Clone Information

BLAST Search Result

Clone Name	baaln22
Clone Library Name	barley_pub

No.	Definition	Score (bits)	E Value
1	HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3	135	8e-32
2	RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (R...	130	3e-30
3	HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing...	130	3e-30
4	RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (R...	129	8e-30
5	HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing...	127	2e-29
6	RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Reg...	126	5e-29
7	RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (R...	126	5e-29
8	HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing...	125	8e-29
9	HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing...	125	1e-28
10	RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (R...	124	1e-28
11	RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (R...	124	1e-28
12	RCC2_BRARE (Q6NYE2) Protein RCC2 homolog	113	3e-25
13	RCC2_MOUSE (Q8BK67) Protein RCC2	112	1e-24
14	RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 k...	109	6e-24
15	RCC2_XENLA (Q52KW8) Protein RCC2 homolog	106	4e-23
16	GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related ...	105	1e-22
17	RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulat...	104	2e-22
18	RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator	103	4e-22
19	GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related ...	101	1e-21
20	RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator	101	1e-21
21	NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7...	95	2e-19
22	RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regula...	94	3e-19
23	NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7...	89	7e-18
24	NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7...	89	7e-18
25	NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7...	89	9e-18
26	NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7...	89	1e-17
27	RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromo...	87	4e-17
28	RCC1_XENLA (P25183) Regulator of chromosome condensation	85	1e-16
29	RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromo...	83	6e-16
30	RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromo...	83	6e-16
31	NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7...	79	7e-15
32	RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)	72	1e-12
33	MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (E...	71	2e-12
34	HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-...	71	2e-12
35	WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region ...	70	4e-12
36	WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region ...	69	7e-12
37	MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (E...	69	9e-12
38	RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 ...	64	4e-10
39	RCC1_DROME (P25171) Regulator of chromosome condensation (Chroma...	62	1e-09
40	ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)	61	3e-09
41	ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein...	60	4e-09
42	ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)	60	4e-09
43	ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein...	59	1e-08
44	RCC1_CANAL (P52499) Protein RCC1	58	2e-08
45	RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell c...	56	8e-08
46	RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-) ...	54	3e-07
47	FBX24_HUMAN (O75426) F-box only protein 24	45	1e-04
48	FBX24_MOUSE (Q9D417) F-box only protein 24	44	3e-04
49	YB9W_YEAST (P38352) F-box protein YBR280C	33	0.56
50	PWP2_SCHPO (Q9C1X1) Periodic tryptophan protein 2 homolog	32	0.96
51	HYD_DROME (P51592) Ubiquitin--protein ligase hyd (EC 6.3.2.-) (P...	32	1.6
52	HCN1_RABIT (Q9MZS1) Potassium/sodium hyperpolarization-activated...	31	2.1
53	HCN1_RAT (Q9JKB0) Potassium/sodium hyperpolarization-activated c...	31	2.1
54	HCN1_MOUSE (O88704) Potassium/sodium hyperpolarization-activated...	31	2.1
55	HCN1_HUMAN (O60741) Potassium/sodium hyperpolarization-activated...	31	2.1
56	FREM2_LYTVA (Q9GV77) Extracellular matrix protein 3 precursor (F...	31	2.8
57	VGLD_PRVRI (P07645) Protein gp50	31	2.8
58	KLPA_EMENI (P28739) Kinesin-like protein klpA	30	3.6
59	MUC_CHICK (P01875) Ig mu chain C region	30	4.8
60	LOXC_ARATH (P38418) Lipoxygenase, chloroplast precursor (EC 1.13...	30	6.2
61	PLDP1_ARATH (Q9LRZ5) Phospholipase D p1 (EC 3.1.4.4) (AtPLDp1) (...	29	8.1

>HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3|
          Length = 1050

 Score =  135 bits (340), Expect = 8e-32
 Identities = 70/186 (37%), Positives = 104/186 (55%), Gaps = 2/186 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   +WG+N +GQLGLG    S   PQ +++ EGI +  +AAG  H+ A++  G ++GWG
Sbjct: 156 GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWG 215

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
               G LGL D  DR  P  V  +   K+V ++CG  HT  ++ SG ++T+G    GQLG
Sbjct: 216 MNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG 275

Query: 361 HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMA-LTSDGKLYGWGWNKFGQVGAGDNADH 537
           H    D + P +V  L  S  +QI+ G +HT+A + S G +Y +G    GQ+G G   + 
Sbjct: 276 HDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNV 335

Query: 538 CSPAQV 555
             P+ V
Sbjct: 336 KCPSPV 341



 Score =  102 bits (253), Expect = 1e-21
 Identities = 61/185 (32%), Positives = 95/185 (51%), Gaps = 4/185 (2%)
 Frame = +1

Query: 13  LSWGRNQNGQLGLGTTEDSLL--PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWG 186
           L WG    GQ G+ T    ++  PQ        SVK +A G  H+  + EDG++Y  G  
Sbjct: 2   LCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLN 61

Query: 187 RYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHG 366
             G LG     ++  PE++ ++    ++ VACG  H++ +S  G L+++G    GQLG  
Sbjct: 62  TKGQLGHEREGNK--PEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLM 119

Query: 367 DFEDHL-VPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG-DNADHC 540
             ED + VP  ++ L   +  Q+S G  H +AL +DG+ + WG N  GQ+G G +     
Sbjct: 120 TTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 179

Query: 541 SPAQV 555
           SP +V
Sbjct: 180 SPQRV 184



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 50/146 (34%), Positives = 74/146 (50%), Gaps = 1/146 (0%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           +G    WG N  GQLGL   +D   P  ++      V  I+ G EHTA +T+ G ++ +G
Sbjct: 208 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFG 267

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTIT-VSSSGSLYTYGWSKYGQL 357
            G  G LG    ND   P +V  + G ++  +ACG +HT+  V SSG +Y +G    GQL
Sbjct: 268 AGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQL 327

Query: 358 GHGDFEDHLVPHKVEALKDSSTSQIS 435
           G G   +   P  V+    + + Q+S
Sbjct: 328 GTGHTCNVKCPSPVKGYWAAHSGQLS 353

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>RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1)
          Length = 531

 Score =  130 bits (327), Expect = 3e-30
 Identities = 68/188 (36%), Positives = 105/188 (55%), Gaps = 4/188 (2%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI---AAGAEHTAAVTEDGDIYG 174
           G   +WG N   QLG GTT   + P  +Q    + +K +   A G+ H+ A+  DG+++ 
Sbjct: 94  GVVYAWGHNGYSQLGNGTTNQGIAP--VQVCTNLLIKQVIEVACGSHHSMALAADGELFA 151

Query: 175 WGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHTITVSSSGSLYTYGWSKYG 351
           WG+   G +G G   ++  P KV++    K V+ +ACG   ++ V  SG +Y +G++  G
Sbjct: 152 WGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTSSMAVLDSGEVYGWGYNGNG 211

Query: 352 QLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNA 531
           QLG G+  + L P +V AL     +QI  G+ HT+ALT +G LY WG N +GQ+G G   
Sbjct: 212 QLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGSKN 271

Query: 532 DHCSPAQV 555
           +  SP Q+
Sbjct: 272 NLLSPTQI 279



 Score =  114 bits (286), Expect = 1e-25
 Identities = 61/182 (33%), Positives = 99/182 (54%), Gaps = 3/182 (1%)
 Frame = +1

Query: 19  WGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA-EHTAAVTEDGDIYGWGWGRYG 195
           +G N +  LG G  + +L+P+ ++A  G  +K ++ G+  H    TEDG +Y WG   Y 
Sbjct: 46  FGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSLSYGSGPHVLLTTEDGVVYAWGHNGYS 105

Query: 196 NLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDF 372
            LG G  N    P +V +    K V+ VACG  H++ +++ G L+ +G++  GQ+G G  
Sbjct: 106 QLGNGTTNQGIAPVQVCTNLLIKQVIEVACGSHHSMALAADGELFAWGYNNCGQVGSGST 165

Query: 373 EDHLVPHKV-EALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPA 549
            +   P KV   L       I+ G   +MA+   G++YGWG+N  GQ+G G+N +  +P 
Sbjct: 166 ANQPTPRKVTNCLHTKRVVNIACGQTSSMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPV 225

Query: 550 QV 555
           +V
Sbjct: 226 RV 227



 Score =  101 bits (251), Expect = 2e-21
 Identities = 54/165 (32%), Positives = 86/165 (52%), Gaps = 2/165 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTI-QAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   +WG N  GQ+G G+T +   P+ +        V  IA G   + AV + G++YGWG
Sbjct: 147 GELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTSSMAVLDSGEVYGWG 206

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
           +   G LGLG+  ++  P +V+++ G  +  + CG+ HT+ ++  G LY +G + YGQLG
Sbjct: 207 YNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266

Query: 361 HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL-TSDGKLYGWG 492
            G   + L P ++   K+      +    HT A  T  G +Y WG
Sbjct: 267 TGSKNNLLSPTQIMVEKERVIEIAACHSTHTSAAKTQGGHVYMWG 311



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 45/149 (30%), Positives = 79/149 (53%), Gaps = 2/149 (1%)
 Frame = +1

Query: 115 MIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG-WR 291
           +    A     VT++ +++ +G      LG GD     VP+K+ ++ G K+  ++ G   
Sbjct: 26  VFGTSANEAIYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSLSYGSGP 85

Query: 292 HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTS 468
           H +  +  G +Y +G + Y QLG+G     + P +V   L      +++ G  H+MAL +
Sbjct: 86  HVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEVACGSHHSMALAA 145

Query: 469 DGKLYGWGWNKFGQVGAGDNADHCSPAQV 555
           DG+L+ WG+N  GQVG+G  A+  +P +V
Sbjct: 146 DGELFAWGYNNCGQVGSGSTANQPTPRKV 174



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 42/116 (36%), Positives = 62/116 (53%), Gaps = 1/116 (0%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           +G    WG N NGQLGLG   + L P  + A  G+ V  I  G  HT A+T++G +Y WG
Sbjct: 199 SGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWG 258

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMV-LVACGWRHTITVSSSGSLYTYGWSK 345
              YG LG G +N+   P ++  VE ++++ + AC   HT    + G  + Y W +
Sbjct: 259 ANTYGQLGTGSKNNLLSPTQI-MVEKERVIEIAACHSTHTSAAKTQGG-HVYMWGQ 312



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 33/109 (30%), Positives = 51/109 (46%), Gaps = 1/109 (0%)
 Frame = +1

Query: 232 PEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALK 411
           P++  S+   K  +        I V+ +  ++ +G +    LG GD +  LVP K+EAL 
Sbjct: 15  PQEAGSIR--KACVFGTSANEAIYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEALC 72

Query: 412 DSSTSQIS-GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 555
                 +S G   H +  T DG +Y WG N + Q+G G      +P QV
Sbjct: 73  GKKIKSLSYGSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQV 121

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>HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4912

 Score =  130 bits (326), Expect = 3e-30
 Identities = 71/188 (37%), Positives = 101/188 (53%), Gaps = 4/188 (2%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA--AGAEHTAAVTEDGDIYGW 177
            G   + G   NG+LGLG T +  LP  +       VK +A  +G +H  A+T DG ++ W
Sbjct: 3038 GKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSW 3097

Query: 178  GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
            G G  G LG G+R     P  V ++   K+  VACG  H+  +SS G LYT+G  +YG+L
Sbjct: 3098 GEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRL 3157

Query: 358  GHGDFEDHLVPHKVEALKDSSTSQISGGWR--HTMALTSDGKLYGWGWNKFGQVGAGDNA 531
            GHGD    L P  V AL      Q++ G R   T+ALT DG ++ WG   FG++G G + 
Sbjct: 3158 GHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSE 3217

Query: 532  DHCSPAQV 555
               +P ++
Sbjct: 3218 GSDTPHEI 3225



 Score =  122 bits (307), Expect = 5e-28
 Identities = 63/176 (35%), Positives = 101/176 (57%), Gaps = 2/176 (1%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA--EHTAAVTEDGDIYG 174
            +G  L+WG+ + G+LG G +ED L P+ ++A  G     IA G+    T  +T+D +++ 
Sbjct: 4206 SGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWS 4265

Query: 175  WGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
            WG G YG LG G  +   +P K+ S+ G  +V V CG + ++ ++ SG++YT+G   + +
Sbjct: 4266 WGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHR 4325

Query: 355  LGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
            LGHG  +    P KV AL+      I+ G  H +A +  G++Y WG N  GQ+G G
Sbjct: 4326 LGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDG 4381



 Score =  117 bits (294), Expect = 2e-26
 Identities = 62/183 (33%), Positives = 101/183 (55%), Gaps = 4/183 (2%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA--AGAEHTAAVTEDGDIYGW 177
            G   + G    G+LG+G ++   +P  + + + + VK +A  +G +H  A+T +G++Y W
Sbjct: 4101 GKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAW 4160

Query: 178  GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
            G G  G LG G+R     P+ V  + G  +  +ACG  H+  +++SG + T+G  +YG+L
Sbjct: 4161 GEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRL 4220

Query: 358  GHGDFEDHLVPHKVEALKDSSTSQIS--GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNA 531
            GHGD ED L P  VEAL       I+   G   T+ +T D  ++ WG   +G++G G  +
Sbjct: 4221 GHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRG-GS 4279

Query: 532  DHC 540
            D C
Sbjct: 4280 DGC 4282



 Score =  113 bits (282), Expect = 4e-25
 Identities = 58/186 (31%), Positives = 96/186 (51%), Gaps = 2/186 (1%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE--HTAAVTEDGDIYGW 177
            G   +WG  + G+LG G     L P+ + A  G  V  +A G+    T A+TEDG ++ W
Sbjct: 3144 GELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSW 3203

Query: 178  GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
            G G +G LG G       P ++  + G  +V + CG + ++ ++ +G ++T+G   Y +L
Sbjct: 3204 GDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRL 3263

Query: 358  GHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADH 537
            GHG  +    P  +  L+      ++ G  H +A+T  G++Y WG N  GQ G+G+   +
Sbjct: 3264 GHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVN 3323

Query: 538  CSPAQV 555
              PA V
Sbjct: 3324 KKPALV 3329



 Score =  102 bits (255), Expect = 6e-22
 Identities = 58/187 (31%), Positives = 93/187 (49%), Gaps = 2/187 (1%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
            A     WG N  GQLG         P   +A   +    +A G +   AVT DG ++  G
Sbjct: 4048 ASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATG 4107

Query: 181  WGRYGNLGLGDRNDRFVPEKVSSVEGD--KMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
            +G  G LG+G  +   +P  + S++    K V V  G +H + +++ G +Y +G  + G+
Sbjct: 4108 YGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGK 4167

Query: 355  LGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNAD 534
            LGHG+   +  P  VE L   S + I+ G  H+ A+T+ G +  WG  ++G++G GD+ D
Sbjct: 4168 LGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSED 4227

Query: 535  HCSPAQV 555
               P  V
Sbjct: 4228 QLRPKLV 4234



 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 51/151 (33%), Positives = 85/151 (56%)
 Frame = +1

Query: 16   SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
            SWG    G+LG G ++   LP  I++  G+ V  +  G++ + A+T+ G +Y WG G + 
Sbjct: 4265 SWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFH 4324

Query: 196  NLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE 375
             LG G  +    P+KV++++G K++ +A G  H +  S SG +YT+G +  GQLG G   
Sbjct: 4325 RLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVT 4384

Query: 376  DHLVPHKVEALKDSSTSQISGGWRHTMALTS 468
                P  V AL+     +++ G  HT+AL++
Sbjct: 4385 AIQRPRLVAALQGKHIVKVTCGSAHTLALST 4415



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 55/161 (34%), Positives = 91/161 (56%), Gaps = 2/161 (1%)
 Frame = +1

Query: 16   SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
            SWG  ++ +LG G T    +P  I A E   V+ +  G  ++AA+T  G++  WG G Y 
Sbjct: 639  SWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYA 698

Query: 196  NLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSSSGSLYTYGWSKYGQLGHGD 369
             LG G+ +DR +P  V ++    +V VA G    H++ ++S G ++ +G   YG+LG+G+
Sbjct: 699  RLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGN 758

Query: 370  FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 492
                L P  VE+L      ++  G + ++AL+S+G+LY WG
Sbjct: 759  CNGSLQPILVESL--PRVQRVFAGSQFSVALSSEGQLYTWG 797



 Score = 95.9 bits (237), Expect = 7e-20
 Identities = 56/181 (30%), Positives = 91/181 (50%), Gaps = 2/181 (1%)
 Frame = +1

Query: 19   WGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGN 198
            WG N   QLG        +P   Q    +    IA G++    V++DG +Y  G G  G 
Sbjct: 2991 WGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGR 3050

Query: 199  LGLGDRNDRFVPEKVSSVEG--DKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDF 372
            LGLG  ++  +P ++  +     K V V  G +H + ++  G ++++G  + G+LGHG+ 
Sbjct: 3051 LGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNR 3110

Query: 373  EDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ 552
                 P  VEAL+      ++ G  H+ A++S G+LY WG  ++G++G GDN     P  
Sbjct: 3111 TTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKL 3170

Query: 553  V 555
            V
Sbjct: 3171 V 3171



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 45/132 (34%), Positives = 75/132 (56%), Gaps = 2/132 (1%)
 Frame = +1

Query: 136  HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSS 315
            H  A+  + + Y WG G    LG GD + R VP K++++E   +  V CG  ++  ++  
Sbjct: 627  HFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCG 686

Query: 316  GSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS--GGWRHTMALTSDGKLYGW 489
            G+L T+G   Y +LGHG+ +D  +P  V AL D     ++   G  H++ALTS+G ++ W
Sbjct: 687  GNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAW 746

Query: 490  GWNKFGQVGAGD 525
            G   +G++G G+
Sbjct: 747  GDGDYGKLGNGN 758



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 48/152 (31%), Positives = 78/152 (51%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G   SWG    G+LG G +E S  P  I+   GI V  I  GA+ + A+T  G+++ WG 
Sbjct: 3198 GAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGK 3257

Query: 184  GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGH 363
            G Y  LG G       P+ +  + G +++ VA G  H + V+ +G +Y +G + +GQ G 
Sbjct: 3258 GDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGS 3317

Query: 364  GDFEDHLVPHKVEALKDSSTSQISGGWRHTMA 459
            G+   +  P  V  L     ++++ G  H++A
Sbjct: 3318 GNTFVNKKPALVIGLDAVFVNRVACGSSHSIA 3349



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 33/105 (31%), Positives = 56/105 (53%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
            +G   +WG+    +LG G+ +    P+ + A +G  +  IA G+ H  A ++ G++Y WG
Sbjct: 4312 SGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWG 4371

Query: 181  WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSS 315
                G LG G       P  V++++G  +V V CG  HT+ +S+S
Sbjct: 4372 DNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTS 4416



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 34/100 (34%), Positives = 47/100 (47%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
            AG   +WG+    +LG G  +    PQ I    G  V  +A GA H  AVT+ G +Y WG
Sbjct: 3249 AGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWG 3308

Query: 181  WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTI 300
               +G  G G+      P  V  ++   +  VACG  H+I
Sbjct: 3309 DNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSI 3348



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 34/113 (30%), Positives = 60/113 (53%), Gaps = 2/113 (1%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G   +WG    G+LG G    SL P  +++     V+ + AG++ + A++ +G +Y WG 
Sbjct: 741  GLVFAWGDGDYGKLGNGNCNGSLQPILVESLP--RVQRVFAGSQFSVALSSEGQLYTWGK 798

Query: 184  GRYGNLGLGDRNDR--FVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYG 336
                   L +R+ +   VP  VSS++  ++V VA    H + +SSSG ++ +G
Sbjct: 799  ATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWG 851



 Score = 36.2 bits (82), Expect = 0.066
 Identities = 16/49 (32%), Positives = 25/49 (51%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAA 147
            AG   +WG N +GQ G G T  +  P  +   + + V  +A G+ H+ A
Sbjct: 3301 AGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIA 3349



 Score = 32.7 bits (73), Expect = 0.73
 Identities = 37/164 (22%), Positives = 59/164 (35%), Gaps = 16/164 (9%)
 Frame = +1

Query: 112 KMIAAGAEHTAAVTEDGD---IYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGD------- 261
           + +  G + TAA +       IY  GW       L      F  E   S  G+       
Sbjct: 514 RCLLRGGQATAASSSSAPQQRIYALGWP-----SLSKDQQGFSAEPTLSWSGESAGVPTL 568

Query: 262 ----KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQ 429
               ++  VAC     + +S  G LYT+  +K              P  +E +       
Sbjct: 569 SCRFQIKQVACCETQMLILSQEGKLYTWRLAK----------PEAEPLPMEEVAHDVFIS 618

Query: 430 ISGGW--RHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 555
           I+G    RH +A+ S+   Y WG  +  ++G GD      P ++
Sbjct: 619 IAGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKI 662

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>RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1) (Chronic lymphocytic leukemia deletion region
           gene 7 protein) (CLL deletion region gene 7 protein)
          Length = 531

 Score =  129 bits (323), Expect = 8e-30
 Identities = 67/188 (35%), Positives = 106/188 (56%), Gaps = 4/188 (2%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI---AAGAEHTAAVTEDGDIYG 174
           G   +WG N   QLG GTT   + P  +Q    + +K +   A G+ H+ A+  DG+++ 
Sbjct: 94  GVVYAWGHNGYSQLGNGTTNQGIAP--VQVCTNLLIKQVVEVACGSHHSMALAADGEVFA 151

Query: 175 WGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHTITVSSSGSLYTYGWSKYG 351
           WG+   G +G G   ++  P KV++    K V+ +ACG   ++ V  +G +Y +G++  G
Sbjct: 152 WGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNG 211

Query: 352 QLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNA 531
           QLG G+  + L P +V AL     +QI  G+ HT+ALT +G LY WG N +GQ+G G+  
Sbjct: 212 QLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKN 271

Query: 532 DHCSPAQV 555
           +  SPA +
Sbjct: 272 NLLSPAHI 279



 Score =  110 bits (274), Expect = 4e-24
 Identities = 58/182 (31%), Positives = 101/182 (55%), Gaps = 3/182 (1%)
 Frame = +1

Query: 19  WGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA-EHTAAVTEDGDIYGWGWGRYG 195
           +G N +  LG G  + +L+P+ ++   G  +K ++ G+  H    TEDG +Y WG   Y 
Sbjct: 46  FGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYS 105

Query: 196 NLGLGDRNDRFVPEKV-SSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDF 372
            LG G  N    P +V +++   ++V VACG  H++ +++ G ++ +G++  GQ+G G  
Sbjct: 106 QLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGST 165

Query: 373 EDHLVPHKV-EALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPA 549
            +   P KV   L       I+ G   +MA+  +G++YGWG+N  GQ+G G+N +  +P 
Sbjct: 166 ANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPV 225

Query: 550 QV 555
           +V
Sbjct: 226 RV 227



 Score = 99.0 bits (245), Expect = 8e-21
 Identities = 54/165 (32%), Positives = 87/165 (52%), Gaps = 2/165 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS-VKMIAAGAEHTAAVTEDGDIYGWG 180
           G   +WG N  GQ+G G+T +   P+ +     I  V  IA G   + AV ++G++YGWG
Sbjct: 147 GEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWG 206

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
           +   G LGLG+  ++  P +V+++    +  + CG+ HT+ ++  G LY +G + YGQLG
Sbjct: 207 YNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266

Query: 361 HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL-TSDGKLYGWG 492
            G+  + L P  +   K+      +    HT A  T  G +Y WG
Sbjct: 267 TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 49/164 (29%), Positives = 83/164 (50%), Gaps = 2/164 (1%)
 Frame = +1

Query: 70  LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS 249
           L PQ I +     V      A     VT++ +++ +G      LG GD     VP+K+  
Sbjct: 13  LSPQEIASIRKACV--FGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEG 70

Query: 250 VEGDKMVLVACG-WRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSST 423
           + G K+  ++ G   H +  +  G +Y +G + Y QLG+G     + P +V   L     
Sbjct: 71  LCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQV 130

Query: 424 SQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 555
            +++ G  H+MAL +DG+++ WG+N  GQVG+G  A+  +P +V
Sbjct: 131 VEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKV 174

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>HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing protein 5|
           (Cyclin-E-binding protein 1)
          Length = 1024

 Score =  127 bits (320), Expect = 2e-29
 Identities = 68/186 (36%), Positives = 101/186 (54%), Gaps = 2/186 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   +WG+N +GQLG+G    S   PQ ++   G+ +  I+AG  H+ A++  G+IY WG
Sbjct: 157 GELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWG 216

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
               G LGLG    +  P  +  ++  K+  VACG  H+  ++  G L+T+G  K+GQLG
Sbjct: 217 KNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLG 276

Query: 361 HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD-GKLYGWGWNKFGQVGAGDNADH 537
           H   ++ L P  V  L     +QI+ G  HT+A  SD GK++ +G  K GQ+G G   D 
Sbjct: 277 HNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQ 336

Query: 538 CSPAQV 555
             P  V
Sbjct: 337 LMPLPV 342



 Score = 99.0 bits (245), Expect = 8e-21
 Identities = 59/159 (37%), Positives = 90/159 (56%), Gaps = 12/159 (7%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           +G   SWG+N+ GQLGLG TE    P  I+  +   V+ +A G  H+A +T+DG ++ +G
Sbjct: 209 SGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFG 268

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTIT-VSSSGSLYTYGWSKYGQL 357
            G++G LG     +   P  V+ + G ++  +ACG  HT+  VS  G ++++G  K GQL
Sbjct: 269 AGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQL 328

Query: 358 GHGDFEDHLVPHKV-----EALK-DSSTSQ-----ISGG 441
           G+G   D L+P  V     E LK +S TS+     I+GG
Sbjct: 329 GNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGG 367



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 44/147 (29%), Positives = 77/147 (52%), Gaps = 1/147 (0%)
 Frame = +1

Query: 118 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDR-NDRFVPEKVSSVEGDKMVLVACGWRH 294
           I  G  H+ A+++ G+++ WG   +G LG+G +      P+ V  + G  +  ++ G  H
Sbjct: 143 ITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAH 202

Query: 295 TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 474
           ++ +S SG++Y++G ++ GQLG G  E    P  +E L +     ++ G  H+  LT DG
Sbjct: 203 SMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDG 262

Query: 475 KLYGWGWNKFGQVGAGDNADHCSPAQV 555
            L+ +G  K GQ+G     +   P  V
Sbjct: 263 LLFTFGAGKHGQLGHNSTQNELRPCLV 289



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 49/161 (30%), Positives = 81/161 (50%), Gaps = 1/161 (0%)
 Frame = +1

Query: 76  PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE 255
           P+ I+  + + +  +  GAEH   ++ DG  +      Y N  +  ++ RF     S ++
Sbjct: 88  PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPF-----EYDNYSM--KHLRF----ESILQ 136

Query: 256 GDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHG-DFEDHLVPHKVEALKDSSTSQI 432
             K++ + CG  H++ +S  G L+ +G + +GQLG G  F     P  VE L     +QI
Sbjct: 137 EKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQI 196

Query: 433 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 555
           S G  H+MAL+  G +Y WG N+ GQ+G G       P+ +
Sbjct: 197 SAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLI 237



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 15/54 (27%), Positives = 27/54 (50%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGD 165
           G   S+G  ++GQLG G T D L+P  ++      +K+ +  +E    +   G+
Sbjct: 315 GKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGN 368

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>RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score =  126 bits (316), Expect = 5e-29
 Identities = 61/186 (32%), Positives = 104/186 (55%), Gaps = 2/186 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   +WG N   QLG GTT   L+P  I        V  +A G+ H+  +T DG+++ WG
Sbjct: 118 GEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWG 177

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHTITVSSSGSLYTYGWSKYGQL 357
           +   G +G G   ++ +P +V+    +K+V+ +ACG   ++ V  +G +Y +G++  GQL
Sbjct: 178 YNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIACGQMCSMAVVDTGEVYVWGYNGNGQL 237

Query: 358 GHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADH 537
           G G   +   P +V AL+     +++ G+ HT+ LT +G++Y WG N +GQ+G G+ ++ 
Sbjct: 238 GLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQ 297

Query: 538 CSPAQV 555
             P  V
Sbjct: 298 SYPTPV 303



 Score =  106 bits (265), Expect = 4e-23
 Identities = 55/181 (30%), Positives = 100/181 (55%), Gaps = 3/181 (1%)
 Frame = +1

Query: 22  GRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA-EHTAAVTEDGDIYGWGWGRYGN 198
           G N +G LG+G  + ++ P+ + +  G  +  ++ G+  H    T DG+++ WG   Y  
Sbjct: 71  GTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQ 130

Query: 199 LGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE 375
           LG G  N   VP  +S+   +K V+ VACG  H++ ++S G ++ +G++  GQ+G G   
Sbjct: 131 LGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTA 190

Query: 376 DHLVPHKVE-ALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ 552
           +  +P +V   L++     I+ G   +MA+   G++Y WG+N  GQ+G G + +  +P +
Sbjct: 191 NQPIPRRVTGCLQNKVVMSIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCR 250

Query: 553 V 555
           V
Sbjct: 251 V 251



 Score =  103 bits (257), Expect = 3e-22
 Identities = 55/165 (33%), Positives = 89/165 (53%), Gaps = 2/165 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   +WG N +GQ+G G+T +  +P+ +    +   V  IA G   + AV + G++Y WG
Sbjct: 171 GEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIACGQMCSMAVVDTGEVYVWG 230

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
           +   G LGLG   ++  P +V++++G ++  VACG+ HT+ ++  G +Y +G + YGQLG
Sbjct: 231 YNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLG 290

Query: 361 HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD-GKLYGWG 492
            G+  +   P  V   KD      +    HT A  S  G +Y WG
Sbjct: 291 TGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKSQGGHVYMWG 335



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 44/115 (38%), Positives = 65/115 (56%), Gaps = 1/115 (0%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G    WG N NGQLGLG++ +   P  + A +GI V+ +A G  HT  +T++G IY WG 
Sbjct: 224 GEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGA 283

Query: 184 GRYGNLGLGDRNDRFVPEKVSSVEGDKMV-LVACGWRHTITVSSSGSLYTYGWSK 345
             YG LG G+++++  P  V  VE D+++ + AC   HT    S G  + Y W +
Sbjct: 284 NSYGQLGTGNKSNQSYPTPV-VVEKDRIIEIAACHSAHTSAAKSQGG-HVYMWGQ 336



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 21/80 (26%), Positives = 41/80 (51%), Gaps = 1/80 (1%)
 Frame = +1

Query: 322 LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS-GGWRHTMALTSDGKLYGWGWN 498
           ++  G +  G LG GD +  + P ++++L     + +S G   H +  T+DG+++ WG N
Sbjct: 67  IFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHN 126

Query: 499 KFGQVGAGDNADHCSPAQVN 558
            + Q+G G       P  ++
Sbjct: 127 AYSQLGNGTTNHGLVPCHIS 146

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>RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score =  126 bits (316), Expect = 5e-29
 Identities = 61/186 (32%), Positives = 104/186 (55%), Gaps = 2/186 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   +WG N   QLG GTT   L+P  I        V  +A G+ H+  +T DG+++ WG
Sbjct: 118 GEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWG 177

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHTITVSSSGSLYTYGWSKYGQL 357
           +   G +G G   ++ +P +V+    +K+V+ +ACG   ++ V  +G +Y +G++  GQL
Sbjct: 178 YNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWGYNGNGQL 237

Query: 358 GHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADH 537
           G G   +   P +V AL+     +++ G+ HT+ LT +G++Y WG N +GQ+G G+ ++ 
Sbjct: 238 GLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQ 297

Query: 538 CSPAQV 555
             P  V
Sbjct: 298 SYPTPV 303



 Score =  106 bits (265), Expect = 4e-23
 Identities = 55/181 (30%), Positives = 100/181 (55%), Gaps = 3/181 (1%)
 Frame = +1

Query: 22  GRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA-EHTAAVTEDGDIYGWGWGRYGN 198
           G N +G LG+G  + ++ P+ + +  G  +  ++ G+  H    T DG+++ WG   Y  
Sbjct: 71  GTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQ 130

Query: 199 LGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE 375
           LG G  N   VP  +S+   +K V+ VACG  H++ ++S G ++ +G++  GQ+G G   
Sbjct: 131 LGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTA 190

Query: 376 DHLVPHKVE-ALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ 552
           +  +P +V   L++     I+ G   +MA+   G++Y WG+N  GQ+G G + +  +P +
Sbjct: 191 NQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCR 250

Query: 553 V 555
           V
Sbjct: 251 V 251



 Score =  103 bits (257), Expect = 3e-22
 Identities = 55/165 (33%), Positives = 89/165 (53%), Gaps = 2/165 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   +WG N +GQ+G G+T +  +P+ +    +   V  IA G   + AV + G++Y WG
Sbjct: 171 GEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWG 230

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
           +   G LGLG   ++  P +V++++G ++  VACG+ HT+ ++  G +Y +G + YGQLG
Sbjct: 231 YNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLG 290

Query: 361 HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL-TSDGKLYGWG 492
            G+  +   P  V   KD      +    HT A  T  G +Y WG
Sbjct: 291 TGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWG 335



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 43/115 (37%), Positives = 65/115 (56%), Gaps = 1/115 (0%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G    WG N NGQLGLG++ +   P  + A +GI V+ +A G  HT  +T++G IY WG 
Sbjct: 224 GEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGA 283

Query: 184 GRYGNLGLGDRNDRFVPEKVSSVEGDKMV-LVACGWRHTITVSSSGSLYTYGWSK 345
             YG LG G+++++  P  V  VE D+++ + AC   HT    + G  + Y W +
Sbjct: 284 NSYGQLGTGNKSNQSYPTPV-VVEKDRIIEIAACHSAHTSAAKTQGG-HVYMWGQ 336



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 21/80 (26%), Positives = 41/80 (51%), Gaps = 1/80 (1%)
 Frame = +1

Query: 322 LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS-GGWRHTMALTSDGKLYGWGWN 498
           ++  G +  G LG GD +  + P ++++L     + +S G   H +  T+DG+++ WG N
Sbjct: 67  IFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHN 126

Query: 499 KFGQVGAGDNADHCSPAQVN 558
            + Q+G G       P  ++
Sbjct: 127 AYSQLGNGTTNHGLVPCHIS 146

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>HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4834

 Score =  125 bits (314), Expect = 8e-29
 Identities = 64/186 (34%), Positives = 104/186 (55%), Gaps = 2/186 (1%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G   SWG  ++G+LG G       P+ I++  GI V  +AAG  H+A VT  GD+Y WG 
Sbjct: 4058 GEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGK 4117

Query: 184  GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSSSGSLYTYGWSKYGQL 357
            GRYG LG  D  D+  P+ V +++G ++V +ACG     T+ ++   +++++G   YG+L
Sbjct: 4118 GRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKL 4177

Query: 358  GHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADH 537
            G G  +   VP K+++L      ++  G + ++ALT  G +Y WG   + ++G G +   
Sbjct: 4178 GRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHV 4237

Query: 538  CSPAQV 555
              P QV
Sbjct: 4238 RRPRQV 4243



 Score =  124 bits (310), Expect = 2e-28
 Identities = 64/176 (36%), Positives = 100/176 (56%), Gaps = 2/176 (1%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA--EHTAAVTEDGDIYG 174
            AG   +WG+ + G+LG   +ED L P+ ++A +G  V  IA G+    T  +T+D  ++ 
Sbjct: 4109 AGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWS 4168

Query: 175  WGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
            WG G YG LG G  +   VP K+ S+ G  +V V CG + ++ ++ SG++YT+G   Y +
Sbjct: 4169 WGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHR 4228

Query: 355  LGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
            LGHG  +    P +V+ L+      I+ G  H +  T DG++Y WG N  GQ+G G
Sbjct: 4229 LGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDG 4284



 Score =  120 bits (302), Expect = 2e-27
 Identities = 64/183 (34%), Positives = 103/183 (56%), Gaps = 4/183 (2%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA--AGAEHTAAVTEDGDIYGW 177
            G   + G    G+LG+G TE    P  +++ + + +K +A  +G +H  A++ +G++Y W
Sbjct: 4004 GKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSW 4063

Query: 178  GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
            G    G LG G+R+    P  + S+ G ++V VA G  H+  V+++G LYT+G  +YG+L
Sbjct: 4064 GEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRL 4123

Query: 358  GHGDFEDHLVPHKVEALKDSSTSQIS--GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNA 531
            GH D ED L P  VEAL+      I+   G   T+ LT D  ++ WG   +G++G G  +
Sbjct: 4124 GHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG-GS 4182

Query: 532  DHC 540
            D C
Sbjct: 4183 DGC 4185



 Score =  117 bits (294), Expect = 2e-26
 Identities = 64/179 (35%), Positives = 99/179 (55%), Gaps = 6/179 (3%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS----VKMIAAGAEHTAAVTEDGDIY 171
            G   SWG    G+LG G T     P+ I AF G      V  IA G+ ++AA+T +G++Y
Sbjct: 514  GEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELY 573

Query: 172  GWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSSSGSLYTYGWSK 345
             WG G YG LG G   D  +P  V+ ++G K++ VACG     T+ V+ +G ++++G   
Sbjct: 574  TWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGD 633

Query: 346  YGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
            YG+LG G  +    P  +E L+D    ++  G + ++ALT DG++Y WG     ++G G
Sbjct: 634  YGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHG 692



 Score =  117 bits (293), Expect = 2e-26
 Identities = 61/186 (32%), Positives = 101/186 (54%), Gaps = 2/186 (1%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G   SWG   +G+LG  +  +   P+ I+A +   ++ IA G+ H+AA+T  G++Y WG 
Sbjct: 3066 GKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGL 3125

Query: 184  GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWR--HTITVSSSGSLYTYGWSKYGQL 357
            G YG LG GD   +  P+ V  + G +++ VACG R   T+ ++  G ++++G   +G+L
Sbjct: 3126 GEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKL 3185

Query: 358  GHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADH 537
            G G  E   +P  +E L      QI  G + ++ALT  G ++ WG   + ++G G +  H
Sbjct: 3186 GRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDV-H 3244

Query: 538  CSPAQV 555
                QV
Sbjct: 3245 VRKPQV 3250



 Score =  115 bits (288), Expect = 9e-26
 Identities = 64/178 (35%), Positives = 99/178 (55%), Gaps = 5/178 (2%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSL-LPQTIQAFEGISVKMIA--AGAEHTAAVTEDGDIYG 174
            G   + G   NG+LGLG +  ++ +P+ I A     VK +A  +G  H  A+T DG ++ 
Sbjct: 3011 GKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFS 3070

Query: 175  WGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
            WG G  G LG   R +   P  + +++  ++  +ACG  H+  ++SSG LYT+G  +YG+
Sbjct: 3071 WGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGR 3130

Query: 355  LGHGDFEDHLVPHKVEALKDSSTSQISGGWR--HTMALTSDGKLYGWGWNKFGQVGAG 522
            LGHGD    L P  V+ L      Q++ G R   T+ALT +G ++ WG   FG++G G
Sbjct: 3131 LGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3188



 Score =  113 bits (283), Expect = 3e-25
 Identities = 60/190 (31%), Positives = 96/190 (50%), Gaps = 2/190 (1%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA--EHTAAVTEDGDIYGW 177
            G   +WGR   G+LG G++ED  +P  +   +G+ V  +A G+    T AVTE+G ++ W
Sbjct: 570  GELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSW 629

Query: 178  GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
            G G YG LG G  +    P+ +  ++   +V V CG + +I ++  G +Y++G     +L
Sbjct: 630  GDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRL 689

Query: 358  GHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADH 537
            GHG  E    P  +E L+      ++ G  H +ALT D +++ WG N        D   H
Sbjct: 690  GHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSN--------DQCQH 741

Query: 538  CSPAQVNFPE 567
                +V  PE
Sbjct: 742  FDTLRVTKPE 751



 Score =  108 bits (271), Expect = 8e-24
 Identities = 56/187 (29%), Positives = 94/187 (50%), Gaps = 2/187 (1%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE--HTAAVTEDGDIYG 174
            +G   +WG  + G+LG G     L P+ ++   G  V  +A G+    T A+T++G ++ 
Sbjct: 3117 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFS 3176

Query: 175  WGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
            WG G +G LG G      +P+ +  + G  +  + CG + ++ ++ SG ++T+G   Y +
Sbjct: 3177 WGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFR 3236

Query: 355  LGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNAD 534
            LGHG       P  VE L+      ++ G  H +A+T  G++Y WG N  GQ G G    
Sbjct: 3237 LGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTV 3296

Query: 535  HCSPAQV 555
            +  P  V
Sbjct: 3297 NRKPTLV 3303



 Score =  105 bits (261), Expect = 1e-22
 Identities = 57/187 (30%), Positives = 92/187 (49%), Gaps = 2/187 (1%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
            +G    WG N  GQLG        +P   +A   +    +  G +   AVT DG +Y  G
Sbjct: 3951 SGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010

Query: 181  WGRYGNLGLGDRNDRFVPEKVSSVEG--DKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
            +G  G LG+G       P  + S++    K V V  G +H + +SS G +Y++G ++ G+
Sbjct: 4011 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4070

Query: 355  LGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNAD 534
            LGHG+      P  +E+L+      ++ G  H+  +T+ G LY WG  ++G++G  D+ D
Sbjct: 4071 LGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSED 4130

Query: 535  HCSPAQV 555
               P  V
Sbjct: 4131 QLKPKLV 4137



 Score = 99.0 bits (245), Expect = 8e-21
 Identities = 58/182 (31%), Positives = 90/182 (49%), Gaps = 3/182 (1%)
 Frame = +1

Query: 19   WGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGN 198
            WG N   QLG        +P   +    ++V  +A G++   AVT +G +Y  G    G 
Sbjct: 2964 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGR 3023

Query: 199  LGLGDRNDRF-VPEKVSSVEG--DKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGD 369
            LGLG  +    +P +++++     K V V  G RH   ++  G ++++G    G+LGH  
Sbjct: 3024 LGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFS 3083

Query: 370  FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPA 549
              +   P  +EALK      I+ G  H+ ALTS G+LY WG  ++G++G GDN     P 
Sbjct: 3084 RMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPK 3143

Query: 550  QV 555
             V
Sbjct: 3144 MV 3145



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 47/148 (31%), Positives = 78/148 (52%)
 Frame = +1

Query: 16   SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
            SWG    G+LG G ++   +P  I +  G+ V  +  G++ + A+T+ G +Y WG G Y 
Sbjct: 4168 SWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYH 4227

Query: 196  NLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE 375
             LG G  +    P +V  ++G K++ +A G  H +  +  G +YT+G +  GQLG G   
Sbjct: 4228 RLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTN 4287

Query: 376  DHLVPHKVEALKDSSTSQISGGWRHTMA 459
                P  V AL+    ++++ G  HT+A
Sbjct: 4288 AIQRPRLVAALQGKKVNRVACGSAHTLA 4315



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 52/155 (33%), Positives = 82/155 (52%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G   SWG    G+LG G +E   +PQ I+   G  V  I  GA+ + A+T+ G ++ WG 
Sbjct: 3172 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231

Query: 184  GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGH 363
            G Y  LG G       P+ V  + G K+V VA G  H + V+ SG +Y +G + +GQ G+
Sbjct: 3232 GDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGN 3291

Query: 364  GDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 468
            G    +  P  V+ L+    ++++ G  H++A T+
Sbjct: 3292 GTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3326



 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 38/105 (36%), Positives = 57/105 (54%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
            +G   +WG+    +LG G+ +    P+ +Q  +G  V  IA G+ H    TEDG++Y WG
Sbjct: 4215 SGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWG 4274

Query: 181  WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSS 315
                G LG G  N    P  V++++G K+  VACG  HT+  S+S
Sbjct: 4275 DNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTS 4319



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 33/100 (33%), Positives = 49/100 (49%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
            +G   +WG+    +LG G+      PQ ++   G  +  +A GA H  AVT+ G +Y WG
Sbjct: 3223 SGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWG 3282

Query: 181  WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTI 300
               +G  G G       P  V  +EG K+  VACG  H++
Sbjct: 3283 DNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSV 3322



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 38/166 (22%), Positives = 73/166 (43%), Gaps = 6/166 (3%)
 Frame = +1

Query: 76  PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE 255
           P   +    + V  IA   +    ++ +G +Y   +           +D   P+ V  + 
Sbjct: 442 PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYN----------SDTLAPQLVQGLA 491

Query: 256 GDKMVLVAC--GWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQ 429
              +V +A      H + ++++G +Y++G    G+LGHGD      P  + A       +
Sbjct: 492 SRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGK 551

Query: 430 ----ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 555
               I+ G  ++ A+T++G+LY WG   +G++G G + D   P  V
Sbjct: 552 HVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLV 597



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 29/84 (34%), Positives = 44/84 (52%)
 Frame = +1

Query: 295  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 474
            T++   SG++Y +G +  GQLG  +     VP   EAL      Q+ GG +   A+T+DG
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADG 4004

Query: 475  KLYGWGWNKFGQVGAGDNADHCSP 546
            KLY  G+   G++G G      +P
Sbjct: 4005 KLYATGYGAGGRLGIGGTESVSTP 4028



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 19/51 (37%), Positives = 28/51 (54%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVT 153
            +G   +WG N +GQ G GTT  +  P  +Q  EG  +  +A G+ H+ A T
Sbjct: 3275 SGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3325

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>HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4836

 Score =  125 bits (313), Expect = 1e-28
 Identities = 63/186 (33%), Positives = 104/186 (55%), Gaps = 2/186 (1%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G   SWG  ++G+LG G       P+ I++  GI V  +AAG  H+A VT  GD+Y WG 
Sbjct: 4060 GEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGK 4119

Query: 184  GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSSSGSLYTYGWSKYGQL 357
            GRYG LG  D  D+  P+ V +++G +++ +ACG     T+ ++   +++++G   YG+L
Sbjct: 4120 GRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKL 4179

Query: 358  GHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADH 537
            G G  +   VP K+++L      ++  G + ++ALT  G +Y WG   + ++G G +   
Sbjct: 4180 GRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHV 4239

Query: 538  CSPAQV 555
              P QV
Sbjct: 4240 RRPRQV 4245



 Score =  123 bits (309), Expect = 3e-28
 Identities = 64/176 (36%), Positives = 100/176 (56%), Gaps = 2/176 (1%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA--EHTAAVTEDGDIYG 174
            AG   +WG+ + G+LG   +ED L P+ ++A +G  V  IA G+    T  +T+D  ++ 
Sbjct: 4111 AGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWS 4170

Query: 175  WGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
            WG G YG LG G  +   VP K+ S+ G  +V V CG + ++ ++ SG++YT+G   Y +
Sbjct: 4171 WGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHR 4230

Query: 355  LGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
            LGHG  +    P +V+ L+      I+ G  H +  T DG++Y WG N  GQ+G G
Sbjct: 4231 LGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDG 4286



 Score =  120 bits (302), Expect = 2e-27
 Identities = 64/183 (34%), Positives = 103/183 (56%), Gaps = 4/183 (2%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIA--AGAEHTAAVTEDGDIYGW 177
            G   + G    G+LG+G TE    P  +++ + + +K +A  +G +H  A++ +G++Y W
Sbjct: 4006 GKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSW 4065

Query: 178  GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
            G    G LG G+R+    P  + S+ G ++V VA G  H+  V+++G LYT+G  +YG+L
Sbjct: 4066 GEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRL 4125

Query: 358  GHGDFEDHLVPHKVEALKDSSTSQIS--GGWRHTMALTSDGKLYGWGWNKFGQVGAGDNA 531
            GH D ED L P  VEAL+      I+   G   T+ LT D  ++ WG   +G++G G  +
Sbjct: 4126 GHSDSEDQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG-GS 4184

Query: 532  DHC 540
            D C
Sbjct: 4185 DGC 4187



 Score =  117 bits (294), Expect = 2e-26
 Identities = 64/179 (35%), Positives = 99/179 (55%), Gaps = 6/179 (3%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGIS----VKMIAAGAEHTAAVTEDGDIY 171
            G   SWG    G+LG G T     P+ I AF G      V  IA G+ ++AA+T +G++Y
Sbjct: 515  GEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELY 574

Query: 172  GWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSSSGSLYTYGWSK 345
             WG G YG LG G   D  +P  V+ ++G K++ VACG     T+ V+ +G ++++G   
Sbjct: 575  TWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGD 634

Query: 346  YGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
            YG+LG G  +    P  +E L+D    ++  G + ++ALT DG++Y WG     ++G G
Sbjct: 635  YGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHG 693



 Score =  115 bits (289), Expect = 7e-26
 Identities = 61/186 (32%), Positives = 100/186 (53%), Gaps = 2/186 (1%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G   SWG   +G+LG  +  +   P+ IQA +   ++ IA G+ H+A +T  G++Y WG 
Sbjct: 3067 GKVFSWGEGDDGKLGHFSRMNCDKPRLIQALKTKRIRDIAYGSSHSAPLTSSGELYTWGL 3126

Query: 184  GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWR--HTITVSSSGSLYTYGWSKYGQL 357
            G YG LG GD   +  P+ V  + G +++ VACG R   T+ ++  G ++++G   +G+L
Sbjct: 3127 GEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKL 3186

Query: 358  GHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADH 537
            G G  E   +P  +E L      QI  G + ++ALT  G ++ WG   + ++G G +  H
Sbjct: 3187 GRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDV-H 3245

Query: 538  CSPAQV 555
                QV
Sbjct: 3246 VRKPQV 3251



 Score =  112 bits (279), Expect = 1e-24
 Identities = 64/178 (35%), Positives = 98/178 (55%), Gaps = 5/178 (2%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSL-LPQTIQAFEGISVKMIA--AGAEHTAAVTEDGDIYG 174
            G   S G   NG+LGLG +  ++ +P+ I A     VK +A  +G  H  A+T DG ++ 
Sbjct: 3012 GKVYSCGEATNGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFS 3071

Query: 175  WGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
            WG G  G LG   R +   P  + +++  ++  +A G  H+  ++SSG LYT+G  +YG+
Sbjct: 3072 WGEGDDGKLGHFSRMNCDKPRLIQALKTKRIRDIAYGSSHSAPLTSSGELYTWGLGEYGR 3131

Query: 355  LGHGDFEDHLVPHKVEALKDSSTSQISGGWR--HTMALTSDGKLYGWGWNKFGQVGAG 522
            LGHGD    L P  V+ L      Q++ G R   T+ALT +G ++ WG   FG++G G
Sbjct: 3132 LGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3189



 Score =  110 bits (275), Expect = 3e-24
 Identities = 58/190 (30%), Positives = 94/190 (49%), Gaps = 2/190 (1%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGA--EHTAAVTEDGDIYGW 177
            G   +WGR   G+LG G++ED  +P  +   +G+ V  +A G+    T AVTE+G ++ W
Sbjct: 571  GELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSW 630

Query: 178  GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
            G G YG LG G  +    P+ +  ++   ++ V CG + +I ++  G +Y++G     +L
Sbjct: 631  GDGDYGKLGRGGSDGCKTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRL 690

Query: 358  GHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADH 537
            GHG  E    P  +E L+      ++ G  H + LT D +++ WG N        D   H
Sbjct: 691  GHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLVLTEDSEVHSWGSN--------DQCQH 742

Query: 538  CSPAQVNFPE 567
                 V  PE
Sbjct: 743  FDTLGVTKPE 752



 Score =  108 bits (271), Expect = 8e-24
 Identities = 56/187 (29%), Positives = 94/187 (50%), Gaps = 2/187 (1%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAE--HTAAVTEDGDIYG 174
            +G   +WG  + G+LG G     L P+ ++   G  V  +A G+    T A+T++G ++ 
Sbjct: 3118 SGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFS 3177

Query: 175  WGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
            WG G +G LG G      +P+ +  + G  +  + CG + ++ ++ SG ++T+G   Y +
Sbjct: 3178 WGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFR 3237

Query: 355  LGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNAD 534
            LGHG       P  VE L+      ++ G  H +A+T  G++Y WG N  GQ G G    
Sbjct: 3238 LGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTV 3297

Query: 535  HCSPAQV 555
            +  P  V
Sbjct: 3298 NRKPTLV 3304



 Score =  105 bits (261), Expect = 1e-22
 Identities = 57/187 (30%), Positives = 92/187 (49%), Gaps = 2/187 (1%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
            +G    WG N  GQLG        +P   +A   +    +  G +   AVT DG +Y  G
Sbjct: 3953 SGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4012

Query: 181  WGRYGNLGLGDRNDRFVPEKVSSVEG--DKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
            +G  G LG+G       P  + S++    K V V  G +H + +SS G +Y++G ++ G+
Sbjct: 4013 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4072

Query: 355  LGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNAD 534
            LGHG+      P  +E+L+      ++ G  H+  +T+ G LY WG  ++G++G  D+ D
Sbjct: 4073 LGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSED 4132

Query: 535  HCSPAQV 555
               P  V
Sbjct: 4133 QLKPKLV 4139



 Score = 95.9 bits (237), Expect = 7e-20
 Identities = 56/182 (30%), Positives = 89/182 (48%), Gaps = 3/182 (1%)
 Frame = +1

Query: 19   WGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGN 198
            WG N   QLG        +P   +    ++V  +A G++   AVT +G +Y  G    G 
Sbjct: 2965 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYSCGEATNGR 3024

Query: 199  LGLGDRNDRF-VPEKVSSVEG--DKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGD 369
            LGLG  +    +P +++++     K V V  G RH   ++  G ++++G    G+LGH  
Sbjct: 3025 LGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFS 3084

Query: 370  FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPA 549
              +   P  ++ALK      I+ G  H+  LTS G+LY WG  ++G++G GDN     P 
Sbjct: 3085 RMNCDKPRLIQALKTKRIRDIAYGSSHSAPLTSSGELYTWGLGEYGRLGHGDNTTQLKPK 3144

Query: 550  QV 555
             V
Sbjct: 3145 MV 3146



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 47/148 (31%), Positives = 78/148 (52%)
 Frame = +1

Query: 16   SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
            SWG    G+LG G ++   +P  I +  G+ V  +  G++ + A+T+ G +Y WG G Y 
Sbjct: 4170 SWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYH 4229

Query: 196  NLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE 375
             LG G  +    P +V  ++G K++ +A G  H +  +  G +YT+G +  GQLG G   
Sbjct: 4230 RLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTN 4289

Query: 376  DHLVPHKVEALKDSSTSQISGGWRHTMA 459
                P  V AL+    ++++ G  HT+A
Sbjct: 4290 AIQRPRLVAALQGKKVNRVACGSAHTLA 4317



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 52/155 (33%), Positives = 82/155 (52%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G   SWG    G+LG G +E   +PQ I+   G  V  I  GA+ + A+T+ G ++ WG 
Sbjct: 3173 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3232

Query: 184  GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGH 363
            G Y  LG G       P+ V  + G K+V VA G  H + V+ SG +Y +G + +GQ G+
Sbjct: 3233 GDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGN 3292

Query: 364  GDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTS 468
            G    +  P  V+ L+    ++++ G  H++A T+
Sbjct: 3293 GTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3327



 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 38/105 (36%), Positives = 57/105 (54%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
            +G   +WG+    +LG G+ +    P+ +Q  +G  V  IA G+ H    TEDG++Y WG
Sbjct: 4217 SGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWG 4276

Query: 181  WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSS 315
                G LG G  N    P  V++++G K+  VACG  HT+  S+S
Sbjct: 4277 DNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTS 4321



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 33/100 (33%), Positives = 49/100 (49%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
            +G   +WG+    +LG G+      PQ ++   G  +  +A GA H  AVT+ G +Y WG
Sbjct: 3224 SGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWG 3283

Query: 181  WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTI 300
               +G  G G       P  V  +EG K+  VACG  H++
Sbjct: 3284 DNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSV 3323



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 37/166 (22%), Positives = 73/166 (43%), Gaps = 6/166 (3%)
 Frame = +1

Query: 76  PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE 255
           P   +    + V  +A   +    ++ +G +Y   +           +D   P+ V  + 
Sbjct: 443 PIQCEGLASLGVMQVACAEKRFLILSRNGRVYTQAYN----------SDMLAPQLVQGLA 492

Query: 256 GDKMVLVAC--GWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQ 429
              +V +A      H + ++++G +Y++G    G+LGHGD      P  + A       +
Sbjct: 493 SRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGK 552

Query: 430 ----ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 555
               I+ G  ++ A+T++G+LY WG   +G++G G + D   P  V
Sbjct: 553 HVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLV 598



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 29/84 (34%), Positives = 44/84 (52%)
 Frame = +1

Query: 295  TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDG 474
            T++   SG++Y +G +  GQLG  +     VP   EAL      Q+ GG +   A+T+DG
Sbjct: 3947 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADG 4006

Query: 475  KLYGWGWNKFGQVGAGDNADHCSP 546
            KLY  G+   G++G G      +P
Sbjct: 4007 KLYATGYGAGGRLGIGGTESVSTP 4030



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 19/51 (37%), Positives = 28/51 (54%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVT 153
            +G   +WG N +GQ G GTT  +  P  +Q  EG  +  +A G+ H+ A T
Sbjct: 3276 SGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3326

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>RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2)
          Length = 551

 Score =  124 bits (312), Expect = 1e-28
 Identities = 61/186 (32%), Positives = 104/186 (55%), Gaps = 2/186 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   +WG N   QLG GTT   L+P  I        V  +A G+ H+  +T DG+++ WG
Sbjct: 118 GEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWG 177

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHTITVSSSGSLYTYGWSKYGQL 357
           +   G +G G   ++ +P +V+    +K+V+ +ACG    + V  +G +Y +G++  GQL
Sbjct: 178 YNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQL 237

Query: 358 GHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADH 537
           G G+  +   P +V AL+     +++ G+ HT+ LT +G++Y WG N +GQ+G G+ ++ 
Sbjct: 238 GLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQ 297

Query: 538 CSPAQV 555
             P  V
Sbjct: 298 SYPTPV 303



 Score =  102 bits (255), Expect = 6e-22
 Identities = 55/165 (33%), Positives = 89/165 (53%), Gaps = 2/165 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   +WG N +GQ+G G+T +  +P+ +    +   V  IA G     AV + G++Y WG
Sbjct: 171 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
           +   G LGLG+  ++  P +V++++G ++  VACG+ HT+ ++  G +Y +G + YGQLG
Sbjct: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290

Query: 361 HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL-TSDGKLYGWG 492
            G+  +   P  V   KD      +    HT A  T  G +Y WG
Sbjct: 291 TGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 45/137 (32%), Positives = 75/137 (54%), Gaps = 2/137 (1%)
 Frame = +1

Query: 151 TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG-WRHTITVSSSGSLY 327
           T + +I+  G    G LGLGD      P ++ S+ G K+  ++ G   H +  ++ G ++
Sbjct: 62  TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVF 121

Query: 328 TYGWSKYGQLGHGDFEDHLVP-HKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF 504
           T+G + Y QLG+G     LVP H    L +    +++ G  H++ LTSDG+++ WG+N  
Sbjct: 122 TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181

Query: 505 GQVGAGDNADHCSPAQV 555
           GQVG+G   +   P +V
Sbjct: 182 GQVGSGSTVNQPIPRRV 198



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 42/115 (36%), Positives = 65/115 (56%), Gaps = 1/115 (0%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G    WG N NGQLGLG + +   P  + A +GI V+ +A G  HT  +T++G +Y WG 
Sbjct: 224 GEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGA 283

Query: 184 GRYGNLGLGDRNDRFVPEKVSSVEGDKMV-LVACGWRHTITVSSSGSLYTYGWSK 345
             YG LG G+++++  P  V +VE D+++ + AC   HT    + G  + Y W +
Sbjct: 284 NSYGQLGTGNKSNQSYPTPV-TVEKDRIIEIAACHSTHTSAAKTQGG-HVYMWGQ 336



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 20/80 (25%), Positives = 41/80 (51%), Gaps = 1/80 (1%)
 Frame = +1

Query: 322 LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS-GGWRHTMALTSDGKLYGWGWN 498
           ++  G +  G LG GD +  + P ++++L     + +S G   H +  T++G+++ WG N
Sbjct: 67  IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126

Query: 499 KFGQVGAGDNADHCSPAQVN 558
            + Q+G G       P  ++
Sbjct: 127 AYSQLGNGTTNHGLVPCHIS 146

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>RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like) (CHC1-L)
           (RCC1-like G exchanging factor)
          Length = 551

 Score =  124 bits (312), Expect = 1e-28
 Identities = 61/186 (32%), Positives = 104/186 (55%), Gaps = 2/186 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   +WG N   QLG GTT   L+P  I        V  +A G+ H+  +T DG+++ WG
Sbjct: 118 GEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWG 177

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHTITVSSSGSLYTYGWSKYGQL 357
           +   G +G G   ++ +P +V+    +K+V+ +ACG    + V  +G +Y +G++  GQL
Sbjct: 178 YNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQL 237

Query: 358 GHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADH 537
           G G+  +   P +V AL+     +++ G+ HT+ LT +G++Y WG N +GQ+G G+ ++ 
Sbjct: 238 GLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQ 297

Query: 538 CSPAQV 555
             P  V
Sbjct: 298 SYPTPV 303



 Score =  102 bits (255), Expect = 6e-22
 Identities = 55/165 (33%), Positives = 89/165 (53%), Gaps = 2/165 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   +WG N +GQ+G G+T +  +P+ +    +   V  IA G     AV + G++Y WG
Sbjct: 171 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
           +   G LGLG+  ++  P +V++++G ++  VACG+ HT+ ++  G +Y +G + YGQLG
Sbjct: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290

Query: 361 HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL-TSDGKLYGWG 492
            G+  +   P  V   KD      +    HT A  T  G +Y WG
Sbjct: 291 TGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWG 335



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 45/137 (32%), Positives = 75/137 (54%), Gaps = 2/137 (1%)
 Frame = +1

Query: 151 TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACG-WRHTITVSSSGSLY 327
           T + +I+  G    G LGLGD      P ++ S+ G K+  ++ G   H +  ++ G ++
Sbjct: 62  TVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVF 121

Query: 328 TYGWSKYGQLGHGDFEDHLVP-HKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF 504
           T+G + Y QLG+G     LVP H    L +    +++ G  H++ LTSDG+++ WG+N  
Sbjct: 122 TWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNS 181

Query: 505 GQVGAGDNADHCSPAQV 555
           GQVG+G   +   P +V
Sbjct: 182 GQVGSGSTVNQPIPRRV 198



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 42/115 (36%), Positives = 65/115 (56%), Gaps = 1/115 (0%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G    WG N NGQLGLG + +   P  + A +GI V+ +A G  HT  +T++G +Y WG 
Sbjct: 224 GEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGA 283

Query: 184 GRYGNLGLGDRNDRFVPEKVSSVEGDKMV-LVACGWRHTITVSSSGSLYTYGWSK 345
             YG LG G+++++  P  V +VE D+++ + AC   HT    + G  + Y W +
Sbjct: 284 NSYGQLGTGNKSNQSYPTPV-TVEKDRIIEIAACHSTHTSAAKTQGG-HVYMWGQ 336



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 20/80 (25%), Positives = 41/80 (51%), Gaps = 1/80 (1%)
 Frame = +1

Query: 322 LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQIS-GGWRHTMALTSDGKLYGWGWN 498
           ++  G +  G LG GD +  + P ++++L     + +S G   H +  T++G+++ WG N
Sbjct: 67  IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126

Query: 499 KFGQVGAGDNADHCSPAQVN 558
            + Q+G G       P  ++
Sbjct: 127 AYSQLGNGTTNHGLVPCHIS 146

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>RCC2_BRARE (Q6NYE2) Protein RCC2 homolog|
          Length = 495

 Score =  113 bits (283), Expect = 3e-25
 Identities = 65/208 (31%), Positives = 99/208 (47%), Gaps = 24/208 (11%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G   SWGRN  GQLG G T+    P+ I+      +   A G  HT A+TE+G +Y +G 
Sbjct: 142 GKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLGEEVIVAAACGRNHTLALTENGTVYTFGE 201

Query: 184 GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGH 363
            + G LG G++ D  +        G  +V VACG   ++ V   G+LY++G  +YGQLGH
Sbjct: 202 NKLGQLGQGNQTDAVLSPATIQYNGQPIVKVACGAEFSMIVDCKGNLYSFGCPEYGQLGH 261

Query: 364 G------------DFEDHLVPHKV----EALKDSS--------TSQISGGWRHTMALTSD 471
                        +F+  L+P +V    E  KD             ++ G  HT+ L S 
Sbjct: 262 NSDGKFIARAQRIEFDCELIPRRVAIFIEKTKDGQVLPVPNVVARDVACGANHTLVLDSQ 321

Query: 472 GKLYGWGWNKFGQVGAGDNADHCSPAQV 555
            +++ WG+  +G++G  +  D   P  V
Sbjct: 322 KRVFSWGFGGYGRLGHAEQKDEMVPRLV 349



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 43/161 (26%), Positives = 78/161 (48%), Gaps = 2/161 (1%)
 Frame = +1

Query: 76  PQTIQAFEGISVKMIAAG--AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS 249
           P        + V  + +G  A H+  +T +G ++ WG    G LG GD      P+ +  
Sbjct: 112 PHRYGCLSDVQVSCVVSGPCAAHSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEG 171

Query: 250 VEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQ 429
           +  + +V  ACG  HT+ ++ +G++YT+G +K GQLG G+  D ++             +
Sbjct: 172 LGEEVIVAAACGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQYNGQPIVK 231

Query: 430 ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ 552
           ++ G   +M +   G LY +G  ++GQ+G   +    + AQ
Sbjct: 232 VACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQ 272



 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 58/190 (30%), Positives = 91/190 (47%), Gaps = 27/190 (14%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLL-PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   ++G N+ GQLG G   D++L P TIQ + G  +  +A GAE +  V   G++Y +G
Sbjct: 194 GTVYTFGENKLGQLGQGNQTDAVLSPATIQ-YNGQPIVKVACGAEFSMIVDCKGNLYSFG 252

Query: 181 WGRYGNLGLGDRND------------RFVPEKVS---SVEGDKMVL---------VACGW 288
              YG LG                    +P +V+       D  VL         VACG 
Sbjct: 253 CPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVAIFIEKTKDGQVLPVPNVVARDVACGA 312

Query: 289 RHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA--LKDSSTSQISGGWRHTMAL 462
            HT+ + S   ++++G+  YG+LGH + +D +VP  V+         +QI  G++ + AL
Sbjct: 313 NHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYCGYQCSFAL 372

Query: 463 TSDGKLYGWG 492
           +  G L+ WG
Sbjct: 373 SEMGGLFFWG 382



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 40/154 (25%), Positives = 77/154 (50%), Gaps = 5/154 (3%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGTTEDSLLPQTIQAFE--GISVKMIAAGAEHTAAVTEDGDIYGWGWGR 189
           SWG    G+LG    +D ++P+ ++ F+  G     I  G + + A++E G ++ WG   
Sbjct: 326 SWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYCGYQCSFALSEMGGLFFWG--- 382

Query: 190 YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSK-YGQLGHG 366
              +    R     P+ V  + G K+  +ACG + +I V++  S  ++G S  +G+LG+G
Sbjct: 383 ---VTNTSRESTMYPKAVQDLCGWKIRSLACG-KSSIIVAADDSTISWGPSPTFGELGYG 438

Query: 367 DF--EDHLVPHKVEALKDSSTSQISGGWRHTMAL 462
           D   +      +V+ L    + Q+  G+ H++ +
Sbjct: 439 DNKPKSSTTAQEVKTLDGVYSEQVVMGYSHSLVI 472

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>RCC2_MOUSE (Q8BK67) Protein RCC2|
          Length = 520

 Score =  112 bits (279), Expect = 1e-24
 Identities = 62/208 (29%), Positives = 101/208 (48%), Gaps = 24/208 (11%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G   SWGRN+ GQLG G T+    P+ I+A    ++ + A G  HT A+T+ G ++ +G 
Sbjct: 167 GKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLALTDTGSVFAFGE 226

Query: 184 GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGH 363
            + G LGLG++ D           G  +  +ACG   ++ +   G+LY++G  +YGQLGH
Sbjct: 227 NKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGH 286

Query: 364 G------------DFEDHLVPHKV----EALKDSS--------TSQISGGWRHTMALTSD 471
                        +++  LVP +V    E  KD             ++ G  HT+ L S 
Sbjct: 287 NSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQ 346

Query: 472 GKLYGWGWNKFGQVGAGDNADHCSPAQV 555
            +++ WG+  +G++G  +  D   P  V
Sbjct: 347 KRVFSWGFGGYGRLGHAEQKDEMVPRLV 374



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 46/162 (28%), Positives = 84/162 (51%), Gaps = 3/162 (1%)
 Frame = +1

Query: 76  PQTIQAFEGISVKMIAAG--AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS 249
           P       G+ V+ + +G  A H+  +T +G ++ WG    G LG GD      P  + +
Sbjct: 137 PHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEA 196

Query: 250 VEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSS-TS 426
           +  + +VL ACG  HT+ ++ +GS++ +G +K GQLG G+  D  VP   + + +    +
Sbjct: 197 LSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTD-AVPSPAQIMYNGQPIT 255

Query: 427 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ 552
           +++ G   +M +   G LY +G  ++GQ+G   +    + AQ
Sbjct: 256 KMACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQ 297



 Score = 79.0 bits (193), Expect = 9e-15
 Identities = 52/189 (27%), Positives = 88/189 (46%), Gaps = 26/189 (13%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G   ++G N+ GQLGLG   D++       + G  +  +A GAE +  +   G++Y +G 
Sbjct: 219 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMLMDCKGNLYSFGC 278

Query: 184 GRYGNLGLG------------DRNDRFVPEKVS---SVEGDKMVL---------VACGWR 291
             YG LG              + +   VP +V+       D  +L         VACG  
Sbjct: 279 PEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN 338

Query: 292 HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA--LKDSSTSQISGGWRHTMALT 465
           HT+ + S   ++++G+  YG+LGH + +D +VP  V+         +QI  G+  + A++
Sbjct: 339 HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYAGYTCSFAVS 398

Query: 466 SDGKLYGWG 492
             G L+ WG
Sbjct: 399 EVGGLFFWG 407



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 42/127 (33%), Positives = 70/127 (55%), Gaps = 3/127 (2%)
 Frame = +1

Query: 190 YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSSSGSLYTYGWSKYGQLGH 363
           Y NLG     + + P +   + G ++  V  G    H++ +++ G L+++G ++ GQLGH
Sbjct: 127 YRNLG----QNLWGPHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGH 182

Query: 364 GDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHC- 540
           GD +    P  +EAL   +    + G  HT+ALT  G ++ +G NK GQ+G G+  D   
Sbjct: 183 GDTKRVEAPRLIEALSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVP 242

Query: 541 SPAQVNF 561
           SPAQ+ +
Sbjct: 243 SPAQIMY 249



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 42/157 (26%), Positives = 78/157 (49%), Gaps = 5/157 (3%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGTTEDSLLPQTIQAFE--GISVKMIAAGAEHTAAVTEDGDIYGWGWGR 189
           SWG    G+LG    +D ++P+ ++ F+  G     I AG   + AV+E G ++ WG   
Sbjct: 351 SWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYAGYTCSFAVSEVGGLFFWGATN 410

Query: 190 YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSK-YGQLGHG 366
                   R     P+ V  + G ++  +ACG + +I V++  S  ++G S  +G+LG+G
Sbjct: 411 TS------RESTMYPKAVQDLCGWRIRSLACG-KSSIIVAADESTISWGPSPTFGELGYG 463

Query: 367 DF--EDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 471
           D   +      +V+ L    + Q++ G+ H++ +  D
Sbjct: 464 DHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 500

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>RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like|
           protein TD-60)
          Length = 522

 Score =  109 bits (272), Expect = 6e-24
 Identities = 62/208 (29%), Positives = 98/208 (47%), Gaps = 24/208 (11%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G   SWGRN+ GQLG G T+    P+ I+      +   A G  HT A+TE G ++ +G 
Sbjct: 169 GKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGE 228

Query: 184 GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGH 363
            + G LGLG++ D           G  +  +ACG   ++ +   G+LY++G  +YGQLGH
Sbjct: 229 NKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGH 288

Query: 364 G------------DFEDHLVPHKV----EALKDSS--------TSQISGGWRHTMALTSD 471
                        +++  LVP +V    E  KD             ++ G  HT+ L S 
Sbjct: 289 NSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQ 348

Query: 472 GKLYGWGWNKFGQVGAGDNADHCSPAQV 555
            +++ WG+  +G++G  +  D   P  V
Sbjct: 349 KRVFSWGFGGYGRLGHAEQKDEMVPRLV 376



 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 45/162 (27%), Positives = 82/162 (50%), Gaps = 3/162 (1%)
 Frame = +1

Query: 76  PQTIQAFEGISVKMIAAG--AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS 249
           P       G+ V+ + +G  A H+  +T +G ++ WG    G LG GD      P  +  
Sbjct: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG 198

Query: 250 VEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSS-TS 426
           +  + +V  ACG  HT+ ++ +GS++ +G +K GQLG G+  D  VP   + + +    +
Sbjct: 199 LSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTD-AVPSPAQIMYNGQPIT 257

Query: 427 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ 552
           +++ G   +M +   G LY +G  ++GQ+G   +    + AQ
Sbjct: 258 KMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQ 299



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 53/189 (28%), Positives = 88/189 (46%), Gaps = 26/189 (13%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G   ++G N+ GQLGLG   D++       + G  +  +A GAE +  +   G++Y +G 
Sbjct: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGC 280

Query: 184 GRYGNLGLG------------DRNDRFVPEKVS---SVEGDKMVL---------VACGWR 291
             YG LG              + +   VP +V+       D  +L         VACG  
Sbjct: 281 PEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN 340

Query: 292 HTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA--LKDSSTSQISGGWRHTMALT 465
           HT+ + S   ++++G+  YG+LGH + +D +VP  V+         SQI  G+  + A++
Sbjct: 341 HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVS 400

Query: 466 SDGKLYGWG 492
             G L+ WG
Sbjct: 401 EVGGLFFWG 409



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 41/127 (32%), Positives = 68/127 (53%), Gaps = 3/127 (2%)
 Frame = +1

Query: 190 YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSSSGSLYTYGWSKYGQLGH 363
           Y NLG     + + P +   + G ++  V  G    H++ +++ G L+++G ++ GQLGH
Sbjct: 129 YRNLG----QNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGH 184

Query: 364 GDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHC- 540
           GD +    P  +E L        + G  HT+ALT  G ++ +G NK GQ+G G+  D   
Sbjct: 185 GDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVP 244

Query: 541 SPAQVNF 561
           SPAQ+ +
Sbjct: 245 SPAQIMY 251



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 42/157 (26%), Positives = 78/157 (49%), Gaps = 5/157 (3%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGTTEDSLLPQTIQAFE--GISVKMIAAGAEHTAAVTEDGDIYGWGWGR 189
           SWG    G+LG    +D ++P+ ++ F+  G     I AG   + AV+E G ++ WG   
Sbjct: 353 SWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATN 412

Query: 190 YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSK-YGQLGHG 366
                   R     P+ V  + G ++  +ACG + +I V++  S  ++G S  +G+LG+G
Sbjct: 413 TS------RESTMYPKAVQDLCGWRIRSLACG-KSSIIVAADESTISWGPSPTFGELGYG 465

Query: 367 DF--EDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 471
           D   +      +V+ L    + Q++ G+ H++ +  D
Sbjct: 466 DHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502

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>RCC2_XENLA (Q52KW8) Protein RCC2 homolog|
          Length = 513

 Score =  106 bits (265), Expect = 4e-23
 Identities = 61/208 (29%), Positives = 99/208 (47%), Gaps = 24/208 (11%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G   SWGRN  GQLG G  +   +P+ I++ +G      A G  HT A+TE+G +Y +G 
Sbjct: 160 GKLWSWGRNDKGQLGHGDIKRIDVPKLIESLKGEVFVHAACGRNHTLALTENGSVYAFGE 219

Query: 184 GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGH 363
            + G LGLG++ D           G  +  VACG   ++ +   G+LY++G  +YGQLGH
Sbjct: 220 NKMGQLGLGNKTDAVPSPAQILYNGQPITKVACGAEFSMIMDCKGNLYSFGCPEYGQLGH 279

Query: 364 G------------DFEDHLVPHK----VEALKDSS--------TSQISGGWRHTMALTSD 471
                        +++  L+  +    +E  KD             I+ G  H++ L S 
Sbjct: 280 NSDGKYIARAQRIEYDCELIARRIAIFIEKTKDGQILPVPNVVVRDIACGINHSLILDSQ 339

Query: 472 GKLYGWGWNKFGQVGAGDNADHCSPAQV 555
            +++ WG+  +G++G  +  D   P  V
Sbjct: 340 KRVFSWGFGGYGRLGHSEQRDEMVPRLV 367



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 51/162 (31%), Positives = 88/162 (54%), Gaps = 3/162 (1%)
 Frame = +1

Query: 76  PQTIQAFEGISVKMIAAG--AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS 249
           P       G+ V+ +A+G  A H+  +T +G ++ WG    G LG GD     VP+ + S
Sbjct: 130 PHRYGCLTGVQVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPKLIES 189

Query: 250 VEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSS-TS 426
           ++G+  V  ACG  HT+ ++ +GS+Y +G +K GQLG G+  D  VP   + L +    +
Sbjct: 190 LKGEVFVHAACGRNHTLALTENGSVYAFGENKMGQLGLGNKTD-AVPSPAQILYNGQPIT 248

Query: 427 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQ 552
           +++ G   +M +   G LY +G  ++GQ+G   +  + + AQ
Sbjct: 249 KVACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQ 290



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 45/125 (36%), Positives = 70/125 (56%), Gaps = 3/125 (2%)
 Frame = +1

Query: 190 YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGW--RHTITVSSSGSLYTYGWSKYGQLGH 363
           Y NLG     + + P +   + G ++  VA G    H++ ++  G L+++G +  GQLGH
Sbjct: 120 YRNLG----QNLWGPHRYGCLTGVQVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGH 175

Query: 364 GDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHC- 540
           GD +   VP  +E+LK       + G  HT+ALT +G +Y +G NK GQ+G G+  D   
Sbjct: 176 GDIKRIDVPKLIESLKGEVFVHAACGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVP 235

Query: 541 SPAQV 555
           SPAQ+
Sbjct: 236 SPAQI 240



 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 48/191 (25%), Positives = 84/191 (43%), Gaps = 28/191 (14%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G   ++G N+ GQLGLG   D++       + G  +  +A GAE +  +   G++Y +G 
Sbjct: 212 GSVYAFGENKMGQLGLGNKTDAVPSPAQILYNGQPITKVACGAEFSMIMDCKGNLYSFGC 271

Query: 184 GRYGNLGLGDRNDRFVPEKVSSVEGDKMVL--------------------------VACG 285
             YG LG    +D     +   +E D  ++                          +ACG
Sbjct: 272 PEYGQLG--HNSDGKYIARAQRIEYDCELIARRIAIFIEKTKDGQILPVPNVVVRDIACG 329

Query: 286 WRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEA--LKDSSTSQISGGWRHTMA 459
             H++ + S   ++++G+  YG+LGH +  D +VP  V+         +QI  G   + A
Sbjct: 330 INHSLILDSQKRVFSWGFGGYGRLGHSEQRDEMVPRLVKLFDFPGRGAAQIYAGATCSFA 389

Query: 460 LTSDGKLYGWG 492
           ++  G L+ WG
Sbjct: 390 VSEMGGLFFWG 400



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 45/157 (28%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGTTEDSLLPQTIQAFE--GISVKMIAAGAEHTAAVTEDGDIYGWGWGR 189
           SWG    G+LG     D ++P+ ++ F+  G     I AGA  + AV+E G ++ WG   
Sbjct: 344 SWGFGGYGRLGHSEQRDEMVPRLVKLFDFPGRGAAQIYAGATCSFAVSEMGGLFFWGATN 403

Query: 190 YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSK-YGQLGHG 366
                   R+    P+ V  + G K+  +ACG + +I V++  S  ++G S  +G+LG+G
Sbjct: 404 TS------RDSTMYPKAVQDLCGWKVRSLACG-KSSIIVAADESTISWGPSPTFGELGYG 456

Query: 367 D--FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSD 471
           D   +      +V+ L    + Q+  G  HT+ +  D
Sbjct: 457 DNKAKSSTTAQEVKTLDGIYSDQVIMGNSHTLVVARD 493

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>GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 458

 Score =  105 bits (261), Expect = 1e-22
 Identities = 67/169 (39%), Positives = 93/169 (55%), Gaps = 5/169 (2%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAF-EGISVKMIAAGAEHTAAVTEDGDIYGW 177
           A    +WG N  GQLGLG  ED LLPQ +  F +  SV+ I  G  H+A VT+ GD++  
Sbjct: 14  AAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVC 73

Query: 178 GWGRYGNLGLGDRND--RFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYG 351
           G  + G LGLG   D   F P K  S+ G  +  VACGW  TI ++ +G + + G + +G
Sbjct: 74  GLNKDGQLGLGHTEDIPYFTPCK--SLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFG 131

Query: 352 QLG--HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 492
           QLG  HG     +VP  +E  K+     I+ G RH +A T+ G ++ WG
Sbjct: 132 QLGVPHGP-RRCVVPQAIELHKEKVVC-IAAGLRHAVAATASGIVFQWG 178



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 53/171 (30%), Positives = 87/171 (50%), Gaps = 7/171 (4%)
 Frame = +1

Query: 22  GRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNL 201
           G N++GQLGLG TED       ++  G  ++ +A G + T  +TE+G +   G   +G L
Sbjct: 74  GLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQL 133

Query: 202 GLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGW---SKYGQLGHGD- 369
           G+     R V  +   +  +K+V +A G RH +  ++SG ++ +G    S   +L  G  
Sbjct: 134 GVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQT 193

Query: 370 ---FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQV 513
              F     P +V  L++S    +  G  H+ +LT  G++Y WG NK GQ+
Sbjct: 194 LPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQL 244



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 47/178 (26%), Positives = 87/178 (48%), Gaps = 18/178 (10%)
 Frame = +1

Query: 76  PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS-- 249
           P  +   E      + AG++H+A++T+ G++Y WG  ++G L   +     VP+K+ +  
Sbjct: 203 PSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA-NEAAFLPVPQKIEAHC 261

Query: 250 VEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHG---------DFEDHLVP--HK 396
            + +K+  +  GW H +  + +G ++T+G + YGQLG           + +D  +P    
Sbjct: 262 FQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRP 321

Query: 397 VEALKDS-----STSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 555
             ++  S       +++S G  H +A+   G  Y WGWN+ G  G G  A+  +P  V
Sbjct: 322 PNSMPSSPHCLTGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPV 378



 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 40/126 (31%), Positives = 63/126 (50%), Gaps = 1/126 (0%)
 Frame = +1

Query: 166 IYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHTITVSSSGSLYTYGWS 342
           ++ WG   YG LGLG + D  +P++++     + V  +  G  H+  V+  G L+  G +
Sbjct: 17  LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76

Query: 343 KYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
           K GQLG G  ED       ++L      Q++ GW  T+ LT +G++   G N FGQ+G  
Sbjct: 77  KDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVP 136

Query: 523 DNADHC 540
                C
Sbjct: 137 HGPRRC 142



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 55/174 (31%), Positives = 81/174 (46%), Gaps = 20/174 (11%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLL--PQTIQA--FEGISVKMIAAGAEHTAAVTEDGDI 168
           AG    WG N++GQL     E + L  PQ I+A  F+   V  I +G  H  A TE G +
Sbjct: 230 AGEVYVWGSNKHGQL---ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKM 286

Query: 169 YGWGWGRYGNLGLG---------DRNDRFVP--EKVSSVEGDKMVL-----VACGWRHTI 300
           + WG   YG LG           ++ D F+P     +S+      L     V+CG  H +
Sbjct: 287 FTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNL 346

Query: 301 TVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 462
            +   G  Y++GW+++G  G G   +   P  V+AL  SS   +  G  H++AL
Sbjct: 347 AI-IGGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLAL 399



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 29/76 (38%), Positives = 45/76 (59%), Gaps = 1/76 (1%)
 Frame = +1

Query: 310 SSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTSDGKLYG 486
           ++ +L+ +G + YGQLG G  ED L+P ++ +  K  S  +I+GG  H+  +T  G L+ 
Sbjct: 13  AAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFV 72

Query: 487 WGWNKFGQVGAGDNAD 534
            G NK GQ+G G   D
Sbjct: 73  CGLNKDGQLGLGHTED 88



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 44/183 (24%), Positives = 68/183 (37%), Gaps = 18/183 (9%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLG--LGTTE-------DSLLP---------QTIQAFEGISVKMIAAG 129
           G   +WGR   GQLG  L T E       DS LP          +     G +   ++ G
Sbjct: 284 GKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATE--VSCG 341

Query: 130 AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVS 309
           +EH  A+   G  Y WGW  +G  G G   + + P+ V ++     +LV CG  H++ + 
Sbjct: 342 SEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALC 400

Query: 310 SSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGW 489
              +        +  L       +L P  +E  +          W+   + TS      W
Sbjct: 401 QLPA--------HPALVQDPKVTYLSPDAIEDTESQKAMDKERNWKERQSETSTQSQSDW 452

Query: 490 GWN 498
             N
Sbjct: 453 SRN 455



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 12/27 (44%), Positives = 16/27 (59%)
 Frame = +1

Query: 478 LYGWGWNKFGQVGAGDNADHCSPAQVN 558
           L+ WG N +GQ+G G   D   P Q+N
Sbjct: 17  LFAWGANSYGQLGLGHKEDVLLPQQLN 43

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>RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulator (mRpgr)|
          Length = 1001

 Score =  104 bits (259), Expect = 2e-22
 Identities = 54/147 (36%), Positives = 83/147 (56%), Gaps = 1/147 (0%)
 Frame = +1

Query: 118 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 297
           ++ G EHTA VT +  +Y +G   +G LGLG +     P  + +++ +K+ L ACG  HT
Sbjct: 40  LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHT 99

Query: 298 ITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSST-SQISGGWRHTMALTSDG 474
           +  + +G +Y  G +  GQLG GD +D    H++     + T  Q+S G   + ALT DG
Sbjct: 100 LVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDG 159

Query: 475 KLYGWGWNKFGQVGAGDNADHCSPAQV 555
           KL+ WG N  GQ+G  D ++ C P +V
Sbjct: 160 KLFMWGDNSEGQIGLEDKSNVCIPHEV 186



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 59/176 (33%), Positives = 99/176 (56%), Gaps = 3/176 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTED-SLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   + G N  GQLGLG T+D     Q +      ++K ++AGA  +AA+TEDG ++ WG
Sbjct: 106 GGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWG 165

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
               G +GL D+++  +P +V+   G  +  ++CG+ H+  V+  G LYT+G  + G+LG
Sbjct: 166 DNSEGQIGLEDKSNVCIPHEVT--VGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLG 223

Query: 361 HGD--FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
             +    +H  P +V  + +    Q++ G  HT+ LT +  +Y +G  +FGQ+G G
Sbjct: 224 LPNELLMNHRSPQRVLGIPE-RVIQVACGGGHTVVLT-EKVVYAFGLGQFGQLGLG 277



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 59/177 (33%), Positives = 92/177 (51%), Gaps = 4/177 (2%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G    WG N  GQ+GL    +  +P  +    G  +  I+ G  H+A VT DG++Y +G 
Sbjct: 159 GKLFMWGDNSEGQIGLEDKSNVCIPHEVTV--GKPISWISCGYYHSAFVTMDGELYTFGE 216

Query: 184 GRYGNLGLGDR---NDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
              G LGL +    N R  P++V  +  ++++ VACG  HT+ ++    +Y +G  ++GQ
Sbjct: 217 PENGKLGLPNELLMNHRS-PQRVLGIP-ERVIQVACGGGHTVVLTEK-VVYAFGLGQFGQ 273

Query: 355 LGHGDFE-DHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
           LG G F  +   P  +E +KD     IS G  HT  +T  G LY +G  + G++G G
Sbjct: 274 LGLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKLGLG 330



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 60/182 (32%), Positives = 94/182 (51%), Gaps = 3/182 (1%)
 Frame = +1

Query: 19  WGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGN 198
           +G N  GQLGLG+    + P  I+A +   VK+ A G  HT   T+ G +Y  G    G 
Sbjct: 59  FGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQ 118

Query: 199 LGLGDRNDR-FVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE 375
           LGLGD +DR    + V     D +  ++ G   +  ++  G L+ +G +  GQ+G  D  
Sbjct: 119 LGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKS 178

Query: 376 DHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDN--ADHCSPA 549
           +  +PH+V   K    S IS G+ H+  +T DG+LY +G  + G++G  +    +H SP 
Sbjct: 179 NVCIPHEVTVGK--PISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSPQ 236

Query: 550 QV 555
           +V
Sbjct: 237 RV 238



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 41/144 (28%), Positives = 67/144 (46%)
 Frame = +1

Query: 130 AEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVS 309
           AE  + V + G ++ +G  ++            +P K    + D  + ++CG  HT  V+
Sbjct: 2   AESESLVPDTGAVFTFGKTKFAEN---------IPSKFW-FKNDIPICLSCGDEHTAIVT 51

Query: 310 SSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGW 489
            +  LY +G + +GQLG G     + P  ++ALK       + G  HT+  T  G +Y  
Sbjct: 52  GNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVSTDTGGVYAA 111

Query: 490 GWNKFGQVGAGDNADHCSPAQVNF 561
           G N  GQ+G GD  D  +  Q+ F
Sbjct: 112 GGNNEGQLGLGDTDDRDTFHQIVF 135



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 3/129 (2%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRY 192
           ++G  Q GQLGLGT   ++  P+ I+  +   +  I+ G  HTA +TE G +Y +G GR+
Sbjct: 265 AFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRH 324

Query: 193 GNLGLGDRN--DRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHG 366
           G LGLG  N  ++F P   S+     + L+ACG  H         +  +   + G +   
Sbjct: 325 GKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGGCH---------MLVFATPRLGTIDEP 375

Query: 367 DFEDHLVPH 393
            FED   P+
Sbjct: 376 KFEDVYEPY 384

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>RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1020

 Score =  103 bits (256), Expect = 4e-22
 Identities = 63/176 (35%), Positives = 97/176 (55%), Gaps = 3/176 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G    WG N  GQ+GL    +  +PQ  Q   G  V  I+ G  H+A VT DG++Y +G 
Sbjct: 159 GRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVFGE 216

Query: 184 GRYGNLGLGDR--NDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
              G LGL ++   +   P+ VS +  +K++ VACG  HT+ V +  ++YT+G  ++GQL
Sbjct: 217 PENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTV-VLTENAVYTFGLGQFGQL 274

Query: 358 GHGDF-EDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
           G G F  +   P  +E ++D + S IS G  HT  +T  G +Y +G  + G++G G
Sbjct: 275 GLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLG 330



 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 52/147 (35%), Positives = 82/147 (55%), Gaps = 1/147 (0%)
 Frame = +1

Query: 118 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 297
           ++ G EH+A VT +  +Y +G   +G LGLG ++    P  V +++ +K+ L ACG  HT
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99

Query: 298 ITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEAL-KDSSTSQISGGWRHTMALTSDG 474
           +  +  G++Y  G +  GQLG GD E+    H +     +    Q+S G   + ALT DG
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159

Query: 475 KLYGWGWNKFGQVGAGDNADHCSPAQV 555
           +L+ WG N  GQ+G  + ++ C P QV
Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVCVPQQV 186



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 58/176 (32%), Positives = 97/176 (55%), Gaps = 3/176 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG-ISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   + G N  GQLGLG TE+      I  F     +K ++AG+  +AA+TEDG ++ WG
Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
               G +GL + ++  VP++V+   G  +  ++CG+ H+  V++ G LY +G  + G+LG
Sbjct: 166 DNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLG 223

Query: 361 HGD--FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
             +    +H  P  V  + +    Q++ G  HT+ LT +  +Y +G  +FGQ+G G
Sbjct: 224 LPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLG 277



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 57/183 (31%), Positives = 94/183 (51%), Gaps = 3/183 (1%)
 Frame = +1

Query: 19  WGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGN 198
           +G N  GQLGLG+      P  ++A +   VK+ A G  HT   TE G++Y  G    G 
Sbjct: 59  FGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQ 118

Query: 199 LGLGDRNDRFVPEKVSSVEGD-KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE 375
           LGLGD  +R     +S    + K+  ++ G   +  ++  G L+ +G +  GQ+G  +  
Sbjct: 119 LGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVS 178

Query: 376 DHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDN--ADHCSPA 549
           +  VP +V   K    S IS G+ H+  +T+DG+LY +G  + G++G  +    +H +P 
Sbjct: 179 NVCVPQQVTIGK--PVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQ 236

Query: 550 QVN 558
            V+
Sbjct: 237 LVS 239



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 41/134 (30%), Positives = 71/134 (52%), Gaps = 5/134 (3%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTT--EDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGW 177
           G    +G  +NG+LGL      +   PQ +       V  +A G EHT  +TE+  +Y +
Sbjct: 209 GELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLTENA-VYTF 266

Query: 178 GWGRYGNLGLGD-RNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
           G G++G LGLG    +   P+ + ++    +  ++CG  HT  ++  G +YT+G  ++G+
Sbjct: 267 GLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGK 326

Query: 355 LGHG--DFEDHLVP 390
           LG G  +F +H +P
Sbjct: 327 LGLGLENFTNHFIP 340



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 37/102 (36%), Positives = 58/102 (56%), Gaps = 3/102 (2%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRY 192
           ++G  Q GQLGLGT   ++  P+ I+     ++  I+ G  HTA +T+ G +Y +G GR+
Sbjct: 265 TFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRH 324

Query: 193 GNLGLGDRN--DRFVPEKVSSVEGDKMVLVACGWRHTITVSS 312
           G LGLG  N  + F+P   S+     + LVACG  H +  ++
Sbjct: 325 GKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAA 366



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 32/94 (34%), Positives = 47/94 (50%)
 Frame = +1

Query: 253 EGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI 432
           + D  V ++CG  H+  V+ +  LY +G + +GQLG G       P  V+ALK       
Sbjct: 33  KNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLA 92

Query: 433 SGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNAD 534
           + G  HT+  T  G +Y  G N  GQ+G GD  +
Sbjct: 93  ACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEE 126



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 24/81 (29%), Positives = 39/81 (48%)
 Frame = +1

Query: 313 SGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 492
           SG+++T+G SK+ +   G F            K+     +S G  H+  +T + KLY +G
Sbjct: 11  SGAVFTFGKSKFAENNPGKFW----------FKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60

Query: 493 WNKFGQVGAGDNADHCSPAQV 555
            N +GQ+G G  +    P  V
Sbjct: 61  SNNWGQLGLGSKSAISKPTCV 81

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>GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 464

 Score =  101 bits (252), Expect = 1e-21
 Identities = 58/167 (34%), Positives = 87/167 (52%), Gaps = 3/167 (1%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAF-EGISVKMIAAGAEHTAAVTEDGDIYGW 177
           A    +WG N  GQLGLG  ED  LPQ +  F +   +K +  G  H+A VT+ GD++  
Sbjct: 14  AAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDLFVC 73

Query: 178 GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
           G  + G LGLG   +         + G  +  VACGW  TI ++  G + + G + +GQL
Sbjct: 74  GLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQL 133

Query: 358 G--HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 492
           G  HG     +VP  +E L++     ++ G RH +A T+ G ++ WG
Sbjct: 134 GVPHGP-RKCVVPQAIECLREKVVC-VAAGLRHALATTATGSVFQWG 178



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 54/173 (31%), Positives = 87/173 (50%), Gaps = 7/173 (4%)
 Frame = +1

Query: 22  GRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNL 201
           G N++GQLGLG TE+ L     +   G  ++ +A G + T  +TE G +   G   +G L
Sbjct: 74  GLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQL 133

Query: 202 GLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGW---SKYGQLGHGD- 369
           G+     + V  +      +K+V VA G RH +  +++GS++ +G    S   +L  G  
Sbjct: 134 GVPHGPRKCVVPQAIECLREKVVCVAAGLRHALATTATGSVFQWGTGLASSGRRLCPGQN 193

Query: 370 ---FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGA 519
              F     P +V  L++S+      G  H+ +LT  G+LY WG NK GQ+ +
Sbjct: 194 LPLFLTAKEPSRVTGLENSTAVCAVAGSDHSASLTDTGELYVWGRNKHGQLAS 246



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 48/184 (26%), Positives = 85/184 (46%), Gaps = 24/184 (13%)
 Frame = +1

Query: 76  PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFV----PEKV 243
           P  +   E  +     AG++H+A++T+ G++Y WG  ++G L       R V    P+++
Sbjct: 203 PSRVTGLENSTAVCAVAGSDHSASLTDTGELYVWGRNKHGQLA-----SRAVFLPLPQRI 257

Query: 244 SS--VEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHG----------------- 366
            +   + +K+  V  GW H +  + +G ++T+G + YGQLG                   
Sbjct: 258 EAHYFQDEKVTAVWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLA 317

Query: 367 -DFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCS 543
                + VP  +  L  +  ++IS G  H +A+  D K   WGWN+ G  G G  ++  +
Sbjct: 318 FQGPQNSVPSPLHCL--TGATEISCGSEHNLAVIRD-KCCSWGWNEHGMCGDGTESNVWT 374

Query: 544 PAQV 555
           P  V
Sbjct: 375 PTPV 378



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 42/126 (33%), Positives = 64/126 (50%), Gaps = 1/126 (0%)
 Frame = +1

Query: 166 IYGWGWGRYGNLGLGDRNDRFVPEKVSSV-EGDKMVLVACGWRHTITVSSSGSLYTYGWS 342
           ++ WG   YG LGLG + D F+P+++S   +   +  V  G  H+  V+  G L+  G +
Sbjct: 17  LFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDLFVCGLN 76

Query: 343 KYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
           K GQLG G  E+ L     + L+     Q++ GW  T+ LT  G++   G N FGQ+G  
Sbjct: 77  KDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVP 136

Query: 523 DNADHC 540
                C
Sbjct: 137 HGPRKC 142



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 49/177 (27%), Positives = 73/177 (41%), Gaps = 24/177 (13%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA--FEGISVKMIAAGAEHTAAVTEDGDIYGW 177
           G    WGRN++GQL         LPQ I+A  F+   V  + +G  H  A TE G ++ W
Sbjct: 231 GELYVWGRNKHGQLA-SRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHLVAKTETGKVFTW 289

Query: 178 GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL--------------------VACGWRHT 297
           G   YG LG         PE    VE D  +                     ++CG  H 
Sbjct: 290 GRADYGQLG----RRLEPPEAQKPVEQDSSLAFQGPQNSVPSPLHCLTGATEISCGSEHN 345

Query: 298 ITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS--QISGGWRHTMAL 462
           + V       ++GW+++G  G G   +   P  V+AL  S +    +  G  H++A+
Sbjct: 346 LAVIRD-KCCSWGWNEHGMCGDGTESNVWTPTPVQALPPSPSRLLLVGCGAGHSLAV 401



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 27/75 (36%), Positives = 43/75 (57%), Gaps = 1/75 (1%)
 Frame = +1

Query: 301 TVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKV-EALKDSSTSQISGGWRHTMALTSDGK 477
           TVS++  L+ +G + YGQLG G  ED  +P ++ +  +      ++GG  H+  +T  G 
Sbjct: 10  TVSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGD 69

Query: 478 LYGWGWNKFGQVGAG 522
           L+  G NK GQ+G G
Sbjct: 70  LFVCGLNKDGQLGLG 84



 Score = 30.8 bits (68), Expect = 2.8
 Identities = 16/49 (32%), Positives = 25/49 (51%), Gaps = 2/49 (4%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGTTEDSLLPQTIQAF--EGISVKMIAAGAEHTAAVTE 156
           SWG N++G  G GT  +   P  +QA       + ++  GA H+ AV +
Sbjct: 355 SWGWNEHGMCGDGTESNVWTPTPVQALPPSPSRLLLVGCGAGHSLAVCQ 403

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>RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1003

 Score =  101 bits (252), Expect = 1e-21
 Identities = 63/177 (35%), Positives = 97/177 (54%), Gaps = 4/177 (2%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G    WG N  GQ+GL    +  +PQ +    G  +  I+ G  H+A VT +G +Y +G 
Sbjct: 159 GELFMWGDNSEGQIGLENVTNVCVPQQVTV--GKPISWISCGYYHSAFVTTEGQLYTFGE 216

Query: 184 GRYGNLGLGDR---NDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
              G LGL ++   N R +P+ V  + G K+V VACG  HT+ ++   ++YT+G  ++GQ
Sbjct: 217 PECGKLGLPNQLLVNHR-MPQPVPGIPG-KVVQVACGGGHTVVLTEK-AVYTFGLGQFGQ 273

Query: 355 LGHGDFE-DHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
           LG G F  +  VP  +E +KD   S I+ G  HT  +T  G +Y +G  + G++G G
Sbjct: 274 LGLGTFLFETSVPKAIEHIKDQKISFIACGENHTALITDMGLMYTFGDGRHGKLGLG 330



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 52/147 (35%), Positives = 78/147 (53%), Gaps = 1/147 (0%)
 Frame = +1

Query: 118 IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 297
           ++ G EHTA VT +  +Y +G   +G LGLG ++    P  V +++ +K+   ACG  HT
Sbjct: 40  LSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRNHT 99

Query: 298 ITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEAL-KDSSTSQISGGWRHTMALTSDG 474
           +  +  G +Y  G +  GQLG GD E+    H +          Q+S G   + ALT DG
Sbjct: 100 LVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTEDG 159

Query: 475 KLYGWGWNKFGQVGAGDNADHCSPAQV 555
           +L+ WG N  GQ+G  +  + C P QV
Sbjct: 160 ELFMWGDNSEGQIGLENVTNVCVPQQV 186



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 59/176 (33%), Positives = 98/176 (55%), Gaps = 3/176 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG-ISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   + G N  GQLGLG TE+      I  F     +K ++AG+  +AA+TEDG+++ WG
Sbjct: 106 GKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTEDGELFMWG 165

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
               G +GL +  +  VP++V+   G  +  ++CG+ H+  V++ G LYT+G  + G+LG
Sbjct: 166 DNSEGQIGLENVTNVCVPQQVT--VGKPISWISCGYYHSAFVTTEGQLYTFGEPECGKLG 223

Query: 361 HGD--FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
             +    +H +P  V  +      Q++ G  HT+ LT +  +Y +G  +FGQ+G G
Sbjct: 224 LPNQLLVNHRMPQPVPGI-PGKVVQVACGGGHTVVLT-EKAVYTFGLGQFGQLGLG 277



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 53/167 (31%), Positives = 84/167 (50%), Gaps = 1/167 (0%)
 Frame = +1

Query: 19  WGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGN 198
           +G N  GQLGLG+      P  ++A +   VK  A G  HT   TE G +Y  G    G 
Sbjct: 59  FGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRNHTLVSTEGGKVYAAGGNNEGQ 118

Query: 199 LGLGDRNDRFVPEKVSSVEGD-KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE 375
           LGLGD  +R     +S      K+  ++ G   +  ++  G L+ +G +  GQ+G  +  
Sbjct: 119 LGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLENVT 178

Query: 376 DHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVG 516
           +  VP +V   K    S IS G+ H+  +T++G+LY +G  + G++G
Sbjct: 179 NVCVPQQVTVGK--PISWISCGYYHSAFVTTEGQLYTFGEPECGKLG 223



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 38/102 (37%), Positives = 61/102 (59%), Gaps = 3/102 (2%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRY 192
           ++G  Q GQLGLGT   ++ +P+ I+  +   +  IA G  HTA +T+ G +Y +G GR+
Sbjct: 265 TFGLGQFGQLGLGTFLFETSVPKAIEHIKDQKISFIACGENHTALITDMGLMYTFGDGRH 324

Query: 193 GNLGLGDRN--DRFVPEKVSSVEGDKMVLVACGWRHTITVSS 312
           G LGLG  N  ++F+P   S+     + LV+CG  HT+  ++
Sbjct: 325 GKLGLGLENSTNQFIPTLCSNFLRFIVQLVSCGGCHTLVFAT 366



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 34/101 (33%), Positives = 50/101 (49%)
 Frame = +1

Query: 259 DKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISG 438
           D    ++CG  HT  V+ +  LY +G + +GQLG G       P  V+ALK       + 
Sbjct: 35  DVPTFLSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAAC 94

Query: 439 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 561
           G  HT+  T  GK+Y  G N  GQ+G GD  +  +   ++F
Sbjct: 95  GRNHTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISF 135

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>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in|
            mitosis A-related kinase 8) (NimA-related protein kinase
            8)
          Length = 698

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 57/198 (28%), Positives = 95/198 (47%), Gaps = 14/198 (7%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G  +++G   NG LG G   D   P  ++A  G  +  +A GA H  A++ DG+++ WG 
Sbjct: 416  GIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGASHVLALSTDGELFAWGR 475

Query: 184  GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG- 360
            G  G LGLG R     P++V    G +   V CG   ++ ++S G +   G +++ +LG 
Sbjct: 476  GDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSPGRVLACGSNRFNKLGL 535

Query: 361  -HGDFEDHLVPHK--VEALKDSSTSQ----------ISGGWRHTMALTSDGKLYGWGWNK 501
             H   ++  VP++   EAL  +              +  G  H+ A+T+ G  Y +G N+
Sbjct: 536  DHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQ 595

Query: 502  FGQVGAGDNADHCSPAQV 555
             GQ+G        +P +V
Sbjct: 596  HGQLGTSSRRVSRAPCRV 613



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 49/188 (26%), Positives = 87/188 (46%), Gaps = 14/188 (7%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G   +WGR   G+LGLGT E    PQ +    G   + +  G + +  +T  G +   G 
Sbjct: 468  GELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSPGRVLACGS 527

Query: 184  GRYGNLGLG--------------DRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGS 321
             R+  LGL               +    F P   + ++ + ++ V  G  H+  +++SG 
Sbjct: 528  NRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLGTAHSAAITASGD 587

Query: 322  LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 501
             YT+G +++GQLG         P +V+ L+      ++ G   T+A+ ++G++Y WG   
Sbjct: 588  CYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWGKGT 647

Query: 502  FGQVGAGD 525
             G++G  D
Sbjct: 648  RGRLGRRD 655



 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 54/160 (33%), Positives = 81/160 (50%), Gaps = 4/160 (2%)
 Frame = +1

Query: 76  PQTIQAF----EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKV 243
           PQ +  F     G+++K +A G   TA +T+ G I  +G G  G LG G+  D   P  V
Sbjct: 384 PQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIV 443

Query: 244 SSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSST 423
            ++ G +MV VACG  H + +S+ G L+ +G    G+LG G  E H  P +V        
Sbjct: 444 EALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEA 503

Query: 424 SQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCS 543
            ++  G   +M LTS G++   G N+F ++G     DH S
Sbjct: 504 QRVVCGIDSSMILTSPGRVLACGSNRFNKLG----LDHLS 539



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 50/156 (32%), Positives = 70/156 (44%), Gaps = 7/156 (4%)
 Frame = +1

Query: 109 VKMIAAGAEHTAAVTEDGDIYGW-------GWGRYGNLGLGDRNDRFVPEKVSSVEGDKM 267
           V  +AAG    A VT  G +  W       G G      +     +FV   +    G  +
Sbjct: 340 VVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGTLLPGAVELPQPQFVSRFLEGQSGVTI 399

Query: 268 VLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWR 447
             VACG   T  ++  G + T+G    G LGHG+  D   P  VEAL      Q++ G  
Sbjct: 400 KHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGAS 459

Query: 448 HTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 555
           H +AL++DG+L+ WG    G++G G    H  P QV
Sbjct: 460 HVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQV 495



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 37/92 (40%), Positives = 53/92 (57%)
 Frame = +1

Query: 127 GAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITV 306
           G  H+AA+T  GD Y +G  ++G LG   R     P +V  +EG KMV+VACG   T+ V
Sbjct: 575 GTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAV 634

Query: 307 SSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVE 402
            + G +Y++G    G+LG  D ED  +P  V+
Sbjct: 635 GAEGEVYSWGKGTRGRLGRRD-EDAGLPRPVQ 665



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 35/102 (34%), Positives = 51/102 (50%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           +G   ++G NQ+GQLG  +   S  P  +Q  EGI + M+A G   T AV  +G++Y WG
Sbjct: 585 SGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWG 644

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITV 306
            G  G LG  D  D  +P  V   E    ++ +    H  T+
Sbjct: 645 KGTRGRLGRRD-EDAGLPRPVQLDETHPYMVTSVSCCHGNTL 685

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>RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regulator homolog|
          Length = 1392

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 55/156 (35%), Positives = 85/156 (54%), Gaps = 4/156 (2%)
 Frame = +1

Query: 73   LPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSV 252
            LP+ ++ + G   + IA GAEH   ++  G +  WG  R+G  G+G     F    +  V
Sbjct: 767  LPRVLE-YPGGRPRAIACGAEHILVLSSSGQLSAWGGNRFGQCGVGHS---FRIANLHQV 822

Query: 253  EGDKMVL--VACGWRHTITVSSSGSLYTYGWSKYGQLGHG--DFEDHLVPHKVEALKDSS 420
            +GD   +  +ACG  H+  + S GSL+T+GW  +GQLGHG  +  + LVP +V  L    
Sbjct: 823  DGDWPAIEKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGL-ICK 881

Query: 421  TSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDN 528
             +QI+ G  HT+ LT  G++   G   +GQ+G  D+
Sbjct: 882  VTQIACGRAHTVVLTDTGRVLVCGSGSYGQMGVDDD 917



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 50/170 (29%), Positives = 87/170 (51%), Gaps = 4/170 (2%)
 Frame = +1

Query: 1    AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG--ISVKMIAAGAEHTAAVTEDGDIYG 174
            +G   +WG N+ GQ G+G    S     +   +G   +++ IA G  H+A +  DG ++ 
Sbjct: 794  SGQLSAWGGNRFGQCGVG---HSFRIANLHQVDGDWPAIEKIACGQFHSAFICSDGSLWT 850

Query: 175  WGWGRYGNLGLGDRN--DRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKY 348
            +GWG +G LG G RN  ++ VP +V+ +   K+  +ACG  HT+ ++ +G +   G   Y
Sbjct: 851  FGWGVWGQLGHGGRNNSNQLVPTRVNGLI-CKVTQIACGRAHTVVLTDTGRVLVCGSGSY 909

Query: 349  GQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWN 498
            GQ+G  D    +       L       I+  + H++ +T D +++ WG N
Sbjct: 910  GQMGVDDDIKKVFAFTPLPLGPLRVRDIATHYYHSICITEDNRVFEWGRN 959



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 61/221 (27%), Positives = 91/221 (41%), Gaps = 44/221 (19%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G  L  G    GQ+G+      +   T      + V+ IA    H+  +TED  ++ WG 
Sbjct: 899  GRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDIATHYYHSICITEDNRVFEWGR 958

Query: 184  GRYG------------------------------------NLGLG---DRNDRFVPEKVS 246
                                                    NL L     R D  + E   
Sbjct: 959  NPQELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNGSTPRVNLNLPAEIPREDLGLREVKH 1018

Query: 247  SVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTS 426
             ++G+ +V VACG  H+  ++S G+LYT+G     QLGHG+  + + PH+V     +   
Sbjct: 1019 FLDGN-IVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGAKWV 1077

Query: 427  QISGGWRHTMALTSDGKLYGWGWNKFGQVGA-----GDNAD 534
             +S G  HT+A T DG ++ WG N FGQ G      G++AD
Sbjct: 1078 NVSLGNNHTIASTDDGSVFAWGKNDFGQCGVLTKKNGNSAD 1118



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 52/230 (22%), Positives = 87/230 (37%), Gaps = 43/230 (18%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDS--LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGW 177
            G   ++G    GQLG G   +S  L+P  +       V  IA G  HT  +T+ G +   
Sbjct: 846  GSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLI-CKVTQIACGRAHTVVLTDTGRVLVC 904

Query: 178  GWGRYGNLGLGDRNDR---FVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYG---- 336
            G G YG +G+ D   +   F P  +  +   ++  +A  + H+I ++    ++ +G    
Sbjct: 905  GSGSYGQMGVDDDIKKVFAFTPLPLGPL---RVRDIATHYYHSICITEDNRVFEWGRNPQ 961

Query: 337  --------WSKYGQLGHGDFEDHLVP--------------------------HKVEALKD 414
                      K       + ED   P                           +V+   D
Sbjct: 962  ELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNGSTPRVNLNLPAEIPREDLGLREVKHFLD 1021

Query: 415  SSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP 564
             +   ++ G  H+  +TS+G LY WG     Q+G G+  +   P QV  P
Sbjct: 1022 GNIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEP 1071

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>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in|
            mitosis A-related kinase 8) (NimA-related protein kinase
            8) (NIMA-related kinase 12a)
          Length = 692

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 56/198 (28%), Positives = 91/198 (45%), Gaps = 14/198 (7%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G  +++G   NG LG G+  D   P  ++A  G  +  +A GA H  A++ + +++ WG 
Sbjct: 410  GIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGR 469

Query: 184  GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG- 360
            G  G LGLG R     P++V    G +   V CG   ++ ++  G     G +++ +LG 
Sbjct: 470  GDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGL 529

Query: 361  -HGDFEDHLVPH-KVE-----------ALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 501
             H    +  VPH +VE            L       I  G  H+ A+T+ G  Y +G N+
Sbjct: 530  DHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQ 589

Query: 502  FGQVGAGDNADHCSPAQV 555
             GQ+G        +P +V
Sbjct: 590  HGQLGTNTRRGSRAPCKV 607



 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 49/184 (26%), Positives = 88/184 (47%), Gaps = 14/184 (7%)
 Frame = +1

Query: 16   SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
            +WGR  +G+LGLGT E    PQ +    G   + +  G + +  +T  G     G  R+ 
Sbjct: 466  AWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFN 525

Query: 196  NLGLGDRN-------DRFVPEKVS-------SVEGDKMVLVACGWRHTITVSSSGSLYTY 333
             LGL   +        + V E +S        ++ + ++ +  G  H+  V++SG  YT+
Sbjct: 526  KLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTF 585

Query: 334  GWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQV 513
            G +++GQLG         P KV+ L+    + ++ G   T+A+ ++ ++Y WG    G++
Sbjct: 586  GSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRL 645

Query: 514  GAGD 525
            G  D
Sbjct: 646  GRRD 649



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 54/167 (32%), Positives = 79/167 (47%), Gaps = 4/167 (2%)
 Frame = +1

Query: 76  PQTIQAF----EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKV 243
           PQ I  F     G+++K +A G   TA +T+ G I  +G G  G LG G   D   P  V
Sbjct: 378 PQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIV 437

Query: 244 SSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSST 423
            ++ G +MV VACG  H + +S+   L+ +G    G+LG G  E H  P +V        
Sbjct: 438 EALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEA 497

Query: 424 SQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP 564
            ++  G   +M LT  G+    G N+F ++G     DH S  +   P
Sbjct: 498 QRVVCGIDSSMILTVPGQALACGSNRFNKLG----LDHLSLGEEPVP 540



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 47/149 (31%), Positives = 73/149 (48%), Gaps = 16/149 (10%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGL---GTTEDSLLPQTIQAFEGISVKMIAA-------------GAE 135
           G  L+ G N+  +LGL      E+ +  Q ++  E +S  ++ +             G  
Sbjct: 514 GQALACGSNRFNKLGLDHLSLGEEPVPHQQVE--EALSFTLLGSAPLDQEPLLSIDLGTA 571

Query: 136 HTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSS 315
           H+AAVT  GD Y +G  ++G LG   R     P KV  +EG KM +VACG   T+ + + 
Sbjct: 572 HSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAE 631

Query: 316 GSLYTYGWSKYGQLGHGDFEDHLVPHKVE 402
             +Y++G    G+LG  D ED  +P  V+
Sbjct: 632 SEVYSWGKGARGRLGRRD-EDAGLPRPVQ 659



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 28/73 (38%), Positives = 40/73 (54%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           +G   ++G NQ+GQLG  T   S  P  +Q  EGI + M+A G   T A+  + ++Y WG
Sbjct: 579 SGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWG 638

Query: 181 WGRYGNLGLGDRN 219
            G  G LG  D +
Sbjct: 639 KGARGRLGRRDED 651

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>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase)
          Length = 944

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 54/168 (32%), Positives = 82/168 (48%), Gaps = 8/168 (4%)
 Frame = +1

Query: 76  PQTIQAFEG-ISVKMIAAGAEHTAAVTEDGDIYGW-----GWGRYGNLGLGDRNDRFVPE 237
           PQ +  F+G    + + AG  H A VT + ++Y W     G   +G LG GDR     P+
Sbjct: 341 PQKLDVFKGGWRARQVCAGDAHFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQPK 400

Query: 238 KVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDF--EDHLVPHKVEALK 411
            V  ++G  +  V+CG   T+ ++  G LY++G   YG LG       + L P  V+   
Sbjct: 401 HVEKLQGKSVQKVSCGSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFL 460

Query: 412 DSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 555
           +    Q+S G  H MALT    +Y WG  ++G++G     D  SP +V
Sbjct: 461 NEPVDQVSCGDSHIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKV 508



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 57/193 (29%), Positives = 88/193 (45%), Gaps = 15/193 (7%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDS--LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGW 177
            G   S+G +  G LG+  +  S  L P  +  F    V  ++ G  H  A+T    +Y W
Sbjct: 427  GQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSCGDSHIMALTRSKSVYSW 486

Query: 178  GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
            G G YG LGL   +D + P+KV    G  +V V CG   +  ++ +G +   G +++ +L
Sbjct: 487  GCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCGSDGSFLLTLTGKVLACGLNEHNKL 546

Query: 358  GHGDFEDHLVPHKVEALKDSSTS-------------QISGGWRHTMALTSDGKLYGWGWN 498
            G   +   ++ H+       +TS              IS G  HT A+   G+L  +G N
Sbjct: 547  GLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKIRSISPGRTHTAAIDERGRLLTFGSN 606

Query: 499  KFGQVGAGDNADH 537
            K GQ+G GD   H
Sbjct: 607  KCGQLGVGDYRKH 619



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 50/185 (27%), Positives = 84/185 (45%), Gaps = 14/185 (7%)
 Frame = +1

Query: 16   SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
            SWG  + G+LGL + +D   PQ ++   G+ +  +  G++ +  +T  G +   G   + 
Sbjct: 485  SWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCCGSDGSFLLTLTGKVLACGLNEHN 544

Query: 196  NLGLGD------RNDRF--VPEKVS-----SVEGDKMVLVACGWRHTITVSSSGSLYTYG 336
             LGL         ++ F  VP   S      +   K+  ++ G  HT  +   G L T+G
Sbjct: 545  KLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKIRSISPGRTHTAAIDERGRLLTFG 604

Query: 337  WSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQV 513
             +K GQLG GD+  HL  + +   L      ++S G   T A T+D  ++ WG    G++
Sbjct: 605  SNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSCGDEFTTAATADNHIFAWGNGGNGRL 664

Query: 514  GAGDN 528
                N
Sbjct: 665  AMTPN 669



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 40/133 (30%), Positives = 63/133 (47%), Gaps = 6/133 (4%)
 Frame = +1

Query: 151 TEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC-GWRHTITVSSSGSLY 327
           +   ++Y WG G+              P+K+   +G       C G  H   V+    LY
Sbjct: 326 SRSSEVYVWGGGKT------------TPQKLDVFKGGWRARQVCAGDAHFAVVTVEKELY 373

Query: 328 TY----GWSK-YGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 492
           T+    G SK +GQLGHGD   +  P  VE L+  S  ++S G   T+ +T +G+LY +G
Sbjct: 374 TWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQKVSCGSDFTVCITDEGQLYSFG 433

Query: 493 WNKFGQVGAGDNA 531
            + +G +G   +A
Sbjct: 434 SDYYGCLGVNQSA 446

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>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9)
          Length = 984

 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 8/172 (4%)
 Frame = +1

Query: 76  PQTIQAFE-GISVKMIAAGAEHTAAVTEDGDIYGW-----GWGRYGNLGLGDRNDRFVPE 237
           PQ +   + G S + + AG  H A VT + ++Y W     G   +G LG GD+     P+
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPK 418

Query: 238 KVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE--DHLVPHKVEALK 411
            V  ++G  +  V+CG   T+ V+  G LY +G   YG +G       + L P ++    
Sbjct: 419 HVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFL 478

Query: 412 DSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPE 567
            +   Q+S G  H + LT + ++Y WG  ++G++G     D+ +P +V+ P+
Sbjct: 479 SNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPK 530



 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 50/189 (26%), Positives = 86/189 (45%), Gaps = 15/189 (7%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTE--DSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGW 177
            G   ++G +  G +G+      + L P  +  F    V+ ++ G  H   +T + ++Y W
Sbjct: 445  GQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSW 504

Query: 178  GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
            G G YG LGL    D + P++V   +   +V V CG   T  ++ SG +   G +++ +L
Sbjct: 505  GCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKL 564

Query: 358  GHGDFEDHLVPHKVEALKDSSTS-------------QISGGWRHTMALTSDGKLYGWGWN 498
            G       ++ H+       +TS              I+ G  HT A+   G+L  +G N
Sbjct: 565  GLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCN 624

Query: 499  KFGQVGAGD 525
            K GQ+G G+
Sbjct: 625  KCGQLGVGN 633



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 44/173 (25%), Positives = 75/173 (43%), Gaps = 14/173 (8%)
 Frame = +1

Query: 16   SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
            SWG  + G+LGL + ED   PQ +   + + +  +  G + T  +T+ G +   G   + 
Sbjct: 503  SWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFN 562

Query: 196  NLGLGDRNDRFVPEKV-------------SSVEGDKMVLVACGWRHTITVSSSGSLYTYG 336
             LGL       +  +                +   K+  +A G  HT  +   G L T+G
Sbjct: 563  KLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFG 622

Query: 337  WSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQISGGWRHTMALTSDGKLYGWG 492
             +K GQLG G+++  L  + +   L      ++S G   T+A T D  ++ WG
Sbjct: 623  CNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 41/141 (29%), Positives = 65/141 (46%), Gaps = 8/141 (5%)
 Frame = +1

Query: 163 DIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE-GDKMVLVACGWRHTITVSSSGSLYTY-- 333
           ++Y WG G+              P+K+  ++ G     V  G  H   V+    LYT+  
Sbjct: 348 EVYVWGGGKS------------TPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVN 395

Query: 334 ---GWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF 504
              G   +GQLGHGD   +  P  VE L+  +  Q+S G   T+ +T +G+LY +G + +
Sbjct: 396 MQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYY 455

Query: 505 GQVGAG--DNADHCSPAQVNF 561
           G +G       +   P Q+NF
Sbjct: 456 GCMGVDKVSGPEVLEPMQLNF 476



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 35/133 (26%), Positives = 58/133 (43%), Gaps = 14/133 (10%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLL--------PQTI-----QAFEGISVKMIAAGAEHT 141
           +G  L+ G N+  +LGL      ++        P T      +      ++ IA G  HT
Sbjct: 550 SGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHT 609

Query: 142 AAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHTITVSSSG 318
           AA+ E G +  +G  + G LG+G+   R     +    G K V+ V+CG   TI  +   
Sbjct: 610 AAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDN 669

Query: 319 SLYTYGWSKYGQL 357
            ++ +G    G+L
Sbjct: 670 HIFAWGNGGNGRL 682



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 24/69 (34%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G  L++G N+ GQLG+G  +  L    +     G  V  ++ G E T A T+D  I+ WG
Sbjct: 616 GRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675

Query: 181 WGRYGNLGL 207
            G  G L +
Sbjct: 676 NGGNGRLAM 684

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>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase
           8) (Nek8)
          Length = 979

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 8/172 (4%)
 Frame = +1

Query: 76  PQTIQAFE-GISVKMIAAGAEHTAAVTEDGDIYGW-----GWGRYGNLGLGDRNDRFVPE 237
           PQ +   + G S + + AG  H A VT + ++Y W     G   +G LG GD+     P+
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPK 418

Query: 238 KVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFE--DHLVPHKVEALK 411
            V  ++G  +  V+CG   T+ V+  G LY +G   YG +G       + L P ++    
Sbjct: 419 HVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFL 478

Query: 412 DSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFPE 567
            +   Q+S G  H + LT + ++Y WG  ++G++G     D+ +P +V+ P+
Sbjct: 479 SNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPK 530



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 51/189 (26%), Positives = 86/189 (45%), Gaps = 15/189 (7%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTE--DSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGW 177
            G   ++G +  G +G+      + L P  +  F    V+ ++ G  H   +T + ++Y W
Sbjct: 445  GQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSW 504

Query: 178  GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
            G G YG LGL    D + P+KV   +   +V V CG   T  ++ SG +   G +++ +L
Sbjct: 505  GCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKL 564

Query: 358  GHGDFEDHLVPHKVEALKDSSTS-------------QISGGWRHTMALTSDGKLYGWGWN 498
            G       ++ H+       +TS              I+ G  HT A+   G+L  +G N
Sbjct: 565  GLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCN 624

Query: 499  KFGQVGAGD 525
            K GQ+G G+
Sbjct: 625  KCGQLGVGN 633



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 44/173 (25%), Positives = 75/173 (43%), Gaps = 14/173 (8%)
 Frame = +1

Query: 16   SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
            SWG  + G+LGL + ED   PQ +   + + +  +  G + T  +T+ G +   G   + 
Sbjct: 503  SWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFN 562

Query: 196  NLGLGDRNDRFVPEKV-------------SSVEGDKMVLVACGWRHTITVSSSGSLYTYG 336
             LGL       +  +                +   K+  +A G  HT  +   G L T+G
Sbjct: 563  KLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFG 622

Query: 337  WSKYGQLGHGDFEDHLVPHKVEA-LKDSSTSQISGGWRHTMALTSDGKLYGWG 492
             +K GQLG G+++  L  + +   L      ++S G   T+A T D  ++ WG
Sbjct: 623  CNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 42/141 (29%), Positives = 66/141 (46%), Gaps = 8/141 (5%)
 Frame = +1

Query: 163 DIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE-GDKMVLVACGWRHTITVSSSGSLYTY-- 333
           ++Y WG G+              P+K+  ++ G     V  G  H   V+    LYT+  
Sbjct: 348 EVYVWGGGKS------------TPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVN 395

Query: 334 ---GWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKF 504
              G   +GQLGHGD   +  P  VE L+  +  Q+S G   T+ +T +G+LY +G + +
Sbjct: 396 MQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYY 455

Query: 505 GQVGAGDNA--DHCSPAQVNF 561
           G +G    A  +   P Q+NF
Sbjct: 456 GCMGVDKVAGPEVLEPMQLNF 476



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 35/133 (26%), Positives = 58/133 (43%), Gaps = 14/133 (10%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLL--------PQTI-----QAFEGISVKMIAAGAEHT 141
           +G  L+ G N+  +LGL      ++        P T      +      ++ IA G  HT
Sbjct: 550 SGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHT 609

Query: 142 AAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVL-VACGWRHTITVSSSG 318
           AA+ E G +  +G  + G LG+G+   R     +    G K V+ V+CG   TI  +   
Sbjct: 610 AAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDN 669

Query: 319 SLYTYGWSKYGQL 357
            ++ +G    G+L
Sbjct: 670 HIFAWGNGGNGRL 682



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 24/69 (34%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G  L++G N+ GQLG+G  +  L    +     G  V  ++ G E T A T+D  I+ WG
Sbjct: 616 GRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWG 675

Query: 181 WGRYGNLGL 207
            G  G L +
Sbjct: 676 NGGNGRLAM 684

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>RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromosome|
           condensation protein 1) (Cell cycle regulatory protein)
          Length = 421

 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 63/201 (31%), Positives = 95/201 (47%), Gaps = 21/201 (10%)
 Frame = +1

Query: 4   GXXLSWG--RNQNGQLGL-GTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYG 174
           G    WG  R+ NG +GL    + S++P  +Q    + V  +A+G +H   +T DGD+Y 
Sbjct: 138 GRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYT 195

Query: 175 WGWGRYGNLG-----LGDRNDR------FVPEKVSSVEGDKMVLVA-----CGWRHTITV 306
            G G  G LG       +R  R       VP+ V          V      CG   T  +
Sbjct: 196 LGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAI 255

Query: 307 SSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI--SGGWRHTMALTSDGKL 480
           S  G +Y +G S Y QLG    E   +P  + + K+S+ S +  SGG  HT+ + S+GK 
Sbjct: 256 SHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKA 315

Query: 481 YGWGWNKFGQVGAGDNADHCS 543
           Y  G  ++G++G G+ A+  S
Sbjct: 316 YSLGRAEYGRLGLGEGAEEKS 336



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 44/146 (30%), Positives = 75/146 (51%), Gaps = 3/146 (2%)
 Frame = +1

Query: 127 GAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC--GWRHTI 300
           GA  T A++ +G +YG+G   Y  LG       F+P+ ++S +      V    G  HT+
Sbjct: 248 GAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTV 307

Query: 301 TVSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGK 477
            + S G  Y+ G ++YG+LG G+  E+  +P  +  L   + S ++ G     A+T DG+
Sbjct: 308 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP--AVSSVACGASVGYAVTKDGR 365

Query: 478 LYGWGWNKFGQVGAGDNADHCSPAQV 555
           ++ WG     Q+G G + D  SP ++
Sbjct: 366 VFAWGMGTNYQLGTGQDEDAWSPVEM 391



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 57/193 (29%), Positives = 88/193 (45%), Gaps = 21/193 (10%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDS--LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYG 174
           +G   S+G N  G LG  T+ +   ++P  ++  E   V  ++AG  HTAA+T+DG ++ 
Sbjct: 85  SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTDDGRVFL 142

Query: 175 WGWGRYGNLGLG---DRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSK 345
           WG  R  N  +G         VP +V       +V VA G  H + +++ G LYT G  +
Sbjct: 143 WGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGE 200

Query: 346 YGQL-----------GHGDFEDHLVPHKVEALKDSSTSQIS-----GGWRHTMALTSDGK 477
            GQL           G    E  LVP  V      S   +       G   T A++ +G 
Sbjct: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260

Query: 478 LYGWGWNKFGQVG 516
           +YG+G + + Q+G
Sbjct: 261 VYGFGLSNYHQLG 273



 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 53/178 (29%), Positives = 85/178 (47%), Gaps = 7/178 (3%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI--SVKMIAAGAEHTAAVTEDGDIYGW 177
           G  L+ G+   GQLGLG   ++++ +   A   I   V    AG  HT  +++ G +Y +
Sbjct: 35  GLVLTLGQGDVGQLGLG---ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSF 91

Query: 178 GWGRYGNLG--LGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYG--WSK 345
           G    G LG          VP KV   E  K+V V+ G  HT  ++  G ++ +G     
Sbjct: 92  GCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149

Query: 346 YGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVG 516
            G +G  +  +  +VP +V+   D    +++ G  H + LT+DG LY  G  + GQ+G
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 34/102 (33%), Positives = 52/102 (50%), Gaps = 3/102 (2%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   S GR + G+LGLG   E+  +P  I     +S   +A GA    AVT+DG ++ WG
Sbjct: 313 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVS--SVACGASVGYAVTKDGRVFAWG 370

Query: 181 WGRYGNLGLGDRNDRFVPEKV--SSVEGDKMVLVACGWRHTI 300
            G    LG G   D + P ++    +E   ++ V+ G +HT+
Sbjct: 371 MGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412

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>RCC1_XENLA (P25183) Regulator of chromosome condensation|
          Length = 424

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 64/191 (33%), Positives = 95/191 (49%), Gaps = 18/191 (9%)
 Frame = +1

Query: 25  RNQNGQLGL-GTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNL 201
           R+ NG +GL    + S++P  +Q      V  IA+G +H   +T DGD+Y  G G  G L
Sbjct: 153 RDNNGVIGLLEPMKKSMVPVQVQI--NTPVIKIASGNDHLVLLTVDGDLYTSGCGEQGQL 210

Query: 202 G-----LGDRNDR------FVPEKVS-SVEGDKMVL---VACGWRHTITVSSSGSLYTYG 336
           G       +R  R       VP+ +    +G   V    V CG   T  VS  G +Y +G
Sbjct: 211 GRVPERFTNRGGRKGLERLLVPQCIHLKAKGSGRVHFQDVFCGAYFTFAVSQEGHVYGFG 270

Query: 337 WSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI--SGGWRHTMALTSDGKLYGWGWNKFGQ 510
            S Y QLG  + +    P  + + K+S+ S I  SGG  HT+ + S+GK Y  G  ++G+
Sbjct: 271 LSNYHQLGTKNTQACYAPQNLTSFKNSTKSWIGFSGGQHHTVCVDSEGKAYSLGRAEYGR 330

Query: 511 VGAGDNADHCS 543
           +G G+NA+  S
Sbjct: 331 LGLGENAEEQS 341



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 52/183 (28%), Positives = 91/183 (49%), Gaps = 7/183 (3%)
 Frame = +1

Query: 28  NQNGQLGLGTTEDSLLPQTI----QAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
           N+ G+ GL   E  L+PQ I    +    +  + +  GA  T AV+++G +YG+G   Y 
Sbjct: 219 NRGGRKGL---ERLLVPQCIHLKAKGSGRVHFQDVFCGAYFTFAVSQEGHVYGFGLSNYH 275

Query: 196 NLGLGDRNDRFVPEKVSSVEGDKMVLVAC--GWRHTITVSSSGSLYTYGWSKYGQLGHGD 369
            LG  +    + P+ ++S +      +    G  HT+ V S G  Y+ G ++YG+LG G+
Sbjct: 276 QLGTKNTQACYAPQNLTSFKNSTKSWIGFSGGQHHTVCVDSEGKAYSLGRAEYGRLGLGE 335

Query: 370 -FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSP 546
             E+   P  +  L     + ++ G   + A+++DG ++ WG     Q+G G+  D  SP
Sbjct: 336 NAEEQSEPTPIPDLP--KINSVASGASVSYAVSTDGCVFAWGMGTNLQLGTGEEEDVWSP 393

Query: 547 AQV 555
            Q+
Sbjct: 394 EQM 396



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 47/157 (29%), Positives = 72/157 (45%), Gaps = 4/157 (2%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI--AAGAEHTAAVTEDGDIYGW 177
           G    +G +   QLG   T+    PQ + +F+  +   I  + G  HT  V  +G  Y  
Sbjct: 264 GHVYGFGLSNYHQLGTKNTQACYAPQNLTSFKNSTKSWIGFSGGQHHTVCVDSEGKAYSL 323

Query: 178 GWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
           G   YG LGLG+ N     E     +  K+  VA G   +  VS+ G ++ +G     QL
Sbjct: 324 GRAEYGRLGLGE-NAEEQSEPTPIPDLPKINSVASGASVSYAVSTDGCVFAWGMGTNLQL 382

Query: 358 GHGDFEDHLVPHKV--EALKDSSTSQISGGWRHTMAL 462
           G G+ ED   P ++  + L+D     +S G +HT+ L
Sbjct: 383 GTGEEEDVWSPEQMTGKHLEDREVLSVSSGGQHTVLL 419



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 45/122 (36%), Positives = 64/122 (52%), Gaps = 3/122 (2%)
 Frame = +1

Query: 136 HTAAVTEDGDIYGWGWGRYGNLGLG-DRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSS 312
           H +  T  G +   G G  G LGLG D  +R  P  V+  E   +V  A G  HT+ + +
Sbjct: 33  HPSHGTVGGQVLTLGQGDVGQLGLGEDIMERKKPALVTLTED--IVQAAAGGMHTVCLGA 90

Query: 313 SGSLYTYGWSKYGQLGHGDFED--HLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYG 486
           SGS+YT+G +  G LG    E+   + P KVE  +     Q+S G  HT ALT DG+++ 
Sbjct: 91  SGSIYTFGCNDEGALGRDTSEEGSEMQPGKVELAE--KVVQVSAGDSHTAALTEDGRVFV 148

Query: 487 WG 492
           +G
Sbjct: 149 FG 150



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 56/202 (27%), Positives = 87/202 (43%), Gaps = 18/202 (8%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           +G   ++G N  G LG  T+E+    Q  +      V  ++AG  HTAA+TEDG ++ +G
Sbjct: 91  SGSIYTFGCNDEGALGRDTSEEGSEMQPGKVELAEKVVQVSAGDSHTAALTEDGRVFVFG 150

Query: 181 WGRYGNLGLG---DRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYG 351
             R  N  +G         VP +V       ++ +A G  H + ++  G LYT G  + G
Sbjct: 151 SFRDNNGVIGLLEPMKKSMVPVQVQI--NTPVIKIASGNDHLVLLTVDGDLYTSGCGEQG 208

Query: 352 QL-----------GHGDFEDHLVPHKVEALKDSS----TSQISGGWRHTMALTSDGKLYG 486
           QL           G    E  LVP  +      S       +  G   T A++ +G +YG
Sbjct: 209 QLGRVPERFTNRGGRKGLERLLVPQCIHLKAKGSGRVHFQDVFCGAYFTFAVSQEGHVYG 268

Query: 487 WGWNKFGQVGAGDNADHCSPAQ 552
           +G + + Q+G   N   C   Q
Sbjct: 269 FGLSNYHQLGT-KNTQACYAPQ 289



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 52/178 (29%), Positives = 85/178 (47%), Gaps = 7/178 (3%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMI--AAGAEHTAAVTEDGDIYGW 177
           G  L+ G+   GQLGLG   + ++ +   A   ++  ++  AAG  HT  +   G IY +
Sbjct: 41  GQVLTLGQGDVGQLGLG---EDIMERKKPALVTLTEDIVQAAAGGMHTVCLGASGSIYTF 97

Query: 178 GWGRYGNLG--LGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYG--WSK 345
           G    G LG    +      P KV   E  K+V V+ G  HT  ++  G ++ +G     
Sbjct: 98  GCNDEGALGRDTSEEGSEMQPGKVELAE--KVVQVSAGDSHTAALTEDGRVFVFGSFRDN 155

Query: 346 YGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVG 516
            G +G  +  +  +VP +V+   ++   +I+ G  H + LT DG LY  G  + GQ+G
Sbjct: 156 NGVIGLLEPMKKSMVPVQVQI--NTPVIKIASGNDHLVLLTVDGDLYTSGCGEQGQLG 211

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>RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 63/201 (31%), Positives = 93/201 (46%), Gaps = 21/201 (10%)
 Frame = +1

Query: 4   GXXLSWG--RNQNGQLGL-GTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYG 174
           G    WG  R+ NG +GL    + S++P  +Q      V  +A+G +H   +T DGD+Y 
Sbjct: 138 GRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DAPVVKVASGNDHLVMLTNDGDLYT 195

Query: 175 WGWGRYGNLG-----LGDRNDR------FVPE----KVSSVEGDKMVLVA-CGWRHTITV 306
            G G  G LG       +R  R       VP     K     G      A CG   T  +
Sbjct: 196 LGCGEQGQLGRVPELFANRGGRQGLGRLLVPRCVLLKSRGTRGRVRFQDAFCGAYFTFAI 255

Query: 307 SSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI--SGGWRHTMALTSDGKL 480
           S  G +Y +G S Y QLG        +P  + + K+S+ S +  SGG  HT+ + S+GK 
Sbjct: 256 SREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKA 315

Query: 481 YGWGWNKFGQVGAGDNADHCS 543
           Y  G  ++G++G G+ A+  S
Sbjct: 316 YSLGRAEYGRLGLGEGAEEKS 336



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 51/184 (27%), Positives = 90/184 (48%), Gaps = 8/184 (4%)
 Frame = +1

Query: 28  NQNGQLGLGTTEDSLLPQTI----QAFEG-ISVKMIAAGAEHTAAVTEDGDIYGWGWGRY 192
           N+ G+ GLG     L+P+ +    +   G +  +    GA  T A++ +G +YG+G   Y
Sbjct: 213 NRGGRQGLGRL---LVPRCVLLKSRGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNY 269

Query: 193 GNLGLGDRNDRFVPEKVSSVEGDKMVLVAC--GWRHTITVSSSGSLYTYGWSKYGQLGHG 366
             LG       F+P+ ++S +      V    G  HT+ + S G  Y+ G ++YG+LG G
Sbjct: 270 HQLGTPGTGSCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLG 329

Query: 367 D-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCS 543
           +  E+  +P  +  L     S ++ G     A++ DG+++ WG     Q+G G + D  S
Sbjct: 330 EGAEEKSIPTLISRLP--VVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWS 387

Query: 544 PAQV 555
           P ++
Sbjct: 388 PVEM 391



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 60/194 (30%), Positives = 90/194 (46%), Gaps = 22/194 (11%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDS--LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYG 174
           +G   S+G N  G LG  T+ +   ++P  ++  E   V  ++AG  HTAA+TEDG ++ 
Sbjct: 85  SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTEDGRVFL 142

Query: 175 WGWGRYGNLGLG---DRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSK 345
           WG  R  N  +G         VP +V       +V VA G  H + +++ G LYT G  +
Sbjct: 143 WGSFRDNNGVIGLLEPMKKSMVPVQVQL--DAPVVKVASGNDHLVMLTNDGDLYTLGCGE 200

Query: 346 YGQLGHGD--FEDH---------LVPHKVEALKDSST------SQISGGWRHTMALTSDG 474
            GQLG     F +          LVP  V  LK   T           G   T A++ +G
Sbjct: 201 QGQLGRVPELFANRGGRQGLGRLLVPRCV-LLKSRGTRGRVRFQDAFCGAYFTFAISREG 259

Query: 475 KLYGWGWNKFGQVG 516
            +YG+G + + Q+G
Sbjct: 260 HVYGFGLSNYHQLG 273



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 54/178 (30%), Positives = 86/178 (48%), Gaps = 7/178 (3%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI--SVKMIAAGAEHTAAVTEDGDIYGW 177
           G  L+ G+   GQLGLG   +S+L +   A   +   V    AG  HT  +++ G +Y +
Sbjct: 35  GLVLTLGQGDVGQLGLG---ESVLERKKPALVPLLQDVVQAEAGGMHTVCLSQSGQVYSF 91

Query: 178 GWGRYGNLG--LGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYG--WSK 345
           G    G LG          VP KV   E  K+V V+ G  HT  ++  G ++ +G     
Sbjct: 92  GCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTEDGRVFLWGSFRDN 149

Query: 346 YGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVG 516
            G +G  +  +  +VP +V+   D+   +++ G  H + LT+DG LY  G  + GQ+G
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQL--DAPVVKVASGNDHLVMLTNDGDLYTLGCGEQGQLG 205



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 33/102 (32%), Positives = 53/102 (51%), Gaps = 3/102 (2%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   S GR + G+LGLG   E+  +P  I     +S   +A GA    AV++DG ++ WG
Sbjct: 313 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVS--SVACGASVGYAVSKDGRVFAWG 370

Query: 181 WGRYGNLGLGDRNDRFVPEKVS--SVEGDKMVLVACGWRHTI 300
            G    LG G   D + P +++   +E   ++ V+ G +HT+
Sbjct: 371 MGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTV 412

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>RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 63/208 (30%), Positives = 96/208 (46%), Gaps = 28/208 (13%)
 Frame = +1

Query: 4   GXXLSWG--RNQNGQLGL-GTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYG 174
           G    WG  R+ NG +GL    + S++P  +Q    + V  +A+G +H   +T DGD+Y 
Sbjct: 138 GRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DMPVVKVASGNDHLVMLTTDGDLYT 195

Query: 175 WGWGRYGNLGLGDRNDRFVPEKVSSVEG---------DKMVLVA--------------CG 285
            G G  G LG        VPE  ++  G          K VL+               CG
Sbjct: 196 LGCGEQGQLGR-------VPELFANRGGRQGLERLLVPKCVLLKSRGSRGRVRFQDAFCG 248

Query: 286 WRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI--SGGWRHTMA 459
              T  +S  G +Y +G S Y QLG        +P  + + K+S+ S +  SGG  HT+ 
Sbjct: 249 AYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKNSTKSWVGFSGGQHHTIC 308

Query: 460 LTSDGKLYGWGWNKFGQVGAGDNADHCS 543
           + S+GK Y  G  ++G++G G+ A+  S
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKS 336



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 44/146 (30%), Positives = 74/146 (50%), Gaps = 3/146 (2%)
 Frame = +1

Query: 127 GAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC--GWRHTI 300
           GA  T A++ +G +YG+G   Y  LG       F+P+ ++S +      V    G  HTI
Sbjct: 248 GAYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKNSTKSWVGFSGGQHHTI 307

Query: 301 TVSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGK 477
            + S G  Y+ G ++YG+LG G+  E+  +P  +  L     S ++ G     A++ DG+
Sbjct: 308 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLP--VVSSVACGASVGYAVSKDGR 365

Query: 478 LYGWGWNKFGQVGAGDNADHCSPAQV 555
           ++ WG     Q+G G + D  SP ++
Sbjct: 366 VFAWGMGTNYQLGTGQDEDAWSPVEM 391



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 59/198 (29%), Positives = 90/198 (45%), Gaps = 21/198 (10%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDS--LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYG 174
           +G   S+G N  G LG  T+ +   ++P  ++  E   V  ++AG  HTAA+TEDG ++ 
Sbjct: 85  SGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTEDGRVFL 142

Query: 175 WGWGRYGNLGLG---DRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSK 345
           WG  R  N  +G         VP +V       +V VA G  H + +++ G LYT G  +
Sbjct: 143 WGSFRDNNGVIGLLEPMKKSMVPVQVQL--DMPVVKVASGNDHLVMLTTDGDLYTLGCGE 200

Query: 346 YGQL-----------GHGDFEDHLVPHKVEALKDSSTSQIS-----GGWRHTMALTSDGK 477
            GQL           G    E  LVP  V      S  ++       G   T A++ +G 
Sbjct: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVLLKSRGSRGRVRFQDAFCGAYLTFAISREGH 260

Query: 478 LYGWGWNKFGQVGAGDNA 531
           +YG+G + + Q+G    A
Sbjct: 261 VYGFGLSNYHQLGTPGTA 278



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 54/178 (30%), Positives = 84/178 (47%), Gaps = 7/178 (3%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGI--SVKMIAAGAEHTAAVTEDGDIYGW 177
           G  L+ G+   GQLGLG   +S+L +   A   +   V    AG  HT  + + G +Y +
Sbjct: 35  GLVLTLGQGDVGQLGLG---ESVLERKKPALVPLLQDVVQAEAGGMHTVCLNQSGQVYSF 91

Query: 178 GWGRYGNLG--LGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYG--WSK 345
           G    G LG          VP KV   E  K+V V+ G  HT  ++  G ++ +G     
Sbjct: 92  GCNDEGALGRDTSVEGSEMVPGKVELQE--KVVQVSAGDSHTAALTEDGRVFLWGSFRDN 149

Query: 346 YGQLGHGD-FEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVG 516
            G +G  +  +  +VP +V+   D    +++ G  H + LT+DG LY  G  + GQ+G
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQL--DMPVVKVASGNDHLVMLTTDGDLYTLGCGEQGQLG 205



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 33/102 (32%), Positives = 53/102 (51%), Gaps = 3/102 (2%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGT-TEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   S GR + G+LGLG   E+  +P  I     +S   +A GA    AV++DG ++ WG
Sbjct: 313 GKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVS--SVACGASVGYAVSKDGRVFAWG 370

Query: 181 WGRYGNLGLGDRNDRFVPEKVS--SVEGDKMVLVACGWRHTI 300
            G    LG G   D + P +++   +E   ++ V+ G +HT+
Sbjct: 371 MGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTV 412

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>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)|
            (NimA-related protein kinase 8)
          Length = 697

 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 53/199 (26%), Positives = 89/199 (44%), Gaps = 14/199 (7%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G  +++G   NG LG G   D   P+ ++A  G  +  ++ GA H  AVT + +++ WG 
Sbjct: 417  GIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGASHVLAVTNEREVFSWGR 476

Query: 184  GRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGH 363
            G  G LGL  ++    P++VS     +   V CG   ++ +S+   +   G +++ +LG 
Sbjct: 477  GDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMSTQHQILACGNNRFNKLGL 536

Query: 364  GDF-------------EDHLVPHKVEA-LKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 501
                            E HL      A L       I  G  H++A+T  G+ + +G N+
Sbjct: 537  DKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQ 596

Query: 502  FGQVGAGDNADHCSPAQVN 558
             GQ+G         P QV+
Sbjct: 597  HGQLGCSHRRSSRVPYQVS 615



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 47/181 (25%), Positives = 82/181 (45%), Gaps = 14/181 (7%)
 Frame = +1

Query: 16   SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
            SWGR  NG+LGL T +    PQ +        + +  G + +  ++    I   G  R+ 
Sbjct: 473  SWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMSTQHQILACGNNRFN 532

Query: 196  NLGLGDRNDRFVPEKVSSVEG--------------DKMVLVACGWRHTITVSSSGSLYTY 333
             LGL   +    P     VE               +K+V +  G  H++ V+  G  +T+
Sbjct: 533  KLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTEKIVYIDIGTAHSVAVTEKGQCFTF 592

Query: 334  GWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQV 513
            G +++GQLG        VP++V  L+    +  + G   T+A+ ++G++Y WG    G++
Sbjct: 593  GSNQHGQLGCSHRRSSRVPYQVSGLQ--GITMAACGDAFTLAIGAEGEVYTWGKGARGRL 650

Query: 514  G 516
            G
Sbjct: 651  G 651



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 43/158 (27%), Positives = 70/158 (44%), Gaps = 6/158 (3%)
 Frame = +1

Query: 109 VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNL------GLGDRNDRFVPEKVSSVEGDKMV 270
           V  ++ G      VT+ G +  W     G+        +     +F+   +    G  + 
Sbjct: 342 VIQVSLGRTQKMGVTKSGRLITWEAPSVGSGEPTLPGAVEQMQPQFISRFLEGQSGVTIK 401

Query: 271 LVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRH 450
            V+CG   T  ++  G + T+G    G LGHG+F D   P  VEAL      Q+S G  H
Sbjct: 402 SVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGASH 461

Query: 451 TMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP 564
            +A+T++ +++ WG    G++G      H  P QV+ P
Sbjct: 462 VLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLP 499



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 33/101 (32%), Positives = 50/101 (49%), Gaps = 2/101 (1%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G   ++G NQ+GQLG      S +P  +   +GI+  M A G   T A+  +G++Y WG 
Sbjct: 587 GQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQGIT--MAACGDAFTLAIGAEGEVYTWGK 644

Query: 184 GRYGNLGLGDRNDRFVPEKVSSVEGDKMVL--VACGWRHTI 300
           G  G LG  +  D  +P+ V   E     +  VAC   +T+
Sbjct: 645 GARGRLGRKE-EDFGIPKPVQLDESHAFTVTSVACCHGNTL 684

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>RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)|
          Length = 539

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 59/201 (29%), Positives = 87/201 (43%), Gaps = 26/201 (12%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTE----DSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIY 171
           G   +WG  Q  QLG    E      L PQ +     ISV    AG+ H+ A+   G +Y
Sbjct: 245 GKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISV---GAGSYHSFAIDNKGRVY 301

Query: 172 GWGWG--RYGNLGLGDRNDRFV---PEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYG 336
            WG    R   + + D  +  V   P  V ++EG  +  +  G  HT+ +   G +  +G
Sbjct: 302 AWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEHHTLALLEDGRVLAWG 361

Query: 337 WSKYGQLGHGDFEDHLVPHKVEALKD-----------------SSTSQISGGWRHTMALT 465
                QLG     D+ +P  V  +KD                 ++  Q+  G  H +A+T
Sbjct: 362 RDDRHQLG---IPDNALPETV--VKDEKGNNYYLSTPTIIPGLTNVIQVVCGTHHNLAVT 416

Query: 466 SDGKLYGWGWNKFGQVGAGDN 528
           SDGK+Y WG  +  +VG GDN
Sbjct: 417 SDGKVYSWGSAENYEVGQGDN 437



 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 54/187 (28%), Positives = 84/187 (44%), Gaps = 11/187 (5%)
 Frame = +1

Query: 4   GXXLSWG--RNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGW 177
           G   +WG  R  +G LG   ++      T      I    +A G +H  A+T  G +Y W
Sbjct: 193 GCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMRLPEIC--QLATGTDHIIALTTTGKVYTW 250

Query: 178 GWGRYGNLGLGDRNDR----FVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSK 345
           G G+   LG      R      P+ ++      ++ V  G  H+  + + G +Y +G + 
Sbjct: 251 GNGQQFQLGRRMLERRRLQGLTPQPLAL---KNIISVGAGSYHSFAIDNKGRVYAWGLNI 307

Query: 346 YGQLGHG--DFEDHLV---PHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQ 510
             Q G    D E+  V   P  V+AL+  +   I+GG  HT+AL  DG++  WG +   Q
Sbjct: 308 TRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEHHTLALLEDGRVLAWGRDDRHQ 367

Query: 511 VGAGDNA 531
           +G  DNA
Sbjct: 368 LGIPDNA 374



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 46/155 (29%), Positives = 68/155 (43%), Gaps = 21/155 (13%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDS-----LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDI 168
           G   +WG N   Q G+   ++        P  + A EG +VK I  G  HT A+ EDG +
Sbjct: 298 GRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGGEHHTLALLEDGRV 357

Query: 169 YGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDK---------------MVLVACGWRHTIT 303
             WG      LG+ D     +PE V   E                  ++ V CG  H + 
Sbjct: 358 LAWGRDDRHQLGIPDNA---LPETVVKDEKGNNYYLSTPTIIPGLTNVIQVVCGTHHNLA 414

Query: 304 VSSSGSLYTYGWSKYGQLGHGD-FEDHLVPHKVEA 405
           V+S G +Y++G ++  ++G GD  ED  VP  V +
Sbjct: 415 VTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLVRS 449



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 50/186 (26%), Positives = 86/186 (46%), Gaps = 20/186 (10%)
 Frame = +1

Query: 19  WGRNQNGQLGLGTTEDSLLPQT----IQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWG 186
           +G     +LG+G  E  ++ +     I + + + V  +A G  H+AA++ DG +Y WG  
Sbjct: 76  FGSGSMNELGMGEEEMDVVYRPRLNPILSTDKVGVVDLAVGGMHSAALSHDGRVYTWGVN 135

Query: 187 RYGNLGL---------GDRNDRFVPEKV-SSVEGD----KMVLVACGWRHTITVSSSGSL 324
               LG          GD+ D  + E   S VEG     ++  V C    T  ++ +G  
Sbjct: 136 DDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALSHLRVTKVICSDNLTAAITDNGCC 195

Query: 325 YTYGWSKY--GQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWN 498
           +T+G  +   G LG+ D +      +   ++     Q++ G  H +ALT+ GK+Y WG  
Sbjct: 196 FTWGTFRCSDGVLGYSDSQKRTA--EPTQMRLPEICQLATGTDHIIALTTTGKVYTWGNG 253

Query: 499 KFGQVG 516
           +  Q+G
Sbjct: 254 QQFQLG 259



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 50/189 (26%), Positives = 84/189 (44%), Gaps = 18/189 (9%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGT----------TEDSLLPQTIQAFEG----ISVKMIAAGAEHT 141
           G   +WG N +  LG  T           ++ LL  T    EG    + V  +      T
Sbjct: 127 GRVYTWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALSHLRVTKVICSDNLT 186

Query: 142 AAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGS 321
           AA+T++G  + WG  R  +  LG  + +    + + +   ++  +A G  H I ++++G 
Sbjct: 187 AAITDNGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMRLPEICQLATGTDHIIALTTTGK 246

Query: 322 LYTYGWSKYGQLGHGDFE----DHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGW 489
           +YT+G  +  QLG    E      L P  + ALK  +   +  G  H+ A+ + G++Y W
Sbjct: 247 VYTWGNGQQFQLGRRMLERRRLQGLTPQPL-ALK--NIISVGAGSYHSFAIDNKGRVYAW 303

Query: 490 GWNKFGQVG 516
           G N   Q G
Sbjct: 304 GLNITRQCG 312

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>MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4641

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 33/85 (38%), Positives = 53/85 (62%)
 Frame = +1

Query: 262  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 441
            + V V+CG+ H++ +  +G +YT+G+ ++GQLGHGD      P  V+AL   ST Q++ G
Sbjct: 903  RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPST-QVTAG 961

Query: 442  WRHTMALTSDGKLYGWGWNKFGQVG 516
              HT  L  DG+++ +G    GQ+G
Sbjct: 962  SNHTAVLLMDGQVFTFGSFSKGQLG 986



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 29/81 (35%), Positives = 45/81 (55%)
 Frame = +1

Query: 118  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 297
            ++ G  H+  + E+GD+Y +G+G++G LG GD N R  P  V ++ G     V  G  HT
Sbjct: 907  VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSNHT 965

Query: 298  ITVSSSGSLYTYGWSKYGQLG 360
              +   G ++T+G    GQLG
Sbjct: 966  AVLLMDGQVFTFGSFSKGQLG 986



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 38/136 (27%), Positives = 58/136 (42%), Gaps = 4/136 (2%)
 Frame = +1

Query: 136 HTAAVTEDGDIYGWGWGRYGNLGLGDRNDR----FVPEKVSSVEGDKMVLVACGWRHTIT 303
           H   V EDG I+  G    G  G   ++ R    + P+K+  +EG  +V  AC    +  
Sbjct: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 304 VSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY 483
           +S  G LY +G           + D      V  LK    +Q++ G  HT  L  +G+++
Sbjct: 615 ISKDGELYMFGKDAI-------YSDS--SSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVW 665

Query: 484 GWGWNKFGQVGAGDNA 531
            +G N  GQ G    A
Sbjct: 666 TFGVNNKGQCGRDTGA 681



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 24/67 (35%), Positives = 35/67 (52%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G   ++G  Q+GQLG G       P  +QA  G S + + AG+ HTA +  DG ++ +G 
Sbjct: 921  GDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQ-VTAGSNHTAVLLMDGQVFTFGS 979

Query: 184  GRYGNLG 204
               G LG
Sbjct: 980  FSKGQLG 986



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 24/98 (24%), Positives = 44/98 (44%), Gaps = 3/98 (3%)
 Frame = +1

Query: 76  PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEK---VS 246
           P+ I   EG  V   A     ++ +++DG++Y +G             D    +    V+
Sbjct: 591 PKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFG------------KDAIYSDSSSLVT 638

Query: 247 SVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
            ++G  +  VA G  HT  +  +G ++T+G +  GQ G
Sbjct: 639 DLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCG 676



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 13/33 (39%), Positives = 23/33 (69%)
 Frame = +1

Query: 427  QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGD 525
            Q+S G+ H++ L  +G +Y +G+ + GQ+G GD
Sbjct: 906  QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGD 938

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>HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-) (Protein|
            pam/highwire/rpm-1)
          Length = 5233

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 35/95 (36%), Positives = 57/95 (60%)
 Frame = +1

Query: 232  PEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALK 411
            P+ +       +V VACG  HT+ ++ +G +YT+G ++YGQLG GD +    P +V+   
Sbjct: 957  PQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQV-- 1014

Query: 412  DSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVG 516
              + SQ++ G  HT+ LTS G +Y +G  + GQ+G
Sbjct: 1015 PGAISQVAAGSNHTVLLTSKGMVYTFGNYQKGQLG 1049



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 37/97 (38%), Positives = 52/97 (53%)
 Frame = +1

Query: 70   LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSS 249
            L PQ +Q      V  +A G  HT  +T  G++Y +G  +YG LG GD      P +V  
Sbjct: 955  LAPQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRV-Q 1013

Query: 250  VEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
            V G  +  VA G  HT+ ++S G +YT+G  + GQLG
Sbjct: 1014 VPG-AISQVAAGSNHTVLLTSKGMVYTFGNYQKGQLG 1049



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 36/131 (27%), Positives = 59/131 (45%), Gaps = 4/131 (3%)
 Frame = +1

Query: 136  HTAAVTEDGDIYGWGWGRYGNLGLGDRNDR----FVPEKVSSVEGDKMVLVACGWRHTIT 303
            H   V +DG ++  G  R G  G   +N R      P+K++ ++G  +V  AC    +  
Sbjct: 662  HALLVNDDGTVFFAGTARRGEDGDSSKNRRQPKAVKPKKMTKIDGHVVVHAACNNGTSAF 721

Query: 304  VSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY 483
            V+ +G L  YG        H D         V  L +   ++++ G  H +AL + G+L+
Sbjct: 722  VTKTGKLIMYG----KDTAHCDAMGF-----VSELLEQHVTKVALGKAHCVALNAKGQLF 772

Query: 484  GWGWNKFGQVG 516
             +G N  GQ G
Sbjct: 773  SFGLNNKGQCG 783



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 21/61 (34%), Positives = 34/61 (55%)
 Frame = +1

Query: 382  LVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 561
            L P  ++    S   Q++ G  HT+ LT  G++Y +G N++GQ+G+GD      P +V  
Sbjct: 955  LAPQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQV 1014

Query: 562  P 564
            P
Sbjct: 1015 P 1015

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>WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 16 protein|
           homolog
          Length = 461

 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 48/172 (27%), Positives = 80/172 (46%), Gaps = 7/172 (4%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGTTEDSLLPQT-----IQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           S G N +GQ G    ED +  ++     +Q F+G  V  +  G +H+  +T+ G++Y  G
Sbjct: 194 SMGNNSHGQCGRKVVEDEVYSESHKVHRMQDFDG-QVVQVVCGQDHSLFLTDKGEVYSCG 252

Query: 181 WGRYGNLGLGDRNDRFVPEKV-SSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
           WG  G  GLG  N    P K+   + G  +V VA      + +S+ G ++ +G S+Y QL
Sbjct: 253 WGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVATYGDCCLALSADGGVFGWGNSEYLQL 312

Query: 358 GH-GDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQ 510
               D     VP  +         Q++ G      L ++G ++ WG+   G+
Sbjct: 313 ASVTDSTQVNVPRCLPFSGVGKVKQVACGGTGCAVLNAEGHVFVWGYGILGK 364



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 57/198 (28%), Positives = 86/198 (43%), Gaps = 11/198 (5%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   S G   +GQ GLG    +  P  +     G++V  +A   +   A++ DG ++GWG
Sbjct: 246 GEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVATYGDCCLALSADGGVFGWG 305

Query: 181 WGRYGNLG-LGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
              Y  L  + D     VP  +      K+  VACG      +++ G ++ +G   YG L
Sbjct: 306 NSEYLQLASVTDSTQVNVPRCLPFSGVGKVKQVACGGTGCAVLNAEGHVFVWG---YGIL 362

Query: 358 GHGD-FEDHLVPHKV--------EALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQ 510
           G G    +  +P  +        E   +   SQI  G  H  ALT+ G+L+ WG N  G 
Sbjct: 363 GKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQIRCGLSHFAALTNKGELFVWGKNIRGC 422

Query: 511 VGAGDNADHCSPAQVNFP 564
           +G G   D   P +V  P
Sbjct: 423 LGIGRLEDQYFPWRVTMP 440



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 4/102 (3%)
 Frame = +1

Query: 229 VPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLV--PHKVE 402
           VP  +   +  K++ V+CG  H++ ++    +++ G + +GQ G    ED +    HKV 
Sbjct: 161 VPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVH 220

Query: 403 ALK--DSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
            ++  D    Q+  G  H++ LT  G++Y  GW   GQ G G
Sbjct: 221 RMQDFDGQVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLG 262



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 36/113 (31%), Positives = 54/113 (47%), Gaps = 9/113 (7%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLG-----TTEDSLLPQTIQAFEG----ISVKMIAAGAEHTAAVTE 156
           G    WG    G LG G     T    ++P T+         + V  I  G  H AA+T 
Sbjct: 352 GHVFVWGY---GILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQIRCGLSHFAALTN 408

Query: 157 DGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSS 315
            G+++ WG    G LG+G   D++ P +V ++ G+  V VACG  H +T++ S
Sbjct: 409 KGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEP-VDVACGVDHMVTLAKS 459

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>WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 16 protein|
          Length = 464

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 52/178 (29%), Positives = 81/178 (45%), Gaps = 7/178 (3%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGTTEDSLLPQT-----IQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           S G N  GQ G    E+ +  ++     +Q F+G  V  +A G +H+  +T+ G++Y  G
Sbjct: 197 SMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCG 255

Query: 181 WGRYGNLGLGDRNDRFVPEKV-SSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
           WG  G  GLG  N    P K+   + G  ++ VA      + VS+ G L+ +G S+Y QL
Sbjct: 256 WGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQL 315

Query: 358 GH-GDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDN 528
               D     VP  +         Q + G      L  +G ++ WG   +G +G G N
Sbjct: 316 ASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPN 370



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 57/198 (28%), Positives = 85/198 (42%), Gaps = 11/198 (5%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQA-FEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           G   S G   +GQ GLG    +  P  +     G++V  +A   +   AV+ DG ++GWG
Sbjct: 249 GEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWG 308

Query: 181 WGRYGNLG-LGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQL 357
              Y  L  + D     VP  +      K+   ACG      ++  G ++ +G   YG L
Sbjct: 309 NSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGIL 365

Query: 358 GHG-DFEDHLVPHKV--------EALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQ 510
           G G +  +  VP  +        E   +   S+I  G  H  ALT+ G+L+ WG N  G 
Sbjct: 366 GKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGC 425

Query: 511 VGAGDNADHCSPAQVNFP 564
           +G G   D   P +V  P
Sbjct: 426 LGIGRLEDQYFPWRVTMP 443



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 28/102 (27%), Positives = 53/102 (51%), Gaps = 4/102 (3%)
 Frame = +1

Query: 262 KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLV--PHKVEALK--DSSTSQ 429
           +++ V+CG  H++ ++    +++ G + YGQ G    E+ +    H+V  ++  D    Q
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234

Query: 430 ISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 555
           ++ G  H++ LT  G++Y  GW   GQ G G      SP ++
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKL 276



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 27/71 (38%), Positives = 41/71 (57%)
 Frame = +1

Query: 103 ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC 282
           I V  I  G  H AA+T  G+++ WG    G LG+G   D++ P +V ++ G+  V VAC
Sbjct: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEP-VDVAC 451

Query: 283 GWRHTITVSSS 315
           G  H +T++ S
Sbjct: 452 GVDHMVTLAKS 462



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 36/147 (24%), Positives = 60/147 (40%), Gaps = 30/147 (20%)
 Frame = +1

Query: 166 IYGWGWGRYGNLGL--------------GDRNDRFVPEKVSSVEGD-KMVLVACGWRHTI 300
           ++ WG+   G LG+              G R  R +      +E D K+   ACG+  T+
Sbjct: 61  VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL 120

Query: 301 TVSSSGSL---YTYGWSKYGQLGHG--------DFEDHLVPHKV----EALKDSSTSQIS 435
             S +  +   +  G +K  QLG           +E  L P  V    +  +++   Q+S
Sbjct: 121 LSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVS 180

Query: 436 GGWRHTMALTSDGKLYGWGWNKFGQVG 516
            G  H++ LT    ++  G N +GQ G
Sbjct: 181 CGRAHSLVLTDREGVFSMGNNSYGQCG 207

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>MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4711

 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 37/112 (33%), Positives = 61/112 (54%), Gaps = 7/112 (6%)
 Frame = +1

Query: 202  GLGDRNDRFVPEKVSSVEGD-------KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
            G GDR ++   +  +   G        + V V+CG+ H++ +  +G +YT+G+ ++GQLG
Sbjct: 876  GSGDRGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLG 935

Query: 361  HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVG 516
            HGD      P  V+AL   ST Q++    HT  L  DG+++ +G    GQ+G
Sbjct: 936  HGDVNSRGCPTLVQALPGPST-QVTACSNHTAVLLMDGQVFTFGSFSKGQLG 986



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 29/81 (35%), Positives = 46/81 (56%)
 Frame = +1

Query: 118  IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHT 297
            ++ G  H+  + E+GD+Y +G+G++G LG GD N R  P  V ++ G    + AC   HT
Sbjct: 907  VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTACS-NHT 965

Query: 298  ITVSSSGSLYTYGWSKYGQLG 360
              +   G ++T+G    GQLG
Sbjct: 966  AVLLMDGQVFTFGSFSKGQLG 986



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 37/136 (27%), Positives = 58/136 (42%), Gaps = 4/136 (2%)
 Frame = +1

Query: 136 HTAAVTEDGDIYGWGWGRYGNLGLGDRNDR----FVPEKVSSVEGDKMVLVACGWRHTIT 303
           H   V EDG ++  G    G  G   ++ R    + P+K+  +EG  +V  AC    +  
Sbjct: 555 HALLVAEDGSVFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 304 VSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLY 483
           +S  G LY +G           + D      V  LK    +Q++ G  HT  L  +G+++
Sbjct: 615 ISKDGELYMFGKDAI-------YSDS--SSLVSDLKGHFVTQVAMGKAHTCVLMKNGEVW 665

Query: 484 GWGWNKFGQVGAGDNA 531
            +G N  GQ G    A
Sbjct: 666 TFGVNNKGQCGRDTGA 681



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 23/67 (34%), Positives = 34/67 (50%)
 Frame = +1

Query: 4    GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
            G   ++G  Q+GQLG G       P  +QA  G S + + A + HTA +  DG ++ +G 
Sbjct: 921  GDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQ-VTACSNHTAVLLMDGQVFTFGS 979

Query: 184  GRYGNLG 204
               G LG
Sbjct: 980  FSKGQLG 986



 Score = 36.2 bits (82), Expect = 0.066
 Identities = 25/98 (25%), Positives = 44/98 (44%), Gaps = 3/98 (3%)
 Frame = +1

Query: 76  PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEK---VS 246
           P+ I   EG  V   A     ++ +++DG++Y +G             D    +    VS
Sbjct: 591 PKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFG------------KDAIYSDSSSLVS 638

Query: 247 SVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
            ++G  +  VA G  HT  +  +G ++T+G +  GQ G
Sbjct: 639 DLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCG 676



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 13/33 (39%), Positives = 23/33 (69%)
 Frame = +1

Query: 427  QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGD 525
            Q+S G+ H++ L  +G +Y +G+ + GQ+G GD
Sbjct: 906  QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGD 938

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>RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 protein)|
           (Pheromone response pathway component SRM1)
          Length = 482

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 45/156 (28%), Positives = 69/156 (44%), Gaps = 10/156 (6%)
 Frame = +1

Query: 97  EGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRF----VPEKVSSVEGDK 264
           EG  V  +AA    + A+  +G++Y WG  R     LG   D+      P KV +     
Sbjct: 163 EGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYN 222

Query: 265 MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLV------PHKVEALKDSSTS 426
           +V +A G  H + +   G ++ +G  +  QLG    E   +      P  +  +K     
Sbjct: 223 IVQLAPGKDHILFLDEEGMVFAWGNGQQNQLGRKVMERFRLKTLDPRPFGLRHVK----- 277

Query: 427 QISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNAD 534
            I+ G  H  ALT D KL  WG N+FGQ G  ++ +
Sbjct: 278 YIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVE 313



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 43/147 (29%), Positives = 70/147 (47%), Gaps = 17/147 (11%)
 Frame = +1

Query: 13  LSWGRNQNGQLGLGT-TEDSLL---PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           +SWG NQ GQ G+    ED  L   P+ +   + + ++ IAAG  H+  +++DGD+Y  G
Sbjct: 296 VSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLILSQDGDLYSCG 355

Query: 181 WGRYGNLGLGDRN------------DRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSL 324
                 +G+   N             R VP         K   VA G  H++ V+ +G  
Sbjct: 356 RLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNGIA 415

Query: 325 YTYGWSKYGQLGHGDFEDHL-VPHKVE 402
           Y++G+ +   +G G FED   VP +++
Sbjct: 416 YSWGFGETYAVGLGPFEDDTEVPTRIK 442



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 48/186 (25%), Positives = 81/186 (43%), Gaps = 15/186 (8%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSL----LPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIY 171
           G   +WG  +  +  LG  +D +     P  +  F   ++  +A G +H   + E+G ++
Sbjct: 184 GEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVF 243

Query: 172 GWGWGRYGNLGLGDRNDRFVPEKVSSVEGD-------KMVLVACGWRHTITVSSSGSLYT 330
            WG G+   LG      R V E+      D        +  +A G  H   ++    L +
Sbjct: 244 AWGNGQQNQLG------RKVMERFRLKTLDPRPFGLRHVKYIASGENHCFALTKDNKLVS 297

Query: 331 YGWSKYGQLG-HGDFEDHLVPHKVE--ALKDSST-SQISGGWRHTMALTSDGKLYGWGWN 498
           +G +++GQ G   D ED  +  K +  AL D+     I+ G  H++ L+ DG LY  G  
Sbjct: 298 WGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLILSQDGDLYSCGRL 357

Query: 499 KFGQVG 516
              +VG
Sbjct: 358 DMFEVG 363



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 48/204 (23%), Positives = 81/204 (39%), Gaps = 38/204 (18%)
 Frame = +1

Query: 19  WGRNQNGQLGLGT---TEDSLLPQTIQAFEGISVKMI--AAGAEHTAAVTEDGDIYGWGW 183
           WG     +LGLG     ++   P+          K+I  A G  HT A+ E+ +++ WG 
Sbjct: 51  WGTGSMCELGLGPLAKNKEVKRPRLNPFLPRDEAKIISFAVGGMHTLALDEESNVWSWGC 110

Query: 184 GRYGNLGL----------------------GDRND-RFVPEKVSS------VEGDKMVLV 276
              G LG                       GD N+    P K+         EG K+V +
Sbjct: 111 NDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLNELESTPAKIPRESFPPLAEGHKVVQL 170

Query: 277 ACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHL----VPHKVEALKDSSTSQISGGW 444
           A     +  + S+G +Y +G  +  +   G ++D +     P KV      +  Q++ G 
Sbjct: 171 AATDNMSCALFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGK 230

Query: 445 RHTMALTSDGKLYGWGWNKFGQVG 516
            H + L  +G ++ WG  +  Q+G
Sbjct: 231 DHILFLDEEGMVFAWGNGQQNQLG 254



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 22/67 (32%), Positives = 41/67 (61%), Gaps = 3/67 (4%)
 Frame = +1

Query: 112 KMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGD-RNDRFVPEKV--SSVEGDKMVLVAC 282
           K +AAG+ H+ AV ++G  Y WG+G    +GLG   +D  VP ++  ++ +   ++LV C
Sbjct: 397 KSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEVPTRIKNTATQDHNIILVGC 456

Query: 283 GWRHTIT 303
           G + +++
Sbjct: 457 GGQFSVS 463



 Score = 33.1 bits (74), Expect = 0.56
 Identities = 21/76 (27%), Positives = 35/76 (46%), Gaps = 10/76 (13%)
 Frame = +1

Query: 163 DIYGWGWGRYGNLGLG----------DRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSS 312
           DI+ WG G    LGLG           R + F+P      +  K++  A G  HT+ +  
Sbjct: 47  DIFCWGTGSMCELGLGPLAKNKEVKRPRLNPFLPR-----DEAKIISFAVGGMHTLALDE 101

Query: 313 SGSLYTYGWSKYGQLG 360
             +++++G +  G LG
Sbjct: 102 ESNVWSWGCNDVGALG 117

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>RCC1_DROME (P25171) Regulator of chromosome condensation (Chromatin-binding|
           protein Bj1)
          Length = 547

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 38/122 (31%), Positives = 63/122 (51%), Gaps = 2/122 (1%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG 180
           +G   S+G N  G LG  T+ED    +            I+AG  H+A + EDG ++ WG
Sbjct: 92  SGDIYSFGCNDEGALGRDTSEDGSESKPDLIDLPGKALCISAGDSHSACLLEDGRVFAWG 151

Query: 181 WGR--YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQ 354
             R  +GN+GL    ++  P  +  +EG     +A G  H + ++++G ++T G ++ GQ
Sbjct: 152 SFRDSHGNMGLTIDGNKRTP--IDLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQ 209

Query: 355 LG 360
           LG
Sbjct: 210 LG 211



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 45/127 (35%), Positives = 61/127 (48%), Gaps = 4/127 (3%)
 Frame = +1

Query: 109 VKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVE--GDKMVLVAC 282
           ++ IA G  HT  +T D      G   YG LGLGD  D  V EK + V+   +K+V V C
Sbjct: 295 IRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKD--VVEKPTIVKKLTEKIVSVGC 352

Query: 283 GWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQI--SGGWRHTM 456
           G   +  V+  G LY++G     QLG GD +D L P  V +        +  SGG +H +
Sbjct: 353 GEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAI 412

Query: 457 ALTSDGK 477
            L    K
Sbjct: 413 FLVKADK 419



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 46/172 (26%), Positives = 75/172 (43%), Gaps = 1/172 (0%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKM-IAAGAEHTAAVTEDGDIYGWG 180
           G  L  G    GQLGLG  ED L  + +    GI   + I+AG  H   +T+ GDIY +G
Sbjct: 42  GNVLVCGNGDVGQLGLG--EDILERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFG 99

Query: 181 WGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG 360
               G LG     D    +        K + ++ G  H+  +   G ++ +G  +     
Sbjct: 100 CNDEGALGRDTSEDGSESKPDLIDLPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGN 159

Query: 361 HGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVG 516
            G   D      ++ ++ +    I+ G  H + LT+ GK++  G  + GQ+G
Sbjct: 160 MGLTIDGNKRTPIDLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLG 211



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 34/95 (35%), Positives = 48/95 (50%), Gaps = 2/95 (2%)
 Frame = +1

Query: 22  GRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNL 201
           GR + G+LGLG  +D +   TI       +  +  G   + AVT DG +Y WG G    L
Sbjct: 318 GRPEYGRLGLGDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQL 377

Query: 202 GLGDRNDRFVPEKVSS--VEGDKMVLVACGWRHTI 300
           G+GD +D   P  V S   +G  M+L + G +H I
Sbjct: 378 GVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAI 412



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 62/249 (24%), Positives = 90/249 (36%), Gaps = 65/249 (26%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGW 183
           G   +WG  ++    +G T D      I   EG     IA+GA+H   +T  G ++  G 
Sbjct: 145 GRVFAWGSFRDSHGNMGLTIDGNKRTPIDLMEGTVCCSIASGADHLVILTTAGKVFTVGC 204

Query: 184 ---GRYGNL------GLGDRNDR--------------------------FVPEKVSSV-- 252
              G+ G L      G G R  R                          F+ E  + V  
Sbjct: 205 AEQGQLGRLSERSISGEGRRGKRDLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIW 264

Query: 253 --------------EGDKMVL------------VACGWRHTITVSSSGSLYTYGWSKYGQ 354
                         +G +  L            +A G  HT+ +++       G  +YG+
Sbjct: 265 ATGLNNFKQLAHETKGKEFALTPIKTELKDIRHIAGGQHHTVILTTDLKCSVVGRPEYGR 324

Query: 355 LGHGDFEDHLVPHKVEALKDSSTSQISGGWRH--TMALTSDGKLYGWGWNKFGQVGAGDN 528
           LG GD +D  V  K   +K  +   +S G     + A+T DGKLY WG     Q+G GD 
Sbjct: 325 LGLGDVKD--VVEKPTIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDG 382

Query: 529 ADHCSPAQV 555
            D   P  V
Sbjct: 383 DDELEPIVV 391



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 15/47 (31%), Positives = 24/47 (51%), Gaps = 2/47 (4%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTI--QAFEGISVKMIAAGAEH 138
           G   SWG   N QLG+G  +D L P  +  +  +G  + + + G +H
Sbjct: 364 GKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQH 410

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>ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)|
          Length = 333

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 47/162 (29%), Positives = 69/162 (42%), Gaps = 1/162 (0%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGTTEDSLLPQ-TIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRY 192
           ++G N   QLGLG  ED   PQ ++   +G  V+ IA G  H+  +T DG++ G G  R 
Sbjct: 6   AFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDNRR 65

Query: 193 GNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDF 372
           G L       +    +   V    +V VACGW  T+ V + G ++  G   Y      +F
Sbjct: 66  GELDSAQALRQVHDWRPVEVPAP-VVDVACGWDTTVIVDADGRVWQRGGGCY------EF 118

Query: 373 EDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWN 498
               VP     L  +       G      +    ++YGWG N
Sbjct: 119 TQQHVP-----LNSNDERIAVYGCFQNFVVVQGTRVYGWGSN 155



 Score = 33.1 bits (74), Expect = 0.56
 Identities = 19/56 (33%), Positives = 25/56 (44%), Gaps = 7/56 (12%)
 Frame = +1

Query: 58  TEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGD-------IYGWGWGRYGNLG 204
           T   L PQ    F  + V   A G+EH    T + +       +Y WGWG +GN G
Sbjct: 249 THSQLFPQERLDFPIVGV---ATGSEHGILTTANQEGKSHCYNVYCWGWGEHGNCG 301

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>ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1657

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 28/68 (41%), Positives = 39/68 (57%)
 Frame = +1

Query: 322 LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 501
           ++T+G  K GQLGHGD    L P  V+ L       +  G  H++ALT+  ++Y WG N 
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587

Query: 502 FGQVGAGD 525
           FGQ+G  D
Sbjct: 588 FGQLGHSD 595



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 27/100 (27%), Positives = 55/100 (55%)
 Frame = +1

Query: 163 DIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWS 342
           +++ WG G+ G LG GD   R  P  V  ++G +++ +  G  H++ +++   +Y++G +
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586

Query: 343 KYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 462
            +GQLGH DF    VP   +   ++    ++ G  +++ L
Sbjct: 587 TFGQLGHSDFPT-TVPRLAKISSENGVWSVAAGRDYSLFL 625



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 41/152 (26%), Positives = 75/152 (49%), Gaps = 11/152 (7%)
 Frame = +1

Query: 70  LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG---WGRYGNLGLGDRNDRFVPEK 240
           + P+ +  + G +V   A G +H   +TEDG++Y +G   W R G + +   +    P  
Sbjct: 30  ITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICPSS----PIL 84

Query: 241 VSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSS 420
            +++ G  +V VA G  H+  V+ +G  Y +G +  GQ    + +    P+ V ++ DS 
Sbjct: 85  ENALVGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPV-SIADSE 143

Query: 421 TS--------QISGGWRHTMALTSDGKLYGWG 492
            S        Q++ G  HT+AL+   +++ WG
Sbjct: 144 ASPLLAVRILQLACGEEHTLALSISREIWAWG 175



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 23/66 (34%), Positives = 34/66 (51%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
           +WG+ + GQLG G     L P  ++  +G  V  + AG  H+ A+T    +Y WG   +G
Sbjct: 530 TWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFG 589

Query: 196 NLGLGD 213
            LG  D
Sbjct: 590 QLGHSD 595



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 40/134 (29%), Positives = 63/134 (47%), Gaps = 10/134 (7%)
 Frame = +1

Query: 91  AFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPE---------KV 243
           A  G  V  +A G+ H+ AVT++G  Y WG    G   +   N ++VPE         + 
Sbjct: 87  ALVGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVA--NQQYVPEPNPVSIADSEA 144

Query: 244 SSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLV-PHKVEALKDSS 420
           S +   +++ +ACG  HT+ +S S  +  + W    QLG       +  P KVE L    
Sbjct: 145 SPLLAVRILQLACGEEHTLALSISREI--WAWGTGCQLGLITTAFPVTKPQKVEHLAGRV 202

Query: 421 TSQISGGWRHTMAL 462
             Q++ G  H++AL
Sbjct: 203 VLQVACGAFHSLAL 216

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>ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)|
          Length = 1657

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 28/68 (41%), Positives = 39/68 (57%)
 Frame = +1

Query: 322 LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 501
           ++T+G  K GQLGHGD    L P  V+ L       +  G  H++ALT+  ++Y WG N 
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587

Query: 502 FGQVGAGD 525
           FGQ+G  D
Sbjct: 588 FGQLGHSD 595



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 28/100 (28%), Positives = 55/100 (55%)
 Frame = +1

Query: 163 DIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWS 342
           +++ WG G+ G LG GD   R  P  V  ++G +++ +  G  H++ +++   +Y++G +
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586

Query: 343 KYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 462
            +GQLGH DF    VP   +   ++    I+ G  +++ L
Sbjct: 587 TFGQLGHSDFPT-TVPRLAKISSENGVWSIAAGRDYSLFL 625



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 40/152 (26%), Positives = 75/152 (49%), Gaps = 11/152 (7%)
 Frame = +1

Query: 70  LLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWG---WGRYGNLGLGDRNDRFVPEK 240
           + P+ +  + G +V   A G +H   +TEDG++Y +G   W R G + +   +    P  
Sbjct: 30  ITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICPSS----PIL 84

Query: 241 VSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSS 420
            +++ G  ++ VA G  H+  V+ +G  Y +G +  GQ    + +    P+ V ++ DS 
Sbjct: 85  ENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPV-SIADSE 143

Query: 421 TS--------QISGGWRHTMALTSDGKLYGWG 492
            S        Q++ G  HT+AL+   +++ WG
Sbjct: 144 ASPLLAVRILQLACGEEHTLALSISREIWAWG 175



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 23/66 (34%), Positives = 34/66 (51%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
           +WG+ + GQLG G     L P  ++  +G  V  + AG  H+ A+T    +Y WG   +G
Sbjct: 530 TWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFG 589

Query: 196 NLGLGD 213
            LG  D
Sbjct: 590 QLGHSD 595



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 40/134 (29%), Positives = 63/134 (47%), Gaps = 10/134 (7%)
 Frame = +1

Query: 91  AFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPE---------KV 243
           A  G  V  +A G+ H+ AVT++G  Y WG    G   +   N ++VPE         + 
Sbjct: 87  ALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVA--NQQYVPEPNPVSIADSEA 144

Query: 244 SSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLV-PHKVEALKDSS 420
           S +   +++ +ACG  HT+ +S S  +  + W    QLG       +  P KVE L    
Sbjct: 145 SPLLAVRILQLACGEEHTLALSISREI--WAWGTGCQLGLITTAFPVTKPQKVEHLAGRV 202

Query: 421 TSQISGGWRHTMAL 462
             Q++ G  H++AL
Sbjct: 203 VLQVACGAFHSLAL 216

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>ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1651

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 27/65 (41%), Positives = 38/65 (58%)
 Frame = +1

Query: 322 LYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNK 501
           ++T+G  K GQLGHGD    L P  V+ L       +  G  H++ALT+  ++Y WG N 
Sbjct: 522 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNT 581

Query: 502 FGQVG 516
           FGQ+G
Sbjct: 582 FGQLG 586



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 43/153 (28%), Positives = 72/153 (47%), Gaps = 11/153 (7%)
 Frame = +1

Query: 67  SLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEK-- 240
           SL P+ +  + G +V   A G  H   +TEDG++Y      +G L     +    P    
Sbjct: 29  SLTPERLPGWGGKTVLQAALGVRHGVLLTEDGEVYS-----FGTLPWKSESAEICPSSPL 83

Query: 241 -VSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDS 417
             S++ G  ++ VA G  H+  V+ SG +Y +G +  GQ    + +    P  V ++ DS
Sbjct: 84  LESALVGHHVITVATGSFHSGAVTESGVVYMWGENAAGQCAVANQQYVPEPSPV-SISDS 142

Query: 418 STS--------QISGGWRHTMALTSDGKLYGWG 492
            TS        Q++ G  HT+AL+   +++ WG
Sbjct: 143 ETSPSLAVRILQLACGEEHTLALSLSREIWAWG 175



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 26/100 (26%), Positives = 55/100 (55%)
 Frame = +1

Query: 163 DIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWS 342
           +++ WG G+ G LG GD   R  P  V  ++G +++ +  G  H++ +++   +Y++G +
Sbjct: 521 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSN 580

Query: 343 KYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 462
            +GQLGH +F    VP   +   ++    ++ G  +++ L
Sbjct: 581 TFGQLGHSEFPT-TVPRLSKVSSENGVWSVAAGQDYSLFL 619



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 22/63 (34%), Positives = 33/63 (52%)
 Frame = +1

Query: 16  SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
           +WG+ + GQLG G     L P  ++  +G  V  + AG  H+ A+T    +Y WG   +G
Sbjct: 524 TWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNTFG 583

Query: 196 NLG 204
            LG
Sbjct: 584 QLG 586



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/110 (26%), Positives = 47/110 (42%), Gaps = 8/110 (7%)
 Frame = +1

Query: 1   AGXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG-------ISVKMIAAGAEHTAAVTED 159
           +G    WG N  GQ  +   +    P  +   +        + +  +A G EHT A++  
Sbjct: 109 SGVVYMWGENAAGQCAVANQQYVPEPSPVSISDSETSPSLAVRILQLACGEEHTLALSLS 168

Query: 160 GDIYGWGWGRYGNLGLGDRNDRFV-PEKVSSVEGDKMVLVACGWRHTITV 306
            +I  W WG    LGL         P+KV  + G  ++ VACG  H++ +
Sbjct: 169 REI--WAWGTGCQLGLITTTFPVTKPQKVEHLAGRVVLQVACGAFHSLAL 216

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>RCC1_CANAL (P52499) Protein RCC1|
          Length = 464

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 44/175 (25%), Positives = 72/175 (41%), Gaps = 26/175 (14%)
 Frame = +1

Query: 88  QAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGL----GDRNDRFV---PEKVS 246
           Q F   ++K IA+G  H  A+    ++Y WG  +YG   L    G+  D  V   P  + 
Sbjct: 246 QQFGLYNIKYIASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIP 305

Query: 247 SVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLG-----------------HGDFE 375
            +    +  +A G  HT+ ++  G +Y +G     ++G                 HG F 
Sbjct: 306 ELSHKGIKEIAAGEHHTLALTEDGQVYAWGRYDMKEIGIPKDKLPKSTFKINTGTHGSFS 365

Query: 376 --DHLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNAD 534
              +L   K++         I  G  H+ A+T DG +Y WG+ +    G G + D
Sbjct: 366 FLQNLFAVKIKT--------IGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSID 412



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 46/209 (22%), Positives = 76/209 (36%), Gaps = 62/209 (29%)
 Frame = +1

Query: 76  PQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRF----VPEKV 243
           P  ++      +  +AA    +AA+  +GD+Y WG  R     LG   D       P K+
Sbjct: 135 PALVENLPEGEIVQLAATDNLSAALLSNGDVYSWGCFRCNEGLLGFLRDEIKLQKTPLKI 194

Query: 244 SSVE-------GDKMVLVA----------------------------------------- 279
             ++         K++L+A                                         
Sbjct: 195 KELKKHCPIMRSVKIILLALDSKEWMPGVNGQQYQLGRRILERHRYRSLEPQQFGLYNIK 254

Query: 280 ---CGWRHTITVSSSGSLYTYGWSKYGQLG----HGDFEDHLV---PHKVEALKDSSTSQ 429
               G  H   +  S ++Y +G ++YGQ      +G+ ED  V   P  +  L      +
Sbjct: 255 YIASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELSHKGIKE 314

Query: 430 ISGGWRHTMALTSDGKLYGWGWNKFGQVG 516
           I+ G  HT+ALT DG++Y WG     ++G
Sbjct: 315 IAAGEHHTLALTEDGQVYAWGRYDMKEIG 343



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 29/116 (25%), Positives = 55/116 (47%), Gaps = 16/116 (13%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDSLLPQTIQAFEG-------------ISVKMIAAGAEHTA 144
           G   +WGR    ++G+   +D L   T +   G             + +K I  G+ H+ 
Sbjct: 329 GQVYAWGRYDMKEIGI--PKDKLPKSTFKINTGTHGSFSFLQNLFAVKIKTIGVGSHHSF 386

Query: 145 AVTEDGDIYGWGWGRYGNLGLGDR-NDRFVPEKV--SSVEGDKMVLVACGWRHTIT 303
           AVTEDG +Y WG+      GLG   +D   P ++  ++ + + ++L+  G + +++
Sbjct: 387 AVTEDGVVYAWGFAETYGPGLGPSIDDVEKPTRIVNTATKNEDILLIGAGGQFSVS 442



 Score = 37.7 bits (86), Expect = 0.023
 Identities = 38/158 (24%), Positives = 57/158 (36%), Gaps = 38/158 (24%)
 Frame = +1

Query: 133 EHTAAVTEDGDIYGWGWGRYGNLGLGDR-----------NDRFVPEKVSSVEGDKMVLVA 279
           E+  A +   D++ WG G    LGLG             N     EK+    G K+V  A
Sbjct: 15  EYAKAKSTPLDVFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLG---GTKIVDFA 71

Query: 280 CGWRHTITVSSSGSLYTYGWSKYGQLGH--------------------------GDF-ED 378
            G  HT+ +     ++++G +    LG                           GD  E 
Sbjct: 72  VGGMHTLALDGKNRIWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDDDDDDEDGDLNEA 131

Query: 379 HLVPHKVEALKDSSTSQISGGWRHTMALTSDGKLYGWG 492
              P  VE L +    Q++     + AL S+G +Y WG
Sbjct: 132 ESTPALVENLPEGEIVQLAATDNLSAALLSNGDVYSWG 169

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>RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell cycle|
           regulatory protein) (RCC1 homolog)
          Length = 569

 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 49/173 (28%), Positives = 75/173 (43%), Gaps = 23/173 (13%)
 Frame = +1

Query: 109 VKMIAAGAEHTAAVTEDGDIYGWGWGR--YGNLGLGDRNDRF--VPEKVSSVEGDKMVLV 276
           + M+AAGA  TAA+T+ G +  WG  R   GN+ +     +    P  +      K+V +
Sbjct: 246 IVMLAAGASFTAALTDQGSVIAWGNLRNSNGNVDVHPLLHKMQEAPVVIVHQAKRKIVKI 305

Query: 277 ACGWRHTITVSSSGSLYTYGWSKYGQLGHG-------------DFEDHLV-----PHKVE 402
           A G  H + +   G L T+G  + GQLG               +  DHL+      HK +
Sbjct: 306 AAGENHLVMLDEKGCLLTFGDGEMGQLGRSSRTKTIRSKYMCDESGDHLLVPLRFKHKGK 365

Query: 403 ALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAG-DNADHCSPAQVN 558
                + +  + G+  T+    DGK Y +G N + Q+G   D AD     Q N
Sbjct: 366 FFDVVAKNVFASGF-WTIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQDN 417



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 48/209 (22%), Positives = 84/209 (40%), Gaps = 36/209 (17%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGTTEDS--------------LLPQTIQ---AFEGISVKMIAAGA 132
           G  L++G  + GQLG  +   +              L+P   +    F  +  K + A  
Sbjct: 319 GCLLTFGDGEMGQLGRSSRTKTIRSKYMCDESGDHLLVPLRFKHKGKFFDVVAKNVFASG 378

Query: 133 EHTAAVTEDGDIYGWGWGRYGNLGLG--------DRNDR-----FVPEKVSSVEGDKMVL 273
             T    EDG  Y +G   Y  LG+         D  D      F+P +  +   ++  +
Sbjct: 379 FWTIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQDNRELRVFLPAEAPAFGAERTFV 438

Query: 274 VACGWRHTITVSSSGSLYTYGWSKYGQLGHG-----DFEDHLVPHKVEALK-DSSTSQIS 435
              G +H + + S G ++  G +    LG G     D + H +   ++ ++ DS    +S
Sbjct: 439 NIEGVQHVVILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFDSKIVGVS 498

Query: 436 GGWRHTMALTSDGKLYGWGWNKFGQVGAG 522
                ++A + DG  Y WG++  GQ+G G
Sbjct: 499 AKLATSIAWSEDGTAYAWGFDTTGQLGLG 527



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 35/115 (30%), Positives = 60/115 (52%), Gaps = 13/115 (11%)
 Frame = +1

Query: 4   GXXLSWGRNQNGQLGLGT-----TEDSLLPQTIQAFEGISVKMIAAGAEHTAAV--TEDG 162
           G   + G+N +  LGLG       +   L  TIQ  E  S K++   A+   ++  +EDG
Sbjct: 453 GKVFAMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFDS-KIVGVSAKLATSIAWSEDG 511

Query: 163 DIYGWGWGRYGNLGLG--DRNDRFV--PEKVSS--VEGDKMVLVACGWRHTITVS 309
             Y WG+   G LGLG  D +++ V  PE++SS  ++G  ++  +   +HT+ ++
Sbjct: 512 TAYAWGFDTTGQLGLGLKDEDEKMVSKPEEISSAHLDGYSIIGASISDQHTLIIA 566



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 45/177 (25%), Positives = 76/177 (42%), Gaps = 17/177 (9%)
 Frame = +1

Query: 37  GQLGLGTTEDSLLPQTIQAFE--GISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNL--- 201
           G  G  TT+    P+ +  FE  G+      AG  H+A +T +G++Y  G    G +   
Sbjct: 164 GHPGRTTTKK---PRKVDIFEEEGLKPLQAVAGGVHSAVLTSEGEVYMCGINEKGTVPAE 220

Query: 202 -----GLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHG 366
                G  D   +   E+    EG K+V++A G   T  ++  GS+  +G  +     +G
Sbjct: 221 GVEKEGSTDEFAKVKFEEDIEKEG-KIVMLAAGASFTAALTDQGSVIAWGNLRN---SNG 276

Query: 367 DFEDHLVPHKVEALKDSSTSQ-------ISGGWRHTMALTSDGKLYGWGWNKFGQVG 516
           + + H + HK++        Q       I+ G  H + L   G L  +G  + GQ+G
Sbjct: 277 NVDVHPLLHKMQEAPVVIVHQAKRKIVKIAAGENHLVMLDEKGCLLTFGDGEMGQLG 333

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>RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-)|
            (Pam/highwire/rpm-1 protein) (Regulator of presynaptic
            morphology protein 1) (Synapse defective protein 3)
          Length = 3766

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 39/140 (27%), Positives = 61/140 (43%), Gaps = 14/140 (10%)
 Frame = +1

Query: 103  ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC 282
            + V  ++ G  HT  +  D  ++ +G   +G LG+GD   +  P++V       +V VA 
Sbjct: 767  VKVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAA 826

Query: 283  GWRHTITVSSSGSLYTYGWSKYGQLGHGDFED---HLVPHKVEALKDSSTSQISGGW--- 444
            G  HTI  ++ GS++T+G    GQL     E    + +P KV        +    GW   
Sbjct: 827  GSNHTILRANDGSVFTFGAFGKGQLARPAGEKAGWNAIPEKVSGFGPGFNA--FAGWIGA 884

Query: 445  --------RHTMALTSDGKL 480
                     HT  L+SD  L
Sbjct: 885  DGDSSIIHSHTALLSSDNIL 904



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 30/92 (32%), Positives = 51/92 (55%), Gaps = 2/92 (2%)
 Frame = +1

Query: 262  KMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGG 441
            K+  V+CG  HT+ ++S   ++T+G + +GQLG GD      P +V    D+   Q++ G
Sbjct: 768  KVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAAG 827

Query: 442  WRHTMALTSDGKLYGWGWNKFGQVG--AGDNA 531
              HT+   +DG ++ +G    GQ+   AG+ A
Sbjct: 828  SNHTILRANDGSVFTFGAFGKGQLARPAGEKA 859



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 26/80 (32%), Positives = 40/80 (50%), Gaps = 3/80 (3%)
 Frame = +1

Query: 16   SWGRNQNGQLGLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYG 195
            ++G N +GQLG+G T     PQ +       +  +AAG+ HT     DG ++ +G    G
Sbjct: 790  TFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAAGSNHTILRANDGSVFTFGAFGKG 849

Query: 196  NLG--LGDRND-RFVPEKVS 246
             L    G++     +PEKVS
Sbjct: 850  QLARPAGEKAGWNAIPEKVS 869



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 20/51 (39%), Positives = 28/51 (54%)
 Frame = +1

Query: 412 DSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNFP 564
           D   S +S G  HT+ L SD +++ +G N  GQ+G GD     +P QV  P
Sbjct: 766 DVKVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILP 816



 Score = 35.8 bits (81), Expect = 0.087
 Identities = 16/62 (25%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
 Frame = +1

Query: 28  NQNGQL---GLGTTEDSLLPQTIQAFEGISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGN 198
           ++NG++   GL T   ++  Q +   + + +  +A G  H  AVT +G ++ WG      
Sbjct: 585 SENGKIFMGGLHTMRVNVSSQMLNGLDNVMISSLALGKSHGVAVTRNGHLFTWGLNNMNQ 644

Query: 199 LG 204
            G
Sbjct: 645 CG 646

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>FBX24_HUMAN (O75426) F-box only protein 24|
          Length = 580

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 29/90 (32%), Positives = 44/90 (48%), Gaps = 12/90 (13%)
 Frame = +1

Query: 82  TIQAFEGISVKM------------IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDR 225
           T+QAF+ +  +M             A G  H   V E G I+  G  RYG LG GD+ DR
Sbjct: 338 TLQAFDPLDQQMPLALSLPAKILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDR 397

Query: 226 FVPEKVSSVEGDKMVLVACGWRHTITVSSS 315
             P +V  ++  + + + CG  H++ +S S
Sbjct: 398 GEPTQVCYLQ--RPITLWCGLNHSLVLSQS 425



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 35/131 (26%), Positives = 58/131 (44%), Gaps = 6/131 (4%)
 Frame = +1

Query: 103 ISVKMIAAGAEHTAAVTEDGDIY------GWGWGRYGNLGLGDRNDRFVPEKVSSVEGDK 264
           + V  + +    T  VT+ G +Y      G     +G L   D  D+ +P  +S     K
Sbjct: 301 LRVACMTSNQSSTLYVTDQGGVYFEVHTPGVYRDLFGTLQAFDPLDQQMPLALSLPA--K 358

Query: 265 MVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGW 444
           ++  A G+ H   V   G ++  G ++YGQLG GD  D   P +V  L+   T  +  G 
Sbjct: 359 ILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYLQRPIT--LWCGL 416

Query: 445 RHTMALTSDGK 477
            H++ L+   +
Sbjct: 417 NHSLVLSQSSE 427



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 14/39 (35%), Positives = 22/39 (56%)
 Frame = +1

Query: 439 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQV 555
           G+ H   +   G+++  G N++GQ+G GD  D   P QV
Sbjct: 365 GYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQV 403

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>FBX24_MOUSE (Q9D417) F-box only protein 24|
          Length = 589

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 12/90 (13%)
 Frame = +1

Query: 82  TIQAFEGISVKM------------IAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDR 225
           T+QAF+ +  +M             A G  H   V E G I+  G  RYG LG GD+ DR
Sbjct: 348 TLQAFDPLDHQMPLALSLPAKVLFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDR 407

Query: 226 FVPEKVSSVEGDKMVLVACGWRHTITVSSS 315
             P +V  ++  + + + CG  H++ +S +
Sbjct: 408 GEPTQVHYLQ--RPIALWCGLNHSLVLSQT 435



 Score = 36.6 bits (83), Expect = 0.051
 Identities = 34/115 (29%), Positives = 50/115 (43%), Gaps = 15/115 (13%)
 Frame = +1

Query: 190 YGNLGLGDRNDRFVPEKVSSVEGDKMVLVACGWRHTITVSSSGSLYTYGWSKYGQLGHGD 369
           +G L   D  D  +P  +S     K++  A G+ H   V   G ++  G ++YGQLG GD
Sbjct: 346 FGTLQAFDPLDHQMPLALSLPA--KVLFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGD 403

Query: 370 FEDHLVPHKVEALKDSSTSQISGGWRHTMAL--TSD-------------GKLYGW 489
             D   P +V  L+      +  G  H++ L  TSD             G+L GW
Sbjct: 404 KMDRGEPTQVHYLQ--RPIALWCGLNHSLVLSQTSDFSKELLGCGCGAGGRLPGW 456



 Score = 35.8 bits (81), Expect = 0.087
 Identities = 14/41 (34%), Positives = 24/41 (58%)
 Frame = +1

Query: 439 GWRHTMALTSDGKLYGWGWNKFGQVGAGDNADHCSPAQVNF 561
           G+ H   +   G+++  G N++GQ+G GD  D   P QV++
Sbjct: 375 GYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVHY 415

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>YB9W_YEAST (P38352) F-box protein YBR280C|
          Length = 637

 Score = 33.1 bits (74), Expect = 0.56
 Identities = 22/60 (36%), Positives = 34/60 (56%), Gaps = 3/60 (5%)
 Frame = +1

Query: 106 SVKMIAAGAEHTAAVTEDGDIYGWGWGRY--GNLGLGDRNDRFVPE-KVSSVEGDKMVLV 276
           +V  +A+G  HT A+TE G +Y WG      G LGLG  +++ V E  + + EG + + V
Sbjct: 547 NVISVASGDYHTVALTERGHLYSWGIESQDCGCLGLGP-SEKIVNELHIGNWEGQRNIRV 605

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>PWP2_SCHPO (Q9C1X1) Periodic tryptophan protein 2 homolog|
          Length = 854

 Score = 32.3 bits (72), Expect = 0.96
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 1/69 (1%)
 Frame = +1

Query: 295 TITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDS-STSQISGGWRHTMALTSD 471
           T+TV+S+G     G SK GQL   +++      K ++  D+ ST Q S   +  +    D
Sbjct: 301 TLTVNSTGDWIAIGSSKLGQLLVWEWQSESYVLKQQSHYDALSTLQYSSDGQRIITGADD 360

Query: 472 GKLYGWGWN 498
           GK+  W  N
Sbjct: 361 GKIKVWDMN 369

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>HYD_DROME (P51592) Ubiquitin--protein ligase hyd (EC 6.3.2.-) (Protein|
           hyperplastic discs)
          Length = 2885

 Score = 31.6 bits (70), Expect = 1.6
 Identities = 31/136 (22%), Positives = 57/136 (41%)
 Frame = +1

Query: 103 ISVKMIAAGAEHTAAVTEDGDIYGWGWGRYGNLGLGDRNDRFVPEKVSSVEGDKMVLVAC 282
           +  K I A      A++E GD+Y W W         +  + + P+ VS    +++ L++ 
Sbjct: 361 VRFKTIGALYSEFIALSESGDLYQWRWSD-AEPYKSETENVYHPKTVSLNIVERVELISA 419

Query: 283 GWRHTITVSSSGSLYTYGWSKYGQLGHGDFEDHLVPHKVEALKDSSTSQISGGWRHTMAL 462
            +     V+ +  + T+   + G +G     +H      E + DS T +I     +T+  
Sbjct: 420 NFIRCSVVTETNRVATWMDEQLGYIGAK--LEHSCCAFNEFISDSIT-KIYVCSLYTVVK 476

Query: 463 TSDGKLYGWGWNKFGQ 510
           T    +Y WG   F Q
Sbjct: 477 TESNNIYWWGVLPFDQ 492

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>HCN1_RABIT (Q9MZS1) Potassium/sodium hyperpolarization-activated cyclic|
           nucleotide-gated channel 1 (rbHCN1)
          Length = 822

 Score = 31.2 bits (69), Expect = 2.1
 Identities = 18/45 (40%), Positives = 22/45 (48%)
 Frame = -2

Query: 260 SPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAP 126
           SP      S ++ +  SP P     PQP   +SP S T AVCS P
Sbjct: 600 SPPVYTATSLSHSNLHSPSPS-TQTPQPSAILSPCSYTTAVCSPP 643

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>HCN1_RAT (Q9JKB0) Potassium/sodium hyperpolarization-activated cyclic|
           nucleotide-gated channel 1
          Length = 910

 Score = 31.2 bits (69), Expect = 2.1
 Identities = 18/45 (40%), Positives = 22/45 (48%)
 Frame = -2

Query: 260 SPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAP 126
           SP      S ++ +  SP P     PQP   +SP S T AVCS P
Sbjct: 653 SPPVYTATSLSHSNLHSPSPS-TQTPQPSAILSPCSYTTAVCSPP 696

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>HCN1_MOUSE (O88704) Potassium/sodium hyperpolarization-activated cyclic|
           nucleotide-gated channel 1 (Brain cyclic nucleotide
           gated channel 1) (BCNG-1) (Hyperpolarization-activated
           cation channel 2) (HAC-2)
          Length = 910

 Score = 31.2 bits (69), Expect = 2.1
 Identities = 18/45 (40%), Positives = 22/45 (48%)
 Frame = -2

Query: 260 SPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAP 126
           SP      S ++ +  SP P     PQP   +SP S T AVCS P
Sbjct: 653 SPPVYTATSLSHSNLHSPSPS-TQTPQPSAILSPCSYTTAVCSPP 696

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>HCN1_HUMAN (O60741) Potassium/sodium hyperpolarization-activated cyclic|
           nucleotide-gated channel 1 (Brain cyclic nucleotide
           gated channel 1) (BCNG-1)
          Length = 890

 Score = 31.2 bits (69), Expect = 2.1
 Identities = 18/45 (40%), Positives = 22/45 (48%)
 Frame = -2

Query: 260 SPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPSSVTAAVCSAP 126
           SP      S ++ +  SP P     PQP   +SP S T AVCS P
Sbjct: 664 SPPVYTATSLSHSNLHSPSPS-TQTPQPSAILSPCSYTTAVCSPP 707

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>FREM2_LYTVA (Q9GV77) Extracellular matrix protein 3 precursor (FREM2 homolog)|
          Length = 3103

 Score = 30.8 bits (68), Expect = 2.8
 Identities = 15/48 (31%), Positives = 24/48 (50%)
 Frame = +2

Query: 410  RIALHPRFQVDGGTQWHLHQMENFMDGDGTSLGKLELAIMLITVPQPR 553
            R+A    F+VD G  W+LH + +    + + +GK E     I+  Q R
Sbjct: 2955 RLASDALFEVDYGRTWYLHSIYSMRSSESSGIGKRETEHHAISSRQRR 3002

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>VGLD_PRVRI (P07645) Protein gp50|
          Length = 402

 Score = 30.8 bits (68), Expect = 2.8
 Identities = 15/43 (34%), Positives = 22/43 (51%)
 Frame = -2

Query: 284 PHATSTILSPSTEDTFSGTNRSFRSPRPKFPYRPQPHP*ISPS 156
           P     +  P+T D  +G   + R PRP+ P+RP   P + PS
Sbjct: 288 PAPPDRLPEPATRDHAAGGRPTPRPPRPETPHRPFAPPAVVPS 330

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>KLPA_EMENI (P28739) Kinesin-like protein klpA|
          Length = 770

 Score = 30.4 bits (67), Expect = 3.6
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 5/42 (11%)
 Frame = +1

Query: 346 YGQLGHGDFE-----DHLVPHKVEALKDSSTSQISGGWRHTM 456
           YGQ G G        D ++P  V  + +++TS    GWR+TM
Sbjct: 513 YGQTGSGKTHTMSSLDGMIPRAVHQIYETATSLEEKGWRYTM 554

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>MUC_CHICK (P01875) Ig mu chain C region|
          Length = 446

 Score = 30.0 bits (66), Expect = 4.8
 Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 1/42 (2%)
 Frame = -2

Query: 503 NLFHPHP*SFPSDVSAIVCLHPPEIWDVELSFK-ASTLCGTR 381
           ++ +P P   P+ +   V +HPP   D E  F+ AS LC TR
Sbjct: 97  SVMNPGPIPTPNGIPLFVTMHPPSREDFEGPFRNASILCQTR 138

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>LOXC_ARATH (P38418) Lipoxygenase, chloroplast precursor (EC 1.13.11.12)|
          Length = 896

 Score = 29.6 bits (65), Expect = 6.2
 Identities = 14/45 (31%), Positives = 24/45 (53%)
 Frame = +1

Query: 400 EALKDSSTSQISGGWRHTMALTSDGKLYGWGWNKFGQVGAGDNAD 534
           +A+K+  T  +   +     +TSD +L GW W++   +G GD  D
Sbjct: 675 DAIKEWVTDYVKHYYPDEELITSDEELQGW-WSEVRNIGHGDKKD 718

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>PLDP1_ARATH (Q9LRZ5) Phospholipase D p1 (EC 3.1.4.4) (AtPLDp1) (Phospholipase|
           D1 PHOX and PX containing domain) (Phospholipase D zeta
           1) (PLDzeta1)
          Length = 1096

 Score = 29.3 bits (64), Expect = 8.1
 Identities = 8/18 (44%), Positives = 11/18 (61%)
 Frame = +3

Query: 120 CCWCRTYCCSN*RWRYLW 173
           CC C  +CC N  W+ +W
Sbjct: 239 CCGCCWFCCCNDNWQKVW 256


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.315    0.135    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,728,893
Number of Sequences: 219361
Number of extensions: 2012017
Number of successful extensions: 5654
Number of sequences better than 10.0: 61
Number of HSP's better than 10.0 without gapping: 4720
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5306
length of database: 80,573,946
effective HSP length: 106
effective length of database: 57,321,680
effective search space used: 4700377760
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)

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full-length cDNA and EST

Clone Information

BLAST Search Result