ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bah63i19 |
|---|---|
| Clone Library Name | barley_pub |
>LEU22_METJA (P81291) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 424 Score = 213 bits (543), Expect = 4e-55 Identities = 108/227 (47%), Positives = 149/227 (65%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 MT EKILA+AS + + PG+ V ++DV M HD+ GP T+ K E+G + KVW+ EK+ Sbjct: 3 MTIVEKILAKASGKKEVSPGDIVMANIDVAMVHDITGPLTVNTLK-EYGIE-KVWNPEKI 60 Query: 224 VIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQE 403 VI+ DH + +A N ++R F +EQ IKYFYDI++ GVCH L ++ Sbjct: 61 VILFDHQVPADSIKAAENHILMRKFVKEQGIKYFYDIRE-----------GVCHQVLPEK 109 Query: 404 GHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMP 583 GH PGEV++G DSHTC GAFG FATGIG+TD V TGK KVP TI F + G++ Sbjct: 110 GHVAPGEVVVGADSHTCTHGAFGAFATGIGSTDMAHVFATGKLWFKVPETIYFNITGDLQ 169 Query: 584 PYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 PY+ +KD+IL IIGE+ V GATY++ +F G T++ +++ RMT+ NM Sbjct: 170 PYVTSKDVILSIIGEVGVDGATYKACQFGGETVKKMSIASRMTMTNM 216
>LEU21_METTH (O27439) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 419 Score = 208 bits (530), Expect = 1e-53 Identities = 108/227 (47%), Positives = 147/227 (64%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 MT +EKILARAS + +E GE V D+DV MTHD+ GP ++ F+ GED +VWD EK+ Sbjct: 3 MTVSEKILARASGKDRVEAGEIVMADIDVAMTHDLTGPLSVESFRA-IGED-RVWDPEKI 60 Query: 224 VIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQE 403 V+I DH + A +N I+RDF +EQ I+ FYD+++ GVCH L ++ Sbjct: 61 VVIFDHQVPADSIEAAQNHMIMRDFVEEQGIRNFYDVRE-----------GVCHQVLPEK 109 Query: 404 GHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMP 583 GH PGEV++GTDSHTC GA G FATGIG+TD V TGK +VP T+RF + G++ Sbjct: 110 GHVVPGEVVVGTDSHTCTHGALGAFATGIGSTDMAMVFATGKLWFRVPETLRFDVRGKLR 169 Query: 584 PYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ AKD+IL IIG + GATY + EF G T+ +++ +RM L NM Sbjct: 170 EHVYAKDVILNIIGRVGADGATYMACEFAGETVAEMSVSDRMVLSNM 216
>LEU21_METKA (Q8TVF2) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 418 Score = 189 bits (481), Expect = 6e-48 Identities = 97/226 (42%), Positives = 141/226 (62%) Frame = +2 Query: 47 TTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVV 226 T EKIL+RAS + E G+ V ++DV M HD+ GP T+ +E G + +VWD K+V Sbjct: 4 TMAEKILSRASGEDA-EAGDIVVANIDVAMVHDITGPITVQRL-EEMGVE-RVWDPSKIV 60 Query: 227 IIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEG 406 ++ DH + A N I+R+F +EQ I++FYD+++ GVCH L ++G Sbjct: 61 VLFDHQVPADSVEAAENHKIMREFVEEQGIEHFYDVRE-----------GVCHQVLPEKG 109 Query: 407 HCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPP 586 H RPG+V++G DSHTC GA G FATGIG+TD V TGK +VP T R + GE+P Sbjct: 110 HVRPGDVIVGADSHTCTHGALGAFATGIGSTDMAAVFATGKLWFRVPETYRVEITGELPE 169 Query: 587 YLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + AKD++L++ GEI GATY ++E+ G + +++ +RM LCNM Sbjct: 170 GVYAKDVVLKVTGEIGADGATYMAIEYHGEVVREMSVSDRMCLCNM 215
>LEU22_METMA (Q8PUG1) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 420 Score = 184 bits (467), Expect = 2e-46 Identities = 100/231 (43%), Positives = 144/231 (62%), Gaps = 4/231 (1%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGP----GTIGIFKQEFGEDAKVWD 211 MT +EKI ++AS ++ G+ V ++D+ MTHD+ GP G I + E ED KVWD Sbjct: 1 MTVSEKIFSKASG-TPVKAGDFVLANIDLAMTHDITGPLAVQGFYEIMRDE--EDKKVWD 57 Query: 212 REKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIA 391 K+VII DH + A +N +LR F +EQ I YD+ Y+GVCH Sbjct: 58 PSKIVIIFDHQVPADSINAAQNHIMLRKFAKEQGILN-YDV-----------YEGVCHQV 105 Query: 392 LAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLD 571 L ++GH +PG++++G+DSHTC G+ G F+TGIG+TD V TGK +VP T RF ++ Sbjct: 106 LPEKGHVKPGDLIVGSDSHTCAYGSLGAFSTGIGSTDMAAVFATGKLWFRVPETFRFEVE 165 Query: 572 GEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G++P + +KDLIL +IG++ V G Y + E+ GSTI SL++ ERMT+ NM Sbjct: 166 GKLPERVYSKDLILHLIGDVGVEGVRYMAAEYAGSTIRSLSIPERMTMSNM 216
>LEU22_METAC (Q8TQZ3) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 420 Score = 182 bits (462), Expect = 9e-46 Identities = 100/231 (43%), Positives = 143/231 (61%), Gaps = 4/231 (1%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGP----GTIGIFKQEFGEDAKVWD 211 MT +EKI ++AS ++ G+ V ++D+ MTHD+ GP G I + E E+ KVWD Sbjct: 1 MTVSEKIFSKASG-TPVKAGDFVLANIDLAMTHDITGPLAVQGFYEIMRDE--EEKKVWD 57 Query: 212 REKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIA 391 K+VII DH + A N +LR F +EQ I YD+ Y+GVCH Sbjct: 58 PSKIVIIFDHQVPADSINAAENHIMLRKFAKEQGILN-YDV-----------YEGVCHQV 105 Query: 392 LAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLD 571 L ++GH PG++++G+DSHTC G+ G F+TGIG+TD V TGK +VP T RF ++ Sbjct: 106 LPEKGHVLPGDLIVGSDSHTCAYGSLGAFSTGIGSTDMAAVFATGKLWFRVPETFRFEVE 165 Query: 572 GEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G++P + +KDLIL +IG++ V GA Y + E+ GSTI SL++ ERMT+ NM Sbjct: 166 GKLPERVYSKDLILHLIGDVGVEGARYMAAEYAGSTIRSLSIPERMTISNM 216
>LEU22_METTH (O27668) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 428 Score = 182 bits (462), Expect = 9e-46 Identities = 101/229 (44%), Positives = 131/229 (57%), Gaps = 2/229 (0%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQ--EFGEDAKVWDRE 217 M TEKILA A+ + PGE + VD+ MTHD P TI F+ G A+VWD E Sbjct: 4 MNMTEKILAEAAGLREVTPGEIIEARVDLAMTHDGTSPPTIRTFRDIASRGGPARVWDPE 63 Query: 218 KVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALA 397 ++V++ DH + A + R+F +EQ I + + G+CH L Sbjct: 64 RIVMVFDHNVPANTIGAAEFQRVTREFAREQGIVNIFQ-----------NAAGICHQVLP 112 Query: 398 QEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGE 577 + G RPG V++G DSHTC GAFG FATG+G TD V TGK VP +R + GE Sbjct: 113 ERGFVRPGMVIVGADSHTCTYGAFGAFATGMGATDMAMVFATGKTWFMVPEAMRIEVTGE 172 Query: 578 MPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ AKD+IL IIGEI V GATYRS+EF G TIES+ + RMT+CNM Sbjct: 173 PEGHVYAKDVILHIIGEIGVDGATYRSVEFTGDTIESMDVSGRMTICNM 221
>LEU2_AQUAE (O67078) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 432 Score = 178 bits (452), Expect = 1e-44 Identities = 89/227 (39%), Positives = 144/227 (63%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 MT TEKILA + + + PGE + +D+ M +DV P I I +++G D KV+D E++ Sbjct: 3 MTITEKILAEHAGKKEVHPGELITAKIDLAMANDVTAPLAIKIL-EKYGID-KVFDPERI 60 Query: 224 VIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQE 403 ++ H++ D ++ I+R+F ++ IK+F++ + +G+ H L ++ Sbjct: 61 ALVLSHFVPAKDIKSAEQAKIVREFVKKHGIKWFFE-----------EGEGIEHAILPEQ 109 Query: 404 GHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMP 583 G PG++++G DSHTC GA G FATG+G+TD + M TG+ L+VP +++F+ G++ Sbjct: 110 GLVVPGDLVVGADSHTCTYGALGAFATGVGSTDIAYAMATGEVWLRVPESMKFIFYGKLK 169 Query: 584 PYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P+++ KDLIL IG+I V GA YR+MEF G TI +L+ME+R T+ NM Sbjct: 170 PWVMGKDLILYTIGQIGVDGALYRAMEFDGETIRNLSMEQRFTIANM 216
>LEU21_PYRAB (Q9UZ07) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 423 Score = 178 bits (451), Expect = 2e-44 Identities = 97/227 (42%), Positives = 139/227 (61%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 MT EKILA SER ++PGE V +D + +DV P I F+ E G +V+DRE++ Sbjct: 3 MTIAEKILADHSEREEVKPGEIVMAKLDFVFGNDVTMPLAIKKFR-ELGVK-RVFDRERI 60 Query: 224 VIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQE 403 I+ DH+ D ++ R+F +E IK+F++ + GV H L + Sbjct: 61 AIVLDHFTPNKDIKSAEQCKSSREFAKEMGIKWFFEGGSV----------GVEHCLLPEL 110 Query: 404 GHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMP 583 G PG++++G DSHTC GA G FATG+G+TD M TG+A +VP T++F+ +GE+ Sbjct: 111 GLVLPGDLIIGADSHTCTYGALGAFATGVGSTDLAVAMATGEAWFRVPETMKFIYEGELQ 170 Query: 584 PYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 PY+ KDLIL IG+I V+GA Y+ MEF GS IE L++E+RMT+ NM Sbjct: 171 PYVTGKDLILHTIGDIGVNGALYKVMEFSGSVIEELSVEQRMTMSNM 217
>LEU21_PYRFU (Q8U2A1) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 424 Score = 176 bits (447), Expect = 5e-44 Identities = 96/227 (42%), Positives = 139/227 (61%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 MT EKILA + + ++PGE V VD + +DV P I F++ E KV+D E++ Sbjct: 4 MTIAEKILATHAGKEEVKPGEIVLAKVDFMFGNDVTTPLAIKTFRKIGVE--KVFDPERI 61 Query: 224 VIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQE 403 I+ DH+ D +A R+F +EQ IK+F++ ++ GV H L + Sbjct: 62 AIVLDHFTPNKDIKAAEQCKFSREFAREQGIKWFFEGGNV----------GVEHCLLPEL 111 Query: 404 GHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMP 583 G PGE+++G DSHTC GA G FATG+G+TD M TG+A +VP TI+FV +G++ Sbjct: 112 GLVLPGELIIGADSHTCTYGALGAFATGVGSTDLAVAMATGEAWFRVPETIKFVYEGDLQ 171 Query: 584 PYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P++ +KDLIL IG+I V+GA Y+ MEF G IE L++E+RMT+ NM Sbjct: 172 PWVTSKDLILYTIGDIGVNGALYKVMEFSGEVIEKLSVEQRMTMTNM 218
>LEU21_ARCFU (O28316) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 418 Score = 172 bits (436), Expect = 9e-43 Identities = 90/226 (39%), Positives = 133/226 (58%) Frame = +2 Query: 47 TTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVV 226 T EKI ++AS + ++ GE V ++D+ M HD+ P I F++ G DAKVWD+ KV+ Sbjct: 4 TLVEKIFSKASGK-EVKAGEFVMANIDLAMIHDITAPLAIKAFREILGSDAKVWDKSKVI 62 Query: 227 IIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEG 406 + DH + A N +LR F +EQ I YD+K G+ H + E Sbjct: 63 MAFDHQVPADSVHAAENHKMLRKFAEEQGILN-YDVKG-----------GIAHQIMV-EN 109 Query: 407 HCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPP 586 H PG +++G DSHTC GA G FATGIG+TD GFV+ GK KVP +IRF + G++ Sbjct: 110 HVEPGMLIVGADSHTCMYGALGAFATGIGSTDMGFVLAMGKLWFKVPESIRFNVHGKLEK 169 Query: 587 YLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ KD++L++IG + GA Y++ + G +E L M +R+T+CNM Sbjct: 170 HVYGKDIVLKLIGMVGADGANYKACIYSGEVVEKLGMSDRLTMCNM 215
>LEU2_CLOAB (Q97EE0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 422 Score = 172 bits (436), Expect = 9e-43 Identities = 89/231 (38%), Positives = 144/231 (62%) Frame = +2 Query: 32 VKSPMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWD 211 +K PMT T+KILA + +E G+ + ++D+++ +DV P + FK G + KV+D Sbjct: 1 MKKPMTMTQKILANHAGLDYVEAGQLITANLDLVLGNDVTTPVAVKAFKT-MGTN-KVFD 58 Query: 212 REKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIA 391 ++KV I+PDH+ D ++ + ++R F + ++I+ +++I ++ G+ H Sbjct: 59 KKKVAIVPDHFTPNKDIKSAEHCKMIRQFAKSKEIENYFEIGEM----------GIEHAL 108 Query: 392 LAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLD 571 + ++G PG+V++G DSHTC GA G F+TG+G+TD M TGKA KVP I+FVL Sbjct: 109 IPEKGLAVPGDVIIGADSHTCTYGALGVFSTGVGSTDMAVGMATGKAWFKVPEAIKFVLK 168 Query: 572 GEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G+ ++ KD+IL IIG I V GA Y+SME+ G +E L+M++R T+ NM Sbjct: 169 GKPAKWVSGKDIILHIIGMIGVDGALYKSMEYTGDGLEYLSMDDRFTIANM 219
>LEU2_THETN (Q8RDK2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 418 Score = 168 bits (426), Expect = 1e-41 Identities = 89/227 (39%), Positives = 145/227 (63%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 +T T+KIL+ + R ++PGE + +DVD+++ +D+ P I F ++ G D KV+D K+ Sbjct: 3 LTLTQKILSAKAGR-EVKPGELIEIDVDMVLGNDITAPVAIKEF-EKIGVD-KVFDNTKI 59 Query: 224 VIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQE 403 ++PDH++ + D ++ V+++R F ++ I F+++ + G+ H L ++ Sbjct: 60 ALVPDHFVPSKDIKSAEQVNVMRKFAKKYNIVNFFEVGRM----------GIEHALLPEQ 109 Query: 404 GHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMP 583 G PG+V++G DSHTC GA FATG+G+TD M TGKA KVP I+FVL G + Sbjct: 110 GLVLPGDVVIGADSHTCTYGALTCFATGVGSTDMAAAMATGKAWFKVPEAIKFVLKGNLG 169 Query: 584 PYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ KD+IL IIG+I V GA Y+SMEF G+ I++L++++R T+ NM Sbjct: 170 KWVSGKDVILYIIGKIGVDGALYKSMEFTGN-IKALSIDDRFTIANM 215
>LEU2_WOLSU (Q7M9Z9) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 422 Score = 161 bits (407), Expect = 2e-39 Identities = 86/226 (38%), Positives = 136/226 (60%) Frame = +2 Query: 47 TTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVV 226 T TEKI + A + GE + +D+++ +D+ P +I F++ K+ + + Sbjct: 4 TLTEKIFS-AHTNKQVSAGEIIESPIDMVIGNDITTPLSIRAFEESGA--TKLANPDGFC 60 Query: 227 IIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEG 406 I+ DH+I D + I RDF ++ ++K+++D +D+ G+ H L ++G Sbjct: 61 IVMDHFIPAKDIASANQARISRDFAKKHQLKHYFDERDM----------GIEHAILPEKG 110 Query: 407 HCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPP 586 PG+V++G DSHTC GA G FATG+G+TD + M TGK KVPP+IR V G++ Sbjct: 111 LVLPGDVIIGADSHTCTHGALGAFATGMGSTDLAYAMITGKNWFKVPPSIRVVFKGKLQE 170 Query: 587 YLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ KDLIL+II +I V GA Y+++EF G TIE L+M++R +LCNM Sbjct: 171 HVYGKDLILEIIRQIGVDGALYKALEFQGDTIEQLSMDDRFSLCNM 216
>LEU2_HELHP (Q7VH31) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 420 Score = 159 bits (402), Expect = 8e-39 Identities = 83/227 (36%), Positives = 137/227 (60%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 MT ++KILA + S+ P + + +D+++ +D+ P I FK+ + KV+D++K+ Sbjct: 3 MTMSQKILADRAGLESVRPNDLIMAKLDMVLGNDITTPVAINAFKE--AKFQKVFDKDKI 60 Query: 224 VIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQE 403 ++ DH+ D +A R F ++ I ++YD+ ++ GV H L ++ Sbjct: 61 SLVMDHFAPNKDIKAATQSAQCRCFAKDFDISHYYDVGNM----------GVEHALLPEQ 110 Query: 404 GHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMP 583 G G++++G DSHTC GA G F+TG+G+TD M TG+A KVP I+F L G++ Sbjct: 111 GIVTIGDLIIGADSHTCTYGALGAFSTGVGSTDMAVGMATGQAWFKVPYAIKFNLKGKLR 170 Query: 584 PYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 PY+ KD+IL IIG+I V GA Y+SMEF G +++LT+++R+ + NM Sbjct: 171 PYVSGKDVILHIIGKIGVDGALYKSMEFGGEGLKNLTIDDRLCIANM 217
>LEU22_THEMA (Q9WZ24) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 417 Score = 155 bits (391), Expect = 2e-37 Identities = 85/228 (37%), Positives = 140/228 (61%), Gaps = 1/228 (0%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 MT EKIL++ + R +EPGE + ++ D+ + +D+ P I FK+ G+ K DR V Sbjct: 1 MTLAEKILSQKAGR-KVEPGEFLLLEPDIALANDITAPLAIKKFKEYGGKKVKYPDR--V 57 Query: 224 VIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQE 403 V++PDH+ D ++ V ++R+F +EQ I+ F++I + G+ H+ L +E Sbjct: 58 VLVPDHFTPNKDIKSAMQVKMMREFAREQGIEKFFEIGRM----------GIEHVLLPEE 107 Query: 404 GHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTD-AGFVMGTGKALLKVPPTIRFVLDGEM 580 G + G++++G DSHTC GA G FATG+G+TD AGF + GK +VP +I+ L G+ Sbjct: 108 GIVKSGDLVVGADSHTCTYGALGAFATGVGSTDIAGFYL-IGKVWFRVPESIKVTLRGKF 166 Query: 581 PPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + AKDL+L++I + V GA Y+++EF G ++ ++M+ R T+ NM Sbjct: 167 KDLVTAKDLVLKLISILGVDGANYKAIEFSGPGVKEISMDGRFTISNM 214
>LEU21_METAC (Q8TLF1) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 424 Score = 154 bits (390), Expect = 2e-37 Identities = 85/226 (37%), Positives = 127/226 (56%) Frame = +2 Query: 47 TTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVV 226 T +EKI +RA+ + + + V DVD M HD + FK+ E KVWD ++V Sbjct: 14 TISEKIFSRAAGTEA-KANDFVLADVDYAMAHDGTSVLAVNAFKEM--EMEKVWDPSRIV 70 Query: 227 IIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEG 406 + DH +E + +R++ +EQ I FY++ + G+CH L + G Sbjct: 71 VPFDHIAPANNETSATLQREIREWVKEQGIPNFYEVGE-----------GICHQVLPENG 119 Query: 407 HCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPP 586 PG++++G DSH+C GAFG FATG+G TD + TGK KVP + R ++G + Sbjct: 120 FALPGKLVVGADSHSCTYGAFGAFATGVGATDMAEIFATGKLWFKVPESFRMTVEGSLRK 179 Query: 587 YLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + AKDL L +IG+ ++GATY+++EF G I LT+ RMTLCNM Sbjct: 180 GVYAKDLTLYLIGKTGIAGATYKAVEFYGQAIRELTVAGRMTLCNM 225
>LEU22_DEIRA (Q9RTI6) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 431 Score = 152 bits (383), Expect = 1e-36 Identities = 83/227 (36%), Positives = 129/227 (56%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 MT EK+LA S ++ PG+ + D ++ H++ P + + +E G D +V+D +K+ Sbjct: 3 MTIAEKMLAAHSGHDTVVPGQLIECATDWVLCHEITTPAALRML-EERGMD-RVFDPQKI 60 Query: 224 VIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQE 403 V +PDH + + +A + L+ + QE+ I++FYD+ G+ H+ L Sbjct: 61 VAVPDHSVPAMNIKAAKMYQKLKSWVQEKGIEHFYDV----------GRGGIAHVVLENT 110 Query: 404 GHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMP 583 G +PG+ L+ DSHTCNAGA G FATG+G+TD + GK KVP T+ + G+ Sbjct: 111 GLMKPGQTLVSGDSHTCNAGALGAFATGVGSTDLAGAIYAGKVWFKVPETMLIRVTGKTN 170 Query: 584 PYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P + KD++L++I +I GA Y ME+VG I+ L ME R TL NM Sbjct: 171 PGVTPKDIVLEVIKQIGADGANYMVMEWVGDYIDQLDMEGRFTLTNM 217
>LEU21_METMA (Q8PZT3) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 391 Score = 150 bits (378), Expect = 5e-36 Identities = 79/202 (39%), Positives = 114/202 (56%) Frame = +2 Query: 119 DVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDF 298 DVD M HD + FK+ E +VWD ++VI DH E + +R++ Sbjct: 4 DVDYAMAHDGTSILAVNAFKEM--EMERVWDPSRIVIPFDHIAPANTETSATLQKEIREW 61 Query: 299 CQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQF 478 +EQ I FY+I + G+CH L + G PG++L+G DSH+C GAFG F Sbjct: 62 VREQSIPNFYEIGE-----------GICHQVLPENGFALPGKLLVGADSHSCTYGAFGAF 110 Query: 479 ATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRS 658 ATG+G TD + TGK KVP + R ++G + ++ AKDL L +IG+ ++GATY++ Sbjct: 111 ATGVGATDMAEIFATGKLWFKVPESFRMTVEGSLDKHVYAKDLTLYLIGKTGIAGATYKA 170 Query: 659 MEFVGSTIESLTMEERMTLCNM 724 +EF G I L++ RMTLCNM Sbjct: 171 VEFYGQAISELSVAGRMTLCNM 192
>LEU21_THEMA (Q9WYC7) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 418 Score = 132 bits (332), Expect = 1e-30 Identities = 79/226 (34%), Positives = 127/226 (56%) Frame = +2 Query: 47 TTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVV 226 T EKI + R ++ GE V VD+ M D GP I F++ ++ KV K Sbjct: 4 TLAEKIFSEHVGR-DVKAGEIVLARVDIAMAQDGTGPLMINEFRELGFKEVKV---PKAF 59 Query: 227 IIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEG 406 + DH + + + + ++R+F +E +K F D D G+ H LA++ Sbjct: 60 LFIDHASPSPRKELSNSQKMMREFGKEMGVKVF----DAGD--------GISHQILAEK- 106 Query: 407 HCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPP 586 + +PG+++ G DSHTC AG G F TG+G+TD + G G+ KVP TI+ V++G++ Sbjct: 107 YVKPGDLVAGADSHTCTAGGLGAFGTGMGSTDVAIIFGLGQNWFKVPETIKVVVNGKLQD 166 Query: 587 YLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + AKD+IL+I + GATY+++EF GS IE++ +E+R+T+ NM Sbjct: 167 GVYAKDIILEIARILGSDGATYKALEFHGSCIENMNVEDRLTISNM 212
>LEU22_ARCFU (O28084) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 416 Score = 128 bits (322), Expect = 2e-29 Identities = 78/226 (34%), Positives = 122/226 (53%) Frame = +2 Query: 47 TTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVV 226 T EKIL+ S ++ G+ V ++D + D P I E G + + DR Sbjct: 4 TIAEKILSEKS-KSDAYAGDIVVAEIDQIALQDGTAPLAIRQL-MELGTEVRAADRT--- 58 Query: 227 IIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEG 406 H+ + R R+ +QK Y + K +DF NP +G+ H + E Sbjct: 59 ----HFFVDHAAPSPR-----RELSNDQKFIYEFAKKVGADF--NPPGEGIIHQIMV-ER 106 Query: 407 HCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPP 586 + +PG++ +G DSHTC G G F+TG+G+TD + GK +VP + R LDG +P Sbjct: 107 YVKPGDLAVGADSHTCTYGGIGAFSTGMGSTDVAVAIALGKNWFRVPESFRVQLDGSLPK 166 Query: 587 YLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + AKD+IL++IG++ V GATY+++EF G E++T+EER+T+ NM Sbjct: 167 GVFAKDVILKLIGDLGVDGATYKALEFHGECAENMTVEERLTIANM 212
>LEU21_METJA (Q58409) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 420 Score = 127 bits (319), Expect = 3e-29 Identities = 81/229 (35%), Positives = 123/229 (53%), Gaps = 2/229 (0%) Frame = +2 Query: 44 MTTTEKILARASERASLE--PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDRE 217 MT EKIL S++ E G+++ V+VD+ MTHD P K+ VW+ + Sbjct: 1 MTLVEKIL---SKKVGYEVCAGDSIEVEVDLAMTHDGTTPLAYKALKEM---SDSVWNPD 54 Query: 218 KVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALA 397 K+V+ DH + +A + +F + IK F+ +G+CH LA Sbjct: 55 KIVVAFDHNVPPNTVKAAEMQKLALEFVKRFGIKNFHK-----------GGEGICHQILA 103 Query: 398 QEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGE 577 E + P + G DSHTC GAFG FATG G TD ++ TG+ +KVP TIR + G+ Sbjct: 104 -ENYVLPNMFVAGGDSHTCTHGAFGAFATGFGATDMAYIYATGETWIKVPKTIRVDIVGK 162 Query: 578 MPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + AKD++L++ EI GATY ++E+ G ++++ M+ R+TLCNM Sbjct: 163 -NENVSAKDIVLRVCKEIGRRGATYMAIEYGGEVVKNMDMDGRLTLCNM 210
>LEU2_PICTO (Q6L0K5) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 413 Score = 127 bits (318), Expect = 5e-29 Identities = 76/226 (33%), Positives = 117/226 (51%) Frame = +2 Query: 47 TTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVV 226 T EKI + S + G+ V ++D +M +D+ GP I F E G +++V Sbjct: 3 TAVEKIFSDKSGNDA-RAGDYVIANLDYVMVNDITGPIAIDAFN-ELGYKPL---SDRIV 57 Query: 227 IIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEG 406 +IPDH++ D + ++DF + +FYD+ GVCH + ++G Sbjct: 58 VIPDHFVPPKDINSAIQYKKVKDFALKHNT-HFYDL----------GRGGVCHQVMMEKG 106 Query: 407 HCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPP 586 PG ++ G DSHT GA + GIG+T+AG + GTG+ KVP T ++G Sbjct: 107 FAAPGRLIAGADSHTNTYGALSCVSVGIGSTEAGVIFGTGRMWFKVPETDLIRINGRPKK 166 Query: 587 YLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + KD+IL ++ I G+ Y+ MEF GSTI+ L + ERMT+ NM Sbjct: 167 GVYGKDIILNVLSRIGNGGSAYKCMEFTGSTIDYLDINERMTMANM 212
>LEU22_METKA (Q8TW29) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 402 Score = 120 bits (302), Expect = 3e-27 Identities = 75/212 (35%), Positives = 117/212 (55%), Gaps = 1/212 (0%) Frame = +2 Query: 92 LEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD-ERA 268 +E GE V+V+ DV+M HD G + + E G + +V EKVV+I DH + + E A Sbjct: 17 VEAGETVYVEPDVIMLHDGSGATALRTLR-ELGVE-RVESPEKVVLIFDHSVPPSSVEAA 74 Query: 269 NRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSH 448 NR ++L +F + +I++ + + GVCH L +EG+ PG V+ G DSH Sbjct: 75 NRQNELL-EFARRHRIEHVHVDE------------GVCHQVLVEEGYAGPGRVVFGGDSH 121 Query: 449 TCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGE 628 T +GA A G G TD F + G+ ++VP T+R ++GE+ AKDL L ++GE Sbjct: 122 TPTSGAASALAFGFGGTDMAFALLYGELWIRVPRTVRVHVEGELEEPATAKDLALTVVGE 181 Query: 629 ISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + A Y +E+ G E +++ +RM LCN+ Sbjct: 182 LGAGYADYAVLEYTGLP-ERMSLGDRMCLCNL 212
>LEU2_RHOBA (Q7UIA7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 485 Score = 118 bits (295), Expect = 2e-26 Identities = 76/248 (30%), Positives = 127/248 (51%), Gaps = 9/248 (3%) Frame = +2 Query: 8 TRPASTGSVKSPMTTTEKILARASERASLEPGEN--VWVDVDVLMTHDVCGPGTIGIFKQ 181 T P+ G+ S T + +L + ++ + E+ + +D+ + H+V P F+ Sbjct: 7 TAPSQAGAT-SQSTGSRTLLDKIWDQHLVHAPESGPAIIYIDLHLVHEVTSPQA---FEG 62 Query: 182 EFGEDAKVWDREKVVIIPDHYIFTADER-------ANRNVDILRDFCQEQKIKYFYDIKD 340 + V E+ + PDH + T+D + + ++ LR+ C+E ++ F D Sbjct: 63 LRINNRPVRRPERTIATPDHNVPTSDRSLPIADPISRKQIETLRENCKEFGVQLF----D 118 Query: 341 LSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMG 520 + D R +G+ H+ + G+ +PG ++ DSHT GAFG A GIG ++ V+ Sbjct: 119 IDDVR-----QGIVHVIGPENGYTQPGMTIVCGDSHTATHGAFGSLAFGIGTSEVEHVLA 173 Query: 521 TGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTME 700 T L P T +DGE+ + AKD+IL +IG+I +G T +EF G + +LTME Sbjct: 174 TQTLLQFKPKTFELRVDGELARGVTAKDMILYLIGQIGTAGGTGYVLEFTGDAVRNLTME 233 Query: 701 ERMTLCNM 724 ERMT+CNM Sbjct: 234 ERMTVCNM 241
>LEU2_SULAC (Q4JC09) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 414 Score = 115 bits (288), Expect = 1e-25 Identities = 74/228 (32%), Positives = 119/228 (52%) Frame = +2 Query: 41 PMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREK 220 P T TEKIL+RAS + ++ PG+ + VD++ HD+ G I + ++ G KV+DREK Sbjct: 2 PQTLTEKILSRASGK-NVSPGDVTEIKVDLVAFHDLTGYHVIEVM-EDVGT-LKVFDREK 58 Query: 221 VVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQ 400 +VI DH D R+ +R+F ++ + FYDI G+ H + Sbjct: 59 LVIAFDHLAPPPDVRSAEIQGQIRNFVKKTSVPNFYDINS-----------GILHQIMI- 106 Query: 401 EGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEM 580 E + PG+V++ DSHT +GA G FA G+G +D + TGK + VP + L+G+ Sbjct: 107 ERYANPGQVIVAADSHTSTSGAVGAFAQGLGASDVAAAVITGKTWVMVPQPFKITLEGKP 166 Query: 581 PPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ KD+ L+I+G+ S+E ++ M+ R T+ NM Sbjct: 167 ARWINGKDIALKILGDFKADYFNGMSLEIFVKEPSAVPMDFRATVSNM 214
>LEU2_SULTO (Q974R0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 415 Score = 115 bits (288), Expect = 1e-25 Identities = 76/228 (33%), Positives = 119/228 (52%) Frame = +2 Query: 41 PMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREK 220 P T TEKIL+RAS + S+ PG+ V V VD+ HD+ G I + ++ KV+D++K Sbjct: 2 PQTLTEKILSRASGK-SVAPGDVVEVKVDIAAFHDLTGYHVIEVMEK--AGMLKVFDKQK 58 Query: 221 VVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQ 400 +VI DH D R+ +R F +E KI F+DI G+ H L + Sbjct: 59 IVIAFDHLAPPPDVRSAEIQTQIRKFVKELKIPNFHDIN-----------VGILHQILLE 107 Query: 401 EGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEM 580 + + PG V++ DSHT +GA G FA G+G +D + TGK + VP + + +L+G+ Sbjct: 108 K-YANPGYVIVAADSHTTTSGAVGAFAQGLGASDVAAAVITGKTWVMVPQSFKIMLEGKP 166 Query: 581 PPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ KD+ L+I+G+ S+E + M+ R T+ NM Sbjct: 167 GKWINGKDVALKILGDFKADYFNGMSIEIFVREPSAFPMDFRATVSNM 214
>LEU2_SULSO (Q97VY2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 416 Score = 112 bits (281), Expect = 9e-25 Identities = 73/229 (31%), Positives = 116/229 (50%) Frame = +2 Query: 38 SPMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDRE 217 S T TEKIL+RAS + + PG+ + VD++ HD+ G I + ++ KV+D+ Sbjct: 3 SAKTLTEKILSRASGK-DVSPGDVIEAKVDLVAFHDLTGYHVIEVMEK--ANMIKVFDKS 59 Query: 218 KVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALA 397 K+VI DH D R+ +R F + + I FYDI G+ H + Sbjct: 60 KLVIAFDHLAPPPDVRSAEIQGYIRKFVKSEGIPNFYDIN-----------YGILHEVMI 108 Query: 398 QEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGE 577 ++ + PG+V+L DSHT +GA G FA G+G +D + TGK L VP + VL+G+ Sbjct: 109 EQ-YANPGQVILAADSHTTTSGAVGAFAQGMGASDIAAALITGKTWLVVPQPFKVVLEGK 167 Query: 578 MPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ KD+ L+++G+ ++E S M+ R T+ NM Sbjct: 168 PAKWITGKDVALKLLGDFKADYFNGMTLEIFVKDPLSFPMDYRATVSNM 216
>LEU2_NITEU (Q82WI9) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 470 Score = 112 bits (280), Expect = 1e-24 Identities = 66/210 (31%), Positives = 109/210 (51%) Frame = +2 Query: 95 EPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANR 274 +P V + +D + H+V P K K W ++ + DH + T D + Sbjct: 20 DPNGMVILYIDRHLVHEVTSPQAFESLKLA---GRKPWRTGSILAVADHNVPTTDRSSGI 76 Query: 275 NVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTC 454 + + R Q + + + +++FR N + +G+ H+ ++G PG ++ DSHT Sbjct: 77 SDPVSR--LQVETLDQNCEEFAITEFRMNDERQGIVHVIGPEQGATLPGMTVVCGDSHTS 134 Query: 455 NAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEIS 634 GAF A GIG ++ V+ T + + T+ ++G++PP + AKD+ L +IGEI Sbjct: 135 THGAFACLAFGIGTSEVEHVLATQCLVARKSKTMLVRVEGDLPPGVTAKDIALAVIGEIG 194 Query: 635 VSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +G T ++EF GS I SL+ME RMTLCNM Sbjct: 195 TAGGTGYAIEFAGSAIRSLSMEGRMTLCNM 224
>LEU2_MYCSM (Q938C9) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 422 Score = 109 bits (273), Expect = 8e-24 Identities = 72/224 (32%), Positives = 109/224 (48%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 MT EKILAR + A + GE V V+VD+ + D+ F + + + D KV Sbjct: 3 MTIIEKILARKAGVAEVHAGEIVTVEVDMTVLIDLQ-------FATMWMQPLMINDASKV 55 Query: 224 VIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQE 403 I+ DH + + R F + I+ FYD+ G+CH +A+ Sbjct: 56 AIVMDHAVPAPTIKDAAGGPNARKFANDYGIERFYDV----------GRHGICHQVIAEN 105 Query: 404 GHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMP 583 G RPGE+L TDSHTC GAF A G+G + ++ TG+ + PTIR+ L G MP Sbjct: 106 GLARPGEILACTDSHTCAGGAFNTAARGLGPAEVYSILCTGQTWFQASPTIRYELIGSMP 165 Query: 584 PYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTL 715 + KD+ L I + AT ++E+ G + S+ + +R T+ Sbjct: 166 AGVSGKDVFLYIAD--AFGDATNSNLEYGGPGLASIPLNDRRTI 207
>LEU2_PELUB (Q4FP15) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 467 Score = 109 bits (273), Expect = 8e-24 Identities = 69/208 (33%), Positives = 106/208 (50%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNV 280 VD + H+V P F+ + KV + + DH + T AD + V Sbjct: 27 VDRHLVHEVTSPQA---FEGLRNSNRKVRQPGLTLAVADHNVPTTDRSKGIADAESKIQV 83 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 D L C+E ++Y N +G+ HI ++G +PG V++ DSHT Sbjct: 84 DTLESNCKEFGVQYL---------GMNDKRQGIVHIIGPEQGFTQPGTVIVCGDSHTATH 134 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T + K R ++G++P + +KD+ILQIIG+I + Sbjct: 135 GAFGALAFGIGTSEVEHVLATQTLVQKKAKNFRINVNGKLPIGVTSKDVILQIIGQIGTA 194 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 G T +E+ GS I SL++E+RMT+CNM Sbjct: 195 GGTGSVIEYAGSLISSLSVEQRMTICNM 222
>LEU2_NITOC (Q3J716) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 108 bits (269), Expect = 2e-23 Identities = 71/216 (32%), Positives = 105/216 (48%), Gaps = 7/216 (3%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER---- 265 PG + +D + H+V P F+ K W + + +PDH + T D Sbjct: 20 PGGTALLYIDRHLVHEVTSPQA---FEGLRLAGRKPWRKGANLAVPDHNVPTTDRSQGIQ 76 Query: 266 ---ANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 + V+ L CQE L++FR + +G+ HI ++G PG ++ Sbjct: 77 DPISRIQVEALDRNCQEL---------GLTEFRMDDPRQGIVHIVGPEQGATLPGMTVVC 127 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG ++ V+ T L K + + G++ P + +KDLIL Sbjct: 128 GDSHTATHGAFGALAFGIGTSEVEHVLATQCLLQKKSKNMLIQVSGKLAPGVYSKDLILA 187 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 II I +G T ++EF G TI +L+ME RMTLCNM Sbjct: 188 IIARIGTAGGTGYTIEFAGETIRALSMEGRMTLCNM 223
>LEU2_RHIME (Q92L76) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 106 bits (265), Expect = 6e-23 Identities = 69/206 (33%), Positives = 106/206 (51%), Gaps = 5/206 (2%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D + H+V P + KV EK + + DH + T+ +R ++ I + Sbjct: 29 IDRHLVHEVTSPQAFEGLRMA---GRKVRAPEKTLAVVDHNVPTSPDR---HLGIKNE-- 80 Query: 302 QEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGA 466 E +I+ ++ +DF N +G+ HI ++G PG ++ DSHT GA Sbjct: 81 -ESRIQVEALARNAADFGVEYYSENDKRQGIVHIVGPEQGFTLPGMTIVCGDSHTSTHGA 139 Query: 467 FGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGA 646 FG A GIG ++ V+ T + K + +DG++PP + AKD+IL IIGEI +G Sbjct: 140 FGALAHGIGTSEVEHVLATQTLIQKKAKNMLVRVDGQLPPGVTAKDIILAIIGEIGTAGG 199 Query: 647 TYRSMEFVGSTIESLTMEERMTLCNM 724 T +EF G I SL+ME RMT+CNM Sbjct: 200 TGHVIEFAGEAIRSLSMEGRMTVCNM 225
>LEU2_PSE14 (Q48K99) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 474 Score = 106 bits (265), Expect = 6e-23 Identities = 57/178 (32%), Positives = 97/178 (54%), Gaps = 3/178 (1%) Frame = +2 Query: 200 KVWDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKD---LSDFRANPDY 370 K W + ++ PDH + T ER +D + D +++ D D +++F+ N Sbjct: 51 KPWRIDSIIATPDHNVPTTSERKG-GIDAIEDQVSRLQVQTLDDNCDEYGITEFKMNDPR 109 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T + K Sbjct: 110 QGIVHVIGPEQGATLPGMSVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVAKKMK 169 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + ++G++P + AKD++L +IG+I +G ++EF GS I L++E RMT+CNM Sbjct: 170 NMLVSVEGQLPFGVTAKDIVLAVIGKIGTAGGNGYAIEFAGSAIRDLSIEGRMTICNM 227
>LEU21_DEIRA (Q9RTY9) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 434 Score = 106 bits (264), Expect = 8e-23 Identities = 72/240 (30%), Positives = 120/240 (50%) Frame = +2 Query: 5 GTRPASTGSVKSPMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQE 184 G+ P +T P T EKIL++ A++ G+ V+VD +M D I +++ Sbjct: 10 GSSPQTT----RPQTVAEKILSQRGS-AAVYAGDLAVVEVDQVMVVDSIAQSFIERMERD 64 Query: 185 FGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANP 364 G K E+V I+ DH + + R++ + ++ F D+ Sbjct: 65 LGAVPKY--PERVSIVVDHVAPASTVSVAQAQKEAREYAAKTGVRLF----DVG------ 112 Query: 365 DYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKV 544 +G+CH L +E +PG ++LG+DSH+ GA F +G+G TD +GK L+V Sbjct: 113 --RGICHQVLMEEKLAQPGWIVLGSDSHSTTYGAVAAFGSGMGATDIALAAASGKTWLRV 170 Query: 545 PPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P +++ L G++ P + AKD+ L++I + GATY+S+E + T ERMTL N+ Sbjct: 171 PESVKVTLTGDLRPGVTAKDVALEMIRVLGADGATYQSVEIHAG--DRFTRGERMTLANL 228
>LEU2_PSEPK (Q88LE8) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 477 Score = 106 bits (264), Expect = 8e-23 Identities = 64/203 (31%), Positives = 103/203 (50%), Gaps = 2/203 (0%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D + H+V P F+ + K W + + PDH + T ER I+ Sbjct: 28 IDRHIIHEVTSPQA---FEGLRLANRKPWRIDANIATPDHNVPTTPERKGGIEAIVDQVS 84 Query: 302 --QEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQ 475 Q Q + D + +F+ N + +G+ H+ ++G PG ++ DSHT GAFG Sbjct: 85 RLQVQTLDENCDEYGIVEFKMNDERQGIVHVISPEQGATLPGMTVVCGDSHTSTHGAFGA 144 Query: 476 FATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYR 655 A GIG ++ V+ T + K + ++G++P + AKD++L +IG+I +G Sbjct: 145 LAHGIGTSEVEHVLATQCLVAKKMKNMLVRVEGQLPAGVTAKDIVLAVIGKIGTAGGNGH 204 Query: 656 SMEFVGSTIESLTMEERMTLCNM 724 +MEF GS I L+ME RMT+CNM Sbjct: 205 AMEFAGSAIRELSMEGRMTICNM 227
>HACA_THET2 (Q9ZNE0) Probable homoaconitase large subunit (EC 4.2.1.36)| (Homoaconitate hydratase) Length = 418 Score = 106 bits (264), Expect = 8e-23 Identities = 76/228 (33%), Positives = 119/228 (52%), Gaps = 2/228 (0%) Frame = +2 Query: 47 TTTEKILARASERASLEPGENVWVDVDVLMTHD-VCGPGTIGIFKQEFGEDAKVWDREKV 223 T EKIL+ R + GE V V+VD +M D + G FK+ +A E+V Sbjct: 4 TLAEKILSHKVGRP-VRAGELVVVEVDQVMVVDSIAG----SFFKRLEYLEATPRYPERV 58 Query: 224 VIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQE 403 I+ DH A+ + +R++ + I+ F D+ +GVCH L +E Sbjct: 59 SIVIDHVAPAANLEVAKAQKEIREWGKRHGIRVF----DVG--------RGVCHQVLIEE 106 Query: 404 GHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMP 583 G +PG V++G+DSH+ GA G F TG+G TD +G+ L+VP +++ V G +P Sbjct: 107 GLAQPGWVVVGSDSHSTTYGAVGAFGTGMGATDIALAAASGRTWLRVPESVKVVFRGRLP 166 Query: 584 PYLLAKDLILQIIGEISVSGATYRSMEF-VGSTIESLTMEERMTLCNM 724 + AKD L+++ ++ GATY ++E + E+LT ERMTL N+ Sbjct: 167 KGVTAKDAALEMVRLLTAEGATYMAVEIHLLDGAEALTRGERMTLANL 214
>LEU2_BURMA (Q62AI6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 105 bits (261), Expect = 2e-22 Identities = 67/201 (33%), Positives = 102/201 (50%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D + H+V P K VW + + DH + T D R++ D + Sbjct: 27 IDRQLLHEVTSPQAFEGLKLA---QRPVWRISANLAVSDHNVPTTD-RSHGIADPVSKL- 81 Query: 302 QEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFA 481 Q + D ++ F+ N +G+ HI ++G PG ++ DSHT GAFG A Sbjct: 82 QVDTLDANCDAYGITQFKMNDVRQGIVHIIGPEQGATLPGMTIVCGDSHTSTHGAFGALA 141 Query: 482 TGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSM 661 GIG ++ V+ T L K + ++G++P AKD++L IIG+I +G T ++ Sbjct: 142 HGIGTSEVEHVLATQTLLQKKSKNMLVKVEGQLPRGCTAKDIVLAIIGQIGTAGGTGYAI 201 Query: 662 EFVGSTIESLTMEERMTLCNM 724 EF GSTI +LTME RMT+CNM Sbjct: 202 EFGGSTIRALTMEGRMTVCNM 222
>LEU2_PSESM (Q884C2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 475 Score = 105 bits (261), Expect = 2e-22 Identities = 56/178 (31%), Positives = 97/178 (54%), Gaps = 3/178 (1%) Frame = +2 Query: 200 KVWDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKD---LSDFRANPDY 370 K W + ++ PDH + T ER ++ + D +++ D D +++F+ N Sbjct: 51 KPWRIDSIIATPDHNVPTTSERKG-GIEAIEDQVSRLQVQTLDDNCDEYGITEFKMNDPR 109 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T + K Sbjct: 110 QGIVHVIGPEQGATLPGMSVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVAKKMK 169 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + ++G++P + AKD++L +IG+I +G ++EF GS I L++E RMT+CNM Sbjct: 170 NMLVSVEGQLPFGVTAKDIVLAVIGKIGTAGGNGYAIEFAGSAIRDLSIEGRMTICNM 227
>LEU22_BRAJA (Q89X34) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 468 Score = 104 bits (260), Expect = 2e-22 Identities = 67/208 (32%), Positives = 103/208 (49%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADE-------RANRNV 280 +D + H+V P F+ KV EK + + DH + T D + + Sbjct: 29 IDRHLVHEVTSPQA---FEGLRATGRKVHAPEKTLAVVDHNVPTTDRTKPNPDPESIEQI 85 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 L D +E I+Y+ + D R +G+ H+ ++G PG ++ DSHT Sbjct: 86 KALADNAREFGIEYYNEF----DKR-----QGIVHVIGPEQGFTLPGTTIVCGDSHTSTH 136 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T + K +R +DG++P + KD+IL IIGEI + Sbjct: 137 GAFGALAHGIGTSEVEHVLATQTLIQKKAKNMRVTVDGKLPDGVTGKDIILAIIGEIGTA 196 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 G T +E+ G I +L+ME RMT+CNM Sbjct: 197 GGTGYVLEYAGEAIRALSMEGRMTVCNM 224
>LEU2_BURPS (Q63JK9) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 104 bits (259), Expect = 3e-22 Identities = 67/201 (33%), Positives = 101/201 (50%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D + H+V P K VW + + DH + T D R++ D + Sbjct: 27 IDRQLLHEVTSPQAFEGLKLA---QRPVWRISANLAVSDHNVPTTD-RSHGIADPVSKL- 81 Query: 302 QEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFA 481 Q + D ++ F+ N +G+ HI ++G PG ++ DSHT GAFG A Sbjct: 82 QVDTLDANCDAYGITQFKMNDVRQGIVHIIGPEQGATLPGMTIVCGDSHTSTHGAFGALA 141 Query: 482 TGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSM 661 GIG ++ V+ T L K + ++G++P AKD++L IIG I +G T ++ Sbjct: 142 HGIGTSEVEHVLATQTLLQKKSKNMLVKVEGQLPRGCTAKDIVLAIIGRIGTAGGTGYAI 201 Query: 662 EFVGSTIESLTMEERMTLCNM 724 EF GSTI +LTME RMT+CNM Sbjct: 202 EFGGSTIRALTMEGRMTVCNM 222
>LEU2_RHOPA (Q6ND69) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 103 bits (258), Expect = 4e-22 Identities = 69/203 (33%), Positives = 103/203 (50%), Gaps = 2/203 (0%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D + H+V P F+ KV EK + + DH + T D R+ N D Sbjct: 30 IDRHLVHEVTSPQA---FEGLRTAGRKVHAPEKTLAVVDHNVPTTD-RSKPNPD---PES 82 Query: 302 QEQKIKYFYDIKD--LSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQ 475 EQ + +D ++ + +GV H+ ++G PG ++ DSHT GAFG Sbjct: 83 AEQIAALAENARDFGITYYNEFDKRQGVVHVIGPEQGFTLPGTTIVCGDSHTSTHGAFGA 142 Query: 476 FATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYR 655 A GIG ++ V+ T + K +R +DG++P + AKD+IL IIGEI +G T Sbjct: 143 LAHGIGTSEVEHVLATQTLIQKKAKNMRVTVDGQLPDGVTAKDVILAIIGEIGTAGGTGY 202 Query: 656 SMEFVGSTIESLTMEERMTLCNM 724 +E+ G I SL+ME RMT+CNM Sbjct: 203 VLEYAGDAIRSLSMEGRMTVCNM 225
>LEU2_SYMTH (Q67MJ2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 481 Score = 103 bits (257), Expect = 5e-22 Identities = 76/233 (32%), Positives = 112/233 (48%), Gaps = 4/233 (1%) Frame = +2 Query: 38 SPMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGP----GTIGIFKQEFGEDAKV 205 S T +KI R R EPG+ + +D+ + H+V P G ++ D + Sbjct: 9 SGRTLLDKIWERHVVRR--EPGKPDLLYIDLHLVHEVTSPQAFEGLRMAGRRVRRPDLTI 66 Query: 206 WDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCH 385 + V D + DE A R + L C E ++ F DL ++G+ H Sbjct: 67 ATMDHNVPTTDRSLPLTDEIAARQMAALERNCSEFGVRLF----DLYS-----PFQGIVH 117 Query: 386 IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFV 565 + + G +PG ++ DSHT GAFG A GIG ++ V+ T P + Sbjct: 118 VIGPELGLTQPGLTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQCLWQHKPKVMEIR 177 Query: 566 LDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++G++PP AKDLIL IIG+I GAT +E+ G I SL+ME RMT+CNM Sbjct: 178 VNGKLPPGTTAKDLILGIIGQIGTDGATGYVIEYTGEAIRSLSMEGRMTVCNM 230
>LEU2_NITWN (Q3SNV3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 468 Score = 103 bits (257), Expect = 5e-22 Identities = 65/202 (32%), Positives = 103/202 (50%), Gaps = 1/202 (0%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADE-RANRNVDILRDF 298 +D + H+V P F+ KV EK + + DH + T D + N + + Sbjct: 29 IDRHLVHEVTSPQA---FEGLRVAGRKVHAPEKTLAVVDHNVPTTDRSKPNPDPESAEQI 85 Query: 299 CQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQF 478 + + I+ ++F +G+ H+ ++G PG ++ DSHT GAFG Sbjct: 86 AALAQNARDFGIEYYNEFDKR---QGIVHVIGPEQGFTLPGTTIVCGDSHTSTHGAFGAL 142 Query: 479 ATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRS 658 A GIG ++ V+ T + K +R V+DG++P + AKD+IL IIGEI +G T Sbjct: 143 AHGIGTSEVEHVLATQTLIQKKAKNMRAVVDGKLPDGVTAKDIILAIIGEIGTAGGTGYV 202 Query: 659 MEFVGSTIESLTMEERMTLCNM 724 +E+ G I +L+ME RMT+CNM Sbjct: 203 LEYAGEAIRALSMEGRMTVCNM 224
>LEU2_USTMA (P49601) 3-isopropylmalate dehydratase (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 773 Score = 103 bits (256), Expect = 7e-22 Identities = 76/237 (32%), Positives = 114/237 (48%), Gaps = 8/237 (3%) Frame = +2 Query: 38 SPMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDRE 217 +P T EKI S E + +D + H+V P F+ + KV + Sbjct: 2 APKTLYEKIFD--SHLVHEEADGTCLIYIDRHLVHEVTSPQA---FEGLRNANRKVRRTD 56 Query: 218 KVVIIPDHYIFTADERANRNVDIL------RDFCQ--EQKIKYFYDIKDLSDFRANPDYK 373 + DH I TA ++ R+ R C E+ +K F L+ F + + + Sbjct: 57 CTLATVDHNIPTASRKSYRDTKSFVEQVDSRTQCMTLEENVKAF----GLTFFGLSDNRQ 112 Query: 374 GVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPT 553 G+ HI ++G PG ++ DSHT GAFG A GIG ++ V+ T L K Sbjct: 113 GIVHIIGPEQGFTLPGATIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLLQKRAKN 172 Query: 554 IRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + +DGE+ + +KD+IL IIG I +G T +E+ GSTI SL+ME RM++CNM Sbjct: 173 MLIQVDGELSQGVTSKDIILHIIGLIGTAGGTGHVIEYAGSTIRSLSMEARMSICNM 229
>LEU2_PSEU2 (Q4ZUZ6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 474 Score = 103 bits (256), Expect = 7e-22 Identities = 56/178 (31%), Positives = 96/178 (53%), Gaps = 3/178 (1%) Frame = +2 Query: 200 KVWDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKD---LSDFRANPDY 370 K W + ++ PDH + T ER + + D +++ D D +++F+ N Sbjct: 51 KPWRIDSIIATPDHNVPTTAERKG-GIGAIEDQVSRLQVQTLDDNCDEYGITEFKMNDPR 109 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T + K Sbjct: 110 QGIVHVIGPEQGATLPGMSVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVAKKMK 169 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + ++G++P + AKD++L +IG+I +G ++EF GS I L++E RMT+CNM Sbjct: 170 NMLVSVEGQLPFGVTAKDIVLAVIGKIGTAGGNGYAIEFAGSAIRDLSIEGRMTICNM 227
>LEU2_CANMA (Q00464) 3-isopropylmalate dehydratase (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 770 Score = 102 bits (255), Expect = 9e-22 Identities = 53/140 (37%), Positives = 79/140 (56%) Frame = +2 Query: 305 EQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFAT 484 EQ +K F D++ F D +G+ H+ ++G PG ++ DSHT GAFG A Sbjct: 94 EQNVKDF----DVTYFGMTDDRQGIVHVVGPEQGFTLPGTTVVCGDSHTSTHGAFGALAF 149 Query: 485 GIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSME 664 GIG ++ V+ T + P +R +DGE+ + +KDL+L +IG I +G T +E Sbjct: 150 GIGTSEVEHVLATQTTIQANPKNMRITIDGELSEGITSKDLVLHVIGVIGTAGGTGCVIE 209 Query: 665 FVGSTIESLTMEERMTLCNM 724 F G IE L+ME RM++CNM Sbjct: 210 FAGKAIEDLSMEARMSICNM 229
>LEU2_RHILO (Q98EF1) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 102 bits (254), Expect = 1e-21 Identities = 67/209 (32%), Positives = 106/209 (50%), Gaps = 8/209 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER--------ANRN 277 +D + H+V P F+ KV EK + + DH + T+ ER + Sbjct: 29 IDRHLVHEVTSPQA---FEGLRLSGRKVRHPEKTLAVVDHNVSTSPERKFGIKNEESRIQ 85 Query: 278 VDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCN 457 V+ L ++ ++Y+ + +D R +G+ HI ++G PG ++ DSHT Sbjct: 86 VEALAKNAKDFGVEYYSE----NDIR-----QGIVHIIGPEQGFTLPGMTIVCGDSHTST 136 Query: 458 AGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISV 637 GAFG A GIG ++ V+ T + + + +DG++P + AKD+IL IIGEI Sbjct: 137 HGAFGALAHGIGTSEVEHVLATQTLIQRKAKNMLVRVDGQLPEGVTAKDIILAIIGEIGT 196 Query: 638 SGATYRSMEFVGSTIESLTMEERMTLCNM 724 +G T +E+ G I SL+ME RMT+CNM Sbjct: 197 AGGTGYVIEYAGEAIRSLSMEGRMTICNM 225
>LEU2_BUCUS (Q9EVI3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Fragment) Length = 442 Score = 102 bits (254), Expect = 1e-21 Identities = 67/208 (32%), Positives = 104/208 (50%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER-------ANRNV 280 +D+ + H+V P + + KV K DH + T + A + + Sbjct: 27 IDLHLLHEVTSPQAFDALRNK---QRKVRQSRKTFATMDHNVSTTIQNISASGSMAQKQM 83 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 + L CQE I YDI NP+ +G+ H+ ++G PG ++ DSHT Sbjct: 84 EQLIKNCQEFNIP-LYDIN-------NPN-QGIVHVIAPEKGMTLPGMTIVCGDSHTSTH 134 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T K ++ + GE+P ++ AKD+IL IIG++ S Sbjct: 135 GAFGALAFGIGTSEVEHVLATQTLKQKRFKNMKIEIIGEIPKFVTAKDIILFIIGKLGSS 194 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 T +EF G I++++MEERMT+CNM Sbjct: 195 SGTGYVIEFCGDVIKNMSMEERMTICNM 222
>LEU2_BUCUA (Q9EVG5) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Fragment) Length = 443 Score = 101 bits (252), Expect = 2e-21 Identities = 66/208 (31%), Positives = 105/208 (50%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNV 280 +D+ + H+V P + + KV +K DH + T + A + + Sbjct: 27 IDLHLLHEVTSPQAFNALRNK---KRKVRQSKKTFATMDHNVSTKIRSIHASGSMAQKQM 83 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 + L + C E I YDI NP+ +G+ H+ ++G PG ++ DSHT Sbjct: 84 EQLINNCTEFNIP-LYDIN-------NPN-QGIVHVIAPEKGMTLPGMTIVCGDSHTSTH 134 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T K ++ + GEMP ++ AKD+IL IIG++ S Sbjct: 135 GAFGTLAFGIGTSEVEHVLATQTLKQKRFKNMKVEIIGEMPKFVTAKDIILFIIGKLGSS 194 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 +EF G+ I++++MEERMT+CNM Sbjct: 195 SGAGHVIEFCGNVIKNMSMEERMTICNM 222
>LEU2_RALEJ (Q46YV7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 101 bits (252), Expect = 2e-21 Identities = 67/208 (32%), Positives = 100/208 (48%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNV 280 +D + H+V P K + VW + + DH + T AD + V Sbjct: 27 IDRHLLHEVTSPQAFEGLKIA---ERPVWRISANLAVSDHNVPTTDRSEGIADPVSKLQV 83 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 D L C D ++ F+ N +G+ H+ ++G PG ++ DSHT Sbjct: 84 DTLDANC---------DSFGITQFKMNDHRQGIVHVIGPEQGATLPGMTVVCGDSHTSTH 134 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T L K + ++G++P AKD++L IIG+I + Sbjct: 135 GAFGALAHGIGTSEVEHVLATQTLLGKKAKNMLVKVEGKLPRGCTAKDIVLAIIGKIGTA 194 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 G T ++EF GS I LTME RMT+CNM Sbjct: 195 GGTGYTIEFAGSAIRDLTMEGRMTVCNM 222
>LEU2_XANCP (P58949) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 479 Score = 101 bits (252), Expect = 2e-21 Identities = 54/178 (30%), Positives = 94/178 (52%), Gaps = 3/178 (1%) Frame = +2 Query: 200 KVWDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKD---LSDFRANPDY 370 K W + + PDH + T ++ + D +++ + D + +F+ N Sbjct: 51 KPWRIDANIATPDHNVPTTRAERQGGLESISDEVSRLQVQTLDENCDDFGILEFKMNDTR 110 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T + K Sbjct: 111 QGIVHVVGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLIAKKMK 170 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ ++G +P + AKD++L +IG+I +G ++EF GS I +L+ME RMT+CNM Sbjct: 171 NLQVRVEGTLPFGVTAKDIVLAVIGKIGTAGGNGHALEFAGSAIRALSMEGRMTICNM 228
>LEU2_XANC8 (Q4UYG5) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 479 Score = 101 bits (252), Expect = 2e-21 Identities = 54/178 (30%), Positives = 94/178 (52%), Gaps = 3/178 (1%) Frame = +2 Query: 200 KVWDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKD---LSDFRANPDY 370 K W + + PDH + T ++ + D +++ + D + +F+ N Sbjct: 51 KPWRIDANIATPDHNVPTTRAERQGGLESISDEVSRLQVQTLDENCDDFGILEFKMNDTR 110 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T + K Sbjct: 111 QGIVHVVGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLIAKKMK 170 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ ++G +P + AKD++L +IG+I +G ++EF GS I +L+ME RMT+CNM Sbjct: 171 NLQVRVEGTLPFGVTAKDIVLAVIGKIGTAGGNGHALEFAGSAIRALSMEGRMTICNM 228
>LEU2_LEPIN (Q8F4E6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 465 Score = 101 bits (251), Expect = 3e-21 Identities = 70/208 (33%), Positives = 104/208 (50%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNV 280 +D + H+V P K KV E DH + T AD + + Sbjct: 26 IDRHLIHEVTSPQAFEGLKLA---GRKVRRPEATFATMDHNVSTRTRDLSLADPVSAIQM 82 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 L+ C E I+ + DF+ NPD +G+ H+ + G PG ++ DSHT Sbjct: 83 QTLKKNCDENGIRVY-------DFQ-NPD-QGIIHVIAPEMGLTHPGMTIVCGDSHTSTH 133 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T + K T+ +DG++ + AKD+IL IIG+I + Sbjct: 134 GAFGALAFGIGTSEVEHVLATQTLVQKRAKTMEIRVDGKLSDKVTAKDIILAIIGKIGTA 193 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 GAT +E+ GS I++L+ME RMT+CNM Sbjct: 194 GATGYVIEYRGSAIQALSMEARMTICNM 221
>LEU2_LEPIC (Q72RC4) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 465 Score = 101 bits (251), Expect = 3e-21 Identities = 70/208 (33%), Positives = 104/208 (50%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNV 280 +D + H+V P K KV E DH + T AD + + Sbjct: 26 IDRHLIHEVTSPQAFEGLKLA---GRKVRRPEATFATMDHNVSTRTRDLSLADPVSAIQM 82 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 L+ C E I+ + DF+ NPD +G+ H+ + G PG ++ DSHT Sbjct: 83 QTLKKNCDENGIRVY-------DFQ-NPD-QGIIHVIAPEMGLTHPGMTIVCGDSHTSTH 133 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T + K T+ +DG++ + AKD+IL IIG+I + Sbjct: 134 GAFGALAFGIGTSEVEHVLATQTLVQKRAKTMEIRVDGKLSDKVTAKDIILAIIGKIGTA 193 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 GAT +E+ GS I++L+ME RMT+CNM Sbjct: 194 GATGYVIEYRGSAIQALSMEARMTICNM 221
>LEU2_XANAC (P58948) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 479 Score = 100 bits (250), Expect = 3e-21 Identities = 54/178 (30%), Positives = 94/178 (52%), Gaps = 3/178 (1%) Frame = +2 Query: 200 KVWDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKD---LSDFRANPDY 370 K W + + PDH + T ++ + D +++ + D + +F+ N Sbjct: 51 KPWRIDANIATPDHNVPTTRAERQGGLESISDEVSRLQVQTLDENCDDFGILEFKMNDAR 110 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T + K Sbjct: 111 QGIVHVVGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLIAKKMK 170 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ ++G +P + AKD++L +IG+I +G ++EF GS I +L+ME RMT+CNM Sbjct: 171 NMQVRVEGTLPFGVTAKDIVLAVIGKIGTAGGNGHALEFAGSAIRTLSMEGRMTICNM 228
>LEU2_SCHPO (O14289) 3-isopropylmalate dehydratase (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 758 Score = 100 bits (250), Expect = 3e-21 Identities = 74/236 (31%), Positives = 116/236 (49%), Gaps = 4/236 (1%) Frame = +2 Query: 29 SVKSPMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVW 208 SV SP T +K+ S L+ + +D + H+V P F+ KV Sbjct: 4 SVASPKTLYDKVWD--SHVVDLQEDGTCLLYIDRHLIHEVTSPQA---FEGLRTAGRKVR 58 Query: 209 DREKVVIIPDHYIFTADERANRNVD--ILRDFCQEQKIKYFYDIKD--LSDFRANPDYKG 376 E + DH I T + +++ I + + Q + +IK+ L+ + N +G Sbjct: 59 HPELALATVDHNIPTDPRKDMKDIASFIHQPDSRTQVLALENNIKEFGLTYYGMNDRRQG 118 Query: 377 VCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTI 556 + H+ ++G PG L+ DSHT GAFG A GIG ++ V+ T L + + Sbjct: 119 IVHVIGPEQGFTLPGTTLVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTILQRKSKNM 178 Query: 557 RFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 R ++G++P + +KDLIL IIG I +G T +EF G IE L+ME RM++CNM Sbjct: 179 RIRVNGKLPEGIASKDLILHIIGVIGTAGGTGSVIEFCGEAIEGLSMEARMSMCNM 234
>LEU2_BRUME (Q8YJC9) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 100 bits (249), Expect = 5e-21 Identities = 65/206 (31%), Positives = 103/206 (50%), Gaps = 5/206 (2%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D + H+V P F+ V EK + + DH + T+ +R N + Sbjct: 29 IDRHLVHEVTSPQA---FEGLHMAGRPVRHPEKTLAVVDHNVPTSPDRINGIQN------ 79 Query: 302 QEQKIKYFYDIKDLSDFRAN-----PDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGA 466 +E +I+ ++ +DF +G+ HI ++G PG ++ DSHT GA Sbjct: 80 EESRIQVEALARNAADFGVEYYSERDKRQGIVHIVGPEQGFTLPGMTIVCGDSHTSTHGA 139 Query: 467 FGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGA 646 FG A GIG ++ V+ T + K + +DG++P + AKD++L IIGEI +G Sbjct: 140 FGALAHGIGTSEVEHVLATQTLIQKKAKNMLVRVDGKLPAGVTAKDIVLAIIGEIGTAGG 199 Query: 647 TYRSMEFVGSTIESLTMEERMTLCNM 724 T +E+ G I SL+ME RMT+CNM Sbjct: 200 TGYVIEYAGEAIRSLSMEGRMTICNM 225
>LEU2_CAUCR (Q9ABN0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 479 Score = 100 bits (249), Expect = 5e-21 Identities = 67/220 (30%), Positives = 103/220 (46%), Gaps = 10/220 (4%) Frame = +2 Query: 95 EPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT------- 253 E G + +D+ + H+V P + KV ++ + + DH I T Sbjct: 18 EAGGEAILYIDLHLIHEVTTPQAFAGLR---AAGRKVRRPDRTLAVADHNIPTEGQALGV 74 Query: 254 ---ADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGE 424 ADE A + L + I++F + D R G+ H+ ++G +PG Sbjct: 75 DAVADEEARLQLKTLARNVADNGIEFF----PMGDIR-----NGIVHVVGPEQGRTQPGM 125 Query: 425 VLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKD 604 ++ DSHT GAFG A GIG ++ V+ T K + +DG++PP + KD Sbjct: 126 TIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLRQKKAKNMLVRVDGQLPPGVTGKD 185 Query: 605 LILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + L +IGEI +G T +EF G I L+ME RMTLCN+ Sbjct: 186 VALAVIGEIGTAGGTGYVIEFAGEAIAGLSMEGRMTLCNL 225
>LEU2_BRUSU (Q8FYG9) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 100 bits (248), Expect = 6e-21 Identities = 59/175 (33%), Positives = 93/175 (53%), Gaps = 5/175 (2%) Frame = +2 Query: 215 EKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRAN-----PDYKGV 379 EK + + DH + T+ +R N + +E +I+ ++ +DF +G+ Sbjct: 57 EKTLAVVDHNVPTSPDRINGIQN------EESRIQVEALARNAADFGVEYYSERDKRQGI 110 Query: 380 CHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIR 559 HI ++G PG ++ DSHT GAFG A GIG ++ V+ T + K + Sbjct: 111 VHIVGPEQGFTLPGMTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLIQKKAKNML 170 Query: 560 FVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +DG++P + AKD++L IIGEI +G T +E+ G I SL+ME RMT+CNM Sbjct: 171 VRVDGKLPAGVTAKDIVLAIIGEIGTAGGTGYVIEYAGEAIRSLSMEGRMTICNM 225
>LEU2_XANOR (Q5H4D1) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 482 Score = 100 bits (248), Expect = 6e-21 Identities = 53/176 (30%), Positives = 93/176 (52%), Gaps = 3/176 (1%) Frame = +2 Query: 206 WDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKD---LSDFRANPDYKG 376 W + + PDH + T ++ + D +++ + D + +F+ N +G Sbjct: 53 WRIDANIATPDHNVPTTRAERQGGLESISDEVSRLQVQTLDENCDDFGILEFKMNDARQG 112 Query: 377 VCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTI 556 + H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T + K + Sbjct: 113 IVHVVGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLITKKMKNL 172 Query: 557 RFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + ++G +P + AKD++L +IG+I +G ++EF GS I +L+ME RMT+CNM Sbjct: 173 QVRVEGTLPFGVTAKDIVLAVIGKIGTAGGNGHALEFAGSAIRALSMEGRMTICNM 228
>LEU2_BUCUN (Q9EVI6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Fragment) Length = 443 Score = 99.8 bits (247), Expect = 8e-21 Identities = 64/208 (30%), Positives = 102/208 (49%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNV 280 +D+ + H+V P + + V +K DH + T + A + + Sbjct: 27 IDLHLLHEVTSPQAFDSLRNK---QRTVRQSKKTFATMDHNVSTKIQNISASGSMAQKQM 83 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 + L CQE I YDI N ++G+ H+ ++G PG ++ DSHT Sbjct: 84 EQLIQNCQEFNIP-LYDI--------NNPHQGIVHVIAPEKGMTLPGMTIVCGDSHTSTH 134 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T K ++ + G++P ++ AKD+IL IIG++ S Sbjct: 135 GAFGALAFGIGTSEVEHVLATQTLKQKRFKNMKIEIIGKIPRFVTAKDIILFIIGKLGSS 194 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 T +EF G I +++MEERMT+CNM Sbjct: 195 SGTGHVIEFCGDVIRNMSMEERMTICNM 222
>LEU2_BUCAI (P56934) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 471 Score = 99.8 bits (247), Expect = 8e-21 Identities = 64/207 (30%), Positives = 105/207 (50%), Gaps = 6/207 (2%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D+ + H+V P + + + KV +K DH + T + N + + + Sbjct: 27 IDLHLLHEVTSPQAFDSLRDK---NRKVRQPKKTFATMDHNVSTTSQDINASGSMAKVQM 83 Query: 302 QEQKIKYFYDIKDLSDFRA------NPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAG 463 QE IK+ S+F NP+ +G+ H+ ++G PG ++ DSHT G Sbjct: 84 QEL-------IKNCSEFNISLYDIKNPN-QGIVHVISPEKGMTLPGMTIVCGDSHTSTHG 135 Query: 464 AFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSG 643 AFG + GIG ++ V+ T + ++ + GE+ ++ AKDLIL IIG++ SG Sbjct: 136 AFGALSFGIGTSEVEHVLATQTLKQQRFKNMKIEITGEIQKFVTAKDLILFIIGKLGSSG 195 Query: 644 ATYRSMEFVGSTIESLTMEERMTLCNM 724 +EF G+ IE ++MEERMT+CNM Sbjct: 196 GAGYIIEFCGNVIEKMSMEERMTICNM 222
>LEU2_STRAW (Q82JR8) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 477 Score = 99.8 bits (247), Expect = 8e-21 Identities = 72/215 (33%), Positives = 101/215 (46%), Gaps = 7/215 (3%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------AD 259 GE + +D+ + H+V P +Q G + D + DH T AD Sbjct: 20 GEPDLLFIDLHLLHEVTSPQAFDGLRQA-GRPVRRLDL--TIATEDHNTPTLDIDKPIAD 76 Query: 260 ERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGT 439 + ++ LR C E ++ + L D +GV H+ Q G +PG ++ Sbjct: 77 PVSRAQLETLRKNCAEFGVR----LHSLGDVE-----QGVVHVVGPQLGLTQPGTTVVCG 127 Query: 440 DSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQI 619 DSHT GAFG A GIG + V+ T L P T+ +DGE+P + AKDLIL I Sbjct: 128 DSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPKTMAITVDGELPDGVTAKDLILAI 187 Query: 620 IGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 I I G +E+ GS IE L+ME RMT+CNM Sbjct: 188 IARIGTGGGQGYILEYRGSAIEKLSMEARMTICNM 222
>LEU2_PSEF5 (Q4KF08) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 472 Score = 99.8 bits (247), Expect = 8e-21 Identities = 56/178 (31%), Positives = 94/178 (52%), Gaps = 3/178 (1%) Frame = +2 Query: 200 KVWDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKD---LSDFRANPDY 370 K W + + PDH + T ER ++ + D +++ D D + +F+ N Sbjct: 51 KPWRIDANIATPDHNVPTTPERKG-GIEAIADQVSRLQVQTLDDNCDEYGIVEFKMNDVR 109 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T + K Sbjct: 110 QGIVHVIGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVAKKMK 169 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + ++G +P + AKD++L +IG+I +G ++EF GS I L++E RMT+CNM Sbjct: 170 NMLVRVEGTLPFGVTAKDIVLAVIGKIGTAGGNGHAIEFAGSAIRELSVEGRMTICNM 227
>LEU2_BORPE (Q7VY75) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 467 Score = 99.8 bits (247), Expect = 8e-21 Identities = 57/156 (36%), Positives = 86/156 (55%) Frame = +2 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 D + VD L D C + I ++FR N +G+ H+ ++G PG ++ Sbjct: 76 DPISRLQVDTLDDNCAKYGI---------TEFRMNDLRQGIVHVIGPEQGATLPGMTVVC 126 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GA G A GIG ++ V+ T L+K +++ ++GE+P AKD++L Sbjct: 127 GDSHTSTHGALGALAFGIGTSEVEHVLATQTLLMKKAKSMQINVEGELPFGCTAKDVVLH 186 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 IIG I +G T ++EF GSTI L++E RMT+CNM Sbjct: 187 IIGIIGTAGGTGHAIEFSGSTIRGLSVEGRMTVCNM 222
>LEU2_BORPA (Q7W931) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 467 Score = 99.8 bits (247), Expect = 8e-21 Identities = 57/156 (36%), Positives = 86/156 (55%) Frame = +2 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 D + VD L D C + I ++FR N +G+ H+ ++G PG ++ Sbjct: 76 DPISRLQVDTLDDNCAKYGI---------TEFRMNDLRQGIVHVIGPEQGATLPGMTVVC 126 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GA G A GIG ++ V+ T L+K +++ ++GE+P AKD++L Sbjct: 127 GDSHTSTHGALGALAFGIGTSEVEHVLATQTLLMKKAKSMQINVEGELPFGCTAKDVVLH 186 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 IIG I +G T ++EF GSTI L++E RMT+CNM Sbjct: 187 IIGIIGTAGGTGHAIEFSGSTIRGLSVEGRMTVCNM 222
>LEU2_BORBR (Q7WKH6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 467 Score = 99.8 bits (247), Expect = 8e-21 Identities = 57/156 (36%), Positives = 86/156 (55%) Frame = +2 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 D + VD L D C + I ++FR N +G+ H+ ++G PG ++ Sbjct: 76 DPISRLQVDTLDDNCAKYGI---------TEFRMNDLRQGIVHVIGPEQGATLPGMTVVC 126 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GA G A GIG ++ V+ T L+K +++ ++GE+P AKD++L Sbjct: 127 GDSHTSTHGALGALAFGIGTSEVEHVLATQTLLMKKAKSMQINVEGELPFGCTAKDVVLH 186 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 IIG I +G T ++EF GSTI L++E RMT+CNM Sbjct: 187 IIGIIGTAGGTGHAIEFSGSTIRGLSVEGRMTVCNM 222
>LEU2_BUCUO (Q9EVI0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Fragment) Length = 443 Score = 99.4 bits (246), Expect = 1e-20 Identities = 65/208 (31%), Positives = 104/208 (50%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNV 280 +D+ + H+V P + + KV K DH + T + A + + Sbjct: 27 IDLHLLHEVTSPQAFDSLRNK---KRKVRQVNKTFATMDHNVSTQIKNINASGSMAKKQM 83 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 + L CQE I YDI NP+ +G+ H+ ++G PG ++ DSHT Sbjct: 84 EQLIKNCQEFNIS-LYDIN-------NPN-QGIVHVIAPEKGMTLPGMTIVCGDSHTSTH 134 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG + GIG ++ V+ T K ++ + GE+P ++ AKD+IL IIG++ S Sbjct: 135 GAFGALSFGIGTSEVEHVLATQTLKQKRFKNMKIEIVGEIPKFVTAKDIILFIIGKLGSS 194 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 T +EF G+ ++ ++MEERMT+CNM Sbjct: 195 SGTGYVIEFCGNVVKKMSMEERMTVCNM 222
>LEU2_RALSO (Q8XXX3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 99.4 bits (246), Expect = 1e-20 Identities = 64/201 (31%), Positives = 100/201 (49%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D + H+V P K + VW + + DH + T D R++ D + Sbjct: 27 IDRQLLHEVTSPQAFEGLKLA---NRPVWRISANLAVSDHNVPTTD-RSHGIADPVSKL- 81 Query: 302 QEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFA 481 Q + D ++ F+ +G+ H+ ++G PG ++ DSHT GAFG A Sbjct: 82 QVDTLDANCDSFGITQFKMTDKRQGIVHVIGPEQGATLPGMTVVCGDSHTSTHGAFGALA 141 Query: 482 TGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSM 661 GIG ++ V+ T L K + ++G +P AKD++L IIG+I +G T +M Sbjct: 142 HGIGTSEVEHVLATQTLLAKKSKNMLVKVEGTLPRGCTAKDIVLAIIGKIGTAGGTGYAM 201 Query: 662 EFVGSTIESLTMEERMTLCNM 724 EF GS I +L+ME RMT+CNM Sbjct: 202 EFGGSAIRALSMEGRMTVCNM 222
>LEU2_BUCUD (Q9EVE0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Fragment) Length = 444 Score = 99.4 bits (246), Expect = 1e-20 Identities = 65/208 (31%), Positives = 106/208 (50%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER-------ANRNV 280 +D+ + H+V P + + E V +K DH + T + A + + Sbjct: 28 IDLHLLHEVTSPQAFDALRSKKRE---VRQSKKTFATMDHNVSTTIQNISASGSMARKQM 84 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 + L CQE I YDI NP+ +G+ H+ ++G PG ++ DSHT Sbjct: 85 EQLIKNCQEFNIP-LYDIN-------NPN-QGIVHVIAPEKGMTLPGMTIVCGDSHTSTH 135 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T K ++ + G++P ++ AKD+IL +IG++ S Sbjct: 136 GAFGALAFGIGTSEVEHVLATQTLKQKRFKNMKIEIIGKIPKFVTAKDIILFVIGQLGSS 195 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 T +EF G+ I++++MEERMT+CNM Sbjct: 196 SGTGYVIEFCGNIIKNMSMEERMTVCNM 223
>LEU2_GLOVI (Q7NFV7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 473 Score = 99.4 bits (246), Expect = 1e-20 Identities = 66/204 (32%), Positives = 98/204 (48%), Gaps = 7/204 (3%) Frame = +2 Query: 134 MTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNVDILR 292 + H+V P + ++ V E+ V DH + T AD A + + L Sbjct: 34 LIHEVTSPQAFAMLRER---GLGVLYAERTVATVDHIVPTQSQQRPFADTLAEQMIRALE 90 Query: 293 DFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFG 472 D C E I+ FY+I S +G+ H+ ++G +PG + DSHT GAFG Sbjct: 91 DNCAEFGIR-FYNIGSGS--------QGIVHVIAPEQGFTQPGMTIACGDSHTATHGAFG 141 Query: 473 QFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATY 652 A GIG + V+ T L R ++G + P + AKD+IL II ++ V Sbjct: 142 AIAFGIGTSQVRDVLATQTLALDKLKVRRIEMNGSLHPGVFAKDVILHIIRKLGVKAGVG 201 Query: 653 RSMEFVGSTIESLTMEERMTLCNM 724 + EF G+T E++ MEERMT+CNM Sbjct: 202 YAYEFAGTTFEAMNMEERMTVCNM 225
>LEU2_XANC5 (Q3BPJ6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 482 Score = 99.4 bits (246), Expect = 1e-20 Identities = 53/178 (29%), Positives = 93/178 (52%), Gaps = 3/178 (1%) Frame = +2 Query: 200 KVWDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKD---LSDFRANPDY 370 K W + + PDH + T ++ + D +++ + D + +F+ N Sbjct: 51 KPWRIDANIATPDHNVPTTRAERQGGLESISDEVSRLQVQTLDENCDDFGILEFKMNDTR 110 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T + K Sbjct: 111 QGIVHVVGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLIAKKMK 170 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ ++G +P + AKD++L +IG+I +G ++EF GS I + +ME RMT+CNM Sbjct: 171 NMQVRVEGTLPFGVTAKDIVLAVIGKIGTAGGNGHALEFAGSAIRAASMEGRMTICNM 228
>LEU21_MANSM (Q65VS0) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 475 Score = 99.4 bits (246), Expect = 1e-20 Identities = 60/210 (28%), Positives = 108/210 (51%), Gaps = 4/210 (1%) Frame = +2 Query: 107 NVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVD- 283 NV + +D + ++ P ++E + VW+++ +++ DH T R D Sbjct: 27 NVLLYIDRTILNEYTSPQAFSGLREE---NRDVWNKKSILLNVDHVNPTRPVRDANMTDP 83 Query: 284 ---ILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTC 454 + ++ +E + ++ D++D R +G+ H+ ++G PG V+ DSHT Sbjct: 84 GGTLQVNYFRENSKLFDIELFDVTDPR-----QGIEHVVAHEQGLALPGMVIAAGDSHTT 138 Query: 455 NAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEIS 634 GAFG F GIG ++ ++ T + K +R L G++P AKD+I+ ++ +I Sbjct: 139 TYGAFGAFGFGIGTSEIEHLLATQTLVYKKLKNMRVTLTGKLPFGTTAKDVIMALVAKIG 198 Query: 635 VSGATYRSMEFVGSTIESLTMEERMTLCNM 724 GAT ++EF G I+ L++E RMT+CNM Sbjct: 199 ADGATNYAIEFCGEVIDELSVEGRMTICNM 228
>LEU2_OCEIH (Q8EN69) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 468 Score = 99.0 bits (245), Expect = 1e-20 Identities = 76/237 (32%), Positives = 115/237 (48%), Gaps = 6/237 (2%) Frame = +2 Query: 32 VKSPMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWD 211 ++ P T EKI + E G+ + +D + H+V P F+ + KV Sbjct: 1 MQKPQTIFEKIWE--NHMVHEEEGKPSLLYIDQHLVHEVTSPQA---FEGLRLNNRKVRR 55 Query: 212 REKVVIIPDHYIFTA------DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYK 373 + DH + T DE + + +D L+ C+E IK L+D +PD + Sbjct: 56 PDLTFATMDHNVPTVNRESFKDEISKKQMDALKKNCEEFGIK-------LADMY-HPD-Q 106 Query: 374 GVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPT 553 G+ H+ Q G +PG+ ++ DSHT GAFG A GIG ++ V+ T P T Sbjct: 107 GIVHVIGPQLGLTQPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTIWQDKPKT 166 Query: 554 IRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + + GE+ + AKDLIL II + V T ME+ G +I ++MEERMT+CNM Sbjct: 167 LNVKVIGELGIGVTAKDLILAIIAKFGVQFGTGYVMEYTGESIRKMSMEERMTICNM 223
>LEU2_BUCUH (Q9EVH7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Fragment) Length = 442 Score = 99.0 bits (245), Expect = 1e-20 Identities = 60/201 (29%), Positives = 103/201 (51%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D+ + H+V P + + KV EK DH + T N + + + Sbjct: 27 IDLHLIHEVTSPQAFDSLRNK---KRKVRQPEKTFATMDHNVSTQKRDINASGSMAKK-- 81 Query: 302 QEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFA 481 Q Q++ D ++S + N +G+ H+ ++G PG +++ DSHT GAFG + Sbjct: 82 QMQQLIRNCDEFNISLYDINNPNQGIVHVIAPEKGMTLPGMIIVCGDSHTSTHGAFGALS 141 Query: 482 TGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSM 661 GIG ++ V+ T + ++ + G++P ++ AKD+IL II + SG + + Sbjct: 142 FGIGTSEVEHVLATQTLKQQCFKNMKVEIVGDIPKFVTAKDIILFIIRRLGSSGGSGYVI 201 Query: 662 EFVGSTIESLTMEERMTLCNM 724 EF G+ IE ++MEERMT+CNM Sbjct: 202 EFCGNVIEKMSMEERMTVCNM 222
>LEU2_PSEAE (Q9HZA3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 474 Score = 99.0 bits (245), Expect = 1e-20 Identities = 53/178 (29%), Positives = 91/178 (51%), Gaps = 3/178 (1%) Frame = +2 Query: 200 KVWDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKD---LSDFRANPDY 370 K W + + PDH + T + + D +++ + D +++F+ N Sbjct: 51 KPWRIDANIATPDHNVPTTRTERKGGIAAIADEVSRLQVQTLDENCDDFGITEFKMNDVR 110 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T + K Sbjct: 111 QGIVHVVGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVAKKMK 170 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + ++G +P + AKD++L +IG I +G ++EF GS I L++E RMT+CNM Sbjct: 171 NMLVKVEGRLPAGVTAKDIVLAVIGRIGTAGGNGHAIEFAGSAIRDLSIEGRMTICNM 228
>LEU2_MYCPA (Q73VI7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 476 Score = 98.6 bits (244), Expect = 2e-20 Identities = 74/243 (30%), Positives = 114/243 (46%), Gaps = 9/243 (3%) Frame = +2 Query: 23 TGSVKSPMTTTEKILARASERASLEPGENV--WVDVDVLMTHDVCGPGTIGIFKQEFGED 196 TG+ +P T EK+ + + G N + +D+ + H+V P + Sbjct: 5 TGTTATPRTLAEKVW---DDHVVVSGGANEPDLIYIDLHLVHEVTSPQAFDGLRLA---G 58 Query: 197 AKVWDREKVVIIPDHYIFT-------ADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 V + + DH + T AD + V+ LR C E ++ Y + D Sbjct: 59 RPVRRPDLTLATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGVR-LYPMGDAE--- 114 Query: 356 ANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKAL 535 +G+ H+ Q G +PG ++ DSHT GAFG A GIG ++ V+ T Sbjct: 115 -----QGIVHVVGPQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLP 169 Query: 536 LKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTL 715 L+ T+ +DGE+P + AKD+IL +I +I G +E+ GS IESL+ME RMT+ Sbjct: 170 LRPFKTMAVNVDGELPAGVTAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTV 229 Query: 716 CNM 724 CNM Sbjct: 230 CNM 232
>LEU2_BUCUM (Q9EVG8) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Fragment) Length = 444 Score = 98.6 bits (244), Expect = 2e-20 Identities = 66/215 (30%), Positives = 110/215 (51%), Gaps = 7/215 (3%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------AD 259 GE++ + +D+ + H+V P + + KV +K DH + T + Sbjct: 22 GESI-LYIDLHLLHEVTSPQAFDALRSK---KRKVRQSKKTFATMDHNVSTKIQSISASG 77 Query: 260 ERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGT 439 A + ++ L C++ I YDI NP+ +G+ H+ ++G PG ++ Sbjct: 78 SMAKKQMEQLIKNCRDFNIP-LYDIN-------NPN-QGIVHVIAPEKGMTLPGMTIVCG 128 Query: 440 DSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQI 619 DSHT GAFG A GIG ++ V+ T K ++ + G++P ++ AKD+IL I Sbjct: 129 DSHTSTHGAFGALAFGIGTSEVEHVLATQTLKQKRFKNMKVEIIGKIPKFVTAKDIILFI 188 Query: 620 IGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 IG++ S T +EF G I++++MEERMT+CNM Sbjct: 189 IGQLGSSSGTGYVIEFCGDVIKNISMEERMTICNM 223
>LEU2_PHYBL (P18250) 3-isopropylmalate dehydratase (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 744 Score = 98.6 bits (244), Expect = 2e-20 Identities = 67/217 (30%), Positives = 106/217 (48%), Gaps = 10/217 (4%) Frame = +2 Query: 104 ENVWVD--VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRN 277 + VW D +D + H+V P F+ +V + + DH I T + ++ Sbjct: 7 DKVWDDHVIDRHLVHEVTSPQA---FEGLRNASRRVRRPDCTLATVDHNIPTTTRKKFKS 63 Query: 278 VDIL------RDFCQ--EQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLL 433 + R C+ E +K F +L+ F +G+ H+ ++G PG ++ Sbjct: 64 ITTFIDEADSRTQCETLETNVKEF----ELTYFGMEDSRQGIVHVIGPEQGFTLPGTTVV 119 Query: 434 GTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLIL 613 DSHT GAFG A GIG ++ V+ T L K +R ++GE+ P + +KD+ L Sbjct: 120 CGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLLQKKSKNMRVCVEGELTPGVTSKDVAL 179 Query: 614 QIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +IG I +G T +EF GS I SL+ME RM++CNM Sbjct: 180 HVIGLIGTAGGTRCVIEFCGSAIASLSMEARMSICNM 216
>LEU2_BUCUE (Q9EVH4) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Fragment) Length = 443 Score = 98.2 bits (243), Expect = 2e-20 Identities = 61/201 (30%), Positives = 102/201 (50%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D+ + H+V P + + V +K DH + T + N + + + Sbjct: 27 IDLHLIHEVTSPQAFDSLRHK---KRGVRQPQKTFATMDHNVSTQSKNINASGSMAQKQ- 82 Query: 302 QEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFA 481 EQ IK + ++S + N +G+ H+ ++G PG ++ DSHT GAFG + Sbjct: 83 MEQLIKNCNEF-NISLYDVNNPNQGIVHVIAPEKGMTLPGMTIVCGDSHTSTHGAFGALS 141 Query: 482 TGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSM 661 GIG ++ V+ T K ++ + G++P ++ AKD+IL IIG++ S T + Sbjct: 142 FGIGTSEVEHVLATQTLKQKRFKNMKITIIGKVPEFITAKDIILFIIGQLGSSRGTGYVI 201 Query: 662 EFVGSTIESLTMEERMTLCNM 724 EF G I +++MEERMTLCNM Sbjct: 202 EFFGDVINNMSMEERMTLCNM 222
>LEU2_AGRT5 (Q8UBY9) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 97.8 bits (242), Expect = 3e-20 Identities = 50/118 (42%), Positives = 70/118 (59%) Frame = +2 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ HI ++G PG ++ DSHT GAFG A GIG ++ V+ T + K Sbjct: 108 QGIVHIVGPEQGFTLPGMTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLIQKKAK 167 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + +DG++P + AKD+IL IIGEI +G T +EF G I SL+ME RMT+CNM Sbjct: 168 NMLVRVDGKLPESVTAKDIILAIIGEIGTAGGTGHVIEFAGEAIRSLSMEGRMTVCNM 225
>LEU2_THIDA (Q3SHL1) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 467 Score = 97.8 bits (242), Expect = 3e-20 Identities = 71/223 (31%), Positives = 108/223 (48%), Gaps = 12/223 (5%) Frame = +2 Query: 92 LEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDR-----EKVVIIPDHYIFT- 253 +EP + +D + H+V P Q F E K+ R + + +PDH + T Sbjct: 18 VEPDGTTLLYIDRHLVHEVTSP-------QAF-EGLKLAQRLPRRPDAAIAVPDHNVPTT 69 Query: 254 ------ADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCR 415 AD + V+ L C E I ++FR + +G+ H+ +EG Sbjct: 70 DRSQGIADPVSRLQVETLDANCAEFGI---------TEFRMDDVRQGIVHVIGPEEGLTL 120 Query: 416 PGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLL 595 PG ++ DSHT GAFG A GIG ++ V+ T K T+ ++GE+ + Sbjct: 121 PGMTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQCLWQKPSKTMLVKVEGELGKGVT 180 Query: 596 AKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 AKD+ L +IG I +G T ++EF G+ I +L+ME RMTLCNM Sbjct: 181 AKDIALAVIGRIGTAGGTGYAIEFGGAAIRALSMEGRMTLCNM 223
>LEU2_COREF (Q8FPR3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 481 Score = 97.4 bits (241), Expect = 4e-20 Identities = 75/250 (30%), Positives = 113/250 (45%), Gaps = 11/250 (4%) Frame = +2 Query: 8 TRPASTGSVKSPMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEF 187 T P S K +T EK+ R + E GE + +D+ + H+V P + Sbjct: 2 TSPVDASSSKEKLTLAEKVW-RDHVVSKGENGEPDLLYIDLQLLHEVTSPQAFDGLRMA- 59 Query: 188 GEDAKVWDREKVVIIPDHYIFTA-----------DERANRNVDILRDFCQEQKIKYFYDI 334 K+ + + DH + T D+ + V LRD C+E ++ + Sbjct: 60 --GRKLRRPDLHLATEDHNVPTEGIKTGSLLEINDQISRLQVSTLRDNCKEFGVR----L 113 Query: 335 KDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFV 514 + D R +G+ H Q G +PG ++ DSHT GAFG A GIG ++ V Sbjct: 114 HPMGDVR-----QGIVHTVGPQLGATQPGMTIVCGDSHTSTHGAFGAMAFGIGTSEVEHV 168 Query: 515 MGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLT 694 M T LK T+ + GE+ P + +KDLIL II +I G +E+ G I L+ Sbjct: 169 MATQTLPLKPFKTMAIEVTGELQPGVSSKDLILAIIAKIGTGGGQGYVLEYRGEAIRKLS 228 Query: 695 MEERMTLCNM 724 M+ RMT+CNM Sbjct: 229 MDARMTICNM 238
>LEU2_PYRAE (Q8ZW41) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 415 Score = 97.4 bits (241), Expect = 4e-20 Identities = 68/226 (30%), Positives = 111/226 (49%) Frame = +2 Query: 47 TTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVV 226 T TE IL + + PG+ V + D++ HD+ G + + + G+ +V+DRE+VV Sbjct: 3 TWTEYILYKKLGKTP-SPGDVVEIVPDLVGFHDLTGYHVLEVL-ESMGK-VEVFDRERVV 59 Query: 227 IIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEG 406 + DH ++RA + +R + + FYD+ G+ H + E Sbjct: 60 VAFDHLSPPPNQRAAEIMVYIRRHVKALGLPNFYDVGG-----------GILH-QIILEK 107 Query: 407 HCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPP 586 + PG+V+ DSHT AGA G FA G+G TD + GK + VP R + GE P Sbjct: 108 YALPGQVIFAADSHTNTAGAVGAFAHGMGATDIAAALKLGKTWIVVPAPFRIDVVGEFPI 167 Query: 587 YLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ KD+ L ++G+ G S+E T ++ M++R T+ NM Sbjct: 168 GVMGKDVALHLLGQFGAEGFNGYSVEVFVETPKAFPMDDRATVANM 213
>LEU2_PSEHT (Q3IJS4) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 97.4 bits (241), Expect = 4e-20 Identities = 61/203 (30%), Positives = 102/203 (50%), Gaps = 2/203 (0%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D + H+V P +++ + V EK DH + T +R++D + Sbjct: 27 IDRHLVHEVTSPQAFAGLREK---NRTVRCPEKTFATMDHNVSTK----SRSLDAASEVS 79 Query: 302 QEQKIKYFYDIKDLSD--FRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQ 475 + Q + + K+ + N +G+ H+ ++G PG ++ DSHT GAFG Sbjct: 80 KNQLMALDANCKEFGIVLYDLNSINQGIVHVMGPEQGITLPGTTIVCGDSHTSTHGAFGA 139 Query: 476 FATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYR 655 A GIG ++ V+ T K +++ ++G + P + AKDLI+ +IG++ +G T Sbjct: 140 LAHGIGTSEVEHVLATQTLQQKKAKSLKIQINGRLRPTVTAKDLIMAVIGKLGTAGGTGY 199 Query: 656 SMEFVGSTIESLTMEERMTLCNM 724 EF G IE+L+ME RMTLCNM Sbjct: 200 VAEFCGEGIEALSMEARMTLCNM 222
>LEU2_PHOPR (Q6LV26) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 476 Score = 97.1 bits (240), Expect = 5e-20 Identities = 74/243 (30%), Positives = 114/243 (46%), Gaps = 7/243 (2%) Frame = +2 Query: 17 ASTGSVKSPMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGED 196 A TG+ K T EK+ + A GEN + +D + H+V P +++ Sbjct: 3 AKTGTSK---TLYEKVYD--AHVAVAAEGENPILYIDRHLVHEVTSPQAFDGLREK---G 54 Query: 197 AKVWDREKVVIIPDHYIFT-------ADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 KV K DH + T + E A ++ L C+E + YD+ Sbjct: 55 RKVRQIGKTFATMDHNVSTQTKDINASGEMARIQMETLAKNCKEFGVT-LYDL------- 106 Query: 356 ANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKAL 535 N Y+G+ H+ + G PG ++ DSHT GAFG A GIG ++ V+ T Sbjct: 107 -NHKYQGIVHVIGPELGITLPGMTIVCGDSHTATHGAFGSLAFGIGTSEVEHVLATQTLK 165 Query: 536 LKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTL 715 + T++ + G++ + AKD++L IIG+ + +G T +EF G I LTME RMT+ Sbjct: 166 QSLAKTMKIEVVGKVAEGITAKDIVLAIIGKTTAAGGTGYVVEFCGEAITDLTMEGRMTV 225 Query: 716 CNM 724 CNM Sbjct: 226 CNM 228
>LEU2_BUCPS (P58945) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 465 Score = 97.1 bits (240), Expect = 5e-20 Identities = 62/201 (30%), Positives = 101/201 (50%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D+ + H+V P + + + K+ +K DH + T + R +N + + Sbjct: 27 IDLHLIHEVTXPQAFNSLRLK---NRKIRQPKKTFATMDHNVPTHN-RDIKNSEYMAKIQ 82 Query: 302 QEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFA 481 E+ K D ++ + N ++G+ H+ ++G PG V++ DSHT GAFG A Sbjct: 83 MEELSKNCKDF-NIKLYDINHPHQGIVHVLGPEKGMTLPGMVIVCGDSHTSTHGAFGALA 141 Query: 482 TGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSM 661 GIG ++ V+ T T+ + G + P + AKD+IL II ++S SG + Sbjct: 142 FGIGTSEVEHVLATQTLQQNRLKTMNIEITGNINPMVFAKDIILSIIRKLSTSGGIGYVI 201 Query: 662 EFVGSTIESLTMEERMTLCNM 724 EF GS I L+ME RMT+CNM Sbjct: 202 EFSGSVISQLSMESRMTICNM 222
>LEU2_VIBCH (Q9KP81) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 467 Score = 97.1 bits (240), Expect = 5e-20 Identities = 62/209 (29%), Positives = 103/209 (49%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRN 277 PGE + +D + H+V P +++ +V K DH + T + N + Sbjct: 21 PGETPILYIDRHLVHEVTSPQAFDGLREKGRPVRQV---SKTFATMDHNVSTTTKDINAS 77 Query: 278 VDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCN 457 ++ R Q Q + + ++ + N Y+G+ H+ + G PG ++ DSHT Sbjct: 78 GEMAR--IQMQTLSKNCEEFGVTLYDINHKYQGIVHVMGPELGITLPGMTIVCGDSHTAT 135 Query: 458 AGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISV 637 GAFG A GIG ++ V+ T T++ + G++ P + AKD++L IIG+ + Sbjct: 136 HGAFGSLAFGIGTSEVEHVLATQTLKQGRAKTMKIEVRGKVAPGITAKDIVLAIIGKTTA 195 Query: 638 SGATYRSMEFVGSTIESLTMEERMTLCNM 724 +G T +EF G I L+ME RMT+CNM Sbjct: 196 AGGTGYVVEFCGEAIRDLSMEGRMTVCNM 224
>LEU2_YERPS (Q66EM3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 476 Score = 96.7 bits (239), Expect = 7e-20 Identities = 66/214 (30%), Positives = 102/214 (47%), Gaps = 5/214 (2%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRN 277 P E + +D + H+V P + V K DH + T + N + Sbjct: 25 PNETPLLYIDRHLVHEVTSPQAFDGLR---AMGRPVRQPGKTFATMDHNVSTQTKDINAS 81 Query: 278 VDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQEGHCRPGEVLLGTD 442 ++ R QE IK+ ++F N ++G+ H+ ++G PG ++ D Sbjct: 82 GEMARIQMQEL-------IKNCAEFGVSLYDLNHPFQGIVHVIGPEQGMTLPGMTIVCGD 134 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V+ T T+R ++G + + AKD++L II Sbjct: 135 SHTATHGAFGSLAFGIGTSEVEHVLATQTLKQGRAKTMRIEVNGTVGAGITAKDIVLAII 194 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G+ +G T +EF GS IE+L+ME RMTLCNM Sbjct: 195 GKTGSAGGTGHVVEFCGSAIEALSMEGRMTLCNM 228
>LEU2_YERPE (Q8ZIH0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 476 Score = 96.7 bits (239), Expect = 7e-20 Identities = 66/214 (30%), Positives = 102/214 (47%), Gaps = 5/214 (2%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRN 277 P E + +D + H+V P + V K DH + T + N + Sbjct: 25 PNETPLLYIDRHLVHEVTSPQAFDGLR---AMGRPVRQPGKTFATMDHNVSTQTKDINAS 81 Query: 278 VDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQEGHCRPGEVLLGTD 442 ++ R QE IK+ ++F N ++G+ H+ ++G PG ++ D Sbjct: 82 GEMARIQMQEL-------IKNCAEFGVSLYDLNHPFQGIVHVIGPEQGMTLPGMTIVCGD 134 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V+ T T+R ++G + + AKD++L II Sbjct: 135 SHTATHGAFGSLAFGIGTSEVEHVLATQTLKQGRAKTMRIEVNGTVGAGITAKDIVLAII 194 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G+ +G T +EF GS IE+L+ME RMTLCNM Sbjct: 195 GKTGSAGGTGHVVEFCGSAIEALSMEGRMTLCNM 228
>LEU2_MYCLE (O33123) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 476 Score = 96.7 bits (239), Expect = 7e-20 Identities = 73/246 (29%), Positives = 116/246 (47%), Gaps = 13/246 (5%) Frame = +2 Query: 26 GSVKSPMTTTEKI----LARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGE 193 G + P T EK+ + A + + G ++ + +D+ + H+V P + Sbjct: 2 GGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDL-IYIDLHLVHEVTSPQAFDGLRL---- 56 Query: 194 DAKVWDR--EKVVIIPDHYIFT-------ADERANRNVDILRDFCQEQKIKYFYDIKDLS 346 A W R + V DH + T AD + V+ LR C E ++ + + Sbjct: 57 -AGRWVRRPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVR----LHPMG 111 Query: 347 DFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTG 526 D +G+ H+ Q G +PG ++ DSHT GAFG A GIG ++ V+ T Sbjct: 112 DIE-----QGIVHVVGPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQ 166 Query: 527 KALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEER 706 L+ T+ +DG +P + AKD+IL +I +I G +E+ GS IES++ME R Sbjct: 167 TLPLRPFKTMAVTVDGRLPAGVTAKDIILALIAKIGTGGGQGYVLEYRGSVIESMSMEGR 226 Query: 707 MTLCNM 724 MT+CNM Sbjct: 227 MTICNM 232
>LEU2_BLOPB (Q493R2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 96.7 bits (239), Expect = 7e-20 Identities = 60/176 (34%), Positives = 92/176 (52%), Gaps = 5/176 (2%) Frame = +2 Query: 212 REKVVIIPDHYIFTADERA---NRNVDILRDFCQEQKIKYFYDIKD--LSDFRANPDYKG 376 R+++V P+ T D +N++ +EQ + + KD ++ F N Y+G Sbjct: 47 RKRIVRQPNKTFATMDHNVPTTTKNINHSGSMAKEQLDRLTKNCKDFGITLFGLNHPYQG 106 Query: 377 VCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTI 556 + H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T ++ Sbjct: 107 IVHVLAPEQGITLPGMTIVCGDSHTATHGAFGALAFGIGTSEIEHVLATQTLQQIRYKSM 166 Query: 557 RFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + L G + P + AKD+IL IIG+I G + +EF G I L+MEERMTLCNM Sbjct: 167 QINLSGIIAPQITAKDIILAIIGKIGHGGGSGHVVEFCGPIITLLSMEERMTLCNM 222
>LEU2_PROMP (Q7V336) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 96.3 bits (238), Expect = 9e-20 Identities = 63/216 (29%), Positives = 98/216 (45%), Gaps = 7/216 (3%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------A 256 PG + + + + + H+V P G K + + KV ++ V DH + T Sbjct: 20 PGGSDQILIGLHLIHEVTSPQAFGALKDK---NLKVKFPQRTVATVDHIVPTDNQSRPFK 76 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 D A + +D L C E KIK+F +G+ H+ + G +PG + Sbjct: 77 DNLAEQMIDTLEKNCIEHKIKFF---------NIGSGNQGIVHVVAPELGLTQPGMTIAC 127 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG + V+ + + + + ++ + AKDL+L Sbjct: 128 GDSHTSTHGAFGSIAFGIGTSQVRDVLASQTIAMNKLKVRQIWCENKLSNGIYAKDLVLH 187 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 II ++ V + EF G I L+MEERMT+CNM Sbjct: 188 IINQLGVKAGVGYAYEFAGPAISELSMEERMTICNM 223
>LEU2_ASHGO (Q74ZM9) 3-isopropylmalate dehydratase (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 776 Score = 96.3 bits (238), Expect = 9e-20 Identities = 62/172 (36%), Positives = 88/172 (51%), Gaps = 9/172 (5%) Frame = +2 Query: 236 DHYIFTADERANRNVDI--------LRDFCQEQKIKYFY-DIKDLSDFRANPDYKGVCHI 388 DH I T R RN + L+ EQ +K F+ +SD R +G+ HI Sbjct: 66 DHNIPTESRRHFRNTESFIKEADSRLQVQTLEQNVKDFHVPYLGMSDER-----QGIVHI 120 Query: 389 ALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVL 568 ++G PG ++ DSHT GAFG A GIG ++ V+ T + +R + Sbjct: 121 IGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTVMQSKSKNMRIHV 180 Query: 569 DGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +G + P + +KDLIL IIG I +G T +EF G I+ LTME RM++CNM Sbjct: 181 EGSLSPGITSKDLILHIIGVIGTAGGTGCVIEFTGQAIQELTMEARMSMCNM 232
>LEU2_BUCTS (O31293) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 96.3 bits (238), Expect = 9e-20 Identities = 62/207 (29%), Positives = 101/207 (48%), Gaps = 5/207 (2%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D+ + H+V P K +++++V P T D + + + Sbjct: 27 IDLHLLHEVTSPQAFESLK----------NKKRIVHAPIKTFATMDHNVSTKTNKISASG 76 Query: 302 QEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGA 466 + +I+ I + DF N +G+ H+ ++G PG ++ DSHT GA Sbjct: 77 KAAQIQMQQLINNCKDFNIKLYDLNHINQGIVHVMGPEQGLTLPGMTIVCGDSHTSTHGA 136 Query: 467 FGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGA 646 FG A GIG ++ V+ T T++ ++G + PY+ AKD+IL II ++ + Sbjct: 137 FGTLAFGIGTSEVEHVLATQTLKQARSKTMKIGINGILKPYITAKDVILYIIKKVGTAFG 196 Query: 647 TYRSMEFVGSTIESLTMEERMTLCNMV 727 T +EF G TIE+LTME RMT+CNMV Sbjct: 197 TGYVVEFSGETIENLTMEGRMTICNMV 223
>LEU2_NOCFA (Q5YRY0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 474 Score = 96.3 bits (238), Expect = 9e-20 Identities = 69/231 (29%), Positives = 111/231 (48%), Gaps = 8/231 (3%) Frame = +2 Query: 56 EKILARAS-ERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVII 232 E ++AR E AS EP + +D+ + H+V P + V + + Sbjct: 15 EHVVARGEGEGASREPD---LIYIDLHLVHEVTSPQAFDGLR---AAGRPVRRPDLTIAT 68 Query: 233 PDHYIFT-------ADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIA 391 DH + T AD + V+ LR C E I+ + + DL +G+ H+ Sbjct: 69 EDHNVPTVDIDKPIADPISRTQVETLRRNCAEFGIR-LHPMGDLE--------QGIVHVV 119 Query: 392 LAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLD 571 Q G +PG ++ DSHT GAFG A GIG ++ V+ T L+ T+ +D Sbjct: 120 GPQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLSLRPFKTMAINID 179 Query: 572 GEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G++PP + +KD+IL +I +I G +E+ G + +++ME RMT+CNM Sbjct: 180 GQLPPGVTSKDVILAVIAQIGTGGGQGYVLEYRGEAVRAMSMEARMTMCNM 230
>LEU2_SALTI (Q8Z9I2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 465 Score = 95.9 bits (237), Expect = 1e-19 Identities = 65/214 (30%), Positives = 99/214 (46%), Gaps = 5/214 (2%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRN 277 P E + +D + H+V P + V K DH + T + N + Sbjct: 18 PNETPLLYIDRHLVHEVTSPQAFDGLR---AHHRPVRQPGKTFATMDHNVSTQTKDINAS 74 Query: 278 VDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQEGHCRPGEVLLGTD 442 ++ R QE IK+ ++F N Y+G+ H+ ++G PG ++ D Sbjct: 75 GEMARIQMQEL-------IKNCNEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V+ T T++ + G P + AKD++L II Sbjct: 128 SHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVTGNAAPGITAKDIVLAII 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G+ +G T +EF G I +L+ME RMTLCNM Sbjct: 188 GKTGSAGGTGHVVEFCGDAIRALSMEGRMTLCNM 221
>LEU21_SALTY (P15717) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 465 Score = 95.9 bits (237), Expect = 1e-19 Identities = 65/214 (30%), Positives = 99/214 (46%), Gaps = 5/214 (2%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRN 277 P E + +D + H+V P + V K DH + T + N + Sbjct: 18 PNETPLLYIDRHLVHEVTSPQAFDGLR---AHHRPVRQPGKTFATMDHNVSTQTKDINAS 74 Query: 278 VDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQEGHCRPGEVLLGTD 442 ++ R QE IK+ ++F N Y+G+ H+ ++G PG ++ D Sbjct: 75 GEMARIQMQEL-------IKNCNEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V+ T T++ + G P + AKD++L II Sbjct: 128 SHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVTGNAAPGITAKDIVLAII 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G+ +G T +EF G I +L+ME RMTLCNM Sbjct: 188 GKTGSAGGTGHVVEFCGDAIRALSMEGRMTLCNM 221
>LEU2_RHIPU (P55251) 3-isopropylmalate dehydratase (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 755 Score = 95.9 bits (237), Expect = 1e-19 Identities = 66/209 (31%), Positives = 101/209 (48%), Gaps = 8/209 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDIL---- 289 +D + H+V P F+ KV + + DH I T + +NV Sbjct: 27 IDRHLVHEVTSPQA---FEGLRNAGRKVRRPDCTLATVDHNIPTTPRKNFKNVSTFIQEA 83 Query: 290 --RDFCQ--EQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCN 457 R C+ E +K F L+ F + +G+ H+ ++G PG + DSHT Sbjct: 84 DSRTQCETLEHNVKEF----GLTYFGMDDSRQGIVHVIGPEQGFTLPGCTVNCGDSHTST 139 Query: 458 AGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISV 637 GAFG A GIG ++ V+ T L K +R +DG++ P + +KD++L IIG I Sbjct: 140 HGAFGALAFGIGTSEVEHVLATQTLLQKKSKNMRVKVDGKLAPGVTSKDIVLHIIGVIGT 199 Query: 638 SGATYRSMEFVGSTIESLTMEERMTLCNM 724 +G T +EF GS E ++ME RM++CNM Sbjct: 200 AGGTGCVIEFCGSAFEQMSMEARMSVCNM 228
>LEU2_VIBPA (Q87SS9) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 471 Score = 95.9 bits (237), Expect = 1e-19 Identities = 61/208 (29%), Positives = 102/208 (49%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNV 280 GE + +D + H+V P +++ KV K DH + T + N + Sbjct: 20 GETPILYIDRHLVHEVTSPQAFDGLREK---GRKVRQVSKTFATMDHNVSTTTKDINASG 76 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 ++ R Q + + + ++ + N Y+G+ H+ + G PG ++ DSHT Sbjct: 77 EMAR--IQMETLSKNCEEFGVTLYDLNHKYQGIVHVMGPELGITLPGMTIVCGDSHTATH 134 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T T++ + G++ P + AKD++L IIG+ + + Sbjct: 135 GAFGSLAFGIGTSEVEHVLATQTLKQARAKTMKIEVKGKVAPGITAKDIVLAIIGKTTAA 194 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 G T +EF G I L+ME RMT+CNM Sbjct: 195 GGTGYVVEFCGEAITDLSMEGRMTVCNM 222
>LEU2_SALPA (Q5PDG3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 95.9 bits (237), Expect = 1e-19 Identities = 65/214 (30%), Positives = 99/214 (46%), Gaps = 5/214 (2%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRN 277 P E + +D + H+V P + V K DH + T + N + Sbjct: 19 PNETPLLYIDRHLVHEVTSPQAFDGLR---AHHRPVRQPGKTFATMDHNVSTQTKDINAS 75 Query: 278 VDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQEGHCRPGEVLLGTD 442 ++ R QE IK+ ++F N Y+G+ H+ ++G PG ++ D Sbjct: 76 GEMARIQMQEL-------IKNCNEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGD 128 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V+ T T++ + G P + AKD++L II Sbjct: 129 SHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVTGSAAPGITAKDIVLAII 188 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G+ +G T +EF G I +L+ME RMTLCNM Sbjct: 189 GKTGSAGGTGHVVEFCGDAIRALSMEGRMTLCNM 222
>LEU21_SALCH (Q57TE8) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 466 Score = 95.9 bits (237), Expect = 1e-19 Identities = 65/214 (30%), Positives = 99/214 (46%), Gaps = 5/214 (2%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRN 277 P E + +D + H+V P + V K DH + T + N + Sbjct: 19 PNETPLLYIDRHLVHEVTSPQAFDGLR---AHHRPVRQPGKTFATMDHNVSTQTKDINAS 75 Query: 278 VDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQEGHCRPGEVLLGTD 442 ++ R QE IK+ ++F N Y+G+ H+ ++G PG ++ D Sbjct: 76 GEMARIQMQEL-------IKNCNEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGD 128 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V+ T T++ + G P + AKD++L II Sbjct: 129 SHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVTGNAAPGITAKDIVLAII 188 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G+ +G T +EF G I +L+ME RMTLCNM Sbjct: 189 GKTGSAGGTGHVVEFCGDAIRALSMEGRMTLCNM 222
>LEU2_LISIN (Q92A26) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 462 Score = 95.9 bits (237), Expect = 1e-19 Identities = 63/214 (29%), Positives = 109/214 (50%), Gaps = 6/214 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER----- 265 GE + VD+ + H+V P + E + + +K DH + T D Sbjct: 20 GEPQLLYVDLHLIHEVTSPQAFEGLRME---NRPLRRPDKTFATMDHNVPTEDIFNIQDL 76 Query: 266 -ANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTD 442 A + ++ L+ C+E + L+D + D +G+ H+ + G +PG+V++ D Sbjct: 77 VAKKQIEALQTNCEEFGVT-------LADMGS--DRQGIVHMVGPETGLTQPGKVIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG GIG+++ V T + P ++ ++G++P + AKD+IL +I Sbjct: 128 SHTATHGAFGAIGFGIGSSEVEHVFATQTIWQQKPKSMGIEINGKLPKGVYAKDIILHLI 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 V+ T ++E+ G TI +++MEERMT+CNM Sbjct: 188 ATYGVAFGTGYAVEYYGETIRNMSMEERMTICNM 221
>LEU2_LISMF (Q71Y33) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 462 Score = 95.5 bits (236), Expect = 1e-19 Identities = 63/214 (29%), Positives = 108/214 (50%), Gaps = 6/214 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER----- 265 GE + VD+ + H+V P + E + + +K DH + T D Sbjct: 20 GEPQLLYVDLHLIHEVTSPQAFEGLRME---NRPLRRPDKTFATMDHNVPTEDIFNIQDL 76 Query: 266 -ANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTD 442 A + ++ L+ C+E + L+D + D +G+ H+ + G +PG+V++ D Sbjct: 77 VAKKQIEALQTNCEEFGVT-------LADMGS--DRQGIVHMVGPETGLTQPGKVIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG GIG+++ V T + P ++ ++G +P + AKD+IL +I Sbjct: 128 SHTATHGAFGAIGFGIGSSEVEHVFATQTIWQQKPKSMGIEINGNLPKGVYAKDIILHLI 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 V+ T ++E+ G TI +++MEERMT+CNM Sbjct: 188 ATYGVAFGTGYAVEYYGETIRNMSMEERMTICNM 221
>LEU2_NEIG1 (Q5F8T1) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 95.5 bits (236), Expect = 1e-19 Identities = 67/203 (33%), Positives = 97/203 (47%), Gaps = 2/203 (0%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD--ERANRNVDILRD 295 +D + H+V P K K+W + VV DH T D + + L+ Sbjct: 28 IDRHLVHEVTSPQAFEGLKMA---GRKLWRIDSVVSTADHNTPTGDWDKGIQDPISKLQV 84 Query: 296 FCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQ 475 +Q IK F L+ F +G+ H+ ++G PG ++ DSHT GAFG Sbjct: 85 DTLDQNIKEF---GALAYFPFMDKGQGIVHVMGPEQGATLPGMTVVCGDSHTSTHGAFGA 141 Query: 476 FATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYR 655 A GIG ++ M T K ++ DG++ + AKD+ L IIG+I +G T Sbjct: 142 LAHGIGTSEVEHTMATQCITAKKSKSMLIAADGKLKAGVTAKDVALYIIGQIGTAGGTGY 201 Query: 656 SMEFVGSTIESLTMEERMTLCNM 724 ++EF G I SL+ME RMTLCNM Sbjct: 202 AVEFGGEAIRSLSMEGRMTLCNM 224
>LEU2_STRCO (O86534) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 476 Score = 95.5 bits (236), Expect = 1e-19 Identities = 69/215 (32%), Positives = 100/215 (46%), Gaps = 7/215 (3%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------AD 259 GE + +D+ + H+V P ++ G + D + DH T AD Sbjct: 20 GEPDLLFIDLHLLHEVTSPQAFDGLRKS-GRPVRRLDL--TIATEDHNTPTLDIDKPIAD 76 Query: 260 ERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGT 439 + ++ LR C + ++ + L D +GV H+ Q G +PG ++ Sbjct: 77 PVSRAQLETLRKNCADFGVR----LHPLGDVE-----QGVVHVVGPQLGLTQPGTTVVCG 127 Query: 440 DSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQI 619 DSHT GAFG A GIG + V+ T L P T+ +DGE+P + AKDLIL I Sbjct: 128 DSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPKTMAITVDGELPEGVTAKDLILAI 187 Query: 620 IGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 I I G +E+ G IE L+ME RMT+CNM Sbjct: 188 IARIGTGGGQGYILEYRGEAIEKLSMEARMTICNM 222
>LEU2_VIBF1 (Q5E858) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 471 Score = 95.5 bits (236), Expect = 1e-19 Identities = 66/215 (30%), Positives = 102/215 (47%), Gaps = 7/215 (3%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------AD 259 GEN + +D + H+V P +++ KV K DH + T + Sbjct: 22 GENPILYIDRHLVHEVTSPQAFDGLREK---GRKVRQVGKTFATMDHNVSTQTKDINASG 78 Query: 260 ERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGT 439 E A ++ L C+E + YD+ N Y+G+ H+ + G PG ++ Sbjct: 79 EMARIQMETLSKNCEEFGVT-LYDL--------NHKYQGIVHVMGPELGITLPGMTIVCG 129 Query: 440 DSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQI 619 DSHT GAFG A GIG ++ V+ T T++ + G++ + AKD++L I Sbjct: 130 DSHTATHGAFGSLAFGIGTSEVEHVLATQTLKQARAKTMKIDVKGKVAEGITAKDIVLAI 189 Query: 620 IGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 IG+ + +G T +EF G I LTME RMT+CNM Sbjct: 190 IGKTTAAGGTGYVVEFCGEAITDLTMEGRMTVCNM 224
>LEU2_BACTN (Q8A6L7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 464 Score = 95.5 bits (236), Expect = 1e-19 Identities = 65/203 (32%), Positives = 99/203 (48%), Gaps = 2/203 (0%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D L H+V P ++ KV EKV +PDH T D+ + I Sbjct: 26 IDRLYCHEVTSPQAFAGLRER---GIKVLRPEKVFCMPDHNTPTHDQ----DKPIEDPIS 78 Query: 302 QEQKIKYFYDIKD--LSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQ 475 + Q + KD L+ F G+ H+ + PG ++ DSHT GA G Sbjct: 79 KTQVDTLTKNAKDFGLTHFGMMHPKNGIIHVVGPERALTLPGMTIVCGDSHTSTHGAMGA 138 Query: 476 FATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYR 655 A GIG ++ V+ + L P T+R +DGE+ + AKD+ L ++ +++ SGAT Sbjct: 139 IAFGIGTSEVEMVLASQCILQSRPKTMRITVDGELGKGVTAKDVALYMMSKMTTSGATGY 198 Query: 656 SMEFVGSTIESLTMEERMTLCNM 724 +E+ GS I +LTME R+TLCN+ Sbjct: 199 FVEYAGSAIRNLTMEGRLTLCNL 221
>LEU2_BACCZ (Q63DX6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 464 Score = 95.5 bits (236), Expect = 1e-19 Identities = 64/207 (30%), Positives = 104/207 (50%), Gaps = 6/207 (2%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT------ADERANRNVD 283 +D+ + H+V P F+ + KV + DH I T D A + +D Sbjct: 27 IDLHLVHEVTSPQA---FEGLRLTNRKVRRPDLTFATMDHNIPTKDVWNITDRIAKQQLD 83 Query: 284 ILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAG 463 LR+ C++ ++ + D+ D + +G+ H+ + G +PG+ ++ DSHT G Sbjct: 84 TLRENCKQFQVP----LADIGD-----EEQGIVHVIGPELGLTQPGKTIVCGDSHTATHG 134 Query: 464 AFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSG 643 AFG A GIG ++ V+ T + P + L G++ + AKD+IL ++ + V+ Sbjct: 135 AFGALAFGIGTSEVEHVLATQTLWQRKPKAMGIELKGKLQKGVYAKDIILHLLSKYGVAV 194 Query: 644 ATYRSMEFVGSTIESLTMEERMTLCNM 724 T MEF G TI ++ MEERMTLCNM Sbjct: 195 GTGYVMEFYGETIGAMEMEERMTLCNM 221
>LEU2_BACC1 (Q73B98) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 464 Score = 95.5 bits (236), Expect = 1e-19 Identities = 53/156 (33%), Positives = 87/156 (55%) Frame = +2 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 D A + +D LR+ C++ ++ + D+ D + +G+ H+ + G +PG+ ++ Sbjct: 75 DRIAKQQLDTLRENCKQFQVP----LADIGD-----EEQGIVHVIGPELGLTQPGKTIVC 125 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG ++ V+ T + P + L G++ + AKD+IL Sbjct: 126 GDSHTATHGAFGALAFGIGTSEVEHVLATQTLWQRKPKAMGIELKGKLQKGVYAKDIILH 185 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ + V+ T MEF G TI+++ MEERMTLCNM Sbjct: 186 LLSKYGVAVGTGYVMEFYGETIQAMEMEERMTLCNM 221
>LEU2_ERWCT (Q6D0G6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 95.5 bits (236), Expect = 1e-19 Identities = 65/214 (30%), Positives = 100/214 (46%), Gaps = 5/214 (2%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRN 277 P E + +D + H+V P + KV K DH + T + N + Sbjct: 19 PNETPLLYIDRHLVHEVTSPQAFDGLR---AMGRKVRQPGKTFATMDHNVSTQTKDINAS 75 Query: 278 VDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQEGHCRPGEVLLGTD 442 ++ R QE IK+ ++F N Y+G+ H+ ++G PG ++ D Sbjct: 76 GEMARIQMQEL-------IKNCAEFGVQLYDLNHPYQGIVHVIGPEQGMTLPGMTIVCGD 128 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V+ T T++ + G+ + AKD++L II Sbjct: 129 SHTATHGAFGSLAFGIGTSEVEHVLATQTLKQGRAKTMKIEVTGDAAHGITAKDIVLAII 188 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G+ +G T +EF G I +L+ME RMTLCNM Sbjct: 189 GKTGSAGGTGHVVEFCGKAIRALSMEGRMTLCNM 222
>LEU2_XYLFT (Q87BP9) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 474 Score = 95.5 bits (236), Expect = 1e-19 Identities = 63/223 (28%), Positives = 113/223 (50%), Gaps = 3/223 (1%) Frame = +2 Query: 65 LARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHY 244 +AR + +SL +++D +L H+V P F+ +W + PDH Sbjct: 16 VARRDDGSSL-----IYIDRHIL--HEVTSPQA---FEGLRLAGRPLWRVNANIATPDHN 65 Query: 245 IFTADERANRNVDILRDFCQEQKIKYFYDIKD---LSDFRANPDYKGVCHIALAQEGHCR 415 + T ++ + D +++ + D + +F+ N +G+ H+ ++G Sbjct: 66 VPTTKAERQGSLLSIADTVSRLQVQTLDENCDDFGIFEFKMNDVRQGIVHVIGPEQGATL 125 Query: 416 PGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLL 595 PG ++ DSHT GAFG A GIG ++ V+ T + + ++ ++G +P + Sbjct: 126 PGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVTQKMKNMQVRVEGTLPWGVT 185 Query: 596 AKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 AKD++L +IG+I +G ++EF GSTI +L+ME RMT+CNM Sbjct: 186 AKDIVLALIGKIGTAGGNGYAVEFSGSTIRALSMEGRMTICNM 228
>LEU2_XYLFA (Q9PAX0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 474 Score = 95.5 bits (236), Expect = 1e-19 Identities = 63/223 (28%), Positives = 113/223 (50%), Gaps = 3/223 (1%) Frame = +2 Query: 65 LARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHY 244 +AR + +SL +++D +L H+V P F+ +W + PDH Sbjct: 16 VARRDDGSSL-----IYIDRHIL--HEVTSPQA---FEGLRLAGRPLWRVNANIATPDHN 65 Query: 245 IFTADERANRNVDILRDFCQEQKIKYFYDIKD---LSDFRANPDYKGVCHIALAQEGHCR 415 + T ++ + D +++ + D + +F+ N +G+ H+ ++G Sbjct: 66 VPTTKAERQGSLLSIADTVSRLQVQTLDENCDDFGIFEFKMNDVRQGIVHVIGPEQGATL 125 Query: 416 PGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLL 595 PG ++ DSHT GAFG A GIG ++ V+ T + + ++ ++G +P + Sbjct: 126 PGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVTQKMKNMQVRVEGTLPWGVT 185 Query: 596 AKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 AKD++L +IG+I +G ++EF GSTI +L+ME RMT+CNM Sbjct: 186 AKDIVLALIGKIGTAGGNGYAVEFSGSTIRALSMEGRMTICNM 228
>LEU2_NEIMB (Q9JZI5) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 95.1 bits (235), Expect = 2e-19 Identities = 68/212 (32%), Positives = 101/212 (47%), Gaps = 2/212 (0%) Frame = +2 Query: 95 EPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD--ERA 268 E V + +D + H+V P K K+W + VV DH T D + Sbjct: 19 EEDGTVLLYIDRHLVHEVTSPQAFEGLKMA---GRKLWRIDSVVSTADHNTPTGDWDKGI 75 Query: 269 NRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSH 448 + L+ ++ IK F L+ F +G+ H+ ++G PG ++ DSH Sbjct: 76 QDPISKLQVDTLDKNIKEF---GALAYFPFMDKGQGIVHVMGPEQGATLPGMTVVCGDSH 132 Query: 449 TCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGE 628 T GAFG A GIG ++ M T K ++ +DG++ + AKD+ L IIG+ Sbjct: 133 TSTHGAFGALAHGIGTSEVEHTMATQCITAKKSKSMLISVDGKLKAGVTAKDVALYIIGQ 192 Query: 629 ISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 I +G T ++EF G I SL+ME RMTLCNM Sbjct: 193 IGTAGGTGYAIEFGGEAIRSLSMESRMTLCNM 224
>LEU2_NEIMA (Q9JU82) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 95.1 bits (235), Expect = 2e-19 Identities = 68/212 (32%), Positives = 101/212 (47%), Gaps = 2/212 (0%) Frame = +2 Query: 95 EPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD--ERA 268 E V + +D + H+V P K K+W + VV DH T D + Sbjct: 19 EEDGTVLLYIDRHLVHEVTSPQAFEGLKMA---GRKLWRIDSVVSTADHNTPTGDWDKGI 75 Query: 269 NRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSH 448 + L+ ++ IK F L+ F +G+ H+ ++G PG ++ DSH Sbjct: 76 QDPISKLQVDTLDKNIKEF---GALAYFPFMDKGQGIVHVMGPEQGATLPGMTVVCGDSH 132 Query: 449 TCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGE 628 T GAFG A GIG ++ M T K ++ +DG++ + AKD+ L IIG+ Sbjct: 133 TSTHGAFGALAHGIGTSEVEHTMATQCITAKKSKSMLIAVDGKLKAGVTAKDVALYIIGQ 192 Query: 629 ISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 I +G T ++EF G I SL+ME RMTLCNM Sbjct: 193 IGTAGGTGYAIEFGGEAIRSLSMEGRMTLCNM 224
>LEU2_CORGL (P58946) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 481 Score = 95.1 bits (235), Expect = 2e-19 Identities = 73/250 (29%), Positives = 112/250 (44%), Gaps = 11/250 (4%) Frame = +2 Query: 8 TRPASTGSVKSPMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEF 187 T P + +T EK+ R + E GE + +D+ + H+V P + Sbjct: 2 TSPVENSTSTEKLTLAEKVW-RDHVVSKGENGEPDLLYIDLQLLHEVTSPQAFDGLRMT- 59 Query: 188 GEDAKVWDREKVVIIPDHYIFTA-----------DERANRNVDILRDFCQEQKIKYFYDI 334 K+ E + DH + T D+ + V LRD C+E ++ + Sbjct: 60 --GRKLRHPELHLATEDHNVPTEGIKTGSLLEINDKISRLQVSTLRDNCEEFGVR----L 113 Query: 335 KDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFV 514 + D R +G+ H Q G +PG ++ DSHT GAFG A GIG ++ V Sbjct: 114 HPMGDVR-----QGIVHTVGPQLGATQPGMTIVCGDSHTSTHGAFGSMAFGIGTSEVEHV 168 Query: 515 MGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLT 694 M T LK T+ + GE+ P + +KDLIL II +I G +E+ G I ++ Sbjct: 169 MATQTLPLKPFKTMAIEVTGELQPGVSSKDLILAIIAKIGTGGGQGYVLEYRGEAIRKMS 228 Query: 695 MEERMTLCNM 724 M+ RMT+CNM Sbjct: 229 MDARMTMCNM 238
>LEU22_SALTY (Q8ZRJ0) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 473 Score = 95.1 bits (235), Expect = 2e-19 Identities = 57/179 (31%), Positives = 96/179 (53%), Gaps = 7/179 (3%) Frame = +2 Query: 209 DREKVVIIPDHYIFTADE----RANRNVDILRDFCQEQKIKYFYDIK---DLSDFRANPD 367 +R + V PD ++ D R+ R+ D++ D + ++ YF + ++ F Sbjct: 48 ERGRTVRHPDTFLLNIDHVNPTRSQRD-DLMTDPGGQLQVDYFRENAADFGITLFDVLDP 106 Query: 368 YKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVP 547 +G+ H+ ++G PG V+ DSHT GAFG GIG ++ ++ T + + Sbjct: 107 RQGIEHVVAHEQGLVMPGMVIAAGDSHTTTYGAFGALGFGIGTSEIEHLLATQTLVYRKL 166 Query: 548 PTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 T+R + GE+P AKD++L+++ I GAT ++EFVG I +L++E RMTLCNM Sbjct: 167 KTMRVSVQGELPFACSAKDIVLELLERIGADGATGYAIEFVGEAISALSVEGRMTLCNM 225
>LEU2_BACCR (Q81G10) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 464 Score = 95.1 bits (235), Expect = 2e-19 Identities = 53/156 (33%), Positives = 85/156 (54%) Frame = +2 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 D A + +D LR C++ ++ + D+ D + +G+ H+ + G +PG+ ++ Sbjct: 75 DRIAKQQLDTLRQNCKQFQVP----LADIGD-----EEQGIVHVIGPELGLTQPGKTIVC 125 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG ++ V+ T + P + L G++P + AKD+IL Sbjct: 126 GDSHTATHGAFGALAFGIGTSEVEHVLATQTLWQRKPKAMGIELKGKLPQGVYAKDIILH 185 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ + V+ T MEF G I ++ MEERMTLCNM Sbjct: 186 LLSKYGVAVGTGYVMEFYGEAIHAMDMEERMTLCNM 221
>LEU2_STAES (Q8CNL1) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 456 Score = 95.1 bits (235), Expect = 2e-19 Identities = 65/214 (30%), Positives = 105/214 (49%), Gaps = 6/214 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD------E 262 GE + +D+ + H+V P F+ ++ K+ + DH + T D E Sbjct: 20 GEPQLLYIDLHLIHEVTSPQA---FEGLRIQNRKLRRPDLTFATLDHNVPTIDIFNIKDE 76 Query: 263 RANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTD 442 AN+ + L +Q K F + F D +G+ H+ + G +PG+ ++ D Sbjct: 77 IANKQITTL-----QQNAKDF----GVHIFDMGSDEQGIVHMVGPETGLTQPGKTIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V T P ++ ++G +P + AKD+IL +I Sbjct: 128 SHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKININGSLPAGVYAKDIILYLI 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + V T ++EF G TI++L+ME RMT+CNM Sbjct: 188 NQYGVDFGTGYALEFTGETIKNLSMEARMTICNM 221
>LEU2_STAEQ (Q5HMF7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 456 Score = 95.1 bits (235), Expect = 2e-19 Identities = 65/214 (30%), Positives = 105/214 (49%), Gaps = 6/214 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD------E 262 GE + +D+ + H+V P F+ ++ K+ + DH + T D E Sbjct: 20 GEPQLLYIDLHLIHEVTSPQA---FEGLRIQNRKLRRPDLTFATLDHNVPTIDIFNIKDE 76 Query: 263 RANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTD 442 AN+ + L +Q K F + F D +G+ H+ + G +PG+ ++ D Sbjct: 77 IANKQITTL-----QQNAKDF----GVHIFDMGSDEQGIVHMVGPETGLTQPGKTIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V T P ++ ++G +P + AKD+IL +I Sbjct: 128 SHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKININGSLPAGVYAKDIILYLI 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + V T ++EF G TI++L+ME RMT+CNM Sbjct: 188 NQYGVDFGTGYALEFTGETIKNLSMEARMTICNM 221
>LEU2_MYCTU (O53237) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 473 Score = 94.7 bits (234), Expect = 3e-19 Identities = 66/208 (31%), Positives = 100/208 (48%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNV 280 +D+ + H+V P + +V E + DH + T AD + V Sbjct: 34 IDLHLVHEVTSPQAFDGLRLA---GRRVRRPELTLATEDHNVPTVDIDQPIADPVSRTQV 90 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 + LR C E I+ + + D +G+ H+ Q G +PG ++ DSHT Sbjct: 91 ETLRRNCAEFGIR----LHSMGDIE-----QGIVHVVGPQLGLTQPGMTIVCGDSHTSTH 141 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T L+ T+ +DG +P + AKD+IL +I +I Sbjct: 142 GAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPDGVSAKDIILALIAKIGTG 201 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 G +E+ GS IESL+ME RMT+CNM Sbjct: 202 GGQGHVIEYRGSAIESLSMEGRMTICNM 229
>LEU2_MYCBO (Q7TXH6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 473 Score = 94.7 bits (234), Expect = 3e-19 Identities = 66/208 (31%), Positives = 100/208 (48%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNV 280 +D+ + H+V P + +V E + DH + T AD + V Sbjct: 34 IDLHLVHEVTSPQAFDGLRLA---GRRVRRPELTLATEDHNVPTVDIDQPIADPVSRTQV 90 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 + LR C E I+ + + D +G+ H+ Q G +PG ++ DSHT Sbjct: 91 ETLRRNCAEFGIR----LHSMGDIE-----QGIVHVVGPQLGLTQPGMTIVCGDSHTSTH 141 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T L+ T+ +DG +P + AKD+IL +I +I Sbjct: 142 GAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPDGVSAKDIILALIAKIGTG 201 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 G +E+ GS IESL+ME RMT+CNM Sbjct: 202 GGQGHVIEYRGSAIESLSMEGRMTICNM 229
>LEU22_SALCH (Q57SN1) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 473 Score = 94.7 bits (234), Expect = 3e-19 Identities = 58/183 (31%), Positives = 95/183 (51%), Gaps = 11/183 (6%) Frame = +2 Query: 209 DREKVVIIPDHYIFTADE----RANRNV-------DILRDFCQEQKIKYFYDIKDLSDFR 355 +R + V PD ++ D R+ R+V + D+ +E + + D+ D R Sbjct: 48 ERGRAVRHPDTFLLNIDHVNPTRSQRDVLMTDPGGQLQVDYFRENAADFGITLFDVLDPR 107 Query: 356 ANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKAL 535 +G+ H+ ++G PG V+ DSHT GAFG GIG ++ ++ T + Sbjct: 108 -----QGIEHVVAHEQGLVMPGMVIAAGDSHTTTYGAFGALGFGIGTSEIEHLLATQTLV 162 Query: 536 LKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTL 715 + T+R + GE+P AKD++L+++ I GAT ++EFVG I +L++E RMTL Sbjct: 163 YRKLKTMRVSVQGELPFACSAKDIVLELLERIGADGATGYAIEFVGEAISALSVEGRMTL 222 Query: 716 CNM 724 CNM Sbjct: 223 CNM 225
>LEU2_ANASP (Q8YX02) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 467 Score = 94.7 bits (234), Expect = 3e-19 Identities = 63/204 (30%), Positives = 94/204 (46%), Gaps = 7/204 (3%) Frame = +2 Query: 134 MTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNVDILR 292 + H+V P + ++ KV E+ V DH + T D A + L Sbjct: 32 LVHEVTSPQAFAMLRER---GLKVLFPERTVATVDHIVPTENQARPFVDRLAEEMIQALE 88 Query: 293 DFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFG 472 CQE I FY+I +G+ H+ + G +PG + DSHT + GAFG Sbjct: 89 QNCQENNIT-FYNI--------GSGNQGIVHVIAPELGLTQPGMTIACGDSHTSSHGAFG 139 Query: 473 QFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATY 652 A GIG + V+ + L + ++G + P + AKD+IL II + V G Sbjct: 140 AIAFGIGTSQVRDVLASQTLSLSKLKVRKIEVNGALNPGVYAKDVILHIIRTLGVKGGVG 199 Query: 653 RSMEFVGSTIESLTMEERMTLCNM 724 + E+ G+T E + MEERMT+CNM Sbjct: 200 YAYEYAGTTFEQMNMEERMTVCNM 223
>LEU2_SYNP6 (Q5MZY3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 468 Score = 94.7 bits (234), Expect = 3e-19 Identities = 66/216 (30%), Positives = 102/216 (47%), Gaps = 7/216 (3%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------A 256 P + + + + H+V P + + G K R + DH + T A Sbjct: 20 PSGQTQLFIGLHLIHEVTSPQAFSMLRDR-GLTVKFPGRTVATV--DHIVPTENQARPFA 76 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 D A + L C+E I+ FY+I S +G+ H+ ++G +PG + Sbjct: 77 DSLAEEMIVTLERNCRENGIR-FYNIGSGS--------QGIVHVIAPEQGLTQPGMTIAC 127 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG + V+ + L + ++GE+ P + AKD+IL Sbjct: 128 GDSHTSTHGAFGAIAFGIGTSQVRDVLASQTLALSKLKVRKIEVNGELQPGVYAKDVILH 187 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 II ++ V G + EF GST +++MEERMT+CNM Sbjct: 188 IIRKLGVKGGVGYAYEFAGSTFAAMSMEERMTVCNM 223
>LEU2_BUCML (Q9EVG2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Fragment) Length = 442 Score = 94.4 bits (233), Expect = 3e-19 Identities = 58/201 (28%), Positives = 105/201 (52%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D+ + H+V P +Q+ V +K DH + T + N + + + Sbjct: 27 IDLHLLHEVTSPQAFYSLRQK---RRMVRQPKKTFATMDHNVSTHNRDINGSGSMAK--I 81 Query: 302 QEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFA 481 Q ++++ D ++S + N +G+ H+ ++G PG ++ DSHT GAFG + Sbjct: 82 QMEQLRKNCDEFNISLYDINNPNQGIVHVIAPEKGMTLPGMTIVCGDSHTSTHGAFGALS 141 Query: 482 TGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSM 661 GIG ++ V+ T + ++ + G++P ++ AKD+IL IIG+ S + + Sbjct: 142 FGIGTSEVEHVLATQTLKQQRFKNMKIEIIGQIPKFISAKDIILFIIGKXGSSIGSGYVV 201 Query: 662 EFVGSTIESLTMEERMTLCNM 724 EF G+ IE+++MEERMT+CNM Sbjct: 202 EFCGNVIETMSMEERMTICNM 222
>LEU2_ZYMMO (Q5NRC5) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 484 Score = 94.4 bits (233), Expect = 3e-19 Identities = 73/244 (29%), Positives = 115/244 (47%), Gaps = 14/244 (5%) Frame = +2 Query: 35 KSPMTTTEKIL-ARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWD 211 K+P T EKI A ER E G + + +D + H+V P +Q G + D Sbjct: 3 KNPRTLYEKIWDAHIVERR--EDGSAL-IYIDRHLVHEVTSPQAFEALRQA-GRPLRRPD 58 Query: 212 REKVVIIPDHYIFT-------------ADERANRNVDILRDFCQEQKIKYFYDIKDLSDF 352 R + +PDH + T AD ++ + + L E ++Y Sbjct: 59 R--TLAVPDHNVPTTARVDSEGHLLPIADPQSAKQLAALAKNAPEFGVRYI--------- 107 Query: 353 RANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKA 532 A +G+ H+ ++G PG L+ DSHT GA G A GIG ++ VM T Sbjct: 108 SATDPEQGIVHVVGPEQGFTLPGTTLVCGDSHTAAHGALGALAFGIGTSEVEHVMATQTL 167 Query: 533 LLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMT 712 +L T+ ++G++ P + AKDLIL II + +G T ++E+ G I +L++EER+T Sbjct: 168 ILTPAKTMEVRVEGKLSPDVSAKDLILHIIHSLGTAGGTGYAIEYTGEAIRNLSIEERLT 227 Query: 713 LCNM 724 + NM Sbjct: 228 VSNM 231
>LEU21_BRAJA (Q89X98) 3-isopropylmalate dehydratase large subunit 1 (EC| 4.2.1.33) (Isopropylmalate isomerase 1) (Alpha-IPM isomerase 1) (IPMI 1) Length = 477 Score = 94.4 bits (233), Expect = 3e-19 Identities = 63/204 (30%), Positives = 98/204 (48%), Gaps = 3/204 (1%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANR---NVDILR 292 VD + HD+ G + K + V + E PDH I TA RA ++L Sbjct: 38 VDRHLLHDLGGSRGLIDLKSR---NLPVHNPELTFATPDHAISTASGRAGTITTGQELLA 94 Query: 293 DFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFG 472 E + F + +G+ H+ + G PG +++ DSHTC G G Sbjct: 95 ALRTETSAS------GIRLFDIDQPGQGIVHVIGPELGLSLPGCLIVCGDSHTCTHGGLG 148 Query: 473 QFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATY 652 A GIG+++ V+ T + + P T+R DG MP + AKDLIL +IG + +G T Sbjct: 149 ALAFGIGSSELTHVLATQTIIQRRPKTMRVTFDGRMPFGVTAKDLILALIGHVGAAGGTG 208 Query: 653 RSMEFVGSTIESLTMEERMTLCNM 724 ++E+ GS I + +E R+T+CN+ Sbjct: 209 YAVEYAGSAIRGMPIEGRLTICNL 232
>LEU2_BACHK (Q6HLF1) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 464 Score = 94.4 bits (233), Expect = 3e-19 Identities = 69/231 (29%), Positives = 114/231 (49%), Gaps = 8/231 (3%) Frame = +2 Query: 56 EKILARASERASLEPGENVW--VDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVI 229 +++L + ER + EN + +D+ + H+V P F+ + KV + Sbjct: 3 KRLLDKLWERHVVTTNENGLDLLYIDLHLVHEVTSPQA---FEGLRLTNRKVRRPDLTFA 59 Query: 230 IPDHYIFT------ADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIA 391 DH I T D A + +D LR C++ ++ + D+ D + +G+ H+ Sbjct: 60 TMDHNIPTKDVWNITDRIAKQQLDTLRANCKQFQVP----LADIGD-----EEQGIVHVI 110 Query: 392 LAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLD 571 + G +PG+ ++ DSHT GAFG A GIG ++ V+ T + P + L Sbjct: 111 GPELGLTQPGKTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLWQRKPKAMGIELK 170 Query: 572 GEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G++ + AKD+IL ++ + V+ T MEF G TI ++ MEERMTLCNM Sbjct: 171 GKLQKGVYAKDIILHLLSKYGVAVGTGYVMEFYGETIGAMEMEERMTLCNM 221
>LEU2_BACFR (Q64QP1) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 464 Score = 94.4 bits (233), Expect = 3e-19 Identities = 64/208 (30%), Positives = 100/208 (48%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER-------ANRNV 280 +D L H+V P + KV+ EKV +PDH T D+ + V Sbjct: 26 IDRLYCHEVTSPQAFAGLR---ARGIKVFRPEKVYCMPDHNTPTHDQDKPIEDPVSKTQV 82 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 D L + + ++ + D R G+ H+ + G PG ++ DSHT Sbjct: 83 DTLTKNAADFGLTHY----GMMDKR-----NGIIHVVGPERGLTLPGMTIVCGDSHTSTH 133 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GA G A GIG ++ V+ + L P T+R +DG++ + AKD+ L ++ +++ S Sbjct: 134 GAMGAVAFGIGTSEVEMVLASQCILQSRPKTMRITVDGKLGKGVTAKDIALYMMSKMTTS 193 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 GAT +E+ G I SLTME R+TLCN+ Sbjct: 194 GATGYFVEYAGEAIRSLTMEGRLTLCNL 221
>LEU2_BACFN (Q5LAB1) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 464 Score = 94.4 bits (233), Expect = 3e-19 Identities = 64/208 (30%), Positives = 100/208 (48%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER-------ANRNV 280 +D L H+V P + KV+ EKV +PDH T D+ + V Sbjct: 26 IDRLYCHEVTSPQAFAGLR---ARGIKVFRPEKVYCMPDHNTPTHDQDKPIEDPVSKTQV 82 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 D L + + ++ + D R G+ H+ + G PG ++ DSHT Sbjct: 83 DTLTKNAADFGLTHY----GMMDKR-----NGIIHVVGPERGLTLPGMTIVCGDSHTSTH 133 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GA G A GIG ++ V+ + L P T+R +DG++ + AKD+ L ++ +++ S Sbjct: 134 GAMGAVAFGIGTSEVEMVLASQCILQSRPKTMRITVDGKLGKGVTAKDIALYMMSKMTTS 193 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 GAT +E+ G I SLTME R+TLCN+ Sbjct: 194 GATGYFVEYAGEAIRSLTMEGRLTLCNL 221
>LEU2_BUCDN (O85072) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 94.4 bits (233), Expect = 3e-19 Identities = 62/203 (30%), Positives = 105/203 (51%), Gaps = 2/203 (0%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 VD+ + H+V P F+ +D V +K DH + T + N + + + Sbjct: 27 VDLHLLHEVTSPQA---FESLRIKDRTVRQPKKTFATMDHNVSTESKDINASGSMAKIQM 83 Query: 302 QE--QKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQ 475 Q+ + K F+ +S + N +G+ H+ ++G PG V++ DSHT GAFG Sbjct: 84 QQLIKNCKEFH----ISLYDLNHPNQGIVHVISPEQGMTLPGMVIVCGDSHTSTHGAFGA 139 Query: 476 FATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYR 655 + GIG ++ V+ T + ++ + G++ ++ AKD+IL IIG+I S T Sbjct: 140 LSFGIGTSEVEHVLATQTLKQQRFKNMKIEVIGKIGNFITAKDVILYIIGKIGSSAGTGY 199 Query: 656 SMEFVGSTIESLTMEERMTLCNM 724 +EF G+ I+ ++MEERMT+CNM Sbjct: 200 IIEFCGNVIKKMSMEERMTVCNM 222
>LEU2_BLOFL (Q7VQJ8) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 94.4 bits (233), Expect = 3e-19 Identities = 64/203 (31%), Positives = 103/203 (50%), Gaps = 2/203 (0%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D + H+V P F+ ++ K+ K DH + T + N+ + Sbjct: 27 IDRHLLHEVTSPQA---FESIRFKNRKIRRPNKTFATMDHNVPTIMQ----NIHSIEGMS 79 Query: 302 QEQKIKYFYDIKD--LSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQ 475 + Q + + KD ++ F + ++G+ H+ ++G PG ++ DSHT GAFG Sbjct: 80 KIQLNQLTKNCKDFNITLFDLSHPHQGIIHVLAPEQGIILPGMTVVCGDSHTSTHGAFGA 139 Query: 476 FATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYR 655 + GIG ++ V+ T ++ L G +PPY+ AKDLIL IIG+I GA+ Sbjct: 140 LSFGIGTSEIEHVLVTQTLRQPKYKSMGINLFGTIPPYITAKDLILFIIGKIGHGGASGY 199 Query: 656 SMEFVGSTIESLTMEERMTLCNM 724 +EF G I +L+MEERMT+CNM Sbjct: 200 IVEFYGDVINTLSMEERMTICNM 222
>LEU2_SILPO (Q5LX06) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 468 Score = 94.4 bits (233), Expect = 3e-19 Identities = 62/210 (29%), Positives = 98/210 (46%), Gaps = 9/210 (4%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD---------ERANR 274 +D + H+V P + KV EK + +PDH + T + E + Sbjct: 28 IDRHLVHEVTSPQAFEGLRMA---GRKVRAPEKTIAVPDHNVPTTEGREDPAQMTEESRI 84 Query: 275 NVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTC 454 V L +E + Y Y + D+ +G+ HI ++G PG ++ DSHT Sbjct: 85 QVQALDKNAREFGVHY-YPVDDIR--------QGIVHIVGPEQGWTLPGMTVVCGDSHTA 135 Query: 455 NAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEIS 634 GAFG A GIG ++ V+ T + K ++ + G++ P + AKD+ L +IG Sbjct: 136 THGAFGALAHGIGTSEVEHVLATQTLIQKKSKNMKVEITGKLNPGVTAKDITLAVIGATG 195 Query: 635 VSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +G T +E+ G I L+ME RMT+CNM Sbjct: 196 TAGGTGYVIEYCGEAIRDLSMEGRMTVCNM 225
>LEU2_STAHJ (Q4L7U2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 456 Score = 94.4 bits (233), Expect = 3e-19 Identities = 64/214 (29%), Positives = 105/214 (49%), Gaps = 6/214 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD------E 262 GE + +D+ + H+V P F+ ++ K+ + DH + T D E Sbjct: 20 GEPQLLYIDLHLIHEVTSPQA---FEGLRLQNRKLRRPDLTFATLDHNVPTIDIFNIKDE 76 Query: 263 RANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTD 442 AN+ + L+ +E ++ F D+ +G+ H+ + G +PG+ ++ D Sbjct: 77 IANKQITTLQKNAKEFGVQLF----DMGSVE-----QGIVHMVGPETGLTQPGKTIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V T P ++ + G++P + AKD+IL +I Sbjct: 128 SHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKIDVTGQLPKGVYAKDIILYLI 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + V T ++EF G TI SL+ME RMT+CNM Sbjct: 188 SQYGVDFGTGYAIEFTGETIRSLSMEARMTICNM 221
>LEU2_LISMO (Q8Y5R7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 462 Score = 94.4 bits (233), Expect = 3e-19 Identities = 64/214 (29%), Positives = 109/214 (50%), Gaps = 6/214 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER----- 265 GE + VD+ + H+V P F+ E+ + +K DH + T D Sbjct: 20 GEPQLLYVDLHLIHEVTSPQA---FEGLRLENRPLRRPDKTFATMDHNVPTEDIFNIQDL 76 Query: 266 -ANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTD 442 A + ++ L+ C E + L+D + D +G+ H+ + G +PG+V++ D Sbjct: 77 VAKKQIEALQTNCAEFGVT-------LADMGS--DRQGIVHMVGPETGLTQPGKVIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG GIG+++ V T + P ++ ++G++P + AKD+IL +I Sbjct: 128 SHTATHGAFGAIGFGIGSSEVEHVFATQTIWQQKPKSMGIEINGKLPKGVYAKDIILHLI 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 V+ T ++E+ G TI +++MEERMT+CNM Sbjct: 188 ATYGVAFGTGYAVEYYGETIRNMSMEERMTICNM 221
>LEU2_CORJK (Q4JUX2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 473 Score = 94.0 bits (232), Expect = 4e-19 Identities = 73/239 (30%), Positives = 109/239 (45%), Gaps = 11/239 (4%) Frame = +2 Query: 41 PMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREK 220 P+T EK+ R A+ E G + +D+ + H+V P +Q KV + Sbjct: 5 PLTLAEKVW-RDHIVAAGENGGPDLLYIDLHLVHEVTSPQAFDGLRQA---GRKVRRPDL 60 Query: 221 VVIIPDHYIFTA-----------DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPD 367 + DH + T + + V LRD +E I+ + + D Sbjct: 61 TIATEDHNVPTIGVKTGDLQEIQEPTSRLQVSTLRDNAKEFGIR----LHSMGDIE---- 112 Query: 368 YKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVP 547 +G+ H Q G +PG ++ DSHT GAFG A GIG ++ V+ T LK Sbjct: 113 -QGIVHTVGPQLGLTQPGMTVVCGDSHTSTHGAFGSIAMGIGTSEVEHVLATQTLPLKPF 171 Query: 548 PTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 T+ + GE+ P + +KDLIL II +I G +E+ G IE L+ME RMT+CNM Sbjct: 172 KTMAIEVSGELQPDVTSKDLILAIIAKIGTGGGQGHIIEYRGEAIEKLSMEARMTMCNM 230
>LEU2_GEOKA (Q5KWJ5) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 471 Score = 94.0 bits (232), Expect = 4e-19 Identities = 66/216 (30%), Positives = 103/216 (47%), Gaps = 6/216 (2%) Frame = +2 Query: 95 EPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTA------ 256 E G+ + +D+ + H+V P +Q+ KV + DH + T Sbjct: 19 EEGKPDLLYIDLHLVHEVTSPQAFEGLRQK---GRKVRRPDLTFATMDHNVPTVNRFVIT 75 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 DE A + L C+E I L+D + + +G+ H+ + G +PG+ ++ Sbjct: 76 DEVARNQIAALERNCREFGIP-------LADLHS--EEQGIVHVIGPELGLTQPGKTIVC 126 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG ++ V+ T P T++ ++G + + AKD+IL Sbjct: 127 GDSHTSTHGAFGALAFGIGTSEVEHVLATQTLWQHKPKTLQICINGRLGKGVTAKDVILA 186 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 IIG V T +EF G I ++MEERMT+CNM Sbjct: 187 IIGRYGVGVGTGYIIEFTGEAIRRMSMEERMTICNM 222
>LEU2_BACSU (P80858) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Superoxide-inducible protein 10) (SOI10) Length = 472 Score = 94.0 bits (232), Expect = 4e-19 Identities = 64/207 (30%), Positives = 100/207 (48%), Gaps = 6/207 (2%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTA------DERANRNVD 283 +D+ + H+V P +Q+ KV + DH I T DE A R V Sbjct: 28 IDLHLIHEVTSPQAFEGLRQK---GRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVT 84 Query: 284 ILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAG 463 L C+E ++ L+D + +G+ H+ + G PG+ ++ DSHT G Sbjct: 85 ALERNCEEFGVR-------LADLHSVD--QGIVHVVGPELGLTLPGKTIVCGDSHTSTHG 135 Query: 464 AFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSG 643 AFG A GIG ++ V+ T + P T+ +DG + + AKD+IL +IG+ V Sbjct: 136 AFGALAFGIGTSEVEHVLSTQTLWQQRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKF 195 Query: 644 ATYRSMEFVGSTIESLTMEERMTLCNM 724 T +E+ G ++TM+ERMT+CNM Sbjct: 196 GTGYVIEYTGEVFRNMTMDERMTVCNM 222
>LEU2_BACLD (Q65GJ0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 472 Score = 94.0 bits (232), Expect = 4e-19 Identities = 64/207 (30%), Positives = 101/207 (48%), Gaps = 6/207 (2%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTA------DERANRNVD 283 +D+ + H+V P +Q+ + KV + DH I T D+ A R V Sbjct: 28 IDLHLIHEVTSPQAFEGLRQK---NRKVRRPQNTFATMDHNIPTVNRFEIKDDVAKRQVS 84 Query: 284 ILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAG 463 L C+E I+ + DLS +G+ H+ + G PG+ ++ DSHT G Sbjct: 85 ALERNCEEFGIR----LADLSSVD-----QGIVHVIGPELGLTLPGKTIVCGDSHTSTHG 135 Query: 464 AFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSG 643 AFG A GIG ++ V+ T + P T+ +DG++ + AKD+IL IIG+ V Sbjct: 136 AFGALAFGIGTSEVEHVLSTQTLWQQKPKTLEIRVDGKLQKGVTAKDVILAIIGKYGVKF 195 Query: 644 ATYRSMEFVGSTIESLTMEERMTLCNM 724 +E+ G +++M+ERMT+CNM Sbjct: 196 GAGYVIEYTGEVFRNMSMDERMTVCNM 222
>LEU2_BACAN (Q81T66) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 464 Score = 94.0 bits (232), Expect = 4e-19 Identities = 53/156 (33%), Positives = 86/156 (55%) Frame = +2 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 D A + +D LR+ C++ ++ + D+ D + +G+ H+ + G +PG+ ++ Sbjct: 75 DRIAKQQLDTLRENCKQFQVP----LADIGD-----EEQGIVHVIGPELGLTQPGKTIVC 125 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG ++ V+ T + P + L G++ + AKD+IL Sbjct: 126 GDSHTATHGAFGALAFGIGTSEVEHVLATQTLWQRKPKAMGIELKGKLQKGVYAKDIILH 185 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ + V+ T MEF G TI ++ MEERMTLCNM Sbjct: 186 LLSKYGVAVGTGYVMEFYGETIGTMEMEERMTLCNM 221
>LEU2_YEAST (P07264) 3-isopropylmalate dehydratase (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 779 Score = 93.6 bits (231), Expect = 6e-19 Identities = 58/163 (35%), Positives = 86/163 (52%) Frame = +2 Query: 236 DHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCR 415 D +I D R V L + ++ + YF +SD R +G+ H +EG Sbjct: 84 DTFIKQTDSRLQ--VKTLENNVKQFGVPYF----GMSDAR-----QGIVHTIGPEEGFTL 132 Query: 416 PGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLL 595 PG ++ DSHT GAFG A GIG ++ V+ T + +R ++G++ P + Sbjct: 133 PGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTIIQAKSKNMRITVNGKLSPGIT 192 Query: 596 AKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +KDLIL IIG I +G T +EF G IE+L+ME RM++CNM Sbjct: 193 SKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSMEARMSMCNM 235
>LEU2_BACHD (Q9K8F0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 472 Score = 93.6 bits (231), Expect = 6e-19 Identities = 73/235 (31%), Positives = 112/235 (47%), Gaps = 6/235 (2%) Frame = +2 Query: 38 SPMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDRE 217 +P T EKI + E G+ + +D+ M H+V P + G + D Sbjct: 2 APKTIIEKIWD--AHTVIGEEGKPSLLYIDLHMVHEVTSPQAFEGLRLA-GRPVRRPDLT 58 Query: 218 KVVIIPDHYIFTAD------ERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGV 379 + DH + T D + A + ++ L C+E I +I L +P+ G+ Sbjct: 59 FATM--DHNVPTVDRFNIQDQIARKQIETLEANCKEFGI----EIAGLD----SPN-NGI 107 Query: 380 CHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIR 559 H+ + G +PG+ ++ DSHT GAFG A GIG ++ V+ T P T+ Sbjct: 108 VHVIGPELGLTQPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLWQSKPKTME 167 Query: 560 FVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + GE+ P + AKD+IL +I + V T +EF G I SL+MEERMT+CNM Sbjct: 168 VRVTGELAPSVSAKDIILAVIAKYGVDFGTGHVIEFTGEAIRSLSMEERMTICNM 222
>LEU2_GLUOX (Q5FUG3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 475 Score = 93.6 bits (231), Expect = 6e-19 Identities = 72/237 (30%), Positives = 111/237 (46%), Gaps = 8/237 (3%) Frame = +2 Query: 38 SPMTTTEKILA-RASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDR 214 SP T +KI ER LE G + + +D + H+V P + +V Sbjct: 6 SPRTLFDKIWDDHVVER--LEDGTCI-LYIDRHLVHEVTSPQAFEGLRMS---GRRVRRP 59 Query: 215 EKVVIIPDHYIFTADE-------RANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYK 373 + V + DH + T+D ++ ++ L E + YF ++ S + Sbjct: 60 DATVAVADHNVPTSDRSKPIEEPQSRLQIETLEKNVAEFGVPYF-PLRSAS--------Q 110 Query: 374 GVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPT 553 G+ H+ ++G PG ++ DSHT GA G A GIG ++ V+ T L K Sbjct: 111 GIVHVVGPEQGISLPGMTIVCGDSHTSTHGALGSLAFGIGTSEVEHVLATQTILQKPAKN 170 Query: 554 IRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +R ++G++ P + AKD++L IIG I +G T +EF GS I L M RMTLCNM Sbjct: 171 MRVSVEGKVGPGVTAKDILLAIIGRIGTAGGTGHVIEFAGSAIRDLDMAGRMTLCNM 227
>LEU2_BUCUL (Q9AQC6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Fragment) Length = 369 Score = 93.2 bits (230), Expect = 7e-19 Identities = 53/153 (34%), Positives = 86/153 (56%) Frame = +2 Query: 266 ANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDS 445 A + ++ L C E I YDI NP+ +G+ H+ ++G PG +++ DS Sbjct: 6 ARKQMEQLIKNCDEFNIS-LYDIN-------NPN-QGIVHVIAPEKGMTLPGMIIVCGDS 56 Query: 446 HTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIG 625 HT GAFG + GIG ++ V+ T + ++ + G++P ++ AKD+IL +IG Sbjct: 57 HTSTHGAFGALSFGIGTSEVEHVLATQTLKQQRFKNMKIEIIGDVPQFVTAKDIILFVIG 116 Query: 626 EISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + SG T +EF G+ I+ ++MEERMT+CNM Sbjct: 117 RLGSSGGTGYVIEFCGNVIKKMSMEERMTVCNM 149
>LEU2_VIBVY (Q7MP79) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 93.2 bits (230), Expect = 7e-19 Identities = 65/215 (30%), Positives = 102/215 (47%), Gaps = 7/215 (3%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------AD 259 GE + +D + H+V P +++ + +V K DH + T + Sbjct: 20 GETPILYIDRHLVHEVTSPQAFDGLREKGRQVRQV---SKTFATMDHNVSTTTKDINASG 76 Query: 260 ERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGT 439 E A ++ L CQE + YDI N Y+G+ H+ + G PG ++ Sbjct: 77 EMARIQMETLIKNCQEFGVT-LYDI--------NHKYQGIVHVMGPELGITLPGMTIVCG 127 Query: 440 DSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQI 619 DSHT GAFG A GIG ++ V+ T T++ + G++ + AKD++L I Sbjct: 128 DSHTATHGAFGSLAFGIGTSEVEHVLATQTLKQARAKTMKIEVQGKVADGITAKDIVLAI 187 Query: 620 IGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 IG+ + +G T +EF G I L+ME RMT+CNM Sbjct: 188 IGKTTAAGGTGYVVEFCGEAITDLSMEGRMTVCNM 222
>LEU2_VIBVU (Q8DED9) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 93.2 bits (230), Expect = 7e-19 Identities = 65/215 (30%), Positives = 102/215 (47%), Gaps = 7/215 (3%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------AD 259 GE + +D + H+V P +++ + +V K DH + T + Sbjct: 20 GETPILYIDRHLVHEVTSPQAFDGLREKGRQVRQV---SKTFATMDHNVSTTTKDINASG 76 Query: 260 ERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGT 439 E A ++ L CQE + YDI N Y+G+ H+ + G PG ++ Sbjct: 77 EMARIQMETLIKNCQEFGVT-LYDI--------NHKYQGIVHVMGPELGITLPGMTIVCG 127 Query: 440 DSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQI 619 DSHT GAFG A GIG ++ V+ T T++ + G++ + AKD++L I Sbjct: 128 DSHTATHGAFGSLAFGIGTSEVEHVLATQTLKQARAKTMKIEVQGKVADGITAKDIVLAI 187 Query: 620 IGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 IG+ + +G T +EF G I L+ME RMT+CNM Sbjct: 188 IGKTTAAGGTGYVVEFCGEAITDLSMEGRMTVCNM 222
>LEU2_STAS1 (Q49Z14) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 456 Score = 93.2 bits (230), Expect = 7e-19 Identities = 54/156 (34%), Positives = 83/156 (53%) Frame = +2 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 DE AN+ + L ++ K F + F D +G+ H+ + G +PG+ ++ Sbjct: 75 DEIANKQITTL-----QKNAKAF----GVHIFDMGSDEQGIVHMVGPETGLTQPGKTIVC 125 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG ++ V T P ++ ++G++P + AKD+IL Sbjct: 126 GDSHTATHGAFGAIAFGIGTSEVEHVFATQSLWQTKPKNLKIEVNGKLPTGVYAKDIILH 185 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +I + V T ++EF G TI SL+ME RMT+CNM Sbjct: 186 LINQHGVDFGTGYALEFSGETIRSLSMEARMTICNM 221
>LEU2_PHOLL (Q7N127) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 92.8 bits (229), Expect = 1e-18 Identities = 64/214 (29%), Positives = 101/214 (47%), Gaps = 5/214 (2%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRN 277 P E + +D + H+V P + + V K DH + T + N Sbjct: 19 PNETPLLYIDRHLVHEVTSPQAFDGLRTK---GRPVHQPGKTFATMDHNVSTQTKDINAC 75 Query: 278 VDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQEGHCRPGEVLLGTD 442 D+ R QE +K+ ++F N Y+G+ H+ ++G PG ++ D Sbjct: 76 GDMARIQMQEL-------MKNCAEFGITLYDLNHPYQGIVHVIGPEQGITLPGMTIVCGD 128 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V+ + T++ + G++ + AKD++L II Sbjct: 129 SHTATHGAFGSLAFGIGTSEVEHVLASQTLKQARAKTMKIEVMGDVGDAITAKDIVLAII 188 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G+ +G T +EF G IE+L+ME RMTLCNM Sbjct: 189 GKTGSAGGTGYVVEFCGKAIEALSMEGRMTLCNM 222
>LEU2_STAAW (P58947) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 456 Score = 92.8 bits (229), Expect = 1e-18 Identities = 64/214 (29%), Positives = 105/214 (49%), Gaps = 6/214 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD------E 262 GE + +D+ + H+V P F+ ++ K+ + DH + T D E Sbjct: 20 GEPQLLYIDLHLIHEVTSPQA---FEGLRLQNRKLRRPDLTFATLDHNVPTIDIFNIKDE 76 Query: 263 RANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTD 442 AN+ + L Q+ I + I D+ D +G+ H+ + G +PG+ ++ D Sbjct: 77 IANKQITTL----QKNAIDFGVHIFDMGS-----DEQGIVHMVGPETGLTQPGKTIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V T P ++ ++G +P + AKD+IL +I Sbjct: 128 SHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKIDINGTLPTGVYAKDIILHLI 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 V T ++EF G TI++L+M+ RMT+CNM Sbjct: 188 KTYGVDFGTGYALEFTGETIKNLSMDGRMTICNM 221
>LEU2_STAAS (Q6G7P9) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 456 Score = 92.8 bits (229), Expect = 1e-18 Identities = 64/214 (29%), Positives = 105/214 (49%), Gaps = 6/214 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD------E 262 GE + +D+ + H+V P F+ ++ K+ + DH + T D E Sbjct: 20 GEPQLLYIDLHLIHEVTSPQA---FEGLRLQNRKLRRPDLTFATLDHNVPTIDIFNIKDE 76 Query: 263 RANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTD 442 AN+ + L Q+ I + I D+ D +G+ H+ + G +PG+ ++ D Sbjct: 77 IANKQITTL----QKNAIDFGVHIFDMGS-----DEQGIVHMVGPETGLTQPGKTIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V T P ++ ++G +P + AKD+IL +I Sbjct: 128 SHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKIDINGTLPTGVYAKDIILHLI 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 V T ++EF G TI++L+M+ RMT+CNM Sbjct: 188 KTYGVDFGTGYALEFTGETIKNLSMDGRMTICNM 221
>LEU2_STAAN (P63436) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 456 Score = 92.8 bits (229), Expect = 1e-18 Identities = 64/214 (29%), Positives = 105/214 (49%), Gaps = 6/214 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD------E 262 GE + +D+ + H+V P F+ ++ K+ + DH + T D E Sbjct: 20 GEPQLLYIDLHLIHEVTSPQA---FEGLRLQNRKLRRPDLTFATLDHNVPTIDIFNIKDE 76 Query: 263 RANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTD 442 AN+ + L Q+ I + I D+ D +G+ H+ + G +PG+ ++ D Sbjct: 77 IANKQITTL----QKNAIDFGVHIFDMGS-----DEQGIVHMVGPETGLTQPGKTIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V T P ++ ++G +P + AKD+IL +I Sbjct: 128 SHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKIDINGTLPTGVYAKDIILHLI 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 V T ++EF G TI++L+M+ RMT+CNM Sbjct: 188 KTYGVDFGTGYALEFTGETIKNLSMDGRMTICNM 221
>LEU2_STAAM (P63435) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 456 Score = 92.8 bits (229), Expect = 1e-18 Identities = 64/214 (29%), Positives = 105/214 (49%), Gaps = 6/214 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD------E 262 GE + +D+ + H+V P F+ ++ K+ + DH + T D E Sbjct: 20 GEPQLLYIDLHLIHEVTSPQA---FEGLRLQNRKLRRPDLTFATLDHNVPTIDIFNIKDE 76 Query: 263 RANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTD 442 AN+ + L Q+ I + I D+ D +G+ H+ + G +PG+ ++ D Sbjct: 77 IANKQITTL----QKNAIDFGVHIFDMGS-----DEQGIVHMVGPETGLTQPGKTIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V T P ++ ++G +P + AKD+IL +I Sbjct: 128 SHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKIDINGTLPTGVYAKDIILHLI 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 V T ++EF G TI++L+M+ RMT+CNM Sbjct: 188 KTYGVDFGTGYALEFTGETIKNLSMDGRMTICNM 221
>LEU2_STAAC (Q5HEE2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 456 Score = 92.8 bits (229), Expect = 1e-18 Identities = 64/214 (29%), Positives = 105/214 (49%), Gaps = 6/214 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD------E 262 GE + +D+ + H+V P F+ ++ K+ + DH + T D E Sbjct: 20 GEPQLLYIDLHLIHEVTSPQA---FEGLRLQNRKLRRPDLTFATLDHNVPTIDIFNIKDE 76 Query: 263 RANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTD 442 AN+ + L Q+ I + I D+ D +G+ H+ + G +PG+ ++ D Sbjct: 77 IANKQITTL----QKNAIDFGVHIFDMGS-----DEQGIVHMVGPETGLTQPGKTIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V T P ++ ++G +P + AKD+IL +I Sbjct: 128 SHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKIDINGTLPTGVYAKDIILHLI 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 V T ++EF G TI++L+M+ RMT+CNM Sbjct: 188 KTYGVDFGTGYALEFTGETIKNLSMDGRMTICNM 221
>LEU2_STAAR (Q6GF14) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 455 Score = 92.8 bits (229), Expect = 1e-18 Identities = 64/214 (29%), Positives = 105/214 (49%), Gaps = 6/214 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD------E 262 GE + +D+ + H+V P F+ ++ K+ + DH + T D E Sbjct: 20 GEPQLLYIDLHLIHEVTSPQA---FEGLRLQNRKLRRPDLTFATLDHNVPTIDIFNIKDE 76 Query: 263 RANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTD 442 AN+ + L Q+ I + I D+ D +G+ H+ + G +PG+ ++ D Sbjct: 77 IANKQITTL----QKNAIDFGVHIFDMGS-----DEQGIVHMVGPETGLTQPGKTIVCGD 127 Query: 443 SHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQII 622 SHT GAFG A GIG ++ V T P ++ ++G +P + AKD+IL +I Sbjct: 128 SHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKIDINGTLPTGVYAKDIILHLI 187 Query: 623 GEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 V T ++EF G TI++L+M+ RMT+CNM Sbjct: 188 KTYGVDFGTGYALEFTGETIKNLSMDGRMTICNM 221
>LEU2_RHIRA (P17279) 3-isopropylmalate dehydratase (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 644 Score = 92.4 bits (228), Expect = 1e-18 Identities = 58/171 (33%), Positives = 87/171 (50%), Gaps = 8/171 (4%) Frame = +2 Query: 236 DHYIFTADERANRNVDIL------RDFCQ--EQKIKYFYDIKDLSDFRANPDYKGVCHIA 391 DH I T + +N+ R C+ EQ I+ F L+ F +G+ H+ Sbjct: 109 DHNIPTTTRKIFKNITTFIKEADSRTQCETLEQNIEAF----GLTYFGMEDSRQGIVHVI 164 Query: 392 LAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLD 571 ++G P ++ DSHT GAFG A GIG ++ V+ T L K +R + Sbjct: 165 GPEQGFTLPATTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLLQKKSKNMRIRVQ 224 Query: 572 GEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G+ P + +KD++L IIG I +G T +EF G TI +L+ME RM++CNM Sbjct: 225 GKALPGVTSKDIVLHIIGVIGTAGGTGCVIEFCGDTIAALSMESRMSICNM 275
>LEU2_SHISS (Q3Z5T8) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 92.4 bits (228), Expect = 1e-18 Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 5/206 (2%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D + H+V P + V K DH + T + N ++ R Sbjct: 27 IDRHLVHEVTSPQAFNGLR---AHGRPVRQPGKTFATMDHNVSTQTKDINACGEMARIQM 83 Query: 302 QEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGA 466 QE IK+ +F N Y+G+ H+ ++G PG ++ DSHT GA Sbjct: 84 QEL-------IKNCKEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGA 136 Query: 467 FGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGA 646 FG A GIG ++ V+ T T++ + G+ P + AKD++L IIG+ +G Sbjct: 137 FGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKAAPGITAKDIVLAIIGKTGSAGG 196 Query: 647 TYRSMEFVGSTIESLTMEERMTLCNM 724 T +EF G I L+ME RMTLCNM Sbjct: 197 TGHVVEFCGEAIRDLSMEGRMTLCNM 222
>LEU2_ECOLI (P0A6A6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 465 Score = 92.0 bits (227), Expect = 2e-18 Identities = 57/168 (33%), Positives = 84/168 (50%), Gaps = 5/168 (2%) Frame = +2 Query: 236 DHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQ 400 DH + T + N ++ R QE IK+ +F N Y+G+ H+ + Sbjct: 61 DHNVSTQTKDINACGEMARIQMQEL-------IKNCKEFGVELYDLNHPYQGIVHVMGPE 113 Query: 401 EGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEM 580 +G PG ++ DSHT GAFG A GIG ++ V+ T T++ + G+ Sbjct: 114 QGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKA 173 Query: 581 PPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P + AKD++L IIG+ +G T +EF G I L+ME RMTLCNM Sbjct: 174 APGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNM 221
>LEU2_ECOL6 (P0A6A7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 465 Score = 92.0 bits (227), Expect = 2e-18 Identities = 57/168 (33%), Positives = 84/168 (50%), Gaps = 5/168 (2%) Frame = +2 Query: 236 DHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQ 400 DH + T + N ++ R QE IK+ +F N Y+G+ H+ + Sbjct: 61 DHNVSTQTKDINACGEMARIQMQEL-------IKNCKEFGVELYDLNHPYQGIVHVMGPE 113 Query: 401 EGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEM 580 +G PG ++ DSHT GAFG A GIG ++ V+ T T++ + G+ Sbjct: 114 QGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKA 173 Query: 581 PPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P + AKD++L IIG+ +G T +EF G I L+ME RMTLCNM Sbjct: 174 APGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNM 221
>LEU2_ECO57 (Q8XA00) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 465 Score = 92.0 bits (227), Expect = 2e-18 Identities = 57/168 (33%), Positives = 84/168 (50%), Gaps = 5/168 (2%) Frame = +2 Query: 236 DHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQ 400 DH + T + N ++ R QE IK+ +F N Y+G+ H+ + Sbjct: 61 DHNVSTQTKDINACGEMARIQMQEL-------IKNCKEFGVELYDLNHPYQGIVHVMGPE 113 Query: 401 EGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEM 580 +G PG ++ DSHT GAFG A GIG ++ V+ T T++ + G+ Sbjct: 114 QGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKA 173 Query: 581 PPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P + AKD++L IIG+ +G T +EF G I L+ME RMTLCNM Sbjct: 174 APGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNM 221
>LEU2_COLP3 (Q47WG2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 471 Score = 92.0 bits (227), Expect = 2e-18 Identities = 69/234 (29%), Positives = 107/234 (45%), Gaps = 2/234 (0%) Frame = +2 Query: 29 SVKSPMTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVW 208 + +P T EK+ A+ GE + VD + H+V P + + V Sbjct: 2 TTSTPQTMYEKLWQTHLVEAT--KGETPLLYVDRHLIHEVTSPQAFANLRFH---NRPVR 56 Query: 209 DREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKD--LSDFRANPDYKGVC 382 E+ + DH I T + +D + Q + KD + F +G+ Sbjct: 57 HPERTIATMDHNISTRSIK----IDAAGEGAANQLRALAINCKDFGIELFDMGHKNQGIA 112 Query: 383 HIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRF 562 H+ + G PG +++ DSHT GAFG A GIG ++ V T T++ Sbjct: 113 HVIGPELGLTLPGTIIVCGDSHTATHGAFGALAFGIGTSEVEHVFATQTLRQNKAKTMKI 172 Query: 563 VLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + G + + AKD+IL IIG+ +GAT +E+ G IE+L+MEERMT+CNM Sbjct: 173 EVKGHVGAGISAKDIILAIIGKTGSAGATGYVVEYCGEAIEALSMEERMTVCNM 226
>LEU2_SHIFL (Q821C2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 92.0 bits (227), Expect = 2e-18 Identities = 57/168 (33%), Positives = 84/168 (50%), Gaps = 5/168 (2%) Frame = +2 Query: 236 DHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQ 400 DH + T + N ++ R QE IK+ +F N Y+G+ H+ + Sbjct: 62 DHNVSTQTKDINACGEMARIQMQEL-------IKNCKEFGVELYDLNHPYQGIVHVMGPE 114 Query: 401 EGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEM 580 +G PG ++ DSHT GAFG A GIG ++ V+ T T++ + G+ Sbjct: 115 QGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKA 174 Query: 581 PPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P + AKD++L IIG+ +G T +EF G I L+ME RMTLCNM Sbjct: 175 APGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNM 222
>LEU2_SHIDS (Q32K22) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 92.0 bits (227), Expect = 2e-18 Identities = 57/168 (33%), Positives = 84/168 (50%), Gaps = 5/168 (2%) Frame = +2 Query: 236 DHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQ 400 DH + T + N ++ R QE IK+ +F N Y+G+ H+ + Sbjct: 62 DHNVSTQTKDINACGEMARIQMQEL-------IKNCKEFGVELYDLNHPYQGIVHVMGPE 114 Query: 401 EGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEM 580 +G PG ++ DSHT GAFG A GIG ++ V+ T T++ + G+ Sbjct: 115 QGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKA 174 Query: 581 PPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P + AKD++L IIG+ +G T +EF G I L+ME RMTLCNM Sbjct: 175 APGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNM 222
>LEU2_SHIBS (Q326G3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 466 Score = 92.0 bits (227), Expect = 2e-18 Identities = 57/168 (33%), Positives = 84/168 (50%), Gaps = 5/168 (2%) Frame = +2 Query: 236 DHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQ 400 DH + T + N ++ R QE IK+ +F N Y+G+ H+ + Sbjct: 62 DHNVSTQTKDINACGEMARIQMQEL-------IKNCKEFGVELYDLNHPYQGIVHVMGPE 114 Query: 401 EGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEM 580 +G PG ++ DSHT GAFG A GIG ++ V+ T T++ + G+ Sbjct: 115 QGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKA 174 Query: 581 PPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P + AKD++L IIG+ +G T +EF G I L+ME RMTLCNM Sbjct: 175 APGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNM 222
>LEU2_PROMA (Q7VDT0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 468 Score = 92.0 bits (227), Expect = 2e-18 Identities = 62/216 (28%), Positives = 96/216 (44%), Gaps = 7/216 (3%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTA------- 256 PG + + V + + H+V P ++ V E+ + DH + T Sbjct: 20 PGGSTQLFVGLHLIHEVTSPQAFSALNEK---GLSVHCPERTIATVDHIVPTTSQNRPFP 76 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 D A + + L C + IK+F + +G+ H+ + G +PG + Sbjct: 77 DSLAEQMLRTLELNCLKHSIKFF---------KIGSGNQGIVHVIAPETGLTQPGMTIAC 127 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG + V+ + +K R DG + + AKDLIL Sbjct: 128 GDSHTSTHGAFGSIAFGIGTSQVRDVLASQTLAMKKLKVKRIWFDGYLQKGVFAKDLILH 187 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +I ++ V + EF G I+ L+MEERMT+CNM Sbjct: 188 VIQKLGVKDGVGYAYEFAGPAIDGLSMEERMTICNM 223
>LEU2_METCA (Q606F2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 470 Score = 92.0 bits (227), Expect = 2e-18 Identities = 56/173 (32%), Positives = 89/173 (51%) Frame = +2 Query: 206 WDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCH 385 W + + + DH + TAD R D + E K D +++F + +G+ H Sbjct: 53 WRVDANLAVADHNVPTAD-RDRGIADPVSRLQVETLDKNCADF-GITEFAMDDVRQGIVH 110 Query: 386 IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFV 565 + ++G PG ++ DSHT GAFG A GIG ++ V+ T + + + Sbjct: 111 VIGPEQGATLPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQCLVQRKAKNMLVR 170 Query: 566 LDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + G++ P + AKDL+L +IG I +G T ++EF G I L+ME RMT+CNM Sbjct: 171 VQGKLAPGVTAKDLVLAVIGRIGTAGGTGYTIEFAGEAIRGLSMEGRMTVCNM 223
>LEU2_SYNY3 (P54384) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 468 Score = 91.3 bits (225), Expect = 3e-18 Identities = 58/215 (26%), Positives = 101/215 (46%), Gaps = 3/215 (1%) Frame = +2 Query: 89 SLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERA 268 S+ P + + + + H+V P + K+ +V E+ V DH + T +++ Sbjct: 17 SVLPSGQTQLFIGLHLIHEVTSPQAFAMLKER---GLRVMYPERTVATVDHIVPTENQQR 73 Query: 269 NRNVDILRDFCQEQKIKYFYDIKDLSDFRANP---DYKGVCHIALAQEGHCRPGEVLLGT 439 + + Q ++ + R +P +G+ H+ ++G +PG + Sbjct: 74 PFQDSLAEEMMQALEVN-----TKAHNIRFHPIGSGNQGIVHVIAPEQGLTQPGMTIACG 128 Query: 440 DSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQI 619 DSHT GAFG A GIG + V+ L + ++G++ P + AKD+IL I Sbjct: 129 DSHTSTHGAFGAIAFGIGTSQVRDVLAAQSLSLNKLKVRKIEVNGDLAPGVYAKDVILHI 188 Query: 620 IGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 I ++ V G + E+ GST ++ MEERMT+CNM Sbjct: 189 IRKLGVKGGVGYAYEYAGSTFVAMNMEERMTVCNM 223
>LYS4_EMENI (Q92412) Homoaconitase, mitochondrial precursor (EC 4.2.1.36)| (Homoaconitate hydratase) Length = 775 Score = 90.9 bits (224), Expect = 4e-18 Identities = 62/242 (25%), Positives = 114/242 (47%), Gaps = 6/242 (2%) Frame = +2 Query: 17 ASTGSVKSPMTTTEKILARAS----ERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQE 184 A S P T TEKI+ + S + ++ G+ V + MTHD P + Sbjct: 57 ALNSSKAVPQTLTEKIVQKYSVGLPQGKFVKSGDYVTIQPHRCMTHDNSWPCALKFMS-- 114 Query: 185 FGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANP 364 G +++ + +++V+ DH + ++ + + +F + ++++ P Sbjct: 115 IGA-SRLHNPDQIVMTLDHDVQNKSDKNLKKYRQIEEFATQHGVEFY------------P 161 Query: 365 DYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKV 544 +G+ H + +EG PG + + +DSH+ G G T I TDA V TGK ++ Sbjct: 162 AGRGIGHQIMIEEGFAWPGTLAVASDSHSNMYGGVGCLGTPIVRTDAASVWATGKTWWQI 221 Query: 545 PPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGS--TIESLTMEERMTLC 718 PP + G +PP + KD+I+ + G + ++EF GS T+ SL+++ R+T+ Sbjct: 222 PPVAKVTFKGVLPPGVTGKDVIVALCGLFNKDDVLNHAIEFTGSEETMRSLSVDTRLTIA 281 Query: 719 NM 724 NM Sbjct: 282 NM 283
>LEU2_PSYAR (Q4FRU7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 472 Score = 90.9 bits (224), Expect = 4e-18 Identities = 51/176 (28%), Positives = 89/176 (50%), Gaps = 3/176 (1%) Frame = +2 Query: 206 WDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIK---DLSDFRANPDYKG 376 W + PDH + T + + V ++D ++ + D+++F N +G Sbjct: 53 WRLSANIASPDHNVPTVTKERSEGVAGIKDKVSRLQVLTLDNNCAKFDIAEFTINDARQG 112 Query: 377 VCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTI 556 + H+ ++G PG ++ DSHT GA G A GIG ++ V+ T + K + Sbjct: 113 ILHVVGPEQGLVLPGMTVVCGDSHTATHGALGCLAHGIGTSEVEHVLATQCLIQKKSKNM 172 Query: 557 RFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + + GE+ + +KD++L II +I +G T ++EF G E ++ME RMT+CNM Sbjct: 173 QIRVTGELGVGVTSKDVVLAIIAKIGTAGGTGHAIEFAGQVFEDMSMEGRMTVCNM 228
>LEU22_PYRFU (Q8U0C0) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 380 Score = 90.1 bits (222), Expect = 6e-18 Identities = 67/229 (29%), Positives = 107/229 (46%), Gaps = 1/229 (0%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 MT E+IL S GE+V VD++ HD P I F + F R + Sbjct: 1 MTLIEEILGGKS-------GESVVRRVDLVYAHDGTMPLIIEAFNKVFATV-----RARA 48 Query: 224 VIIPDH-YIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQ 400 I DH Y + AN +I RDF + +I + +G+ H + + Sbjct: 49 YIFFDHVYPAPTVKIANLQKEI-RDFAKRHRIPVI-------------EGQGISHQLVVE 94 Query: 401 EGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEM 580 G ++++G DSHT GA G FA G+G TD ++G GK ++P ++ +L+G Sbjct: 95 MGLTENSKIVVGADSHTPTLGALGVFAVGMGATDVAVILGLGKTWFRIPESVGVILEGNP 154 Query: 581 PPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNMV 727 Y++A D+IL ++ + YR++EF +++ER+TL N V Sbjct: 155 SRYVMATDVILHLLSLLKDYDMNYRAVEFFN---VPFSLDERLTLTNFV 200
>LEU2_DECAR (Q47HR4) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 468 Score = 90.1 bits (222), Expect = 6e-18 Identities = 65/208 (31%), Positives = 94/208 (45%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNV 280 +D + H+V P K K W +V PDH T D + + V Sbjct: 27 IDRHLIHEVTSPQAFEGLKLA---GRKPWRVSSIVATPDHNTPTDHWEEGIKDPISRQQV 83 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 + L +E ++ KD G+ H+ + G PG ++ DSHT Sbjct: 84 ETLDANIREVGALAYFPFKD--------QRMGILHVVGPENGATLPGMTVVCGDSHTSTH 135 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAF A GIG ++ V+ T L K T+ ++G++ + AKD+ L IIG I + Sbjct: 136 GAFACMAHGIGTSEVEHVLATQCLLQKRSKTMLVAVEGKLGKGVTAKDVALAIIGTIGTA 195 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 G T ++EF GS I L+ME RMTLCNM Sbjct: 196 GGTGYAIEFGGSAIRGLSMEGRMTLCNM 223
>LEU2_BACSK (Q5WEN5) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 470 Score = 89.7 bits (221), Expect = 8e-18 Identities = 68/216 (31%), Positives = 102/216 (47%), Gaps = 6/216 (2%) Frame = +2 Query: 95 EPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTA------ 256 E G+ + VD+ M H+V P F+ V +K DH + T Sbjct: 18 ESGKPNLLYVDLHMVHEVTSPQA---FEGLRLAGRTVRRPDKTFATMDHNVPTVNRYDIR 74 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 D+ A ++ L C++ I ++ DL +P+ G+ H+ + G +PG V++ Sbjct: 75 DQIARTQMETLAANCKQFGI----EMVDLD----HPE-NGIVHVIGPELGLTQPGHVIVC 125 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG ++ V+ T P T+ + G + + AKD+IL Sbjct: 126 GDSHTSTHGAFGAIAFGIGTSEVEHVLATQTIWQSKPKTLEVHISGRLNEGISAKDVILA 185 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 II + V T +EF G I +TMEERMT+CNM Sbjct: 186 IIAKFGVDIGTGSIIEFTGEAIRGMTMEERMTICNM 221
>LEU2_ACIAD (Q6FEW0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 477 Score = 89.4 bits (220), Expect = 1e-17 Identities = 50/176 (28%), Positives = 89/176 (50%), Gaps = 3/176 (1%) Frame = +2 Query: 206 WDREKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYD---IKDLSDFRANPDYKG 376 W + PDH + T+ + + + + D +++ D ++ +F N +G Sbjct: 58 WRLNANIATPDHNVPTSKKEREQGIAGIEDDTSRIQVQTLDDNCKTFNIVEFGINDIRQG 117 Query: 377 VCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTI 556 + H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T + K + Sbjct: 118 IVHVVGPEQGLTLPGMTVVCGDSHTATHGAFGCLAHGIGTSEVEHVLATQCLIQKKSKNM 177 Query: 557 RFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +DG++ + KD++L IIG+I +G T ++EF G +++E RMT+CNM Sbjct: 178 LIRVDGQLGKGVTPKDVVLAIIGKIGTAGGTGYAIEFGGQVFRDMSIEGRMTVCNM 233
>LEU2_THET8 (Q9ZND5) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 472 Score = 89.4 bits (220), Expect = 1e-17 Identities = 72/233 (30%), Positives = 109/233 (46%), Gaps = 7/233 (3%) Frame = +2 Query: 47 TTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVV 226 T EK+ A E L+ G++ + +D+ + H+V P G+ K + G + R Sbjct: 4 TLYEKVW-EAHEVRKLKNGQSQ-LFIDLHLLHEVTSPQAFGMLK-DLGLRVRYPHRTFAT 60 Query: 227 IIPDHYIFTADER-------ANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCH 385 + DH + T D A ++ LR +E I +F DL +G+ H Sbjct: 61 V--DHIVPTHDRTEPFQDPLAQSMLEALRANTREHGITFF----DLGSGN-----QGIVH 109 Query: 386 IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFV 565 + Q G +PG + DSHT GAFG A GIG + V+ T + R Sbjct: 110 VIGPQLGLTQPGMTIACGDSHTSTHGAFGAVAFGIGTSQVRDVLATQTLAAQKLKVRRIN 169 Query: 566 LDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++G + P + AKD+IL II + V G + E+ GS +E++ ME RMTLCNM Sbjct: 170 VEGRLAPGVYAKDVILHIIRHLGVKGGLGYAYEYGGSAVEAMDMESRMTLCNM 222
>LEU2_THET2 (Q72JB3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 472 Score = 89.4 bits (220), Expect = 1e-17 Identities = 72/233 (30%), Positives = 109/233 (46%), Gaps = 7/233 (3%) Frame = +2 Query: 47 TTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVV 226 T EK+ A E L+ G++ + +D+ + H+V P G+ K + G + R Sbjct: 4 TLYEKVW-EAHEVRKLKNGQSQ-LFIDLHLLHEVTSPQAFGMLK-DLGLRVRYPHRTFAT 60 Query: 227 IIPDHYIFTADER-------ANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCH 385 + DH + T D A ++ LR +E I +F DL +G+ H Sbjct: 61 V--DHIVPTHDRTEPFQDPLAQSMLEALRANTREHGITFF----DLGSGN-----QGIVH 109 Query: 386 IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFV 565 + Q G +PG + DSHT GAFG A GIG + V+ T + R Sbjct: 110 VIGPQLGLTQPGMTIACGDSHTSTHGAFGAVAFGIGTSQVRDVLATQTLAAQKLKVRRIN 169 Query: 566 LDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++G + P + AKD+IL II + V G + E+ GS +E++ ME RMTLCNM Sbjct: 170 VEGRLAPGVYAKDVILHIIRHLGVKGGLGYAYEYGGSAVEAMDMESRMTLCNM 222
>LEU2_CHRVO (Q7NUB6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 471 Score = 89.0 bits (219), Expect = 1e-17 Identities = 66/208 (31%), Positives = 97/208 (46%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNV 280 +D + H+V P K ++W + VV DH T D + + V Sbjct: 28 IDRHLVHEVTSPQAFEGLKLA---GRRLWRVDSVVSTADHNTPTDHWDQGIQDPISRQQV 84 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 + L + IK F L+ F +G+ H+ ++G PG ++ DSHT Sbjct: 85 ETL-----DANIKAF---GALAYFPFKDKGQGIVHVMGPEQGATLPGMTVVCGDSHTSTH 136 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ VM T + K + +DG + + AKD+ L IIG+I + Sbjct: 137 GAFGALAHGIGTSEVEHVMATQCLVAKKSKNMLVRVDGRLGAGITAKDVALAIIGKIGTA 196 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 G T ++EF G I L+ME RMTLCNM Sbjct: 197 GGTGYAIEFGGEAIRGLSMEGRMTLCNM 224
>LEU2_BUCRP (P48573) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 471 Score = 89.0 bits (219), Expect = 1e-17 Identities = 56/201 (27%), Positives = 102/201 (50%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D+ + H+V P + + + V +K DH + T + N + + + Sbjct: 27 IDLHLLHEVTSPQAFDSLRIK---NRVVRQPKKTFATMDHNVSTESKDINASGSMAK--I 81 Query: 302 QEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFA 481 Q Q++ + ++S + N +G+ H+ ++G PG ++ DSHT GAFG + Sbjct: 82 QMQQLIRNCNQFNISLYDLNNPKQGIVHVIGPEQGMTLPGMTIVCGDSHTSTHGAFGALS 141 Query: 482 TGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSM 661 GIG ++ V+ T + ++ + G++ ++ AKD+IL IIG++ SG + + Sbjct: 142 FGIGTSEVEHVLVTQTLKQQRLKNMKIQIKGKIKNFVTAKDIILFIIGKLGTSGGSGYVI 201 Query: 662 EFVGSTIESLTMEERMTLCNM 724 EF G I+ + MEERMT+CNM Sbjct: 202 EFCGDVIKKMNMEERMTVCNM 222
>LEU22_PYRAB (Q9V1J0) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 380 Score = 89.0 bits (219), Expect = 1e-17 Identities = 65/210 (30%), Positives = 100/210 (47%), Gaps = 1/210 (0%) Frame = +2 Query: 95 EPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDH-YIFTADERAN 271 +PGE V VD++ HD P I F + F E R + I DH Y + AN Sbjct: 11 KPGEAVIRKVDLVYAHDGTMPLIIEAFNRIFNEV-----RTRAYIFFDHVYPAPTVKVAN 65 Query: 272 RNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHT 451 + +I R+F + I + KG+ H + + G ++++G DSHT Sbjct: 66 LHREI-REFAKIHGIPVV-------------EGKGISHQLVVELGLAEEAKIIVGGDSHT 111 Query: 452 CNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEI 631 GA G FA G+G TD +G GK LKVP +I +LDG Y++A D+++ +I + Sbjct: 112 PTLGALGVFAVGMGATDVAIALGLGKIWLKVPESIAVLLDGSPREYIMASDVMIHLITSL 171 Query: 632 SVSGATYRSMEFVGSTIESLTMEERMTLCN 721 +Y ++EF + +ER+TL N Sbjct: 172 KDREMSYNAIEFFN---VPFSFDERLTLTN 198
>LEU2_CORDI (Q6NHL0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 480 Score = 89.0 bits (219), Expect = 1e-17 Identities = 57/150 (38%), Positives = 76/150 (50%), Gaps = 1/150 (0%) Frame = +2 Query: 278 VDILRDFCQEQKIKYFYDIKDLSDFRANPDYK-GVCHIALAQEGHCRPGEVLLGTDSHTC 454 V+ LR C+E ++ A D K G+ H Q G +PG ++ DSHT Sbjct: 97 VETLRKNCEEFGVR----------LHAMGDKKQGIVHQVGPQLGATQPGMTIVCGDSHTS 146 Query: 455 NAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEIS 634 GAFG A GIG ++ VM T LK T+ + GE+ P + AKDLIL +I I Sbjct: 147 THGAFGAMAFGIGTSEVEHVMATQTLSLKPFKTMAINVTGELQPGVTAKDLILAVIATIG 206 Query: 635 VSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G +E+ G IE L+ME RMT+CNM Sbjct: 207 TGGGQGHVIEYRGEAIEKLSMEARMTVCNM 236
>LEU22_MANSM (Q65V07) 3-isopropylmalate dehydratase large subunit 2 (EC| 4.2.1.33) (Isopropylmalate isomerase 2) (Alpha-IPM isomerase 2) (IPMI 2) Length = 469 Score = 88.6 bits (218), Expect = 2e-17 Identities = 46/128 (35%), Positives = 73/128 (57%) Frame = +2 Query: 341 LSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMG 520 +S F N +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ Sbjct: 95 ISLFDMNTKEQGIVHVMGPEQGLTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLA 154 Query: 521 TGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTME 700 T +++ + G++ P + AKD++L IIG+ +++G T +EF G I L+ME Sbjct: 155 TQTLKQARAKSMKVEVRGKVNPGITAKDIVLAIIGKTTMAGGTGHVVEFCGEAIRDLSME 214 Query: 701 ERMTLCNM 724 RMT+CNM Sbjct: 215 GRMTVCNM 222
>LEU2_LEIXX (Q6AFK7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 486 Score = 88.6 bits (218), Expect = 2e-17 Identities = 54/157 (34%), Positives = 82/157 (52%) Frame = +2 Query: 254 ADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLL 433 AD + ++ LR +E ++ + L D +G+ H+ Q G PG ++ Sbjct: 81 ADLTSRTQIETLRRNAEEFGVR----LHSLGDIE-----QGIVHVVGPQLGLTMPGITVV 131 Query: 434 GTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLIL 613 DSHT GAFG A GIG ++ V+ T LK T+ ++GE+ P + AKD+IL Sbjct: 132 CGDSHTSTHGAFGAMAFGIGTSEVEHVLATQTLPLKPFKTMGITVEGELRPGVTAKDIIL 191 Query: 614 QIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +I +I G +E+ GS I +L+ME RMT+CNM Sbjct: 192 AVIAKIGTGGGQGYVLEYRGSAIRALSMEGRMTVCNM 228
>LEU2_SHEON (Q8E9N4) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 474 Score = 88.6 bits (218), Expect = 2e-17 Identities = 68/215 (31%), Positives = 101/215 (46%), Gaps = 7/215 (3%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER----- 265 GE + VD + H+V P K G + EK DH T Sbjct: 28 GEAPIIYVDRHLVHEVTSPQAFSGLKVA-GRQLRA--PEKTFATMDHNTSTRSASLDALS 84 Query: 266 --ANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGT 439 A V+ L C++ + YDI +P+ +G+ H+ + G PG V++ Sbjct: 85 PMARIQVETLAQNCKDFGV-LLYDIH-------HPN-QGIVHVMGPELGITLPGTVIVCG 135 Query: 440 DSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQI 619 DSHT GAFG A GIG ++ V+ T T++ + G++ + AKD++L I Sbjct: 136 DSHTATHGAFGALAFGIGTSEVEHVLATQTLRQLKAKTMKIEVRGQVTDGVTAKDIVLAI 195 Query: 620 IGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 IG+I + G T +EF G IE+L+ME RMT+CNM Sbjct: 196 IGKIGMDGGTGYVVEFCGEAIEALSMEGRMTVCNM 230
>LEU2_BUCAP (O85065) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 87.8 bits (216), Expect = 3e-17 Identities = 54/201 (26%), Positives = 100/201 (49%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D+ + H+V P + + V +K DH + T + N + + + Sbjct: 27 IDLHLLHEVTSPQAFDSLRMR---NRSVRQPKKTFATMDHNVSTESKDINASGSMAK--I 81 Query: 302 QEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFA 481 Q Q++ + +++ + N +G+ H+ ++G PG ++ DSHT GAFG + Sbjct: 82 QMQQLIKNCEEFNIALYDLNNPKQGIVHVIGPEQGLTLPGSTIVCGDSHTSTHGAFGALS 141 Query: 482 TGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSM 661 GIG ++ V+ T + ++ + G++ ++ AKD+IL IIG++ S + + Sbjct: 142 FGIGTSEVEHVLVTQTLKQQRFKNMKIKIVGKVKKFITAKDIILFIIGKLGTSSGSGYVI 201 Query: 662 EFVGSTIESLTMEERMTLCNM 724 EF G I+ + MEERMT+CNM Sbjct: 202 EFCGDVIKKMNMEERMTICNM 222
>LEU2_SYNPX (Q7U9J4) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 472 Score = 87.0 bits (214), Expect = 5e-17 Identities = 63/216 (29%), Positives = 96/216 (44%), Gaps = 7/216 (3%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------A 256 PG + + V + + H+V P + + V E+ V DH + T A Sbjct: 20 PGGSTQLFVGLHLIHEVTSPQAFAALRDK---GLSVRCPERTVATVDHIVPTTSQSRPFA 76 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 D A + L C + I + + R +G+ H+ + G +PG + Sbjct: 77 DSLAEEMLSTLERNCADHGIT----LNGIGSGR-----QGIVHVIAPELGLTQPGMTVAC 127 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG + V+ + + R ++G + + AKDLIL Sbjct: 128 GDSHTSTHGAFGAIAFGIGTSQVRDVLASQSLAMSKLKVRRIQVNGRLSDGVSAKDLILH 187 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +I + V G + EF G +E+L+MEERMTLCNM Sbjct: 188 VIRTLGVKGGVGFAYEFAGPAVEALSMEERMTLCNM 223
>LEU2_BUCBP (P59519) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 471 Score = 86.7 bits (213), Expect = 7e-17 Identities = 61/208 (29%), Positives = 98/208 (47%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER-------ANRNV 280 +D+ + H+V P F ++ V +K DH + T D A + + Sbjct: 27 IDLHLVHEVTSPQA---FFSLCSKNRVVRQPKKTFATMDHNVSTIDRNIDSSGLLAKKQM 83 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 + L C + IK F DL N ++G+ H+ ++G PG ++ DSHT Sbjct: 84 EALIKNCTKFNIKLF----DL-----NHPHQGIVHVIGPEQGITLPGMTIVCGDSHTSTH 134 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ V+ T ++ ++G++ + AKD+IL +I ++ VS Sbjct: 135 GAFGALAFGIGTSEVEHVLATQTLKQNRLKSMHIKINGDIDIGITAKDIILFVIKQLGVS 194 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 +EF G + L+ME RMTLCNM Sbjct: 195 RGLGYVIEFSGEIVSKLSMESRMTLCNM 222
>LEU2_RHINI (P55811) 3-isopropylmalate dehydratase (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 750 Score = 86.7 bits (213), Expect = 7e-17 Identities = 46/128 (35%), Positives = 70/128 (54%) Frame = +2 Query: 341 LSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMG 520 L+ F +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ Sbjct: 101 LTYFGMEDSRQGIVHVIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLA 160 Query: 521 TGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTME 700 T L K +R ++G+ + +KD+ L +IG I +G T +EF G ESL+ME Sbjct: 161 TQTLLQKKSKNMRIRVEGKPSAGVTSKDIALHVIGVIGTAGGTGCVIEFCGEANESLSME 220 Query: 701 ERMTLCNM 724 RM++CNM Sbjct: 221 SRMSICNM 228
>LEU2_HALMA (Q5V518) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 473 Score = 86.3 bits (212), Expect = 9e-17 Identities = 59/203 (29%), Positives = 99/203 (48%), Gaps = 2/203 (0%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 V + + H+V P G+ K+ E A+ V DH + TA++ + D Sbjct: 28 VGLHLIHEVTSPQAFGMIKERGLEVARPDLTHATV---DHIVPTANQDRPYSDDAAETMM 84 Query: 302 QEQKIKYFYDIKDLSDFRANPDY--KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQ 475 E + +++D ++P +G+ H+ ++G +PG+ ++ DSHT GAFG Sbjct: 85 AELE----ENVRDAGIQFSDPTTGDQGIVHVIGPEQGITQPGKTIVCGDSHTSTHGAFGA 140 Query: 476 FATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYR 655 A GIG + V+ T ++ + + GE+ + AKD+IL+II + G Sbjct: 141 LAFGIGTSQIRDVLATQTIAMEKQKVRKIEVTGELDEGVEAKDIILEIIRRLGTEGGVGY 200 Query: 656 SMEFVGSTIESLTMEERMTLCNM 724 E+ G TIE+L ME RM++CNM Sbjct: 201 VYEYAGETIENLDMEGRMSICNM 223
>LEU2_THEFY (Q47SA3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 465 Score = 86.3 bits (212), Expect = 9e-17 Identities = 63/215 (29%), Positives = 102/215 (47%), Gaps = 7/215 (3%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------AD 259 GE + +D+ + H+V P F+ + K+ + + DH + T AD Sbjct: 20 GEPDLLYIDLHLIHEVTSPQA---FEGLRLANRKLRRPDLTIATEDHNVPTENIFLPIAD 76 Query: 260 ERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGT 439 + V+ LR E ++ + + D+ +G+ H+ Q G +PG ++ Sbjct: 77 PVSRTQVETLRKNAAEFGVR-LHPMGDID--------QGIVHVIGPQLGLTQPGMTIVCG 127 Query: 440 DSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQI 619 DSHT GAFG A GIG + VM T + T+ ++G++ P + AKD+IL + Sbjct: 128 DSHTSTHGAFGALAFGIGTSQVEHVMATQTLPMTPFKTMAVNVEGKLKPGVTAKDIILAV 187 Query: 620 IGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 I +I G +E+ G I SL+ME RMT+CNM Sbjct: 188 IAQIGTGGGQGHVIEYRGEAIRSLSMEARMTICNM 222
>LEU2_ACTTI (Q44427) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 485 Score = 86.3 bits (212), Expect = 9e-17 Identities = 53/157 (33%), Positives = 78/157 (49%) Frame = +2 Query: 254 ADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLL 433 AD + ++ LR C E + +I+ L D +G+ H+ Q G +PG ++ Sbjct: 95 ADTVSRTQIETLRKNCAE----FGVEIRPLGDVN-----QGIVHVIGPQLGLTQPGMTIV 145 Query: 434 GTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLIL 613 DSHT GA G A GIG ++ V+ T P T+ + GE+ P + AKDLIL Sbjct: 146 CGDSHTATHGASGALAFGIGTSEVEHVLATQTLPQSKPKTMAVTVVGELRPGVSAKDLIL 205 Query: 614 QIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +I + G +E+ G I L+ME RMT+CNM Sbjct: 206 TLITQTGTGGGNGHIVEYRGEAIRKLSMEGRMTICNM 242
>LEU2_AZOSE (Q5P1J8) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 85.9 bits (211), Expect = 1e-16 Identities = 63/208 (30%), Positives = 95/208 (45%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------ADERANRNV 280 +D + H+V P K K W +V DH T D + + V Sbjct: 28 IDRHLIHEVTSPQAFEGLKLA---GRKPWRVSSIVATADHNTPTDHWERGILDPVSRQQV 84 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 + L +E ++ +D +G+ H+ + G PG ++ DSHT Sbjct: 85 ETLDANIREVGALAYFPFRDAR--------QGIVHVIGPEIGATLPGMTVVCGDSHTSTH 136 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAF A GIG ++ V+ T L K T+ +DGE+ + AKD+ L IIG + + Sbjct: 137 GAFACLAHGIGTSEVEHVLATQCLLQKRSKTMLVRVDGELGRGVSAKDIALAIIGRLGTA 196 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 G T ++EF GS I +L+ME RMT+CNM Sbjct: 197 GGTGYAIEFGGSAIRALSMEGRMTICNM 224
>LEU2_HALVO (Q7ZAG7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 473 Score = 85.9 bits (211), Expect = 1e-16 Identities = 57/200 (28%), Positives = 98/200 (49%), Gaps = 3/200 (1%) Frame = +2 Query: 134 MTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADE-RANRNVDILRDFCQEQ 310 + H+V P G+ ++ D +V + DH + T+D+ R R+ D +E Sbjct: 32 LIHEVTSPQAFGMLQER---DLEVAYPNRTHATVDHIVPTSDQSRPFRD-----DAAEEM 83 Query: 311 KIKYFYDIKDLSDFRANPDY--KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFAT 484 + ++++ ++P +G+ H+ ++G +PG ++ DSHT GAFG A Sbjct: 84 MAELEQNVREAGINFSDPTSGEQGIVHVIGPEKGLTQPGMTIVCGDSHTSTHGAFGALAF 143 Query: 485 GIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSME 664 GIG + V+ T ++ + + GE+ P + AKD+IL+II + G E Sbjct: 144 GIGTSQIRDVLATQTVAMEKKKVRKIEVTGELGPGVEAKDVILEIIRRLGTEGGVGYVYE 203 Query: 665 FVGSTIESLTMEERMTLCNM 724 + G IE L ME RM++CNM Sbjct: 204 YAGEAIEDLDMEGRMSICNM 223
>LEU2_NATPD (Q3IRQ4) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 474 Score = 85.5 bits (210), Expect = 2e-16 Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 2/203 (0%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 V + + H+V P G+ ++ D +V + DH + TAD+ +R +D + Sbjct: 28 VGLHLIHEVTSPQAFGMLRER---DIEVARPDLTHATVDHIVPTADQ--SRPLD--NEAA 80 Query: 302 QEQKIKYFYDIKDLSDFRANPDY--KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQ 475 +E + ++++ +P +G+ H+ ++G +PG+ ++ DSHT GAFG Sbjct: 81 EEMMAELEENVREAGITLDDPTTGNQGIVHVIGPEQGLTQPGKTIVCGDSHTSTHGAFGA 140 Query: 476 FATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYR 655 A GIG + V+ T ++ + + GE+ + AKD+IL II + G Sbjct: 141 LAFGIGTSQIRDVLATQTIAMEKKDVRKIEVTGELGEGVTAKDIILTIIRRLGTDGGVGY 200 Query: 656 SMEFVGSTIESLTMEERMTLCNM 724 E+ G IE+L ME RM++CNM Sbjct: 201 VYEYAGEAIENLGMEGRMSICNM 223
>LEU2_BIFLO (Q8G4W2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 467 Score = 85.5 bits (210), Expect = 2e-16 Identities = 62/208 (29%), Positives = 98/208 (47%), Gaps = 7/208 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTAD-------ERANRNV 280 +D+++ H+V P + + V ++++ DH T D E + + Sbjct: 28 IDLMLMHEVTSPQAFEGLRLAGRKPRHV---DQLIATEDHNTPTVDIDRPNPDETSALQL 84 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNA 460 L C+E ++ + L D +G+ H G +PG ++ DSHT Sbjct: 85 TTLEKNCKEFGVR----LHPLGDAD-----QGIVHAFAPILGLTQPGMTIVCGDSHTSTH 135 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 GAFG A GIG ++ VM T LK T+ ++G++P AKD+IL II +I Sbjct: 136 GAFGALAFGIGTSEVEHVMATQTLSLKPFKTMAVNVNGKLPADATAKDIILAIIAKIGTG 195 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 G +E+ G I +LTM+ERMT+CNM Sbjct: 196 GGQGYVIEYRGEAIRNLTMDERMTVCNM 223
>ACON_SCHPO (O13966) Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3)| (Citrate hydro-lyase) (Aconitase) Length = 778 Score = 85.1 bits (209), Expect = 2e-16 Identities = 56/155 (36%), Positives = 79/155 (50%) Frame = +2 Query: 260 ERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGT 439 ERAN + DF Q KY ++ +R G+ H + E + PG +L+GT Sbjct: 137 ERANVTNKEVYDFLQTACAKY-----NIGFWRPG---SGIIH-QIVLENYAFPGGLLIGT 187 Query: 440 DSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQI 619 DSHT NAG G A G+G DA VM LK P I L G++ + KD+IL++ Sbjct: 188 DSHTPNAGGLGMVAIGVGGADAVDVMANLPWELKCPKVIGVKLTGQLKGWTSPKDVILKV 247 Query: 620 IGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 G ++V G T +E+ G +ESL+ T+CNM Sbjct: 248 AGILTVKGGTGAIVEYFGPGVESLSCTGMGTICNM 282
>LEU2_SYNEL (Q8DKF0) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 84.7 bits (208), Expect = 3e-16 Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 7/216 (3%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFT-------A 256 P + + + + H+V P + ++ V ++ + DH + T Sbjct: 22 PSGQTQLFIGLHLIHEVTSPQAFAMLRER---GLPVLYPQRTIATVDHIVPTDTLARPLQ 78 Query: 257 DERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 D A + L C+ I +F +G+ H+ ++G +PG + Sbjct: 79 DALAEEMLQALEANCRAHNIPFF---------GIGSGRQGIVHVIAPEQGLTQPGMTIAC 129 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG + V+ T L + ++G + + AKD+IL Sbjct: 130 GDSHTSTHGAFGAIAFGIGTSQVRDVLATQTLALNKLKVRKVEVNGSLAAGVYAKDVILH 189 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +I + V G + EF G+T L+MEERMT+CNM Sbjct: 190 VIRHLGVKGGVGYAYEFAGTTFGQLSMEERMTVCNM 225
>LEU2_PROMT (Q46HB8) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 84.7 bits (208), Expect = 3e-16 Identities = 64/216 (29%), Positives = 97/216 (44%), Gaps = 7/216 (3%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER---- 265 PG + + + + + H+V P ++ V V DH + T++++ Sbjct: 20 PGGSTQLFIGLHLIHEVTSPQAFSALNEK---KLGVKFPNLTVATVDHIVPTSNQQRPFS 76 Query: 266 ---ANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLG 436 A + L C+ IK F+ I S +GV H+ + G +PG + Sbjct: 77 DPLAEEMLATLEKNCKTHGIK-FHGIGSNS--------QGVVHVMAPELGLTQPGMTVAC 127 Query: 437 TDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQ 616 DSHT GAFG A GIG + V+ + + R ++GE+ + AKDLIL Sbjct: 128 GDSHTSTHGAFGAIAFGIGTSQVRDVLASQSLAMNKLKVRRIWVEGELQKGVYAKDLILH 187 Query: 617 IIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 II + V G + EF G IE L+ME RMT+CNM Sbjct: 188 IIRHLGVKGGVGFAYEFAGPAIEKLSMEGRMTICNM 223
>LEU2_HAEIN (P44968) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 468 Score = 84.7 bits (208), Expect = 3e-16 Identities = 43/118 (36%), Positives = 69/118 (58%) Frame = +2 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T Sbjct: 104 QGIVHVMGPEQGLTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQARAK 163 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +++ + G++ + AKD+IL IIG+ +++G T +EF G I+ L+ME RMT+CNM Sbjct: 164 SMKIEVRGKVASGITAKDIILAIIGKTTMAGGTGHVVEFCGEAIQDLSMEGRMTVCNM 221
>LEU2_STRGN (Q9AIM3) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Fragment) Length = 456 Score = 84.3 bits (207), Expect = 3e-16 Identities = 51/153 (33%), Positives = 76/153 (49%), Gaps = 3/153 (1%) Frame = +2 Query: 275 NVDILRDFCQEQKI-KYFYDIKDLSDFRA--NPDYKGVCHIALAQEGHCRPGEVLLGTDS 445 N+ +RD + +I K ++KD A + +G+ H+ + G +PG+ ++ DS Sbjct: 66 NIYDIRDVISKAQIDKLSENVKDFGIEHAAHGSELQGIVHMVGPETGKTQPGKFIVCGDS 125 Query: 446 HTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIG 625 HT GAFG A GIG ++ V T P + G P + +KD IL +I Sbjct: 126 HTATHGAFGAIAFGIGTSEVEHVFATQTIWQVKPKKMLVKFTGVPPKGVYSKDFILALIA 185 Query: 626 EISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 V+ +E+ G IE LTMEERMT+CNM Sbjct: 186 RYGVAAGVGHVVEYAGDAIEHLTMEERMTICNM 218
>LEU2_HAEI8 (Q4QLS2) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 469 Score = 84.0 bits (206), Expect = 4e-16 Identities = 43/118 (36%), Positives = 68/118 (57%) Frame = +2 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T Sbjct: 105 QGIVHVMGPEQGLTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQARAK 164 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +++ + G++ + AKD+IL IIG+ +++G T +EF G I L+ME RMT+CNM Sbjct: 165 SMKIEVRGKVASGITAKDIILAIIGKTTMAGGTGHVVEFCGEAIRDLSMEGRMTVCNM 222
>LEU2_PROMM (Q7V4U5) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 478 Score = 83.2 bits (204), Expect = 8e-16 Identities = 60/212 (28%), Positives = 95/212 (44%), Gaps = 3/212 (1%) Frame = +2 Query: 98 PGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADER---A 268 PG + + V + + H+V P + + V E+ V DH + T ++ A Sbjct: 20 PGGSTQLFVGLHLIHEVTSPQAFAALQDK---GLPVRCPERTVATVDHIVPTISQKRPFA 76 Query: 269 NRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQEGHCRPGEVLLGTDSH 448 + + + + Y + L R +G+ H+ + G +PG + DSH Sbjct: 77 DPLAEEMLSTLERNCANYGIVLCGLGSGR-----QGIVHVIAPELGLTQPGMTVACGDSH 131 Query: 449 TCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGE 628 T GAFG A GIG + V+ + + R +DG++ + AKDLIL +I Sbjct: 132 TSTHGAFGAIAFGIGTSQVRDVLASQSLAMNKLKVRRIWVDGQLGSGVYAKDLILHVIRS 191 Query: 629 ISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + V + EF G I+ L+MEERMTLCNM Sbjct: 192 LGVKAGVGYAYEFAGPAIDVLSMEERMTLCNM 223
>ACON_YEAST (P19414) Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3)| (Citrate hydro-lyase) (Aconitase) Length = 778 Score = 82.4 bits (202), Expect = 1e-15 Identities = 51/151 (33%), Positives = 79/151 (52%), Gaps = 11/151 (7%) Frame = +2 Query: 305 EQKIKYFYDI-KDLSDFRANPDYK----------GVCHIALAQEGHCRPGEVLLGTDSHT 451 E+ +K D+ K++ DF A+ K G+ H + E + PG +++GTDSHT Sbjct: 133 EKDLKRAIDLNKEVYDFLASATAKYNMGFWKPGSGIIH-QIVLENYAFPGALIIGTDSHT 191 Query: 452 CNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEI 631 NAG GQ A G+G DA VM LK P + L G+M + KD+IL++ G Sbjct: 192 PNAGGLGQLAIGVGGADAVDVMAGRPWELKAPKILGVKLTGKMNGWTSPKDIILKLAGIT 251 Query: 632 SVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +V G T + +E+ G +++ + T+CNM Sbjct: 252 TVKGGTGKIVEYFGDGVDTFSATGMGTICNM 282
>LEU2_LACLA (Q02142) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 460 Score = 82.4 bits (202), Expect = 1e-15 Identities = 56/213 (26%), Positives = 99/213 (46%), Gaps = 5/213 (2%) Frame = +2 Query: 101 GENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNV 280 GE + +D+ + H+V P ++ +V ++ DH + T D + Sbjct: 21 GEPQLLYIDLHVIHEVTSPQAFQGLREA---GRRVRRKDLTYGTLDHNVPTQD------I 71 Query: 281 DILRDFCQEQKIKYFYDIKDLSDFRANPDY-----KGVCHIALAQEGHCRPGEVLLGTDS 445 ++D +++I F K++ +F + +G+ H+ + G +PG+ ++ DS Sbjct: 72 FNIQDLISKKQIDTF--TKNVKEFDVPAETHGGKGQGIVHMVAPESGRTQPGKTIVCGDS 129 Query: 446 HTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIG 625 HT GAFG A GIG ++ V+ T P ++ G + +KD IL +I Sbjct: 130 HTATNGAFGAIAFGIGTSEVEHVLATQTIWQVKPKRMKIEFQGHPQKGIYSKDFILALIA 189 Query: 626 EISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + V ++E+ G I L+MEERMT+CNM Sbjct: 190 KYGVDAGVGYAVEYSGDAISDLSMEERMTICNM 222
>LEU2_PASMU (Q9CJN7) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 467 Score = 81.6 bits (200), Expect = 2e-15 Identities = 42/118 (35%), Positives = 66/118 (55%) Frame = +2 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ ++G PG ++ DSHT GAFG A GIG ++ V+ T Sbjct: 104 QGIVHVMGPEQGLTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTIKQARAK 163 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ + G++ + AKD++L IIG+ ++ G T +EF G I L+ME RMT+CNM Sbjct: 164 KMKIEVRGKVRDGISAKDIVLAIIGKTTMGGGTGHVVEFCGEAIRDLSMEGRMTVCNM 221
>LEU2_CAMJE (Q9PLW1) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 470 Score = 80.5 bits (197), Expect = 5e-15 Identities = 45/118 (38%), Positives = 62/118 (52%) Frame = +2 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ HI + G PG L+ DSHT GAFG A GIG ++ VM T Sbjct: 107 QGIVHIVGPELGFTLPGVTLVCGDSHTATHGAFGALAFGIGTSEVEHVMATQTLKQAKLK 166 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 T++ G+ + KDLIL +I + + T ++EF G I +L+ME RMTLCNM Sbjct: 167 TMKIECKGQFQKGVYTKDLILYLIAQYGTAKGTGYAIEFCGELIRNLSMEARMTLCNM 224
>LEU2_PYRHO (O59391) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 380 Score = 80.5 bits (197), Expect = 5e-15 Identities = 63/227 (27%), Positives = 103/227 (45%), Gaps = 1/227 (0%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 MT E+IL + GE V +VD++ HD P I F + F + + Sbjct: 1 MTLVEEIL-------DAKAGEVVIRNVDLVYAHDGTMPLIIEAFNKVFNSV-----KARA 48 Query: 224 VIIPDH-YIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQ 400 + DH Y + AN +I R+F + I + KG+ H + + Sbjct: 49 YVFFDHVYPAPTVKVANLQKEI-REFARRHGIPVV-------------EGKGISHQLVVE 94 Query: 401 EGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEM 580 G +++G DSHT GA G FA G+G TD V+G GK L+VP ++ + +G+ Sbjct: 95 MGLAEKSRIVVGGDSHTPTLGALGVFAVGMGATDVAVVLGLGKTWLRVPESVAVIFEGKP 154 Query: 581 PPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCN 721 +A D+++++I + Y+++EF T +ER+TL N Sbjct: 155 SRTTMAADVMIRLITSLRNYDMNYKALEFFN---VPFTADERLTLTN 198
>LEU2_CAMJR (Q5HS78) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 468 Score = 80.5 bits (197), Expect = 5e-15 Identities = 45/118 (38%), Positives = 62/118 (52%) Frame = +2 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ HI + G PG L+ DSHT GAFG A GIG ++ VM T Sbjct: 105 QGIVHIVGPELGFTLPGVTLVCGDSHTATHGAFGALAFGIGTSEVEHVMATQTLKQAKLK 164 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 T++ G+ + KDLIL +I + + T ++EF G I +L+ME RMTLCNM Sbjct: 165 TMKIECKGQFQKGVYTKDLILYLIAQYGTAKGTGYAIEFCGELIRNLSMEARMTLCNM 222
>LYS4_YEAST (P49367) Homoaconitase, mitochondrial precursor (EC 4.2.1.36)| (Homoaconitate hydratase) Length = 693 Score = 79.3 bits (194), Expect = 1e-14 Identities = 55/228 (24%), Positives = 103/228 (45%), Gaps = 4/228 (1%) Frame = +2 Query: 53 TEKIL----ARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREK 220 TEKI+ E + G+ V + M+HD P + + G K+ + + Sbjct: 24 TEKIVQSYAVNLPEGKVVHSGDYVSIKPAHCMSHDNSWP--VALKFMGLGA-TKIKNPSQ 80 Query: 221 VVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALAQ 400 +V DH I E+ + +F ++ I ++ P +G+ H + + Sbjct: 81 IVTTLDHDIQNKSEKNLTKYKNIENFAKKHHIDHY------------PAGRGIGHQIMIE 128 Query: 401 EGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEM 580 EG+ P + + +DSH+ G G T I TDA + TG+ ++PP + L G++ Sbjct: 129 EGYAFPLNMTVASDSHSNTYGGLGSLGTPIVRTDAAAIWATGQTWWQIPPVAQVELKGQL 188 Query: 581 PPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P + KD+I+ + G + ++EF G ++ +L ++ R+T+ NM Sbjct: 189 PQGVSGKDIIVALCGLFNNDQVLNHAIEFTGDSLNALPIDHRLTIANM 236
>ACON_GRAVE (P49609) Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3)| (Citrate hydro-lyase) (Aconitase) Length = 779 Score = 79.3 bits (194), Expect = 1e-14 Identities = 49/140 (35%), Positives = 73/140 (52%), Gaps = 10/140 (7%) Frame = +2 Query: 335 KDLSDFRANPDYK----------GVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFAT 484 K++ DF A+ K G+ H + E + PG +++GTDSHT NAG G A Sbjct: 146 KEVYDFLASAGAKYGLGFWKPGSGIIH-QIVLENYAFPGLLMIGTDSHTPNAGGLGACAV 204 Query: 485 GIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSME 664 G+G DA VM LK P I L G++ + KD+IL++ G ++V G T +E Sbjct: 205 GVGGADAVDVMVGLPWELKAPKVIGVKLTGKLQEWASPKDVILKVAGILTVKGGTGAIVE 264 Query: 665 FVGSTIESLTMEERMTLCNM 724 + G ++SL+ T+CNM Sbjct: 265 YFGEGVDSLSCTGMGTICNM 284
>LEU2_PYRKO (Q5JFV6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 380 Score = 79.3 bits (194), Expect = 1e-14 Identities = 69/228 (30%), Positives = 103/228 (45%), Gaps = 2/228 (0%) Frame = +2 Query: 44 MTTTEKILARASERASLEPGENVWVDVDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKV 223 MT E++L + GE V +VD++ HD P I F++ F +V R V Sbjct: 1 MTLVEELLGAKT-------GEVVVREVDLVYAHDGTMPLIIEAFRRNF---TRVVPRTYV 50 Query: 224 VIIPDHYIFTAD--ERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIALA 397 DH +F A + AN +IL +F EQ I +G+ H Sbjct: 51 FF--DH-VFPAPTVKIANLQKEIL-EFAGEQGIPVIQG-------------QGISHQLAV 93 Query: 398 QEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGE 577 + G +++G DSHT GA G FA GIG TD VMG GK +VP ++ V +G Sbjct: 94 EMGLADNARIVVGADSHTPTLGALGVFAVGIGATDTAVVMGLGKTWFRVPESVSVVFEGR 153 Query: 578 MPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCN 721 ++A D ++ II + Y+++EF + +ER+TL N Sbjct: 154 PGKNVMAADAMIHIITALRDFEMNYKAIEFFN---VPFSFDERLTLTN 198
>LEU2_STRT1 (Q5LZF4) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 460 Score = 78.2 bits (191), Expect = 2e-14 Identities = 42/120 (35%), Positives = 63/120 (52%) Frame = +2 Query: 365 DYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKV 544 D +G+ H+ + G +PG+ ++ DSHT GAFG A GIG ++ V T Sbjct: 103 DKQGIVHMVGPETGRTQPGKFIVCGDSHTATHGAFGAIAFGIGTSEVEHVFATQTLWQVK 162 Query: 545 PPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P + G+ + +KD IL +I + V+ +E+ G I+ LTMEERMT+CNM Sbjct: 163 PKKMLLEFTGKPQKGIYSKDYILALIAKYGVACGVGYVVEYRGEAIDRLTMEERMTICNM 222
>LEU2_STRT2 (Q5M406) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 460 Score = 77.4 bits (189), Expect = 4e-14 Identities = 42/120 (35%), Positives = 62/120 (51%) Frame = +2 Query: 365 DYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKV 544 D +G+ H+ + G +PG+ ++ DSHT GAFG A GIG ++ V T Sbjct: 103 DKQGIVHMVGPETGRTQPGKFIVCGDSHTATHGAFGTIAFGIGTSEVEHVFATQTLWQVK 162 Query: 545 PPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 P + G + +KD IL +I + V+ +E+ G I+ LTMEERMT+CNM Sbjct: 163 PKKMLVEFTGNPQKGIYSKDYILALIAKYGVACGVGYVVEYRGEAIDRLTMEERMTICNM 222
>LEU2_STRMU (Q8DTG4) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 461 Score = 77.0 bits (188), Expect = 5e-14 Identities = 39/118 (33%), Positives = 63/118 (53%) Frame = +2 Query: 371 KGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPP 550 +G+ H+ + G +PG+ ++ DSHT GAFG GIG T+ V T P Sbjct: 105 QGIVHMVGPETGRTQPGKFIVCGDSHTATHGAFGAIGFGIGTTEVEHVFATQTIWQVKPK 164 Query: 551 TIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + G+ + +KD IL +I + V+ +E++G +++L+MEERMT+CNM Sbjct: 165 KLLVKFTGKPQKGVYSKDYILALIAKYGVALGVGYVVEYIGDAVDALSMEERMTICNM 222
>LEU2_AZOVI (P96195) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) Length = 470 Score = 76.3 bits (186), Expect = 9e-14 Identities = 42/107 (39%), Positives = 61/107 (57%) Frame = +2 Query: 404 GHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMP 583 G PG ++ DSHT G A GIG ++ V+ T + K ++ ++GE+P Sbjct: 119 GRHLPGMTVVCGDSHTSTHWC-GALAHGIGTSEVEHVLATQCLVAKKMKNMQVRVEGELP 177 Query: 584 PYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + AKD++L +IG I +G T ++EF GS I L+ME RMTLCNM Sbjct: 178 LGVSAKDIVLAVIGRIGTAGGTGHALEFAGSAIRGLSMEGRMTLCNM 224
>ACON_MOUSE (Q99KI0) Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3)| (Citrate hydro-lyase) (Aconitase) Length = 780 Score = 75.9 bits (185), Expect = 1e-13 Identities = 42/117 (35%), Positives = 62/117 (52%) Frame = +2 Query: 374 GVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPT 553 G+ H + E + PG +L+GTDSHT N G G G+G DA VM LK P Sbjct: 171 GIIH-QIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKV 229 Query: 554 IRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 I L G + + KD+IL++ G ++V G T +E+ G ++S++ T+CNM Sbjct: 230 IGVKLTGSLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNM 286
>ACON_PIG (P16276) Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3)| (Citrate hydro-lyase) (Aconitase) Length = 781 Score = 75.9 bits (185), Expect = 1e-13 Identities = 42/117 (35%), Positives = 62/117 (52%) Frame = +2 Query: 374 GVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPT 553 G+ H + E + PG +L+GTDSHT N G G G+G DA VM LK P Sbjct: 171 GIIH-QIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKV 229 Query: 554 IRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 I L G + + KD+IL++ G ++V G T +E+ G ++S++ T+CNM Sbjct: 230 IGVKLTGSLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNM 286
>ACON_RAT (Q9ER34) Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3)| (Citrate hydro-lyase) (Aconitase) Length = 780 Score = 75.5 bits (184), Expect = 2e-13 Identities = 42/117 (35%), Positives = 62/117 (52%) Frame = +2 Query: 374 GVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPT 553 G+ H + E + PG +L+GTDSHT N G G G+G DA VM LK P Sbjct: 171 GIIH-QIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKV 229 Query: 554 IRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 I L G + + KD+IL++ G ++V G T +E+ G ++S++ T+CNM Sbjct: 230 IGVKLTGTLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNM 286
>ACON_HUMAN (Q99798) Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3)| (Citrate hydro-lyase) (Aconitase) Length = 780 Score = 75.5 bits (184), Expect = 2e-13 Identities = 42/117 (35%), Positives = 62/117 (52%) Frame = +2 Query: 374 GVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPT 553 G+ H + E + PG +L+GTDSHT N G G G+G DA VM LK P Sbjct: 171 GIIH-QIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKV 229 Query: 554 IRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 I L G + + KD+IL++ G ++V G T +E+ G ++S++ T+CNM Sbjct: 230 IGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNM 286
>ACON_CAEEL (P34455) Probable aconitate hydratase, mitochondrial precursor (EC| 4.2.1.3) (Citrate hydro-lyase) (Aconitase) Length = 777 Score = 75.1 bits (183), Expect = 2e-13 Identities = 42/117 (35%), Positives = 63/117 (53%) Frame = +2 Query: 374 GVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPT 553 G+ H + E + PG +L+GTDSHT N G G G+G DA VM LK P Sbjct: 168 GIIH-QIILENYAFPGLLLIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKV 226 Query: 554 IRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 I L G++ + AKD+IL++ ++V G T +E+ G ++S++ T+CNM Sbjct: 227 IGIKLTGKLNGWTSAKDVILKVADILTVKGGTGAIVEYFGPGVDSISATGMGTICNM 283
>ACON_BOVIN (P20004) Aconitate hydratase, mitochondrial precursor (EC 4.2.1.3)| (Citrate hydro-lyase) (Aconitase) Length = 780 Score = 73.6 bits (179), Expect = 6e-13 Identities = 41/117 (35%), Positives = 61/117 (52%) Frame = +2 Query: 374 GVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPT 553 G+ H + E + PG +L+GTDSHT N G G G+G DA V LK P Sbjct: 171 GIIH-QIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVTAGIPWELKCPKV 229 Query: 554 IRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 I L G + + KD+IL++ G ++V G T +E+ G ++S++ T+CNM Sbjct: 230 IGVKLTGSLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNM 286
>LYS4_CANGA (Q6FM51) Homoaconitase, mitochondrial precursor (EC 4.2.1.36)| (Homoaconitate hydratase) Length = 689 Score = 73.2 bits (178), Expect = 8e-13 Identities = 56/230 (24%), Positives = 103/230 (44%), Gaps = 6/230 (2%) Frame = +2 Query: 53 TEKILARASERASLEPGENV----WVDVDV--LMTHDVCGPGTIGIFKQEFGEDAKVWDR 214 TEKI+ + S L PG+ V +V + +M+HD P + + G V D Sbjct: 21 TEKIVQQYS--VGLAPGKRVHSGDYVSIKPAHVMSHDNSWP--VALKFMNLGART-VKDP 75 Query: 215 EKVVIIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCHIAL 394 ++V DH I ++ + F ++ I ++ P +G+ H + Sbjct: 76 RQIVNTLDHDIQNKSDKNLTKYRNIESFAKKHGIDFY------------PAGRGIGHQIM 123 Query: 395 AQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDG 574 +EG+ P + + +DSH+ G G T + TDA + TG+ ++PP + G Sbjct: 124 VEEGYAFPLNLTVASDSHSNTYGGMGALGTPVVRTDAAAIWATGQTWWQIPPVAQVEFKG 183 Query: 575 EMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 ++ + KD+I+ + G + ++EF G I+ L ++ R+T+ NM Sbjct: 184 KLHESVSGKDIIVALCGVFNKDQVLNHAIEFTGDAIKHLPVDFRLTIANM 233
>ACON2_YEAST (P39533) Putative aconitase in PRP21-UBP12 intergenic region (EC| 4.2.1.3) Length = 789 Score = 71.6 bits (174), Expect = 2e-12 Identities = 40/117 (34%), Positives = 61/117 (52%) Frame = +2 Query: 374 GVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPT 553 G+ H + E PG ++LGTDSHT NAG G A G+G DA + LK P Sbjct: 168 GIIH-QIVLENFSAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKI 226 Query: 554 IRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + L G++ + KD+I ++ G ++V G T +E+ G + +L+ T+CNM Sbjct: 227 LGVKLTGKLNGWSTPKDVITKLAGLLTVRGGTGYIVEYFGEGVSTLSCTGMATICNM 283
>ACON1_ECOLI (P25516) Aconitate hydratase 1 (EC 4.2.1.3) (Citrate hydro-lyase 1)| (Aconitase 1) Length = 890 Score = 69.3 bits (168), Expect = 1e-11 Identities = 52/195 (26%), Positives = 84/195 (43%), Gaps = 16/195 (8%) Frame = +2 Query: 188 GEDAKVWDREKVVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 G+ AKV V ++ DH + F DE NV + + E+ + + + S F Sbjct: 111 GDTAKVNPLSPVDLVIDHSVTVDRFGDDEAFEENVRLEMERNHERYVFLKWGKQAFSRFS 170 Query: 356 ANPDYKGVCH------IALAQEGHCRPGE------VLLGTDSHTCNAGAFGQFATGIGNT 499 P G+CH + A + GE L+GTDSHT G G+G Sbjct: 171 VVPPGTGICHQVNLEYLGKAVWSELQDGEWIAYPDTLVGTDSHTTMINGLGVLGWGVGGI 230 Query: 500 DAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGST 679 +A M + +P + F L G++ + A DL+L + + G + +EF G Sbjct: 231 EAEAAMLGQPVSMLIPDVVGFKLTGKLREGITATDLVLTVTQMLRKHGVVGKFVEFYGDG 290 Query: 680 IESLTMEERMTLCNM 724 ++SL + +R T+ NM Sbjct: 291 LDSLPLADRATIANM 305
>ACON_COREF (Q8FTA8) Aconitate hydratase (EC 4.2.1.3)| Length = 937 Score = 65.5 bits (158), Expect = 2e-10 Identities = 60/245 (24%), Positives = 103/245 (42%), Gaps = 20/245 (8%) Frame = +2 Query: 50 TTEKILARASERASLEPGENVWVDVDVLMTHDVCG-PGTIGI------FKQEFGEDAKVW 208 T E I A A+ AS +P + ++ D G P + + K G+ KV Sbjct: 56 TEEHIEAIANWDASADPSIEIQFTPARVLMQDFTGVPCVVDLATMREAVKTLGGDPDKVN 115 Query: 209 DREKVVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKG 376 ++ DH + F + +NV+I + +E+ + + S+FR P G Sbjct: 116 PLNPAEMVIDHSVIVEAFGRPDALEKNVEIEYERNEERYQFLRWGSEAFSNFRVVPPGTG 175 Query: 377 VCH---------IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGK 529 + H + +G P + +GTDSHT G G+G +A M Sbjct: 176 IVHQVNIEYLARVVFDNDGLAYP-DTCIGTDSHTTMENGLGILGWGVGGIEAEAAMLGQP 234 Query: 530 ALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERM 709 + +P + F L GE+P + A D++L I + G + +EF G+ ++S+ + R Sbjct: 235 VSMLIPRVVGFKLTGEIPVGVTATDVVLTITEMLRDHGVVQKFVEFYGNGVKSVPLANRA 294 Query: 710 TLCNM 724 T+ NM Sbjct: 295 TIGNM 299
>ACON_CORDI (Q6NH63) Aconitate hydratase (EC 4.2.1.3)| Length = 934 Score = 64.3 bits (155), Expect = 4e-10 Identities = 49/192 (25%), Positives = 83/192 (43%), Gaps = 13/192 (6%) Frame = +2 Query: 188 GEDAKVWDREKVVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 G+ KV ++ DH + F + +NV+I + +E+ + K S+FR Sbjct: 109 GDPDKVNPLNPAEMVIDHSVIIEAFGSTLALAKNVEIEYERNEERYQFLRWGSKAFSNFR 168 Query: 356 ANPDYKGVCH---------IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAG 508 P G+ H + G P + +GTDSHT G G+G +A Sbjct: 169 VVPPGTGIVHQVNIENLARVVFDNNGLAYP-DTCIGTDSHTTMENGLGILGWGVGGIEAE 227 Query: 509 FVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIES 688 M + +P + F L GE+P + A D++L I + G + +EF G+ ++S Sbjct: 228 AAMLGQPVSMLIPRVVGFKLTGEIPAGVTATDVVLTITEMLREHGVVQKFVEFYGNGVKS 287 Query: 689 LTMEERMTLCNM 724 + + R T+ NM Sbjct: 288 IPLANRATIGNM 299
>ACON_CORGL (Q8NQ98) Aconitate hydratase (EC 4.2.1.3)| Length = 939 Score = 63.9 bits (154), Expect = 5e-10 Identities = 46/179 (25%), Positives = 80/179 (44%), Gaps = 13/179 (7%) Frame = +2 Query: 227 IIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCH--- 385 ++ DH + F + +NV+I + +E+ + + S+FR P G+ H Sbjct: 122 MVIDHSVIVEAFGRPDALAKNVEIEYERNEERYQFLRWGSESFSNFRVVPPGTGIVHQVN 181 Query: 386 ------IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVP 547 + EG P + +GTDSHT G G+G +A M + +P Sbjct: 182 IEYLARVVFDNEGLAYP-DTCIGTDSHTTMENGLGILGWGVGGIEAEAAMLGQPVSMLIP 240 Query: 548 PTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + F L GE+P + A D++L I + G + +EF GS ++++ + R T+ NM Sbjct: 241 RVVGFKLTGEIPVGVTATDVVLTITEMLRDHGVVQKFVEFYGSGVKAVPLANRATIGNM 299
>ACON_STRMU (Q59938) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 888 Score = 61.2 bits (147), Expect = 3e-09 Identities = 44/181 (24%), Positives = 80/181 (44%), Gaps = 13/181 (7%) Frame = +2 Query: 221 VVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFRANPDYKGVCH- 385 V ++ DH + F + + N+D+ + E+ + K ++RA P G+ H Sbjct: 118 VDLVIDHSVQVDFFGNQDAFDANIDLEFERNNERYEFLKWAEKTFENYRAVPPATGIIHQ 177 Query: 386 --------IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLK 541 + + ++G P + + GTDSHT G G+G +A M + Sbjct: 178 VNLEFLSDVIINKDGFLYP-DSMFGTDSHTTMINGIGVLGWGVGGIEAEAAMLGEASYFP 236 Query: 542 VPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCN 721 +P I L GE+P A DL L++ ++ + + +EF G + L++ +R T+ N Sbjct: 237 IPEVIGVRLYGELPKVATATDLALKVTQKLRLENVVGKFVEFFGPGLAGLSLADRATVAN 296 Query: 722 M 724 M Sbjct: 297 M 297
>ACON_LEGPH (P37032) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) (Major iron-containing protein) (MICP) (IP210) Length = 891 Score = 58.9 bits (141), Expect = 2e-08 Identities = 40/143 (27%), Positives = 63/143 (44%), Gaps = 13/143 (9%) Frame = +2 Query: 335 KDLSDFRANPDYKGVCH-IALAQEG------------HCRPGEVLLGTDSHTCNAGAFGQ 475 K S+F+ P G+CH + L G + P + L+GTDSHT G Sbjct: 167 KAFSNFQVVPPGTGICHQVNLEYLGKTVWNSENDGQLYAYP-DTLVGTDSHTTMINGLGV 225 Query: 476 FATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYR 655 G+G +A M + +P I F L G++ + A DL+L + + G + Sbjct: 226 LGWGVGGIEAEAAMLGQPVSMLIPEVIGFKLSGKLKEGITATDLVLTVTQMLRKKGVVGK 285 Query: 656 SMEFVGSTIESLTMEERMTLCNM 724 +EF G + L + +R T+ NM Sbjct: 286 FVEFYGPGLNDLPLADRATISNM 308
>IREB1_CHICK (Q90875) Iron-responsive element binding protein (IRE-BP) (Iron| regulatory protein) (IRP) (Ferritin repressor protein) (Aconitate hydratase) (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase) Length = 889 Score = 58.2 bits (139), Expect = 3e-08 Identities = 44/179 (24%), Positives = 78/179 (43%), Gaps = 13/179 (7%) Frame = +2 Query: 227 IIPDHYIFTADERANRNVDILRDFCQEQKIKYFYDIK----DLSDFRANPDYKGVCH--- 385 ++ DH I R + ++ +D E+ + F +K + R P G+ H Sbjct: 122 LVIDHSIQVDFNRRSDSLQKNQDLEFERNKERFEFLKWGSQAFKNMRIIPPGSGIIHQVN 181 Query: 386 ------IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVP 547 + + Q+G+ P V+ GTDSHT G G+G +A VM + +P Sbjct: 182 LEYLARVVMDQDGYYYPDSVV-GTDSHTTMVDGLGVLGWGVGGIEAEAVMLGQPISMVLP 240 Query: 548 PTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + + L G P + + D++L I + G + +EF G + L++ +R T+ NM Sbjct: 241 EVVGYKLLGNPQPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANM 299
>IREB1_RABIT (Q01059) Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron| regulatory protein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase) (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase) Length = 889 Score = 57.4 bits (137), Expect = 4e-08 Identities = 38/139 (27%), Positives = 63/139 (45%), Gaps = 9/139 (6%) Frame = +2 Query: 335 KDLSDFRANPDYKGVCH---------IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATG 487 K + R P G+ H + Q+G+ P + L+GTDSHT G G Sbjct: 162 KAFRNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYP-DSLVGTDSHTTMIDGLGVLGWG 220 Query: 488 IGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEF 667 +G +A VM + +P I + L G+ P + + D++L I + G + +EF Sbjct: 221 VGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEF 280 Query: 668 VGSTIESLTMEERMTLCNM 724 G + L++ +R T+ NM Sbjct: 281 FGLGVAQLSIADRATIANM 299
>LEU2_RHIET (Q8VMA6) 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)| (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) (Fragment) Length = 174 Score = 57.0 bits (136), Expect = 6e-08 Identities = 42/159 (26%), Positives = 73/159 (45%), Gaps = 5/159 (3%) Frame = +2 Query: 122 VDVLMTHDVCGPGTIGIFKQEFGEDAKVWDREKVVIIPDHYIFTADERANRNVDILRDFC 301 +D + H+V P + KV EK + + DH + T+ +R ++ I + Sbjct: 23 IDRHLVHEVTSPQAFEGLRMS---GRKVRAPEKTLAVVDHNVPTSPDR---HLGIKNE-- 74 Query: 302 QEQKIKYFYDIKDLSDFRA-----NPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGA 466 E +I+ K+ ++F N +G+ HI ++G PG ++ DSHT GA Sbjct: 75 -ESRIQVEQLAKNAAEFNVEYYSENDKRQGIVHIIGPEQGFTLPGMTIVCGDSHTSTHGA 133 Query: 467 FGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMP 583 FG A GIG ++ V+ T + K + +DG++P Sbjct: 134 FGSLAHGIGTSEVEHVLATQTLIQKKAKNMLVQVDGQLP 172
>ACON_STAAW (P63434) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 901 Score = 57.0 bits (136), Expect = 6e-08 Identities = 48/195 (24%), Positives = 79/195 (40%), Gaps = 16/195 (8%) Frame = +2 Query: 188 GEDAKVWDREKVVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 G+ K+ V ++ DH + + E RN+ + + E+ + K ++ Sbjct: 112 GDITKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYN 171 Query: 356 ANPDYKGVCHIA----LAQEGHCRP--------GEVLLGTDSHTCNAGAFGQFATGIGNT 499 A P G+ H LA H R + L+GTDSHT G G+G Sbjct: 172 AVPPATGIVHQVNLEYLASVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGI 231 Query: 500 DAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGST 679 +A M + +P I L +P A DL L++ E+ G + +EF G Sbjct: 232 EAEAGMLGQPSYFPIPEVIGVRLVNSLPQGATATDLALRVTQELRKKGVVGKFVEFFGPG 291 Query: 680 IESLTMEERMTLCNM 724 ++ L + +R T+ NM Sbjct: 292 VQHLPLADRATIANM 306
>ACON_STAAS (Q6G9K9) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 901 Score = 57.0 bits (136), Expect = 6e-08 Identities = 48/195 (24%), Positives = 79/195 (40%), Gaps = 16/195 (8%) Frame = +2 Query: 188 GEDAKVWDREKVVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 G+ K+ V ++ DH + + E RN+ + + E+ + K ++ Sbjct: 112 GDITKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYN 171 Query: 356 ANPDYKGVCHIA----LAQEGHCRP--------GEVLLGTDSHTCNAGAFGQFATGIGNT 499 A P G+ H LA H R + L+GTDSHT G G+G Sbjct: 172 AVPPATGIVHQVNLEYLASVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGI 231 Query: 500 DAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGST 679 +A M + +P I L +P A DL L++ E+ G + +EF G Sbjct: 232 EAEAGMLGQPSYFPIPEVIGVRLVNSLPQGATATDLALRVTQELRKKGVVGKFVEFFGPG 291 Query: 680 IESLTMEERMTLCNM 724 ++ L + +R T+ NM Sbjct: 292 VQHLPLADRATIANM 306
>ACON_STAAR (Q6GH55) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 901 Score = 57.0 bits (136), Expect = 6e-08 Identities = 48/195 (24%), Positives = 79/195 (40%), Gaps = 16/195 (8%) Frame = +2 Query: 188 GEDAKVWDREKVVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 G+ K+ V ++ DH + + E RN+ + + E+ + K ++ Sbjct: 112 GDITKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYN 171 Query: 356 ANPDYKGVCHIA----LAQEGHCRP--------GEVLLGTDSHTCNAGAFGQFATGIGNT 499 A P G+ H LA H R + L+GTDSHT G G+G Sbjct: 172 AVPPATGIVHQVNLEYLASVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGI 231 Query: 500 DAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGST 679 +A M + +P I L +P A DL L++ E+ G + +EF G Sbjct: 232 EAEAGMLGQPSYFPIPEVIGVRLVNSLPQGATATDLALRVTQELRKKGVVGKFVEFFGPG 291 Query: 680 IESLTMEERMTLCNM 724 ++ L + +R T+ NM Sbjct: 292 VQHLPLADRATIANM 306
>ACON_STAAN (P99148) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 901 Score = 57.0 bits (136), Expect = 6e-08 Identities = 48/195 (24%), Positives = 79/195 (40%), Gaps = 16/195 (8%) Frame = +2 Query: 188 GEDAKVWDREKVVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 G+ K+ V ++ DH + + E RN+ + + E+ + K ++ Sbjct: 112 GDITKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYN 171 Query: 356 ANPDYKGVCHIA----LAQEGHCRP--------GEVLLGTDSHTCNAGAFGQFATGIGNT 499 A P G+ H LA H R + L+GTDSHT G G+G Sbjct: 172 AVPPATGIVHQVNLEYLASVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGI 231 Query: 500 DAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGST 679 +A M + +P I L +P A DL L++ E+ G + +EF G Sbjct: 232 EAEAGMLGQPSYFPIPEVIGVRLVNSLPQGATATDLALRVTQELRKKGVVGKFVEFFGPG 291 Query: 680 IESLTMEERMTLCNM 724 ++ L + +R T+ NM Sbjct: 292 VQHLPLADRATIANM 306
>ACON_STAAM (P63433) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 901 Score = 57.0 bits (136), Expect = 6e-08 Identities = 48/195 (24%), Positives = 79/195 (40%), Gaps = 16/195 (8%) Frame = +2 Query: 188 GEDAKVWDREKVVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 G+ K+ V ++ DH + + E RN+ + + E+ + K ++ Sbjct: 112 GDITKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYN 171 Query: 356 ANPDYKGVCHIA----LAQEGHCRP--------GEVLLGTDSHTCNAGAFGQFATGIGNT 499 A P G+ H LA H R + L+GTDSHT G G+G Sbjct: 172 AVPPATGIVHQVNLEYLASVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGI 231 Query: 500 DAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGST 679 +A M + +P I L +P A DL L++ E+ G + +EF G Sbjct: 232 EAEAGMLGQPSYFPIPEVIGVRLVNSLPQGATATDLALRVTQELRKKGVVGKFVEFFGPG 291 Query: 680 IESLTMEERMTLCNM 724 ++ L + +R T+ NM Sbjct: 292 VQHLPLADRATIANM 306
>ACON_STAAC (Q5HG69) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 901 Score = 57.0 bits (136), Expect = 6e-08 Identities = 48/195 (24%), Positives = 79/195 (40%), Gaps = 16/195 (8%) Frame = +2 Query: 188 GEDAKVWDREKVVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 G+ K+ V ++ DH + + E RN+ + + E+ + K ++ Sbjct: 112 GDITKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYN 171 Query: 356 ANPDYKGVCHIA----LAQEGHCRP--------GEVLLGTDSHTCNAGAFGQFATGIGNT 499 A P G+ H LA H R + L+GTDSHT G G+G Sbjct: 172 AVPPATGIVHQVNLEYLASVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGI 231 Query: 500 DAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGST 679 +A M + +P I L +P A DL L++ E+ G + +EF G Sbjct: 232 EAEAGMLGQPSYFPIPEVIGVRLVNSLPQGATATDLALRVTQELRKKGVVGKFVEFFGPG 291 Query: 680 IESLTMEERMTLCNM 724 ++ L + +R T+ NM Sbjct: 292 VQHLPLADRATIANM 306
>IREB1_HUMAN (P21399) Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron| regulatory protein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase) (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase) Length = 889 Score = 56.6 bits (135), Expect = 8e-08 Identities = 33/116 (28%), Positives = 57/116 (49%) Frame = +2 Query: 377 VCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTI 556 + + Q+G+ P + L+GTDSHT G G+G +A VM + +P I Sbjct: 185 LARVVFDQDGYYYP-DSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVI 243 Query: 557 RFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + L G+ P + + D++L I + G + +EF G + L++ +R T+ NM Sbjct: 244 GYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANM 299
>IREB1_RAT (Q63270) Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron| regulatory protein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase) (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase) Length = 889 Score = 56.2 bits (134), Expect = 1e-07 Identities = 33/116 (28%), Positives = 56/116 (48%) Frame = +2 Query: 377 VCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTI 556 + + Q+G C + L+GTDSHT G G+G +A VM + +P I Sbjct: 185 LARVVFDQDG-CYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVI 243 Query: 557 RFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + L G+ P + + D++L I + G + +EF G + L++ +R T+ NM Sbjct: 244 GYKLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANM 299
>IREB1_MOUSE (P28271) Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron| regulatory protein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase) (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase) Length = 889 Score = 56.2 bits (134), Expect = 1e-07 Identities = 33/116 (28%), Positives = 56/116 (48%) Frame = +2 Query: 377 VCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTI 556 + + Q+G C + L+GTDSHT G G+G +A VM + +P I Sbjct: 185 LARVVFDQDG-CYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVI 243 Query: 557 RFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 + L G+ P + + D++L I + G + +EF G + L++ +R T+ NM Sbjct: 244 GYKLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANM 299
>ACON_STAES (Q8CPC2) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 901 Score = 55.8 bits (133), Expect = 1e-07 Identities = 48/195 (24%), Positives = 79/195 (40%), Gaps = 16/195 (8%) Frame = +2 Query: 188 GEDAKVWDREKVVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 G+ K+ V ++ DH + + E RN+ + + E+ + K ++ Sbjct: 112 GDINKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYN 171 Query: 356 ANPDYKGVCHIA----LAQEGHCRP--------GEVLLGTDSHTCNAGAFGQFATGIGNT 499 A P G+ H LA H R + L+GTDSHT G G+G Sbjct: 172 AVPPATGIVHQVNLEYLANVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGI 231 Query: 500 DAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGST 679 +A M + +P I L +P A DL L++ E+ G + +EF G Sbjct: 232 EAEAGMLGQPSYFPIPEVIGVRLTHSLPQGSTATDLALRVTEELRKKGVVGKFVEFFGPG 291 Query: 680 IESLTMEERMTLCNM 724 ++ L + +R T+ NM Sbjct: 292 VQHLPLADRATIANM 306
>ACON_STAEQ (Q5HPJ0) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 901 Score = 55.8 bits (133), Expect = 1e-07 Identities = 48/195 (24%), Positives = 79/195 (40%), Gaps = 16/195 (8%) Frame = +2 Query: 188 GEDAKVWDREKVVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 G+ K+ V ++ DH + + E RN+ + + E+ + K ++ Sbjct: 112 GDINKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYN 171 Query: 356 ANPDYKGVCHIA----LAQEGHCRP--------GEVLLGTDSHTCNAGAFGQFATGIGNT 499 A P G+ H LA H R + L+GTDSHT G G+G Sbjct: 172 AVPPATGIVHQVNLEYLANVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGI 231 Query: 500 DAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGST 679 +A M + +P I L +P A DL L++ E+ G + +EF G Sbjct: 232 EAEAGMLGQPSYFPIPEVIGVRLTHSLPQGSTATDLALRVTEELRKKGVVGKFVEFFGPG 291 Query: 680 IESLTMEERMTLCNM 724 ++ L + +R T+ NM Sbjct: 292 VQHLPLADRATIANM 306
>ACON_FRATH (Q2A1K3) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 937 Score = 55.5 bits (132), Expect = 2e-07 Identities = 29/101 (28%), Positives = 51/101 (50%) Frame = +2 Query: 422 EVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAK 601 + L+GTDSHT G G+G +A VM + +P + G++ + A Sbjct: 206 DTLVGTDSHTTMINGVGAVGWGVGGIEAEAVMLGQPYYMVLPDVVGVKFTGKLKTGVTAT 265 Query: 602 DLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 DL+L++ + G + +E+ G +ESL++ +R T+ NM Sbjct: 266 DLVLKVTEVLRKHGVVGKFVEYYGEGLESLSLPDRATIANM 306
>ACON_RICCN (Q92G90) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 878 Score = 55.1 bits (131), Expect = 2e-07 Identities = 44/192 (22%), Positives = 82/192 (42%), Gaps = 13/192 (6%) Frame = +2 Query: 188 GEDAKVWDREKVVIIPDHYI----FTADERANRNVDILRDFCQEQKIKYFYDIKDLSDFR 355 G+ K+ V ++ DH + + A + N+NV + E+ + + ++F+ Sbjct: 109 GDPLKINPLIPVDLVIDHSVSVDSYAAKDSFNKNVQMEMKRNIERYAFLKWGQQAFNNFK 168 Query: 356 ANPDYKGVCH---------IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAG 508 P G+CH + ++G P + L+GTDSHT G+G +A Sbjct: 169 VVPPGTGICHQVNLEYLAKVVWHKDGTLYP-DSLVGTDSHTTMVNGLSVLGWGVGGIEAE 227 Query: 509 FVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIES 688 M + +P I L G++ A DL+L + + + +EF G +++ Sbjct: 228 AAMLGQPLTMILPEVIGVKLTGKLTGIATATDLVLTVTEMLRKKKVVGKFVEFFGEGLKN 287 Query: 689 LTMEERMTLCNM 724 L + +R T+ NM Sbjct: 288 LMIADRATISNM 299
>ACON_CORJK (Q4JVM4) Aconitate hydratase (EC 4.2.1.3)| Length = 936 Score = 54.3 bits (129), Expect = 4e-07 Identities = 30/101 (29%), Positives = 47/101 (46%) Frame = +2 Query: 422 EVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAK 601 + +GTDSHT G G+G +A M + +P + F L GE+P + A Sbjct: 199 DTCVGTDSHTTMENGLGILGWGVGGIEAEAAMLGQPISMLIPRVVGFKLTGEIPTGVTAT 258 Query: 602 DLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 D++L I + G + +EF G + L + R T+ NM Sbjct: 259 DVVLTITDMLRQHGVVGKFVEFYGKGVGELPLANRATIGNM 299
>ACOC_CAEEL (Q23500) Probable aconitate hydratase, cytoplasmic (EC 4.2.1.3)| (Citrate hydro-lyase) (Aconitase) Length = 887 Score = 54.3 bits (129), Expect = 4e-07 Identities = 33/113 (29%), Positives = 56/113 (49%) Frame = +2 Query: 386 IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFV 565 + + ++G P V+ GTDSHT G G+G +A VM + +P I + Sbjct: 187 VFVGKDGVLYPDSVV-GTDSHTTMIDGSGVLGWGVGGIEAEAVMLGQPISMVIPEVIGYE 245 Query: 566 LDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 L G + + + DL+L I + G + +EF G+ + SL++ +R T+ NM Sbjct: 246 LVGTLSDTVTSTDLVLTITKNLRDLGVVGKFVEFFGTGVASLSIADRATIANM 298
>ACON_BACSU (P09339) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 908 Score = 53.9 bits (128), Expect = 5e-07 Identities = 42/142 (29%), Positives = 62/142 (43%), Gaps = 12/142 (8%) Frame = +2 Query: 335 KDLSDFRANPDYKGVCHIA----LAQEGHC--RPGEV------LLGTDSHTCNAGAFGQF 478 K ++++A P G+ H LA H GE+ L+GTDSHT G Sbjct: 171 KAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGTDSHTTMINGIGVL 230 Query: 479 ATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRS 658 G+G +A M + VP I L G++P A DL L++ + G + Sbjct: 231 GWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLALKVTQVLREKGVVGKF 290 Query: 659 MEFVGSTIESLTMEERMTLCNM 724 +EF G I L + +R T+ NM Sbjct: 291 VEFFGPGIAELPLADRATIANM 312
>ACON_RICPR (Q9ZCF4) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 878 Score = 53.9 bits (128), Expect = 5e-07 Identities = 36/136 (26%), Positives = 60/136 (44%), Gaps = 9/136 (6%) Frame = +2 Query: 344 SDFRANPDYKGVCH---------IALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGN 496 ++F+ P G+CH + +G P + L+GTDSHT G+G Sbjct: 165 NNFKVVPPGTGICHQVNLEFLSQVVWHNDGTAYP-DSLVGTDSHTTMVNGLSVLGWGVGG 223 Query: 497 TDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGS 676 +A M + +P I L G++ A DL+L I + + +EF G+ Sbjct: 224 IEAESAMLGQPITMIIPEVIGVKLIGKLAGMATATDLVLTITEILRRKKVVGKFVEFFGN 283 Query: 677 TIESLTMEERMTLCNM 724 + +LT+ +R T+ NM Sbjct: 284 GLRNLTISDRATISNM 299
>ACOC_CUCMA (P49608) Aconitate hydratase, cytoplasmic (EC 4.2.1.3) (Citrate| hydro-lyase) (Aconitase) Length = 898 Score = 53.5 bits (127), Expect = 6e-07 Identities = 35/124 (28%), Positives = 57/124 (45%) Frame = +2 Query: 353 RANPDYKGVCHIALAQEGHCRPGEVLLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKA 532 + N +Y G + G P V+ GTDSHT G G+G +A M Sbjct: 183 QVNLEYLG--RVVFNTSGLLYPDSVV-GTDSHTTMIDGLGVAGWGVGGIEAEAAMLGQPM 239 Query: 533 LLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVSGATYRSMEFVGSTIESLTMEERMT 712 + +P + F L G++ + A DL+L + + G + +EF G +E L++ +R T Sbjct: 240 SMVLPGVVGFKLSGKLRNGVTATDLVLTVTQMLRKHGVVGKFVEFYGDGMEELSLADRAT 299 Query: 713 LCNM 724 + NM Sbjct: 300 IANM 303
>IREB2_HUMAN (P48200) Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron| regulatory protein 2) (IRP2) Length = 963 Score = 50.8 bits (120), Expect = 4e-06 Identities = 28/99 (28%), Positives = 47/99 (47%) Frame = +2 Query: 428 LLGTDSHTCNAGAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDL 607 ++GTDSH G G+G + VM L +P + L G P++ + D+ Sbjct: 276 VVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDV 335 Query: 608 ILQIIGEISVSGATYRSMEFVGSTIESLTMEERMTLCNM 724 +L I + G + +EF GS + L++ +R T+ NM Sbjct: 336 VLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANM 374
>ACON_BRAJA (P70920) Aconitate hydratase (EC 4.2.1.3) (Citrate hydro-lyase)| (Aconitase) Length = 906 Score = 50.8 bits (120), Expect = 4e-06 Identities = 50/208 (24%), Positives = 87/208 (41%), Gaps = 26/208 (12%) Frame = +2 Query: 179 QEFGEDA-KVWDREKVVIIPDHYI---FTADERANRNVDILRDFCQEQKIKYF--YDIKD 340 Q+ G DA K+ V ++ DH + F D +A ++ ++ Q Q+ F + Sbjct: 109 QKLGGDAEKINPLVPVDLVIDHSVIVNFFGDNKAFAK-NVTEEYKQNQERYEFLKWGQAA 167 Query: 341 LSDFRANPDYKGVCHIA----LAQEGHCRPGEV----------------LLGTDSHTCNA 460 S+F P G+CH L+Q + ++ L+GTDSHT Sbjct: 168 FSNFSVVPPGTGICHQVNLEYLSQTVWTKKEKMTVGKKTGTFEVAYPDSLVGTDSHTTMV 227 Query: 461 GAFGQFATGIGNTDAGFVMGTGKALLKVPPTIRFVLDGEMPPYLLAKDLILQIIGEISVS 640 G+G +A M + +P + F L G M + A DL+L + + Sbjct: 228 NGLAVLGWGVGGIEAEACMLGQPLSMLLPNVVGFKLKGAMKEGVTATDLVLTVTQMLRKL 287 Query: 641 GATYRSMEFVGSTIESLTMEERMTLCNM 724 G + +EF G ++ L++ ++ T+ NM Sbjct: 288 GVVGKFVEFFGPGLDHLSVADKATIANM 315 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 88,056,309 Number of Sequences: 219361 Number of extensions: 1917720 Number of successful extensions: 5968 Number of sequences better than 10.0: 275 Number of HSP's better than 10.0 without gapping: 5661 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5895 length of database: 80,573,946 effective HSP length: 109 effective length of database: 56,663,597 effective search space used: 7479594804 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
