ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | basdk20 |
|---|---|
| Clone Library Name | barley_pub |
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 145 bits (366), Expect = 1e-34 Identities = 73/168 (43%), Positives = 108/168 (64%) Frame = +3 Query: 117 ELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQL 296 +L+ +L + T+ F + +LIG G +G VY AIL G +A+KKL + D EF+ ++ Sbjct: 870 KLTFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKL-IHVSGQGDREFMAEM 928 Query: 297 SIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQR 476 + ++KH N V +LGYC G++RL+ YEF GSL D+LH K + G L+W R Sbjct: 929 ETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPK-----KAGVKLNWSTR 983 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 KIAI +A+GLA+LH P I+HRD++SSNVLL E+ A+V+DF ++ Sbjct: 984 RKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMA 1031
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 142 bits (359), Expect = 6e-34 Identities = 73/168 (43%), Positives = 106/168 (63%) Frame = +3 Query: 117 ELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQL 296 +L+ +L E T+ F + +L+G G +G VY A L G +A+KKL + D EF ++ Sbjct: 875 KLTFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKL-IHVSGQGDREFTAEM 933 Query: 297 SIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQR 476 + ++KH N V +LGYC G +RL+ YE+ GSL D+LH RK + G L+W R Sbjct: 934 ETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKI-----GIKLNWPAR 988 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 KIAI AA+GLA+LH P I+HRD++SSNVLL E+ A+V+DF ++ Sbjct: 989 RKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMA 1036
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 142 bits (358), Expect = 8e-34 Identities = 71/168 (42%), Positives = 105/168 (62%) Frame = +3 Query: 117 ELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQL 296 +L+ L E T+ F ++ ++G G +G VY A L G +A+KKL + D EF+ ++ Sbjct: 846 KLTFAHLLEATNGFSAETMVGSGGFGEVYKAQLRDGSVVAIKKL-IRITGQGDREFMAEM 904 Query: 297 SIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQR 476 + ++KH N V +LGYC G +RL+ YE+ GSL +LH + G G L+W R Sbjct: 905 ETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKG---GIYLNWAAR 961 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 KIAI AA+GLA+LH P I+HRD++SSNVLL ED+ A+V+DF ++ Sbjct: 962 KKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMA 1009
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 142 bits (358), Expect = 8e-34 Identities = 73/168 (43%), Positives = 106/168 (63%) Frame = +3 Query: 117 ELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQL 296 +L+ +L E T+ F + +L+G G +G VY A L G +A+KKL + D EF ++ Sbjct: 875 KLTFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKL-IHVSGQGDREFTAEM 933 Query: 297 SIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQR 476 + ++KH N V +LGYC G +RL+ YE+ GSL D+LH RK + G L+W R Sbjct: 934 ETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRK-----KTGIKLNWPAR 988 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 KIAI AA+GLA+LH P I+HRD++SSNVLL E+ A+V+DF ++ Sbjct: 989 RKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMA 1036
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 140 bits (353), Expect = 3e-33 Identities = 76/168 (45%), Positives = 108/168 (64%), Gaps = 1/168 (0%) Frame = +3 Query: 132 ELKEKTDNFGSKALIGEGSYGRVYYAILDS-GKHLAVKKLDTSADPEPDNEFLTQLSIVS 308 EL T NF +GEG +GRVY LDS G+ +AVK+LD + + + EFL ++ ++S Sbjct: 78 ELAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNG-LQGNREFLVEVLMLS 136 Query: 309 RLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIA 488 L H N V ++GYC +G+QRL+ YEF +GSL D LH +P + ALDW R+KIA Sbjct: 137 LLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLH---DLPPDK--EALDWNMRMKIA 191 Query: 489 IDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSP 632 AAKGL +LH+K P +++RD +SSN+LL E + K++DF L+ P Sbjct: 192 AGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLGP 239
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 140 bits (353), Expect = 3e-33 Identities = 76/200 (38%), Positives = 119/200 (59%), Gaps = 7/200 (3%) Frame = +3 Query: 54 EGNGFDTKSDPTKAPPPIE------IPELSLDELKEKTDNFGSKALIGEGSYGRVYYAIL 215 + + + D K P +E E S +EL++ T F + +G+GS+ V+ IL Sbjct: 465 KSTAYSFRKDNMKIQPDMEDLKIRRAQEFSYEELEQATGGFSEDSQVGKGSFSCVFKGIL 524 Query: 216 DSGKHLAVKKLDTSADPEPDN-EFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFAT 392 G +AVK+ ++D + + EF +L ++SRL H + + +LGYC +G++RL+ YEF Sbjct: 525 RDGTVVAVKRAIKASDVKKSSKEFHNELDLLSRLNHAHLLNLLGYCEDGSERLLVYEFMA 584 Query: 393 MGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNV 572 GSL+ LHG+ P + L+W +RV IA+ AA+G+ YLH P ++HRDI+SSN+ Sbjct: 585 HGSLYQHLHGKD--PNLKK--RLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNI 640 Query: 573 LLFEDYRAKVADFNLSNQSP 632 L+ ED+ A+VADF LS P Sbjct: 641 LIDEDHNARVADFGLSILGP 660
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 139 bits (349), Expect = 9e-33 Identities = 71/168 (42%), Positives = 105/168 (62%) Frame = +3 Query: 117 ELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQL 296 +L+ L E T+ F + ++IG G +G VY A L G +A+KKL + D EF+ ++ Sbjct: 845 KLTFAHLLEATNGFSADSMIGSGGFGDVYKAKLADGSVVAIKKL-IQVTGQGDREFMAEM 903 Query: 297 SIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQR 476 + ++KH N V +LGYC G +RL+ YE+ GSL +LH + + G LDW R Sbjct: 904 ETIGKIKHRNLVPLLGYCKIGEERLLVYEYMKYGSLETVLHEKT----KKGGIFLDWSAR 959 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 KIAI AA+GLA+LH P I+HRD++SSNVLL +D+ A+V+DF ++ Sbjct: 960 KKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDQDFVARVSDFGMA 1007
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 138 bits (347), Expect = 2e-32 Identities = 69/171 (40%), Positives = 105/171 (61%) Frame = +3 Query: 108 EIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFL 287 ++ +L +L E T+ F + ++IG G +G V+ A L G +A+KKL + D EF+ Sbjct: 822 QLRKLKFSQLIEATNGFSAASMIGHGGFGEVFKATLKDGSSVAIKKL-IRLSCQGDREFM 880 Query: 288 TQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDW 467 ++ + ++KH N V +LGYC G +RL+ YEF GSL ++LHG + + L W Sbjct: 881 AEMETLGKIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVLHGPRT---GEKRRILGW 937 Query: 468 MQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 +R KIA AAKGL +LH P I+HRD++SSNVLL +D A+V+DF ++ Sbjct: 938 EERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGMA 988
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 137 bits (345), Expect = 3e-32 Identities = 79/218 (36%), Positives = 122/218 (55%), Gaps = 13/218 (5%) Frame = +3 Query: 6 TRREHEHEFPSAQXEKEGNGFDTKS------DPTKAPPPIEIP-------ELSLDELKEK 146 T+R + + P E GF ++ ++ P I I ++ L ++ E Sbjct: 854 TKRVKQRDDPERMEESRLKGFVDQNLYFLSGSRSREPLSINIAMFEQPLLKVRLGDIVEA 913 Query: 147 TDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHEN 326 TD+F K +IG+G +G VY A L K +AVKKL + A + + EF+ ++ + ++KH N Sbjct: 914 TDHFSKKNIIGDGGFGTVYKACLPGEKTVAVKKL-SEAKTQGNREFMAEMETLGKVKHPN 972 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKG 506 V +LGYC ++L+ YE+ GSL L + G+ LDW +R+KIA+ AA+G Sbjct: 973 LVSLLGYCSFSEEKLLVYEYMVNGSLDHWLRNQTGML-----EVLDWSKRLKIAVGAARG 1027 Query: 507 LAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 LA+LH P I+HRDI++SN+LL D+ KVADF L+ Sbjct: 1028 LAFLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLA 1065
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 134 bits (338), Expect = 2e-31 Identities = 72/176 (40%), Positives = 110/176 (62%) Frame = +3 Query: 105 IEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEF 284 + + +L+ +++ T+ + K LIGEG +G VY LD G+ +AVK + +S + EF Sbjct: 581 VSVKPFTLEYIEQATEQY--KTLIGEGGFGSVYRGTLDDGQEVAVK-VRSSTSTQGTREF 637 Query: 285 LTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALD 464 +L+++S ++HEN V +LGYC E +Q+++ Y F + GSL D L+G A LD Sbjct: 638 DNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGE-----ASKRKILD 692 Query: 465 WMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSP 632 W R+ IA+ AA+GLAYLH S++HRD++SSN+LL + AKVADF S +P Sbjct: 693 WPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKYAP 748
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 133 bits (335), Expect = 4e-31 Identities = 71/168 (42%), Positives = 103/168 (61%) Frame = +3 Query: 117 ELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQL 296 ELSLD++ + T +F +IG G +G VY A L G +A+K+L + D EF ++ Sbjct: 730 ELSLDDILKSTSSFNQANIIGCGGFGLVYKATLPDGTKVAIKRLSGDTG-QMDREFQAEV 788 Query: 297 SIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQR 476 +SR +H N V +LGYC N +L+ Y + GSL LH + P P+LDW R Sbjct: 789 ETLSRAQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLHEKVDGP-----PSLDWKTR 843 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 ++IA AA+GLAYLH+ +P I+HRDI+SSN+LL + + A +ADF L+ Sbjct: 844 LRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLSDTFVAHLADFGLA 891
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 132 bits (332), Expect = 9e-31 Identities = 68/171 (39%), Positives = 108/171 (63%), Gaps = 1/171 (0%) Frame = +3 Query: 123 SLDELKEKTDNFGSKALIGEGSYGRVYYAILDS-GKHLAVKKLDTSADPEPDNEFLTQLS 299 + EL E T NF S +GEG +G+V+ ++ + +A+K+LD + + EF+ ++ Sbjct: 92 TFQELAEATGNFRSDCFLGEGGFGKVFKGTIEKLDQVVAIKQLDRNG-VQGIREFVVEVL 150 Query: 300 IVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRV 479 +S H N V+++G+C EG+QRL+ YE+ GSL D LH G +P LDW R+ Sbjct: 151 TLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHVLPS--GKKP---LDWNTRM 205 Query: 480 KIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSP 632 KIA AA+GL YLH+++ P +++RD++ SN+LL EDY+ K++DF L+ P Sbjct: 206 KIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKVGP 256
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 129 bits (323), Expect = 1e-29 Identities = 70/176 (39%), Positives = 107/176 (60%) Frame = +3 Query: 105 IEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEF 284 + + +L+ ++ T+ + K LIGEG +G VY LD G+ +AVK + ++ + EF Sbjct: 580 VSVKPFTLEYIELATEKY--KTLIGEGGFGSVYRGTLDDGQEVAVK-VRSATSTQGTREF 636 Query: 285 LTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALD 464 +L+++S ++HEN V +LGYC E +Q+++ Y F + GSL D L+G LD Sbjct: 637 DNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEPA-----KRKILD 691 Query: 465 WMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSP 632 W R+ IA+ AA+GLAYLH S++HRD++SSN+LL AKVADF S +P Sbjct: 692 WPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKVADFGFSKYAP 747
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 129 bits (323), Expect = 1e-29 Identities = 66/182 (36%), Positives = 109/182 (59%), Gaps = 3/182 (1%) Frame = +3 Query: 84 PTKAPPPIEIPEL---SLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDT 254 P + P + + +L SL EL+ +DNF +K ++G G +G+VY L G +AVK+L Sbjct: 262 PAEEDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTLVAVKRLKE 321 Query: 255 SADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGV 434 + +F T++ ++S H N + + G+C+ +RL+ Y + GS+ L R Sbjct: 322 ERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRER--- 378 Query: 435 PGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFN 614 P +Q P LDW +R +IA+ +A+GLAYLH+ P I+HRD++++N+LL E++ A V DF Sbjct: 379 PESQ--PPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFG 436 Query: 615 LS 620 L+ Sbjct: 437 LA 438
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 128 bits (321), Expect = 2e-29 Identities = 73/169 (43%), Positives = 101/169 (59%), Gaps = 1/169 (0%) Frame = +3 Query: 117 ELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQL 296 ELS D+L + T++F +IG G +G VY A L GK +A+KKL + + EF ++ Sbjct: 721 ELSYDDLLDSTNSFDQANIIGCGGFGMVYKATLPDGKKVAIKKLSGDCG-QIEREFEAEV 779 Query: 297 SIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPAL-DWMQ 473 +SR +H N V + G+C N RL+ Y + GSL LH R GPAL W Sbjct: 780 ETLSRAQHPNLVLLRGFCFYKNDRLLIYSYMENGSLDYWLHERND------GPALLKWKT 833 Query: 474 RVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 R++IA AAKGL YLHE P I+HRDI+SSN+LL E++ + +ADF L+ Sbjct: 834 RLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLADFGLA 882
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 124 bits (312), Expect = 2e-28 Identities = 63/173 (36%), Positives = 106/173 (61%), Gaps = 1/173 (0%) Frame = +3 Query: 120 LSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPD-NEFLTQL 296 +S+ L+ T+NF S ++G G +G VY L G +AVK+++ EF +++ Sbjct: 576 ISIQVLRSVTNNFSSDNILGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKGFAEFKSEI 635 Query: 297 SIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQR 476 +++++++H + V +LGYC++GN++L+ YE+ G+L L G +P L W QR Sbjct: 636 AVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLF-EWSEEGLKP---LLWKQR 691 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 + +A+D A+G+ YLH S +HRD++ SN+LL +D RAKVADF L +P+ Sbjct: 692 LTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAPE 744
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 121 bits (304), Expect = 2e-27 Identities = 70/170 (41%), Positives = 100/170 (58%), Gaps = 10/170 (5%) Frame = +3 Query: 141 EKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPD---------NEFLTQ 293 E D K +IG GS G+VY L G+ +AVKKL+ S D + F + Sbjct: 678 EIADCLDEKNVIGFGSSGKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAE 737 Query: 294 LSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHG-RKGVPGAQPGPALDWM 470 + + ++H++ V + C G+ +L+ YE+ GSL D+LHG RKG G L W Sbjct: 738 VETLGTIRHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKG------GVVLGWP 791 Query: 471 QRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 +R++IA+DAA+GL+YLH P IVHRD++SSN+LL DY AKVADF ++ Sbjct: 792 ERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIA 841
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 120 bits (302), Expect = 3e-27 Identities = 70/184 (38%), Positives = 110/184 (59%), Gaps = 10/184 (5%) Frame = +3 Query: 111 IPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILD----------SGKHLAVKKLDTSA 260 + SL ELK T NF +++GEG +G V+ +D +G +AVK+L+ Sbjct: 53 LKNFSLSELKSATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRLNQEG 112 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPG 440 + E+L +++ + +L H N V+++GYC+E RL+ YEF T GSL + L R+G Sbjct: 113 F-QGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLF-RRGT-F 169 Query: 441 AQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 QP L W RV++A+ AA+GLA+LH QP +++RD ++SN+LL +Y AK++DF L+ Sbjct: 170 YQP---LSWNTRVRMALGAARGLAFLH-NAQPQVIYRDFKASNILLDSNYNAKLSDFGLA 225 Query: 621 NQSP 632 P Sbjct: 226 RDGP 229
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 115 bits (287), Expect = 1e-25 Identities = 66/177 (37%), Positives = 103/177 (58%), Gaps = 10/177 (5%) Frame = +3 Query: 132 ELKEKTDNFGSKALIGEGSYGRVYYAILD----------SGKHLAVKKLDTSADPEPDNE 281 ELK T NF +++GEG +G V+ +D +G +AVKKL+ + E Sbjct: 61 ELKAATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPGTGVVIAVKKLNQDGW-QGHQE 119 Query: 282 FLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPAL 461 +L +++ + + H N V+++GYC+E RL+ YEF GSL + L R QP L Sbjct: 120 WLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGSY--FQP---L 174 Query: 462 DWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSP 632 W R+K+A+ AAKGLA+LH + S+++RD ++SN+LL +Y AK++DF L+ P Sbjct: 175 SWTLRLKVALGAAKGLAFLH-NAETSVIYRDFKTSNILLDSEYNAKLSDFGLAKDGP 230
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 114 bits (285), Expect = 2e-25 Identities = 58/172 (33%), Positives = 106/172 (61%) Frame = +3 Query: 105 IEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEF 284 +E+P + ++ + + T+NF S +G+G +G VY L GK +AVK+L ++ D EF Sbjct: 511 LELPLIEMETVVKATENFSSCNKLGQGGFGIVYKGRLLDGKEIAVKRLSKTSVQGTD-EF 569 Query: 285 LTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALD 464 + ++++++RL+H N V++LG C+EG+++++ YE+ SL L G+ L+ Sbjct: 570 MNEVTLIARLQHINLVQVLGCCIEGDEKMLIYEYLENLSLDSYLFGKTR------RSKLN 623 Query: 465 WMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 W +R I A+GL YLH+ + I+HRD++ SN+LL ++ K++DF ++ Sbjct: 624 WNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFGMA 675
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 114 bits (284), Expect = 3e-25 Identities = 61/163 (37%), Positives = 101/163 (61%) Frame = +3 Query: 132 ELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSR 311 E+ T+NF + +IG+G +G+VY+ +++ G+ +AVK L + + EF ++ ++ R Sbjct: 568 EVVNITNNF--ERVIGKGGFGKVYHGVIN-GEQVAVKVLSEES-AQGYKEFRAEVDLLMR 623 Query: 312 LKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAI 491 + H N ++GYC E N ++ YE+ +L D L G++ L W +R+KI++ Sbjct: 624 VHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYLAGKRSF-------ILSWEERLKISL 676 Query: 492 DAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 DAA+GL YLH +P IVHRD++ +N+LL E +AK+ADF LS Sbjct: 677 DAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLS 719
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 114 bits (284), Expect = 3e-25 Identities = 80/231 (34%), Positives = 125/231 (54%), Gaps = 32/231 (13%) Frame = +3 Query: 36 SAQXEKEGNGFDTKSDP-------TKA------PPP------IEIPEL---SLDELKEKT 149 SAQ + E +G TK D +KA P P ++ P L S ELK T Sbjct: 6 SAQVKAESSGASTKYDAKDIGSLGSKASSVSVRPSPRTEGEILQSPNLKSFSFAELKSAT 65 Query: 150 DNFGSKALIGEGSYGRVYYAILD----------SGKHLAVKKLDTSADPEPDNEFLTQLS 299 NF +++GEG +G V+ +D +G +AVKKL+ + E+L +++ Sbjct: 66 RNFRPDSVLGEGGFGCVFKGWIDEKSLTASRPGTGLVIAVKKLNQDGW-QGHQEWLAEVN 124 Query: 300 IVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRV 479 + + H + V+++GYC+E RL+ YEF GSL + L R+G+ QP L W R+ Sbjct: 125 YLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENHLF-RRGL-YFQP---LSWKLRL 179 Query: 480 KIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSP 632 K+A+ AAKGLA+LH + +++RD ++SN+LL +Y AK++DF L+ P Sbjct: 180 KVALGAAKGLAFLHSS-ETRVIYRDFKTSNILLDSEYNAKLSDFGLAKDGP 229
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 113 bits (282), Expect = 5e-25 Identities = 56/150 (37%), Positives = 87/150 (58%) Frame = +3 Query: 171 LIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYC 350 +IG+G G VY + + +A+K+L D+ F ++ + R++H + V +LGY Sbjct: 697 IIGKGGAGIVYRGSMPNNVDVAIKRLVGRGTGRSDHGFTAEIQTLGRIRHRHIVRLLGYV 756 Query: 351 VEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKV 530 + L+ YE+ GSL ++LHG KG L W R ++A++AAKGL YLH Sbjct: 757 ANKDTNLLLYEYMPNGSLGELLHGSKG-------GHLQWETRHRVAVEAAKGLCYLHHDC 809 Query: 531 QPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 P I+HRD++S+N+LL D+ A VADF L+ Sbjct: 810 SPLILHRDVKSNNILLDSDFEAHVADFGLA 839
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 109 bits (273), Expect = 6e-24 Identities = 57/165 (34%), Positives = 89/165 (53%) Frame = +3 Query: 126 LDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIV 305 L+++ E T+N K +IG+G++G +Y A L K AVKKL + + ++ + Sbjct: 806 LNKVLEATENLNDKYVIGKGAHGTIYKATLSPDKVYAVKKLVFTGIKNGSVSMVREIETI 865 Query: 306 SRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKI 485 +++H N +++ + + L+ Y + GSLHDILH P LDW R I Sbjct: 866 GKVRHRNLIKLEEFWLRKEYGLILYTYMENGSLHDILH------ETNPPKPLDWSTRHNI 919 Query: 486 AIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A+ A GLAYLH P+IVHRDI+ N+LL D ++DF ++ Sbjct: 920 AVGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIA 964
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 108 bits (271), Expect = 1e-23 Identities = 66/171 (38%), Positives = 94/171 (54%), Gaps = 3/171 (1%) Frame = +3 Query: 126 LDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPE---PDNEFLTQL 296 L E+ T NF + IGEG +G VY A++ + + AVK+L +AD E FLT++ Sbjct: 202 LCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVY-AVKRLKENADLEWTAVKQSFLTEV 260 Query: 297 SIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQR 476 +SR +H N V+ GYC + + Y F GSL D LH + Q P L W QR Sbjct: 261 EQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQ-----TQACPPLSWPQR 315 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 + I + A+ + +LH+ PS++H DI+SSNVLL E K+ DF L+ S Sbjct: 316 LDILLGTARAIQFLHQD-SPSLIHGDIKSSNVLLDERLTPKLGDFGLARFS 365
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 108 bits (269), Expect = 2e-23 Identities = 61/165 (36%), Positives = 89/165 (53%) Frame = +3 Query: 123 SLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSI 302 S EL + T F K +G G G VY +L+ +H+AVKKL+ + F +LS+ Sbjct: 525 SYRELVKATRKF--KVELGRGESGTVYKGVLEDDRHVAVKKLENVRQGK--EVFQAELSV 580 Query: 303 VSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVK 482 + R+ H N V + G+C EG+ RL+ E+ GSL +IL G LDW R Sbjct: 581 IGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANILFSEGG------NILLDWEGRFN 634 Query: 483 IAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 IA+ AKGLAYLH + ++H D++ N+LL + + K+ DF L Sbjct: 635 IALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFGL 679
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 107 bits (268), Expect = 2e-23 Identities = 64/177 (36%), Positives = 101/177 (57%), Gaps = 10/177 (5%) Frame = +3 Query: 132 ELKEKTDNFGSKALIGEGSYGRVYYAILD----------SGKHLAVKKLDTSADPEPDNE 281 +LK T NF +++G+G +G+VY +D SG +A+K+L+ S + E Sbjct: 78 DLKTATKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIKRLN-SESVQGFAE 136 Query: 282 FLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPAL 461 + ++++ + L H N V++LGYC E + L+ YEF GSL L R P P Sbjct: 137 WRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRRN-----DPFP-- 189 Query: 462 DWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSP 632 W R+KI I AA+GLA+LH +Q +++RD ++SN+LL +Y AK++DF L+ P Sbjct: 190 -WDLRIKIVIGAARGLAFLH-SLQREVIYRDFKASNILLDSNYDAKLSDFGLAKLGP 244
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 106 bits (265), Expect = 5e-23 Identities = 65/169 (38%), Positives = 92/169 (54%), Gaps = 3/169 (1%) Frame = +3 Query: 132 ELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPE---PDNEFLTQLSI 302 E+ + T NF + IGEG +G VY A++ + + AVK+L AD E FLT++ Sbjct: 204 EISQGTCNFSEELRIGEGGFGCVYRAVMRNTTY-AVKRLKEEADLEWTMVKQSFLTEVEQ 262 Query: 303 VSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVK 482 +SR +H N V+ GYC E + Y F GSL D LH + Q L W QR+ Sbjct: 263 LSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQ-----TQACSPLSWPQRLD 317 Query: 483 IAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 I + A+ + +LH+ PS++H DI+SSNVLL E K+ DF L+ S Sbjct: 318 ILLGTARAIQFLHQD-SPSLIHGDIKSSNVLLDERLMPKLGDFGLARFS 365
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 99.8 bits (247), Expect = 6e-21 Identities = 64/178 (35%), Positives = 97/178 (54%), Gaps = 9/178 (5%) Frame = +3 Query: 123 SLDELKEKTDNFGSKAL------IGEGSYGRVYYAILDSGKHLAVKKLDTSAD---PEPD 275 S ELK T+NF + + +GEG +G VY +++ +AVKKL D E Sbjct: 169 SFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTT-VAVKKLAAMVDITTEELK 227 Query: 276 NEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGP 455 +F ++ ++++ +HEN VE+LG+ +G+ + Y + GSL D L G P Sbjct: 228 QQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGT------P 281 Query: 456 ALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 L W R KIA AA G+ +LHE +HRDI+S+N+LL E + AK++DF L+ S Sbjct: 282 PLSWHMRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEAFTAKISDFGLARAS 336
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 93.6 bits (231), Expect = 4e-19 Identities = 60/178 (33%), Positives = 94/178 (52%), Gaps = 9/178 (5%) Frame = +3 Query: 123 SLDELKEKTDNFGSKAL------IGEGSYGRVYYAILDSGKHLAVKKLDTSAD---PEPD 275 S ELK T+NF + +GEG +G VY +++ +AVKKL + E Sbjct: 169 SFHELKSITNNFDEQPASAGGNRMGEGGFGVVYKGCVNN-TIVAVKKLGAMVEISTEELK 227 Query: 276 NEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGP 455 +F ++ +++ +HEN VE+LG+ + + + Y + GSL D L G P Sbjct: 228 QQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTP------ 281 Query: 456 ALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 L W R K+A A G+ +LHE +HRDI+S+N+LL +D+ AK++DF L+ S Sbjct: 282 PLSWHTRCKVAQGTANGIRFLHENHH---IHRDIKSANILLDKDFTAKISDFGLARAS 336
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 91.3 bits (225), Expect = 2e-18 Identities = 68/184 (36%), Positives = 98/184 (53%), Gaps = 10/184 (5%) Frame = +3 Query: 99 PPIEIP-------ELSLD--ELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKL- 248 PPI P EL LD ++ + K IG GS+G V+ A G +AVK L Sbjct: 523 PPISQPVPNRANRELGLDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH-GSDVAVKILM 581 Query: 249 DTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRK 428 + E NEFL +++I+ RL+H N V +G + + E+ + GSL+ +LH Sbjct: 582 EQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLH--- 638 Query: 429 GVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVAD 608 GA+ LD +R+ +A D AKG+ YLH + P IVHRD++S N+L+ + Y KV D Sbjct: 639 -KSGAR--EQLDERRRLSMAYDVAKGMNYLHNR-NPPIVHRDLKSPNLLVDKKYTVKVCD 694 Query: 609 FNLS 620 F LS Sbjct: 695 FGLS 698
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 88.2 bits (217), Expect = 2e-17 Identities = 55/153 (35%), Positives = 88/153 (57%), Gaps = 3/153 (1%) Frame = +3 Query: 171 LIGEGSYGRVYYAILDSGKHLAVKKL--DTSADPEPDNEFLTQLSIVSRLKHENFVEMLG 344 +IG GS+G+VY + K +A+K+ +T + F ++SI+ +L H V+ +G Sbjct: 466 IIGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVG 524 Query: 345 YCVEG-NQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 C++ +Q + ++ + GSL +LH +K + LD ++ IA+D AKG+ YLH Sbjct: 525 ACLDDPSQFAIVTQYISGGSLFSLLHEQKRI--------LDLQSKLIIAVDVAKGMEYLH 576 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 QP I+HRD+ S N+LL+ED A VADF S Sbjct: 577 SLTQP-IIHRDLNSHNILLYEDGHAVVADFGES 608
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 88.2 bits (217), Expect = 2e-17 Identities = 55/153 (35%), Positives = 88/153 (57%), Gaps = 3/153 (1%) Frame = +3 Query: 171 LIGEGSYGRVYYAILDSGKHLAVKKL--DTSADPEPDNEFLTQLSIVSRLKHENFVEMLG 344 +IG GS+G+VY + K +A+K+ +T + F ++SI+ +L H V+ +G Sbjct: 467 IIGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVG 525 Query: 345 YCVEG-NQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 C++ +Q + ++ + GSL +LH +K + LD ++ IA+D AKG+ YLH Sbjct: 526 ACLDDPSQFAIVTQYISGGSLFSLLHEQKRI--------LDLQSKLIIAVDVAKGMEYLH 577 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 QP I+HRD+ S N+LL+ED A VADF S Sbjct: 578 SLTQP-IIHRDLNSHNILLYEDGHAVVADFGES 609
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 88.2 bits (217), Expect = 2e-17 Identities = 59/224 (26%), Positives = 100/224 (44%), Gaps = 23/224 (10%) Frame = +3 Query: 30 FPSAQXEKEGNGFDTKSDPTKAPPPIE----------------IPELSLDELKEKTDNFG 161 FPS+ N T + T+ P +E + E+ EL+ TD + Sbjct: 155 FPSSSGVSNSNNNRTSTTATEEIPSLESLGNIHISTVQRAAESLLEIDYAELENATDGWS 214 Query: 162 SKALIGEGSYGRVYYAILDSGKHLAVK-KLDTSADPEPDNEFL------TQLSIVSRLKH 320 +G+G +G VY K L V K+ P D + + +L ++ ++H Sbjct: 215 PDNRLGQGGFGDVYRG---KWKQLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRH 271 Query: 321 ENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAA 500 +N + + GY ++G + + Y+ GSL L K P PAL W QR I++ A Sbjct: 272 DNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKA---QNPLPALTWQQRFSISLGTA 328 Query: 501 KGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSP 632 +G+ +LH ++H DI+ +N+LL + + K+ DF L + P Sbjct: 329 RGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGP 372
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 87.4 bits (215), Expect = 3e-17 Identities = 54/153 (35%), Positives = 88/153 (57%), Gaps = 3/153 (1%) Frame = +3 Query: 171 LIGEGSYGRVYYAILDSGKHLAVKKL--DTSADPEPDNEFLTQLSIVSRLKHENFVEMLG 344 +IG GS+G+VY + K +A+K+ +T + F ++SI+ +L H ++ +G Sbjct: 569 IIGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVG 627 Query: 345 YCV-EGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 C+ + +Q + ++ + GSL +LH +K + LD ++ IA+D AKG+ YLH Sbjct: 628 ACLNDPSQFAIVTQYISGGSLFSLLHEQKRI--------LDLQSKLIIAVDVAKGMEYLH 679 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 QP I+HRD+ S N+LL+ED A VADF S Sbjct: 680 NLTQP-IIHRDLNSHNILLYEDGHAVVADFGES 711
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 85.5 bits (210), Expect = 1e-16 Identities = 57/167 (34%), Positives = 91/167 (54%), Gaps = 1/167 (0%) Frame = +3 Query: 120 LSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLS 299 L+LD++ T K SYG VY A L G ++A++ L + + L + Sbjct: 366 LTLDDVLNATGQVMEKT-----SYGTVYKAKLSDGGNIALRLLREGTCKDRSS-CLPVIR 419 Query: 300 IVSRLKHENFVEMLG-YCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQR 476 + R++HEN V + Y + ++L+ Y++ SLHD+LH K PAL+W +R Sbjct: 420 QLGRIRHENLVPLRAFYQGKRGEKLLIYDYLPNISLHDLLHESK-----PRKPALNWARR 474 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 KIA+ A+GLAYLH + I+H +IRS NVL+ + + A++ +F L Sbjct: 475 HKIALGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGL 521
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 82.4 bits (202), Expect = 1e-15 Identities = 52/155 (33%), Positives = 78/155 (50%), Gaps = 1/155 (0%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDN-EFLTQLSIVSRLKHENFVEMLGYC 350 IG GSYG V+ G +AVKK E EF +++ +S LKH N V +G C Sbjct: 1370 IGLGSYGIVFNGKW-KGVDVAVKKFVKQKLSETQLLEFRAEMAFLSELKHSNIVTFIGAC 1428 Query: 351 VEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKV 530 ++ + E+ MG+L D+L P + + ++K+ AA G+ YLH Sbjct: 1429 IKKPNICIVTEYMRMGNLRDVL--------KNPDIKITFANKLKLLYGAAMGIDYLHSS- 1479 Query: 531 QPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 P IVHRDI+ +N+L+ E + K+ADF + D Sbjct: 1480 NPMIVHRDIKPANILVDEHFNVKIADFGFARIKED 1514 Score = 80.5 bits (197), Expect = 4e-15 Identities = 47/150 (31%), Positives = 81/150 (54%), Gaps = 1/150 (0%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHLAVKKLDTS-ADPEPDNEFLTQLSIVSRLKHENFVEMLGYC 350 +G G YG VY +I G +AVK + + + + F ++ I++ L+H N V + Sbjct: 792 LGTGGYGEVYKSIW-KGTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAAS 850 Query: 351 VEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKV 530 + + EF ++GSL+D+L G + P + + ++K+A A+KG+ +LH Sbjct: 851 TKSPNMCIVMEFMSLGSLYDLL-------GNELIPEIPYALKIKMAYQASKGMHFLHSS- 902 Query: 531 QPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 IVHRD++S N+LL + KV+DF L+ Sbjct: 903 --GIVHRDLKSLNLLLDSKWNVKVSDFGLT 930
>DDR1_HUMAN (Q08345) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) Length = 913 Score = 82.0 bits (201), Expect = 1e-15 Identities = 65/231 (28%), Positives = 102/231 (44%), Gaps = 31/231 (13%) Frame = +3 Query: 21 EHEFPSAQXEKEGNGFDTKSDPTKA----PPPIEIPELSLDELKEKTDNFGSKALIGEGS 188 E + + Q GN + + P A PP ++ P L KEK +GEG Sbjct: 571 EADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRL-RFKEK---------LGEGQ 620 Query: 189 YGRVYYAILDSGKHL-----------------AVKKLDTSADPEPDNEFLTQLSIVSRLK 317 +G V+ +DS + L AVK L A N+FL ++ I+SRLK Sbjct: 621 FGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLK 680 Query: 318 HENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGR-------KGVPG---AQPGPALDW 467 N + +LG CV+ + + ++ G L+ L +G PG A GP + + Sbjct: 681 DPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISY 740 Query: 468 MQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + +A A G+ YL + VHRD+ + N L+ E++ K+ADF +S Sbjct: 741 PMLLHVAAQIASGMRYL---ATLNFVHRDLATRNCLVGENFTIKIADFGMS 788
>DDR1_PANTR (Q7YR43) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (CD167a antigen) Length = 909 Score = 82.0 bits (201), Expect = 1e-15 Identities = 65/231 (28%), Positives = 102/231 (44%), Gaps = 31/231 (13%) Frame = +3 Query: 21 EHEFPSAQXEKEGNGFDTKSDPTKA----PPPIEIPELSLDELKEKTDNFGSKALIGEGS 188 E + + Q GN + + P A PP ++ P L KEK +GEG Sbjct: 567 EADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRL-RFKEK---------LGEGQ 616 Query: 189 YGRVYYAILDSGKHL-----------------AVKKLDTSADPEPDNEFLTQLSIVSRLK 317 +G V+ +DS + L AVK L A N+FL ++ I+SRLK Sbjct: 617 FGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLK 676 Query: 318 HENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGR-------KGVPG---AQPGPALDW 467 N + +LG CV+ + + ++ G L+ L +G PG A GP + + Sbjct: 677 DPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISY 736 Query: 468 MQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + +A A G+ YL + VHRD+ + N L+ E++ K+ADF +S Sbjct: 737 PMLLHVAAQIASGMRYL---ATLNFVHRDLATRNCLVGENFTIKIADFGMS 784
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 80.9 bits (198), Expect = 3e-15 Identities = 58/190 (30%), Positives = 93/190 (48%), Gaps = 11/190 (5%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSG---KHLAVKKLDT 254 P P P+ P L +++ + LIGEG++G+V A++ + A+K L Sbjct: 820 PKPQPEPLNYPVLEWEDITFED-------LIGEGNFGQVIRAMIKKDGLKMNAAIKMLKE 872 Query: 255 SADPEPDNEFLTQLSIVSRLKHE-NFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKG 431 A +F +L ++ +L H N + +LG C +A E+A G+L D L + Sbjct: 873 YASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRV 932 Query: 432 VP-----GAQPGPA--LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDY 590 + + G A L Q ++ A DAA G+ YL EK +HRD+ + NVL+ E+ Sbjct: 933 LETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEK---QFIHRDLAARNVLVGENL 989 Query: 591 RAKVADFNLS 620 +K+ADF LS Sbjct: 990 ASKIADFGLS 999
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 80.9 bits (198), Expect = 3e-15 Identities = 58/190 (30%), Positives = 93/190 (48%), Gaps = 11/190 (5%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSG---KHLAVKKLDT 254 P P P+ P L +++ + LIGEG++G+V A++ + A+K L Sbjct: 818 PKPQPEPLSYPVLEWEDITFED-------LIGEGNFGQVIRAMIKKDGLKMNAAIKMLKE 870 Query: 255 SADPEPDNEFLTQLSIVSRLKHE-NFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKG 431 A +F +L ++ +L H N + +LG C +A E+A G+L D L + Sbjct: 871 YASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRV 930 Query: 432 VP-----GAQPGPA--LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDY 590 + + G A L Q ++ A DAA G+ YL EK +HRD+ + NVL+ E+ Sbjct: 931 LETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEK---QFIHRDLAARNVLVGENL 987 Query: 591 RAKVADFNLS 620 +K+ADF LS Sbjct: 988 ASKIADFGLS 997
>TIE1_HUMAN (P35590) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1138 Score = 80.5 bits (197), Expect = 4e-15 Identities = 58/190 (30%), Positives = 93/190 (48%), Gaps = 11/190 (5%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSG---KHLAVKKLDT 254 P P P+ P L +++ + LIGEG++G+V A++ + A+K L Sbjct: 822 PKLQPEPLSYPVLEWEDITFED-------LIGEGNFGQVIRAMIKKDGLKMNAAIKMLKE 874 Query: 255 SADPEPDNEFLTQLSIVSRLKHE-NFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKG 431 A +F +L ++ +L H N + +LG C +A E+A G+L D L + Sbjct: 875 YASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRV 934 Query: 432 VP-----GAQPGPA--LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDY 590 + + G A L Q ++ A DAA G+ YL EK +HRD+ + NVL+ E+ Sbjct: 935 LETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEK---QFIHRDLAARNVLVGENL 991 Query: 591 RAKVADFNLS 620 +K+ADF LS Sbjct: 992 ASKIADFGLS 1001
>LIMK1_DROME (Q8IR79) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (dLIMK)| Length = 1257 Score = 80.1 bits (196), Expect = 5e-15 Identities = 47/150 (31%), Positives = 81/150 (54%), Gaps = 1/150 (0%) Frame = +3 Query: 174 IGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYC 350 +GEG +G+V+ SG+ + +K+L AD E F+ +++++ L H + ++ +G Sbjct: 407 LGEGFFGKVFKVTHRQSGEVMVLKELH-RADEEAQRNFIKEVAVLRLLDHRHVLKFIGVL 465 Query: 351 VEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKV 530 + + + E+ G L +++H P L W QRV++A D A G++YLH Sbjct: 466 YKDKKLHMVTEYVAGGCLKELIH--------DPAQVLPWPQRVRLARDIACGMSYLHSM- 516 Query: 531 QPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 +I+HRD+ S N L+ ED VADF L+ Sbjct: 517 --NIIHRDLNSMNCLVREDRSVIVADFGLA 544
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 77.8 bits (190), Expect = 3e-14 Identities = 61/196 (31%), Positives = 93/196 (47%), Gaps = 18/196 (9%) Frame = +3 Query: 93 APPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEP 272 APPP P + E+ + K LIG G +G+VY A G+ +AVK DPE Sbjct: 107 APPPSR-PSSPVHVAFERLE---LKELIGAGGFGQVYRATWQ-GQEVAVKA--ARQDPEQ 159 Query: 273 D-----NEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVP 437 D + + + L+H N +E+ G C++ + EFA G+L+ L P Sbjct: 160 DAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAP 219 Query: 438 GAQ-PGPA----LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFE------ 584 + PGP + V A+ A+G+ YLHE+ I+HRD++SSN+LL E Sbjct: 220 DPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDD 279 Query: 585 --DYRAKVADFNLSNQ 626 + K+ DF L+ + Sbjct: 280 ICNKTLKITDFGLARE 295
>TIE2_BRARE (O73791) Tyrosine-protein kinase receptor Tie-2 precursor (EC| 2.7.10.1) Length = 1116 Score = 76.6 bits (187), Expect = 6e-14 Identities = 51/161 (31%), Positives = 85/161 (52%), Gaps = 11/161 (6%) Frame = +3 Query: 171 LIGEGSYGRVYYA-ILDSGKHL--AVKKLDTSADPEPDNEFLTQLSIVSRL-KHENFVEM 338 ++GEG++G+V A I G + AVK++ A + +F +L ++ RL H+N + + Sbjct: 821 VLGEGNFGQVLKARIRKDGLRMDAAVKRMKDYASQDDHRDFAGELEVLCRLGPHKNIIHL 880 Query: 339 LGYCVEGNQRLVAYEFATMGSLHDILHGRKGVP-------GAQPGPALDWMQRVKIAIDA 497 LG C +A EFA G+L D L + + + L Q + + D Sbjct: 881 LGACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPAFAIAHRTASTLSSQQLLAFSADV 940 Query: 498 AKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A+G++YL +K +HRD+ + NVL+ E++ AK+ADF LS Sbjct: 941 ARGMSYLSQK---QFIHRDLAARNVLVGENFVAKIADFGLS 978
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 76.6 bits (187), Expect = 6e-14 Identities = 58/187 (31%), Positives = 93/187 (49%), Gaps = 12/187 (6%) Frame = +3 Query: 96 PPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYA-ILDSGKHL--AVKKLDTSADP 266 P P P L +++K + +IGEG++G+V A I G + A+K++ A Sbjct: 809 PDPTIYPVLDWNDIKFQD-------VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASK 861 Query: 267 EPDNEFLTQLSIVSRLKHE-NFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGA 443 + +F +L ++ +L H N + +LG C +A E+A G+L D L + V Sbjct: 862 DDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLR-KSRVLET 920 Query: 444 QPGPA--------LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAK 599 P A L Q + A D A+G+ YL +K +HRD+ + N+L+ E+Y AK Sbjct: 921 DPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQK---QFIHRDLAARNILVGENYIAK 977 Query: 600 VADFNLS 620 +ADF LS Sbjct: 978 IADFGLS 984
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 76.6 bits (187), Expect = 6e-14 Identities = 45/171 (26%), Positives = 88/171 (51%), Gaps = 1/171 (0%) Frame = +3 Query: 114 PELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQ 293 P++SLD +K + + K + G +G+V S + +KK+ T + NE L + Sbjct: 3 PDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLE 62 Query: 294 LS-IVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWM 470 ++ RL+H V++LG +E + E+ G+L +L + VP + G Sbjct: 63 EGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKG------ 116 Query: 471 QRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSN 623 +I ++A +G+ YLH+K ++H+D++ N+L+ D+ K+AD +++ Sbjct: 117 ---RIIVEAIEGMCYLHDK---GVIHKDLKPENILVDRDFHIKIADLGVAS 161
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 76.6 bits (187), Expect = 6e-14 Identities = 58/187 (31%), Positives = 93/187 (49%), Gaps = 12/187 (6%) Frame = +3 Query: 96 PPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYA-ILDSGKHL--AVKKLDTSADP 266 P P P L +++K + +IGEG++G+V A I G + A+K++ A Sbjct: 811 PDPTIYPVLDWNDIKFQD-------VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASK 863 Query: 267 EPDNEFLTQLSIVSRLKHE-NFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGA 443 + +F +L ++ +L H N + +LG C +A E+A G+L D L + V Sbjct: 864 DDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLR-KSRVLET 922 Query: 444 QPGPA--------LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAK 599 P A L Q + A D A+G+ YL +K +HRD+ + N+L+ E+Y AK Sbjct: 923 DPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQK---QFIHRDLAARNILVGENYVAK 979 Query: 600 VADFNLS 620 +ADF LS Sbjct: 980 IADFGLS 986
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 76.6 bits (187), Expect = 6e-14 Identities = 58/187 (31%), Positives = 93/187 (49%), Gaps = 12/187 (6%) Frame = +3 Query: 96 PPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYA-ILDSGKHL--AVKKLDTSADP 266 P P P L +++K + +IGEG++G+V A I G + A+K++ A Sbjct: 812 PDPTIYPVLDWNDIKFQD-------VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASK 864 Query: 267 EPDNEFLTQLSIVSRLKHE-NFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGA 443 + +F +L ++ +L H N + +LG C +A E+A G+L D L + V Sbjct: 865 DDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLR-KSRVLET 923 Query: 444 QPGPA--------LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAK 599 P A L Q + A D A+G+ YL +K +HRD+ + N+L+ E+Y AK Sbjct: 924 DPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQK---QFIHRDLAARNILVGENYVAK 980 Query: 600 VADFNLS 620 +ADF LS Sbjct: 981 IADFGLS 987
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 76.6 bits (187), Expect = 6e-14 Identities = 52/165 (31%), Positives = 80/165 (48%), Gaps = 3/165 (1%) Frame = +3 Query: 150 DNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENF 329 D+F ++ IG G + V+ + + K++T + + L ++ +++RL H N Sbjct: 57 DDF-TREKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRAN--LLKEMQLMNRLSHPNI 113 Query: 330 VEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGL 509 + +G CV Q E+ G+L +L +P W RVK+A D A GL Sbjct: 114 LRFMGVCVHQGQLHALTEYINSGNLEQLLDSNLYLP---------WTVRVKLAYDIAVGL 164 Query: 510 AYLHEKVQPSIVHRDIRSSNVLLFED---YRAKVADFNLSNQSPD 635 +YLH K I HRD+ S N L+ D Y A VADF L+ + PD Sbjct: 165 SYLHFK---GIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPD 206
>DDR1_RAT (Q63474) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein- Length = 910 Score = 76.3 bits (186), Expect = 7e-14 Identities = 61/231 (26%), Positives = 101/231 (43%), Gaps = 31/231 (13%) Frame = +3 Query: 21 EHEFPSAQXEKEGNGFDTKSDPTKA----PPPIEIPELSLDELKEKTDNFGSKALIGEGS 188 E + + Q GN + + P A PP ++ P L KEK +GEG Sbjct: 568 EADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRL-RFKEK---------LGEGQ 617 Query: 189 YGRVYYAILDSGKHL-----------------AVKKLDTSADPEPDNEFLTQLSIVSRLK 317 +G V+ ++ + L AVK L A N+FL ++ I+SRLK Sbjct: 618 FGEVHLCEVEDPQDLVTSDFPISVQKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLK 677 Query: 318 HENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGR-------KGVPG---AQPGPALDW 467 N + +LG CV+ + + ++ G L+ L +G+PG + GP + + Sbjct: 678 DLNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLENKVTQGLPGDRESDQGPTISY 737 Query: 468 MQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + + A G+ YL + VHRD+ + N L+ E++ K+ADF +S Sbjct: 738 PMLLHVGAQIASGMRYL---ATLNFVHRDLATRNCLVGENFTIKIADFGMS 785
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 76.3 bits (186), Expect = 7e-14 Identities = 60/188 (31%), Positives = 93/188 (49%), Gaps = 13/188 (6%) Frame = +3 Query: 102 PIEIP--ELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVK--KLDTSADPE 269 P EIP EL L+E+ IG G +G+VY A+ G+ +AVK +LD DP Sbjct: 90 PQEIPFHELQLEEI------------IGVGGFGKVYRALW-RGEEVAVKAARLDPEKDPA 136 Query: 270 PDNEFLTQLS-IVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQ 446 E + Q + + L+H N + + G C+ + E+A G+L +L GR+ VP Sbjct: 137 VTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRR-VP--- 192 Query: 447 PGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFE--------DYRAKV 602 P ++W A+ A+G+ YLH I+HRD++S N+L+ E D K+ Sbjct: 193 PHVLVNW------AVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKI 246 Query: 603 ADFNLSNQ 626 DF L+ + Sbjct: 247 TDFGLARE 254
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 76.3 bits (186), Expect = 7e-14 Identities = 50/157 (31%), Positives = 75/157 (47%), Gaps = 3/157 (1%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCV 353 IG G + V+ + + K++T + + L ++ +++RL H N + +G CV Sbjct: 64 IGSGFFSEVFKVRHRASGQVMALKMNTLSSNRAN--MLKEVQLMNRLSHPNILRFMGVCV 121 Query: 354 EGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQ 533 Q E+ G+L +L +P W RVK+A D A GL+YLH K Sbjct: 122 HQGQLHALTEYINSGNLEQLLDSNLHLP---------WTVRVKLAYDIAVGLSYLHFK-- 170 Query: 534 PSIVHRDIRSSNVLLFED---YRAKVADFNLSNQSPD 635 I HRD+ S N L+ D Y A VADF L+ + PD Sbjct: 171 -GIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPD 206
>DDR1_MOUSE (Q03146) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protei Length = 911 Score = 75.9 bits (185), Expect = 1e-13 Identities = 61/231 (26%), Positives = 101/231 (43%), Gaps = 31/231 (13%) Frame = +3 Query: 21 EHEFPSAQXEKEGNGFDTKSDPTKA----PPPIEIPELSLDELKEKTDNFGSKALIGEGS 188 E + + Q GN + + P A PP ++ P L KEK +GEG Sbjct: 569 EADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRL-RFKEK---------LGEGQ 618 Query: 189 YGRVYYAILDSGKHL-----------------AVKKLDTSADPEPDNEFLTQLSIVSRLK 317 +G V+ ++ + L AVK L A N+FL ++ I+SRLK Sbjct: 619 FGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLK 678 Query: 318 HENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGR-------KGVPG---AQPGPALDW 467 N + +LG CV+ + + ++ G L+ L R +G+ G + GP + + Sbjct: 679 DPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISY 738 Query: 468 MQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + + A G+ YL + VHRD+ + N L+ E++ K+ADF +S Sbjct: 739 PMLLHVGAQIASGMRYL---ATLNFVHRDLATRNCLVGENFTIKIADFGMS 786
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 75.9 bits (185), Expect = 1e-13 Identities = 55/181 (30%), Positives = 93/181 (51%), Gaps = 5/181 (2%) Frame = +3 Query: 99 PPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPD- 275 PPI++ E+ EL + +IG G +G+VY A G +AVK DP+ D Sbjct: 132 PPIQLLEIDFAELT-------LEEIIGIGGFGKVYRAFW-IGDEVAVKA--ARHDPDEDI 181 Query: 276 ----NEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGA 443 + + + LKH N + + G C++ + EFA G L+ +L G++ +P Sbjct: 182 SQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR-IP-- 238 Query: 444 QPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSN 623 P ++W A+ A+G+ YLH++ I+HRD++SSN+L+ + KV + +LSN Sbjct: 239 -PDILVNW------AVQIARGMNYLHDEAIVPIIHRDLKSSNILILQ----KVENGDLSN 287 Query: 624 Q 626 + Sbjct: 288 K 288
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 75.9 bits (185), Expect = 1e-13 Identities = 52/165 (31%), Positives = 80/165 (48%), Gaps = 3/165 (1%) Frame = +3 Query: 150 DNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENF 329 D+F ++ IG G + V+ + + K++T + + L ++ +++RL H N Sbjct: 57 DDF-TREKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRAN--LLKEMQLMNRLSHPNI 113 Query: 330 VEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGL 509 + +G CV Q E+ G+L +L +P W RVK+A D A GL Sbjct: 114 LRFMGVCVHQGQLHALTEYINSGNLEQLLDSDLYLP---------WTVRVKLAYDIAVGL 164 Query: 510 AYLHEKVQPSIVHRDIRSSNVLLFED---YRAKVADFNLSNQSPD 635 +YLH K I HRD+ S N L+ D Y A VADF L+ + PD Sbjct: 165 SYLHFK---GIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPD 206
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 75.5 bits (184), Expect = 1e-13 Identities = 55/192 (28%), Positives = 87/192 (45%), Gaps = 3/192 (1%) Frame = +3 Query: 54 EGNGFDTKSDPTKAPPPIEI-PELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKH 230 E NG P P P P + +++ +N IG G +G V+ A Sbjct: 185 EKNGIGNTHIPLTDPMPDNYQPPVHFQDIEINRENIEILNEIGRGFFGSVHRAKWGRSYE 244 Query: 231 LAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQR--LVAYEFATMGSL 404 +A K L +S +F+ + I+ +L+H VE+LG C E L+ E+ GSL Sbjct: 245 VAAKMLQSSKAER--EKFVLEAKIMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSL 302 Query: 405 HDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFE 584 + L G + Q V + + ++G+AYL + +VHRD+R+ N+L+ Sbjct: 303 KEYLK-------TPDGKKTNLNQMVHMMAEISEGMAYLESE---KVVHRDLRADNILVAN 352 Query: 585 DYRAKVADFNLS 620 D KVADF L+ Sbjct: 353 DLTRKVADFGLT 364
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 74.7 bits (182), Expect = 2e-13 Identities = 51/178 (28%), Positives = 84/178 (47%), Gaps = 5/178 (2%) Frame = +3 Query: 102 PIEIPELSL-----DELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADP 266 P+E P++ L D + D+ +G G +G VY + ++ +AVK L A Sbjct: 72 PLERPQIDLSHKTKDMWEISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTL--KAGT 129 Query: 267 EPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQ 446 FL + I+ +L+H +++ C +G + E + GSL D L G G Sbjct: 130 MQPAAFLAEAQIMKKLRHPKLIQLYAVCTQGEPVYIITELMSKGSLLDYLQGEAG----- 184 Query: 447 PGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 AL Q + +A A G+AYL + +HRD+ + N+L+ ++ KVADF L+ Sbjct: 185 ---ALKLPQLIDMAAQVAAGMAYLE---LHNYIHRDLAARNILVGDNNICKVADFGLA 236
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 74.7 bits (182), Expect = 2e-13 Identities = 58/167 (34%), Positives = 83/167 (49%), Gaps = 4/167 (2%) Frame = +3 Query: 123 SLDELKEKTDNFGSKAL---IGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQ 293 SLD L+ +F L +G GSYG V A+ K +AVK+ SA+ + + + Q Sbjct: 5 SLDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRD-KLVAVKEFFASAEQKDIEKEVKQ 63 Query: 294 LSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQ 473 LS R+KH N + + G + EFA GSLH+ LHG K P A+ W + Sbjct: 64 LS---RVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHG-KVKPAYSLAHAMSWAR 119 Query: 474 RVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYR-AKVADF 611 + A+GLAYLH ++HRD++ N+LL R K+ DF Sbjct: 120 Q------CAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDF 160
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 74.7 bits (182), Expect = 2e-13 Identities = 51/183 (27%), Positives = 97/183 (53%), Gaps = 3/183 (1%) Frame = +3 Query: 72 TKSDPTKAPPPIEIPE--LSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKK 245 + S + A IE P L+ +E+ K + ++G G++G V A + K +A+K+ Sbjct: 8 SSSSSSSASEMIEAPSQVLNFEEIDYK--EIEVEEVVGRGAFGVVCKAKWRA-KDVAIKQ 64 Query: 246 LDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGR 425 +++ ++ + F+ +L +SR+ H N V++ G C+ N + E+A GSL+++LHG Sbjct: 65 IESESERKA---FIVELRQLSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGA 119 Query: 426 KGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRA-KV 602 + +P A+ W + ++G+AYLH +++HRD++ N+LL K+ Sbjct: 120 EPLPYYTAAHAMSW------CLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKI 173 Query: 603 ADF 611 DF Sbjct: 174 CDF 176
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 74.3 bits (181), Expect = 3e-13 Identities = 51/183 (27%), Positives = 97/183 (53%), Gaps = 3/183 (1%) Frame = +3 Query: 72 TKSDPTKAPPPIEIPE--LSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKK 245 + S + A IE P L+ +E+ K + ++G G++G V A + K +A+K+ Sbjct: 8 SSSSSSSAGEMIEAPSQVLNFEEIDYK--EIEVEEVVGRGAFGVVCKAKWRA-KDVAIKQ 64 Query: 246 LDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGR 425 +++ ++ + F+ +L +SR+ H N V++ G C+ N + E+A GSL+++LHG Sbjct: 65 IESESERKA---FIVELRQLSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGA 119 Query: 426 KGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRA-KV 602 + +P A+ W + ++G+AYLH +++HRD++ N+LL K+ Sbjct: 120 EPLPYYTAAHAMSW------CLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKI 173 Query: 603 ADF 611 DF Sbjct: 174 CDF 176
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 73.9 bits (180), Expect = 4e-13 Identities = 51/168 (30%), Positives = 80/168 (47%), Gaps = 9/168 (5%) Frame = +3 Query: 144 KTDNFGSKALIGEGSYGRVYYAIL-----DSGKHLAVKKLDTSADPEPDNEFLTQLSIVS 308 K N K +GEG++G+V+ A + K L K A +F + +++ Sbjct: 533 KRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLT 592 Query: 309 RLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDIL--HGRKGVPGAQPGP--ALDWMQR 476 L+HE+ V+ G CVEG+ ++ +E+ G L+ L HG V A+ P L Q Sbjct: 593 NLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQM 652 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + IA A G+ YL VHRD+ + N L+ E+ K+ DF +S Sbjct: 653 LHIAQQIAAGMVYL---ASQHFVHRDLATRNCLVGENLLVKIGDFGMS 697
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 73.9 bits (180), Expect = 4e-13 Identities = 51/168 (30%), Positives = 80/168 (47%), Gaps = 9/168 (5%) Frame = +3 Query: 144 KTDNFGSKALIGEGSYGRVYYAIL-----DSGKHLAVKKLDTSADPEPDNEFLTQLSIVS 308 K N K +GEG++G+V+ A + K L K A +F + +++ Sbjct: 533 KRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLT 592 Query: 309 RLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDIL--HGRKGVPGAQPGP--ALDWMQR 476 L+HE+ V+ G CVEG+ ++ +E+ G L+ L HG V A+ P L Q Sbjct: 593 NLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQM 652 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + IA A G+ YL VHRD+ + N L+ E+ K+ DF +S Sbjct: 653 LHIAQQIAAGMVYL---ASQHFVHRDLATRNCLVGENLLVKIGDFGMS 697
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 73.9 bits (180), Expect = 4e-13 Identities = 51/168 (30%), Positives = 80/168 (47%), Gaps = 9/168 (5%) Frame = +3 Query: 144 KTDNFGSKALIGEGSYGRVYYAIL-----DSGKHLAVKKLDTSADPEPDNEFLTQLSIVS 308 K N K +GEG++G+V+ A + K L K A +F + +++ Sbjct: 534 KRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLT 593 Query: 309 RLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDIL--HGRKGVPGAQPGP--ALDWMQR 476 L+HE+ V+ G CVEG+ ++ +E+ G L+ L HG V A+ P L Q Sbjct: 594 NLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQM 653 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + IA A G+ YL VHRD+ + N L+ E+ K+ DF +S Sbjct: 654 LHIAQQIAAGMVYL---ASQHFVHRDLATRNCLVGENLLVKIGDFGMS 698
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 73.9 bits (180), Expect = 4e-13 Identities = 45/152 (29%), Positives = 73/152 (48%) Frame = +3 Query: 171 LIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYC 350 L+G+G++G VY L +AVK E +FL + I+ + H N V+++G C Sbjct: 568 LLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVC 627 Query: 351 VEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKV 530 + + E + G L +K L Q VK ++DAA G+ YL K Sbjct: 628 TQRQPVYIIMELVSGGDFLTFLRRKK--------DELKLKQLVKFSLDAAAGMLYLESK- 678 Query: 531 QPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 + +HRD+ + N L+ E+ K++DF +S Q Sbjct: 679 --NCIHRDLAARNCLVGENNVLKISDFGMSRQ 708
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 73.9 bits (180), Expect = 4e-13 Identities = 51/166 (30%), Positives = 85/166 (51%), Gaps = 17/166 (10%) Frame = +3 Query: 174 IGEGSYGRVYYAI---LDSGK-----HLAVKKLDTSADPEPDNEFLTQLSIVSRL-KHEN 326 +GEG +G+V A LD K +AVK L + A + ++ ++++ ++ + KH+N Sbjct: 482 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 541 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQ--------PGPALDWMQRVK 482 + +LG C + V E+A+ G+L + L R+ PG + P L + V Sbjct: 542 IINLLGACTQDGPLYVIVEYASKGNLREYLQARR-PPGMEYCYNPTRIPEEQLSFKDLVS 600 Query: 483 IAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A A+G+ YL K +HRD+ + NVL+ ED K+ADF L+ Sbjct: 601 CAYQVARGMEYLASK---KCIHRDLAARNVLVTEDNVMKIADFGLA 643
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 73.9 bits (180), Expect = 4e-13 Identities = 58/198 (29%), Positives = 96/198 (48%), Gaps = 11/198 (5%) Frame = +3 Query: 66 FDTKSDPTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKK 245 F T DP + I ++ E++ + K +IG G + +V+ D G+ +A+K Sbjct: 114 FVTDEDPLQLNVSSAIGDIQPHEIEY--NELDIKEVIGSGGFCKVHRGYYD-GEEVAIKI 170 Query: 246 LDTSADPEPD---NEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDIL 416 + + + + L + + LKHEN + G C+ LV E+A GSL+ IL Sbjct: 171 AHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVM-EYARGGSLNRIL 229 Query: 417 HGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRA 596 G+ +P P ++W AI A+G+ YLH + SI+HRD++SSNVL++E Sbjct: 230 AGK--IP---PDVLVNW------AIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEG 278 Query: 597 --------KVADFNLSNQ 626 K+ DF L+ + Sbjct: 279 NHLQQKTLKITDFGLARE 296
>FGFR1_RAT (Q04589) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 73.2 bits (178), Expect = 6e-13 Identities = 50/165 (30%), Positives = 82/165 (49%), Gaps = 16/165 (9%) Frame = +3 Query: 174 IGEGSYGRVYYAI---LDSGK-----HLAVKKLDTSADPEPDNEFLTQLSIVSRL-KHEN 326 +GEG +G+V A LD K +AVK L + A + ++ ++++ ++ + KH+N Sbjct: 484 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 543 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGV-------PGAQPGPALDWMQRVKI 485 + +LG C + V E+A+ G+L + L R+ P P L V Sbjct: 544 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 603 Query: 486 AIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A A+G+ YL K +HRD+ + NVL+ ED K+ADF L+ Sbjct: 604 AYQVARGMEYLASK---KCIHRDLAARNVLVTEDNVMKIADFGLA 645
>FGFR1_MOUSE (P16092) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 73.2 bits (178), Expect = 6e-13 Identities = 50/165 (30%), Positives = 82/165 (49%), Gaps = 16/165 (9%) Frame = +3 Query: 174 IGEGSYGRVYYAI---LDSGK-----HLAVKKLDTSADPEPDNEFLTQLSIVSRL-KHEN 326 +GEG +G+V A LD K +AVK L + A + ++ ++++ ++ + KH+N Sbjct: 484 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 543 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGV-------PGAQPGPALDWMQRVKI 485 + +LG C + V E+A+ G+L + L R+ P P L V Sbjct: 544 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 603 Query: 486 AIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A A+G+ YL K +HRD+ + NVL+ ED K+ADF L+ Sbjct: 604 AYQVARGMEYLASK---KCIHRDLAARNVLVTEDNVMKIADFGLA 645
>FGFR1_HUMAN (P11362) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 73.2 bits (178), Expect = 6e-13 Identities = 50/165 (30%), Positives = 82/165 (49%), Gaps = 16/165 (9%) Frame = +3 Query: 174 IGEGSYGRVYYAI---LDSGK-----HLAVKKLDTSADPEPDNEFLTQLSIVSRL-KHEN 326 +GEG +G+V A LD K +AVK L + A + ++ ++++ ++ + KH+N Sbjct: 484 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 543 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGV-------PGAQPGPALDWMQRVKI 485 + +LG C + V E+A+ G+L + L R+ P P L V Sbjct: 544 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 603 Query: 486 AIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A A+G+ YL K +HRD+ + NVL+ ED K+ADF L+ Sbjct: 604 AYQVARGMEYLASK---KCIHRDLAARNVLVTEDNVMKIADFGLA 645
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 73.2 bits (178), Expect = 6e-13 Identities = 51/157 (32%), Positives = 81/157 (51%), Gaps = 5/157 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAILDSGKHLAVKK--LDTSADPEPDNEFLT---QLSIVSRLKHENFVE 335 ++G+G+YG VY + G+ +AVK+ LDTS + E+ ++ ++ LKH N V Sbjct: 1066 ILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVA 1125 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C++ N + EF GS+ I++ + GP L M K +G+AY Sbjct: 1126 YLGTCLQENTVSIFMEFVPGGSISSIIN--------RFGP-LPEMVFCKYTKQILQGVAY 1176 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 LHE +VHRDI+ +NV+L K+ DF + + Sbjct: 1177 LHEN---CVVHRDIKGNNVMLMPTGIIKLIDFGCARR 1210
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/166 (29%), Positives = 78/166 (46%), Gaps = 3/166 (1%) Frame = +3 Query: 144 KTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHE 323 + D+F IG G + VY + V K++ P L ++ +++RL+H Sbjct: 53 RVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKL--PSNRGNTLREVQLMNRLRHP 110 Query: 324 NFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAK 503 N + +G CV Q E+ G+L +L + P P L W R+ +A+D A+ Sbjct: 111 NILRFMGVCVHQGQLHALTEYMNGGTLEQLL--------SSPEP-LSWPVRLHLALDIAR 161 Query: 504 GLAYLHEKVQPSIVHRDIRSSNVLLFED---YRAKVADFNLSNQSP 632 GL YLH K + HRD+ S N L+ + + A V DF L+ + P Sbjct: 162 GLRYLHSK---GVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIP 204
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 3/166 (1%) Frame = +3 Query: 144 KTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHE 323 + D+F IG G + VY + V K++ P + L ++ +++RL+H Sbjct: 48 RVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKL--PSNRSNTLREVQLMNRLRHP 105 Query: 324 NFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAK 503 N + +G CV Q E+ G+L +L + P P L W R+ +A+D A+ Sbjct: 106 NILRFMGVCVHQGQLHALTEYMNGGTLEQLL--------SSPEP-LSWPVRLHLALDIAQ 156 Query: 504 GLAYLHEKVQPSIVHRDIRSSNVLLFED---YRAKVADFNLSNQSP 632 GL YLH K + HRD+ S N L+ + + A V DF L+ + P Sbjct: 157 GLRYLHAK---GVFHRDLTSKNCLVRREDGGFTAVVGDFGLAEKIP 199
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 3/166 (1%) Frame = +3 Query: 144 KTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHE 323 + D+F IG G + VY + V K++ P + L ++ +++RL+H Sbjct: 48 RVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKL--PSNRSNTLREVQLMNRLRHP 105 Query: 324 NFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAK 503 N + +G CV Q E+ G+L +L + P P L W R+ +A+D A+ Sbjct: 106 NILRFMGVCVHQGQLHALTEYMNGGTLEQLL--------SSPEP-LSWPVRLHLALDIAQ 156 Query: 504 GLAYLHEKVQPSIVHRDIRSSNVLLFED---YRAKVADFNLSNQSP 632 GL YLH K + HRD+ S N L+ + + A V DF L+ + P Sbjct: 157 GLRYLHAK---GVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIP 199
>INSRR_HUMAN (P14616) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1297 Score = 72.4 bits (176), Expect = 1e-12 Identities = 53/184 (28%), Positives = 89/184 (48%), Gaps = 9/184 (4%) Frame = +3 Query: 96 PPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI---LDSGKH---LAVKKLDTS 257 P E+P + ++E +G+GS+G VY + L++G+ +A+K ++ Sbjct: 969 PDEWEVPREQISIIRE----------LGQGSFGMVYEGLARGLEAGEESTPVALKTVNEL 1018 Query: 258 ADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVP 437 A P EFL + S++ K + V +LG +G LV E T G L L + Sbjct: 1019 ASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEA 1078 Query: 438 GAQPG---PALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVAD 608 PG PAL M +++A + A G+AYL VHRD+ + N ++ +D+ K+ D Sbjct: 1079 ENNPGLPQPALGEM--IQMAGEIADGMAYL---AANKFVHRDLAARNCMVSQDFTVKIGD 1133 Query: 609 FNLS 620 F ++ Sbjct: 1134 FGMT 1137
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 72.4 bits (176), Expect = 1e-12 Identities = 49/169 (28%), Positives = 83/169 (49%), Gaps = 4/169 (2%) Frame = +3 Query: 126 LDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKH----LAVKKLDTSADPEPDNEFLTQ 293 + EK+ + K +IG GSYG VY AI KH +A+K++ D E N+ + + Sbjct: 15 IQRASEKSVQYHLKQVIGRGSYGVVYKAI---NKHTDQVVAIKEVVYENDEEL-NDIMAE 70 Query: 294 LSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQ 473 +S++ L H N V+ G+ + + + E+ GSL ++ ++ L + Sbjct: 71 ISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLI--------SRSSTGLSENE 122 Query: 474 RVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 GL YLH + ++HRDI+++N+LL D K+ADF +S Sbjct: 123 SKTYVTQTLLGLKYLHGE---GVIHRDIKAANILLSADNTVKLADFGVS 168
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) Length = 812 Score = 72.4 bits (176), Expect = 1e-12 Identities = 49/165 (29%), Positives = 82/165 (49%), Gaps = 16/165 (9%) Frame = +3 Query: 174 IGEGSYGRVYYAI---LDSGK-----HLAVKKLDTSADPEPDNEFLTQLSIVSRL-KHEN 326 +GEG +G+V A LD K +AVK L + A + ++ ++++ ++ + KH+N Sbjct: 478 LGEGCFGQVVMAEAIGLDKEKPNKVTKVAVKMLKSDASEKDLSDLISEMEMMKMIGKHKN 537 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGV-------PGAQPGPALDWMQRVKI 485 + +LG C + V E+ + G+L + L R+ P P L + V Sbjct: 538 IINLLGACTQDGPLYVIVEYTSKGNLREYLRARRPPAMEYCYNPTCVPDQLLSFKDLVSC 597 Query: 486 AIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A A+G+ YL K +HRD+ + NVL+ ED K+ADF L+ Sbjct: 598 AYQVARGMDYLASK---KCIHRDLAARNVLVTEDNIMKIADFGLA 639
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 72.4 bits (176), Expect = 1e-12 Identities = 45/153 (29%), Positives = 80/153 (52%), Gaps = 4/153 (2%) Frame = +3 Query: 174 IGEGSYGRVYYA-ILDSGKH---LAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEML 341 +GEG++G+VY +L K +A+K L +A + +F ++ ++S LKH+N V +L Sbjct: 416 LGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCIL 475 Query: 342 GYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 G + + +E+ G LH+ L G +L ++ ++IA+ ++G+ YL Sbjct: 476 GVVLNKEPYCMLFEYMANGDLHEFLISN----SPTEGKSLSQLEFLQIALQISEGMQYLS 531 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 VHRD+ + N L+ E K++DF LS Sbjct: 532 AH---HYVHRDLAARNCLVNEGLVVKISDFGLS 561
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 72.4 bits (176), Expect = 1e-12 Identities = 46/149 (30%), Positives = 74/149 (49%), Gaps = 1/149 (0%) Frame = +3 Query: 177 GEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCV 353 G GS+G VY A + K +AVKKL + + I+S L H N ++ G + Sbjct: 23 GGGSFGSVYRAKWISQDKEVAVKKL---------LKIEKEAEILSVLSHRNIIQFYGVIL 73 Query: 354 EGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQ 533 E + E+A++GSL+D ++ + +D + A D AKG+ YLH + Sbjct: 74 EPPNYGIVTEYASLGSLYDYINSNRS-------EEMDMEHIMTWATDVAKGMHYLHMEAP 126 Query: 534 PSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 ++HRD++S NV++ D K+ DF S Sbjct: 127 VKVIHRDLKSRNVVIAADGVLKICDFGAS 155
>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.11.1)| (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2) Length = 487 Score = 72.4 bits (176), Expect = 1e-12 Identities = 54/182 (29%), Positives = 91/182 (50%), Gaps = 2/182 (1%) Frame = +3 Query: 96 PPPIEIPELSLDEL-KEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPE 269 PP ++ +L D L K+ + F +GEGSYG VY AI ++G+ +A+K++ +D + Sbjct: 9 PPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQ 68 Query: 270 PDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQP 449 E + ++SI+ + + V+ G + + E+ GS+ DI+ R Sbjct: 69 ---EIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN------- 118 Query: 450 GPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 L + I KGL YLH + +HRDI++ N+LL + AK+ADF ++ Q Sbjct: 119 -KTLTEDEIATILQSTLKGLEYLHFMRK---IHRDIKAGNILLNTEGHAKLADFGVAGQL 174 Query: 630 PD 635 D Sbjct: 175 TD 176
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 72.0 bits (175), Expect = 1e-12 Identities = 42/171 (24%), Positives = 86/171 (50%), Gaps = 1/171 (0%) Frame = +3 Query: 114 PELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNE-FLT 290 P++SL+ +K K+ +F A + G +G+V + + +K + + NE L Sbjct: 3 PDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLE 62 Query: 291 QLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWM 470 + +++RL+H V++LG +E + + E+ G+L +L P + G Sbjct: 63 EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKG------ 116 Query: 471 QRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSN 623 +I ++ +G+ YLH K ++H+D++ N+L+ D+ K+AD L++ Sbjct: 117 ---RIILEIIEGMCYLHGK---GVIHKDLKPENILVDNDFHIKIADLGLAS 161
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 72.0 bits (175), Expect = 1e-12 Identities = 52/190 (27%), Positives = 86/190 (45%), Gaps = 3/190 (1%) Frame = +3 Query: 66 FDTKSDPTKAPPPIEIPELSLDE---LKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLA 236 F+TK TK + + + D+ L + + G L+G+G++G VY L +A Sbjct: 33 FNTKQVITKKSGVVLLNPIPKDKKWVLNHEDVSLGE--LLGKGNFGEVYKGTLKDKTPVA 90 Query: 237 VKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDIL 416 VK E +FL + I+ + H N V+++G C + + E G L Sbjct: 91 VKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLSFL 150 Query: 417 HGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRA 596 RK L Q V+ ++D A G+ YL K + +HRD+ + N L+ E+ Sbjct: 151 RKRK--------DELKLKQLVRFSLDVAAGMLYLEGK---NCIHRDLAARNCLVGENNTL 199 Query: 597 KVADFNLSNQ 626 K++DF +S Q Sbjct: 200 KISDFGMSRQ 209
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 72.0 bits (175), Expect = 1e-12 Identities = 46/149 (30%), Positives = 74/149 (49%), Gaps = 1/149 (0%) Frame = +3 Query: 177 GEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCV 353 G GS+G VY A + K +AVKKL + + I+S L H N ++ G + Sbjct: 23 GGGSFGSVYRAKWISQDKEVAVKKL---------LKIEKEAEILSVLSHRNIIQFYGVIL 73 Query: 354 EGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQ 533 E + E+A++GSL+D ++ + +D + A D AKG+ YLH + Sbjct: 74 EPPNYGIVTEYASLGSLYDYINSNRS-------EEMDMDHIMTWATDVAKGMHYLHMEAP 126 Query: 534 PSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 ++HRD++S NV++ D K+ DF S Sbjct: 127 VKVIHRDLKSRNVVIAADGVLKICDFGAS 155
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 71.6 bits (174), Expect = 2e-12 Identities = 50/150 (33%), Positives = 78/150 (52%), Gaps = 1/150 (0%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNE-FLTQLSIVSRLKHENFVEMLGYC 350 +GEG++ V+ G H+A+KKL D E E F+ ++ + + H+N V +G C Sbjct: 114 VGEGAFSEVWEGWW-KGIHVAIKKLKIIGDEEQFKERFIREVQNLKKGNHQNIVMFIGAC 172 Query: 351 VEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKV 530 + + E+ GSL++ILH + P + +K+A D A GL +LH Sbjct: 173 YK--PACIITEYMAGGSLYNILHNPNS---STPKVKYSFPLVLKMATDMALGLLHLHSI- 226 Query: 531 QPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 +IVHRD+ S N+LL E K++DF LS Sbjct: 227 --TIVHRDLTSQNILLDELGNIKISDFGLS 254
>MET_RAT (P97523) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 71.6 bits (174), Expect = 2e-12 Identities = 52/160 (32%), Positives = 76/160 (47%), Gaps = 5/160 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYA-ILDS-GK--HLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +IG G +G VY+ +LDS GK H AVK L+ D E ++FLT+ I+ H N + + Sbjct: 1084 VIGRGHFGCVYHGTLLDSDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSL 1143 Query: 339 LGYCVEG-NQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C+ LV + G L + + P + + + AKG+ Y Sbjct: 1144 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--------DLIGFGLQVAKGMKY 1195 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 L V VHRD+ + N +L E + KVADF L+ D Sbjct: 1196 L---VSKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYD 1232
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 71.6 bits (174), Expect = 2e-12 Identities = 52/168 (30%), Positives = 81/168 (48%), Gaps = 9/168 (5%) Frame = +3 Query: 144 KTDNFGSKALIGEGSYGRVYYAIL-----DSGKHLAVKKLDTSADPEPDNEFLTQLSIVS 308 K N K +GEG++G+V+ A + K L K A +F + +++ Sbjct: 530 KRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLT 589 Query: 309 RLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDIL--HGRKGVPGAQPG-PA-LDWMQR 476 L+HE+ V+ G CVEG+ ++ +E+ G L+ L HG V A+ PA L Q Sbjct: 590 NLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAELTQSQM 649 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + IA A G+ YL VHRD+ + N L+ E+ K+ DF +S Sbjct: 650 LHIAQQIAAGMVYL---ASQHFVHRDLATRNCLVGENLLVKIGDFGMS 694
>TNIK_HUMAN (Q9UKE5) TRAF2 and NCK-interacting kinase (EC 2.7.11.1)| Length = 1360 Score = 71.2 bits (173), Expect = 2e-12 Identities = 52/184 (28%), Positives = 90/184 (48%), Gaps = 8/184 (4%) Frame = +3 Query: 99 PPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPD 275 P + E+ L L++ F L+G G+YG+VY + +G+ A+K +D + D E Sbjct: 6 PARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-- 63 Query: 276 NEFLTQLSIVSRLKHE-NFVEMLGYCVEGN------QRLVAYEFATMGSLHDILHGRKGV 434 E +++++ + H N G ++ N Q + EF GS+ D++ KG Sbjct: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGN 123 Query: 435 PGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFN 614 + +W+ I + +GL++LH Q ++HRDI+ NVLL E+ K+ DF Sbjct: 124 TLKE-----EWI--AYICREILRGLSHLH---QHKVIHRDIKGQNVLLTENAEVKLVDFG 173 Query: 615 LSNQ 626 +S Q Sbjct: 174 VSAQ 177
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 71.2 bits (173), Expect = 2e-12 Identities = 48/178 (26%), Positives = 85/178 (47%), Gaps = 1/178 (0%) Frame = +3 Query: 90 KAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDT-SADP 266 + P P ++ ++D+ + ++ +G G +G V+ + ++ +AVK L S DP Sbjct: 212 QVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDP 271 Query: 267 EPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQ 446 N+FL + I+ L+H +++ C + + E GSL + L Sbjct: 272 ---NDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQN-------D 321 Query: 447 PGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 G + Q+V +A A G+AYL + + +HRD+ + NVL+ E KVADF L+ Sbjct: 322 TGSKIHLTQQVDMAAQVASGMAYLESR---NYIHRDLAARNVLVGEHNIYKVADFGLA 376
>INSRR_MOUSE (Q9WTL4) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1300 Score = 71.2 bits (173), Expect = 2e-12 Identities = 49/158 (31%), Positives = 81/158 (51%), Gaps = 9/158 (5%) Frame = +3 Query: 174 IGEGSYGRVYYAI---LDSGKH---LAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVE 335 +G+GS+G VY + L++G+ +A+K ++ A EFL + S++ K + V Sbjct: 985 LGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVR 1044 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPG---PALDWMQRVKIAIDAAKG 506 +LG +G LV E T G L L + PG PAL M +++A + A G Sbjct: 1045 LLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALSDM--IQMAGEIADG 1102 Query: 507 LAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 +AYL K VHRD+ + N ++ +D+ K+ DF ++ Sbjct: 1103 MAYLAAK---KFVHRDLAARNCMVSQDFTVKIGDFGMT 1137
>INSRR_CAVPO (P14617) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1300 Score = 71.2 bits (173), Expect = 2e-12 Identities = 52/184 (28%), Positives = 89/184 (48%), Gaps = 9/184 (4%) Frame = +3 Query: 96 PPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI---LDSGKH---LAVKKLDTS 257 P E+P + ++E +G+GS+G VY + L++G+ +A+K ++ Sbjct: 969 PDEWEVPREQISIIRE----------LGQGSFGMVYEGVAKGLEAGEESTPVALKTVNEL 1018 Query: 258 ADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVP 437 A P EFL + S++ + + V +LG +G LV E T G L L + Sbjct: 1019 ASPRERIEFLKEASVMKAFQCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEA 1078 Query: 438 GAQPG---PALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVAD 608 PG PAL M +++A + A G+AYL VHRD+ + N ++ +D+ K+ D Sbjct: 1079 ENNPGIPRPALGDM--IQMAGEIADGMAYL---AANKFVHRDLAARNCMVSQDFTVKIGD 1133 Query: 609 FNLS 620 F ++ Sbjct: 1134 FGMT 1137
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 71.2 bits (173), Expect = 2e-12 Identities = 61/212 (28%), Positives = 95/212 (44%), Gaps = 6/212 (2%) Frame = +3 Query: 18 HEHEFPSAQXEKEGNGFDTK---SDPTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGS 188 H H P EG+G T P + P + DE + + K +G G Sbjct: 327 HHHSVPH-----EGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQ 381 Query: 189 YGRVYYAILDS-GKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQ 365 YG VY A+ G +AVK L D +FL + +I+ +KH N V+++G C Sbjct: 382 YGEVYEAVWKRYGNTVAVKTL--KEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPP 439 Query: 366 RLVAYEFATMGSLHDILH--GRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPS 539 + EF + G+L D L GR+ LD + + +A A G++YL + + Sbjct: 440 FYIITEFMSHGNLLDFLRSAGRE---------TLDAVALLYMATQIASGMSYLESR---N 487 Query: 540 IVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 +HRD+ + N L+ ++ KVADF L+ D Sbjct: 488 YIHRDLAARNCLVGDNKLVKVADFGLARLMRD 519
>TNIK_MOUSE (P83510) Traf2 and NCK-interacting kinase (EC 2.7.11.1) (Fragments)| Length = 916 Score = 71.2 bits (173), Expect = 2e-12 Identities = 52/184 (28%), Positives = 90/184 (48%), Gaps = 8/184 (4%) Frame = +3 Query: 99 PPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPD 275 P + E+ L L++ F L+G G+YG+VY + +G+ A+K +D + D E Sbjct: 6 PARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE-- 63 Query: 276 NEFLTQLSIVSRLKHE-NFVEMLGYCVEGN------QRLVAYEFATMGSLHDILHGRKGV 434 E +++++ + H N G ++ N Q + EF GS+ D++ KG Sbjct: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGN 123 Query: 435 PGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFN 614 + +W+ I + +GL++LH Q ++HRDI+ NVLL E+ K+ DF Sbjct: 124 TLKE-----EWI--AYICREILRGLSHLH---QHKVIHRDIKGQNVLLTENAEVKLVDFG 173 Query: 615 LSNQ 626 +S Q Sbjct: 174 VSAQ 177
>MET_MOUSE (P16056) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1379 Score = 71.2 bits (173), Expect = 2e-12 Identities = 50/160 (31%), Positives = 74/160 (46%), Gaps = 5/160 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAIL--DSGK--HLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +IG G +G VY+ L + GK H AVK L+ D E ++FLT+ I+ H N + + Sbjct: 1081 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSL 1140 Query: 339 LGYCVEG-NQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C+ LV + G L + + P + + + AKG+ Y Sbjct: 1141 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--------DLIGFGLQVAKGMKY 1192 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 L K VHRD+ + N +L E + KVADF L+ D Sbjct: 1193 LASK---KFVHRDLAARNCMLDEKFTVKVADFGLARDMYD 1229
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 71.2 bits (173), Expect = 2e-12 Identities = 48/155 (30%), Positives = 80/155 (51%), Gaps = 1/155 (0%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGK-HLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYC 350 IG G++G VY A L S K +AVK + E +FL + I+ + H N V+++G C Sbjct: 1069 IGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGIC 1128 Query: 351 VEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKV 530 V+ ++ E GSL + + RK G L Q++ + DAA G+ YL K Sbjct: 1129 VQKQPIMIVMELVLGGSL--LTYLRKNSNG------LTTRQQMGMCRDAAAGMRYLESK- 1179 Query: 531 QPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 + +HRD+ + N L+ ++ K++DF +S + + Sbjct: 1180 --NCIHRDLAARNCLVDLEHSVKISDFGMSREEEE 1212
>INSR_XENLA (Q9PVZ4) Insulin receptor precursor (EC 2.7.10.1) (IR) (Xe-InsR)| (XTK-1b) [Contains: Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1362 Score = 70.9 bits (172), Expect = 3e-12 Identities = 52/211 (24%), Positives = 93/211 (44%), Gaps = 7/211 (3%) Frame = +3 Query: 9 RREHEHEFPSAQXEKEGNGFDTKSDPTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGS 188 +++ + E P+ N + P E+P ++ L+E +G+GS Sbjct: 973 QKKKDAEGPAGPLYTSSNPEYLSASEVYIPDEWEVPRDKINLLRE----------LGQGS 1022 Query: 189 YGRVYYAIL------DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYC 350 +G VY I + +AVK ++ SA EFL + S++ + V +LG Sbjct: 1023 FGMVYEGIAKDIIKGEPEVRVAVKTVNESASLRERIEFLNEASVMKAFNCHHVVRLLGVV 1082 Query: 351 VEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQR-VKIAIDAAKGLAYLHEK 527 +G LV E G L L + PG ++ +++A + + G+AYL+ K Sbjct: 1083 SKGQPTLVIMELMAHGDLKSYLRSLRPDAENNPGRLAPTLKEIIQMAAEISDGMAYLNAK 1142 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 VHRD+ + N ++ +DY K+ DF ++ Sbjct: 1143 ---KFVHRDLAARNCMVADDYAVKIGDFGMT 1170
>FGFR3_HUMAN (P22607) Fibroblast growth factor receptor 3 precursor (EC| 2.7.10.1) (FGFR-3) (CD333 antigen) Length = 806 Score = 70.5 bits (171), Expect = 4e-12 Identities = 49/166 (29%), Positives = 82/166 (49%), Gaps = 17/166 (10%) Frame = +3 Query: 174 IGEGSYGRVYYAI---LDSGKH-----LAVKKLDTSADPEPDNEFLTQLSIVSRL-KHEN 326 +GEG +G+V A +D + +AVK L A + ++ ++++ ++ + KH+N Sbjct: 478 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 537 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQ--------PGPALDWMQRVK 482 + +LG C +G V E+A G+L + L R+ PG P L + V Sbjct: 538 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARR-PPGLDYSFDTCKPPEEQLTFKDLVS 596 Query: 483 IAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A A+G+ YL +HRD+ + NVL+ ED K+ADF L+ Sbjct: 597 CAYQVARGMEYL---ASQKCIHRDLAARNVLVTEDNVMKIADFGLA 639
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 70.5 bits (171), Expect = 4e-12 Identities = 59/205 (28%), Positives = 86/205 (41%), Gaps = 10/205 (4%) Frame = +3 Query: 21 EHEFPSAQXEKEGNGFDTKSDPTKAPPPIEIPELSLDEL-------KEKTDNFGSKALIG 179 E + P + D+K T P ++ L+ D L + TD+F I Sbjct: 158 EEDAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKIS 217 Query: 180 EGSYGRVYYAILDSGKHLAVKKLDTSADPEP---DNEFLTQLSIVSRLKHENFVEMLGYC 350 +G++ VY GK KKL +A P + F +L I R H N + +LG+C Sbjct: 218 QGTFADVYRGHRH-GKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFC 276 Query: 351 VEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKV 530 Y + GSL D L G+ G L W QRV I + YLH Sbjct: 277 AARQFHSFIYPYMANGSLQDRLQGQGG------SDPLPWPQRVSICSGLLCAVEYLHGL- 329 Query: 531 QPSIVHRDIRSSNVLLFEDYRAKVA 605 I+H +++SSNVLL ++ K+A Sbjct: 330 --EIIHSNVKSSNVLLDQNLTPKLA 352
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 70.5 bits (171), Expect = 4e-12 Identities = 53/198 (26%), Positives = 90/198 (45%), Gaps = 7/198 (3%) Frame = +3 Query: 48 EKEGNGFDTKSDPTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILD--- 218 E++ ++ PT P + L +++ +GEG +G+V D Sbjct: 848 EEQNPDIVSEKQPTTEVDPTHFEKRFLKRIRD----------LGEGHFGKVELCRYDPEG 897 Query: 219 --SGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVE--GNQRLVAYEF 386 +G+ +AVK L + + ++ I+ L HEN V+ G C+E GN + EF Sbjct: 898 DNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEF 957 Query: 387 ATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSS 566 GSL + L K ++ Q++K AI KG+ YL + VHRD+ + Sbjct: 958 LPSGSLKEYLPKNKN--------KINLKQQLKYAIQICKGMDYLGSR---QYVHRDLAAR 1006 Query: 567 NVLLFEDYRAKVADFNLS 620 NVL+ +++ K+ DF L+ Sbjct: 1007 NVLVESEHQVKIGDFGLT 1024
>MUSK_RAT (Q62838) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 70.1 bits (170), Expect = 5e-12 Identities = 50/173 (28%), Positives = 80/173 (46%), Gaps = 24/173 (13%) Frame = +3 Query: 174 IGEGSYGRVYYAIL------DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVE 335 IGEG++GRV+ A + +AVK L A + +F + ++++ + N V+ Sbjct: 580 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVK 639 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDIL------------------HGRKGVPGAQPGPAL 461 +LG C G + +E+ G L++ L R PG P L Sbjct: 640 LLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGP---PPL 696 Query: 462 DWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 +++ IA A G+AYL E+ VHRD+ + N L+ E+ K+ADF LS Sbjct: 697 SCAEQLCIARQVAAGMAYLSER---KFVHRDLATRNCLVGENMVVKIADFGLS 746
>TAOK1_RAT (O88664) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 70.1 bits (170), Expect = 5e-12 Identities = 53/177 (29%), Positives = 89/177 (50%), Gaps = 3/177 (1%) Frame = +3 Query: 108 EIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDN-- 278 EI EL E EK F IG GS+G VY+A + + + +A+KK+ S + Sbjct: 14 EIAELFFKEDPEKL--FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQ 71 Query: 279 EFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPA 458 + + ++ + R+KH N +E G + + + E+ +GS D+L K Sbjct: 72 DIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYC-LGSASDLLEVHK--------KP 122 Query: 459 LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 L ++ I A +GLAYLH +++HRDI++ N+LL E + K+ADF ++ + Sbjct: 123 LQEVEIAAITHGALQGLAYLHSH---TMIHRDIKAGNILLTEPGQVKLADFGSASMA 176
>TAOK1_MOUSE (Q5F2E8) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 70.1 bits (170), Expect = 5e-12 Identities = 53/177 (29%), Positives = 89/177 (50%), Gaps = 3/177 (1%) Frame = +3 Query: 108 EIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDN-- 278 EI EL E EK F IG GS+G VY+A + + + +A+KK+ S + Sbjct: 14 EIAELFFKEDPEKL--FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQ 71 Query: 279 EFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPA 458 + + ++ + R+KH N +E G + + + E+ +GS D+L K Sbjct: 72 DIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYC-LGSASDLLEVHK--------KP 122 Query: 459 LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 L ++ I A +GLAYLH +++HRDI++ N+LL E + K+ADF ++ + Sbjct: 123 LQEVEIAAITHGALQGLAYLHSH---TMIHRDIKAGNILLTEPGQVKLADFGSASMA 176
>TAOK1_HUMAN (Q7L7X3) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B) Length = 1001 Score = 70.1 bits (170), Expect = 5e-12 Identities = 53/177 (29%), Positives = 89/177 (50%), Gaps = 3/177 (1%) Frame = +3 Query: 108 EIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDN-- 278 EI EL E EK F IG GS+G VY+A + + + +A+KK+ S + Sbjct: 14 EIAELFFKEDPEKL--FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQ 71 Query: 279 EFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPA 458 + + ++ + R+KH N +E G + + + E+ +GS D+L K Sbjct: 72 DIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYC-LGSASDLLEVHK--------KP 122 Query: 459 LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 L ++ I A +GLAYLH +++HRDI++ N+LL E + K+ADF ++ + Sbjct: 123 LQEVEIAAITHGALQGLAYLHSH---TMIHRDIKAGNILLTEPGQVKLADFGSASMA 176
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 70.1 bits (170), Expect = 5e-12 Identities = 46/149 (30%), Positives = 71/149 (47%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCV 353 +G G +G V+ + + +AVK L EFL + SI+ RL+H +++ C Sbjct: 246 LGAGQFGEVWEGLWNGTTSVAVKTLKPGTMSV--EEFLQEASIMKRLRHPKLIQLYAVCT 303 Query: 354 EGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQ 533 + + E GSL + L G GV L Q V +A A G++YL Q Sbjct: 304 KEEPIYIVTELMKYGSLLEYLRGEDGV--------LKIEQLVDVAAQVASGMSYLE---Q 352 Query: 534 PSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + +HRD+ + N+L+ E KVADF L+ Sbjct: 353 QNYIHRDLAARNILVGEHGICKVADFGLA 381
>CC2H3_TRYBB (P54666) Cell division control protein 2 homolog 3 (EC 2.7.11.22)| Length = 311 Score = 70.1 bits (170), Expect = 5e-12 Identities = 53/166 (31%), Positives = 87/166 (52%), Gaps = 4/166 (2%) Frame = +3 Query: 135 LKEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKK--LDTSADPEPDNEFLTQLSIV 305 LK++ D + ++GEG+YG VY A+ +G+ +A+KK LD + + P L ++SI+ Sbjct: 16 LKDQFDRYNRMDILGEGTYGVVYRAVDRATGQIVALKKVRLDRTDEGIPQTA-LREVSIL 74 Query: 306 SRLKHENFVEMLGY-CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVK 482 + H N V +L C +G L+ +E+ HD+ + GA G L K Sbjct: 75 QEIHHPNIVNLLDVICADGKLYLI-FEYVD----HDLKKALEKRGGAFTGTTLK-----K 124 Query: 483 IAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 I +GL++ H IVHRD++ +N+L+ D K+ADF L+ Sbjct: 125 IIYQLLEGLSFCHRH---RIVHRDLKPANILVTTDNSVKIADFGLA 167
>MUSK_HUMAN (O15146) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 869 Score = 70.1 bits (170), Expect = 5e-12 Identities = 50/171 (29%), Positives = 80/171 (46%), Gaps = 22/171 (12%) Frame = +3 Query: 174 IGEGSYGRVYYAIL------DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVE 335 IGEG++GRV+ A + +AVK L A + +F + ++++ + N V+ Sbjct: 581 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVK 640 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDILHG----------------RKGVPGAQPGPALDW 467 +LG C G + +E+ G L++ L R V P P L Sbjct: 641 LLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGP-PPLSC 699 Query: 468 MQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 +++ IA A G+AYL E+ VHRD+ + N L+ E+ K+ADF LS Sbjct: 700 AEQLCIARQVAAGMAYLSER---KFVHRDLATRNCLVGENMVVKIADFGLS 747
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 70.1 bits (170), Expect = 5e-12 Identities = 54/186 (29%), Positives = 91/186 (48%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ +A +G+G +G V+ + +A+K L Sbjct: 245 PTSKP---QTQGLAKDAWEIPRESLRLEAKLGQGCFGEVWMGTWNDTTRVAIKTLKPGTM 301 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V++ Y V + + + E+ + GSL D L G Sbjct: 302 SPEA---FLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVIEYMSKGSLLDFLKG----- 351 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V +A A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 352 --EMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 406 Query: 618 SNQSPD 635 + D Sbjct: 407 ARLIED 412
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 70.1 bits (170), Expect = 5e-12 Identities = 54/186 (29%), Positives = 91/186 (48%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ +A +G+G +G V+ + +A+K L Sbjct: 245 PTSKP---QTQGLAKDAWEIPRESLRLEAKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 301 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V++ Y V + + + E+ + GSL D L G Sbjct: 302 SPEA---FLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVIEYMSKGSLLDFLKG----- 351 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V +A A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 352 --EMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 406 Query: 618 SNQSPD 635 + D Sbjct: 407 ARLIED 412
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 70.1 bits (170), Expect = 5e-12 Identities = 52/155 (33%), Positives = 82/155 (52%), Gaps = 2/155 (1%) Frame = +3 Query: 171 LIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYC 350 +IG+G +G V G +AVK + A + FL + S++++L+H N V++LG Sbjct: 200 IIGKGEFGDVMLGDY-RGNKVAVKCIKNDATAQA---FLAEASVMTQLRHSNLVQLLGVI 255 Query: 351 VEGNQRL-VAYEFATMGSLHDILHGR-KGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHE 524 VE L + E+ GSL D L R + V G G L +K ++D + + YL Sbjct: 256 VEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLG---GDCL-----LKFSLDVCEAMEYLEA 307 Query: 525 KVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 + VHRD+ + NVL+ ED AKV+DF L+ ++ Sbjct: 308 N---NFVHRDLAARNVLVSEDNIAKVSDFGLTKEA 339
>INSR_DROME (P09208) Insulin-like receptor precursor (EC 2.7.10.1) (DIR) (DInr)| (dIRH) [Contains: Insulin-like receptor alpha subunit; Insulin-like receptor beta 1 subunit; Insulin-like receptor beta 2 subunit] Length = 2144 Score = 70.1 bits (170), Expect = 5e-12 Identities = 48/185 (25%), Positives = 83/185 (44%), Gaps = 21/185 (11%) Frame = +3 Query: 129 DELKEKTDNFGSKALIGEGSYGRVYYAILDS------GKHLAVKKLDTSADPEPDNEFLT 290 D+ + +N A +G+GS+G VY IL S + A+K ++ +A FL+ Sbjct: 1362 DDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLS 1421 Query: 291 QLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWM 470 + S++ + V +LG C G LV E G L L + P + + ++ Sbjct: 1422 EASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHR--PEERDEAMMTYL 1479 Query: 471 QRV---------------KIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVA 605 R+ ++AI+ A G+AYL K VHRD+ + N ++ +D K+ Sbjct: 1480 NRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAK---KFVHRDLAARNCMVADDLTVKIG 1536 Query: 606 DFNLS 620 DF ++ Sbjct: 1537 DFGMT 1541
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 69.7 bits (169), Expect = 7e-12 Identities = 46/151 (30%), Positives = 74/151 (49%), Gaps = 1/151 (0%) Frame = +3 Query: 171 LIGEGSYGR-VYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGY 347 ++G+G +G+ + +GK + +K+L D E FLT++ ++ L H N ++ +G Sbjct: 336 VLGKGFFGQAIKVTHKATGKVMVMKEL-IRCDEETQKTFLTEVKVMRSLDHPNVLKFIGV 394 Query: 348 CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 + + + E+ G+L D L P W Q+V+ A A G+AYLH Sbjct: 395 LYKDKKLNLLTEYIEGGTLKDFLRSMDPFP---------WQQKVRFAKGIASGMAYLHSM 445 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 I+HRD+ S N L+ D VADF LS Sbjct: 446 ---CIIHRDLNSHNCLIKLDKTVVVADFGLS 473
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 69.7 bits (169), Expect = 7e-12 Identities = 44/155 (28%), Positives = 71/155 (45%), Gaps = 1/155 (0%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKH-LAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYC 350 IG G++G V+ L + +AVK + PE +FL + I+ + H N V ++G C Sbjct: 618 IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQCNHPNIVRLIGVC 677 Query: 351 VEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKV 530 + + E G L + GP L + +K+ +AA G+ YL K Sbjct: 678 TQKQPIYIVMELVQGGDFLSFLRSK--------GPRLKMKKLIKMMENAAAGMEYLESK- 728 Query: 531 QPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 +HRD+ + N L+ E K++DF +S Q D Sbjct: 729 --HCIHRDLAARNCLVTEKNTLKISDFGMSRQEED 761
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 69.7 bits (169), Expect = 7e-12 Identities = 47/155 (30%), Positives = 76/155 (49%), Gaps = 6/155 (3%) Frame = +3 Query: 174 IGEGSYGRVYYAILD----SGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEML 341 +GEG +G+V D +G+ +AVK L + + ++ I+ L HEN V+ Sbjct: 870 LGEGHFGKVELCRYDPEDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYK 929 Query: 342 GYCVE--GNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 G C E GN + EF GSL + L K ++ Q++K A+ KG+ Y Sbjct: 930 GICTEDGGNGIKLIMEFLPSGSLKEYLPKNKN--------KINLKQQLKYAVQICKGMDY 981 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 L + VHRD+ + NVL+ +++ K+ DF L+ Sbjct: 982 LGSR---QYVHRDLAARNVLVESEHQVKIGDFGLT 1013
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 69.7 bits (169), Expect = 7e-12 Identities = 44/155 (28%), Positives = 71/155 (45%), Gaps = 1/155 (0%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKH-LAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYC 350 IG G++G V+ L + +AVK + PE +FL + I+ + H N V ++G C Sbjct: 278 IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQYNHPNIVRLIGVC 337 Query: 351 VEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKV 530 + + E G L + GP L + +K+ +AA G+ YL K Sbjct: 338 TQKQPIYIVMELVQGGDFLSFLRSK--------GPHLKMKELIKMMENAAAGMEYLESK- 388 Query: 531 QPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 +HRD+ + N L+ E K++DF +S Q D Sbjct: 389 --HCIHRDLAARNCLVTEKNTLKISDFGMSRQEED 421
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 69.7 bits (169), Expect = 7e-12 Identities = 61/199 (30%), Positives = 91/199 (45%), Gaps = 20/199 (10%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRV---YYAILDSGKHLAVKKL-- 248 P PPP ++P S E+ FG IG+G +G V Y+ D +A+K + Sbjct: 1267 PPPPPPPPQLPVRSEYEIDFNELEFGQT--IGKGFFGEVKRGYWRETD----VAIKIIYR 1320 Query: 249 DTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQ--RLVAYEFATMGSLHDILHG 422 D F ++ I+S+L+H N V+ LG C G + + E+ GSL L Sbjct: 1321 DQFKTKSSLVMFQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTD 1380 Query: 423 RKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLL-------- 578 + P R+K+A+D AKG+ YLH P I+HRD+ S N+LL Sbjct: 1381 HFNLLEQNP------HIRLKLALDIAKGMNYLHGWT-PPILHRDLSSRNILLDHNIDPKN 1433 Query: 579 -----FEDYRAKVADFNLS 620 +D + K++DF LS Sbjct: 1434 PVVSSRQDIKCKISDFGLS 1452
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 69.7 bits (169), Expect = 7e-12 Identities = 48/151 (31%), Positives = 75/151 (49%), Gaps = 1/151 (0%) Frame = +3 Query: 171 LIGEGSYGR-VYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGY 347 ++G+G +G+ + +GK + +K+L D E FLT++ ++ L H N ++ +G Sbjct: 336 VLGKGFFGQAIKVTHKATGKVMVMKEL-IRCDEETQKTFLTEVKVMRSLDHPNVLKFIGV 394 Query: 348 CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 + + + E+ G+L D L A P P W Q+V A A G+AYLH Sbjct: 395 LYKDKKLNLLTEYIEGGTLKDFLR------NADPFP---WQQKVSFAKGIASGMAYLHSM 445 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 I+HRD+ S N L+ D VADF LS Sbjct: 446 ---CIIHRDLNSHNCLIKLDKTVVVADFGLS 473
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 69.7 bits (169), Expect = 7e-12 Identities = 55/186 (29%), Positives = 90/186 (48%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + LS D + D+ + +G+G +G V+ + +A+K L Sbjct: 244 PTAKP---QTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 300 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V++ Y V + + + E+ + GSL D L G Sbjct: 301 SPEA---FLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVTEYMSKGSLLDFLKG----- 350 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V +A A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 351 --EMGRYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 405 Query: 618 SNQSPD 635 + D Sbjct: 406 ARLIED 411
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 69.7 bits (169), Expect = 7e-12 Identities = 55/186 (29%), Positives = 90/186 (48%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + LS D + D+ + +G+G +G V+ + +A+K L Sbjct: 244 PTAKP---QTQGLSRDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 300 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V++ Y V + + + E+ + GSL D L G Sbjct: 301 SPEA---FLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVTEYISKGSLLDFLKG----- 350 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V +A A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 351 --EMGRYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 405 Query: 618 SNQSPD 635 + D Sbjct: 406 ARLIED 411
>STK3_HUMAN (Q13188) Serine/threonine-protein kinase 3 (EC 2.7.11.1)| (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1) Length = 491 Score = 69.3 bits (168), Expect = 9e-12 Identities = 54/181 (29%), Positives = 90/181 (49%), Gaps = 2/181 (1%) Frame = +3 Query: 99 PPIEIPELSLDEL-KEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEP 272 P ++ +LS D L K+ + F +GEGSYG V+ AI +SG+ +A+K++ +D + Sbjct: 7 PKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ- 65 Query: 273 DNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPG 452 E + ++SI+ + V+ G + + E+ GS+ DI+ R Sbjct: 66 --EIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN-------- 115 Query: 453 PALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSP 632 L + I KGL YLH + +HRDI++ N+LL + AK+ADF ++ Q Sbjct: 116 KTLIEDEIATILKSTLKGLEYLHFMRK---IHRDIKAGNILLNTEGHAKLADFGVAGQLT 172 Query: 633 D 635 D Sbjct: 173 D 173
>FGFR3_MOUSE (Q61851) Fibroblast growth factor receptor 3 precursor (EC| 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) Length = 801 Score = 69.3 bits (168), Expect = 9e-12 Identities = 49/166 (29%), Positives = 81/166 (48%), Gaps = 17/166 (10%) Frame = +3 Query: 174 IGEGSYGRVYYAI---LDSGKH-----LAVKKLDTSADPEPDNEFLTQLSIVSRL-KHEN 326 +GEG +G+V A +D + +AVK L A + ++ ++++ ++ + KH+N Sbjct: 472 LGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 531 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQ--------PGPALDWMQRVK 482 + +LG C +G V E+A G+L + L R+ PG P L V Sbjct: 532 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARR-PPGMDYSFDACRLPEEQLTCKDLVS 590 Query: 483 IAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A A+G+ YL +HRD+ + NVL+ ED K+ADF L+ Sbjct: 591 CAYQVARGMEYL---ASQKCIHRDLAARNVLVTEDNVMKIADFGLA 633
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 69.3 bits (168), Expect = 9e-12 Identities = 49/160 (30%), Positives = 74/160 (46%), Gaps = 5/160 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAIL--DSGK--HLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +IG G +G VY+ L + GK H AVK L+ D ++FLT+ I+ H N + + Sbjct: 1084 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1143 Query: 339 LGYCVEGN-QRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C+ LV + G L + + P + + + AKG+ Y Sbjct: 1144 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--------DLIGFGLQVAKGMKY 1195 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 L K VHRD+ + N +L E++ KVADF L+ D Sbjct: 1196 LASK---KFVHRDLAARNCMLDENFTVKVADFGLARDMYD 1232
>ROR2_DROME (Q9V6K3) Tyrosine-protein kinase transmembrane receptor Ror2| precursor (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase) Length = 724 Score = 69.3 bits (168), Expect = 9e-12 Identities = 51/182 (28%), Positives = 85/182 (46%), Gaps = 11/182 (6%) Frame = +3 Query: 114 PELSLDELKEKTDNFGSKALIGEGSYGRVYYA-----ILDSGKHL-AVKKLDTSADPEPD 275 P L++L+ + +G+G++GRV+ A + D L AVK L A + Sbjct: 427 PNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQ 486 Query: 276 NEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGP 455 +F + +++ H N V +LG C G + +E+ G L + L Q P Sbjct: 487 MDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQ-AP 545 Query: 456 ALDWMQ-----RVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 D +Q +++A + A G+ YL E+ VHRD+ + N L+ E K+ADF LS Sbjct: 546 TQDRLQLNELHLLQMAANIAAGMLYLSER---KFVHRDLATRNCLINEHMAVKIADFGLS 602 Query: 621 NQ 626 ++ Sbjct: 603 HK 604
>IGF1R_XENLA (O73798) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (xIGF-1R) (xIGFR) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1358 Score = 69.3 bits (168), Expect = 9e-12 Identities = 45/158 (28%), Positives = 78/158 (49%), Gaps = 9/158 (5%) Frame = +3 Query: 174 IGEGSYGRVYYAIL------DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVE 335 +G+GS+G VY I ++ +A+K ++ +A EFL + S++ + V Sbjct: 1001 LGQGSFGMVYEGIAKGVVKDEAETKVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVR 1060 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDILHGRK---GVPGAQPGPALDWMQRVKIAIDAAKG 506 +LG +G LV E T G L L + QP P+L M +++A + A G Sbjct: 1061 LLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTESNSGQPTPSLKKM--IQMAGEIADG 1118 Query: 507 LAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 ++YL+ VHRD+ + N ++ ED+ K+ DF ++ Sbjct: 1119 MSYLNAN---KFVHRDLAARNCMVTEDFTVKIGDFGMT 1153
>DDR2_MOUSE (Q62371) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 854 Score = 69.3 bits (168), Expect = 9e-12 Identities = 49/195 (25%), Positives = 87/195 (44%), Gaps = 25/195 (12%) Frame = +3 Query: 111 IPELSLDELKEK---TDNFGSKAL-----IGEGSYGRVYYAILDSGKH------------ 230 +P +++D L K + F K L +GEG +G V+ ++ + Sbjct: 540 VPAVTMDLLSGKDVAVEEFPRKLLAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSA 599 Query: 231 -----LAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATM 395 +AVK L A+ N+FL ++ I+SRLK N + +L C+ + + E+ Sbjct: 600 NQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMEN 659 Query: 396 GSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVL 575 G L+ L + + + + +A A G+ YL + VHRD+ + N L Sbjct: 660 GDLNQFLSRHEPLSSCSSDATVSYANLKFMATQIASGMKYLSSL---NFVHRDLATRNCL 716 Query: 576 LFEDYRAKVADFNLS 620 + ++Y K+ADF +S Sbjct: 717 VGKNYTIKIADFGMS 731
>MUSK_MOUSE (Q61006) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 69.3 bits (168), Expect = 9e-12 Identities = 50/173 (28%), Positives = 79/173 (45%), Gaps = 24/173 (13%) Frame = +3 Query: 174 IGEGSYGRVYYAIL------DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVE 335 IGEG++GRV+ A + +AVK L A + +F + ++++ + N V+ Sbjct: 580 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVK 639 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDIL------------------HGRKGVPGAQPGPAL 461 +LG C G + +E+ G L++ L R PG P L Sbjct: 640 LLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGP---PPL 696 Query: 462 DWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 +++ IA A G+AYL E+ VHRD+ + N L+ E K+ADF LS Sbjct: 697 SCAEQLCIARQVAAGMAYLSER---KFVHRDLATRNCLVGETMVVKIADFGLS 746
>TAOK3_XENLA (Q6DD27) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 896 Score = 68.9 bits (167), Expect = 1e-11 Identities = 48/155 (30%), Positives = 81/155 (52%), Gaps = 3/155 (1%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHL-AVKKLDTSADP--EPDNEFLTQLSIVSRLKHENFVEMLG 344 IG GS+G VY+A + + AVKK+ S E + + ++ + +LKH N +E G Sbjct: 30 IGHGSFGAVYFATNSTTNEIVAVKKMSYSGKQMNEKWQDIIKEVKFLQQLKHPNTIEYKG 89 Query: 345 YCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHE 524 ++ + + E+ +GS D+L K L ++ I A +GLAYLH Sbjct: 90 CYLKDHTAWLVMEYC-LGSASDLLEVHK--------KPLQEVEIAAITHGALQGLAYLHS 140 Query: 525 KVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 +++HRDI++ N+LL E + K+ADF +++S Sbjct: 141 H---NMIHRDIKAGNILLTEPGQVKLADFGSASKS 172
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 68.9 bits (167), Expect = 1e-11 Identities = 49/166 (29%), Positives = 82/166 (49%), Gaps = 17/166 (10%) Frame = +3 Query: 174 IGEGSYGRVYYAI---LDSGKH-----LAVKKLDTSADPEPDNEFLTQLSIVSRL-KHEN 326 +GEG +G+V A +D K +AVK L A + ++ ++++ ++ + KH+N Sbjct: 472 LGEGCFGQVVMAEAIGIDKDKPNKAITVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 531 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQ--------PGPALDWMQRVK 482 + +LG C + V E+A+ G+L + L R+ PG P L + V Sbjct: 532 IINLLGACTQDGPLYVLVEYASKGNLREYLRARR-PPGMDYSFDTCKLPEEQLTFKDLVS 590 Query: 483 IAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A A+G+ YL +HRD+ + NVL+ ED K+ADF L+ Sbjct: 591 CAYQVARGMEYL---ASQKCIHRDLAARNVLVTEDNVMKIADFGLA 633
>FGFR4_RAT (Q498D6) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) Length = 800 Score = 68.9 bits (167), Expect = 1e-11 Identities = 53/186 (28%), Positives = 88/186 (47%), Gaps = 18/186 (9%) Frame = +3 Query: 117 ELSLDELKE-KTDNFGSKALIGEGSYGRVYYAIL--------DSGKHLAVKKLDTSADPE 269 +L LD L E D +GEG +G+V A D +AVK L +A + Sbjct: 451 DLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDK 510 Query: 270 PDNEFLTQLSIVSRL-KHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRK------ 428 + ++++ ++ + +H+N + +LG C + V E+A G+L + L R+ Sbjct: 511 DLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDL 570 Query: 429 --GVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKV 602 P + GP L + V A A+G+ YL + +HRD+ + NVL+ ED K+ Sbjct: 571 SPDGPRSSEGP-LSFPALVSCAYQVARGMQYLESR---KCIHRDLAARNVLVTEDDVMKI 626 Query: 603 ADFNLS 620 ADF L+ Sbjct: 627 ADFGLA 632
>PAK7_MOUSE (Q8C015) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5) Length = 719 Score = 68.9 bits (167), Expect = 1e-11 Identities = 54/165 (32%), Positives = 82/165 (49%), Gaps = 2/165 (1%) Frame = +3 Query: 138 KEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRL 314 +E DNF IGEGS G V A +GK +AVKK+D + F ++ I+ Sbjct: 446 REYLDNF---IKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLF-NEVVIMRDY 501 Query: 315 KHENFVEMLGYCVEGNQRLVAYEFATMGSLHDIL-HGRKGVPGAQPGPALDWMQRVKIAI 491 H+N V+M + G++ V EF G+L DI+ H R ++ Q + + Sbjct: 502 HHDNVVDMYNSYLVGDELWVVMEFLEGGALTDIVTHTR-----------MNEEQIATVCL 550 Query: 492 DAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 K L+YLH + ++HRDI+S ++LL D R K++DF Q Sbjct: 551 SVLKALSYLHNQ---GVIHRDIKSDSILLTSDGRIKLSDFGFCAQ 592
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 68.9 bits (167), Expect = 1e-11 Identities = 46/151 (30%), Positives = 74/151 (49%), Gaps = 1/151 (0%) Frame = +3 Query: 171 LIGEGSYGR-VYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGY 347 ++G+G +G+ + +GK + +K+L D E FLT++ ++ L H N ++ +G Sbjct: 336 VLGKGFFGQAIKVTHKATGKVMVMKEL-IRCDEETQKTFLTEVKVMRSLDHPNVLKFIGV 394 Query: 348 CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 + + + E+ G+L D L P W Q+V+ A A G+AYLH Sbjct: 395 LYKDKKLNLLTEYIEGGTLKDFLRNVDPFP---------WQQKVRFAKGIASGMAYLHSM 445 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 I+HRD+ S N L+ D VADF LS Sbjct: 446 ---CIIHRDLNSHNCLIKLDKTVVVADFGLS 473
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 68.9 bits (167), Expect = 1e-11 Identities = 50/181 (27%), Positives = 95/181 (52%), Gaps = 9/181 (4%) Frame = +3 Query: 105 IEIPELSLDELKEKTDNFGSKALIGE----GSYGRVYYAILDSGKHLAVKKLDTSADPEP 272 +E E S E +E T + S+ IG G++ R+Y I + +AVK + E Sbjct: 66 VETWEASKGEREEWTADL-SQLFIGNKFASGAHSRIYRGIYKQ-RAVAVKMVRIPTHKEE 123 Query: 273 -----DNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVP 437 + +F ++++++SRL H N V+ + C + + E+ + G+L L+ ++ Sbjct: 124 TRAKLEQQFKSEVALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPY- 182 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 +L +++A+D ++G+ YLH + ++HRD++S+N+LL ++ R KVADF Sbjct: 183 ------SLSIETVLRLALDISRGMEYLHSQ---GVIHRDLKSNNLLLNDEMRVKVADFGT 233 Query: 618 S 620 S Sbjct: 234 S 234
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 68.9 bits (167), Expect = 1e-11 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 3/156 (1%) Frame = +3 Query: 177 GEGSYGRVYYA--ILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEML-GY 347 G+G+ G VY A I D+ + +A+K++D A P + + ++ ++ +H+N V L Y Sbjct: 687 GQGASGNVYLAEMIKDNNRKIAIKQMDLDAQPRKEL-IINEILVMKDSQHKNIVNFLDSY 745 Query: 348 CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 + N+ V E+ GSL +I+ L+ Q I + KGL +LH+K Sbjct: 746 LIGDNELWVIMEYMQGGSLTEIIENNDF--------KLNEKQIATICFETLKGLQHLHKK 797 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 I+HRDI+S NVLL K+ DF + D Sbjct: 798 ---HIIHRDIKSDNVLLDAYGNVKITDFGFCAKLTD 830
>MET_PONPY (Q2IBD8) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 68.6 bits (166), Expect = 2e-11 Identities = 49/160 (30%), Positives = 73/160 (45%), Gaps = 5/160 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAIL--DSGK--HLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +IG G +G VY+ L + GK H AVK L+ D ++FLT+ I+ H N + + Sbjct: 1083 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 339 LGYCVEGN-QRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C+ LV + G L + + P + + + AKG+ Y Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--------DLIGFGLQVAKGMKY 1194 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 L K VHRD+ + N +L E + KVADF L+ D Sbjct: 1195 LASK---KFVHRDLAARNCMLDEKFTVKVADFGLARDMYD 1231
>MET_PANTR (Q2QLF1) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 68.6 bits (166), Expect = 2e-11 Identities = 49/160 (30%), Positives = 73/160 (45%), Gaps = 5/160 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAIL--DSGK--HLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +IG G +G VY+ L + GK H AVK L+ D ++FLT+ I+ H N + + Sbjct: 1083 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 339 LGYCVEGN-QRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C+ LV + G L + + P + + + AKG+ Y Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--------DLIGFGLQVAKGMKY 1194 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 L K VHRD+ + N +L E + KVADF L+ D Sbjct: 1195 LASK---KFVHRDLAARNCMLDEKFTVKVADFGLARDMYD 1231
>MET_HUMAN (P08581) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 68.6 bits (166), Expect = 2e-11 Identities = 49/160 (30%), Positives = 73/160 (45%), Gaps = 5/160 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAIL--DSGK--HLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +IG G +G VY+ L + GK H AVK L+ D ++FLT+ I+ H N + + Sbjct: 1083 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 339 LGYCVEGN-QRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C+ LV + G L + + P + + + AKG+ Y Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--------DLIGFGLQVAKGMKY 1194 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 L K VHRD+ + N +L E + KVADF L+ D Sbjct: 1195 LASK---KFVHRDLAARNCMLDEKFTVKVADFGLARDMYD 1231
>ROR1_MOUSE (Q9Z139) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1) Length = 937 Score = 68.6 bits (166), Expect = 2e-11 Identities = 46/164 (28%), Positives = 78/164 (47%), Gaps = 13/164 (7%) Frame = +3 Query: 174 IGEGSYGRVYYAIL-----DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +GE ++G++Y L D + +A+K L +P+ EF + S+++ L H N V + Sbjct: 479 LGECTFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCL 538 Query: 339 LGYCVEGNQRLVAYEFATMGSLHDIL-----HGRKGVPGAQPG---PALDWMQRVKIAID 494 LG + + +E+ G LH+ L H G + G +LD + IAI Sbjct: 539 LGAVTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQ 598 Query: 495 AAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 A G+ YL VH+D+ + N+L+ E K++D LS + Sbjct: 599 IAAGMEYLSSHF---FVHKDLAARNILIGEQLHVKISDLGLSRE 639
>PAK4_MOUSE (Q8BTW9) Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1)| (p21-activated kinase 4) (PAK-4) Length = 593 Score = 68.6 bits (166), Expect = 2e-11 Identities = 55/161 (34%), Positives = 81/161 (50%), Gaps = 2/161 (1%) Frame = +3 Query: 150 DNFGSKALIGEGSYGRVYYA-ILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHEN 326 DNF IGEGS G V A + SGK +AVKK+D + F ++ I+ +HEN Sbjct: 324 DNF---IKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLF-NEVVIMRDYRHEN 379 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDIL-HGRKGVPGAQPGPALDWMQRVKIAIDAAK 503 VEM + G++ V EF G+L DI+ H R ++ Q + + + Sbjct: 380 VVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR-----------MNEEQIAAVCLAVLQ 428 Query: 504 GLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 LA LH + ++HRDI+S ++LL D R K++DF Q Sbjct: 429 ALAVLHAQ---GVIHRDIKSDSILLTHDGRVKLSDFGFCAQ 466
>CDKL2_MOUSE (Q9QUK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 568 Score = 68.6 bits (166), Expect = 2e-11 Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 2/162 (1%) Frame = +3 Query: 141 EKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKK-LDTSADPEPDNEFLTQLSIVSRL 314 EK +N G L+GEGSYG V DSG+ +A+KK L++ D + ++ ++ +L Sbjct: 2 EKYENLG---LVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQL 58 Query: 315 KHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAID 494 +HEN V +L C + + + +EF H IL K P LD+ K Sbjct: 59 RHENLVNLLEVCKKKKRWYLVFEFVD----HTILDDLKLFPN-----GLDYQVVQKYLFQ 109 Query: 495 AAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 G+ + H +I+HRDI+ N+L+ + K+ DF + Sbjct: 110 IINGIGFCHSH---NIIHRDIKPENILVSQSGVVKLCDFGFA 148
>MET_HORSE (Q2QLA9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 68.6 bits (166), Expect = 2e-11 Identities = 48/160 (30%), Positives = 71/160 (44%), Gaps = 5/160 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAIL----DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +IG G +G VY+ L D H AVK L+ D ++FLT+ I+ H N + + Sbjct: 1083 VIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 339 LGYCVEG-NQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C+ LV + G L + + P + + + AKG+ Y Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--------DLIGFGLQVAKGMKY 1194 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 L K VHRD+ + N +L E + KVADF L+ D Sbjct: 1195 LASK---KFVHRDLAARNCMLDEKFTVKVADFGLARDMYD 1231
>MET_CALMO (Q2QLC0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 68.6 bits (166), Expect = 2e-11 Identities = 49/160 (30%), Positives = 73/160 (45%), Gaps = 5/160 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAIL--DSGK--HLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +IG G +G VY+ L + GK H AVK L+ D ++FLT+ I+ H N + + Sbjct: 1083 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 339 LGYCVEGN-QRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C+ LV + G L + + P + + + AKG+ Y Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--------DLIGFGLQVAKGMKY 1194 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 L K VHRD+ + N +L E + KVADF L+ D Sbjct: 1195 LASK---KFVHRDLAARNCMLDEKFTVKVADFGLARDMYD 1231
>MET_CALJA (Q2QLG5) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 68.6 bits (166), Expect = 2e-11 Identities = 49/160 (30%), Positives = 73/160 (45%), Gaps = 5/160 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAIL--DSGK--HLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +IG G +G VY+ L + GK H AVK L+ D ++FLT+ I+ H N + + Sbjct: 1083 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 339 LGYCVEGN-QRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C+ LV + G L + + P + + + AKG+ Y Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--------DLIGFGLQVAKGMKY 1194 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 L K VHRD+ + N +L E + KVADF L+ D Sbjct: 1195 LASK---KFVHRDLAARNCMLDEKFTVKVADFGLARDMYD 1231
>CDKL2_RAT (Q5XIT0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 507 Score = 68.6 bits (166), Expect = 2e-11 Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 2/162 (1%) Frame = +3 Query: 141 EKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKK-LDTSADPEPDNEFLTQLSIVSRL 314 EK +N G L+GEGSYG V DSG+ +A+KK L++ D + ++ ++ +L Sbjct: 2 EKYENLG---LVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQL 58 Query: 315 KHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAID 494 +HEN V +L C + + + +EF H IL K P LD+ K Sbjct: 59 RHENLVNLLEVCKKKKRWYLVFEFVD----HTILDDLKLFPN-----GLDYQVVQKYLFQ 109 Query: 495 AAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 G+ + H +I+HRDI+ N+L+ + K+ DF + Sbjct: 110 IINGIGFCHSH---NIIHRDIKPENILVSQSGVVKLCDFGFA 148
>MET_MICMU (Q2QL89) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 68.6 bits (166), Expect = 2e-11 Identities = 49/160 (30%), Positives = 73/160 (45%), Gaps = 5/160 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAIL--DSGK--HLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +IG G +G VY+ L + GK H AVK L+ D ++FLT+ I+ H N + + Sbjct: 1084 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1143 Query: 339 LGYCVEGN-QRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C+ LV + G L + + P + + + AKG+ Y Sbjct: 1144 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--------DLIGFGLQVAKGMKY 1195 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 L K VHRD+ + N +L E + KVADF L+ D Sbjct: 1196 LASK---KFVHRDLAARNCMLDEKFTVKVADFGLARDMYD 1232
>MET_CANFA (Q75ZY9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 68.6 bits (166), Expect = 2e-11 Identities = 48/160 (30%), Positives = 71/160 (44%), Gaps = 5/160 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAIL----DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +IG G +G VY+ L D H AVK L+ D ++FLT+ I+ H N + + Sbjct: 1084 VIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1143 Query: 339 LGYCVEG-NQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C+ LV + G L + + P + + + AKG+ Y Sbjct: 1144 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--------DLIGFGLQVAKGMKY 1195 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 L K VHRD+ + N +L E + KVADF L+ D Sbjct: 1196 LASK---KFVHRDLAARNCMLDEKFTVKVADFGLARDMYD 1232
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 68.6 bits (166), Expect = 2e-11 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ + +G+G +G V+ + +A+K L Sbjct: 248 PTSKP---QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 304 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V++ Y V + + + E+ + GSL D L G Sbjct: 305 SPEA---FLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVTEYMSKGSLLDFLKG----- 354 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V +A A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 355 --ETGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 409 Query: 618 SNQSPD 635 + D Sbjct: 410 ARLIED 415
>STK3_MOUSE (Q9JI10) Serine/threonine-protein kinase 3 (EC 2.7.11.1)| (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) Length = 497 Score = 68.6 bits (166), Expect = 2e-11 Identities = 53/178 (29%), Positives = 89/178 (50%), Gaps = 2/178 (1%) Frame = +3 Query: 108 EIPELSLDEL-KEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDNE 281 ++ +LS D L K+ + F +GEGSYG V+ AI +SG+ +A+K++ +D + E Sbjct: 10 KLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ---E 66 Query: 282 FLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPAL 461 + ++SI+ + V+ G + + E+ GS+ DI+ R L Sbjct: 67 IIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN--------KTL 118 Query: 462 DWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 + I KGL YLH + +HRDI++ N+LL + AK+ADF ++ Q D Sbjct: 119 TEDEIATILKSTLKGLEYLHFMRK---IHRDIKAGNILLNTEGHAKLADFGVAGQLTD 173
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 68.2 bits (165), Expect = 2e-11 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ + +G+G +G V+ + +A+K L Sbjct: 245 PTSKP---QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 301 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V++ Y V + + + E+ + GSL D L G Sbjct: 302 SPEA---FLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVTEYMSKGSLLDFLKG----- 351 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V +A A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 352 --EMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 406 Query: 618 SNQSPD 635 + D Sbjct: 407 ARLIED 412
>MIPR_LYMST (Q25410) Putative molluscan insulin-related peptide(s) receptor| precursor (EC 2.7.10.1) [Contains: Putative molluscan insulin-related peptide(s) receptor alpha chain; Putative molluscan insulin-related peptide(s) receptor beta chain] Length = 1607 Score = 68.2 bits (165), Expect = 2e-11 Identities = 53/183 (28%), Positives = 85/183 (46%), Gaps = 10/183 (5%) Frame = +3 Query: 102 PIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKH-------LAVKKLDTSA 260 P EI +S DE + D +G+GS+G VY + + +AVK ++ A Sbjct: 1020 PSEILYIS-DEWEVDRDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVNDRA 1078 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRK---G 431 EFL + + + + V++LG G LV E +G L + L G + Sbjct: 1079 SFSDRREFLKEATTMKEFHCHHVVKLLGVVSTGQPALVIMELMALGDLKNYLRGHRPDED 1138 Query: 432 VPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADF 611 PG P LD +Q +A + A G+AYL +K VHRD+ + N ++ E+ K+ DF Sbjct: 1139 HPGVMPPHLLDILQ---MAGEIADGMAYLADK---KFVHRDLAARNCMVSEERTVKIGDF 1192 Query: 612 NLS 620 ++ Sbjct: 1193 GMT 1195
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 68.2 bits (165), Expect = 2e-11 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ + +G+G +G V+ + +A+K L Sbjct: 245 PTSKP---QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 301 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V++ Y V + + + E+ + GSL D L G Sbjct: 302 SPEA---FLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVTEYMSKGSLLDFLKG----- 351 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V +A A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 352 --EMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 406 Query: 618 SNQSPD 635 + D Sbjct: 407 ARLIED 412
>IGF1R_HUMAN (P08069) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 recepto Length = 1367 Score = 68.2 bits (165), Expect = 2e-11 Identities = 45/173 (26%), Positives = 80/173 (46%), Gaps = 9/173 (5%) Frame = +3 Query: 129 DELKEKTDNFGSKALIGEGSYGRVYYAIL------DSGKHLAVKKLDTSADPEPDNEFLT 290 DE + + +G+GS+G VY + + +A+K ++ +A EFL Sbjct: 990 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1049 Query: 291 QLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPAL--- 461 + S++ + V +LG +G LV E T G L L + P + P L Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR--PEMENNPVLAPP 1107 Query: 462 DWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + +++A + A G+AYL+ VHRD+ + N ++ ED+ K+ DF ++ Sbjct: 1108 SLSKMIQMAGEIADGMAYLNAN---KFVHRDLAARNCMVAEDFTVKIGDFGMT 1157
>M4K2_MOUSE (Q61161) Mitogen-activated protein kinase kinase kinase kinase 2| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein) Length = 821 Score = 68.2 bits (165), Expect = 2e-11 Identities = 52/165 (31%), Positives = 80/165 (48%), Gaps = 1/165 (0%) Frame = +3 Query: 135 LKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQ-LSIVSR 311 L++ D F +G G+YG VY A LA K+ DP D L Q ++I+ Sbjct: 9 LQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKI-VKLDPGDDISSLQQEITILRE 67 Query: 312 LKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAI 491 +H N V +G + ++ + EF GSL +I H GP L+ Q + Sbjct: 68 CRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHA--------TGP-LEERQIAYVCR 118 Query: 492 DAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 +A KGL +LH + + +HRDI+ +N+LL K+ADF +S + Sbjct: 119 EALKGLHHLHSQGK---IHRDIKGANLLLTLQGDVKLADFGVSGE 160
>MET_PIG (Q2QLE0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 68.2 bits (165), Expect = 2e-11 Identities = 48/160 (30%), Positives = 71/160 (44%), Gaps = 5/160 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAIL----DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +IG G +G VY+ L D H AVK L+ D ++FLT+ I+ H N + + Sbjct: 1083 VIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 339 LGYCVEG-NQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 LG C+ LV + G L + + P + + + AKG+ Y Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--------DLIGFGLQVAKGMKY 1194 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 L K VHRD+ + N +L E + KVADF L+ D Sbjct: 1195 LASK---KFVHRDLAARNCMLDEKFTVKVADFGLARDVYD 1231
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 68.2 bits (165), Expect = 2e-11 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ + +G+G +G V+ + +A+K L Sbjct: 245 PTSKP---QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 301 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V++ Y V + + + E+ + GSL D L G Sbjct: 302 SPEA---FLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVTEYMSKGSLLDFLKG----- 351 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V +A A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 352 --EMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 406 Query: 618 SNQSPD 635 + D Sbjct: 407 ARLIED 412
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 68.2 bits (165), Expect = 2e-11 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ + +G+G +G V+ + +A+K L Sbjct: 245 PTSKP---QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 301 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V++ Y V + + + E+ + GSL D L G Sbjct: 302 SPEA---FLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVTEYMSKGSLLDFLKG----- 351 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V +A A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 352 --EMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 406 Query: 618 SNQSPD 635 + D Sbjct: 407 ARLIED 412
>TAOK3_MOUSE (Q8BYC6) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 68.2 bits (165), Expect = 2e-11 Identities = 49/155 (31%), Positives = 81/155 (52%), Gaps = 3/155 (1%) Frame = +3 Query: 174 IGEGSYGRVYYAI-LDSGKHLAVKKLDTSADP--EPDNEFLTQLSIVSRLKHENFVEMLG 344 IG GS+G VY+A + + +AVKK+ S E + L ++ + +LKH N +E G Sbjct: 30 IGHGSFGAVYFATNAHTNEVVAVKKMSYSGKQTHEKWQDILKEVKFLQQLKHPNTIEYKG 89 Query: 345 YCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHE 524 ++ + + E+ +GS D+L K L ++ I A +GLAYLH Sbjct: 90 CYLKEHTAWLVMEYC-LGSASDLLEVHK--------KPLQEVEIAAITHGALQGLAYLHF 140 Query: 525 KVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 S++HRDI++ N+LL E + K+ADF ++ + Sbjct: 141 H---SLIHRDIKAGNILLTEPGQVKLADFGSASMA 172
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 68.2 bits (165), Expect = 2e-11 Identities = 52/154 (33%), Positives = 81/154 (52%), Gaps = 2/154 (1%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCV 353 IG+G +G V G +AVK + A + FL + S++++L+H N V++LG V Sbjct: 201 IGKGEFGDVMLGDY-RGNKVAVKCIKNDATAQA---FLAEASVMTQLRHSNLVQLLGVIV 256 Query: 354 EGNQRL-VAYEFATMGSLHDILHGR-KGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 E L + E+ GSL D L R + V G G L +K ++D + + YL Sbjct: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG---GDCL-----LKFSLDVCEAMEYLEGN 308 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 + VHRD+ + NVL+ ED AKV+DF L+ ++ Sbjct: 309 ---NFVHRDLAARNVLVSEDNVAKVSDFGLTKEA 339
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 68.2 bits (165), Expect = 2e-11 Identities = 52/154 (33%), Positives = 81/154 (52%), Gaps = 2/154 (1%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCV 353 IG+G +G V G +AVK + A + FL + S++++L+H N V++LG V Sbjct: 201 IGKGEFGDVMLGDY-RGNKVAVKCIKNDATAQA---FLAEASVMTQLRHSNLVQLLGVIV 256 Query: 354 EGNQRL-VAYEFATMGSLHDILHGR-KGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 E L + E+ GSL D L R + V G G L +K ++D + + YL Sbjct: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG---GDCL-----LKFSLDVCEAMEYLEGN 308 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 + VHRD+ + NVL+ ED AKV+DF L+ ++ Sbjct: 309 ---NFVHRDLAARNVLVSEDNVAKVSDFGLTKEA 339
>INSR_HUMAN (P06213) Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220| antigen) [Contains: Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1382 Score = 68.2 bits (165), Expect = 2e-11 Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 7/156 (4%) Frame = +3 Query: 174 IGEGSYGRVYYAIL------DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVE 335 +G+GS+G VY ++ +AVK ++ SA EFL + S++ + V Sbjct: 1029 LGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVR 1088 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPG-PALDWMQRVKIAIDAAKGLA 512 +LG +G LV E G L L + PG P + +++A + A G+A Sbjct: 1089 LLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMA 1148 Query: 513 YLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 YL+ K VHRD+ + N ++ D+ K+ DF ++ Sbjct: 1149 YLNAK---KFVHRDLAARNCMVAHDFTVKIGDFGMT 1181
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 68.2 bits (165), Expect = 2e-11 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ + +G+G +G V+ + +A+K L Sbjct: 245 PTSKP---QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 301 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V++ Y V + + + E+ + GSL D L G Sbjct: 302 SPEA---FLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVTEYMSKGSLLDFLKG----- 351 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V +A A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 352 --EMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 406 Query: 618 SNQSPD 635 + D Sbjct: 407 ARLIED 412
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 68.2 bits (165), Expect = 2e-11 Identities = 49/163 (30%), Positives = 82/163 (50%), Gaps = 8/163 (4%) Frame = +3 Query: 171 LIGEGSYGR-VYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGY 347 ++G+G +G+ + ++G+ + +K+L D E FL ++ ++ L+H N ++ +G Sbjct: 344 VLGKGCFGQAIKVTHRETGEVMVMKEL-IRFDEETQRTFLKEVKVMRCLEHPNVLKFIGV 402 Query: 348 CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 + + E+ G+L I+ K + P W QRV A D A G+AYLH Sbjct: 403 LYKDKRLNFITEYIKGGTLRGII---KNMDSQYP-----WSQRVSFAKDIASGMAYLHSM 454 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLS-------NQSPD 635 +I+HRD+ S N L+ E+ VADF L+ NQS D Sbjct: 455 ---NIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKNQSED 494
>IGF1R_BOVIN (Q05688) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (F Length = 640 Score = 68.2 bits (165), Expect = 2e-11 Identities = 45/173 (26%), Positives = 80/173 (46%), Gaps = 9/173 (5%) Frame = +3 Query: 129 DELKEKTDNFGSKALIGEGSYGRVYYAIL------DSGKHLAVKKLDTSADPEPDNEFLT 290 DE + + +G+GS+G VY + + +A+K ++ +A EFL Sbjct: 263 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 322 Query: 291 QLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPAL--- 461 + S++ + V +LG +G LV E T G L L + P + P L Sbjct: 323 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR--PEMENNPVLAPP 380 Query: 462 DWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + +++A + A G+AYL+ VHRD+ + N ++ ED+ K+ DF ++ Sbjct: 381 SLSKMIQMAGEIADGMAYLNAN---KFVHRDLAARNCMVAEDFTVKIGDFGMT 430
>FGFR4_HUMAN (P22455) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) (CD334 antigen) Length = 802 Score = 68.2 bits (165), Expect = 2e-11 Identities = 53/186 (28%), Positives = 87/186 (46%), Gaps = 18/186 (9%) Frame = +3 Query: 117 ELSLDELKE-KTDNFGSKALIGEGSYGRVYYAIL--------DSGKHLAVKKLDTSADPE 269 +L LD L E D +GEG +G+V A D +AVK L +A + Sbjct: 453 DLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDK 512 Query: 270 PDNEFLTQLSIVSRL-KHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGV---- 434 + ++++ ++ + +H+N + +LG C + V E A G+L + L R+ Sbjct: 513 DLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDL 572 Query: 435 ----PGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKV 602 P + GP L + V A A+G+ YL + +HRD+ + NVL+ ED K+ Sbjct: 573 SPDGPRSSEGP-LSFPVLVSCAYQVARGMQYLESR---KCIHRDLAARNVLVTEDNVMKI 628 Query: 603 ADFNLS 620 ADF L+ Sbjct: 629 ADFGLA 634
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 68.2 bits (165), Expect = 2e-11 Identities = 45/161 (27%), Positives = 78/161 (48%), Gaps = 7/161 (4%) Frame = +3 Query: 174 IGEGSYGRVYYAILD-----SGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +GEG +G+V D +G+ +AVK L P+ + + ++ I+ L HE+ ++ Sbjct: 903 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKY 962 Query: 339 LGYCVEGNQRLV--AYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLA 512 G C + ++ + E+ +GSL D L P ++ Q + A +G+A Sbjct: 963 KGCCEDQGEKSLQLVMEYVPLGSLRDYL----------PRHSIGLAQLLLFAQQICEGMA 1012 Query: 513 YLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 YLH + +HRD+ + NVLL D K+ DF L+ P+ Sbjct: 1013 YLHAQ---HYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPE 1050
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 68.2 bits (165), Expect = 2e-11 Identities = 47/161 (29%), Positives = 77/161 (47%), Gaps = 7/161 (4%) Frame = +3 Query: 174 IGEGSYGRVYYAILD-----SGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +GEG +G+V D +G+ +AVK L P+ + + ++ I+ L HE+ V+ Sbjct: 896 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKY 955 Query: 339 LGYCVEGNQRLV--AYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLA 512 G C + ++ V E+ +GSL D L P + Q + A +G+A Sbjct: 956 KGCCEDQGEKSVQLVMEYVPLGSLRDYL----------PRHCVGLAQLLLFAQQICEGMA 1005 Query: 513 YLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 YLH + +HRD+ + NVLL D K+ DF L+ P+ Sbjct: 1006 YLHAQ---HYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPE 1043
>ROR1_HUMAN (Q01973) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) Length = 937 Score = 67.8 bits (164), Expect = 3e-11 Identities = 46/164 (28%), Positives = 78/164 (47%), Gaps = 13/164 (7%) Frame = +3 Query: 174 IGEGSYGRVYYAIL-----DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +GE ++G++Y L D + +A+K L +P+ EF + S+++ L H N V + Sbjct: 479 LGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWMEFQQEASLMAELHHPNIVCL 538 Query: 339 LGYCVEGNQRLVAYEFATMGSLHDIL-----HGRKGVPGAQPG---PALDWMQRVKIAID 494 LG + + +E+ G LH+ L H G + G +LD + IAI Sbjct: 539 LGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQ 598 Query: 495 AAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 A G+ YL VH+D+ + N+L+ E K++D LS + Sbjct: 599 IAAGMEYLSSHF---FVHKDLAARNILIGEQLHVKISDLGLSRE 639
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 67.8 bits (164), Expect = 3e-11 Identities = 40/149 (26%), Positives = 75/149 (50%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCV 353 IG G +G V+ + +A+K + A E D F+ + ++ +L H V++ G C+ Sbjct: 374 IGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEED--FIEEAEVMMKLSHPKLVQLYGVCL 431 Query: 354 EGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQ 533 E + +EF G L D L ++G+ A+ + + +D +G+AYL + Sbjct: 432 EQAPICLVFEFMEHGCLSDYLRSQRGLFAAE--------TLLGMCLDVCEGMAYLE---K 480 Query: 534 PSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 ++HRD+ + N L+ E+ KV+DF ++ Sbjct: 481 ACVIHRDLAARNCLVGENQVIKVSDFGMT 509
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 67.8 bits (164), Expect = 3e-11 Identities = 48/165 (29%), Positives = 85/165 (51%), Gaps = 10/165 (6%) Frame = +3 Query: 171 LIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDNEFLT-------QLSIVSRLKHEN 326 +IG+GS+G VY + + +G+ +AVK+++ + L+ ++S + L H N Sbjct: 1180 MIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLN 1239 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDIL--HGRKGVPGAQPGPALDWMQRVKIAIDAA 500 V+ LG+ + N + E+ GS+ ++ +GR P + + Sbjct: 1240 IVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIK-----------HLTTQVL 1288 Query: 501 KGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 KGLAYLH K I+HRD+++ N+LL +D K++DF +S +S D Sbjct: 1289 KGLAYLHSK---GILHRDMKADNLLLDQDGICKISDFGISRKSKD 1330
>TAOK3_RAT (Q53UA7) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory kinase) (Axotomy-related gene 357 protein) Length = 898 Score = 67.8 bits (164), Expect = 3e-11 Identities = 55/177 (31%), Positives = 89/177 (50%), Gaps = 3/177 (1%) Frame = +3 Query: 108 EIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADP--EPDN 278 EI EL E E+ F IG GS+G VY+A + + +A+KK+ S E Sbjct: 10 EIAELFFKEDPEEL--FIDLHEIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQ 67 Query: 279 EFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPA 458 + L ++ + +LKH N +E G ++ + + E+ +GS D+L K Sbjct: 68 DILKEVRFLQQLKHPNTIEYKGCYLKEHTAWLVMEYC-LGSASDLLEVHK--------KP 118 Query: 459 LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 L ++ I A +GLAYLH S++HRDI++ N+LL E + K+ADF ++ + Sbjct: 119 LQEVEIAAITHGALQGLAYLHFH---SLIHRDIKAGNILLTEPGQVKLADFGSASMA 172
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 67.8 bits (164), Expect = 3e-11 Identities = 52/154 (33%), Positives = 81/154 (52%), Gaps = 2/154 (1%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCV 353 IG+G +G V G +AVK + A + FL + S++++L+H N V++LG V Sbjct: 201 IGKGEFGDVMLGDY-RGNKVAVKCIKNDATAQA---FLAEASVMTQLRHSNLVQLLGVIV 256 Query: 354 EGNQRL-VAYEFATMGSLHDILHGR-KGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 E L + E+ GSL D L R + V G G L +K ++D + + YL Sbjct: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG---GDCL-----LKFSLDVLEAMEYLEGN 308 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 + VHRD+ + NVL+ ED AKV+DF L+ ++ Sbjct: 309 ---NFVHRDLAARNVLVSEDNVAKVSDFGLTKEA 339
>EGFR_DROME (P04412) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Egfr) (Gurken receptor) (Protein torpedo) (Drosophila relative of ERBB) Length = 1426 Score = 67.8 bits (164), Expect = 3e-11 Identities = 45/155 (29%), Positives = 82/155 (52%), Gaps = 5/155 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAI-LDSGKHL----AVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVE 335 ++G G++GRVY + + G+++ A+K+L S E EFL + I++ +H N ++ Sbjct: 943 VLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLK 1002 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 +L C+ L+ + +G L D + + G++ L+W ++ AKG++Y Sbjct: 1003 LLAVCMSSQMMLIT-QLMPLGCLLDYVRNNRDKIGSK--ALLNWSTQI------AKGMSY 1053 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 L EK +VHRD+ + NVL+ K+ DF L+ Sbjct: 1054 LEEK---RLVHRDLAARNVLVQTPSLVKITDFGLA 1085
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 67.8 bits (164), Expect = 3e-11 Identities = 46/156 (29%), Positives = 79/156 (50%), Gaps = 1/156 (0%) Frame = +3 Query: 171 LIGEGSYGR-VYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGY 347 ++G+G +G+ + ++G+ + +K+L D E FL ++ ++ L+H N ++ +G Sbjct: 344 VLGKGCFGQAIKVTHRETGEVMVMKEL-IRFDEETQRTFLKEVKVMRCLEHPNVLKFIGV 402 Query: 348 CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 + + E+ G+L I+ K + P W QRV A D A G+AYLH Sbjct: 403 LYKDKRLNFITEYIKGGTLRGII---KSMDSQYP-----WSQRVSFAKDIASGMAYLHSM 454 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 +I+HRD+ S N L+ E+ VADF L+ D Sbjct: 455 ---NIIHRDLNSHNCLVRENKNVVVADFGLARLMVD 487
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 67.8 bits (164), Expect = 3e-11 Identities = 52/185 (28%), Positives = 88/185 (47%), Gaps = 1/185 (0%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ + +G+G +G V+ + +A+K L Sbjct: 242 PTSKP---QTQGLAKDAWEIPRESLRLEVKLGQGYFGEVWMGTWNGTTRVAIKTLKPGTM 298 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPG 440 PE FL + ++ +L+HE V++ E + E+ + GSL D L G Sbjct: 299 SPEA---FLQEAQVMKKLRHEKLVQLYAMVSE-EPIYIVIEYMSKGSLLDFLKG------ 348 Query: 441 AQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + G L Q V++A A G+AY+ + VHRD+R++N+L+ E+ KVADF L+ Sbjct: 349 -EMGKYLRLPQLVEMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLA 404 Query: 621 NQSPD 635 D Sbjct: 405 RLIED 409
>LIMK2_MOUSE (O54785) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 67.8 bits (164), Expect = 3e-11 Identities = 45/151 (29%), Positives = 74/151 (49%), Gaps = 1/151 (0%) Frame = +3 Query: 171 LIGEGSYGR-VYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGY 347 ++G+G +G+ + +GK + +K+L D E FLT++ ++ L H N ++ +G Sbjct: 336 VLGKGFFGQAIKVTHKATGKVMVMKEL-IRCDEETQKTFLTEVKVMRSLDHPNVLKFIGV 394 Query: 348 CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 + + + E+ G+L D L P W Q+V+ A + G+AYLH Sbjct: 395 LYKDKKLNLLTEYIEGGTLKDFLRSVDPFP---------WQQKVRFAKGISSGMAYLHSM 445 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 I+HRD+ S N L+ D VADF LS Sbjct: 446 ---CIIHRDLNSHNCLIKLDKTVVVADFGLS 473
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 67.8 bits (164), Expect = 3e-11 Identities = 41/149 (27%), Positives = 75/149 (50%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCV 353 IG G +G V+ + +A+K + A E D F+ + ++ +L H V++ G C+ Sbjct: 369 IGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEED--FIEEAEVMMKLSHPKLVQLYGVCL 426 Query: 354 EGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQ 533 E + +EF G L D L ++G+ A+ + + +D +G+AYL E Sbjct: 427 EQAPICLVFEFMEHGCLSDYLRTQRGLFAAE--------TLLGMCLDVCEGMAYLEE--- 475 Query: 534 PSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 ++HRD+ + N L+ E+ KV+DF ++ Sbjct: 476 ACVIHRDLAARNCLVGENQVIKVSDFGMT 504
>TAO1A_XENLA (Q6NU21) Serine/threonine-protein kinase TAO1-A (EC 2.7.11.1)| (Thousand and one amino acid protein 1-A) Length = 1001 Score = 67.4 bits (163), Expect = 3e-11 Identities = 52/171 (30%), Positives = 85/171 (49%), Gaps = 3/171 (1%) Frame = +3 Query: 108 EIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHL-AVKKLDTSADPEPDN-- 278 +I EL + EK F IG GS+G VY+A S + + A+KK+ S + Sbjct: 14 DIAELFFRDDPEKL--FSDLREIGHGSFGAVYFAHDASTREVVAIKKMSYSGKQSNEKWQ 71 Query: 279 EFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPA 458 + + ++ + R+KH N +E G + + + E+ +GS D+L K Sbjct: 72 DIVKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYC-LGSASDLLEVHK--------KP 122 Query: 459 LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADF 611 L ++ I A +GLAYLH +++HRDI++ N+LL E + K+ADF Sbjct: 123 LQEIEIAAITHGALQGLAYLHSH---NLIHRDIKAGNILLTEPGQVKLADF 170
>M4K3_HUMAN (Q8IVH8) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) Length = 894 Score = 67.4 bits (163), Expect = 3e-11 Identities = 50/155 (32%), Positives = 80/155 (51%), Gaps = 4/155 (2%) Frame = +3 Query: 174 IGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDNEFLT---QLSIVSRLKHENFVEML 341 IG G+YG VY A +++G+ A+K + EP +F ++ ++ KH N V Sbjct: 22 IGSGTYGDVYKARNVNTGELAAIKVIKL----EPGEDFAVVQQEIIMMKDCKHPNIVAYF 77 Query: 342 GYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 G + ++ + EF GSL DI H GP L +Q ++ + +GL YLH Sbjct: 78 GSYLRRDKLWICMEFCGGGSLQDIYH--------VTGP-LSELQIAYVSRETLQGLYYLH 128 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 K + +HRDI+ +N+LL ++ K+ADF +S Q Sbjct: 129 SKGK---MHRDIKGANILLTDNGHVKLADFGVSAQ 160
>M4K3_MOUSE (Q99JP0) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) (Fragments) Length = 681 Score = 67.4 bits (163), Expect = 3e-11 Identities = 50/155 (32%), Positives = 80/155 (51%), Gaps = 4/155 (2%) Frame = +3 Query: 174 IGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDNEFLT---QLSIVSRLKHENFVEML 341 IG G+YG VY A +++G+ A+K + EP +F ++ ++ KH N V Sbjct: 22 IGSGTYGDVYKARNVNTGELAAIKVIKL----EPGEDFAVVQQEIIMMKDCKHPNIVAYF 77 Query: 342 GYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 G + ++ + EF GSL DI H GP L +Q ++ + +GL YLH Sbjct: 78 GSYLRRDKLWICMEFCGGGSLQDIYH--------VTGP-LSELQIAYVSRETLQGLYYLH 128 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 K + +HRDI+ +N+LL ++ K+ADF +S Q Sbjct: 129 SKGK---MHRDIKGANILLTDNGHVKLADFGVSAQ 160
>FGFR4_MOUSE (Q03142) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) Length = 799 Score = 67.4 bits (163), Expect = 3e-11 Identities = 53/186 (28%), Positives = 87/186 (46%), Gaps = 18/186 (9%) Frame = +3 Query: 117 ELSLDELKE-KTDNFGSKALIGEGSYGRVYYAIL--------DSGKHLAVKKLDTSADPE 269 +L LD L E D +GEG +G+V A D +AVK L +A + Sbjct: 450 DLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDK 509 Query: 270 PDNEFLTQLSIVSRL-KHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGV---- 434 + ++++ ++ + +H+N + +LG C + V E A G+L + L R+ Sbjct: 510 DLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDL 569 Query: 435 ----PGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKV 602 P + GP L + V A A+G+ YL + +HRD+ + NVL+ ED K+ Sbjct: 570 SPDGPRSSEGP-LSFPALVSCAYQVARGMQYLESR---KCIHRDLAARNVLVTEDDVMKI 625 Query: 603 ADFNLS 620 ADF L+ Sbjct: 626 ADFGLA 631
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 67.4 bits (163), Expect = 3e-11 Identities = 53/186 (28%), Positives = 89/186 (47%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ + +G+G +G V+ + +A+K L Sbjct: 245 PTSKP---QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 301 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V + Y V + + + E+ + GSL D L G Sbjct: 302 SPEA---FLQEAQVMKKLRHEKLVRL--YAVVSEEPIYIVTEYMSKGSLLDFLKG----- 351 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V +A A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 352 --EMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 406 Query: 618 SNQSPD 635 + D Sbjct: 407 ARLIED 412
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 67.4 bits (163), Expect = 3e-11 Identities = 45/151 (29%), Positives = 78/151 (51%), Gaps = 1/151 (0%) Frame = +3 Query: 171 LIGEGSYGR-VYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGY 347 ++G+G +G+ + ++G+ + +K+L D E FL ++ ++ L+H N ++ +G Sbjct: 344 VLGKGCFGQAIKVTHRETGEVMVMKEL-IRFDEETQRTFLKEVKVMRCLEHPNVLKFIGV 402 Query: 348 CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 + + E+ G+L I+ K + P W QRV A D A G+AYLH Sbjct: 403 LYKDKRLNFITEYIKGGTLRGII---KSMDSQYP-----WSQRVSFAKDIASGMAYLHSM 454 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 +I+HRD+ S N L+ E+ VADF L+ Sbjct: 455 ---NIIHRDLNSHNCLVRENRNVVVADFGLA 482
>M4K3_RAT (Q924I2) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) (Fragment) Length = 862 Score = 67.4 bits (163), Expect = 3e-11 Identities = 50/155 (32%), Positives = 80/155 (51%), Gaps = 4/155 (2%) Frame = +3 Query: 174 IGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDNEFLT---QLSIVSRLKHENFVEML 341 IG G+YG VY A +++G+ A+K + EP +F ++ ++ KH N V Sbjct: 11 IGSGTYGDVYKARNVNTGELAAIKVIKL----EPGEDFAVVQQEIIMMKDCKHANIVAYF 66 Query: 342 GYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 G + ++ + EF GSL DI H GP L +Q ++ + +GL YLH Sbjct: 67 GSYLRRDKLWICMEFCGGGSLQDIYH--------VTGP-LSELQIAYVSRETLQGLYYLH 117 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 K + +HRDI+ +N+LL ++ K+ADF +S Q Sbjct: 118 SKGK---MHRDIKGANILLTDNGHVKLADFGVSAQ 149
>MUSK_CHICK (Q8AXY6) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 947 Score = 67.4 bits (163), Expect = 3e-11 Identities = 50/168 (29%), Positives = 79/168 (47%), Gaps = 19/168 (11%) Frame = +3 Query: 174 IGEGSYGRVYYAIL------DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVE 335 IGEG++GRV+ A + +AVK L A + +F + ++++ + N V+ Sbjct: 661 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVK 720 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDILHGRKG------VPGAQPGP-------ALDWMQR 476 +LG C G + +E+ G L++ L R V G AL + Sbjct: 721 LLGVCAVGKPMCLLFEYMAYGDLNEYLRDRSPRNLCSLVQGGLEARACLLNPLALCCTSQ 780 Query: 477 VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + IA A G+AYL E+ VHRD+ + N L+ E+ K+ADF LS Sbjct: 781 LCIAKQVAAGMAYLSER---KFVHRDLATRNCLVGENMVVKIADFGLS 825
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 67.4 bits (163), Expect = 3e-11 Identities = 47/170 (27%), Positives = 83/170 (48%), Gaps = 14/170 (8%) Frame = +3 Query: 168 ALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRL-KHENFVEMLG 344 A +GEG++GRV A +++ +AVK + + + ++ ++ + +H N + +LG Sbjct: 420 ATLGEGAFGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLG 478 Query: 345 YCVEGNQRLVAYEFATMGSLHDILHGRKGV-----------PGAQPGPALDWMQRVKIAI 491 C + V E+A G+L D L+ + P + P + +K A Sbjct: 479 CCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAH 538 Query: 492 DAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSN--QSPD 635 A+G+ YL + +HRD+ + NVL+ +DY K+ADF L+ QS D Sbjct: 539 QIARGMDYLASR---RCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTD 585
>DDR2_HUMAN (Q16832) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 855 Score = 67.0 bits (162), Expect = 4e-11 Identities = 52/205 (25%), Positives = 91/205 (44%), Gaps = 19/205 (9%) Frame = +3 Query: 63 GFDTKSDPTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKH---- 230 G +T S P + +++++E K F K +GEG +G V+ ++ + Sbjct: 534 GGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEK--LGEGQFGEVHLCEVEGMEKFKDK 591 Query: 231 -------------LAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL 371 +AVK L A+ N+FL ++ I+SRLK N + +L C+ + Sbjct: 592 DFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLSVCITDDPLC 651 Query: 372 VAYEFATMGSLHDILHGRKGVPGAQPGP--ALDWMQRVKIAIDAAKGLAYLHEKVQPSIV 545 + E+ G L+ L R P + + + +A A G+ YL + V Sbjct: 652 MITEYMENGDLNQFL-SRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSL---NFV 707 Query: 546 HRDIRSSNVLLFEDYRAKVADFNLS 620 HRD+ + N L+ ++Y K+ADF +S Sbjct: 708 HRDLATRNCLVGKNYTIKIADFGMS 732
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 67.0 bits (162), Expect = 4e-11 Identities = 52/182 (28%), Positives = 84/182 (46%), Gaps = 3/182 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDS-GKHLAVKKLDTSA 260 P + P I + D+ + + + K +G G YG VY + +AVK L Sbjct: 104 PKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL--KE 161 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILH--GRKGV 434 D EFL + +++ +KH N V++LG C + EF T G+L D L R+ V Sbjct: 162 DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEV 221 Query: 435 PGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFN 614 + + +A + + YL +K + +HRD+ + N L+ E++ KVADF Sbjct: 222 SA---------VVLLYMATQISSAMEYLEKK---NFIHRDLAARNCLVGENHLVKVADFG 269 Query: 615 LS 620 LS Sbjct: 270 LS 271
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 67.0 bits (162), Expect = 4e-11 Identities = 51/177 (28%), Positives = 83/177 (46%), Gaps = 2/177 (1%) Frame = +3 Query: 111 IPELSL--DELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEF 284 IP++ L DE + F + +GEG +G V+ + +AVK + SAD + + Sbjct: 217 IPQIPLVQDEWERPRSEFVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIK-SADMKLA-DL 274 Query: 285 LTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALD 464 ++ + L+HE + + C G + E G+L L G+ G AL Sbjct: 275 TKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYL-------GSSEGKALS 327 Query: 465 WMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 + A A+G++YL E+ +VHRD+ + NVL+ +D KVADF L+ D Sbjct: 328 LPHLLGFACQVAEGMSYLEER---RVVHRDLAARNVLVGDDLTCKVADFGLARLLKD 381
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 67.0 bits (162), Expect = 4e-11 Identities = 52/182 (28%), Positives = 84/182 (46%), Gaps = 3/182 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDS-GKHLAVKKLDTSA 260 P + P I + D+ + + + K +G G YG VY + +AVK L Sbjct: 218 PKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL--KE 275 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILH--GRKGV 434 D EFL + +++ +KH N V++LG C + EF T G+L D L R+ V Sbjct: 276 DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEV 335 Query: 435 PGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFN 614 + + +A + + YL +K + +HRD+ + N L+ E++ KVADF Sbjct: 336 SA---------VVLLYMATQISSAMEYLEKK---NFIHRDLAARNCLVGENHLVKVADFG 383 Query: 615 LS 620 LS Sbjct: 384 LS 385
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 67.0 bits (162), Expect = 4e-11 Identities = 47/153 (30%), Positives = 79/153 (51%), Gaps = 4/153 (2%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGK---HLAVKKLDTSAD-PEPDNEFLTQLSIVSRLKHENFVEML 341 IG GS+G VY GK +AVK L+ +A P+ F ++ ++ + +H N + + Sbjct: 503 IGSGSFGTVY-----KGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFM 557 Query: 342 GYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 GY + +V ++ SL+ LH + + ++ + IA A+G+ YLH Sbjct: 558 GYSTKPQLAIVT-QWCEGSSLYHHLHIIE--------TKFEMIKLIDIARQTAQGMDYLH 608 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 K SI+HRD++S+N+ L ED K+ DF L+ Sbjct: 609 AK---SIIHRDLKSNNIFLHEDLTVKIGDFGLA 638
>LTK_HUMAN (P29376) Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1)| (Protein tyrosine kinase 1) Length = 864 Score = 67.0 bits (162), Expect = 4e-11 Identities = 47/159 (29%), Positives = 77/159 (48%), Gaps = 10/159 (6%) Frame = +3 Query: 174 IGEGSYGRVYYAIL------DSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVE 335 +G G++G VY ++ S +A+K L P+ + +FL + I+S+ +H+N V Sbjct: 516 LGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVR 575 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDIL-HGRKGVPGAQPGPALDWMQRVKIAIDAAKGLA 512 +G + RL+ E + G + L H R + QP P L +++A D A+G Sbjct: 576 CVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL--GQPSP-LVMRDLLQLAQDIAQGCH 632 Query: 513 YLHEKVQPSIVHRDIRSSNVLLF---EDYRAKVADFNLS 620 YL E +HRDI + N LL AK+ DF ++ Sbjct: 633 YLEEN---HFIHRDIAARNCLLSCAGPSRVAKIGDFGMA 668
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 67.0 bits (162), Expect = 4e-11 Identities = 52/186 (27%), Positives = 90/186 (48%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ + +G+G +G V+ + +A+K L Sbjct: 245 PTSKP---QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 301 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+H+ V++ Y V + + + E+ + GSL D L G Sbjct: 302 SPEA---FLQEAQVMKKLRHKKLVQL--YAVVSEEPIYIVIEYMSKGSLLDFLKG----- 351 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V +A A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 352 --EMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 406 Query: 618 SNQSPD 635 + D Sbjct: 407 ARLIED 412
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 67.0 bits (162), Expect = 4e-11 Identities = 47/153 (30%), Positives = 79/153 (51%), Gaps = 4/153 (2%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGK---HLAVKKLDTSAD-PEPDNEFLTQLSIVSRLKHENFVEML 341 IG GS+G VY GK +AVK L+ +A P+ F ++ ++ + +H N + + Sbjct: 503 IGSGSFGTVY-----KGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFM 557 Query: 342 GYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 GY + +V ++ SL+ LH + + ++ + IA A+G+ YLH Sbjct: 558 GYSTKPQLAIVT-QWCEGSSLYHHLHIIE--------TKFEMIKLIDIARQTAQGMDYLH 608 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 K SI+HRD++S+N+ L ED K+ DF L+ Sbjct: 609 AK---SIIHRDLKSNNIFLHEDLTVKIGDFGLA 638
>M4K4_HUMAN (O95819) Mitogen-activated protein kinase kinase kinase kinase 4| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase) Length = 1239 Score = 67.0 bits (162), Expect = 4e-11 Identities = 50/184 (27%), Positives = 90/184 (48%), Gaps = 8/184 (4%) Frame = +3 Query: 99 PPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPD 275 P + ++ L L++ F ++G G+YG+VY + +G+ A+K +D + D E Sbjct: 6 PAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-- 63 Query: 276 NEFLTQLSIVSRLKHE-NFVEMLGYCVE------GNQRLVAYEFATMGSLHDILHGRKGV 434 E +++++ + H N G ++ +Q + EF GS+ D++ KG Sbjct: 64 EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGN 123 Query: 435 PGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFN 614 + DW+ I+ + +GLA+LH ++HRDI+ NVLL E+ K+ DF Sbjct: 124 TLKE-----DWI--AYISREILRGLAHLHIH---HVIHRDIKGQNVLLTENAEVKLVDFG 173 Query: 615 LSNQ 626 +S Q Sbjct: 174 VSAQ 177
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 67.0 bits (162), Expect = 4e-11 Identities = 47/153 (30%), Positives = 79/153 (51%), Gaps = 4/153 (2%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGK---HLAVKKLDTSAD-PEPDNEFLTQLSIVSRLKHENFVEML 341 IG GS+G VY GK +AVK L+ +A P+ F ++ ++ + +H N + + Sbjct: 89 IGSGSFGTVY-----KGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFM 143 Query: 342 GYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 GY + +V ++ SL+ LH + + ++ + IA A+G+ YLH Sbjct: 144 GYSTKPQLAIVT-QWCEGSSLYHHLHIIE--------TKFEMIKLIDIARQTAQGMDYLH 194 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 K SI+HRD++S+N+ L ED K+ DF L+ Sbjct: 195 AK---SIIHRDLKSNNIFLHEDLTVKIGDFGLA 224
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 67.0 bits (162), Expect = 4e-11 Identities = 47/153 (30%), Positives = 79/153 (51%), Gaps = 4/153 (2%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGK---HLAVKKLDTSAD-PEPDNEFLTQLSIVSRLKHENFVEML 341 IG GS+G VY GK +AVK L+ +A P+ F ++ ++ + +H N + + Sbjct: 73 IGSGSFGTVY-----KGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFM 127 Query: 342 GYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 GY + +V ++ SL+ LH + + ++ + IA A+G+ YLH Sbjct: 128 GYSTKPQLAIVT-QWCEGSSLYHHLHIIE--------TKFEMIKLIDIARQTAQGMDYLH 178 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 K SI+HRD++S+N+ L ED K+ DF L+ Sbjct: 179 AK---SIIHRDLKSNNIFLHEDLTVKIGDFGLA 208
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 67.0 bits (162), Expect = 4e-11 Identities = 47/153 (30%), Positives = 79/153 (51%), Gaps = 4/153 (2%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGK---HLAVKKLDTSAD-PEPDNEFLTQLSIVSRLKHENFVEML 341 IG GS+G VY GK +AVK L+ +A P+ F ++ ++ + +H N + + Sbjct: 463 IGSGSFGTVY-----KGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFM 517 Query: 342 GYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 GY + +V ++ SL+ LH + + ++ + IA A+G+ YLH Sbjct: 518 GYSTKPQLAIVT-QWCEGSSLYHHLHIIE--------TKFEMIKLIDIARQTAQGMDYLH 568 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 K SI+HRD++S+N+ L ED K+ DF L+ Sbjct: 569 AK---SIIHRDLKSNNIFLHEDLTVKIGDFGLA 598
>PAK4_HUMAN (O96013) Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1)| (p21-activated kinase 4) (PAK-4) Length = 591 Score = 67.0 bits (162), Expect = 4e-11 Identities = 54/161 (33%), Positives = 81/161 (50%), Gaps = 2/161 (1%) Frame = +3 Query: 150 DNFGSKALIGEGSYGRVYYA-ILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHEN 326 DNF IGEGS G V A + SGK +AVKK+D + F ++ I+ +HEN Sbjct: 322 DNF---IKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLF-NEVVIMRDYQHEN 377 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDIL-HGRKGVPGAQPGPALDWMQRVKIAIDAAK 503 VEM + G++ V EF G+L DI+ H R ++ Q + + + Sbjct: 378 VVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR-----------MNEEQIAAVCLAVLQ 426 Query: 504 GLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 L+ LH + ++HRDI+S ++LL D R K++DF Q Sbjct: 427 ALSVLHAQ---GVIHRDIKSDSILLTHDGRVKLSDFGFCAQ 464
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 67.0 bits (162), Expect = 4e-11 Identities = 52/186 (27%), Positives = 89/186 (47%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ + +G+G +G V+ + +A+K L Sbjct: 253 PTSKP---QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 309 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V++ Y V + + + E+ GSL D L G Sbjct: 310 SPEA---FLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVTEYMNKGSLLDFLKG----- 359 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V ++ A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 360 --ETGKYLRLPQLVDMSAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGL 414 Query: 618 SNQSPD 635 + D Sbjct: 415 ARLIED 420
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 67.0 bits (162), Expect = 4e-11 Identities = 47/153 (30%), Positives = 79/153 (51%), Gaps = 4/153 (2%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGK---HLAVKKLDTSAD-PEPDNEFLTQLSIVSRLKHENFVEML 341 IG GS+G VY GK +AVK L+ +A P+ F ++ ++ + +H N + + Sbjct: 25 IGSGSFGTVY-----KGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFM 79 Query: 342 GYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 GY + +V ++ SL+ LH + + ++ + IA A+G+ YLH Sbjct: 80 GYSTKPQLAIVT-QWCEGSSLYHHLHIIE--------TKFEMIKLIDIARQTAQGMDYLH 130 Query: 522 EKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 K SI+HRD++S+N+ L ED K+ DF L+ Sbjct: 131 AK---SIIHRDLKSNNIFLHEDLTVKIGDFGLA 160
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 66.6 bits (161), Expect = 6e-11 Identities = 46/155 (29%), Positives = 81/155 (52%), Gaps = 5/155 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAI-LDSGKHL----AVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVE 335 ++G G++G VY I + G+ + A+K L+ + P+ + EF+ + I++ + H + V Sbjct: 723 VLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVR 782 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 +LG C+ +LV + G L + +H K G+Q L+W + AKG+ Y Sbjct: 783 LLGVCLSPTIQLVT-QLMPHGCLLEYVHEHKDNIGSQ--LLLNW------CVQIAKGMMY 833 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 L E+ +VHRD+ + NVL+ K+ DF L+ Sbjct: 834 LEER---RLVHRDLAARNVLVKSPNHVKITDFGLA 865
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 66.6 bits (161), Expect = 6e-11 Identities = 50/158 (31%), Positives = 78/158 (49%), Gaps = 5/158 (3%) Frame = +3 Query: 162 SKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEML 341 S+ +G GS G V A + + +AVK D + N +++ +S + HEN + ++ Sbjct: 13 SEKFLGAGSGGAVRKATFQN-QEIAVKIFDFLEETIKKNAE-REITHLSEIDHENVIRVI 70 Query: 342 GYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDW----MQRVKIAIDAAKGL 509 G G + + E+ GSLH+ L+G W Q V+ A+ AK L Sbjct: 71 GRASNGKKDYLLMEYLEEGSLHNYLYGDD-----------KWEYTVEQAVRWALQCAKAL 119 Query: 510 AYLHEKVQPSIVHRDIRSSNVLLFEDYR-AKVADFNLS 620 AYLH +P IVHRDI+ N+LL+ + K+ DF L+ Sbjct: 120 AYLHSLDRP-IVHRDIKPQNMLLYNQHEDLKICDFGLA 156
>M4K4_MOUSE (P97820) Mitogen-activated protein kinase kinase kinase kinase 4| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase) Length = 1233 Score = 66.6 bits (161), Expect = 6e-11 Identities = 51/188 (27%), Positives = 90/188 (47%), Gaps = 12/188 (6%) Frame = +3 Query: 99 PPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHL-----AVKKLDTSAD 263 P + ++ L L++ F ++G G+YG+VY G+H+ A+K +D + D Sbjct: 6 PAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVY-----KGRHVKTVTAAIKVMDVTED 60 Query: 264 PEPDNEFLTQLSIVSRLKHE-NFVEMLGYCVE------GNQRLVAYEFATMGSLHDILHG 422 E E +++++ + H N G ++ +Q + EF GS+ D++ Sbjct: 61 EE--EEITLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN 118 Query: 423 RKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKV 602 KG + DW+ I+ + +GLA+LH ++HRDI+ NVLL E+ K+ Sbjct: 119 TKGNTLKE-----DWI--AYISREILRGLAHLHIH---HVIHRDIKGQNVLLTENAEVKL 168 Query: 603 ADFNLSNQ 626 DF +S Q Sbjct: 169 VDFGVSAQ 176
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 66.6 bits (161), Expect = 6e-11 Identities = 48/154 (31%), Positives = 78/154 (50%), Gaps = 5/154 (3%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGK---HLAVKKLDTSADPEPDN--EFLTQLSIVSRLKHENFVEM 338 IG GS+G VY GK +AVK L DP P+ F +++++ + +H N + Sbjct: 355 IGSGSFGTVY-----KGKWHGDVAVKILKV-VDPTPEQLQAFRNEVAVLRKTRHVNILLF 408 Query: 339 LGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYL 518 +GY + N +V ++ SL+ LH ++ Q + IA A+G+ YL Sbjct: 409 MGYMTKDNLAIVT-QWCEGSSLYKHLHVQE--------TKFQMFQLIDIARQTAQGMDYL 459 Query: 519 HEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 H K +I+HRD++S+N+ L E K+ DF L+ Sbjct: 460 HAK---NIIHRDMKSNNIFLHEGLTVKIGDFGLA 490
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 66.6 bits (161), Expect = 6e-11 Identities = 48/154 (31%), Positives = 78/154 (50%), Gaps = 5/154 (3%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGK---HLAVKKLDTSADPEPDN--EFLTQLSIVSRLKHENFVEM 338 IG GS+G VY GK +AVK L DP P+ F +++++ + +H N + Sbjct: 355 IGSGSFGTVY-----KGKWHGDVAVKILKV-VDPTPEQLQAFRNEVAVLRKTRHVNILLF 408 Query: 339 LGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYL 518 +GY + N +V ++ SL+ LH ++ Q + IA A+G+ YL Sbjct: 409 MGYMTKDNLAIVT-QWCEGSSLYKHLHVQE--------TKFQMFQLIDIARQTAQGMDYL 459 Query: 519 HEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 H K +I+HRD++S+N+ L E K+ DF L+ Sbjct: 460 HAK---NIIHRDMKSNNIFLHEGLTVKIGDFGLA 490
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 66.6 bits (161), Expect = 6e-11 Identities = 48/154 (31%), Positives = 78/154 (50%), Gaps = 5/154 (3%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGK---HLAVKKLDTSADPEPDN--EFLTQLSIVSRLKHENFVEM 338 IG GS+G VY GK +AVK L DP P+ F +++++ + +H N + Sbjct: 355 IGSGSFGTVY-----KGKWHGDVAVKILKV-VDPTPEQFQAFRNEVAVLRKTRHVNILLF 408 Query: 339 LGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYL 518 +GY + N +V ++ SL+ LH ++ Q + IA A+G+ YL Sbjct: 409 MGYMTKDNLAIVT-QWCEGSSLYKHLHVQE--------TKFQMFQLIDIARQTAQGMDYL 459 Query: 519 HEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 H K +I+HRD++S+N+ L E K+ DF L+ Sbjct: 460 HAK---NIIHRDMKSNNIFLHEGLTVKIGDFGLA 490
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 66.6 bits (161), Expect = 6e-11 Identities = 42/135 (31%), Positives = 75/135 (55%), Gaps = 3/135 (2%) Frame = +3 Query: 171 LIGEGSYGRVYYAILDSGKHLAVKKL--DTSADPEPDNEFLTQLSIVSRLKHENFVEMLG 344 +IG GS+G+VY + K +A+K+ +T + F ++SI+ +L H ++ +G Sbjct: 467 IIGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVG 525 Query: 345 YCV-EGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLH 521 C+ + +Q + ++ + GSL +LH +K + LD ++ IA+D A+G+ YLH Sbjct: 526 ACLNDPSQFAIVTQYISGGSLFSLLHEQKRI--------LDLQSKLIIAVDVARGMEYLH 577 Query: 522 EKVQPSIVHRDIRSS 566 QP I+HRD+ S Sbjct: 578 NLTQP-IIHRDLNRS 591
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 66.6 bits (161), Expect = 6e-11 Identities = 48/154 (31%), Positives = 78/154 (50%), Gaps = 5/154 (3%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGK---HLAVKKLDTSADPEPDN--EFLTQLSIVSRLKHENFVEM 338 IG GS+G VY GK +AVK L DP P+ F +++++ + +H N + Sbjct: 30 IGSGSFGTVY-----KGKWHGDVAVKILKV-VDPTPEQLQAFRNEVAVLRKTRHVNILLF 83 Query: 339 LGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYL 518 +GY + N +V ++ SL+ LH ++ Q + IA A+G+ YL Sbjct: 84 MGYMTKDNLAIVT-QWCEGSSLYKHLHVQE--------TKFQMFQLIDIARQTAQGMDYL 134 Query: 519 HEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 H K +I+HRD++S+N+ L E K+ DF L+ Sbjct: 135 HAK---NIIHRDMKSNNIFLHEGLTVKIGDFGLA 165
>TAOK3_HUMAN (Q9H2K8) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen H Length = 898 Score = 66.6 bits (161), Expect = 6e-11 Identities = 47/155 (30%), Positives = 80/155 (51%), Gaps = 3/155 (1%) Frame = +3 Query: 174 IGEGSYGRVYYAI-LDSGKHLAVKKLDTSADP--EPDNEFLTQLSIVSRLKHENFVEMLG 344 IG GS+G VY+A + + +A+KK+ S E + L ++ + +LKH N +E G Sbjct: 30 IGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKG 89 Query: 345 YCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHE 524 ++ + + E+ +GS D+L K L ++ I A GLAYLH Sbjct: 90 CYLKEHTAWLVMEYC-LGSASDLLEVHK--------KPLQEVEIAAITHGALHGLAYLHS 140 Query: 525 KVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQS 629 +++HRDI++ N+LL E + K+ADF ++ + Sbjct: 141 H---ALIHRDIKAGNILLTEPGQVKLADFGSASMA 172
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 66.6 bits (161), Expect = 6e-11 Identities = 48/154 (31%), Positives = 78/154 (50%), Gaps = 5/154 (3%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGK---HLAVKKLDTSADPEPDN--EFLTQLSIVSRLKHENFVEM 338 IG GS+G VY GK +AVK L DP P+ F +++++ + +H N + Sbjct: 355 IGSGSFGTVY-----KGKWHGDVAVKILKV-VDPTPEQFQAFRNEVAVLRKTRHVNILLF 408 Query: 339 LGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYL 518 +GY + N +V ++ SL+ LH ++ Q + IA A+G+ YL Sbjct: 409 MGYMTKDNLAIVT-QWCEGSSLYKHLHVQE--------TKFQMFQLIDIARQTAQGMDYL 459 Query: 519 HEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 H K +I+HRD++S+N+ L E K+ DF L+ Sbjct: 460 HAK---NIIHRDMKSNNIFLHEGLTVKIGDFGLA 490
>M4K2_HUMAN (Q12851) Mitogen-activated protein kinase kinase kinase kinase 2| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-pro Length = 819 Score = 66.6 bits (161), Expect = 6e-11 Identities = 53/171 (30%), Positives = 81/171 (47%), Gaps = 1/171 (0%) Frame = +3 Query: 117 ELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQ- 293 EL L++ D F +G G+YG VY A LA K+ DP D L Q Sbjct: 2 ELRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKI-VKLDPGDDISSLQQE 60 Query: 294 LSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQ 473 ++I+ +H N V +G + ++ + EF GSL +I H GP L+ Q Sbjct: 61 ITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHA--------TGP-LEERQ 111 Query: 474 RVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 + + KGL +LH + + +HRDI+ +N+LL K+ADF +S + Sbjct: 112 IAYVCRERLKGLHHLHSQGK---IHRDIKGANLLLTLQGDVKLADFGVSGE 159
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 66.6 bits (161), Expect = 6e-11 Identities = 52/186 (27%), Positives = 89/186 (47%), Gaps = 2/186 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA- 260 PT P + L+ D + ++ + +G+G +G V+ + +A+K L Sbjct: 248 PTSKP---QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM 304 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVP 437 PE FL + ++ +L+HE V++ Y V + + + E+ GSL D L G Sbjct: 305 SPEA---FLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVTEYMNKGSLLDFLKG----- 354 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 + G L Q V ++ A G+AY+ + VHRD+R++N+L+ E+ KVADF L Sbjct: 355 --ETGKYLRLPQLVDMSAQIASGMAYVDRM---NYVHRDLRAANILVGENLVCKVADFGL 409 Query: 618 SNQSPD 635 + D Sbjct: 410 ARLIED 415
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 66.2 bits (160), Expect = 8e-11 Identities = 42/154 (27%), Positives = 75/154 (48%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCV 353 +G G +G V+ + ++ +AVK L FL + ++ +L+H++ V++ C Sbjct: 246 LGAGQFGEVWAGVWNNTTQVAVKTLKPGTMSPAS--FLDEAGVMKKLRHKHLVQLYAICS 303 Query: 354 EGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQ 533 + + E+ + GSL D L +GV P + +A A G+A+L + Sbjct: 304 DREPIYIVTEYMSGGSLLDYLSKGEGVNLQLP-------TLIDMAAQVASGMAFLEAQ-- 354 Query: 534 PSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 +HRD+ + N+L+ E+Y KVADF L+ D Sbjct: 355 -GYIHRDLAARNILVGENYICKVADFGLARLIED 387
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 66.2 bits (160), Expect = 8e-11 Identities = 51/182 (28%), Positives = 85/182 (46%), Gaps = 3/182 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDS-GKHLAVKKLDTSA 260 P + P + + D+ + + + K +G G YG VY + +AVK L Sbjct: 167 PKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL--KE 224 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILH--GRKGV 434 D EFL + +++ +KH N V++LG C + EF T G+L D L R+ V Sbjct: 225 DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEV 284 Query: 435 PGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFN 614 + + + +A + + YL +K + +HRD+ + N L+ E++ KVADF Sbjct: 285 ---------NAVVLLYMATQISSAMEYLEKK---NFIHRDLAARNCLVGENHLVKVADFG 332 Query: 615 LS 620 LS Sbjct: 333 LS 334
>RET_HUMAN (P07949) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1114 Score = 66.2 bits (160), Expect = 8e-11 Identities = 46/170 (27%), Positives = 81/170 (47%), Gaps = 21/170 (12%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKH------LAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVE 335 +GEG +G+V A K +AVK L +A P + L++ +++ ++ H + ++ Sbjct: 730 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIK 789 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDILH-------GRKGVPGAQPGPALDWMQR------ 476 + G C + L+ E+A GSL L G G G++ +LD Sbjct: 790 LYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMG 849 Query: 477 --VKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 + A ++G+ YL E +VHRD+ + N+L+ E + K++DF LS Sbjct: 850 DLISFAWQISQGMQYLAEM---KLVHRDLAARNILVAEGRKMKISDFGLS 896
>INSR_MOUSE (P15208) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1372 Score = 66.2 bits (160), Expect = 8e-11 Identities = 48/182 (26%), Positives = 81/182 (44%), Gaps = 7/182 (3%) Frame = +3 Query: 96 PPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAIL------DSGKHLAVKKLDTS 257 P E+P + L+E +G+GS+G VY ++ +AVK ++ S Sbjct: 1003 PDEWEVPREKITLLRE----------LGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNES 1052 Query: 258 ADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVP 437 A EFL + S++ + V +LG +G LV E G L L + Sbjct: 1053 ASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPMLVVMELMAHGDLKSHLRSLRPDA 1112 Query: 438 GAQPG-PALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFN 614 PG P + +++ + A G+AYL+ K VHRD+ + N ++ D+ K+ DF Sbjct: 1113 ENNPGRPPPTLQEMIQMTAEIADGMAYLNAK---KFVHRDLAARNCMVAHDFTVKIGDFG 1169 Query: 615 LS 620 ++ Sbjct: 1170 MT 1171
>KSYK_MOUSE (P48025) Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine| kinase) Length = 629 Score = 66.2 bits (160), Expect = 8e-11 Identities = 58/203 (28%), Positives = 92/203 (45%), Gaps = 7/203 (3%) Frame = +3 Query: 33 PSAQXEKEGNGFDTK--SDPTKAPPPIEIPELSLDE-LKEKTDNFGSKALIGEGSYGRV- 200 P ++E DT+ P P I E+ LD L DN +G G++G V Sbjct: 326 PDRGLQREALPMDTEVYESPYADPEEIRPKEVYLDRSLLTLEDNE-----LGSGNFGTVK 380 Query: 201 --YYAILDSGKHLAVKKLDTSA-DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL 371 YY + K +AVK L A DP +E L + +++ +L + V M+G C E + Sbjct: 381 KGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWM 439 Query: 372 VAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHR 551 + E A +G L+ L + + +++ + G+ YL E + VHR Sbjct: 440 LVMEMAELGPLNKYLQQNRHIKDKNI---------IELVHQVSMGMKYLEES---NFVHR 487 Query: 552 DIRSSNVLLFEDYRAKVADFNLS 620 D+ + NVLL + AK++DF LS Sbjct: 488 DLAARNVLLVTQHYAKISDFGLS 510
>TAOK3_PONPY (Q5R4F3) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 66.2 bits (160), Expect = 8e-11 Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 174 IGEGSYGRVYYAI-LDSGKHLAVKKLDTSADP--EPDNEFLTQLSIVSRLKHENFVEMLG 344 IG GS+G VY+A + + +A+KK+ S E + L ++ + +LKH N +E G Sbjct: 30 IGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKG 89 Query: 345 YCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHE 524 ++ + + E+ +GS D+L K L ++ I A GLAYLH Sbjct: 90 CYLKEHTAWLVMEYC-LGSASDLLEVHK--------KPLQEVEIAAITHGALHGLAYLHS 140 Query: 525 KVQPSIVHRDIRSSNVLLFEDYRAKVADF 611 +++HRDI++ N+LL E + K+ADF Sbjct: 141 H---ALIHRDIKAGNILLTEPGQVKLADF 166
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 66.2 bits (160), Expect = 8e-11 Identities = 52/178 (29%), Positives = 83/178 (46%), Gaps = 2/178 (1%) Frame = +3 Query: 108 EIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA-DPEPDNEF 284 EIP SL +K +G G +G V+ + +A+K L PE F Sbjct: 264 EIPRESLQLIKR----------LGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPE---SF 310 Query: 285 LTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVPGAQPGPAL 461 L + I+ +LKH+ V++ Y V + + + E+ + GSL D L +G AL Sbjct: 311 LEEAQIMKKLKHDKLVQL--YAVVSEEPIYIVTEYMSKGSLLDFLKDGEG-------RAL 361 Query: 462 DWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 V +A A+G+AY+ + +HRD+RS+N+L+ K+ADF L+ D Sbjct: 362 KLPNLVDMAAQVARGMAYIERM---NYIHRDLRSANILVGNGLICKIADFGLARLIED 416
>PAKM_DROME (Q9VXE5) Serine/threonine-protein kinase PAK mbt (EC 2.7.11.1)| (p21-activated kinase-related protein) (Protein mushroom bodies tiny) Length = 639 Score = 66.2 bits (160), Expect = 8e-11 Identities = 54/171 (31%), Positives = 81/171 (47%), Gaps = 2/171 (1%) Frame = +3 Query: 120 LSLDELKEKTDNFGSKALIGEGSYGRVYYAILDS-GKHLAVKKLDTSADPEPDNEFLTQL 296 +S + +E D+F IGEGS G V A S G+ +AVKK+D + F ++ Sbjct: 359 VSAGDPRENLDHFNK---IGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLF-NEV 414 Query: 297 SIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDIL-HGRKGVPGAQPGPALDWMQ 473 I+ H N VE + ++ V E+ G+L DI+ H R +D Q Sbjct: 415 VIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHSR-----------MDEEQ 463 Query: 474 RVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 + K LAYLH + ++HRDI+S ++LL D R K++DF Q Sbjct: 464 IATVCKQCLKALAYLHSQ---GVIHRDIKSDSILLAADGRVKLSDFGFCAQ 511
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 66.2 bits (160), Expect = 8e-11 Identities = 51/182 (28%), Positives = 85/182 (46%), Gaps = 3/182 (1%) Frame = +3 Query: 84 PTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDS-GKHLAVKKLDTSA 260 P + P + + D+ + + + K +G G YG VY + +AVK L Sbjct: 218 PKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL--KE 275 Query: 261 DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILH--GRKGV 434 D EFL + +++ +KH N V++LG C + EF T G+L D L R+ V Sbjct: 276 DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEV 335 Query: 435 PGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFN 614 + + + +A + + YL +K + +HRD+ + N L+ E++ KVADF Sbjct: 336 ---------NAVVLLYMATQISSAMEYLEKK---NFIHRDLAARNCLVGENHLVKVADFG 383 Query: 615 LS 620 LS Sbjct: 384 LS 385
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 66.2 bits (160), Expect = 8e-11 Identities = 46/155 (29%), Positives = 81/155 (52%), Gaps = 5/155 (3%) Frame = +3 Query: 171 LIGEGSYGRVYYAI-LDSGKHL----AVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVE 335 ++G G++G VY I + G+ + A+K L+ + P+ + EF+ + I++ + H + V Sbjct: 723 VLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVR 782 Query: 336 MLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAY 515 +LG C+ +LV + G L + +H K G+Q L+W + AKG+ Y Sbjct: 783 LLGVCLSPTIQLVT-QLMPHGCLLEYVHEHKDNIGSQ--LLLNW------CVQIAKGMMY 833 Query: 516 LHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 L E+ +VHRD+ + NVL+ K+ DF L+ Sbjct: 834 LEER---RLVHRDLAARNVLVKSPNHVKITDFGLA 865
>PAK7_HUMAN (Q9P286) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (PAK-5) Length = 719 Score = 65.9 bits (159), Expect = 1e-10 Identities = 49/153 (32%), Positives = 77/153 (50%), Gaps = 2/153 (1%) Frame = +3 Query: 174 IGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYC 350 IGEGS G V A +GK +AVKK+D + F ++ I+ H+N V+M Sbjct: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLF-NEVVIMRDYHHDNVVDMYSSY 513 Query: 351 VEGNQRLVAYEFATMGSLHDIL-HGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 + G++ V EF G+L DI+ H R ++ Q + + + L+YLH + Sbjct: 514 LVGDELWVVMEFLEGGALTDIVTHTR-----------MNEEQIATVCLSVLRALSYLHNQ 562 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 ++HRDI+S ++LL D R K++DF Q Sbjct: 563 ---GVIHRDIKSDSILLTSDGRIKLSDFGFCAQ 592
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 65.9 bits (159), Expect = 1e-10 Identities = 45/154 (29%), Positives = 73/154 (47%) Frame = +3 Query: 174 IGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGYCV 353 +G G++G V+Y + +AVK L FL + +I+ + +H V + C Sbjct: 290 LGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTA--AFLQEAAIMKKFRHNRLVALYAVCS 347 Query: 354 EGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQ 533 + + E+ + GSL D L R+G G L + + IA A G+ YL K Sbjct: 348 QEEPIYIVQEYMSKGSLLDFL--REG-----DGRYLHFEDLIYIATQVASGMEYLESK-- 398 Query: 534 PSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 ++HRD+ + NVL+ E+ AK+ DF L+ D Sbjct: 399 -QLIHRDLAARNVLIGENNVAKICDFGLARVIAD 431
>TAOK2_XENLA (Q6GPK9) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1025 Score = 65.9 bits (159), Expect = 1e-10 Identities = 49/171 (28%), Positives = 84/171 (49%), Gaps = 3/171 (1%) Frame = +3 Query: 108 EIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDN-- 278 E+ EL + EK F IG GS+G VY+A + + + +A+KK+ S + Sbjct: 14 EVAELFFKDDPEKL--FADLREIGHGSFGAVYFARDIRNNEVVAIKKMSYSGKQSNEKWQ 71 Query: 279 EFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPA 458 + + ++ + +L+H N +E G + + + E+ +GS D+L K Sbjct: 72 DIIKEVKFLQKLRHPNTIEYKGCYLREHTAWLVMEYC-LGSASDLLEVHK--------KP 122 Query: 459 LDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADF 611 L M+ I A +GLAYLH +++HRD+++ N+LL E K+ DF Sbjct: 123 LQEMEIAAITHGALQGLAYLHNH---NMIHRDVKAGNILLTEPGLVKLGDF 170
>KSYK_RAT (Q64725) Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine| kinase) Length = 629 Score = 65.9 bits (159), Expect = 1e-10 Identities = 58/203 (28%), Positives = 92/203 (45%), Gaps = 7/203 (3%) Frame = +3 Query: 33 PSAQXEKEGNGFDTK--SDPTKAPPPIEIPELSLD-ELKEKTDNFGSKALIGEGSYGRV- 200 P ++E DT+ P P I E+ LD +L DN +G G++G V Sbjct: 326 PDRGLQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDNE-----LGSGNFGTVK 380 Query: 201 --YYAILDSGKHLAVKKLDTSA-DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRL 371 YY + K +AVK L A DP +E L + +++ +L + V M+G C E + Sbjct: 381 KGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWM 439 Query: 372 VAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHR 551 + E A G L+ L + + +++ + G+ YL E + VHR Sbjct: 440 LVMEMAAWGPLNKYLQQNRHIKDKNI---------IELVHQVSMGMKYLEES---NFVHR 487 Query: 552 DIRSSNVLLFEDYRAKVADFNLS 620 D+ + NVLL + AK++DF LS Sbjct: 488 DLAARNVLLVTQHYAKISDFGLS 510
>CDKL2_MACFA (Q4R7T5) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 570 Score = 65.9 bits (159), Expect = 1e-10 Identities = 47/162 (29%), Positives = 79/162 (48%), Gaps = 2/162 (1%) Frame = +3 Query: 141 EKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKK-LDTSADPEPDNEFLTQLSIVSRL 314 EK +N G L+GEGSYG V D+G+ +A+KK L++ D + ++ ++ +L Sbjct: 2 EKYENLG---LVGEGSYGMVVKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQL 58 Query: 315 KHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAID 494 +HEN V +L C + + + +EF H IL + P LD+ K Sbjct: 59 RHENLVNLLEVCKKKKRWYLVFEFVD----HTILDDLELFPN-----GLDYQVVQKYLFQ 109 Query: 495 AAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 G+ + H +I+HRDI+ N+L+ + K+ DF + Sbjct: 110 IINGIGFCHSH---NIIHRDIKPENILVSQSGVVKLCDFGFA 148
>CDKL2_HUMAN (Q92772) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE) Length = 493 Score = 65.9 bits (159), Expect = 1e-10 Identities = 47/162 (29%), Positives = 79/162 (48%), Gaps = 2/162 (1%) Frame = +3 Query: 141 EKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKK-LDTSADPEPDNEFLTQLSIVSRL 314 EK +N G L+GEGSYG V D+G+ +A+KK L++ D + ++ ++ +L Sbjct: 2 EKYENLG---LVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQL 58 Query: 315 KHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAID 494 +HEN V +L C + + + +EF H IL + P LD+ K Sbjct: 59 RHENLVNLLEVCKKKKRWYLVFEFVD----HTILDDLELFPN-----GLDYQVVQKYLFQ 109 Query: 495 AAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 G+ + H +I+HRDI+ N+L+ + K+ DF + Sbjct: 110 IINGIGFCHSH---NIIHRDIKPENILVSQSGVVKLCDFGFA 148
>STK24_MOUSE (Q99KH8) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| Length = 431 Score = 65.9 bits (159), Expect = 1e-10 Identities = 51/183 (27%), Positives = 91/183 (49%), Gaps = 2/183 (1%) Frame = +3 Query: 93 APPPIEIPELSLDELKEKTDNFGSKA-LIGEGSYGRVYYAILD-SGKHLAVKKLDTSADP 266 A P++ + LK + +K IG+GS+G V+ I + + K +A+K +D Sbjct: 2 AHSPVQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAE 61 Query: 267 EPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQ 446 + + +++++S+ + G ++ + + E+ GS D+L + Sbjct: 62 DEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL---------E 112 Query: 447 PGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 PGP LD +Q I + KGL YLH + + +HRDI+++NVLL E K+ADF ++ Q Sbjct: 113 PGP-LDEIQIATILREILKGLDYLHSEKK---IHRDIKAANVLLSEHGEVKLADFGVAGQ 168 Query: 627 SPD 635 D Sbjct: 169 LTD 171
>SHK2_SCHPO (Q10056) Serine/threonine-protein kinase shk2 (EC 2.7.11.1)| Length = 589 Score = 65.5 bits (158), Expect = 1e-10 Identities = 51/174 (29%), Positives = 80/174 (45%), Gaps = 11/174 (6%) Frame = +3 Query: 141 EKTDNFGSKALIGEGSYGRVYYAILDSGKHL------AVKKLDTSADPEPDNEFLTQLSI 302 + + F K +G+G+ G VY A + GK L A+K +D + L ++++ Sbjct: 304 DPVEYFNVKHKLGQGASGSVYLAKVVGGKQLGIFDSVAIKSIDLQCQTRKEL-ILNEITV 362 Query: 303 VSRLKHENFVEML-GYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRV 479 + H N V L + V V E+ GSL DI+ K L Q Sbjct: 363 MRESIHPNIVTYLDSFLVRERHLWVVMEYMNAGSLTDIIEKSK----------LTEAQIA 412 Query: 480 KIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADF----NLSNQS 629 +I ++ KG+ +LH + +I+HRDI+S NVLL K+ DF LSN++ Sbjct: 413 RICLETCKGIQHLHAR---NIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRT 463
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 65.5 bits (158), Expect = 1e-10 Identities = 46/161 (28%), Positives = 73/161 (45%), Gaps = 12/161 (7%) Frame = +3 Query: 174 IGEGSYGRVYYA-----ILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +GEG++G+V+ A + D K L K +F + +++ L+H++ V Sbjct: 519 LGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRF 578 Query: 339 LGYCVEGNQRLVAYEFATMGSLHDIL--HG-----RKGVPGAQPGPALDWMQRVKIAIDA 497 G C EG L+ +E+ G L+ L HG G PGP L Q + +A Sbjct: 579 FGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP-LGLGQLLAVASQV 637 Query: 498 AKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A G+ YL VHRD+ + N L+ + K+ DF +S Sbjct: 638 AAGMVYL---ASLHFVHRDLATRNCLVGQGLVVKIGDFGMS 675
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 65.5 bits (158), Expect = 1e-10 Identities = 48/152 (31%), Positives = 81/152 (53%), Gaps = 1/152 (0%) Frame = +3 Query: 168 ALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGY 347 A IGEG +G V G+ +AVK + + FL + +++++++HEN V +LG Sbjct: 239 AQIGEGEFGAVLQGEY-LGQKVAVKNIKCDVTAQA---FLDETAVMTKMQHENLVRLLGV 294 Query: 348 CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPAL-DWMQRVKIAIDAAKGLAYLHE 524 + +V E + G+L + L R G AL + Q ++ ++ A+G+ YL Sbjct: 295 ILHQGLYIVM-EHVSKGNLVNFLRTR--------GRALVNTAQLLQFSLHVAEGMEYLES 345 Query: 525 KVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 K +VHRD+ + N+L+ ED AKV+DF L+ Sbjct: 346 K---KLVHRDLAARNILVSEDLVAKVSDFGLA 374
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 65.5 bits (158), Expect = 1e-10 Identities = 46/160 (28%), Positives = 78/160 (48%), Gaps = 7/160 (4%) Frame = +3 Query: 174 IGEGSYGRVYYAILD-----SGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +G+G++G V D +G+ +AVKKL S + E +F ++ I+ L+H+N V+ Sbjct: 855 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTE-EHLRDFEREIEILKSLQHDNIVKY 913 Query: 339 LGYCVEGNQR--LVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLA 512 G C +R + E+ GSL D L K +D ++ ++ KG+ Sbjct: 914 KGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK--------ERIDHIKLLQYTSQICKGME 965 Query: 513 YLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSP 632 YL K +HRD+ + N+L+ + R K+ DF L+ P Sbjct: 966 YLGTK---RYIHRDLATRNILVENENRVKIGDFGLTKVLP 1002 Score = 45.4 bits (106), Expect = 1e-04 Identities = 34/153 (22%), Positives = 72/153 (47%), Gaps = 8/153 (5%) Frame = +3 Query: 174 IGEGSYGRVYYAIL----DSGK----HLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENF 329 +G+G++ +++ + D G+ + +K LD A F S++S+L H++ Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLD-KAHRNYSESFFEAASMMSKLSHKHL 609 Query: 330 VEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGL 509 V G CV G++ ++ EF GSL L K ++ + ++++A A + Sbjct: 610 VLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN--------CINILWKLEVAKQLAWAM 661 Query: 510 AYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVAD 608 +L E +++H ++ + N+LL + K + Sbjct: 662 HFLEEN---TLIHGNVCAKNILLIREEDRKTGN 691
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 65.5 bits (158), Expect = 1e-10 Identities = 44/175 (25%), Positives = 80/175 (45%), Gaps = 3/175 (1%) Frame = +3 Query: 120 LSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNE---FLT 290 +S + E T +F LIGEG VY + + + AVK + FL+ Sbjct: 166 ISFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRNQAY-AVKLFKQEKKMQLKKHWKRFLS 224 Query: 291 QLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWM 470 +L ++ +H + +E+ Y E + + Y + + G+L D L G L W Sbjct: 225 ELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTT------PLSWH 278 Query: 471 QRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 R+ + I AK + YLH +++ ++ S+N+LL + + K+ DF ++ P+ Sbjct: 279 VRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPN 333
>CDKL2_PONPY (Q5R754) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 493 Score = 65.5 bits (158), Expect = 1e-10 Identities = 47/162 (29%), Positives = 79/162 (48%), Gaps = 2/162 (1%) Frame = +3 Query: 141 EKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKK-LDTSADPEPDNEFLTQLSIVSRL 314 EK +N G L+GEGSYG V D+G+ +A+KK L++ D + ++ ++ +L Sbjct: 2 EKYENLG---LVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQL 58 Query: 315 KHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAID 494 +HEN V +L C + + + +EF H IL + P LD+ K Sbjct: 59 RHENLVNLLEVCKKKKRWYLVFEFVD----HTILDDLELFPN-----GLDYQVVQKYLFQ 109 Query: 495 AAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 G+ + H +I+HRDI+ N+L+ + K+ DF + Sbjct: 110 IINGIGFCHSH---NIIHRDIKPENILVSKSGVVKLCDFGFA 148
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 65.5 bits (158), Expect = 1e-10 Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 1/156 (0%) Frame = +3 Query: 171 LIGEGSYGR-VYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGY 347 ++G+G +G+ + ++G+ + +K+L D E FL ++ ++ L+H N ++ +G Sbjct: 351 VLGKGCFGQAIKVTHRETGEVMVMKEL-IRFDEETQRTFLKEVKVMRCLEHPNVLKFIGV 409 Query: 348 CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHEK 527 + + E+ G+L ++ K + P W QRV A D A G+AYLH Sbjct: 410 LYKEKRLNFITEYIKGGTLRGLI---KSMDSHYP-----WSQRVSFAKDIAAGMAYLHSM 461 Query: 528 VQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 +I+HRD+ S N L+ E+ VADF L+ D Sbjct: 462 ---NIIHRDLNSHNCLVRENKSVVVADFGLARLMVD 494
>MINK1_HUMAN (Q8N4C8) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1332 Score = 65.1 bits (157), Expect = 2e-10 Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 8/184 (4%) Frame = +3 Query: 99 PPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPD 275 P + ++ L L++ F ++G G+YG+VY + +G+ A+K +D + D E Sbjct: 6 PARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-- 63 Query: 276 NEFLTQLSIVSRLKHE-NFVEMLGYCVE----GN--QRLVAYEFATMGSLHDILHGRKGV 434 E +++++ + H N G ++ GN Q + EF GS+ D++ KG Sbjct: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKG- 122 Query: 435 PGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFN 614 AL I + +GLA+LH ++HRDI+ NVLL E+ K+ DF Sbjct: 123 ------NALKEDCIAYICREILRGLAHLHAH---KVIHRDIKGQNVLLTENAEVKLVDFG 173 Query: 615 LSNQ 626 +S Q Sbjct: 174 VSAQ 177
>MINK1_MOUSE (Q9JM52) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1308 Score = 65.1 bits (157), Expect = 2e-10 Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 8/184 (4%) Frame = +3 Query: 99 PPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPD 275 P + ++ L L++ F ++G G+YG+VY + +G+ A+K +D + D E Sbjct: 6 PARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-- 63 Query: 276 NEFLTQLSIVSRLKHE-NFVEMLGYCVE----GN--QRLVAYEFATMGSLHDILHGRKGV 434 E +++++ + H N G ++ GN Q + EF GS+ D++ KG Sbjct: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKG- 122 Query: 435 PGAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFN 614 AL I + +GLA+LH ++HRDI+ NVLL E+ K+ DF Sbjct: 123 ------NALKEDCIAYICREILRGLAHLHAH---KVIHRDIKGQNVLLTENAEVKLVDFG 173 Query: 615 LSNQ 626 +S Q Sbjct: 174 VSAQ 177
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 65.1 bits (157), Expect = 2e-10 Identities = 51/181 (28%), Positives = 84/181 (46%), Gaps = 6/181 (3%) Frame = +3 Query: 96 PPPIEIPELSLDELKEKTDNFGSKA--LIGEGSYGRVYYAILDS-GKH---LAVKKLDTS 257 P E P ++ E ++ D K +IG G +G V + L GK +A+K L + Sbjct: 615 PSTYEDPNEAIREFAKEIDVSFIKIEEVIGSGEFGEVCFGRLKHPGKREYTVAIKTLKSG 674 Query: 258 ADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVP 437 E EFL++ SI+ + +H N + + G + ++ EF GSL L ++G Sbjct: 675 YTDEQRREFLSEASIMGQFEHPNVIHLEGVVTKSRPVMIVTEFMENGSLDSFLRQKEG-- 732 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 +Q V + A G+ YL + + VHRD+ + N+L+ + KV+DF L Sbjct: 733 ------QFSVLQLVGMLRGIAAGMRYLSDM---NYVHRDLAARNILVNSNLVCKVSDFGL 783 Query: 618 S 620 S Sbjct: 784 S 784
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 65.1 bits (157), Expect = 2e-10 Identities = 60/214 (28%), Positives = 105/214 (49%), Gaps = 17/214 (7%) Frame = +3 Query: 36 SAQXEKEGNGFDTKSDPT--KAPPPIEIPELSLDE---LKEKTDNFGSK----ALIGEGS 188 SA + F S P+ + P PI + ++ L+E TD+ K ALIG GS Sbjct: 345 SAHGNHQVLSFSPGSSPSFIEQPSPISPTSTTSEDTNTLEEDTDDQSIKWIRGALIGSGS 404 Query: 189 YGRVYYAI-LDSGKHLAVKK--LDTSADPEPDNEFLT-----QLSIVSRLKHENFVEMLG 344 +G+VY + SG+ +AVK+ LD+ ++ + + L +++++ L HE+ V+ LG Sbjct: 405 FGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHIVQYLG 464 Query: 345 YCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHE 524 + + + E+ GS+ +L G + + + I KGL YLH Sbjct: 465 SNLNSDHLNIFLEYVPGGSVAGLL--------TMYGSFEETLVKNFIK-QTLKGLEYLHS 515 Query: 525 KVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQ 626 + IVHRDI+ +N+L+ + K++DF +S + Sbjct: 516 R---GIVHRDIKGANILVDNKGKIKISDFGISKK 546
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 65.1 bits (157), Expect = 2e-10 Identities = 49/152 (32%), Positives = 79/152 (51%), Gaps = 1/152 (0%) Frame = +3 Query: 168 ALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGY 347 A IGEG +G V G+ +AVK + + FL + +++++L+H N V +LG Sbjct: 237 AQIGEGEFGAVLQGEY-LGQKVAVKNIKCDVTAQA---FLDETAVMTKLQHRNLVRLLGV 292 Query: 348 CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPAL-DWMQRVKIAIDAAKGLAYLHE 524 + +V E + G+L + L R G AL Q ++ A+ A+G+ YL Sbjct: 293 ILHHGLYIVM-EHVSKGNLVNFLRTR--------GRALVSTSQLLQFALHVAEGMEYLES 343 Query: 525 KVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 K +VHRD+ + N+L+ ED AKV+DF L+ Sbjct: 344 K---KLVHRDLAARNILVSEDLVAKVSDFGLA 372
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 65.1 bits (157), Expect = 2e-10 Identities = 49/152 (32%), Positives = 79/152 (51%), Gaps = 1/152 (0%) Frame = +3 Query: 168 ALIGEGSYGRVYYAILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEMLGY 347 A IGEG +G V G+ +AVK + + FL + +++++L+H N V +LG Sbjct: 198 AQIGEGEFGAVLQGEY-LGQKVAVKNIKCDVTAQA---FLDETAVMTKLQHRNLVRLLGV 253 Query: 348 CVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPAL-DWMQRVKIAIDAAKGLAYLHE 524 + +V E + G+L + L R G AL Q ++ A+ A+G+ YL Sbjct: 254 ILHHGLYIVM-EHVSKGNLVNFLRTR--------GRALVSTSQLLQFALHVAEGMEYLES 304 Query: 525 KVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 K +VHRD+ + N+L+ ED AKV+DF L+ Sbjct: 305 K---KLVHRDLAARNILVSEDLVAKVSDFGLA 333
>IGF1R_MOUSE (Q60751) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1373 Score = 65.1 bits (157), Expect = 2e-10 Identities = 46/176 (26%), Positives = 81/176 (46%), Gaps = 12/176 (6%) Frame = +3 Query: 129 DELKEKTDNFGSKALIGEGSYGRVYYAIL------DSGKHLAVKKLDTSADPEPDNEFLT 290 DE + + +G+GS+G VY + + +A+K ++ +A EFL Sbjct: 991 DEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1050 Query: 291 QLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPG------ 452 + S++ + V +LG +G LV E T G L L + P + Sbjct: 1051 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR--PEVEQNNLVLIP 1108 Query: 453 PALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 P+L M +++A + A G+AYL+ VHRD+ + N ++ ED+ K+ DF ++ Sbjct: 1109 PSLSKM--IQMAGEIADGMAYLNAN---KFVHRDLAARNCMVAEDFTVKIGDFGMT 1159
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 65.1 bits (157), Expect = 2e-10 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 17/166 (10%) Frame = +3 Query: 174 IGEGSYGRVYYAI---LDSGKH-----LAVKKLDTSADPEPDNEFLTQLSIVSRL-KHEN 326 +GEG +G+V A +D K +AVK L A + ++ ++++ ++ + KH+N Sbjct: 487 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 546 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQ--------PGPALDWMQRVK 482 + +LG C + V E+A+ G+L + L R+ PG + P + + V Sbjct: 547 IINLLGACTQDGPLYVIVEYASKGNLREYLRARR-PPGMEYSYDINRVPEEQMTFKDLVS 605 Query: 483 IAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A+G+ YL +HRD+ + NVL+ E+ K+ADF L+ Sbjct: 606 CTYQLARGMEYL---ASQKCIHRDLAARNVLVTENNVMKIADFGLA 648
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 65.1 bits (157), Expect = 2e-10 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 17/166 (10%) Frame = +3 Query: 174 IGEGSYGRVYYAI---LDSGKH-----LAVKKLDTSADPEPDNEFLTQLSIVSRL-KHEN 326 +GEG +G+V A +D K +AVK L A + ++ ++++ ++ + KH+N Sbjct: 487 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 546 Query: 327 FVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQ--------PGPALDWMQRVK 482 + +LG C + V E+A+ G+L + L R+ PG + P + + V Sbjct: 547 IINLLGACTQDGPLYVIVEYASKGNLREYLRARR-PPGMEYSYDINRVPEEQMTFKDLVS 605 Query: 483 IAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A+G+ YL +HRD+ + NVL+ E+ K+ADF L+ Sbjct: 606 CTYQLARGMEYL---ASQKCIHRDLAARNVLVTENNVMKIADFGLA 648
>FGFR2_DROME (Q09147) Fibroblast growth factor receptor homolog 2 precursor (EC| 2.7.10.1) (Protein breathless) (dFGF-R1) Length = 1052 Score = 65.1 bits (157), Expect = 2e-10 Identities = 60/230 (26%), Positives = 97/230 (42%), Gaps = 27/230 (11%) Frame = +3 Query: 27 EFPSAQXEKEGNGFDTK----SDPTKAPPPIEIPELSLDELKEKTDNFGSKALIGEGSYG 194 + P + EK+ T +DP + E P S E+ + + GS ++GEG++G Sbjct: 667 QMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGS--ILGEGAFG 724 Query: 195 RVYYAILDS-------GKHLAVKKLDTSADPEPDNEFLTQLSIVSRL--KHENFVEMLGY 347 RV A + + + K+ + D L + V ++ KH N + +LG Sbjct: 725 RVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGC 784 Query: 348 CVEGNQRLVAYEFATMGSLHDIL-HGRKGVPGAQPGPA-------------LDWMQRVKI 485 C +G V E+A G+L D L R G P + L + K Sbjct: 785 CSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKF 844 Query: 486 AIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 A A+G+ YL + +HRD+ + NVL+ + Y K+ADF L+ D Sbjct: 845 AFQIARGMEYLASR---RCIHRDLAARNVLVSDGYVMKIADFGLARDIQD 891
>TAOK3_CHICK (Q9I9E0) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Kinase from chicken) Length = 898 Score = 65.1 bits (157), Expect = 2e-10 Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +3 Query: 174 IGEGSYGRVYYAILD-SGKHLAVKKLDTSADP--EPDNEFLTQLSIVSRLKHENFVEMLG 344 IG GS+G VY+A + + +AVKK+ S E + + ++ + +LKH N +E G Sbjct: 30 IGHGSFGAVYFATNSHTNEVVAVKKMSYSGKQTNEKWQDIIKEVKFLQQLKHPNTIEYKG 89 Query: 345 YCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALDWMQRVKIAIDAAKGLAYLHE 524 ++ + + E+ +GS D+L K L ++ I A +GLAYLH Sbjct: 90 CYLKEHTAWLVMEYC-LGSASDMLEVHK--------KPLQEVEIAAITHGALQGLAYLHS 140 Query: 525 KVQPSIVHRDIRSSNVLLFEDYRAKVADF 611 + +HRDI++ N+LL E + K+ADF Sbjct: 141 HCK---IHRDIKAGNILLTEPGQVKLADF 166
>INSR_RAT (P15127) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1383 Score = 65.1 bits (157), Expect = 2e-10 Identities = 48/182 (26%), Positives = 80/182 (43%), Gaps = 7/182 (3%) Frame = +3 Query: 96 PPPIEIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAIL------DSGKHLAVKKLDTS 257 P E+P + L+E +G+GS+G VY + +AVK ++ S Sbjct: 1014 PDEWEVPREKITLLRE----------LGQGSFGMVYEGNAKDIIKGEVETRVAVKTVNES 1063 Query: 258 ADPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVP 437 A EFL + S++ + V +LG +G LV E G L L + Sbjct: 1064 ASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDA 1123 Query: 438 GAQPG-PALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFN 614 PG P + +++ + A G+AYL+ K VHRD+ + N ++ D+ K+ DF Sbjct: 1124 ENNPGRPPPTLQEMIQMTAEIADGMAYLNAK---KFVHRDLAARNCMVAHDFTVKIGDFG 1180 Query: 615 LS 620 ++ Sbjct: 1181 MT 1182
>IGF1R_RAT (P24062) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1370 Score = 65.1 bits (157), Expect = 2e-10 Identities = 46/175 (26%), Positives = 81/175 (46%), Gaps = 11/175 (6%) Frame = +3 Query: 129 DELKEKTDNFGSKALIGEGSYGRVYYAIL------DSGKHLAVKKLDTSADPEPDNEFLT 290 DE + + +G+GS+G VY + + +A+K ++ +A EFL Sbjct: 991 DEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1050 Query: 291 QLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPG-----P 455 + S++ + V +LG +G LV E T G L L + P + P Sbjct: 1051 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR--PEVENNLVLIPP 1108 Query: 456 ALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 +L M +++A + A G+AYL+ VHRD+ + N ++ ED+ K+ DF ++ Sbjct: 1109 SLSKM--IQMAGEIADGMAYLNAN---KFVHRDLAARNCMVAEDFTVKIGDFGMT 1158
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 65.1 bits (157), Expect = 2e-10 Identities = 52/178 (29%), Positives = 84/178 (47%), Gaps = 2/178 (1%) Frame = +3 Query: 108 EIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAILDSGKHLAVKKLDTSA-DPEPDNEF 284 EIP SL +K +G G +G V+ + +AVK L PE F Sbjct: 264 EIPRESLQLIKR----------LGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPE---SF 310 Query: 285 LTQLSIVSRLKHENFVEMLGYCVEGNQRL-VAYEFATMGSLHDILHGRKGVPGAQPGPAL 461 L + I+ +L+H+ V++ Y V + + + E+ + GSL D L +G AL Sbjct: 311 LEEAQIMKKLRHDKLVQL--YAVVSEEPIYIVTEYMSKGSLLDFLKDGEG-------RAL 361 Query: 462 DWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 V +A A G+AY+ + +HRD+RS+N+L+ ++ K+ADF L+ D Sbjct: 362 KLPNLVDMAAQVAAGMAYIERM---NYIHRDLRSANILVGDNLVCKIADFGLARLIED 416
>KSYK_HUMAN (P43405) Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine| kinase) Length = 635 Score = 65.1 bits (157), Expect = 2e-10 Identities = 52/181 (28%), Positives = 84/181 (46%), Gaps = 10/181 (5%) Frame = +3 Query: 108 EIPELSLDELKEKTDNFGSKAL------IGEGSYGRV---YYAILDSGKHLAVKKLDTSA 260 E P +E++ K K L +G G++G V YY + K +AVK L A Sbjct: 349 ESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA 408 Query: 261 -DPEPDNEFLTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVP 437 DP +E L + +++ +L + V M+G C E ++ E A +G L+ L + V Sbjct: 409 NDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVK 467 Query: 438 GAQPGPALDWMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNL 617 +++ + G+ YL E + VHRD+ + NVLL + AK++DF L Sbjct: 468 DKNI---------IELVHQVSMGMKYLEES---NFVHRDLAARNVLLVTQHYAKISDFGL 515 Query: 618 S 620 S Sbjct: 516 S 516
>HIPPO_DROME (Q8T0S6) Serine/threonine-protein kinase hippo (EC 2.7.11.1)| Length = 669 Score = 65.1 bits (157), Expect = 2e-10 Identities = 53/177 (29%), Positives = 88/177 (49%), Gaps = 1/177 (0%) Frame = +3 Query: 108 EIPELSLDELKEKTDNFGSKALIGEGSYGRVYYAI-LDSGKHLAVKKLDTSADPEPDNEF 284 ++ E SL + EK + K +GEGSYG VY A+ +S +A+K + +D +E Sbjct: 28 KLSEESLLQPPEKVFDIMYK--LGEGSYGSVYKAVHKESSSIVAIKLVPVESDL---HEI 82 Query: 285 LTQLSIVSRLKHENFVEMLGYCVEGNQRLVAYEFATMGSLHDILHGRKGVPGAQPGPALD 464 + ++SI+ + V G + + E+ GS+ DI+ RK L Sbjct: 83 IKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRK--------KTLT 134 Query: 465 WMQRVKIAIDAAKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLSNQSPD 635 + I D +GL YLH + + +HRDI+++N+LL + AK+ADF ++ Q D Sbjct: 135 EDEIATILSDTLQGLVYLHLRRK---IHRDIKAANILLNTEGYAKLADFGVAGQLTD 188
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 65.1 bits (157), Expect = 2e-10 Identities = 46/161 (28%), Positives = 74/161 (45%), Gaps = 12/161 (7%) Frame = +3 Query: 174 IGEGSYGRVYYA-----ILDSGKHLAVKKLDTSADPEPDNEFLTQLSIVSRLKHENFVEM 338 +GEG++G+V+ A + + K L K A +F + +++ L+H++ V Sbjct: 516 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRF 575 Query: 339 LGYCVEGNQRLVAYEFATMGSLHDIL--HG-----RKGVPGAQPGPALDWMQRVKIAIDA 497 G C EG L+ +E+ G L+ L HG G PGP L Q + +A Sbjct: 576 FGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP-LGLGQLLAVASQV 634 Query: 498 AKGLAYLHEKVQPSIVHRDIRSSNVLLFEDYRAKVADFNLS 620 A G+ YL VHRD+ + N L+ + K+ DF +S Sbjct: 635 AAGMVYL---AGLHFVHRDLATRNCLVGQGLVVKIGDFGMS 672 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 92,875,689 Number of Sequences: 219361 Number of extensions: 1930860 Number of successful extensions: 8620 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 7177 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7591 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5938641176 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
