ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bah63a17 |
|---|---|
| Clone Library Name | barley_pub |
>MPK3_ARATH (Q39023) Mitogen-activated protein kinase homolog 3 (EC 2.7.11.24)| (MAP kinase 3) (AtMPK3) Length = 370 Score = 301 bits (772), Expect = 6e-82 Identities = 139/167 (83%), Positives = 156/167 (93%) Frame = +1 Query: 25 ASEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA 204 A V+PP + + F+DVYI+TELMDTDLH IIRSNQ LSEEHCQYFLYQLLRGLKYIHSA Sbjct: 99 AIRDVVPPPLRRQFSDVYISTELMDTDLHQIIRSNQSLSEEHCQYFLYQLLRGLKYIHSA 158 Query: 205 NVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSA 384 N+IHRDLKPSNLLLNANCDLKICDFGLARP+SE+D MTEYVVTRWYRAPELLLNS+DY+A Sbjct: 159 NIIHRDLKPSNLLLNANCDLKICDFGLARPTSENDFMTEYVVTRWYRAPELLLNSSDYTA 218 Query: 385 AIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGF 525 AIDVWSVGCIFMEL+NR PLFPG+DH+HQMRL+TE++GTPT+ DLGF Sbjct: 219 AIDVWSVGCIFMELMNRKPLFPGKDHVHQMRLLTELLGTPTESDLGF 265
>MMK1_MEDSA (Q07176) Mitogen-activated protein kinase homolog MMK1 (EC| 2.7.11.24) (MAP kinase MSK7) (MAP kinase ERK1) Length = 387 Score = 292 bits (748), Expect = 3e-79 Identities = 136/168 (80%), Positives = 154/168 (91%) Frame = +1 Query: 25 ASEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA 204 A ++PP + FNDVYIA ELMDTDLH IIRSNQ LSEEHCQYFLYQ+LRGLKYIHSA Sbjct: 116 AIRDIVPPPQREVFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 175 Query: 205 NVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSA 384 NV+HRDLKPSNLLLNANCDLKICDFGLAR +SE+D MTEYVVTRWYRAPELLLNS+DY+A Sbjct: 176 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSETDFMTEYVVTRWYRAPELLLNSSDYTA 235 Query: 385 AIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 AIDVWSVGCIFMEL++R PLFPGRDH+HQ+RL+ E+IGTP++DDLGF+ Sbjct: 236 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEDDLGFL 283
>MPK6_ARATH (Q39026) Mitogen-activated protein kinase homolog 6 (EC 2.7.11.24)| (MAP kinase 6) (AtMPK6) Length = 395 Score = 290 bits (742), Expect = 2e-78 Identities = 135/168 (80%), Positives = 154/168 (91%) Frame = +1 Query: 25 ASEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA 204 A +IPP + +FNDVYIA ELMDTDLH IIRSNQ LSEEHCQYFLYQ+LRGLKYIHSA Sbjct: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 Query: 205 NVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSA 384 NV+HRDLKPSNLLLNANCDLKICDFGLAR +SESD MTEYVVTRWYRAPELLLNS+DY+A Sbjct: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 Query: 385 AIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 AIDVWSVGCIFMEL++R PLFPGRDH+HQ+RL+ E+IGTP++++L F+ Sbjct: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291
>MAPK_PEA (Q06060) Mitogen-activated protein kinase homolog D5 (EC 2.7.11.24)| Length = 394 Score = 289 bits (740), Expect = 3e-78 Identities = 135/168 (80%), Positives = 153/168 (91%) Frame = +1 Query: 25 ASEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA 204 A ++PP + FNDVYIA ELMDTDLH IIRSNQ LSEEHCQYFLYQ+LRGLKYIHSA Sbjct: 123 AIRDIVPPPQREVFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 182 Query: 205 NVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSA 384 NV+HRDLKPSNLLLNANCDLKICDFGLAR +SE+D MTEYVVTRWYRAPELLLNS+DY+A Sbjct: 183 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSETDFMTEYVVTRWYRAPELLLNSSDYTA 242 Query: 385 AIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 AIDVWSVGCIFMEL++R PLFPGRDH+HQ+RL+ E+IGTP++ DLGF+ Sbjct: 243 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEADLGFL 290
>NTF4_TOBAC (Q40532) Mitogen-activated protein kinase homolog NTF4 (EC| 2.7.11.24) (P45) Length = 393 Score = 285 bits (729), Expect = 5e-77 Identities = 133/168 (79%), Positives = 153/168 (91%) Frame = +1 Query: 25 ASEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA 204 A +IPP ++FNDVYIA ELMDTDLH IIRSNQ LSEEHCQYFLYQ+LRGLKYIHSA Sbjct: 121 AIRDIIPPPQREAFNDVYIAYELMDTDLHQIIRSNQGLSEEHCQYFLYQILRGLKYIHSA 180 Query: 205 NVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSA 384 NV+HRDLKPSNLLLNANCDLKICDFGLAR +SE+D MTEYVVTRWYRAPELLLNS+DY+A Sbjct: 181 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSETDFMTEYVVTRWYRAPELLLNSSDYTA 240 Query: 385 AIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 AIDVWSVGCIFMEL++R PLFPGRDH+HQ+RL+ E+IGTP++ ++ F+ Sbjct: 241 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEAEMEFL 288
>NTF6_TOBAC (Q40531) Mitogen-activated protein kinase homolog NTF6 (EC| 2.7.11.24) (P43) Length = 371 Score = 267 bits (682), Expect = 2e-71 Identities = 123/165 (74%), Positives = 143/165 (86%) Frame = +1 Query: 37 VIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIH 216 ++ P + FNDVYI ELMDTDLH IIRS+Q L+++HCQYFLYQLLRGLKY+HSANV+H Sbjct: 103 IVRPPDREEFNDVYIVYELMDTDLHQIIRSSQALTDDHCQYFLYQLLRGLKYVHSANVLH 162 Query: 217 RDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDV 396 RDLKPSNLLLNANCDLKICDFGLAR +SE+D MTEYVVTRWYRAPELLLN T+Y+AAID+ Sbjct: 163 RDLKPSNLLLNANCDLKICDFGLARTTSEADFMTEYVVTRWYRAPELLLNCTEYTAAIDI 222 Query: 397 WSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFIR 531 WSVGCI MELI R PLFPGRD+ Q+ LI ++G+P D DLGF+R Sbjct: 223 WSVGCILMELIKREPLFPGRDYAQQLGLIIALLGSPEDSDLGFLR 267
>MMK2_MEDSA (Q40353) Mitogen-activated protein kinase homolog MMK2 (EC| 2.7.11.24) Length = 371 Score = 265 bits (676), Expect = 8e-71 Identities = 120/165 (72%), Positives = 146/165 (88%) Frame = +1 Query: 37 VIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIH 216 +I P ++FN VYI +ELMDTDLH IIRSNQ ++++HC+YF+YQLLRGLKY+HSANV+H Sbjct: 102 IIRPPQKENFNHVYIVSELMDTDLHQIIRSNQPMTDDHCRYFVYQLLRGLKYVHSANVLH 161 Query: 217 RDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDV 396 RDLKPSNLLLNANCDLKI DFGLAR +SE+D MTEYVVTRWYRAPELLLN +DY+AAID+ Sbjct: 162 RDLKPSNLLLNANCDLKIGDFGLARTTSETDFMTEYVVTRWYRAPELLLNCSDYTAAIDI 221 Query: 397 WSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFIR 531 WSVGCI E++ R PLFPGRD++HQ+RL+TE+IG+P D LGF+R Sbjct: 222 WSVGCILGEIVTRQPLFPGRDYVHQLRLVTELIGSPDDASLGFLR 266
>MPK4_ARATH (Q39024) Mitogen-activated protein kinase homolog 4 (EC 2.7.11.24)| (MAP kinase 4) (AtMPK4) Length = 376 Score = 263 bits (671), Expect = 3e-70 Identities = 121/169 (71%), Positives = 146/169 (86%) Frame = +1 Query: 25 ASEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA 204 A + +I P ++FNDVYI ELMDTDLH IIRSNQ L+++HC++FLYQLLRGLKY+HSA Sbjct: 104 AVKDIIKPPQRENFNDVYIVYELMDTDLHQIIRSNQPLTDDHCRFFLYQLLRGLKYVHSA 163 Query: 205 NVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSA 384 NV+HRDLKPSNLLLNANCDLK+ DFGLAR SE+D MTEYVVTRWYRAPELLLN ++Y+A Sbjct: 164 NVLHRDLKPSNLLLNANCDLKLGDFGLARTKSETDFMTEYVVTRWYRAPELLLNCSEYTA 223 Query: 385 AIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFIR 531 AID+WSVGCI E + R PLFPG+D++HQ+RLITE+IG+P D LGF+R Sbjct: 224 AIDIWSVGCILGETMTREPLFPGKDYVHQLRLITELIGSPDDSSLGFLR 272
>MPK5_ARATH (Q39025) Mitogen-activated protein kinase homolog 5 (EC 2.7.11.24)| (MAP kinase 5) (AtMPK5) Length = 376 Score = 258 bits (658), Expect = 9e-69 Identities = 119/165 (72%), Positives = 144/165 (87%) Frame = +1 Query: 37 VIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIH 216 +I P + F DVYI ELMDTDLH IIRSNQ L+++HCQYFLYQ+LRGLKYIHSANV+H Sbjct: 108 IIRPPKKEDFVDVYIVFELMDTDLHQIIRSNQSLNDDHCQYFLYQILRGLKYIHSANVLH 167 Query: 217 RDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDV 396 RDLKPSNLLLN+NCDLKI DFGLAR +SE++ MTEYVVTRWYRAPELLLNS++Y++AIDV Sbjct: 168 RDLKPSNLLLNSNCDLKITDFGLARTTSETEYMTEYVVTRWYRAPELLLNSSEYTSAIDV 227 Query: 397 WSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFIR 531 WSVGCIF E++ R PLFPG+D++HQ++LITE+IG+P L F+R Sbjct: 228 WSVGCIFAEIMTREPLFPGKDYVHQLKLITELIGSPDGASLEFLR 272
>NTF3_TOBAC (Q40517) Mitogen-activated protein kinase homolog NTF3 (EC| 2.7.11.24) (P43) Length = 372 Score = 232 bits (592), Expect = 4e-61 Identities = 109/169 (64%), Positives = 136/169 (80%), Gaps = 1/169 (0%) Frame = +1 Query: 25 ASEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA 204 A + V+ P +SF DVY+ ELMDTDLH II+S+Q LS +HCQYFL+QLLRGLKY+HSA Sbjct: 93 ALKDVMMPIHRRSFKDVYLVYELMDTDLHQIIKSSQTLSNDHCQYFLFQLLRGLKYLHSA 152 Query: 205 NVIHRDLKPSNLLLNANCDLKICDFGLARPSSESD-MMTEYVVTRWYRAPELLLNSTDYS 381 N++HRDLKP NLL+NANCDLKICDFGLAR SS D MTEYVVTRWYRAPELLL +Y Sbjct: 153 NILHRDLKPGNLLINANCDLKICDFGLARTSSGKDQFMTEYVVTRWYRAPELLLCCDNYG 212 Query: 382 AAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 +IDVWSVGCIF EL+ R P+FPG + ++Q++LI ++G+ ++D+ FI Sbjct: 213 TSIDVWSVGCIFAELLGRKPVFPGTECLNQLKLIINILGSQREEDIEFI 261
>MAPK_PETHY (Q40884) Mitogen-activated protein kinase homolog 1 (EC 2.7.11.24)| (PMEK1) Length = 384 Score = 230 bits (586), Expect = 2e-60 Identities = 107/169 (63%), Positives = 136/169 (80%), Gaps = 1/169 (0%) Frame = +1 Query: 25 ASEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA 204 A + V+ P +SF DVY+ ELMDTDLH II+S+Q LS +HCQYFL+QLLRGLKY+HSA Sbjct: 93 ALKDVMMPIQRRSFKDVYLVYELMDTDLHQIIKSSQTLSNDHCQYFLFQLLRGLKYLHSA 152 Query: 205 NVIHRDLKPSNLLLNANCDLKICDFGLARPSSESD-MMTEYVVTRWYRAPELLLNSTDYS 381 N++HRDLKP NLL+NANCDLKICDFGLAR SS D MTEYVVTRWYRAPELLL +Y Sbjct: 153 NILHRDLKPGNLLINANCDLKICDFGLARTSSGKDQFMTEYVVTRWYRAPELLLCCDNYG 212 Query: 382 AAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 +IDVWSVGCIF +++ R P+FPG + ++Q++LI ++G+ ++D+ FI Sbjct: 213 TSIDVWSVGCIFADVLGRKPVFPGTECLNQLKLIINILGSQREEDIEFI 261
>MPK7_ARATH (Q39027) Mitogen-activated protein kinase homolog 7 (EC 2.7.11.24)| (MAP kinase 7) (AtMPK7) Length = 368 Score = 229 bits (585), Expect = 3e-60 Identities = 107/169 (63%), Positives = 136/169 (80%), Gaps = 1/169 (0%) Frame = +1 Query: 25 ASEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA 204 A + V+ PA SF DVY+ ELMDTDLH II+S+Q LS++HC+YFL+QLLRGLKY+HSA Sbjct: 93 ALKDVMLPANRSSFKDVYLVYELMDTDLHQIIKSSQSLSDDHCKYFLFQLLRGLKYLHSA 152 Query: 205 NVIHRDLKPSNLLLNANCDLKICDFGLARPSSESD-MMTEYVVTRWYRAPELLLNSTDYS 381 N++HRDLKP NLL+NANCDLKICDFGLAR S ++ MTEYVVTRWYRAPELLL +Y Sbjct: 153 NILHRDLKPGNLLVNANCDLKICDFGLARTSQGNEQFMTEYVVTRWYRAPELLLCCDNYG 212 Query: 382 AAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 +IDVWSVGCIF E++ R P+FPG + ++Q++LI V+G+ + D+ FI Sbjct: 213 TSIDVWSVGCIFAEILGRKPIFPGTECLNQLKLIINVVGSQQESDIRFI 261
>MPK1_ARATH (Q39021) Mitogen-activated protein kinase homolog 1 (EC 2.7.11.24)| (MAP kinase 1) (AtMPK1) Length = 370 Score = 228 bits (582), Expect = 6e-60 Identities = 108/169 (63%), Positives = 134/169 (79%), Gaps = 1/169 (0%) Frame = +1 Query: 25 ASEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA 204 A + V+ P SF DVY+ ELMDTDLH II+S+Q LS +HCQYFL+QLLRGLKYIHSA Sbjct: 93 ALKDVMMPIHKMSFKDVYLVYELMDTDLHQIIKSSQVLSNDHCQYFLFQLLRGLKYIHSA 152 Query: 205 NVIHRDLKPSNLLLNANCDLKICDFGLARPS-SESDMMTEYVVTRWYRAPELLLNSTDYS 381 N++HRDLKP NLL+NANCDLKICDFGLAR S ++ MTEYVVTRWYRAPELLL +Y Sbjct: 153 NILHRDLKPGNLLVNANCDLKICDFGLARASNTKGQFMTEYVVTRWYRAPELLLCCDNYG 212 Query: 382 AAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 +IDVWSVGCIF EL+ R P+F G + ++Q++LI ++G+ ++DL FI Sbjct: 213 TSIDVWSVGCIFAELLGRKPIFQGTECLNQLKLIVNILGSQREEDLEFI 261
>MPK2_ARATH (Q39022) Mitogen-activated protein kinase homolog 2 (EC 2.7.11.24)| (MAP kinase 2) (AtMPK2) Length = 376 Score = 228 bits (581), Expect = 8e-60 Identities = 106/158 (67%), Positives = 131/158 (82%), Gaps = 1/158 (0%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 +SF DVY+ ELMDTDLH II+S+Q LS +HCQYFL+QLLRGLKYIHSAN++HRDLKP N Sbjct: 104 RSFKDVYLVYELMDTDLHQIIKSSQVLSNDHCQYFLFQLLRGLKYIHSANILHRDLKPGN 163 Query: 238 LLLNANCDLKICDFGLARPS-SESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCI 414 LL+NANCDLKICDFGLAR S ++ MTEYVVTRWYRAPELLL +Y +IDVWSVGCI Sbjct: 164 LLVNANCDLKICDFGLARTSNTKGQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCI 223 Query: 415 FMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 F EL+ R P+FPG + ++Q++LI ++G+ ++DL FI Sbjct: 224 FAELLGRKPVFPGTECLNQIKLIINILGSQREEDLEFI 261
>CPK1_CRYNE (Q8NK05) Mitogen-activated protein kinase CPK1 (EC 2.7.11.24)| (Stress-activated protein kinase CPK1) Length = 366 Score = 225 bits (573), Expect = 7e-59 Identities = 109/173 (63%), Positives = 134/173 (77%), Gaps = 9/173 (5%) Frame = +1 Query: 37 VIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIH 216 +I P + FN+VY+ ELM+TDLH +IRS QELS++HCQYF+YQ LRGLK +HSA+V+H Sbjct: 80 LIQPESYEVFNEVYLVQELMETDLHRVIRS-QELSDDHCQYFVYQTLRGLKALHSADVLH 138 Query: 217 RDLKPSNLLLNANCDLKICDFGLARPSSE---------SDMMTEYVVTRWYRAPELLLNS 369 RDLKPSNLLLNANCDLKICDFGLAR S++ MTEYV TRWYRAPE++L+ Sbjct: 139 RDLKPSNLLLNANCDLKICDFGLARSSAKPPPGTSDGGQGFMTEYVATRWYRAPEVMLSF 198 Query: 370 TDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 +Y+ AID+WSVGCI E+IN PLFPGRD+ HQ+ LI +V+GTPT DD I Sbjct: 199 QEYTKAIDLWSVGCILAEMINGKPLFPGRDYHHQLSLILQVLGTPTMDDFNEI 251
>ERK1_DICDI (P42525) Extracellular signal-regulated kinase 1 (EC 2.7.11.24)| (ERK1) (MAP kinase 1) Length = 415 Score = 221 bits (562), Expect = 1e-57 Identities = 101/163 (61%), Positives = 130/163 (79%), Gaps = 2/163 (1%) Frame = +1 Query: 37 VIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIH 216 ++ P + F DVYI +ELMDTDLH II S Q LS++HCQYF+YQ+LRGLK+IHSANV+H Sbjct: 96 ILKPNSKEQFEDVYIVSELMDTDLHQIITSPQPLSDDHCQYFVYQMLRGLKHIHSANVLH 155 Query: 217 RDLKPSNLLLNANCDLKICDFGLAR--PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAI 390 RDLKPSNLL+N +C LKICD GLAR ++ MTEYV TRWYRAPE++L+ Y+ AI Sbjct: 156 RDLKPSNLLINEDCLLKICDLGLARVEDATHQGFMTEYVATRWYRAPEVILSWNKYTKAI 215 Query: 391 DVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 D+WSVGCIF EL+ R PLF G+D++HQ+ LI E IG+P+++D+ Sbjct: 216 DIWSVGCIFAELLGRKPLFQGKDYIHQITLIIETIGSPSEEDI 258
>MAPK_FUSSO (Q00859) Mitogen-activated protein kinase (EC 2.7.11.24) (FsMAPK)| Length = 355 Score = 217 bits (552), Expect = 2e-56 Identities = 100/157 (63%), Positives = 128/157 (81%), Gaps = 4/157 (2%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 +SFN+VY+ ELM+TD+H IR+ Q+LS++HCQYF+YQ LR LK +HSANV+HRDLKPSN Sbjct: 94 ESFNEVYLIQELMETDMHRAIRT-QDLSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSN 152 Query: 238 LLLNANCDLKICDFGLARPSS----ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 LLLNANCDLK+CDFGLAR ++ S MTEYV TRWYRAPE++L +Y+ AIDVWSV Sbjct: 153 LLLNANCDLKVCDFGLARSAASQEDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSV 212 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 GCI E+++ PLFPG+D+ HQ+ LI +V+GTPT +D Sbjct: 213 GCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMED 249
>ERK1_CANAL (P28869) Extracellular signal-regulated kinase 1 (EC 2.7.11.24)| (ERK1) (MAP kinase 1) (MAPK 1) Length = 417 Score = 209 bits (533), Expect = 3e-54 Identities = 100/157 (63%), Positives = 127/157 (80%), Gaps = 4/157 (2%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 +SFN++Y+ ELM+TDLH +IR+ Q LS++H QYF+YQ LR LK +HSANV+HRDLKPSN Sbjct: 139 ESFNEIYLIQELMETDLHRVIRT-QNLSDDHIQYFIYQTLRALKAMHSANVLHRDLKPSN 197 Query: 238 LLLNANCDLKICDFGLARP-SSESD---MMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 LLLN+NCDLKICDFGLAR +S+ D MTEYV TRWYRAPE++L +Y+ AIDVWSV Sbjct: 198 LLLNSNCDLKICDFGLARSIASQEDNYGFMTEYVATRWYRAPEIMLTFQEYTTAIDVWSV 257 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 GCI E+++ PLFPGRD+ +Q+ LI EV+GTP +D Sbjct: 258 GCILAEMLSGRPLFPGRDYHNQLWLIMEVLGTPNMED 294
>SPK1_SCHPO (P27638) Mitogen-activated protein kinase spk1 (EC 2.7.11.24) (MAP| kinase spk1) (MAPK) Length = 372 Score = 209 bits (532), Expect = 4e-54 Identities = 99/169 (58%), Positives = 126/169 (74%), Gaps = 4/169 (2%) Frame = +1 Query: 37 VIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIH 216 ++PP Q DVYI ELM+TDL+ +IRS Q LS++HCQYF YQ+LR LK +HSA V+H Sbjct: 103 ILPPPSYQELEDVYIVQELMETDLYRVIRS-QPLSDDHCQYFTYQILRALKAMHSAGVVH 161 Query: 217 RDLKPSNLLLNANCDLKICDFGLARPSSESD----MMTEYVVTRWYRAPELLLNSTDYSA 384 RDLKPSNLLLNANCDLK+ DFGLAR ++ MTEYV TRWYRAPE++L+ +YS Sbjct: 162 RDLKPSNLLLNANCDLKVADFGLARSTTAQGGNPGFMTEYVATRWYRAPEIMLSFREYSK 221 Query: 385 AIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFIR 531 AID+WS GCI E+++ PLFPG+D+ Q+ LI ++GTPT DD I+ Sbjct: 222 AIDLWSTGCILAEMLSARPLFPGKDYHSQITLILNILGTPTMDDFSRIK 270
>MK07_MOUSE (Q9WVS8) Mitogen-activated protein kinase 7 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase) Length = 806 Score = 204 bits (518), Expect = 2e-52 Identities = 97/167 (58%), Positives = 128/167 (76%), Gaps = 6/167 (3%) Frame = +1 Query: 25 ASEXVIPPAIPQS-FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHS 201 A + ++ P +P F VY+ +LM++DLH II S+Q L+ EH +YFLYQLLRGLKY+HS Sbjct: 116 AIKDILKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHS 175 Query: 202 ANVIHRDLKPSNLLLNANCDLKICDFGLAR-----PSSESDMMTEYVVTRWYRAPELLLN 366 A VIHRDLKPSNLL+N NC+LKI DFG+AR P+ MTEYV TRWYRAPEL+L+ Sbjct: 176 AQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLS 235 Query: 367 STDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPT 507 +Y+ AID+WSVGCIF E++ R LFPG++++HQ++LI V+GTP+ Sbjct: 236 LHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPS 282
>FUS3_YEAST (P16892) Mitogen-activated protein kinase FUS3 (EC 2.7.11.24) (MAP| kinase FUS3) Length = 353 Score = 204 bits (518), Expect = 2e-52 Identities = 99/166 (59%), Positives = 123/166 (74%), Gaps = 12/166 (7%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 ++FN+VYI ELM TDLH +I S Q LS++H QYF+YQ LR +K +H +NVIHRDLKPSN Sbjct: 84 ENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSN 142 Query: 238 LLLNANCDLKICDFGLAR-----------PSSESDMMTEYVVTRWYRAPELLLNSTDYSA 384 LL+N+NCDLK+CDFGLAR P+ + MTEYV TRWYRAPE++L S YS Sbjct: 143 LLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSR 202 Query: 385 AIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP-TDDDL 519 A+DVWS GCI EL R P+FPGRD+ HQ+ LI +IGTP +D+DL Sbjct: 203 AMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248
>MK07_HUMAN (Q13164) Mitogen-activated protein kinase 7 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase) Length = 815 Score = 203 bits (517), Expect = 2e-52 Identities = 97/167 (58%), Positives = 128/167 (76%), Gaps = 6/167 (3%) Frame = +1 Query: 25 ASEXVIPPAIPQS-FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHS 201 A + ++ P +P F VY+ +LM++DLH II S+Q L+ EH +YFLYQLLRGLKY+HS Sbjct: 115 AIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHS 174 Query: 202 ANVIHRDLKPSNLLLNANCDLKICDFGLAR-----PSSESDMMTEYVVTRWYRAPELLLN 366 A VIHRDLKPSNLL+N NC+LKI DFG+AR P+ MTEYV TRWYRAPEL+L+ Sbjct: 175 AQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLS 234 Query: 367 STDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPT 507 +Y+ AID+WSVGCIF E++ R LFPG++++HQ++LI V+GTP+ Sbjct: 235 LHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPS 281
>SPM1_SCHPO (Q92398) Mitogen-activated protein kinase spm1 (EC 2.7.11.24) (MAP| kinase spm1) (MAP kinase pmk1) Length = 422 Score = 201 bits (512), Expect = 8e-52 Identities = 97/163 (59%), Positives = 121/163 (74%), Gaps = 5/163 (3%) Frame = +1 Query: 55 PQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPS 234 P +FN+VYI ELM+ DL+ II+S Q L++ H Q F+YQ+L GLKYIHSANVIHRDLKP Sbjct: 94 PYNFNEVYIYEELMEADLNAIIKSGQPLTDAHFQSFIYQILCGLKYIHSANVIHRDLKPG 153 Query: 235 NLLLNANCDLKICDFGLARPSSES-----DMMTEYVVTRWYRAPELLLNSTDYSAAIDVW 399 NLL+NA+C+LKICDFGLAR SE+ MTEYV TRWYRAPE++L+ + Y IDVW Sbjct: 154 NLLVNADCELKICDFGLARGCSENPEENPGFMTEYVATRWYRAPEIMLSFSSYHKGIDVW 213 Query: 400 SVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 SVGCI EL+ PLF G+D +HQ+ LI +GTP ++ L I Sbjct: 214 SVGCILAELLGGTPLFKGKDFVHQLNLILHQLGTPDEETLSHI 256
>SUR1_CAEEL (P39745) Mitogen-activated protein kinase mpk-1 (EC 2.7.11.24) (MAP| kinase sur-1) Length = 444 Score = 199 bits (506), Expect = 4e-51 Identities = 94/167 (56%), Positives = 125/167 (74%), Gaps = 4/167 (2%) Frame = +1 Query: 31 EXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANV 210 + +I S D+YI LM+TDL+ ++++ Q+LS +H YFLYQ+LRGLKYIHSANV Sbjct: 158 QEIIRSETVDSLKDIYIVQCLMETDLYKLLKT-QKLSNDHVCYFLYQILRGLKYIHSANV 216 Query: 211 IHRDLKPSNLLLNANCDLKICDFGLAR----PSSESDMMTEYVVTRWYRAPELLLNSTDY 378 +HRDLKPSNLLLN CDLKICDFGLAR + + +TEYV TRWYRAPE++LNS Y Sbjct: 217 LHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGY 276 Query: 379 SAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 + +IDVWSVGCI E+++ PLFPG+ ++ Q+ LI V+G+P++ DL Sbjct: 277 TKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADL 323
>MKC1_CANAL (P43068) Mitogen-activated protein kinase MKC1 (EC 2.7.11.24) (MAP| kinase MKC1) Length = 501 Score = 198 bits (504), Expect = 7e-51 Identities = 91/166 (54%), Positives = 123/166 (74%), Gaps = 5/166 (3%) Frame = +1 Query: 37 VIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIH 216 +IP + FN++Y+ ELM+ D+H IIRS Q LS++H Q F+YQ+L GL +IHSA+V+H Sbjct: 113 IIPNPMTGEFNEIYLYEELMECDMHQIIRSGQPLSDQHYQSFIYQVLCGLNFIHSADVLH 172 Query: 217 RDLKPSNLLLNANCDLKICDFGLAR-----PSSESDMMTEYVVTRWYRAPELLLNSTDYS 381 RDLKP NLL+NA+C+LKICDFGLAR P + MTEYV TRWYRAPE++L+ T+Y+ Sbjct: 173 RDLKPGNLLVNADCELKICDFGLARGFSENPDENAGFMTEYVATRWYRAPEIMLSFTNYT 232 Query: 382 AAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 AID+WSVGCI EL+ PLF G+D++ Q+ I ++GTP + L Sbjct: 233 KAIDIWSVGCILAELLGGKPLFRGKDYVDQLNQILMILGTPPESTL 278
>MK03_HUMAN (P27361) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) Length = 379 Score = 198 bits (503), Expect = 9e-51 Identities = 90/161 (55%), Positives = 123/161 (76%), Gaps = 4/161 (2%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 ++ DVYI +LM+TDL+ +++S Q+LS +H YFLYQ+LRGLKYIHSANV+HRDLKPSN Sbjct: 113 EAMRDVYIVQDLMETDLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSN 171 Query: 238 LLLNANCDLKICDFGLAR----PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 LL+N CDLKICDFGLAR + +TEYV TRWYRAPE++LNS Y+ +ID+WSV Sbjct: 172 LLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSV 231 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 GCI E+++ P+FPG+ ++ Q+ I ++G+P+ +DL I Sbjct: 232 GCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272
>MK03_RAT (P21708) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) (MNK1) Length = 380 Score = 198 bits (503), Expect = 9e-51 Identities = 90/161 (55%), Positives = 123/161 (76%), Gaps = 4/161 (2%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 ++ DVYI +LM+TDL+ +++S Q+LS +H YFLYQ+LRGLKYIHSANV+HRDLKPSN Sbjct: 114 EAMRDVYIVQDLMETDLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSN 172 Query: 238 LLLNANCDLKICDFGLAR----PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 LL+N CDLKICDFGLAR + +TEYV TRWYRAPE++LNS Y+ +ID+WSV Sbjct: 173 LLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSV 232 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 GCI E+++ P+FPG+ ++ Q+ I ++G+P+ +DL I Sbjct: 233 GCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 273
>MK03_MOUSE (Q63844) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) (MNK1) Length = 380 Score = 198 bits (503), Expect = 9e-51 Identities = 90/161 (55%), Positives = 123/161 (76%), Gaps = 4/161 (2%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 ++ DVYI +LM+TDL+ +++S Q+LS +H YFLYQ+LRGLKYIHSANV+HRDLKPSN Sbjct: 114 EAMRDVYIVQDLMETDLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSN 172 Query: 238 LLLNANCDLKICDFGLAR----PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 LL+N CDLKICDFGLAR + +TEYV TRWYRAPE++LNS Y+ +ID+WSV Sbjct: 173 LLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSV 232 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 GCI E+++ P+FPG+ ++ Q+ I ++G+P+ +DL I Sbjct: 233 GCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 273
>MK01_RAT (P63086) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 197 bits (502), Expect = 1e-50 Identities = 93/171 (54%), Positives = 127/171 (74%), Gaps = 4/171 (2%) Frame = +1 Query: 28 SEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSAN 207 ++ + P I Q DVYI +LM+TDL+ ++++ Q LS +H YFLYQ+LRGLKYIHSAN Sbjct: 84 NDIIRAPTIEQ-MKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSAN 141 Query: 208 VIHRDLKPSNLLLNANCDLKICDFGLARPS----SESDMMTEYVVTRWYRAPELLLNSTD 375 V+HRDLKPSNLLLN CDLKICDFGLAR + + +TEYV TRWYRAPE++LNS Sbjct: 142 VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKG 201 Query: 376 YSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 Y+ +ID+WSVGCI E+++ P+FPG+ ++ Q+ I ++G+P+ +DL I Sbjct: 202 YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 252
>MK01_MOUSE (P63085) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 197 bits (502), Expect = 1e-50 Identities = 93/171 (54%), Positives = 127/171 (74%), Gaps = 4/171 (2%) Frame = +1 Query: 28 SEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSAN 207 ++ + P I Q DVYI +LM+TDL+ ++++ Q LS +H YFLYQ+LRGLKYIHSAN Sbjct: 84 NDIIRAPTIEQ-MKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSAN 141 Query: 208 VIHRDLKPSNLLLNANCDLKICDFGLARPS----SESDMMTEYVVTRWYRAPELLLNSTD 375 V+HRDLKPSNLLLN CDLKICDFGLAR + + +TEYV TRWYRAPE++LNS Sbjct: 142 VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKG 201 Query: 376 YSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 Y+ +ID+WSVGCI E+++ P+FPG+ ++ Q+ I ++G+P+ +DL I Sbjct: 202 YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 252
>MK01_HUMAN (P28482) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 197 bits (502), Expect = 1e-50 Identities = 93/171 (54%), Positives = 127/171 (74%), Gaps = 4/171 (2%) Frame = +1 Query: 28 SEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSAN 207 ++ + P I Q DVYI +LM+TDL+ ++++ Q LS +H YFLYQ+LRGLKYIHSAN Sbjct: 86 NDIIRAPTIEQ-MKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSAN 143 Query: 208 VIHRDLKPSNLLLNANCDLKICDFGLARPS----SESDMMTEYVVTRWYRAPELLLNSTD 375 V+HRDLKPSNLLLN CDLKICDFGLAR + + +TEYV TRWYRAPE++LNS Sbjct: 144 VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKG 203 Query: 376 YSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 Y+ +ID+WSVGCI E+++ P+FPG+ ++ Q+ I ++G+P+ +DL I Sbjct: 204 YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 254
>MK01_BOVIN (P46196) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 197 bits (502), Expect = 1e-50 Identities = 93/171 (54%), Positives = 127/171 (74%), Gaps = 4/171 (2%) Frame = +1 Query: 28 SEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSAN 207 ++ + P I Q DVYI +LM+TDL+ ++++ Q LS +H YFLYQ+LRGLKYIHSAN Sbjct: 86 NDIIRAPTIEQ-MKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSAN 143 Query: 208 VIHRDLKPSNLLLNANCDLKICDFGLARPS----SESDMMTEYVVTRWYRAPELLLNSTD 375 V+HRDLKPSNLLLN CDLKICDFGLAR + + +TEYV TRWYRAPE++LNS Sbjct: 144 VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKG 203 Query: 376 YSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 Y+ +ID+WSVGCI E+++ P+FPG+ ++ Q+ I ++G+P+ +DL I Sbjct: 204 YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 254
>MK01_XENLA (P26696) Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Myelin| xP42 protein kinase) (Myelin basic protein kinase) (MBP kinase) (M phase MAP kinase) Length = 361 Score = 197 bits (502), Expect = 1e-50 Identities = 93/171 (54%), Positives = 127/171 (74%), Gaps = 4/171 (2%) Frame = +1 Query: 28 SEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSAN 207 ++ + P I Q DVYI +LM+TDL+ ++++ Q LS +H YFLYQ+LRGLKYIHSAN Sbjct: 90 NDIIRAPTIEQ-MKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSAN 147 Query: 208 VIHRDLKPSNLLLNANCDLKICDFGLARPS----SESDMMTEYVVTRWYRAPELLLNSTD 375 V+HRDLKPSNLLLN CDLKICDFGLAR + + +TEYV TRWYRAPE++LNS Sbjct: 148 VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKG 207 Query: 376 YSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 Y+ +ID+WSVGCI E+++ P+FPG+ ++ Q+ I ++G+P+ +DL I Sbjct: 208 YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 258
>KSS1_YEAST (P14681) Mitogen-activated protein kinase KSS1 (EC 2.7.11.24) (MAP| kinase KSS1) (Kinase suppressor of SST2) Length = 368 Score = 195 bits (495), Expect = 7e-50 Identities = 96/176 (54%), Positives = 123/176 (69%), Gaps = 12/176 (6%) Frame = +1 Query: 40 IPPAIPQSFNDVYIATELMDTDLHHIIRSNQE----LSEEHCQYFLYQLLRGLKYIHSAN 207 + P N VY+ ELM+TDL +I + LS++H QYF YQ+LR LK IHSA Sbjct: 79 VRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQ 138 Query: 208 VIHRDLKPSNLLLNANCDLKICDFGLARP-SSESD-------MMTEYVVTRWYRAPELLL 363 VIHRD+KPSNLLLN+NCDLK+CDFGLAR +S SD MTEYV TRWYRAPE++L Sbjct: 139 VIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIML 198 Query: 364 NSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFIR 531 +Y+ A+D+WS GCI E+++ PLFPGRD+ HQ+ LI EV+GTP+ +D I+ Sbjct: 199 TFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSFEDFNQIK 254
>MK14A_DROME (O62618) Mitogen-activated protein kinase 14A (EC 2.7.11.24) (MAP| kinase p38a) (p38 MAPK) (Dp38) (D-p38a) Length = 366 Score = 194 bits (492), Expect = 2e-49 Identities = 90/149 (60%), Positives = 114/149 (76%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 ++F VY+ T LMD DL++IIR Q LS++H Q+ +YQ+LRGLKYIHSA VIHRDLKPSN Sbjct: 101 ENFQQVYLVTHLMDADLNNIIRM-QHLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSN 159 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 + +N +C+L+I DFGLARP+ MT YV TRWYRAPE++LN Y +D+WSVGCI Sbjct: 160 IAVNEDCELRILDFGLARPTENE--MTGYVATRWYRAPEIMLNWMHYDQTVDIWSVGCIM 217 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTP 504 ELI R LFPG DH+HQ+ LI E++GTP Sbjct: 218 AELITRRTLFPGTDHIHQLNLIMEMLGTP 246
>ERKA_DROME (P40417) Mitogen-activated protein kinase ERK-A (EC 2.7.11.24)| (Extracellular-regulated kinase A) (Protein rolled) Length = 376 Score = 193 bits (491), Expect = 2e-49 Identities = 91/154 (59%), Positives = 118/154 (76%), Gaps = 4/154 (2%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 DVYI LM+TDL+ ++++ Q LS +H YFLYQ+LRGLKYIHSANV+HRDLKPSNLLLN Sbjct: 113 DVYIVQCLMETDLYKLLKT-QRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 171 Query: 250 ANCDLKICDFGLAR----PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 CDLKICDFGLAR + +TEYV TRWYRAPE++LNS Y+ +ID+WSVGCI Sbjct: 172 KTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL 231 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 E+++ P+FPG+ ++ Q+ I V+G+P+ DDL Sbjct: 232 AEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDL 265
>MK14B_DROME (O61443) Mitogen-activated protein kinase 14B (EC 2.7.11.24) (MAP| kinase p38b) (D-p38b) Length = 365 Score = 193 bits (490), Expect = 3e-49 Identities = 90/150 (60%), Positives = 115/150 (76%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 F VY+ T LMD DL++IIR+ Q+LS++H Q+ +YQ+LRGLKYIHSA VIHRDLKPSN+ Sbjct: 102 FQQVYMVTHLMDADLNNIIRT-QKLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIA 160 Query: 244 LNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 +N +C+L+I DFGLARP+ MT YV TRWYRAPE++LN Y+ D+WSVGCI E Sbjct: 161 VNEDCELRILDFGLARPAESE--MTGYVATRWYRAPEIMLNWMHYNQTADIWSVGCIMAE 218 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 L+ LFPG DH+HQ+ LI EV+GTP D+ Sbjct: 219 LLTGRTLFPGTDHIHQLNLIMEVLGTPADE 248
>STY1_SCHPO (Q09892) Mitogen-activated protein kinase sty1 (EC 2.7.11.24) (MAP| kinase sty1) (MAP kinase spc1) Length = 349 Score = 191 bits (484), Expect = 1e-48 Identities = 88/147 (59%), Positives = 112/147 (76%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 F D+Y TEL+ TDLH ++ S + L + QYFLYQ+LRGLK++HSA VIHRDLKPSN+L Sbjct: 90 FEDIYFVTELLGTDLHRLLTS-RPLETQFIQYFLYQILRGLKFVHSAGVIHRDLKPSNIL 148 Query: 244 LNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 +N NCDLKICDFGLAR + MT YV TR+YRAPE++L Y+ +D+WS GCIF E Sbjct: 149 INENCDLKICDFGLAR--IQDPQMTGYVSTRYYRAPEIMLTWQKYNVEVDIWSAGCIFAE 206 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTP 504 +I PLFPGRDH++Q +ITE++GTP Sbjct: 207 MIEGKPLFPGRDHVNQFSIITELLGTP 233
>HOG1_ASHGO (Q750A9) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 190 bits (482), Expect = 2e-48 Identities = 86/148 (58%), Positives = 113/148 (76%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 D+Y TEL TDLH ++++ + L ++ QYFLYQ+LRGLKY+HSA VIHRDLKPSN+L+N Sbjct: 95 DIYFVTELQGTDLHRLLQT-RPLEKQFLQYFLYQILRGLKYVHSAGVIHRDLKPSNILIN 153 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 NCDLKICDFGLAR + MT YV TR+YRAPE++L Y+ +D+WS GCIF E+I Sbjct: 154 ENCDLKICDFGLAR--IQDPQMTGYVSTRYYRAPEIMLTWQKYNVEVDIWSAGCIFAEMI 211 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDD 513 PLFPG+DH+HQ +IT+++G+P D Sbjct: 212 EGKPLFPGKDHVHQFSIITDLLGSPPKD 239
>HOG1_YEAST (P32485) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) (Osmosensing protein HOG1) Length = 435 Score = 190 bits (482), Expect = 2e-48 Identities = 87/153 (56%), Positives = 114/153 (74%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 D+Y TEL TDLH ++++ + L ++ QYFLYQ+LRGLKY+HSA VIHRDLKPSN+L+N Sbjct: 95 DIYFVTELQGTDLHRLLQT-RPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILIN 153 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 NCDLKICDFGLAR + MT YV TR+YRAPE++L Y +D+WS GCIF E+I Sbjct: 154 ENCDLKICDFGLAR--IQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMI 211 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 PLFPG+DH+HQ +IT+++G+P D + I Sbjct: 212 EGKPLFPGKDHVHQFSIITDLLGSPPKDVINTI 244
>HOG1_ZYGRO (O93982) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 380 Score = 189 bits (481), Expect = 3e-48 Identities = 87/153 (56%), Positives = 114/153 (74%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 D+Y TEL TDLH ++++ + L ++ QYFLYQ+LRGLKY+HSA VIHRDLKPSN+L+N Sbjct: 95 DIYFVTELQGTDLHRLLQT-RPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILIN 153 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 NCDLKICDFGLAR + MT YV TR+YRAPE++L Y +D+WS GCIF E+I Sbjct: 154 ENCDLKICDFGLAR--IQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFSEMI 211 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 PLFPG+DH+HQ +IT+++G+P D + I Sbjct: 212 EGKPLFPGKDHVHQFSIITDLLGSPPRDVINTI 244
>SLT2_YEAST (Q00772) Mitogen-activated protein kinase SLT2/MPK1 (EC 2.7.11.24)| (MAP kinase MPK1) Length = 484 Score = 189 bits (480), Expect = 4e-48 Identities = 88/158 (55%), Positives = 115/158 (72%), Gaps = 5/158 (3%) Frame = +1 Query: 61 SFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNL 240 S N +Y+ ELM+ D+H II+S Q L++ H Q F YQ+L GLKYIHSA+V+HRDLKP NL Sbjct: 100 SINGLYLYEELMECDMHQIIKSGQPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNL 159 Query: 241 LLNANCDLKICDFGLAR-----PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 L+NA+C LKICDFGLAR P S +TEYV TRWYRAPE++L+ Y+ AIDVWS Sbjct: 160 LVNADCQLKICDFGLARGYSENPVENSQFLTEYVATRWYRAPEIMLSYQGYTKAIDVWSA 219 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 GCI E + P+F G+D+++Q+ I +V+GTP D+ L Sbjct: 220 GCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDETL 257
>HOG1_DEBHA (Q9UV50) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 387 Score = 187 bits (476), Expect = 1e-47 Identities = 87/148 (58%), Positives = 110/148 (74%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 D+Y TEL TDLH ++ S + L ++ QYF YQ+LRGLKY+HSA VIHRDLKPSN+L+N Sbjct: 95 DIYFVTELQGTDLHRLLTS-RPLEKQFIQYFTYQILRGLKYVHSAGVIHRDLKPSNILIN 153 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 NCDLKICDFGLAR + MT YV TR+YRAPE++L Y +D+WSVGCI E+I Sbjct: 154 ENCDLKICDFGLAR--IQDPQMTGYVSTRYYRAPEIMLTWQKYDTEVDLWSVGCILSEMI 211 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDD 513 PLFPG+DH+HQ +ITE++G+P D Sbjct: 212 EGKPLFPGKDHVHQFSIITELLGSPPPD 239
>HOG1_CANGA (Q6FIU2) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 187 bits (474), Expect = 2e-47 Identities = 84/148 (56%), Positives = 111/148 (75%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 D+Y TEL TDLH ++++ + L ++ QYF YQ+LRGLKY+HSA V+HRDLKPSN+L+N Sbjct: 95 DIYFVTELQGTDLHRLLQT-RPLEKQFVQYFHYQILRGLKYVHSAGVVHRDLKPSNILIN 153 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 NCDLKICDFGLAR + MT YV TR+YRAPE++L Y +D+WS GCIF E+I Sbjct: 154 ENCDLKICDFGLAR--IQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMI 211 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDD 513 PLFPG+DH+HQ +IT+++G+P D Sbjct: 212 EGKPLFPGKDHVHQFSIITDLLGSPPSD 239
>MK14_CANFA (O02812) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) Length = 359 Score = 187 bits (474), Expect = 2e-47 Identities = 86/152 (56%), Positives = 116/152 (76%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + FNDVY+ T LM DL++I++ Q+L+++H Q+ +YQ+LRGLKYIHSA++IHRDLKPSN Sbjct: 96 EEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSN 154 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L +N +C+LKI DFGLAR + D MT YV TRWYRAPE++LN Y+ +D+WSVGCI Sbjct: 155 LAVNEDCELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 212 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 EL+ LFPG DH+ Q++LI ++GTP D Sbjct: 213 AELLTGRTLFPGTDHIDQLKLILRLVGTPGAD 244
>NLK_MOUSE (O54949) Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like| kinase) Length = 515 Score = 186 bits (473), Expect = 3e-47 Identities = 92/163 (56%), Positives = 121/163 (74%), Gaps = 2/163 (1%) Frame = +1 Query: 25 ASEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA 204 A + + PP I F ++Y+ TELM +DLH II S Q LS +H + FLYQ+LRGLKY+HSA Sbjct: 188 ALDILQPPHIDY-FEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSA 246 Query: 205 NVIHRDLKPSNLLLNANCDLKICDFGLARPS--SESDMMTEYVVTRWYRAPELLLNSTDY 378 ++HRD+KP NLL+N+NC LKICDFGLAR ES MT+ VVT++YRAPE+L+ S Y Sbjct: 247 GILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHY 306 Query: 379 SAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPT 507 S AID+WSVGCIF EL+ R LF + + Q+ LIT+++GTP+ Sbjct: 307 SNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPS 349
>NLK_HUMAN (Q9UBE8) Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like| kinase) (LAK1 protein) Length = 515 Score = 186 bits (473), Expect = 3e-47 Identities = 92/163 (56%), Positives = 121/163 (74%), Gaps = 2/163 (1%) Frame = +1 Query: 25 ASEXVIPPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA 204 A + + PP I F ++Y+ TELM +DLH II S Q LS +H + FLYQ+LRGLKY+HSA Sbjct: 188 ALDILQPPHIDY-FEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSA 246 Query: 205 NVIHRDLKPSNLLLNANCDLKICDFGLARPS--SESDMMTEYVVTRWYRAPELLLNSTDY 378 ++HRD+KP NLL+N+NC LKICDFGLAR ES MT+ VVT++YRAPE+L+ S Y Sbjct: 247 GILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHY 306 Query: 379 SAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPT 507 S AID+WSVGCIF EL+ R LF + + Q+ LIT+++GTP+ Sbjct: 307 SNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPS 349
>MK14_RAT (P70618) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1) Length = 359 Score = 186 bits (472), Expect = 3e-47 Identities = 85/149 (57%), Positives = 115/149 (77%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + FNDVY+ T LM DL++I++ Q+L+++H Q+ +YQ+LRGLKYIHSA++IHRDLKPSN Sbjct: 96 EEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSN 154 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L +N +C+LKI DFGLAR + D MT YV TRWYRAPE++LN Y+ +D+WSVGCI Sbjct: 155 LAVNEDCELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 212 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTP 504 EL+ LFPG DH+ Q++LI ++GTP Sbjct: 213 AELLTGRTLFPGTDHIDQLKLILRLVGTP 241
>MK14_MOUSE (P47811) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1) Length = 359 Score = 186 bits (472), Expect = 3e-47 Identities = 85/149 (57%), Positives = 115/149 (77%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + FNDVY+ T LM DL++I++ Q+L+++H Q+ +YQ+LRGLKYIHSA++IHRDLKPSN Sbjct: 96 EEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSN 154 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L +N +C+LKI DFGLAR + D MT YV TRWYRAPE++LN Y+ +D+WSVGCI Sbjct: 155 LAVNEDCELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 212 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTP 504 EL+ LFPG DH+ Q++LI ++GTP Sbjct: 213 AELLTGRTLFPGTDHIDQLKLILRLVGTP 241
>MK14_HUMAN (Q16539) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting prote Length = 359 Score = 186 bits (472), Expect = 3e-47 Identities = 85/149 (57%), Positives = 115/149 (77%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + FNDVY+ T LM DL++I++ Q+L+++H Q+ +YQ+LRGLKYIHSA++IHRDLKPSN Sbjct: 96 EEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSN 154 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L +N +C+LKI DFGLAR + D MT YV TRWYRAPE++LN Y+ +D+WSVGCI Sbjct: 155 LAVNEDCELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 212 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTP 504 EL+ LFPG DH+ Q++LI ++GTP Sbjct: 213 AELLTGRTLFPGTDHIDQLKLILRLVGTP 241
>MK14_XENLA (P47812) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated Mitogen-activated protein kinase 2) (MAP kinase 2) (MPK2) Length = 361 Score = 186 bits (472), Expect = 3e-47 Identities = 85/149 (57%), Positives = 114/149 (76%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + FNDVY+ T LM DL++I++ Q+L+++H Q+ +YQ+LRGLKYIHSA +IHRDLKPSN Sbjct: 98 EEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSAGIIHRDLKPSN 156 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L +N +C+LKI DFGLAR + E MT YV TRWYRAPE++LN Y+ +D+WSVGCI Sbjct: 157 LAVNEDCELKILDFGLARHTDEE--MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 214 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTP 504 EL+ LFPG DH+ Q++LI ++GTP Sbjct: 215 AELLTGRTLFPGTDHIDQLKLILRLVGTP 243
>HOG1_CANAL (Q92207) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 377 Score = 185 bits (470), Expect = 6e-47 Identities = 86/148 (58%), Positives = 109/148 (73%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 D+Y EL TDLH ++ S + L ++ QYF YQ++RGLKYIHSA VIHRDLKPSN+L+N Sbjct: 95 DIYFVNELQGTDLHRLLNS-RPLEKQFIQYFTYQIMRGLKYIHSAGVIHRDLKPSNILIN 153 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 NCDLKICDFGLAR + MT YV TR+YRAPE++L Y +D+WSVGCI E+I Sbjct: 154 ENCDLKICDFGLAR--LQDPQMTGYVSTRYYRAPEIMLTWQKYDTEVDLWSVGCILAEMI 211 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDD 513 PLFPG+DH+HQ +ITE++G+P D Sbjct: 212 EGKPLFPGKDHVHQFSIITELLGSPPAD 239
>MK14A_CYPCA (Q90336) Mitogen-activated protein kinase 14a (EC 2.7.11.24)| (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (cp38a) Length = 361 Score = 183 bits (464), Expect = 3e-46 Identities = 85/154 (55%), Positives = 115/154 (74%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + FNDVY+ T LM DL++I++ Q+L+++H Q+ +YQ+LRGLKYIHSA++IHRD Sbjct: 93 PATSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSADIIHRD 151 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSNL +N +C+LKI DFGLAR + D MT YV TRWYRAPE++LN Y+ +D+WS Sbjct: 152 LKPSNLAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWS 209 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI EL+ LFPG DH++Q++ I + GTP Sbjct: 210 VGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP 243
>MK14A_BRARE (Q9DGE2) Mitogen-activated protein kinase 14a (EC 2.7.11.24)| (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (zp38a) Length = 361 Score = 183 bits (464), Expect = 3e-46 Identities = 85/154 (55%), Positives = 115/154 (74%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + FNDVY+ T LM DL++I++ Q+L+++H Q+ +YQ+LRGLKYIHSA++IHRD Sbjct: 93 PATSLKEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSADIIHRD 151 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSNL +N +C+LKI DFGLAR + D MT YV TRWYRAPE++LN Y+ +D+WS Sbjct: 152 LKPSNLAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLNWMHYNVTVDIWS 209 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI EL+ LFPG DH++Q++ I + GTP Sbjct: 210 VGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP 243
>MK14_PANTR (Q95NE7) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) Length = 359 Score = 182 bits (463), Expect = 4e-46 Identities = 84/149 (56%), Positives = 114/149 (76%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + FNDVY+ T LM DL++I++ Q+L+++H Q+ +YQ+LRGLKYIHSA++IHRDLKPSN Sbjct: 96 EEFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSN 154 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L +N +C+LKI DFGLAR + D MT YV TRWYRAPE++LN Y+ +D+WSVGCI Sbjct: 155 LAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIM 212 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTP 504 EL+ LFPG DH++Q++ I + GTP Sbjct: 213 AELLTGRTLFPGTDHINQLQQIMRLTGTP 241
>MK14B_CYPCA (Q9I958) Mitogen-activated protein kinase 14b (EC 2.7.11.24)| (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (cp38b) Length = 361 Score = 182 bits (461), Expect = 7e-46 Identities = 85/154 (55%), Positives = 114/154 (74%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P FNDVY+ T LM DL++I++ Q+L+++H Q+ +YQ+LRGLKYIHSA++IHRD Sbjct: 93 PATCLAGFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSADIIHRD 151 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSNL +N +C+LKI DFGLAR + D MT YV TRWYRAPE++LN Y+ +D+WS Sbjct: 152 LKPSNLAVNEDCELKILDFGLARLT--DDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWS 209 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI EL+ LFPG DH++Q++ I + GTP Sbjct: 210 VGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP 243
>MK11_MOUSE (Q9WUI1) Mitogen-activated protein kinase 11 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B) Length = 364 Score = 180 bits (457), Expect = 2e-45 Identities = 86/162 (53%), Positives = 117/162 (72%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + F++VY+ T LM DL++I++ Q LS+EH Q+ +YQLLRGLKYIHSA +IHRD Sbjct: 92 PATSIEDFSEVYLVTTLMGADLNNIVKC-QALSDEHVQFLVYQLLRGLKYIHSAGIIHRD 150 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSN+ +N +C+L+I DFGLA + E MT YV TRWYRAPE++LN Y+ +D+WS Sbjct: 151 LKPSNVAVNEDCELRILDFGLAPQADEE--MTGYVATRWYRAPEIMLNWMHYNQTVDIWS 208 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 VGCI EL+ LFPG D++ Q++ I EV+GTP+ + L I Sbjct: 209 VGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKI 250
>MK14B_BRARE (Q9DGE1) Mitogen-activated protein kinase 14b (EC 2.7.11.24)| (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (zp38b) Length = 348 Score = 180 bits (457), Expect = 2e-45 Identities = 84/154 (54%), Positives = 114/154 (74%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + FNDVY+ T LM DL++I++ Q+L+++H Q+ +YQ+LR LKYIHSA++IHRD Sbjct: 93 PATSLEGFNDVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRALKYIHSADIIHRD 151 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSNL +N +C+LKI DFGLAR + D MT YV TRWYRAPE++LN Y+ +D+WS Sbjct: 152 LKPSNLAVNEDCELKILDFGLARLTD--DEMTGYVATRWYRAPEIMLNWMHYNMTVDIWS 209 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI EL+ LFPG DH++Q++ I + GTP Sbjct: 210 VGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTP 243
>MK11_HUMAN (Q15759) Mitogen-activated protein kinase 11 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress-activated protein kinase 2) Length = 372 Score = 174 bits (440), Expect = 2e-43 Identities = 84/169 (49%), Positives = 115/169 (68%), Gaps = 7/169 (4%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSE-------EHCQYFLYQLLRGLKYIHS 201 P + F++VY+ T LM DL++I++ + EH Q+ +YQLLRGLKYIHS Sbjct: 92 PATSIEDFSEVYLVTTLMGADLNNIVKCQAGAHQGARLALDEHVQFLVYQLLRGLKYIHS 151 Query: 202 ANVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYS 381 A +IHRDLKPSN+ +N +C+L+I DFGLAR + E MT YV TRWYRAPE++LN Y+ Sbjct: 152 AGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVATRWYRAPEIMLNWMHYN 209 Query: 382 AAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 +D+WSVGCI EL+ LFPG D++ Q++ I EV+GTP+ + L I Sbjct: 210 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 258
>PMK1_CAEEL (Q17446) Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (p38| MAP kinase 1) (Stress-activated protein kinase pmk-1) Length = 377 Score = 172 bits (436), Expect = 5e-43 Identities = 83/150 (55%), Positives = 108/150 (72%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 DVY + LM DL +I++ Q L+++H Q+ +YQ+LRGLKYIHSA++IHRDLKPSN+ +N Sbjct: 112 DVYFVSMLMGADLSNILKI-QRLNDDHIQFLVYQILRGLKYIHSADIIHRDLKPSNIAVN 170 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 +C+LKI DFGLAR + MT YV TRWYRAPE++LN Y+ +DVWSVGCI ELI Sbjct: 171 EDCELKILDFGLARQTDSE--MTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELI 228 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 LFPG DH+ Q+ I V GTP ++ L Sbjct: 229 TGKTLFPGSDHIDQLTRIMSVTGTPDEEFL 258
>SMK1_YEAST (P41808) Sporulation-specific mitogen-activated protein kinase SMK1| (EC 2.7.11.24) (MAP kinase SMK1) Length = 388 Score = 171 bits (432), Expect = 2e-42 Identities = 87/161 (54%), Positives = 110/161 (68%), Gaps = 9/161 (5%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 ++ +Y EL+D DL +I S+ +LSE H +YFLYQ+L GLKYIHSA+VIHRDLKP N+L Sbjct: 114 YDGLYCYQELIDYDLAKVIHSSVQLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNIL 173 Query: 244 LNANCDLKICDFGLAR---------PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDV 396 N LKICDFGLAR S+ +T YV TRWYRAPELLL++ YS ++D+ Sbjct: 174 CTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDI 233 Query: 397 WSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 W+VGCI E R P+F GRD MHQ+ I +V+GTP D L Sbjct: 234 WAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDKDIL 274
>MK15_HUMAN (Q8TD08) Mitogen-activated protein kinase 15 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 8) Length = 544 Score = 169 bits (429), Expect = 3e-42 Identities = 78/156 (50%), Positives = 107/156 (68%), Gaps = 6/156 (3%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 D+Y+ E MDTDL+ +IR L + H + YQLLR +++HS +V+HRD KPSN+LL+ Sbjct: 87 DIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLD 146 Query: 250 ANCDLKICDFGLAR------PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGC 411 ANC +K+CDFGLAR E +TEYV TRWYRAPE+LL+S Y+ +D+WS+GC Sbjct: 147 ANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGC 206 Query: 412 IFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 I E++ PLFPG +HQ+ LI E I P+++DL Sbjct: 207 ILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDL 242
>JNK1_ANCCA (Q9U6D2) Stress-activated protein kinase JNK-1 (EC 2.7.11.24)| Length = 376 Score = 166 bits (421), Expect = 3e-41 Identities = 82/149 (55%), Positives = 107/149 (71%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + FND+YI ELMD +L +I+ +L E Y LYQ+L G+K++HSA +IHRDLKPSN Sbjct: 99 EEFNDLYIVMELMDANLCQVIQ--MDLDHERLSYLLYQMLCGIKHLHSAGIIHRDLKPSN 156 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 +++ ++C LKI DFGLAR + E+ MMT YVVTR+YRAPE++L Y +DVWSVGCIF Sbjct: 157 IVVKSDCTLKILDFGLARTAVEAFMMTPYVVTRYYRAPEVIL-GMGYGENVDVWSVGCIF 215 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTP 504 ELI LFPG DH+ Q I E++GTP Sbjct: 216 GELIRGRVLFPGADHIDQWTRIIELLGTP 244
>KKQ1_YEAST (P36005) Probable serine/threonine-protein kinase YKL161C (EC| 2.7.11.1) Length = 433 Score = 166 bits (419), Expect = 5e-41 Identities = 76/158 (48%), Positives = 110/158 (69%), Gaps = 5/158 (3%) Frame = +1 Query: 61 SFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNL 240 + N VY+ ELM+ DL IIRS Q L + H Q F+YQ+L LKYIHSANV+H DLKP NL Sbjct: 100 ALNGVYLYEELMECDLSQIIRSEQRLEDAHFQSFIYQILCALKYIHSANVLHCDLKPKNL 159 Query: 241 LLNANCDLKICDFGLARPSSESDMMTE-----YVVTRWYRAPELLLNSTDYSAAIDVWSV 405 L+N++C LKIC+FGL+ SE+ + + Y+ + WY+APE+LLN + + A+D+WS Sbjct: 160 LVNSDCQLKICNFGLSCSYSENHKVNDGFIKGYITSIWYKAPEILLNYQECTKAVDIWST 219 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 GCI EL+ R P+F G+D++ + I +++GTP ++ L Sbjct: 220 GCILAELLGRKPMFEGKDYVDHLNHILQILGTPPEETL 257
>MK12_BRARE (O42376) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Stress-activated protein kinase 3) Length = 363 Score = 165 bits (418), Expect = 6e-41 Identities = 78/150 (52%), Positives = 105/150 (70%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 F+D Y+ M TDL +++ + LSEE QY +YQ+L+GLKYIH+A +IHRDLKP NL Sbjct: 100 FHDFYLVMPFMGTDLGKLMKM-ERLSEERVQYLVYQMLKGLKYIHAAGIIHRDLKPGNLA 158 Query: 244 LNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 +N C+LKI DFGLAR + MT YVVTRWYRAPE++L+ Y+ +D+WSVGCI E Sbjct: 159 INEECELKILDFGLARQTDSE--MTGYVVTRWYRAPEVILSWMHYTQTVDIWSVGCIMAE 216 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 ++ PLF G DH+ Q+ I +V GTP+ + Sbjct: 217 MLLGKPLFKGHDHLDQLMEIMKVTGTPSKE 246
>MK12_RAT (Q63538) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 163 bits (413), Expect = 2e-40 Identities = 79/154 (51%), Positives = 105/154 (68%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P F D Y+ M TDL +++ ++ LSE+ Q+ +YQ+L+GLKYIH+A VIHRD Sbjct: 95 PDETLDDFTDFYLVMPFMGTDLGKLMK-HETLSEDRIQFLVYQMLKGLKYIHAAGVIHRD 153 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKP NL +N +C+LKI DFGLAR + MT YVVTRWYRAPE++LN Y+ +D+WS Sbjct: 154 LKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNWMRYTQTVDIWS 211 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI E+I LF G DH+ Q++ I +V GTP Sbjct: 212 VGCIMAEMITGKILFKGNDHLDQLKEIMKVTGTP 245
>MK08A_CYPCA (Q90327) Mitogen-activated protein kinase 8A (EC 2.7.11.24)| (Stress-activated protein kinase JNKa) (c-Jun N-terminal kinase A) Length = 427 Score = 162 bits (411), Expect = 4e-40 Identities = 77/150 (51%), Positives = 106/150 (70%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 F DVY+ ELMD +L +I+ EL E Y LYQ+L G+K++HSA +IHRDLKPSN++ Sbjct: 101 FQDVYLVMELMDANLCQVIQ--MELDHERLSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 158 Query: 244 LNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 + ++C LKI DFGLAR ++ +MT YVVTR+YRAPE++L Y A +D+WSVGCI E Sbjct: 159 VKSDCTLKILDFGLARTAATGLLMTPYVVTRYYRAPEVIL-GMGYQANVDIWSVGCILAE 217 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 ++ LFPGRD++ Q + E +GTPT + Sbjct: 218 MVRHKILFPGRDYIDQWNKVIEQLGTPTQE 247
>JNK1_CAEEL (Q8WQG9) Stress-activated protein kinase jnk-1 (EC 2.7.11.24)| Length = 463 Score = 162 bits (411), Expect = 4e-40 Identities = 80/147 (54%), Positives = 105/147 (71%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 FND+YI ELMD +L +I+ +L E Y LYQ+L G++++HSA +IHRDLKPSN++ Sbjct: 194 FNDLYIVMELMDANLCQVIQ--MDLDHERLSYLLYQMLCGIRHLHSAGIIHRDLKPSNIV 251 Query: 244 LNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 + ++C LKI DFGLAR + E+ MMT YVVTR+YRAPE++L Y +DVWS+GCIF E Sbjct: 252 VRSDCTLKILDFGLARTAIEAFMMTPYVVTRYYRAPEVIL-GMGYKENVDVWSIGCIFGE 310 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTP 504 LI LFPG DH+ Q I E +GTP Sbjct: 311 LIRGRVLFPGGDHIDQWTRIIEQLGTP 337
>MK12_MOUSE (O08911) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 162 bits (411), Expect = 4e-40 Identities = 77/147 (52%), Positives = 104/147 (70%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 F D Y+ M TDL +++ ++ LSE+ Q+ +YQ+L+GLKYIH+A VIHRDLKP NL Sbjct: 102 FTDFYLVMPFMGTDLGKLMK-HETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLA 160 Query: 244 LNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 +N +C+LKI DFGLAR + MT YVVTRWYRAPE++LN Y+ +D+WSVGCI E Sbjct: 161 VNEDCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAE 218 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTP 504 +I LF G DH+ Q++ I ++ GTP Sbjct: 219 MITGKILFKGNDHLDQLKEIMKITGTP 245
>PMK2_CAEEL (Q8MXI4) Mitogen-activated protein kinase pmk-2 (EC 2.7.11.24) (p38| MAP kinase 2) (Stress-activated protein kinase pmk-2) Length = 419 Score = 162 bits (410), Expect = 5e-40 Identities = 83/174 (47%), Positives = 111/174 (63%), Gaps = 17/174 (9%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P S N+VY + LM +DL +I++ Q L++E Q +YQ+LRGLKYIHSA +IHRD Sbjct: 117 PDPDASSLNNVYFVSVLMGSDLQNIMKI-QRLTDEQIQLLIYQVLRGLKYIHSAGIIHRD 175 Query: 223 LKPSNLLLNANCDLK-----------------ICDFGLARPSSESDMMTEYVVTRWYRAP 351 LKPSN+ +N C++K I DFGLAR ++ MT YV TRWYRAP Sbjct: 176 LKPSNIAVNERCEVKVFLSFSQLSFLILSFFKILDFGLAR--AQDAEMTGYVATRWYRAP 233 Query: 352 ELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 E++LN Y+ +DVWSVGCI EL++ PLFPG DH+ Q+ I V+GTP ++ Sbjct: 234 EIMLNWMHYTQTVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEE 287
>MK08B_CYPCA (O42099) Mitogen-activated protein kinase 8B (EC 2.7.11.24)| (Stress-activated protein kinase JNKb) (c-Jun N-terminal kinase B) Length = 427 Score = 162 bits (409), Expect = 7e-40 Identities = 78/157 (49%), Positives = 107/157 (68%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + F DVY+ ELMD +L +I+ EL E Y LYQ+L G K++HSA +IHRD Sbjct: 94 PQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERLSYLLYQMLCGTKHLHSAGIIHRD 151 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSN+++ ++C LKI DFGLAR ++ +MT YVVTR+YRAPE++L Y A +DVWS Sbjct: 152 LKPSNIVVKSDCTLKILDFGLARTAATGLLMTPYVVTRYYRAPEVIL-GMGYQANVDVWS 210 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 VGCI E++ + LFPG DH+ Q + E +GTP+ + Sbjct: 211 VGCIMAEMVRGSVLFPGSDHIDQWNKVIEQLGTPSQE 247
>MK13_MOUSE (Q9Z1B7) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 366 Score = 161 bits (408), Expect = 9e-40 Identities = 77/154 (50%), Positives = 105/154 (68%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + +SF+D Y+ M TDL I+ E SE+ QY +YQ+L+GLKYIHSA ++HRD Sbjct: 93 PASSLRSFHDFYLVMPFMQTDLQKIM--GMEFSEDKVQYLVYQMLKGLKYIHSAGIVHRD 150 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKP NL +N +C+LKI DFGLAR + MT YVVTRWYRAPE++L+ Y+ +D+WS Sbjct: 151 LKPGNLAVNEDCELKILDFGLARHTDTE--MTGYVVTRWYRAPEVILSWMHYNQTVDIWS 208 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI E++ LF G+D++ Q+ I +V G P Sbjct: 209 VGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242
>MK08_BRARE (Q9DGD9) Mitogen-activated protein kinase 8 (EC 2.7.11.24)| (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) Length = 384 Score = 161 bits (408), Expect = 9e-40 Identities = 76/157 (48%), Positives = 108/157 (68%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + F DVY+ ELMD +L +I+ EL E Y LYQ+L G+K++H+A +IHRD Sbjct: 94 PQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERLSYLLYQMLCGIKHLHAAGIIHRD 151 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSN+++ ++C LKI DFGLAR ++ +MT YVVTR+YRAPE++L Y A +DVWS Sbjct: 152 LKPSNIVVKSDCTLKILDFGLARTAATGLLMTPYVVTRYYRAPEVIL-GMGYQANVDVWS 210 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 +GCI E++ + LFPG DH+ Q + E +GTP+ + Sbjct: 211 IGCIMAEMVRGSVLFPGTDHIDQWNKVIEQLGTPSQE 247
>MK13_PANTR (Q9N272) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) Length = 365 Score = 161 bits (408), Expect = 9e-40 Identities = 78/154 (50%), Positives = 105/154 (68%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + ++F+D Y+ M TDL I+ E SEE QY +YQ+L+GLKYIHSA V+HRD Sbjct: 93 PASSLRNFHDFYLVMXFMQTDLQKIMX--MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD 150 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKP NL +N +C+LKI DFGLAR + MT YVVTRWYRAPE++L+ Y+ +D+WS Sbjct: 151 LKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTRWYRAPEVILSWMHYNQTVDIWS 208 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI E++ LF G+D++ Q+ I +V G P Sbjct: 209 VGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242
>MK12_HUMAN (P53778) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 161 bits (408), Expect = 9e-40 Identities = 76/154 (49%), Positives = 105/154 (68%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P F D Y+ M TDL +++ +++L E+ Q+ +YQ+L+GL+YIH+A +IHRD Sbjct: 95 PDETLDDFTDFYLVMPFMGTDLGKLMK-HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRD 153 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKP NL +N +C+LKI DFGLAR + MT YVVTRWYRAPE++LN Y+ +D+WS Sbjct: 154 LKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNWMRYTQTVDIWS 211 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI E+I LF G DH+ Q++ I +V GTP Sbjct: 212 VGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245
>MK13_RAT (Q9WTY9) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 366 Score = 161 bits (407), Expect = 1e-39 Identities = 77/154 (50%), Positives = 103/154 (66%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P ++F D Y+ M TDL I+ E SEE QY +YQ+L+GLKYIHSA ++HRD Sbjct: 93 PATSVRNFQDFYLVMPFMQTDLQKIM--GMEFSEEKVQYLVYQMLKGLKYIHSAGIVHRD 150 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKP NL +N +C+LKI DFGLAR + MT YVVTRWYRAPE++L+ Y+ +D+WS Sbjct: 151 LKPGNLAVNEDCELKILDFGLARHTDAE--MTGYVVTRWYRAPEVILSWMHYNQTVDIWS 208 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI E++ LF G+D++ Q+ I +V G P Sbjct: 209 VGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242
>MK10_HUMAN (P53779) Mitogen-activated protein kinase 10 (EC 2.7.11.24)| (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) Length = 464 Score = 161 bits (407), Expect = 1e-39 Identities = 78/154 (50%), Positives = 105/154 (68%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + F DVY+ ELMD +L +I+ EL E Y LYQ+L G+K++HSA +IHRD Sbjct: 132 PQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIHRD 189 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSN+++ ++C LKI DFGLAR + S MMT YVVTR+YRAPE++L Y +D+WS Sbjct: 190 LKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWS 248 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI E++ LFPGRD++ Q + E +GTP Sbjct: 249 VGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282
>MK13_HUMAN (O15264) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 365 Score = 160 bits (406), Expect = 2e-39 Identities = 78/154 (50%), Positives = 104/154 (67%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + ++F D Y+ M TDL I+ E SEE QY +YQ+L+GLKYIHSA V+HRD Sbjct: 93 PASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRD 150 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKP NL +N +C+LKI DFGLAR + MT YVVTRWYRAPE++L+ Y+ +D+WS Sbjct: 151 LKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTRWYRAPEVILSWMHYNQTVDIWS 208 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI E++ LF G+D++ Q+ I +V G P Sbjct: 209 VGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 242
>MK08_XENLA (Q8QHK8) Mitogen-activated protein kinase 8 (EC 2.7.11.24)| (Stress-activated protein kinase JNK1) Length = 426 Score = 160 bits (406), Expect = 2e-39 Identities = 78/149 (52%), Positives = 103/149 (69%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + F D+YI ELMD +L +I+ EL E Y LYQ+L G+K++HSA +IHRDLKPSN Sbjct: 99 EEFQDLYIVMELMDANLCQVIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN 156 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 +++ ++C LKI DFGLAR + S MMT YVVTR+YRAPE++L Y +D+WSVGCI Sbjct: 157 IVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIL 215 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTP 504 E+I LFPG DH+ Q + E +GTP Sbjct: 216 GEMIKGGVLFPGTDHIDQWNKVIEQLGTP 244
>MK15_RAT (Q9Z2A6) Mitogen-activated protein kinase 15 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 7) Length = 547 Score = 160 bits (405), Expect = 2e-39 Identities = 77/156 (49%), Positives = 105/156 (67%), Gaps = 6/156 (3%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 D+Y+ E MDTDL+ +I+ + L + H + YQLLR K+IHS VIHRD KP+N+LL+ Sbjct: 88 DIYLVFESMDTDLNAVIQKGRLLEDIHKRCIFYQLLRATKFIHSGRVIHRDQKPANVLLD 147 Query: 250 ANCDLKICDFGLARPSSE------SDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGC 411 A C +K+CDFGLAR S+ +TEYV TRWYRAPE+LL+S Y+ +D+WS+GC Sbjct: 148 AACRVKLCDFGLARSLSDFPEGPGGQALTEYVATRWYRAPEVLLSSRWYTPGVDMWSLGC 207 Query: 412 IFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 I E++ PLFPG HQ+ LI E I P+ ++L Sbjct: 208 ILGEMLRGQPLFPGTSTFHQLELILETIPLPSMEEL 243
>JNK_DROME (P92208) Stress-activated protein kinase JNK (EC 2.7.11.24) (dJNK)| (Protein basket) Length = 372 Score = 160 bits (404), Expect = 3e-39 Identities = 77/150 (51%), Positives = 105/150 (70%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + F DVY+ ELMD +L +I+ +L + Y LYQ+L G+K++HSA +IHRDLKPSN Sbjct: 97 EEFQDVYLVMELMDANLCQVIQ--MDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSN 154 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 +++ A+C LKI DFGLAR + + MMT YVVTR+YRAPE++L Y+ +D+WSVGCI Sbjct: 155 IVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL-GMGYTENVDIWSVGCIM 213 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTPT 507 E+I LFPG DH+ Q I E +GTP+ Sbjct: 214 GEMIRGGVLFPGTDHIDQWNKIIEQLGTPS 243
>MK09_MOUSE (Q9WTU6) Mitogen-activated protein kinase 9 (EC 2.7.11.24)| (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) Length = 423 Score = 160 bits (404), Expect = 3e-39 Identities = 77/155 (49%), Positives = 106/155 (68%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + F DVY+ ELMD +L +I + EL E Y LYQ+L G+K++HSA +IHRD Sbjct: 94 PQKTLEEFQDVYLVMELMDANLCQVI--HMELDHERMSYLLYQMLCGIKHLHSAGIIHRD 151 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSN+++ ++C LKI DFGLAR + + MMT YVVTR+YRAPE++L Y +D+WS Sbjct: 152 LKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWS 210 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPT 507 VGCI E++ LFPGRD++ Q + E +GTP+ Sbjct: 211 VGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPS 245
>MK08_MOUSE (Q91Y86) Mitogen-activated protein kinase 8 (EC 2.7.11.24)| (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) Length = 384 Score = 159 bits (403), Expect = 3e-39 Identities = 78/149 (52%), Positives = 104/149 (69%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + F DVYI ELMD +L +I+ EL E Y LYQ+L G+K++HSA +IHRDLKPSN Sbjct: 99 EEFQDVYIVMELMDANLCQVIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN 156 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 +++ ++C LKI DFGLAR + S MMT YVVTR+YRAPE++L Y +D+WSVGCI Sbjct: 157 IVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDLWSVGCIM 215 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTP 504 E++ LFPGRD++ Q + E +GTP Sbjct: 216 GEMVCHKILFPGRDYIDQWNKVIEQLGTP 244
>MK10_RAT (P49187) Mitogen-activated protein kinase 10 (EC 2.7.11.24)| (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (SAPK-beta) (p54-beta) Length = 464 Score = 159 bits (403), Expect = 3e-39 Identities = 77/154 (50%), Positives = 104/154 (67%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + F DVY+ ELMD +L +I+ EL E Y LYQ+L +K++HSA +IHRD Sbjct: 132 PQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSYLLYQMLSAIKHLHSAGIIHRD 189 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSN+++ ++C LKI DFGLAR + S MMT YVVTR+YRAPE++L Y +D+WS Sbjct: 190 LKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWS 248 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI E++ LFPGRD++ Q + E +GTP Sbjct: 249 VGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282
>MK08_HUMAN (P45983) Mitogen-activated protein kinase 8 (EC 2.7.11.24)| (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46) Length = 427 Score = 159 bits (403), Expect = 3e-39 Identities = 78/149 (52%), Positives = 104/149 (69%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + F DVYI ELMD +L +I+ EL E Y LYQ+L G+K++HSA +IHRDLKPSN Sbjct: 99 EEFQDVYIVMELMDANLCQVIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN 156 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 +++ ++C LKI DFGLAR + S MMT YVVTR+YRAPE++L Y +D+WSVGCI Sbjct: 157 IVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDLWSVGCIM 215 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTP 504 E++ LFPGRD++ Q + E +GTP Sbjct: 216 GEMVCHKILFPGRDYIDQWNKVIEQLGTP 244
>MK08_RAT (P49185) Mitogen-activated protein kinase 8 (EC 2.7.11.24)| (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (SAPK gamma) (p54 gamma) Length = 411 Score = 159 bits (401), Expect = 6e-39 Identities = 78/149 (52%), Positives = 104/149 (69%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + F DVYI ELMD +L +I+ EL E Y LYQ+L G+K++HSA +IHRDLKPSN Sbjct: 99 EEFQDVYIVMELMDANLCQVIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN 156 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 +++ ++C LKI DFGLAR + S MMT YVVTR+YRAPE++L Y +D+WSVGCI Sbjct: 157 IVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDLWSVGCIM 215 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTP 504 E++ LFPGRD++ Q + E +GTP Sbjct: 216 GEMVCLKILFPGRDYIDQWNKVIEQLGTP 244
>MK10_MOUSE (Q61831) Mitogen-activated protein kinase 10 (EC 2.7.11.24)| (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) Length = 464 Score = 159 bits (401), Expect = 6e-39 Identities = 77/154 (50%), Positives = 104/154 (67%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + F DVY+ ELMD +L +I+ EL E Y LYQ+L G+K++HSA +IHRD Sbjct: 132 PQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIHRD 189 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSN+++ ++C LKI DFGLAR + S MMT YVVTR+YRAPE++L Y +D+WS Sbjct: 190 LKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWS 248 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 VGCI E++ LFPGR ++ Q + E +GTP Sbjct: 249 VGCIMGEMVRHKILFPGRSYIDQWNKVIEQLGTP 282
>MK09_RAT (P49186) Mitogen-activated protein kinase 9 (EC 2.7.11.24)| (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (SAPK-alpha) (p54-alpha) Length = 423 Score = 157 bits (396), Expect = 2e-38 Identities = 76/155 (49%), Positives = 104/155 (67%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + F DVY+ ELMD +L +I + EL E Y LYQ+L G+K++HSA +IHRD Sbjct: 94 PQKTLEEFQDVYLVMELMDANLCQVI--HMELDHERMSYLLYQMLCGIKHLHSAGIIHRD 151 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSN+++ ++C LKI DFGLAR + + MMT YVVTR+YRAPE++L Y +D+WS Sbjct: 152 LKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWS 210 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPT 507 VGCI EL+ +F G DH+ Q + E +GTP+ Sbjct: 211 VGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPS 245
>MK09_HUMAN (P45984) Mitogen-activated protein kinase 9 (EC 2.7.11.24)| (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55) Length = 424 Score = 157 bits (396), Expect = 2e-38 Identities = 76/155 (49%), Positives = 104/155 (67%) Frame = +1 Query: 43 PPAIPQSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRD 222 P + F DVY+ ELMD +L +I + EL E Y LYQ+L G+K++HSA +IHRD Sbjct: 94 PQKTLEEFQDVYLVMELMDANLCQVI--HMELDHERMSYLLYQMLCGIKHLHSAGIIHRD 151 Query: 223 LKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 LKPSN+++ ++C LKI DFGLAR + + MMT YVVTR+YRAPE++L Y +D+WS Sbjct: 152 LKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWS 210 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPT 507 VGCI EL+ +F G DH+ Q + E +GTP+ Sbjct: 211 VGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPS 245
>JNK_SUBDO (Q966Y3) Stress-activated protein kinase JNK (EC 2.7.11.24)| Length = 361 Score = 157 bits (396), Expect = 2e-38 Identities = 76/147 (51%), Positives = 103/147 (70%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 F DVYI ELMD +L +I EL + Y LYQLL G+K++HSA +IHRDLKPSN++ Sbjct: 97 FQDVYIVMELMDANLCRVI--GIELDHDRMSYLLYQLLCGIKHLHSAGIIHRDLKPSNIV 154 Query: 244 LNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 + +C LKI DFGLAR + ++ MT YVVTR+YRAPE+++ Y +D+WSVGCIF E Sbjct: 155 VKEDCSLKILDFGLARTADQTFNMTPYVVTRYYRAPEVIV-GMKYKENVDIWSVGCIFAE 213 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTP 504 +I L PG+D++ Q +T+V+GTP Sbjct: 214 MIRGDILLPGKDYIDQWNKVTQVLGTP 240
>MK09_CHICK (P79996) Mitogen-activated protein kinase 9 (EC 2.7.11.24)| (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) Length = 382 Score = 156 bits (395), Expect = 3e-38 Identities = 75/150 (50%), Positives = 103/150 (68%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + F DVY+ ELMD +L +I + EL E Y LYQ+L G+K++HSA +IHRDLKPSN Sbjct: 99 EEFQDVYLVMELMDANLCQVI--HMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN 156 Query: 238 LLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 +++ ++C LKI DFGLAR + + MMT YVVTR+YRAPE++L Y +D+WSVGCI Sbjct: 157 IVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIM 215 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTPT 507 EL+ +F G DH+ Q + E +GTP+ Sbjct: 216 GELVKGCVIFQGTDHIDQWNKVIEQLGTPS 245
>MK15_MOUSE (Q80Y86) Mitogen-activated protein kinase 15 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 7) Length = 549 Score = 156 bits (394), Expect = 4e-38 Identities = 74/156 (47%), Positives = 104/156 (66%), Gaps = 6/156 (3%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 D+Y+ E MDTDL+ +I+ + L + H + YQLLR K+IHS VIHRD KP+N+LL+ Sbjct: 88 DIYLVFESMDTDLNAVIQKGRLLKDIHKRCIFYQLLRATKFIHSGRVIHRDQKPANVLLD 147 Query: 250 ANCDLKICDFGLARPSSE------SDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGC 411 + C +K+CDFGLAR + +TEYV TRWYRAPE+LL+S Y+ +D+WS+GC Sbjct: 148 SACRVKLCDFGLARSLGDLPEGPGGQALTEYVATRWYRAPEVLLSSRWYTPGVDMWSLGC 207 Query: 412 IFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 I E++ PLFPG HQ+ LI + I P+ ++L Sbjct: 208 ILGEMLRGQPLFPGTSTFHQLELILKTIPLPSMEEL 243
>MK14C_DROME (P83100) Putative mitogen-activated protein kinase 14C (EC| 2.7.11.24) (MAP kinase p38c) Length = 356 Score = 155 bits (391), Expect = 9e-38 Identities = 78/156 (50%), Positives = 105/156 (67%), Gaps = 1/156 (0%) Frame = +1 Query: 43 PPAIPQ-SFNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHR 219 PPA F VY+ T LMD DLH RS + +S++ + LYQ+LRGLKYIHSA V+HR Sbjct: 88 PPAHNMMEFQQVYLVTHLMDADLHRYSRSKR-MSDQEIRIILYQILRGLKYIHSAGVVHR 146 Query: 220 DLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVW 399 DLKP N+ +N N +++I DFGL+R + D MT++V T WY APE++ Y+ AIDVW Sbjct: 147 DLKPCNIAVNGNSEVRILDFGLSRMCA--DKMTDHVGTMWYLAPEIIFLRGQYTKAIDVW 204 Query: 400 SVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPT 507 SVGCI ELI LF G +++ Q+R + ++GTPT Sbjct: 205 SVGCILAELITDRVLFRGENYVSQIRCLINIMGTPT 240
>YPC2_CAEEL (Q11179) Putative serine/threonine-protein kinase C05D10.2 in| chromosome III (EC 2.7.11.24) Length = 470 Score = 152 bits (383), Expect = 7e-37 Identities = 71/162 (43%), Positives = 105/162 (64%), Gaps = 9/162 (5%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 D+Y+A E M+ DLH++I+ L + H QY + QL R ++++HS NV+HRDLKPSN+LL+ Sbjct: 87 DIYLAFEFMEADLHNVIKKGSILKDVHKQYIMCQLFRAIRFLHSGNVLHRDLKPSNVLLD 146 Query: 250 ANCDLKICDFGLARPSSESD---------MMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 A+C +K+ DFGLAR S + +TEYV TRWYR+PE+LL + Y+ +D+WS Sbjct: 147 ADCRVKLADFGLARSLSSLEDYPEGQKMPDLTEYVATRWYRSPEILLAAKRYTKGVDMWS 206 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDLGFI 528 +GCI E++ LFPG ++Q+ I I P+ D+ I Sbjct: 207 LGCILAEMLIGRALFPGSSTINQIERIMNTIAKPSRADIASI 248
>MK06_RAT (P27704) Mitogen-activated protein kinase 6 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 3) (ERK-3) (p55-MAPK) Length = 720 Score = 148 bits (374), Expect = 8e-36 Identities = 78/155 (50%), Positives = 104/155 (67%), Gaps = 5/155 (3%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 N VYI E M+TDL +++ L EEH + F+YQLLRGLKYIHSANV+HRDLKP+NL + Sbjct: 102 NSVYIVQEYMETDLANVLEQGP-LLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFI 160 Query: 247 NA-NCDLKICDFGLARPS----SESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGC 411 N + LKI DFGLAR S ++E +VT+WYR+P LLL+ +Y+ AID+W+ GC Sbjct: 161 NTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGC 220 Query: 412 IFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 IF E++ LF G + QM+LI E I ++D Sbjct: 221 IFAEMLTGKTLFAGAHELEQMQLILESIPVVHEED 255
>MK06_HUMAN (Q16659) Mitogen-activated protein kinase 6 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) Length = 721 Score = 148 bits (374), Expect = 8e-36 Identities = 78/155 (50%), Positives = 104/155 (67%), Gaps = 5/155 (3%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 N VYI E M+TDL +++ L EEH + F+YQLLRGLKYIHSANV+HRDLKP+NL + Sbjct: 102 NSVYIVQEYMETDLANVLEQGP-LLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFI 160 Query: 247 NA-NCDLKICDFGLARPS----SESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGC 411 N + LKI DFGLAR S ++E +VT+WYR+P LLL+ +Y+ AID+W+ GC Sbjct: 161 NTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGC 220 Query: 412 IFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 IF E++ LF G + QM+LI E I ++D Sbjct: 221 IFAEMLTGKTLFAGAHELEQMQLILESIPVVHEED 255
>PMK3_CAEEL (O44514) Mitogen-activated protein kinase pmk-3 (EC 2.7.11.24) (p38| MAP kinase 3) (Stress-activated protein kinase pmk-3) Length = 474 Score = 147 bits (372), Expect = 1e-35 Identities = 73/166 (43%), Positives = 106/166 (63%), Gaps = 7/166 (4%) Frame = +1 Query: 37 VIPPAIPQSFNDVYIATELMDTDLHHIIRSNQE-----LSEEHCQYFLYQLLRGLKYIHS 201 + P F DVY+ TE L+ I++ ++ L++EH ++ +YQ++R LKYIHS Sbjct: 186 IYTPDEENDFRDVYVVTEFAGRSLYQILKQQRDYGRRVLTDEHIKFIIYQIIRALKYIHS 245 Query: 202 ANVIHRDLKPSNLLLNANCDLKICDFGLARPSSESD-MMTEYVVTRWYRAPELLLNSTD- 375 AN+IHRDLKP NL L + DL I DFGLAR + D +T+YV TRWYR+PE++ D Sbjct: 246 ANIIHRDLKPGNLALTDDSDLMILDFGLARSLEKKDTSLTQYVQTRWYRSPEVIYWKIDS 305 Query: 376 YSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 Y+ D+WS+GCI EL+ PLFPG + Q + IT++ G+P ++ Sbjct: 306 YTNLADMWSLGCIAAELLTGEPLFPGDEPNAQYQRITQLCGSPDEE 351
>MK06_MOUSE (Q61532) Mitogen-activated protein kinase 6 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 3) (ERK-3) Length = 720 Score = 147 bits (371), Expect = 2e-35 Identities = 77/155 (49%), Positives = 104/155 (67%), Gaps = 5/155 (3%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 N VYI E M+TDL +++ L EEH + F+YQLLRGLKYIHSANV+HRDLKP+NL + Sbjct: 102 NSVYIVQEYMETDLANVLEQGP-LLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFI 160 Query: 247 NA-NCDLKICDFGLARPS----SESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGC 411 N + LKI DFGLAR S ++E +VT+WYR+P LLL+ +Y+ AID+W+ GC Sbjct: 161 NTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGC 220 Query: 412 IFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 IF E++ LF G + QM+LI + I ++D Sbjct: 221 IFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEED 255
>MK04_HUMAN (P31152) Mitogen-activated protein kinase 4 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) Length = 557 Score = 142 bits (358), Expect = 6e-34 Identities = 74/156 (47%), Positives = 103/156 (66%), Gaps = 5/156 (3%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 F+ YI E M+TDL ++ L+EEH + F+YQLLRGLKYIHSANV+HRDLKP+N+ Sbjct: 98 FSVAYIVQEYMETDLARLLEQGT-LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIF 156 Query: 244 LNA-NCDLKICDFGLAR----PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVG 408 ++ + LKI DFGLAR S ++E +VT+WYR+P LLL+ +Y+ AID+W+ G Sbjct: 157 ISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAG 216 Query: 409 CIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 CI E++ LF G + QM+LI E I ++D Sbjct: 217 CILAEMLTGRMLFAGAHELEQMQLILETIPVIREED 252
>MK04_RAT (Q63454) Mitogen-activated protein kinase 4 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) (MNK2) (Fragment) Length = 274 Score = 141 bits (355), Expect = 1e-33 Identities = 73/156 (46%), Positives = 104/156 (66%), Gaps = 5/156 (3%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 F+ YI E M+TDL ++ L+EEH + F+YQLLRGLKYIHSANV+HRDLKP+N+ Sbjct: 72 FSVAYIVQEYMETDLACLLEQGT-LTEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIF 130 Query: 244 LNA-NCDLKICDFGLARPS----SESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVG 408 ++ + LKI DFGLAR + S ++E +VT+WYR+P LLL+ +Y+ AID+W+ G Sbjct: 131 ISTEDLVLKIGDFGLARIADQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAG 190 Query: 409 CIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 CI E++ LF G + QM+LI + I ++D Sbjct: 191 CILAEMLTGKMLFAGAHELEQMQLILDTIPVVREED 226
>MK04_MOUSE (Q6P5G0) Mitogen-activated protein kinase 4 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 4) (ERK-4) Length = 583 Score = 139 bits (350), Expect = 5e-33 Identities = 72/156 (46%), Positives = 103/156 (66%), Gaps = 5/156 (3%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 F+ YI E M+TDL ++ L+E+H + F+YQLLRGLKYIHSANV+HRDLKP+N+ Sbjct: 98 FSVAYIVQEYMETDLACLLEQGT-LTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIF 156 Query: 244 LNA-NCDLKICDFGLAR----PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVG 408 ++ + LKI DFGLAR S ++E +VT+WYR+P LLL+ +Y+ AID+W+ G Sbjct: 157 ISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAG 216 Query: 409 CIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 CI E++ LF G + QM+LI + I ++D Sbjct: 217 CILAEMLTGKMLFAGAHELEQMQLILDTIPVVREED 252
>CCRK_HUMAN (Q8IZL9) Cell cycle-related kinase (EC 2.7.11.22)| (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) Length = 346 Score = 138 bits (347), Expect = 1e-32 Identities = 67/145 (46%), Positives = 98/145 (67%), Gaps = 3/145 (2%) Frame = +1 Query: 79 IATELMDTDLHHIIRSNQE-LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNAN 255 +A E M +DL ++R Q L++ + +L LL+G+ + H+ N++HRDLKP+NLL++A+ Sbjct: 79 LAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS 138 Query: 256 CDLKICDFGLARPSSE--SDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 LKI DFGLAR S S + T V TRWYRAPELL + Y +D+WSVGCI EL+ Sbjct: 139 GQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELL 198 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTP 504 N +PLFPG++ + Q+ + ++GTP Sbjct: 199 NGSPLFPGKNDIEQLCYVLRILGTP 223
>CCRK_PONPY (Q5R7I7) Cell cycle-related kinase (EC 2.7.11.22)| Length = 346 Score = 137 bits (345), Expect = 2e-32 Identities = 66/145 (45%), Positives = 98/145 (67%), Gaps = 3/145 (2%) Frame = +1 Query: 79 IATELMDTDLHHIIRSNQE-LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNAN 255 +A E M +DL ++R Q L++ + +L LL+G+ + H+ N++HRDLKP+NLL++A+ Sbjct: 79 LAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVSFCHANNIVHRDLKPANLLISAS 138 Query: 256 CDLKICDFGLARPSSE--SDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 LKI DFGLAR S S + T V TRWYRAPELL + Y +D+W+VGCI EL+ Sbjct: 139 GQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELL 198 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTP 504 N +PLFPG++ + Q+ + ++GTP Sbjct: 199 NGSPLFPGKNDIEQLCYVLRILGTP 223
>CDC2A_ANTMA (Q38772) Cell division control protein 2 homolog A (EC 2.7.11.22)| (EC 2.7.11.23) Length = 294 Score = 137 bits (345), Expect = 2e-32 Identities = 72/151 (47%), Positives = 97/151 (64%), Gaps = 4/151 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEH--CQYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 +Y+ E +D DL + S E S++ + FLYQ+LRG+ Y HS V+HRDLKP NLL+ Sbjct: 76 LYLVFEYLDLDLKKHMDSCPEFSQDPRLVKMFLYQILRGIAYCHSHRVLHRDLKPQNLLI 135 Query: 247 NANCD-LKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 + + LK+ DFGLAR T VVT WYRAPE+LL S YS +DVWSVGCIF Sbjct: 136 DRRTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFA 195 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 E++N+ PLFPG + ++ I V+GTP ++ Sbjct: 196 EMVNQRPLFPGDSEIDELFKIFRVMGTPNEE 226
>CDC2_DICDI (P34112) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 296 Score = 136 bits (343), Expect = 3e-32 Identities = 70/149 (46%), Positives = 94/149 (63%), Gaps = 1/149 (0%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 N +Y+ E +D DL + S L + + +LYQLL+GL Y H ++HRDLKP NLL+ Sbjct: 78 NRLYLVFEYLDQDLKKYMDSVPALCPQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLI 137 Query: 247 NANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 + LK+ DFGLAR S + T +VT WYRAPE+LL S YS +D+WSVGCIF E Sbjct: 138 DRQGALKLADFGLARAVSIPVRVYTHEIVTLWYRAPEVLLGSKSYSVPVDMWSVGCIFGE 197 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTPTD 510 ++N+ PLF G + Q+ I V+GTP D Sbjct: 198 MLNKKPLFSGDCEIDQIFRIFRVLGTPDD 226
>PCTK1_HUMAN (Q00536) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 136 bits (343), Expect = 3e-32 Identities = 69/144 (47%), Positives = 89/144 (61%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQELSEEH-CQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL + + H + FL+QLLRGL Y H V+HRDLKP NLL+N +L Sbjct: 241 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 300 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR S + + VVT WYR P++LL STDYS ID+W VGCIF E+ P Sbjct: 301 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 360 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG Q+ I ++GTPT++ Sbjct: 361 LFPGSTVEEQLHFIFRILGTPTEE 384
>PCTK1_MOUSE (Q04735) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) (CRK5) Length = 496 Score = 136 bits (342), Expect = 4e-32 Identities = 69/144 (47%), Positives = 89/144 (61%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQELSEEH-CQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL + + H + FL+QLLRGL Y H V+HRDLKP NLL+N +L Sbjct: 241 EYLDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 300 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR S + + VVT WYR P++LL STDYS ID+W VGCIF E+ P Sbjct: 301 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 360 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG Q+ I ++GTPT++ Sbjct: 361 LFPGSTVEEQLHFIFRILGTPTEE 384
>CDC2H_THEPA (Q27032) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 136 bits (342), Expect = 4e-32 Identities = 68/144 (47%), Positives = 93/144 (64%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL ++ + + L + FLYQ+LRG+ Y H ++HRDLKP NLL+N L Sbjct: 80 EYLDQDLKKLLDACDGGLEPTTAKSFLYQILRGISYCHDHRILHRDLKPQNLLINREGVL 139 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR + T VVT WYRAP++L+ S YS A+D+WSVGCIF E+IN P Sbjct: 140 KLADFGLARAFAIPVRSYTHEVVTLWYRAPDVLMGSKKYSTAVDIWSVGCIFAEMINGVP 199 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG Q++ I +++GTP+ D Sbjct: 200 LFPGISEQDQLKRIFKILGTPSVD 223
>CDC2H_THEAN (Q26671) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 135 bits (341), Expect = 5e-32 Identities = 68/144 (47%), Positives = 92/144 (63%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL ++ + + L + FLYQ+LRG+ Y H ++HRDLKP NLL+N L Sbjct: 80 EYLDQDLKKLLDACDGGLEPTTAKSFLYQILRGISYCHDHRILHRDLKPQNLLINREGVL 139 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR + T VVT WYRAP++L+ S YS A+D+WSVGCIF E+IN P Sbjct: 140 KLADFGLARAFAIPVRSYTHEVVTLWYRAPDVLMGSKKYSTAVDIWSVGCIFAEMINGVP 199 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG Q++ I +++GTP D Sbjct: 200 LFPGISEQDQLKRIFKILGTPNVD 223
>CDC2B_ANTMA (Q38773) Cell division control protein 2 homolog B (EC 2.7.11.22)| (EC 2.7.11.23) (Fragment) Length = 280 Score = 135 bits (341), Expect = 5e-32 Identities = 71/151 (47%), Positives = 96/151 (63%), Gaps = 4/151 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEE--HCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 +Y+ E +D DL + S E S++ + FL Q+LRG+ Y HS V+HRDLKP NLL+ Sbjct: 63 LYLVFEYLDLDLKKHMDSCPEFSQDLHMVKMFLCQILRGVAYCHSHRVLHRDLKPQNLLI 122 Query: 247 NANCD-LKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 + + +K+ DFGLAR T VVT WYRAPE+LL S YS +DVWSVGCIF Sbjct: 123 DRGSNTIKLADFGLARAFGIPVRTFTHEVVTLWYRAPEVLLGSRHYSTPVDVWSVGCIFA 182 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 E++N+ PLFPG + ++ I +IGTP +D Sbjct: 183 EMVNQKPLFPGDSEIDELHKIFRIIGTPNED 213
>CDC2_VIGAC (Q41639) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 135 bits (340), Expect = 7e-32 Identities = 71/151 (47%), Positives = 96/151 (63%), Gaps = 4/151 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHCQY--FLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 +Y+ E +D DL + S+ E ++ Q FLYQ+L G+ Y HS V+HRDLKP NLL+ Sbjct: 76 LYLVFEYLDLDLKKHMDSSPEFVKDPRQVKMFLYQILCGIAYCHSHRVLHRDLKPQNLLI 135 Query: 247 NANCD-LKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 + + LK+ DFGLAR T VVT WYRAPE+LL S YS +DVWSVGCIF Sbjct: 136 DRRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFA 195 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 E++NR PLFPG + ++ I ++GTP ++ Sbjct: 196 EMVNRRPLFPGDSEIDELFKIFRILGTPNEE 226
>CDC22_MEDSA (Q05006) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 294 Score = 135 bits (340), Expect = 7e-32 Identities = 70/151 (46%), Positives = 97/151 (64%), Gaps = 4/151 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHCQY--FLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 +Y+ E +D DL + S+ E +++ Q FLYQ+L G+ Y HS V+HRDLKP NLL+ Sbjct: 76 LYLVFEYLDLDLKKFMDSSPEFAKDQRQIKMFLYQILCGIAYCHSHRVLHRDLKPQNLLI 135 Query: 247 NANCD-LKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 + + + +K+ DFGLAR T VVT WYRAPE+LL S YS +DVWSVGCIF Sbjct: 136 DRSSNAVKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFA 195 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 E+IN+ PLFPG + ++ I + GTP ++ Sbjct: 196 EMINQRPLFPGDSEIDELFKIFRITGTPNEE 226
>PCTK1_RAT (Q63686) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 135 bits (339), Expect = 9e-32 Identities = 69/144 (47%), Positives = 88/144 (61%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQELSEEH-CQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL + + H + FL+QLLRGL Y H V+HRDLKP NLL+N +L Sbjct: 241 EYLDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 300 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLA S + + VVT WYR P++LL STDYS ID+W VGCIF E+ P Sbjct: 301 KLADFGLAYAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSGQIDMWGVGCIFYEMATGRP 360 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG Q+ I ++GTPT+D Sbjct: 361 LFPGSTVEEQLHFIFRILGTPTED 384
>CDK7_MOUSE (Q03147) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinas Length = 346 Score = 135 bits (339), Expect = 9e-32 Identities = 66/151 (43%), Positives = 97/151 (64%), Gaps = 2/151 (1%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 +++ + + M+TDL II+ N L+ H + ++ L+GL+Y+H ++HRDLKP+NLL Sbjct: 85 SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLL 144 Query: 244 LNANCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 L+ N LK+ DFGLA+ S + T VVTRWYRAPELL + Y +D+W+VGCI Sbjct: 145 LDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILA 204 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 EL+ R P PG + Q+ I E +GTPT++ Sbjct: 205 ELLLRVPFLPGDSDLDQLTRIFETLGTPTEE 235
>CDK7_HUMAN (P50613) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) Length = 346 Score = 135 bits (339), Expect = 9e-32 Identities = 66/151 (43%), Positives = 97/151 (64%), Gaps = 2/151 (1%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 +++ + + M+TDL II+ N L+ H + ++ L+GL+Y+H ++HRDLKP+NLL Sbjct: 85 SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLL 144 Query: 244 LNANCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 L+ N LK+ DFGLA+ S + T VVTRWYRAPELL + Y +D+W+VGCI Sbjct: 145 LDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILA 204 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 EL+ R P PG + Q+ I E +GTPT++ Sbjct: 205 ELLLRVPFLPGDSDLDQLTRIFETLGTPTEE 235
>CDC2_VIGUN (P52389) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 134 bits (338), Expect = 1e-31 Identities = 70/151 (46%), Positives = 96/151 (63%), Gaps = 4/151 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHCQY--FLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 +Y+ E +D DL + S+ E ++ Q FLYQ+L G+ Y HS V+HRDLKP NLL+ Sbjct: 76 LYLVFEYLDLDLKKHMDSSPEFVKDPRQVKMFLYQILCGIAYCHSHRVLHRDLKPQNLLI 135 Query: 247 NANCD-LKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 + + LK+ DFGLAR T VVT WYRAPE+LL S YS +DVWSVGC+F Sbjct: 136 DRRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCLFA 195 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 E++NR PLFPG + ++ I ++GTP ++ Sbjct: 196 EMVNRRPLFPGDSEIDELFKIFRILGTPNEE 226
>CDC2A_ARATH (P24100) Cell division control protein 2 homolog A (EC 2.7.11.22)| (EC 2.7.11.23) Length = 294 Score = 134 bits (338), Expect = 1e-31 Identities = 70/151 (46%), Positives = 97/151 (64%), Gaps = 4/151 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEE--HCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 +Y+ E +D DL + S + S++ + +LYQ+LRG+ Y HS V+HRDLKP NLL+ Sbjct: 76 LYLVFEYLDLDLKKHMDSTPDFSKDLHMIKTYLYQILRGIAYCHSHRVLHRDLKPQNLLI 135 Query: 247 NANCD-LKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 + + LK+ DFGLAR T VVT WYRAPE+LL S YS +D+WSVGCIF Sbjct: 136 DRRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSHHYSTPVDIWSVGCIFA 195 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 E+I++ PLFPG + Q+ I ++GTP +D Sbjct: 196 EMISQKPLFPGDSEIDQLFKIFRIMGTPYED 226
>CDK7_RAT (P51952) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 protein kinase) (P39 Mo15) (Fragment) Length = 329 Score = 134 bits (337), Expect = 2e-31 Identities = 66/151 (43%), Positives = 97/151 (64%), Gaps = 2/151 (1%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 +++ + + M+TDL II+ N L+ H + ++ L+GL+Y+H ++HRDLKP+NLL Sbjct: 77 SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLL 136 Query: 244 LNANCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 L+ N LK+ DFGLA+ S + T VVTRWYRAPELL + Y +D+W+VGCI Sbjct: 137 LDENGVLKLADFGLAKSFGSPNWAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILA 196 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 EL+ R P PG + Q+ I E +GTPT++ Sbjct: 197 ELLLRVPFLPGDSDLDQLTRIFETLGTPTEE 227
>CCRK_RAT (Q4KM34) Cell cycle-related kinase (EC 2.7.11.22)| Length = 346 Score = 134 bits (337), Expect = 2e-31 Identities = 65/146 (44%), Positives = 96/146 (65%), Gaps = 3/146 (2%) Frame = +1 Query: 79 IATELMDTDLHHIIRSNQE-LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNAN 255 +A E M +DL ++R Q L+ + +L LL+G+ + H+ N++HRDLKP+NLL++A+ Sbjct: 79 LAFEFMLSDLAEVVRHAQRPLAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS 138 Query: 256 CDLKICDFGLARPSSESD--MMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 LKI DFGLAR S + T V TRWYRAPELL + Y +D+W+VGCI EL+ Sbjct: 139 GQLKIADFGLARVFSPDGGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELL 198 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPT 507 N +PLFPG + + Q+ + ++GTP+ Sbjct: 199 NGSPLFPGENDIEQLCCVLRILGTPS 224
>CCRK_MOUSE (Q9JHU3) Cell cycle-related kinase (EC 2.7.11.22)| (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) Length = 346 Score = 134 bits (337), Expect = 2e-31 Identities = 65/146 (44%), Positives = 96/146 (65%), Gaps = 3/146 (2%) Frame = +1 Query: 79 IATELMDTDLHHIIRSNQE-LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNAN 255 +A E M +DL ++R Q L+ + +L LL+G+ + H+ N++HRDLKP+NLL++A+ Sbjct: 79 LAFEFMLSDLAEVVRHAQRPLAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISAS 138 Query: 256 CDLKICDFGLARPSSESD--MMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 LKI DFGLAR S + T V TRWYRAPELL + Y +D+W+VGCI EL+ Sbjct: 139 GQLKIADFGLARVFSPDGGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELL 198 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPT 507 N +PLFPG + + Q+ + ++GTP+ Sbjct: 199 NGSPLFPGENDIEQLCCVLRILGTPS 224
>CDC21_ORYSA (P29618) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 294 Score = 134 bits (336), Expect = 2e-31 Identities = 69/150 (46%), Positives = 95/150 (63%), Gaps = 4/150 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHC--QYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 +Y+ E +D DL + S E ++ + +LYQ+LRG+ Y HS V+HRDLKP NLL+ Sbjct: 76 IYLVFEYLDLDLKKFMDSCPEFAKNPTLIKSYLYQILRGVAYCHSHRVLHRDLKPQNLLI 135 Query: 247 NANCD-LKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 + + LK+ DFGLAR T VVT WYRAPE+LL S YS +D+WSVGCIF Sbjct: 136 DRRTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRQYSTPVDMWSVGCIFA 195 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 E++N+ PLFPG + ++ I V+GTP + Sbjct: 196 EMVNQKPLFPGDSEIDELFKIFRVLGTPNE 225
>CDC22_ORYSA (P29619) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 292 Score = 133 bits (335), Expect = 3e-31 Identities = 67/150 (44%), Positives = 95/150 (63%), Gaps = 3/150 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHC-QYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 +Y+ E +D DL + S+ + + FLYQ+LRG+ Y HS V+HRDLKP NLL++ Sbjct: 76 IYLVFEYLDLDLKKHMDSSPDFKNHRIVKSFLYQILRGIAYCHSHRVLHRDLKPQNLLID 135 Query: 250 ANCD-LKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 + LK+ DFGLAR T VVT WYRAPE+LL + YS +D+WSVGCIF E Sbjct: 136 RRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGARHYSTPVDMWSVGCIFAE 195 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 ++N+ PLFPG + ++ I ++GTP ++ Sbjct: 196 MVNQKPLFPGDSEIDELFKIFSIMGTPNEE 225
>CDC2_SCHPO (P04551) Cell division control protein 2 (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinse) Length = 297 Score = 133 bits (334), Expect = 3e-31 Identities = 68/153 (44%), Positives = 93/153 (60%), Gaps = 6/153 (3%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQE-----LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 +Y+ E +D DL + E L Q F YQL+ G+ + HS +IHRDLKP N Sbjct: 80 LYLVFEFLDMDLKKYMDRISETGATSLDPRLVQKFTYQLVNGVNFCHSRRIIHRDLKPQN 139 Query: 238 LLLNANCDLKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCI 414 LL++ +LK+ DFGLAR T +VT WYRAPE+LL S YS +D+WSVGCI Sbjct: 140 LLIDKEGNLKLADFGLARSFGVPLRNYTHEIVTLWYRAPEVLLGSRHYSTGVDIWSVGCI 199 Query: 415 FMELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 F E+I R+PLFPG + ++ I +V+GTP ++ Sbjct: 200 FAEMIRRSPLFPGDSEIDEIFKIFQVLGTPNEE 232
>CDC2_CHERU (P93101) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 133 bits (334), Expect = 3e-31 Identities = 69/151 (45%), Positives = 96/151 (63%), Gaps = 4/151 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEH--CQYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 +Y+ E +D DL + S + +++ + FLYQ+LRG+ Y HS V+HRDLKP NLL+ Sbjct: 76 LYLVFEYLDLDLKKHMDSCPDFAKDPRMIKRFLYQILRGIAYCHSHRVLHRDLKPQNLLI 135 Query: 247 NANCD-LKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 + + LK+ DFGLAR T VVT WYRAPE+LL S YS +DVWSVGCIF Sbjct: 136 DRQTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFA 195 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 E++N+ PLFPG + ++ I +GTP ++ Sbjct: 196 EMVNQKPLFPGDSEIDELFKIFRTLGTPNEE 226
>MDE3_SCHPO (O43077) Sporulation protein kinase mde3 (EC 2.7.11.1)| (Mei4-dependent protein 3) Length = 559 Score = 132 bits (333), Expect = 5e-31 Identities = 63/162 (38%), Positives = 101/162 (62%), Gaps = 10/162 (6%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHIIRSNQE--LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 + ++++ E MD +L + + Q ++E L Q++ G+++IH +HRD+KP N Sbjct: 96 YRNIFLVMEFMDCNLFQLFKRRQGRLFTKETAFNILLQIISGIEHIHKHGFMHRDIKPEN 155 Query: 238 LL--------LNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAID 393 +L +++ +K+ DFGLARPS SD +TEYV TRWYRAPELLL S Y+ ++D Sbjct: 156 ILVKRISPKPISSRYSIKLGDFGLARPSVSSDPLTEYVSTRWYRAPELLLRSGSYNHSVD 215 Query: 394 VWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 +++ GCI E+ + PLFPGR+ Q+ + E++G P D+L Sbjct: 216 LYAFGCIVFEIYSLKPLFPGRNETDQLNRVCEILGNPGIDEL 257
>PCTK3_RAT (O35832) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 132 bits (333), Expect = 5e-31 Identities = 66/144 (45%), Positives = 90/144 (62%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQELSEEH-CQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D+DL + L H + F++QLLRGL Y H ++HRDLKP NLL+N +L Sbjct: 197 EYLDSDLKQYLDHCGNLMNMHNVKIFMFQLLRGLAYCHRRKILHRDLKPQNLLINERGEL 256 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR S + + VVT WYR P++LL ST+YS ID+W VGCI E+ P Sbjct: 257 KLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKP 316 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG ++ LI ++GTPT++ Sbjct: 317 LFPGSTVKEELHLIFRLLGTPTEE 340
>PCTK3_MOUSE (Q04899) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 132 bits (333), Expect = 5e-31 Identities = 66/144 (45%), Positives = 90/144 (62%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQELSEEH-CQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D+DL + L H + F++QLLRGL Y H ++HRDLKP NLL+N +L Sbjct: 197 EYLDSDLKQYLDHCGNLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGEL 256 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR S + + VVT WYR P++LL ST+YS ID+W VGCI E+ P Sbjct: 257 KLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKP 316 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG ++ LI ++GTPT++ Sbjct: 317 LFPGSTVKEELHLIFRLLGTPTEE 340
>PCTK3_PONPY (Q5RD01) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 132 bits (333), Expect = 5e-31 Identities = 65/144 (45%), Positives = 92/144 (63%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDL-HHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D+DL ++ +S + + F++QLLRGL Y H ++HRDLKP NLL+N +L Sbjct: 218 EYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGEL 277 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR S + + VVT WYR P++LL ST+YS ID+W VGCI E+ P Sbjct: 278 KLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRP 337 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG ++ LI ++GTPT++ Sbjct: 338 LFPGSTVKEELHLIFRLLGTPTEE 361
>PCTK3_HUMAN (Q07002) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 132 bits (333), Expect = 5e-31 Identities = 65/144 (45%), Positives = 92/144 (63%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDL-HHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D+DL ++ +S + + F++QLLRGL Y H ++HRDLKP NLL+N +L Sbjct: 218 EYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGEL 277 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR S + + VVT WYR P++LL ST+YS ID+W VGCI E+ P Sbjct: 278 KLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRP 337 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG ++ LI ++GTPT++ Sbjct: 338 LFPGSTVKEELHLIFRLLGTPTEE 361
>CDC28_CANAL (P43063) Cell division control protein 28 (EC 2.7.11.22)| Length = 317 Score = 132 bits (333), Expect = 5e-31 Identities = 67/151 (44%), Positives = 93/151 (61%), Gaps = 4/151 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQE---LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 +Y+ E +D DL + S + L + F+ QL+RG+K+ HS V+HRDLKP NLL Sbjct: 81 LYLVFEFLDLDLKKYMESIPQGVGLGANMIKRFMNQLIRGIKHCHSHRVLHRDLKPQNLL 140 Query: 244 LNANCDLKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 ++ +LK+ DFGLAR T VVT WYRAPE+LL YS +D+WSVGCIF Sbjct: 141 IDKEGNLKLADFGLARAFGVPLRAYTHEVVTLWYRAPEILLGGKQYSTGVDMWSVGCIFA 200 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 E+ NR PLFPG + ++ I ++GTP ++ Sbjct: 201 EMCNRKPLFPGDSEIDEIFRIFRILGTPNEE 231
>ICK_HUMAN (Q9UPZ9) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2) Length = 632 Score = 132 bits (332), Expect = 6e-31 Identities = 68/149 (45%), Positives = 90/149 (60%), Gaps = 1/149 (0%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHC-QYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 +Y E M +L+ +I+ +L E + +YQ+L+GL +IH HRDLKP NLL Sbjct: 75 LYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCM 134 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 +KI DFGLAR T+YV TRWYRAPE+LL ST+YS+ IDVW+VGCI E+ Sbjct: 135 GPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVY 194 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 PLFPG + + I +V+GTP D Sbjct: 195 TLRPLFPGASEIDTIFKICQVLGTPKKTD 223
>CDK5_XENLA (P51166) Cell division protein kinase 5 (EC 2.7.11.22) (Neuronal| cyclin-dependent kinase 5) Length = 292 Score = 132 bits (332), Expect = 6e-31 Identities = 71/145 (48%), Positives = 92/145 (63%), Gaps = 3/145 (2%) Frame = +1 Query: 88 ELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E D DL S N +L E + F+YQLL+GL + HS NV+HRDLKP NLL+N N +L Sbjct: 81 EFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGEL 140 Query: 265 KICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRA- 438 K+ DFGLAR + VVT WYR P++L + YS +ID+WS GCIF EL N Sbjct: 141 KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR 200 Query: 439 PLFPGRDHMHQMRLITEVIGTPTDD 513 PLFPG D Q++ I ++GTPT++ Sbjct: 201 PLFPGNDVDDQLKRIFRLLGTPTEE 225
>MHK_ARATH (P43294) Serine/threonine-protein kinase MHK (EC 2.7.11.22)| Length = 443 Score = 132 bits (332), Expect = 6e-31 Identities = 69/152 (45%), Positives = 95/152 (62%), Gaps = 1/152 (0%) Frame = +1 Query: 52 IPQSFNDVYIATELMDTDLHHIIRSNQE-LSEEHCQYFLYQLLRGLKYIHSANVIHRDLK 228 I + N+++ E MD +L+HI++ + SE + F+ Q+L+GL ++H HRDLK Sbjct: 76 IVREHNELFFIFECMDHNLYHIMKERERPFSEGEIRSFMSQMLQGLAHMHKNGYFHRDLK 135 Query: 229 PSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVG 408 P NLL+ N LKI DFGLAR + TEYV TRWYRAPE+LL S+ Y+ A+D+W+VG Sbjct: 136 PENLLVTNNI-LKIADFGLAREVASMPPYTEYVSTRWYRAPEVLLQSSLYTPAVDMWAVG 194 Query: 409 CIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 I EL PLFPG + Q+ I V+G P Sbjct: 195 AILAELYALTPLFPGESEIDQLYKICCVLGKP 226
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 132 bits (332), Expect = 6e-31 Identities = 67/152 (44%), Positives = 94/152 (61%), Gaps = 4/152 (2%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQE---LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 N + + E MD DL + +N L + ++F+YQLLRG+ + H V+HRDLKP N Sbjct: 76 NKLNLVFEYMDKDLKKFMDTNGNKGALETKQVKWFMYQLLRGILFCHDNRVLHRDLKPQN 135 Query: 238 LLLNANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCI 414 LL+NA LK+ DFGLAR + + VVT WYRAP++LL S YS +ID+WS GCI Sbjct: 136 LLINAKGQLKLADFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYSTSIDIWSAGCI 195 Query: 415 FMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 E+ PLFPG + Q++ I +++GTP + Sbjct: 196 MAEMFTGRPLFPGSSNDDQLQHIFKLMGTPNE 227
>CDC21_MEDSA (P24923) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (Fragment) Length = 291 Score = 132 bits (332), Expect = 6e-31 Identities = 71/151 (47%), Positives = 94/151 (62%), Gaps = 4/151 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHCQY--FLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 +Y+ E +D DL + S+ E ++ Q FLYQ+L G+ Y HS V+HRDLKP NLL+ Sbjct: 73 LYLVFEYLDLDLKKHMDSSPEFIKDPRQVKMFLYQMLCGIAYCHSHRVLHRDLKPQNLLI 132 Query: 247 NANCD-LKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 + + LK+ DFGLAR T VVT WYRAPE+LL S YS +DVWSVGCIF Sbjct: 133 DRRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFA 192 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 E+ NR PL PG + ++ I ++GTP +D Sbjct: 193 EMANRRPLSPGDSEIDELFKIFRILGTPNED 223
>CDK5_BOVIN (Q02399) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Proline-directed protein kinase 33 kDa subunit) (PDPK) Length = 292 Score = 132 bits (331), Expect = 8e-31 Identities = 71/145 (48%), Positives = 93/145 (64%), Gaps = 3/145 (2%) Frame = +1 Query: 88 ELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E D DL S N +L E + FL+QLL+GL + HS NV+HRDLKP NLL+N N +L Sbjct: 81 EFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGEL 140 Query: 265 KICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRA- 438 K+ DFGLAR + VVT WYR+P++L + YS +ID+WS GCIF EL N Sbjct: 141 KLADFGLARAFGIPVRCYSAEVVTLWYRSPDVLFGAKLYSTSIDMWSAGCIFAELANAGR 200 Query: 439 PLFPGRDHMHQMRLITEVIGTPTDD 513 PLFPG D Q++ I ++GTPT++ Sbjct: 201 PLFPGNDVDDQLKRIFRLLGTPTEE 225
>AL2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22)| (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) Length = 384 Score = 132 bits (331), Expect = 8e-31 Identities = 68/145 (46%), Positives = 94/145 (64%), Gaps = 3/145 (2%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQE-LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E M TDL + + L + + F++QLLRGL YIH +V+HRDLKP NLL++ +L Sbjct: 128 EYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGEL 187 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR S S + VVT WYR P+ LL +T+YS+ +D+W GCIF+E+ P Sbjct: 188 KLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQP 247 Query: 442 LFPGRDH-MHQMRLITEVIGTPTDD 513 LFPG + + Q+ I EV+G PT+D Sbjct: 248 LFPGVSNILEQLEKIWEVLGVPTED 272
>CDK7_XENLA (P20911) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (40 kDa protein kinase) (P40 MO15) (CDC2/CDK2,4-activating kinase) Length = 352 Score = 132 bits (331), Expect = 8e-31 Identities = 64/151 (42%), Positives = 97/151 (64%), Gaps = 2/151 (1%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 +++ + + M+TDL II+ L+ H + ++ L+GL+Y+H ++HRDLKP+NLL Sbjct: 91 SNISLVFDFMETDLEVIIKDTSLVLTPAHIKSYMLMTLQGLEYLHHLWILHRDLKPNNLL 150 Query: 244 LNANCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 L+ N LK+ DFGLA+ S + + T VVTRWYR+PELL + Y +D+W+VGCI Sbjct: 151 LDENGVLKLADFGLAKSFGSPNRIYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILA 210 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 EL+ R P PG + Q+ I E +GTPT++ Sbjct: 211 ELLLRVPFLPGDSDLDQLTRIFETLGTPTEE 241
>ICK_RAT (Q62726) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (MAK-related kinase) (MRK) Length = 629 Score = 132 bits (331), Expect = 8e-31 Identities = 68/149 (45%), Positives = 90/149 (60%), Gaps = 1/149 (0%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHC-QYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 +Y E M +L+ +I+ +L E + +YQ+L+GL +IH HRDLKP NLL Sbjct: 75 LYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCM 134 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 +KI DFGLAR T+YV TRWYRAPE+LL ST+YS+ IDVW+VGCI E+ Sbjct: 135 GPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVY 194 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 PLFPG + + I +V+GTP D Sbjct: 195 TLRPLFPGASEIDTIFKICQVLGTPKKTD 223
>PCTK2_RAT (O35831) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 131 bits (330), Expect = 1e-30 Identities = 66/144 (45%), Positives = 90/144 (62%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQELSEEH-CQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL + + H + FLYQ+LRGL Y H V+HRDLKP NLL+N +L Sbjct: 268 EYLDKDLKQYMDDCGSIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGEL 327 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR S + + VVT WYR P++LL S++YS ID+W VGCIF E+ + P Sbjct: 328 KLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRP 387 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG ++ LI ++GTP+ + Sbjct: 388 LFPGSTVEDELHLIFRLLGTPSQE 411
>PCTK2_MOUSE (Q8K0D0) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 131 bits (330), Expect = 1e-30 Identities = 66/144 (45%), Positives = 90/144 (62%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQELSEEH-CQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL + + H + FLYQ+LRGL Y H V+HRDLKP NLL+N +L Sbjct: 268 EYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGEL 327 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR S + + VVT WYR P++LL S++YS ID+W VGCIF E+ + P Sbjct: 328 KLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRP 387 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG ++ LI ++GTP+ + Sbjct: 388 LFPGSTVEDELHLIFRLLGTPSQE 411
>PCTK2_HUMAN (Q00537) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 131 bits (330), Expect = 1e-30 Identities = 66/144 (45%), Positives = 90/144 (62%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQELSEEH-CQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL + + H + FLYQ+LRGL Y H V+HRDLKP NLL+N +L Sbjct: 268 EYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGEL 327 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR S + + VVT WYR P++LL S++YS ID+W VGCIF E+ + P Sbjct: 328 KLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRP 387 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG ++ LI ++GTP+ + Sbjct: 388 LFPGSTVEDELHLIFRLLGTPSQE 411
>ICK_MOUSE (Q9JKV2) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK) Length = 629 Score = 131 bits (330), Expect = 1e-30 Identities = 67/149 (44%), Positives = 90/149 (60%), Gaps = 1/149 (0%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHC-QYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 +Y E M +L+ +I+ +L E + +YQ+L+GL +IH HRDLKP NLL Sbjct: 75 LYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCM 134 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 +KI DFGLAR T+YV TRWYRAPE+LL ST+YS+ ID+W+VGCI E+ Sbjct: 135 GPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEVY 194 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 PLFPG + + I +V+GTP D Sbjct: 195 TLRPLFPGASEIDTIFKICQVLGTPKKTD 223
>CDC2_MAIZE (P23111) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 131 bits (330), Expect = 1e-30 Identities = 67/150 (44%), Positives = 94/150 (62%), Gaps = 4/150 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHC--QYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 +Y+ E +D DL + S E ++ + +LYQ+L G+ Y HS V+HRDLKP NLL+ Sbjct: 76 IYLVFEYLDLDLKKFMDSCPEFAKNPTLIKSYLYQILHGVAYCHSHRVLHRDLKPQNLLI 135 Query: 247 NANCD-LKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 + + LK+ DFGLAR T VVT WYRAPE+LL + YS +DVWSVGCIF Sbjct: 136 DRRTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGARQYSTPVDVWSVGCIFA 195 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 E++N+ PLFPG + ++ I ++GTP + Sbjct: 196 EMVNQKPLFPGDSEIDELFKIFRILGTPNE 225
>CDK5_MOUSE (P49615) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6) Length = 292 Score = 131 bits (329), Expect = 1e-30 Identities = 71/145 (48%), Positives = 92/145 (63%), Gaps = 3/145 (2%) Frame = +1 Query: 88 ELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E D DL S N +L E + FL+QLL+GL + HS NV+HRDLKP NLL+N N +L Sbjct: 81 EFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGEL 140 Query: 265 KICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRA- 438 K+ DFGLAR + VVT WYR P++L + YS +ID+WS GCIF EL N Sbjct: 141 KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR 200 Query: 439 PLFPGRDHMHQMRLITEVIGTPTDD 513 PLFPG D Q++ I ++GTPT++ Sbjct: 201 PLFPGNDVDDQLKRIFRLLGTPTEE 225
>CDK5_HUMAN (Q00535) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 131 bits (329), Expect = 1e-30 Identities = 71/145 (48%), Positives = 92/145 (63%), Gaps = 3/145 (2%) Frame = +1 Query: 88 ELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E D DL S N +L E + FL+QLL+GL + HS NV+HRDLKP NLL+N N +L Sbjct: 81 EFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGEL 140 Query: 265 KICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRA- 438 K+ DFGLAR + VVT WYR P++L + YS +ID+WS GCIF EL N Sbjct: 141 KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR 200 Query: 439 PLFPGRDHMHQMRLITEVIGTPTDD 513 PLFPG D Q++ I ++GTPT++ Sbjct: 201 PLFPGNDVDDQLKRIFRLLGTPTEE 225
>BUR1_YARLI (Q6C842) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 706 Score = 130 bits (328), Expect = 2e-30 Identities = 65/161 (40%), Positives = 98/161 (60%), Gaps = 12/161 (7%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 VY+ T MD DL ++ + +LS H + ++ QLL G+ Y+H+ +HRD+K +N+L+N Sbjct: 118 VYMVTPYMDHDLAGLLGNQSVQLSPAHIKCYMLQLLEGIGYLHAKKFLHRDIKAANILVN 177 Query: 250 ANCDLKICDFGLAR------PSSES-----DMMTEYVVTRWYRAPELLLNSTDYSAAIDV 396 LK+ DFGLAR P+S++ + +T VVTRWYR PEL+L Y+ AID+ Sbjct: 178 DQGILKLADFGLARGYDGPAPNSQTAGVNTENLTAMVVTRWYRPPELILGDRKYTTAIDM 237 Query: 397 WSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 W +GC+F E R P+FPG + Q I + +G PT+D + Sbjct: 238 WGIGCVFGEFFTRKPIFPGASDVDQGSKIFQAVGVPTEDTM 278
>CDC2H_PLABA (Q4Z6R1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 130 bits (328), Expect = 2e-30 Identities = 68/145 (46%), Positives = 88/145 (60%), Gaps = 2/145 (1%) Frame = +1 Query: 88 ELMDTDLHHIIR-SNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL +I + L + FL QLL G+ Y H V+HRDLKP NLL+N +L Sbjct: 80 EHLDQDLKKLIDVCDGGLESVTAKSFLLQLLNGIAYCHEHRVLHRDLKPQNLLINREGEL 139 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 KI DFGLAR + T VVT WYRAP++L+ S YS ID+WSVGCIF E++N P Sbjct: 140 KIADFGLARAFGIPARRYTHEVVTLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRP 199 Query: 442 LFPGRDHMHQMRLITEVIGTPTDDD 516 LFPG Q+ I +++GTP + Sbjct: 200 LFPGASETDQLMRIFKILGTPNSQN 224
>CDK2_ENTHI (Q04770) Cell division protein kinase 2 homolog (EC 2.7.11.22)| Length = 291 Score = 130 bits (327), Expect = 2e-30 Identities = 63/148 (42%), Positives = 94/148 (63%), Gaps = 1/148 (0%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNA 252 +Y+ E D DL+ + + ++ + +YQ+L+GL + H ++HRD+KP N+L+N Sbjct: 76 LYLVFEFCDEDLYQFMSRSSKIPINETRSIVYQILQGLAFCHYHQILHRDMKPQNILINK 135 Query: 253 NCDLKICDFGLARPSSESDMM-TEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 N +K+ +FGLAR ++ +D T VVT WYRAPE+LL +T Y AID+WS IF ELI Sbjct: 136 NGTIKLGEFGLARLTTINDRKYTSEVVTLWYRAPEILLGATQYGGAIDIWSTAAIFGELI 195 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDD 513 N+ LF GR + Q+ I +GTPT+D Sbjct: 196 NKEELFKGRCKIDQLFKIFSQLGTPTED 223
>PFTK1_MOUSE (O35495) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 130 bits (326), Expect = 3e-30 Identities = 68/145 (46%), Positives = 93/145 (64%), Gaps = 3/145 (2%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQE-LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E + TDL + + L ++ + FL+QLLRGL YIH ++HRDLKP NLL++ +L Sbjct: 211 EYVHTDLCQYMEQHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGEL 270 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR S S + VVT WYR P++LL ST+YS +D+W VGCIF+E+I Sbjct: 271 KLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVA 330 Query: 442 LFPG-RDHMHQMRLITEVIGTPTDD 513 FPG +D Q+ I V+GTP +D Sbjct: 331 AFPGMKDIQDQLERIFLVLGTPNED 355
>PFTK1_HUMAN (O94921) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 130 bits (326), Expect = 3e-30 Identities = 68/145 (46%), Positives = 94/145 (64%), Gaps = 3/145 (2%) Frame = +1 Query: 88 ELMDTDL-HHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E + TDL ++ + L ++ + FL+QLLRGL YIH ++HRDLKP NLL++ +L Sbjct: 211 EYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGEL 270 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR S S + VVT WYR P++LL ST+YS +D+W VGCIF+E+I Sbjct: 271 KLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVA 330 Query: 442 LFPG-RDHMHQMRLITEVIGTPTDD 513 FPG +D Q+ I V+GTP +D Sbjct: 331 AFPGMKDIQDQLERIFLVLGTPNED 355
>PIT1_SCHPO (O14132) Sporulation protein kinase pit1 (EC 2.7.11.1)| Length = 650 Score = 130 bits (326), Expect = 3e-30 Identities = 63/156 (40%), Positives = 96/156 (61%), Gaps = 7/156 (4%) Frame = +1 Query: 64 FNDVYIATELMDTDLHHII--RSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 F ++I E +D +L+ +I R N L+ E Q + Q+ +GL +IH+ HRD+KP N Sbjct: 107 FRCLHIVMEFLDCNLYQLISTRKNDPLTLEQVQDIMRQIFKGLNHIHTNGFFHRDMKPEN 166 Query: 238 LLLNANCD-----LKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 +L+++N D +KI DFGLAR + TEYV TRWYRAPELLL + YS +D+++ Sbjct: 167 ILISSNSDSSSFNVKIADFGLAREINSRPPYTEYVSTRWYRAPELLLRDSYYSFPVDIYA 226 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 GC+ E+ P+FPG D Q+ + E++G+P + Sbjct: 227 AGCMAFEIATLQPIFPGNDDFDQLYKMCEILGSPDE 262
>CRK1_SCHPO (Q12126) Serine/threonine-protein kinase crk1 (EC 2.7.11.23)| (Mitotic catastrophe suppressor 6) Length = 335 Score = 130 bits (326), Expect = 3e-30 Identities = 61/147 (41%), Positives = 93/147 (63%), Gaps = 1/147 (0%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQELSEE-HCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 +++ I E +D+DL +I+ + + H + ++ LLRGL +IHS ++HRDLKP+NLL Sbjct: 81 SNLNIILEFLDSDLEMLIKDKFIVFQPAHIKSWMVMLLRGLHHIHSRFILHRDLKPNNLL 140 Query: 244 LNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 ++++ LK+ DFGL+R M+ V+TRWYR PEL + Y +D+WSVGCIF E Sbjct: 141 ISSDGVLKLADFGLSRDFGTPSHMSHQVITRWYRPPELFMGCRSYGTGVDMWSVGCIFAE 200 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTP 504 L+ R P PG + Q+ +I +GTP Sbjct: 201 LMLRTPYLPGESDLDQLNVIFRALGTP 227
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 130 bits (326), Expect = 3e-30 Identities = 68/151 (45%), Positives = 93/151 (61%), Gaps = 3/151 (1%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQE--LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNL 240 N +Y+ E + DL + S+ +S + +L+QLL+GL + HS V+HRDLKP NL Sbjct: 74 NKLYLVFEFLHQDLKRFMDSSTVTGISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 241 LLNANCDLKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L+NA ++K+ DFGLAR T VVT WYRAPE+LL YS A+D+WS+GCIF Sbjct: 134 LINAQGEIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIF 193 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 E+I R LFPG + Q+ I +GTP + Sbjct: 194 AEMITRKALFPGDSEIDQLFRIFRTLGTPDE 224
>CDC2H_PLAYO (Q7RM49) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 289 Score = 130 bits (326), Expect = 3e-30 Identities = 68/145 (46%), Positives = 88/145 (60%), Gaps = 2/145 (1%) Frame = +1 Query: 88 ELMDTDLHHIIR-SNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL +I + L + FL QLL G+ Y H V+HRDLKP NLL+N +L Sbjct: 81 EHLDQDLKKLIDVCDGGLESVTAKSFLLQLLNGIAYCHEHRVLHRDLKPQNLLINREGEL 140 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 KI DFGLAR + T VVT WYRAP++L+ S YS ID+WSVGCIF E++N P Sbjct: 141 KIADFGLARAFGIPARRYTHEVVTLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRP 200 Query: 442 LFPGRDHMHQMRLITEVIGTPTDDD 516 LFPG Q+ I +++GTP + Sbjct: 201 LFPGVSETDQLMRIFKILGTPNSQN 225
>CTK1_YEAST (Q03957) CTD kinase subunit alpha (EC 2.7.11.23) (CTD kinase 58 kDa| subunit) (CTDK-I alpha subunit) Length = 528 Score = 130 bits (326), Expect = 3e-30 Identities = 59/151 (39%), Positives = 95/151 (62%), Gaps = 1/151 (0%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPS 234 +S VY+ E D DL ++ + + ++S C++ QLL G++Y+H ++HRD+K S Sbjct: 251 ESQKTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGS 310 Query: 235 NLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCI 414 N+L++ +LKI DFGLAR + T V+T WYR PELLL +T+Y +D+W GC+ Sbjct: 311 NILIDNQGNLKITDFGLARKMNSRADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCL 370 Query: 415 FMELINRAPLFPGRDHMHQMRLITEVIGTPT 507 +EL N+ +F G + + Q+ I +++GTPT Sbjct: 371 LVELFNKTAIFQGSNELEQIESIFKIMGTPT 401
>CDK3_HUMAN (Q00526) Cell division protein kinase 3 (EC 2.7.11.22)| Length = 305 Score = 129 bits (325), Expect = 4e-30 Identities = 67/150 (44%), Positives = 93/150 (62%), Gaps = 3/150 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSN--QELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 +Y+ E + DL + S EL + +L+QLL+G+ + HS VIHRDLKP NLL+ Sbjct: 76 LYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLI 135 Query: 247 NANCDLKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 N +K+ DFGLAR T VVT WYRAPE+LL S Y+ A+D+WS+GCIF E Sbjct: 136 NELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAE 195 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 ++ R LFPG + Q+ I ++GTP++D Sbjct: 196 MVTRKALFPGDSEIDQLFRIFRMLGTPSED 225
>CDC2H_PLACH (Q4Y4B1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 129 bits (325), Expect = 4e-30 Identities = 68/145 (46%), Positives = 88/145 (60%), Gaps = 2/145 (1%) Frame = +1 Query: 88 ELMDTDLHHIIR-SNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL +I + L + FL QLL G+ Y H V+HRDLKP NLL+N +L Sbjct: 80 EHLDQDLKKLIDVCDGGLESVTAKSFLLQLLNGIAYCHEHRVLHRDLKPQNLLINREGEL 139 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 KI DFGLAR + T VVT WYRAP++L+ S YS ID+WSVGCIF E++N P Sbjct: 140 KIADFGLARAFGIPARRYTHEVVTLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRP 199 Query: 442 LFPGRDHMHQMRLITEVIGTPTDDD 516 LFPG Q+ I +++GTP + Sbjct: 200 LFPGVSDTDQLMRIFKILGTPNSQN 224
>CD2L7_HUMAN (Q9NYV4) Cell division cycle 2-related protein kinase 7 (EC| 2.7.11.22) (CDC2-related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) Length = 1490 Score = 129 bits (324), Expect = 5e-30 Identities = 67/146 (45%), Positives = 90/146 (61%), Gaps = 3/146 (2%) Frame = +1 Query: 76 YIATELMDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNA 252 Y+ E MD DL ++ S SE+H + F+ QL+ GL+Y H N +HRD+K SN+LLN Sbjct: 810 YLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNN 869 Query: 253 NCDLKICDFGLAR--PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMEL 426 + +K+ DFGLAR S ES T V+T WYR PELLL Y+ AIDVWS GCI EL Sbjct: 870 SGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGEL 929 Query: 427 INRAPLFPGRDHMHQMRLITEVIGTP 504 + P+F + Q+ LI+ + G+P Sbjct: 930 FTKKPIFQANLELAQLELISRLCGSP 955
>CD2L5_HUMAN (Q14004) Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22)| (CDC2-related protein kinase 5) (Cholinesterase-related cell division controller) Length = 1512 Score = 129 bits (323), Expect = 7e-30 Identities = 66/146 (45%), Positives = 87/146 (59%), Gaps = 3/146 (2%) Frame = +1 Query: 76 YIATELMDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNA 252 Y+ E MD DL ++ S +E H + F+ QL+ GL Y H N +HRD+K SN+LLN Sbjct: 788 YLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNN 847 Query: 253 NCDLKICDFGLAR--PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMEL 426 +K+ DFGLAR S ES T V+T WYR PELLL Y+ AIDVWS GCI EL Sbjct: 848 RGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGEL 907 Query: 427 INRAPLFPGRDHMHQMRLITEVIGTP 504 + P+F + Q+ LI+ + G+P Sbjct: 908 FTKKPIFQANQELAQLELISRICGSP 933
>CDK5_RAT (Q03114) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 129 bits (323), Expect = 7e-30 Identities = 70/145 (48%), Positives = 91/145 (62%), Gaps = 3/145 (2%) Frame = +1 Query: 88 ELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E D DL S N +L E + L+QLL+GL + HS NV+HRDLKP NLL+N N +L Sbjct: 81 EFCDQDLKKYFDSCNGDLDPEIVKSLLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGEL 140 Query: 265 KICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRA- 438 K+ DFGLAR + VVT WYR P++L + YS +ID+WS GCIF EL N Sbjct: 141 KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR 200 Query: 439 PLFPGRDHMHQMRLITEVIGTPTDD 513 PLFPG D Q++ I ++GTPT++ Sbjct: 201 PLFPGNDVDDQLKRIFRLLGTPTEE 225
>CD2L5_MOUSE (Q69ZA1) Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22)| (CDC2-related protein kinase 5) Length = 1511 Score = 129 bits (323), Expect = 7e-30 Identities = 66/146 (45%), Positives = 87/146 (59%), Gaps = 3/146 (2%) Frame = +1 Query: 76 YIATELMDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNA 252 Y+ E MD DL ++ S +E H + F+ QL+ GL Y H N +HRD+K SN+LLN Sbjct: 788 YLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNN 847 Query: 253 NCDLKICDFGLAR--PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMEL 426 +K+ DFGLAR S ES T V+T WYR PELLL Y+ AIDVWS GCI EL Sbjct: 848 RGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGEL 907 Query: 427 INRAPLFPGRDHMHQMRLITEVIGTP 504 + P+F + Q+ LI+ + G+P Sbjct: 908 FTKKPIFQANQELAQLELISRICGSP 933
>CDC28_YEAST (P00546) Cell division control protein 28 (EC 2.7.11.22)| Length = 298 Score = 129 bits (323), Expect = 7e-30 Identities = 65/150 (43%), Positives = 90/150 (60%), Gaps = 4/150 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHI---IRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 +Y+ E +D DL I +Q L + + F+ QL +G+ Y HS ++HRDLKP NLL Sbjct: 84 LYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLL 143 Query: 244 LNANCDLKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 +N + +LK+ DFGLAR T +VT WYRAPE+LL YS +D WS+GCIF Sbjct: 144 INKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFA 203 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 E+ NR P+F G + Q+ I V+GTP + Sbjct: 204 EMCNRKPIFSGDSEIDQIFKIFRVLGTPNE 233
>CD2L2_HUMAN (Q9UQ88) PITSLRE serine/threonine-protein kinase CDC2L2 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11) Length = 780 Score = 129 bits (323), Expect = 7e-30 Identities = 66/155 (42%), Positives = 98/155 (63%), Gaps = 2/155 (1%) Frame = +1 Query: 52 IPQSFNDVYIATELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLK 228 + + + +YI ++ DL ++ + Q + + QLLRG+K++H ++HRDLK Sbjct: 490 VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLK 549 Query: 229 PSNLLLNANCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 SNLLL+ LK+ DFGLAR S T VVT+WYRAPELLL + +YS A+D+WSV Sbjct: 550 TSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSV 609 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 GCIF EL+ + PLFPG + Q+ + + +GTP++ Sbjct: 610 GCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSE 644
>GSK3B_MOUSE (Q9WV60) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 128 bits (322), Expect = 9e-30 Identities = 60/137 (43%), Positives = 89/137 (64%), Gaps = 1/137 (0%) Frame = +1 Query: 112 HIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCD-LKICDFGLA 288 H R+ Q L + + ++YQL R L YIHS + HRD+KP NLLL+ + LK+CDFG A Sbjct: 145 HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA 204 Query: 289 RPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMH 468 + + Y+ +R+YRAPEL+ +TDY+++IDVWS GC+ EL+ P+FPG + Sbjct: 205 KQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVD 264 Query: 469 QMRLITEVIGTPTDDDL 519 Q+ I +V+GTPT + + Sbjct: 265 QLVEIIKVLGTPTREQI 281
>GSK3B_HUMAN (P49841) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 128 bits (322), Expect = 9e-30 Identities = 60/137 (43%), Positives = 89/137 (64%), Gaps = 1/137 (0%) Frame = +1 Query: 112 HIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCD-LKICDFGLA 288 H R+ Q L + + ++YQL R L YIHS + HRD+KP NLLL+ + LK+CDFG A Sbjct: 145 HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA 204 Query: 289 RPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMH 468 + + Y+ +R+YRAPEL+ +TDY+++IDVWS GC+ EL+ P+FPG + Sbjct: 205 KQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVD 264 Query: 469 QMRLITEVIGTPTDDDL 519 Q+ I +V+GTPT + + Sbjct: 265 QLVEIIKVLGTPTREQI 281
>CD2L1_HUMAN (P21127) PITSLRE serine/threonine-protein kinase CDC2L1 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1) Length = 795 Score = 128 bits (321), Expect = 1e-29 Identities = 66/155 (42%), Positives = 98/155 (63%), Gaps = 2/155 (1%) Frame = +1 Query: 52 IPQSFNDVYIATELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLK 228 + + + +YI ++ DL ++ + Q + + QLLRG+K++H ++HRDLK Sbjct: 505 VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLK 564 Query: 229 PSNLLLNANCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 SNLLL+ LK+ DFGLAR S T VVT WYRAPELLL + +YS A+D+WSV Sbjct: 565 TSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSV 624 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 GCIF EL+ + PLFPG+ + Q+ + + +GTP++ Sbjct: 625 GCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSE 659
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 128 bits (321), Expect = 1e-29 Identities = 66/155 (42%), Positives = 93/155 (60%), Gaps = 7/155 (4%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSN------QELSEEHCQYFLYQLLRGLKYIHSANVIHRDLK 228 N + + E MD DL + S + L +YF +QLL+GL + H ++HRDLK Sbjct: 76 NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLK 135 Query: 229 PSNLLLNANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 P NLL+N LK+ DFGLAR + + VVT WYRAP++L+ S YS +ID+WS Sbjct: 136 PQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSC 195 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 GCI E+I PLFPG + Q++LI +++GTP + Sbjct: 196 GCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE 230
>BUR1_NEUCR (Q871M9) Serine/threonine-protein kinase bur-1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 545 Score = 128 bits (321), Expect = 1e-29 Identities = 65/163 (39%), Positives = 100/163 (61%), Gaps = 14/163 (8%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 VY+ T MD DL ++ + + +E + +L QLL GLKY+H+ +++HRD+K +NLL+N Sbjct: 107 VYMVTPYMDHDLSGLLDNPSVRFTEPQVKCYLLQLLEGLKYLHANHILHRDMKAANLLIN 166 Query: 250 ANCDLKICDFGLARPSSESDM-------------MTEYVVTRWYRAPELLLNSTDYSAAI 390 L+I DFGLAR E D+ T VVTRWYR PELL++ Y+ AI Sbjct: 167 NKGVLQIADFGLAR-HYEGDIPQPGKGSGEGKRDYTSLVVTRWYRPPELLMHLKRYTTAI 225 Query: 391 DVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 D+W VGC+F E++ P+ G +HQ+ L+ ++ GTP+++ + Sbjct: 226 DMWGVGCVFAEMLEGKPVLQGESDLHQLELVWDLCGTPSEETM 268
>KIN28_YEAST (P06242) Serine/threonine-protein kinase KIN28 (EC 2.7.11.23)| Length = 306 Score = 127 bits (320), Expect = 1e-29 Identities = 63/154 (40%), Positives = 99/154 (64%), Gaps = 2/154 (1%) Frame = +1 Query: 61 SFNDVYIATELMDTDLHHIIRSNQEL-SEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 +++++ + E + TDL +I+ L + + ++ LRG+ + H ++HRDLKP+N Sbjct: 75 AYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNN 134 Query: 238 LLLNANCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCI 414 LL + + +K+ DFGLAR + +++T VVTRWYRAPELL + Y++AID+WSVG I Sbjct: 135 LLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVI 194 Query: 415 FMELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 F EL+ R P PG++ + QM + +GTPTD D Sbjct: 195 FAELMLRIPYLPGQNDVDQMEVTFRALGTPTDRD 228
>CDC2H_PLAFK (Q07785) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (PfPK5) Length = 288 Score = 127 bits (320), Expect = 1e-29 Identities = 67/141 (47%), Positives = 85/141 (60%), Gaps = 2/141 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQE-LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL ++ + L + FL QLL G+ Y H V+HRDLKP NLL+N +L Sbjct: 80 EHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGEL 139 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 KI DFGLAR T VVT WYRAP++L+ S YS ID+WSVGCIF E++N P Sbjct: 140 KIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTP 199 Query: 442 LFPGRDHMHQMRLITEVIGTP 504 LFPG Q+ I ++GTP Sbjct: 200 LFPGVSEADQLMRIFRILGTP 220
>CDC2H_PLAF7 (P61075) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 127 bits (320), Expect = 1e-29 Identities = 67/141 (47%), Positives = 85/141 (60%), Gaps = 2/141 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQE-LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL ++ + L + FL QLL G+ Y H V+HRDLKP NLL+N +L Sbjct: 80 EHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGEL 139 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 KI DFGLAR T VVT WYRAP++L+ S YS ID+WSVGCIF E++N P Sbjct: 140 KIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTP 199 Query: 442 LFPGRDHMHQMRLITEVIGTP 504 LFPG Q+ I ++GTP Sbjct: 200 LFPGVSEADQLMRIFRILGTP 220
>GSK3B_RAT (P18266) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) (Factor A) (FA) Length = 420 Score = 127 bits (319), Expect = 2e-29 Identities = 59/137 (43%), Positives = 89/137 (64%), Gaps = 1/137 (0%) Frame = +1 Query: 112 HIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCD-LKICDFGLA 288 H R+ Q L + + ++YQL R L YIHS + HRD+KP NLLL+ + LK+CDFG A Sbjct: 145 HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA 204 Query: 289 RPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMH 468 + + Y+ +R+YRAPEL+ +TDY+++ID+WS GC+ EL+ P+FPG + Sbjct: 205 KQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDMWSAGCVLAELLLGQPIFPGDSGVD 264 Query: 469 QMRLITEVIGTPTDDDL 519 Q+ I +V+GTPT + + Sbjct: 265 QLVEIIKVLGTPTREQI 281
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 127 bits (319), Expect = 2e-29 Identities = 66/151 (43%), Positives = 93/151 (61%), Gaps = 3/151 (1%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQ--ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNL 240 N +Y+ E ++ DL + + +S + +L+QLL+GL + HS V+HRDLKP NL Sbjct: 74 NKLYLVFEFLNQDLKKFMDGSNISGISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 241 LLNANCDLKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L+N++ +K+ DFGLAR T VVT WYRAPE+LL YS A+D+WS+GCIF Sbjct: 134 LINSDGAIKLADFGLARAFGVPVRTFTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIF 193 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 E+I R LFPG + Q+ I +GTP + Sbjct: 194 AEMITRRALFPGDSEIDQLFRIFRTLGTPDE 224
>CDKL4_MOUSE (Q3TZA2) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 342 Score = 127 bits (319), Expect = 2e-29 Identities = 59/133 (44%), Positives = 85/133 (63%) Frame = +1 Query: 100 TDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDF 279 T L+ + R+ +S+ + L+Q L+ L + H N IHRD+KP N+L+ +KICDF Sbjct: 86 TLLNELERNPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDF 145 Query: 280 GLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRD 459 G AR D T+YV TRWYRAPELL+ T Y +++DVW+VGC+F EL+ PL+PG+ Sbjct: 146 GFARILIPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKS 205 Query: 460 HMHQMRLITEVIG 498 + Q+ LI +G Sbjct: 206 DVDQLYLIIRTLG 218
>CDC2H_PLAVI (Q9XZD6) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (Pvcrk2) Length = 288 Score = 127 bits (319), Expect = 2e-29 Identities = 67/145 (46%), Positives = 87/145 (60%), Gaps = 2/145 (1%) Frame = +1 Query: 88 ELMDTDLHHIIR-SNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL ++ + L + FL QLL G+ Y H V+HRDLKP NLL+N +L Sbjct: 80 EHLDQDLKKLLDVCDGGLESVTAKSFLLQLLSGIAYCHEHRVLHRDLKPQNLLINREGEL 139 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 KI DFGLAR T VVT WYRAP++L+ S YS ID+WSVGCIF E++N P Sbjct: 140 KIADFGLARAFGIPVRKYTHEVVTLWYRAPDILMGSKKYSTPIDMWSVGCIFAEMVNGRP 199 Query: 442 LFPGRDHMHQMRLITEVIGTPTDDD 516 LFPG Q+ I ++GTP ++ Sbjct: 200 LFPGVSETDQLMRIFRILGTPNSEN 224
>CDK2_MESAU (P48963) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 127 bits (318), Expect = 2e-29 Identities = 66/151 (43%), Positives = 92/151 (60%), Gaps = 3/151 (1%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQE--LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNL 240 N +Y+ EL+ DL + ++ + + +L+QLL+GL + HS V+HRDLKP NL Sbjct: 74 NKLYLVFELLHQDLKKFMDASAVTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 241 LLNANCDLKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L+NA +K+ DFGLAR T VVT WYRAPE+LL YS A+D+WS+GCIF Sbjct: 134 LINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIF 193 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 E++ R LFPG + Q+ I +GTP + Sbjct: 194 AEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224
>KSG7_ARATH (Q39011) Shaggy-related protein kinase eta (EC 2.7.11.1) (ASK-eta)| (BRASSINOSTEROID-INSENSITIVE 2) (ULTRACURVATA1) Length = 380 Score = 127 bits (318), Expect = 2e-29 Identities = 60/140 (42%), Positives = 93/140 (66%), Gaps = 2/140 (1%) Frame = +1 Query: 106 LHHIIRSNQELSEEHCQYFLYQLLRGLKYIHS-ANVIHRDLKPSNLLLNA-NCDLKICDF 279 L H +NQ + + + ++YQ+ RGL YIH+ A V HRDLKP NLL++ +KICDF Sbjct: 126 LKHYSSANQRMPLVYVKLYMYQIFRGLAYIHNVAGVCHRDLKPQNLLVDPLTHQVKICDF 185 Query: 280 GLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRD 459 G A+ + + Y+ +R+YRAPEL+ +T+Y+ +ID+WS GC+ EL+ PLFPG + Sbjct: 186 GSAKQLVKGEANISYICSRFYRAPELIFGATEYTTSIDIWSAGCVLAELLLGQPLFPGEN 245 Query: 460 HMHQMRLITEVIGTPTDDDL 519 + Q+ I +V+GTPT +++ Sbjct: 246 AVDQLVEIIKVLGTPTREEI 265
>CDC2H_PLAKH (O96821) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 127 bits (318), Expect = 2e-29 Identities = 67/141 (47%), Positives = 85/141 (60%), Gaps = 2/141 (1%) Frame = +1 Query: 88 ELMDTDLHHIIR-SNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL ++ + L + FL QLL G+ Y H V+HRDLKP NLL+N +L Sbjct: 80 EHLDQDLKKLLDVCDGGLESVTAKSFLLQLLSGIAYCHEHRVLHRDLKPQNLLINREGEL 139 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 KI DFGLAR T VVT WYRAP++L+ S YS ID+WSVGCIF E++N P Sbjct: 140 KIADFGLARAFGIPVRKYTHEVVTLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRP 199 Query: 442 LFPGRDHMHQMRLITEVIGTP 504 LFPG Q+ I ++GTP Sbjct: 200 LFPGVSETDQLMRIFRILGTP 220
>CDK6_HUMAN (Q00534) Cell division protein kinase 6 (EC 2.7.11.22)| (Serine/threonine-protein kinase PLSTIRE) Length = 326 Score = 126 bits (317), Expect = 3e-29 Identities = 60/118 (50%), Positives = 83/118 (70%) Frame = +1 Query: 163 LYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWY 342 ++QLLRGL ++HS V+HRDLKP N+L+ ++ +K+ DFGLAR S +T VVT WY Sbjct: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWY 185 Query: 343 RAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 RAPE+LL S+ Y+ +D+WSVGCIF E+ R PLF G + Q+ I +VIG P ++D Sbjct: 186 RAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242
>BUR1_ASPFU (Q4WTN5) Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 580 Score = 126 bits (317), Expect = 3e-29 Identities = 64/162 (39%), Positives = 96/162 (59%), Gaps = 13/162 (8%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 +Y+ T M+ DL ++ + +E + ++ QLL GLKY+H ++HRD+K +NLL++ Sbjct: 105 MYMVTPYMEHDLSGLLENPAVNFTEPQIKCYMLQLLEGLKYLHGNRILHRDMKAANLLIS 164 Query: 250 ANCDLKICDFGLARPSSESDM------------MTEYVVTRWYRAPELLLNSTDYSAAID 393 N L+I DFGLARP E T VVTRWYR PELLL Y+ AID Sbjct: 165 NNGVLQIADFGLARPYDEPPPEPGKGGGEAKRDYTTLVVTRWYRPPELLLQLRRYTTAID 224 Query: 394 VWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 +W VGC+F E+ P+ G ++Q +LI ++GTPT++++ Sbjct: 225 MWGVGCVFGEMFKGKPILAGSSDLNQTQLIFNLVGTPTEENM 266
>CDK5_DROME (P48609) Cell division protein kinase 5 homolog (EC 2.7.11.22)| Length = 294 Score = 126 bits (317), Expect = 3e-29 Identities = 69/145 (47%), Positives = 89/145 (61%), Gaps = 3/145 (2%) Frame = +1 Query: 88 ELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E D DL S N E+ C+ F+ QLLRGL + HS NV+HRDLKP NLL+N N +L Sbjct: 81 EHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGEL 140 Query: 265 KICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRA- 438 K+ DFGLAR + VVT WYR P++L + Y+ +ID+WS GCI EL + Sbjct: 141 KLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGR 200 Query: 439 PLFPGRDHMHQMRLITEVIGTPTDD 513 PLFPG D + Q+ I V+GTP +D Sbjct: 201 PLFPGSDVLDQLMKIFRVLGTPNED 225
>GSK3H_DICDI (P51136) Glycogen synthase kinase-3 homolog (EC 2.7.11.26) (GSK-3)| Length = 467 Score = 126 bits (316), Expect = 4e-29 Identities = 59/137 (43%), Positives = 87/137 (63%), Gaps = 1/137 (0%) Frame = +1 Query: 112 HIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCD-LKICDFGLA 288 H S Q + + ++YQL R + YIHS + HRD+KP NLLL+ + LK+CDFG A Sbjct: 143 HYSMSKQPVPNIFVKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTSTSTLKLCDFGSA 202 Query: 289 RPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMH 468 + + + Y+ +R YRAPEL+ ST+Y+ IDVWS+GC+ EL+ PLFPG + + Sbjct: 203 KILIKGETNVSYICSRHYRAPELIFGSTNYTTTIDVWSLGCVLAELLLGQPLFPGENGID 262 Query: 469 QMRLITEVIGTPTDDDL 519 Q+ I +V+GTPT + + Sbjct: 263 QLVEIIKVLGTPTKEQI 279
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 126 bits (316), Expect = 4e-29 Identities = 64/155 (41%), Positives = 94/155 (60%), Gaps = 7/155 (4%) Frame = +1 Query: 67 NDVYIATELMDTDLHHII------RSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLK 228 N + + E MD DL + S++ L + +YF +QLL+G+ + H ++HRDLK Sbjct: 76 NKLTLVFEFMDNDLKKFMDNRNKGNSHKGLEMDLVKYFQWQLLQGVAFCHENRILHRDLK 135 Query: 229 PSNLLLNANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 P NLL+N LK+ DFGLAR + + VVT WYRAP++L+ S +Y +ID+WS Sbjct: 136 PQNLLINNRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRNYCTSIDIWSC 195 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 GCI E+I PLFPG + Q++LI + +GTP + Sbjct: 196 GCILAEMIMGKPLFPGSNDEEQLKLIFDTMGTPVE 230
>CDK6_MOUSE (Q64261) Cell division protein kinase 6 (EC 2.7.11.22)| (Serine/threonine-protein kinase PLSTIRE) (CRK2) Length = 326 Score = 126 bits (316), Expect = 4e-29 Identities = 59/118 (50%), Positives = 83/118 (70%) Frame = +1 Query: 163 LYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMMTEYVVTRWY 342 ++QLLRGL ++HS V+HRDLKP N+L+ ++ +K+ DFGLAR S +T VVT WY Sbjct: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWY 185 Query: 343 RAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 RAPE+LL S+ Y+ +D+WSVGCIF E+ R PLF G + Q+ I ++IG P ++D Sbjct: 186 RAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEED 242
>CDK2_RAT (Q63699) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 126 bits (316), Expect = 4e-29 Identities = 66/151 (43%), Positives = 91/151 (60%), Gaps = 3/151 (1%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQ--ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNL 240 N +Y+ E + DL + ++ L + +L+QLL+GL + HS V+HRDLKP NL Sbjct: 74 NKLYLVFEFLHQDLKKFMDASALTGLPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 241 LLNANCDLKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L+NA +K+ DFGLAR T VVT WYRAPE+LL YS A+D+WS+GCIF Sbjct: 134 LINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIF 193 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 E++ R LFPG + Q+ I +GTP + Sbjct: 194 AEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224
>KSG6_ARATH (Q39010) Shaggy-related protein kinase dzeta (EC 2.7.11.1)| (ASK-dzeta) Length = 412 Score = 126 bits (316), Expect = 4e-29 Identities = 59/140 (42%), Positives = 93/140 (66%), Gaps = 2/140 (1%) Frame = +1 Query: 106 LHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA-NVIHRDLKPSNLLLNANC-DLKICDF 279 L H SNQ + + + + YQ+ RGL YIH+A V HRD+KP NLL++ + K+CDF Sbjct: 158 LKHYTSSNQRMPIFYVKLYTYQIFRGLAYIHTAPGVCHRDIKPQNLLVDPHTHQCKLCDF 217 Query: 280 GLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRD 459 G A+ + + Y+ +R+YRAPEL+ +T+Y+++ID+WS GC+ EL+ PLFPG + Sbjct: 218 GSAKVLVKGEPNISYICSRYYRAPELIFGATEYTSSIDIWSAGCVLAELLLGQPLFPGEN 277 Query: 460 HMHQMRLITEVIGTPTDDDL 519 + Q+ I +V+GTPT +++ Sbjct: 278 SVDQLVEIIKVLGTPTREEI 297
>MOK_HUMAN (Q9UQ07) MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK| protein kinase) (Renal tumor antigen 1) (RAGE-1) Length = 419 Score = 126 bits (316), Expect = 4e-29 Identities = 61/140 (43%), Positives = 89/140 (63%), Gaps = 1/140 (0%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 ELMD +++ +IR + LSE+ +++YQL + L +IH + HRD+KP N+L+ + L Sbjct: 83 ELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKQDV-L 141 Query: 265 KICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPL 444 K+ DFG R TEY+ TRWYRAPE LL Y+ +D+WS GC+F E+ + PL Sbjct: 142 KLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPL 201 Query: 445 FPGRDHMHQMRLITEVIGTP 504 FPG + + Q+ I +VIGTP Sbjct: 202 FPGVNELDQISKIHDVIGTP 221
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 125 bits (315), Expect = 6e-29 Identities = 65/151 (43%), Positives = 92/151 (60%), Gaps = 3/151 (1%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQ--ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNL 240 N +Y+ E + DL + ++ + + +L+QLL+GL + HS V+HRDLKP NL Sbjct: 74 NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 241 LLNANCDLKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L+NA+ +K+ DFGLAR T VVT WYRAPE+LL YS A+D+WS+GCIF Sbjct: 134 LINADGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIF 193 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 E++ R LFPG + Q+ I +GTP + Sbjct: 194 AEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224
>MAK_MOUSE (Q04859) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) (Protein kinase RCK) Length = 622 Score = 125 bits (315), Expect = 6e-29 Identities = 65/149 (43%), Positives = 89/149 (59%), Gaps = 1/149 (0%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHC-QYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 +Y E M +L+ +++ +L E + +YQ+L+GL +IH HRD+KP NLL Sbjct: 75 LYFVFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCM 134 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 +KI DFGLAR T+YV TRWYRAPE+LL S+ YS+ IDVW+VG I EL Sbjct: 135 GPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELY 194 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 PLFPG + ++ I +V+GTP D Sbjct: 195 TFRPLFPGTSEVDEIFKICQVLGTPKKSD 223
>CD2L1_MOUSE (P24788) PITSLRE serine/threonine-protein kinase CDC2L1 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) Length = 784 Score = 125 bits (315), Expect = 6e-29 Identities = 66/155 (42%), Positives = 97/155 (62%), Gaps = 2/155 (1%) Frame = +1 Query: 52 IPQSFNDVYIATELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLK 228 + + + +YI ++ DL ++ + Q + + QLL G+K++H ++HRDLK Sbjct: 494 VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLK 553 Query: 229 PSNLLLNANCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 SNLLL+ LK+ DFGLAR S T VVT WYRAPELLL + +YS A+D+WSV Sbjct: 554 TSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSV 613 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 GCIF EL+ + PLFPG+ + Q+ I + +GTP++ Sbjct: 614 GCIFGELLTQKPLFPGKSDIDQINKIFKDLGTPSE 648
>CDKL1_HUMAN (Q00532) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIALRE) (Protein kinase p42 KKIALRE) Length = 357 Score = 125 bits (314), Expect = 7e-29 Identities = 56/134 (41%), Positives = 86/134 (64%), Gaps = 1/134 (0%) Frame = +1 Query: 100 TDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDF 279 T LH + R + + E + +Q L+ + + H N IHRD+KP N+L+ + +K+CDF Sbjct: 86 TVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDF 145 Query: 280 GLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGR 456 G AR + SD T+YV TRWYR+PELL+ T Y +DVW++GC+F EL++ PL+PG+ Sbjct: 146 GFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGK 205 Query: 457 DHMHQMRLITEVIG 498 + Q+ LI + +G Sbjct: 206 SDVDQLYLIRKTLG 219
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 125 bits (314), Expect = 7e-29 Identities = 65/151 (43%), Positives = 91/151 (60%), Gaps = 3/151 (1%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQE--LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNL 240 N +Y+ E + DL + ++ + + +L+QLL+GL + HS V+HRDLKP NL Sbjct: 74 NKLYLVFEFLHQDLKKFMDASAVTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 241 LLNANCDLKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L+NA +K+ DFGLAR T VVT WYRAPE+LL YS A+D+WS+GCIF Sbjct: 134 LINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIF 193 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 E++ R LFPG + Q+ I +GTP + Sbjct: 194 AEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224
>KSG9_ARATH (Q39012) Shaggy-related protein kinase iota (EC 2.7.11.1)| (ASK-iota) Length = 407 Score = 125 bits (314), Expect = 7e-29 Identities = 59/140 (42%), Positives = 92/140 (65%), Gaps = 2/140 (1%) Frame = +1 Query: 106 LHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA-NVIHRDLKPSNLLLNA-NCDLKICDF 279 L H SNQ + + + + YQ+ RGL YIH+ V HRD+KP NLL++ +K+CDF Sbjct: 156 LRHYTSSNQRMPIFYVKLYTYQIFRGLAYIHTVPGVCHRDVKPQNLLVDPLTHQVKLCDF 215 Query: 280 GLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRD 459 G A+ + + Y+ +R+YRAPEL+ +T+Y+A+ID+WS GC+ EL+ PLFPG + Sbjct: 216 GSAKVLVKGEPNISYICSRYYRAPELIFGATEYTASIDIWSAGCVLAELLLGQPLFPGEN 275 Query: 460 HMHQMRLITEVIGTPTDDDL 519 + Q+ I +V+GTPT +++ Sbjct: 276 SVDQLVEIIKVLGTPTREEI 295
>MAK_RAT (P20793) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 622 Score = 125 bits (314), Expect = 7e-29 Identities = 65/149 (43%), Positives = 89/149 (59%), Gaps = 1/149 (0%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHC-QYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 +Y E M +L+ +++ +L E + +YQ+L+GL +IH HRD+KP NLL Sbjct: 75 LYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCM 134 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 +KI DFGLAR T+YV TRWYRAPE+LL S+ YS+ IDVW+VG I EL Sbjct: 135 GPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELY 194 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 PLFPG + ++ I +V+GTP D Sbjct: 195 TFRPLFPGTSEVDEIFKICQVLGTPKKSD 223
>CDC2D_ANTMA (Q38775) Cell division control protein 2 homolog D (EC 2.7.11.22)| (EC 2.7.11.23) Length = 312 Score = 125 bits (314), Expect = 7e-29 Identities = 66/153 (43%), Positives = 94/153 (61%), Gaps = 6/153 (3%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEE----HCQYFLYQLLRGLKYIHSANVIHRDLKPSNL 240 +Y+ E MDTDL IRS ++ E + + +YQL +G+ + H V+HRDLKP NL Sbjct: 92 LYLVFEYMDTDLKKYIRSFKQTGESIAPMNVKSLMYQLCKGVAFCHGHGVLHRDLKPHNL 151 Query: 241 LLNANCD-LKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCI 414 L++ LKI D GLAR + T ++T WYRAPE+LL +T YS A+D+WSV CI Sbjct: 152 LMDRKTMMLKIADLGLARAYTLPIKKYTHEILTLWYRAPEVLLGATHYSPAVDMWSVACI 211 Query: 415 FMELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 F EL+ + LFPG + Q+ I ++GTP ++ Sbjct: 212 FAELVTQKALFPGDSELQQLLHIFRLLGTPNEE 244
>MAK_HUMAN (P20794) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 623 Score = 125 bits (313), Expect = 9e-29 Identities = 65/149 (43%), Positives = 89/149 (59%), Gaps = 1/149 (0%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQELSEEHC-QYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 +Y E M +L+ +++ +L E + +YQ+L+GL +IH HRD+KP NLL Sbjct: 75 LYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCM 134 Query: 250 ANCDLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 +KI DFGLAR T+YV TRWYRAPE+LL S+ YS+ IDVW+VG I EL Sbjct: 135 GPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELY 194 Query: 430 NRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 PLFPG + ++ I +V+GTP D Sbjct: 195 MLRPLFPGTSEVDEIFKICQVLGTPKKSD 223
>CDK7_DICDI (P54685) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (MO15 homolog) Length = 362 Score = 125 bits (313), Expect = 9e-29 Identities = 63/152 (41%), Positives = 93/152 (61%), Gaps = 2/152 (1%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQE-LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 ++VY+ ELM DL +I L + ++ LL+G++ H V+HRDLKP+NLL Sbjct: 78 SNVYLVFELMQWDLQEVIEDKSIILKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLL 137 Query: 244 LNANCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 ++ N DLK+ DFGLAR S + + + VT +YRAPELL + Y ++D+WS+GCIF Sbjct: 138 MSINGDLKLADFGLARQYGSPNKVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFA 197 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 EL+ R P PG + Q+R I +GTP + + Sbjct: 198 ELMLRTPYLPGTGEIDQLRKICSALGTPNESN 229
>MSK3_MEDSA (P51139) Glycogen synthase kinase-3 homolog MsK-3 (EC 2.7.11.1)| Length = 411 Score = 125 bits (313), Expect = 9e-29 Identities = 61/146 (41%), Positives = 92/146 (63%), Gaps = 2/146 (1%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIH-SANVIHRDLKPSNLLLNANC-D 261 E + + H + NQ + + + + YQ+ R L YIH S V HRD+KP NLL+N + Sbjct: 154 ETVSRVIRHYNKMNQRMPMIYVKLYSYQICRALAYIHNSIGVCHRDIKPQNLLVNPHTHQ 213 Query: 262 LKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 LKICDFG A+ + + Y+ +R+YRAPEL+ +T+Y+ AID+WS GC+ EL+ P Sbjct: 214 LKICDFGSAKVLVKGEPNISYICSRYYRAPELIFGATEYTTAIDIWSAGCVLGELLLGQP 273 Query: 442 LFPGRDHMHQMRLITEVIGTPTDDDL 519 LFPG + Q+ I +V+GTPT +++ Sbjct: 274 LFPGESGVDQLVEIIKVLGTPTREEI 299
>BUR1_EMENI (Q96VK3) Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC| 2.7.11.23) (Pitalre-like kinase A) Length = 544 Score = 124 bits (312), Expect = 1e-28 Identities = 63/162 (38%), Positives = 97/162 (59%), Gaps = 13/162 (8%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 +Y+ M+ DL ++ + + SE + ++ QLL GLKY+H ++HRD+K +NLL++ Sbjct: 105 MYMVFPYMEHDLSGLLENPEVHFSEAQIKCYMIQLLEGLKYLHGNCILHRDMKAANLLIS 164 Query: 250 ANCDLKICDFGLARPSSESDMM------------TEYVVTRWYRAPELLLNSTDYSAAID 393 L+I DFGLARP E+ T VVTRWYR PELLL Y++AID Sbjct: 165 NQGILQIADFGLARPFDEAPPQPGKGAGEAKRDYTTLVVTRWYRPPELLLQLRRYTSAID 224 Query: 394 VWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 +W VGC+F E+ P+ G ++Q +LI ++GTPT++++ Sbjct: 225 MWGVGCVFGEMFKGKPILAGNSDLNQAQLIFSLVGTPTEENM 266
>CD2L7_CAEEL (P46551) Putative cell division cycle 2-related protein kinase 7| (EC 2.7.11.22) Length = 730 Score = 124 bits (312), Expect = 1e-28 Identities = 68/151 (45%), Positives = 91/151 (60%), Gaps = 4/151 (2%) Frame = +1 Query: 76 YIATELMDTDLHHIIRSNQELS---EEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 Y+ E +D DL ++ S + + ++ C F QLL GL YIH+ +HRD+K SN+L+ Sbjct: 394 YLVFEYVDHDLIGLLESKELVDFNKDQICSLFK-QLLEGLAYIHNTGFLHRDIKCSNILV 452 Query: 247 NANCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 N +LKI D GLAR ES + T V+T WYR PELLL Y AIDVWS GC+ E Sbjct: 453 NNKGELKIADLGLARLWEKESRLYTNRVITLWYRPPELLLGDERYGPAIDVWSTGCMLGE 512 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 L R PLF G + Q+ LI++V G+P D+ Sbjct: 513 LFTRKPLFNGNNEFGQLELISKVCGSPNVDN 543
>CDKL2_RABIT (Q9TTK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 566 Score = 124 bits (312), Expect = 1e-28 Identities = 58/143 (40%), Positives = 92/143 (64%), Gaps = 2/143 (1%) Frame = +1 Query: 76 YIATELMD-TDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNA 252 Y+ E +D T L + L ++ Q +L+Q++ G+ + HS N+IHRD+KP N+L++ Sbjct: 77 YLVFEFVDHTILDDLELFPNGLDDQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQ 136 Query: 253 NCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 + +K+CDFG AR ++ ++ T+YV TRWYRAPELL+ Y A+DVW++GC+ E++ Sbjct: 137 SGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEML 196 Query: 430 NRAPLFPGRDHMHQMRLITEVIG 498 PLFPG + Q+ LI +G Sbjct: 197 MGEPLFPGDSDIDQLYLIMRCLG 219
>CD2L1_RAT (P46892) PITSLRE serine/threonine-protein kinase CDC2L1 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) Length = 436 Score = 124 bits (312), Expect = 1e-28 Identities = 67/155 (43%), Positives = 95/155 (61%), Gaps = 2/155 (1%) Frame = +1 Query: 52 IPQSFNDVYIATELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLK 228 + + + +YI ++ DL ++ + Q + + QLL G+K++H ++HRDLK Sbjct: 146 VGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLK 205 Query: 229 PSNLLLNANCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 SNLLL LK+ DFGLAR S T VVT WYRAPELLL + +YS A D+WSV Sbjct: 206 TSNLLLTHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTACDMWSV 265 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 GCIF EL+ + PLFPG+ + Q+ I + IGTP++ Sbjct: 266 GCIFGELLTQKPLFPGKSDIDQINKIFKDIGTPSE 300
>CDC2B_ARATH (P25859) Cell division control protein 2 homolog B (EC 2.7.11.22)| (EC 2.7.11.23) Length = 309 Score = 124 bits (311), Expect = 2e-28 Identities = 68/156 (43%), Positives = 94/156 (60%), Gaps = 8/156 (5%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQE------LSEEHCQYFLYQLLRGLKYIHSANVIHRDLK 228 +++Y+ E +DTDL I S ++ L Q ++QL +G+ + HS V+HRDLK Sbjct: 85 SNLYLVFEYLDTDLKKFIDSYRKGPNPKPLEPFLIQKLMFQLCKGVAHCHSHGVLHRDLK 144 Query: 229 PSNLLLNANCDL-KICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 P NLLL + +L KI D GL R + T +VT WYRAPE+LL ST YS +D+WS Sbjct: 145 PQNLLLVKDKELLKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEVLLGSTHYSTGVDMWS 204 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 VGCIF E++ R LFPG Q+ I ++GTPT+ Sbjct: 205 VGCIFAEMVRRQALFPGDSEFQQLLHIFRLLGTPTE 240
>MOK_MOUSE (Q9WVS4) MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK| protein kinase) Length = 420 Score = 124 bits (311), Expect = 2e-28 Identities = 61/145 (42%), Positives = 89/145 (61%), Gaps = 1/145 (0%) Frame = +1 Query: 88 ELMDTDLHHIIRSNQE-LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 ELMD +++ +IR + LSE+ ++YQL + L ++H + HRD+KP N+L+ + L Sbjct: 83 ELMDMNIYELIRGRRHPLSEKKIMLYMYQLCKSLDHMHRNGIFHRDVKPENILVKQDV-L 141 Query: 265 KICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPL 444 K+ DFG R TEY+ TRWYRAPE LL Y+ +D+WS GC+F E+ + PL Sbjct: 142 KLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPL 201 Query: 445 FPGRDHMHQMRLITEVIGTPTDDDL 519 FPG + + Q+ I +VIGTP L Sbjct: 202 FPGVNELDQISKIHDVIGTPCQKTL 226
>GSK3A_HUMAN (P49840) Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3| alpha) Length = 483 Score = 124 bits (310), Expect = 2e-28 Identities = 57/137 (41%), Positives = 88/137 (64%), Gaps = 1/137 (0%) Frame = +1 Query: 112 HIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCD-LKICDFGLA 288 H ++ + + + ++YQL R L YIHS V HRD+KP NLL++ + LK+CDFG A Sbjct: 208 HFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSA 267 Query: 289 RPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMH 468 + + Y+ +R+YRAPEL+ +TDY+++IDVWS GC+ EL+ P+FPG + Sbjct: 268 KQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVD 327 Query: 469 QMRLITEVIGTPTDDDL 519 Q+ I +V+GTPT + + Sbjct: 328 QLVEIIKVLGTPTREQI 344
>CDKL4_HUMAN (Q5MAI5) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 315 Score = 124 bits (310), Expect = 2e-28 Identities = 55/133 (41%), Positives = 85/133 (63%) Frame = +1 Query: 100 TDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDF 279 T L+ + R+ +++ + L+Q L+ L + H N IHRD+KP N+L+ +KICDF Sbjct: 86 TLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDF 145 Query: 280 GLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRD 459 G A+ D T+YV TRWYRAPELL+ T Y +++D+W++GC+F EL+ PL+PG+ Sbjct: 146 GFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKS 205 Query: 460 HMHQMRLITEVIG 498 + Q+ LI +G Sbjct: 206 DVDQLYLIIRTLG 218
>MSK1_MEDSA (P51137) Glycogen synthase kinase-3 homolog MsK-1 (EC 2.7.11.1)| Length = 411 Score = 124 bits (310), Expect = 2e-28 Identities = 59/140 (42%), Positives = 90/140 (64%), Gaps = 2/140 (1%) Frame = +1 Query: 106 LHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA-NVIHRDLKPSNLLLNANC-DLKICDF 279 + H + NQ + + + + YQ+ R L YIH V HRD+KP NLL+N + +K+CDF Sbjct: 161 IKHYSKLNQRMPMIYVKLYTYQIFRALSYIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDF 220 Query: 280 GLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRD 459 G A+ + + Y+ +R+YRAPEL+ +T+Y+ AIDVWSVGC+ EL+ PLFPG Sbjct: 221 GSAKVLVKGEPNISYICSRYYRAPELIFGATEYTTAIDVWSVGCVLAELLLGQPLFPGER 280 Query: 460 HMHQMRLITEVIGTPTDDDL 519 + Q+ I +V+GTPT +++ Sbjct: 281 GVDQLVEIIKVLGTPTREEI 300
>YP62_CAEEL (Q09437) Putative serine/threonine-protein kinase B0495.2 (EC| 2.7.11.1) Length = 719 Score = 124 bits (310), Expect = 2e-28 Identities = 66/155 (42%), Positives = 95/155 (61%), Gaps = 5/155 (3%) Frame = +1 Query: 61 SFNDVYIATELMDTDLHHII----RSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLK 228 + + +Y+A E ++ D+ ++ R N+ S + L QLL G++++H ++HRDLK Sbjct: 427 NMDKIYMAMEFVEHDMKSLLDTMSRRNKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLK 486 Query: 229 PSNLLLNANCDLKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 SNLL++ LKI DFGLAR + T VVT WYR+PELLL + YS +D+WSV Sbjct: 487 TSNLLMSHKGILKIADFGLAREYGDPLKKFTSIVVTLWYRSPELLLGTRLYSTPVDMWSV 546 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 GCI E I PLFPGR + Q++ I +GTPT+ Sbjct: 547 GCIMAEFILLKPLFPGRGELEQIKKIFMEMGTPTE 581
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 123 bits (309), Expect = 3e-28 Identities = 65/155 (41%), Positives = 90/155 (58%), Gaps = 7/155 (4%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSN------QELSEEHCQYFLYQLLRGLKYIHSANVIHRDLK 228 N + + E MD DL + S + L +YF +QLL GL + H ++HRDLK Sbjct: 75 NKLTLVFEYMDNDLKKYMDSRTVGNAPRGLEMNLVKYFQWQLLEGLAFCHENKILHRDLK 134 Query: 229 PSNLLLNANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 P NLL+ LK+ DFGLAR + + VVT WYRAP++L+ S YS +ID+WS Sbjct: 135 PQNLLITKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSC 194 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 GCI E+I PLFPG + Q++LI + +GTP + Sbjct: 195 GCILAEMITGKPLFPGTNDEEQLKLIFDKMGTPNE 229
>BUR1_GIBZE (Q4I5U9) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 473 Score = 123 bits (309), Expect = 3e-28 Identities = 65/162 (40%), Positives = 98/162 (60%), Gaps = 13/162 (8%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 VY+AT MD DL ++ + + + E + ++ QLL GL+Y+H + ++HRD+K +NLL+N Sbjct: 119 VYMATPYMDHDLSGLLDNPSVQFKEPQIKCYMLQLLEGLRYLHDSRILHRDMKAANLLIN 178 Query: 250 ANCDLKICDFGLAR------PSSESDM------MTEYVVTRWYRAPELLLNSTDYSAAID 393 L+I DFGLAR P S M T VVTRWYR PELLL Y+ AID Sbjct: 179 NKGILQIADFGLARHYDGRTPESGVPMGEGKRDYTGLVVTRWYRPPELLLQLRQYTPAID 238 Query: 394 VWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 VW VGC+F E++ P+ G Q+ +I +++G+P ++++ Sbjct: 239 VWGVGCVFGEMLYGKPILAGESDAAQLDIIWDLMGSPNEENM 280
>CDKL1_RAT (Q66HE7) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 123 bits (309), Expect = 3e-28 Identities = 55/134 (41%), Positives = 85/134 (63%), Gaps = 1/134 (0%) Frame = +1 Query: 100 TDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDF 279 T LH + R + + E + +Q L+ + + H N IHRD+KP N+L+ + +K+CDF Sbjct: 86 TVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDF 145 Query: 280 GLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGR 456 G AR + D T+YV TRWYR+PELL+ T Y +DVW++GC+F EL++ PL+PG+ Sbjct: 146 GFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGK 205 Query: 457 DHMHQMRLITEVIG 498 + Q+ LI + +G Sbjct: 206 SDVDQLYLIRKTLG 219
>CDKL1_MOUSE (Q8CEQ0) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 123 bits (309), Expect = 3e-28 Identities = 55/134 (41%), Positives = 84/134 (62%), Gaps = 1/134 (0%) Frame = +1 Query: 100 TDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDF 279 T LH + R + + E + +Q L+ + + H N IHRD+KP N+L+ +K+CDF Sbjct: 86 TVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQSAIKLCDF 145 Query: 280 GLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGR 456 G AR + D T+YV TRWYR+PELL+ T Y +DVW++GC+F EL++ PL+PG+ Sbjct: 146 GFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGK 205 Query: 457 DHMHQMRLITEVIG 498 + Q+ LI + +G Sbjct: 206 SDVDQLYLIRKTLG 219
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 123 bits (308), Expect = 4e-28 Identities = 65/155 (41%), Positives = 91/155 (58%), Gaps = 7/155 (4%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQE------LSEEHCQYFLYQLLRGLKYIHSANVIHRDLK 228 N + + E MD DL + S + L +YF +QLL+G+ + H ++HRDLK Sbjct: 78 NKLTLVFEFMDNDLKKFMDSRLDREMPRGLELSLVKYFQWQLLQGVAFCHENRILHRDLK 137 Query: 229 PSNLLLNANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 P NLL+N LK+ DFGLAR + + VVT WYRAP++L+ S Y +ID+WS Sbjct: 138 PQNLLINNKGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYCTSIDIWSC 197 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 GCI E+I LFPG + Q++LI E +GTPT+ Sbjct: 198 GCILAEMIMGKALFPGTNDDEQLKLIFETMGTPTE 232
>CC2H1_TRYCO (P54664) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 123 bits (308), Expect = 4e-28 Identities = 64/151 (42%), Positives = 92/151 (60%), Gaps = 2/151 (1%) Frame = +1 Query: 61 SFNDVYIATELMDTDLH-HIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 S N + + E M+ DL ++ R++ L Q F+ LL+G+++ H NV+HRDLKP N Sbjct: 73 SENRLNLVFEYMEMDLKKYMDRASGNLDPATIQEFMRSLLKGVRFCHERNVLHRDLKPPN 132 Query: 238 LLLNANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCI 414 LL++ +LK+ DFGL R T VVT WYR+P++LL ST Y +D+WSVGCI Sbjct: 133 LLISREKELKLADFGLGRAFGIPVKKYTHEVVTLWYRSPDVLLGSTQYGTPVDIWSVGCI 192 Query: 415 FMELINRAPLFPGRDHMHQMRLITEVIGTPT 507 F E+ APLF G++ Q+ I +GTP+ Sbjct: 193 FAEMAIGAPLFAGKNDADQLLRIFRFLGTPS 223
>CDK2_HUMAN (P24941) Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein| kinase) Length = 298 Score = 123 bits (308), Expect = 4e-28 Identities = 64/151 (42%), Positives = 90/151 (59%), Gaps = 3/151 (1%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQ--ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNL 240 N +Y+ E + DL + ++ + + +L+QLL+GL + HS V+HRDLKP NL Sbjct: 74 NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Query: 241 LLNANCDLKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIF 417 L+N +K+ DFGLAR T VVT WYRAPE+LL YS A+D+WS+GCIF Sbjct: 134 LINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIF 193 Query: 418 MELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 E++ R LFPG + Q+ I +GTP + Sbjct: 194 AEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224
>MSK2_MEDSA (P51138) Glycogen synthase kinase-3 homolog MsK-2 (EC 2.7.11.1)| Length = 411 Score = 123 bits (308), Expect = 4e-28 Identities = 61/153 (39%), Positives = 96/153 (62%), Gaps = 6/153 (3%) Frame = +1 Query: 79 IATELMDTDLHHIIRS----NQELSEEHCQYFLYQLLRGLKYIHSA-NVIHRDLKPSNLL 243 + E + +H +IR NQ + + + + YQ+ R L YIH+ V HRD+KP NLL Sbjct: 147 LVLEFVPETVHRVIRHYSKMNQRMPLIYVKLYSYQICRSLAYIHNCVGVSHRDIKPQNLL 206 Query: 244 LNANC-DLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 +N + LK+CDFG A+ + + Y+ +R+YRAPEL+ +T+Y++AID+WS GC+ Sbjct: 207 VNPHTHQLKLCDFGSAKVLVKGEPNISYICSRYYRAPELIFGATEYTSAIDIWSAGCVLG 266 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 EL+ PLFPG + Q+ I +V+GTPT +++ Sbjct: 267 ELLLGQPLFPGASGVDQLVEIIKVLGTPTREEI 299
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 123 bits (308), Expect = 4e-28 Identities = 64/152 (42%), Positives = 93/152 (61%), Gaps = 4/152 (2%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQE---LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 N + + E MD DL + ++ L + + F++QLL+G+ + H V+HRDLKP N Sbjct: 77 NKLTLVFEFMDKDLKKYMEAHGNQGALDLKIVKSFIFQLLKGIMFCHDNRVLHRDLKPQN 136 Query: 238 LLLNANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCI 414 LL+N +LK+ DFGLAR + + VVT WYRAP++LL S Y+A+ID+WS GCI Sbjct: 137 LLINNKGELKLGDFGLARAFGIPFNTFSNEVVTLWYRAPDVLLGSRAYTASIDIWSAGCI 196 Query: 415 FMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 F E+ PLFPG + Q+ I ++GTP + Sbjct: 197 FAEMCTGKPLFPGTSNDDQLIKIFRLMGTPNE 228
>BUR1_DEBHA (Q6BV06) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 608 Score = 123 bits (308), Expect = 4e-28 Identities = 63/156 (40%), Positives = 89/156 (57%), Gaps = 13/156 (8%) Frame = +1 Query: 76 YIATELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNA 252 Y + M +DL ++ + N L H + F+ QLL G++YIH +HRD+K +N+L++ Sbjct: 125 YTVSPYMCSDLVGLLENPNINLEVSHIKCFMEQLLHGIQYIHEQMFLHRDIKAANILIDR 184 Query: 253 NCDLKICDFGLAR------------PSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDV 396 N LKI DFGLAR P T VVTRWYR PELLL Y+ A+D+ Sbjct: 185 NGTLKIADFGLARVYHGSPPKFMSGPGGGERAYTGLVVTRWYRPPELLLGERRYTTAVDM 244 Query: 397 WSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 W +GC+F EL R P+ G+ HQ +LI +++G P Sbjct: 245 WGIGCVFGELFTRKPILVGKTDSHQAQLIFDLVGPP 280
>GSK3A_RAT (P18265) Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3| alpha) (Factor A) (FA) Length = 483 Score = 123 bits (308), Expect = 4e-28 Identities = 56/125 (44%), Positives = 84/125 (67%), Gaps = 1/125 (0%) Frame = +1 Query: 148 HCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCD-LKICDFGLARPSSESDMMTEY 324 + + ++YQL R L YIHS V HRD+KP NLL++ + LK+CDFG A+ + Y Sbjct: 220 YVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY 279 Query: 325 VVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTP 504 + +R+YRAPEL+ +TDY+++IDVWS GC+ EL+ P+FPG + Q+ I +V+GTP Sbjct: 280 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 339 Query: 505 TDDDL 519 T + + Sbjct: 340 TREQI 344
>KSG4_ARATH (Q9FVS6) Shaggy-related protein kinase delta (EC 2.7.11.1)| (ASK-delta) Length = 420 Score = 122 bits (307), Expect = 5e-28 Identities = 58/135 (42%), Positives = 89/135 (65%), Gaps = 2/135 (1%) Frame = +1 Query: 121 RSNQELSEEHCQYFLYQLLRGLKYIHSA-NVIHRDLKPSNLLLNANC-DLKICDFGLARP 294 R NQ + + + + YQ+ RGL Y+H+ + HRD+KP NLL+N + LKICDFG A+ Sbjct: 173 RMNQLMPLIYVKLYTYQICRGLAYLHNCCGLCHRDIKPQNLLVNPHTHQLKICDFGSAKV 232 Query: 295 SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQM 474 + + Y+ +R+YRAPEL+ +T+Y+ AID+WS GC+ EL+ PLFPG + Q+ Sbjct: 233 LVKGEPNISYICSRYYRAPELIFGATEYTTAIDIWSTGCVMAELLLGQPLFPGESGVDQL 292 Query: 475 RLITEVIGTPTDDDL 519 I +V+GTPT +++ Sbjct: 293 VEIIKVLGTPTREEI 307
>KSG3_ARATH (P43289) Shaggy-related protein kinase gamma (EC 2.7.11.1)| (ASK-gamma) Length = 409 Score = 122 bits (307), Expect = 5e-28 Identities = 58/140 (41%), Positives = 89/140 (63%), Gaps = 2/140 (1%) Frame = +1 Query: 106 LHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA-NVIHRDLKPSNLLLNANC-DLKICDF 279 + H + NQ + + + + YQ+ R L YIH V HRD+KP NLL+N + +K+CDF Sbjct: 159 IKHYNKLNQRMPLVYVKLYTYQIFRSLSYIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDF 218 Query: 280 GLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRD 459 G A+ + + Y+ +R+YRAPEL+ +T+Y+ AIDVWS GC+ EL+ PLFPG Sbjct: 219 GSAKVLVKGEPNISYICSRYYRAPELIFGATEYTTAIDVWSAGCVLAELLLGQPLFPGES 278 Query: 460 HMHQMRLITEVIGTPTDDDL 519 + Q+ I +V+GTPT +++ Sbjct: 279 GVDQLVEIIKVLGTPTREEI 298
>GSK3_SCHPO (Q10452) Protein kinase gsk3 (EC 2.7.11.1) (Protein kinaae skp1)| Length = 387 Score = 122 bits (307), Expect = 5e-28 Identities = 56/121 (46%), Positives = 83/121 (68%), Gaps = 1/121 (0%) Frame = +1 Query: 160 FLYQLLRGLKYIHSANVIHRDLKPSNLLLNA-NCDLKICDFGLARPSSESDMMTEYVVTR 336 ++YQLLR L YIH++ + HRD+KP NLLL+ N LK+CDFG A+ + Y+ +R Sbjct: 137 YIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKILVAGEPNVSYICSR 196 Query: 337 WYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDD 516 +YRAPEL+ +TDY+ AID+WS GC+ EL+ PLFPG + Q+ I +++GTP+ + Sbjct: 197 YYRAPELIFGATDYTHAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGTPSREQ 256 Query: 517 L 519 + Sbjct: 257 I 257
>KSG5_ARATH (Q8VZD5) Shaggy-related protein kinase epsilon (EC 2.7.11.1)| (ASK-epsilon) Length = 410 Score = 122 bits (306), Expect = 6e-28 Identities = 57/138 (41%), Positives = 88/138 (63%), Gaps = 2/138 (1%) Frame = +1 Query: 112 HIIRSNQELSEEHCQYFLYQLLRGLKYIHSA-NVIHRDLKPSNLLLNANC-DLKICDFGL 285 H R+NQ + + + + YQ+ R L YIH V HRD+KP NLL+N + +K+CDFG Sbjct: 162 HYSRANQRMPIIYVKLYTYQICRALAYIHGGVGVCHRDIKPQNLLVNPHTHQVKLCDFGS 221 Query: 286 ARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHM 465 A+ + + Y+ +R+YRAPEL+ +T+Y+ ID+WS GC+ EL+ PLFPG + Sbjct: 222 AKVLVKGEPNISYICSRYYRAPELIFGATEYTTTIDIWSAGCVLAELLLGQPLFPGESGV 281 Query: 466 HQMRLITEVIGTPTDDDL 519 Q+ I +V+GTPT +++ Sbjct: 282 DQLVEIIKVLGTPTREEI 299
>KSG1_ARATH (P43288) Shaggy-related protein kinase alpha (EC 2.7.11.1)| (ASK-alpha) Length = 405 Score = 122 bits (306), Expect = 6e-28 Identities = 58/140 (41%), Positives = 89/140 (63%), Gaps = 2/140 (1%) Frame = +1 Query: 106 LHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA-NVIHRDLKPSNLLLNANC-DLKICDF 279 + H + NQ + + + + YQ+ R L YIH V HRD+KP NLL+N + +K+CDF Sbjct: 155 IKHYNKLNQRMPLIYVKLYTYQIFRALSYIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDF 214 Query: 280 GLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRD 459 G A+ + + Y+ +R+YRAPEL+ +T+Y+ AIDVWS GC+ EL+ PLFPG Sbjct: 215 GSAKVLVKGEPNISYICSRYYRAPELIFGATEYTTAIDVWSAGCVLAELLLGQPLFPGES 274 Query: 460 HMHQMRLITEVIGTPTDDDL 519 + Q+ I +V+GTPT +++ Sbjct: 275 GVDQLVEIIKVLGTPTREEI 294
>KC47_ORYSA (P29620) CDC2+/CDC28-related protein kinase R2 (EC 2.7.11.22)| Length = 424 Score = 122 bits (306), Expect = 6e-28 Identities = 62/147 (42%), Positives = 88/147 (59%), Gaps = 2/147 (1%) Frame = +1 Query: 70 DVYIATELMDTDLHHIIRS-NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLL 246 ++++ E M+TDL +IR N LS + ++ +L+GL + H V+HRD+KP+NLL+ Sbjct: 90 NLHLVFEFMETDLEAVIRDRNIVLSPADTKSYIQMMLKGLAFCHKKWVLHRDMKPNNLLI 149 Query: 247 NANCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 A+ LK+ DFGLAR S T V RWYRAPELL + Y +A+D+W+ GCIF E Sbjct: 150 GADGQLKLADFGLARIFGSPERNFTHQVFARWYRAPELLFGTKQYGSAVDIWAAGCIFAE 209 Query: 424 LINRAPLFPGRDHMHQMRLITEVIGTP 504 L+ R P G + Q+ I GTP Sbjct: 210 LLLRRPFLQGSSDIDQLGKIFAAFGTP 236
>CDKL2_MOUSE (Q9QUK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 568 Score = 122 bits (305), Expect = 8e-28 Identities = 56/143 (39%), Positives = 91/143 (63%), Gaps = 2/143 (1%) Frame = +1 Query: 76 YIATELMD-TDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNA 252 Y+ E +D T L + L + Q +L+Q++ G+ + HS N+IHRD+KP N+L++ Sbjct: 77 YLVFEFVDHTILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQ 136 Query: 253 NCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 + +K+CDFG AR ++ ++ T+YV TRWYRAPELL+ Y A+D+W++GC+ +E++ Sbjct: 137 SGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEML 196 Query: 430 NRAPLFPGRDHMHQMRLITEVIG 498 PLFPG + Q+ I +G Sbjct: 197 MGQPLFPGESDIDQLHHIMTCLG 219
>CDC2H_DICDI (P34117) CDC2-like serine/threonine-protein kinase CRP (EC| 2.7.11.22) (EC 2.7.11.23) Length = 292 Score = 122 bits (305), Expect = 8e-28 Identities = 62/144 (43%), Positives = 89/144 (61%), Gaps = 2/144 (1%) Frame = +1 Query: 88 ELMDTDLH-HIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDL 264 E +D DL ++ E+S+ + F+YQLL+G+ + H V+HRDLKP NLL+N +L Sbjct: 81 EYLDQDLKKYLDECGGEISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGEL 140 Query: 265 KICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAP 441 K+ DFGLAR + VVT WYRAP++L+ S YS ID+WS CIF E+ + P Sbjct: 141 KLADFGLARAFGIPVRTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSALCIFAEMASGRP 200 Query: 442 LFPGRDHMHQMRLITEVIGTPTDD 513 LFPG Q+ I +++GTP ++ Sbjct: 201 LFPGSGTSDQLFRIFKILGTPNEE 224
>PEF1_SCHPO (O74456) Serine/threonine-protein kinase pef1 (EC 2.7.11.22)| (Cyclin-dependent kinase pef1) (PHO85 homolog) Length = 288 Score = 122 bits (305), Expect = 8e-28 Identities = 66/155 (42%), Positives = 94/155 (60%), Gaps = 4/155 (2%) Frame = +1 Query: 58 QSFNDVYIATELMDTDLHHIIRS--NQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLK 228 Q+ N + + E M+ DL + + NQ L + F QLL+G+ + H V+HRDLK Sbjct: 69 QTENKLMLVFEYMEKDLKKYMDTYGNQGALPPSQVKNFTQQLLKGISFCHENRVLHRDLK 128 Query: 229 PSNLLLNANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSV 405 P NLL+N+ +LK+ DFGLAR + + VVT WYRAP++LL S YS +ID+WSV Sbjct: 129 PQNLLINSRGELKLADFGLARSIGIPVNTFSNEVVTLWYRAPDVLLGSRVYSTSIDIWSV 188 Query: 406 GCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 GCI E+ PLF G ++ Q+ I ++GTPT+ Sbjct: 189 GCIMAEMATGRPLFAGSNNEDQLLKIFRLLGTPTE 223
>CDKL2_RAT (Q5XIT0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 507 Score = 122 bits (305), Expect = 8e-28 Identities = 56/143 (39%), Positives = 91/143 (63%), Gaps = 2/143 (1%) Frame = +1 Query: 76 YIATELMD-TDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNA 252 Y+ E +D T L + L + Q +L+Q++ G+ + HS N+IHRD+KP N+L++ Sbjct: 77 YLVFEFVDHTILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQ 136 Query: 253 NCDLKICDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELI 429 + +K+CDFG AR ++ ++ T+YV TRWYRAPELL+ Y A+D+W++GC+ +E++ Sbjct: 137 SGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEML 196 Query: 430 NRAPLFPGRDHMHQMRLITEVIG 498 PLFPG + Q+ I +G Sbjct: 197 MGQPLFPGESDIDQLHHIMTCLG 219
>CDK4_HUMAN (P11802) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) Length = 303 Score = 121 bits (304), Expect = 1e-27 Identities = 60/127 (47%), Positives = 82/127 (64%) Frame = +1 Query: 136 LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMM 315 L E + + Q LRGL ++H+ ++HRDLKP N+L+ + +K+ DFGLAR S + Sbjct: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL 171 Query: 316 TEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVI 495 T VVT WYRAPE+LL ST Y+ +D+WSVGCIF E+ R PLF G Q+ I ++I Sbjct: 172 TPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 Query: 496 GTPTDDD 516 G P +DD Sbjct: 231 GLPPEDD 237
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 121 bits (304), Expect = 1e-27 Identities = 64/151 (42%), Positives = 89/151 (58%), Gaps = 4/151 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHI---IRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 +Y+ E + DL I S Q L + +LYQ+L+G+ + HS V+HRDLKP NLL Sbjct: 76 LYLIFEFLSMDLKKYLDTIPSGQYLDRSRVKSYLYQILQGIVFCHSRRVLHRDLKPQNLL 135 Query: 244 LNANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 ++ +K+ DFGLAR + T VVT WYR+PE+LL S YS +D+WS+G IF Sbjct: 136 IDDKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRSPEVLLGSALYSTPVDIWSIGTIFA 195 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 EL + PLF G + Q+ I +GTP +D Sbjct: 196 ELATKKPLFHGDSEIDQLFRIFRALGTPNND 226
>CDC2C_ANTMA (Q38774) Cell division control protein 2 homolog C (EC 2.7.11.22)| (EC 2.7.11.23) Length = 305 Score = 121 bits (304), Expect = 1e-27 Identities = 68/155 (43%), Positives = 96/155 (61%), Gaps = 8/155 (5%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQE------LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPS 234 +Y+ E +DTDL I S+++ L + Q FL+QL +G+ + H+ V+HRDLKP Sbjct: 83 LYLVFEYLDTDLKKFIDSHRKGPNPRPLPPQQIQSFLFQLCKGVSHCHAHGVLHRDLKPQ 142 Query: 235 NLLLNANCD-LKICDFGLARPSSES-DMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVG 408 NLLL+ + LKI D GLAR + T +VT YRAPE+LL S+ YS A+D+ SVG Sbjct: 143 NLLLDKDKGVLKIADLGLARAFTVPLKSYTHEIVTLSYRAPEVLLGSSHYSTAVDMSSVG 202 Query: 409 CIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 CIF E++ R LFPG Q+ I ++GTP+D+ Sbjct: 203 CIFAEMVRRQALFPGDSEFQQLLHIFRLLGTPSDE 237
>MDS1_YEAST (P38615) Serine/threonine-protein kinase MDS1/RIM11 (EC 2.7.11.1)| Length = 370 Score = 121 bits (304), Expect = 1e-27 Identities = 54/140 (38%), Positives = 88/140 (62%), Gaps = 2/140 (1%) Frame = +1 Query: 106 LHHIIRSNQELSEEHCQYFLYQLLRGLKYIHS-ANVIHRDLKPSNLLLNANC-DLKICDF 279 L H + +S +Y+++QL + L Y+H ANV HRD+KP NLL++ LK+CDF Sbjct: 125 LRHFVHQRTPMSRLEIKYYMFQLFKSLNYLHHFANVCHRDIKPQNLLVDPETWSLKLCDF 184 Query: 280 GLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRD 459 G A+ ++ Y+ +R+YRAPEL+ +T+Y+ ID+WS GC+ EL+ P+FPG Sbjct: 185 GSAKQLKPTEPNVSYICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGES 244 Query: 460 HMHQMRLITEVIGTPTDDDL 519 + Q+ I +++GTP+ ++ Sbjct: 245 GIDQLVEIIKILGTPSKQEI 264
>CDK4_RAT (P35426) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) Length = 303 Score = 121 bits (303), Expect = 1e-27 Identities = 60/127 (47%), Positives = 82/127 (64%) Frame = +1 Query: 136 LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMM 315 L E + + Q L GL ++H+ ++HRDLKP N+L+ +N +K+ DFGLAR S + Sbjct: 112 LPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMAL 171 Query: 316 TEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVI 495 T VVT WYRAPE+LL ST Y+ +D+WSVGCIF E+ R PLF G Q+ I ++I Sbjct: 172 TPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 Query: 496 GTPTDDD 516 G P +DD Sbjct: 231 GLPPEDD 237
>CDK4_PIG (P79432) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 303 Score = 121 bits (303), Expect = 1e-27 Identities = 60/127 (47%), Positives = 82/127 (64%) Frame = +1 Query: 136 LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMM 315 L E + + Q LRGL ++H+ ++HRDLKP N+L+ + +K+ DFGLAR S + Sbjct: 112 LPVETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL 171 Query: 316 TEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVI 495 T VVT WYRAPE+LL ST Y+ +D+WSVGCIF E+ R PLF G Q+ I ++I Sbjct: 172 TPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 Query: 496 GTPTDDD 516 G P +DD Sbjct: 231 GLPPEDD 237
>CDK4_MOUSE (P30285) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) (CRK3) Length = 303 Score = 121 bits (303), Expect = 1e-27 Identities = 60/127 (47%), Positives = 82/127 (64%) Frame = +1 Query: 136 LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDFGLARPSSESDMM 315 L E + + Q L GL ++H+ ++HRDLKP N+L+ +N +K+ DFGLAR S + Sbjct: 112 LPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMAL 171 Query: 316 TEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVI 495 T VVT WYRAPE+LL ST Y+ +D+WSVGCIF E+ R PLF G Q+ I ++I Sbjct: 172 TPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 Query: 496 GTPTDDD 516 G P +DD Sbjct: 231 GLPPEDD 237
>GSK3H_DROME (P83101) Putative glycogen synthase kinase-3 homolog (EC 2.7.11.26)| (GSK-3) (Protein gasket) Length = 501 Score = 121 bits (303), Expect = 1e-27 Identities = 57/134 (42%), Positives = 84/134 (62%), Gaps = 1/134 (0%) Frame = +1 Query: 121 RSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCD-LKICDFGLARPS 297 R+ Q L + ++YQLLR + Y+HS HRD+KP N+LL++ LK+CDFG A+ Sbjct: 125 RAKQTLPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQL 184 Query: 298 SESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMR 477 + Y+ +R+YRAPEL+ STDY+ ID+WS GC+ EL+ +FPG + Q+ Sbjct: 185 ISGEPNVSYICSRYYRAPELIFGSTDYTTKIDMWSAGCVMSELLLGQLIFPGDSGVDQIV 244 Query: 478 LITEVIGTPTDDDL 519 I +V+GTPT + L Sbjct: 245 EIVKVMGTPTSEQL 258
>KSG10_ARATH (Q39019) Shaggy-related protein kinase kappa (EC 2.7.11.1)| (ASK-kappa) (AtK-1) Length = 421 Score = 121 bits (303), Expect = 1e-27 Identities = 57/135 (42%), Positives = 90/135 (66%), Gaps = 2/135 (1%) Frame = +1 Query: 121 RSNQELSEEHCQYFLYQLLRGLKYIHSA-NVIHRDLKPSNLLLNANC-DLKICDFGLARP 294 R+NQ + + + + YQ+ R L YIH++ + HRD+KP NLL+N + LKICDFG A+ Sbjct: 174 RTNQLMPLIYVKLYTYQICRALAYIHNSFGLCHRDIKPQNLLVNPHTHQLKICDFGSAKV 233 Query: 295 SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQM 474 + + Y+ +R+YRAPEL+ +++Y+ AID+WS GC+ EL+ PLFPG + Q+ Sbjct: 234 LVKGEPNVSYICSRYYRAPELIFGASEYTTAIDIWSTGCVMAELLLGQPLFPGESGVDQL 293 Query: 475 RLITEVIGTPTDDDL 519 I +V+GTPT +++ Sbjct: 294 VEIIKVLGTPTREEI 308
>MSK1_TOBAC (Q40518) Shaggy-related protein kinase NtK-1 (EC 2.7.11.1)| Length = 409 Score = 121 bits (303), Expect = 1e-27 Identities = 60/159 (37%), Positives = 99/159 (62%), Gaps = 8/159 (5%) Frame = +1 Query: 67 NDVYI--ATELMDTDLHHIIRSNQELSEEH----CQYFLYQLLRGLKYIH-SANVIHRDL 225 ++VY+ E + +H +I+ +L++ + + YQ+ R L YIH + V HRD+ Sbjct: 140 DEVYLNLVLEYVPETVHRVIKHYNKLNQRMPLILVKLYTYQIFRALSYIHHTIGVCHRDI 199 Query: 226 KPSNLLLNANC-DLKICDFGLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWS 402 KP NLL+N + +K+CDFG A+ + + Y+ +R+YRAPEL+ +T+Y+ AID+WS Sbjct: 200 KPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISYICSRYYRAPELIFGATEYTTAIDIWS 259 Query: 403 VGCIFMELINRAPLFPGRDHMHQMRLITEVIGTPTDDDL 519 GC+ EL+ PLFPG + Q+ I +V+GTPT +++ Sbjct: 260 AGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEI 298
>CDKL1_BRARE (Q6AXJ9) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 350 Score = 120 bits (302), Expect = 2e-27 Identities = 56/134 (41%), Positives = 86/134 (64%), Gaps = 1/134 (0%) Frame = +1 Query: 100 TDLHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDF 279 T L+ + R + + E + ++Q L+ + + H N IHRD+KP N+L+ + +K+CDF Sbjct: 86 TVLNELDRYPRGVPEHMVKSIIWQTLQAVNFCHKQNCIHRDVKPENILITKHQVIKLCDF 145 Query: 280 GLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGR 456 G AR + D T+ V TRWYRAPELL+ T Y +DVW+VGC+F EL++ APL+PG+ Sbjct: 146 GFARILTGPCDYYTDCVATRWYRAPELLVGDTQYGPPVDVWAVGCVFAELLSGAPLWPGK 205 Query: 457 DHMHQMRLITEVIG 498 + Q+ LI + +G Sbjct: 206 SDVDQLYLIRKTLG 219
>CDKL5_HUMAN (O76039) Cyclin-dependent kinase-like 5 (EC 2.7.11.22)| (Serine/threonine-protein kinase 9) Length = 1030 Score = 120 bits (302), Expect = 2e-27 Identities = 59/145 (40%), Positives = 93/145 (64%), Gaps = 3/145 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHIIRSNQE-LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLN 249 +Y+ E ++ ++ ++ + E + ++YQL++ + + H +++HRD+KP NLL++ Sbjct: 85 LYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLIS 144 Query: 250 ANCDLKICDFGLARPSSESD--MMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFME 423 N LK+CDFG AR SE + TEYV TRWYR+PELLL + Y ++D+WSVGCI E Sbjct: 145 HNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA-PYGKSVDMWSVGCILGE 203 Query: 424 LINRAPLFPGRDHMHQMRLITEVIG 498 L + PLFPG + Q+ I +V+G Sbjct: 204 LSDGQPLFPGESEIDQLFTIQKVLG 228
>CRK1_LEIME (Q06309) Cell division protein kinase 2 homolog CRK1 (EC 2.7.11.23)| Length = 301 Score = 120 bits (302), Expect = 2e-27 Identities = 63/146 (43%), Positives = 86/146 (58%), Gaps = 2/146 (1%) Frame = +1 Query: 79 IATELMDTDLH-HIIRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNAN 255 I E +D DL ++ R N L Q+F+ LLRG+ + H +V+HRDLKP NLL++ Sbjct: 79 IVFEYLDLDLKKYLDRENGNLDAATIQHFMRDLLRGVAFCHQRSVLHRDLKPQNLLISRE 138 Query: 256 CDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELIN 432 +LK+ DFGL R + T VVT WYR P++LL S Y +DVWSVGCIF E+ Sbjct: 139 KELKLGDFGLGRSFAIPVRKFTNEVVTLWYRPPDVLLGSMQYGPPVDVWSVGCIFSEMAT 198 Query: 433 RAPLFPGRDHMHQMRLITEVIGTPTD 510 PLF G++ Q+ I +GTP + Sbjct: 199 GTPLFAGKNDADQLMRIFRFLGTPNN 224
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 120 bits (302), Expect = 2e-27 Identities = 64/151 (42%), Positives = 93/151 (61%), Gaps = 4/151 (2%) Frame = +1 Query: 73 VYIATELMDTDLHHI---IRSNQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLL 243 +Y+ E + DL I S Q L + +LYQ+L+G+ + H+ V+HRDLKP NLL Sbjct: 76 LYLIFEFLSMDLKKYLDSIPSGQYLEAMLVKSYLYQILQGIIFCHARRVLHRDLKPQNLL 135 Query: 244 LNANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFM 420 +++ +K+ DFGLAR + T VVT WYRAPE+LL S YS +DVWS+G IF Sbjct: 136 IDSKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSVRYSTPVDVWSIGTIFA 195 Query: 421 ELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 E+ ++ PLF G + Q+ I+E+ GTP ++ Sbjct: 196 EIASKKPLFHGDSEIDQLFRISELWGTPNNE 226
>KSGT_BRANA (O04160) Shaggy-related protein kinase theta (EC 2.7.11.1)| (ASK-theta) Length = 468 Score = 120 bits (302), Expect = 2e-27 Identities = 59/140 (42%), Positives = 87/140 (62%), Gaps = 2/140 (1%) Frame = +1 Query: 106 LHHIIRSNQELSEEHCQYFLYQLLRGLKYIHSA-NVIHRDLKPSNLLLNANC-DLKICDF 279 L H + NQ + Q + YQ+ R L Y+H V HRD+KP NLL+N + LKICDF Sbjct: 220 LKHYTKMNQHMPIILVQLYTYQICRALNYLHRVVGVCHRDIKPQNLLVNTHTHQLKICDF 279 Query: 280 GLARPSSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRD 459 G A+ + Y+ +R+YRAPEL+ +T+Y+ AID+WS GC+ EL+ PLFPG Sbjct: 280 GSAKMLVPGEPNISYICSRYYRAPELIFGATEYTNAIDMWSGGCVMAELLLGQPLFPGES 339 Query: 460 HMHQMRLITEVIGTPTDDDL 519 + Q+ I +++GTPT +++ Sbjct: 340 GIDQLVEIIKILGTPTREEI 359
>CDK10_HUMAN (Q15131) Cell division protein kinase 10 (EC 2.7.11.22)| (Serine/threonine-protein kinase PISSLRE) Length = 360 Score = 120 bits (302), Expect = 2e-27 Identities = 61/126 (48%), Positives = 83/126 (65%), Gaps = 1/126 (0%) Frame = +1 Query: 139 SEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDFGLARPSSES-DMM 315 SE + + Q+LRGL+Y+H +IHRDLK SNLL+ +K DFGLAR M Sbjct: 136 SEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPM 195 Query: 316 TEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEVI 495 T VVT WYRAPELLL +T + +ID+W+VGCI EL+ PL PG +HQ+ LI +++ Sbjct: 196 TPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLL 255 Query: 496 GTPTDD 513 GTP+++ Sbjct: 256 GTPSEN 261
>CDK7_CARAU (P51953) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (40 kDa protein kinase) (P40 MO15) (CDC2/CDK2,4-activating kinase) Length = 344 Score = 120 bits (301), Expect = 2e-27 Identities = 62/142 (43%), Positives = 91/142 (64%), Gaps = 2/142 (1%) Frame = +1 Query: 94 MDTDLHHIIRSNQ-ELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKI 270 M+TDL II+ L+ + + ++ L+GL+Y+H+ ++HRDLKP+NLLL+ N LK+ Sbjct: 93 METDLEVIIKDTSLVLTPANIKAYILMSLQGLEYMHNHWILHRDLKPNNLLLDENGVLKL 152 Query: 271 CDFGLARP-SSESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLF 447 DFGLA+ S + + T VVTRWYRAPELL + Y +D+W+VG I EL+ R P Sbjct: 153 ADFGLAKAFGSPNRVYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGSILAELLLRVPFL 212 Query: 448 PGRDHMHQMRLITEVIGTPTDD 513 G + Q+ I E +GTPT++ Sbjct: 213 AGDSDLDQLTGIFEALGTPTEE 234
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 120 bits (301), Expect = 2e-27 Identities = 63/152 (41%), Positives = 92/152 (60%), Gaps = 4/152 (2%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRSNQELSE---EHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 N + + E MD DL + + + S + + F++QLL+G+ + H V+HRDLKP N Sbjct: 77 NKLTLVFEYMDKDLKKYMEVHGQQSALDLKVVKSFMFQLLKGIMFCHDNRVLHRDLKPQN 136 Query: 238 LLLNANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCI 414 LL+N +LK+ DFGLAR + + VVT WYRAP++LL S Y+ +ID+WS GCI Sbjct: 137 LLINNKGELKLGDFGLARAFGIPFNTFSNEVVTLWYRAPDVLLGSRAYTTSIDIWSAGCI 196 Query: 415 FMELINRAPLFPGRDHMHQMRLITEVIGTPTD 510 F E+ PLFPG + Q+ I ++GTP + Sbjct: 197 FAEMCTGKPLFPGTANEDQLIKIFRLMGTPNE 228
>CDC2_AJECA (P54119) Cell division control protein 2 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent protein kinase) Length = 324 Score = 120 bits (300), Expect = 3e-27 Identities = 59/127 (46%), Positives = 81/127 (63%), Gaps = 1/127 (0%) Frame = +1 Query: 136 LSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSNLLLNANCDLKICDFGLARPSSES-DM 312 L E + F+ QL+ G++Y HS V+HRDLKP NLL++ +LK+ DFGLAR Sbjct: 120 LGEAMVKKFMAQLVEGIRYCHSHRVLHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRT 179 Query: 313 MTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCIFMELINRAPLFPGRDHMHQMRLITEV 492 T VVT WYRAPE+LL YS +D+WSVG IF E+ R PLFPG + ++ I ++ Sbjct: 180 YTHEVVTLWYRAPEILLGGRQYSTGVDMWSVGAIFAEMCTRKPLFPGDSEIDEIFKIFKL 239 Query: 493 IGTPTDD 513 +GTP ++ Sbjct: 240 LGTPDEN 246
>CDC2_DROME (P23572) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 297 Score = 119 bits (299), Expect = 4e-27 Identities = 59/153 (38%), Positives = 90/153 (58%), Gaps = 4/153 (2%) Frame = +1 Query: 67 NDVYIATELMDTDLHHIIRS---NQELSEEHCQYFLYQLLRGLKYIHSANVIHRDLKPSN 237 N +Y+ E + DL + S ++ + E + +LYQ+ + + H V+HRDLKP N Sbjct: 74 NRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQN 133 Query: 238 LLLNANCDLKICDFGLARPSS-ESDMMTEYVVTRWYRAPELLLNSTDYSAAIDVWSVGCI 414 LL++ + +K+ DFGL R + T +VT WYRAPE+LL S YS +D+WS+GCI Sbjct: 134 LLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCI 193 Query: 415 FMELINRAPLFPGRDHMHQMRLITEVIGTPTDD 513 F E+ R PLF G + Q+ + ++ TPT+D Sbjct: 194 FAEMATRKPLFQGDSEIDQLFRMFRILKTPTED 226 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 58,975,478 Number of Sequences: 219361 Number of extensions: 1048106 Number of successful extensions: 7047 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5632 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5850 length of database: 80,573,946 effective HSP length: 105 effective length of database: 57,541,041 effective search space used: 4085413911 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
