ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bah63n16 |
|---|---|
| Clone Library Name | barley_pub |
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 148 bits (374), Expect = 1e-35 Identities = 81/162 (50%), Positives = 106/162 (65%), Gaps = 2/162 (1%) Frame = +1 Query: 160 RYAYTDIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVST 339 RY+Y +++ TR F+ +LG+G GTVYKGVL D HVAVK LE N E F +E+S Sbjct: 523 RYSYRELVKATRKFKVELGRGESGTVYKGVL-EDDRHVAVKKLE-NVRQGKEVFQAELSV 580 Query: 340 IGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSF--SWDKLNEIALGIA 513 IGRI+H+N+V + GFCSE R LV EY+ NGS+ +FS + W+ IALG+A Sbjct: 581 IGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANILFSEGGNILLDWEGRFNIALGVA 640 Query: 514 RGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 +G+ YLH C ++H D+KP NILLD F PK+ DFGL KL Sbjct: 641 KGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFGLVKL 682
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 143 bits (360), Expect = 5e-34 Identities = 76/160 (47%), Positives = 103/160 (64%), Gaps = 5/160 (3%) Frame = +1 Query: 175 DIIAITRHFRDK--LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGR 348 DI+ T HF K +G GG+GTVYK L PG+ VAVK L E +F++E+ T+G+ Sbjct: 909 DIVEATDHFSKKNIIGDGGFGTVYKACL-PGEKTVAVKKLSEAKTQGNREFMAEMETLGK 967 Query: 349 IHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAE---KSFSWDKLNEIALGIARG 519 + H N+V L+G+CS + LVYEYM NGS+D ++ + + W K +IA+G ARG Sbjct: 968 VKHPNLVSLLGYCSFSEEKLLVYEYMVNGSLDHWLRNQTGMLEVLDWSKRLKIAVGAARG 1027 Query: 520 INYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 + +LH G I+H DIK NILLD +F PKVADFGLA+L Sbjct: 1028 LAFLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLARL 1067
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 137 bits (345), Expect = 3e-32 Identities = 68/159 (42%), Positives = 106/159 (66%), Gaps = 4/159 (2%) Frame = +1 Query: 178 IIAITRHFR--DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRI 351 ++ T +F +KLGQGG+G VYKG LL G +AVK L + S ++F++EV+ I R+ Sbjct: 521 VVKATENFSSCNKLGQGGFGIVYKGRLLDGK-EIAVKRLSKTSVQGTDEFMNEVTLIARL 579 Query: 352 HHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEK--SFSWDKLNEIALGIARGIN 525 H+N+V ++G C E + L+YEY+ N S+D Y+F + +W++ +I G+ARG+ Sbjct: 580 QHINLVQVLGCCIEGDEKMLIYEYLENLSLDSYLFGKTRRSKLNWNERFDITNGVARGLL 639 Query: 526 YLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 YLHQ +I+H D+K NILLD N IPK++DFG+A+++ Sbjct: 640 YLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFGMARIF 678
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 133 bits (334), Expect = 5e-31 Identities = 66/162 (40%), Positives = 105/162 (64%), Gaps = 2/162 (1%) Frame = +1 Query: 163 YAYTDIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTI 342 + Y++++ IT +F +G+GG+G VY GV+ VAVK+L E S ++F +EV + Sbjct: 564 FKYSEVVNITNNFERVIGKGGFGKVYHGVI--NGEQVAVKVLSEESAQGYKEFRAEVDLL 621 Query: 343 GRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSF--SWDKLNEIALGIAR 516 R+HH N+ LVG+C+E L+YEYM N ++ Y+ + ++SF SW++ +I+L A+ Sbjct: 622 MRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYL-AGKRSFILSWEERLKISLDAAQ 680 Query: 517 GINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 G+ YLH GC I+H D+KP NILL+ K+ADFGL++ + Sbjct: 681 GLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLSRSF 722
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 125 bits (314), Expect = 1e-28 Identities = 65/164 (39%), Positives = 100/164 (60%), Gaps = 5/164 (3%) Frame = +1 Query: 163 YAYTDIIAITRHFRDK--LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVS 336 + + ++ T +FR LG+GG+G V+KG + D VA+K L+ N +F+ EV Sbjct: 91 FTFQELAEATGNFRSDCFLGEGGFGKVFKGTIEKLDQVVAIKQLDRNGVQGIREFVVEVL 150 Query: 337 TIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIF---SAEKSFSWDKLNEIALG 507 T+ H N+V L+GFC+E +R LVYEYMP GS++ ++ S +K W+ +IA G Sbjct: 151 TLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHVLPSGKKPLDWNTRMKIAAG 210 Query: 508 IARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 ARG+ YLH +++ D+K NILL ++ PK++DFGLAK+ Sbjct: 211 AARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKV 254
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 125 bits (313), Expect = 1e-28 Identities = 64/164 (39%), Positives = 101/164 (61%), Gaps = 5/164 (3%) Frame = +1 Query: 163 YAYTDIIAITRHFRDK--LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVS 336 +A+ ++ A T +F LG+GG+G VYKG L VAVK L+ N +F+ EV Sbjct: 74 FAFRELAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGNREFLVEVL 133 Query: 337 TIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSA---EKSFSWDKLNEIALG 507 + +HH N+V L+G+C++ +R LVYE+MP GS++ ++ +++ W+ +IA G Sbjct: 134 MLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIAAG 193 Query: 508 IARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 A+G+ +LH + +++ D K NILLD F PK++DFGLAKL Sbjct: 194 AAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKL 237
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 122 bits (307), Expect = 7e-28 Identities = 70/163 (42%), Positives = 91/163 (55%), Gaps = 5/163 (3%) Frame = +1 Query: 166 AYTDIIAITRHFRDK--LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVST 339 +Y D++ T F +G GG+G VYK L P VA+K L + +F +EV T Sbjct: 723 SYDDLLDSTNSFDQANIIGCGGFGMVYKATL-PDGKKVAIKKLSGDCGQIEREFEAEVET 781 Query: 340 IGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKS---FSWDKLNEIALGI 510 + R H N+V L GFC + R L+Y YM NGS+D ++ W IA G Sbjct: 782 LSRAQHPNLVLLRGFCFYKNDRLLIYSYMENGSLDYWLHERNDGPALLKWKTRLRIAQGA 841 Query: 511 ARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 A+G+ YLH+GCD ILH DIK NILLD NF +ADFGLA+L Sbjct: 842 AKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLADFGLARL 884
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 122 bits (307), Expect = 7e-28 Identities = 74/196 (37%), Positives = 109/196 (55%), Gaps = 9/196 (4%) Frame = +1 Query: 79 AYKYWKTR----IIIDAVEKFLRIQQLIGPTRYAYTDIIAITRHFRDK--LGQGGYGTVY 240 A+K+ R I + A EK LR + + D++ T F + +G GG+G VY Sbjct: 852 AWKFTSAREALSINLAAFEKPLR--------KLTFADLLEATNGFHNDSLVGSGGFGDVY 903 Query: 241 KGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFCSEEMRRALVYE 420 K L G V VA+K L S +F +E+ TIG+I H N+V L+G+C R LVYE Sbjct: 904 KAQLKDGSV-VAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYE 962 Query: 421 YMPNGSMDKYIFSAEKS---FSWDKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILL 591 YM GS++ + +K+ +W +IA+G ARG+ +LH C I+H D+K N+LL Sbjct: 963 YMKYGSLEDVLHDRKKTGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLL 1022 Query: 592 DSNFIPKVADFGLAKL 639 D N +V+DFG+A+L Sbjct: 1023 DENLEARVSDFGMARL 1038
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 122 bits (307), Expect = 7e-28 Identities = 63/165 (38%), Positives = 98/165 (59%), Gaps = 5/165 (3%) Frame = +1 Query: 160 RYAYTDIIAITRHFRDK--LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEV 333 + + D++ T F + +G GG+G VYK +L G VA+K L S +F++E+ Sbjct: 870 KLTFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSA-VAIKKLIHVSGQGDREFMAEM 928 Query: 334 STIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKS---FSWDKLNEIAL 504 TIG+I H N+V L+G+C R LVYE+M GS++ + +K+ +W +IA+ Sbjct: 929 ETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAI 988 Query: 505 GIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 G ARG+ +LH C I+H D+K N+LLD N +V+DFG+A+L Sbjct: 989 GSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARL 1033
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 122 bits (306), Expect = 9e-28 Identities = 68/170 (40%), Positives = 101/170 (59%), Gaps = 11/170 (6%) Frame = +1 Query: 163 YAYTDIIAITRHFR--DKLGQGGYGTVYKG-----VLLPGDVH----VAVKMLEENSNCN 309 Y + D+ T++F+ LGQGG+G VY+G L P V VA+K L S Sbjct: 74 YNFLDLKTATKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIKRLNSESVQG 133 Query: 310 GEDFISEVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKL 489 ++ SEV+ +G + H N+V L+G+C E+ LVYE+MP GS++ ++F F WD Sbjct: 134 FAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRRNDPFPWDLR 193 Query: 490 NEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 +I +G ARG+ +LH ++++ D K NILLDSN+ K++DFGLAKL Sbjct: 194 IKIVIGAARGLAFLH-SLQREVIYRDFKASNILLDSNYDAKLSDFGLAKL 242
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 122 bits (306), Expect = 9e-28 Identities = 74/196 (37%), Positives = 108/196 (55%), Gaps = 9/196 (4%) Frame = +1 Query: 79 AYKYWKTR----IIIDAVEKFLRIQQLIGPTRYAYTDIIAITRHFRDK--LGQGGYGTVY 240 A+K+ R I + A EK LR + + D++ T F + +G GG+G VY Sbjct: 852 AWKFTSAREALSINLAAFEKPLR--------KLTFADLLEATNGFHNDSLVGSGGFGDVY 903 Query: 241 KGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFCSEEMRRALVYE 420 K L G V VA+K L S +F +E+ TIG+I H N+V L+G+C R LVYE Sbjct: 904 KAQLKDGSV-VAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYE 962 Query: 421 YMPNGSMDKYIFSAEK---SFSWDKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILL 591 YM GS++ + +K +W +IA+G ARG+ +LH C I+H D+K N+LL Sbjct: 963 YMKYGSLEDVLHDRKKIGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLL 1022 Query: 592 DSNFIPKVADFGLAKL 639 D N +V+DFG+A+L Sbjct: 1023 DENLEARVSDFGMARL 1038
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 120 bits (302), Expect = 3e-27 Identities = 61/147 (41%), Positives = 90/147 (61%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFCS 390 +G GG+G VYK L G V VA+K L + + +F++E+ TIG+I H N+V L+G+C Sbjct: 864 IGSGGFGDVYKAKLADGSV-VAIKKLIQVTGQGDREFMAEMETIGKIKHRNLVPLLGYCK 922 Query: 391 EEMRRALVYEYMPNGSMDKYIFSAEKS----FSWDKLNEIALGIARGINYLHQGCDMQIL 558 R LVYEYM GS++ + K W +IA+G ARG+ +LH C I+ Sbjct: 923 IGEERLLVYEYMKYGSLETVLHEKTKKGGIFLDWSARKKIAIGAARGLAFLHHSCIPHII 982 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+K N+LLD +F+ +V+DFG+A+L Sbjct: 983 HRDMKSSNVLLDQDFVARVSDFGMARL 1009
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 120 bits (302), Expect = 3e-27 Identities = 74/166 (44%), Positives = 95/166 (57%), Gaps = 6/166 (3%) Frame = +1 Query: 160 RYAYTDIIAITRHFRDK--LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGE-DFISE 330 R++ ++ + +F +K LG+GG+G VYKG L G + VAVK L+E GE F +E Sbjct: 276 RFSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTL-VAVKRLKEERTQGGELQFQTE 334 Query: 331 VSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKS---FSWDKLNEIA 501 V I H N++ L GFC R LVY YM NGS+ + +S W K IA Sbjct: 335 VEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIA 394 Query: 502 LGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 LG ARG+ YLH CD +I+H D+K NILLD F V DFGLAKL Sbjct: 395 LGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKL 440
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 119 bits (299), Expect = 6e-27 Identities = 66/160 (41%), Positives = 90/160 (56%), Gaps = 5/160 (3%) Frame = +1 Query: 175 DIIAITRHFRDK--LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGR 348 DI+ T F +G GG+G VYK L P VA+K L ++ +F +EV T+ R Sbjct: 735 DILKSTSSFNQANIIGCGGFGLVYKATL-PDGTKVAIKRLSGDTGQMDREFQAEVETLSR 793 Query: 349 IHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFS---AEKSFSWDKLNEIALGIARG 519 H N+V L+G+C+ + + L+Y YM NGS+D ++ S W IA G A G Sbjct: 794 AQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLHEKVDGPPSLDWKTRLRIARGAAEG 853 Query: 520 INYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 + YLHQ C+ ILH DIK NILL F+ +ADFGLA+L Sbjct: 854 LAYLHQSCEPHILHRDIKSSNILLSDTFVAHLADFGLARL 893
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 118 bits (295), Expect = 2e-26 Identities = 65/172 (37%), Positives = 107/172 (62%), Gaps = 14/172 (8%) Frame = +1 Query: 163 YAYTDIIAITRHFRDK--LGQGGYGTVYKGVL--------LPGD-VHVAVKMLEENSNCN 309 + + ++ A TR+FR LG+GG+G+V+KG + PG V +AVK L ++ Sbjct: 57 FTFAELKAATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPGTGVVIAVKKLNQDGWQG 116 Query: 310 GEDFISEVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSF---SW 480 +++++EV+ +G+ H N+V L+G+C E+ R LVYE+MP GS++ ++F F SW Sbjct: 117 HQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGSYFQPLSW 176 Query: 481 DKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 ++ALG A+G+ +LH + +++ D K NILLDS + K++DFGLAK Sbjct: 177 TLRLKVALGAAKGLAFLH-NAETSVIYRDFKTSNILLDSEYNAKLSDFGLAK 227
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 118 bits (295), Expect = 2e-26 Identities = 72/217 (33%), Positives = 108/217 (49%), Gaps = 4/217 (1%) Frame = +1 Query: 1 AAIAILKFLFVLCRFLLAPLAVWIFLAYKYWKTRIIIDAVEKFLRIQQLIGPTRYAYTDI 180 A I + LF++C FL + ++FL K I I A E + + Sbjct: 763 AMIVLGALLFIICLFLFS---AFLFLHCKKSVQEIAISAQEGDGSL----------LNKV 809 Query: 181 IAITRHFRDK--LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIH 354 + T + DK +G+G +GT+YK L P V+ K++ + E+ TIG++ Sbjct: 810 LEATENLNDKYVIGKGAHGTIYKATLSPDKVYAVKKLVFTGIKNGSVSMVREIETIGKVR 869 Query: 355 HVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAE--KSFSWDKLNEIALGIARGINY 528 H N++ L F + ++Y YM NGS+ + K W + IA+G A G+ Y Sbjct: 870 HRNLIKLEEFWLRKEYGLILYTYMENGSLHDILHETNPPKPLDWSTRHNIAVGTAHGLAY 929 Query: 529 LHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 LH CD I+H DIKP NILLDS+ P ++DFG+AKL Sbjct: 930 LHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIAKL 966
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 115 bits (289), Expect = 8e-26 Identities = 61/144 (42%), Positives = 92/144 (63%), Gaps = 2/144 (1%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLE-ENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 +G+GG G VY+G + P +V VA+K L + + F +E+ T+GRI H +IV L+G+ Sbjct: 698 IGKGGAGIVYRGSM-PNNVDVAIKRLVGRGTGRSDHGFTAEIQTLGRIRHRHIVRLLGYV 756 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKS-FSWDKLNEIALGIARGINYLHQGCDMQILHF 564 + + L+YEYMPNGS+ + + ++ W+ + +A+ A+G+ YLH C ILH Sbjct: 757 ANKDTNLLLYEYMPNGSLGELLHGSKGGHLQWETRHRVAVEAAKGLCYLHHDCSPLILHR 816 Query: 565 DIKPHNILLDSNFIPKVADFGLAK 636 D+K +NILLDS+F VADFGLAK Sbjct: 817 DVKSNNILLDSDFEAHVADFGLAK 840
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 114 bits (286), Expect = 2e-25 Identities = 62/148 (41%), Positives = 92/148 (62%), Gaps = 5/148 (3%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFCS 390 +G GG+G VYK L G V VA+K L + +F++E+ TIG+I H N+V L+G+C Sbjct: 865 VGSGGFGEVYKAQLRDGSV-VAIKKLIRITGQGDREFMAEMETIGKIKHRNLVPLLGYCK 923 Query: 391 EEMRRALVYEYMPNGSMDKYIF--SAEKS---FSWDKLNEIALGIARGINYLHQGCDMQI 555 R LVYEYM GS++ + S++K +W +IA+G ARG+ +LH C I Sbjct: 924 VGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPHI 983 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAKL 639 +H D+K N+LLD +F +V+DFG+A+L Sbjct: 984 IHRDMKSSNVLLDEDFEARVSDFGMARL 1011
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 113 bits (283), Expect = 4e-25 Identities = 62/172 (36%), Positives = 107/172 (62%), Gaps = 14/172 (8%) Frame = +1 Query: 163 YAYTDIIAITRHFRDK--LGQGGYGTVYKGVL--------LPGD-VHVAVKMLEENSNCN 309 ++ +++ + TR+FR +G+GG+G V+KG + PG + +AVK L + Sbjct: 56 FSLSELKSATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRLNQEGFQG 115 Query: 310 GEDFISEVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIF---SAEKSFSW 480 ++++E++ +G++ H N+V L+G+C EE R LVYE+M GS++ ++F + + SW Sbjct: 116 HREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFRRGTFYQPLSW 175 Query: 481 DKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +ALG ARG+ +LH Q+++ D K NILLDSN+ K++DFGLA+ Sbjct: 176 NTRVRMALGAARGLAFLH-NAQPQVIYRDFKASNILLDSNYNAKLSDFGLAR 226
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 112 bits (281), Expect = 7e-25 Identities = 62/172 (36%), Positives = 108/172 (62%), Gaps = 14/172 (8%) Frame = +1 Query: 163 YAYTDIIAITRHFRDK--LGQGGYGTVYKGVL--------LPGD-VHVAVKMLEENSNCN 309 +++ ++ + TR+FR LG+GG+G V+KG + PG + +AVK L ++ Sbjct: 56 FSFAELKSATRNFRPDSVLGEGGFGCVFKGWIDEKSLTASRPGTGLVIAVKKLNQDGWQG 115 Query: 310 GEDFISEVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSF---SW 480 +++++EV+ +G+ H ++V L+G+C E+ R LVYE+MP GS++ ++F F SW Sbjct: 116 HQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGLYFQPLSW 175 Query: 481 DKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 ++ALG A+G+ +LH + ++++ D K NILLDS + K++DFGLAK Sbjct: 176 KLRLKVALGAAKGLAFLHSS-ETRVIYRDFKTSNILLDSEYNAKLSDFGLAK 226
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 112 bits (280), Expect = 9e-25 Identities = 60/152 (39%), Positives = 89/152 (58%), Gaps = 3/152 (1%) Frame = +1 Query: 190 TRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIV 369 T ++ +G+GG+G+VY+G L G VAVK+ S +F +E++ + I H N+V Sbjct: 595 TEQYKTLIGEGGFGSVYRGTLDDGQ-EVAVKVRSSTSTQGTREFDNELNLLSAIQHENLV 653 Query: 370 CLVGFCSEEMRRALVYEYMPNGSMDKYIF---SAEKSFSWDKLNEIALGIARGINYLHQG 540 L+G+C+E ++ LVY +M NGS+ ++ S K W IALG ARG+ YLH Sbjct: 654 PLLGYCNEYDQQILVYPFMSNGSLLDRLYGEASKRKILDWPTRLSIALGAARGLAYLHTF 713 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 ++H D+K NILLD + KVADFG +K Sbjct: 714 PGRSVIHRDVKSSNILLDQSMCAKVADFGFSK 745
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 110 bits (274), Expect = 5e-24 Identities = 59/152 (38%), Positives = 89/152 (58%), Gaps = 3/152 (1%) Frame = +1 Query: 190 TRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIV 369 T ++ +G+GG+G+VY+G L G VAVK+ S +F +E++ + I H N+V Sbjct: 594 TEKYKTLIGEGGFGSVYRGTLDDGQ-EVAVKVRSATSTQGTREFDNELNLLSAIQHENLV 652 Query: 370 CLVGFCSEEMRRALVYEYMPNGSMDKYIF---SAEKSFSWDKLNEIALGIARGINYLHQG 540 L+G+C+E ++ LVY +M NGS+ ++ + K W IALG ARG+ YLH Sbjct: 653 PLLGYCNEYDQQILVYPFMSNGSLLDRLYGEPAKRKILDWPTRLSIALGAARGLAYLHTF 712 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 ++H D+K NILLD + KVADFG +K Sbjct: 713 PGRSVIHRDVKSSNILLDHSMCAKVADFGFSK 744
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 110 bits (274), Expect = 5e-24 Identities = 60/160 (37%), Positives = 92/160 (57%), Gaps = 8/160 (5%) Frame = +1 Query: 184 AITRHFRDK--LGQGGYGTVYKGVLLPGDVHVAVKMLEEN--SNCNGEDFISEVSTIGRI 351 ++T +F LG GG+G VYKG L G +AVK +E + +F SE++ + ++ Sbjct: 583 SVTNNFSSDNILGSGGFGVVYKGELHDG-TKIAVKRMENGVIAGKGFAEFKSEIAVLTKV 641 Query: 352 HHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAE----KSFSWDKLNEIALGIARG 519 H ++V L+G+C + + LVYEYMP G++ +++F K W + +AL +ARG Sbjct: 642 RHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLLWKQRLTLALDVARG 701 Query: 520 INYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 + YLH +H D+KP NILL + KVADFGL +L Sbjct: 702 VEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRL 741
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 108 bits (269), Expect = 2e-23 Identities = 58/164 (35%), Positives = 94/164 (57%), Gaps = 7/164 (4%) Frame = +1 Query: 169 YTDIIAITRHFR--DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTI 342 ++ +I T F +G GG+G V+K L G VA+K L S +F++E+ T+ Sbjct: 828 FSQLIEATNGFSAASMIGHGGFGEVFKATLKDGS-SVAIKKLIRLSCQGDREFMAEMETL 886 Query: 343 GRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAE-----KSFSWDKLNEIALG 507 G+I H N+V L+G+C R LVYE+M GS+++ + + W++ +IA G Sbjct: 887 GKIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAKG 946 Query: 508 IARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 A+G+ +LH C I+H D+K N+LLD + +V+DFG+A+L Sbjct: 947 AAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGMARL 990
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 104 bits (260), Expect = 2e-22 Identities = 62/170 (36%), Positives = 96/170 (56%), Gaps = 9/170 (5%) Frame = +1 Query: 154 PTRYAYTDIIAITRHFRDKL--GQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG----E 315 P + + +I T +F ++L G+GG+G VY+ V+ + AVK L+E ++ + Sbjct: 197 PFCWPFCEISQGTCNFSEELRIGEGGFGCVYRAVMR--NTTYAVKRLKEEADLEWTMVKQ 254 Query: 316 DFISEVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIF---SAEKSFSWDK 486 F++EV + R H NIV G+C+E LVY ++PNGS++ + A SW + Sbjct: 255 SFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQ 314 Query: 487 LNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 +I LG AR I +LHQ ++H DIK N+LLD +PK+ DFGLA+ Sbjct: 315 RLDILLGTARAIQFLHQD-SPSLIHGDIKSSNVLLDERLMPKLGDFGLAR 363
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 104 bits (260), Expect = 2e-22 Identities = 66/159 (41%), Positives = 89/159 (55%), Gaps = 13/159 (8%) Frame = +1 Query: 202 RDKLGQGGYGTVYKGVLLPGDVHVAVKMLEEN----------SNCNGEDFISEVSTIGRI 351 ++ +G G G VYK L G+V VAVK L ++ + N + F +EV T+G I Sbjct: 686 KNVIGFGSSGKVYKVELRGGEV-VAVKKLNKSVKGGDDEYSSDSLNRDVFAAEVETLGTI 744 Query: 352 HHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKS---FSWDKLNEIALGIARGI 522 H +IV L CS + LVYEYMPNGS+ + K W + IAL A G+ Sbjct: 745 RHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKGGVVLGWPERLRIALDAAEGL 804 Query: 523 NYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 +YLH C I+H D+K NILLDS++ KVADFG+AK+ Sbjct: 805 SYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIAKV 843
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 104 bits (259), Expect = 3e-22 Identities = 57/150 (38%), Positives = 88/150 (58%), Gaps = 7/150 (4%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG----EDFISEVSTIGRIHHVNIVCL 375 K+G+GG+G VY+ V+ + AVK L+EN++ + F++EV + R H NIV Sbjct: 217 KIGEGGFGCVYRAVMR--NTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 274 Query: 376 VGFCSEEMRRALVYEYMPNGSMDKYIFSAEKS---FSWDKLNEIALGIARGINYLHQGCD 546 G+C++ LVY ++PNGS++ + ++ SW + +I LG AR I +LHQ Sbjct: 275 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQD-S 333 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAK 636 ++H DIK N+LLD PK+ DFGLA+ Sbjct: 334 PSLIHGDIKSSNVLLDERLTPKLGDFGLAR 363
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 100 bits (250), Expect = 3e-21 Identities = 63/195 (32%), Positives = 112/195 (57%), Gaps = 8/195 (4%) Frame = +1 Query: 79 AYKYWKTRIIIDAVEKFLRIQQLIGPTRYAYTDIIAITRHFRD--KLGQGGYGTVYKGVL 252 AY + K + I + L+I++ ++Y ++ T F + ++G+G + V+KG+L Sbjct: 468 AYSFRKDNMKIQPDMEDLKIRRA---QEFSYEELEQATGGFSEDSQVGKGSFSCVFKGIL 524 Query: 253 LPGDVHVAVKMLEENSNC--NGEDFISEVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYM 426 G V VAVK + S+ + ++F +E+ + R++H +++ L+G+C + R LVYE+M Sbjct: 525 RDGTV-VAVKRAIKASDVKKSSKEFHNELDLLSRLNHAHLLNLLGYCEDGSERLLVYEFM 583 Query: 427 PNGSMDKYIFSAE----KSFSWDKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLD 594 +GS+ +++ + K +W + IA+ ARGI YLH ++H DIK NIL+D Sbjct: 584 AHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILID 643 Query: 595 SNFIPKVADFGLAKL 639 + +VADFGL+ L Sbjct: 644 EDHNARVADFGLSIL 658
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 97.1 bits (240), Expect = 4e-20 Identities = 61/150 (40%), Positives = 84/150 (56%), Gaps = 6/150 (4%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGED----FISEVSTIGRIHHVNIVC 372 +K+G+GG+G VYKG + + VAVK L + E+ F E+ + + H N+V Sbjct: 190 NKMGEGGFGVVYKGYV--NNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVE 247 Query: 373 LVGFCSEEMRRALVYEYMPNGS-MDKY-IFSAEKSFSWDKLNEIALGIARGINYLHQGCD 546 L+GF S+ LVY YMPNGS +D+ SW +IA G A GIN+LH+ Sbjct: 248 LLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN-- 305 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAK 636 +H DIK NILLD F K++DFGLA+ Sbjct: 306 -HHIHRDIKSANILLDEAFTAKISDFGLAR 334
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 96.3 bits (238), Expect = 7e-20 Identities = 61/172 (35%), Positives = 95/172 (55%), Gaps = 14/172 (8%) Frame = +1 Query: 163 YAYTDIIAITRHFRD--------KLGQGGYGTVYKGVLLPGDVHVAVK----MLEENSNC 306 +++ ++ +IT +F + ++G+GG+G VYKG + + VAVK M+E ++ Sbjct: 168 FSFHELKSITNNFDEQPASAGGNRMGEGGFGVVYKGCV--NNTIVAVKKLGAMVEISTEE 225 Query: 307 NGEDFISEVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGS-MDKY-IFSAEKSFSW 480 + F E+ + H N+V L+GF S+ LVY YMPNGS +D+ SW Sbjct: 226 LKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTPPLSW 285 Query: 481 DKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 ++A G A GI +LH+ +H DIK NILLD +F K++DFGLA+ Sbjct: 286 HTRCKVAQGTANGIRFLHEN---HHIHRDIKSANILLDKDFTAKISDFGLAR 334
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 92.4 bits (228), Expect = 1e-18 Identities = 54/146 (36%), Positives = 88/146 (60%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G VYKG L LPG +++VA+K L+ S DF+SE S +G+ H NI+ L Sbjct: 625 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLE 684 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M NG++D ++ + F+ +L + GIA G+ YL +M + Sbjct: 685 GVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL---AEMNYV 741 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 742 HRDLAARNILVNSNLVCKVSDFGLSR 767
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 92.4 bits (228), Expect = 1e-18 Identities = 54/146 (36%), Positives = 88/146 (60%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G VYKG L LPG +++VA+K L+ S DF+SE S +G+ H NI+ L Sbjct: 625 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLE 684 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M NG++D ++ + F+ +L + GIA G+ YL +M + Sbjct: 685 GVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL---AEMNYV 741 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 742 HRDLAARNILVNSNLVCKVSDFGLSR 767
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 92.0 bits (227), Expect = 1e-18 Identities = 54/146 (36%), Positives = 88/146 (60%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G VYKG L LPG +++VA+K L+ S DF+SE S +G+ H NI+ L Sbjct: 625 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLE 684 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M NG++D ++ + F+ +L + GIA G+ YL +M + Sbjct: 685 GVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL---SEMNYV 741 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 742 HRDLAARNILVNSNLVCKVSDFGLSR 767
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 92.0 bits (227), Expect = 1e-18 Identities = 52/159 (32%), Positives = 92/159 (57%), Gaps = 4/159 (2%) Frame = +1 Query: 175 DIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIH 354 D++ T +K YGTVYK L G ++A+++L E + + + + +GRI Sbjct: 370 DVLNATGQVMEKTS---YGTVYKAKLSDGG-NIALRLLREGTCKDRSSCLPVIRQLGRIR 425 Query: 355 HVNIVCLVGFCSEEM-RRALVYEYMPNGSMDKYIFSAEK---SFSWDKLNEIALGIARGI 522 H N+V L F + + L+Y+Y+PN S+ + ++ + +W + ++IALGIARG+ Sbjct: 426 HENLVPLRAFYQGKRGEKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKIALGIARGL 485 Query: 523 NYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 YLH G ++ I+H +I+ N+L+D F ++ +FGL K+ Sbjct: 486 AYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGLDKI 524
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 91.7 bits (226), Expect = 2e-18 Identities = 54/148 (36%), Positives = 86/148 (58%), Gaps = 5/148 (3%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPG----DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCL 375 +G G +G VYKG L ++ VA+K L+ + DF+SE S +G+ H NI+ L Sbjct: 620 IGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIPL 679 Query: 376 VGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQI 555 G S+ ++ EYM NG++DK++ + FS +L + GIA G+ YL +M Sbjct: 680 EGVVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIASGMKYL---ANMNY 736 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAKL 639 +H D+ NIL++SN + KV+DFGL+++ Sbjct: 737 VHRDLAARNILVNSNLVCKVSDFGLSRV 764
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 89.4 bits (220), Expect = 8e-18 Identities = 52/154 (33%), Positives = 88/154 (57%), Gaps = 8/154 (5%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNGE-DFISEVSTIGRIHHVNI 366 F ++LG+G +G VYKG LL + + VA+K L+EN++ + DF E+ I + H NI Sbjct: 412 FLEELGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNI 471 Query: 367 VCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAE----KSFSWDKLNEIALGIARGINYLH 534 VC++G + +++EYM NG + +++ S KS S + +IAL I+ G+ YL Sbjct: 472 VCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQIALQISEGMQYLS 531 Query: 535 QGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 +H D+ N L++ + K++DFGL++ Sbjct: 532 A---HHYVHRDLAARNCLVNEGLVVKISDFGLSR 562
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 89.4 bits (220), Expect = 8e-18 Identities = 53/148 (35%), Positives = 85/148 (57%), Gaps = 5/148 (3%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPG----DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCL 375 +G G +G VYKG+L +V VA+K L+ + DF+ E +G+ H NI+ L Sbjct: 619 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRL 678 Query: 376 VGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQI 555 G S+ ++ EYM NG++DK++ + FS +L + GIA G+ YL +M Sbjct: 679 EGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYL---ANMNY 735 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAKL 639 +H D+ NIL++SN + KV+DFGL+++ Sbjct: 736 VHRDLAARNILVNSNLVCKVSDFGLSRV 763
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 88.6 bits (218), Expect = 1e-17 Identities = 53/146 (36%), Positives = 86/146 (58%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G VYKG L LP ++ VA+K L+ S DF+SE S +G+ H NI+ L Sbjct: 543 IGAGEFGEVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLE 602 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M NG++D ++ + F+ +L + GIA G+ YL +M + Sbjct: 603 GVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL---SEMNYV 659 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 660 HRDLAARNILVNSNLVCKVSDFGLSR 685
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 88.6 bits (218), Expect = 1e-17 Identities = 53/146 (36%), Positives = 86/146 (58%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G VYKG L LP ++ VA+K L+ S DF+SE S +G+ H NI+ L Sbjct: 626 IGAGEFGEVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLE 685 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M NG++D ++ + F+ +L + GIA G+ YL +M + Sbjct: 686 GVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL---SEMNYV 742 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 743 HRDLAARNILVNSNLVCKVSDFGLSR 768
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 88.2 bits (217), Expect = 2e-17 Identities = 55/159 (34%), Positives = 83/159 (52%), Gaps = 15/159 (9%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAV----------KMLEENSNCNGEDFISEVSTIGRIH 354 ++LGQGG+G VY+G DV + V KM+E + N E+ + I Sbjct: 217 NRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYN------ELKYLNSIR 270 Query: 355 HVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEK-----SFSWDKLNEIALGIARG 519 H NI+ L G+ + + LVY+ M GS++ + + + + +W + I+LG ARG Sbjct: 271 HDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARG 330 Query: 520 INYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 I +LH ++H DIKP NILLD PK+ DFGL + Sbjct: 331 IYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVR 369
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 87.4 bits (215), Expect = 3e-17 Identities = 52/146 (35%), Positives = 85/146 (58%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LPG ++ VA+K L+ + DF+SE S +G+ H N++ L Sbjct: 627 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLE 686 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M NGS+D ++ + F+ +L + GIA G+ YL DM + Sbjct: 687 GVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL---ADMNYV 743 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 744 HRDLAARNILVNSNLVCKVSDFGLSR 769
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 87.4 bits (215), Expect = 3e-17 Identities = 52/146 (35%), Positives = 85/146 (58%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LPG ++ VA+K L+ + DF+SE S +G+ H N++ L Sbjct: 645 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLE 704 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M NGS+D ++ + F+ +L + GIA G+ YL DM + Sbjct: 705 GVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL---ADMNYV 761 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 762 HRDLAARNILVNSNLVCKVSDFGLSR 787
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 87.4 bits (215), Expect = 3e-17 Identities = 52/146 (35%), Positives = 85/146 (58%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LPG ++ VA+K L+ + DF+SE S +G+ H N++ L Sbjct: 635 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLE 694 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M NGS+D ++ + F+ +L + GIA G+ YL DM + Sbjct: 695 GVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL---ADMNYV 751 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 752 HRDLAARNILVNSNLVCKVSDFGLSR 777
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 87.0 bits (214), Expect = 4e-17 Identities = 56/159 (35%), Positives = 88/159 (55%), Gaps = 4/159 (2%) Frame = +1 Query: 175 DIIAITRHFRDKLGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTI 342 +I A H +G G G V G L +PG DV VA+K L+ + DF+SE S + Sbjct: 629 EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIM 688 Query: 343 GRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGI 522 G+ H NI+ L G + +V EYM NGS+D ++ + + F+ +L + G+ G+ Sbjct: 689 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGM 748 Query: 523 NYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 YL D+ +H D+ N+L+DSN + KV+DFGL+++ Sbjct: 749 RYL---SDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRV 784
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 86.3 bits (212), Expect = 7e-17 Identities = 54/147 (36%), Positives = 85/147 (57%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LPG ++ VA+K L+ + DF+ E S +G+ H NI+ L Sbjct: 520 IGAGEFGEVCSGCLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLE 579 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ +V EYM NGS+D ++ + F+ +L + GIA G+ YL DM + Sbjct: 580 GVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYL---SDMGYV 636 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFGL+++ Sbjct: 637 HRDLAARNILINSNLVCKVSDFGLSRV 663
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 85.9 bits (211), Expect = 9e-17 Identities = 53/147 (36%), Positives = 84/147 (57%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LP ++ VA+K L+ + DF+ E S +G+ H NI+ L Sbjct: 627 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 686 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ +V EYM NGS+D ++ + F+ +L + GIA G+ YL DM + Sbjct: 687 GVVTKSKPEMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYL---SDMGYV 743 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFGL+++ Sbjct: 744 HRDLAARNILINSNLVCKVSDFGLSRV 770
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 85.9 bits (211), Expect = 9e-17 Identities = 55/147 (37%), Positives = 85/147 (57%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LPG ++ VA K L+ + DF+SE S +G+ H NI+ L Sbjct: 683 IGAGEFGEVCSGRLKLPGKRELPVATKTLKVGYTEKQRRDFLSEASIMGQFDHPNIIHLE 742 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ +V EYM NGS+D ++ + F+ +L + GIA G+ YL DM + Sbjct: 743 GVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYL---SDMGYV 799 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFGL+++ Sbjct: 800 HRDLAARNILINSNLVCKVSDFGLSRV 826
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 85.9 bits (211), Expect = 9e-17 Identities = 55/147 (37%), Positives = 84/147 (57%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LPG DV VA+K L+ + DF+ E S +G+ H N+V L Sbjct: 634 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 693 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G + +V EYM NG++D ++ + F+ +L + GIA G+ YL DM + Sbjct: 694 GVVTRGKPVMIVIEYMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYL---ADMGYV 750 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFGL+++ Sbjct: 751 HRDLAARNILVNSNLVCKVSDFGLSRV 777
>EPA4A_XENLA (Q91845) Ephrin type-A receptor 4-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK-1) (xSEK-1) Length = 986 Score = 85.5 bits (210), Expect = 1e-16 Identities = 52/147 (35%), Positives = 87/147 (59%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L +PG +++VA+K L+ ++ DF+SE S +G+ H NI+ L Sbjct: 626 IGVGEFGEVCSGRLKVPGKREIYVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLE 685 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ EYM NGS+D ++ + F+ +L I GI G+ YL DM + Sbjct: 686 GVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGILRGIGSGMKYL---SDMSYV 742 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFG++++ Sbjct: 743 HRDLAARNILVNSNLVCKVSDFGMSRV 769
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 85.5 bits (210), Expect = 1e-16 Identities = 51/146 (34%), Positives = 84/146 (57%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LPG ++ VA+K L+ + DF+SE S +G+ H N++ L Sbjct: 628 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLE 687 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M NGS+D ++ + F+ +L + GIA G+ YL DM + Sbjct: 688 GVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL---ADMNYV 744 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ N L++SN + KV+DFGL++ Sbjct: 745 HRDLAARNTLVNSNLVCKVSDFGLSR 770
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 85.1 bits (209), Expect = 2e-16 Identities = 53/147 (36%), Positives = 87/147 (59%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L +PG ++ VA+K L+ ++ DF+SE S +G+ H NI+ L Sbjct: 1 IGIGEFGEVCSGRLKMPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIRLE 60 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ EYM NGS+D ++ + F+ +L I GIA G+ YL DM + Sbjct: 61 GVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGILRGIASGMKYL---SDMSYV 117 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFG++++ Sbjct: 118 HRDLAARNILVNSNLVCKVSDFGMSRV 144
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 85.1 bits (209), Expect = 2e-16 Identities = 53/147 (36%), Positives = 84/147 (57%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LP ++ VA+K L+ + DF+ E S +G+ H NI+ L Sbjct: 627 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKAGYTEKQRRDFLGEASIMGQFDHPNIIRLE 686 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ +V EYM NGS+D ++ + F+ +L + GIA G+ YL DM + Sbjct: 687 GVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYL---SDMGYV 743 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFGL+++ Sbjct: 744 HRDLAARNILINSNLVCKVSDFGLSRV 770
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 84.7 bits (208), Expect = 2e-16 Identities = 53/147 (36%), Positives = 84/147 (57%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LP ++ VA+K L+ + DF+ E S +G+ H NI+ L Sbjct: 627 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 686 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ +V EYM NGS+D ++ + F+ +L + GIA G+ YL DM + Sbjct: 687 GVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYL---SDMGYV 743 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFGL+++ Sbjct: 744 HRDLAARNILINSNLVCKVSDFGLSRV 770
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 84.7 bits (208), Expect = 2e-16 Identities = 49/153 (32%), Positives = 89/153 (58%), Gaps = 5/153 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCL 375 + ++K+G G +GTV++ DV V + M ++ +F+ EV+ + R+ H NIV Sbjct: 552 NIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLF 611 Query: 376 VGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNE-----IALGIARGINYLHQG 540 +G ++ ++V EY+ GS+ + + KS + ++L+E +A +A+G+NYLH Sbjct: 612 MGAVTQPPNLSIVTEYLSRGSLYRLL---HKSGAREQLDERRRLSMAYDVAKGMNYLHNR 668 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 + I+H D+K N+L+D + KV DFGL++L Sbjct: 669 -NPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRL 700
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 84.7 bits (208), Expect = 2e-16 Identities = 53/147 (36%), Positives = 84/147 (57%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LP ++ VA+K L+ + DF+ E S +G+ H NI+ L Sbjct: 628 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 687 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ +V EYM NGS+D ++ + F+ +L + GIA G+ YL DM + Sbjct: 688 GVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYL---SDMGYV 744 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFGL+++ Sbjct: 745 HRDLAARNILINSNLVCKVSDFGLSRV 771
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 84.3 bits (207), Expect = 3e-16 Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LPG DV VA+K L+ + DF+ E S +G+ H N+V L Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 698 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G + +V E+M NG++D ++ + F+ +L + GIA G+ YL DM + Sbjct: 699 GVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYL---ADMGYV 755 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFGL+++ Sbjct: 756 HRDLAARNILVNSNLVCKVSDFGLSRV 782
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 84.3 bits (207), Expect = 3e-16 Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LPG DV VA+K L+ + DF+ E S +G+ H N+V L Sbjct: 639 IGAGEFGEVCSGRLKLPGQRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 698 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G + +V E+M NG++D ++ + F+ +L + GIA G+ YL DM + Sbjct: 699 GVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYL---ADMGYV 755 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFGL+++ Sbjct: 756 HRDLAARNILVNSNLVCKVSDFGLSRV 782
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 84.3 bits (207), Expect = 3e-16 Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LPG DV VA+K L+ + DF+ E S +G+ H N+V L Sbjct: 639 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 698 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G + +V E+M NG++D ++ + F+ +L + GIA G+ YL DM + Sbjct: 699 GVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYL---ADMGYV 755 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFGL+++ Sbjct: 756 HRDLAARNILVNSNLVCKVSDFGLSRV 782
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 84.3 bits (207), Expect = 3e-16 Identities = 53/147 (36%), Positives = 85/147 (57%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LPG ++ VA+K L+ + DF+ E S +G+ H NI+ L Sbjct: 681 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLE 740 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ +V EYM NGS+D ++ + F+ +L + GI+ G+ YL DM + Sbjct: 741 GVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYL---SDMGYV 797 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFGL+++ Sbjct: 798 HRDLAARNILINSNLVCKVSDFGLSRV 824
>EPA4B_XENLA (Q91694) Ephrin type-A receptor 4-B precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor PAG) (Pagliaccio) Length = 985 Score = 84.3 bits (207), Expect = 3e-16 Identities = 51/147 (34%), Positives = 87/147 (59%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L +PG +++VA+K L+ ++ DF+SE S +G+ H NI+ L Sbjct: 626 IGVGEFGEVCSGRLKVPGKREIYVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLE 685 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ EYM NGS+D ++ + F+ +L + GI G+ YL DM + Sbjct: 686 GVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYL---SDMSYV 742 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFG++++ Sbjct: 743 HRDLAARNILVNSNLVCKVSDFGMSRV 769
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 84.0 bits (206), Expect = 4e-16 Identities = 48/144 (33%), Positives = 80/144 (55%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 ++G G YG V+ G DV V + ++ S +F +E++ + + H NIV +G C Sbjct: 1369 QIGLGSYGIVFNGKWKGVDVAVKKFVKQKLSETQLLEFRAEMAFLSELKHSNIVTFIGAC 1428 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFD 567 ++ +V EYM G++ + + + ++ ++ G A GI+YLH M I+H D Sbjct: 1429 IKKPNICIVTEYMRMGNLRDVLKNPDIKITFANKLKLLYGAAMGIDYLHSSNPM-IVHRD 1487 Query: 568 IKPHNILLDSNFIPKVADFGLAKL 639 IKP NIL+D +F K+ADFG A++ Sbjct: 1488 IKPANILVDEHFNVKIADFGFARI 1511 Score = 65.9 bits (159), Expect = 1e-10 Identities = 44/146 (30%), Positives = 72/146 (49%), Gaps = 1/146 (0%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGF 384 + LG GGYG VYK + +V V + + S F EV + + H N+V + Sbjct: 790 ETLGTGGYGEVYKSIWKGTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAA 849 Query: 385 CSEEMRRALVYEYMPNGSM-DKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILH 561 ++ +V E+M GS+ D + ++A ++G+++LH I+H Sbjct: 850 STKSPNMCIVMEFMSLGSLYDLLGNELIPEIPYALKIKMAYQASKGMHFLHSS---GIVH 906 Query: 562 FDIKPHNILLDSNFIPKVADFGLAKL 639 D+K N+LLDS + KV+DFGL K+ Sbjct: 907 RDLKSLNLLLDSKWNVKVSDFGLTKV 932
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 83.6 bits (205), Expect = 5e-16 Identities = 47/146 (32%), Positives = 80/146 (54%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 F ++G G +G V+ G L D VA+K ++E + + EDFI E + ++ H +V L Sbjct: 370 FVQEIGSGQFGLVHLGYWLNKD-KVAIKTIQEGA-MSEEDFIEEAEVMMKLSHPKLVQLY 427 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G C E+ LV+E+M +G + Y+ S F+ + L + L + G+ YL + C ++ Sbjct: 428 GVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEKAC---VI 484 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ N L+ N + KV+DFG+ + Sbjct: 485 HRDLAARNCLVGENQVIKVSDFGMTR 510
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 83.6 bits (205), Expect = 5e-16 Identities = 53/146 (36%), Positives = 84/146 (57%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVLL-PG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L PG + VA+K L+ ++ +F+SE S +G+ H N++ L Sbjct: 643 IGSGEFGEVCFGRLKHPGKREYTVAIKTLKSGYTDEQRREFLSEASIMGQFEHPNVIHLE 702 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ +V E+M NGS+D ++ E FS +L + GIA G+ YL DM + Sbjct: 703 GVVTKSRPVMIVTEFMENGSLDSFLRQKEGQFSVLQLVGMLRGIAAGMRYL---SDMNYV 759 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 760 HRDLAARNILVNSNLVCKVSDFGLSR 785
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 82.8 bits (203), Expect = 8e-16 Identities = 53/147 (36%), Positives = 83/147 (56%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L LP ++ VA+K L+ S DF+SE S +G+ H NI+ L Sbjct: 632 IGAGEFGEVCSGRLRLPSKREIQVAIKSLKAGYSEHQRRDFLSEASIMGQFDHPNIIRLE 691 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G + +V EYM NGS+D ++ + F+ +L + GIA G+ YL +M + Sbjct: 692 GVVTRCKPVMIVTEYMENGSLDTFLKKHDGQFTVIQLLGMLRGIAAGMQYL---SEMNYV 748 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++ N + KV+DFGL+++ Sbjct: 749 HRDLAARNILVNRNLVCKVSDFGLSRV 775
>EPHA4_MOUSE (Q03137) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (MPK-3) Length = 986 Score = 82.4 bits (202), Expect = 1e-15 Identities = 51/147 (34%), Positives = 86/147 (58%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L +PG ++ VA+K L+ ++ DF+SE S +G+ H NI+ L Sbjct: 627 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLE 686 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ EYM NGS+D ++ + F+ +L + GI G+ YL DM + Sbjct: 687 GVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYL---SDMSYV 743 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFG++++ Sbjct: 744 HRDLAARNILVNSNLVCKVSDFGMSRV 770
>EPHA4_HUMAN (P54764) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8) Length = 986 Score = 82.4 bits (202), Expect = 1e-15 Identities = 51/147 (34%), Positives = 86/147 (58%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L +PG ++ VA+K L+ ++ DF+SE S +G+ H NI+ L Sbjct: 627 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLE 686 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ EYM NGS+D ++ + F+ +L + GI G+ YL DM + Sbjct: 687 GVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYL---SDMSYV 743 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFG++++ Sbjct: 744 HRDLAARNILVNSNLVCKVSDFGMSRV 770
>EPHA4_CHICK (Q07496) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK8) Length = 986 Score = 82.4 bits (202), Expect = 1e-15 Identities = 51/147 (34%), Positives = 86/147 (58%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L +PG ++ VA+K L+ ++ DF+SE S +G+ H NI+ L Sbjct: 627 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLE 686 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ EYM NGS+D ++ + F+ +L + GI G+ YL DM + Sbjct: 687 GVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYL---SDMSYV 743 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFG++++ Sbjct: 744 HRDLAARNILVNSNLVCKVSDFGMSRV 770
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 82.4 bits (202), Expect = 1e-15 Identities = 53/158 (33%), Positives = 86/158 (54%), Gaps = 4/158 (2%) Frame = +1 Query: 175 DIIAITRHFRDKLGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTI 342 +I A H +G G G V G L +PG DV VA+K L+ + +DF+SE + + Sbjct: 628 EIEASRIHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAIM 687 Query: 343 GRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGI 522 G+ H NI+ L G + +V EYM NGS+D ++ + + F+ +L + G+ G+ Sbjct: 688 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTIVQLVGMLRGVGAGM 747 Query: 523 NYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 YL D+ +H D+ N+L+D + KV+DFGL++ Sbjct: 748 RYL---SDLGYIHRDLAARNVLVDGRLVCKVSDFGLSR 782
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 82.0 bits (201), Expect = 1e-15 Identities = 46/146 (31%), Positives = 79/146 (54%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 F ++G G +G V+ G L D VA+K + E + + EDFI E + ++ H +V L Sbjct: 365 FVQEIGSGQFGLVHLGYWLNKD-KVAIKTIREGA-MSEEDFIEEAEVMMKLSHPKLVQLY 422 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G C E+ LV+E+M +G + Y+ + F+ + L + L + G+ YL + C ++ Sbjct: 423 GVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEAC---VI 479 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ N L+ N + KV+DFG+ + Sbjct: 480 HRDLAARNCLVGENQVIKVSDFGMTR 505
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 82.0 bits (201), Expect = 1e-15 Identities = 52/145 (35%), Positives = 84/145 (57%), Gaps = 1/145 (0%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGF 384 +KLG G YG VY+G D +AVK L+E++ E F++E + + +HH N+V L+G Sbjct: 315 NKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHE-FLAEAAIMKDLHHKNLVRLLGV 373 Query: 385 CSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWD-KLNEIALGIARGINYLHQGCDMQILH 561 C+ E ++ E+M NG++ +Y+ +KS L ++A IA G++YL +H Sbjct: 374 CTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQIASGMSYLEA---RHFIH 430 Query: 562 FDIKPHNILLDSNFIPKVADFGLAK 636 D+ N L+ + I K+ADFGLA+ Sbjct: 431 RDLAARNCLVSEHNIVKIADFGLAR 455
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 81.6 bits (200), Expect = 2e-15 Identities = 53/147 (36%), Positives = 83/147 (56%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L L G + VA+K L+ + DF+ E S +G+ H NI+ L Sbjct: 657 IGAGEFGEVCSGRLKLQGKREFPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLE 716 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ +V EYM NGS+D ++ + F+ +L + GIA G+ YL DM + Sbjct: 717 GVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIASGMKYL---SDMGYV 773 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++SN + KV+DFGL+++ Sbjct: 774 HRDLAARNILINSNLVCKVSDFGLSRV 800
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 80.9 bits (198), Expect = 3e-15 Identities = 49/146 (33%), Positives = 83/146 (56%), Gaps = 2/146 (1%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGF 384 ++LG G +G V +G G + AVKM++E + + +DFI E + ++ H N+V L G Sbjct: 530 EELGSGQFGVVRRGKWR-GSIDTAVKMMKEGT-MSEDDFIEEAKVMTKLQHPNLVQLYGV 587 Query: 385 CSEEMRRALVYEYMPNGSMDKYIFSAEKSF--SWDKLNEIALGIARGINYLHQGCDMQIL 558 CS+ +V EYM +GS+ Y+ EK+ + L ++ + +++G+ YL + + Sbjct: 588 CSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLER---HNYI 644 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ N L+ S + KVADFGLA+ Sbjct: 645 HRDLAARNCLVGSENVVKVADFGLAR 670
>CC2H1_TRYCO (P54664) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 80.9 bits (198), Expect = 3e-15 Identities = 50/151 (33%), Positives = 78/151 (51%), Gaps = 5/151 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKML-----EENSNCNGEDFISEVSTIGRIHHVNIV 369 +K+G+G YG VY+ + DV VA+K + EE C I E+S + + H NIV Sbjct: 9 EKIGEGSYGVVYRARDITTDVIVALKRIRLESVEEGVPCTA---IREISILKELRHENIV 65 Query: 370 CLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDM 549 L+ C E R LV+EYM + KY+ A + + E + +G+ + H + Sbjct: 66 RLLDVCHSENRLNLVFEYM-EMDLKKYMDRASGNLDPATIQEFMRSLLKGVRFCH---ER 121 Query: 550 QILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 +LH D+KP N+L+ K+ADFGL + + Sbjct: 122 NVLHRDLKPPNLLISREKELKLADFGLGRAF 152
>EPHB3_CHICK (Q07498) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor CEK10) (Fragment) Length = 988 Score = 80.5 bits (197), Expect = 4e-15 Identities = 50/146 (34%), Positives = 85/146 (58%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V +G L LPG ++ VA+K L+ + DF+SE S +G+ H NI+ L Sbjct: 629 IGAGEFGEVCRGRLKLPGRREIFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIHLE 688 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M N ++D ++ + F+ +L + GIA G+ YL +M + Sbjct: 689 GVVTKSRPVMIITEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYL---SEMNYV 745 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 746 HRDLAARNILVNSNLVCKVSDFGLSR 771
>EPHB3_BRARE (O13147) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK3) (EPH-like kinase 3) (Fragment) Length = 500 Score = 80.5 bits (197), Expect = 4e-15 Identities = 48/146 (32%), Positives = 81/146 (55%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPG---DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V +G L + VA+K L+ + DF+SE S +G+ H N++ L Sbjct: 193 IGAGEFGEVCRGRLKQAGRKETTVAIKTLKAGYTEHQRRDFLSEASIMGQFDHPNVIHLE 252 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G + +V E+M NG++D ++ + F+ +L + GIA G+ YL DM + Sbjct: 253 GVLTRSCPVLIVTEFMENGALDSFLRLNDGRFTVTQLVGMLRGIAAGMKYL---SDMNYV 309 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ N+L++SN + KV+DFGL++ Sbjct: 310 HRDLAARNVLVNSNLVCKVSDFGLSR 335
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 80.1 bits (196), Expect = 5e-15 Identities = 51/151 (33%), Positives = 82/151 (54%), Gaps = 4/151 (2%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVN 363 H +G G G V G L +PG DV VA+K L+ + +DF+ E + +G+ H N Sbjct: 3 HIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLREAAIMGQFDHPN 62 Query: 364 IVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGC 543 I+ L G + +V EYM NGS+D ++ + + F+ +L + G+ G+ YL Sbjct: 63 IIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTILQLVGMLKGVGAGMRYL---S 119 Query: 544 DMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 D+ +H D+ NIL+D + KV+DFGL++ Sbjct: 120 DLGYIHRDLAARNILVDGRLVCKVSDFGLSR 150
>EPHB3_MOUSE (P54754) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4) Length = 993 Score = 80.1 bits (196), Expect = 5e-15 Identities = 51/146 (34%), Positives = 85/146 (58%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V +G L LPG +V VA+K L+ + DF+SE S +G+ H NI+ L Sbjct: 634 IGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLE 693 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M N ++D ++ + F+ +L + GIA G+ YL +M + Sbjct: 694 GVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYL---SEMNYV 750 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 751 HRDLAARNILVNSNLVCKVSDFGLSR 776
>CDC2H_THEPA (Q27032) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 79.7 bits (195), Expect = 7e-15 Identities = 50/150 (33%), Positives = 76/150 (50%), Gaps = 1/150 (0%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGDVHVAVKM-LEENSNCNGEDFISEVSTIGRIHHVNIVC 372 H +K+G+G YG VYK G++ K+ +EE I E+S + +HH NIV Sbjct: 5 HKMEKIGEGTYGVVYKAQNNHGEICALKKIRVEEEDEGIPSTAIREISLLKELHHPNIVW 64 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L E LV+EY+ + K + + + I RGI+Y H D + Sbjct: 65 LRDVIHSEKCLTLVFEYLDQ-DLKKLLDACDGGLEPTTAKSFLYQILRGISYCH---DHR 120 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ILH D+KP N+L++ + K+ADFGLA+ + Sbjct: 121 ILHRDLKPQNLLINREGVLKLADFGLARAF 150
>CDC2H_THEAN (Q26671) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 79.7 bits (195), Expect = 7e-15 Identities = 50/150 (33%), Positives = 76/150 (50%), Gaps = 1/150 (0%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGDVHVAVKM-LEENSNCNGEDFISEVSTIGRIHHVNIVC 372 H +K+G+G YG VYK G++ K+ +EE I E+S + +HH NIV Sbjct: 5 HKMEKIGEGTYGVVYKAQNNHGEICALKKIRVEEEDEGIPSTAIREISLLKELHHPNIVW 64 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L E LV+EY+ + K + + + I RGI+Y H D + Sbjct: 65 LRDVIHSEKCLTLVFEYLDQ-DLKKLLDACDGGLEPTTAKSFLYQILRGISYCH---DHR 120 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ILH D+KP N+L++ + K+ADFGLA+ + Sbjct: 121 ILHRDLKPQNLLINREGVLKLADFGLARAF 150
>EPHB4_HUMAN (P54760) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HTK) Length = 987 Score = 79.7 bits (195), Expect = 7e-15 Identities = 50/146 (34%), Positives = 83/146 (56%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPGDVH--VAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V +G L PG VA+K L+ + +F+SE S +G+ H NI+ L Sbjct: 621 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLE 680 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G + M ++ E+M NG++D ++ + F+ +L + GIA G+ YL +M + Sbjct: 681 GVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYL---AEMSYV 737 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 738 HRDLAARNILVNSNLVCKVSDFGLSR 763
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 79.3 bits (194), Expect = 9e-15 Identities = 50/155 (32%), Positives = 84/155 (54%) Frame = +1 Query: 169 YTDIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGR 348 Y +I A ++G G +GTVYKG GDV V + + + + + F +EV+ + + Sbjct: 341 YWEIEASEVMLSTRIGSGSFGTVYKGKW-HGDVAVKILKVVDPTPEQFQAFRNEVAVLRK 399 Query: 349 IHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINY 528 HVNI+ +G+ +++ A+V ++ S+ K++ E F +L +IA A+G++Y Sbjct: 400 TRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDY 458 Query: 529 LHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLA 633 LH I+H D+K +NI L K+ DFGLA Sbjct: 459 LHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLA 490
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 79.3 bits (194), Expect = 9e-15 Identities = 50/155 (32%), Positives = 84/155 (54%) Frame = +1 Query: 169 YTDIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGR 348 Y +I A ++G G +GTVYKG GDV V + + + + + F +EV+ + + Sbjct: 341 YWEIEASEVMLSTRIGSGSFGTVYKGKW-HGDVAVKILKVVDPTPEQFQAFRNEVAVLRK 399 Query: 349 IHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINY 528 HVNI+ +G+ +++ A+V ++ S+ K++ E F +L +IA A+G++Y Sbjct: 400 TRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDY 458 Query: 529 LHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLA 633 LH I+H D+K +NI L K+ DFGLA Sbjct: 459 LHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLA 490
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 79.3 bits (194), Expect = 9e-15 Identities = 52/147 (35%), Positives = 80/147 (54%), Gaps = 1/147 (0%) Frame = +1 Query: 202 RDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVG 381 + KLG G YG VY GV + VAVK L+E++ E+F+ E + + I H N+V L+G Sbjct: 291 KHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDT-MEVEEFLKEAAVMKEIKHPNLVQLLG 349 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEK-SFSWDKLNEIALGIARGINYLHQGCDMQIL 558 C+ E +V EYMP G++ Y+ + + L +A I+ + YL + + Sbjct: 350 VCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEK---KNFI 406 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ N L+ N + KVADFGL++L Sbjct: 407 HRDLAARNCLVGENHVVKVADFGLSRL 433
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 79.3 bits (194), Expect = 9e-15 Identities = 52/152 (34%), Positives = 81/152 (53%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG VA+K + S G I E+S + +HH NIVCL Sbjct: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELHHPNIVCLQ 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDK--LNEIALGIARGINYLHQGCD 546 ++ R L++E++ SMD KY+ + D+ + I +GI + H Sbjct: 68 DVLMQDARLYLIFEFL---SMDLKKYLDTIPSGQYLDRSRVKSYLYQILQGIVFCHS--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+D + K+ADFGLA+ + Sbjct: 122 RRVLHRDLKPQNLLIDDKGVIKLADFGLARAF 153
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 79.0 bits (193), Expect = 1e-14 Identities = 50/152 (32%), Positives = 78/152 (51%), Gaps = 5/152 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 HF + +G+G +G VY G LL D +H AVK L ++ F++E + H N Sbjct: 1080 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 1139 Query: 364 IVCLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 ++ L+G C E +V YM +G + +I + + + L L +A+G+ YL Sbjct: 1140 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL--- 1196 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +H D+ N +LD NF KVADFGLA+ Sbjct: 1197 ASKKFVHRDLAARNCMLDENFTVKVADFGLAR 1228
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 79.0 bits (193), Expect = 1e-14 Identities = 49/151 (32%), Positives = 85/151 (56%), Gaps = 9/151 (5%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGE-DFISEVSTIGRIHHVNIVCLVGFC 387 +G+GG G Y+ P + VA+K L+ S+ + +F++E + +G+ H N++ L+G Sbjct: 728 MGRGGGGGGYESE--PYET-VAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVV 784 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE---KSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 + +V EYM NGS+D+++ + + + W+K+ E+ GIA G+ YL DM + Sbjct: 785 TSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKYL---TDMGYV 841 Query: 559 H-----FDIKPHNILLDSNFIPKVADFGLAK 636 H D+ N+LLD K+ADFGL++ Sbjct: 842 HRVSFLRDLAARNVLLDMELRCKIADFGLSR 872
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 79.0 bits (193), Expect = 1e-14 Identities = 50/155 (32%), Positives = 84/155 (54%) Frame = +1 Query: 169 YTDIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGR 348 Y +I A ++G G +GTVYKG GDV V + + + + + F +EV+ + + Sbjct: 341 YWEIEASEVMLSTRIGSGSFGTVYKGKW-HGDVAVKILKVVDPTPEQLQAFRNEVAVLRK 399 Query: 349 IHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINY 528 HVNI+ +G+ +++ A+V ++ S+ K++ E F +L +IA A+G++Y Sbjct: 400 TRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDY 458 Query: 529 LHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLA 633 LH I+H D+K +NI L K+ DFGLA Sbjct: 459 LHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLA 490
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 79.0 bits (193), Expect = 1e-14 Identities = 50/155 (32%), Positives = 84/155 (54%) Frame = +1 Query: 169 YTDIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGR 348 Y +I A ++G G +GTVYKG GDV V + + + + + F +EV+ + + Sbjct: 341 YWEIEASEVMLSTRIGSGSFGTVYKGKW-HGDVAVKILKVVDPTPEQLQAFRNEVAVLRK 399 Query: 349 IHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINY 528 HVNI+ +G+ +++ A+V ++ S+ K++ E F +L +IA A+G++Y Sbjct: 400 TRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDY 458 Query: 529 LHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLA 633 LH I+H D+K +NI L K+ DFGLA Sbjct: 459 LHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLA 490
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 79.0 bits (193), Expect = 1e-14 Identities = 52/152 (34%), Positives = 82/152 (53%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKGV VA+K + + G I E+S + + H NIVCL+ Sbjct: 8 EKIGEGTYGVVYKGVHKATGQIVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLL 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDKL--NEIALGIARGINYLHQGCD 546 ++ R L++E++ SMD KY+ S + + I +GI + H Sbjct: 68 DVLMQDSRLYLIFEFL---SMDLKKYLDSIPSGQYLEAMLVKSYLYQILQGIIFCHA--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+DS + K+ADFGLA+ + Sbjct: 122 RRVLHRDLKPQNLLIDSKGVIKLADFGLARAF 153
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 79.0 bits (193), Expect = 1e-14 Identities = 50/155 (32%), Positives = 84/155 (54%) Frame = +1 Query: 169 YTDIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGR 348 Y +I A ++G G +GTVYKG GDV V + + + + + F +EV+ + + Sbjct: 74 YWEIEASEVLLSTRIGSGSFGTVYKGKW-HGDVAVKILKVVDPTPEQFQAFRNEVAVLRK 132 Query: 349 IHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINY 528 HVNI+ +G+ +++ A+V ++ S+ K++ E F +L +IA A+G++Y Sbjct: 133 TRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDY 191 Query: 529 LHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLA 633 LH I+H D+K +NI L K+ DFGLA Sbjct: 192 LHA---KNIIHRDMKSNNIFLHGGLTVKIGDFGLA 223
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 78.6 bits (192), Expect = 1e-14 Identities = 49/144 (34%), Positives = 82/144 (56%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 +LG G +G V++G L G VAVK L+ + + E+F+ E S + R+ H ++ L C Sbjct: 245 RLGAGQFGEVWEG-LWNGTTSVAVKTLKPGT-MSVEEFLQEASIMKRLRHPKLIQLYAVC 302 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFD 567 ++E +V E M GS+ +Y+ + ++L ++A +A G++YL Q +H D Sbjct: 303 TKEEPIYIVTELMKYGSLLEYLRGEDGVLKIEQLVDVAAQVASGMSYLEQ---QNYIHRD 359 Query: 568 IKPHNILLDSNFIPKVADFGLAKL 639 + NIL+ + I KVADFGLA++ Sbjct: 360 LAARNILVGEHGICKVADFGLARV 383
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 78.6 bits (192), Expect = 1e-14 Identities = 51/147 (34%), Positives = 76/147 (51%), Gaps = 5/147 (3%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENS---NCNGEDFISEVSTIGRIHHVNIVCLVG 381 L +G GTV V VAVK L ++ + D + E + + I+ ++G Sbjct: 24 LSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSERNDILREAEILHKARFSYILPILG 83 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEK--SFSWDKLNEIALGIARGINYLHQGCDMQI 555 C+E +V EYMPNGS+++ + + +W I IA G+NYLH + + Sbjct: 84 ICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRILHEIALGVNYLHN-MNPPL 142 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAK 636 LH D+K NILLD+ F K+ADFGL+K Sbjct: 143 LHHDLKTQNILLDNEFHVKIADFGLSK 169
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 78.6 bits (192), Expect = 1e-14 Identities = 49/155 (31%), Positives = 84/155 (54%) Frame = +1 Query: 169 YTDIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGR 348 Y +IIA ++G G +GTVYKG GDV V + + + + + F +EV+ + + Sbjct: 332 YWEIIASEVMLSSRIGSGSFGTVYKGKW-HGDVAVKILKVTDPTPEQLQAFRNEVAVLRK 390 Query: 349 IHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINY 528 HVNI+ +G+ +++ A+V ++ S+ ++ + F +L +IA A+G++Y Sbjct: 391 TRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYYHLHVLDTKFQMFQLIDIARQTAQGMDY 449 Query: 529 LHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLA 633 LH I+H D+K +NI L K+ DFGLA Sbjct: 450 LHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLA 481
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 78.2 bits (191), Expect = 2e-14 Identities = 49/146 (33%), Positives = 83/146 (56%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPGDVH--VAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V +G L PG VA+K L+ + +F+SE S +G+ H NI+ L Sbjct: 621 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLE 680 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G + + ++ E+M NG++D ++ + F+ +L + GIA G+ YL +M + Sbjct: 681 GVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYL---AEMSYV 737 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 738 HRDLAARNILVNSNLVCKVSDFGLSR 763
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 78.2 bits (191), Expect = 2e-14 Identities = 47/142 (33%), Positives = 80/142 (56%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 ++G G +GTVYKG GDV V + + + + + F +EV+ + + HVNI+ +G+ Sbjct: 29 RIGSGSFGTVYKGKW-HGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYM 87 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFD 567 +++ A+V ++ S+ K++ E F +L +IA A+G++YLH I+H D Sbjct: 88 TKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHA---KNIIHRD 143 Query: 568 IKPHNILLDSNFIPKVADFGLA 633 +K +NI L K+ DFGLA Sbjct: 144 MKSNNIFLHEGLTVKIGDFGLA 165
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 78.2 bits (191), Expect = 2e-14 Identities = 48/146 (32%), Positives = 80/146 (54%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPG---DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V +G L + VA+K L+ + DF+ E S +G+ H NI+ L Sbjct: 615 IGAGEFGEVCRGKLKQAGRREQFVAIKTLKAGYTEQQRRDFLGEASIMGQFDHPNIIRLE 674 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G + ++ E+M NG++D ++ + F+ +L I GIA G+ YL +M + Sbjct: 675 GVVTRSRPVMILTEFMENGALDSFLRMNDGQFTVIQLVGILRGIASGMKYL---SEMNYV 731 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 732 HRDLAARNILVNSNLVCKVSDFGLSR 757
>EPHB3_HUMAN (P54753) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HEK-2) Length = 998 Score = 77.8 bits (190), Expect = 3e-14 Identities = 50/146 (34%), Positives = 84/146 (57%), Gaps = 4/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVLL-PG--DVHVAVKMLEEN-SNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V +G L PG +V VA+K L+ + DF+SE S +G+ H NI+ L Sbjct: 639 IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLE 698 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M N ++D ++ + F+ +L + GIA G+ YL +M + Sbjct: 699 GVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYL---SEMNYV 755 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ NIL++SN + KV+DFGL++ Sbjct: 756 HRDLAARNILVNSNLVCKVSDFGLSR 781
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 77.8 bits (190), Expect = 3e-14 Identities = 52/152 (34%), Positives = 81/152 (53%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG VA+K + + G I E+S + + H NIVCL+ Sbjct: 8 EKIGEGTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLL 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDKL--NEIALGIARGINYLHQGCD 546 ++ R L++E++ SMD KY+ S D + I +GI + H Sbjct: 68 DVLMQDSRLYLIFEFL---SMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHS--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+DS + K+ADFGLA+ + Sbjct: 122 RRVLHRDLKPQNLLIDSKGVIKLADFGLARAF 153
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 77.8 bits (190), Expect = 3e-14 Identities = 45/152 (29%), Positives = 78/152 (51%) Frame = +1 Query: 184 AITRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVN 363 ++ H + +G+G YG VYK + D VA+K + ++ D ++E+S + ++H N Sbjct: 22 SVQYHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNN 81 Query: 364 IVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGC 543 IV GF + ++ EY NGS+ + I + S ++ G+ YLH Sbjct: 82 IVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLH--- 138 Query: 544 DMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 ++H DIK NILL ++ K+ADFG++ + Sbjct: 139 GEGVIHRDIKAANILLSADNTVKLADFGVSTI 170
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 77.4 bits (189), Expect = 3e-14 Identities = 50/147 (34%), Positives = 80/147 (54%), Gaps = 1/147 (0%) Frame = +1 Query: 202 RDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVG 381 + KLG G YG VY+GV + VAVK L+E++ E+F+ E + + I H N+V L+G Sbjct: 131 KHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT-MEVEEFLKEAAVMKEIKHPNLVQLLG 189 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEK-SFSWDKLNEIALGIARGINYLHQGCDMQIL 558 C+ E ++ E+M G++ Y+ + S L +A I+ + YL + + Sbjct: 190 VCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEK---KNFI 246 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ N L+ N + KVADFGL++L Sbjct: 247 HRDLAARNCLVGENHLVKVADFGLSRL 273
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 77.4 bits (189), Expect = 3e-14 Identities = 50/147 (34%), Positives = 80/147 (54%), Gaps = 1/147 (0%) Frame = +1 Query: 202 RDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVG 381 + KLG G YG VY+GV + VAVK L+E++ E+F+ E + + I H N+V L+G Sbjct: 245 KHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT-MEVEEFLKEAAVMKEIKHPNLVQLLG 303 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEK-SFSWDKLNEIALGIARGINYLHQGCDMQIL 558 C+ E ++ E+M G++ Y+ + S L +A I+ + YL + + Sbjct: 304 VCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEK---KNFI 360 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ N L+ N + KVADFGL++L Sbjct: 361 HRDLAARNCLVGENHLVKVADFGLSRL 387
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 77.4 bits (189), Expect = 3e-14 Identities = 51/147 (34%), Positives = 76/147 (51%), Gaps = 5/147 (3%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENS---NCNGEDFISEVSTIGRIHHVNIVCLVG 381 L +G GTV V VAVK L ++ + +D + E + + I+ ++G Sbjct: 24 LSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILG 83 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEK--SFSWDKLNEIALGIARGINYLHQGCDMQI 555 C+E +V EYMPNGS+++ + + +W I IA G+NYLH + Sbjct: 84 ICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHN-MTPPL 142 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAK 636 LH D+K NILLD+ F K+ADFGL+K Sbjct: 143 LHHDLKTQNILLDNEFHVKIADFGLSK 169
>CDC2_DROME (P23572) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 297 Score = 77.4 bits (189), Expect = 3e-14 Identities = 55/153 (35%), Positives = 84/153 (54%), Gaps = 7/153 (4%) Frame = +1 Query: 205 DKLGQGGYGTVYKGV-LLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCL 375 +K+G+G YG VYKG L G + VA+K + S+ G I E+S + + H NIVCL Sbjct: 8 EKIGEGTYGVVYKGRNRLTGQI-VAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCL 66 Query: 376 VGFCSEEMRRALVYEYMPNGSMD--KYIFS--AEKSFSWDKLNEIALGIARGINYLHQGC 543 EE R L++E++ SMD KY+ S +K + + I I + H+ Sbjct: 67 EDVLMEENRIYLIFEFL---SMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHR-- 121 Query: 544 DMQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+D + + KVADFGL + + Sbjct: 122 -RRVLHRDLKPQNLLIDKSGLIKVADFGLGRSF 153
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 77.0 bits (188), Expect = 4e-14 Identities = 51/147 (34%), Positives = 82/147 (55%), Gaps = 1/147 (0%) Frame = +1 Query: 202 RDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVG 381 + KLG G YG VY+ V VAVK L+E++ +DF+ E + + + H N+V L+G Sbjct: 374 KHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMAL-KDFLEEAAIMKEMKHPNLVQLIG 432 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSA-EKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 C+ E ++ E+M +G++ ++ SA ++ L +A IA G++YL + Sbjct: 433 VCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLE---SRNYI 489 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ N L+ N + KVADFGLA+L Sbjct: 490 HRDLAARNCLVGDNKLVKVADFGLARL 516
>MET_PIG (Q2QLE0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 76.6 bits (187), Expect = 6e-14 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 HF + +G+G +G VY G LL D +H AVK L ++ F++E + H N Sbjct: 1079 HFNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 1138 Query: 364 IVCLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 ++ L+G C E +V YM +G + +I + + + L L +A+G+ YL Sbjct: 1139 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL--- 1195 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +H D+ N +LD F KVADFGLA+ Sbjct: 1196 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR 1227
>MET_HORSE (Q2QLA9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 76.6 bits (187), Expect = 6e-14 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 HF + +G+G +G VY G LL D +H AVK L ++ F++E + H N Sbjct: 1079 HFNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 1138 Query: 364 IVCLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 ++ L+G C E +V YM +G + +I + + + L L +A+G+ YL Sbjct: 1139 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL--- 1195 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +H D+ N +LD F KVADFGLA+ Sbjct: 1196 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR 1227
>MET_CALMO (Q2QLC0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 76.6 bits (187), Expect = 6e-14 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 HF + +G+G +G VY G LL D +H AVK L ++ F++E + H N Sbjct: 1079 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 1138 Query: 364 IVCLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 ++ L+G C E +V YM +G + +I + + + L L +A+G+ YL Sbjct: 1139 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL--- 1195 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +H D+ N +LD F KVADFGLA+ Sbjct: 1196 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR 1227
>MET_CALJA (Q2QLG5) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 76.6 bits (187), Expect = 6e-14 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 HF + +G+G +G VY G LL D +H AVK L ++ F++E + H N Sbjct: 1079 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 1138 Query: 364 IVCLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 ++ L+G C E +V YM +G + +I + + + L L +A+G+ YL Sbjct: 1139 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL--- 1195 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +H D+ N +LD F KVADFGLA+ Sbjct: 1196 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR 1227
>MET_PONPY (Q2IBD8) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 76.6 bits (187), Expect = 6e-14 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 HF + +G+G +G VY G LL D +H AVK L ++ F++E + H N Sbjct: 1079 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 1138 Query: 364 IVCLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 ++ L+G C E +V YM +G + +I + + + L L +A+G+ YL Sbjct: 1139 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL--- 1195 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +H D+ N +LD F KVADFGLA+ Sbjct: 1196 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR 1227
>MET_PANTR (Q2QLF1) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 76.6 bits (187), Expect = 6e-14 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 HF + +G+G +G VY G LL D +H AVK L ++ F++E + H N Sbjct: 1079 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 1138 Query: 364 IVCLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 ++ L+G C E +V YM +G + +I + + + L L +A+G+ YL Sbjct: 1139 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL--- 1195 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +H D+ N +LD F KVADFGLA+ Sbjct: 1196 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR 1227
>MET_HUMAN (P08581) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 76.6 bits (187), Expect = 6e-14 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 HF + +G+G +G VY G LL D +H AVK L ++ F++E + H N Sbjct: 1079 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 1138 Query: 364 IVCLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 ++ L+G C E +V YM +G + +I + + + L L +A+G+ YL Sbjct: 1139 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL--- 1195 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +H D+ N +LD F KVADFGLA+ Sbjct: 1196 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR 1227
>MET_MICMU (Q2QL89) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 76.6 bits (187), Expect = 6e-14 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 HF + +G+G +G VY G LL D +H AVK L ++ F++E + H N Sbjct: 1080 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 1139 Query: 364 IVCLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 ++ L+G C E +V YM +G + +I + + + L L +A+G+ YL Sbjct: 1140 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL--- 1196 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +H D+ N +LD F KVADFGLA+ Sbjct: 1197 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR 1228
>MET_CANFA (Q75ZY9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 76.6 bits (187), Expect = 6e-14 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 HF + +G+G +G VY G LL D +H AVK L ++ F++E + H N Sbjct: 1080 HFNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 1139 Query: 364 IVCLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 ++ L+G C E +V YM +G + +I + + + L L +A+G+ YL Sbjct: 1140 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL--- 1196 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +H D+ N +LD F KVADFGLA+ Sbjct: 1197 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR 1228
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 76.6 bits (187), Expect = 6e-14 Identities = 52/144 (36%), Positives = 80/144 (55%), Gaps = 2/144 (1%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGE--DFISEVSTIGRIHHVNIVCLVG 381 ++G G +GTVYKG GDV AVKML + + F +EV + + HVNI+ +G Sbjct: 502 RIGSGSFGTVYKGKW-HGDV--AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG 558 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILH 561 + S + + A+V ++ S+ ++ E F KL +IA A+G++YLH I+H Sbjct: 559 Y-STKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA---KSIIH 614 Query: 562 FDIKPHNILLDSNFIPKVADFGLA 633 D+K +NI L + K+ DFGLA Sbjct: 615 RDLKSNNIFLHEDLTVKIGDFGLA 638
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 76.6 bits (187), Expect = 6e-14 Identities = 52/144 (36%), Positives = 80/144 (55%), Gaps = 2/144 (1%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGE--DFISEVSTIGRIHHVNIVCLVG 381 ++G G +GTVYKG GDV AVKML + + F +EV + + HVNI+ +G Sbjct: 88 RIGSGSFGTVYKGKW-HGDV--AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG 144 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILH 561 + S + + A+V ++ S+ ++ E F KL +IA A+G++YLH I+H Sbjct: 145 Y-STKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA---KSIIH 200 Query: 562 FDIKPHNILLDSNFIPKVADFGLA 633 D+K +NI L + K+ DFGLA Sbjct: 201 RDLKSNNIFLHEDLTVKIGDFGLA 224
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 76.6 bits (187), Expect = 6e-14 Identities = 52/144 (36%), Positives = 80/144 (55%), Gaps = 2/144 (1%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGE--DFISEVSTIGRIHHVNIVCLVG 381 ++G G +GTVYKG GDV AVKML + + F +EV + + HVNI+ +G Sbjct: 462 RIGSGSFGTVYKGKW-HGDV--AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG 518 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILH 561 + S + + A+V ++ S+ ++ E F KL +IA A+G++YLH I+H Sbjct: 519 Y-STKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA---KSIIH 574 Query: 562 FDIKPHNILLDSNFIPKVADFGLA 633 D+K +NI L + K+ DFGLA Sbjct: 575 RDLKSNNIFLHEDLTVKIGDFGLA 598
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 76.6 bits (187), Expect = 6e-14 Identities = 52/144 (36%), Positives = 80/144 (55%), Gaps = 2/144 (1%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGE--DFISEVSTIGRIHHVNIVCLVG 381 ++G G +GTVYKG GDV AVKML + + F +EV + + HVNI+ +G Sbjct: 24 RIGSGSFGTVYKGKW-HGDV--AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG 80 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILH 561 + S + + A+V ++ S+ ++ E F KL +IA A+G++YLH I+H Sbjct: 81 Y-STKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA---KSIIH 136 Query: 562 FDIKPHNILLDSNFIPKVADFGLA 633 D+K +NI L + K+ DFGLA Sbjct: 137 RDLKSNNIFLHEDLTVKIGDFGLA 160
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 76.6 bits (187), Expect = 6e-14 Identities = 52/144 (36%), Positives = 80/144 (55%), Gaps = 2/144 (1%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGE--DFISEVSTIGRIHHVNIVCLVG 381 ++G G +GTVYKG GDV AVKML + + F +EV + + HVNI+ +G Sbjct: 502 RIGSGSFGTVYKGKW-HGDV--AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG 558 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILH 561 + S + + A+V ++ S+ ++ E F KL +IA A+G++YLH I+H Sbjct: 559 Y-STKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA---KSIIH 614 Query: 562 FDIKPHNILLDSNFIPKVADFGLA 633 D+K +NI L + K+ DFGLA Sbjct: 615 RDLKSNNIFLHEDLTVKIGDFGLA 638
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 76.6 bits (187), Expect = 6e-14 Identities = 52/144 (36%), Positives = 80/144 (55%), Gaps = 2/144 (1%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGE--DFISEVSTIGRIHHVNIVCLVG 381 ++G G +GTVYKG GDV AVKML + + F +EV + + HVNI+ +G Sbjct: 72 RIGSGSFGTVYKGKW-HGDV--AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG 128 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILH 561 + S + + A+V ++ S+ ++ E F KL +IA A+G++YLH I+H Sbjct: 129 Y-STKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA---KSIIH 184 Query: 562 FDIKPHNILLDSNFIPKVADFGLA 633 D+K +NI L + K+ DFGLA Sbjct: 185 RDLKSNNIFLHEDLTVKIGDFGLA 208
>MET_MOUSE (P16056) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1379 Score = 76.6 bits (187), Expect = 6e-14 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 HF + +G+G +G VY G LL D +H AVK L ++ F++E + H N Sbjct: 1077 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPN 1136 Query: 364 IVCLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 ++ L+G C E +V YM +G + +I + + + L L +A+G+ YL Sbjct: 1137 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL--- 1193 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +H D+ N +LD F KVADFGLA+ Sbjct: 1194 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR 1225
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 76.3 bits (186), Expect = 7e-14 Identities = 50/152 (32%), Positives = 79/152 (51%), Gaps = 7/152 (4%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKML------EENSNCNGEDFISEVSTIGRIHHVNI 366 +K G + +Y+G+ V AVKM+ EE + F SEV+ + R+ H NI Sbjct: 90 NKFASGAHSRIYRGIYKQRAV--AVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNI 147 Query: 367 VCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEK-SFSWDKLNEIALGIARGINYLHQGC 543 V + C + ++ EYM G++ Y+ E S S + + +AL I+RG+ YLH Sbjct: 148 VQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLH--- 204 Query: 544 DMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 ++H D+K +N+LL+ KVADFG + L Sbjct: 205 SQGVIHRDLKSNNLLLNDEMRVKVADFGTSCL 236
>MET_RAT (P97523) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 76.3 bits (186), Expect = 7e-14 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD---VHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 HF + +G+G +G VY G LL D +H AVK L ++ F++E + H N Sbjct: 1080 HFNEVIGRGHFGCVYHGTLLDSDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPN 1139 Query: 364 IVCLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 ++ L+G C E +V YM +G + +I + + + L L +A+G+ YL Sbjct: 1140 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL--- 1196 Query: 541 CDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + +H D+ N +LD F KVADFGLA+ Sbjct: 1197 VSKKFVHRDLAARNCMLDEKFTVKVADFGLAR 1228
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 76.3 bits (186), Expect = 7e-14 Identities = 49/147 (33%), Positives = 80/147 (54%), Gaps = 1/147 (0%) Frame = +1 Query: 202 RDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVG 381 + KLG G YG VY+GV + VAVK L+E++ E+F+ E + + I H N+V L+G Sbjct: 245 KHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT-MEVEEFLKEAAVMKEIKHPNLVQLLG 303 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEK-SFSWDKLNEIALGIARGINYLHQGCDMQIL 558 C+ E ++ E+M G++ Y+ + + L +A I+ + YL + + Sbjct: 304 VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK---KNFI 360 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ N L+ N + KVADFGL++L Sbjct: 361 HRDLAARNCLVGENHLVKVADFGLSRL 387
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 76.3 bits (186), Expect = 7e-14 Identities = 53/156 (33%), Positives = 84/156 (53%), Gaps = 1/156 (0%) Frame = +1 Query: 175 DIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIH 354 +I T + KLGQG +G V+ GV G VAVK L+ ++ +DF+ E + +IH Sbjct: 60 EIDRTTIQLQRKLGQGNFGEVWAGVW-NGTTAVAVKTLKPDT-MEVKDFVQEAQVMKKIH 117 Query: 355 HVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYL 531 H N++ L C+ +V E M GSM +Y+ E K+ + ++ +++ IA G+ YL Sbjct: 118 HPNLLQLYAVCTIGEPIYIVTELMKYGSMLEYLKHGEGKNITLHQMVDMSAQIASGMTYL 177 Query: 532 HQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 +H D+ NIL+ + KVADFGLA++ Sbjct: 178 EA---HSYIHRDLAARNILVGEGNVCKVADFGLARV 210
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 76.3 bits (186), Expect = 7e-14 Identities = 49/147 (33%), Positives = 80/147 (54%), Gaps = 1/147 (0%) Frame = +1 Query: 202 RDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVG 381 + KLG G YG VY+GV + VAVK L+E++ E+F+ E + + I H N+V L+G Sbjct: 194 KHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT-MEVEEFLKEAAVMKEIKHPNLVQLLG 252 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEK-SFSWDKLNEIALGIARGINYLHQGCDMQIL 558 C+ E ++ E+M G++ Y+ + + L +A I+ + YL + + Sbjct: 253 VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK---KNFI 309 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ N L+ N + KVADFGL++L Sbjct: 310 HRDLAARNCLVGENHLVKVADFGLSRL 336
>PCTK1_MOUSE (Q04735) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) (CRK5) Length = 496 Score = 76.3 bits (186), Expect = 7e-14 Identities = 51/148 (34%), Positives = 75/148 (50%), Gaps = 4/148 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKML----EENSNCNGEDFISEVSTIGRIHHVNIVC 372 DKLG+G Y TVYKG D VA+K + EE + C I EVS + + H NIV Sbjct: 169 DKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTA---IREVSLLKDLKHANIVT 225 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L E LV+EY+ + +Y+ + + + RG+ Y H+ + Sbjct: 226 LHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHR---QK 281 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAK 636 +LH D+KP N+L++ K+ADFGLA+ Sbjct: 282 VLHRDLKPQNLLINERGELKLADFGLAR 309
>PCTK1_HUMAN (Q00536) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 76.3 bits (186), Expect = 7e-14 Identities = 51/148 (34%), Positives = 75/148 (50%), Gaps = 4/148 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKML----EENSNCNGEDFISEVSTIGRIHHVNIVC 372 DKLG+G Y TVYKG D VA+K + EE + C I EVS + + H NIV Sbjct: 169 DKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTA---IREVSLLKDLKHANIVT 225 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L E LV+EY+ + +Y+ + + + RG+ Y H+ + Sbjct: 226 LHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHR---QK 281 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAK 636 +LH D+KP N+L++ K+ADFGLA+ Sbjct: 282 VLHRDLKPQNLLINERGELKLADFGLAR 309
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 75.9 bits (185), Expect = 1e-13 Identities = 55/180 (30%), Positives = 89/180 (49%), Gaps = 19/180 (10%) Frame = +1 Query: 154 PTRYAYTDIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHV--AVKMLEEN-SNCNGEDFI 324 PT Y D I F+D +G+G +G V K + + + A+K ++E S + DF Sbjct: 811 PTIYPVLDWNDIK--FQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFA 868 Query: 325 SEVSTIGRI-HHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIF--------------- 456 E+ + ++ HH NI+ L+G C L EY P+G++ ++ Sbjct: 869 GELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIAN 928 Query: 457 SAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 S + S +L A +ARG++YL Q Q +H D+ NIL+ N+I K+ADFGL++ Sbjct: 929 STASTLSSQQLLHFAADVARGMDYLSQ---KQFIHRDLAARNILVGENYIAKIADFGLSR 985
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 75.5 bits (184), Expect = 1e-13 Identities = 54/180 (30%), Positives = 89/180 (49%), Gaps = 19/180 (10%) Frame = +1 Query: 154 PTRYAYTDIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHV--AVKMLEEN-SNCNGEDFI 324 PT Y D I F+D +G+G +G V K + + + A+K ++E S + DF Sbjct: 813 PTIYPVLDWNDIK--FQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFA 870 Query: 325 SEVSTIGRI-HHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIF--------------- 456 E+ + ++ HH NI+ L+G C L EY P+G++ ++ Sbjct: 871 GELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIAN 930 Query: 457 SAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 S + S +L A +ARG++YL Q Q +H D+ NIL+ N++ K+ADFGL++ Sbjct: 931 STASTLSSQQLLHFAADVARGMDYLSQ---KQFIHRDLAARNILVGENYVAKIADFGLSR 987
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 75.5 bits (184), Expect = 1e-13 Identities = 54/180 (30%), Positives = 89/180 (49%), Gaps = 19/180 (10%) Frame = +1 Query: 154 PTRYAYTDIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHV--AVKMLEEN-SNCNGEDFI 324 PT Y D I F+D +G+G +G V K + + + A+K ++E S + DF Sbjct: 814 PTIYPVLDWNDIK--FQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFA 871 Query: 325 SEVSTIGRI-HHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIF--------------- 456 E+ + ++ HH NI+ L+G C L EY P+G++ ++ Sbjct: 872 GELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIAN 931 Query: 457 SAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 S + S +L A +ARG++YL Q Q +H D+ NIL+ N++ K+ADFGL++ Sbjct: 932 STASTLSSQQLLHFAADVARGMDYLSQ---KQFIHRDLAARNILVGENYVAKIADFGLSR 988
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 75.5 bits (184), Expect = 1e-13 Identities = 49/148 (33%), Positives = 83/148 (56%), Gaps = 5/148 (3%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPGD--VHVAVKMLEENSNCNGE--DFISEVSTIGRIHHVNIVCL 375 +G+G +G VY+G L LP VA+K L++ S G+ +F+ E + +G+ H +I+ L Sbjct: 630 IGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSP-GGQWWNFLREATIMGQFSHPHILHL 688 Query: 376 VGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQI 555 G ++ ++ E+M NG++D ++ E +L + GIA G+NYL + Sbjct: 689 EGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYL---SNHNY 745 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAKL 639 +H D+ NIL++ N KV+DFGL +L Sbjct: 746 VHRDLAARNILVNQNLCCKVSDFGLTRL 773
>DDR2_MOUSE (Q62371) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 854 Score = 75.5 bits (184), Expect = 1e-13 Identities = 50/171 (29%), Positives = 85/171 (49%), Gaps = 25/171 (14%) Frame = +1 Query: 199 FRDKLGQGGYGTVYK----------------GVLLPGDVHVAVKMLEENSNCNGE-DFIS 327 F++KLG+G +G V+ V V VAVKML ++N N DF+ Sbjct: 565 FKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLK 624 Query: 328 EVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYI--------FSAEKSFSWD 483 E+ + R+ NI+ L+ C E ++ EYM NG +++++ S++ + S+ Sbjct: 625 EIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMENGDLNQFLSRHEPLSSCSSDATVSYA 684 Query: 484 KLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 L +A IA G+ YL + +H D+ N L+ N+ K+ADFG+++ Sbjct: 685 NLKFMATQIASGMKYL---SSLNFVHRDLATRNCLVGKNYTIKIADFGMSR 732
>CDC22_XENLA (P24033) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 2) Length = 302 Score = 75.5 bits (184), Expect = 1e-13 Identities = 51/152 (33%), Positives = 80/152 (52%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG VA+K + + G I E+S + + H NIVCL+ Sbjct: 8 EKIGEGTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLL 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDKL--NEIALGIARGINYLHQGCD 546 ++ R L++E++ SMD KY+ S D + I +GI + H Sbjct: 68 DVLMQDSRLYLIFEFL---SMDVKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHS--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 +LH D+KP N+L+D+ + K+ADFGLA+ + Sbjct: 122 RGVLHRDLKPQNLLIDNKGVIKLADFGLARAF 153
>PCTK1_RAT (Q63686) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 75.5 bits (184), Expect = 1e-13 Identities = 51/147 (34%), Positives = 74/147 (50%), Gaps = 4/147 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKML----EENSNCNGEDFISEVSTIGRIHHVNIVC 372 DKLG+G Y TVYKG D VA+K + EE + C I EVS + + H NIV Sbjct: 169 DKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTA---IREVSLLKDLKHANIVT 225 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L E LV+EY+ + +Y+ + + + RG+ Y H+ + Sbjct: 226 LHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHR---QK 281 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLA 633 +LH D+KP N+L++ K+ADFGLA Sbjct: 282 VLHRDLKPQNLLINERGELKLADFGLA 308
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 75.1 bits (183), Expect = 2e-13 Identities = 46/145 (31%), Positives = 76/145 (52%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLG+G +G V+ G + VAVK L E + F+ E + + + H +V L C Sbjct: 289 KLGRGNFGEVFYGKWR-NSIDVAVKTLREGTMSTAA-FLQEAAIMKKFRHNRLVALYAVC 346 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSF-SWDKLNEIALGIARGINYLHQGCDMQILHF 564 S+E +V EYM GS+ ++ + + ++ L IA +A G+ YL Q++H Sbjct: 347 SQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLES---KQLIHR 403 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D+ N+L+ N + K+ DFGLA++ Sbjct: 404 DLAARNVLIGENNVAKICDFGLARV 428
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 75.1 bits (183), Expect = 2e-13 Identities = 46/143 (32%), Positives = 74/143 (51%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 +LG G +G V G G VAVKM++E S + ++F E T+ ++ H +V G C Sbjct: 422 ELGSGQFGVVQLGKW-KGQYDVAVKMIKEGS-MSEDEFFQEAQTMMKLSHPKLVKFYGVC 479 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFD 567 S+E +V EY+ NG + Y+ S K +L E+ + G+ +L Q +H D Sbjct: 480 SKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLE---SHQFIHRD 536 Query: 568 IKPHNILLDSNFIPKVADFGLAK 636 + N L+D + KV+DFG+ + Sbjct: 537 LAARNCLVDRDLCVKVSDFGMTR 559
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 74.7 bits (182), Expect = 2e-13 Identities = 48/143 (33%), Positives = 80/143 (55%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFCS 390 LG G +G V++G L G VAVK L+ + + E+F+ E S + ++ H ++ L C+ Sbjct: 246 LGAGQFGEVWEG-LWNGTTSVAVKTLKPGT-MSIEEFLEEASIMKQLRHPKLIQLYAVCT 303 Query: 391 EEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFDI 570 +E +V E M +GS+ +Y+ +S L ++ +A G++YL Q +H D+ Sbjct: 304 KEEPIYIVTELMKHGSLLEYLRGDGRSLKLPDLVDMCSQVASGMSYLEQ---QNYIHRDL 360 Query: 571 KPHNILLDSNFIPKVADFGLAKL 639 NIL+ + I KVADFGLA++ Sbjct: 361 AARNILVGEHKICKVADFGLARV 383
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 74.7 bits (182), Expect = 2e-13 Identities = 48/147 (32%), Positives = 83/147 (56%), Gaps = 1/147 (0%) Frame = +1 Query: 202 RDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVG 381 R KLG+G +G V++G+ L G + VAVK+++ +++ D E+ + + H ++ L Sbjct: 237 RRKLGEGFFGEVWEGLWL-GSIPVAVKVIK-SADMKLADLTKEIEALKSLRHERLIRLHA 294 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 CS +V E M G++ Y+ S+E K+ S L A +A G++YL + +++ Sbjct: 295 ICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPHLLGFACQVAEGMSYLEE---RRVV 351 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ N+L+ + KVADFGLA+L Sbjct: 352 HRDLAARNVLVGDDLTCKVADFGLARL 378
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 74.7 bits (182), Expect = 2e-13 Identities = 48/147 (32%), Positives = 83/147 (56%), Gaps = 4/147 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPGD--VHVAVKMLEENS-NCNGEDFISEVSTIGRIHHVNIVCLV 378 +G+G +G VY+G L LP VA+K L++ S + +F+ E + +G+ +H +I+ L Sbjct: 631 IGEGEFGEVYRGALRLPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLE 690 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G ++ ++ E+M NG++D ++ E + +L + LGIA G+N L + Sbjct: 691 GVITKRKPIMIITEFMENGALDAFLKEREDQLAPGQLVAMLLGIASGMNCL---SGHNYV 747 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKL 639 H D+ NIL++ N KV+DFGL +L Sbjct: 748 HRDLAARNILVNQNLCCKVSDFGLTRL 774
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 74.7 bits (182), Expect = 2e-13 Identities = 51/152 (33%), Positives = 80/152 (52%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG VA+K + S G + EVS + + H N+V L+ Sbjct: 8 EKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLL 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDKL--NEIALGIARGINYLHQGCD 546 +E R L++E++ SMD KY+ S D + I GI + H+ Sbjct: 68 DVLMQESRLYLIFEFL---SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHR--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+D+ + K+ADFGLA+ + Sbjct: 122 RRVLHRDLKPQNLLIDNKGVIKLADFGLARAF 153
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 74.7 bits (182), Expect = 2e-13 Identities = 51/152 (33%), Positives = 80/152 (52%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG VA+K + S G + EVS + + H N+V L+ Sbjct: 8 EKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLL 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDKL--NEIALGIARGINYLHQGCD 546 +E R L++E++ SMD KY+ S D + I GI + H+ Sbjct: 68 DVLMQESRLYLIFEFL---SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHR--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+D+ + K+ADFGLA+ + Sbjct: 122 RRVLHRDLKPQNLLIDNKGVIKLADFGLARAF 153
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 74.7 bits (182), Expect = 2e-13 Identities = 51/152 (33%), Positives = 80/152 (52%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG VA+K + S G + EVS + + H N+V L+ Sbjct: 8 EKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLL 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDKL--NEIALGIARGINYLHQGCD 546 +E R L++E++ SMD KY+ S D + I GI + H+ Sbjct: 68 DVLMQESRLYLIFEFL---SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHR--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+D+ + K+ADFGLA+ + Sbjct: 122 RRVLHRDLKPQNLLIDNKGVIKLADFGLARAF 153
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 74.3 bits (181), Expect = 3e-13 Identities = 45/146 (30%), Positives = 76/146 (52%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 F +LG G +G V G G +VA+KM+ E S + ++FI E + + H +V L Sbjct: 402 FLKELGTGQFGVVKYGKWR-GQYNVAIKMIREGS-MSEDEFIDEAKVMMNLSHEKLVQLY 459 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G C+++ ++ EYM NG + ++ ++ F +L E+ + + YL Q L Sbjct: 460 GVCTKQRPIFIITEYMANGCLLNFLRETQRRFQPAELLEMCKDVCEAMEYLE---SKQFL 516 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ N L++ I KV+DFGL++ Sbjct: 517 HRDLAARNCLVNDQGIVKVSDFGLSR 542
>ROR1_MOUSE (Q9Z139) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1) Length = 937 Score = 74.3 bits (181), Expect = 3e-13 Identities = 50/167 (29%), Positives = 83/167 (49%), Gaps = 21/167 (12%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVL-LPGDVH---VAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 F ++LG+ +G +YKG L LPG H VA+K L++ +N +F E S + +HH N Sbjct: 475 FMEELGECTFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPN 534 Query: 364 IVCLVGFCSEEMRRALVYEYMPNGSMDKYIF----------------SAEKSFSWDKLNE 495 IVCL+G ++E +++EYM G + +++ + + S Sbjct: 535 IVCLLGAVTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLH 594 Query: 496 IALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 IA+ IA G+ YL +H D+ NIL+ K++D GL++ Sbjct: 595 IAIQIAAGMEYLSSHF---FVHKDLAARNILIGEQLHVKISDLGLSR 638
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 74.3 bits (181), Expect = 3e-13 Identities = 49/148 (33%), Positives = 76/148 (51%), Gaps = 6/148 (4%) Frame = +1 Query: 208 KLGQGGYGTVY------KGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIV 369 +L GG+G V +G+++ V+ +E N E + E + R+ H +V Sbjct: 22 ELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHN-----EALLEEAKMMNRLRHSRVV 76 Query: 370 CLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDM 549 L+G EE + +LV EYM G++ ++ AE S I L I G+ YLH Sbjct: 77 KLLGVIIEEGKYSLVMEYMEKGNL-MHVLKAEMSTPLSVKGRIILEIIEGMCYLH---GK 132 Query: 550 QILHFDIKPHNILLDSNFIPKVADFGLA 633 ++H D+KP NIL+D++F K+AD GLA Sbjct: 133 GVIHKDLKPENILVDNDFHIKIADLGLA 160
>BTK_HUMAN (Q06187) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 658 Score = 74.3 bits (181), Expect = 3e-13 Identities = 45/146 (30%), Positives = 74/146 (50%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 F +LG G +G V G G VA+KM++E S + ++FI E + + H +V L Sbjct: 403 FLKELGTGQFGVVKYGKWR-GQYDVAIKMIKEGS-MSEDEFIEEAKVMMNLSHEKLVQLY 460 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G C+++ ++ EYM NG + Y+ F +L E+ + + YL Q L Sbjct: 461 GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE---SKQFL 517 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ N L++ + KV+DFGL++ Sbjct: 518 HRDLAARNCLVNDQGVVKVSDFGLSR 543
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 73.9 bits (180), Expect = 4e-13 Identities = 45/146 (30%), Positives = 73/146 (50%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 F +LG G +G V G G VA+KM+ E S + ++FI E + + H +V L Sbjct: 403 FLKELGTGQFGVVKYGKWR-GQYDVAIKMIREGS-MSEDEFIEEAKVMMNLSHEKLVQLY 460 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G C+++ ++ EYM NG + Y+ F +L E+ + + YL Q L Sbjct: 461 GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE---SKQFL 517 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ N L++ + KV+DFGL++ Sbjct: 518 HRDLAARNCLVNDQGVVKVSDFGLSR 543
>JAK_DROME (Q24592) Tyrosine-protein kinase hopscotch (EC 2.7.10.2)| Length = 1177 Score = 73.9 bits (180), Expect = 4e-13 Identities = 54/155 (34%), Positives = 80/155 (51%), Gaps = 8/155 (5%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGD-----VHVAVKMLEENSNCNGEDFISEVSTIGRIHHV 360 + + +G+G YGTVYKG L D VA+KML N+ DF E+ + + H Sbjct: 893 NMENMIGRGHYGTVYKGHLEFNDKDQPREQVAIKML--NTMQVSTDFHREIGIMRTLSHP 950 Query: 361 NIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQG 540 NIV + E ++ EY+ +GS D Y+ + + +L AL IA G+ YL Sbjct: 951 NIVKFKYWA--EKSHCIIMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYL--- 1005 Query: 541 CDMQILHFDIKPHNILLDSN---FIPKVADFGLAK 636 DM ++H D+ NIL+D N K++DFGLA+ Sbjct: 1006 SDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQ 1040
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 73.6 bits (179), Expect = 5e-13 Identities = 46/148 (31%), Positives = 80/148 (54%), Gaps = 5/148 (3%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGD----VHVAVKMLEENSNCNGE-DFISEVSTIGRIHHVNIVCL 375 LG G +GTVYKG+ +P + VA+K+L E + +F+ E + + H ++V L Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRL 783 Query: 376 VGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQI 555 +G C + LV + MP+G + +Y+ + + L + IA+G+ YL + ++ Sbjct: 784 LGVCLSPTIQ-LVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEE---RRL 839 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAKL 639 +H D+ N+L+ S K+ DFGLA+L Sbjct: 840 VHRDLAARNVLVKSPNHVKITDFGLARL 867
>PCTK3_PONPY (Q5RD01) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 73.6 bits (179), Expect = 5e-13 Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 4/148 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKML----EENSNCNGEDFISEVSTIGRIHHVNIVC 372 DKLG+G Y TV+KG + VA+K + EE + C I EVS + + H NIV Sbjct: 146 DKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTA---IREVSLLKNLKHANIVT 202 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L + LV+EY+ + + +Y+ S + + RG+ Y H + Sbjct: 203 LHDLIHTDRSLTLVFEYL-DSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHH---RK 258 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAK 636 ILH D+KP N+L++ K+ADFGLA+ Sbjct: 259 ILHRDLKPQNLLINERGELKLADFGLAR 286
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 73.6 bits (179), Expect = 5e-13 Identities = 50/152 (32%), Positives = 80/152 (52%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG VA+K + S G + EVS + + H N+V L+ Sbjct: 8 EKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLL 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDKL--NEIALGIARGINYLHQGCD 546 +E R L++E++ SMD KY+ S D + I GI + H+ Sbjct: 68 DVLMQESRLYLIFEFL---SMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHR--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+D+ + K+ADFGL++ + Sbjct: 122 RRVLHRDLKPQNLLIDNKGVIKLADFGLSRAF 153
>DDR2_HUMAN (Q16832) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 855 Score = 73.6 bits (179), Expect = 5e-13 Identities = 49/172 (28%), Positives = 84/172 (48%), Gaps = 26/172 (15%) Frame = +1 Query: 199 FRDKLGQGGYGTVYK----------------GVLLPGDVHVAVKMLEENSNCNGE-DFIS 327 F++KLG+G +G V+ V V VAVKML ++N N DF+ Sbjct: 565 FKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLK 624 Query: 328 EVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAE---------KSFSW 480 E+ + R+ NI+ L+ C + ++ EYM NG +++++ E ++ S+ Sbjct: 625 EIKIMSRLKDPNIIHLLSVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSY 684 Query: 481 DKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 L +A IA G+ YL + +H D+ N L+ N+ K+ADFG+++ Sbjct: 685 TNLKFMATQIASGMKYL---SSLNFVHRDLATRNCLVGKNYTIKIADFGMSR 733
>PCTK3_HUMAN (Q07002) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 73.2 bits (178), Expect = 6e-13 Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 4/148 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKML----EENSNCNGEDFISEVSTIGRIHHVNIVC 372 DKLG+G Y TV+KG + VA+K + EE + C I EVS + + H NIV Sbjct: 146 DKLGEGTYATVFKGRSKLMENLVALKEIRLEHEEGAPCTA---IREVSLLKNLKHANIVT 202 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L + LV+EY+ + + +Y+ S + + RG+ Y H + Sbjct: 203 LHDLIHTDRSLTLVFEYL-DSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHH---RK 258 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAK 636 ILH D+KP N+L++ K+ADFGLA+ Sbjct: 259 ILHRDLKPQNLLINERGELKLADFGLAR 286
>ROR1_HUMAN (Q01973) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) Length = 937 Score = 73.2 bits (178), Expect = 6e-13 Identities = 49/167 (29%), Positives = 83/167 (49%), Gaps = 21/167 (12%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVL-LPGDVH---VAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 F ++LG+ +G +YKG L LPG H VA+K L++ +N +F E S + +HH N Sbjct: 475 FMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWMEFQQEASLMAELHHPN 534 Query: 364 IVCLVGFCSEEMRRALVYEYMPNGSMDKYIF----------------SAEKSFSWDKLNE 495 IVCL+G ++E +++EY+ G + +++ + + S Sbjct: 535 IVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLH 594 Query: 496 IALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 IA+ IA G+ YL +H D+ NIL+ K++D GL++ Sbjct: 595 IAIQIAAGMEYLSSHF---FVHKDLAARNILIGEQLHVKISDLGLSR 638
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 73.2 bits (178), Expect = 6e-13 Identities = 48/147 (32%), Positives = 77/147 (52%), Gaps = 4/147 (2%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGED---FISEVSTIGRIHHVNIV 369 F + +G G +G VYKG + VA+K N+ C+ D F EVS + +++H +V Sbjct: 463 FHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVV 520 Query: 370 CLVGFCSEEMRR-ALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCD 546 VG C ++ + A+V +Y+ GS+ + ++ IA+ +A+G+ YLH Sbjct: 521 QFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHS-LT 579 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFG 627 I+H D+ HNILL + VADFG Sbjct: 580 QPIIHRDLNSHNILLYEDGHAVVADFG 606
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 73.2 bits (178), Expect = 6e-13 Identities = 45/143 (31%), Positives = 75/143 (52%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 +LG G +G V G G VAVKM++E + + ++F E T+ ++ H +V G C Sbjct: 398 ELGNGQFGVVQLGQW-KGQYDVAVKMIKEGA-MSEDEFFQEAQTMMKLSHPKLVKFYGVC 455 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFD 567 S++ +V EY+ NG + Y+ S K +L E+ + G+ +L Q +H D Sbjct: 456 SKKYPIYIVTEYITNGCLLNYLKSHGKGLESCQLLEMCYDVCEGMAFLE---SHQFIHRD 512 Query: 568 IKPHNILLDSNFIPKVADFGLAK 636 + N L+DS+ KV+DFG+ + Sbjct: 513 LAARNCLVDSDLSVKVSDFGMTR 535
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 73.2 bits (178), Expect = 6e-13 Identities = 48/147 (32%), Positives = 77/147 (52%), Gaps = 4/147 (2%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGED---FISEVSTIGRIHHVNIV 369 F + +G G +G VYKG + VA+K N+ C+ D F EVS + +++H +V Sbjct: 464 FHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVV 521 Query: 370 CLVGFCSEEMRR-ALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCD 546 VG C ++ + A+V +Y+ GS+ + ++ IA+ +A+G+ YLH Sbjct: 522 QFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHS-LT 580 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFG 627 I+H D+ HNILL + VADFG Sbjct: 581 QPIIHRDLNSHNILLYEDGHAVVADFG 607
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 72.8 bits (177), Expect = 8e-13 Identities = 46/148 (31%), Positives = 86/148 (58%), Gaps = 3/148 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGF 384 +++G+G +G+V++ VA KML+ +S E F+ E + ++ H IV L+G Sbjct: 224 NEIGRGFFGSVHRAKW-GRSYEVAAKMLQ-SSKAEREKFVLEAKIMHKLRHRKIVELLGV 281 Query: 385 CSE--EMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQI 555 C+E +M ++ EYM NGS+ +Y+ + + K + +++ + I+ G+ YL ++ Sbjct: 282 CTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEISEGMAYLESE---KV 338 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAKL 639 +H D++ NIL+ ++ KVADFGL +L Sbjct: 339 VHRDLRADNILVANDLTRKVADFGLTEL 366
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/152 (32%), Positives = 78/152 (51%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLE-ENSNCNGEDFISEVSTIGRIHHVNIVCLVG 381 +KLG G Y TVYKG+ V+VA+K ++ ++ I E+S + + H NIV L Sbjct: 10 EKLGNGTYATVYKGLNKSTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHDNIVRLYD 69 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFS-----AEKSFSWDKLNEIALGIARGINYLHQGCD 546 E + LV+EYM N + KY+ S A + + + + G+ + H+ Sbjct: 70 VIHTENKLTLVFEYMDN-DLKKYMDSRTVGNAPRGLEMNLVKYFQWQLLEGLAFCHEN-- 126 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 +ILH D+KP N+L+ K+ DFGLA+ + Sbjct: 127 -KILHRDLKPQNLLITKRGQLKLGDFGLARAF 157
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 72.8 bits (177), Expect = 8e-13 Identities = 46/148 (31%), Positives = 80/148 (54%), Gaps = 5/148 (3%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGD----VHVAVKMLEENSNCNGE-DFISEVSTIGRIHHVNIVCL 375 LG G +GTVYKG+ +P + VA+K+L E + +F+ E + + H ++V L Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRL 783 Query: 376 VGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQI 555 +G C + LV + MP+G + +Y+ + + L + IA+G+ YL + ++ Sbjct: 784 LGVCLSPTIQ-LVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEE---RRL 839 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAKL 639 +H D+ N+L+ S K+ DFGLA+L Sbjct: 840 VHRDLAARNVLVKSPNHVKITDFGLARL 867
>CDC2_CAEEL (P34556) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 332 Score = 72.4 bits (176), Expect = 1e-12 Identities = 44/148 (29%), Positives = 79/148 (53%), Gaps = 4/148 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG + VA+K + S G + E+S + + H N+V L Sbjct: 26 EKIGEGTYGVVYKGKNRRTNAMVAMKKIRLESEDEGVPSTAVREISLLKELQHPNVVGLE 85 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYI--FSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 +E R L++E++ + + +Y+ ++ + L I + + + HQ + Sbjct: 86 AVIMQENRLFLIFEFL-SFDLKRYMDQLGKDEYLPLETLKSYTFQILQAMCFCHQ---RR 141 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAK 636 ++H D+KP N+L+D+N K+ADFGLA+ Sbjct: 142 VIHRDLKPQNLLVDNNGAIKLADFGLAR 169
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/147 (34%), Positives = 79/147 (53%), Gaps = 3/147 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGE---DFISEVSTIGRIHHVNIVCL 375 +++G GG VYK + + HVAVK+L+ + E F E S RI + NIV + Sbjct: 14 EEIGVGGTAVVYKAMDTLLNRHVAVKVLKHEFTEDEEFVFKFKREASAAARIANANIVNI 73 Query: 376 VGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQI 555 ++ +V EY+ ++ K I K ++K+ + A IA+ +N+ H+ I Sbjct: 74 YDVGADGNVNYIVMEYVAGKTLKKLIKENGK-IEFNKIIDYATQIAKALNFAHKN---GI 129 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAK 636 +H DIKPHNI++ + I KV DFG+AK Sbjct: 130 VHRDIKPHNIMVTDDDIIKVTDFGIAK 156
>CRK1_LEIME (Q06309) Cell division protein kinase 2 homolog CRK1 (EC 2.7.11.23)| Length = 301 Score = 72.4 bits (176), Expect = 1e-12 Identities = 45/149 (30%), Positives = 74/149 (49%), Gaps = 2/149 (1%) Frame = +1 Query: 202 RDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDF--ISEVSTIGRIHHVNIVCL 375 ++K+G+G YG VYK VA+K + +S G I E+S + + H NIV L Sbjct: 8 QEKIGEGTYGVVYKARDTSTAATVALKRIRLDSEEEGVPCTAIREISLLKELRHENIVKL 67 Query: 376 VGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQI 555 + C E R +V+EY+ + + KY+ + + + RG+ + HQ + Sbjct: 68 LDVCHSEHRLTIVFEYL-DLDLKKYLDRENGNLDAATIQHFMRDLLRGVAFCHQ---RSV 123 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAKLY 642 LH D+KP N+L+ K+ DFGL + + Sbjct: 124 LHRDLKPQNLLISREKELKLGDFGLGRSF 152
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 72.4 bits (176), Expect = 1e-12 Identities = 43/142 (30%), Positives = 77/142 (54%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 ++G G +GTV++G GDV V V + + + + F +E+ + + HVNI+ +GF Sbjct: 315 RIGTGSFGTVFRG-RWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFM 373 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFD 567 + A++ ++ S+ ++ A+ F +L ++A A+G++YLH I+H D Sbjct: 374 TRP-GFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHA---KNIIHRD 429 Query: 568 IKPHNILLDSNFIPKVADFGLA 633 +K +NI L K+ DFGLA Sbjct: 430 LKSNNIFLHEGLTVKIGDFGLA 451
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 72.4 bits (176), Expect = 1e-12 Identities = 47/147 (31%), Positives = 77/147 (52%), Gaps = 4/147 (2%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGED---FISEVSTIGRIHHVNIV 369 F + +G G +G VYKG + VA+K N+ C+ D F EVS + +++H ++ Sbjct: 566 FHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVI 623 Query: 370 CLVGFC-SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCD 546 VG C ++ + A+V +Y+ GS+ + ++ IA+ +A+G+ YLH Sbjct: 624 QFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHN-LT 682 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFG 627 I+H D+ HNILL + VADFG Sbjct: 683 QPIIHRDLNSHNILLYEDGHAVVADFG 709
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 72.4 bits (176), Expect = 1e-12 Identities = 54/154 (35%), Positives = 79/154 (51%), Gaps = 12/154 (7%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKML----EENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G GG+G VY+ + GD VAVK +E+ + E+ E + H NI+ L Sbjct: 150 IGIGGFGKVYRAFWI-GD-EVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 207 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G C +E LV E+ G +++ + + K D L A+ IARG+NYLH + I+ Sbjct: 208 GVCLKEPNLCLVMEFARGGPLNRVL--SGKRIPPDILVNWAVQIARGMNYLHDEAIVPII 265 Query: 559 HFDIKPHNILL--------DSNFIPKVADFGLAK 636 H D+K NIL+ SN I K+ DFGLA+ Sbjct: 266 HRDLKSSNILILQKVENGDLSNKILKITDFGLAR 299
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 72.4 bits (176), Expect = 1e-12 Identities = 45/145 (31%), Positives = 81/145 (55%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLG+G +G V++G+ L G + VA+K+++ ++N D E+ T+ + H ++ L C Sbjct: 235 KLGEGYFGEVWEGLWL-GSLPVAIKVIK-SANMKLTDLAKEIQTLKGLRHERLIRLHAVC 292 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 S +V E M G++ ++ + E ++ L A +A G++YL + +++H Sbjct: 293 SGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEE---QRVVHR 349 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D+ N+L+D KVADFGLA+L Sbjct: 350 DLAARNVLVDDGLACKVADFGLARL 374
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/146 (34%), Positives = 76/146 (52%), Gaps = 2/146 (1%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGE--DFISEVSTIGRIHHVNIVCLV 378 +K+G GG+G VYK + +A+K + E + + E + I+ + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G C E + LV EYM GS++K + A + WD I A G+N+LH +L Sbjct: 86 GICREPV--GLVMEYMETGSLEKLL--ASEPLPWDLRFRIIHETAVGMNFLHCMAP-PLL 140 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+KP NILLD+++ K++DFGLAK Sbjct: 141 HLDLKPANILLDAHYHVKISDFGLAK 166
>PCTK2_RAT (O35831) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 4/148 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKML----EENSNCNGEDFISEVSTIGRIHHVNIVC 372 +KLG+G Y TVYKG + VA+K + EE + C I EVS + + H NIV Sbjct: 196 EKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTA---IREVSLLKDLKHANIVT 252 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L + LV+EY+ + +Y+ S + I RG+ Y H+ + Sbjct: 253 LHDIVHTDKSLTLVFEYLDK-DLKQYMDDCGSIMSMHNVKLFLYQILRGLAYCHR---RK 308 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAK 636 +LH D+KP N+L++ K+ADFGLA+ Sbjct: 309 VLHRDLKPQNLLINERGELKLADFGLAR 336
>PCTK2_MOUSE (Q8K0D0) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 4/148 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKML----EENSNCNGEDFISEVSTIGRIHHVNIVC 372 +KLG+G Y TVYKG + VA+K + EE + C I EVS + + H NIV Sbjct: 196 EKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTA---IREVSLLKDLKHANIVT 252 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L + LV+EY+ + +Y+ S + I RG+ Y H+ + Sbjct: 253 LHDIVHTDKSLTLVFEYLDK-DLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHR---RK 308 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAK 636 +LH D+KP N+L++ K+ADFGLA+ Sbjct: 309 VLHRDLKPQNLLINERGELKLADFGLAR 336
>PCTK2_HUMAN (Q00537) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 72.4 bits (176), Expect = 1e-12 Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 4/148 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKML----EENSNCNGEDFISEVSTIGRIHHVNIVC 372 +KLG+G Y TVYKG + VA+K + EE + C I EVS + + H NIV Sbjct: 196 EKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTA---IREVSLLKDLKHANIVT 252 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L + LV+EY+ + +Y+ S + I RG+ Y H+ + Sbjct: 253 LHDIVHTDKSLTLVFEYLDK-DLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHR---RK 308 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAK 636 +LH D+KP N+L++ K+ADFGLA+ Sbjct: 309 VLHRDLKPQNLLINEKGELKLADFGLAR 336
>CDC2_CARAU (P51958) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 302 Score = 72.4 bits (176), Expect = 1e-12 Identities = 51/152 (33%), Positives = 80/152 (52%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG VA+K + S G + E+S + + H N+V L+ Sbjct: 8 EKIGEGTYGVVYKGRNKTTGQVVAMKKIRLESEEEGVPSTAVREISLLKELQHPNVVRLL 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDKL--NEIALGIARGINYLHQGCD 546 +E + LV+E++ SMD KY+ S D + I GI + H C Sbjct: 68 DVLMQESKLYLVFEFL---SMDLKKYLDSIPSGQFMDPMLVKSYLYQILEGILFCH--C- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+D+ + K+ADFGLA+ + Sbjct: 122 RRVLHRDLKPQNLLIDNKGVIKLADFGLARAF 153
>CC2H3_TRYBB (P54666) Cell division control protein 2 homolog 3 (EC 2.7.11.22)| Length = 311 Score = 72.4 bits (176), Expect = 1e-12 Identities = 47/148 (31%), Positives = 81/148 (54%), Gaps = 2/148 (1%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 D LG+G YG VY+ V VA+K + + G + + EVS + IHH NIV L+ Sbjct: 27 DILGEGTYGVVYRAVDRATGQIVALKKVRLDRTDEGIPQTALREVSILQEIHHPNIVNLL 86 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 + + L++EY+ + + K + +F+ L +I + G+++ H+ +I+ Sbjct: 87 DVICADGKLYLIFEYVDH-DLKKALEKRGGAFTGTTLKKIIYQLLEGLSFCHRH---RIV 142 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKLY 642 H D+KP NIL+ ++ K+ADFGLA+ + Sbjct: 143 HRDLKPANILVTTDNSVKIADFGLARAF 170
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 72.0 bits (175), Expect = 1e-12 Identities = 43/142 (30%), Positives = 77/142 (54%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 ++G G +GTV++G GDV V V + + + + F +E+ + + HVNI+ +GF Sbjct: 313 RIGTGSFGTVFRG-RWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFM 371 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFD 567 + A++ ++ S+ ++ A+ F +L ++A A+G++YLH I+H D Sbjct: 372 TRP-GFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHA---KNIIHRD 427 Query: 568 IKPHNILLDSNFIPKVADFGLA 633 +K +NI L K+ DFGLA Sbjct: 428 LKSNNIFLHEGLTVKIGDFGLA 449
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 72.0 bits (175), Expect = 1e-12 Identities = 43/142 (30%), Positives = 77/142 (54%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 ++G G +GTV++G GDV V V + + + + F +E+ + + HVNI+ +GF Sbjct: 313 RIGTGSFGTVFRG-RWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFM 371 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFD 567 + A++ ++ S+ ++ A+ F +L ++A A+G++YLH I+H D Sbjct: 372 TRP-GFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHA---KNIIHRD 427 Query: 568 IKPHNILLDSNFIPKVADFGLA 633 +K +NI L K+ DFGLA Sbjct: 428 LKSNNIFLHEGLTVKIGDFGLA 449
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 72.0 bits (175), Expect = 1e-12 Identities = 53/156 (33%), Positives = 76/156 (48%), Gaps = 2/156 (1%) Frame = +1 Query: 166 AYTDIIAITRHFRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIG 345 AY D IT R+K+G G YG V K V D VAVK E ++ +D EV + Sbjct: 12 AYVDFSEIT--LREKVGHGSYGVVCKAVWR--DKLVAVK--EFFASAEQKDIEKEVKQLS 65 Query: 346 RIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEK-SFSWDKLNEIALGIARGI 522 R+ H NI+ L G S + L+ E+ GS+ ++ K ++S A A G+ Sbjct: 66 RVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGL 125 Query: 523 NYLHQGCDMQILHFDIKPHNILL-DSNFIPKVADFG 627 YLH ++H D+KP N+LL + K+ DFG Sbjct: 126 AYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFG 161
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 72.0 bits (175), Expect = 1e-12 Identities = 43/142 (30%), Positives = 77/142 (54%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 ++G G +GTV++G GDV V V + + + + F +E+ + + HVNI+ +GF Sbjct: 315 RIGTGSFGTVFRG-RWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFM 373 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFD 567 + A++ ++ S+ ++ A+ F +L ++A A+G++YLH I+H D Sbjct: 374 TRP-GFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHA---KNIIHRD 429 Query: 568 IKPHNILLDSNFIPKVADFGLA 633 +K +NI L K+ DFGLA Sbjct: 430 LKSNNIFLHEGLTVKIGDFGLA 451
>PCTK3_RAT (O35832) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 72.0 bits (175), Expect = 1e-12 Identities = 49/148 (33%), Positives = 76/148 (51%), Gaps = 4/148 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKML----EENSNCNGEDFISEVSTIGRIHHVNIVC 372 DKLG+G Y TV+KG + VA+K + EE + C I EVS + + H NIV Sbjct: 125 DKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTA---IREVSLLKDLKHANIVT 181 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L + LV+EY+ + + +Y+ + + + RG+ Y H+ + Sbjct: 182 LHDLIHTDRSLTLVFEYL-DSDLKQYLDHCGNLMNMHNVKIFMFQLLRGLAYCHR---RK 237 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAK 636 ILH D+KP N+L++ K+ADFGLA+ Sbjct: 238 ILHRDLKPQNLLINERGELKLADFGLAR 265
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 72.0 bits (175), Expect = 1e-12 Identities = 44/142 (30%), Positives = 76/142 (53%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 ++G G +GTVY+ G V V ++ S + F +EV+ + + H NI+ +G C Sbjct: 434 RIGSGSFGTVYRAHW-HGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG-C 491 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFD 567 + A+V ++ S+ K++ +E F + L +I +A+G++YLH I+H D Sbjct: 492 VSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHA---KNIIHRD 548 Query: 568 IKPHNILLDSNFIPKVADFGLA 633 +K +NI L + K+ DFGLA Sbjct: 549 LKSNNIFLHEDLSVKIGDFGLA 570
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 72.0 bits (175), Expect = 1e-12 Identities = 51/146 (34%), Positives = 77/146 (52%), Gaps = 2/146 (1%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLG G +G V+ GV VAVK L+ + + F+ E + ++ H ++V L C Sbjct: 245 KLGAGQFGEVWAGVW-NNTTQVAVKTLKPGT-MSPASFLDEAGVMKKLRHKHLVQLYAIC 302 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEK-SFSWDKLNEIALGIARGINYLH-QGCDMQILH 561 S+ +V EYM GS+ Y+ E + L ++A +A G+ +L QG +H Sbjct: 303 SDREPIYIVTEYMSGGSLLDYLSKGEGVNLQLPTLIDMAAQVASGMAFLEAQG----YIH 358 Query: 562 FDIKPHNILLDSNFIPKVADFGLAKL 639 D+ NIL+ N+I KVADFGLA+L Sbjct: 359 RDLAARNILVGENYICKVADFGLARL 384
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 71.6 bits (174), Expect = 2e-12 Identities = 52/145 (35%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLGQG +G V+ G G VA+K L+ + + E F+ E + ++ H +V L Sbjct: 268 KLGQGYFGEVWMGTW-NGTTRVAIKTLKPGT-MSPEAFLQEAQVMKKLRHEKLVQLYAMV 325 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V EYM GS+ ++ K +L E+A IA G+ Y+ + M +H Sbjct: 326 SEEPIY-IVIEYMSKGSLLDFLKGEMGKYLRLPQLVEMAAQIASGMAYVER---MNYVHR 381 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + KVADFGLA+L Sbjct: 382 DLRAANILVGENLVCKVADFGLARL 406
>PCTK3_MOUSE (Q04899) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 71.6 bits (174), Expect = 2e-12 Identities = 49/148 (33%), Positives = 75/148 (50%), Gaps = 4/148 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKML----EENSNCNGEDFISEVSTIGRIHHVNIVC 372 DKLG+G Y TV+KG + VA+K + EE + C I EVS + + H NIV Sbjct: 125 DKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTA---IREVSLLKDLKHANIVT 181 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L + LV+EY+ + + +Y+ + + + RG+ Y H + Sbjct: 182 LHDLIHTDRSLTLVFEYL-DSDLKQYLDHCGNLMNMHNVKIFMFQLLRGLAYCHH---RK 237 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAK 636 ILH D+KP N+L++ K+ADFGLA+ Sbjct: 238 ILHRDLKPQNLLINERGELKLADFGLAR 265
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 71.6 bits (174), Expect = 2e-12 Identities = 46/152 (30%), Positives = 81/152 (53%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLE-ENSNCNGEDFISEVSTIGRIHHVNIVCLVG 381 +K+G G Y TVYKG+ V+VA+K ++ ++ I E+S + + H NIV L Sbjct: 11 EKVGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHDNIVRLFD 70 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFS-----AEKSFSWDKLNEIALGIARGINYLHQGCD 546 E + LV+E+M N + K++ + + K D + + +G+ + H+ Sbjct: 71 VIHTENKLTLVFEFMDN-DLKKFMDNRNKGNSHKGLEMDLVKYFQWQLLQGVAFCHEN-- 127 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 +ILH D+KP N+L+++ K+ DFGLA+ + Sbjct: 128 -RILHRDLKPQNLLINNRGQLKLGDFGLARAF 158
>EGFR_DROME (P04412) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Egfr) (Gurken receptor) (Protein torpedo) (Drosophila relative of ERBB) Length = 1426 Score = 71.6 bits (174), Expect = 2e-12 Identities = 45/148 (30%), Positives = 79/148 (53%), Gaps = 5/148 (3%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGD----VHVAVKMLEENSNC-NGEDFISEVSTIGRIHHVNIVCL 375 LG G +G VYKGV +P + VA+K L +++ + E+F+ E + HVN++ L Sbjct: 944 LGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKL 1003 Query: 376 VGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQI 555 + C + L+ + MP G + Y+ + L + IA+G++YL + ++ Sbjct: 1004 LAVCMSS-QMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEE---KRL 1059 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAKL 639 +H D+ N+L+ + + K+ DFGLAKL Sbjct: 1060 VHRDLAARNVLVQTPSLVKITDFGLAKL 1087
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 71.2 bits (173), Expect = 2e-12 Identities = 51/152 (33%), Positives = 77/152 (50%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG VA+K + S G I E+S + + H NIV L Sbjct: 8 EKIGEGTYGVVYKGRHRTTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDK--LNEIALGIARGINYLHQGCD 546 ++ R L++E++ SMD KY+ S D + I +GI + H Sbjct: 68 DVLMQDSRLYLIFEFL---SMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHS--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+D K+ADFGLA+ + Sbjct: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF 153
>CDC2_HUMAN (P06493) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 71.2 bits (173), Expect = 2e-12 Identities = 51/152 (33%), Positives = 77/152 (50%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG VA+K + S G I E+S + + H NIV L Sbjct: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDK--LNEIALGIARGINYLHQGCD 546 ++ R L++E++ SMD KY+ S D + I +GI + H Sbjct: 68 DVLMQDSRLYLIFEFL---SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+D K+ADFGLA+ + Sbjct: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF 153
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 71.2 bits (173), Expect = 2e-12 Identities = 51/152 (33%), Positives = 77/152 (50%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG VA+K + S G I E+S + + H NIV L Sbjct: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDK--LNEIALGIARGINYLHQGCD 546 ++ R L++E++ SMD KY+ S D + I +GI + H Sbjct: 68 DVLMQDSRLYLIFEFL---SMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHS--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+D K+ADFGLA+ + Sbjct: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF 153
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 70.9 bits (172), Expect = 3e-12 Identities = 46/149 (30%), Positives = 75/149 (50%), Gaps = 3/149 (2%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLE-ENSNCNGEDFISEVSTIGRIHHVNIVCLVG 381 +KLG+G Y TVYKG VA+K + ++ I E+S + + H NIV L Sbjct: 12 EKLGEGTYATVYKGRNRATGALVALKEISLDSEEGTPSTAIREISLMKELDHENIVTLYD 71 Query: 382 FCSEEMRRALVYEYMPNGSMDKY--IFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQI 555 E + LV+EYM + KY + + + + + +GI + H D ++ Sbjct: 72 VIHTENKLTLVFEYMDK-DLKKYMEVHGQQSALDLKVVKSFMFQLLKGIMFCH---DNRV 127 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAKLY 642 LH D+KP N+L+++ K+ DFGLA+ + Sbjct: 128 LHRDLKPQNLLINNKGELKLGDFGLARAF 156
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 70.9 bits (172), Expect = 3e-12 Identities = 43/146 (29%), Positives = 73/146 (50%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 F +LG G +G V G VA+K + E + C EDFI E + ++ H +V L Sbjct: 371 FMRELGSGLFGVVRLGKWR-AQYKVAIKAIREGAMCE-EDFIEEAKVMMKLTHPKLVQLY 428 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G C+++ +V E+M G + ++ + FS D L + + G+ YL + + Sbjct: 429 GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDMLLSMCQDVCEGMEYLERN---SFI 485 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ N L++ + KV+DFG+A+ Sbjct: 486 HRDLAARNCLVNEAGVVKVSDFGMAR 511
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 70.9 bits (172), Expect = 3e-12 Identities = 51/160 (31%), Positives = 79/160 (49%), Gaps = 14/160 (8%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLE-ENSNCNGEDFISEVSTIGRIHHVNIVCLVG 381 +KLG G Y TVYKG+ V+VA+K ++ ++ I E+S + + H NIV L Sbjct: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAE-------------KSFSWDKLNEIALGIARGI 522 E + LV+E+M N + KY+ S K F W L +G+ Sbjct: 71 VIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLL--------QGL 121 Query: 523 NYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 + H+ +ILH D+KP N+L++ K+ DFGLA+ + Sbjct: 122 AFCHEN---KILHRDLKPQNLLINKRGQLKLGDFGLARAF 158
>CDK7_XENLA (P20911) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (40 kDa protein kinase) (P40 MO15) (CDC2/CDK2,4-activating kinase) Length = 352 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/151 (31%), Positives = 76/151 (50%), Gaps = 5/151 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFIS-----EVSTIGRIHHVNIV 369 D LG+G + TVYK D VA+K ++ D I+ E+ + + H NI+ Sbjct: 22 DFLGEGQFATVYKARDKNTDRIVAIKKIKLGHRAEANDGINRTALREIKLLQELSHPNII 81 Query: 370 CLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDM 549 L+ + +LV+++M ++ I + + L +G+ YLH + Sbjct: 82 GLLDAFGHKSNISLVFDFMET-DLEVIIKDTSLVLTPAHIKSYMLMTLQGLEYLHH---L 137 Query: 550 QILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ILH D+KP+N+LLD N + K+ADFGLAK + Sbjct: 138 WILHRDLKPNNLLLDENGVLKLADFGLAKSF 168
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 70.9 bits (172), Expect = 3e-12 Identities = 43/148 (29%), Positives = 73/148 (49%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 F +LG G +G V G VA+K + E + C EDFI E + ++ H +V L Sbjct: 372 FMRELGSGLFGVVRLGKWR-AQYKVAIKAIREGAMCE-EDFIEEAKVMMKLTHPKLVQLY 429 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G C+++ +V E+M G + ++ + FS D L + + G+ YL + + Sbjct: 430 GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERN---SFI 486 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKLY 642 H D+ N L+ + KV+DFG+A+ + Sbjct: 487 HRDLAARNCLVSEAGVVKVSDFGMARYF 514
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 70.9 bits (172), Expect = 3e-12 Identities = 48/145 (33%), Positives = 80/145 (55%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 +LG G +G V+ G G+ VA+K L+ + + E F+ E + ++ H +V L Sbjct: 275 RLGNGQFGEVWMGTW-NGNTKVAIKTLKPGT-MSPESFLEEAQIMKKLKHDKLVQLYAVV 332 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V EYM GS+ ++ E ++ L ++A +ARG+ Y+ + M +H Sbjct: 333 SEEPIY-IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVARGMAYIER---MNYIHR 388 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ + I K+ADFGLA+L Sbjct: 389 DLRSANILVGNGLICKIADFGLARL 413
>XMRK_XIPMA (P13388) Melanoma receptor tyrosine-protein kinase precursor (EC| 2.7.10.1) Length = 1167 Score = 70.9 bits (172), Expect = 3e-12 Identities = 49/164 (29%), Positives = 85/164 (51%), Gaps = 6/164 (3%) Frame = +1 Query: 166 AYTDIIAITRHFRDK-LGQGGYGTVYKGVLLPGD----VHVAVKMLEENSNCN-GEDFIS 327 A+ I+ T +D+ LG G +GTVYKG+ P + VA+K+L E ++ ++ + Sbjct: 700 AFLRILKETEFKKDRVLGSGAFGTVYKGLWNPDGENIRIPVAIKVLREATSPKVNQEVLD 759 Query: 328 EVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALG 507 E + + H ++ L+G C + LV + MP G + Y+ ++ L + Sbjct: 760 EAYVMASVDHPHVCRLLGICLTSAVQ-LVTQLMPYGCLLDYVRQHQERICGQWLLNWCVQ 818 Query: 508 IARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 IA+G+NYL + ++H D+ N+LL + K+ DFGL+KL Sbjct: 819 IAKGMNYLEE---RHLVHRDLAARNVLLKNPNHVKITDFGLSKL 859
>RON_MOUSE (Q62190) Macrophage-stimulating protein receptor precursor (EC| 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating prote Length = 1378 Score = 70.9 bits (172), Expect = 3e-12 Identities = 49/153 (32%), Positives = 78/153 (50%), Gaps = 6/153 (3%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPG---DVHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVN 363 H +G+G +G VY G G H A+K L + E F+ E + +HH N Sbjct: 1060 HTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIKSLSRITEVQEVEAFLREGLLMRGLHHPN 1119 Query: 364 IVCLVGFC--SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQ 537 I+ L+G E + R L+ YM +G + ++I S +++ + L L +A G+ YL Sbjct: 1120 ILALIGIMLPPEGLPRVLL-PYMRHGDLLRFIRSPQRNPTVKDLVSFGLQVACGMEYL-- 1176 Query: 538 GCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 + + +H D+ N +LD +F KVADFGLA+ Sbjct: 1177 -AEQKFVHRDLAARNCMLDESFTVKVADFGLAR 1208
>PFTK1_MOUSE (O35495) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 70.9 bits (172), Expect = 3e-12 Identities = 49/146 (33%), Positives = 73/146 (50%), Gaps = 2/146 (1%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDF--ISEVSTIGRIHHVNIVCLV 378 +KLG+G Y TVYKG VA+K++ G F I E S + + H NIV L Sbjct: 139 EKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANIVLLH 197 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 + LV+EY+ + + +Y+ D + + RG++Y+HQ IL Sbjct: 198 DIIHTKETLTLVFEYV-HTDLCQYMEQHPGGLHPDNVKLFLFQLLRGLSYIHQ---RYIL 253 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+KP N+L+ K+ADFGLA+ Sbjct: 254 HRDLKPQNLLISDTGELKLADFGLAR 279
>PFTK1_HUMAN (O94921) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 70.9 bits (172), Expect = 3e-12 Identities = 49/146 (33%), Positives = 73/146 (50%), Gaps = 2/146 (1%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDF--ISEVSTIGRIHHVNIVCLV 378 +KLG+G Y TVYKG VA+K++ G F I E S + + H NIV L Sbjct: 139 EKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANIVLLH 197 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 + LV+EY+ + + +Y+ D + + RG++Y+HQ IL Sbjct: 198 DIIHTKETLTLVFEYV-HTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ---RYIL 253 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+KP N+L+ K+ADFGLA+ Sbjct: 254 HRDLKPQNLLISDTGELKLADFGLAR 279
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 70.5 bits (171), Expect = 4e-12 Identities = 47/149 (31%), Positives = 75/149 (50%), Gaps = 7/149 (4%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGED-----FISEVSTIGRIHHVNIVCL 375 LG+G YGTVY G+ G + ++ + SN + EV + + HVNIV Sbjct: 1067 LGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAY 1126 Query: 376 VGFCSEEMRRALVYEYMPNGSMDKYI--FSAEKSFSWDKLNEIALGIARGINYLHQGCDM 549 +G C +E ++ E++P GS+ I F + K + I +G+ YLH+ C Sbjct: 1127 LGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTK---QILQGVAYLHENC-- 1181 Query: 550 QILHFDIKPHNILLDSNFIPKVADFGLAK 636 ++H DIK +N++L I K+ DFG A+ Sbjct: 1182 -VVHRDIKGNNVMLMPTGIIKLIDFGCAR 1209
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 70.5 bits (171), Expect = 4e-12 Identities = 47/150 (31%), Positives = 78/150 (52%), Gaps = 3/150 (2%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 F KLG G +G V++G L VA+K L+ + + +DF++E + ++ H ++ L Sbjct: 250 FVRKLGSGQFGDVWEG-LWNNTTPVAIKTLKSGT-MDPKDFLAEAQIMKKLRHTKLIQLY 307 Query: 379 GFCSEEMRRALVYEYMPNGSMDKY---IFSAEKSFSWDKLNEIALGIARGINYLHQGCDM 549 C+ E ++ E M +GS+ +Y I +S L ++A IA G+ YL Sbjct: 308 AVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLES---Q 364 Query: 550 QILHFDIKPHNILLDSNFIPKVADFGLAKL 639 +H D+ N+L+ I K+ADFGLA+L Sbjct: 365 NYIHRDLAARNVLVGDGNIVKIADFGLARL 394
>SEA_AVIET (P23049) Tyrosine-protein kinase transforming protein SEA (EC| 2.7.10.2) Length = 370 Score = 70.5 bits (171), Expect = 4e-12 Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 5/147 (3%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLP---GDVHVAVKMLEENSNCNG-EDFISEVSTIGRIHHVNIVCLV 378 +G+G +G+VY G + G++H AVK L + E+F+ E + HH ++ L+ Sbjct: 66 IGRGHFGSVYHGTYMDPLLGNLHCAVKSLHRITYLEEVEEFLREGILMKGFHHPQVLSLL 125 Query: 379 GFCSEEMRRALVY-EYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQI 555 G C LV YM +G + ++ + E+S + +L L +A G+ YL Q + Sbjct: 126 GVCLPRHGLPLVVLPYMRHGDLRHFVRAQERSPTVKELIGFGLQVALGMEYLAQ---KKF 182 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAK 636 +H D+ N +LD KVADFGLA+ Sbjct: 183 VHRDLAARNCMLDETLTVKVADFGLAR 209
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 70.5 bits (171), Expect = 4e-12 Identities = 47/152 (30%), Positives = 73/152 (48%), Gaps = 10/152 (6%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKML--EENSNCNGEDFISEVSTIGRIHHVNIVCLVGF 384 +G GG+G VY+ + +V V L E++ E E G + H NI+ L G Sbjct: 104 IGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGA 163 Query: 385 CSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 C LV EY G++ + + A + L A+ +ARG+NYLH + I+H Sbjct: 164 CLNPPHLCLVMEYARGGALSRVL--AGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHR 221 Query: 565 DIKPHNILL--------DSNFIPKVADFGLAK 636 D+K NIL+ ++ + K+ DFGLA+ Sbjct: 222 DLKSINILILEAIENHNLADTVLKITDFGLAR 253
>CDC2H_PLAFK (Q07785) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (PfPK5) Length = 288 Score = 70.5 bits (171), Expect = 4e-12 Identities = 47/150 (31%), Positives = 72/150 (48%), Gaps = 1/150 (0%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGDVHVAVKM-LEENSNCNGEDFISEVSTIGRIHHVNIVC 372 H +K+G+G YG VYK G+ K+ LE+ I E+S + + H NIV Sbjct: 5 HGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVK 64 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L + R LV+E++ + K + E L + GI Y H D + Sbjct: 65 LYDVIHTKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCH---DRR 120 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 +LH D+KP N+L++ K+ADFGLA+ + Sbjct: 121 VLHRDLKPQNLLINREGELKIADFGLARAF 150
>CDC2H_PLAF7 (P61075) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 70.5 bits (171), Expect = 4e-12 Identities = 47/150 (31%), Positives = 72/150 (48%), Gaps = 1/150 (0%) Frame = +1 Query: 196 HFRDKLGQGGYGTVYKGVLLPGDVHVAVKM-LEENSNCNGEDFISEVSTIGRIHHVNIVC 372 H +K+G+G YG VYK G+ K+ LE+ I E+S + + H NIV Sbjct: 5 HGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVK 64 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L + R LV+E++ + K + E L + GI Y H D + Sbjct: 65 LYDVIHTKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCH---DRR 120 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 +LH D+KP N+L++ K+ADFGLA+ + Sbjct: 121 VLHRDLKPQNLLINREGELKIADFGLARAF 150
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 70.1 bits (170), Expect = 5e-12 Identities = 43/146 (29%), Positives = 73/146 (50%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 F ++G G +G V+ G + VA+K + E S + EDFI E + ++ H +V L Sbjct: 273 FVKEIGSGQFGVVHLGEWR-AHIPVAIKAINEGS-MSEEDFIEEAKVMMKLSHSRLVQLY 330 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G C ++ +V E+M NG + Y+ + L + I G+ YL + C + Sbjct: 331 GVCIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMAYLERSC---YI 387 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ N L+ S + K++DFG+A+ Sbjct: 388 HRDLAARNCLVSSACVVKISDFGMAR 413
>CDK4_XENLA (Q91727) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 319 Score = 70.1 bits (170), Expect = 5e-12 Identities = 49/155 (31%), Positives = 76/155 (49%), Gaps = 10/155 (6%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDF--ISEVSTIGRIHHV---NIVC 372 ++G G YGTVYK L VA+K + +N NG + EV+ + R+ H NIV Sbjct: 14 EIGVGAYGTVYKARDLQSGKFVALKNVRVQTNENGLPLSTVREVTLLKRLEHFDHPNIVK 73 Query: 373 LVGFCSE-----EMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQ 537 L+ C+ E + LV+E++ + + ++ G+ +LH Sbjct: 74 LMDVCASARTDRETKVTLVFEHVDQDLKTYLSKVPPPGLPLETIKDLMKQFLSGLEFLHL 133 Query: 538 GCDMQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 C I+H D+KP NIL+ S K+ADFGLA++Y Sbjct: 134 NC---IVHRDLKPENILVTSGGQVKLADFGLARIY 165
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 70.1 bits (170), Expect = 5e-12 Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLGQG +G V+ G G VA+K L+ + + E F+ E + ++ H +V L Sbjct: 274 KLGQGCFGEVWMGTW-NGTTRVAIKTLKPGT-MSPEAFLQEAQVMKKLRHEKLVQLYAVV 331 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V EYM GS+ ++ K +L ++A IA G+ Y+ + M +H Sbjct: 332 SEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER---MNYVHR 387 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + KVADFGLA+L Sbjct: 388 DLRAANILVGENLVCKVADFGLARL 412
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 70.1 bits (170), Expect = 5e-12 Identities = 48/145 (33%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 +LG G +G V+ G G VAVK L+ + + E F+ E + ++ H +V L Sbjct: 275 RLGNGQFGEVWMGTW-NGTTKVAVKTLKPGT-MSPESFLEEAQIMKKLRHDKLVQLYAVV 332 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V EYM GS+ ++ E ++ L ++A +A G+ Y+ + M +H Sbjct: 333 SEEPIY-IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHR 388 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + K+ADFGLA+L Sbjct: 389 DLRSANILVGDNLVCKIADFGLARL 413
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 70.1 bits (170), Expect = 5e-12 Identities = 51/152 (33%), Positives = 77/152 (50%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG VA+K + S G I E+S + + H NIV L Sbjct: 8 EKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDK--LNEIALGIARGINYLHQGCD 546 ++ R L++E++ SMD KY+ S D + I +GI + H Sbjct: 68 DVLMQDSRLYLIFEFL---SMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGIVFCHS--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+D K+ADFGLA+ + Sbjct: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF 153
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 70.1 bits (170), Expect = 5e-12 Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLGQG +G V+ G G VA+K L+ + + E F+ E + ++ H +V L Sbjct: 271 KLGQGCFGEVWMGTW-NGTTRVAIKTLKPGT-MSPEAFLQEAQVMKKLRHKKLVQLYAVV 328 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V EYM GS+ ++ K +L ++A IA G+ Y+ + M +H Sbjct: 329 SEEPIY-IVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHR 384 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + KVADFGLA+L Sbjct: 385 DLRAANILVGENLVCKVADFGLARL 409
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 70.1 bits (170), Expect = 5e-12 Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLGQG +G V+ G G VA+K L+ + + E F+ E + ++ H +V L Sbjct: 271 KLGQGCFGEVWMGTW-NGTTRVAIKTLKPGT-MSPEAFLQEAQVMKKLRHEKLVQLYAVV 328 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V EYM GS+ ++ K +L ++A IA G+ Y+ + M +H Sbjct: 329 SEEPIY-IVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHR 384 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + KVADFGLA+L Sbjct: 385 DLRAANILVGENLVCKVADFGLARL 409
>ERBB3_RAT (Q62799) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) Length = 1339 Score = 70.1 bits (170), Expect = 5e-12 Identities = 54/201 (26%), Positives = 102/201 (50%), Gaps = 14/201 (6%) Frame = +1 Query: 79 AYKYWKTRIIID--AVEKFLRIQQLIGPTRYAYTDIIAITRHFRDK-------LGQGGYG 231 ++ YW+ R I + A+ ++L + I P + + R F++ LG G +G Sbjct: 660 SFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFG 719 Query: 232 TVYKGVLLPGD----VHVAVKMLEENSNCNGEDFISE-VSTIGRIHHVNIVCLVGFCSEE 396 TV+KG+ +P + V +K++E+ S +++ + +G + H +IV L+G C Sbjct: 720 TVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGS 779 Query: 397 MRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFDIKP 576 + LV +Y+P GS+ ++ ++ L + IA+G+ YL + ++H D+ Sbjct: 780 SLQ-LVTQYLPLGSLLDHVKQHRETLGPQLLLNWGVQIAKGMYYLEEH---SMVHRDLAL 835 Query: 577 HNILLDSNFIPKVADFGLAKL 639 N++L S +VADFG+A L Sbjct: 836 RNVMLKSPSQVQVADFGVADL 856
>ERBB3_MOUSE (Q61526) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Glial growth factor receptor) Length = 1339 Score = 70.1 bits (170), Expect = 5e-12 Identities = 54/201 (26%), Positives = 102/201 (50%), Gaps = 14/201 (6%) Frame = +1 Query: 79 AYKYWKTRIIID--AVEKFLRIQQLIGPTRYAYTDIIAITRHFRDK-------LGQGGYG 231 ++ YW+ R I + A+ ++L + I P + + R F++ LG G +G Sbjct: 660 SFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFG 719 Query: 232 TVYKGVLLPGD----VHVAVKMLEENSNCNGEDFISE-VSTIGRIHHVNIVCLVGFCSEE 396 TV+KG+ +P + V +K++E+ S +++ + +G + H +IV L+G C Sbjct: 720 TVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGS 779 Query: 397 MRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFDIKP 576 + LV +Y+P GS+ ++ ++ L + IA+G+ YL + ++H D+ Sbjct: 780 SLQ-LVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEH---SMVHRDLAL 835 Query: 577 HNILLDSNFIPKVADFGLAKL 639 N++L S +VADFG+A L Sbjct: 836 RNVMLKSPSQVQVADFGVADL 856
>CDK5_DROME (P48609) Cell division protein kinase 5 homolog (EC 2.7.11.22)| Length = 294 Score = 69.7 bits (169), Expect = 7e-12 Identities = 45/148 (30%), Positives = 73/148 (49%), Gaps = 2/148 (1%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKM--LEENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YGTV+KG VA+K L+E+ + E+ + + H NIV L+ Sbjct: 8 EKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLI 67 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 + + LV+E+ + KY S L + RG+ + H +L Sbjct: 68 DVLHSDKKLTLVFEHCDQ-DLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSH---NVL 123 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAKLY 642 H D+KP N+L++ N K+ADFGLA+ + Sbjct: 124 HRDLKPQNLLINKNGELKLADFGLARAF 151
>DDR1_MOUSE (Q03146) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protei Length = 911 Score = 69.7 bits (169), Expect = 7e-12 Identities = 48/181 (26%), Positives = 86/181 (47%), Gaps = 35/181 (19%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVL----------LPGDVH------VAVKMLEENSNCNGE-DFIS 327 F++KLG+G +G V+ + P VH VAVK+L ++ N DF+ Sbjct: 610 FKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLK 669 Query: 328 EVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAE-------------- 465 EV + R+ NI+ L+G C ++ ++ +YM NG +++++ + + Sbjct: 670 EVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSARQLENKATQGLSGDTE 729 Query: 466 ----KSFSWDKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLA 633 + S+ L + IA G+ YL + +H D+ N L+ NF K+ADFG++ Sbjct: 730 SDQGPTISYPMLLHVGAQIASGMRYL---ATLNFVHRDLATRNCLVGENFTIKIADFGMS 786 Query: 634 K 636 + Sbjct: 787 R 787
>M3K5_HUMAN (Q99683) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1374 Score = 69.7 bits (169), Expect = 7e-12 Identities = 50/150 (33%), Positives = 76/150 (50%), Gaps = 8/150 (5%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFCS 390 LG+G YG VY G L V +A+K + E + + E++ + H NIV +G S Sbjct: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745 Query: 391 EEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKL--NEIALG-----IARGINYLHQGCDM 549 E + E +P GS+ + S W L NE +G I G+ YLH D Sbjct: 746 ENGFIKIFMEQVPGGSLSALLRS-----KWGPLKDNEQTIGFYTKQILEGLKYLH---DN 797 Query: 550 QILHFDIKPHNILLDS-NFIPKVADFGLAK 636 QI+H DIK N+L+++ + + K++DFG +K Sbjct: 798 QIVHRDIKGDNVLINTYSGVLKISDFGTSK 827
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 69.7 bits (169), Expect = 7e-12 Identities = 41/149 (27%), Positives = 73/149 (48%), Gaps = 1/149 (0%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 F + G G +G+VY+ + D VAVK L + E + + H NI+ Sbjct: 18 FFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEK--------EAEILSVLSHRNIIQFY 69 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFS-AEKSFSWDKLNEIALGIARGINYLHQGCDMQI 555 G E +V EY GS+ YI S + D + A +A+G++YLH +++ Sbjct: 70 GVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKV 129 Query: 556 LHFDIKPHNILLDSNFIPKVADFGLAKLY 642 +H D+K N+++ ++ + K+ DFG ++ + Sbjct: 130 IHRDLKSRNVVIAADGVLKICDFGASRFH 158
>CC2H1_TRYBB (P38973) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 69.7 bits (169), Expect = 7e-12 Identities = 46/150 (30%), Positives = 71/150 (47%), Gaps = 5/150 (3%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKML-----EENSNCNGEDFISEVSTIGRIHHVNIVC 372 K+G+G YG V++ + VAVK + EE C I E+S + + H NIV Sbjct: 10 KIGEGSYGVVFRARDVTTGTIVAVKRIRLEKEEEGVPCTA---IREISILKELRHENIVR 66 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQ 552 L+ C E R LV+E M + KY+ + E + G+ + H+ Sbjct: 67 LLDVCHSEKRLTLVFECMEM-DLKKYMDHVGGDLDAGTIQEFMRSLLSGVRFCHE---RN 122 Query: 553 ILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 +LH D+KP N+L+ K+ADFGL + + Sbjct: 123 VLHRDLKPPNLLISREKELKLADFGLGRAF 152
>M3K5_MOUSE (O35099) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1380 Score = 69.7 bits (169), Expect = 7e-12 Identities = 50/150 (33%), Positives = 76/150 (50%), Gaps = 8/150 (5%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFCS 390 LG+G YG VY G L V +A+K + E + + E++ + H NIV +G S Sbjct: 693 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 752 Query: 391 EEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKL--NEIALG-----IARGINYLHQGCDM 549 E + E +P GS+ + S W L NE +G I G+ YLH D Sbjct: 753 ENGFIKIFMEQVPGGSLSALLRS-----KWGPLKDNEQTIGFYTKQILEGLKYLH---DN 804 Query: 550 QILHFDIKPHNILLDS-NFIPKVADFGLAK 636 QI+H DIK N+L+++ + + K++DFG +K Sbjct: 805 QIVHRDIKGDNVLINTYSGVLKISDFGTSK 834
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 69.7 bits (169), Expect = 7e-12 Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLGQG +G V+ G G VA+K L+ + + E F+ E + ++ H +V L Sbjct: 271 KLGQGCFGEVWMGTW-NGTTRVAIKTLKPGT-MSPEAFLQEAQVMKKLRHEKLVQLYAVV 328 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V EYM GS+ ++ K +L ++A IA G+ Y+ + M +H Sbjct: 329 SEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHR 384 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + KVADFGLA+L Sbjct: 385 DLRAANILVGENLVCKVADFGLARL 409
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 69.7 bits (169), Expect = 7e-12 Identities = 44/143 (30%), Positives = 67/143 (46%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFCS 390 LG+G +G K + +K L F+ EV + + H N++ +G Sbjct: 352 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 411 Query: 391 EEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFDI 570 +E R + EY+ G++ I S + + W + A IA G+ YLH M I+H D+ Sbjct: 412 KEKRLNFITEYIKGGTLRGLIKSMDSHYPWSQRVSFAKDIAAGMAYLH---SMNIIHRDL 468 Query: 571 KPHNILLDSNFIPKVADFGLAKL 639 HN L+ N VADFGLA+L Sbjct: 469 NSHNCLVRENKSVVVADFGLARL 491
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 69.7 bits (169), Expect = 7e-12 Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLGQG +G V+ G G VA+K L+ + E F+ E + ++ H +V L Sbjct: 279 KLGQGCFGEVWMGTW-NGTTKVAIKTLKPGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVV 336 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSF-SWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V E+M GS+ ++ E F +L ++A IA G+ Y+ + M +H Sbjct: 337 SEEPIY-IVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIER---MNYIHR 392 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + K+ADFGLA+L Sbjct: 393 DLRAANILVGDNLVCKIADFGLARL 417
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 69.7 bits (169), Expect = 7e-12 Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLGQG +G V+ G G VA+K L+ + + E F+ E + ++ H +V L Sbjct: 271 KLGQGCFGEVWMGTW-NGTTRVAIKTLKPGT-MSPEAFLQEAQVMKKLRHEKLVQLYAVV 328 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V EYM GS+ ++ K +L ++A IA G+ Y+ + M +H Sbjct: 329 SEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHR 384 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + KVADFGLA+L Sbjct: 385 DLRAANILVGENLVCKVADFGLARL 409
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 69.7 bits (169), Expect = 7e-12 Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLGQG +G V+ G G VA+K L+ + + E F+ E + ++ H +V L Sbjct: 271 KLGQGCFGEVWMGTW-NGTTRVAIKTLKPGT-MSPEAFLQEAQVMKKLRHEKLVQLYAVV 328 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V EYM GS+ ++ K +L ++A IA G+ Y+ + M +H Sbjct: 329 SEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHR 384 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + KVADFGLA+L Sbjct: 385 DLRAANILVGENLVCKVADFGLARL 409
>CDC2_PONPY (Q5RCH1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 69.7 bits (169), Expect = 7e-12 Identities = 50/152 (32%), Positives = 76/152 (50%), Gaps = 6/152 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNG--EDFISEVSTIGRIHHVNIVCLV 378 +K+G+G YG VYKG V +K + S G I E+S + + H NIV L Sbjct: 8 EKIGEGTYGVVYKGRHKTTGQVVTMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 Query: 379 GFCSEEMRRALVYEYMPNGSMD--KYIFSAEKSFSWDK--LNEIALGIARGINYLHQGCD 546 ++ R L++E++ SMD KY+ S D + I +GI + H Sbjct: 68 DVLMQDSRLYLIFEFL---SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS--- 121 Query: 547 MQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ++LH D+KP N+L+D K+ADFGLA+ + Sbjct: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF 153
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 69.7 bits (169), Expect = 7e-12 Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLGQG +G V+ G G VA+K L+ + + E F+ E + ++ H +V L Sbjct: 271 KLGQGCFGEVWMGTW-NGTTRVAIKTLKPGT-MSPEAFLQEAQVMKKLRHEKLVQLYAVV 328 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V EYM GS+ ++ K +L ++A IA G+ Y+ + M +H Sbjct: 329 SEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHR 384 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + KVADFGLA+L Sbjct: 385 DLRAANILVGENLVCKVADFGLARL 409
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 69.7 bits (169), Expect = 7e-12 Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLGQG +G V+ G G VA+K L+ + + E F+ E + ++ H +V L Sbjct: 271 KLGQGCFGEVWMGTW-NGTTRVAIKTLKPGT-MSPEAFLQEAQVMKKLRHEKLVQLYAVV 328 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V EYM GS+ ++ K +L ++A IA G+ Y+ + M +H Sbjct: 329 SEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHR 384 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + KVADFGLA+L Sbjct: 385 DLRAANILVGENLVCKVADFGLARL 409
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 69.7 bits (169), Expect = 7e-12 Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLGQG +G V+ G G VA+K L+ + + E F+ E + ++ H +V L Sbjct: 271 KLGQGCFGEVWMGTW-NGTTRVAIKTLKPGT-MSPEAFLQEAQVMKKLRHEKLVRLYAVV 328 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAE-KSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V EYM GS+ ++ K +L ++A IA G+ Y+ + M +H Sbjct: 329 SEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHR 384 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + KVADFGLA+L Sbjct: 385 DLRAANILVGENLVCKVADFGLARL 409
>CDK7_RAT (P51952) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 protein kinase) (P39 Mo15) (Fragment) Length = 329 Score = 69.3 bits (168), Expect = 9e-12 Identities = 47/151 (31%), Positives = 77/151 (50%), Gaps = 5/151 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFIS-----EVSTIGRIHHVNIV 369 D LG+G + TVYK + VA+K ++ +D I+ E+ + + H NI+ Sbjct: 8 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 67 Query: 370 CLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDM 549 L+ + +LV+++M ++ I + + L +G+ YLHQ Sbjct: 68 GLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW-- 124 Query: 550 QILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ILH D+KP+N+LLD N + K+ADFGLAK + Sbjct: 125 -ILHRDLKPNNLLLDENGVLKLADFGLAKSF 154
>TIE2_BRARE (O73791) Tyrosine-protein kinase receptor Tie-2 precursor (EC| 2.7.10.1) Length = 1116 Score = 69.3 bits (168), Expect = 9e-12 Identities = 47/165 (28%), Positives = 83/165 (50%), Gaps = 19/165 (11%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHV--AVKMLEEN-SNCNGEDFISEVSTIGRIH-HVNI 366 F+D LG+G +G V K + + + AVK +++ S + DF E+ + R+ H NI Sbjct: 818 FQDVLGEGNFGQVLKARIRKDGLRMDAAVKRMKDYASQDDHRDFAGELEVLCRLGPHKNI 877 Query: 367 VCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAE---------------KSFSWDKLNEIA 501 + L+G C L E+ P+G++ ++ + + S +L + Sbjct: 878 IHLLGACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPAFAIAHRTASTLSSQQLLAFS 937 Query: 502 LGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAK 636 +ARG++YL Q Q +H D+ N+L+ NF+ K+ADFGL++ Sbjct: 938 ADVARGMSYLSQ---KQFIHRDLAARNVLVGENFVAKIADFGLSR 979
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 69.3 bits (168), Expect = 9e-12 Identities = 45/145 (31%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLG G +G V++ L G VHVAVK++ ++ + F +E+ + ++ H +I+ L Sbjct: 196 KLGAGYFGEVFEA-LWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVA 254 Query: 388 SEEMRRALVYEYMPNGSMDKYI-FSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 + ++ E MP G++ + + S EK+ +L + A +A G+ YL +H Sbjct: 255 TAGDPVYIITELMPKGNLLQLLRDSDEKALPILELVDFASQVAEGMCYLE---SQNYIHR 311 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D+ N+L+ N + KV DFGLA+L Sbjct: 312 DLAARNVLVTENNLCKVGDFGLARL 336
>CDK7_MOUSE (Q03147) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinas Length = 346 Score = 69.3 bits (168), Expect = 9e-12 Identities = 47/151 (31%), Positives = 77/151 (50%), Gaps = 5/151 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFIS-----EVSTIGRIHHVNIV 369 D LG+G + TVYK + VA+K ++ +D I+ E+ + + H NI+ Sbjct: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 Query: 370 CLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDM 549 L+ + +LV+++M ++ I + + L +G+ YLHQ Sbjct: 76 GLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW-- 132 Query: 550 QILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ILH D+KP+N+LLD N + K+ADFGLAK + Sbjct: 133 -ILHRDLKPNNLLLDENGVLKLADFGLAKSF 162
>CDK7_HUMAN (P50613) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) Length = 346 Score = 69.3 bits (168), Expect = 9e-12 Identities = 47/151 (31%), Positives = 77/151 (50%), Gaps = 5/151 (3%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFIS-----EVSTIGRIHHVNIV 369 D LG+G + TVYK + VA+K ++ +D I+ E+ + + H NI+ Sbjct: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 Query: 370 CLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDM 549 L+ + +LV+++M ++ I + + L +G+ YLHQ Sbjct: 76 GLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW-- 132 Query: 550 QILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 ILH D+KP+N+LLD N + K+ADFGLAK + Sbjct: 133 -ILHRDLKPNNLLLDENGVLKLADFGLAKSF 162
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 69.3 bits (168), Expect = 9e-12 Identities = 52/168 (30%), Positives = 82/168 (48%), Gaps = 17/168 (10%) Frame = +1 Query: 190 TRHFR----DKLGQGGYGTVYKGVLLPGDVHVAVKMLE-ENSNCNGEDFISEVSTIGRIH 354 T H R ++LG G Y TVYKG+ ++VA+K ++ ++ I E+S + + Sbjct: 4 TSHIRFKQLERLGNGTYATVYKGLNKTTGLYVALKEVKLDSEEGTPSTAIREISLMKELK 63 Query: 355 HVNIVCLVGFCSEEMRRALVYEYMPNGS---MDKYI---------FSAEKSFSWDKLNEI 498 H NIV L E + LV+E+M N MD + S K F W L Sbjct: 64 HENIVRLYDVIHTENKLTLVFEFMDNDLKKFMDSRLDREMPRGLELSLVKYFQWQLL--- 120 Query: 499 ALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLAKLY 642 +G+ + H+ +ILH D+KP N+L+++ K+ DFGLA+ + Sbjct: 121 -----QGVAFCHEN---RILHRDLKPQNLLINNKGQLKLGDFGLARAF 160
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 69.3 bits (168), Expect = 9e-12 Identities = 44/146 (30%), Positives = 77/146 (52%), Gaps = 3/146 (2%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGED---FISEVSTIGRIHHVNIVCLVG 381 LG+G +G K + V +++E C+ E F++EV + + H N++ +G Sbjct: 337 LGKGFFGQAIK---VTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIG 393 Query: 382 FCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILH 561 ++ + L+ EY+ G++ ++ +A+ F W + A GIA G+ YLH C I+H Sbjct: 394 VLYKDKKLNLLTEYIEGGTLKDFLRNADP-FPWQQKVSFAKGIASGMAYLHSMC---IIH 449 Query: 562 FDIKPHNILLDSNFIPKVADFGLAKL 639 D+ HN L+ + VADFGL++L Sbjct: 450 RDLNSHNCLIKLDKTVVVADFGLSRL 475
>ROR2_DROME (Q9V6K3) Tyrosine-protein kinase transmembrane receptor Ror2| precursor (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase) Length = 724 Score = 68.9 bits (167), Expect = 1e-11 Identities = 50/163 (30%), Positives = 89/163 (54%), Gaps = 19/163 (11%) Frame = +1 Query: 211 LGQGGYGTVYKGV---LLPG--DVHVAVKMLEENSNCNGE-DFISEVSTIGRIHHVNIVC 372 LGQG +G V++ L+P D+ VAVKML+++++ + DF E + H NIV Sbjct: 447 LGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVR 506 Query: 373 LVGFCSEEMRRALVYEYMPNGSMDKYI-----FSAEKSFSWDKLN-------EIALGIAR 516 L+G C+ L++EYM G + +++ ++ ++ + D+L ++A IA Sbjct: 507 LLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAA 566 Query: 517 GINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLA-KLY 642 G+ YL + + +H D+ N L++ + K+ADFGL+ K+Y Sbjct: 567 GMLYL---SERKFVHRDLATRNCLINEHMAVKIADFGLSHKIY 606
>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.11.1)| (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2) Length = 487 Score = 68.9 bits (167), Expect = 1e-11 Identities = 46/143 (32%), Positives = 75/143 (52%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGF 384 +KLG+G YG+VYK + VA+K + S+ ++ I E+S + + ++V G Sbjct: 34 EKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDL--QEIIKEISIMQQCDSPHVVKYYGS 91 Query: 385 CSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHF 564 + +V EY GS+ I K+ + D++ I +G+ YLH M+ +H Sbjct: 92 YFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF---MRKIHR 148 Query: 565 DIKPHNILLDSNFIPKVADFGLA 633 DIK NILL++ K+ADFG+A Sbjct: 149 DIKAGNILLNTEGHAKLADFGVA 171
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 68.9 bits (167), Expect = 1e-11 Identities = 49/154 (31%), Positives = 78/154 (50%), Gaps = 7/154 (4%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLP-----GDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVN 363 F +LG+G +G+V P G+V VAVK L+ ++ + DF E+ + + H N Sbjct: 851 FLQQLGKGNFGSVEMCRYDPLQDNTGEV-VAVKKLQHSTEEHLRDFEREIEILKSLQHDN 909 Query: 364 IVCLVGFCSEEMRR--ALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQ 537 IV G C RR L+ EY+P GS+ Y+ ++ KL + I +G+ YL Sbjct: 910 IVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLG- 968 Query: 538 GCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 + +H D+ NIL+++ K+ DFGL K+ Sbjct: 969 --TKRYIHRDLATRNILVENENRVKIGDFGLTKV 1000 Score = 49.7 bits (117), Expect = 7e-06 Identities = 38/141 (26%), Positives = 68/141 (48%), Gaps = 10/141 (7%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLP----GDVH---VAVKMLEENSNCNGEDFISEVSTIGRIHH 357 F + LGQG + ++KGV G +H V +K+L++ E F S + ++ H Sbjct: 547 FNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSH 606 Query: 358 VNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFS--WDKLNEIALGIARGINY- 528 ++V G C LV E++ GS+D Y+ + S + W LG+A+ + + Sbjct: 607 KHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILW------KLGVAKQLAWA 660 Query: 529 LHQGCDMQILHFDIKPHNILL 591 +H + ++H ++ NILL Sbjct: 661 MHFLEEKSLIHGNVCAKNILL 681
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 68.9 bits (167), Expect = 1e-11 Identities = 49/154 (31%), Positives = 78/154 (50%), Gaps = 7/154 (4%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLP-----GDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVN 363 F +LG+G +G+V P G+V VAVK L+ ++ + DF E+ + + H N Sbjct: 851 FLQQLGKGNFGSVEMCRYDPLQDNTGEV-VAVKKLQHSTEEHLRDFEREIEILKSLQHDN 909 Query: 364 IVCLVGFCSEEMRR--ALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQ 537 IV G C RR L+ EY+P GS+ Y+ ++ KL + I +G+ YL Sbjct: 910 IVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLG- 968 Query: 538 GCDMQILHFDIKPHNILLDSNFIPKVADFGLAKL 639 + +H D+ NIL+++ K+ DFGL K+ Sbjct: 969 --TKRYIHRDLATRNILVENENRVKIGDFGLTKV 1000 Score = 50.1 bits (118), Expect = 6e-06 Identities = 42/166 (25%), Positives = 76/166 (45%), Gaps = 18/166 (10%) Frame = +1 Query: 148 IGPTRYAYTDIIAITRH--------FRDKLGQGGYGTVYKGVLLP----GDVH---VAVK 282 I PT + ++ + H F + LGQG + ++KGV G +H V +K Sbjct: 522 ISPTLQRHNNVNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLK 581 Query: 283 MLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSA 462 +L++ E F S + ++ H ++V G C LV E++ GS+D Y+ Sbjct: 582 VLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKN 641 Query: 463 EKSFS--WDKLNEIALGIARGINY-LHQGCDMQILHFDIKPHNILL 591 + S + W LG+A+ + + +H + ++H ++ NILL Sbjct: 642 KNSINILW------KLGVAKQLAWAMHFLEEKSLIHGNVCAKNILL 681
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 68.9 bits (167), Expect = 1e-11 Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLGQG +G V+ G G VA+K L+ + E F+ E + ++ H +V L Sbjct: 272 KLGQGCFGEVWMGTW-NGTTKVAIKTLKLGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVV 329 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSF-SWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V E+M GS+ ++ E F +L ++A IA G+ Y+ + M +H Sbjct: 330 SEEPIY-IVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIER---MNYIHR 385 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + K+ADFGLA+L Sbjct: 386 DLRAANILVGDNLVCKIADFGLARL 410
>AL2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22)| (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) Length = 384 Score = 68.9 bits (167), Expect = 1e-11 Identities = 47/146 (32%), Positives = 72/146 (49%), Gaps = 2/146 (1%) Frame = +1 Query: 205 DKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDF--ISEVSTIGRIHHVNIVCLV 378 +KLG+G Y TVYKG+ VA+K++ N+ G F I E S + + H NIV L Sbjct: 56 EKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANIVLLH 114 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 + V+EYM + + +Y+ + + RG+ Y+H +L Sbjct: 115 DIIHTKETLTFVFEYM-HTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHH---QHVL 170 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+KP N+L+ K+ADFGLA+ Sbjct: 171 HRDLKPQNLLISHLGELKLADFGLAR 196
>SLK_MOUSE (O54988) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4) Length = 1233 Score = 68.6 bits (166), Expect = 2e-11 Identities = 41/142 (28%), Positives = 71/142 (50%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 +LG G +G VYK +V A K+++ S ED++ E+ + H NIV L+ Sbjct: 39 ELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAF 98 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFD 567 E ++ E+ G++D + E+ + ++ + +NYLH D +I+H D Sbjct: 99 YYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLEALNYLH---DNKIIHRD 155 Query: 568 IKPHNILLDSNFIPKVADFGLA 633 +K NIL + K+ADFG++ Sbjct: 156 LKAGNILFTLDGDIKLADFGVS 177
>DDR1_PANTR (Q7YR43) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (CD167a antigen) Length = 909 Score = 68.6 bits (166), Expect = 2e-11 Identities = 48/181 (26%), Positives = 87/181 (48%), Gaps = 35/181 (19%) Frame = +1 Query: 199 FRDKLGQGGYGTVYK----------GVLLPGDVH------VAVKMLEENSNCNGE-DFIS 327 F++KLG+G +G V+ + P +V VAVK+L ++ N DF+ Sbjct: 608 FKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLK 667 Query: 328 EVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAE-------------- 465 EV + R+ NI+ L+G C ++ ++ +YM NG +++++ + + Sbjct: 668 EVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQ 727 Query: 466 ----KSFSWDKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLA 633 + S+ L +A IA G+ YL + +H D+ N L+ NF K+ADFG++ Sbjct: 728 AAQGPTISYPMLLHVAAQIASGMRYL---ATLNFVHRDLATRNCLVGENFTIKIADFGMS 784 Query: 634 K 636 + Sbjct: 785 R 785
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 68.6 bits (166), Expect = 2e-11 Identities = 42/146 (28%), Positives = 71/146 (48%) Frame = +1 Query: 199 FRDKLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLV 378 F ++G G +G V+ G + VA+K + E S + EDFI E + ++ H +V L Sbjct: 273 FIKEIGSGQFGVVHLGEWR-SHIQVAIKAINEGS-MSEEDFIEEAKVMMKLSHSKLVQLY 330 Query: 379 GFCSEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQIL 558 G C + +V E+M NG + Y+ + + L + I G+ YL + + Sbjct: 331 GVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERN---GYI 387 Query: 559 HFDIKPHNILLDSNFIPKVADFGLAK 636 H D+ N L+ S I K++DFG+ + Sbjct: 388 HRDLAARNCLVSSTCIVKISDFGMTR 413
>SLK_CAVPO (O55092) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1231 Score = 68.6 bits (166), Expect = 2e-11 Identities = 41/142 (28%), Positives = 71/142 (50%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 +LG G +G VYK +V A K+++ S ED++ E+ + H NIV L+ Sbjct: 39 ELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAF 98 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFD 567 E ++ E+ G++D + E+ + ++ + +NYLH D +I+H D Sbjct: 99 YYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLEALNYLH---DNKIIHRD 155 Query: 568 IKPHNILLDSNFIPKVADFGLA 633 +K NIL + K+ADFG++ Sbjct: 156 LKAGNILFTLDGDIKLADFGVS 177
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 68.6 bits (166), Expect = 2e-11 Identities = 49/145 (33%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +1 Query: 208 KLGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFC 387 KLG G +G V+ G G VAVK L+ + + E F+ E + R+ H +V L Sbjct: 274 KLGNGQFGEVWMGTW-NGTTKVAVKTLKPGT-MSPEAFLEEAQIMKRLRHDKLVQLYAVV 331 Query: 388 SEEMRRALVYEYMPNGSMDKYIFSAEKSF-SWDKLNEIALGIARGINYLHQGCDMQILHF 564 SEE +V E+M GS+ ++ + + +L ++A IA G+ Y+ + M +H Sbjct: 332 SEEPIY-IVTEFMSQGSLLDFLKDGDGRYLKLPQLVDMAAQIAAGMAYIER---MNYIHR 387 Query: 565 DIKPHNILLDSNFIPKVADFGLAKL 639 D++ NIL+ N + K+ADFGLA+L Sbjct: 388 DLRAANILVGDNLVCKIADFGLARL 412
>DDR1_HUMAN (Q08345) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) Length = 913 Score = 68.6 bits (166), Expect = 2e-11 Identities = 48/181 (26%), Positives = 87/181 (48%), Gaps = 35/181 (19%) Frame = +1 Query: 199 FRDKLGQGGYGTVYK----------GVLLPGDVH------VAVKMLEENSNCNGE-DFIS 327 F++KLG+G +G V+ + P +V VAVK+L ++ N DF+ Sbjct: 612 FKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLK 671 Query: 328 EVSTIGRIHHVNIVCLVGFCSEEMRRALVYEYMPNGSMDKYIFSAE-------------- 465 EV + R+ NI+ L+G C ++ ++ +YM NG +++++ + + Sbjct: 672 EVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQ 731 Query: 466 ----KSFSWDKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPKVADFGLA 633 + S+ L +A IA G+ YL + +H D+ N L+ NF K+ADFG++ Sbjct: 732 AAQGPTISYPMLLHVAAQIASGMRYL---ATLNFVHRDLATRNCLVGENFTIKIADFGMS 788 Query: 634 K 636 + Sbjct: 789 R 789
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 68.6 bits (166), Expect = 2e-11 Identities = 43/143 (30%), Positives = 67/143 (46%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFCS 390 LG+G +G K + +K L F+ EV + + H N++ +G Sbjct: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404 Query: 391 EEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFDI 570 ++ R + EY+ G++ I S + + W + A IA G+ YLH M I+H D+ Sbjct: 405 KDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLH---SMNIIHRDL 461 Query: 571 KPHNILLDSNFIPKVADFGLAKL 639 HN L+ N VADFGLA+L Sbjct: 462 NSHNCLVRENRNVVVADFGLARL 484
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 68.6 bits (166), Expect = 2e-11 Identities = 43/143 (30%), Positives = 67/143 (46%) Frame = +1 Query: 211 LGQGGYGTVYKGVLLPGDVHVAVKMLEENSNCNGEDFISEVSTIGRIHHVNIVCLVGFCS 390 LG+G +G K + +K L F+ EV + + H N++ +G Sbjct: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404 Query: 391 EEMRRALVYEYMPNGSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFDI 570 ++ R + EY+ G++ I S + + W + A IA G+ YLH M I+H D+ Sbjct: 405 KDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLH---SMNIIHRDL 461 Query: 571 KPHNILLDSNFIPKVADFGLAKL 639 HN L+ N VADFGLA+L Sbjct: 462 NSHNCLVRENKNVVVADFGLARL 484
>EPHA6_RAT (P54758) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 68.6 bits (166), Expect = 2e-11 Identities = 56/189 (29%), Positives = 87/189 (46%), Gaps = 46/189 (24%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEE-NSNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L PG ++ VA+K L+ + + DF+ E S +G+ H NI+ L Sbjct: 636 IGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLE 695 Query: 379 G--------------FCSEEMRRA----------------------------LVYEYMPN 432 G FC +R +V EYM N Sbjct: 696 GVVTKRSFPAIGVEAFCPSFLRAGFLNGIQAPHPVTAGGSLPPRIPAGRPVMIVVEYMEN 755 Query: 433 GSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPK 612 GS+D ++ + F+ +L + GIA G+ YL DM +H D+ NIL++SN + K Sbjct: 756 GSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLS---DMGYVHRDLAARNILVNSNLVCK 812 Query: 613 VADFGLAKL 639 V+DFGL+++ Sbjct: 813 VSDFGLSRV 821
>EPHA6_MOUSE (Q62413) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 68.6 bits (166), Expect = 2e-11 Identities = 56/189 (29%), Positives = 87/189 (46%), Gaps = 46/189 (24%) Frame = +1 Query: 211 LGQGGYGTVYKGVL-LPG--DVHVAVKMLEE-NSNCNGEDFISEVSTIGRIHHVNIVCLV 378 +G G +G V G L PG ++ VA+K L+ + + DF+ E S +G+ H NI+ L Sbjct: 636 IGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLE 695 Query: 379 G--------------FCSEEMRRA----------------------------LVYEYMPN 432 G FC +R +V EYM N Sbjct: 696 GVVTKRSFPAIGVEAFCPSFLRAGFLNGIQAPHPVTAGGSLPPRIPAGRPVMIVVEYMEN 755 Query: 433 GSMDKYIFSAEKSFSWDKLNEIALGIARGINYLHQGCDMQILHFDIKPHNILLDSNFIPK 612 GS+D ++ + F+ +L + GIA G+ YL DM +H D+ NIL++SN + K Sbjct: 756 GSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLS---DMGYVHRDLAARNILVNSNLVCK 812 Query: 613 VADFGLAKL 639 V+DFGL+++ Sbjct: 813 VSDFGLSRV 821 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 103,445,549 Number of Sequences: 219361 Number of extensions: 2393952 Number of successful extensions: 10128 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 8188 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 8854 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6029593548 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
