSVGVI 527 D L K+ADFG+S QS + GTLGYLAPE N + + D+YS G++ Sbjct: 151 DPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGIL 210 Query: 528 IIEILTGKK 554 + +L G++ Sbjct: 211 MWAVLAGRE 219
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 75.1 bits (183), Expect = 2e-13 Identities = 44/103 (42%), Positives = 63/103 (61%), Gaps = 2/103 (1%) Frame = +3 Query: 258 KCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSR-AIT 434 KC + + GL +LH ++ILHLDLKPANIL+ V KI+DFG S+ +++ R A Sbjct: 205 KCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQASP 264 Query: 435 VNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTGKKGY 560 +I GT + APE GEI T + DIYS G+ + ++ T + Y Sbjct: 265 HHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPY 307
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 75.1 bits (183), Expect = 2e-13 Identities = 49/181 (27%), Positives = 83/181 (45%), Gaps = 4/181 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY Q +A V Q + SL + Sbjct: 124 FKNEVGVLRKTRHVNILLFMGYSTKPQ-----------LAIVTQ------WCEGSSLYHH 166 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K + K I + QG+ YLH ++I+H DLK NI L +L KI DFG++ Sbjct: 167 LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV 226 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 + G++ ++APE ++Q D+Y+ G+++ E++TG+ Y ++ Sbjct: 227 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN 286 Query: 573 N 575 N Sbjct: 287 N 287
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 75.1 bits (183), Expect = 2e-13 Identities = 44/103 (42%), Positives = 63/103 (61%), Gaps = 2/103 (1%) Frame = +3 Query: 258 KCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSR-AIT 434 KC + + GL +LH ++ILHLDLKPANIL+ V KI+DFG S+ +++ R A Sbjct: 205 KCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQASP 264 Query: 435 VNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTGKKGY 560 +I GT + APE GEI T + DIYS G+ + ++ T + Y Sbjct: 265 HHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPY 307
>ST17A_HUMAN (Q9UEE5) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) Length = 414 Score = 75.1 bits (183), Expect = 2e-13 Identities = 48/146 (32%), Positives = 79/146 (54%), Gaps = 7/146 (4%) Frame = +3 Query: 156 VMADVQQRLLCFEYLPNGSL-DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLD 332 V + +L EY G + D+ + D + + ++++ I +G+H+LH R+++HLD Sbjct: 127 VYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLD 186 Query: 333 LKPANILLD-----GNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-IT 494 LKP NILL G++ KI DFG+SR + I GT Y+APE + + I+ Sbjct: 187 LKPQNILLTSESPLGDI--KIVDFGLSRILKNSEELR---EIMGTPEYVAPEILSYDPIS 241 Query: 495 YQLDIYSVGVIIIEILTGKKGYLAVD 572 D++S+GV+ +LTG +L D Sbjct: 242 MATDMWSIGVLTYVMLTGISPFLGND 267
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 75.1 bits (183), Expect = 2e-13 Identities = 49/181 (27%), Positives = 83/181 (45%), Gaps = 4/181 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY Q +A V Q + SL + Sbjct: 498 FKNEVGVLRKTRHVNILLFMGYSTKPQ-----------LAIVTQ------WCEGSSLYHH 540 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K + K I + QG+ YLH ++I+H DLK NI L +L KI DFG++ Sbjct: 541 LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV 600 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 + G++ ++APE ++Q D+Y+ G+++ E++TG+ Y ++ Sbjct: 601 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN 660 Query: 573 N 575 N Sbjct: 661 N 661
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 75.1 bits (183), Expect = 2e-13 Identities = 50/170 (29%), Positives = 92/170 (54%), Gaps = 6/170 (3%) Frame = +3 Query: 84 KNVVRFLGYCADTQGSMERYNG---KFVMADVQQRLLCFEYLPNGSLDKYITDTSRKVQW 254 K V FLG A G +N + V++ + ++ EY+ NG+LDK++ + + Sbjct: 655 KQRVDFLGE-AGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSV 713 Query: 255 RKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFH-EMQSRAI 431 + +++GI G+ YL N +H DL NIL++ NLV K++DFG+SR + ++ Sbjct: 714 LQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYT 773 Query: 432 TVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVIIIEILT-GKKGYLAVDN 575 T + + + APE + + T D++S G+++ E++T G++ Y + N Sbjct: 774 TSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSN 823
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 75.1 bits (183), Expect = 2e-13 Identities = 49/181 (27%), Positives = 83/181 (45%), Gaps = 4/181 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY Q +A V Q + SL + Sbjct: 60 FKNEVGVLRKTRHVNILLFMGYSTKPQ-----------LAIVTQ------WCEGSSLYHH 102 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K + K I + QG+ YLH ++I+H DLK NI L +L KI DFG++ Sbjct: 103 LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV 162 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 + G++ ++APE ++Q D+Y+ G+++ E++TG+ Y ++ Sbjct: 163 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN 222 Query: 573 N 575 N Sbjct: 223 N 223
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 75.1 bits (183), Expect = 2e-13 Identities = 49/181 (27%), Positives = 83/181 (45%), Gaps = 4/181 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY Q +A V Q + SL + Sbjct: 538 FKNEVGVLRKTRHVNILLFMGYSTKPQ-----------LAIVTQ------WCEGSSLYHH 580 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K + K I + QG+ YLH ++I+H DLK NI L +L KI DFG++ Sbjct: 581 LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV 640 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 + G++ ++APE ++Q D+Y+ G+++ E++TG+ Y ++ Sbjct: 641 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN 700 Query: 573 N 575 N Sbjct: 701 N 701
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 75.1 bits (183), Expect = 2e-13 Identities = 49/181 (27%), Positives = 83/181 (45%), Gaps = 4/181 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY Q +A V Q + SL + Sbjct: 108 FKNEVGVLRKTRHVNILLFMGYSTKPQ-----------LAIVTQ------WCEGSSLYHH 150 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K + K I + QG+ YLH ++I+H DLK NI L +L KI DFG++ Sbjct: 151 LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV 210 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 + G++ ++APE ++Q D+Y+ G+++ E++TG+ Y ++ Sbjct: 211 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN 270 Query: 573 N 575 N Sbjct: 271 N 271
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 75.1 bits (183), Expect = 2e-13 Identities = 50/177 (28%), Positives = 84/177 (47%), Gaps = 6/177 (3%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 E+ F ++ + H NV+ LG+CA Q + Y+ NGSL Sbjct: 251 ERFFQAELQICLRCCHPNVLPVLGFCAARQFHS----------------FIYPYMANGSL 294 Query: 216 DKYITDT--SRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADF 389 + S + W + I G+ + YLH I+H ++K +N+LLD NL PK+A Sbjct: 295 QDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHP 354 Query: 390 GVSRCFHEMQSRAITVN---IRGTLGYLAPEFCN-GEITYQLDIYSVGVIIIEILTG 548 C +S+ + +R + YL +F G++T ++DI+S G+++ E+LTG Sbjct: 355 MAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTG 411
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 75.1 bits (183), Expect = 2e-13 Identities = 42/136 (30%), Positives = 74/136 (54%), Gaps = 1/136 (0%) Frame = +3 Query: 156 VMADVQQRLLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDL 335 V AD + EY+ +L K I + K+++ K I + L++ H+ I+H D+ Sbjct: 76 VGADGNVNYIVMEYVAGKTLKKLIKENG-KIEFNKIIDYATQIAKALNFAHKNGIVHRDI 134 Query: 336 KPANILLDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIY 512 KP NI++ + + K+ DFG+++ +E + T + G+ YL+PE G + + DIY Sbjct: 135 KPHNIMVTDDDIIKVTDFGIAKASNE-STITTTNKVVGSAHYLSPEQAQGIPVDCRTDIY 193 Query: 513 SVGVIIIEILTGKKGY 560 S G+++ E+ TGK Y Sbjct: 194 SFGIVLYEMATGKVPY 209
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 75.1 bits (183), Expect = 2e-13 Identities = 49/181 (27%), Positives = 83/181 (45%), Gaps = 4/181 (2%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L +H N++ F+GY Q +A V Q + SL + Sbjct: 538 FKNEVGVLRKTRHVNILLFMGYSTKPQ-----------LAIVTQ------WCEGSSLYHH 580 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + K + K I + QG+ YLH ++I+H DLK NI L +L KI DFG++ Sbjct: 581 LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV 640 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFC----NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 + G++ ++APE ++Q D+Y+ G+++ E++TG+ Y ++ Sbjct: 641 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN 700 Query: 573 N 575 N Sbjct: 701 N 701
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 74.7 bits (182), Expect = 2e-13 Identities = 59/185 (31%), Positives = 94/185 (50%), Gaps = 18/185 (9%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F V L ++H NVV+FLG C T G + + + E++ GSL ++ Sbjct: 1332 FQNEVGILSKLRHPNVVQFLGAC--TAGGEDHH------------CIVTEWMGGGSLRQF 1377 Query: 225 ITDTSRKVQWRKCFQI--IKGICQGLHYLHQRN--ILHLDLKPANILLDGNLVP------ 374 +TD ++ ++ I +G++YLH ILH DL NILLD N+ P Sbjct: 1378 LTDHFNLLEQNPHIRLKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVS 1437 Query: 375 -------KIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVII 530 KI+DFG+SR E Q+ +T ++ G + Y+APE G+ + + D+YS G+++ Sbjct: 1438 SRQDIKCKISDFGLSRLKKE-QASQMTQSV-GCIPYMAPEVFKGDSNSEKSDVYSYGMVL 1495 Query: 531 IEILT 545 E+LT Sbjct: 1496 FELLT 1500
>CHK1_CAEEL (Q9N3Z3) Serine/threonine-protein kinase chk-1 (EC 2.7.11.1)| Length = 503 Score = 74.7 bits (182), Expect = 2e-13 Identities = 52/186 (27%), Positives = 88/186 (47%), Gaps = 4/186 (2%) Frame = +3 Query: 75 VKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL-DKYITDTSRKVQ 251 V H NV+R +G + D Q L EY G L DK D Sbjct: 82 VGHDNVIRMIG----------------MRNDPQFYYLFLEYADGGELFDKIEPDCGMSPV 125 Query: 252 WRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSRAI 431 + + + K + GL ++H +++H D+KP N+LL G V KI+DFG++ + + Sbjct: 126 FAQFY--FKQLICGLKFIHDNDVVHRDIKPENLLLTGTHVLKISDFGMATLYRNKGEERL 183 Query: 432 TVNIRGTLGYLAPEFCNGEITYQ---LDIYSVGVIIIEILTGKKGYLAVDNVVESWSNKL 602 GT+ Y APE C G+ Y+ +D++S G+++I +LTG+ + + +S+ + Sbjct: 184 LDLSCGTIPYAAPELCAGK-KYRGPPVDVWSSGIVLIAMLTGELPWDRASDASQSYMGWI 242 Query: 603 EKSQSD 620 + D Sbjct: 243 SNTSLD 248
>IKKB_RAT (Q9QY78) Inhibitor of nuclear factor kappa B kinase beta subunit| (EC 2.7.11.1) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) Length = 757 Score = 74.7 bits (182), Expect = 2e-13 Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 6/158 (3%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRK--CFQIIKGICQGLHYLHQRNILHLDLKPANIL 353 LL EY G L +Y+ R+ ++ I L YLH+ I+H DLKP NI+ Sbjct: 93 LLAMEYCQGGDLRRYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIV 152 Query: 354 L---DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVG 521 L + L+ KI D G ++ E+ ++ + GTL YLAPE + T +D +S G Sbjct: 153 LQQGEKRLIHKIIDLGYAK---ELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFG 209 Query: 522 VIIIEILTGKKGYLAVDNVVESWSNKLEKSQSDVQLKQ 635 + E +TG + +L V+ S +KS+ D+ + + Sbjct: 210 TLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSE 247
>IKKB_MOUSE (O88351) Inhibitor of nuclear factor kappa B kinase beta subunit| (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) Length = 757 Score = 74.7 bits (182), Expect = 2e-13 Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 6/158 (3%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRK--CFQIIKGICQGLHYLHQRNILHLDLKPANIL 353 LL EY G L +Y+ R+ ++ I L YLH+ I+H DLKP NI+ Sbjct: 93 LLAMEYCQGGDLRRYLNQFENCCGLREGAVLTLLSDIASALRYLHENRIIHRDLKPENIV 152 Query: 354 L---DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVG 521 L + L+ KI D G ++ E+ ++ + GTL YLAPE + T +D +S G Sbjct: 153 LQQGEKRLIHKIIDLGYAK---ELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFG 209 Query: 522 VIIIEILTGKKGYLAVDNVVESWSNKLEKSQSDVQLKQ 635 + E +TG + +L V+ S +KS+ D+ + + Sbjct: 210 TLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSE 247
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 74.7 bits (182), Expect = 2e-13 Identities = 42/143 (29%), Positives = 82/143 (57%), Gaps = 3/143 (2%) Frame = +3 Query: 156 VMADVQQRLLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDL 335 V++ + ++ EY+ NG+LDK++ + + + +++GI G+ YL N +H DL Sbjct: 682 VVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIASGMKYLANMNYVHRDL 741 Query: 336 KPANILLDGNLVPKIADFGVSRCFH-EMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDI 509 NIL++ NLV K++DFG+SR + ++ T + + + APE + + T D+ Sbjct: 742 AARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDV 801 Query: 510 YSVGVIIIEILT-GKKGYLAVDN 575 +S G+++ E++T G++ Y + N Sbjct: 802 WSYGIVMWEVMTYGERPYWELSN 824
>MYLK2_RAT (P20689) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 609 Score = 74.3 bits (181), Expect = 3e-13 Identities = 51/145 (35%), Positives = 84/145 (57%), Gaps = 4/145 (2%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL-- 353 +L EY+ G L + I D ++ ++ IC G+ ++H+ +LHLDLKP NIL Sbjct: 369 ILFMEYIEGGELFERIVDEDYQLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCV 428 Query: 354 -LDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVI 527 G+LV KI DFG++R ++ + + VN GT +L+PE N +I+ + D++S+GVI Sbjct: 429 NTTGHLV-KIIDFGLARRYN--PNEKLKVNF-GTPEFLSPEVVNYDQISDKTDMWSLGVI 484 Query: 528 IIEILTGKKGYLAVDNVVESWSNKL 602 +L+G +L D+ E+ +N L Sbjct: 485 TYMLLSGLSPFLG-DDDTETLNNVL 508
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 74.3 bits (181), Expect = 3e-13 Identities = 50/181 (27%), Positives = 92/181 (50%), Gaps = 11/181 (6%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K F +E L++ H N++ Y +T+ KF L + Y+ NG+L Sbjct: 207 KRFLSELEVLLLFHHPNILELAAYFTETE--------KFC--------LIYPYMRNGTLF 250 Query: 219 ---KYITDTSRKVQWRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLVPKI 380 + + DT+ + W I+ GI + +HYLH +++ + ANILLD PK+ Sbjct: 251 DRLQCVGDTA-PLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKL 309 Query: 381 ADFGVSRCFHEMQSRAITVNIRGT----LGYLAPEFC-NGEITYQLDIYSVGVIIIEILT 545 DF ++ ++ ++ T+N+ + L Y+ E+ G+++ + D+YS G++I+E+LT Sbjct: 310 TDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLT 369 Query: 546 G 548 G Sbjct: 370 G 370
>SHARK_DROME (Q24145) Tyrosine-protein kinase shark (EC 2.7.10.2)| Length = 939 Score = 74.3 bits (181), Expect = 3e-13 Identities = 61/219 (27%), Positives = 101/219 (46%), Gaps = 4/219 (1%) Frame = +3 Query: 3 AVXXLSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRL 182 A+ LS+ H ++EF R +M ++HK +VR +G +A + + Sbjct: 696 AIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIG-----------------IAKGEMLM 738 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQI-IKGICQGLHYLHQRNILHLDLKPANILLD 359 + E P GS+ +YI D ++ ++ I G+HYL ++ +H DL NILL Sbjct: 739 MVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLT 798 Query: 360 GNLVPKIADFGVSRCFHEMQSR-AITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVIII 533 KI+DFG+SR + T R + + APE N G ++ D++S GV I Sbjct: 799 ARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIW 858 Query: 534 EILT-GKKGYLAVDNVVESWSNKLEKSQSDVQLKQVRIC 647 E+ + G Y + NV + ++ S +L Q +C Sbjct: 859 EMFSLGAPPYGEISNV-----DAIKLVDSGERLPQPNLC 892
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 73.9 bits (180), Expect = 4e-13 Identities = 53/142 (37%), Positives = 78/142 (54%), Gaps = 11/142 (7%) Frame = +3 Query: 192 EYLPNGSLDKYITDTSR--KVQWRKCFQIIKGICQGLHYLHQRN--ILHLDLKPANILLD 359 EY+PNGSL++ + + + W F+I+ I G++YLH N +LH DLK NILLD Sbjct: 96 EYMPNGSLNELLHRKTEYPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLD 155 Query: 360 GNLVPKIADFGVS--RCFHEMQSRAI-TVNIRGTLGYLAPEFC----NGEITYQLDIYSV 518 KIADFG+S R QSR+ + GT+ Y+ PE + + DIYS Sbjct: 156 NEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSY 215 Query: 519 GVIIIEILTGKKGYLAVDNVVE 584 VI+ E+L+ K+ + V N ++ Sbjct: 216 AVIMWEVLSRKQPFEEVTNPLQ 237
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 73.9 bits (180), Expect = 4e-13 Identities = 56/181 (30%), Positives = 88/181 (48%), Gaps = 5/181 (2%) Frame = +3 Query: 24 THMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLP 203 T + +E V+ L + H N+VR+LG + D LL E++P Sbjct: 112 TQAHIQELEEEVKLLKNLSHPNIVRYLGTVRED--------------DTLNILL--EFVP 155 Query: 204 NGS----LDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLV 371 GS L+K+ V+ + + GL YLH I+H D+K ANIL+D Sbjct: 156 GGSISSLLEKFGPFPESVVR-----TYTRQLLLGLEYLHNHAIMHRDIKGANILVDNKGC 210 Query: 372 PKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILTG 548 K+ADFG S+ E+ + +++GT ++APE ++ DI+SVG +IE++TG Sbjct: 211 IKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTG 270 Query: 549 K 551 K Sbjct: 271 K 271
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 73.9 bits (180), Expect = 4e-13 Identities = 59/172 (34%), Positives = 85/172 (49%), Gaps = 5/172 (2%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R V L +KH NVVR L V+ + L FE+L + L KY+ Sbjct: 50 REVSLLQELKHPNVVRLLD----------------VLMQESRLYLIFEFL-SMDLKKYL- 91 Query: 231 DTSRKVQWRKCFQI---IKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSR 401 D+ Q+ + + I +G+++ H+R +LH DLKP N+L+D V K+ADFG+SR Sbjct: 92 DSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLSR 151 Query: 402 CFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ--LDIYSVGVIIIEILTGK 551 F + R T + TL Y APE G Y +D++S G I E+ T K Sbjct: 152 AF-GVPVRVYTHEV-VTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKK 201
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 73.9 bits (180), Expect = 4e-13 Identities = 56/181 (30%), Positives = 88/181 (48%), Gaps = 5/181 (2%) Frame = +3 Query: 24 THMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLP 203 T + +E V+ L + H N+VR+LG T E N + E++P Sbjct: 111 TQAHIQELEEEVKLLKNLSHPNIVRYLG----TVREDETLN------------ILLEFVP 154 Query: 204 NGS----LDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLV 371 GS L+K+ V+ + GL YLH I+H D+K ANIL+D Sbjct: 155 GGSISSLLEKFGAFPESVVR-----TYTNQLLLGLEYLHNHAIMHRDIKGANILVDNQGC 209 Query: 372 PKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILTG 548 K+ADFG S+ E+ + + +++GT ++APE ++ DI+SVG +IE++TG Sbjct: 210 IKLADFGASKQVAELATISGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTG 269 Query: 549 K 551 K Sbjct: 270 K 270
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 73.9 bits (180), Expect = 4e-13 Identities = 51/196 (26%), Positives = 89/196 (45%), Gaps = 17/196 (8%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K+F R E L ++H+++V+F G C D ++ FEY+ +G L+ Sbjct: 583 KDFQREAELLTNLQHEHIVKFYGVCGDGD----------------PLIMVFEYMKHGDLN 626 Query: 219 KYIT---------------DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL 353 K++ ++ + I IC G+ YL ++ +H DL N L Sbjct: 627 KFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQICSGMVYLASQHFVHRDLATRNCL 686 Query: 354 LDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVII 530 + NL+ KI DFG+SR + + + + ++ PE + T + D++S GVI+ Sbjct: 687 VGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVIL 746 Query: 531 IEILT-GKKGYLAVDN 575 EI T GK+ + + N Sbjct: 747 WEIFTYGKQPWFQLSN 762
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 73.9 bits (180), Expect = 4e-13 Identities = 59/191 (30%), Positives = 94/191 (49%), Gaps = 9/191 (4%) Frame = +3 Query: 3 AVXXLSNTHMYEK----EFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADV 170 A+ +S H+ K R VE L M+ H N+++ + D N ++++DV Sbjct: 96 AIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYEFFEDN-------NYYYLVSDV 148 Query: 171 QQRLLCFEYLPNGSLDKYITDTSRKVQWR-KCFQIIKGICQGLHYLHQRNILHLDLKPAN 347 Y D+ I SRK + +IIK I G+ Y+H+ N++H DLKP N Sbjct: 149 --------YTGGELFDEII---SRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPEN 197 Query: 348 ILLD----GNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQLDIYS 515 ILL+ +++ KI DFG+S F + + GT Y+AP+ +G + DI+S Sbjct: 198 ILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKI---GTAYYIAPDVLHGTYDEKCDIWS 254 Query: 516 VGVIIIEILTG 548 GVI+ +L+G Sbjct: 255 CGVILYILLSG 265
>LRRK2_HUMAN (Q5S007) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) (Dardarin) Length = 2527 Score = 73.6 bits (179), Expect = 5e-13 Identities = 44/135 (32%), Positives = 70/135 (51%), Gaps = 7/135 (5%) Frame = +3 Query: 162 ADVQQRLLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKP 341 A ++ R+L E GSLD+ + + +I + GL YLH I++ DLKP Sbjct: 1938 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKP 1997 Query: 342 ANILL-----DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--Q 500 N+LL + ++ KIAD+G+++ M + GT G+ APE G + Y Q Sbjct: 1998 HNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIK----TSEGTPGFRAPEVARGNVIYNQQ 2053 Query: 501 LDIYSVGVIIIEILT 545 D+YS G+++ +ILT Sbjct: 2054 ADVYSFGLLLYDILT 2068
>RKIN1_SECCE (Q02723) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 502 Score = 73.6 bits (179), Expect = 5e-13 Identities = 42/121 (34%), Positives = 67/121 (55%), Gaps = 2/121 (1%) Frame = +3 Query: 192 EYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLV 371 EY NG L YI + R++Q + + + I + Y H+ ++H DLKP N+LLD Sbjct: 95 EYCQNGDLLDYILE-KRRLQEDEARRTFQQIISAVEYCHRNKVVHRDLKPENLLLDSKYN 153 Query: 372 PKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILT 545 K+ADFG+S H+ + G+L Y APE +G++ ++D++S GVI+ +L Sbjct: 154 VKLADFGLSNVMHDGHFLKTSC---GSLNYAAPEVISGKLYAGPEIDVWSCGVILYALLC 210 Query: 546 G 548 G Sbjct: 211 G 211
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 73.6 bits (179), Expect = 5e-13 Identities = 54/173 (31%), Positives = 83/173 (47%), Gaps = 2/173 (1%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRL-LCFEYLPNGS 212 E + R +E +KH N+++ Y D QQR+ L EY P G Sbjct: 124 EHQLRREIEIQAHLKHPNILQLYNYFYD-----------------QQRIYLILEYAPRGE 166 Query: 213 LDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFG 392 L K + SR ++ I++ + L Y H++ ++H D+KP N+LL KIADFG Sbjct: 167 LYKEL-QKSRTFDEQRTATIMEELSDALTYCHKKKVIHRDIKPENLLLGLQGELKIADFG 225 Query: 393 VSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQL-DIYSVGVIIIEILTG 548 S H R T + GTL YL PE G + ++ D++ +GV+ E++ G Sbjct: 226 WS--VHAPSLRRKT--MCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVG 274
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 73.6 bits (179), Expect = 5e-13 Identities = 50/177 (28%), Positives = 83/177 (46%), Gaps = 1/177 (0%) Frame = +3 Query: 24 THMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLP 203 T + +E V+ L + H N+VR+LG ++ + E++P Sbjct: 111 TQGHIRELEEEVQLLKNLSHPNIVRYLGTVRESDSLN----------------ILMEFVP 154 Query: 204 NGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIA 383 GS+ + + K + GL YLH I+H D+K ANIL+D ++A Sbjct: 155 GGSISSLLEKFGSFPE-PVIIMYTKQLLLGLEYLHNNGIMHRDIKGANILVDNKGCIRLA 213 Query: 384 DFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILTGK 551 DFG S+ E+ + +++GT ++APE ++ DI+SVG +IE+ TGK Sbjct: 214 DFGASKKVVELATVNGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMATGK 270
>MOS_MOUSE (P00536) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 390 Score = 73.6 bits (179), Expect = 5e-13 Identities = 44/103 (42%), Positives = 62/103 (60%), Gaps = 2/103 (1%) Frame = +3 Query: 258 KCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSR-AIT 434 KC + + GL +LH ++ILHLDLKPANIL+ V KI+DFG S+ ++ R A Sbjct: 221 KCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQVLRCRQASP 280 Query: 435 VNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTGKKGY 560 +I GT + APE GEI T + DIYS G+ + ++ T + Y Sbjct: 281 HHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPY 323
>ST17A_RABIT (Q9GM70) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) (rDRAK1) Length = 397 Score = 73.6 bits (179), Expect = 5e-13 Identities = 49/148 (33%), Positives = 81/148 (54%), Gaps = 7/148 (4%) Frame = +3 Query: 174 QRLLCFEYLPNGSL-DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANI 350 + +L EY G + D+ + D + ++++ I +G+H+LH +++HLDLKP NI Sbjct: 116 EMILVLEYAAGGEISDQCVADRDEAFNEKDVQRLMRQILEGVHFLHTHDVVHLDLKPQNI 175 Query: 351 LLD-----GNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIY 512 LL G++ KI DFG+SR + I GT Y+APE + + I+ D++ Sbjct: 176 LLTSESPLGDI--KIVDFGLSRIVKNSEELR---EIMGTPEYVAPEILSYDPISMATDMW 230 Query: 513 SVGVIIIEILTGKKGYLAVDNVVESWSN 596 S+GV+ +LTG +L DN E++ N Sbjct: 231 SIGVLTYVMLTGISPFLG-DNKQETFLN 257
>CC2H1_TRYCO (P54664) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 73.2 bits (178), Expect = 6e-13 Identities = 53/168 (31%), Positives = 82/168 (48%), Gaps = 2/168 (1%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R + L ++H+N+VR L C S R N L FEY+ L KY+ Sbjct: 51 REISILKELRHENIVRLLDVCH----SENRLN------------LVFEYMEM-DLKKYMD 93 Query: 231 DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFH 410 S + + ++ + +G+ + H+RN+LH DLKP N+L+ K+ADFG+ R F Sbjct: 94 RASGNLDPATIQEFMRSLLKGVRFCHERNVLHRDLKPPNLLISREKELKLADFGLGRAF- 152 Query: 411 EMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTG 548 + + T + TL Y +P+ G Y +DI+SVG I E+ G Sbjct: 153 GIPVKKYTHEV-VTLWYRSPDVLLGSTQYGTPVDIWSVGCIFAEMAIG 199
>MYLK2_HUMAN (Q9H1R3) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 595 Score = 73.2 bits (178), Expect = 6e-13 Identities = 51/145 (35%), Positives = 83/145 (57%), Gaps = 4/145 (2%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL-- 353 +L EY+ G L + I D + ++ IC G+ ++H+ +LHLDLKP NIL Sbjct: 355 VLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCV 414 Query: 354 -LDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVI 527 G+LV KI DFG++R ++ + + VN GT +L+PE N +I+ + D++S+GVI Sbjct: 415 NTTGHLV-KIIDFGLARRYN--PNEKLKVNF-GTPEFLSPEVVNYDQISDKTDMWSMGVI 470 Query: 528 IIEILTGKKGYLAVDNVVESWSNKL 602 +L+G +L D+ E+ +N L Sbjct: 471 TYMLLSGLSPFLG-DDDTETLNNVL 494
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 73.2 bits (178), Expect = 6e-13 Identities = 53/173 (30%), Positives = 81/173 (46%), Gaps = 1/173 (0%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 E + R VE ++H+N++R Y D + L EY P G L Sbjct: 58 EHQLRREVEIQAHLQHRNILRLYNYFYDDT----------------RIYLILEYAPGGEL 101 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 K + +K+ ++ II+ + L Y H++ ++H D+KP N+LL N KI+DFG Sbjct: 102 YKEL-QRHQKLDQQRTATIIQELSDALTYCHEKKVIHRDIKPENLLLGLNGEVKISDFGW 160 Query: 396 SRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILTGK 551 S H R T + GTL YL PE +D++ +GV+ E+L GK Sbjct: 161 S--VHTPSLRRKT--MCGTLDYLPPEMIAQKPYNEMVDLWCIGVLCYELLVGK 209
>DAPK3_HUMAN (O43293) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 454 Score = 73.2 bits (178), Expect = 6e-13 Identities = 51/180 (28%), Positives = 86/180 (47%), Gaps = 5/180 (2%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 +E R V L ++H N++ + + +L E + G L Sbjct: 59 EEIEREVNILREIRHPNIITLHD----------------IFENKTDVVLILELVSGGELF 102 Query: 219 KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVP----KIAD 386 ++ + + + Q +K I G+HYLH + I H DLKP NI+L VP K+ D Sbjct: 103 DFLAEKESLTE-DEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLID 161 Query: 387 FGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYL 563 FG++ H++++ NI GT ++APE N E + + D++S+GVI +L+G +L Sbjct: 162 FGIA---HKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFL 218
>MKK2_YEAST (P32491) MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2)| Length = 506 Score = 73.2 bits (178), Expect = 6e-13 Identities = 51/177 (28%), Positives = 87/177 (49%), Gaps = 4/177 (2%) Frame = +3 Query: 33 YEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGS 212 Y+K+ R ++ K +V++ G D Q S + EY+ S Sbjct: 254 YQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSS--------------SIYIAMEYMGGKS 299 Query: 213 LD---KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIA 383 L+ K + ++ R +I + + +GL YLH+R ++H D+KP NILL+ K+ Sbjct: 300 LEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLC 359 Query: 384 DFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGK 551 DFGVS + S A+T GT Y+APE G+ + D++S+G+ ++E+ G+ Sbjct: 360 DFGVSG--EAVNSLAMT--FTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGR 412
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 73.2 bits (178), Expect = 6e-13 Identities = 56/190 (29%), Positives = 93/190 (48%), Gaps = 8/190 (4%) Frame = +3 Query: 3 AVXXLSNTHMYEK----EFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADV 170 A+ +S H+ K R VE L M+ H N+++ + D N ++++DV Sbjct: 96 AIKVISKKHVKRKTDKQSLLREVELLKMLDHINIMKLYEFFEDN-------NYYYLVSDV 148 Query: 171 QQRLLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANI 350 F+ + + Y D +R IIK + G+ Y+H+ N++H DLKP NI Sbjct: 149 YSGGELFDEIISRKRF-YEVDAAR---------IIKQVLSGITYMHKNNVVHRDLKPENI 198 Query: 351 LLD----GNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQLDIYSV 518 LL+ +++ KI DFG+S F + + GT Y+AP+ +G + DI+S Sbjct: 199 LLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKI---GTAYYIAPDVLHGTYDEKCDIWSC 255 Query: 519 GVIIIEILTG 548 GVI+ +L+G Sbjct: 256 GVILYILLSG 265
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 73.2 bits (178), Expect = 6e-13 Identities = 56/190 (29%), Positives = 93/190 (48%), Gaps = 8/190 (4%) Frame = +3 Query: 3 AVXXLSNTHMYEK----EFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADV 170 A+ +S H+ K R VE L M+ H N+++ + D N ++++DV Sbjct: 96 AIKVISKKHVKRKTDKQSLLREVELLKMLDHINIMKLYEFFEDN-------NYYYLVSDV 148 Query: 171 QQRLLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANI 350 F+ + + Y D +R IIK + G+ Y+H+ N++H DLKP NI Sbjct: 149 YSGGELFDEIISRKRF-YEVDAAR---------IIKQVLSGITYMHKNNVVHRDLKPENI 198 Query: 351 LLD----GNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQLDIYSV 518 LL+ +++ KI DFG+S F + + GT Y+AP+ +G + DI+S Sbjct: 199 LLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKI---GTAYYIAPDVLHGTYDEKCDIWSC 255 Query: 519 GVIIIEILTG 548 GVI+ +L+G Sbjct: 256 GVILYILLSG 265
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 73.2 bits (178), Expect = 6e-13 Identities = 41/127 (32%), Positives = 69/127 (54%), Gaps = 1/127 (0%) Frame = +3 Query: 174 QRLLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL 353 Q+ + E++ +L +YI + + +II I + H I+H DLKP N+L Sbjct: 85 QQYIVMEFVDGMTLKQYINQNAPLAN-DEAIEIITEILSAMDMAHSHGIIHRDLKPQNVL 143 Query: 354 LDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVII 530 + + K+ DFG+++ E S T + G++ YL+PE G T Q DIY++G+I+ Sbjct: 144 VSSSGTVKVTDFGIAKALSE-TSLTQTNTMFGSVHYLSPEQARGSNATVQSDIYAIGIIL 202 Query: 531 IEILTGK 551 E+LTG+ Sbjct: 203 FELLTGQ 209
>SKM1_YEAST (Q12469) Serine/threonine-protein kinase SKM1 (EC 2.7.11.1)| (Protein kinase 75490 D) Length = 655 Score = 73.2 bits (178), Expect = 6e-13 Identities = 44/145 (30%), Positives = 76/145 (52%), Gaps = 9/145 (6%) Frame = +3 Query: 165 DVQQRLLCFEYLPNGSLDKYITDTSRK--------VQWRKCFQIIKGICQGLHYLHQRNI 320 D ++ + EY+ G L + +R + + I+K CQGL +LH + I Sbjct: 444 DDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKI 503 Query: 321 LHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITY 497 +H D+K NILL+ + KI DFG C + R+ + GT ++APE N + Sbjct: 504 IHRDIKSDNILLNSQGLVKITDFGF--CVELTEKRSKRATMVGTPYWMAPEIVNQKGYDE 561 Query: 498 QLDIYSVGVIIIEILTGKKGYLAVD 572 ++D++S+G+++IE++ G+ YL D Sbjct: 562 KVDVWSLGIMLIEMIEGEPPYLNED 586
>MYLK2_RABIT (P07313) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) Length = 607 Score = 73.2 bits (178), Expect = 6e-13 Identities = 51/145 (35%), Positives = 83/145 (57%), Gaps = 4/145 (2%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL-- 353 +L EY+ G L + I D + ++ IC G+ ++H+ +LHLDLKP NIL Sbjct: 367 VLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCV 426 Query: 354 -LDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVI 527 G+LV KI DFG++R ++ + + VN GT +L+PE N +I+ + D++S+GVI Sbjct: 427 NTTGHLV-KIIDFGLARRYN--PNEKLKVNF-GTPEFLSPEVVNYDQISDKTDMWSLGVI 482 Query: 528 IIEILTGKKGYLAVDNVVESWSNKL 602 +L+G +L D+ E+ +N L Sbjct: 483 TYMLLSGLSPFLG-DDDTETLNNVL 506
>MYLK_CHICK (P11799) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin] Length = 1906 Score = 72.8 bits (177), Expect = 8e-13 Identities = 46/143 (32%), Positives = 83/143 (58%), Gaps = 4/143 (2%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL- 356 ++ E + G L + I D ++ R+C + ++ I +G+ Y+H++ I+HLDLKP NI+ Sbjct: 1524 VMVLEMVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 1583 Query: 357 --DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVI 527 G + K+ DFG++R ++S + GT ++APE N E I Y+ D++S+GVI Sbjct: 1584 NKTGTSI-KLIDFGLAR---RLESAGSLKVLFGTPEFVAPEVINYEPIGYETDMWSIGVI 1639 Query: 528 IIEILTGKKGYLAVDNVVESWSN 596 +++G ++ DN E+ +N Sbjct: 1640 CYILVSGLSPFMG-DNDNETLAN 1661
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 72.8 bits (177), Expect = 8e-13 Identities = 58/172 (33%), Positives = 85/172 (49%), Gaps = 5/172 (2%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R V L +KH NVVR L V+ + L FE+L + L KY+ Sbjct: 50 REVSLLQELKHPNVVRLLD----------------VLMQESRLYLIFEFL-SMDLKKYL- 91 Query: 231 DTSRKVQWRKCFQI---IKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSR 401 D+ Q+ + + I +G+++ H+R +LH DLKP N+L+D V K+ADFG++R Sbjct: 92 DSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLAR 151 Query: 402 CFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ--LDIYSVGVIIIEILTGK 551 F + R T + TL Y APE G Y +D++S G I E+ T K Sbjct: 152 AF-GVPVRVYTHEV-VTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKK 201
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 72.8 bits (177), Expect = 8e-13 Identities = 58/172 (33%), Positives = 85/172 (49%), Gaps = 5/172 (2%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R V L +KH NVVR L V+ + L FE+L + L KY+ Sbjct: 50 REVSLLQELKHPNVVRLLD----------------VLMQESRLYLIFEFL-SMDLKKYL- 91 Query: 231 DTSRKVQWRKCFQI---IKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSR 401 D+ Q+ + + I +G+++ H+R +LH DLKP N+L+D V K+ADFG++R Sbjct: 92 DSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLAR 151 Query: 402 CFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ--LDIYSVGVIIIEILTGK 551 F + R T + TL Y APE G Y +D++S G I E+ T K Sbjct: 152 AF-GVPVRVYTHEV-VTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKK 201
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 72.8 bits (177), Expect = 8e-13 Identities = 58/172 (33%), Positives = 85/172 (49%), Gaps = 5/172 (2%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R V L +KH NVVR L V+ + L FE+L + L KY+ Sbjct: 50 REVSLLQELKHPNVVRLLD----------------VLMQESRLYLIFEFL-SMDLKKYL- 91 Query: 231 DTSRKVQWRKCFQI---IKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSR 401 D+ Q+ + + I +G+++ H+R +LH DLKP N+L+D V K+ADFG++R Sbjct: 92 DSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLAR 151 Query: 402 CFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ--LDIYSVGVIIIEILTGK 551 F + R T + TL Y APE G Y +D++S G I E+ T K Sbjct: 152 AF-GVPVRVYTHEV-VTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKK 201
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/193 (25%), Positives = 92/193 (47%), Gaps = 14/193 (7%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K+FHR E L ++H+++V+F G C + ++ FEY+ +G L+ Sbjct: 582 KDFHREAELLTNLQHEHIVKFYGVCVEGD----------------PLIMVFEYMKHGDLN 625 Query: 219 KYIT------------DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 K++ + ++ + I + I G+ YL ++ +H DL N L+ Sbjct: 626 KFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE 685 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEI 539 NL+ KI DFG+SR + + + + ++ PE + T + D++S+GV++ EI Sbjct: 686 NLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEI 745 Query: 540 LT-GKKGYLAVDN 575 T GK+ + + N Sbjct: 746 FTYGKQPWYQLSN 758
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/193 (25%), Positives = 92/193 (47%), Gaps = 14/193 (7%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K+FHR E L ++H+++V+F G C + ++ FEY+ +G L+ Sbjct: 582 KDFHREAELLTNLQHEHIVKFYGVCVEGD----------------PLIMVFEYMKHGDLN 625 Query: 219 KYIT------------DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 K++ + ++ + I + I G+ YL ++ +H DL N L+ Sbjct: 626 KFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE 685 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEI 539 NL+ KI DFG+SR + + + + ++ PE + T + D++S+GV++ EI Sbjct: 686 NLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEI 745 Query: 540 LT-GKKGYLAVDN 575 T GK+ + + N Sbjct: 746 FTYGKQPWYQLSN 758
>MYLK2_MOUSE (Q8VCR8) Myosin light chain kinase 2, skeletal/cardiac muscle (EC| 2.7.11.18) (MLCK2) (Fragment) Length = 240 Score = 72.8 bits (177), Expect = 8e-13 Identities = 51/144 (35%), Positives = 82/144 (56%), Gaps = 4/144 (2%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL--- 353 L EY+ G L + I D + ++ IC G+ ++H+ +LHLDLKP NIL Sbjct: 1 LFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVN 60 Query: 354 LDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVII 530 G+LV KI DFG++R ++ + + VN GT +L+PE N +I+ + D++S+GVI Sbjct: 61 TTGHLV-KIIDFGLARRYN--PNEKLKVNF-GTPEFLSPEVVNYDQISDKTDMWSLGVIT 116 Query: 531 IEILTGKKGYLAVDNVVESWSNKL 602 +L+G +L D+ E+ +N L Sbjct: 117 YMLLSGLSPFLG-DDDTETLNNVL 139
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/193 (25%), Positives = 92/193 (47%), Gaps = 14/193 (7%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K+FHR E L ++H+++V+F G C + ++ FEY+ +G L+ Sbjct: 579 KDFHREAELLTNLQHEHIVKFYGVCVEGD----------------PLIMVFEYMKHGDLN 622 Query: 219 KYIT------------DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 K++ + ++ + I + I G+ YL ++ +H DL N L+ Sbjct: 623 KFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE 682 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEI 539 NL+ KI DFG+SR + + + + ++ PE + T + D++S+GV++ EI Sbjct: 683 NLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEI 742 Query: 540 LT-GKKGYLAVDN 575 T GK+ + + N Sbjct: 743 FTYGKQPWYQLSN 755
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/193 (25%), Positives = 92/193 (47%), Gaps = 14/193 (7%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K+FHR E L ++H+++V+F G C + ++ FEY+ +G L+ Sbjct: 583 KDFHREAELLTNLQHEHIVKFYGVCVEGD----------------PLIMVFEYMKHGDLN 626 Query: 219 KYIT------------DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 K++ + ++ + I + I G+ YL ++ +H DL N L+ Sbjct: 627 KFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE 686 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEI 539 NL+ KI DFG+SR + + + + ++ PE + T + D++S+GV++ EI Sbjct: 687 NLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEI 746 Query: 540 LT-GKKGYLAVDN 575 T GK+ + + N Sbjct: 747 FTYGKQPWYQLSN 759
>MYLK_RABIT (P29294) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] Length = 1147 Score = 72.4 bits (176), Expect = 1e-12 Identities = 46/143 (32%), Positives = 82/143 (57%), Gaps = 4/143 (2%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL- 356 ++ E + G L + I D ++ R+C + ++ I +G+ Y+H++ I+HLDLKP NI+ Sbjct: 767 VMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 826 Query: 357 --DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVI 527 G + K+ DFG++R S + + GT ++APE N E I+Y D++S+GVI Sbjct: 827 NKTGTRI-KLIDFGLARRLENAGSLKV---LFGTPEFVAPEVINYEPISYATDMWSIGVI 882 Query: 528 IIEILTGKKGYLAVDNVVESWSN 596 +++G ++ DN E+ +N Sbjct: 883 CYILVSGLSPFMG-DNDNETLAN 904
>IPL1_DEBHA (Q6BVA0) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 412 Score = 72.4 bits (176), Expect = 1e-12 Identities = 54/181 (29%), Positives = 83/181 (45%), Gaps = 2/181 (1%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 EK F R +E + H + R G+ D + L EY +G L Sbjct: 190 EKNFRREIEIQSNLIHPKISRLYGFFYDHKNVY----------------LILEYSIHGEL 233 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 ++ R+ I + L YLH ++I+H D+KP NILL + K++DFG Sbjct: 234 YHHLK-VQRRFNDATASHYIYQVALALDYLHTKHIIHRDIKPENILLSTDNCIKLSDFGW 292 Query: 396 S-RCFHEMQSRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTGKKGYLAV 569 S + ++ +T I GTL YL PE + E Y +DI+S+G++ E L GK + + Sbjct: 293 SVKSLPSSSTKRLT--ICGTLDYLPPEMIESNEHDYTVDIWSLGILCYEFLVGKPPFEEI 350 Query: 570 D 572 D Sbjct: 351 D 351
>MYLK_BOVIN (Q28824) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] Length = 1176 Score = 72.4 bits (176), Expect = 1e-12 Identities = 47/143 (32%), Positives = 81/143 (56%), Gaps = 4/143 (2%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL- 356 ++ E + G L + I D ++ R+C + +K I +G+ Y+H++ I+HLDLKP NI+ Sbjct: 796 VMVLEIVSGGELFERIIDEDFELTERECIKYMKQISEGVEYIHKQGIVHLDLKPENIMCV 855 Query: 357 --DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVI 527 G + K+ DFG++R S + + GT ++APE N E I Y D++S+GVI Sbjct: 856 NKTGTRI-KLIDFGLARRLENAGSLKV---LFGTPEFVAPEVINYEPIGYATDMWSIGVI 911 Query: 528 IIEILTGKKGYLAVDNVVESWSN 596 +++G ++ DN E+ +N Sbjct: 912 CYILVSGLSPFMG-DNDNETLAN 933
>CD2L7_HUMAN (Q9NYV4) Cell division cycle 2-related protein kinase 7 (EC| 2.7.11.22) (CDC2-related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) Length = 1490 Score = 72.4 bits (176), Expect = 1e-12 Identities = 53/172 (30%), Positives = 86/172 (50%), Gaps = 5/172 (2%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPN---GSLDK 221 R ++ L + H++VV D Q +++ K L FEY+ + G L+ Sbjct: 773 REIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAF------YLVFEYMDHDLMGLLES 826 Query: 222 YITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSR 401 + S +K + +GL Y H++N LH D+K +NILL+ + K+ADFG++R Sbjct: 827 GLVHFSED----HIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLAR 882 Query: 402 CFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTGK 551 ++ +SR T + TL Y PE GE Y +D++S G I+ E+ T K Sbjct: 883 LYNSEESRPYTNKVI-TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKK 933
>MYLK_SHEEP (O02827) Myosin light chain kinase, smooth muscle (EC 2.7.11.18)| (MLCK) [Contains: Telokin] (Fragment) Length = 438 Score = 72.4 bits (176), Expect = 1e-12 Identities = 47/143 (32%), Positives = 81/143 (56%), Gaps = 4/143 (2%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL- 356 ++ E + G L + I D ++ R+C + +K I +G+ Y+H++ I+HLDLKP NI+ Sbjct: 57 VMVLEIVSGGELFERIIDEDFELTERECIKYMKQISEGVEYIHKQGIVHLDLKPENIMCV 116 Query: 357 --DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVI 527 G + K+ DFG++R S + + GT ++APE N E I Y D++S+GVI Sbjct: 117 NKTGTRI-KLIDFGLARRLENAGSLKV---LFGTPEFVAPEVINYEPIGYATDMWSIGVI 172 Query: 528 IIEILTGKKGYLAVDNVVESWSN 596 +++G ++ DN E+ +N Sbjct: 173 CYILVSGLSPFMG-DNDNETLAN 194
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 72.4 bits (176), Expect = 1e-12 Identities = 52/196 (26%), Positives = 90/196 (45%), Gaps = 12/196 (6%) Frame = +3 Query: 24 THMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLP 203 T ++F + H N++R G V+ + ++ EY+ Sbjct: 34 TDKQRRDFLSEASIMGQFDHPNIIRLEG----------------VVTKCKPVMIITEYME 77 Query: 204 NGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIA 383 NGSLD ++ + + I++GI G+ YL + +H DL NIL++ NLV K++ Sbjct: 78 NGSLDAFLRKNDGRFTVIQLVGILRGIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVS 137 Query: 384 DFGVSRCFHEMQSRAITV-NIRGT---------LGYLAPE-FCNGEITYQLDIYSVGVII 530 DFG+SR E A T I GT + + APE + T D++S G+++ Sbjct: 138 DFGMSRVLEEDPDAAYTTREITGTYQSQGGKIPIRWTAPEAITYRKFTSASDVWSYGIVM 197 Query: 531 IEILT-GKKGYLAVDN 575 E+++ G++ Y + N Sbjct: 198 WEVMSYGERPYWDMSN 213
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 72.0 bits (175), Expect = 1e-12 Identities = 54/194 (27%), Positives = 91/194 (46%), Gaps = 3/194 (1%) Frame = +3 Query: 3 AVXXLSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRL 182 AV L M F + ++HK +VR + + + Sbjct: 270 AVKSLKQGSMSPDAFLAEANLMKQLQHKRLVRL-----------------YAVVTEEPIY 312 Query: 183 LCFEYLPNGSLDKYI-TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD 359 + EY+ NGSL ++ T + K+ K + I +G+ +L +RN +H DL+ ANIL+ Sbjct: 313 IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIVEGMAFLEERNYIHRDLRAANILVS 372 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVIIIE 536 L KIADFG++R + + A + + + APE N G T + D++S G+++ E Sbjct: 373 DTLSCKIADFGLARLIEDNEYTA-REGAKFPIKWTAPEAINYGTFTIKSDVWSFGILMTE 431 Query: 537 ILT-GKKGYLAVDN 575 I+T G+ Y + N Sbjct: 432 IVTHGRIPYPGMTN 445
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 72.0 bits (175), Expect = 1e-12 Identities = 46/171 (26%), Positives = 84/171 (49%), Gaps = 3/171 (1%) Frame = +3 Query: 42 EFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNG-KFVMADVQQRLLCFEYLPNGSLD 218 + + +E L + H+N+V++ G C + G NG K +M E+LP+GSL Sbjct: 909 DLKKEIEILRNLYHENIVKYKGICTEDGG-----NGIKLIM----------EFLPSGSLK 953 Query: 219 KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVS 398 +Y+ K+ ++ + IC+G+ YL R +H DL N+L++ KI DFG++ Sbjct: 954 EYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLT 1013 Query: 399 RCFH-EMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILT 545 + + + + + + + APE + D++S GV + E+LT Sbjct: 1014 KAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT 1064 Score = 33.9 bits (76), Expect = 0.43 Identities = 23/104 (22%), Positives = 45/104 (43%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F + V HK++V G C + DV + ++ E++ G LD + Sbjct: 623 FFEAASMMRQVSHKHIVYLYGVC---------------VRDV-ENIMVEEFVEGGPLDLF 666 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL 356 + S + F++ K + L YL ++++H ++ N+LL Sbjct: 667 MHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLL 710
>CLA4_ASHGO (Q9HFW2) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 793 Score = 72.0 bits (175), Expect = 1e-12 Identities = 52/169 (30%), Positives = 82/169 (48%), Gaps = 7/169 (4%) Frame = +3 Query: 78 KHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYI-----TDTSR 242 +HKN+V FL T+ + + EY+ GSL I +D S Sbjct: 569 QHKNIVNFLEAYLKTEDDL---------------WVVMEYMEGGSLTDVIENSIGSDASE 613 Query: 243 KVQWR-KCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQ 419 + I++ CQGL +LH ++I+H D+K N+LLD + KI DFG C Sbjct: 614 SPMTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTHGRVKITDFGF--CAKLTD 671 Query: 420 SRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTGKKGYL 563 R+ + GT ++APE E ++D++S+G++ IE+L G+ YL Sbjct: 672 KRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLEGEPPYL 720
>LIMK1_XENLA (O42565) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (xLIMK1)| Length = 615 Score = 71.6 bits (174), Expect = 2e-12 Identities = 49/177 (27%), Positives = 84/177 (47%), Gaps = 8/177 (4%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 ++ F + V+ + ++H +V++F+G V+ ++ EY+P G+L Sbjct: 353 QRTFLKEVKVMRCLEHPHVLKFIG----------------VLYKDKRLNFITEYIPGGTL 396 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL--DGNLVPKIADF 389 + I W + + I G+ YLH NI+H DL N L+ DG LV +A+F Sbjct: 397 RRVIKSMDTHCPWNQRVSFARDIAAGMTYLHSMNIIHRDLNSHNCLVREDGGLV--VANF 454 Query: 390 GVSRCFHE-----MQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEIL 542 G+SR E + R + G ++APE NG +D++S G++I EI+ Sbjct: 455 GLSRLIPEETRDLRKDRRKRYTVVGNPYWMAPEMINGRSYDESVDVFSFGIVICEII 511
>CHK1_CAEBR (Q61RA2) Serine/threonine-protein kinase chk-1 (EC 2.7.11.1)| Length = 493 Score = 71.2 bits (173), Expect = 2e-12 Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 5/187 (2%) Frame = +3 Query: 6 VXXLSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLL 185 + +NT+ KEF + L V H N +R +G M NG L Sbjct: 60 ITTQANTNNIRKEF-LIQQKLSKVGHDNFIRAIG--------MRTENGF--------HFL 102 Query: 186 CFEYLPNGSL-DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 EY G L DK D + + + + +GL Y+H +I+H D+KP N+LL Sbjct: 103 FLEYADGGELFDKIEPDHGMPTAIAQFY--FRQLIEGLKYIHDCDIVHRDIKPENLLLTT 160 Query: 363 NLVPKIADFGVSRCF-HEMQSRAITVNIRGTLGYLAPEFCNGEITYQ---LDIYSVGVII 530 + V KI+DFG++ + +E + R + ++ GT+ Y APE C G Y+ +D++S G+++ Sbjct: 161 SHVLKISDFGMATLYRNEGKERLLDLSC-GTIPYAAPEVCAGG-KYRGPPIDVWSSGIVL 218 Query: 531 IEILTGK 551 I +LTG+ Sbjct: 219 IAMLTGE 225
>CLA4_YEAST (P48562) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 842 Score = 71.2 bits (173), Expect = 2e-12 Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 7/172 (4%) Frame = +3 Query: 78 KHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDTSRK---- 245 +HKN+V FL T + + E++ GSL I ++ Sbjct: 618 RHKNIVNFLEAYLRTDDDL---------------WVVMEFMEGGSLTDIIENSPTNDNSH 662 Query: 246 --VQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQ 419 + + I++ CQGL +LH ++I+H D+K N+LLD KI DFG C Sbjct: 663 SPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGF--CARLTD 720 Query: 420 SRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTGKKGYLAVD 572 R+ + GT ++APE E ++D++S+G++ IE+L G+ YL D Sbjct: 721 KRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNED 772
>MYLK_HUMAN (Q15746) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin (Kinase-related protein) (KRP)] Length = 1914 Score = 71.2 bits (173), Expect = 2e-12 Identities = 46/143 (32%), Positives = 81/143 (56%), Gaps = 4/143 (2%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL- 356 ++ E + G L + I D ++ R+C + ++ I +G+ Y+H++ I+HLDLKP NI+ Sbjct: 1535 VMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 1594 Query: 357 --DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVI 527 G + K+ DFG++R S + + GT ++APE N E I Y D++S+GVI Sbjct: 1595 NKTGTRI-KLIDFGLARRLENAGSLKV---LFGTPEFVAPEVINYEPIGYATDMWSIGVI 1650 Query: 528 IIEILTGKKGYLAVDNVVESWSN 596 +++G ++ DN E+ +N Sbjct: 1651 CYILVSGLSPFMG-DNDNETLAN 1672
>MYLK_MOUSE (Q6PDN3) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin (Kinase-related protein) (KRP)] Length = 1941 Score = 71.2 bits (173), Expect = 2e-12 Identities = 46/143 (32%), Positives = 81/143 (56%), Gaps = 4/143 (2%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL- 356 ++ E + G L + I D ++ R+C + ++ I +G+ Y+H++ I+HLDLKP NI+ Sbjct: 1557 VMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV 1616 Query: 357 --DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVI 527 G + K+ DFG++R S + + GT ++APE N E I Y D++S+GVI Sbjct: 1617 NKTGTRI-KLIDFGLARRLENAGSLKV---LFGTPEFVAPEVINYEPIGYATDMWSIGVI 1672 Query: 528 IIEILTGKKGYLAVDNVVESWSN 596 +++G ++ DN E+ +N Sbjct: 1673 CYILVSGLSPFMG-DNDNETLAN 1694
>CDC22_XENLA (P24033) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 2) Length = 302 Score = 71.2 bits (173), Expect = 2e-12 Identities = 58/169 (34%), Positives = 85/169 (50%), Gaps = 2/169 (1%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R + L ++H N+V L Q S +F+ DV++ L + +P+G +YI Sbjct: 50 REISLLKELQHPNIVCLLDVLM--QDSRLYLIFEFLSMDVKKYL---DSIPSG---QYID 101 Query: 231 DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFH 410 K + I QG+ + H R +LH DLKP N+L+D V K+ADFG++R F Sbjct: 102 TMLVK-------SYLYQILQGIVFCHSRGVLHRDLKPQNLLIDNKGVIKLADFGLARAF- 153 Query: 411 EMQSRAITVNIRGTLGYLAPEFCNGEITYQ--LDIYSVGVIIIEILTGK 551 + R T + TL Y APE G + Y +D++SVG I EI T K Sbjct: 154 GIPVRVYTHEV-VTLWYRAPEVLLGSVRYSTPVDVWSVGTIFAEIATKK 201
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 71.2 bits (173), Expect = 2e-12 Identities = 44/131 (33%), Positives = 74/131 (56%), Gaps = 3/131 (2%) Frame = +3 Query: 192 EYLPNGSLDKYI-TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNL 368 E++ GSL ++ +D K K I +G+ ++ QRN +H DL+ ANIL+ +L Sbjct: 333 EFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASL 392 Query: 369 VPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVIIIEILT 545 V KIADFG++R + + A + + + APE N G T + D++S G++++EI+T Sbjct: 393 VCKIADFGLARVIEDNEYTA-REGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT 451 Query: 546 -GKKGYLAVDN 575 G+ Y + N Sbjct: 452 YGRIPYPGMSN 462
>CHK1_DROME (O61661) Serine/threonine-protein kinase grp (EC 2.7.11.1) (Protein| grapes) (Chk1 homolog) Length = 512 Score = 71.2 bits (173), Expect = 2e-12 Identities = 53/162 (32%), Positives = 80/162 (49%), Gaps = 2/162 (1%) Frame = +3 Query: 72 MVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL-DKYITDTSRKV 248 M++ K+++RF G +QGS+E + EY G L D+ D + Sbjct: 74 MLQDKHILRFFG--KRSQGSVE--------------YIFLEYAAGGELFDRIEPDVG--M 115 Query: 249 QWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSRA 428 + + + GL+YLHQR I H DLKP N+LLD + KI+DFG++ F Sbjct: 116 PQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKER 175 Query: 429 ITVNIRGTLGYLAPEFCNGEITYQ-LDIYSVGVIIIEILTGK 551 + GTL Y+APE Q D++S GVI++ +L G+ Sbjct: 176 LLDKRCGTLPYVAPEVLQKAYHAQPADLWSCGVILVTMLAGE 217
>CDK9_CHICK (Q5ZKN1) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 71.2 bits (173), Expect = 2e-12 Identities = 49/169 (28%), Positives = 84/169 (49%), Gaps = 4/169 (2%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R ++ L ++KH+NVV + C R G L F++ + L ++ Sbjct: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIY--------LVFDFCEH-DLAGLLS 115 Query: 231 DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFH 410 +T K + ++++ + GL+Y+H+ ILH D+K AN+L+ + V K+ADFG++R F Sbjct: 116 NTHVKFTLSEIKKVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFS 175 Query: 411 EMQSRAIT--VNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILT 545 ++ N TL Y PE GE Y +D++ G I+ E+ T Sbjct: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGGGCIMAEMWT 224
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 71.2 bits (173), Expect = 2e-12 Identities = 55/194 (28%), Positives = 92/194 (47%), Gaps = 3/194 (1%) Frame = +3 Query: 3 AVXXLSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRL 182 AV L M F + ++H+ +VR Y TQ + Sbjct: 270 AVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRL--YAVVTQEPI---------------Y 312 Query: 183 LCFEYLPNGSLDKYI-TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD 359 + EY+ NGSL ++ T + K+ K + I +G+ ++ +RN +H DL+ ANIL+ Sbjct: 313 IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS 372 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVIIIE 536 L KIADFG++R + + A + + + APE N G T + D++S G+++ E Sbjct: 373 DTLSCKIADFGLARLIEDNEYTA-REGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTE 431 Query: 537 ILT-GKKGYLAVDN 575 I+T G+ Y + N Sbjct: 432 IVTHGRIPYPGMTN 445
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 71.2 bits (173), Expect = 2e-12 Identities = 55/194 (28%), Positives = 92/194 (47%), Gaps = 3/194 (1%) Frame = +3 Query: 3 AVXXLSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRL 182 AV L M F + ++H+ +VR Y TQ + Sbjct: 270 AVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRL--YAVVTQEPI---------------Y 312 Query: 183 LCFEYLPNGSLDKYI-TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD 359 + EY+ NGSL ++ T + K+ K + I +G+ ++ +RN +H DL+ ANIL+ Sbjct: 313 IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS 372 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVIIIE 536 L KIADFG++R + + A + + + APE N G T + D++S G+++ E Sbjct: 373 DTLSCKIADFGLARLIEDNEYTA-REGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTE 431 Query: 537 ILT-GKKGYLAVDN 575 I+T G+ Y + N Sbjct: 432 IVTHGRIPYPGMTN 445
>KPCD_HUMAN (Q05655) Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta)| Length = 676 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/124 (37%), Positives = 71/124 (57%), Gaps = 1/124 (0%) Frame = +3 Query: 192 EYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLV 371 E+L G L +I D R +R F + +C GL +LH + I++ DLK N+LLD + Sbjct: 428 EFLNGGDLMYHIQDKGRFELYRATFYAAEIMC-GLQFLHSKGIIYRDLKLDNVLLDRDGH 486 Query: 372 PKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTG 548 KIADFG+ + +SRA T GT Y+APE G + T+ +D +S GV++ E+L G Sbjct: 487 IKIADFGMCKENIFGESRAST--FCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIG 544 Query: 549 KKGY 560 + + Sbjct: 545 QSPF 548
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/163 (28%), Positives = 85/163 (52%), Gaps = 1/163 (0%) Frame = +3 Query: 78 KHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDTSRKVQWR 257 +HKN+V FL +++ D + + EY+ GSL + I + K+ + Sbjct: 734 QHKNIVNFLD--------------SYLIGD-NELWVIMEYMQGGSLTEIIENNDFKLNEK 778 Query: 258 KCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSRAITV 437 + I +GL +LH+++I+H D+K N+LLD KI DFG + +++ T Sbjct: 779 QIATICFETLKGLQHLHKKHIIHRDIKSDNVLLDAYGNVKITDFGFCAKLTDQRNKRAT- 837 Query: 438 NIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTGKKGYL 563 + GT ++APE E ++D++S+G++ IE++ G+ YL Sbjct: 838 -MVGTPYWMAPEVVKQKEYDEKVDVWSLGIMTIEMIEGEPPYL 879
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 70.9 bits (172), Expect = 3e-12 Identities = 43/128 (33%), Positives = 77/128 (60%), Gaps = 5/128 (3%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD- 359 + EY+ +L +YIT + + ++ I++ I + + HQ I+H D+KP NIL+D Sbjct: 86 IVMEYVEGMTLKEYIT-ANGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDH 144 Query: 360 -GNLVPKIADFGVSRCFHEMQSRAI--TVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVI 527 GN+ K+ DFG++ + S I T ++ G++ YL+PE G + T + DIY++G++ Sbjct: 145 MGNI--KVTDFGIATA---LSSTTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIV 199 Query: 528 IIEILTGK 551 + E+LTG+ Sbjct: 200 LFELLTGR 207
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 70.9 bits (172), Expect = 3e-12 Identities = 53/173 (30%), Positives = 82/173 (47%), Gaps = 2/173 (1%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRL-LCFEYLPNGS 212 E + R +E +KH N+++ Y D QQR+ L EY P G Sbjct: 122 EHQLRREIEIQAHLKHPNILQLYNYFYD-----------------QQRIYLILEYAPRGE 164 Query: 213 LDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFG 392 L K + + + R I++ + L Y H++ ++H D+KP N+LL KIADFG Sbjct: 165 LYKELQKSGTFDEQRTA-TIMEELSDALMYCHKKKVIHRDIKPENLLLGLQGELKIADFG 223 Query: 393 VSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQL-DIYSVGVIIIEILTG 548 S H R T + GTL YL PE G + ++ D++ +GV+ E++ G Sbjct: 224 WS--VHAPSLRRKT--MCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVG 272
>DAPK3_RAT (O88764) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 70.9 bits (172), Expect = 3e-12 Identities = 52/180 (28%), Positives = 86/180 (47%), Gaps = 5/180 (2%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 +E R V L ++H N++ V + +L E + G L Sbjct: 59 EEIEREVSILREIRHPNIITLHD----------------VFENKTDVVLILELVSGGELF 102 Query: 219 KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANI-LLDGNLVP---KIAD 386 ++ + + + Q +K I G+HYLH + I H DLKP NI LLD + K+ D Sbjct: 103 DFLAEKESLTE-DEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKHAASPRIKLID 161 Query: 387 FGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYL 563 FG++ H +++ + NI GT ++APE N E + + D++S+GVI +L+G +L Sbjct: 162 FGIA---HRIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFL 218
>DAPK3_MOUSE (O54784) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 70.9 bits (172), Expect = 3e-12 Identities = 52/180 (28%), Positives = 86/180 (47%), Gaps = 5/180 (2%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 +E R V L ++H N++ V + +L E + G L Sbjct: 59 EEIEREVSILREIRHPNIITLHD----------------VFENKTDVVLILELVSGGELF 102 Query: 219 KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANI-LLDGNLVP---KIAD 386 ++ + + + Q +K I G+HYLH + I H DLKP NI LLD + K+ D Sbjct: 103 DFLAEKESLTE-DEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKHAASPRIKLID 161 Query: 387 FGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYL 563 FG++ H +++ + NI GT ++APE N E + + D++S+GVI +L+G +L Sbjct: 162 FGIA---HRIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFL 218
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 70.9 bits (172), Expect = 3e-12 Identities = 43/137 (31%), Positives = 76/137 (55%), Gaps = 5/137 (3%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD 359 ++ EY+ NGSLD ++ + + +++GI G+ YL + N +H DL NIL++ Sbjct: 701 MIVTEYMENGSLDTFLKKHDGQFTVIQLLGMLRGIAAGMQYLSEMNYVHRDLAARNILVN 760 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRG---TLGYLAPE-FCNGEITYQLDIYSVGVI 527 NLV K++DFG+SR + A T RG + + APE + T D++S G++ Sbjct: 761 RNLVCKVSDFGLSRVLEDDPEAAYTT--RGGKIPIRWTAPEAITYRKFTSASDVWSYGIV 818 Query: 528 IIEILT-GKKGYLAVDN 575 + E+++ G++ Y + N Sbjct: 819 MWEVISYGERPYWEMSN 835
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 70.9 bits (172), Expect = 3e-12 Identities = 49/193 (25%), Positives = 95/193 (49%), Gaps = 2/193 (1%) Frame = +3 Query: 3 AVXXLSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRL 182 AV + M E EF + + +M + H +V+F G C+ ++Y V Sbjct: 419 AVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCS------KKYPIYIVT------- 465 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 EY+ NG L Y+ + ++ + ++ +C+G+ +L +H DL N L+D Sbjct: 466 ---EYITNGCLLNYLKSHGKGLESCQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDS 522 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEI 539 +L K++DFG++R + Q +V + + + APE F + + + D+++ G+++ E+ Sbjct: 523 DLSVKVSDFGMTRYVLDDQ-YVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEV 581 Query: 540 LT-GKKGYLAVDN 575 + GK+ Y DN Sbjct: 582 FSLGKQPYDLYDN 594
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 70.9 bits (172), Expect = 3e-12 Identities = 48/189 (25%), Positives = 89/189 (47%), Gaps = 5/189 (2%) Frame = +3 Query: 24 THMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLP 203 T ++F + H N++R G V+ + ++ EY+ Sbjct: 660 TEKQRRDFLGEASIMGQFDHPNIIRLEG----------------VVTKSKPEMIVTEYME 703 Query: 204 NGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIA 383 NGSLD ++ + + +++GI G+ YL +H DL NIL++ NLV K++ Sbjct: 704 NGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVS 763 Query: 384 DFGVSRCFHEMQSRAITVNIRG---TLGYLAPEFCN-GEITYQLDIYSVGVIIIEILT-G 548 DFG+SR + A T RG + + +PE + + T D++S G+++ E+++ G Sbjct: 764 DFGLSRVLEDDPEAAYTT--RGGKIPIRWTSPEAMSYRKFTSASDVWSYGIVLWEVMSYG 821 Query: 549 KKGYLAVDN 575 ++ Y + N Sbjct: 822 ERPYSQMSN 830
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 70.9 bits (172), Expect = 3e-12 Identities = 42/172 (24%), Positives = 94/172 (54%), Gaps = 3/172 (1%) Frame = +3 Query: 81 HKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDTSRKVQWRK 260 H N+V++LG+ + D+ + EY+ GS+ + + + + Sbjct: 889 HLNIVQYLGF-------------EKTETDIS---IFLEYVSGGSIGRCLRNYGPFEEQLV 932 Query: 261 CFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSRAITVN 440 F + + + GL YLH + I+H DLK N+L+D + V KI+DFG+S+ + ++ Sbjct: 933 RF-VSRQVLYGLSYLHSKGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANLS 991 Query: 441 IRGTLGYLAPEFCNGE---ITYQLDIYSVGVIIIEILTGKKGYLAVDNVVES 587 ++G++ ++APE + + + ++D++S+G +++E+L G++ + + D +++ Sbjct: 992 MQGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRRPW-STDEAIQA 1042
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/172 (27%), Positives = 87/172 (50%), Gaps = 4/172 (2%) Frame = +3 Query: 42 EFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNG-KFVMADVQQRLLCFEYLPNGSLD 218 + + +E L + H+N+V++ G C + G NG K +M E+LP+GSL Sbjct: 920 DLKKEIEILRNLYHENIVKYKGICMEDGG-----NGIKLIM----------EFLPSGSLK 964 Query: 219 KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVS 398 +Y+ K+ ++ + IC+G+ YL R +H DL N+L++ KI DFG++ Sbjct: 965 EYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLT 1024 Query: 399 RCFH-EMQSRAITVNIRGTLGYLAPEFCNGEITYQL--DIYSVGVIIIEILT 545 + + + + + + + APE C + + + D++S GV + E+LT Sbjct: 1025 KAIETDKEYYTVKDDRDSPVFWYAPE-CLIQCKFYIASDVWSFGVTLHELLT 1075 Score = 35.4 bits (80), Expect = 0.15 Identities = 28/124 (22%), Positives = 55/124 (44%), Gaps = 7/124 (5%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F + V HK++V G C + DV + ++ E++ G LD + Sbjct: 634 FFEAASMMRQVSHKHIVYLYGVC---------------VRDV-ENIMVEEFVEGGPLDLF 677 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL-----DGNLVP--KIA 383 + S + F++ K + L YL ++++H ++ N+LL D ++ P K++ Sbjct: 678 MHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLS 737 Query: 384 DFGV 395 D G+ Sbjct: 738 DPGI 741
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 70.5 bits (171), Expect = 4e-12 Identities = 54/187 (28%), Positives = 88/187 (47%), Gaps = 14/187 (7%) Frame = +3 Query: 42 EFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDK 221 EF + H NV+R +G V+ + ++ EY+ NGSLD+ Sbjct: 761 EFLTEATIMGQFSHPNVIRLIG----------------VVTSAEPVMIVAEYMANGSLDQ 804 Query: 222 YITDTSR---KVQWRKCFQIIKGICQGLHYLHQRNILHL-----DLKPANILLDGNLVPK 377 ++ +T + KV W K +++ GI G+ YL +H DL N+LLD L K Sbjct: 805 FLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRVSFLRDLAARNVLLDMELRCK 864 Query: 378 IADFGVSRCFH----EMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEIL 542 IADFG+SR ++ T + + + APE + + T D++S GV+I E+ Sbjct: 865 IADFGLSRGVRSEGSSVEPEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVC 924 Query: 543 T-GKKGY 560 + G++ Y Sbjct: 925 SFGERPY 931
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 70.5 bits (171), Expect = 4e-12 Identities = 49/193 (25%), Positives = 94/193 (48%), Gaps = 2/193 (1%) Frame = +3 Query: 3 AVXXLSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRL 182 AV + M E EF + + +M + H +V+F G C+ + Y V Sbjct: 443 AVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS------KEYPIYIVT------- 489 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 EY+ NG L Y+ + ++ + ++ +C+G+ +L +H DL N L+D Sbjct: 490 ---EYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDR 546 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEI 539 +L K++DFG++R + Q +V + + + APE F + + + D+++ G+++ E+ Sbjct: 547 DLCVKVSDFGMTRYVLDDQ-YVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEV 605 Query: 540 LT-GKKGYLAVDN 575 + GK+ Y DN Sbjct: 606 FSLGKQPYDLYDN 618
>DAPK2_HUMAN (Q9UIK4) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 70.5 bits (171), Expect = 4e-12 Identities = 58/191 (30%), Positives = 90/191 (47%), Gaps = 5/191 (2%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 +E R V L V H NV+ + Y + DV +L E + G L Sbjct: 69 EEIEREVSILRQVLHHNVITL----------HDVYENR---TDV---VLILELVSGGELF 112 Query: 219 KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVP----KIAD 386 ++ + + IK I G++YLH + I H DLKP NI+L +P K+ D Sbjct: 113 DFLAQ-KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLID 171 Query: 387 FGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYL 563 FG++ HE++ NI GT ++APE N E + + D++S+GVI +L+G +L Sbjct: 172 FGLA---HEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFL 228 Query: 564 AVDNVVESWSN 596 D E+ +N Sbjct: 229 G-DTKQETLAN 238
>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a) Length = 692 Score = 70.5 bits (171), Expect = 4e-12 Identities = 42/134 (31%), Positives = 73/134 (54%), Gaps = 3/134 (2%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKV-QWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL 356 ++ EY P G+L ++I + + I LH++H ILH DLK NILL Sbjct: 77 MIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILL 136 Query: 357 DGN-LVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVII 530 D + +V KI DFG+S+ + S++ + GT Y++PE C G+ + DI+++G ++ Sbjct: 137 DKHRMVVKIGDFGISKI---LSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVL 193 Query: 531 IEILTGKKGYLAVD 572 E+ + K+ + A + Sbjct: 194 YELASLKRAFEAAN 207
>LRRK2_MOUSE (Q5S006) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 2527 Score = 70.5 bits (171), Expect = 4e-12 Identities = 43/135 (31%), Positives = 69/135 (51%), Gaps = 7/135 (5%) Frame = +3 Query: 162 ADVQQRLLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKP 341 A ++ R+L E GSLD+ + + +I + GL YLH I++ DLKP Sbjct: 1938 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKP 1997 Query: 342 ANILL-----DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--Q 500 N+LL + ++ KIAD+G+++ M + GT G+ APE G + Y Q Sbjct: 1998 HNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIK----TSEGTPGFRAPEVARGNVIYNQQ 2053 Query: 501 LDIYSVGVIIIEILT 545 D+YS G+++ +I T Sbjct: 2054 ADVYSFGLLLHDIWT 2068
>HCK_MACFA (Q95M30) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 503 Score = 70.5 bits (171), Expect = 4e-12 Identities = 44/131 (33%), Positives = 74/131 (56%), Gaps = 3/131 (2%) Frame = +3 Query: 192 EYLPNGSLDKYI-TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNL 368 E++ GSL ++ +D K K I +G+ ++ QRN +H DL+ ANIL+ +L Sbjct: 311 EFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASL 370 Query: 369 VPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVIIIEILT 545 V KIADFG++R + + A + + + APE N G T + D++S G++++EI+T Sbjct: 371 VCKIADFGLARIIEDNEYTA-REGAKFPIKWTAPEAINFGSSTIKSDVWSFGILLMEIVT 429 Query: 546 -GKKGYLAVDN 575 G+ Y + N Sbjct: 430 YGRIPYPGMSN 440
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 70.5 bits (171), Expect = 4e-12 Identities = 53/142 (37%), Positives = 76/142 (53%), Gaps = 11/142 (7%) Frame = +3 Query: 192 EYLPNGSLDKYITDTSR--KVQWRKCFQIIKGICQGLHYLHQRN--ILHLDLKPANILLD 359 EY+PNGSL++ + + V W F+I+ I G++YLH +LH DLK NILLD Sbjct: 96 EYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLD 155 Query: 360 GNLVPKIADFGVS--RCFHEMQSRAI-TVNIRGTLGYLAPEFC----NGEITYQLDIYSV 518 KIADFG+S R QSR+ + GT+ Y+ PE + + DIYS Sbjct: 156 NEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSY 215 Query: 519 GVIIIEILTGKKGYLAVDNVVE 584 VI E+L+ K+ + V N ++ Sbjct: 216 AVITWEVLSRKQPFEDVTNPLQ 237
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 70.5 bits (171), Expect = 4e-12 Identities = 49/186 (26%), Positives = 89/186 (47%), Gaps = 6/186 (3%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL 215 +++F R +E + +KH+N+V LG V+ + + + FEY+ NG L Sbjct: 453 QQDFKREIELISDLKHQNIVCILG----------------VVLNKEPYCMLFEYMANGDL 496 Query: 216 DKYITDTS----RKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIA 383 +++ S + + + QI I +G+ YL + +H DL N L++ LV KI+ Sbjct: 497 HEFLISNSPTEGKSLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKIS 556 Query: 384 DFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILT-GKKG 557 DFG+SR + + + ++ E G+ T + D++S GV++ EI + G + Sbjct: 557 DFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQP 616 Query: 558 YLAVDN 575 Y N Sbjct: 617 YYGFSN 622
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 70.5 bits (171), Expect = 4e-12 Identities = 50/196 (25%), Positives = 88/196 (44%), Gaps = 17/196 (8%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K+F R E L ++H+++V+F G C D ++ FEY+ +G L+ Sbjct: 585 KDFQREAELLTNLQHEHIVKFYGVCGDGD----------------PLIMVFEYMKHGDLN 628 Query: 219 KYIT---------------DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL 353 K++ ++ + I I G+ YL ++ +H DL N L Sbjct: 629 KFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCL 688 Query: 354 LDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVII 530 + NL+ KI DFG+SR + + + + ++ PE + T + D++S GVI+ Sbjct: 689 VGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVIL 748 Query: 531 IEILT-GKKGYLAVDN 575 EI T GK+ + + N Sbjct: 749 WEIFTYGKQPWFQLSN 764
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 70.5 bits (171), Expect = 4e-12 Identities = 54/171 (31%), Positives = 82/171 (47%), Gaps = 4/171 (2%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R + L ++H N+V L V+ + L FE+L + L KY+ Sbjct: 50 REISLLKELQHPNIVCLLD----------------VLMQDSRLYLIFEFL-SMDLKKYLD 92 Query: 231 D--TSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + + + + I QG+ + H R +LH DLKP N+L+D V K+ADFG++R Sbjct: 93 SIPSGQYIDTMLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDSKGVIKLADFGLARA 152 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ--LDIYSVGVIIIEILTGK 551 F + R T + TL Y APE G + Y +D++S+G I EI T K Sbjct: 153 F-GIPVRVYTHEV-VTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIATKK 201
>CHK1_XENLA (Q6DE87) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (xChk1| protein) Length = 474 Score = 70.5 bits (171), Expect = 4e-12 Identities = 52/183 (28%), Positives = 84/183 (45%), Gaps = 3/183 (1%) Frame = +3 Query: 72 MVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL-DKYITDTSRKV 248 M+ H N+VRF G+ R G + L EY G L D+ D Sbjct: 61 MLSHTNIVRFYGH---------RREGNI-------QYLFLEYCRGGELFDRIEPDVGMPE 104 Query: 249 QWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSRA 428 Q + F + + G+ YLH I H D+KP N+LLD KI+DFG++ F Sbjct: 105 QDAQKF--FQQLIAGVEYLHSIGITHRDIKPENLLLDERDQLKISDFGLATVFRHNGKER 162 Query: 429 ITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTGKKGYLAVDNVVESWSNKL 602 + + GTL Y+APE + +D++S G+++ +L G+ + + V + + + Sbjct: 163 LLNKMCGTLPYVAPELIKSRAFHADPVDVWSCGIVLTAMLAGELPWDQPNEVCQEYCDWK 222 Query: 603 EKS 611 EK+ Sbjct: 223 EKN 225
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 70.5 bits (171), Expect = 4e-12 Identities = 48/189 (25%), Positives = 87/189 (46%), Gaps = 5/189 (2%) Frame = +3 Query: 24 THMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLP 203 T +EF + +H NV+ G V+ + ++ E++ Sbjct: 676 TDEQRREFLSEASIMGQFEHPNVIHLEG----------------VVTKSRPVMIVTEFME 719 Query: 204 NGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIA 383 NGSLD ++ + + +++GI G+ YL N +H DL NIL++ NLV K++ Sbjct: 720 NGSLDSFLRQKEGQFSVLQLVGMLRGIAAGMRYLSDMNYVHRDLAARNILVNSNLVCKVS 779 Query: 384 DFGVSRCFHEMQSRAITVNIRG---TLGYLAPEFCN-GEITYQLDIYSVGVIIIEILT-G 548 DFG+SR + S G + + APE + T D++S G+++ E+++ G Sbjct: 780 DFGLSRFLEDDASNPTYTGALGCKIPIRWTAPEAVQYRKFTSSSDVWSYGIVMWEVMSYG 839 Query: 549 KKGYLAVDN 575 ++ Y + N Sbjct: 840 ERPYWDMSN 848
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 70.5 bits (171), Expect = 4e-12 Identities = 50/196 (25%), Positives = 88/196 (44%), Gaps = 17/196 (8%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K+F R E L ++H+++V+F G C D ++ FEY+ +G L+ Sbjct: 583 KDFQREAELLTNLQHEHIVKFYGVCGDGD----------------PLIMVFEYMKHGDLN 626 Query: 219 KYIT---------------DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL 353 K++ ++ + I I G+ YL ++ +H DL N L Sbjct: 627 KFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCL 686 Query: 354 LDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVII 530 + NL+ KI DFG+SR + + + + ++ PE + T + D++S GVI+ Sbjct: 687 VGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVIL 746 Query: 531 IEILT-GKKGYLAVDN 575 EI T GK+ + + N Sbjct: 747 WEIFTYGKQPWFQLSN 762
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 70.5 bits (171), Expect = 4e-12 Identities = 50/196 (25%), Positives = 88/196 (44%), Gaps = 17/196 (8%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K+F R E L ++H+++V+F G C D ++ FEY+ +G L+ Sbjct: 583 KDFQREAELLTNLQHEHIVKFYGVCGDGD----------------PLIMVFEYMKHGDLN 626 Query: 219 KYIT---------------DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL 353 K++ ++ + I I G+ YL ++ +H DL N L Sbjct: 627 KFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCL 686 Query: 354 LDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVII 530 + NL+ KI DFG+SR + + + + ++ PE + T + D++S GVI+ Sbjct: 687 VGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVIL 746 Query: 531 IEILT-GKKGYLAVDN 575 EI T GK+ + + N Sbjct: 747 WEIFTYGKQPWFQLSN 762
>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) Length = 698 Score = 70.5 bits (171), Expect = 4e-12 Identities = 42/134 (31%), Positives = 73/134 (54%), Gaps = 3/134 (2%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKV-QWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL 356 ++ EY P G+L ++I + + I LH++H ILH DLK NILL Sbjct: 77 MIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILL 136 Query: 357 DGN-LVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVII 530 D + +V KI DFG+S+ + S++ + GT Y++PE C G+ + DI+++G ++ Sbjct: 137 DKHRMVVKIGDFGISKI---LSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVL 193 Query: 531 IEILTGKKGYLAVD 572 E+ + K+ + A + Sbjct: 194 YELASLKRAFEAAN 207
>PHKG2_RAT (P31325) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 70.5 bits (171), Expect = 4e-12 Identities = 44/129 (34%), Positives = 75/129 (58%), Gaps = 7/129 (5%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 L F+ + G L Y+T+ + ++ I++ + + +++LH NI+H DLKP NILLD Sbjct: 105 LVFDLMRKGELFDYLTEKVALSE-KETRSIMRSLLEAVNFLHVNNIVHRDLKPENILLDD 163 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEF--CNGEITY-----QLDIYSVG 521 N+ +++DFG S C E + + GT GYLAPE C+ + T+ ++D+++ G Sbjct: 164 NMQIRLSDFGFS-CHLEPGEK--LRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACG 220 Query: 522 VIIIEILTG 548 VI+ +L G Sbjct: 221 VILFTLLAG 229
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 70.5 bits (171), Expect = 4e-12 Identities = 44/129 (34%), Positives = 74/129 (57%), Gaps = 7/129 (5%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 L F+ + G L Y+T+ + ++ I++ + + + +LH NI+H DLKP NILLD Sbjct: 105 LVFDLMRKGELFDYLTEKVALSE-KETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDD 163 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEF--CNGEITY-----QLDIYSVG 521 N+ +++DFG S C E + + GT GYLAPE C+ + T+ ++D+++ G Sbjct: 164 NMQIRLSDFGFS-CHLEAGEK--LRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACG 220 Query: 522 VIIIEILTG 548 VI+ +L G Sbjct: 221 VILFTLLAG 229
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 70.5 bits (171), Expect = 4e-12 Identities = 49/188 (26%), Positives = 90/188 (47%), Gaps = 5/188 (2%) Frame = +3 Query: 42 EFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDK 221 + + E L ++ H+N+++F G V+ + + EY GSL Sbjct: 49 KIEKEAEILSVLSHRNIIQFYG----------------VILEPPNYGIVTEYASLGSLYD 92 Query: 222 YI-TDTSRKVQWRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLVPKIADF 389 YI ++ S ++ + +G+HYLH ++H DLK N+++ + V KI DF Sbjct: 93 YINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDF 152 Query: 390 GVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTGKKGYLA 566 G SR FH + +++ GT ++APE ++ D YS GV++ E+LT + + Sbjct: 153 GASR-FH---NHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKG 208 Query: 567 VDNVVESW 590 ++ + +W Sbjct: 209 LEGLQVAW 216
>CDC5_YEAST (P32562) Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC| 2.7.11.21) Length = 705 Score = 70.5 bits (171), Expect = 4e-12 Identities = 47/134 (35%), Positives = 69/134 (51%), Gaps = 4/134 (2%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKG-ICQGLHYLHQRNILHLDLKPANILLD 359 + E PNGSL + + RKV + IC + Y+H R ++H DLK NI D Sbjct: 156 ILLEICPNGSLMELLK--RRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFD 213 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE---ITYQLDIYSVGVII 530 N KI DFG++ R T I GT Y+APE G+ ++++DI+S+GV++ Sbjct: 214 SNYNLKIGDFGLAAVLANESERKYT--ICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVML 271 Query: 531 IEILTGKKGYLAVD 572 +L GK + A D Sbjct: 272 YALLIGKPPFQARD 285
>DAPK2_MOUSE (Q8VDF3) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 70.1 bits (170), Expect = 5e-12 Identities = 57/191 (29%), Positives = 90/191 (47%), Gaps = 5/191 (2%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 +E R V L V H N++ + Y + DV +L E + G L Sbjct: 69 EEIEREVSILRQVLHPNIITL----------HDVYENR---TDV---VLILELVSGGELF 112 Query: 219 KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVP----KIAD 386 ++ + + IK I G++YLH + I H DLKP NI+L +P K+ D Sbjct: 113 DFLAQ-KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLID 171 Query: 387 FGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYL 563 FG++ HE++ NI GT ++APE N E + + D++S+GVI +L+G +L Sbjct: 172 FGLA---HEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFL 228 Query: 564 AVDNVVESWSN 596 D E+ +N Sbjct: 229 G-DTKQETLAN 238
>CC2H3_TRYBB (P54666) Cell division control protein 2 homolog 3 (EC 2.7.11.22)| Length = 311 Score = 70.1 bits (170), Expect = 5e-12 Identities = 58/170 (34%), Positives = 81/170 (47%), Gaps = 3/170 (1%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGY-CADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYI 227 R V L + H N+V L CAD GK L FEY+ + L K + Sbjct: 69 REVSILQEIHHPNIVNLLDVICAD---------GKLY--------LIFEYVDH-DLKKAL 110 Query: 228 TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCF 407 +II + +GL + H+ I+H DLKPANIL+ + KIADFG++R F Sbjct: 111 EKRGGAFTGTTLKKIIYQLLEGLSFCHRHRIVHRDLKPANILVTTDNSVKIADFGLARAF 170 Query: 408 HEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTGK 551 ++ T + TL Y APE GE Y +D++S+G I E+ GK Sbjct: 171 -QIPMHTYTHEV-VTLWYRAPEILLGEKHYTPAVDMWSIGCIFAELARGK 218
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 70.1 bits (170), Expect = 5e-12 Identities = 51/173 (29%), Positives = 84/173 (48%), Gaps = 5/173 (2%) Frame = +3 Query: 42 EFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDK 221 EF R V + ++H N+V F+G + + EYL GSL + Sbjct: 592 EFLREVAIMKRLRHPNIVLFMG----------------AVTQPPNLSIVTEYLSRGSLYR 635 Query: 222 YITDTSRKVQW--RKCFQIIKGICQGLHYLHQRN--ILHLDLKPANILLDGNLVPKIADF 389 + + + Q R+ + + +G++YLH RN I+H DLK N+L+D K+ DF Sbjct: 636 LLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDF 695 Query: 390 GVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ-LDIYSVGVIIIEILT 545 G+SR + + + + GT ++APE E + + D+YS GVI+ E+ T Sbjct: 696 GLSRL--KASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELAT 746
>KIN11_ARATH (P92958) SNF1-related protein kinase catalytic alpha subunit KIN11| (EC 2.7.11.1) (AKIN11) (AKIN alpha1) Length = 512 Score = 70.1 bits (170), Expect = 5e-12 Identities = 52/180 (28%), Positives = 87/180 (48%), Gaps = 2/180 (1%) Frame = +3 Query: 15 LSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFE 194 + N M EK R ++ L + H +++R +Y +D+ + E Sbjct: 56 IKNMEMEEK-VRREIKILRLFMHPHIIR-------------QYEVIETTSDIY---VVME 98 Query: 195 YLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVP 374 Y+ +G L YI + R +Q + + I G+ Y H+ ++H DLKP N+LLD Sbjct: 99 YVKSGELFDYIVEKGR-LQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSRCNI 157 Query: 375 KIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTG 548 KIADFG+S + M+ G+ Y APE +G++ ++D++S GVI+ +L G Sbjct: 158 KIADFGLS---NVMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCG 214
>IKKA_MOUSE (Q60680) Inhibitor of nuclear factor kappa-B kinase alpha subunit| (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor N Length = 745 Score = 70.1 bits (170), Expect = 5e-12 Identities = 51/175 (29%), Positives = 84/175 (48%), Gaps = 6/175 (3%) Frame = +3 Query: 57 VECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDT 236 ++ + + H NVV+ D + F++ DV LL EY G L K + Sbjct: 62 IQIMKKLDHANVVK----ACDVPEELN-----FLINDVP--LLAMEYCSGGDLRKLLNKP 110 Query: 237 SR--KVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD---GNLVPKIADFGVSR 401 ++ + ++ I G+ YLH+ I+H DLKP NI+L G + KI D G ++ Sbjct: 111 ENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKTIHKIIDLGYAK 170 Query: 402 CFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILTGKKGYL 563 ++ ++ + GTL YLAPE F N T +D +S G ++ E + G + +L Sbjct: 171 ---DVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFL 222
>IKKA_HUMAN (O15111) Inhibitor of nuclear factor kappa-B kinase alpha subunit| (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor N Length = 745 Score = 70.1 bits (170), Expect = 5e-12 Identities = 43/134 (32%), Positives = 69/134 (51%), Gaps = 6/134 (4%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSR--KVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL 353 LL EY G L K + ++ + ++ I G+ YLH+ I+H DLKP NI+ Sbjct: 92 LLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIV 151 Query: 354 LD---GNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVG 521 L G ++ KI D G ++ ++ ++ + GTL YLAPE F N T +D +S G Sbjct: 152 LQDVGGKIIHKIIDLGYAK---DVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFG 208 Query: 522 VIIIEILTGKKGYL 563 ++ E + G + +L Sbjct: 209 TMVFECIAGYRPFL 222
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 70.1 bits (170), Expect = 5e-12 Identities = 47/189 (24%), Positives = 90/189 (47%), Gaps = 5/189 (2%) Frame = +3 Query: 24 THMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLP 203 T ++F + H N++R G V+ + ++ E++ Sbjct: 648 TEQQRRDFLGEASIMGQFDHPNIIRLEG----------------VVTRSRPVMILTEFME 691 Query: 204 NGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIA 383 NG+LD ++ + + I++GI G+ YL + N +H DL NIL++ NLV K++ Sbjct: 692 NGALDSFLRMNDGQFTVIQLVGILRGIASGMKYLSEMNYVHRDLAARNILVNSNLVCKVS 751 Query: 384 DFGVSRCFHEMQSRAITVNIRG---TLGYLAPEFCN-GEITYQLDIYSVGVIIIEILT-G 548 DFG+SR +S + G + + APE + + T D++S G+++ E+++ G Sbjct: 752 DFGLSRFLENSRSDPTYTSALGGKIPIRWTAPEAISYRKFTSASDVWSYGIVMWEVMSYG 811 Query: 549 KKGYLAVDN 575 ++ Y + N Sbjct: 812 ERPYWDMSN 820
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 70.1 bits (170), Expect = 5e-12 Identities = 50/174 (28%), Positives = 84/174 (48%), Gaps = 4/174 (2%) Frame = +3 Query: 36 EKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCF--EYLPNG 209 E++F V L + H N+V+F+ C + + C EY+ G Sbjct: 129 EQQFKSEVALLSRLFHPNIVQFIAACK------------------KPPVYCIITEYMSQG 170 Query: 210 SLDKYITDTSR-KVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIAD 386 +L Y+ + ++ I +G+ YLH + ++H DLK N+LL+ + K+AD Sbjct: 171 NLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQGVIHRDLKSNNLLLNDEMRVKVAD 230 Query: 387 FGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILT 545 FG S C E Q R N+ GT ++APE + T ++D+YS G+++ E+ T Sbjct: 231 FGTS-CL-ETQCREAKGNM-GTYRWMAPEMIKEKPYTRKVDVYSFGIVLWELTT 281
>PHKG2_HUMAN (P15735) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3) Length = 406 Score = 70.1 bits (170), Expect = 5e-12 Identities = 44/129 (34%), Positives = 74/129 (57%), Gaps = 7/129 (5%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 L F+ + G L Y+T+ + ++ I++ + + + +LH NI+H DLKP NILLD Sbjct: 105 LVFDLMRKGELFDYLTEKVALSE-KETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDD 163 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEF--CNGEITY-----QLDIYSVG 521 N+ +++DFG S C E + + GT GYLAPE C+ + T+ ++D+++ G Sbjct: 164 NMQIRLSDFGFS-CHLEPGEK--LRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACG 220 Query: 522 VIIIEILTG 548 VI+ +L G Sbjct: 221 VILFTLLAG 229
>KIN10_ARATH (Q38997) SNF1-related protein kinase catalytic alpha subunit KIN10| (EC 2.7.11.1) (AKIN10) (AKIN alpha2) Length = 535 Score = 70.1 bits (170), Expect = 5e-12 Identities = 52/180 (28%), Positives = 83/180 (46%), Gaps = 2/180 (1%) Frame = +3 Query: 15 LSNTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFE 194 + N M EK R ++ L + H +++R V+ L E Sbjct: 78 IKNMEMEEK-VRREIKILRLFMHPHIIRLYE----------------VIETPTDIYLVME 120 Query: 195 YLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVP 374 Y+ +G L YI + R +Q + + I G+ Y H+ ++H DLKP N+LLD Sbjct: 121 YVNSGELFDYIVEKGR-LQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKCNV 179 Query: 375 KIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTG 548 KIADFG+S M+ G+ Y APE +G++ ++D++S GVI+ +L G Sbjct: 180 KIADFGLSNI---MRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCG 236
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 70.1 bits (170), Expect = 5e-12 Identities = 51/187 (27%), Positives = 87/187 (46%), Gaps = 3/187 (1%) Frame = +3 Query: 24 THMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLP 203 T ++F R + H N++R G T+G + ++ EY+ Sbjct: 41 TERQRQDFLREAAIMGQFDHPNIIRLEGVV--TRGRLA--------------MIVTEYME 84 Query: 204 NGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIA 383 NGSLD ++ + + ++KG+ G+ YL +H DL NIL+DG LV K++ Sbjct: 85 NGSLDAFLRTHDGQFTILQLVGMLKGVGAGMRYLSDLGYIHRDLAARNILVDGRLVCKVS 144 Query: 384 DFGVSRCFHEMQSRA-ITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILT-GKK 554 DFG+SR + A T + + + APE + D++S GV++ E+L G++ Sbjct: 145 DFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGER 204 Query: 555 GYLAVDN 575 Y + N Sbjct: 205 PYWNMTN 211
>CDK9_RAT (Q641Z4) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 70.1 bits (170), Expect = 5e-12 Identities = 48/169 (28%), Positives = 83/169 (49%), Gaps = 4/169 (2%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R ++ L ++KH+NVV + C R G L F++ + L ++ Sbjct: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIY--------LVFDFCEH-DLAGLLS 115 Query: 231 DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFH 410 + K + ++++ + GL+Y+H+ ILH D+K AN+L+ + V K+ADFG++R F Sbjct: 116 NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFS 175 Query: 411 EMQSRAIT--VNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILT 545 ++ N TL Y PE GE Y +D++ G I+ E+ T Sbjct: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224
>CDK9_MOUSE (Q99J95) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 70.1 bits (170), Expect = 5e-12 Identities = 48/169 (28%), Positives = 83/169 (49%), Gaps = 4/169 (2%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R ++ L ++KH+NVV + C R G L F++ + L ++ Sbjct: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIY--------LVFDFCEH-DLAGLLS 115 Query: 231 DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFH 410 + K + ++++ + GL+Y+H+ ILH D+K AN+L+ + V K+ADFG++R F Sbjct: 116 NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFS 175 Query: 411 EMQSRAIT--VNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILT 545 ++ N TL Y PE GE Y +D++ G I+ E+ T Sbjct: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224
>CDK9_HUMAN (P50750) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4) Length = 372 Score = 70.1 bits (170), Expect = 5e-12 Identities = 48/169 (28%), Positives = 83/169 (49%), Gaps = 4/169 (2%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R ++ L ++KH+NVV + C R G L F++ + L ++ Sbjct: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIY--------LVFDFCEH-DLAGLLS 115 Query: 231 DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFH 410 + K + ++++ + GL+Y+H+ ILH D+K AN+L+ + V K+ADFG++R F Sbjct: 116 NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFS 175 Query: 411 EMQSRAIT--VNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILT 545 ++ N TL Y PE GE Y +D++ G I+ E+ T Sbjct: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224
>CDK9_BOVIN (Q5EAB2) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 70.1 bits (170), Expect = 5e-12 Identities = 48/169 (28%), Positives = 83/169 (49%), Gaps = 4/169 (2%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R ++ L ++KH+NVV + C R G L F++ + L ++ Sbjct: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIY--------LVFDFCEH-DLAGLLS 115 Query: 231 DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFH 410 + K + ++++ + GL+Y+H+ ILH D+K AN+L+ + V K+ADFG++R F Sbjct: 116 NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFS 175 Query: 411 EMQSRAIT--VNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILT 545 ++ N TL Y PE GE Y +D++ G I+ E+ T Sbjct: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224
>CTK1_YEAST (Q03957) CTD kinase subunit alpha (EC 2.7.11.23) (CTD kinase 58 kDa| subunit) (CTDK-I alpha subunit) Length = 528 Score = 70.1 bits (170), Expect = 5e-12 Identities = 49/159 (30%), Positives = 80/159 (50%), Gaps = 3/159 (1%) Frame = +3 Query: 150 KFVMADVQQRL-LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILH 326 K +M + Q+ + + FEY N L + + ++ +C + K + G+ YLH ILH Sbjct: 246 KEIMVESQKTVYMIFEYADN-DLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILH 304 Query: 327 LDLKPANILLDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--Q 500 D+K +NIL+D KI DFG++R +M SRA N TL Y PE G Y + Sbjct: 305 RDVKGSNILIDNQGNLKITDFGLAR---KMNSRADYTNRVITLWYRPPELLLGTTNYGTE 361 Query: 501 LDIYSVGVIIIEILTGKKGYLAVDNVVESWSNKLEKSQS 617 +D++ G +++E+ + SN+LE+ +S Sbjct: 362 VDMWGCGCLLVELFN--------KTAIFQGSNELEQIES 392
>JAK1_BRARE (O12990) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1153 Score = 69.7 bits (169), Expect = 7e-12 Identities = 44/167 (26%), Positives = 78/167 (46%), Gaps = 2/167 (1%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R + L + H+N+V++ G C + G + L E+LP GSL +Y+ Sbjct: 921 REIHILRELYHENIVKYKGICNEEGGRSIK--------------LIMEFLPAGSLKEYLP 966 Query: 231 DTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFH 410 + + ICQG+ YL RN +H DL N+L++ KI DFG+++ Sbjct: 967 RNKAHINLKTLHNYSVQICQGMDYLGSRNYIHRDLAARNVLVENEGTVKIGDFGLTKSIK 1026 Query: 411 EMQS-RAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVIIIEILT 545 + + + ++ + + APE + + D++S GV + E+LT Sbjct: 1027 DNEGYYTVKDDLDSPVFWYAPECLIHCKFYRASDVWSFGVTMYELLT 1073 Score = 33.5 bits (75), Expect = 0.57 Identities = 40/178 (22%), Positives = 67/178 (37%), Gaps = 13/178 (7%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 F + + HK+ G C Q + ++ E++ G LD + Sbjct: 634 FFETASMMRQISHKHTALLYGVCVRHQ----------------ENIMVEEFVQYGPLDLF 677 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL-----LDGNLVP--KIA 383 + + + FQ+ K + L YL + ++H + NIL LDG P K++ Sbjct: 678 MRRQTTPLSTAWKFQVAKQLASALSYLEDKKMVHGYVCSKNILVARDGLDGEGGPFIKLS 737 Query: 384 DFGVSRCFHEMQSRAITVNIR----GTLGYLAPEFC--NGEITYQLDIYSVGVIIIEI 539 D G+ ITV R + ++APE +T D +S G + EI Sbjct: 738 DPGI----------PITVLSREECVDRIPWIAPECVKDTANLTIAADKWSFGTTLWEI 785
>DUN1_YEAST (P39009) DNA damage response protein kinase DUN1 (EC 2.7.11.1)| Length = 513 Score = 69.7 bits (169), Expect = 7e-12 Identities = 56/191 (29%), Positives = 88/191 (46%), Gaps = 21/191 (10%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSL- 215 K+F LM V+H N+V L + + Q+ L E + +G L Sbjct: 243 KQFREETNILMRVQHPNIVNLLDSFVEP-----------ISKSQIQKYLVLEKIDDGELF 291 Query: 216 DKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILL------------- 356 ++ + T + K + K + GL YLH++NI+H D+KP NILL Sbjct: 292 ERIVRKTCLRQDESKA--LFKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQL 349 Query: 357 ------DGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYS 515 + ++ KIADFG+++ EMQ T + GT Y+APE + T ++D++S Sbjct: 350 GPWDEDEIDIQVKIADFGLAKFTGEMQ---FTNTLCGTPSYVAPEVLTKKGYTSKVDLWS 406 Query: 516 VGVIIIEILTG 548 GVI+ L G Sbjct: 407 AGVILYVCLCG 417
>EPA4A_XENLA (Q91845) Ephrin type-A receptor 4-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK-1) (xSEK-1) Length = 986 Score = 69.7 bits (169), Expect = 7e-12 Identities = 43/137 (31%), Positives = 75/137 (54%), Gaps = 5/137 (3%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD 359 ++ EY+ NGSLD ++ + + I++GI G+ YL + +H DL NIL++ Sbjct: 695 MIITEYMENGSLDAFLRKNDGRFTVIQLVGILRGIGSGMKYLSDMSYVHRDLAARNILVN 754 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRG---TLGYLAPE-FCNGEITYQLDIYSVGVI 527 NLV K++DFG+SR + A T RG + + APE + T D++S G++ Sbjct: 755 SNLVCKVSDFGMSRVLEDDPEAAYTT--RGGKIPIRWTAPEAIAYRKFTSASDVWSYGIV 812 Query: 528 IIEILT-GKKGYLAVDN 575 + E+++ G++ Y + N Sbjct: 813 MWEVMSYGERPYWDMSN 829
>DAPK1_MOUSE (Q80YE7) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1442 Score = 69.7 bits (169), Expect = 7e-12 Identities = 58/191 (30%), Positives = 91/191 (47%), Gaps = 5/191 (2%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 ++ R V L ++H NV+ E Y K DV +L E + G L Sbjct: 59 EDIEREVSILKEIRHPNVITL----------HEVYENK---TDV---ILILELVAGGELF 102 Query: 219 KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVP----KIAD 386 ++ + + + + +K I G++YLH I H DLKP NI+L VP KI D Sbjct: 103 DFLAEKESLTE-EEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIID 161 Query: 387 FGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYL 563 FG++ H++ NI GT ++APE N E + + D++S+GVI +L+G +L Sbjct: 162 FGLA---HKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFL 218 Query: 564 AVDNVVESWSN 596 D E+ +N Sbjct: 219 G-DTKQETLAN 228
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 69.7 bits (169), Expect = 7e-12 Identities = 48/189 (25%), Positives = 88/189 (46%), Gaps = 5/189 (2%) Frame = +3 Query: 24 THMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLP 203 T ++F + H N++R G V+ + ++ EY+ Sbjct: 660 TEKQRRDFLGEASIMGQFDHPNIIRLEG----------------VVTKSKPVMIVTEYME 703 Query: 204 NGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIA 383 NGSLD ++ + + +++GI G+ YL +H DL NIL++ NLV K++ Sbjct: 704 NGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVS 763 Query: 384 DFGVSRCFHEMQSRAITVNIRG---TLGYLAPE-FCNGEITYQLDIYSVGVIIIEILT-G 548 DFG+SR + A T RG + + +PE + T D++S G+++ E+++ G Sbjct: 764 DFGLSRVLEDDPEAAYTT--RGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYG 821 Query: 549 KKGYLAVDN 575 ++ Y + N Sbjct: 822 ERPYWEMSN 830
>RIPK3_MOUSE (Q9QZL0) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) Length = 486 Score = 69.7 bits (169), Expect = 7e-12 Identities = 54/184 (29%), Positives = 91/184 (49%), Gaps = 9/184 (4%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K+ V+ ++ ++++NV+ LG D Q V + L ++ NGSL Sbjct: 56 KKISWEVKAMVNLRNENVLLLLGVTEDLQWDF-----------VSGQALVTRFMENGSLA 104 Query: 219 KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRN--ILHLDLKPANILLDGNLVPKIADFG 392 + + W ++++ + G+ YLH + +LH DLKP+NILLD L K+ADFG Sbjct: 105 GLLQPECPR-PWPLLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFG 163 Query: 393 VSRCFHEMQ----SRAITVNIRGTLGYLAPEF---CNGEITYQLDIYSVGVIIIEILTGK 551 +S Q S + + + GTL YL PE N + + D+YS G+++ +L G+ Sbjct: 164 LSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 Query: 552 KGYL 563 + L Sbjct: 224 EAEL 227
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 69.7 bits (169), Expect = 7e-12 Identities = 49/188 (26%), Positives = 90/188 (47%), Gaps = 5/188 (2%) Frame = +3 Query: 42 EFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDK 221 + + E L ++ H+N+++F G V+ + + EY GSL Sbjct: 49 KIEKEAEILSVLSHRNIIQFYG----------------VILEPPNYGIVTEYASLGSLYD 92 Query: 222 YI-TDTSRKVQWRKCFQIIKGICQGLHYLHQR---NILHLDLKPANILLDGNLVPKIADF 389 YI ++ S ++ + +G+HYLH ++H DLK N+++ + V KI DF Sbjct: 93 YINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDF 152 Query: 390 GVSRCFHEMQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILTGKKGYLA 566 G SR FH + +++ GT ++APE ++ D YS GV++ E+LT + + Sbjct: 153 GASR-FH---NHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKG 208 Query: 567 VDNVVESW 590 ++ + +W Sbjct: 209 LEGLQVAW 216
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 69.7 bits (169), Expect = 7e-12 Identities = 43/131 (32%), Positives = 74/131 (56%), Gaps = 3/131 (2%) Frame = +3 Query: 192 EYLPNGSLDKYI-TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNL 368 EY+ NGSL ++ T + K+ K + I +G+ ++ ++N +H DL+ ANIL+ L Sbjct: 316 EYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTL 375 Query: 369 VPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVIIIEILT 545 KIADFG++R + + A + + + APE N G T + D++S G+++ EI+T Sbjct: 376 SCKIADFGLARLIEDNEYTA-REGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVT 434 Query: 546 -GKKGYLAVDN 575 G+ Y + N Sbjct: 435 HGRIPYPGMTN 445
>SHK2_SCHPO (Q10056) Serine/threonine-protein kinase shk2 (EC 2.7.11.1)| Length = 589 Score = 69.3 bits (168), Expect = 9e-12 Identities = 44/130 (33%), Positives = 72/130 (55%), Gaps = 1/130 (0%) Frame = +3 Query: 192 EYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLV 371 EY+ GSL I + K+ + +I C+G+ +LH RNI+H D+K N+LLD + Sbjct: 390 EYMNAGSLTDIIEKS--KLTEAQIARICLETCKGIQHLHARNIIHRDIKSDNVLLDNSGN 447 Query: 372 PKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFC-NGEITYQLDIYSVGVIIIEILTG 548 KI DFG ++ +T + GT ++APE E ++DI+S+G++IIE++ Sbjct: 448 IKITDFGFCARLSNRTNKRVT--MVGTPYWMAPEVVKQNEYGTKVDIWSLGIMIIEMIEN 505 Query: 549 KKGYLAVDNV 578 + YL D + Sbjct: 506 EPPYLREDPI 515
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 69.3 bits (168), Expect = 9e-12 Identities = 43/131 (32%), Positives = 74/131 (56%), Gaps = 3/131 (2%) Frame = +3 Query: 192 EYLPNGSLDKYI-TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNL 368 E++ GSL ++ ++ K K I +G+ ++ QRN +H DL+ ANIL+ +L Sbjct: 310 EFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASL 369 Query: 369 VPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVIIIEILT 545 V KIADFG++R + + A + + + APE N G T + D++S G++++EI+T Sbjct: 370 VCKIADFGLARIIEDNEYTA-REGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT 428 Query: 546 -GKKGYLAVDN 575 G+ Y + N Sbjct: 429 YGRIPYPGMSN 439
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 69.3 bits (168), Expect = 9e-12 Identities = 43/131 (32%), Positives = 74/131 (56%), Gaps = 3/131 (2%) Frame = +3 Query: 192 EYLPNGSLDKYI-TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNL 368 E++ GSL ++ ++ K K I +G+ ++ QRN +H DL+ ANIL+ +L Sbjct: 331 EFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASL 390 Query: 369 VPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCN-GEITYQLDIYSVGVIIIEILT 545 V KIADFG++R + + A + + + APE N G T + D++S G++++EI+T Sbjct: 391 VCKIADFGLARIIEDNEYTA-REGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT 449 Query: 546 -GKKGYLAVDN 575 G+ Y + N Sbjct: 450 YGRIPYPGMSN 460
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 69.3 bits (168), Expect = 9e-12 Identities = 55/172 (31%), Positives = 85/172 (49%), Gaps = 5/172 (2%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYIT 230 R + L ++H N+V L V+ + L FE+L + L KY+ Sbjct: 50 REISLLKELQHPNIVCLLD----------------VLMQDSRLYLIFEFL-SMDLKKYL- 91 Query: 231 DTSRKVQWRKCFQI---IKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSR 401 D+ Q+ + + + I QG+ + H R +LH DLKP N+L+D V K+ADFG++R Sbjct: 92 DSIPSGQYLEAMLVKSYLYQILQGIIFCHARRVLHRDLKPQNLLIDSKGVIKLADFGLAR 151 Query: 402 CFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ--LDIYSVGVIIIEILTGK 551 F + R T + TL Y APE G + Y +D++S+G I EI + K Sbjct: 152 AF-GIPVRVYTHEV-VTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIASKK 201
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 69.3 bits (168), Expect = 9e-12 Identities = 53/180 (29%), Positives = 90/180 (50%), Gaps = 6/180 (3%) Frame = +3 Query: 57 VECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDT 236 + L + H+++V++LG + + + N + EY+P GS+ +T Sbjct: 448 IALLQELSHEHIVQYLG----SNLNSDHLN------------IFLEYVPGGSVAGLLTMY 491 Query: 237 SRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEM 416 + IK +GL YLH R I+H D+K ANIL+D KI+DFG+S+ E+ Sbjct: 492 G-SFEETLVKNFIKQTLKGLEYLHSRGIVHRDIKGANILVDNKGKIKISDFGISKKL-EL 549 Query: 417 QSRAITV-----NIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILTGKKGYLAVDNV 578 S + + +G+ ++APE + T + DI+S+G ++IE+LT K Y D + Sbjct: 550 NSTSTKTGGARPSFQGSSFWMAPEVVKQTMHTEKTDIWSLGCLVIEMLTSKHPYPNCDQM 609
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 69.3 bits (168), Expect = 9e-12 Identities = 41/124 (33%), Positives = 68/124 (54%), Gaps = 2/124 (1%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 + EY+ G L YI R + ++ ++ + I G+ Y H+ ++H DLKP N+LLD Sbjct: 91 MVMEYVSGGELFDYICKNGR-LDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDA 149 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIE 536 ++ KIADFG+S + + + G+ Y APE +G + ++DI+S GVI+ Sbjct: 150 HMNAKIADFGLSNMMSDGEFLRTSC---GSPNYAAPEVISGRLYAGPEVDIWSSGVILYA 206 Query: 537 ILTG 548 +L G Sbjct: 207 LLCG 210
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 69.3 bits (168), Expect = 9e-12 Identities = 41/124 (33%), Positives = 68/124 (54%), Gaps = 2/124 (1%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 + EY+ G L YI R + ++ ++ + I G+ Y H+ ++H DLKP N+LLD Sbjct: 91 MVMEYVSGGELFDYICKNGR-LDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDA 149 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIE 536 ++ KIADFG+S + + + G+ Y APE +G + ++DI+S GVI+ Sbjct: 150 HMNAKIADFGLSNMMSDGEFLRTSC---GSPNYAAPEVISGRLYAGPEVDIWSSGVILYA 206 Query: 537 ILTG 548 +L G Sbjct: 207 LLCG 210
>DAPK1_HUMAN (P53355) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1432 Score = 69.3 bits (168), Expect = 9e-12 Identities = 58/191 (30%), Positives = 91/191 (47%), Gaps = 5/191 (2%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 ++ R V L ++H NV+ E Y K DV +L E + G L Sbjct: 59 EDIEREVSILKEIQHPNVITL----------HEVYENK---TDV---ILILELVAGGELF 102 Query: 219 KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVP----KIAD 386 ++ + + + + +K I G++YLH I H DLKP NI+L VP KI D Sbjct: 103 DFLAEKESLTE-EEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIID 161 Query: 387 FGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYL 563 FG++ H++ NI GT ++APE N E + + D++S+GVI +L+G +L Sbjct: 162 FGLA---HKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFL 218 Query: 564 AVDNVVESWSN 596 D E+ +N Sbjct: 219 G-DTKQETLAN 228
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 69.3 bits (168), Expect = 9e-12 Identities = 41/124 (33%), Positives = 68/124 (54%), Gaps = 2/124 (1%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 + EY+ G L YI R + ++ ++ + I G+ Y H+ ++H DLKP N+LLD Sbjct: 93 MVMEYVSGGELFDYICKNGR-LDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDA 151 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIE 536 ++ KIADFG+S + + + G+ Y APE +G + ++DI+S GVI+ Sbjct: 152 HMNAKIADFGLSNMMSDGEFLRTSC---GSPNYAAPEVISGRLYAGPEVDIWSSGVILYA 208 Query: 537 ILTG 548 +L G Sbjct: 209 LLCG 212
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 69.3 bits (168), Expect = 9e-12 Identities = 41/124 (33%), Positives = 68/124 (54%), Gaps = 2/124 (1%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 + EY+ G L YI R + ++ ++ + I G+ Y H+ ++H DLKP N+LLD Sbjct: 93 MVMEYVSGGELFDYICKNGR-LDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDA 151 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIE 536 ++ KIADFG+S + + + G+ Y APE +G + ++DI+S GVI+ Sbjct: 152 HMNAKIADFGLSNMMSDGEFLRTSC---GSPNYAAPEVISGRLYAGPEVDIWSSGVILYA 208 Query: 537 ILTG 548 +L G Sbjct: 209 LLCG 212
>CIPK1_ORYSA (Q6X4A2) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1)| Length = 449 Score = 69.3 bits (168), Expect = 9e-12 Identities = 53/178 (29%), Positives = 81/178 (45%), Gaps = 4/178 (2%) Frame = +3 Query: 27 HMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPN 206 H ++ R + + +VKH NVVR + GS R + EY+ Sbjct: 59 HRLVEQIRREICTMKLVKHPNVVRLF----EVMGSKARI------------FIVLEYVTG 102 Query: 207 GSLDKYITDTSR--KVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKI 380 G L + I R + + RK FQ + + Y H R + H DLK N+LLD + K+ Sbjct: 103 GELFEIIATNGRLKEEEARKYFQ---QLINAVDYCHSRGVYHRDLKLENLLLDASGNLKV 159 Query: 381 ADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFC--NGEITYQLDIYSVGVIIIEILTG 548 +DFG+S ++++ + GT Y+APE G DI+S GVI+ +L G Sbjct: 160 SDFGLSALTEQVKADGLLHTTCGTPNYVAPEVIEDRGYDGAAADIWSCGVILYVLLAG 217
>CRK1_LEIME (Q06309) Cell division protein kinase 2 homolog CRK1 (EC 2.7.11.23)| Length = 301 Score = 68.9 bits (167), Expect = 1e-11 Identities = 51/169 (30%), Positives = 82/169 (48%), Gaps = 3/169 (1%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRL-LCFEYLPNGSLDKYI 227 R + L ++H+N+V+ L C + RL + FEYL + L KY+ Sbjct: 51 REISLLKELRHENIVKLLDVCHS-----------------EHRLTIVFEYL-DLDLKKYL 92 Query: 228 TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCF 407 + + ++ + +G+ + HQR++LH DLKP N+L+ K+ DFG+ R F Sbjct: 93 DRENGNLDAATIQHFMRDLLRGVAFCHQRSVLHRDLKPQNLLISREKELKLGDFGLGRSF 152 Query: 408 HEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTG 548 + R T N TL Y P+ G + Y +D++SVG I E+ TG Sbjct: 153 -AIPVRKFT-NEVVTLWYRPPDVLLGSMQYGPPVDVWSVGCIFSEMATG 199
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 68.9 bits (167), Expect = 1e-11 Identities = 55/178 (30%), Positives = 83/178 (46%), Gaps = 11/178 (6%) Frame = +3 Query: 51 RXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY-- 224 R + + +KH+N+VR V+ + L FE++ N L KY Sbjct: 52 REISLMKELKHENIVRLYD----------------VIHTENKLTLVFEFMDN-DLKKYMD 94 Query: 225 ---ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGV 395 + +T R ++ + QGL + H+ ILH DLKP N+L++ K+ DFG+ Sbjct: 95 SRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGL 154 Query: 396 SRCFHEMQSRAITVNIRG----TLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTGK 551 +R F I VN TL Y AP+ G TY +DI+S G I+ E++TGK Sbjct: 155 ARAF------GIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGK 206
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 68.9 bits (167), Expect = 1e-11 Identities = 42/137 (30%), Positives = 74/137 (54%), Gaps = 5/137 (3%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD 359 ++ EY+ NGSLD ++ + + +++GI G+ YL +H DL NIL++ Sbjct: 726 MIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILIN 785 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRG---TLGYLAPE-FCNGEITYQLDIYSVGVI 527 NLV K++DFG+SR + A T RG + + APE + T D++S G++ Sbjct: 786 SNLVCKVSDFGLSRVLEDDPEAAYTT--RGGKIPIRWTAPEAIAFRKFTSASDVWSYGIV 843 Query: 528 IIEILT-GKKGYLAVDN 575 + E+++ G++ Y + N Sbjct: 844 MWEVMSYGERPYWEMTN 860
>SN1L2_PONPY (Q5REX1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) Length = 925 Score = 68.9 bits (167), Expect = 1e-11 Identities = 53/176 (30%), Positives = 83/176 (47%), Gaps = 6/176 (3%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 ++ +R V+ + M+ H ++++ VM L EY NG + Sbjct: 62 EKIYREVQIMKMLDHPHIIKLYQ----------------VMETKSMLYLVTEYAKNGEIF 105 Query: 219 KYITDTSRKVQW---RKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADF 389 Y+ + R + RK +QI+ + Y H R I+H DLK N+LLD N+ KIADF Sbjct: 106 DYLANHGRLNESEARRKFWQILSAV----DYCHGRKIVHRDLKAENLLLDNNMNIKIADF 161 Query: 390 GVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY---QLDIYSVGVIIIEILTG 548 F +S + RG+ Y APE G+ Y QLDI+S+GV++ ++ G Sbjct: 162 SFGNFF---KSGELLATWRGSPPYAAPEVFEGQ-QYEGPQLDIWSMGVVLYVLVCG 213
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 68.9 bits (167), Expect = 1e-11 Identities = 39/134 (29%), Positives = 74/134 (55%), Gaps = 2/134 (1%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD 359 ++ E++ NG+LD ++ + ++ + +++GI G++YL N +H DL NIL++ Sbjct: 699 MIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVN 758 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIE 536 NL K++DFG++R + T + + + APE I T D++S G+++ E Sbjct: 759 QNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWE 818 Query: 537 ILT-GKKGYLAVDN 575 +L+ G K Y + N Sbjct: 819 VLSFGDKPYGEMSN 832
>YP150_YEAST (Q12152) Putative serine/threonine-protein kinase YPL150W (EC| 2.7.11.1) Length = 901 Score = 68.9 bits (167), Expect = 1e-11 Identities = 43/151 (28%), Positives = 74/151 (49%), Gaps = 2/151 (1%) Frame = +3 Query: 183 LCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDG 362 + EY P L ++ R++ +C ++ I ++Y H + +H DLK NILLD Sbjct: 109 MALEYCPGKELYDHLLSL-RRISLLECGELFAQISGAVYYAHSMHCVHRDLKLENILLDK 167 Query: 363 NLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEI--TYQLDIYSVGVIIIE 536 N K+ DFG +R E ++ + GT Y+APE +++DI+S+GVI+ Sbjct: 168 NGNAKLTDFGFTR---ECMTKTTLETVCGTTVYMAPELIERRTYDGFKIDIWSLGVILYT 224 Query: 537 ILTGKKGYLAVDNVVESWSNKLEKSQSDVQL 629 ++TG + D W E+ + D ++ Sbjct: 225 LITGYLPFDDDDEAKTKWKIVNEEPKYDAKV 255
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 68.9 bits (167), Expect = 1e-11 Identities = 51/169 (30%), Positives = 84/169 (49%), Gaps = 2/169 (1%) Frame = +3 Query: 45 FHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKY 224 + R +E L + H+++V++ G C D QG VQ L EY+P GSL Y Sbjct: 937 WQREIEILRTLYHEHIVKYKGCCED-QGEKS----------VQ---LVMEYVPLGSLRDY 982 Query: 225 ITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + V + + IC+G+ YLH ++ +H DL N+LLD + + KI DFG+++ Sbjct: 983 LP--RHCVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKA 1040 Query: 405 FHE-MQSRAITVNIRGTLGYLAPEFCNG-EITYQLDIYSVGVIIIEILT 545 E + + + + + APE + Y D++S GV + E+LT Sbjct: 1041 VPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLT 1089
>TLK1_CAEEL (P34314) Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1)| (Tousled-like kinase 1) Length = 965 Score = 68.9 bits (167), Expect = 1e-11 Identities = 54/178 (30%), Positives = 91/178 (51%), Gaps = 16/178 (8%) Frame = +3 Query: 75 VKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLC--FEYLPNGSLDKYITDTSRKV 248 ++ K++ + L +C R ++ + + C EY+P LD Y+ +R + Sbjct: 701 MREKDIHKSLDHC--------RIVKQYDLLTIDNHSFCTVLEYVPGNDLDFYLKQ-NRSI 751 Query: 249 QWRKCFQIIKGICQGLHYLHQRN--ILHLDLKPANILLD-GNL--VPKIADFGVSRCF-- 407 ++ II + L YL++++ I+H DLKPANILL+ GN KI DFG+S+ Sbjct: 752 SEKEARSIIMQVVSALVYLNEKSTPIIHYDLKPANILLESGNTSGAIKITDFGLSKIMEG 811 Query: 408 ----HEMQSRAITVNIRGTLGYLAPEFC---NGEITYQLDIYSVGVIIIEILTGKKGY 560 H++ +T GT YL PE +IT ++D++S+GVI + + GKK + Sbjct: 812 ESDDHDLGIE-LTSQFAGTYWYLPPETFIVPPPKITCKVDVWSIGVIFYQCIYGKKPF 868
>SKH1_SCHPO (Q9Y884) MAP kinase kinase skh1/pek1 (EC 2.7.12.2)| Length = 363 Score = 68.9 bits (167), Expect = 1e-11 Identities = 45/123 (36%), Positives = 65/123 (52%), Gaps = 4/123 (3%) Frame = +3 Query: 183 LCFEYLPNGSLD---KYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL 353 + EY GSLD K + + R +I G+ GL YLH R I+H D+KP+NIL Sbjct: 154 IAMEYCGAGSLDAIYKRVRSQGGRTGERPLGKIAFGVLSGLSYLHDRKIIHRDIKPSNIL 213 Query: 354 LDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVII 530 L K+ DFGVS E+ + ++ GT Y+APE G T DI+S+G+ + Sbjct: 214 LTSKGQVKLCDFGVS---GELVN-SLAGTFTGTSYYMAPERISGGSYTISSDIWSLGLTL 269 Query: 531 IEI 539 +E+ Sbjct: 270 MEV 272
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 68.9 bits (167), Expect = 1e-11 Identities = 38/109 (34%), Positives = 64/109 (58%), Gaps = 1/109 (0%) Frame = +3 Query: 282 ICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGY 461 IC+ L Y+H ++H DLKP+NI++D + ++ DFG+++ + + + GT Y Sbjct: 228 ICEALAYIHGHGLVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAAITEAGKLVGTYRY 287 Query: 462 LAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGYLAVDNVVESWSNKLE 605 +APE GE + + D+YS+GVI+ E+L+G+ + A E W LE Sbjct: 288 MAPEQILGEPLDGRADLYSLGVILYELLSGRPPFDA-KTPHELWRQVLE 335
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 68.9 bits (167), Expect = 1e-11 Identities = 49/196 (25%), Positives = 87/196 (44%), Gaps = 17/196 (8%) Frame = +3 Query: 39 KEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLD 218 K+F R E L ++H+++V+F G C D ++ FEY+ +G L+ Sbjct: 583 KDFQREAELLTNLQHEHIVKFYGVCGDGD----------------PLIMVFEYMKHGDLN 626 Query: 219 KYI---------------TDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL 353 K++ ++ + I I G+ YL ++ +H DL N Sbjct: 627 KFLRAHGPDAMILVDGQPXQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCX 686 Query: 354 LDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPE-FCNGEITYQLDIYSVGVII 530 + NL+ KI DFG+SR + + + + ++ PE + T + D++S GVI+ Sbjct: 687 VGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVIL 746 Query: 531 IEILT-GKKGYLAVDN 575 EI T GK+ + + N Sbjct: 747 WEIFTYGKQPWFQLSN 762
>SNF1_SCHPO (O74536) SNF1-like protein kinase ssp2 (EC 2.7.11.1)| Length = 576 Score = 68.6 bits (166), Expect = 2e-11 Identities = 47/128 (36%), Positives = 69/128 (53%), Gaps = 4/128 (3%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQ--WRKCFQIIKGICQGLHYLHQRNILHLDLKPANIL 353 ++ EY G L YI + R + R+ FQ I IC + Y H+ I+H DLKP N+L Sbjct: 108 VMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQI--IC-AIEYCHRHKIVHRDLKPENLL 163 Query: 354 LDGNLVPKIADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVI 527 LD NL KIADFG+S M G+ Y APE NG++ ++D++S G++ Sbjct: 164 LDDNLNVKIADFGLSNI---MTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWSCGIV 220 Query: 528 IIEILTGK 551 + +L G+ Sbjct: 221 LYVMLVGR 228
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 68.6 bits (166), Expect = 2e-11 Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 6/182 (3%) Frame = +3 Query: 21 NTHMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYL 200 N + +E + + L + H N+++ V D + L E+ Sbjct: 103 NIEKFHEEIYNEISLLKSLDHPNIIKLFD----------------VFEDKKYFYLVTEFY 146 Query: 201 PNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGN---LV 371 G L + I + K I+K I G+ YLH+ NI+H D+KP NILL+ L Sbjct: 147 EGGELFEQIINR-HKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLN 205 Query: 372 PKIADFGVSRCF---HEMQSRAITVNIRGTLGYLAPEFCNGEITYQLDIYSVGVIIIEIL 542 KI DFG+S F ++++ R GT Y+APE + + D++S GVI+ +L Sbjct: 206 IKIVDFGLSSFFSKDYKLRDRL------GTAYYIAPEVLKKKYNEKCDVWSCGVIMYILL 259 Query: 543 TG 548 G Sbjct: 260 CG 261
>MPK5_ARATH (Q39025) Mitogen-activated protein kinase homolog 5 (EC 2.7.11.24)| (MAP kinase 5) (AtMPK5) Length = 376 Score = 68.6 bits (166), Expect = 2e-11 Identities = 40/97 (41%), Positives = 55/97 (56%), Gaps = 2/97 (2%) Frame = +3 Query: 261 CFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSRAITVN 440 C + I +GL Y+H N+LH DLKP+N+LL+ N KI DFG++R E + V Sbjct: 146 CQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNSNCDLKITDFGLARTTSETEYMTEYVV 205 Query: 441 IRGTLGYLAPEFC--NGEITYQLDIYSVGVIIIEILT 545 R Y APE + E T +D++SVG I EI+T Sbjct: 206 TR---WYRAPELLLNSSEYTSAIDVWSVGCIFAEIMT 239
>CDKL2_RABIT (Q9TTK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 566 Score = 68.6 bits (166), Expect = 2e-11 Identities = 52/176 (29%), Positives = 84/176 (47%), Gaps = 2/176 (1%) Frame = +3 Query: 30 MYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNG 209 M +K R ++ L ++H+N+V L C +R+ F D L E PNG Sbjct: 43 MVKKIAMREIKLLKQLRHENLVNLLEVCK----KKKRWYLVFEFVD-HTILDDLELFPNG 97 Query: 210 SLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADF 389 D+ + + FQII GI + H NI+H D+KP NIL+ + V K+ DF Sbjct: 98 LDDQVVQ--------KYLFQIINGI----GFCHSHNIIHRDIKPENILVSQSGVVKLCDF 145 Query: 390 GVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTGK 551 G +R + + T Y APE G++ Y +D++++G ++ E+L G+ Sbjct: 146 GFARTL--AAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMLMGE 199
>CDKL2_MOUSE (Q9QUK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 568 Score = 68.6 bits (166), Expect = 2e-11 Identities = 51/179 (28%), Positives = 85/179 (47%), Gaps = 5/179 (2%) Frame = +3 Query: 30 MYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNG 209 M +K R ++ L ++H+N+V L C + + L FE++ + Sbjct: 43 MVKKIAMREIKLLKQLRHENLVNLLEVCKKKK----------------RWYLVFEFVDHT 86 Query: 210 SLDK---YITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKI 380 LD + +V + FQII GI + H NI+H D+KP NIL+ + V K+ Sbjct: 87 ILDDLKLFPNGLDYQVVQKYLFQIINGI----GFCHSHNIIHRDIKPENILVSQSGVVKL 142 Query: 381 ADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTGK 551 DFG +R + + T Y APE G++ Y +DI+++G ++IE+L G+ Sbjct: 143 CDFGFARTL--AAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQ 199
>EPA4B_XENLA (Q91694) Ephrin type-A receptor 4-B precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor PAG) (Pagliaccio) Length = 985 Score = 68.6 bits (166), Expect = 2e-11 Identities = 42/137 (30%), Positives = 75/137 (54%), Gaps = 5/137 (3%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD 359 ++ EY+ NGSLD ++ + + +++GI G+ YL + +H DL NIL++ Sbjct: 695 MIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVN 754 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRG---TLGYLAPE-FCNGEITYQLDIYSVGVI 527 NLV K++DFG+SR + A T RG + + APE + T D++S G++ Sbjct: 755 SNLVCKVSDFGMSRVLEDDPEAAYTT--RGGKIPIRWTAPEAIAYRKFTSASDVWSYGIV 812 Query: 528 IIEILT-GKKGYLAVDN 575 + E+++ G++ Y + N Sbjct: 813 MWEVMSYGERPYWDMSN 829
>AVR2A_SHEEP (Q28560) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 68.6 bits (166), Expect = 2e-11 Identities = 51/171 (29%), Positives = 85/171 (49%), Gaps = 16/171 (9%) Frame = +3 Query: 75 VKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDTSRKVQW 254 +KH+N+++F+G A+ +G+ DV L+ + GSL ++ + V W Sbjct: 241 MKHENILQFIG--AEKRGTS---------VDVDLWLIT-AFHEKGSLSDFLK--ANVVSW 286 Query: 255 RKCFQIIKGICQGLHYLHQR----------NILHLDLKPANILLDGNLVPKIADFGVSRC 404 + I + + +GL YLH+ I H D+K N+LL NL IADFG++ Sbjct: 287 NELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALK 346 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ------LDIYSVGVIIIEI 539 F +S T GT Y+APE G I +Q +D+Y++G+++ E+ Sbjct: 347 FEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 397
>AVR2A_MOUSE (P27038) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 68.6 bits (166), Expect = 2e-11 Identities = 51/171 (29%), Positives = 85/171 (49%), Gaps = 16/171 (9%) Frame = +3 Query: 75 VKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDTSRKVQW 254 +KH+N+++F+G A+ +G+ DV L+ + GSL ++ + V W Sbjct: 241 MKHENILQFIG--AEKRGTS---------VDVDLWLIT-AFHEKGSLSDFLK--ANVVSW 286 Query: 255 RKCFQIIKGICQGLHYLHQR----------NILHLDLKPANILLDGNLVPKIADFGVSRC 404 + I + + +GL YLH+ I H D+K N+LL NL IADFG++ Sbjct: 287 NELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALK 346 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ------LDIYSVGVIIIEI 539 F +S T GT Y+APE G I +Q +D+Y++G+++ E+ Sbjct: 347 FEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 397
>AVR2A_HUMAN (P27037) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) (ACTRIIA) Length = 513 Score = 68.6 bits (166), Expect = 2e-11 Identities = 51/171 (29%), Positives = 85/171 (49%), Gaps = 16/171 (9%) Frame = +3 Query: 75 VKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDTSRKVQW 254 +KH+N+++F+G A+ +G+ DV L+ + GSL ++ + V W Sbjct: 241 MKHENILQFIG--AEKRGTS---------VDVDLWLIT-AFHEKGSLSDFLK--ANVVSW 286 Query: 255 RKCFQIIKGICQGLHYLHQR----------NILHLDLKPANILLDGNLVPKIADFGVSRC 404 + I + + +GL YLH+ I H D+K N+LL NL IADFG++ Sbjct: 287 NELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALK 346 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ------LDIYSVGVIIIEI 539 F +S T GT Y+APE G I +Q +D+Y++G+++ E+ Sbjct: 347 FEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 397
>AVR2A_BOVIN (Q28043) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 68.6 bits (166), Expect = 2e-11 Identities = 51/171 (29%), Positives = 85/171 (49%), Gaps = 16/171 (9%) Frame = +3 Query: 75 VKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNGSLDKYITDTSRKVQW 254 +KH+N+++F+G A+ +G+ DV L+ + GSL ++ + V W Sbjct: 241 MKHENILQFIG--AEKRGTS---------VDVDLWLIT-AFHEKGSLSDFLK--ANVVSW 286 Query: 255 RKCFQIIKGICQGLHYLHQR----------NILHLDLKPANILLDGNLVPKIADFGVSRC 404 + I + + +GL YLH+ I H D+K N+LL NL IADFG++ Sbjct: 287 NELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALK 346 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ------LDIYSVGVIIIEI 539 F +S T GT Y+APE G I +Q +D+Y++G+++ E+ Sbjct: 347 FEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 397
>CDKL2_RAT (Q5XIT0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 507 Score = 68.6 bits (166), Expect = 2e-11 Identities = 51/179 (28%), Positives = 85/179 (47%), Gaps = 5/179 (2%) Frame = +3 Query: 30 MYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNG 209 M +K R ++ L ++H+N+V L C + + L FE++ + Sbjct: 43 MVKKIAMREIKLLKQLRHENLVNLLEVCKKKK----------------RWYLVFEFVDHT 86 Query: 210 SLDK---YITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKI 380 LD + +V + FQII GI + H NI+H D+KP NIL+ + V K+ Sbjct: 87 ILDDLKLFPNGLDYQVVQKYLFQIINGI----GFCHSHNIIHRDIKPENILVSQSGVVKL 142 Query: 381 ADFGVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITY--QLDIYSVGVIIIEILTGK 551 DFG +R + + T Y APE G++ Y +DI+++G ++IE+L G+ Sbjct: 143 CDFGFARTL--AAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQ 199
>FGFR3_HUMAN (P22607) Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1)| (FGFR-3) (CD333 antigen) Length = 806 Score = 68.6 bits (166), Expect = 2e-11 Identities = 54/168 (32%), Positives = 87/168 (51%), Gaps = 9/168 (5%) Frame = +3 Query: 69 MMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYL----PNGSLDKYITDT 236 M+ KHKN++ LG C TQG +V+ + + E+L P G LD Y DT Sbjct: 531 MIGKHKNIINLLGAC--TQGGP-----LYVLVEYAAKGNLREFLRARRPPG-LD-YSFDT 581 Query: 237 SRKVQWRKCFQIIKG----ICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRC 404 + + + F+ + + +G+ YL + +H DL N+L+ + V KIADFG++R Sbjct: 582 CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD 641 Query: 405 FHEMQSRAITVNIRGTLGYLAPEFCNGEI-TYQLDIYSVGVIIIEILT 545 H + T N R + ++APE + T+Q D++S GV++ EI T Sbjct: 642 VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT 689
>MOS_PIG (P50118) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 345 Score = 68.6 bits (166), Expect = 2e-11 Identities = 48/166 (28%), Positives = 80/166 (48%), Gaps = 4/166 (2%) Frame = +3 Query: 75 VKHKNVVRFLGYCADTQGSMERYNGKFVM---ADVQQRLLCFEYLPNGSLDKYITDTSRK 245 ++H N+VR + T + + G +M +V + + D + Sbjct: 115 LRHANIVRVVAASTRTPAAFDSL-GSIIMEFGGNVTLHQVIYGATGCPEEDGPPCSAGEQ 173 Query: 246 VQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADFGVSRCFHEMQSR 425 + KC + + GL +LH + I+HLDLKPANIL+ V KI+DFG S +++ R Sbjct: 174 LNLEKCLKYSLDVVSGLLFLHSQGIVHLDLKPANILISEQDVCKISDFGCSERLEDLRFR 233 Query: 426 AITVNIRGTLGYLAPEFCNGE-ITYQLDIYSVGVIIIEILTGKKGY 560 ++ GT + APE GE +T + DIYS + + ++ T + Y Sbjct: 234 P-RHHLGGTYTHRAPELLKGEPVTPKADIYSFAITLWQMTTRQVPY 278
>MK14_XENLA (P47812) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated Mitogen-activated protein kinase 2) (MAP kinase 2) (MPK2) Length = 361 Score = 68.6 bits (166), Expect = 2e-11 Identities = 53/185 (28%), Positives = 92/185 (49%), Gaps = 2/185 (1%) Frame = +3 Query: 30 MYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLPNG 209 ++ K +R + L +KH+NV+ L + + S E +N +++ + L Sbjct: 64 IHAKRTYRELRLLKHMKHENVIGLLDVFSPAK-SFEEFNDVYLVTHLMGADL-------N 115 Query: 210 SLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIADF 389 ++ K T VQ+ +I I +GL Y+H I+H DLKP+N+ ++ + KI DF Sbjct: 116 NIVKCQKLTDDHVQF-----LIYQILRGLKYIHSAGIIHRDLKPSNLAVNEDCELKILDF 170 Query: 390 GVSRCFHEMQSRAITVNIRGTLGYLAPEFCNGEITYQ--LDIYSVGVIIIEILTGKKGYL 563 G++R E + + T Y APE + Y +DI+SVG I+ E+LTG+ + Sbjct: 171 GLARHTDEEMTGYV-----ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFP 225 Query: 564 AVDNV 578 D++ Sbjct: 226 GTDHI 230
>EPHA4_MOUSE (Q03137) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (MPK-3) Length = 986 Score = 68.6 bits (166), Expect = 2e-11 Identities = 42/137 (30%), Positives = 75/137 (54%), Gaps = 5/137 (3%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD 359 ++ EY+ NGSLD ++ + + +++GI G+ YL + +H DL NIL++ Sbjct: 696 MIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVN 755 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRG---TLGYLAPE-FCNGEITYQLDIYSVGVI 527 NLV K++DFG+SR + A T RG + + APE + T D++S G++ Sbjct: 756 SNLVCKVSDFGMSRVLEDDPEAAYTT--RGGKIPIRWTAPEAIAYRKFTSASDVWSYGIV 813 Query: 528 IIEILT-GKKGYLAVDN 575 + E+++ G++ Y + N Sbjct: 814 MWEVMSYGERPYWDMSN 830
>EPHA4_HUMAN (P54764) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8) Length = 986 Score = 68.6 bits (166), Expect = 2e-11 Identities = 42/137 (30%), Positives = 75/137 (54%), Gaps = 5/137 (3%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD 359 ++ EY+ NGSLD ++ + + +++GI G+ YL + +H DL NIL++ Sbjct: 696 MIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVN 755 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRG---TLGYLAPE-FCNGEITYQLDIYSVGVI 527 NLV K++DFG+SR + A T RG + + APE + T D++S G++ Sbjct: 756 SNLVCKVSDFGMSRVLEDDPEAAYTT--RGGKIPIRWTAPEAIAYRKFTSASDVWSYGIV 813 Query: 528 IIEILT-GKKGYLAVDN 575 + E+++ G++ Y + N Sbjct: 814 MWEVMSYGERPYWDMSN 830
>EPHA4_CHICK (Q07496) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK8) Length = 986 Score = 68.6 bits (166), Expect = 2e-11 Identities = 42/137 (30%), Positives = 75/137 (54%), Gaps = 5/137 (3%) Frame = +3 Query: 180 LLCFEYLPNGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLD 359 ++ EY+ NGSLD ++ + + +++GI G+ YL + +H DL NIL++ Sbjct: 696 MIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVN 755 Query: 360 GNLVPKIADFGVSRCFHEMQSRAITVNIRG---TLGYLAPE-FCNGEITYQLDIYSVGVI 527 NLV K++DFG+SR + A T RG + + APE + T D++S G++ Sbjct: 756 SNLVCKVSDFGMSRVLEDDPEAAYTT--RGGKIPIRWTAPEAIAYRKFTSASDVWSYGIV 813 Query: 528 IIEILT-GKKGYLAVDN 575 + E+++ G++ Y + N Sbjct: 814 MWEVMSYGERPYWDMSN 830
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 68.6 bits (166), Expect = 2e-11 Identities = 48/189 (25%), Positives = 88/189 (46%), Gaps = 5/189 (2%) Frame = +3 Query: 24 THMYEKEFHRXVECLMMVKHKNVVRFLGYCADTQGSMERYNGKFVMADVQQRLLCFEYLP 203 T ++F + H N++R G V+ + ++ EY+ Sbjct: 661 TEKQRRDFLGEASIMGQFDHPNIIRLEG----------------VVTKSKPVMIVTEYME 704 Query: 204 NGSLDKYITDTSRKVQWRKCFQIIKGICQGLHYLHQRNILHLDLKPANILLDGNLVPKIA 383 NGSLD ++ + + +++GI G+ YL +H DL NIL++ NLV K++ Sbjct: 705 NGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVS 764 Query: 384 DFGVSRCFHEMQSRAITVNIRG---TLGYLAPE-FCNGEITYQLDIYSVGVIIIEILT-G 548 DFG+SR + A T RG + + +PE + T D++S G+++ E+++ G Sbjct: 765 DFGLSRVLEDDPEAAYTT--RGGKIPVRWTSPEATAYRKFTSASDVWSYGIVLWEVMSYG 822 Query: 549 KKGYLAVDN 575 ++ Y + N Sbjct: 823 ERPYWEMSN 831 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 97,478,925 Number of Sequences: 219361 Number of extensions: 2163356 Number of successful extensions: 8408 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 7045 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7377 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6200242422 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
