ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bah63e11 |
|---|---|
| Clone Library Name | barley_pub |
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 114 bits (286), Expect = 1e-25 Identities = 71/150 (47%), Positives = 91/150 (60%), Gaps = 9/150 (6%) Frame = +2 Query: 56 SVAESPKLQSPSERIEKDDSL--------LPSNPR-EVEALRNDSARKNPLIAFTFEELK 208 S SPK S E +DSL + +NPR E E L++ + + +FTF ELK Sbjct: 13 SPGASPKYMSS----EANDSLGSKSSSVSIRTNPRTEGEILQSPNLK-----SFTFAELK 63 Query: 209 RITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLA 388 T+NFR DSVLG GGFG V+KG + + +AVK + D +QGH+EWLA Sbjct: 64 AATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPGTGVVIAVKKLNQDG-WQGHQEWLA 122 Query: 389 EVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 EV +LGQ SHPNLVKL+GYC ED+HR+LVY Sbjct: 123 EVNYLGQFSHPNLVKLIGYCLEDEHRLLVY 152
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 106 bits (265), Expect = 3e-23 Identities = 60/122 (49%), Positives = 79/122 (64%) Frame = +2 Query: 113 SLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVAND 292 S+ PS E E L++ + + +F+F ELK T+NFR DSVLG GGFG V+KG + Sbjct: 36 SVRPSPRTEGEILQSPNLK-----SFSFAELKSATRNFRPDSVLGEGGFGCVFKGWIDEK 90 Query: 293 LREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVL 472 L +AVK + D +QGH+EWLAEV +LGQ SH +LVKL+GYC ED+HR+L Sbjct: 91 SLTASRPGTGLVIAVKKLNQDG-WQGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLL 149 Query: 473 VY 478 VY Sbjct: 150 VY 151
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 106 bits (265), Expect = 3e-23 Identities = 59/117 (50%), Positives = 76/117 (64%), Gaps = 3/117 (2%) Frame = +2 Query: 137 EVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIE 316 E E L+N + + F+ ELK T+NFR DSV+G GGFG V+KG + LA Sbjct: 44 EGEILQNANLKN-----FSLSELKSATRNFRPDSVVGEGGFGCVFKGWIDES---SLAPS 95 Query: 317 EP---LRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 +P + +AVK FQGHREWLAE+ +LGQL HPNLVKL+GYC E++HR+LVY Sbjct: 96 KPGTGIVIAVK-RLNQEGFQGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVY 151
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 89.4 bits (220), Expect = 5e-18 Identities = 49/100 (49%), Positives = 63/100 (63%) Frame = +2 Query: 179 LIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDN 358 L + F +LK TKNF+ DS+LG GGFG+VY+G V + + VA+K + + Sbjct: 71 LKVYNFLDLKTATKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIKRLNSE- 129 Query: 359 SFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 S QG EW +EV FLG LSH NLVKL+GYC ED +LVY Sbjct: 130 SVQGFAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVY 169
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 86.7 bits (213), Expect = 3e-17 Identities = 54/138 (39%), Positives = 73/138 (52%), Gaps = 11/138 (7%) Frame = +2 Query: 98 IEKDDSLLPSNPREVEALRNDSARKNPLI-----------AFTFEELKRITKNFRQDSVL 244 + + S LPS ++ + N +++ L+ F F EL T NF D+ L Sbjct: 33 VSNNISGLPSGGEKLSSKTNGGSKRELLLPRDGLGQIAAHTFAFRELAAATMNFHPDTFL 92 Query: 245 GVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPN 424 G GGFGRVYKG + + + VAVK D N QG+RE+L EV+ L L HPN Sbjct: 93 GEGGFGRVYKGRLDSTGQV---------VAVKQLDR-NGLQGNREFLVEVLMLSLLHHPN 142 Query: 425 LVKLVGYCCEDDHRVLVY 478 LV L+GYC + D R+LVY Sbjct: 143 LVNLIGYCADGDQRLLVY 160
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 86.3 bits (212), Expect = 4e-17 Identities = 58/170 (34%), Positives = 83/170 (48%), Gaps = 15/170 (8%) Frame = +2 Query: 14 RESVLQQGFFHATKSVAESPKLQSPSERIEKDDSLLPSNP--------------REVEAL 151 +++V+ + T SVA+S K ++ + P +V+ L Sbjct: 18 KDTVINRKIVGGTTSVAKSDKRDDQTQPSSDSTKVSPYRDVNNEGGVGKEDQLSLDVKGL 77 Query: 152 R-NDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLR 328 ND FTF+EL T NFR D LG GGFG+V+KG + L + +AI++ R Sbjct: 78 NLNDQVTGKKAQTFTFQELAEATGNFRSDCFLGEGGFGKVFKGTIEK-LDQVVAIKQLDR 136 Query: 329 VAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 N QG RE++ EV+ L HPNLVKL+G+C E D R+LVY Sbjct: 137 ---------NGVQGIREFVVEVLTLSLADHPNLVKLIGFCAEGDQRLLVY 177
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 73.9 bits (180), Expect = 2e-13 Identities = 44/108 (40%), Positives = 62/108 (57%) Frame = +2 Query: 155 NDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVA 334 N +A + PL TF +L + T F DS++G GGFG VYK L++G A+ + Sbjct: 860 NLAAFEKPLRKLTFADLLQATNGFHNDSLIGSGGFGDVYKAI----LKDGSAVAIKKLIH 915 Query: 335 VKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 V S QG RE++AE+ +G++ H NLV L+GYC D R+LVY Sbjct: 916 V-------SGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVY 956
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 70.1 bits (170), Expect = 3e-12 Identities = 44/110 (40%), Positives = 63/110 (57%), Gaps = 2/110 (1%) Frame = +2 Query: 155 NDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREG--LAIEEPLR 328 N +A + PL TF +L T F DS++G GGFG VYK L++G +AI++ + Sbjct: 865 NLAAFEKPLRKLTFADLLEATNGFHNDSLVGSGGFGDVYKA----QLKDGSVVAIKKLIH 920 Query: 329 VAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 V S QG RE+ AE+ +G++ H NLV L+GYC + R+LVY Sbjct: 921 V---------SGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVY 961
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 70.1 bits (170), Expect = 3e-12 Identities = 44/110 (40%), Positives = 63/110 (57%), Gaps = 2/110 (1%) Frame = +2 Query: 155 NDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREG--LAIEEPLR 328 N +A + PL TF +L T F DS++G GGFG VYK L++G +AI++ + Sbjct: 865 NLAAFEKPLRKLTFADLLEATNGFHNDSLVGSGGFGDVYKA----QLKDGSVVAIKKLIH 920 Query: 329 VAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 V S QG RE+ AE+ +G++ H NLV L+GYC + R+LVY Sbjct: 921 V---------SGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVY 961
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 68.9 bits (167), Expect = 6e-12 Identities = 37/103 (35%), Positives = 59/103 (57%) Frame = +2 Query: 170 KNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHD 349 + PL+ ++ T +F + +++G GGFG VYK C+ + VAVK Sbjct: 899 EQPLLKVRLGDIVEATDHFSKKNIIGDGGFGTVYKACLPGEKT----------VAVKKLS 948 Query: 350 GDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 + QG+RE++AE+ LG++ HPNLV L+GYC + ++LVY Sbjct: 949 -EAKTQGNREFMAEMETLGKVKHPNLVSLLGYCSFSEEKLLVY 990
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 68.9 bits (167), Expect = 6e-12 Identities = 41/97 (42%), Positives = 57/97 (58%) Frame = +2 Query: 188 FTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQ 367 F + E+ IT NF + V+G GGFG+VY G + + +VAVKV + S Q Sbjct: 564 FKYSEVVNITNNFER--VIGKGGFGKVYHGVINGE-----------QVAVKVLS-EESAQ 609 Query: 368 GHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 G++E+ AEV L ++ H NL LVGYC E +H VL+Y Sbjct: 610 GYKEFRAEVDLLMRVHHTNLTSLVGYCNEINHMVLIY 646
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 68.2 bits (165), Expect = 1e-11 Identities = 41/110 (37%), Positives = 63/110 (57%), Gaps = 2/110 (1%) Frame = +2 Query: 155 NDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREG--LAIEEPLR 328 N + + PL TF L T F ++++G GGFG VYK LR+G +AI++ +R Sbjct: 836 NVATFEKPLRKLTFAHLLEATNGFSAETMVGSGGFGEVYKA----QLRDGSVVAIKKLIR 891 Query: 329 VAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 + + QG RE++AE+ +G++ H NLV L+GYC + R+LVY Sbjct: 892 I---------TGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGEERLLVY 932
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 67.8 bits (164), Expect = 1e-11 Identities = 41/108 (37%), Positives = 62/108 (57%) Frame = +2 Query: 155 NDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVA 334 N + + PL TF L T F DS++G GGFG VYK +A+ +AI++ ++V Sbjct: 835 NVATFEKPLRKLTFAHLLEATNGFSADSMIGSGGFGDVYKAKLADG--SVVAIKKLIQV- 891 Query: 335 VKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 + QG RE++AE+ +G++ H NLV L+GYC + R+LVY Sbjct: 892 --------TGQGDREFMAEMETIGKIKHRNLVPLLGYCKIGEERLLVY 931
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 63.2 bits (152), Expect = 4e-10 Identities = 35/97 (36%), Positives = 60/97 (61%), Gaps = 1/97 (1%) Frame = +2 Query: 191 TFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK-VHDGDNSFQ 367 + + L+ +T NF D++LG GGFG VYKG +L +G ++AVK + +G + + Sbjct: 577 SIQVLRSVTNNFSSDNILGSGGFGVVYKG----ELHDG------TKIAVKRMENGVIAGK 626 Query: 368 GHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 G E+ +E+ L ++ H +LV L+GYC + + ++LVY Sbjct: 627 GFAEFKSEIAVLTKVRHRHLVTLLGYCLDGNEKLLVY 663
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 62.8 bits (151), Expect = 5e-10 Identities = 41/131 (31%), Positives = 66/131 (50%) Frame = +2 Query: 86 PSERIEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGR 265 P ++ + D+ L S R V N + + +++ + T +F Q +++G GGFG Sbjct: 703 PEKKADADEIELGS--RSVVLFHNKDSNNE----LSLDDILKSTSSFNQANIIGCGGFGL 756 Query: 266 VYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGY 445 VYK + + +VA+K GD Q RE+ AEV L + HPNLV L+GY Sbjct: 757 VYKA----------TLPDGTKVAIKRLSGDTG-QMDREFQAEVETLSRAQHPNLVHLLGY 805 Query: 446 CCEDDHRVLVY 478 C + ++L+Y Sbjct: 806 CNYKNDKLLIY 816
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does| not make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 62.4 bits (150), Expect = 6e-10 Identities = 37/97 (38%), Positives = 56/97 (57%) Frame = +2 Query: 188 FTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQ 367 FT E +++ T+ ++ +++G GGFG VY+G +++ VAVKV S Q Sbjct: 586 FTLEYIEQATEQYK--TLIGEGGFGSVYRG----------TLDDGQEVAVKVRSS-TSTQ 632 Query: 368 GHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 G RE+ E+ L + H NLV L+GYC E D ++LVY Sbjct: 633 GTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVY 669
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 61.6 bits (148), Expect = 1e-09 Identities = 36/95 (37%), Positives = 55/95 (57%) Frame = +2 Query: 194 FEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGH 373 F +L T F S++G GGFG V+K + + +AI++ +R+ S QG Sbjct: 828 FSQLIEATNGFSAASMIGHGGFGEVFKATLKDG--SSVAIKKLIRL---------SCQGD 876 Query: 374 REWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 RE++AE+ LG++ H NLV L+GYC + R+LVY Sbjct: 877 REFMAEMETLGKIKHRNLVPLLGYCKIGEERLLVY 911
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 61.2 bits (147), Expect = 1e-09 Identities = 37/97 (38%), Positives = 55/97 (56%) Frame = +2 Query: 188 FTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQ 367 FT E ++ T+ ++ +++G GGFG VY+G +++ VAVKV S Q Sbjct: 585 FTLEYIELATEKYK--TLIGEGGFGSVYRG----------TLDDGQEVAVKVRSA-TSTQ 631 Query: 368 GHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 G RE+ E+ L + H NLV L+GYC E D ++LVY Sbjct: 632 GTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVY 668
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 58.5 bits (140), Expect = 9e-09 Identities = 35/97 (36%), Positives = 57/97 (58%) Frame = +2 Query: 188 FTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQ 367 F++EEL++ T F +DS +G G F V+KG LR+G + ++ A+K D S Sbjct: 493 FSYEELEQATGGFSEDSQVGKGSFSCVFKGI----LRDGTVV--AVKRAIKASDVKKS-- 544 Query: 368 GHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 +E+ E+ L +L+H +L+ L+GYC + R+LVY Sbjct: 545 -SKEFHNELDLLSRLNHAHLLNLLGYCEDGSERLLVY 580
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 58.2 bits (139), Expect = 1e-08 Identities = 35/96 (36%), Positives = 53/96 (55%) Frame = +2 Query: 191 TFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQG 370 ++++L T +F Q +++G GGFG VYK + + +VA+K GD Q Sbjct: 723 SYDDLLDSTNSFDQANIIGCGGFGMVYKA----------TLPDGKKVAIKKLSGDCG-QI 771 Query: 371 HREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 RE+ AEV L + HPNLV L G+C + R+L+Y Sbjct: 772 EREFEAEVETLSRAQHPNLVLLRGFCFYKNDRLLIY 807
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 57.4 bits (137), Expect = 2e-08 Identities = 46/147 (31%), Positives = 73/147 (49%), Gaps = 6/147 (4%) Frame = +2 Query: 56 SVAESPKLQSPSERIEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQD 235 SV PKL+ E DS P N R+ + +F+F ELK IT NF + Sbjct: 134 SVMPMPKLE---HSCEPPDSSSPDN-------RSVESSDTRFHSFSFHELKSITNNFDEQ 183 Query: 236 SV------LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVI 397 +G GGFG VYKGCV N + +A+++ L V++ ++ + +++ E+ Sbjct: 184 PASAGGNRMGEGGFGVVYKGCVNNTI---VAVKK-LGAMVEI----STEELKQQFDQEIK 235 Query: 398 FLGQLSHPNLVKLVGYCCEDDHRVLVY 478 + H NLV+L+G+ + D+ LVY Sbjct: 236 VMATCQHENLVELLGFSSDSDNLCLVY 262
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 57.0 bits (136), Expect = 3e-08 Identities = 40/123 (32%), Positives = 62/123 (50%) Frame = +2 Query: 110 DSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVAN 289 + ++ S+ RE + PLI E + + T+NF + LG GGFG VYKG Sbjct: 492 NEMVLSSKREFSGEYKFEELELPLIEM--ETVVKATENFSSCNKLGQGGFGIVYKG---- 545 Query: 290 DLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRV 469 + + +AVK S QG E++ EV + +L H NLV+++G C E D ++ Sbjct: 546 ------RLLDGKEIAVK-RLSKTSVQGTDEFMNEVTLIARLQHINLVQVLGCCIEGDEKM 598 Query: 470 LVY 478 L+Y Sbjct: 599 LIY 601
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 56.2 bits (134), Expect = 4e-08 Identities = 36/114 (31%), Positives = 55/114 (48%) Frame = +2 Query: 137 EVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIE 316 +V A + L F+ EL+ + NF ++LG GGFG+VYKG +A Sbjct: 260 DVPAEEDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRLA---------- 309 Query: 317 EPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 + VAVK + + G ++ EV + H NL++L G+C R+LVY Sbjct: 310 DGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVY 363
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 54.7 bits (130), Expect = 1e-07 Identities = 34/96 (35%), Positives = 54/96 (56%) Frame = +2 Query: 188 FTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQ 367 +++ EL + T+ F+ + LG G G VYKG +E+ VAVK + N Q Sbjct: 524 YSYRELVKATRKFKVE--LGRGESGTVYKG----------VLEDDRHVAVKKLE--NVRQ 569 Query: 368 GHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLV 475 G + AE+ +G+++H NLV++ G+C E HR+LV Sbjct: 570 GKEVFQAELSVIGRINHMNLVRIWGFCSEGSHRLLV 605
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 49.3 bits (116), Expect = 5e-06 Identities = 29/94 (30%), Positives = 46/94 (48%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + F ++ V+G G FG VYKG R L + + VA+K Sbjct: 599 FTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKG------RLKLPSKREISVAIK 652 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 S + R++L+E +GQ HPN+++L G Sbjct: 653 TLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEG 686
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 49.3 bits (116), Expect = 5e-06 Identities = 40/140 (28%), Positives = 71/140 (50%), Gaps = 6/140 (4%) Frame = +2 Query: 77 LQSPSERIEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSV----- 241 L +P + +E+ S+ E ++L R + +F+F ELK +T NF + + Sbjct: 134 LMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFH---SFSFYELKNVTNNFDERPISVGGN 190 Query: 242 -LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +G GGFG VYKG V N +A+++ L V + + + +++ E+ + + H Sbjct: 191 KMGEGGFGVVYKGYVNNTT---VAVKK-LAAMVDI----TTEELKQQFDQEIKVMAKCQH 242 Query: 419 PNLVKLVGYCCEDDHRVLVY 478 NLV+L+G+ + D LVY Sbjct: 243 ENLVELLGFSSDGDDLCLVY 262
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 49.3 bits (116), Expect = 5e-06 Identities = 29/94 (30%), Positives = 46/94 (48%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + F ++ V+G G FG VYKG R L + + VA+K Sbjct: 516 FTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKG------RLKLPSKREISVAIK 569 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 S + R++L+E +GQ HPN+++L G Sbjct: 570 TLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEG 603
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 48.5 bits (114), Expect = 9e-06 Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 3/96 (3%) Frame = +2 Query: 200 ELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRV---AVKVHDGDNSFQG 370 E+ R T NF ++ +G GGFG VY+ + N + ++E + AVK Sbjct: 204 EISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVK---------- 253 Query: 371 HREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 + +L EV L + HPN+V GYC ++ LVY Sbjct: 254 -QSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVY 288
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 48.1 bits (113), Expect = 1e-05 Identities = 29/94 (30%), Positives = 46/94 (48%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + F ++ V+G G FG VYKG R L + + VA+K Sbjct: 598 FTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKG------RLKLPGKREIYVAIK 651 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 S + R++L+E +GQ HPN+++L G Sbjct: 652 TLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEG 685
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 48.1 bits (113), Expect = 1e-05 Identities = 29/94 (30%), Positives = 46/94 (48%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + F ++ V+G G FG VYKG R L + + VA+K Sbjct: 598 FTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKG------RLKLPGKREIYVAIK 651 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 S + R++L+E +GQ HPN+++L G Sbjct: 652 TLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEG 685
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 48.1 bits (113), Expect = 1e-05 Identities = 29/94 (30%), Positives = 46/94 (48%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + F ++ V+G G FG VYKG R L + + VA+K Sbjct: 598 FTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKG------RLKLPGKREIYVAIK 651 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 S + R++L+E +GQ HPN+++L G Sbjct: 652 TLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEG 685
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 47.4 bits (111), Expect = 2e-05 Identities = 30/117 (25%), Positives = 60/117 (51%), Gaps = 2/117 (1%) Frame = +2 Query: 134 REVEALRNDSARKNPLIAFTFEELKR--ITKNFRQDSVLGVGGFGRVYKGCVANDLREGL 307 R++ +N + L AF + K + + ++++++G GG G VY+G + N++ Sbjct: 660 RQMNKKKNQKSLAWKLTAFQKLDFKSEDVLECLKEENIIGKGGAGIVYRGSMPNNVD--- 716 Query: 308 AIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 VA+K G + + + AE+ LG++ H ++V+L+GY D +L+Y Sbjct: 717 -------VAIKRLVGRGTGRSDHGFTAEIQTLGRIRHRHIVRLLGYVANKDTNLLLY 766
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 47.0 bits (110), Expect = 3e-05 Identities = 29/83 (34%), Positives = 46/83 (55%) Frame = +2 Query: 200 ELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHRE 379 ELKR+ VLG G FG VYKG + EG ++ P VA+K+ + + + E Sbjct: 717 ELKRV-------KVLGSGAFGTVYKGIW---VPEGETVKIP--VAIKILNETTGPKANVE 764 Query: 380 WLAEVIFLGQLSHPNLVKLVGYC 448 ++ E + + + HP+LV+L+G C Sbjct: 765 FMDEALIMASMDHPHLVRLLGVC 787
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 46.6 bits (109), Expect = 3e-05 Identities = 29/83 (34%), Positives = 46/83 (55%) Frame = +2 Query: 200 ELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHRE 379 ELKR+ VLG G FG VYKG + EG ++ P VA+K+ + + + E Sbjct: 717 ELKRV-------KVLGSGAFGTVYKGIW---VPEGETVKIP--VAIKILNETTGPKANVE 764 Query: 380 WLAEVIFLGQLSHPNLVKLVGYC 448 ++ E + + + HP+LV+L+G C Sbjct: 765 FMDEALIMASVDHPHLVRLLGVC 787
>HTK16_HYDAT (P53356) Tyrosine-protein kinase HTK16 (EC 2.7.10.2)| Length = 757 Score = 46.2 bits (108), Expect = 4e-05 Identities = 28/69 (40%), Positives = 38/69 (55%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LGVG FG V KG L G + + VA+K D QG +E+L E + + QL+HP Sbjct: 490 LGVGEFGSVIKGIW---LSPG---GKEINVAMKTLHKDKMVQGEKEFLREALVMSQLNHP 543 Query: 422 NLVKLVGYC 448 +V L+G C Sbjct: 544 CIVSLLGVC 552
>DDR1_MOUSE (Q03146) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protei Length = 911 Score = 45.4 bits (106), Expect = 8e-05 Identities = 26/80 (32%), Positives = 42/80 (52%), Gaps = 7/80 (8%) Frame = +2 Query: 242 LGVGGFGRVY-------KGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 LG G FG V+ + V++D + PL VAVK+ D + ++L EV Sbjct: 614 LGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKI 673 Query: 401 LGQLSHPNLVKLVGYCCEDD 460 + +L PN+++L+G C +DD Sbjct: 674 MSRLKDPNIIRLLGVCVQDD 693
>ROS_AVISU (P00529) Tyrosine-protein kinase transforming protein ros (EC| 2.7.10.1) Length = 402 Score = 45.4 bits (106), Expect = 8e-05 Identities = 26/79 (32%), Positives = 42/79 (53%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +LG G FG VY+G + L +G RVAVK + Q E+L E + + H Sbjct: 103 LLGSGAFGEVYEGTALDILADGSGES---RVAVKTLKRGATDQEKSEFLKEAHLMSKFDH 159 Query: 419 PNLVKLVGYCCEDDHRVLV 475 P+++KL+G C ++ + L+ Sbjct: 160 PHILKLLGVCLLNEPQYLI 178
>ROS_CHICK (P08941) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2311 Score = 45.4 bits (106), Expect = 8e-05 Identities = 26/79 (32%), Positives = 42/79 (53%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +LG G FG VY+G + L +G RVAVK + Q E+L E + + H Sbjct: 1966 LLGSGAFGEVYEGTALDILADGSGES---RVAVKTLKRGATDQEKSEFLKEAHLMSKFDH 2022 Query: 419 PNLVKLVGYCCEDDHRVLV 475 P+++KL+G C ++ + L+ Sbjct: 2023 PHILKLLGVCLLNEPQYLI 2041
>FAK2_RAT (P70600) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal| adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) Length = 1009 Score = 45.1 bits (105), Expect = 1e-04 Identities = 25/73 (34%), Positives = 40/73 (54%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +LG G FG VY+G N +G E + VAVK D + ++++E + + L H Sbjct: 430 ILGEGFFGEVYEGVYTN--HKG----EKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDH 483 Query: 419 PNLVKLVGYCCED 457 P++VKL+G E+ Sbjct: 484 PHIVKLIGIIEEE 496
>FAK2_HUMAN (Q14289) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal| adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinas Length = 1009 Score = 45.1 bits (105), Expect = 1e-04 Identities = 25/73 (34%), Positives = 40/73 (54%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +LG G FG VY+G N +G E + VAVK D + ++++E + + L H Sbjct: 430 ILGEGFFGEVYEGVYTN--HKG----EKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDH 483 Query: 419 PNLVKLVGYCCED 457 P++VKL+G E+ Sbjct: 484 PHIVKLIGIIEEE 496
>ERBB3_HUMAN (P21860) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Tyrosine kinase-type cell surface receptor HER3) Length = 1342 Score = 44.7 bits (104), Expect = 1e-04 Identities = 34/117 (29%), Positives = 60/117 (51%) Frame = +2 Query: 98 IEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKG 277 +E+ +S+ P +P E + N ++A F+E + R+ VLG G FG V+KG Sbjct: 681 LERGESIEPLDPSE---------KANKVLARIFKETE-----LRKLKVLGSGVFGTVHKG 726 Query: 278 CVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYC 448 + EG +I+ P V +KV + + Q + ++ +G L H ++V+L+G C Sbjct: 727 VW---IPEGESIKIP--VCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLC 778
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 44.7 bits (104), Expect = 1e-04 Identities = 29/95 (30%), Positives = 44/95 (46%) Frame = +2 Query: 194 FEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGH 373 F E+ + T NF ++ +G GGFG VY+ + N ++E + + Sbjct: 202 FCEISQGTCNFSEELRIGEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTMVK-------- 253 Query: 374 REWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 + +L EV L + HPN+V GYC E LVY Sbjct: 254 QSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVY 288
>DDR1_PANTR (Q7YR43) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (CD167a antigen) Length = 909 Score = 44.3 bits (103), Expect = 2e-04 Identities = 26/80 (32%), Positives = 41/80 (51%), Gaps = 7/80 (8%) Frame = +2 Query: 242 LGVGGFGRVY-------KGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 LG G FG V+ + V+ D + PL VAVK+ D + ++L EV Sbjct: 612 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKI 671 Query: 401 LGQLSHPNLVKLVGYCCEDD 460 + +L PN+++L+G C +DD Sbjct: 672 MSRLKDPNIIRLLGVCVQDD 691
>ERBB3_RAT (Q62799) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) Length = 1339 Score = 44.3 bits (103), Expect = 2e-04 Identities = 34/117 (29%), Positives = 60/117 (51%) Frame = +2 Query: 98 IEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKG 277 +E+ +S+ P +P E + N ++A F+E + R+ VLG G FG V+KG Sbjct: 679 LERGESIEPLDPSE---------KANKVLARIFKETE-----LRKLKVLGSGVFGTVHKG 724 Query: 278 CVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYC 448 + EG +I+ P V +KV + + Q + ++ +G L H ++V+L+G C Sbjct: 725 IW---IPEGESIKIP--VCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLC 776
>ERBB3_MOUSE (Q61526) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Glial growth factor receptor) Length = 1339 Score = 44.3 bits (103), Expect = 2e-04 Identities = 34/117 (29%), Positives = 60/117 (51%) Frame = +2 Query: 98 IEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKG 277 +E+ +S+ P +P E + N ++A F+E + R+ VLG G FG V+KG Sbjct: 679 LERGESIEPLDPSE---------KANKVLARIFKETE-----LRKLKVLGSGVFGTVHKG 724 Query: 278 CVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYC 448 + EG +I+ P V +KV + + Q + ++ +G L H ++V+L+G C Sbjct: 725 IW---IPEGESIKIP--VCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLC 776
>DDR1_HUMAN (Q08345) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) Length = 913 Score = 44.3 bits (103), Expect = 2e-04 Identities = 26/80 (32%), Positives = 41/80 (51%), Gaps = 7/80 (8%) Frame = +2 Query: 242 LGVGGFGRVY-------KGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 LG G FG V+ + V+ D + PL VAVK+ D + ++L EV Sbjct: 616 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKI 675 Query: 401 LGQLSHPNLVKLVGYCCEDD 460 + +L PN+++L+G C +DD Sbjct: 676 MSRLKDPNIIRLLGVCVQDD 695
>XMRK_XIPMA (P13388) Melanoma receptor tyrosine-protein kinase precursor (EC| 2.7.10.1) Length = 1167 Score = 44.3 bits (103), Expect = 2e-04 Identities = 29/75 (38%), Positives = 41/75 (54%) Frame = +2 Query: 224 FRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFL 403 F++D VLG G FG VYKG D G I P VA+KV S + ++E L E + Sbjct: 710 FKKDRVLGSGAFGTVYKGLWNPD---GENIRIP--VAIKVLREATSPKVNQEVLDEAYVM 764 Query: 404 GQLSHPNLVKLVGYC 448 + HP++ +L+G C Sbjct: 765 ASVDHPHVCRLLGIC 779
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 44.3 bits (103), Expect = 2e-04 Identities = 25/74 (33%), Positives = 38/74 (51%) Frame = +2 Query: 221 NFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 N R + V+G G FG V G R L + ++VA+K S R++L+E Sbjct: 625 NIRIERVIGAGEFGEVCSG------RLRLPSKREIQVAIKSLKAGYSEHQRRDFLSEASI 678 Query: 401 LGQLSHPNLVKLVG 442 +GQ HPN+++L G Sbjct: 679 MGQFDHPNIIRLEG 692
>ROS_HUMAN (P08922) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2347 Score = 43.9 bits (102), Expect = 2e-04 Identities = 24/79 (30%), Positives = 43/79 (54%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +LG G FG VY+G + L G ++VAVK ++ Q E+L E + + +H Sbjct: 1950 LLGSGAFGEVYEGTAVDILGVGSG---EIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNH 2006 Query: 419 PNLVKLVGYCCEDDHRVLV 475 PN++K +G C ++ + ++ Sbjct: 2007 PNILKQLGVCLLNEPQYII 2025
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 43.9 bits (102), Expect = 2e-04 Identities = 32/80 (40%), Positives = 42/80 (52%), Gaps = 1/80 (1%) Frame = +2 Query: 224 FRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGH-REWLAEVIF 400 +R+ ++G G FGRVY G + D E LAI++ L QGH RE EV Sbjct: 68 WRKGELIGCGAFGRVYMG-MNLDSGELLAIKQVLIAPSSA--SKEKTQGHIRELEEEVQL 124 Query: 401 LGQLSHPNLVKLVGYCCEDD 460 L LSHPN+V+ +G E D Sbjct: 125 LKNLSHPNIVRYLGTVRESD 144
>FAK2_MOUSE (Q9QVP9) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal| adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinas Length = 1009 Score = 43.9 bits (102), Expect = 2e-04 Identities = 25/73 (34%), Positives = 40/73 (54%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +LG G FG VY+G N +G E + VAVK D + ++++E + + L H Sbjct: 430 ILGEGFFGEVYEGVYTN--HKG----EKINVAVKTCKKDCTQDNKEKFMSEAVIMKNLDH 483 Query: 419 PNLVKLVGYCCED 457 P++VKL+G E+ Sbjct: 484 PHIVKLIGIIEEE 496
>ERBB3_PONPY (Q5RB22) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) Length = 1342 Score = 43.5 bits (101), Expect = 3e-04 Identities = 33/117 (28%), Positives = 60/117 (51%) Frame = +2 Query: 98 IEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKG 277 +E+ +S+ P +P E + N ++A F+E + ++ VLG G FG V+KG Sbjct: 681 LERGESIEPLDPSE---------KANKVLARIFKETE-----LKKLKVLGSGVFGTVHKG 726 Query: 278 CVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYC 448 + EG +I+ P V +KV + + Q + ++ +G L H ++V+L+G C Sbjct: 727 VW---IPEGESIKIP--VCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLC 778
>ROR2_DROME (Q9V6K3) Tyrosine-protein kinase transmembrane receptor Ror2| precursor (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase) Length = 724 Score = 43.5 bits (101), Expect = 3e-04 Identities = 25/69 (36%), Positives = 37/69 (53%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G FGRV++ + + +E L VAVK+ D S Q ++ E L + HP Sbjct: 447 LGQGAFGRVFQARAPGLVPD----QEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHP 502 Query: 422 NLVKLVGYC 448 N+V+L+G C Sbjct: 503 NIVRLLGVC 511
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 43.5 bits (101), Expect = 3e-04 Identities = 26/72 (36%), Positives = 36/72 (50%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +LG G FG VYKG +++ VAVK D + ++L E L Q H Sbjct: 568 LLGKGNFGEVYKG----------TLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDH 617 Query: 419 PNLVKLVGYCCE 454 PN+VKL+G C + Sbjct: 618 PNIVKLIGVCTQ 629
>MERTK_HUMAN (Q12866) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 999 Score = 43.1 bits (100), Expect = 4e-04 Identities = 29/75 (38%), Positives = 43/75 (57%), Gaps = 3/75 (4%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHRE---WLAEVIFLGQ 409 +LG G FG V +G + + +G + L+VAVK DNS HRE +L+E + Sbjct: 592 ILGEGEFGSVMEGNLKQE--DGTS----LKVAVKTMKLDNS--SHREIEEFLSEAACMKD 643 Query: 410 LSHPNLVKLVGYCCE 454 SHPN+++L+G C E Sbjct: 644 FSHPNVIRLLGVCIE 658
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 43.1 bits (100), Expect = 4e-04 Identities = 26/72 (36%), Positives = 36/72 (50%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +LG G FG VYKG +++ VAVK D + ++L E L Q H Sbjct: 69 LLGKGNFGEVYKG----------TLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDH 118 Query: 419 PNLVKLVGYCCE 454 PN+VKL+G C + Sbjct: 119 PNIVKLIGVCTQ 130
>EGFR_DROME (P04412) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Egfr) (Gurken receptor) (Protein torpedo) (Drosophila relative of ERBB) Length = 1426 Score = 43.1 bits (100), Expect = 4e-04 Identities = 30/82 (36%), Positives = 42/82 (51%), Gaps = 2/82 (2%) Frame = +2 Query: 209 RITKN--FRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREW 382 RI K+ R+ VLG+G FGRVYKG + EG ++ P VA+K + E+ Sbjct: 931 RIVKDAELRKGGVLGMGAFGRVYKGVW---VPEGENVKIP--VAIKELLKSTGAESSEEF 985 Query: 383 LAEVIFLGQLSHPNLVKLVGYC 448 L E + H NL+KL+ C Sbjct: 986 LREAYIMASEEHVNLLKLLAVC 1007
>RYK_AVIR3 (P33497) Tyrosine-protein kinase transforming protein RYK (EC| 2.7.10.1) Length = 442 Score = 42.7 bits (99), Expect = 5e-04 Identities = 29/73 (39%), Positives = 40/73 (54%), Gaps = 1/73 (1%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDN-SFQGHREWLAEVIFLGQLS 415 VLG G FG V +G ++ EG P +VAVK DN S + E+L+E + Sbjct: 50 VLGEGEFGSVMEGRLSQP--EGT----PQKVAVKTMKLDNFSHREIEEFLSEAACIKDFD 103 Query: 416 HPNLVKLVGYCCE 454 HPN++KL+G C E Sbjct: 104 HPNVIKLLGVCIE 116
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 42.7 bits (99), Expect = 5e-04 Identities = 26/80 (32%), Positives = 40/80 (50%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 V+G G FGRV+ G A+ +++ E VAVK G S R++ E L + H Sbjct: 509 VIGEGAFGRVFLGTCAHLIQKN----EFAIVAVKTLKGSCSDSLKRDFEREAEMLATIEH 564 Query: 419 PNLVKLVGYCCEDDHRVLVY 478 N+V G C E D ++++ Sbjct: 565 ANIVTFYGVCTESDQWMMIF 584
>LET23_CAEEL (P24348) Receptor tyrosine-protein kinase let-23 precursor (EC| 2.7.10.1) (Lethal protein 23) Length = 1367 Score = 42.7 bits (99), Expect = 5e-04 Identities = 27/76 (35%), Positives = 37/76 (48%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 D LG G FG V+ G + + I VA+KV D S E L E + +L Sbjct: 932 DKKLGAGAFGTVFAGIYYPKRAKNVKIP----VAIKVFQTDQSQTD--EMLEEATNMFRL 985 Query: 413 SHPNLVKLVGYCCEDD 460 H NL+K++G+C DD Sbjct: 986 RHDNLLKIIGFCMHDD 1001
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 42.7 bits (99), Expect = 5e-04 Identities = 24/74 (32%), Positives = 37/74 (50%) Frame = +2 Query: 221 NFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 N D V+G G FG V G R L ++ + VA+K + + R++L E Sbjct: 620 NISIDKVVGAGEFGEVCSG------RLKLPSKKEISVAIKTLKAGYTEKQRRDFLGEASI 673 Query: 401 LGQLSHPNLVKLVG 442 +GQ HPN+++L G Sbjct: 674 MGQFDHPNIIRLEG 687
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 42.4 bits (98), Expect = 6e-04 Identities = 25/85 (29%), Positives = 41/85 (48%) Frame = +2 Query: 221 NFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 N D V+G G FG V G R L ++ + VA+K + + R++L E Sbjct: 620 NISIDKVVGAGEFGEVCSG------RLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASI 673 Query: 401 LGQLSHPNLVKLVGYCCEDDHRVLV 475 +GQ HPN+++L G + ++V Sbjct: 674 MGQFDHPNIIRLEGVVTKSKPEMIV 698
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 42.4 bits (98), Expect = 6e-04 Identities = 28/95 (29%), Positives = 46/95 (48%), Gaps = 10/95 (10%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCV-ANDLREGLAIEEPLRVAV 337 FT+E+ + F ++ V+G G FG V +G + A +E VA+ Sbjct: 594 FTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESC-------VAI 646 Query: 338 KVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 K G + + RE+L+E +GQ HPN+++L G Sbjct: 647 KTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEG 681
>EPHB4_HUMAN (P54760) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HTK) Length = 987 Score = 42.4 bits (98), Expect = 6e-04 Identities = 28/95 (29%), Positives = 46/95 (48%), Gaps = 10/95 (10%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCV-ANDLREGLAIEEPLRVAV 337 FT+E+ + F ++ V+G G FG V +G + A +E VA+ Sbjct: 594 FTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESC-------VAI 646 Query: 338 KVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 K G + + RE+L+E +GQ HPN+++L G Sbjct: 647 KTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEG 681
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 41.6 bits (96), Expect = 0.001 Identities = 24/74 (32%), Positives = 37/74 (50%) Frame = +2 Query: 221 NFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 N D V+G G FG V G R L ++ + VA+K + + R++L E Sbjct: 620 NISIDKVVGAGEFGEVCSG------RLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASI 673 Query: 401 LGQLSHPNLVKLVG 442 +GQ HPN+++L G Sbjct: 674 MGQFDHPNIIRLEG 687
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 41.6 bits (96), Expect = 0.001 Identities = 24/74 (32%), Positives = 37/74 (50%) Frame = +2 Query: 221 NFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 N D V+G G FG V G R L ++ + VA+K + + R++L E Sbjct: 621 NIAIDKVVGAGEFGEVCSG------RLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASI 674 Query: 401 LGQLSHPNLVKLVG 442 +GQ HPN+++L G Sbjct: 675 MGQFDHPNIIRLEG 688
>DDR1_RAT (Q63474) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein- Length = 910 Score = 41.6 bits (96), Expect = 0.001 Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 7/80 (8%) Frame = +2 Query: 242 LGVGGFGRVY-------KGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 LG G FG V+ + V +D + PL VAVK+ D + ++L EV Sbjct: 613 LGEGQFGEVHLCEVEDPQDLVTSDFPISVQKGHPLLVAVKILRPDATKNARNDFLKEVKI 672 Query: 401 LGQLSHPNLVKLVGYCCEDD 460 + +L N+++L+G C +DD Sbjct: 673 MSRLKDLNIIRLLGVCVQDD 692
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 41.6 bits (96), Expect = 0.001 Identities = 28/89 (31%), Positives = 41/89 (46%), Gaps = 3/89 (3%) Frame = +2 Query: 218 KNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKV--HDGDNSFQGHREWL-A 388 + R + V+G+GGFG+VY+G +L VAVK D D E + Sbjct: 115 QELRLEEVIGIGGFGKVYRGSWRGEL-----------VAVKAARQDPDEDISVTAESVRQ 163 Query: 389 EVIFLGQLSHPNLVKLVGYCCEDDHRVLV 475 E L+HPN++ L C E+ + LV Sbjct: 164 EARLFAMLAHPNIIALKAVCLEEPNLCLV 192
>7LESS_DROVI (P20806) Protein sevenless (EC 2.7.10.1)| Length = 2594 Score = 41.6 bits (96), Expect = 0.001 Identities = 27/79 (34%), Positives = 39/79 (49%), Gaps = 1/79 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK-VHDGDNSFQGHREWLAEVIFLGQLSH 418 LG G FG VY+G + + +P RVA+K + G + F E L E + H Sbjct: 2230 LGSGAFGEVYEGQLQAEDEA-----QPQRVAIKSLRKGASEFA---ELLQEAQLMSNFKH 2281 Query: 419 PNLVKLVGYCCEDDHRVLV 475 N+V L+G CC+ D L+ Sbjct: 2282 ENIVCLIGICCDTDSISLI 2300
>EPA4B_XENLA (Q91694) Ephrin type-A receptor 4-B precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor PAG) (Pagliaccio) Length = 985 Score = 41.2 bits (95), Expect = 0.001 Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + + F ++ V+GVG FG V G R + + + VA+K Sbjct: 599 FTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSG------RLKVPGKREIYVAIK 652 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L+E +GQ HPN++ L G Sbjct: 653 TLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEG 686
>EPA4A_XENLA (Q91845) Ephrin type-A receptor 4-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK-1) (xSEK-1) Length = 986 Score = 41.2 bits (95), Expect = 0.001 Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + + F ++ V+GVG FG V G R + + + VA+K Sbjct: 599 FTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSG------RLKVPGKREIYVAIK 652 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L+E +GQ HPN++ L G Sbjct: 653 TLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEG 686
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 41.2 bits (95), Expect = 0.001 Identities = 28/80 (35%), Positives = 44/80 (55%) Frame = +2 Query: 221 NFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 ++R+ ++G G FG VY G + D E LA+++ L +A + + +E EV Sbjct: 68 SWRKGQLIGRGAFGTVYMG-MNLDSGELLAVKQVL-IAANFASKEKTQAHIQELEEEVKL 125 Query: 401 LGQLSHPNLVKLVGYCCEDD 460 L LSHPN+V+ +G EDD Sbjct: 126 LKNLSHPNIVRYLGTVREDD 145
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 41.2 bits (95), Expect = 0.001 Identities = 27/94 (28%), Positives = 46/94 (48%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ ++F ++ V+G G FG V +G L++ E+ VA+K Sbjct: 588 FTYEDPNEAVRDFAKEIDISCVKIEEVIGAGEFGEVCRG----KLKQAGRREQ--FVAIK 641 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + Q R++L E +GQ HPN+++L G Sbjct: 642 TLKAGYTEQQRRDFLGEASIMGQFDHPNIIRLEG 675
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 41.2 bits (95), Expect = 0.001 Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 3/101 (2%) Frame = +2 Query: 185 AFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSF 364 + +F+ + T+NF +D ++G G VY+ + N L AVK+ + Sbjct: 152 SISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQN-----------LTYAVKLFKQEKKM 200 Query: 365 QGHREW---LAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 Q + W L+E+ L HPN+++L Y E + L+Y Sbjct: 201 QCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIY 241
>SSK22_YEAST (P25390) Serine/threonine-protein kinase SSK22 (EC 2.7.11.1) (MAP| kinase kinase kinase SSK22) (Suppressor of sensor kinase 22) Length = 1331 Score = 41.2 bits (95), Expect = 0.001 Identities = 31/119 (26%), Positives = 58/119 (48%), Gaps = 2/119 (1%) Frame = +2 Query: 92 ERIEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVY 271 E I+ + + NPR++ + + + + N + L ++ +++ S +G G FG+VY Sbjct: 990 EAIKTLEKTMKRNPRQMGKVLDATDQGNKYLLSLASSLSNVSMRWQKRSFIGGGTFGQVY 1049 Query: 272 KGCVANDLREG--LAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 A +L G LA++E +K+HD + E+ L L+HPN+V+ G Sbjct: 1050 S---AINLENGEILAVKE-----IKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYG 1100
>ALK_HUMAN (Q9UM73) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1620 Score = 40.8 bits (94), Expect = 0.002 Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 1/85 (1%) Frame = +2 Query: 191 TFEELKRIT-KNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQ 367 + +LK + KN LG G FG VY+G V+ + PL+VAVK S Q Sbjct: 1104 SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPND----PSPLQVAVKTLPEVCSEQ 1159 Query: 368 GHREWLAEVIFLGQLSHPNLVKLVG 442 ++L E + + + +H N+V+ +G Sbjct: 1160 DELDFLMEALIISKFNHQNIVRCIG 1184
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 40.8 bits (94), Expect = 0.002 Identities = 23/70 (32%), Positives = 35/70 (50%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + V+G G FG V GC+ L + L VA+K + + R++L E +GQ Sbjct: 517 ERVIGAGEFGEVCSGCLK------LPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQF 570 Query: 413 SHPNLVKLVG 442 HPN++ L G Sbjct: 571 DHPNIIHLEG 580
>ALK_MOUSE (P97793) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1621 Score = 40.8 bits (94), Expect = 0.002 Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 1/85 (1%) Frame = +2 Query: 191 TFEELKRIT-KNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQ 367 + +LK + KN LG G FG VY+G V+ + PL+VAVK S Q Sbjct: 1108 SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPND----PSPLQVAVKTLPEVCSEQ 1163 Query: 368 GHREWLAEVIFLGQLSHPNLVKLVG 442 ++L E + + + +H N+V+ +G Sbjct: 1164 DELDFLMEALIISKFNHQNIVRCIG 1188
>EPHA4_MOUSE (Q03137) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (MPK-3) Length = 986 Score = 40.8 bits (94), Expect = 0.002 Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + + F ++ V+GVG FG V G R + + + VA+K Sbjct: 600 FTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSG------RLKVPGKREICVAIK 653 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L+E +GQ HPN++ L G Sbjct: 654 TLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEG 687
>EPHA4_HUMAN (P54764) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8) Length = 986 Score = 40.8 bits (94), Expect = 0.002 Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + + F ++ V+GVG FG V G R + + + VA+K Sbjct: 600 FTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSG------RLKVPGKREICVAIK 653 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L+E +GQ HPN++ L G Sbjct: 654 TLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEG 687
>EPHA4_CHICK (Q07496) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK8) Length = 986 Score = 40.8 bits (94), Expect = 0.002 Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + + F ++ V+GVG FG V G R + + + VA+K Sbjct: 600 FTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSG------RLKVPGKREICVAIK 653 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L+E +GQ HPN++ L G Sbjct: 654 TLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEG 687
>EGFR_HUMAN (P00533) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Receptor tyrosine-protein kinase ErbB-1) Length = 1210 Score = 40.4 bits (93), Expect = 0.002 Identities = 29/86 (33%), Positives = 46/86 (53%), Gaps = 2/86 (2%) Frame = +2 Query: 197 EELKRITKN--FRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQG 370 + L RI K F++ VLG G FG VYKG + EG ++ P VA+K S + Sbjct: 701 QALLRILKETEFKKIKVLGSGAFGTVYKGLW---IPEGEKVKIP--VAIKELREATSPKA 755 Query: 371 HREWLAEVIFLGQLSHPNLVKLVGYC 448 ++E L E + + +P++ +L+G C Sbjct: 756 NKEILDEAYVMASVDNPHVCRLLGIC 781
>7LESS_DROME (P13368) Protein sevenless (EC 2.7.10.1)| Length = 2554 Score = 40.4 bits (93), Expect = 0.002 Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 1/79 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK-VHDGDNSFQGHREWLAEVIFLGQLSH 418 LG G FG VY+G + + EEP RVA+K + G + F E L E + H Sbjct: 2215 LGSGAFGEVYEGQLKTE-----DSEEPQRVAIKSLRKGASEFA---ELLQEAQLMSNFKH 2266 Query: 419 PNLVKLVGYCCEDDHRVLV 475 N+V LVG C + + L+ Sbjct: 2267 ENIVCLVGICFDTESISLI 2285
>LTK_MOUSE (P08923) Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1)| Length = 888 Score = 40.4 bits (93), Expect = 0.002 Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 1/79 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEE-PLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 LG G FG VY+G V GL + PL VA+K S Q ++L E + + + SH Sbjct: 512 LGHGAFGEVYEGLVT-----GLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFSH 566 Query: 419 PNLVKLVGYCCEDDHRVLV 475 N+V+ VG R+++ Sbjct: 567 QNIVRCVGLSFRSAPRLIL 585
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 40.4 bits (93), Expect = 0.002 Identities = 34/126 (26%), Positives = 51/126 (40%), Gaps = 6/126 (4%) Frame = +2 Query: 116 LLPSN---PREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVA 286 + PSN PR + R ++P + L+ + ++G+GGFG+VY+ Sbjct: 105 IFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWI 164 Query: 287 NDLREGLAIEEPLRVAVKV--HDGDNSF-QGHREWLAEVIFLGQLSHPNLVKLVGYCCED 457 D VAVK HD D Q E L HPN++ L G C ++ Sbjct: 165 GD-----------EVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKE 213 Query: 458 DHRVLV 475 + LV Sbjct: 214 PNLCLV 219
>EPHA6_RAT (P54758) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 40.4 bits (93), Expect = 0.002 Identities = 26/91 (28%), Positives = 43/91 (47%) Frame = +2 Query: 170 KNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHD 349 ++P +A E + R + V+G G FG V G R + + VA+K Sbjct: 612 EDPSLAVHEFEKEIDPSRIRIERVIGAGEFGEVCSG------RLKTPGKREIPVAIKTLK 665 Query: 350 GDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 G + + R++L E +GQ HPN+++L G Sbjct: 666 GGHMDRQRRDFLREASIMGQFDHPNIIRLEG 696
>RET_MOUSE (P35546) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1115 Score = 40.4 bits (93), Expect = 0.002 Identities = 41/150 (27%), Positives = 63/150 (42%), Gaps = 2/150 (1%) Frame = +2 Query: 32 QGF-FHATKSVAESPKLQSPSERIEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELK 208 QGF + S P L S ++ D +P +P+ + RKN ++ T Sbjct: 682 QGFPISYSSSGTRRPSLDSTENQVPVDSFKIPEDPKW------EFPRKNLVLGKT----- 730 Query: 209 RITKNFRQDSVLGVGGFGRVYKGCVAN-DLREGLAIEEPLRVAVKVHDGDNSFQGHREWL 385 LG G FG+V K R G VAVK+ + S R+ L Sbjct: 731 -----------LGEGEFGKVVKATAFRLKGRAGYTT-----VAVKMLKENASQSELRDLL 774 Query: 386 AEVIFLGQLSHPNLVKLVGYCCEDDHRVLV 475 +E L Q++HP+++KL G C +D +L+ Sbjct: 775 SEFNLLKQVNHPHVIKLYGACSQDGPLLLI 804
>EPHB3_MOUSE (P54754) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4) Length = 993 Score = 40.0 bits (92), Expect = 0.003 Identities = 26/94 (27%), Positives = 44/94 (46%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + F ++ V+G G FG V +G R L + VA+K Sbjct: 607 FTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRG------RLKLPGRREVFVAIK 660 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L+E +GQ HPN+++L G Sbjct: 661 TLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEG 694
>EPHB3_CHICK (Q07498) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor CEK10) (Fragment) Length = 988 Score = 40.0 bits (92), Expect = 0.003 Identities = 35/141 (24%), Positives = 60/141 (42%), Gaps = 11/141 (7%) Frame = +2 Query: 53 KSVAESPKLQSPSERIEKDDSLLPSNPREVEALRN--DSARKNPLIAFTFEELKRITKNF 226 K + L SP R +++ + +P E L+ K + FT+E+ + F Sbjct: 559 KGMVTEQLLSSPLGRKQRNST----DPEYTEKLQQYVTPGMKVYIDPFTYEDPNEAVREF 614 Query: 227 RQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHRE 379 ++ V+G G FG V +G R L + VA+K + + R+ Sbjct: 615 AKEIDISCVKIEEVIGAGEFGEVCRG------RLKLPGRREIFVAIKTLKVGYTERQRRD 668 Query: 380 WLAEVIFLGQLSHPNLVKLVG 442 +L+E +GQ HPN++ L G Sbjct: 669 FLSEASIMGQFDHPNIIHLEG 689
>EPHA6_MOUSE (Q62413) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 40.0 bits (92), Expect = 0.003 Identities = 23/72 (31%), Positives = 36/72 (50%) Frame = +2 Query: 227 RQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLG 406 R + V+G G FG V G R + + VA+K G + + R++L E +G Sbjct: 631 RIERVIGAGEFGEVCSG------RLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMG 684 Query: 407 QLSHPNLVKLVG 442 Q HPN+++L G Sbjct: 685 QFDHPNIIRLEG 696
>EPHA6_HUMAN (Q9UF33) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 40.0 bits (92), Expect = 0.003 Identities = 23/72 (31%), Positives = 36/72 (50%) Frame = +2 Query: 227 RQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLG 406 R + V+G G FG V G R + + VA+K G + + R++L E +G Sbjct: 631 RIERVIGAGEFGEVCSG------RLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMG 684 Query: 407 QLSHPNLVKLVG 442 Q HPN+++L G Sbjct: 685 QFDHPNIIRLEG 696
>DDR2_HUMAN (Q16832) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 855 Score = 40.0 bits (92), Expect = 0.003 Identities = 27/95 (28%), Positives = 44/95 (46%), Gaps = 7/95 (7%) Frame = +2 Query: 197 EELKRITKNFRQDSVLGVGGFGRVYKGCVAN-------DLREGLAIEEPLRVAVKVHDGD 355 EE R F++ LG G FG V+ V D ++ +P+ VAVK+ D Sbjct: 556 EEFPRKLLTFKEK--LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRAD 613 Query: 356 NSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDD 460 + ++L E+ + +L PN++ L+ C DD Sbjct: 614 ANKNARNDFLKEIKIMSRLKDPNIIHLLSVCITDD 648
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 39.7 bits (91), Expect = 0.004 Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 5/105 (4%) Frame = +2 Query: 179 LIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDG-- 352 L+ + EL+ T + D+ LG GGFG VY+G + L VA+KV + Sbjct: 198 LLEIDYAELENATDGWSPDNRLGQGGFGDVYRG-----------KWKQLDVAIKVMNYRS 246 Query: 353 ---DNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 D ++ E+ +L + H N++ L GY + LVY Sbjct: 247 PNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVY 291
>EGFR_MOUSE (Q01279) Epidermal growth factor receptor precursor (EC 2.7.10.1)| Length = 1210 Score = 39.3 bits (90), Expect = 0.005 Identities = 25/75 (33%), Positives = 41/75 (54%) Frame = +2 Query: 224 FRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFL 403 F++ VLG G FG VYKG + EG ++ P VA+K S + ++E L E + Sbjct: 714 FKKIKVLGSGAFGTVYKGLW---IPEGEKVKIP--VAIKELREATSPKANKEILDEAYVM 768 Query: 404 GQLSHPNLVKLVGYC 448 + +P++ +L+G C Sbjct: 769 ASVDNPHVCRLLGIC 783
>ERBB_ALV (P00534) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 634 Score = 39.3 bits (90), Expect = 0.005 Identities = 25/75 (33%), Positives = 41/75 (54%) Frame = +2 Query: 224 FRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFL 403 F++ VLG G FG VYKG + EG ++ P VA+K S + ++E L E + Sbjct: 132 FKKVKVLGSGAFGTVYKGLW---IPEGEKVKIP--VAIKELREATSPKANKEILDEAYVM 186 Query: 404 GQLSHPNLVKLVGYC 448 + +P++ +L+G C Sbjct: 187 ASVDNPHVCRLLGIC 201
>EPHB3_HUMAN (P54753) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HEK-2) Length = 998 Score = 39.3 bits (90), Expect = 0.005 Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + F ++ V+G G FG V +G + R + VA+K Sbjct: 612 FTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVF------VAIK 665 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L+E +GQ HPN+++L G Sbjct: 666 TLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEG 699
>MERTK_RAT (P57097) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 994 Score = 39.3 bits (90), Expect = 0.005 Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 1/73 (1%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDN-SFQGHREWLAEVIFLGQLS 415 VLG G FG V +G + + +G + +VAVK DN S + E+L+E + + Sbjct: 587 VLGEGEFGSVMEGNLKQE--DGTS----QKVAVKTMKLDNFSLREIEEFLSEAACMKDFN 640 Query: 416 HPNLVKLVGYCCE 454 HPN+++L+G C E Sbjct: 641 HPNVIRLLGVCIE 653
>ERBB_AVIER (P00535) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 604 Score = 38.9 bits (89), Expect = 0.007 Identities = 24/75 (32%), Positives = 41/75 (54%) Frame = +2 Query: 224 FRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFL 403 F++ VLG G FG +YKG + EG ++ P VA+K S + ++E L E + Sbjct: 132 FKKVKVLGSGAFGTIYKGLW---IPEGEKVKIP--VAIKELREATSPKANKEILDEAYVM 186 Query: 404 GQLSHPNLVKLVGYC 448 + +P++ +L+G C Sbjct: 187 ASVDNPHVCRLLGIC 201
>MERTK_MOUSE (Q60805) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 994 Score = 38.9 bits (89), Expect = 0.007 Identities = 26/73 (35%), Positives = 40/73 (54%), Gaps = 1/73 (1%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGH-REWLAEVIFLGQLS 415 VLG G FG V +G + + +G + +VAVK DN Q E+L+E + + Sbjct: 587 VLGEGEFGSVMEGNLKQE--DGTS----QKVAVKTMKLDNFSQREIEEFLSEAACMKDFN 640 Query: 416 HPNLVKLVGYCCE 454 HPN+++L+G C E Sbjct: 641 HPNVIRLLGVCIE 653
>DDR2_MOUSE (Q62371) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 854 Score = 38.9 bits (89), Expect = 0.007 Identities = 26/95 (27%), Positives = 45/95 (47%), Gaps = 7/95 (7%) Frame = +2 Query: 197 EELKRITKNFRQDSVLGVGGFGRVYKGCVAN-------DLREGLAIEEPLRVAVKVHDGD 355 EE R F++ LG G FG V+ V D ++ +P+ VAVK+ D Sbjct: 556 EEFPRKLLAFKEK--LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRAD 613 Query: 356 NSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDD 460 + ++L E+ + +L PN+++L+ C +D Sbjct: 614 ANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITED 648
>ERBB_AVIEU (P11273) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 540 Score = 38.9 bits (89), Expect = 0.007 Identities = 25/75 (33%), Positives = 40/75 (53%) Frame = +2 Query: 224 FRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFL 403 F++ VLG G FG VYKG + EG + P VA+K S + ++E L E + Sbjct: 132 FKKVKVLGFGAFGTVYKGLW---IPEGEKVTIP--VAIKELREATSPKANKEILDEAYVM 186 Query: 404 GQLSHPNLVKLVGYC 448 + +P++ +L+G C Sbjct: 187 ASVDNPHVCRLLGIC 201
>TLK2_MOUSE (O55047) Serine/threonine-protein kinase tousled-like 2 (EC| 2.7.11.1) (Tousled-like kinase 2) Length = 718 Score = 38.5 bits (88), Expect = 0.009 Identities = 37/150 (24%), Positives = 65/150 (43%), Gaps = 6/150 (4%) Frame = +2 Query: 14 RESVLQQGFFHATKSVAESPKLQSPSERIEKDDSLLPSNPREVEALRNDSARKNPLIAFT 193 +E + + H K AE +Q+ ER+E+ +L + RE++ + N+ + Sbjct: 351 QEEIFKLRLGHLKKEEAE---IQAELERLERVRNL---HIRELKRIHNEDNSQ------- 397 Query: 194 FEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQG- 370 F++ + + +LG GGF VYK + E VAVK+H + +++ Sbjct: 398 FKDHPTLNDRYLLLHLLGRGGFSEVYKA---------FDLTEQRYVAVKIHQLNKNWRDE 448 Query: 371 -----HREWLAEVIFLGQLSHPNLVKLVGY 445 H+ E +L HP +VKL Y Sbjct: 449 KKENYHKHACREYRIHKELDHPRIVKLYDY 478
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 38.5 bits (88), Expect = 0.009 Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + F ++ V+G G FG V G + L + + VA+K Sbjct: 601 FTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLK------LPGKREIFVAIK 654 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L+E +GQ HPN++ L G Sbjct: 655 TLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEG 688
>RET_HUMAN (P07949) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1114 Score = 38.5 bits (88), Expect = 0.009 Identities = 29/87 (33%), Positives = 43/87 (49%), Gaps = 1/87 (1%) Frame = +2 Query: 218 KNFRQDSVLGVGGFGRVYKGCVAN-DLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEV 394 KN LG G FG+V K + R G VAVK+ + S R+ L+E Sbjct: 722 KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT-----VAVKMLKENASPSELRDLLSEF 776 Query: 395 IFLGQLSHPNLVKLVGYCCEDDHRVLV 475 L Q++HP+++KL G C +D +L+ Sbjct: 777 NVLKQVNHPHVIKLYGACSQDGPLLLI 803
>ERBB2_MESAU (Q60553) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) Length = 1254 Score = 38.5 bits (88), Expect = 0.009 Identities = 27/74 (36%), Positives = 39/74 (52%) Frame = +2 Query: 227 RQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLG 406 R+ VLG G FG VYKG D G ++ P VA+KV + S + ++E L E + Sbjct: 721 RKVKVLGSGAFGTVYKGIWIPD---GENVKIP--VAIKVLRENTSPKANKEILDEAYVMA 775 Query: 407 QLSHPNLVKLVGYC 448 L P + +L+G C Sbjct: 776 GLGSPYVSRLLGIC 789
>TLK2_HUMAN (Q86UE8) Serine/threonine-protein kinase tousled-like 2 (EC| 2.7.11.1) (Tousled-like kinase 2) (PKU-alpha) Length = 772 Score = 38.5 bits (88), Expect = 0.009 Identities = 37/150 (24%), Positives = 65/150 (43%), Gaps = 6/150 (4%) Frame = +2 Query: 14 RESVLQQGFFHATKSVAESPKLQSPSERIEKDDSLLPSNPREVEALRNDSARKNPLIAFT 193 +E + + H K AE +Q+ ER+E+ +L + RE++ + N+ + Sbjct: 405 QEEIFKLRLGHLKKEEAE---IQAELERLERVRNL---HIRELKRIHNEDNSQ------- 451 Query: 194 FEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQG- 370 F++ + + +LG GGF VYK + E VAVK+H + +++ Sbjct: 452 FKDHPTLNDRYLLLHLLGRGGFSEVYKA---------FDLTEQRYVAVKIHQLNKNWRDE 502 Query: 371 -----HREWLAEVIFLGQLSHPNLVKLVGY 445 H+ E +L HP +VKL Y Sbjct: 503 KKENYHKHACREYRIHKELDHPRIVKLYDY 532
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 38.5 bits (88), Expect = 0.009 Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + F ++ V+G G FG V G + L + + VA+K Sbjct: 608 FTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLK------LPGKREIFVAIK 661 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L+E +GQ HPN++ L G Sbjct: 662 TLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEG 695
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 38.5 bits (88), Expect = 0.009 Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + F ++ V+G G FG V G + L + + VA+K Sbjct: 600 FTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLK------LPGKREIFVAIK 653 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L+E +GQ HPN++ L G Sbjct: 654 TLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEG 687
>CDC5_YEAST (P32562) Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC| 2.7.11.21) Length = 705 Score = 38.5 bits (88), Expect = 0.009 Identities = 25/91 (27%), Positives = 47/91 (51%) Frame = +2 Query: 203 LKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREW 382 +K K++ + LG GGF R ++ + +D E A + + ++K S + ++ Sbjct: 75 IKTRGKDYHRGHFLGEGGFARCFQ--IKDDSGEIFAAKTVAKASIK------SEKTRKKL 126 Query: 383 LAEVIFLGQLSHPNLVKLVGYCCEDDHRVLV 475 L+E+ +SHPN+V+ + C EDD V + Sbjct: 127 LSEIQIHKSMSHPNIVQFID-CFEDDSNVYI 156
>TLK1_MOUSE (Q8C0V0) Serine/threonine-protein kinase tousled-like 1 (EC| 2.7.11.1) (Tousled-like kinase 1) Length = 766 Score = 38.5 bits (88), Expect = 0.009 Identities = 37/150 (24%), Positives = 65/150 (43%), Gaps = 6/150 (4%) Frame = +2 Query: 14 RESVLQQGFFHATKSVAESPKLQSPSERIEKDDSLLPSNPREVEALRNDSARKNPLIAFT 193 +E + + H K AE +Q+ ER+E+ +L + RE++ + N+ + Sbjct: 399 QEEIFKLRLGHLKKEEAE---IQAELERLERVRNL---HIRELKRINNEDNSQ------- 445 Query: 194 FEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQG- 370 F++ + + + +LG GGF VYK + E AVK+H + S++ Sbjct: 446 FKDHPTLNERYLLLHLLGRGGFSEVYK---------AFDLYEQRYAAVKIHQLNKSWRDE 496 Query: 371 -----HREWLAEVIFLGQLSHPNLVKLVGY 445 H+ E +L HP +VKL Y Sbjct: 497 KKENYHKHACREYRIHKELDHPRIVKLYDY 526
>TLK1_HUMAN (Q9UKI8) Serine/threonine-protein kinase tousled-like 1 (EC| 2.7.11.1) (Tousled-like kinase 1) (PKU-beta) Length = 766 Score = 38.5 bits (88), Expect = 0.009 Identities = 37/150 (24%), Positives = 65/150 (43%), Gaps = 6/150 (4%) Frame = +2 Query: 14 RESVLQQGFFHATKSVAESPKLQSPSERIEKDDSLLPSNPREVEALRNDSARKNPLIAFT 193 +E + + H K AE +Q+ ER+E+ +L + RE++ + N+ + Sbjct: 399 QEEIFKLRLGHLKKEEAE---IQAELERLERVRNL---HIRELKRINNEDNSQ------- 445 Query: 194 FEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQG- 370 F++ + + + +LG GGF VYK + E AVK+H + S++ Sbjct: 446 FKDHPTLNERYLLLHLLGRGGFSEVYK---------AFDLYEQRYAAVKIHQLNKSWRDE 496 Query: 371 -----HREWLAEVIFLGQLSHPNLVKLVGY 445 H+ E +L HP +VKL Y Sbjct: 497 KKENYHKHACREYRIHKELDHPRIVKLYDY 526
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 38.5 bits (88), Expect = 0.009 Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ + F ++ V+G G FG V G + L + + VA+K Sbjct: 618 FTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLK------LPGKREIFVAIK 671 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L+E +GQ HPN++ L G Sbjct: 672 TLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEG 705
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 38.5 bits (88), Expect = 0.009 Identities = 41/128 (32%), Positives = 52/128 (40%), Gaps = 2/128 (1%) Frame = +2 Query: 80 QSPSERIEKDD--SLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVG 253 Q PS R D L P N +V + DS +P + KR K R LG G Sbjct: 855 QRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFH-----KRYLKKIRD---LGEG 906 Query: 254 GFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVK 433 FG+V C + +G VAVK D Q W E+ L L H +++K Sbjct: 907 HFGKVSLYCY-DPTNDGTGE----MVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIK 961 Query: 434 LVGYCCED 457 G CCED Sbjct: 962 YKG-CCED 968
>EPHB3_BRARE (O13147) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK3) (EPH-like kinase 3) (Fragment) Length = 500 Score = 38.1 bits (87), Expect = 0.012 Identities = 26/94 (27%), Positives = 41/94 (43%), Gaps = 9/94 (9%) Frame = +2 Query: 188 FTFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK 340 FT+E+ F ++ V+G G FG V +G R A + VA+K Sbjct: 166 FTYEDPNEAVHEFAREIDISCVKIEEVIGAGEFGEVCRG------RLKQAGRKETTVAIK 219 Query: 341 VHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + R++L+E +GQ HPN++ L G Sbjct: 220 TLKAGYTEHQRRDFLSEASIMGQFDHPNVIHLEG 253
>MIPR_LYMST (Q25410) Putative molluscan insulin-related peptide(s) receptor| precursor (EC 2.7.10.1) [Contains: Putative molluscan insulin-related peptide(s) receptor alpha chain; Putative molluscan insulin-related peptide(s) receptor beta chain] Length = 1607 Score = 38.1 bits (87), Expect = 0.012 Identities = 27/67 (40%), Positives = 37/67 (55%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G FG VY+G VA +R+ E P VAVK + SF RE+L E + + Sbjct: 1043 LGQGSFGMVYEG-VAKGIRDDPNEEIP--VAVKTVNDRASFSDRREFLKEATTMKEFHCH 1099 Query: 422 NLVKLVG 442 ++VKL+G Sbjct: 1100 HVVKLLG 1106
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 38.1 bits (87), Expect = 0.012 Identities = 21/71 (29%), Positives = 38/71 (53%) Frame = +2 Query: 230 QDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQ 409 + V+G G FG VYKG + + + ++ + VA+K + + ++L+E +GQ Sbjct: 616 RQKVIGAGEFGEVYKGTL-----KASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQ 670 Query: 410 LSHPNLVKLVG 442 SH N++ L G Sbjct: 671 FSHHNIIPLEG 681
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 38.1 bits (87), Expect = 0.012 Identities = 28/107 (26%), Positives = 49/107 (45%), Gaps = 3/107 (2%) Frame = +2 Query: 167 RKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVH 346 +K P+ +F+ + TK+F +D ++G G VY+ + N AVK+ Sbjct: 162 QKTPI---SFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRNQ-----------AYAVKLF 207 Query: 347 DGDNSFQGHREW---LAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 + Q + W L+E+ L HP++++L Y E + LVY Sbjct: 208 KQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLCLVY 254
>LTK_HUMAN (P29376) Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1)| (Protein tyrosine kinase 1) Length = 864 Score = 38.1 bits (87), Expect = 0.012 Identities = 26/79 (32%), Positives = 40/79 (50%), Gaps = 1/79 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEE-PLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 LG G FG VY+G V GL + PL+VA+K S Q ++L E + + + H Sbjct: 516 LGHGAFGEVYEGLVI-----GLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRH 570 Query: 419 PNLVKLVGYCCEDDHRVLV 475 N+V+ VG R+++ Sbjct: 571 QNIVRCVGLSLRATPRLIL 589
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 37.7 bits (86), Expect = 0.016 Identities = 21/71 (29%), Positives = 37/71 (52%) Frame = +2 Query: 230 QDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQ 409 + V+G G FG VYKG + + ++ + VA+K + + ++L E +GQ Sbjct: 615 RQKVIGAGEFGEVYKGMLKTS-----SGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQ 669 Query: 410 LSHPNLVKLVG 442 SH N+++L G Sbjct: 670 FSHHNIIRLEG 680
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 37.7 bits (86), Expect = 0.016 Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 2/82 (2%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVAND-LREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLS 415 V+G G FG+V K + D LR AI+ A K HR++ E+ L +L Sbjct: 827 VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASK--------DDHRDFAGELEVLCKLG 878 Query: 416 H-PNLVKLVGYCCEDDHRVLVY 478 H PN++ L+G C +HR +Y Sbjct: 879 HHPNIINLLGAC---EHRGYLY 897
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 37.7 bits (86), Expect = 0.016 Identities = 25/81 (30%), Positives = 36/81 (44%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + ++GVGGFG+VY+ L G EE A ++ + + E G L Sbjct: 101 EEIIGVGGFGKVYRA-----LWRG---EEVAVKAARLDPEKDPAVTAEQVCQEARLFGAL 152 Query: 413 SHPNLVKLVGYCCEDDHRVLV 475 HPN++ L G C H LV Sbjct: 153 QHPNIIALRGACLNPPHLCLV 173
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 37.7 bits (86), Expect = 0.016 Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 2/82 (2%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVAND-LREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLS 415 V+G G FG+V K + D LR AI+ A K HR++ E+ L +L Sbjct: 829 VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASK--------DDHRDFAGELEVLCKLG 880 Query: 416 H-PNLVKLVGYCCEDDHRVLVY 478 H PN++ L+G C +HR +Y Sbjct: 881 HHPNIINLLGAC---EHRGYLY 899
>RTK2_GEOCY (P42159) Class II receptor tyrosine kinase (EC 2.7.10.1) (GCTK)| Length = 605 Score = 37.7 bits (86), Expect = 0.016 Identities = 39/151 (25%), Positives = 60/151 (39%), Gaps = 11/151 (7%) Frame = +2 Query: 56 SVAESPKLQSP-SERIEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQ 232 SVA +P + + S I DD L P P ++ + L N R+ Sbjct: 299 SVAINPSMFTKRSSTIGNDDDLHPYGPIYARPIKQKMR----------QPLNVSVDNIRE 348 Query: 233 DSVLGVGGFGRVY----------KGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREW 382 +GVG FG V + CV R+ + VAVK D S + + + Sbjct: 349 VKQIGVGQFGAVVLAEMTGLSGSERCVPTK-RDPSMLNGVALVAVKKLKPDVSEEVRQSF 407 Query: 383 LAEVIFLGQLSHPNLVKLVGYCCEDDHRVLV 475 E+ F+ QL H ++V+L+ C H +V Sbjct: 408 DKEIKFVSQLQHDSIVQLLAVCTHSKHPFIV 438
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 37.7 bits (86), Expect = 0.016 Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 2/82 (2%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVAND-LREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLS 415 V+G G FG+V K + D LR AI+ A K HR++ E+ L +L Sbjct: 830 VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASK--------DDHRDFAGELEVLCKLG 881 Query: 416 H-PNLVKLVGYCCEDDHRVLVY 478 H PN++ L+G C +HR +Y Sbjct: 882 HHPNIINLLGAC---EHRGYLY 900
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 37.4 bits (85), Expect = 0.021 Identities = 20/67 (29%), Positives = 35/67 (52%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 +G+G FG V G R + + + VA+K + + R++L+E +GQ HP Sbjct: 1 IGIGEFGEVCSG------RLKMPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP 54 Query: 422 NLVKLVG 442 N+++L G Sbjct: 55 NIIRLEG 61
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 37.4 bits (85), Expect = 0.021 Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 9/93 (9%) Frame = +2 Query: 191 TFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKV 343 T+E+ R F ++ V+G G FG V G R L + + VA+K Sbjct: 613 TYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSG------RLKLPGQRDVAVAIKT 666 Query: 344 HDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L E +GQ HPN+V L G Sbjct: 667 LKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEG 699
>ERBB2_HUMAN (P04626) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19) Length = 1255 Score = 37.4 bits (85), Expect = 0.021 Identities = 26/74 (35%), Positives = 39/74 (52%) Frame = +2 Query: 227 RQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLG 406 R+ VLG G FG VYKG D G ++ P VA+KV + S + ++E L E + Sbjct: 721 RKVKVLGSGAFGTVYKGIWIPD---GENVKIP--VAIKVLRENTSPKANKEILDEAYVMA 775 Query: 407 QLSHPNLVKLVGYC 448 + P + +L+G C Sbjct: 776 GVGSPYVSRLLGIC 789
>ERBB2_RAT (P06494) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Epidermal growth factor receptor-related protein) Length = 1257 Score = 37.4 bits (85), Expect = 0.021 Identities = 26/74 (35%), Positives = 39/74 (52%) Frame = +2 Query: 227 RQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLG 406 R+ VLG G FG VYKG D G ++ P VA+KV + S + ++E L E + Sbjct: 723 RKVKVLGSGAFGTVYKGIWIPD---GENVKIP--VAIKVLRENTSPKANKEILDEAYVMA 777 Query: 407 QLSHPNLVKLVGYC 448 + P + +L+G C Sbjct: 778 GVGSPYVSRLLGIC 791
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 37.4 bits (85), Expect = 0.021 Identities = 26/78 (33%), Positives = 37/78 (47%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 +G G FG VYK + + L VAVK + R++L E L Q HP Sbjct: 1069 IGRGNFGDVYKAKLKST---------KLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHP 1119 Query: 422 NLVKLVGYCCEDDHRVLV 475 N+VKL+G C + ++V Sbjct: 1120 NIVKLIGICVQKQPIMIV 1137
>ERBB2_CANFA (O18735) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) Length = 1259 Score = 37.4 bits (85), Expect = 0.021 Identities = 26/74 (35%), Positives = 39/74 (52%) Frame = +2 Query: 227 RQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLG 406 R+ VLG G FG VYKG D G ++ P VA+KV + S + ++E L E + Sbjct: 720 RKVKVLGSGAFGTVYKGIWIPD---GENVKIP--VAIKVLRENTSPKANKEILDEAYVMA 774 Query: 407 QLSHPNLVKLVGYC 448 + P + +L+G C Sbjct: 775 GVGSPYVSRLLGIC 788
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 37.4 bits (85), Expect = 0.021 Identities = 23/70 (32%), Positives = 34/70 (48%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + V+G G FG V G R L + L VA+K + + R++L E +GQ Sbjct: 678 ERVIGAGEFGEVCSG------RLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQF 731 Query: 413 SHPNLVKLVG 442 HPN++ L G Sbjct: 732 DHPNIIHLEG 741
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 37.0 bits (84), Expect = 0.027 Identities = 40/131 (30%), Positives = 58/131 (44%), Gaps = 2/131 (1%) Frame = +2 Query: 83 SPSERIEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFG 262 SP +R + S L + +A + AR + + LK +F VLG G FG Sbjct: 64 SPGKRPTLEISELKNVSPINQAHKTGKARAGGVPLSKLQNLK--LADFEIGKVLGKGKFG 121 Query: 263 RVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGH--REWLAEVIFLGQLSHPNLVKL 436 RVY CV + IE A+K + + Q + +++ EV L HPNL +L Sbjct: 122 RVY--CVRH-------IESGFVCALKAMEKKDIIQYNIEKQFRREVEIQSSLRHPNLTQL 172 Query: 437 VGYCCEDDHRV 469 GY D+ RV Sbjct: 173 YGY-FHDEKRV 182
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 37.0 bits (84), Expect = 0.027 Identities = 25/75 (33%), Positives = 37/75 (49%), Gaps = 2/75 (2%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDN--SFQGHREWLAEVIFLGQL 412 ++G G FG+VYKG N + VA+K + + S + EV L QL Sbjct: 467 IIGSGSFGKVYKGRCRNKI-----------VAIKRYRANTYCSKSDVDMFCREVSILCQL 515 Query: 413 SHPNLVKLVGYCCED 457 +HP +V+ VG C +D Sbjct: 516 NHPCVVQFVGACLDD 530
>ERBB2_MOUSE (P70424) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) Length = 1256 Score = 37.0 bits (84), Expect = 0.027 Identities = 26/74 (35%), Positives = 39/74 (52%) Frame = +2 Query: 227 RQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLG 406 R+ VLG G FG VYKG D G ++ P VA+KV + S + ++E L E + Sbjct: 722 RKLKVLGSGAFGTVYKGIWIPD---GENVKIP--VAIKVLRENTSPKANKEILDEAYVMA 776 Query: 407 QLSHPNLVKLVGYC 448 + P + +L+G C Sbjct: 777 GVGSPYVSRLLGIC 790
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 37.0 bits (84), Expect = 0.027 Identities = 25/75 (33%), Positives = 37/75 (49%), Gaps = 2/75 (2%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDN--SFQGHREWLAEVIFLGQL 412 ++G G FG+VYKG N + VA+K + + S + EV L QL Sbjct: 466 IIGSGSFGKVYKGRCRNKI-----------VAIKRYRANTYCSKSDVDMFCREVSILCQL 514 Query: 413 SHPNLVKLVGYCCED 457 +HP +V+ VG C +D Sbjct: 515 NHPCVVQFVGACLDD 529
>MET_MOUSE (P16056) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1379 Score = 37.0 bits (84), Expect = 0.027 Identities = 24/81 (29%), Positives = 41/81 (50%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + V+G G FG VY G + ++ +G + + AVK + + ++L E I + Sbjct: 1079 NEVIGRGHFGCVYHGTLLDN--DG----KKIHCAVKSLNRITDIEEVSQFLTEGIIMKDF 1132 Query: 413 SHPNLVKLVGYCCEDDHRVLV 475 SHPN++ L+G C + LV Sbjct: 1133 SHPNVLSLLGICLRSEGSPLV 1153
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 37.0 bits (84), Expect = 0.027 Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 9/93 (9%) Frame = +2 Query: 191 TFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKV 343 T+E+ R F ++ V+G G FG V G R L + + VA+K Sbjct: 613 TYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSG------RLKLPGKRDVAVAIKT 666 Query: 344 HDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L E +GQ HPN+V L G Sbjct: 667 LKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEG 699
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 37.0 bits (84), Expect = 0.027 Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 9/93 (9%) Frame = +2 Query: 191 TFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKV 343 T+E+ R F ++ V+G G FG V G R L + + VA+K Sbjct: 613 TYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSG------RLKLPGKRDVAVAIKT 666 Query: 344 HDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L E +GQ HPN+V L G Sbjct: 667 LKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEG 699
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 37.0 bits (84), Expect = 0.027 Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 9/93 (9%) Frame = +2 Query: 191 TFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKV 343 T+E+ R F ++ V+G G FG V G R L + + VA+K Sbjct: 608 TYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSG------RLKLPGKRDVAVAIKT 661 Query: 344 HDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L E +GQ HPN+V L G Sbjct: 662 LKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEG 694
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 37.0 bits (84), Expect = 0.027 Identities = 15/38 (39%), Positives = 24/38 (63%) Frame = +2 Query: 329 VAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 VA+K +S + E+L E +GQ SHPN+++L+G Sbjct: 745 VAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIG 782
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 37.0 bits (84), Expect = 0.027 Identities = 26/79 (32%), Positives = 42/79 (53%) Frame = +2 Query: 224 FRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFL 403 +R+ ++G G FG VY G + D E LA+++ L + + + +E EV L Sbjct: 68 WRKGQLIGRGAFGTVYMG-MNLDSGELLAVKQVL-ITSNCASKEKTQAHIQELEEEVKLL 125 Query: 404 GQLSHPNLVKLVGYCCEDD 460 LSHPN+V+ +G ED+ Sbjct: 126 KNLSHPNIVRYLGTVREDE 144
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 37.0 bits (84), Expect = 0.027 Identities = 24/71 (33%), Positives = 39/71 (54%), Gaps = 1/71 (1%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGH-REWLAEVIFLGQ 409 D+V+G G FG VY+G + L ++ VA+K D S G+ +L E +GQ Sbjct: 628 DTVIGEGEFGEVYRGALR------LPSQDCKTVAIKTLK-DTSPDGYWWNFLREATIMGQ 680 Query: 410 LSHPNLVKLVG 442 +HP++++L G Sbjct: 681 FNHPHILRLEG 691
>YL670_MIMIV (Q5UNT4) Putative serine/threonine-protein kinase L670 (EC| 2.7.11.1) Length = 539 Score = 37.0 bits (84), Expect = 0.027 Identities = 26/87 (29%), Positives = 38/87 (43%) Frame = +2 Query: 185 AFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSF 364 + T E + N LG+G FG V K N +A+K H D+S Sbjct: 245 SLTIEYTENQLNNMNVIEKLGIGSFGLVNKVKFDNT-----------EIALKTHHPDDSK 293 Query: 365 QGHREWLAEVIFLGQLSHPNLVKLVGY 445 + E L E+ + L HPN++K+ GY Sbjct: 294 EIIVESLREINNMIMLDHPNIIKMHGY 320
>UFO_HUMAN (P30530) Tyrosine-protein kinase receptor UFO precursor (EC| 2.7.10.1) (AXL oncogene) Length = 887 Score = 36.6 bits (83), Expect = 0.035 Identities = 34/131 (25%), Positives = 58/131 (44%), Gaps = 8/131 (6%) Frame = +2 Query: 98 IEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQD-------SVLGVGG 256 +E+ + ++ R+ + R A N L EELK ++ D LG G Sbjct: 482 VERGELVVRYRVRKSYSRRTTEATLNSL--GISEELKEKLRDVMVDRHKVALGKTLGEGE 539 Query: 257 FGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHRE-WLAEVIFLGQLSHPNLVK 433 FG V +G + D + L+VAVK + E +L+E + + + HPN+++ Sbjct: 540 FGAVMEGQLNQD-------DSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMR 592 Query: 434 LVGYCCEDDHR 466 L+G C + R Sbjct: 593 LIGVCFQGSER 603
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 36.6 bits (83), Expect = 0.035 Identities = 23/70 (32%), Positives = 34/70 (48%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + V+G G FG V G R L + L VA K + + R++L+E +GQ Sbjct: 680 ERVIGAGEFGEVCSG------RLKLPGKRELPVATKTLKVGYTEKQRRDFLSEASIMGQF 733 Query: 413 SHPNLVKLVG 442 HPN++ L G Sbjct: 734 DHPNIIHLEG 743
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 36.6 bits (83), Expect = 0.035 Identities = 25/72 (34%), Positives = 35/72 (48%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G +G VY EG+ + L VAVK D E+L E + ++ HP Sbjct: 134 LGGGQYGEVY---------EGVWKKYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 182 Query: 422 NLVKLVGYCCED 457 NLV+L+G C + Sbjct: 183 NLVQLLGVCTRE 194
>FAK1_RAT (O35346) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1055 Score = 36.6 bits (83), Expect = 0.035 Identities = 24/73 (32%), Positives = 37/73 (50%), Gaps = 1/73 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEP-LRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +G G FG V++G L+ E P L VA+K S ++L E + + Q H Sbjct: 428 IGEGQFGDVHQGVY-------LSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDH 480 Query: 419 PNLVKLVGYCCED 457 P++VKL+G E+ Sbjct: 481 PHIVKLIGVITEN 493
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 36.6 bits (83), Expect = 0.035 Identities = 25/72 (34%), Positives = 35/72 (48%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G +G VY EG+ + L VAVK D E+L E + ++ HP Sbjct: 248 LGGGQYGEVY---------EGVWKKYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 296 Query: 422 NLVKLVGYCCED 457 NLV+L+G C + Sbjct: 297 NLVQLLGVCTRE 308
>E2AK3_CAEEL (Q19192) Eukaryotic translation initiation factor 2-alpha kinase| precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (PERK) (PEK) (CePEK) Length = 1077 Score = 36.6 bits (83), Expect = 0.035 Identities = 29/103 (28%), Positives = 45/103 (43%) Frame = +2 Query: 125 SNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREG 304 SN + LRN + ++ L FT R F V+G GGFG V++ D+ E Sbjct: 575 SNDEKKRLLRNRTISRSSLEGFT----SRFANEFEVKKVIGHGGFGVVFRAQSITDMNE- 629 Query: 305 LAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVK 433 A++ R+AV +D + L E L HP +++ Sbjct: 630 YAVK---RIAVADND-----KARNRVLREARALAMFDHPGIIR 664
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 36.6 bits (83), Expect = 0.035 Identities = 25/72 (34%), Positives = 35/72 (48%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G +G VY EG+ + L VAVK D E+L E + ++ HP Sbjct: 197 LGGGQYGEVY---------EGVWKKYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 245 Query: 422 NLVKLVGYCCED 457 NLV+L+G C + Sbjct: 246 NLVQLLGVCTRE 257
>MET_RAT (P97523) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 36.6 bits (83), Expect = 0.035 Identities = 24/81 (29%), Positives = 40/81 (49%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + V+G G FG VY G + + +G + + AVK + + ++L E I + Sbjct: 1082 NEVIGRGHFGCVYHGTLLDS--DG----KKIHCAVKSLNRITDIEEVSQFLTEGIIMKDF 1135 Query: 413 SHPNLVKLVGYCCEDDHRVLV 475 SHPN++ L+G C + LV Sbjct: 1136 SHPNVLSLLGICLRSEGSPLV 1156
>FAK1_MOUSE (P34152) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1090 Score = 36.6 bits (83), Expect = 0.035 Identities = 24/73 (32%), Positives = 37/73 (50%), Gaps = 1/73 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEP-LRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +G G FG V++G L+ E P L VA+K S ++L E + + Q H Sbjct: 466 IGEGQFGDVHQGVY-------LSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDH 518 Query: 419 PNLVKLVGYCCED 457 P++VKL+G E+ Sbjct: 519 PHIVKLIGVITEN 531
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 36.6 bits (83), Expect = 0.035 Identities = 25/72 (34%), Positives = 35/72 (48%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G +G VY EG+ + L VAVK D E+L E + ++ HP Sbjct: 248 LGGGQYGEVY---------EGVWKKYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 296 Query: 422 NLVKLVGYCCED 457 NLV+L+G C + Sbjct: 297 NLVQLLGVCTRE 308
>UFO_MOUSE (Q00993) Tyrosine-protein kinase receptor UFO precursor (EC| 2.7.10.1) (Adhesion-related kinase) Length = 888 Score = 36.2 bits (82), Expect = 0.046 Identities = 34/131 (25%), Positives = 58/131 (44%), Gaps = 8/131 (6%) Frame = +2 Query: 98 IEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQD-------SVLGVGG 256 +E+ + ++ R+ + R A N L EELK ++ D LG G Sbjct: 483 VERGELVVRYRVRKSYSRRTTEATLNSL--GISEELKEKLRDVMVDRHKVALGKTLGEGE 540 Query: 257 FGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHRE-WLAEVIFLGQLSHPNLVK 433 FG V +G + D + L+VAVK + E +L+E + + + HPN+++ Sbjct: 541 FGAVMEGQLNQD-------DSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMR 593 Query: 434 LVGYCCEDDHR 466 L+G C + R Sbjct: 594 LIGVCFQGSDR 604
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 36.2 bits (82), Expect = 0.046 Identities = 25/79 (31%), Positives = 38/79 (48%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G FG+V+ N E ++ + VAVK D S +++ E L L H Sbjct: 543 LGEGAFGKVFLAECYNLCPE----QDKILVAVKTLK-DASDNARKDFHREAELLTNLQHE 597 Query: 422 NLVKLVGYCCEDDHRVLVY 478 ++VK G C E D ++V+ Sbjct: 598 HIVKFYGVCVEGDPLIMVF 616
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 36.2 bits (82), Expect = 0.046 Identities = 25/79 (31%), Positives = 38/79 (48%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G FG+V+ N E ++ + VAVK D S +++ E L L H Sbjct: 543 LGEGAFGKVFLAECYNLCPE----QDKILVAVKTLK-DASDNARKDFHREAELLTNLQHE 597 Query: 422 NLVKLVGYCCEDDHRVLVY 478 ++VK G C E D ++V+ Sbjct: 598 HIVKFYGVCVEGDPLIMVF 616
>MUSK_HUMAN (O15146) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 869 Score = 36.2 bits (82), Expect = 0.046 Identities = 23/70 (32%), Positives = 35/70 (50%), Gaps = 1/70 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLR-VAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +G G FGRV++ GL EP VAVK+ + S ++ E + + + Sbjct: 581 IGEGAFGRVFQARAP-----GLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 635 Query: 419 PNLVKLVGYC 448 PN+VKL+G C Sbjct: 636 PNIVKLLGVC 645
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 36.2 bits (82), Expect = 0.046 Identities = 25/79 (31%), Positives = 38/79 (48%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G FG+V+ N E ++ + VAVK D S +++ E L L H Sbjct: 540 LGEGAFGKVFLAECYNLCPE----QDKILVAVKTLK-DASDNARKDFHREAELLTNLQHE 594 Query: 422 NLVKLVGYCCEDDHRVLVY 478 ++VK G C E D ++V+ Sbjct: 595 HIVKFYGVCVEGDPLIMVF 613
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 36.2 bits (82), Expect = 0.046 Identities = 22/70 (31%), Positives = 35/70 (50%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 D+V+G G FG VY+G + L ++ VA+K + +L E +GQ Sbjct: 627 DTVIGEGEFGEVYRGTLR------LPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQF 680 Query: 413 SHPNLVKLVG 442 SHP+++ L G Sbjct: 681 SHPHILHLEG 690
>MUSK_RAT (Q62838) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 36.2 bits (82), Expect = 0.046 Identities = 23/70 (32%), Positives = 35/70 (50%), Gaps = 1/70 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLR-VAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +G G FGRV++ GL EP VAVK+ + S ++ E + + + Sbjct: 580 IGEGAFGRVFQARAP-----GLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 634 Query: 419 PNLVKLVGYC 448 PN+VKL+G C Sbjct: 635 PNIVKLLGVC 644
>MUSK_MOUSE (Q61006) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 36.2 bits (82), Expect = 0.046 Identities = 23/70 (32%), Positives = 35/70 (50%), Gaps = 1/70 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLR-VAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +G G FGRV++ GL EP VAVK+ + S ++ E + + + Sbjct: 580 IGEGAFGRVFQARAP-----GLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 634 Query: 419 PNLVKLVGYC 448 PN+VKL+G C Sbjct: 635 PNIVKLLGVC 644
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 36.2 bits (82), Expect = 0.046 Identities = 25/79 (31%), Positives = 38/79 (48%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G FG+V+ N E ++ + VAVK D S +++ E L L H Sbjct: 544 LGEGAFGKVFLAECYNLCPE----QDKILVAVKTLK-DASDNARKDFHREAELLTNLQHE 598 Query: 422 NLVKLVGYCCEDDHRVLVY 478 ++VK G C E D ++V+ Sbjct: 599 HIVKFYGVCVEGDPLIMVF 617
>FAK1_HUMAN (Q05397) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| (Protein-tyrosine kinase 2) Length = 1052 Score = 36.2 bits (82), Expect = 0.046 Identities = 22/72 (30%), Positives = 35/72 (48%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 +G G FG V++G + LA VA+K S ++L E + + Q HP Sbjct: 428 IGEGQFGDVHQGIYMSPENPALA------VAIKTCKNCTSDSVREKFLQEALTMRQFDHP 481 Query: 422 NLVKLVGYCCED 457 ++VKL+G E+ Sbjct: 482 HIVKLIGVITEN 493
>MUSK_CHICK (Q8AXY6) Muscle, skeletal receptor tyrosine protein kinase| precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 947 Score = 36.2 bits (82), Expect = 0.046 Identities = 23/70 (32%), Positives = 35/70 (50%), Gaps = 1/70 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLR-VAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 +G G FGRV++ GL EP VAVK+ + S ++ E + + + Sbjct: 661 IGEGAFGRVFQARAP-----GLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 715 Query: 419 PNLVKLVGYC 448 PN+VKL+G C Sbjct: 716 PNIVKLLGVC 725
>MET_PIG (Q2QLE0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 36.2 bits (82), Expect = 0.046 Identities = 23/81 (28%), Positives = 39/81 (48%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + V+G G FG VY G + ++ ++ + AVK + ++L E I + Sbjct: 1081 NEVIGRGHFGCVYHGTLLDN------DDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF 1134 Query: 413 SHPNLVKLVGYCCEDDHRVLV 475 SHPN++ L+G C + LV Sbjct: 1135 SHPNVLSLLGICLRSEGSPLV 1155
>MET_HORSE (Q2QLA9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 36.2 bits (82), Expect = 0.046 Identities = 23/81 (28%), Positives = 39/81 (48%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + V+G G FG VY G + ++ ++ + AVK + ++L E I + Sbjct: 1081 NEVIGRGHFGCVYHGTLLDN------DDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF 1134 Query: 413 SHPNLVKLVGYCCEDDHRVLV 475 SHPN++ L+G C + LV Sbjct: 1135 SHPNVLSLLGICLRSEGSPLV 1155
>MET_CANFA (Q75ZY9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 36.2 bits (82), Expect = 0.046 Identities = 23/81 (28%), Positives = 39/81 (48%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + V+G G FG VY G + ++ ++ + AVK + ++L E I + Sbjct: 1082 NEVIGRGHFGCVYHGTLLDN------DDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF 1135 Query: 413 SHPNLVKLVGYCCEDDHRVLV 475 SHPN++ L+G C + LV Sbjct: 1136 SHPNVLSLLGICLRSEGSPLV 1156
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 35.8 bits (81), Expect = 0.060 Identities = 28/86 (32%), Positives = 44/86 (51%), Gaps = 3/86 (3%) Frame = +2 Query: 230 QDSVLGVGGFGRVYKGCVANDLREGLAIE-EPLRVAVKVHDGDNSFQGHRE--WLAEVIF 400 + +V+G G G+VYK +LR G + + L +VK D + S + AEV Sbjct: 685 EKNVIGFGSSGKVYKV----ELRGGEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAEVET 740 Query: 401 LGQLSHPNLVKLVGYCCEDDHRVLVY 478 LG + H ++V+L C D ++LVY Sbjct: 741 LGTIRHKSIVRLWCCCSSGDCKLLVY 766
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 35.8 bits (81), Expect = 0.060 Identities = 22/70 (31%), Positives = 33/70 (47%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + V+G G FG V G R L + VA+K + + R++L E +GQ Sbjct: 654 ERVIGAGEFGEVCSG------RLKLQGKREFPVAIKTLKVGYTEKQRRDFLGEASIMGQF 707 Query: 413 SHPNLVKLVG 442 HPN++ L G Sbjct: 708 DHPNIIHLEG 717
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 35.8 bits (81), Expect = 0.060 Identities = 24/75 (32%), Positives = 36/75 (48%), Gaps = 2/75 (2%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDN--SFQGHREWLAEVIFLGQL 412 ++G G FG+VYKG N + VA+K + + S + EV L QL Sbjct: 467 IIGSGSFGKVYKGRCRNKI-----------VAIKRYRANTYCSKSDVDMFCREVSILCQL 515 Query: 413 SHPNLVKLVGYCCED 457 +HP +++ VG C D Sbjct: 516 NHPCVIQFVGACLND 530
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 35.8 bits (81), Expect = 0.060 Identities = 24/75 (32%), Positives = 36/75 (48%), Gaps = 2/75 (2%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDN--SFQGHREWLAEVIFLGQL 412 ++G G FG+VYKG N + VA+K + + S + EV L QL Sbjct: 569 IIGSGSFGKVYKGRCRNKI-----------VAIKRYRANTYCSKSDVDMFCREVSILCQL 617 Query: 413 SHPNLVKLVGYCCED 457 +HP +++ VG C D Sbjct: 618 NHPCVIQFVGACLND 632
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 35.8 bits (81), Expect = 0.060 Identities = 26/83 (31%), Positives = 39/83 (46%), Gaps = 1/83 (1%) Frame = +2 Query: 197 EELKRITKNF-RQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGH 373 E K I +F + + V+G G FG V C G + VA+K + + Sbjct: 627 EFAKEIDVSFIKIEEVIGSGEFGEV---CFGRLKHPG---KREYTVAIKTLKSGYTDEQR 680 Query: 374 REWLAEVIFLGQLSHPNLVKLVG 442 RE+L+E +GQ HPN++ L G Sbjct: 681 REFLSEASIMGQFEHPNVIHLEG 703
>MET_CALMO (Q2QLC0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 35.8 bits (81), Expect = 0.060 Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 1/82 (1%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHD-GDNSFQGHREWLAEVIFLGQ 409 + V+G G FG VY G + ++ +G I ++ ++ D G+ S ++L E I + Sbjct: 1081 NEVIGRGHFGCVYHGTLLDN--DGKKIHCAVKSLNRITDIGEVS-----QFLTEGIIMKD 1133 Query: 410 LSHPNLVKLVGYCCEDDHRVLV 475 SHPN++ L+G C + LV Sbjct: 1134 FSHPNVLSLLGICLRSEGSPLV 1155
>MET_CALJA (Q2QLG5) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 35.8 bits (81), Expect = 0.060 Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 1/82 (1%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHD-GDNSFQGHREWLAEVIFLGQ 409 + V+G G FG VY G + ++ +G I ++ ++ D G+ S ++L E I + Sbjct: 1081 NEVIGRGHFGCVYHGTLLDN--DGKKIHCAVKSLNRITDIGEVS-----QFLTEGIIMKD 1133 Query: 410 LSHPNLVKLVGYCCEDDHRVLV 475 SHPN++ L+G C + LV Sbjct: 1134 FSHPNVLSLLGICLRSEGSPLV 1155
>MET_PONPY (Q2IBD8) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 35.8 bits (81), Expect = 0.060 Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 1/82 (1%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHD-GDNSFQGHREWLAEVIFLGQ 409 + V+G G FG VY G + ++ +G I ++ ++ D G+ S ++L E I + Sbjct: 1081 NEVIGRGHFGCVYHGTLLDN--DGKKIHCAVKSLNRITDIGEVS-----QFLTEGIIMKD 1133 Query: 410 LSHPNLVKLVGYCCEDDHRVLV 475 SHPN++ L+G C + LV Sbjct: 1134 FSHPNVLSLLGICLRSEGSPLV 1155
>MET_PANTR (Q2QLF1) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 35.8 bits (81), Expect = 0.060 Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 1/82 (1%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHD-GDNSFQGHREWLAEVIFLGQ 409 + V+G G FG VY G + ++ +G I ++ ++ D G+ S ++L E I + Sbjct: 1081 NEVIGRGHFGCVYHGTLLDN--DGKKIHCAVKSLNRITDIGEVS-----QFLTEGIIMKD 1133 Query: 410 LSHPNLVKLVGYCCEDDHRVLV 475 SHPN++ L+G C + LV Sbjct: 1134 FSHPNVLSLLGICLRSEGSPLV 1155
>MET_HUMAN (P08581) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 35.8 bits (81), Expect = 0.060 Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 1/82 (1%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHD-GDNSFQGHREWLAEVIFLGQ 409 + V+G G FG VY G + ++ +G I ++ ++ D G+ S ++L E I + Sbjct: 1081 NEVIGRGHFGCVYHGTLLDN--DGKKIHCAVKSLNRITDIGEVS-----QFLTEGIIMKD 1133 Query: 410 LSHPNLVKLVGYCCEDDHRVLV 475 SHPN++ L+G C + LV Sbjct: 1134 FSHPNVLSLLGICLRSEGSPLV 1155
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 35.8 bits (81), Expect = 0.060 Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 1/82 (1%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHD-GDNSFQGHREWLAEVIFLGQ 409 + V+G G FG VY G + ++ +G I ++ ++ D G+ S ++L E I + Sbjct: 1082 NEVIGRGHFGCVYHGTLLDN--DGKKIHCAVKSLNRITDIGEVS-----QFLTEGIIMKD 1134 Query: 410 LSHPNLVKLVGYCCEDDHRVLV 475 SHPN++ L+G C + LV Sbjct: 1135 FSHPNVLSLLGICLRSEGSPLV 1156
>MET_MICMU (Q2QL89) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 35.8 bits (81), Expect = 0.060 Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 1/82 (1%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHD-GDNSFQGHREWLAEVIFLGQ 409 + V+G G FG VY G + ++ +G I ++ ++ D G+ S ++L E I + Sbjct: 1082 NEVIGRGHFGCVYHGTLLDN--DGKKIHCAVKSLNRITDIGEVS-----QFLTEGIIMKD 1134 Query: 410 LSHPNLVKLVGYCCEDDHRVLV 475 SHPN++ L+G C + LV Sbjct: 1135 FSHPNVLSLLGICLRSEGSPLV 1156
>INSR_XENLA (Q9PVZ4) Insulin receptor precursor (EC 2.7.10.1) (IR) (Xe-InsR)| (XTK-1b) [Contains: Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1362 Score = 35.4 bits (80), Expect = 0.078 Identities = 24/67 (35%), Positives = 38/67 (56%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G FG VY+G +A D+ +G E +RVAVK + S + E+L E + + Sbjct: 1018 LGQGSFGMVYEG-IAKDIIKG---EPEVRVAVKTVNESASLRERIEFLNEASVMKAFNCH 1073 Query: 422 NLVKLVG 442 ++V+L+G Sbjct: 1074 HVVRLLG 1080
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 35.4 bits (80), Expect = 0.078 Identities = 21/73 (28%), Positives = 41/73 (56%), Gaps = 1/73 (1%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + ++G G FG+V + + D GL + +++ +K + +N HR++ E+ L +L Sbjct: 840 EDLIGEGNFGQVIRAMIKKD---GLKMNAAIKM-LKEYASEND---HRDFAGELEVLCKL 892 Query: 413 SH-PNLVKLVGYC 448 H PN++ L+G C Sbjct: 893 GHHPNIINLLGAC 905
>FAK1_XENLA (Q91738) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1068 Score = 35.4 bits (80), Expect = 0.078 Identities = 21/72 (29%), Positives = 35/72 (48%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 +G G FG V++G + +A VA+K S ++L E + + Q HP Sbjct: 441 IGEGQFGDVHQGVYMSPENPAMA------VAIKTCKNCTSDSVREKFLQEALTMRQFDHP 494 Query: 422 NLVKLVGYCCED 457 ++VKL+G E+ Sbjct: 495 HIVKLIGVITEN 506
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 35.4 bits (80), Expect = 0.078 Identities = 21/73 (28%), Positives = 41/73 (56%), Gaps = 1/73 (1%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + ++G G FG+V + + D GL + +++ +K + +N HR++ E+ L +L Sbjct: 838 EDLIGEGNFGQVIRAMIKKD---GLKMNAAIKM-LKEYASEND---HRDFAGELEVLCKL 890 Query: 413 SH-PNLVKLVGYC 448 H PN++ L+G C Sbjct: 891 GHHPNIINLLGAC 903
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 35.4 bits (80), Expect = 0.078 Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 9/93 (9%) Frame = +2 Query: 191 TFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKV 343 T+EE R ++F ++ ++G G G V G R + + + VA+K Sbjct: 615 TYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYG------RLRVPGQRDVPVAIKA 668 Query: 344 HDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + R++L+E +GQ HPN+++L G Sbjct: 669 LKAGYTERQRRDFLSEASIMGQFDHPNIIRLEG 701
>TIE1_HUMAN (P35590) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1138 Score = 35.4 bits (80), Expect = 0.078 Identities = 21/73 (28%), Positives = 41/73 (56%), Gaps = 1/73 (1%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 + ++G G FG+V + + D GL + +++ +K + +N HR++ E+ L +L Sbjct: 842 EDLIGEGNFGQVIRAMIKKD---GLKMNAAIKM-LKEYASEND---HRDFAGELEVLCKL 894 Query: 413 SH-PNLVKLVGYC 448 H PN++ L+G C Sbjct: 895 GHHPNIINLLGAC 907
>FAK1_CHICK (Q00944) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1053 Score = 35.4 bits (80), Expect = 0.078 Identities = 21/72 (29%), Positives = 35/72 (48%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 +G G FG V++G + +A VA+K S ++L E + + Q HP Sbjct: 428 IGEGQFGDVHQGIYMSPENPAMA------VAIKTCKNCTSDSVREKFLQEALTMRQFDHP 481 Query: 422 NLVKLVGYCCED 457 ++VKL+G E+ Sbjct: 482 HIVKLIGVITEN 493
>WIN1_SCHPO (O74304) MAP kinase kinase kinase win1 (EC 2.7.11.25)| Length = 1436 Score = 35.4 bits (80), Expect = 0.078 Identities = 26/96 (27%), Positives = 45/96 (46%) Frame = +2 Query: 155 NDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVA 334 +D+ ++N L+ IT ++Q ++G G FG VY+ V D + +A++E Sbjct: 1097 DDTTKENRLLKELASSKSNITIRWQQGGLIGSGSFGTVYR-AVNLDTGDLMAVKE----- 1150 Query: 335 VKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 V +H S + E++ L HPN+V G Sbjct: 1151 VALHKPRISRPMIKRIKGEMLVLELFDHPNVVSYYG 1186
>TIE2_BRARE (O73791) Tyrosine-protein kinase receptor Tie-2 precursor (EC| 2.7.10.1) Length = 1116 Score = 35.0 bits (79), Expect = 0.10 Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 1/81 (1%) Frame = +2 Query: 239 VLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLS- 415 VLG G FG+V K + D GL ++ AVK S HR++ E+ L +L Sbjct: 821 VLGEGNFGQVLKARIRKD---GLRMD----AAVKRMKDYASQDDHRDFAGELEVLCRLGP 873 Query: 416 HPNLVKLVGYCCEDDHRVLVY 478 H N++ L+G C +HR +Y Sbjct: 874 HKNIIHLLGAC---EHRGYLY 891
>FIN1_SCHPO (O13839) G2-specific protein kinase fin1 (EC 2.7.11.1)| Length = 722 Score = 35.0 bits (79), Expect = 0.10 Identities = 24/75 (32%), Positives = 39/75 (52%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 +G G FGR+YK L++G + + ++H G+ + Q + EV L L HP Sbjct: 10 IGHGSFGRIYK---VQRLKDGALLAQK-----EIHFGNITRQEKQYIADEVNILRNLKHP 61 Query: 422 NLVKLVGYCCEDDHR 466 N+V+ YC E+ +R Sbjct: 62 NIVQ---YCGEELNR 73
>ROR2_MOUSE (Q9Z138) Tyrosine-protein kinase transmembrane receptor ROR2| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2) Length = 944 Score = 35.0 bits (79), Expect = 0.10 Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 1/95 (1%) Frame = +2 Query: 197 EELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLR-VAVKVHDGDNSFQGH 373 +E+ T F ++ LG FG+VYKG + G A EP + VA+K Sbjct: 466 KEISLSTVRFMEE--LGEDRFGKVYKGHLF-----GPAPGEPTQAVAIKTLKDKAEGPLR 518 Query: 374 REWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 E+ E + +L HPN+V L+G +D +++ Sbjct: 519 EEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIF 553
>JAK_DROME (Q24592) Tyrosine-protein kinase hopscotch (EC 2.7.10.2)| Length = 1177 Score = 35.0 bits (79), Expect = 0.10 Identities = 28/103 (27%), Positives = 52/103 (50%) Frame = +2 Query: 167 RKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVH 346 R N L+ R+ N ++++G G +G VYKG + + ++ + +VA+K+ Sbjct: 875 RSNMLMVIPLTSECRVIYNM--ENMIGRGHYGTVYKGHLEFNDKD----QPREQVAIKML 928 Query: 347 DGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLV 475 N+ Q ++ E+ + LSHPN+VK Y E H +++ Sbjct: 929 ---NTMQVSTDFHREIGIMRTLSHPNIVKF-KYWAEKSHCIIM 967
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase| 1) (JAK-1) Length = 1153 Score = 35.0 bits (79), Expect = 0.10 Identities = 26/93 (27%), Positives = 44/93 (47%), Gaps = 5/93 (5%) Frame = +2 Query: 212 ITKNFRQDSVLGVGGFGRVYKGCVANDL-REGLAIEEPLRVAVKVHDGDNSFQGHRE--- 379 + K+ Q LG G +Y G + + EG+A E+ ++V +KV D HR+ Sbjct: 578 LKKDIIQGEHLGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLD-----PSHRDISL 632 Query: 380 -WLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLV 475 + + Q+SH ++V L G C D ++V Sbjct: 633 AFFEAASMMRQVSHKHIVYLYGVCVRDVENIMV 665 Score = 28.5 bits (62), Expect = 9.6 Identities = 28/85 (32%), Positives = 37/85 (43%), Gaps = 1/85 (1%) Frame = +2 Query: 206 KRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRV-AVKVHDGDNSFQGHREW 382 KR K R LG G FG+V + EG E + V ++K G N ++ Sbjct: 871 KRFLKRIRD---LGEGHFGKVE---LCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKK- 923 Query: 383 LAEVIFLGQLSHPNLVKLVGYCCED 457 E+ L L H N+VK G C ED Sbjct: 924 --EIEILRNLYHENIVKYKGICMED 946
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 35.0 bits (79), Expect = 0.10 Identities = 41/128 (32%), Positives = 51/128 (39%), Gaps = 2/128 (1%) Frame = +2 Query: 80 QSPSERIEKDD--SLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVG 253 Q PS R D L P N A+ +DS +P + KR K R LG G Sbjct: 848 QRPSFRTILRDLTRLQPQNLVGTSAVNSDSPASDPTVFH-----KRYLKKIRD---LGEG 899 Query: 254 GFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVK 433 FG+V C + +G VAVK Q W E+ L L H ++VK Sbjct: 900 HFGKVSLYCY-DPTNDGTGE----MVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVK 954 Query: 434 LVGYCCED 457 G CCED Sbjct: 955 YKG-CCED 961
>RON_MOUSE (Q62190) Macrophage-stimulating protein receptor precursor (EC| 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating prote Length = 1378 Score = 34.7 bits (78), Expect = 0.13 Identities = 30/106 (28%), Positives = 44/106 (41%), Gaps = 5/106 (4%) Frame = +2 Query: 140 VEALRNDSARKNPLIAFTFEELKRITKNFRQ-----DSVLGVGGFGRVYKGCVANDLREG 304 V LR +S R L E+K + Q D V+G G FG VY G + +G Sbjct: 1026 VPLLRTESIRLQDLDRMLLAEVKDVLIPHEQVVIHTDQVIGKGHFGVVYHG----EYTDG 1081 Query: 305 LAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + A+K Q +L E + + L HPN++ L+G Sbjct: 1082 A--QNQTHCAIKSLSRITEVQEVEAFLREGLLMRGLHHPNILALIG 1125
>SHARK_DROME (Q24145) Tyrosine-protein kinase shark (EC 2.7.10.2)| Length = 939 Score = 34.7 bits (78), Expect = 0.13 Identities = 22/70 (31%), Positives = 37/70 (52%) Frame = +2 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 D +G G FG V+ G + + G E L VA+K+ ++S +E+L E + +L Sbjct: 665 DREIGHGEFGSVHSGWLLR--KSGAGEESRLEVAIKMLSDEHS--NKQEFLREASVMMRL 720 Query: 413 SHPNLVKLVG 442 H +V+L+G Sbjct: 721 EHKCIVRLIG 730
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 34.7 bits (78), Expect = 0.13 Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 3/101 (2%) Frame = +2 Query: 182 IAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGD-- 355 +AF ELK + +G GGFG+VY+ A + VAVK D Sbjct: 119 VAFERLELKEL---------IGAGGFGQVYR-----------ATWQGQEVAVKAARQDPE 158 Query: 356 -NSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLV 475 ++ E L HPN+++L G C + H LV Sbjct: 159 QDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLV 199
>M3K1_MOUSE (P53349) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1493 Score = 34.3 bits (77), Expect = 0.17 Identities = 20/73 (27%), Positives = 39/73 (53%), Gaps = 2/73 (2%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREG--LAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLS 415 +G+G F Y+ A D+ G +A+++ V + + + RE E+ +G L+ Sbjct: 1230 IGLGAFSSCYQ---AQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALRE---EIRMMGHLN 1283 Query: 416 HPNLVKLVGYCCE 454 HPN+++++G CE Sbjct: 1284 HPNIIRMLGATCE 1296
>BUR1_YEAST (P23293) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) (Suppressor of GPA1-Vall50 mutation protein 1) (Bypass UAS requirement protein 1) Length = 657 Score = 34.3 bits (77), Expect = 0.17 Identities = 23/73 (31%), Positives = 38/73 (52%) Frame = +2 Query: 221 NFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 ++R+D LG G FG VYKG R+ +A++ ++ V V R E+ Sbjct: 59 HYREDEKLGQGTFGEVYKGIHLETQRQ-VAMK---KIIVSVEKDLFPITAQR----EITI 110 Query: 401 LGQLSHPNLVKLV 439 L +L+H N++KL+ Sbjct: 111 LKRLNHKNIIKLI 123
>YP141_YEAST (Q03002) Putative serine/threonine-protein kinase YPL141C (EC| 2.7.11.1) Length = 865 Score = 34.3 bits (77), Expect = 0.17 Identities = 25/71 (35%), Positives = 36/71 (50%), Gaps = 4/71 (5%) Frame = +2 Query: 236 SVLGVGGFGRVYKGCVAN-DLREGLAIEEPLRVAVKVHDGDNSFQGHREWLA---EVIFL 403 S LG G FG+V G N + P +VA+K+ D+ +R+ + E+ L Sbjct: 45 STLGEGEFGKVKLGWPKNFSNSSNSTFDFPKQVAIKLIKRDSISNDYRKEVKIYREINAL 104 Query: 404 GQLSHPNLVKL 436 LSHPN+VKL Sbjct: 105 KHLSHPNIVKL 115
>PR2_DROME (Q9I7F7) Tyrosine-protein kinase PR2 (EC 2.7.10.2)| Length = 1337 Score = 34.3 bits (77), Expect = 0.17 Identities = 23/78 (29%), Positives = 35/78 (44%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G FG V +G +N E ++VA+K + E+L E + + H Sbjct: 139 LGTGEFGIVQQGVWSNG-------NERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHE 191 Query: 422 NLVKLVGYCCEDDHRVLV 475 N+V+L G D +LV Sbjct: 192 NIVRLYGVVLATDSLMLV 209
>BUR1_KLULA (Q6CRA9) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 645 Score = 34.3 bits (77), Expect = 0.17 Identities = 26/84 (30%), Positives = 44/84 (52%), Gaps = 3/84 (3%) Frame = +2 Query: 197 EELKRITK---NFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQ 367 E++ +TK N+R++ LG G FG V+KG R+ +AI+ R+ V+ Sbjct: 43 EKVYGVTKFLNNYREEEKLGQGTFGEVFKGIHLGTNRK-VAIK---RILVRAEKDLFPIT 98 Query: 368 GHREWLAEVIFLGQLSHPNLVKLV 439 R E+ L +++H N+VKL+ Sbjct: 99 AQR----EITILKRMNHKNIVKLI 118
>ATG1_YEAST (P53104) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) (Autophagy protein 3) (Cytoplasm to vacuole targeting protein 10) Length = 897 Score = 34.3 bits (77), Expect = 0.17 Identities = 19/73 (26%), Positives = 37/73 (50%) Frame = +2 Query: 221 NFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 N+ + +G G F VY+G + +D + +AI+E R +K + + E+ Sbjct: 23 NYTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLE------IEIAI 76 Query: 401 LGQLSHPNLVKLV 439 L ++ HP++V L+ Sbjct: 77 LKKIKHPHIVGLI 89
>FLT3_HUMAN (P36888) FL cytokine receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen) Length = 993 Score = 33.9 bits (76), Expect = 0.23 Identities = 24/78 (30%), Positives = 37/78 (47%), Gaps = 1/78 (1%) Frame = +2 Query: 218 KNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVI 397 +N VLG G FG+V + G++I+ VAVK+ ++E+ Sbjct: 608 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQ----VAVKMLKEKADSSEREALMSELK 663 Query: 398 FLGQL-SHPNLVKLVGYC 448 + QL SH N+V L+G C Sbjct: 664 MMTQLGSHENIVNLLGAC 681
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 33.9 bits (76), Expect = 0.23 Identities = 23/73 (31%), Positives = 34/73 (46%), Gaps = 2/73 (2%) Frame = +2 Query: 242 LGVGGFGRVYKGCVA--NDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLS 415 +G G FG V+ G + N L + E L +K ++L E L Q S Sbjct: 222 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKA-----------KFLQEAKILKQYS 270 Query: 416 HPNLVKLVGYCCE 454 HPN+V+L+G C + Sbjct: 271 HPNIVRLIGVCTQ 283
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 33.9 bits (76), Expect = 0.23 Identities = 25/102 (24%), Positives = 49/102 (48%), Gaps = 3/102 (2%) Frame = +2 Query: 146 ALRNDSARKNPLIA---FTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIE 316 AL + +N L+ FT ++++ + + LG G FG+VYKG + + Sbjct: 388 ALNSKLIERNTLLRINHFTLQDVEFLEE-------LGEGAFGKVYKGQLLQPNK------ 434 Query: 317 EPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + VA+K + S + +++ E+ + L H N+V ++G Sbjct: 435 TTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCILG 476
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC| 2.7.10.2) (C-FES) Length = 820 Score = 33.9 bits (76), Expect = 0.23 Identities = 23/73 (31%), Positives = 34/73 (46%), Gaps = 2/73 (2%) Frame = +2 Query: 242 LGVGGFGRVYKGCVA--NDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLS 415 +G G FG V+ G + N L + E L +K ++L E L Q S Sbjct: 565 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKA-----------KFLQEAKILKQYS 613 Query: 416 HPNLVKLVGYCCE 454 HPN+V+L+G C + Sbjct: 614 HPNIVRLIGVCTQ 626
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 33.9 bits (76), Expect = 0.23 Identities = 23/93 (24%), Positives = 44/93 (47%), Gaps = 9/93 (9%) Frame = +2 Query: 191 TFEELKRITKNFRQD---------SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKV 343 T+EE R ++F ++ ++G G G V G R + + + VA+K Sbjct: 614 TYEEPGRAGRSFTREIEASRIHIEKIIGSGESGEVCYG------RLQVPGQRDVPVAIKA 667 Query: 344 HDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + + +++L+E +GQ HPN+++L G Sbjct: 668 LKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEG 700
>PTK7_HUMAN (Q13308) Tyrosine-protein kinase-like 7 precursor (Colon carcinoma| kinase 4) (CCK-4) Length = 1070 Score = 33.9 bits (76), Expect = 0.23 Identities = 25/80 (31%), Positives = 40/80 (50%) Frame = +2 Query: 236 SVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLS 415 + LG FG V+ A L EG+A E L + + D Q ++ E+ G+L+ Sbjct: 800 TTLGKSEFGEVFLA-KAQGLEEGVA--ETLVLVKSLQSKDE--QQQLDFRRELEMFGKLN 854 Query: 416 HPNLVKLVGYCCEDDHRVLV 475 H N+V+L+G C E + +V Sbjct: 855 HANVVRLLGLCREAEPHYMV 874
>FES_FSVGA (P00542) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 609 Score = 33.9 bits (76), Expect = 0.23 Identities = 23/73 (31%), Positives = 34/73 (46%), Gaps = 2/73 (2%) Frame = +2 Query: 242 LGVGGFGRVYKGCVA--NDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLS 415 +G G FG V+ G + N L + E L +K ++L E L Q S Sbjct: 354 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKA-----------KFLQEAKILKQYS 402 Query: 416 HPNLVKLVGYCCE 454 HPN+V+L+G C + Sbjct: 403 HPNIVRLIGVCTQ 415
>YS3J_CAEEL (Q19238) Putative tyrosine-protein kinase F09A5.2 in chromosome X| (EC 2.7.10.1) Length = 894 Score = 33.9 bits (76), Expect = 0.23 Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 14/101 (13%) Frame = +2 Query: 215 TKNF--RQDSVLGVGGFGRVYKGCVA---------NDLREGLAIEE--PLRVAVKVHDGD 355 TKN ++D +LG G F VYKG V N L + E A+K Sbjct: 459 TKNLLVQEDHLLGNGAFANVYKGIVKGKIPLLVVNNSLNMTVESENNGHYEAAIKKLPAH 518 Query: 356 NSFQGHREWLAEVIFLGQLS-HPNLVKLVGYCCEDDHRVLV 475 Q H ++ E+ F+ +L HP+++ ++G C + + L+ Sbjct: 519 ADEQNHLDFFHEIDFMKRLGHHPHVISMLG-CVSNPYEPLI 558
>VIT1_FUNHE (Q90508) Vitellogenin-1 precursor (Vitellogenin I) (VTG I) [Contains:| Lipovitellin-1 (LV1); Phosvitin (PV); Lipovitellin-2 (LV2)] Length = 1704 Score = 33.5 bits (75), Expect = 0.30 Identities = 25/78 (32%), Positives = 36/78 (46%), Gaps = 1/78 (1%) Frame = -3 Query: 333 ATRSGSSIANPSRRSXXXXXXXXXXXXXXPSTESCLKFLVILLSSSNVNAIRGFLRAESL 154 A R+ SS ++ SRRS S+ S + SSS+ ++ R R S Sbjct: 1117 AARTNSSSSSSSRRSRSSSSSSSSSSSSSSSSSSSSRRSSSSSSSSSSSSSRSSRRVNST 1176 Query: 153 R-SASTSRGLDGSRLSSF 103 R S+S+SR S L+SF Sbjct: 1177 RSSSSSSRTSSASSLASF 1194
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase| 1) (JAK-1) Length = 1142 Score = 33.5 bits (75), Expect = 0.30 Identities = 27/105 (25%), Positives = 49/105 (46%), Gaps = 5/105 (4%) Frame = +2 Query: 176 PLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLR-EGLAIEEPLRVAVKVHDG 352 P+ +F+ + + K+ Q LG G +Y G + + EG + E+ ++V +KV D Sbjct: 557 PMSQLSFDRI--LKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLD- 613 Query: 353 DNSFQGHRE----WLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLV 475 HR+ + + Q+SH ++V L G C D ++V Sbjct: 614 ----PSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMV 654 Score = 29.6 bits (65), Expect = 4.3 Identities = 34/116 (29%), Positives = 46/116 (39%) Frame = +2 Query: 110 DSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVAN 289 + L NP V +N +P FE KR K R LG G FG+V Sbjct: 834 NKLEEQNPDIVSRKKNQPTEVDPT---HFE--KRFLKRIRD---LGEGHFGKVELCRYDP 885 Query: 290 DLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCED 457 + G E+ ++K G N ++ E+ L L H N+VK G C ED Sbjct: 886 EDNTG---EQVAVKSLKPESGGNHIADLKK---EIEILRNLYHENIVKYKGICTED 935
>WEE1_RAT (Q63802) Wee1-like protein kinase (EC 2.7.10.2)| Length = 646 Score = 33.5 bits (75), Expect = 0.30 Identities = 35/112 (31%), Positives = 50/112 (44%), Gaps = 7/112 (6%) Frame = +2 Query: 158 DSARKNPLIAFTFEELK-RITKNFRQDSVLGVGGFGRVYK------GCVANDLREGLAIE 316 D R I T +K R T F + +G G FG V+K GC+ R + Sbjct: 275 DETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRS----K 330 Query: 317 EPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVL 472 +PL +V D N+ RE A + LGQ HP++V+ EDDH ++ Sbjct: 331 KPLAGSV---DEQNAL---REVYAHAV-LGQ--HPHVVRYFSAWAEDDHMLI 373
>WEE1_MOUSE (P47810) Wee1-like protein kinase (EC 2.7.10.2)| Length = 646 Score = 33.5 bits (75), Expect = 0.30 Identities = 35/112 (31%), Positives = 50/112 (44%), Gaps = 7/112 (6%) Frame = +2 Query: 158 DSARKNPLIAFTFEELK-RITKNFRQDSVLGVGGFGRVYK------GCVANDLREGLAIE 316 D R I T +K R T F + +G G FG V+K GC+ R + Sbjct: 275 DETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRS----K 330 Query: 317 EPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVL 472 +PL +V D N+ RE A + LGQ HP++V+ EDDH ++ Sbjct: 331 KPLAGSV---DEQNAL---REVYAHAV-LGQ--HPHVVRYFSAWAEDDHMLI 373
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 33.5 bits (75), Expect = 0.30 Identities = 23/85 (27%), Positives = 37/85 (43%) Frame = +2 Query: 206 KRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWL 385 KRI+ ++ V+G GG VY L E + ++ + + + D N + R + Sbjct: 5 KRISGRYQILRVIGGGGMANVY-------LAEDIILDREVAIKILRFDYANDNEFIRRFR 57 Query: 386 AEVIFLGQLSHPNLVKLVGYCCEDD 460 E L HPN+V + EDD Sbjct: 58 REAQSASSLDHPNIVSIYDLGEEDD 82
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 33.5 bits (75), Expect = 0.30 Identities = 20/88 (22%), Positives = 43/88 (48%) Frame = +2 Query: 215 TKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEV 394 T+N V+G G G +YK ++ D + A+++ + +K G + E+ Sbjct: 813 TENLNDKYVIGKGAHGTIYKATLSPD--KVYAVKKLVFTGIK--------NGSVSMVREI 862 Query: 395 IFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 +G++ H NL+KL + ++ +++Y Sbjct: 863 ETIGKVRHRNLIKLEEFWLRKEYGLILY 890
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 33.5 bits (75), Expect = 0.30 Identities = 39/153 (25%), Positives = 70/153 (45%), Gaps = 16/153 (10%) Frame = +2 Query: 59 VAESPKLQSPSERI-----EKDDSLLPSNPR--EVEALRNDSARKNPLIAFTFEELKRIT 217 ++ SP+ ++P+ +I EK + L +N + ++E+ + S + + E K++ Sbjct: 35 ISHSPQQRNPNSKIPSPVREKLNRLPVNNKKFLDMESSKIPSPIRKATSSKMIHENKKLP 94 Query: 218 K-------NFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDN--SFQG 370 K +F LG G FG+VY CV + + A+KV + + + Sbjct: 95 KFKSLSLDDFELGKKLGKGKFGKVY--CVRHRSTGYIC-------ALKVMEKEEIIKYNL 145 Query: 371 HREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRV 469 +++ EV L+HPNL K GY D+ RV Sbjct: 146 QKQFRREVEIQTSLNHPNLTKSYGY-FHDEKRV 177
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 33.5 bits (75), Expect = 0.30 Identities = 24/69 (34%), Positives = 32/69 (46%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G +G VY G + L VAVK D E+L E + ++ HP Sbjct: 294 LGGGQYGEVYVGVWK---------KYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 342 Query: 422 NLVKLVGYC 448 NLV+L+G C Sbjct: 343 NLVQLLGVC 351
>E2AK1_SCHPO (O13889) Eukaryotic translation initiation factor 2-alpha kinase 1| (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor 1) Length = 704 Score = 33.5 bits (75), Expect = 0.30 Identities = 24/83 (28%), Positives = 37/83 (44%) Frame = +2 Query: 185 AFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSF 364 +F + R +F + +LG GG+G VYK D E + PLR+ SF Sbjct: 211 SFPTVQRSRYASDFEELELLGKGGYGSVYKARNKFDGVEYALKKIPLRL--------RSF 262 Query: 365 QGHREWLAEVIFLGQLSHPNLVK 433 E L +L+HPN+++ Sbjct: 263 STSSNIFRESRTLARLNHPNVIR 285
>BUR1_CANGA (Q6FQ83) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 667 Score = 33.5 bits (75), Expect = 0.30 Identities = 23/76 (30%), Positives = 41/76 (53%), Gaps = 3/76 (3%) Frame = +2 Query: 221 NFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVK---VHDGDNSFQGHREWLAE 391 N++++ LG G FG VYK GL ++ +VA+K V+ ++ F + E Sbjct: 59 NYKEEEKLGQGTFGEVYK---------GLHLQTQRKVAMKRIIVNQENDLFPITAQ--RE 107 Query: 392 VIFLGQLSHPNLVKLV 439 + L +L+H N++KL+ Sbjct: 108 ITILKRLNHKNIIKLL 123
>FES_HUMAN (P07332) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 822 Score = 33.1 bits (74), Expect = 0.39 Identities = 23/73 (31%), Positives = 34/73 (46%), Gaps = 2/73 (2%) Frame = +2 Query: 242 LGVGGFGRVYKGCVA--NDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLS 415 +G G FG V+ G + N L + E L +K ++L E L Q S Sbjct: 567 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKA-----------KFLQEARILKQYS 615 Query: 416 HPNLVKLVGYCCE 454 HPN+V+L+G C + Sbjct: 616 HPNIVRLIGVCTQ 628
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 33.1 bits (74), Expect = 0.39 Identities = 25/91 (27%), Positives = 42/91 (46%) Frame = +2 Query: 203 LKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREW 382 +K + +F + + L GGFG+V + +GL I + V+ G N + + Sbjct: 10 IKMKSSDFLESAELDSGGFGKV---SLCFHRTQGLMIMK------TVYKGPNCIEHNEAL 60 Query: 383 LAEVIFLGQLSHPNLVKLVGYCCEDDHRVLV 475 L E + +L H +VKL+G E+ LV Sbjct: 61 LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLV 91
>HTK7_HYDAT (Q25197) Putative insulin-like peptide receptor precursor (EC| 2.7.10.1) Length = 1477 Score = 32.7 bits (73), Expect = 0.51 Identities = 21/67 (31%), Positives = 33/67 (49%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G FG V++G + G+ LRVAVK + + S + L E + + Sbjct: 1050 LGQGSFGMVFEG-----IAHGIGDHAELRVAVKTTNENASIHDRIQILQEASIMKAFNCN 1104 Query: 422 NLVKLVG 442 ++VKL+G Sbjct: 1105 HVVKLIG 1111
>SEA_AVIET (P23049) Tyrosine-protein kinase transforming protein SEA (EC| 2.7.10.2) Length = 370 Score = 32.7 bits (73), Expect = 0.51 Identities = 36/134 (26%), Positives = 48/134 (35%), Gaps = 5/134 (3%) Frame = +2 Query: 62 AESPKLQSPSERIEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKN-----F 226 A+SP L P + V LR S L EE+K I Sbjct: 1 ADSPGLARPHAHFASAGADAAGGGSPVLLLRTTSCCLEDLRPELLEEVKDILIPEERLIT 60 Query: 227 RQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLG 406 + V+G G FG VY G + L L AVK + E+L E I + Sbjct: 61 HRSRVIGRGHFGSVYHGTYMDPLLGNL------HCAVKSLHRITYLEEVEEFLREGILMK 114 Query: 407 QLSHPNLVKLVGYC 448 HP ++ L+G C Sbjct: 115 GFHHPQVLSLLGVC 128
>ROR1_HUMAN (Q01973) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) Length = 937 Score = 32.7 bits (73), Expect = 0.51 Identities = 21/67 (31%), Positives = 33/67 (49%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG FG++YKG + ++ VA+K N+ Q E+ E + +L HP Sbjct: 479 LGECAFGKIYKGHLYLP-----GMDHAQLVAIKTLKDYNNPQQWMEFQQEASLMAELHHP 533 Query: 422 NLVKLVG 442 N+V L+G Sbjct: 534 NIVCLLG 540
>IGF1R_MOUSE (Q60751) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1373 Score = 32.7 bits (73), Expect = 0.51 Identities = 22/68 (32%), Positives = 38/68 (55%), Gaps = 1/68 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEP-LRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 LG G FG VY+G + +G+ +EP RVA+K + S + E+L E + + + Sbjct: 1006 LGQGSFGMVYEG-----VAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNC 1060 Query: 419 PNLVKLVG 442 ++V+L+G Sbjct: 1061 HHVVRLLG 1068
>IGF1R_BOVIN (Q05688) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (F Length = 640 Score = 32.7 bits (73), Expect = 0.51 Identities = 22/68 (32%), Positives = 38/68 (55%), Gaps = 1/68 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEP-LRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 LG G FG VY+G + +G+ +EP RVA+K + S + E+L E + + + Sbjct: 278 LGQGSFGMVYEG-----VAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNC 332 Query: 419 PNLVKLVG 442 ++V+L+G Sbjct: 333 HHVVRLLG 340
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 32.7 bits (73), Expect = 0.51 Identities = 37/144 (25%), Positives = 55/144 (38%) Frame = +2 Query: 47 ATKSVAESPKLQSPSERIEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNF 226 +T S A S S SE IE +L FEE+ K Sbjct: 2 STASAASSSSSSSASEMIEAPSQVL-----------------------NFEEIDY--KEI 36 Query: 227 RQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLG 406 + V+G G FG V K A VA+K + ++ + ++ E+ L Sbjct: 37 EVEEVVGRGAFGVVCK-----------AKWRAKDVAIKQIESESE---RKAFIVELRQLS 82 Query: 407 QLSHPNLVKLVGYCCEDDHRVLVY 478 +++HPN+VKL G C V+ Y Sbjct: 83 RVNHPNIVKLYGACLNPVCLVMEY 106
>IGF1R_HUMAN (P08069) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 recepto Length = 1367 Score = 32.7 bits (73), Expect = 0.51 Identities = 22/68 (32%), Positives = 38/68 (55%), Gaps = 1/68 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEP-LRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 LG G FG VY+G + +G+ +EP RVA+K + S + E+L E + + + Sbjct: 1005 LGQGSFGMVYEG-----VAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNC 1059 Query: 419 PNLVKLVG 442 ++V+L+G Sbjct: 1060 HHVVRLLG 1067
>IGF1R_RAT (P24062) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1370 Score = 32.7 bits (73), Expect = 0.51 Identities = 22/68 (32%), Positives = 38/68 (55%), Gaps = 1/68 (1%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEP-LRVAVKVHDGDNSFQGHREWLAEVIFLGQLSH 418 LG G FG VY+G + +G+ +EP RVA+K + S + E+L E + + + Sbjct: 1006 LGQGSFGMVYEG-----VAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNC 1060 Query: 419 PNLVKLVG 442 ++V+L+G Sbjct: 1061 HHVVRLLG 1068
>NEK7_MOUSE (Q9ES74) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 32.7 bits (73), Expect = 0.51 Identities = 24/85 (28%), Positives = 44/85 (51%) Frame = +2 Query: 221 NFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIF 400 NFR + +G G F VY+ A+ L +G+ + V++ D ++ + + + E+ Sbjct: 33 NFRIEKKIGRGQFSEVYR---ASCLLDGVPVALK---KVQIFDLMDA-KARADCIKEIDL 85 Query: 401 LGQLSHPNLVKLVGYCCEDDHRVLV 475 L QL+HPN++K ED+ +V Sbjct: 86 LKQLNHPNVIKYYASFIEDNELNIV 110
>MURG_LACLA (Q9CF92) UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide)| pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase) Length = 357 Score = 32.7 bits (73), Expect = 0.51 Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 4/82 (4%) Frame = +2 Query: 137 EVEALRNDSARKNPLIAFTF----EELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREG 304 +++ LR + +N A+ F + K+I K F+ D VLG GG+ VA + Sbjct: 58 DIQGLRRSLSPQNLKTAYKFFKSVSDAKKIMKEFKPDVVLGTGGY-------VAGPVVYA 110 Query: 305 LAIEEPLRVAVKVHDGDNSFQG 370 A L++ +H+G NSF G Sbjct: 111 AA---QLKIPTIIHEG-NSFPG 128
>E2AK1_HUMAN (Q9BQI3) Eukaryotic translation initiation factor 2-alpha kinase 1| (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor Length = 630 Score = 32.7 bits (73), Expect = 0.51 Identities = 37/125 (29%), Positives = 56/125 (44%), Gaps = 7/125 (5%) Frame = +2 Query: 77 LQSPSERIEKDDSLLPSNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGG 256 ++S ER+ +D ++ ++ +R+ L A T R F + ++LG GG Sbjct: 128 MRSAKERVRQDPC------EDISRIQKIRSREVALEAQT----SRYLNEFEELAILGKGG 177 Query: 257 FGRVYKGCVANDL-REGLAIEEPL------RVAVKVHDGDNSFQGHREWLAEVIFLGQLS 415 +GRVYK V N L + AI++ L V +KV L EV L L Sbjct: 178 YGRVYK--VRNKLDGQYYAIKKILIKGATKTVCMKV-------------LREVKVLAGLQ 222 Query: 416 HPNLV 430 HPN+V Sbjct: 223 HPNIV 227
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 32.7 bits (73), Expect = 0.51 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 4/88 (4%) Frame = +2 Query: 227 RQDSVL----GVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEV 394 RQD +L G G FG+V+ N L + ++ + VAVK + S +++ E Sbjct: 510 RQDIILKWELGEGAFGKVFLAECYNLLND----QDKMLVAVKALK-ETSENARQDFHREA 564 Query: 395 IFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 L L H ++V+ G C E ++V+ Sbjct: 565 ELLTMLQHQHIVRFFGVCTEGGPLLMVF 592
>CDK4_XENLA (Q91727) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 319 Score = 32.7 bits (73), Expect = 0.51 Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 5/86 (5%) Frame = +2 Query: 206 KRITKNFRQDSVLGVGGFGRVYKGCVANDLREG--LAIEEPLRVAVKVHDGDNSFQGHRE 379 K + + + +GVG +G VYK A DL+ G +A++ V+V +N Sbjct: 3 KEMKGQYEPVAEIGVGAYGTVYK---ARDLQSGKFVALKN-----VRVQTNENGLP--LS 52 Query: 380 WLAEVIFLGQLSH---PNLVKLVGYC 448 + EV L +L H PN+VKL+ C Sbjct: 53 TVREVTLLKRLEHFDHPNIVKLMDVC 78
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 32.3 bits (72), Expect = 0.66 Identities = 22/72 (30%), Positives = 33/72 (45%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 LG G +G VY E + VAVK D +++L E + ++ HP Sbjct: 377 LGGGQYGEVY---------EAVWKRYGNTVAVKTLKEDT--MALKDFLEEAAIMKEMKHP 425 Query: 422 NLVKLVGYCCED 457 NLV+L+G C + Sbjct: 426 NLVQLIGVCTRE 437
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 32.3 bits (72), Expect = 0.66 Identities = 22/71 (30%), Positives = 33/71 (46%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 +G G FG V+ G + D VAVK + ++L E L Q +HP Sbjct: 278 IGRGNFGEVFSGRLRADNTP---------VAVKSCRETLPPELKAKFLQEARILKQYNHP 328 Query: 422 NLVKLVGYCCE 454 N+V+L+G C + Sbjct: 329 NIVRLIGVCTQ 339
>ZAP70_HUMAN (P43403) Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa| zeta-associated protein) (Syk-related tyrosine kinase) Length = 619 Score = 32.3 bits (72), Expect = 0.66 Identities = 29/108 (26%), Positives = 44/108 (40%) Frame = +2 Query: 125 SNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREG 304 S+P E++ + R N LIA D LG G FG V +G ++ Sbjct: 320 SDPEELKDKKLFLKRDNLLIA---------------DIELGCGNFGSVRQGVYRMRKKQ- 363 Query: 305 LAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYC 448 + VA+KV E + E + QL +P +V+L+G C Sbjct: 364 ------IDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC 405
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 32.3 bits (72), Expect = 0.66 Identities = 28/101 (27%), Positives = 44/101 (43%) Frame = +2 Query: 176 PLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGD 355 P FEE+ K + V+G G FG V K A VA+K + + Sbjct: 22 PSQVLNFEEIDY--KEIEVEEVVGRGAFGVVCK-----------AKWRAKDVAIKQIESE 68 Query: 356 NSFQGHREWLAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 + + ++ E+ L +++HPN+VKL G C V+ Y Sbjct: 69 SE---RKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEY 106
>E2AK1_MOUSE (Q9Z2R9) Eukaryotic translation initiation factor 2-alpha kinase 1| (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor Length = 619 Score = 32.3 bits (72), Expect = 0.66 Identities = 33/104 (31%), Positives = 47/104 (45%), Gaps = 8/104 (7%) Frame = +2 Query: 143 EALRNDSARKNPLIA------FTFE-ELKRITKNFRQDSVLGVGGFGRVYKGCVANDL-R 298 E +R D + N + FE + R F + ++LG GG+GRVYK V N L Sbjct: 133 ERVRQDPCQDNSYMQKIRSREIAFEAQTSRYLNEFEELAILGKGGYGRVYK--VRNKLDG 190 Query: 299 EGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLV 430 + AI++ L + D + L EV L L HPN+V Sbjct: 191 QHYAIKKILIKSATKTD-------CMKVLREVKVLAGLQHPNIV 227
>ZAP70_MOUSE (P43404) Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa| zeta-associated protein) (Syk-related tyrosine kinase) Length = 618 Score = 32.3 bits (72), Expect = 0.66 Identities = 28/108 (25%), Positives = 45/108 (41%) Frame = +2 Query: 125 SNPREVEALRNDSARKNPLIAFTFEELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREG 304 S+P E++ + R+N L+A D LG G FG V +G ++ Sbjct: 319 SDPEELKDKKLFLKRENLLVA---------------DIELGCGNFGSVRQGVYRMRKKQ- 362 Query: 305 LAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVGYC 448 + VA+KV E + E + QL +P +V+L+G C Sbjct: 363 ------IDVAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIGVC 404
>RON_HUMAN (Q04912) Macrophage-stimulating protein receptor precursor (EC| 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] Length = 1400 Score = 32.3 bits (72), Expect = 0.66 Identities = 27/106 (25%), Positives = 46/106 (43%), Gaps = 5/106 (4%) Frame = +2 Query: 140 VEALRNDSARKNPLIAFTFEELKRITKNFRQ-----DSVLGVGGFGRVYKGCVANDLREG 304 V LR +S + L + E+K + + D V+G G FG VY G + Sbjct: 1049 VPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQA--- 1105 Query: 305 LAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 + ++ A+K Q +L E + + L+HPN++ L+G Sbjct: 1106 ---QNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIG 1148
>TAOK3_MOUSE (Q8BYC6) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 32.3 bits (72), Expect = 0.66 Identities = 23/74 (31%), Positives = 34/74 (45%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 +G G FG VY A+ E + V + G + + ++ L EV FL QL HP Sbjct: 30 IGHGSFGAVYFATNAHT-------NEVVAVKKMSYSGKQTHEKWQDILKEVKFLQQLKHP 82 Query: 422 NLVKLVGYCCEDDH 463 N ++ G C +H Sbjct: 83 NTIEYKG-CYLKEH 95
>ROR1_MOUSE (Q9Z139) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1) Length = 937 Score = 32.3 bits (72), Expect = 0.66 Identities = 29/111 (26%), Positives = 50/111 (45%), Gaps = 4/111 (3%) Frame = +2 Query: 122 PSNPREVEALRNDSARKNPLIAFT----FEELKRITKNFRQDSVLGVGGFGRVYKGCVAN 289 P R+ + +R + + L A+ +EL F ++ LG FG++YKG + Sbjct: 437 PPVQRQPKPVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEE--LGECTFGKIYKGHLYL 494 Query: 290 DLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHPNLVKLVG 442 ++ VA+K N+ Q E+ E + +L HPN+V L+G Sbjct: 495 P-----GMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLG 540
>E2AK1_RABIT (P33279) Eukaryotic translation initiation factor 2-alpha kinase 1| (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor Length = 626 Score = 32.3 bits (72), Expect = 0.66 Identities = 28/78 (35%), Positives = 37/78 (47%), Gaps = 1/78 (1%) Frame = +2 Query: 200 ELKRITKNFRQDSVLGVGGFGRVYKGCVANDL-REGLAIEEPLRVAVKVHDGDNSFQGHR 376 + R F + S+LG GG+GRVYK V N L + AI++ L D Sbjct: 162 QTSRYLNEFEELSILGKGGYGRVYK--VRNKLDGQYYAIKKILIKGATKTD-------CM 212 Query: 377 EWLAEVIFLGQLSHPNLV 430 + L EV L L HPN+V Sbjct: 213 KVLREVKVLAGLQHPNIV 230
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 32.3 bits (72), Expect = 0.66 Identities = 24/84 (28%), Positives = 35/84 (41%) Frame = +2 Query: 224 FRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFL 403 FR LG GG G VY G E +++ + + V HD + E L Sbjct: 13 FRVLRPLGSGGMGEVYLG-------EQVSLGRKVAIKVLHHDLHAQAGMAERFKREARLL 65 Query: 404 GQLSHPNLVKLVGYCCEDDHRVLV 475 + HP +V++V + DH LV Sbjct: 66 SAVEHPAVVRIVDFGESGDHACLV 89
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 32.3 bits (72), Expect = 0.66 Identities = 22/71 (30%), Positives = 33/71 (46%) Frame = +2 Query: 242 LGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQLSHP 421 +G G FG V+ G + D VAVK + ++L E L Q +HP Sbjct: 618 IGRGNFGEVFSGRLRADNTP---------VAVKSCRETLPPELKAKFLQEARILKQCNHP 668 Query: 422 NLVKLVGYCCE 454 N+V+L+G C + Sbjct: 669 NIVRLIGVCTQ 679
>CDK7_XENLA (P20911) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (40 kDa protein kinase) (P40 MO15) (CDC2/CDK2,4-activating kinase) Length = 352 Score = 32.3 bits (72), Expect = 0.66 Identities = 24/80 (30%), Positives = 37/80 (46%) Frame = +2 Query: 200 ELKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHRE 379 +++ K + + LG G F VYK N R + L + +DG N R Sbjct: 10 DVRSRAKQYEKLDFLGEGQFATVYKARDKNTDRIVAIKKIKLGHRAEANDGIN-----RT 64 Query: 380 WLAEVIFLGQLSHPNLVKLV 439 L E+ L +LSHPN++ L+ Sbjct: 65 ALREIKLLQELSHPNIIGLL 84
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 32.3 bits (72), Expect = 0.66 Identities = 36/131 (27%), Positives = 60/131 (45%), Gaps = 5/131 (3%) Frame = +2 Query: 68 SPKLQSPSERIEKDDSLLPSNPREVE---ALRNDSARKNPLIAFTFEELKR--ITKNFRQ 232 +PK Q P+ + + S L +NP++ E A NDS ++ + T + KR ++F Sbjct: 69 APK-QLPAASVPRPVSRL-NNPQKNEQPAASGNDSEKEQASLQKTEDTKKRQWTLEDFDI 126 Query: 233 DSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREWLAEVIFLGQL 412 LG G FG VY +A + + + + ++ + Q RE V L Sbjct: 127 GRPLGKGKFGNVY---LARERQSKFILALKVLFKTQLEKANVEHQLRRE----VEIQSHL 179 Query: 413 SHPNLVKLVGY 445 HPN+++L GY Sbjct: 180 RHPNILRLYGY 190
>CC2H3_TRYBB (P54666) Cell division control protein 2 homolog 3 (EC 2.7.11.22)| Length = 311 Score = 32.3 bits (72), Expect = 0.66 Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 1/93 (1%) Frame = +2 Query: 203 LKRITKNFRQDSVLGVGGFGRVYKGCVANDLREGLAIEEPLRVAVKVHDGDNSFQGHREW 382 LK + + +LG G +G VY+ A D G VA+K D + +G + Sbjct: 16 LKDQFDRYNRMDILGEGTYGVVYR---AVDRATGQI------VALKKVRLDRTDEGIPQT 66 Query: 383 -LAEVIFLGQLSHPNLVKLVGYCCEDDHRVLVY 478 L EV L ++ HPN+V L+ C D L++ Sbjct: 67 ALREVSILQEIHHPNIVNLLDVICADGKLYLIF 99 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 70,849,074 Number of Sequences: 219361 Number of extensions: 1492298 Number of successful extensions: 6814 Number of sequences better than 10.0: 412 Number of HSP's better than 10.0 without gapping: 6303 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6648 length of database: 80,573,946 effective HSP length: 103 effective length of database: 57,979,763 effective search space used: 3246866728 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
