ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | baalj04 |
|---|---|
| Clone Library Name | barley_pub |
>KC1_TOXGO (Q6QNM1) Casein kinase I (EC 2.7.11.1)| Length = 324 Score = 135 bits (341), Expect = 7e-32 Identities = 70/178 (39%), Positives = 113/178 (63%) Frame = +3 Query: 78 VQIGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPY 257 V++GG +YR+ RK+G G FG +++G + G+ EVAIK E SK Y Sbjct: 3 VRVGG--KYRLGRKIGSGSFGDIYIGANILTGD-------EVAIKLESIKSKHPQL--LY 51 Query: 258 EWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAE 437 E +Y L G G+P VH+ G +GDY VM++D+LGPSL D +++ + +S + V +A + Sbjct: 52 ESKLYKLLAGGIGIPMVHWYGIEGDYNVMVIDLLGPSLEDLFSICNRKLSLKTVLMLADQ 111 Query: 438 AISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 ++ +E +HSK ++H D+KP+NFL+G+ + ++++D GLA K++DP TQQH+ Y Sbjct: 112 MLNRIEFVHSKNFIHRDIKPDNFLIGR--GKKMSVVYIIDFGLAKKYRDPKTQQHIPY 167
>KC12_YEAST (P23292) Casein kinase I homolog 2 (EC 2.7.11.1)| Length = 546 Score = 131 bits (329), Expect = 2e-30 Identities = 60/173 (34%), Positives = 108/173 (62%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 Y++ +K+G+G FG +F G + G VAIKFE ++ E+ Y L Sbjct: 76 YKIGKKIGEGSFGVLFEGTNMING-------LPVAIKFEPRKTEAPQLKD--EYRTYKIL 126 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 GT G+P+ +Y G++G + ++++D+LGPSL D ++ G+ S + V +A + I+++E + Sbjct: 127 AGTPGIPQEYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAVQMITLIEDL 186 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQR 620 H+ ++ D+KP+NFL+G+PG P K+ L+D G+A +++DP T+QH+ Y ++ Sbjct: 187 HAHDLIYRDIKPDNFLIGRPGQPDANKVHLIDFGMAKQYRDPKTKQHIPYREK 239
>CKI2_SCHPO (P40234) Casein kinase I homolog 2 (EC 2.7.11.1)| Length = 435 Score = 128 bits (322), Expect = 1e-29 Identities = 64/173 (36%), Positives = 104/173 (60%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 YRV RK+G+G FG +F G L Q +AIKFE S+ E+ Y L Sbjct: 12 YRVGRKIGEGSFGVIFDGMNLLNN-------QLIAIKFEPKKSEAPQLRD--EYRTYKLL 62 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 G G+P V+Y G++G + ++++D+LGPSL D + G+ S + VA A + +S ++++ Sbjct: 63 VGNAGIPNVYYFGQEGLHNILVIDLLGPSLEDLFEWCGRRFSVKTVAMTAKQMLSRVQTI 122 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQR 620 H K V+ D+KP+NFL+G+P + +++VD G+A ++DP T+QH+ Y +R Sbjct: 123 HEKNLVYRDIKPDNFLIGRPSSRNANMVYMVDFGMAKYYRDPKTKQHIPYSER 175
>CKI3_SCHPO (O74135) Casein kinase I homolog 3 (EC 2.7.11.1)| Length = 439 Score = 127 bits (319), Expect = 3e-29 Identities = 64/172 (37%), Positives = 105/172 (61%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 YRV +K+G+G FG +F G L Q +A+KFE S+ E+ Y L Sbjct: 15 YRVGKKIGEGSFGMLFQGVNLINN-------QPIALKFESRKSEVPQLRD--EYLTYKLL 65 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 G G+P V+Y G++G Y +++MD+LGPSL D ++ G+ S + VA IA + I+ ++S+ Sbjct: 66 MGLPGIPSVYYYGQEGMYNLLVMDLLGPSLEDLFDYCGRRFSPKTVAMIAKQMITRIQSV 125 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQ 617 H + +++ D+KP+NFL+G PG+ E ++ VD G+A +++DP T H Y++ Sbjct: 126 HERHFIYRDIKPDNFLIGFPGSKTENVIYAVDFGMAKQYRDPKTHVHRPYNE 177
>CKI1_SCHPO (P40233) Casein kinase I homolog 1 (EC 2.7.11.1)| Length = 446 Score = 127 bits (319), Expect = 3e-29 Identities = 62/173 (35%), Positives = 104/173 (60%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 Y+V R++G+G FG +F G L Q+VAIKFE S E+ Y L Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNN-------QQVAIKFEPRRSDAPQLRD--EYRTYKLL 62 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 G G+P V+Y G++G + ++++D+LGPSL D +L G+ S + VA A + ++ ++S+ Sbjct: 63 AGCTGIPNVYYFGQEGLHNILVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSI 122 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQR 620 H K V+ D+KP+NFL+G+P + +++VD G+ ++DP T+QH+ Y ++ Sbjct: 123 HEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREK 175
>KC11_YEAST (P23291) Casein kinase I homolog 1 (EC 2.7.11.1)| Length = 538 Score = 127 bits (318), Expect = 3e-29 Identities = 58/173 (33%), Positives = 105/173 (60%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 Y++ +K+G+G FG +F G + G VAIKFE ++ Y+ Y L Sbjct: 69 YKIGKKIGEGSFGVLFEGTNMING-------VPVAIKFEPRKTEAPQLRDEYK--TYKIL 119 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 GT +P +Y G++G + ++++D+LGPSL D ++ G+ S + V +A + I+++E + Sbjct: 120 NGTPNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDL 179 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQR 620 H+ ++ D+KP+NFL+G+PG P + L+D G+A +++DP T+QH+ Y ++ Sbjct: 180 HAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREK 232
>KC1B_BOVIN (P35507) Casein kinase I isoform beta (EC 2.7.11.1) (CKI-beta)| Length = 336 Score = 125 bits (315), Expect = 8e-29 Identities = 69/178 (38%), Positives = 109/178 (61%) Frame = +3 Query: 78 VQIGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPY 257 V +GG Y++ R++G G FGHV++ LT ++VA+K E ++ + Sbjct: 11 VLVGG--RYKLVREIGFGSFGHVYLAIDLTNH-------EQVAVKLESENTRQPRL--LH 59 Query: 258 EWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAE 437 E +Y+ L G G+P++ + G++ DY V++MD+LGPSL D +N + S + V +A + Sbjct: 60 EKELYNFLQGGVGIPQIRWYGQETDYNVLVMDLLGPSLEDLFNFCSRRFSMKTVLMLADQ 119 Query: 438 AISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 IS +E +HS+ +H D+KP+NFL+G PQ KKLFLVD GLA K++D T QH+ + Sbjct: 120 MISRIEYVHSRNLIHRDIKPDNFLMGT--GPQWKKLFLVDFGLAKKYRDNRTGQHIPH 175
>KC1G3_HUMAN (Q9Y6M4) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) Length = 447 Score = 125 bits (314), Expect = 1e-28 Identities = 66/172 (38%), Positives = 103/172 (59%) Frame = +3 Query: 96 PEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 P +RV +K+G G FG + +G+ L + VAIK E S+ E+ Y Sbjct: 41 PNFRVGKKIGCGNFGELRLGKNLYTN-------EYVAIKLEPMKSRAPQLH--LEYRFYK 91 Query: 276 ALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 LG G+P+V+Y G G Y M++++LGPSL D ++L +T S + V IA + IS +E Sbjct: 92 QLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRME 151 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 +HSK ++ DVKPENFL+G+PG ++ + ++D GLA ++ DP T++H+ Y Sbjct: 152 YVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPY 203
>KC1G3_RAT (Q62763) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) Length = 448 Score = 125 bits (314), Expect = 1e-28 Identities = 66/172 (38%), Positives = 103/172 (59%) Frame = +3 Query: 96 PEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 P +RV +K+G G FG + +G+ L + VAIK E S+ E+ Y Sbjct: 41 PNFRVGKKIGCGNFGELRLGKNLYTN-------EYVAIKLEPMKSRAPQLH--LEYRFYK 91 Query: 276 ALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 LG G+P+V+Y G G Y M++++LGPSL D ++L +T S + V IA + IS +E Sbjct: 92 QLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRME 151 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 +HSK ++ DVKPENFL+G+PG ++ + ++D GLA ++ DP T++H+ Y Sbjct: 152 YVHSKNLIYRDVKPENFLIGRPGNKAQQVIHIIDFGLAKEYIDPETKKHIPY 203
>KC1G3_BOVIN (P35509) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) (Fragment) Length = 276 Score = 125 bits (314), Expect = 1e-28 Identities = 66/172 (38%), Positives = 103/172 (59%) Frame = +3 Query: 96 PEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 P +RV +K+G G FG + +G+ L + VAIK E S+ E+ Y Sbjct: 27 PNFRVGKKIGCGNFGELRLGKNLYTN-------EYVAIKLEPMKSRAPQLH--LEYRFYK 77 Query: 276 ALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 LG G+P+V+Y G G Y M++++LGPSL D ++L +T S + V IA + IS +E Sbjct: 78 QLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRME 137 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 +HSK ++ DVKPENFL+G+PG ++ + ++D GLA ++ DP T++H+ Y Sbjct: 138 YVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPY 189
>KC1_EIMTE (Q6QNL9) Casein kinase I (EC 2.7.11.1)| Length = 335 Score = 125 bits (313), Expect = 1e-28 Identities = 66/178 (37%), Positives = 112/178 (62%) Frame = +3 Query: 78 VQIGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPY 257 V++GG +YR+ RK+G G FG +++G ++ G+ EVAIK E S+ Y Sbjct: 3 VRVGG--KYRLGRKIGSGSFGDIYLGTNISTGD-------EVAIKLESVRSRHPQL--IY 51 Query: 258 EWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAE 437 E +Y L G G+P +++ G +GDY VMI+++LGPSL D +++ + +S + V +A + Sbjct: 52 ESKLYKILTGGIGIPTLYWYGIEGDYNVMIIELLGPSLEDLFSICNRKLSLKTVLMLADQ 111 Query: 438 AISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 ++ +E +HS+ ++H D+KP+NFL+G+ + +F +D GLA K++DP TQ H+ Y Sbjct: 112 MLNRIEFVHSRHFIHRDIKPDNFLIGR--GKKMSIVFAIDFGLAKKYRDPRTQSHIPY 167
>KC1G2_HUMAN (P78368) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 124 bits (312), Expect = 2e-28 Identities = 65/172 (37%), Positives = 104/172 (60%) Frame = +3 Query: 96 PEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 P +RV +K+G G FG + +G+ L + VAIK E S+ E+ Y Sbjct: 44 PNFRVGKKIGCGNFGELRLGKNLYTN-------EYVAIKLEPIKSRAPQLH--LEYRFYK 94 Query: 276 ALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 L T GVP+V+Y G G Y M++++LGPSL D ++L +T + + V IA + I+ +E Sbjct: 95 QLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRME 154 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 +H+K ++ DVKPENFL+G+PGT ++ + ++D GLA ++ DP T++H+ Y Sbjct: 155 YVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPY 206
>KC1A_SHEEP (P67829) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 124 bits (310), Expect = 3e-28 Identities = 66/176 (37%), Positives = 107/176 (60%) Frame = +3 Query: 84 IGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW 263 +GG +Y++ RK+G G FG +++ +T G +EVA+K E + K + YE Sbjct: 13 VGG--KYKLVRKIGSGSFGDIYLAINITNG-------EEVAVKLE--SQKARHPQLLYES 61 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +Y L G G+P + + G++ DY V++MD+LGPSL D +N + + + V +A + I Sbjct: 62 KLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMI 121 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 S +E +H+K ++H D+KP+NFL+G KLFL+D GLA K++D T+QH+ Y Sbjct: 122 SRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDNRTRQHIPY 175
>KC1A_RABIT (P67828) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 124 bits (310), Expect = 3e-28 Identities = 66/176 (37%), Positives = 107/176 (60%) Frame = +3 Query: 84 IGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW 263 +GG +Y++ RK+G G FG +++ +T G +EVA+K E + K + YE Sbjct: 13 VGG--KYKLVRKIGSGSFGDIYLAINITNG-------EEVAVKLE--SQKARHPQLLYES 61 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +Y L G G+P + + G++ DY V++MD+LGPSL D +N + + + V +A + I Sbjct: 62 KLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMI 121 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 S +E +H+K ++H D+KP+NFL+G KLFL+D GLA K++D T+QH+ Y Sbjct: 122 SRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDNRTRQHIPY 175
>KC1A_BOVIN (P67827) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 124 bits (310), Expect = 3e-28 Identities = 66/176 (37%), Positives = 107/176 (60%) Frame = +3 Query: 84 IGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW 263 +GG +Y++ RK+G G FG +++ +T G +EVA+K E + K + YE Sbjct: 13 VGG--KYKLVRKIGSGSFGDIYLAINITNG-------EEVAVKLE--SQKARHPQLLYES 61 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +Y L G G+P + + G++ DY V++MD+LGPSL D +N + + + V +A + I Sbjct: 62 KLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMI 121 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 S +E +H+K ++H D+KP+NFL+G KLFL+D GLA K++D T+QH+ Y Sbjct: 122 SRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDNRTRQHIPY 175
>KC1A_XENLA (P67963) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 124 bits (310), Expect = 3e-28 Identities = 66/176 (37%), Positives = 107/176 (60%) Frame = +3 Query: 84 IGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW 263 +GG +Y++ RK+G G FG +++ +T G +EVA+K E + K + YE Sbjct: 13 VGG--KYKLVRKIGSGSFGDIYLAINITNG-------EEVAVKLE--SQKARHPQLLYES 61 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +Y L G G+P + + G++ DY V++MD+LGPSL D +N + + + V +A + I Sbjct: 62 KLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMI 121 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 S +E +H+K ++H D+KP+NFL+G KLFL+D GLA K++D T+QH+ Y Sbjct: 122 SRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDNRTRQHIPY 175
>KC1A_MOUSE (Q8BK63) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 124 bits (310), Expect = 3e-28 Identities = 66/176 (37%), Positives = 107/176 (60%) Frame = +3 Query: 84 IGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW 263 +GG +Y++ RK+G G FG +++ +T G +EVA+K E + K + YE Sbjct: 13 VGG--KYKLVRKIGSGSFGDIYLAINITNG-------EEVAVKLE--SQKARHPQLLYES 61 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +Y L G G+P + + G++ DY V++MD+LGPSL D +N + + + V +A + I Sbjct: 62 KLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMI 121 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 S +E +H+K ++H D+KP+NFL+G KLFL+D GLA K++D T+QH+ Y Sbjct: 122 SRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDNRTRQHIPY 175
>KC1A_HUMAN (P48729) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 124 bits (310), Expect = 3e-28 Identities = 66/176 (37%), Positives = 107/176 (60%) Frame = +3 Query: 84 IGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW 263 +GG +Y++ RK+G G FG +++ +T G +EVA+K E + K + YE Sbjct: 13 VGG--KYKLVRKIGSGSFGDIYLAINITNG-------EEVAVKLE--SQKARHPQLLYES 61 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +Y L G G+P + + G++ DY V++MD+LGPSL D +N + + + V +A + I Sbjct: 62 KLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMI 121 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 S +E +H+K ++H D+KP+NFL+G KLFL+D GLA K++D T+QH+ Y Sbjct: 122 SRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDNRTRQHIPY 175
>KC1A_CHICK (P67962) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 124 bits (310), Expect = 3e-28 Identities = 66/176 (37%), Positives = 107/176 (60%) Frame = +3 Query: 84 IGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW 263 +GG +Y++ RK+G G FG +++ +T G +EVA+K E + K + YE Sbjct: 13 VGG--KYKLVRKIGSGSFGDIYLAINITNG-------EEVAVKLE--SQKARHPQLLYES 61 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +Y L G G+P + + G++ DY V++MD+LGPSL D +N + + + V +A + I Sbjct: 62 KLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMI 121 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 S +E +H+K ++H D+KP+NFL+G KLFL+D GLA K++D T+QH+ Y Sbjct: 122 SRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDNRTRQHIPY 175
>KC1AL_HUMAN (Q8N752) Casein kinase I isoform alpha-like (EC 2.7.11.1)| (CKI-alpha-like) (CK1) Length = 337 Score = 124 bits (310), Expect = 3e-28 Identities = 68/176 (38%), Positives = 106/176 (60%) Frame = +3 Query: 84 IGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW 263 +GG +Y++ RK+G G FG V++G T G +EVA+K E K YE Sbjct: 13 VGG--KYKLVRKIGSGSFGDVYLGITTTNG-------EEVAVKLESQKVKHPQL--LYES 61 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +Y+ L G G+P +H+ G++ D V++MD+LGPSL D +N + + + V +A + I Sbjct: 62 KLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMI 121 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 S +E +H+K ++H D+KP+NFL+G KLFL+D GLA K++D T+QH+ Y Sbjct: 122 SRIEYVHTKNFLHRDIKPDNFLMGT--GRHCNKLFLIDFGLAKKYRDNRTRQHIPY 175
>KC1G2_RAT (Q62762) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 122 bits (307), Expect = 7e-28 Identities = 64/172 (37%), Positives = 104/172 (60%) Frame = +3 Query: 96 PEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 P +RV +K+G G FG + +G+ L + VAIK E S+ E+ Y Sbjct: 44 PNFRVGKKIGCGNFGELRLGKNLYTN-------EYVAIKLEPIKSRAPQLH--LEYRFYK 94 Query: 276 ALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 L T GVP+V+Y G G Y M++++LGPSL D ++L +T + + V IA + I+ +E Sbjct: 95 QLSTTEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRME 154 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 +H+K ++ DVKPENFL+G+PG+ ++ + ++D GLA ++ DP T++H+ Y Sbjct: 155 YVHTKSLIYRDVKPENFLVGRPGSKRQHSIHIIDFGLAKEYIDPETKKHIPY 206
>KC1G2_MOUSE (Q8BVP5) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 122 bits (307), Expect = 7e-28 Identities = 64/172 (37%), Positives = 104/172 (60%) Frame = +3 Query: 96 PEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 P +RV +K+G G FG + +G+ L + VAIK E S+ E+ Y Sbjct: 44 PNFRVGKKIGCGNFGELRLGKNLYTN-------EYVAIKLEPIKSRAPQLH--LEYRFYK 94 Query: 276 ALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 L T GVP+V+Y G G Y M++++LGPSL D ++L +T + + V IA + I+ +E Sbjct: 95 QLSTTEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRME 154 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 +H+K ++ DVKPENFL+G+PG+ ++ + ++D GLA ++ DP T++H+ Y Sbjct: 155 YVHTKSLIYRDVKPENFLVGRPGSKRQHSIHIIDFGLAKEYIDPETKKHIPY 206
>KC1A_RAT (P97633) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 122 bits (306), Expect = 9e-28 Identities = 66/176 (37%), Positives = 106/176 (60%) Frame = +3 Query: 84 IGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW 263 +GG +Y++ RK+G G FG +++ +T G +EVA+K E + K + YE Sbjct: 13 VGG--KYKLVRKIGSGSFGDIYLAINITNG-------EEVAVKLE--SQKARHPQLLYES 61 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +Y L G G+P + + G+ DY V++MD+LGPSL D +N + + + V +A + I Sbjct: 62 KLYKILQGGVGIPHIRWYGQGKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMI 121 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 S +E +H+K ++H D+KP+NFL+G KLFL+D GLA K++D T+QH+ Y Sbjct: 122 SRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDNRTRQHIPY 175
>HHP1_SCHPO (P40235) Casein kinase I homolog hhp1 (EC 2.7.11.1)| Length = 365 Score = 121 bits (303), Expect = 2e-27 Identities = 65/171 (38%), Positives = 100/171 (58%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +YR+ RK+G G FG +++G + G +EVAIK E +K YE+ VY Sbjct: 10 KYRIGRKIGSGSFGDIYLGTNVVSG-------EEVAIKLESTRAKHPQL--EYEYRVYRI 60 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 L G G+P V + G + DY M+MD+LGPSL D +N + S + V +A + IS +E Sbjct: 61 LSGGVGIPFVRWFGVECDYNAMVMDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEF 120 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 +HSK ++H D+KP+NFL+G + ++ ++D GLA K++D T H+ Y Sbjct: 121 IHSKSFLHRDIKPDNFLMGI--GKRGNQVNIIDFGLAKKYRDHKTHLHIPY 169
>KC1D_RAT (Q06486) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| Length = 415 Score = 120 bits (302), Expect = 2e-27 Identities = 64/170 (37%), Positives = 100/170 (58%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 YR+ RK+G G FG +++G + G +EVAIK E +K E +Y + Sbjct: 9 YRLGRKIGSGSFGDIYLGTDIAAG-------EEVAIKLECVKTKHPQLH--IESKIYKMM 59 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 G G+P + + G +GDY VM+M++LGPSL D +N + S + V +A + IS +E + Sbjct: 60 QGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYI 119 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 HSK ++H DVKP+NFL+G + ++++D GLA K++D T QH+ Y Sbjct: 120 HSKNFIHRDVKPDNFLMGL--GKKGNLVYIIDFGLAKKYRDARTHQHIPY 167
>KC1D_MOUSE (Q9DC28) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) Length = 415 Score = 120 bits (302), Expect = 2e-27 Identities = 64/170 (37%), Positives = 100/170 (58%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 YR+ RK+G G FG +++G + G +EVAIK E +K E +Y + Sbjct: 9 YRLGRKIGSGSFGDIYLGTDIAAG-------EEVAIKLECVKTKHPQLH--IESKIYKMM 59 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 G G+P + + G +GDY VM+M++LGPSL D +N + S + V +A + IS +E + Sbjct: 60 QGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYI 119 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 HSK ++H DVKP+NFL+G + ++++D GLA K++D T QH+ Y Sbjct: 120 HSKNFIHRDVKPDNFLMGL--GKKGNLVYIIDFGLAKKYRDARTHQHIPY 167
>KC1D_HUMAN (P48730) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) Length = 415 Score = 120 bits (302), Expect = 2e-27 Identities = 64/170 (37%), Positives = 100/170 (58%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 YR+ RK+G G FG +++G + G +EVAIK E +K E +Y + Sbjct: 9 YRLGRKIGSGSFGDIYLGTDIAAG-------EEVAIKLECVKTKHPQLH--IESKIYKMM 59 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 G G+P + + G +GDY VM+M++LGPSL D +N + S + V +A + IS +E + Sbjct: 60 QGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYI 119 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 HSK ++H DVKP+NFL+G + ++++D GLA K++D T QH+ Y Sbjct: 120 HSKNFIHRDVKPDNFLMGL--GKKGNLVYIIDFGLAKKYRDARTHQHIPY 167
>RAG8_KLULA (P40230) Casein kinase I homolog RAG8 (EC 2.7.11.1)| Length = 536 Score = 120 bits (302), Expect = 2e-27 Identities = 56/173 (32%), Positives = 102/173 (58%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 Y++ +K+G+G FG +F G + VAIKFE + E+ Y L Sbjct: 77 YKIGKKIGEGSFGVLFEGVNMINN-------VPVAIKFEPRKTDAPQLKD--EYRTYKIL 127 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 G+ G+P+ +Y G++G + ++++D+LGPSL D ++ G+ S + V +A + I+++E + Sbjct: 128 SGSEGIPQAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSIKTVVHVAIQMITLIEEL 187 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQR 620 H ++ D+KP+NFL+G+P P + L+D G+A ++DP T+QH+ Y ++ Sbjct: 188 HDHDLIYRDIKPDNFLIGRPNQPDANMVHLIDFGMAKLYRDPKTKQHIPYREK 240
>KC1E_MOUSE (Q9JMK2) Casein kinase I isoform epsilon (EC 2.7.11.1)| (CKI-epsilon) (CKIe) Length = 416 Score = 120 bits (301), Expect = 3e-27 Identities = 64/171 (37%), Positives = 100/171 (58%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +YR+ RK+G G FG +++G + G +EVAIK E +K E Y Sbjct: 8 KYRLGRKIGSGSFGDIYLGANIASG-------EEVAIKLECVKTKHPQLH--IESKFYKM 58 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 + G G+P + + G +GDY VM+M++LGPSL D +N + S + V +A + IS +E Sbjct: 59 MQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 +HSK ++H DVKP+NFL+G + ++++D GLA K++D T QH+ Y Sbjct: 119 IHSKNFIHRDVKPDNFLMGL--GKKGNLVYIIDFGLAKKYRDARTHQHIPY 167
>KC1E_HUMAN (P49674) Casein kinase I isoform epsilon (EC 2.7.11.1)| (CKI-epsilon) (CKIe) Length = 416 Score = 120 bits (301), Expect = 3e-27 Identities = 64/171 (37%), Positives = 100/171 (58%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +YR+ RK+G G FG +++G + G +EVAIK E +K E Y Sbjct: 8 KYRLGRKIGSGSFGDIYLGANIASG-------EEVAIKLECVKTKHPQLH--IESKFYKM 58 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 + G G+P + + G +GDY VM+M++LGPSL D +N + S + V +A + IS +E Sbjct: 59 MQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 +HSK ++H DVKP+NFL+G + ++++D GLA K++D T QH+ Y Sbjct: 119 IHSKNFIHRDVKPDNFLMGL--GKKGNLVYIIDFGLAKKYRDARTHQHIPY 167
>YKL1_CAEEL (P42168) Putative casein kinase I C03C10.1 in chromosome III (EC| 2.7.11.1) Length = 341 Score = 119 bits (299), Expect = 6e-27 Identities = 64/171 (37%), Positives = 100/171 (58%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y++ RK+G G FG ++V +T G +EVAIK E N ++ YE VY Sbjct: 15 KYKLIRKIGSGSFGDIYVSINVTNG-------EEVAIKLESNRARHPQL--LYESKVYRI 65 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 L G G+P + + G + +Y V++MD+LGPSL D +N + + + V +A + I +E Sbjct: 66 LQGGVGIPHIRWYGTEREYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIGRIEY 125 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 +H K ++H D+KP+NFL+G KLFL+D GLA K++D T+ H+ Y Sbjct: 126 VHVKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDSRTRTHIPY 174
>KC1D_ARATH (P42158) Casein kinase I isoform delta-like (EC 2.7.11.1)| (CKI-delta) Length = 450 Score = 119 bits (297), Expect = 9e-27 Identities = 63/171 (36%), Positives = 103/171 (60%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++R+ RK+G G FG +++G + +E+AIK E+ +K YE +Y Sbjct: 8 KFRLGRKIGSGSFGEIYLGTNIHTN-------EELAIKLENVKTKHPQL--LYESKLYRI 58 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 L G GVP V + G +GDY V++MD+LGPSL D +N + +S + V +A + I+ +E Sbjct: 59 LQGGTGVPNVKWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKSVLMLADQMINRVEF 118 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 HSK ++H D+KP+NFL+G + +++++D GLA K++D T QH+ Y Sbjct: 119 FHSKSFLHRDLKPDNFLMGL--GRRANQVYIIDFGLAKKYRDSTTHQHIPY 167
>KC1G1_MOUSE (Q8BTH8) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 459 Score = 117 bits (293), Expect = 3e-26 Identities = 64/173 (36%), Positives = 102/173 (58%), Gaps = 1/173 (0%) Frame = +3 Query: 96 PEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 P +RV +K+G G FG + +G+ L + VAIK E S+ E+ Y Sbjct: 42 PNFRVGKKIGCGNFGELRLGKNLYTN-------EYVAIKLEPIKSRAPQLH--LEYRFYK 92 Query: 276 ALGGT-HGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 LG G+P+V+Y G G Y M++++LGPSL D ++L +T + + V IA + +S + Sbjct: 93 QLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRM 152 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 E +HSK ++ DVKPENFL+G+ G +E + ++D GLA ++ DP T++H+ Y Sbjct: 153 EYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYVDPETKKHIPY 205
>KC1G1_HUMAN (Q9HCP0) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 422 Score = 117 bits (292), Expect = 4e-26 Identities = 64/173 (36%), Positives = 102/173 (58%), Gaps = 1/173 (0%) Frame = +3 Query: 96 PEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 P +RV +K+G G FG + +G+ L + VAIK E S+ E+ Y Sbjct: 42 PNFRVGKKIGCGNFGELRLGKNLYTN-------EYVAIKLEPIKSRAPQLH--LEYRFYK 92 Query: 276 ALGGT-HGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 LG G+P+V+Y G G Y M++++LGPSL D ++L +T + + V IA + +S + Sbjct: 93 QLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRM 152 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 E +HSK ++ DVKPENFL+G+ G +E + ++D GLA ++ DP T++H+ Y Sbjct: 153 EYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPY 205
>KC1G1_RAT (Q62761) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 390 Score = 117 bits (292), Expect = 4e-26 Identities = 64/173 (36%), Positives = 102/173 (58%), Gaps = 1/173 (0%) Frame = +3 Query: 96 PEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 P +RV +K+G G FG + +G+ L + VAIK E S+ E+ Y Sbjct: 42 PNFRVGKKIGCGNFGELRLGKNLYTN-------EYVAIKLEPIKSRAPQLH--LEYRFYK 92 Query: 276 ALGGT-HGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 LG G+P+V+Y G G Y M++++LGPSL D ++L +T + + V IA + +S + Sbjct: 93 QLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRM 152 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 E +HSK ++ DVKPENFL+G+ G +E + ++D GLA ++ DP T++H+ Y Sbjct: 153 EYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPY 205
>KC1_PLAYO (Q7RBX5) Casein kinase I (EC 2.7.11.1)| Length = 323 Score = 115 bits (289), Expect = 8e-26 Identities = 61/180 (33%), Positives = 105/180 (58%) Frame = +3 Query: 78 VQIGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPY 257 ++I + +Y + +KLG G FG ++V + + +E A+K E SK Y Sbjct: 1 MEIRVANKYALGKKLGSGSFGDIYVAKDIVT-------MEEFAVKLESTRSKHPQL--LY 51 Query: 258 EWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAE 437 E +Y LGG GVPKV++ G +GD+ +M++D+LGPSL D + L + S + V A + Sbjct: 52 ESKLYKILGGGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVLMTADQ 111 Query: 438 AISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQ 617 ++ +E +HSK ++H D+KP+NFL+G+ + + ++D GLA K++D + H+ Y + Sbjct: 112 MLNRIEYVHSKNFIHRDIKPDNFLIGR--GKKVTLIHIIDFGLAKKYRDSRSHTHIPYKE 169
>KC1_PLAF7 (Q8IHZ9) Casein kinase I (EC 2.7.11.1)| Length = 323 Score = 115 bits (289), Expect = 8e-26 Identities = 61/180 (33%), Positives = 105/180 (58%) Frame = +3 Query: 78 VQIGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPY 257 ++I + +Y + +KLG G FG ++V + + +E A+K E SK Y Sbjct: 1 MEIRVANKYALGKKLGSGSFGDIYVAKDIVT-------MEEFAVKLESTRSKHPQL--LY 51 Query: 258 EWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAE 437 E +Y LGG GVPKV++ G +GD+ +M++D+LGPSL D + L + S + V A + Sbjct: 52 ESKLYKILGGGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVLMTADQ 111 Query: 438 AISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQ 617 ++ +E +HSK ++H D+KP+NFL+G+ + + ++D GLA K++D + H+ Y + Sbjct: 112 MLNRIEYVHSKNFIHRDIKPDNFLIGR--GKKVTLIHIIDFGLAKKYRDSRSHTHIPYKE 169
>KC1A_DROME (P54367) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (DmCK1) Length = 337 Score = 114 bits (286), Expect = 2e-25 Identities = 64/176 (36%), Positives = 102/176 (57%) Frame = +3 Query: 84 IGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW 263 +GG +YRV RK+G G FG +++G + G +EVAIK E ++ YE Sbjct: 16 VGG--KYRVIRKIGSGSFGDIYLGMSIQSG-------EEVAIKMESAHARHPQL--LYEA 64 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +Y L G G P++ + G++ ++ ++MD+LGPSL D +N + + + V + + I Sbjct: 65 KLYRILSGGVGFPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMI 124 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 LE +H K ++H D+KP+NFL+G KLFL+D GLA K++DP T+ H+ Y Sbjct: 125 GRLEYIHLKCFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKFRDPHTRHHIVY 178
>HHP2_SCHPO (P40236) Casein kinase I homolog hhp2 (EC 2.7.11.1)| Length = 400 Score = 112 bits (280), Expect = 9e-25 Identities = 61/178 (34%), Positives = 101/178 (56%) Frame = +3 Query: 78 VQIGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPY 257 ++IG +YR+ RK+G G FG +++G G ++VA+K E K ++ Y Sbjct: 6 IKIGN--KYRIGRKIGSGSFGQIYLGLNTVNG-------EQVAVKLE--PLKARHHQLEY 54 Query: 258 EWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAE 437 E+ VY+ L G G+P + + G Y M+MD+LGPSL D + G+ + + V +A + Sbjct: 55 EFRVYNILKGNIGIPTIRWFGVTNSYNAMVMDLLGPSLEDLFCYCGRKFTLKTVLLLADQ 114 Query: 438 AISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 IS +E +HSK ++H D+KP+NFL+ + + ++D GLA K++D T H+ Y Sbjct: 115 LISRIEYVHSKSFLHRDIKPDNFLMKK----HSNVVTMIDFGLAKKYRDFKTHVHIPY 168
>DCO_DROME (O76324) Discs overgrown protein kinase (EC 2.7.11.1) (Protein| double-time) Length = 440 Score = 112 bits (280), Expect = 9e-25 Identities = 59/171 (34%), Positives = 101/171 (59%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +YR+ RK+G G FG +++G + G +EVAIK E +K E Y Sbjct: 8 KYRLGRKIGSGSFGDIYLGTTINTG-------EEVAIKLECIRTKHPQLH--IESKFYKT 58 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 + G G+P++ + G +GDY VM+M++LGPSL D +N + S + V +A + IS ++ Sbjct: 59 MQGGIGIPRIIWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRIDY 118 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 +HS+ ++H D+KP+NFL+G + ++++D GLA K++D + +H+ Y Sbjct: 119 IHSRDFIHRDIKPDNFLMGL--GKKGNLVYIIDFGLAKKFRDARSLKHIPY 167
>KC1_PLAF4 (O15726) Casein kinase I (EC 2.7.11.1)| Length = 324 Score = 111 bits (277), Expect = 2e-24 Identities = 61/178 (34%), Positives = 104/178 (58%) Frame = +3 Query: 78 VQIGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPY 257 ++I + +Y + +KLG G FG ++V + + +E A+K E SK Y Sbjct: 1 MEIRVANKYALGKKLGSGSFGDIYVAKDIVT-------MEEFAVKLESTRSKHPQL--LY 51 Query: 258 EWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAE 437 E +Y LGG GVPKV++ G +GD+ +M++D+LGPSL D + L + S + V A + Sbjct: 52 ESKLYKILGGGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVRMTADQ 111 Query: 438 AISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 ++ +E +HSK ++H D+KP+NFL+G+ + + ++D GLA K++D ++ H Y Sbjct: 112 MLNRIEYVHSKNFIHRDIKPDNFLIGR--GKKVTLIHIIDFGLAKKYRD--SRSHTSY 165
>HRR25_YEAST (P29295) Casein kinase I homolog HRR25 (EC 2.7.11.1)| Length = 494 Score = 109 bits (273), Expect = 6e-24 Identities = 58/171 (33%), Positives = 97/171 (56%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++R+ RK+G G FG ++ G L G +EVAIK E S+ YE VY Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISG-------EEVAIKLESIRSRHPQLD--YESRVYRY 58 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 L G G+P + + GR+G+Y M++D+LGPSL D +N + S + V +A + ++ Sbjct: 59 LSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQY 118 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 +H + ++H D+KP+NFL+G + + ++D GL+ K++D T +H+ Y Sbjct: 119 IHGRSFIHRDIKPDNFLMGV--GRRGSTVHVIDFGLSKKYRDFNTHRHIPY 167
>KIN20_CAEEL (Q20471) Casein kinase I isoform delta (EC 2.7.11.1) (Protein| kinase 20) Length = 497 Score = 106 bits (265), Expect = 5e-23 Identities = 57/170 (33%), Positives = 101/170 (59%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 +R+ RK+G G FG +++G+ + +EVA+K E SK E +Y + Sbjct: 191 FRLGRKIGSGSFGDIYLGQNIQTN-------EEVAVKLECVKSKHPQLH--IESRLYRIM 241 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 G G+P++ + G++GDY VM+M++LGPSL D +N + S + V +A + +S +E + Sbjct: 242 LGGIGIPEIRWCGQEGDYNVMVMELLGPSLEDLFNFCQRKFSLKTVLLLADQMLSRVEFI 301 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 H + Y+H D+KP+NFL+G + ++++D GLA +++D + QH+ Y Sbjct: 302 HCRDYIHRDIKPDNFLMGL--GKRGNLVYIIDFGLAKRYRD-SKHQHIAY 348
>KC13_YEAST (P39962) Casein kinase I homolog 3 (EC 2.7.11.1)| Length = 524 Score = 98.6 bits (244), Expect = 1e-20 Identities = 59/199 (29%), Positives = 100/199 (50%), Gaps = 26/199 (13%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQE----------VAIKFEHNTSKGCNYGP 251 Y V K+G+G FG +F G + G++ VAIKFE S Sbjct: 14 YAVGPKIGEGSFGVIFEGENILHSCQAQTGSKRDSSIIMANEPVAIKFEPRHSDAPQLRD 73 Query: 252 PYEWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIA 431 E+ Y L G G+P +Y G++G + ++I+D+LGPSL D + G+ S + +A Sbjct: 74 --EFRAYRILNGCVGIPHAYYFGQEGMHNILIIDLLGPSLEDLFEWCGRKFSVKTTCMVA 131 Query: 432 AEAISILESMHSKGYVHGDVKPENFLLGQPG--TPQEK--------------KLFLVDLG 563 + I + ++H ++ D+KP+NFL+ Q +P+ K +++VD G Sbjct: 132 KQMIDRVRAIHDHDLIYRDIKPDNFLISQYQRISPEGKVIKSCASSSNNDPNLIYMVDFG 191 Query: 564 LATKWKDPATQQHVDYDQR 620 +A +++DP T+QH+ Y +R Sbjct: 192 MAKQYRDPRTKQHIPYRER 210
>KC1A_PIG (O19175) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) (Fragment) Length = 125 Score = 94.0 bits (232), Expect = 3e-19 Identities = 50/128 (39%), Positives = 79/128 (61%) Frame = +3 Query: 195 QEVAIKFEHNTSKGCNYGPPYEWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLW 374 +EVA+K E + K + YE +Y L G G+P + + G++ DY V++MD+LGPSL Sbjct: 2 EEVAVKLE--SQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLE 59 Query: 375 DSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLV 554 D +N + + + V +A + IS +E +H+K ++H D+KP+NFL+G KLFL+ Sbjct: 60 DLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGI--GRHCNKLFLI 117 Query: 555 DLGLATKW 578 D GLA K+ Sbjct: 118 DFGLAKKY 125
>YMX8_CAEEL (P34516) Putative serine/threonine-protein kinase K06H7.1 (EC| 2.7.11.1) Length = 346 Score = 64.3 bits (155), Expect = 3e-10 Identities = 49/171 (28%), Positives = 81/171 (47%), Gaps = 2/171 (1%) Frame = +3 Query: 72 DTVQIGG--SPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNY 245 +T++IG Y+V +KLG+GG G VF ++ + +G Q A+K E + N Sbjct: 8 ETLEIGAVVGKRYKVVQKLGEGGCGSVF---KVEDTSEKG---QHYALKVEFKSQDAGNI 61 Query: 246 GPPYEWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVAC 425 E + S L V K G++ Y M+M +LG SL G ++ Sbjct: 62 -LKMEVQILSQLISKKHVAKCVASGKKERYSYMVMTLLGESLDSLLKKHGPFLNVSTQVR 120 Query: 426 IAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKW 578 I + ++ +H GY+H D+KP N +G G+ E+ ++D GLA ++ Sbjct: 121 IGICILFGIKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQY 171
>KPK2_PLAFK (Q02595) Probable serine/threonine-protein kinase 2 (EC 2.7.11.1)| Length = 510 Score = 57.0 bits (136), Expect = 4e-08 Identities = 48/170 (28%), Positives = 80/170 (47%), Gaps = 1/170 (0%) Frame = +3 Query: 84 IGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW 263 +G Y + +K+GKG F ++G + GN V +K E + SK E Sbjct: 105 LGFKNVYVLNKKIGKGSFSTAYIGTNILYGN-------RVVVK-EVDKSKVKESNVYTEI 156 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 V + + + + ++G Y+++ + G L++ N G +E VA A + + Sbjct: 157 EVLRKVMHKYIIKLISAYEQEGFVYLVLEYLKGGELFEYLNNNGPY--TEQVAKKAMKRV 214 Query: 444 SI-LESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPA 590 I LE++HS G VH D+K EN +L P P K ++D GLA+ P+ Sbjct: 215 LIALEALHSNGVVHRDLKMENLMLENPNDPSSLK--IIDFGLASFLNSPS 262
>CEK1_SCHPO (P38938) Serine/threonine-protein kinase cek1 (EC 2.7.11.1)| Length = 1338 Score = 57.0 bits (136), Expect = 4e-08 Identities = 39/157 (24%), Positives = 71/157 (45%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y++ + + KG FG V++ ++ T G+ +K + +K E + + Sbjct: 588 DYKILKPISKGAFGSVYLAQKRTTGDYFAIKI----LKKSNMIAKNQVINVRAERAILMS 643 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 G + V K++Y + DY ++M+ L S + + + AE + L Sbjct: 644 QGESPFVAKLYYTFQSKDYLYLVMEYLNGGDCGSLLKTMGVLDLDWIRTYIAETVLCLGD 703 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 +H +G +H D+KPEN L+ Q G L L D GL+ Sbjct: 704 LHDRGIIHRDIKPENLLISQNG-----HLKLTDFGLS 735
>TTBK2_MOUSE (Q3UVR3) Tau-tubulin kinase 2| Length = 1243 Score = 56.6 bits (135), Expect = 6e-08 Identities = 47/174 (27%), Positives = 83/174 (47%), Gaps = 4/174 (2%) Frame = +3 Query: 69 PDTVQIG--GSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCN 242 PD + +G ++V RK+G GGFG ++ + + VA+K E +++ Sbjct: 8 PDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLT-------RENVALKVE--SAQQPK 58 Query: 243 YGPPYEWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQ-TMSSEMV 419 E V L G V + GR + ++M + G +L D + T + Sbjct: 59 QVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTT 118 Query: 420 ACIAAEAISILESMHSKGYVHGDVKPENFLLGQ-PGTPQEKKLFLVDLGLATKW 578 + + + +ES+HS G++H D+KP NF +G+ P T +K F++D GLA ++ Sbjct: 119 LRLGKQILESIESIHSVGFLHRDIKPSNFAMGRFPSTC--RKCFMLDFGLARQF 170
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 56.2 bits (134), Expect = 8e-08 Identities = 49/171 (28%), Positives = 83/171 (48%), Gaps = 4/171 (2%) Frame = +3 Query: 69 PDTVQIGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHN---TSKGC 239 PD++ + G +RV R LG GG G V++G +++ G ++VAIK H+ G Sbjct: 4 PDSLVLDG--RFRVLRPLGSGGMGEVYLGEQVSLG-------RKVAIKVLHHDLHAQAGM 54 Query: 240 NYGPPYEWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEM 416 E + SA+ V V + G GD+ ++M+ + G SL+D L M Sbjct: 55 AERFKREARLLSAVEHPAVVRIVDF-GESGDHACLVMEFVEGESLYDV--LTPGPMPPGR 111 Query: 417 VACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 + + L ++H KG +H D+KPEN + + ++ + L+D G+A Sbjct: 112 ALPLLQQLAEGLAAIHDKGIIHRDLKPENVFISKSARGEQAR--LLDFGIA 160
>TTBK2_HUMAN (Q6IQ55) Tau-tubulin kinase 2 (EC 2.7.11.1)| Length = 1244 Score = 55.5 bits (132), Expect = 1e-07 Identities = 46/174 (26%), Positives = 83/174 (47%), Gaps = 4/174 (2%) Frame = +3 Query: 69 PDTVQIG--GSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCN 242 PD + +G ++V RK+G GGFG ++ + + VA+K E +++ Sbjct: 8 PDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLT-------RENVALKVE--SAQQPK 58 Query: 243 YGPPYEWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQ-TMSSEMV 419 E V L G V + GR + ++M + G +L D + T + Sbjct: 59 QVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTT 118 Query: 420 ACIAAEAISILESMHSKGYVHGDVKPENFLLGQ-PGTPQEKKLFLVDLGLATKW 578 + + + +ES+HS G++H D+KP NF +G+ P T +K +++D GLA ++ Sbjct: 119 LRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTC--RKCYMLDFGLARQF 170
>YKL2_CAEEL (P42169) Putative casein kinase I C03C10.2 in chromosome III (EC| 2.7.11.1) Length = 363 Score = 55.1 bits (131), Expect = 2e-07 Identities = 43/161 (26%), Positives = 74/161 (45%), Gaps = 1/161 (0%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + +E +G GG+G +F+ + + R A E ++ E T + E V + Sbjct: 72 WSIEGVIGNGGYGQIFMVMDVKKNDER-AMKIEPKLRAEVITKRMI-----MEQQVLMKM 125 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQ-TMSSEMVACIAAEAISILES 458 G +P ++ G + +IM +L ++ D + +S E V IA + ++ L+ Sbjct: 126 QGKTHIPTMYASGFNDQFNFIIMQLLSMNVGDFRKRSPLGRLSKETVGRIAYQTLNALKD 185 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 +H GYVH DVKP N G L+L+D GL ++K Sbjct: 186 IHDMGYVHRDVKPANICFG-VHAQNRHILYLLDFGLVRRFK 225
>PKNJ_MYCTU (P65732) Probable serine/threonine-protein kinase pknJ (EC| 2.7.11.1) Length = 589 Score = 54.7 bits (130), Expect = 2e-07 Identities = 43/158 (27%), Positives = 70/158 (44%), Gaps = 2/158 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 YR+ER LG GG G V++ R E S+ ++ + A Sbjct: 14 YRIERMLGAGGMGTVYLARN------PDLPRSEALKVLAAELSRDLDFRARFVREADVAA 67 Query: 282 GGTH-GVPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 G H + VH +G+ +G ++ + + G + D+ L TM++ + E L+ Sbjct: 68 GLDHPNIVAVHQRGQFEGRLWIAMQFVDGGNAEDA--LRAATMTTARAVYVIGEVAKALD 125 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 H +G +H D+KP NFLL + E+ L L D G+A Sbjct: 126 YAHQQGVIHRDIKPANFLLSRAAGGDERVL-LSDFGIA 162
>PKNJ_MYCBO (P65733) Probable serine/threonine-protein kinase pknJ (EC| 2.7.11.1) Length = 589 Score = 54.7 bits (130), Expect = 2e-07 Identities = 43/158 (27%), Positives = 70/158 (44%), Gaps = 2/158 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 YR+ER LG GG G V++ R E S+ ++ + A Sbjct: 14 YRIERMLGAGGMGTVYLARN------PDLPRSEALKVLAAELSRDLDFRARFVREADVAA 67 Query: 282 GGTH-GVPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 G H + VH +G+ +G ++ + + G + D+ L TM++ + E L+ Sbjct: 68 GLDHPNIVAVHQRGQFEGRLWIAMQFVDGGNAEDA--LRAATMTTARAVYVIGEVAKALD 125 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 H +G +H D+KP NFLL + E+ L L D G+A Sbjct: 126 YAHQQGVIHRDIKPANFLLSRAAGGDERVL-LSDFGIA 162
>VRK1_HUMAN (Q99986) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) Length = 396 Score = 54.3 bits (129), Expect = 3e-07 Identities = 53/194 (27%), Positives = 80/194 (41%), Gaps = 19/194 (9%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPY-EWHVYS 275 E++V +G+GGFG +++ + G+ A V +K E + + GP + E Y Sbjct: 36 EWKVGLPIGQGGFGCIYLAD-MNSSESVGSDAPCV-VKVEPSDN-----GPLFTELKFYQ 88 Query: 276 ALGGTH--------------GVPKVHYKGRQG----DYYVMIMDMLGPSLWDSWNLAGQT 401 GVPK G Y MIMD G L + + Sbjct: 89 RAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR 148 Query: 402 MSSEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 S + V ++ + ILE +H YVHGD+K N LL Q ++LVD GLA ++ Sbjct: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQ---VYLVDYGLAYRYC 205 Query: 582 DPATQQHVDYDQRP 623 H +Y + P Sbjct: 206 PEGV--HKEYKEDP 217
>VRK1_MOUSE (Q80X41) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK) Length = 440 Score = 54.3 bits (129), Expect = 3e-07 Identities = 51/192 (26%), Positives = 79/192 (41%), Gaps = 17/192 (8%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFV----GRRLTGGNG--------RGAGAQEVAIKFEHNTSKGCN 242 E+++ +G+GGFG +++ + G + G +KF +K Sbjct: 36 EWKLGLPIGQGGFGCIYLADTNSSKPVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 Query: 243 YGPPYEWHVYSALGGTHGVPK-----VHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMS 407 H L GVPK +H K + Y MIMD G L + + S Sbjct: 96 IQKWIRTHKLKYL----GVPKYWGSGLHDKNGK-SYRFMIMDRFGSDLQKIYEANAKRFS 150 Query: 408 SEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDP 587 + V ++ + ILE +H YVHGD+K N LL Q ++LVD GLA ++ Sbjct: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLSHKNPDQ---VYLVDYGLAYRYCPD 207 Query: 588 ATQQHVDYDQRP 623 H +Y + P Sbjct: 208 GV--HKEYKEDP 217
>VPK1_VACCV (P16913) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 53.9 bits (128), Expect = 4e-07 Identities = 31/104 (29%), Positives = 52/104 (50%) Frame = +3 Query: 312 YKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDV 491 YK +Y ++++ LG L + V I E ++ ++ MH +GY HGD+ Sbjct: 89 YKSINVEYRFLVINRLGADLDAVIRANNNRLPKRSVMLIGIEILNTIQFMHEQGYSHGDI 148 Query: 492 KPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQRP 623 K N +L Q + KL+LVD GL +K+ + +HV + + P Sbjct: 149 KASNIVLDQ---IDKNKLYLVDYGLVSKFM--SNGEHVPFIRNP 187
>VPK1_VACCA (O57252) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 53.9 bits (128), Expect = 4e-07 Identities = 31/104 (29%), Positives = 52/104 (50%) Frame = +3 Query: 312 YKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDV 491 YK +Y ++++ LG L + V I E ++ ++ MH +GY HGD+ Sbjct: 89 YKSINVEYRFLVINRLGADLDAVIRANNNRLPKRSVMLIGIEILNTIQFMHEQGYSHGDI 148 Query: 492 KPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQRP 623 K N +L Q + KL+LVD GL +K+ + +HV + + P Sbjct: 149 KASNIVLDQ---IDKNKLYLVDYGLVSKFM--SNGEHVPFIRNP 187
>MRCKG_MOUSE (Q80UW5) Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1)| (CDC42-binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma Length = 1551 Score = 53.5 bits (127), Expect = 5e-07 Identities = 42/145 (28%), Positives = 64/145 (44%), Gaps = 3/145 (2%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTS--KGCNYGPPYEWHVY 272 ++ + + +G+G FG V V R+ RG+G Q A+K H K E Sbjct: 70 DFEILKVIGRGAFGEVAVVRQ------RGSG-QIFAMKMLHKWEMLKRAETACFREERDV 122 Query: 273 SALGGTHGVPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISI 449 G + V +HY + +Y ++MD G L + + E+ AE + Sbjct: 123 LVKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLA 182 Query: 450 LESMHSKGYVHGDVKPENFLLGQPG 524 + S+H GYVH DVKP+N LL G Sbjct: 183 IHSLHQLGYVHRDVKPDNILLDMNG 207
>VPK1_VACCC (P20505) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 53.5 bits (127), Expect = 5e-07 Identities = 31/104 (29%), Positives = 52/104 (50%) Frame = +3 Query: 312 YKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDV 491 YK +Y ++++ LG L + V I E ++ ++ MH +GY HGD+ Sbjct: 89 YKSINVEYRFLVINRLGVDLDAVIRANNNRLPKRSVMLIGIEILNTIQFMHEQGYSHGDI 148 Query: 492 KPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQRP 623 K N +L Q + KL+LVD GL +K+ + +HV + + P Sbjct: 149 KASNIVLDQ---IDKNKLYLVDYGLVSKFM--SNGEHVPFIRNP 187
>TTBK1_HUMAN (Q5TCY1) Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau| kinase) Length = 1321 Score = 52.8 bits (125), Expect = 8e-07 Identities = 42/161 (26%), Positives = 78/161 (48%), Gaps = 2/161 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 ++V +K+G GGFG ++ L + VA+K E +++ E V L Sbjct: 34 WKVLKKIGGGGFGEIYEAMDLLT-------RENVALKVE--SAQQPKQVLKMEVAVLKKL 84 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQ-TMSSEMVACIAAEAISILES 458 G V + GR + ++M + G +L D + T + + + + +E+ Sbjct: 85 QGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEA 144 Query: 459 MHSKGYVHGDVKPENFLLGQ-PGTPQEKKLFLVDLGLATKW 578 +HS G++H D+KP NF +G+ P T +K +++D GLA ++ Sbjct: 145 IHSVGFLHRDIKPSNFAMGRLPST--YRKCYMLDFGLARQY 183
>VPK1_VARV (P33800) Serine/threonine-protein kinase 1 (EC 2.7.11.1)| Length = 300 Score = 52.0 bits (123), Expect = 1e-06 Identities = 29/104 (27%), Positives = 52/104 (50%) Frame = +3 Query: 312 YKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDV 491 YK +Y ++++ LG L + V + E ++ ++ MH +GY HG++ Sbjct: 89 YKSINTEYRFLVINRLGVDLDAVIRANNNRLPKRSVMLVGIEILNTIQFMHEQGYSHGNI 148 Query: 492 KPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQRP 623 K N +L Q + KL+LVD GL +K+ + +HV + + P Sbjct: 149 KASNIVLDQ---MDKNKLYLVDYGLVSKFM--SNGEHVPFIRNP 187
>VRK1_BRARE (Q7ZUS1) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) Length = 425 Score = 52.0 bits (123), Expect = 1e-06 Identities = 35/99 (35%), Positives = 48/99 (48%), Gaps = 4/99 (4%) Frame = +3 Query: 294 GVPKVHYKG---RQGDYY-VMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 GVPK G + G Y M+MD G L + G+ S ++V + + ILE + Sbjct: 110 GVPKYWGSGFHEKNGKRYRFMVMDRFGTDLQKLFEGNGKKFSRKLVLQLGLRLLDILEYI 169 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKW 578 H YVH D+K N LL Q +FLVD GLA ++ Sbjct: 170 HDHEYVHADIKASNLLLSYTNPNQ---VFLVDYGLAYRY 205
>PIM2_HUMAN (Q9P1W9) Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1)| (Pim-2h) Length = 311 Score = 50.8 bits (120), Expect = 3e-06 Identities = 45/150 (30%), Positives = 66/150 (44%), Gaps = 12/150 (8%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF----------EHNTSKGCNYG 248 EYR+ LGKGGFG VF G RLT +VAIK + S C Sbjct: 31 EYRLGPLLGKGGFGTVFAGHRLT-------DRLQVAIKVIPRNRVLGWSPLSDSVTCPLE 83 Query: 249 PPYEWHVYSALGGTHGVPKV--HYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVA 422 W V A GG GV ++ ++ ++G V+ + L+D G + Sbjct: 84 VALLWKV-GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKG-PLGEGPSR 141 Query: 423 CIAAEAISILESMHSKGYVHGDVKPENFLL 512 C + ++ ++ HS+G VH D+K EN L+ Sbjct: 142 CFFGQVVAAIQHCHSRGVVHRDIKDENILI 171
>VRK2_HUMAN (Q86Y07) Serine/threonine-protein kinase VRK2 (EC 2.7.11.1)| (Vaccinia-related kinase 2) Length = 508 Score = 50.8 bits (120), Expect = 3e-06 Identities = 49/184 (26%), Positives = 75/184 (40%), Gaps = 14/184 (7%) Frame = +3 Query: 114 RKLGKGGFGHVFVG----------RRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW 263 +K+G GGFG +++ R + + G +KF +K E Sbjct: 33 KKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER 92 Query: 264 HVYSALGGT--HGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQ--TMSSEMVACIA 431 LG +G +KGR Y M+M+ LG L ++GQ T V + Sbjct: 93 KQLDYLGIPLFYGSGLTEFKGRS--YRFMVMERLGIDLQ---KISGQNGTFKKSTVLQLG 147 Query: 432 AEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 + +LE +H YVHGD+K N LLG Q ++L D GL+ ++ H Y Sbjct: 148 IRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQ---VYLADYGLSYRY--CPNGNHKQY 202 Query: 612 DQRP 623 + P Sbjct: 203 QENP 206
>V212_FOWPV (Q9J523) Probable serine/threonine-protein kinase FPV212 (EC| 2.7.11.1) Length = 303 Score = 50.4 bits (119), Expect = 4e-06 Identities = 34/114 (29%), Positives = 59/114 (51%), Gaps = 4/114 (3%) Frame = +3 Query: 294 GVPKVHYKG----RQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 G+P H G + +Y I+ LG L + + + + ++ +A + + IL+ + Sbjct: 93 GIPSFHGFGITIYKNVEYRFAIIQRLGRDLENILS-EKEKFNITVIKKLAIKILDILKFI 151 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQRP 623 HSK + HGD+K N L G+ + K++LVD GLATK+ + +H +Y P Sbjct: 152 HSKEFSHGDIKAGNILFGK----DDDKVYLVDYGLATKYS--SNGKHKEYTINP 199
>MRCKG_HUMAN (Q6DT37) Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1)| (CDC42-binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma Length = 1551 Score = 50.1 bits (118), Expect = 5e-06 Identities = 40/145 (27%), Positives = 61/145 (42%), Gaps = 3/145 (2%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTS--KGCNYGPPYEWHVY 272 ++ + + +G+G FG V V R+ G Q A+K H K E Sbjct: 70 DFEILKVIGRGAFGEVTVVRQRDTG-------QIFAMKMLHKWEMLKRAETACFREERDV 122 Query: 273 SALGGTHGVPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISI 449 G + V +HY + +Y ++MD G L + + E+ AE + Sbjct: 123 LVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLA 182 Query: 450 LESMHSKGYVHGDVKPENFLLGQPG 524 + S+H GYVH DVKP+N LL G Sbjct: 183 IHSLHQLGYVHRDVKPDNVLLDVNG 207
>NHK1_DROME (Q7KRY6) Nucleosomal histone kinase 1 (EC 2.7.11.1) (Protein| baellchen) Length = 599 Score = 50.1 bits (118), Expect = 5e-06 Identities = 42/168 (25%), Positives = 72/168 (42%), Gaps = 10/168 (5%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGN--------GRGAGAQEVAIKFEHNTSKGCNYGPP 254 ++R+ +G GGFG ++ ++ N G G V + F +K + Sbjct: 46 QWRIGPSIGVGGFGEIYAACKVGEKNYDAVVKCEPHGNGPLFVEMHFYLRNAKLEDIKQF 105 Query: 255 YEWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAA 434 + H +LG + + + + ++M G L G+ + V +A Sbjct: 106 MQKHGLKSLGMPYILANGSVEVNGEKHRFIVMPRYGSDLTKFLEQNGKRLPEGTVYRLAI 165 Query: 435 EAISILESMHSKGYVHGDVKPENFLLG--QPGTPQEKKLFLVDLGLAT 572 + + + + MHS GYVH D+K N LLG + G Q +LVD GLA+ Sbjct: 166 QMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQ---AYLVDFGLAS 210
>DMPK_HUMAN (Q09013) Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy| protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK) Length = 639 Score = 49.7 bits (117), Expect = 7e-06 Identities = 29/105 (27%), Positives = 52/105 (49%), Gaps = 1/105 (0%) Frame = +3 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDM-LGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 G + ++H+ + +Y ++M+ +G L + G+ + +EM AE + ++S Sbjct: 136 GDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDS 195 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPAT 593 +H GYVH D+KP+N LL + G + L D G K + T Sbjct: 196 VHRLGYVHRDIKPDNILLDRCG-----HIRLADFGSCLKLRADGT 235
>ROCK1_RABIT (O77819) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (cAMP-dependent protein kinase ROCK-I) (CePKA) (Corneal epithelial Rho-associated-Ser/Thr kinase 1) (HEB Length = 1354 Score = 49.3 bits (116), Expect = 9e-06 Identities = 44/160 (27%), Positives = 72/160 (45%), Gaps = 1/160 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y V + +G+G FG V + R + R A ++ KFE K + +E A Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKST---RKVYAMKLLSKFE--MIKRSDSAFFWEERDIMA 129 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNL-AGQTMSSEMVACIAAEAISILE 455 + V ++ Y + Y M+M+ + D NL + + + AE + L+ Sbjct: 130 FANSPWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWARFYTAEVVLALD 187 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 ++HS G++H DVKP+N LL + G L L D G K Sbjct: 188 AIHSMGFIHRDVKPDNMLLDKSG-----HLKLADFGTCMK 222
>ROCK1_MOUSE (P70335) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) Length = 1354 Score = 49.3 bits (116), Expect = 9e-06 Identities = 44/160 (27%), Positives = 72/160 (45%), Gaps = 1/160 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y V + +G+G FG V + R + R A ++ KFE K + +E A Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKST---RKVYAMKLLSKFE--MIKRSDSAFFWEERDIMA 129 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNL-AGQTMSSEMVACIAAEAISILE 455 + V ++ Y + Y M+M+ + D NL + + + AE + L+ Sbjct: 130 FANSPWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWARFYTAEVVLALD 187 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 ++HS G++H DVKP+N LL + G L L D G K Sbjct: 188 AIHSMGFIHRDVKPDNMLLDKSG-----HLKLADFGTCMK 222
>ROCK1_HUMAN (Q13464) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen) Length = 1354 Score = 49.3 bits (116), Expect = 9e-06 Identities = 44/160 (27%), Positives = 72/160 (45%), Gaps = 1/160 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y V + +G+G FG V + R + R A ++ KFE K + +E A Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKST---RKVYAMKLLSKFE--MIKRSDSAFFWEERDIMA 129 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNL-AGQTMSSEMVACIAAEAISILE 455 + V ++ Y + Y M+M+ + D NL + + + AE + L+ Sbjct: 130 FANSPWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWARFYTAEVVLALD 187 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 ++HS G++H DVKP+N LL + G L L D G K Sbjct: 188 AIHSMGFIHRDVKPDNMLLDKSG-----HLKLADFGTCMK 222
>CDC7_HUMAN (O00311) Cell division cycle 7-related protein kinase (EC 2.7.11.1)| (CDC7-related kinase) (HsCdc7) (huCdc7) Length = 574 Score = 49.3 bits (116), Expect = 9e-06 Identities = 47/157 (29%), Positives = 69/157 (43%), Gaps = 1/157 (0%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 +++E K+G+G F V+ L + +++A+K TS E + Sbjct: 58 FKIEDKIGEGTFSSVY----LATAQLQVGPEEKIALKHLIPTSHPIRIAA--ELQCLTVA 111 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLG-PSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 GG V V Y R+ D+ V+ M L S D N ++S + V L+ Sbjct: 112 GGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILN----SLSFQEVREYMLNLFKALKR 167 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 +H G VH DVKP NFL + + KK LVD GLA Sbjct: 168 IHQFGIVHRDVKPSNFLYNR----RLKKYALVDFGLA 200
>ROCK1_RAT (Q63644) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (p150 RhoA-binding kinase ROK beta) (Liver regeneration-related protein LRRG199) Length = 1369 Score = 49.3 bits (116), Expect = 9e-06 Identities = 44/160 (27%), Positives = 72/160 (45%), Gaps = 1/160 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y V + +G+G FG V + R + R A ++ KFE K + +E A Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKST---RKVYAMKLLSKFE--MIKRSDSAFFWEERDIMA 129 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNL-AGQTMSSEMVACIAAEAISILE 455 + V ++ Y + Y M+M+ + D NL + + + AE + L+ Sbjct: 130 FANSPWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWARFYTAEVVLALD 187 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 ++HS G++H DVKP+N LL + G L L D G K Sbjct: 188 AIHSMGFIHRDVKPDNMLLDKSG-----HLKLADFGTCMK 222
>DMPK_MOUSE (P54265) Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy| protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK) Length = 631 Score = 48.9 bits (115), Expect = 1e-05 Identities = 24/82 (29%), Positives = 45/82 (54%), Gaps = 1/82 (1%) Frame = +3 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDM-LGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 G + ++H+ + +Y ++M+ +G L + G+ + +EM AE + ++S Sbjct: 126 GDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDS 185 Query: 459 MHSKGYVHGDVKPENFLLGQPG 524 +H GYVH D+KP+N LL + G Sbjct: 186 VHRLGYVHRDIKPDNILLDRCG 207
>KS6B1_RAT (P67999) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (p70-S6K) Length = 525 Score = 48.9 bits (115), Expect = 1e-05 Identities = 46/168 (27%), Positives = 71/168 (42%), Gaps = 1/168 (0%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + + R LGKGG+G VF R++TG N A +V K + E ++ + Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISI-LES 458 V ++ G Y+++ + G L+ G M E AC IS+ L Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM--EDTACFYLAEISMALGH 208 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQH 602 +H KG ++ D+KPEN +L G + L D GL + T H Sbjct: 209 LHQKGIIYRDLKPENIMLNHQG-----HVKLTDFGLCKESIHDGTVTH 251
>KS6B1_RABIT (P67998) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (p70-S6K) Length = 525 Score = 48.9 bits (115), Expect = 1e-05 Identities = 46/168 (27%), Positives = 71/168 (42%), Gaps = 1/168 (0%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + + R LGKGG+G VF R++TG N A +V K + E ++ + Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISI-LES 458 V ++ G Y+++ + G L+ G M E AC IS+ L Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM--EDTACFYLAEISMALGH 208 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQH 602 +H KG ++ D+KPEN +L G + L D GL + T H Sbjct: 209 LHQKGIIYRDLKPENIMLNHQG-----HVKLTDFGLCKESIHDGTVTH 251
>KS6B1_MOUSE (Q8BSK8) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (p70-S6K) Length = 525 Score = 48.9 bits (115), Expect = 1e-05 Identities = 46/168 (27%), Positives = 71/168 (42%), Gaps = 1/168 (0%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + + R LGKGG+G VF R++TG N A +V K + E ++ + Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISI-LES 458 V ++ G Y+++ + G L+ G M E AC IS+ L Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM--EDTACFYLAEISMALGH 208 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQH 602 +H KG ++ D+KPEN +L G + L D GL + T H Sbjct: 209 LHQKGIIYRDLKPENIMLNHQG-----HVKLTDFGLCKESIHDGTVTH 251
>KS6B1_HUMAN (P23443) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (p70-alpha) Length = 525 Score = 48.9 bits (115), Expect = 1e-05 Identities = 46/168 (27%), Positives = 71/168 (42%), Gaps = 1/168 (0%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + + R LGKGG+G VF R++TG N A +V K + E ++ + Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISI-LES 458 V ++ G Y+++ + G L+ G M E AC IS+ L Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM--EDTACFYLAEISMALGH 208 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQH 602 +H KG ++ D+KPEN +L G + L D GL + T H Sbjct: 209 LHQKGIIYRDLKPENIMLNHQG-----HVKLTDFGLCKESIHDGTVTH 251
>SPKD_SYNY3 (P54735) Serine/threonine-protein kinase D (EC 2.7.11.1)| Length = 505 Score = 48.1 bits (113), Expect = 2e-05 Identities = 42/153 (27%), Positives = 67/153 (43%), Gaps = 16/153 (10%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGR-------------RLTGGNGRGAGAQEVAIK-FEHNTSKGC 239 Y + + LG GGFG F+ + RL N + E+ K FE S Sbjct: 9 YEIVKSLGSGGFGDTFLAKDTQIPSQKLVVIKRLKPANANSNTSTELIQKLFEKEAS--- 65 Query: 240 NYGPPYEWHVYSALGGTHG-VPKVH-YKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSE 413 V LG + +PK++ Y ++Y++ + G SL + +SSE Sbjct: 66 ---------VLEDLGEHNSQIPKLYSYFSNDNEFYLVQEYIQGVSLNEI-----APISSE 111 Query: 414 MVACIAAEAISILESMHSKGYVHGDVKPENFLL 512 I + ++ L+ +HSKG +H D+KPEN +L Sbjct: 112 QAKTILSSLLTTLKYIHSKGIIHRDIKPENIIL 144
>PIM3_HUMAN (Q86V86) Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1)| Length = 326 Score = 47.8 bits (112), Expect = 3e-05 Identities = 49/181 (27%), Positives = 77/181 (42%), Gaps = 10/181 (5%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF---EHNTSKGCNYGPPYEWHV- 269 Y+V LG GGFG V+ G R+ G VA+K E T G G V Sbjct: 40 YQVGAVLGSGGFGTVYAGSRIADG-------LPVAVKHVVKERVTEWGSLGGATVPLEVV 92 Query: 270 ----YSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPS--LWDSWNLAGQTMSSEMVACIA 431 A GG GV ++ + D ++++++ P+ L+D G + + Sbjct: 93 LLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERG-ALDEPLARRFF 151 Query: 432 AEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 A+ ++ + HS G VH D+K EN L+ + +L L+D G KD + D+ Sbjct: 152 AQVLAAVRHCHSCGVVHRDIKDENLLVDL----RSGELKLIDFGSGALLKDTV---YTDF 204 Query: 612 D 614 D Sbjct: 205 D 205
>KKR1_YEAST (P36003) Probable serine/threonine-protein kinase YKL171W (EC| 2.7.11.1) Length = 928 Score = 47.8 bits (112), Expect = 3e-05 Identities = 22/64 (34%), Positives = 39/64 (60%) Frame = +3 Query: 426 IAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHV 605 ++ + +S L+ MHSK VHGD+K EN LL + G + K+FL D G++ + + ++ Sbjct: 560 LSLQLLSALKYMHSKTIVHGDIKLENCLLQKEGKKSDWKVFLCDFGMSCHFDEKHVYRND 619 Query: 606 DYDQ 617 +D+ Sbjct: 620 TFDE 623
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 47.0 bits (110), Expect = 5e-05 Identities = 41/161 (25%), Positives = 68/161 (42%), Gaps = 1/161 (0%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGP-PYEWHVYSA 278 Y + +G GGF V + + G + VAIK + G + E + Sbjct: 11 YELYETIGTGGFAKVKLACHVLTG-------EMVAIKIMDKNALGSDLPRVKTEIDALKS 63 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 L H H + ++++ G L+D + ++ +S E + + +S + Sbjct: 64 LRHQHICQLYHVLETKNKIFMVLEYCPGGELFD-YIISQDRLSEEETRVVFRQILSAVAY 122 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 +HS+GY H D+KPEN L + KL L+D GL K K Sbjct: 123 VHSQGYAHRDLKPENLLF-----DENHKLKLIDFGLCAKPK 158
>KK31_SCHPO (Q9HFF4) Probable serine/threonine-protein kinase C110.01 (EC| 2.7.11.1) Length = 1023 Score = 47.0 bits (110), Expect = 5e-05 Identities = 43/161 (26%), Positives = 72/161 (44%), Gaps = 4/161 (2%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGR-GAGAQEVAIKFEHNTSKGCNYGPPY-EWHVYS 275 Y + R +G G FG V +G L N +V IK +T + C E + Sbjct: 492 YILGRTIGTGEFGKVKLGWPLPKANSTIHRSTPQVVIKIVLSTKQNCQTSRLMREVAILK 551 Query: 276 ALGGTHG--VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISI 449 LG H V + + + + +++ + G L+D + LA + + + + A+ IS Sbjct: 552 GLGNNHPHIVKYLDFVKTKHHFGIVLDYVNGGELFD-YILARRRLEDSVACRLFAQLISG 610 Query: 450 LESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 + +HS+G VH D+K EN LL + + + D G AT Sbjct: 611 VAYLHSRGVVHRDLKLENILL-----DTNRNIVIADFGFAT 646
>CTRO_HUMAN (O14578) Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK)| (Rho-interacting, serine/threonine-protein kinase 21) Length = 2027 Score = 46.6 bits (109), Expect = 6e-05 Identities = 28/94 (29%), Positives = 46/94 (48%), Gaps = 1/94 (1%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKG 473 +P++ Y + ++ ++M+ G L N + ++ AE I + S+H G Sbjct: 157 IPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMG 216 Query: 474 YVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 YVH D+KPEN L+ + G + LVD G A K Sbjct: 217 YVHRDIKPENILVDRTG-----HIKLVDFGSAAK 245
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 46.6 bits (109), Expect = 6e-05 Identities = 42/159 (26%), Positives = 76/159 (47%), Gaps = 2/159 (1%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + LG+G FG VF+ ++++G + R A +V K E + Sbjct: 67 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVR--TKMERDILVE 124 Query: 279 LGGTHGVPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTM-SSEMVACIAAEAISIL 452 + + K+HY + +G Y+++ + G L+ L+ + M + E V AE L Sbjct: 125 VNHPF-IVKLHYAFQTEGKLYLILDFLRGGDLFT--RLSKEVMFTEEDVKFYLAELALAL 181 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 + +HS G ++ D+KPEN LL + G + L D GL+ Sbjct: 182 DHLHSLGIIYRDLKPENILLDEEG-----HIKLTDFGLS 215 Score = 32.0 bits (71), Expect = 1.5 Identities = 23/79 (29%), Positives = 37/79 (46%), Gaps = 1/79 (1%) Frame = +3 Query: 336 YVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFL-L 512 YV+ M G L D L + S + + +E +H++G VH D+KP N L + Sbjct: 490 YVVTELMKGGELLDKI-LRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYV 548 Query: 513 GQPGTPQEKKLFLVDLGLA 569 + G P+ + + D G A Sbjct: 549 DESGNPE--SIRICDFGFA 565
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 46.6 bits (109), Expect = 6e-05 Identities = 42/159 (26%), Positives = 76/159 (47%), Gaps = 2/159 (1%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + LG+G FG VF+ ++++G + R A +V K E + Sbjct: 67 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVR--TKMERDILVE 124 Query: 279 LGGTHGVPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTM-SSEMVACIAAEAISIL 452 + + K+HY + +G Y+++ + G L+ L+ + M + E V AE L Sbjct: 125 VNHPF-IVKLHYAFQTEGKLYLILDFLRGGDLFT--RLSKEVMFTEEDVKFYLAELALAL 181 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 + +HS G ++ D+KPEN LL + G + L D GL+ Sbjct: 182 DHLHSLGIIYRDLKPENILLDEEG-----HIKLTDFGLS 215 Score = 32.0 bits (71), Expect = 1.5 Identities = 23/79 (29%), Positives = 37/79 (46%), Gaps = 1/79 (1%) Frame = +3 Query: 336 YVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFL-L 512 YV+ M G L D L + S + + +E +H++G VH D+KP N L + Sbjct: 490 YVVTELMKGGELLDKI-LRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYV 548 Query: 513 GQPGTPQEKKLFLVDLGLA 569 + G P+ + + D G A Sbjct: 549 DESGNPE--SIRICDFGFA 565
>CTRO_MOUSE (P49025) Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK)| (Rho-interacting, serine/threonine-protein kinase 21) Length = 2055 Score = 46.6 bits (109), Expect = 6e-05 Identities = 28/94 (29%), Positives = 45/94 (47%), Gaps = 1/94 (1%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKG 473 +P++ Y + + ++M+ G N + M+ AE I + S+H G Sbjct: 157 IPQLQYAFQDKNNLYLVMEYQPGGDFLSLLNRYEDQLDESMIQFYLAELILAVHSVHQMG 216 Query: 474 YVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 YVH D+KPEN L+ + G ++ LVD G A K Sbjct: 217 YVHRDIKPENILIDRTG-----EIKLVDFGSAAK 245
>E2AK3_CAEEL (Q19192) Eukaryotic translation initiation factor 2-alpha kinase| precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (PERK) (PEK) (CePEK) Length = 1077 Score = 46.2 bits (108), Expect = 8e-05 Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 5/96 (5%) Frame = +3 Query: 303 KVHYKGRQGD--YYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIA---AEAISILESMHS 467 +V + GD Y ++M + + W +TM S + + + S LE +H+ Sbjct: 867 EVRERNDTGDCAYLYIVMQLCAEKTLEDWIRRSKTMESRPLFTMKNWIKQLASGLEYLHN 926 Query: 468 KGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 KG++H D+KP N T + L + DLGLATK Sbjct: 927 KGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLATK 962
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 46.2 bits (108), Expect = 8e-05 Identities = 41/161 (25%), Positives = 66/161 (40%), Gaps = 1/161 (0%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGP-PYEWHVYSA 278 Y + +G GGF V + + G + VAIK + G + E Sbjct: 11 YELHETIGTGGFAKVKLACHILTG-------EMVAIKIMDKNTLGSDLPRIKTEIEALKN 63 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 L H H ++++ G L+D + ++ +S E + + +S + Sbjct: 64 LRHQHICQLYHVLETANKIFMVLEYCPGGELFD-YIISQDRLSEEETRVVFRQIVSAVAY 122 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 +HS+GY H D+KPEN L + KL L+D GL K K Sbjct: 123 VHSQGYAHRDLKPENLLF-----DEYHKLKLIDFGLCAKPK 158
>MRCKB_RAT (Q7TT49) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1713 Score = 46.2 bits (108), Expect = 8e-05 Identities = 41/168 (24%), Positives = 68/168 (40%), Gaps = 1/168 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + +G+G FG V V + N A ++ K+E K E Sbjct: 75 DFEIIKVIGRGAFGEVAVVKMK---NTERIYAMKILNKWE--MLKRAETACFREERDVLV 129 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDM-LGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 G + +HY + +Y ++MD +G L + + +M E + ++ Sbjct: 130 NGDCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAID 189 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 S+H YVH D+KP+N LL G + L D G K D T Q Sbjct: 190 SIHQLHYVHRDIKPDNVLLDVNG-----HIRLADFGSCLKMNDDGTVQ 232
>MRCKB_MOUSE (Q7TT50) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1713 Score = 46.2 bits (108), Expect = 8e-05 Identities = 41/168 (24%), Positives = 68/168 (40%), Gaps = 1/168 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + +G+G FG V V + N A ++ K+E K E Sbjct: 75 DFEIIKVIGRGAFGEVAVVKMR---NTERIYAMKILNKWE--MLKRAETACFREERDVLV 129 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDM-LGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 G + +HY + +Y ++MD +G L + + +M E + ++ Sbjct: 130 NGDCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAID 189 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 S+H YVH D+KP+N LL G + L D G K D T Q Sbjct: 190 SIHQLHYVHRDIKPDNVLLDVNG-----HIRLADFGSCLKMNDDGTVQ 232
>YOO3_CAEEL (P34635) Putative serine/threonine-protein kinase ZK507.3 (EC| 2.7.11.1) Length = 374 Score = 46.2 bits (108), Expect = 8e-05 Identities = 39/172 (22%), Positives = 78/172 (45%), Gaps = 8/172 (4%) Frame = +3 Query: 96 PEY--RVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHV 269 P+Y +V +LGKGG+G V ++ G +E A+K E + + E +V Sbjct: 21 PDYNWKVIVELGKGGYGTVNKVIKVNE-EGFAIDDKEYAMKTEQKFASKHSSRLKIERNV 79 Query: 270 YSALGGTHGVPKVHYK-----GRQGDYYVMIMDMLGPSLWD-SWNLAGQTMSSEMVACIA 431 ++ K H+ G+ + ++M ++GPSL + + + Sbjct: 80 MASYSKCDAQCKEHFPELIDFGQSPVWKWIVMTIVGPSLEELKMKYKPSDIPPSTILQCG 139 Query: 432 AEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDP 587 + + + H G++H D+KP N+ +G + + ++++D GLA K++ P Sbjct: 140 LQTMKAIHDFHQIGFLHRDIKPANYCIGYGS--KSETIYVLDFGLARKYRLP 189
>PIM3_RAT (O70444) Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1)| (Protein kinase Kid-1) (Kinase induced by depolarization) Length = 326 Score = 46.2 bits (108), Expect = 8e-05 Identities = 48/181 (26%), Positives = 77/181 (42%), Gaps = 10/181 (5%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF---EHNTSKGCNYGPPYEWHV- 269 Y+V LG GGFG V+ G R+ G VA+K E T G G V Sbjct: 40 YQVGAVLGSGGFGTVYAGSRIADG-------LPVAVKHVVKERVTEWGSLGGMAVPLEVV 92 Query: 270 ----YSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPS--LWDSWNLAGQTMSSEMVACIA 431 A GG GV ++ + D ++++++ P+ L+D G + + Sbjct: 93 LLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERG-ALDEPLARRFF 151 Query: 432 AEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 A+ ++ + H+ G VH D+K EN L+ + +L L+D G KD + D+ Sbjct: 152 AQVLAAVRHCHNCGVVHRDIKDENLLVDL----RSGELKLIDFGSGAVLKDTV---YTDF 204 Query: 612 D 614 D Sbjct: 205 D 205
>PIM3_MOUSE (P58750) Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1)| Length = 326 Score = 46.2 bits (108), Expect = 8e-05 Identities = 48/181 (26%), Positives = 77/181 (42%), Gaps = 10/181 (5%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF---EHNTSKGCNYGPPYEWHV- 269 Y+V LG GGFG V+ G R+ G VA+K E T G G V Sbjct: 40 YQVGAVLGSGGFGTVYAGSRIADG-------LPVAVKHVVKERVTEWGSLGGVAVPLEVV 92 Query: 270 ----YSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPS--LWDSWNLAGQTMSSEMVACIA 431 A GG GV ++ + D ++++++ P+ L+D G + + Sbjct: 93 LLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERG-ALDEPLARRFF 151 Query: 432 AEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDY 611 A+ ++ + H+ G VH D+K EN L+ + +L L+D G KD + D+ Sbjct: 152 AQVLAAVRHCHNCGVVHRDIKDENLLVDL----RSGELKLIDFGSGAVLKDTV---YTDF 204 Query: 612 D 614 D Sbjct: 205 D 205
>CDC7_MOUSE (Q9Z0H0) Cell division cycle 7-related protein kinase (EC 2.7.11.1)| (CDC7-related kinase) (muCdc7) Length = 564 Score = 46.2 bits (108), Expect = 8e-05 Identities = 47/162 (29%), Positives = 73/162 (45%), Gaps = 2/162 (1%) Frame = +3 Query: 105 RVERKLGKGGFGHVFVGR-RLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 +++ K+G+G F V++ +L G+ +++A+K TS E + Sbjct: 53 KIKDKIGEGTFSSVYLATAQLQEGH-----EEKIALKHLIPTSHPMRIAA--ELQCLTVA 105 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLG-PSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 GG V + Y R+ D+ V+ M L S D N ++S + V L+ Sbjct: 106 GGQDNVMGLKYCFRKNDHVVIAMPYLEHESFLDILN----SLSFQEVREYMYNLFVALKR 161 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKD 584 +H G VH DVKP NFL + + KK LVD GLA +D Sbjct: 162 IHQFGIVHRDVKPSNFLYNR----RLKKYALVDFGLAQGTRD 199
>GRK5_BOVIN (P43249) G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK5) Length = 590 Score = 45.8 bits (107), Expect = 1e-04 Identities = 45/161 (27%), Positives = 67/161 (41%), Gaps = 3/161 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGR-RLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +R R LGKGGFG V + R TG ++ IK S N E + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN-----EKQILEK 240 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDML--GPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 + V + Y D +++ ++ G + +N+ E AAE + L Sbjct: 241 VNSRF-VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 E +H + V+ D+KPEN LL G + + DLGLA K Sbjct: 300 EDLHHENIVYRDLKPENILLDDYG-----HIRISDLGLAVK 335
>CBK1_CANGA (Q6FP74) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 773 Score = 45.8 bits (107), Expect = 1e-04 Identities = 40/163 (24%), Positives = 71/163 (43%), Gaps = 5/163 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS- 275 ++ + +GKG FG V + ++ G A + +K E Y HV + Sbjct: 369 DFHTVQVIGKGAFGEVRLVQKKDTGK---IYAMKTLLKSEM-------YKKDQLAHVKAE 418 Query: 276 --ALGGTHG--VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 L GT + ++Y + Y +IM+ L + + Q + ++ AE I Sbjct: 419 RDVLAGTDSPWIVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECI 478 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 +E++H G++H D+KP+N L+ G + L D GL+T Sbjct: 479 LAIETIHKLGFIHRDIKPDNILIDIRG-----HIKLSDFGLST 516
>ROCK2_HUMAN (O75116) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2) Length = 1388 Score = 45.8 bits (107), Expect = 1e-04 Identities = 46/171 (26%), Positives = 73/171 (42%), Gaps = 1/171 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y V + +G+G FG V + R + A ++ KFE K + +E A Sbjct: 91 DYDVVKVIGRGAFGEVQLVRHKAS---QKVYAMKLLSKFE--MIKRSDSAFFWEERDIMA 145 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNL-AGQTMSSEMVACIAAEAISILE 455 + V ++ Y + Y M+M+ + D NL + + + AE + L+ Sbjct: 146 FANSPWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWAKFYTAEVVLALD 203 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVD 608 ++HS G +H DVKP+N LL + G L L D G K D H D Sbjct: 204 AIHSMGLIHRDVKPDNMLLDKHG-----HLKLADFGTCMK-MDETGMVHCD 248
>CBK1_PNECA (Q6TGC6) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 507 Score = 45.4 bits (106), Expect = 1e-04 Identities = 38/162 (23%), Positives = 71/162 (43%), Gaps = 5/162 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS- 275 ++ + +GKG FG V + +++ G A + +K E + HV + Sbjct: 125 DFHTVKVIGKGAFGEVRLVQKIDTGK---IYAMKTLLKSEM-------FKKDQLAHVKAE 174 Query: 276 ----ALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 A + V ++Y + Y +IM+ L + + T S ++ AE I Sbjct: 175 RDVLAESDSPWVVSLYYSFQDSQYLYLIMEFLPGGDLMTMLIKYDTFSEDVTRFYIAECI 234 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 +E++H G++H D+KP+N L+ + G + L D GL+ Sbjct: 235 LAIEAVHKLGFIHRDIKPDNILIDKTG-----HIKLSDFGLS 271
>GRK5_RAT (Q62833) G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK5) Length = 590 Score = 45.4 bits (106), Expect = 1e-04 Identities = 45/161 (27%), Positives = 67/161 (41%), Gaps = 3/161 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGR-RLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +R R LGKGGFG V + R TG ++ IK S N E + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN-----EKQILEK 240 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDML--GPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 + V + Y D +++ ++ G + +N+ E AAE + L Sbjct: 241 VNSQF-VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 E +H + V+ D+KPEN LL G + + DLGLA K Sbjct: 300 EDLHRENTVYRDLKPENILLDDYG-----HIRISDLGLAVK 335
>GRK5_MOUSE (Q8VEB1) G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK5) Length = 590 Score = 45.4 bits (106), Expect = 1e-04 Identities = 45/161 (27%), Positives = 67/161 (41%), Gaps = 3/161 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGR-RLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +R R LGKGGFG V + R TG ++ IK S N E + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN-----EKQILEK 240 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDML--GPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 + V + Y D +++ ++ G + +N+ E AAE + L Sbjct: 241 VNSQF-VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 E +H + V+ D+KPEN LL G + + DLGLA K Sbjct: 300 EDLHRENTVYRDLKPENILLDDYG-----HIRISDLGLAVK 335
>GRK5_HUMAN (P34947) G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK5) Length = 590 Score = 45.4 bits (106), Expect = 1e-04 Identities = 45/161 (27%), Positives = 67/161 (41%), Gaps = 3/161 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGR-RLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +R R LGKGGFG V + R TG ++ IK S N E + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN-----EKQILEK 240 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDML--GPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 + V + Y D +++ ++ G + +N+ E AAE + L Sbjct: 241 VNSQF-VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 E +H + V+ D+KPEN LL G + + DLGLA K Sbjct: 300 EDLHRENTVYRDLKPENILLDDYG-----HIRISDLGLAVK 335
>CBK1_DEBHA (Q6BLJ9) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 716 Score = 45.4 bits (106), Expect = 1e-04 Identities = 42/164 (25%), Positives = 72/164 (43%), Gaps = 6/164 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHV-FVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 ++ + +GKG FG V V +R TG A + +K E Y HV + Sbjct: 314 DFNTVKVIGKGAFGEVRLVQKRDTGK----IYAMKTLLKSEM-------YKKDQLAHVKA 362 Query: 276 ---ALGGTHG--VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEA 440 L G+ V ++Y + Y +IM+ L + + Q + ++ AE Sbjct: 363 ERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQIFTEDITRFYMAEC 422 Query: 441 ISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 + +E++H G++H D+KP+N L+ G + L D GL+T Sbjct: 423 VLAIEAIHKLGFIHRDIKPDNILIDIRG-----HIKLSDFGLST 461
>CBK1_YEAST (P53894) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1) (Cell| wall biosynthesis kinase) Length = 756 Score = 45.1 bits (105), Expect = 2e-04 Identities = 40/163 (24%), Positives = 71/163 (43%), Gaps = 5/163 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS- 275 ++ + +GKG FG V + ++ G A + +K E Y HV + Sbjct: 351 DFHTVKVIGKGAFGEVRLVQKKDTGK---IYAMKTLLKSEM-------YKKDQLAHVKAE 400 Query: 276 --ALGGTHG--VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 L G+ V ++Y + Y +IM+ L + + Q + ++ AE I Sbjct: 401 RDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECI 460 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 +E++H G++H D+KP+N L+ G + L D GL+T Sbjct: 461 LAIETIHKLGFIHRDIKPDNILIDIRG-----HIKLSDFGLST 498
>CBK1_ASHGO (Q754N7) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 719 Score = 45.1 bits (105), Expect = 2e-04 Identities = 40/163 (24%), Positives = 71/163 (43%), Gaps = 5/163 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS- 275 ++ + +GKG FG V + ++ G A + +K E Y HV + Sbjct: 309 DFHTVKVIGKGAFGEVRLVQKKDTGK---IYAMKTLLKSEM-------YKKDQLAHVKAE 358 Query: 276 --ALGGTHG--VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 L G+ V ++Y + Y +IM+ L + + Q + ++ AE I Sbjct: 359 RDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQIFTEDVTRFYMAECI 418 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 +E++H G++H D+KP+N L+ G + L D GL+T Sbjct: 419 LAIEAIHKLGFIHRDIKPDNILIDIRG-----HIKLSDFGLST 456
>PKND_MYCTU (O05871) Serine/threonine-protein kinase pknD (EC 2.7.11.1)| Length = 664 Score = 45.1 bits (105), Expect = 2e-04 Identities = 44/166 (26%), Positives = 66/166 (39%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 Y++ R LG+GG G V+ R + ++ ++ N E L Sbjct: 15 YQLLRLLGRGGMGEVYEAEDTR--KHRVVALKLISPQYSDNAVFRARM--QREADTAGRL 70 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 H VP Y G ++V + + G SL G + VA I + + L++ Sbjct: 71 TEPHIVPIHDYGEINGQFFVEMRMIDGTSLRALLKQYGPLTPARAVA-IVRQIAAALDAA 129 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 H+ G H DVKPEN L+ +LVD G+A DP Q Sbjct: 130 HANGVTHRDVKPENILV-----TASDFAYLVDFGIARAASDPGLTQ 170
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 45.1 bits (105), Expect = 2e-04 Identities = 43/176 (24%), Positives = 83/176 (47%), Gaps = 2/176 (1%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + LG+G +G VF+ R++ G + A +V K E + + Sbjct: 58 QFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVR--SKMERDILAE 115 Query: 279 LGGTHGVPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTM-SSEMVACIAAEAISIL 452 + + K+HY + +G Y+++ + G L+ L+ + M + E V AE L Sbjct: 116 VNHPF-IVKLHYAFQTEGKLYLILDFLRGGDLFT--RLSKEVMFTEEDVKFYLAELALAL 172 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQR 620 + +HS G ++ D+KPEN LL + G + + D GL +++ +D+D+R Sbjct: 173 DHLHSLGIIYRDLKPENILLDEEG-----HIKITDFGL--------SKEAIDHDKR 215 Score = 31.6 bits (70), Expect = 2.0 Identities = 22/83 (26%), Positives = 41/83 (49%), Gaps = 2/83 (2%) Frame = +3 Query: 327 GDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPEN 503 G + ++M+++ G L D L + S + + ++ +HS+G VH D+KP N Sbjct: 479 GKFVYLVMELMRGGELLDRI-LRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSN 537 Query: 504 FLL-GQPGTPQEKKLFLVDLGLA 569 L + G+P+ + + D G A Sbjct: 538 ILYRDESGSPE--SIRVCDFGFA 558
>PIM2_MOUSE (Q62070) Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1)| Length = 370 Score = 45.1 bits (105), Expect = 2e-04 Identities = 42/149 (28%), Positives = 65/149 (43%), Gaps = 11/149 (7%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIK-FEHNTSKGC-----NYGPPYE 260 EYR+ LGKGGFG VF G R+T ++VAIK N G + P E Sbjct: 90 EYRLGPLLGKGGFGTVFAGHRVT-------DRRQVAIKVISRNRVLGWSTVSDSVTCPLE 142 Query: 261 WHVYSALGGTHGVPKV-----HYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVAC 425 + +G +G P V ++ +G V+ M L+D G + Sbjct: 143 VALLWKVGEGNGHPGVIRLLDWFETPEGFMLVLERPMPAQDLFDYITEKG-PLGESCSRS 201 Query: 426 IAAEAISILESMHSKGYVHGDVKPENFLL 512 + ++ ++ H++G VH D+K EN L+ Sbjct: 202 FFTQVVAAVQHCHARGVVHRDIKDENILI 230
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 44.7 bits (104), Expect = 2e-04 Identities = 41/164 (25%), Positives = 77/164 (46%), Gaps = 2/164 (1%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + LG+G +G VF+ R++TG + A +V K E + + Sbjct: 58 QFELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVR--SKMERDILAE 115 Query: 279 LGGTHGVPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTM-SSEMVACIAAEAISIL 452 + + K+HY + +G Y+++ + G L+ L+ + M + E V AE L Sbjct: 116 VNHPF-IVKLHYAFQTEGKLYLILDFLRGGDLFT--RLSKEVMFTEEDVKFYLAELALAL 172 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKD 584 + +H G ++ D+KPEN LL + G + + D GL+ + D Sbjct: 173 DHLHGLGIIYRDLKPENILLDEEG-----HIKITDFGLSKEATD 211 Score = 34.3 bits (77), Expect = 0.31 Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 3/84 (3%) Frame = +3 Query: 327 GDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAIS-ILESMHSKGYVHGDVKPE 500 G Y ++M+++ G L D + Q SE A I+ ++ +HS+G VH D+KP Sbjct: 479 GKYVYLVMELMRGGELLD--RILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPS 536 Query: 501 NFL-LGQPGTPQEKKLFLVDLGLA 569 N L + + G P+ + + D G A Sbjct: 537 NILYMDESGNPE--SIRICDFGFA 558
>KS6B2_HUMAN (Q9UBS0) Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2)| (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serin Length = 482 Score = 44.7 bits (104), Expect = 2e-04 Identities = 42/156 (26%), Positives = 70/156 (44%), Gaps = 1/156 (0%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + + R LGKGG+G VF R++ G N A +V K + + E ++ ++ Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACI-AAEAISILES 458 V + G Y+++ + G L+ +L + + E AC AE L Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFT--HLEREGIFLEDTACFYLAEITLALGH 184 Query: 459 MHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGL 566 +HS+G ++ D+KPEN +L G + L D GL Sbjct: 185 LHSQGIIYRDLKPENIMLSSQG-----HIKLTDFGL 215
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 44.7 bits (104), Expect = 2e-04 Identities = 44/170 (25%), Positives = 71/170 (41%), Gaps = 6/170 (3%) Frame = +3 Query: 78 VQIGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF--EHNTSKGCNYGP 251 V+ G E+ + +G G F VF GR R EVA+K + N +K Sbjct: 8 VETVGKFEFSRKDLIGHGAFAVVFKGRH------REKHDLEVAVKCINKKNLAKSQTLLG 61 Query: 252 PYEWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIA 431 E + L + V ++ Y+++ G L D + +T+S + V Sbjct: 62 K-EIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTM-RTLSEDTVRLFL 119 Query: 432 AEAISILESMHSKGYVHGDVKPENFLLGQPG----TPQEKKLFLVDLGLA 569 + + +HSKG +H D+KP+N LL PG P ++ + D G A Sbjct: 120 QQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFA 169
>MDE3_SCHPO (O43077) Sporulation protein kinase mde3 (EC 2.7.11.1)| (Mei4-dependent protein 3) Length = 559 Score = 44.7 bits (104), Expect = 2e-04 Identities = 42/175 (24%), Positives = 74/175 (42%), Gaps = 11/175 (6%) Frame = +3 Query: 72 DTVQIGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGP 251 D Q+ Y V++KLG G FG V++ +R + + VA+K N+SK Sbjct: 11 DLTQVIFEDRYLVKQKLGDGSFGTVYLAQR----KEKNGLYETVAVKKLKNSSK------ 60 Query: 252 PYEWHVYSALGGTHGVPKVHYKGRQGDYY----------VMIMDMLGPSLWDSWNLA-GQ 398 P H L + + K+ D ++M+ + +L+ + G+ Sbjct: 61 PKPKHELLKLRESLALRKISKHPCLIDLLETFMDPYRNIFLVMEFMDCNLFQLFKRRQGR 120 Query: 399 TMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLG 563 + E I + IS +E +H G++H D+KPEN L+ + + + LG Sbjct: 121 LFTKETAFNILLQIISGIEHIHKHGFMHRDIKPENILVKRISPKPISSRYSIKLG 175
>PKN1_MYXXA (P33973) Serine/threonine-protein kinase pkn1 (EC 2.7.11.1)| Length = 693 Score = 44.7 bits (104), Expect = 2e-04 Identities = 39/162 (24%), Positives = 74/162 (45%), Gaps = 6/162 (3%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA- 278 +R+ R+LG+GG G V++G ++ G+ VA+K H P ++ Sbjct: 59 FRLVRRLGRGGMGAVYLGEHVSIGS-------RVAVKVLH---AHLTMYPELVQRFHAEA 108 Query: 279 ----LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAIS 446 L G + + +IM+ L + +W G +++ V + ++ Sbjct: 109 RAVNLIGHENIVSIFDMDATPPRPYLIMEFLDGAPLSAW--VGTPLAAGAVVSVLSQVCD 166 Query: 447 ILESMHSKGYVHGDVKPEN-FLLGQPGTPQEKKLFLVDLGLA 569 L++ H++G VH D+KP+N FL+ + G K ++D G+A Sbjct: 167 ALQAAHARGIVHRDLKPDNIFLVRRNGNAPFVK--VLDFGIA 206
>CDPK_SOYBN (P28583) Calcium-dependent protein kinase SK5 (EC 2.7.11.1) (CDPK)| Length = 508 Score = 44.7 bits (104), Expect = 2e-04 Identities = 45/165 (27%), Positives = 67/165 (40%), Gaps = 5/165 (3%) Frame = +3 Query: 102 YRVERKLGKGGFGHVF-VGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWH---V 269 Y V RKLG+G FG F RR +GG + A K C W + Sbjct: 34 YEVGRKLGQGQFGTTFECTRRASGG--------KFACKSIPKRKLLCKEDYEDVWREIQI 85 Query: 270 YSALGGTHGVPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAIS 446 L V ++ ++M++ G L+D G S A + + Sbjct: 86 MHHLSEHANVVRIEGTYEDSTAVHLVMELCEGGELFDRIVQKGH-YSERQAARLIKTIVE 144 Query: 447 ILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 ++E+ HS G +H D+KPENFL ++ KL D GL+ +K Sbjct: 145 VVEACHSLGVMHRDLKPENFLFDT--IDEDAKLKATDFGLSVFYK 187
>MRCKA_RAT (O54874) Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1)| (CDC42-binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) Length = 1732 Score = 44.3 bits (103), Expect = 3e-04 Identities = 40/168 (23%), Positives = 69/168 (41%), Gaps = 1/168 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + +G+G FG V V + N A ++ K+E K E Sbjct: 76 DFEILKVIGRGAFGEVAVVKLK---NADKVFAMKILNKWE--MLKRAETACFREERDVLV 130 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDM-LGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 G + + +HY + + ++MD +G L + + EM AE + ++ Sbjct: 131 NGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAID 190 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 S+H YVH D+KP+N L+ G + L D G K + T Q Sbjct: 191 SVHQLHYVHRDIKPDNILMDMNG-----HIRLADFGSCLKLMEDGTVQ 233
>MRCKB_HUMAN (Q9Y5S2) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1711 Score = 44.3 bits (103), Expect = 3e-04 Identities = 40/168 (23%), Positives = 68/168 (40%), Gaps = 1/168 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + +G+G FG V V + N A ++ K+E K E Sbjct: 75 DFEIIKVIGRGAFGEVAVVKMK---NTERIYAMKILNKWE--MLKRAETACFREERDVLV 129 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDM-LGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 G + +HY + ++ ++MD +G L + + +M E + ++ Sbjct: 130 NGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAID 189 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 S+H YVH D+KP+N LL G + L D G K D T Q Sbjct: 190 SIHQLHYVHRDIKPDNVLLDVNG-----HIRLADFGSCLKMNDDGTVQ 232
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 43.9 bits (102), Expect = 4e-04 Identities = 40/144 (27%), Positives = 69/144 (47%), Gaps = 2/144 (1%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + LG+G FG VF+ R++ G + A +V K E ++ + Sbjct: 103 QFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRD--RQRTKLERNILAH 160 Query: 279 LGGTHGVPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTMSSEM-VACIAAEAISIL 452 + + K+HY + +G Y+++ + G L+ L+ + M +E V AE L Sbjct: 161 ISHPF-IVKLHYAFQTEGKLYLILDFLRGGDLFT--RLSKEVMFTEDDVKFYLAELTLAL 217 Query: 453 ESMHSKGYVHGDVKPENFLLGQPG 524 E +HS G V+ D+KPEN LL G Sbjct: 218 EHLHSLGIVYRDLKPENILLDADG 241
>PMYT1_DROME (Q9NI63) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) (dMyt1) Length = 533 Score = 43.9 bits (102), Expect = 4e-04 Identities = 41/152 (26%), Positives = 64/152 (42%), Gaps = 2/152 (1%) Frame = +3 Query: 117 KLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPY--EWHVYSALGGT 290 KLG+G FG VF R + G Q A+K +G Y E Y G Sbjct: 107 KLGEGSFGEVFQVRDRSDG-------QLYAVKISKQLFRGEQYRAERLEEVRRYEEFSGH 159 Query: 291 HGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSK 470 + Q D M M++ SL + + L Q + E + I + + L+S+H + Sbjct: 160 ENCIRFIRAWEQYDRLYMQMELCRESL-EQYLLRCQRIPEERIWHILLDLLRGLKSLHDR 218 Query: 471 GYVHGDVKPENFLLGQPGTPQEKKLFLVDLGL 566 +H D+K +N L+G+ ++ L D GL Sbjct: 219 NLIHLDIKLDNVLIGE----DDETCKLADFGL 246
>KRB2_VACCC (P21098) Probable serine/threonine-protein kinase B12 (EC 2.7.11.1)| Length = 283 Score = 43.9 bits (102), Expect = 4e-04 Identities = 29/107 (27%), Positives = 50/107 (46%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGY 476 +P ++ G DY ++ LG A + S AC+ I+ LE +HS+G+ Sbjct: 84 IPDLYGIGETDDYMFFVIKNLGRVF------APKDTESVFEACVTM--INTLEFIHSRGF 135 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQ 617 HG ++P N L+ + K+L L+D K + H+DY++ Sbjct: 136 THGKIEPRNILI------RNKRLSLIDYSRTNKLY-KSGNSHIDYNE 175
>KRB2_VACCA (O57259) Probable serine/threonine-protein kinase B12 (EC 2.7.11.1)| Length = 283 Score = 43.9 bits (102), Expect = 4e-04 Identities = 29/107 (27%), Positives = 50/107 (46%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGY 476 +P ++ G DY ++ LG A + S AC+ I+ LE +HS+G+ Sbjct: 84 IPDLYGIGETDDYMFFVIKNLGRVF------APKDTESVFEACVTM--INTLEFIHSRGF 135 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQ 617 HG ++P N L+ + K+L L+D K + H+DY++ Sbjct: 136 THGKIEPRNILI------RNKRLSLIDYSRTNKLY-KSGNSHIDYNE 175
>CBK1_KLULA (P31034) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 718 Score = 43.9 bits (102), Expect = 4e-04 Identities = 40/163 (24%), Positives = 70/163 (42%), Gaps = 5/163 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS- 275 ++ + +GKG FG V + ++ G A + +K E Y HV + Sbjct: 302 DFNSVKVIGKGAFGEVRLVQKKDTGK---IYAMKTLLKSEM-------YNKDQLAHVKAE 351 Query: 276 --ALGGTHG--VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 L G+ V ++Y + Y +IM+ L + + Q + ++ AE I Sbjct: 352 RDVLAGSDSPWVVSLYYSFQDSQYLYLIMEFLPGGDLMTMLIRWQIFTEDVTRFYMAECI 411 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 +E +H G++H D+KP+N L+ G + L D GL+T Sbjct: 412 LAIEVIHKLGFIHRDIKPDNILIDIRG-----HIKLSDFGLST 449
>KRB2_VACCV (P24362) Probable serine/threonine-protein kinase B12 (EC 2.7.11.1)| Length = 283 Score = 43.5 bits (101), Expect = 5e-04 Identities = 29/107 (27%), Positives = 50/107 (46%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGY 476 +P ++ G DY ++ LG A + S AC+ I+ LE +HS+G+ Sbjct: 84 IPDLYGIGETDDYMFFVIKNLGRVF------APKDTESVFEACVTM--INTLEFIHSQGF 135 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQ 617 HG ++P N L+ + K+L L+D K + H+DY++ Sbjct: 136 THGKIEPRNILI------RNKRLSLIDYSRTNKLY-KSGNSHIDYNE 175
>KS6B2_MOUSE (Q9Z1M4) Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta| 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2) Length = 485 Score = 43.5 bits (101), Expect = 5e-04 Identities = 42/150 (28%), Positives = 66/150 (44%), Gaps = 1/150 (0%) Frame = +3 Query: 120 LGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSALGGTHGV 299 LGKGG+G VF R++ G N A +V K + S E ++ ++ V Sbjct: 73 LGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCSAKDTAHTRAERNILESVKHPFIV 132 Query: 300 PKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACI-AAEAISILESMHSKGY 476 + G Y+++ + G L+ +L + + E AC AE L +HS G Sbjct: 133 ELAYAFQTGGKLYLILECLSGGELFT--HLEREGIFLEDTACFYLAEITLALGHLHSHGI 190 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGL 566 ++ D+KPEN +L G + L D GL Sbjct: 191 IYRDLKPENIMLSSQG-----HIKLTDFGL 215
>GRK1_CAEEL (Q09537) G protein-coupled receptor kinase 1 (EC 2.7.11.16)| Length = 642 Score = 43.5 bits (101), Expect = 5e-04 Identities = 44/164 (26%), Positives = 72/164 (43%), Gaps = 3/164 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGR-RLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +R+ R LGKGGFG V + R +G ++ +K H + N E + Sbjct: 203 FRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSLN-----EKQILQR 257 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDML--GPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 + V + Y D +++ ++ G + +NL + V AAE L Sbjct: 258 INSPF-VVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLMPGGFDEKRVQFYAAEITLGL 316 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKD 584 + +HS+ ++ D+KPEN LL G + + DLGLA + KD Sbjct: 317 QHLHSERILYRDLKPENILLDDFG-----HVRISDLGLAVEIKD 355
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 43.5 bits (101), Expect = 5e-04 Identities = 43/159 (27%), Positives = 75/159 (47%), Gaps = 2/159 (1%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + LG+G FG VF+ R++T + A +V K E + + Sbjct: 79 QFELLKVLGQGSFGKVFLVRKITPPDSNHLYAMKVLKKATLKVRDRVR--TKIERDILAD 136 Query: 279 LGGTHGVPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTM-SSEMVACIAAEAISIL 452 + V K+HY + +G Y+++ + G L+ L+ + M + E V AE L Sbjct: 137 VNHPF-VVKLHYAFQTEGKLYLILDFLRGGDLFT--RLSKEVMFTEEDVKFYLAELALGL 193 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 + +HS G ++ D+KPEN LL + G + L D GL+ Sbjct: 194 DHLHSLGIIYRDLKPENILLDEEG-----HIKLTDFGLS 227 Score = 33.5 bits (75), Expect = 0.52 Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 3/84 (3%) Frame = +3 Query: 327 GDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAI-SILESMHSKGYVHGDVKPE 500 G Y ++ +++ G L D + Q SE A I +E +HS+G VH D+KP Sbjct: 499 GKYVYLVTELMRGGELLDK--ILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKPS 556 Query: 501 NFL-LGQPGTPQEKKLFLVDLGLA 569 N L + + G P+ + + D G A Sbjct: 557 NILYVDESGNPE--SIRICDFGFA 578
>ORB6_SCHPO (O13310) Serine/threonine-protein kinase orb6 (EC 2.7.11.1)| Length = 469 Score = 43.1 bits (100), Expect = 7e-04 Identities = 25/92 (27%), Positives = 44/92 (47%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGY 476 V ++Y + Y +IM+ L + + T S ++ AE + + +H GY Sbjct: 153 VVSLYYAFQDSLYLYLIMEFLPGGDLMTMLINYDTFSEDVTRFYMAECVLAIADVHRMGY 212 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 +H D+KP+N L+ + G + L D GL+T Sbjct: 213 IHRDIKPDNILIDRDG-----HIKLSDFGLST 239
>PKNA2_BIFLO (Q8G4G1) Probable serine/threonine-protein kinase pknA2 (EC| 2.7.11.1) Length = 757 Score = 43.1 bits (100), Expect = 7e-04 Identities = 44/167 (26%), Positives = 67/167 (40%), Gaps = 11/167 (6%) Frame = +3 Query: 102 YRVERKLGKGGFGHVF------VGRRLT-----GGNGRGAGAQEVAIKFEHNTSKGCNYG 248 YR+ R + +GG V+ +GR + +G ++ +F + + Sbjct: 14 YRIVRNIAEGGMATVYEAIDERLGRTVAIKVMHTQLAKGPHREQFVERFRREANSAASIA 73 Query: 249 PPYEWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACI 428 P+ VY G +G+ D+ VM + G +L N G T S + Sbjct: 74 NPHIVQVYDT-GEFNGL----------DFLVMEY-VHGVNLRHEMNAQG-TFSVRETLRV 120 Query: 429 AAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 AE + L S H G VH D+KPEN L+ G Q + D GLA Sbjct: 121 VAETLDGLASAHRAGVVHRDIKPENILINDRGHVQ-----ITDFGLA 162
>PK2_DICDI (P28178) Protein kinase 2 (EC 2.7.11.1)| Length = 479 Score = 43.1 bits (100), Expect = 7e-04 Identities = 29/94 (30%), Positives = 46/94 (48%), Gaps = 1/94 (1%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKG 473 + +HY + D M++D + G L+ G+ S V AAE +S L+ +H + Sbjct: 213 IVNLHYAFQTKDKLYMVLDFVNGGELFFHLKREGR-FSEPRVKIYAAEIVSALDHLHKQD 271 Query: 474 YVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 V+ D+KPEN LL G + + D GL+ K Sbjct: 272 IVYRDLKPENILLDSEG-----HICITDFGLSKK 300
>AFSK_STRCO (P54741) Serine/threonine protein kinase afsK (EC 2.7.11.1)| Length = 799 Score = 43.1 bits (100), Expect = 7e-04 Identities = 40/157 (25%), Positives = 67/157 (42%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + V +LG GG G V++ R +GR + V + + + E A+ Sbjct: 16 FEVLGRLGAGGMGLVYLAR---SASGRRVAIKTVRTELAEDQLFRVRFTREVE--AARAV 70 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 G + V R ++ + PSL + N G M ++ V +AA L+S+ Sbjct: 71 SGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIVNECGP-MPAQAVRWLAAGVAEALQSI 129 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 H G VH D+KP N L+ + G ++D G+A+ Sbjct: 130 HGAGLVHRDLKPSNVLVVEDGPR------VIDFGIAS 160
>PKAA_STRCO (P54739) Serine/threonine protein kinase pkaA (EC 2.7.11.1)| Length = 543 Score = 43.1 bits (100), Expect = 7e-04 Identities = 48/176 (27%), Positives = 75/176 (42%), Gaps = 8/176 (4%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGA----QEVAIK-FEHNTSKGCNYGPPYEW 263 +Y +E LG+G G V+ R+ A A + VAIK + + + + Sbjct: 7 KYLLEEPLGRGATGTVWRARQRETAGAEAAVAGQPGETVAIKVLKEELASDADIVMRFLR 66 Query: 264 HVYSALGGTH-GVPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAE 437 L TH + +V +G+ ++MD++ GP L G ++ A + A+ Sbjct: 67 ERSVLLRLTHPNIVRVRDLVVEGELLALVMDLIDGPDLHRYLRENGP-LTPVAAALLTAQ 125 Query: 438 AISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPA-TQQH 602 L + H+ G VH D+KP N LL Q G E L D G+A P T+ H Sbjct: 126 IADALAASHADGVVHRDLKPANVLLKQTG--GEMHPMLTDFGIARLADSPGLTRTH 179
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 43.1 bits (100), Expect = 7e-04 Identities = 38/141 (26%), Positives = 64/141 (45%), Gaps = 2/141 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNT--SKGCNYGPPYEWHVYS 275 Y++ + LG+G FG V + +T G Q+VA+K + +K G Y Sbjct: 39 YQIVKTLGEGSFGKVKLAYHVTTG-------QKVALKIINKKVLAKSDMQGRIEREISYL 91 Query: 276 ALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 L + K++ + D +M+++ G L+D + + MS + + IS +E Sbjct: 92 RLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFD-YIVQRNKMSEQEARRFFQQIISAVE 150 Query: 456 SMHSKGYVHGDVKPENFLLGQ 518 H VH D+KPEN LL + Sbjct: 151 YCHRHKIVHRDLKPENLLLDE 171
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 43.1 bits (100), Expect = 7e-04 Identities = 38/143 (26%), Positives = 61/143 (42%), Gaps = 1/143 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y V +G+G FG V+ GRR AQ VA+KF + + + Sbjct: 3 KYHVLEMIGEGSFGRVYKGRRKYS-------AQVVALKFIPKLGRSEKELRNLQREIEIM 55 Query: 279 LGGTH-GVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 G H + + V++ D L+ G+ + + V IAA+ +S L Sbjct: 56 RGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGK-LPEDQVQAIAAQLVSALY 114 Query: 456 SMHSKGYVHGDVKPENFLLGQPG 524 +HS +H D+KP+N LL + G Sbjct: 115 YLHSHRILHRDMKPQNILLAKGG 137
>PKNH_MYCTU (Q11053) Probable serine/threonine-protein kinase pknH (EC| 2.7.11.1) Length = 626 Score = 42.7 bits (99), Expect = 9e-04 Identities = 44/169 (26%), Positives = 66/169 (39%), Gaps = 3/169 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF---EHNTSKGCNYGPPYEWHVY 272 Y ++R LG+GG G V+ VA+K E + E + Sbjct: 16 YHLKRLLGRGGMGEVYEAEHTVK-------EWTVAVKLMTAEFSKDPVFRERMKREARIA 68 Query: 273 SALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 L H VP Y G ++ + + G L G VA I A S L Sbjct: 69 GRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTDLDSVLKRFGPLTPPRAVAIITQIA-SAL 127 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 ++ H+ G +H DVKP+N L+ ++ +LVD G+A+ D Q Sbjct: 128 DAAHADGVMHRDVKPQNILI-----TRDDFAYLVDFGIASATTDEKLTQ 171
>LATS2_MOUSE (Q7TSJ6) Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large| tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) Length = 1042 Score = 42.7 bits (99), Expect = 9e-04 Identities = 25/95 (26%), Positives = 43/95 (45%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGY 476 V K++Y + D +MD + S + + + AE +ES+H G+ Sbjct: 686 VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF 745 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 +H D+KP+N L+ G + L D GL T ++ Sbjct: 746 IHRDIKPDNILIDLDG-----HIKLTDFGLCTGFR 775
>AFSK_STRGR (P54742) Serine/threonine protein kinase afsK (EC 2.7.11.1)| Length = 807 Score = 42.7 bits (99), Expect = 9e-04 Identities = 40/157 (25%), Positives = 67/157 (42%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + V +LG GG G V++ R +GR + V + + + E A+ Sbjct: 16 FEVLGRLGAGGMGLVYLAR---SASGRRVAIKTVRTELAEDQLFRVRFTREVE--AARAV 70 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 G + V R ++ + PSL + N G M ++ V +AA L+S+ Sbjct: 71 SGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIVNECGP-MPTQAVRWLAAGIAQALQSI 129 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 H G VH D+KP N L+ + G ++D G+A+ Sbjct: 130 HGAGLVHRDLKPSNVLVVEDGPR------VIDFGIAS 160
>MRCKA_HUMAN (Q5VT25) Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1)| (CDC42-binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha Length = 1732 Score = 42.7 bits (99), Expect = 9e-04 Identities = 39/168 (23%), Positives = 68/168 (40%), Gaps = 1/168 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + +G+G FG V V + N A ++ K+E K E Sbjct: 76 DFEILKVIGRGAFGEVAVVKLK---NADKVFAMKILNKWE--MLKRAETACFREERDVLV 130 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDM-LGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 G + +HY + + ++MD +G L + + +M AE + ++ Sbjct: 131 NGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAID 190 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 S+H YVH D+KP+N L+ G + L D G K + T Q Sbjct: 191 SVHQLHYVHRDIKPDNILMDMNG-----HIRLADFGSCLKLMEDGTVQ 233
>BUB1_MOUSE (O08901) Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC| 2.7.11.1) (MBUB1) (BUB1A) Length = 1058 Score = 42.7 bits (99), Expect = 9e-04 Identities = 23/71 (32%), Positives = 37/71 (52%), Gaps = 5/71 (7%) Frame = +3 Query: 384 NLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKK-----LF 548 N + + M +V A + ++E +HS +HGD+KP+NF+LG Q + L Sbjct: 857 NTSEKVMPQALVLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILGHRFLEQADEDLATGLA 916 Query: 549 LVDLGLATKWK 581 L+DLG + K Sbjct: 917 LIDLGQSIDMK 927
>KAPC_ASCSU (P49673) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 337 Score = 42.7 bits (99), Expect = 9e-04 Identities = 26/78 (33%), Positives = 41/78 (52%) Frame = +3 Query: 336 YVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFLLG 515 Y++ + G L+ S+ A +T S+ M AAE + L+ +HSK + D+KPEN +L Sbjct: 103 YMLFEYLAGGELF-SYLRASRTFSNSMARFYAAEIVCALQYLHSKNIAYRDLKPENLMLN 161 Query: 516 QPGTPQEKKLFLVDLGLA 569 + G L + D G A Sbjct: 162 KEG-----HLKMTDFGFA 174
>PKNH_MYCBO (Q7U095) Probable serine/threonine-protein kinase pknH (EC| 2.7.11.1) Length = 596 Score = 42.7 bits (99), Expect = 9e-04 Identities = 44/169 (26%), Positives = 66/169 (39%), Gaps = 3/169 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF---EHNTSKGCNYGPPYEWHVY 272 Y ++R LG+GG G V+ VA+K E + E + Sbjct: 16 YHLKRLLGRGGMGEVYEAEHTVK-------EWTVAVKLMTAEFSKDPVFRERMKREARIA 68 Query: 273 SALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 L H VP Y G ++ + + G L G VA I A S L Sbjct: 69 GRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTDLDSVLKRFGPLTPPRAVAIITQIA-SAL 127 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 ++ H+ G +H DVKP+N L+ ++ +LVD G+A+ D Q Sbjct: 128 DAAHADGVMHRDVKPQNILI-----TRDDFAYLVDFGIASATTDEKLTQ 171
>ROCK2_BOVIN (Q28021) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) Length = 1388 Score = 42.7 bits (99), Expect = 9e-04 Identities = 45/171 (26%), Positives = 72/171 (42%), Gaps = 1/171 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y V + +G+G FG V + R + A ++ KFE K + +E A Sbjct: 91 DYDVVKVIGRGAFGEVQLVRHKAS---QKVYAMKLLSKFE--MIKRSDSAFFWEERDIMA 145 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNL-AGQTMSSEMVACIAAEAISILE 455 + V ++ + Y M+M+ + D NL + + + AE + L+ Sbjct: 146 FANSPWVVQLFCAFQDDKYLYMVMEYMPGG--DLVNLMSNYDVPEKWAKFYTAEVVLALD 203 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVD 608 ++HS G +H DVKP+N LL + G L L D G K D H D Sbjct: 204 AIHSMGLIHRDVKPDNMLLDKHG-----HLKLADFGTCMK-MDETGMVHCD 248
>CSK22_MOUSE (O54833) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 350 Score = 42.7 bits (99), Expect = 9e-04 Identities = 44/175 (25%), Positives = 76/175 (43%), Gaps = 2/175 (1%) Frame = +3 Query: 87 GGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWH 266 G +Y++ RKLG+G + VF +T + V +K K E Sbjct: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNN-------ERVVVKILKPVKKK---KIKREVK 84 Query: 267 VYSAL-GGTHGVPKVH-YKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEA 440 + L GGT+ + + K ++ + + + + Q ++ + E Sbjct: 85 ILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYEL 141 Query: 441 ISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHV 605 + L+ HSKG +H DVKP N ++ Q+KKL L+D GLA ++ PA + +V Sbjct: 142 LKALDYCHSKGIMHRDVKPHNVMIDH----QQKKLRLIDWGLA-EFYHPAQEYNV 191
>CSK22_HUMAN (P19784) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 350 Score = 42.7 bits (99), Expect = 9e-04 Identities = 44/175 (25%), Positives = 76/175 (43%), Gaps = 2/175 (1%) Frame = +3 Query: 87 GGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWH 266 G +Y++ RKLG+G + VF +T + V +K K E Sbjct: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNN-------ERVVVKILKPVKKK---KIKREVK 84 Query: 267 VYSAL-GGTHGVPKVH-YKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEA 440 + L GGT+ + + K ++ + + + + Q ++ + E Sbjct: 85 ILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYEL 141 Query: 441 ISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHV 605 + L+ HSKG +H DVKP N ++ Q+KKL L+D GLA ++ PA + +V Sbjct: 142 LKALDYCHSKGIMHRDVKPHNVMIDH----QQKKLRLIDWGLA-EFYHPAQEYNV 191
>CSK22_BOVIN (P20427) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 350 Score = 42.7 bits (99), Expect = 9e-04 Identities = 44/175 (25%), Positives = 76/175 (43%), Gaps = 2/175 (1%) Frame = +3 Query: 87 GGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWH 266 G +Y++ RKLG+G + VF +T + V +K K E Sbjct: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNN-------ERVVVKILKPVKKK---KIKREVK 84 Query: 267 VYSAL-GGTHGVPKVH-YKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEA 440 + L GGT+ + + K ++ + + + + Q ++ + E Sbjct: 85 ILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYEL 141 Query: 441 ISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHV 605 + L+ HSKG +H DVKP N ++ Q+KKL L+D GLA ++ PA + +V Sbjct: 142 LKALDYCHSKGIMHRDVKPHNVMIDH----QQKKLRLIDWGLA-EFYHPAQEYNV 191
>LATS2_HUMAN (Q9NRM7) Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large| tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase) Length = 1088 Score = 42.7 bits (99), Expect = 9e-04 Identities = 25/95 (26%), Positives = 43/95 (45%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGY 476 V K++Y + D +MD + S + + + AE +ES+H G+ Sbjct: 728 VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF 787 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 +H D+KP+N L+ G + L D GL T ++ Sbjct: 788 IHRDIKPDNILIDLDG-----HIKLTDFGLCTGFR 817
>ROCK2_MOUSE (P70336) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) Length = 1388 Score = 42.4 bits (98), Expect = 0.001 Identities = 45/171 (26%), Positives = 72/171 (42%), Gaps = 1/171 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y V + +G+G FG V + R + A ++ KFE K + +E A Sbjct: 91 DYDVVKVIGRGAFGEVQLVRHKAS---QKVYAMKLLSKFE--MIKRSDSAFFWEERDIMA 145 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNL-AGQTMSSEMVACIAAEAISILE 455 + V ++ + Y M+M+ + D NL + + + AE + L+ Sbjct: 146 FANSPWVVQLFCAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWAKFYTAEVVLALD 203 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVD 608 ++HS G +H DVKP+N LL + G L L D G K D H D Sbjct: 204 AIHSMGLIHRDVKPDNMLLDKHG-----HLKLADFGTCMK-MDETGMVHCD 248
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 42.4 bits (98), Expect = 0.001 Identities = 37/141 (26%), Positives = 60/141 (42%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + + R LGKG FG+V++ R R A ++ K + +G + E + + L Sbjct: 80 FEIGRPLGKGKFGNVYLAREK---KSRFIVALKILFKSQIE-KEGVEHQLRREIEIQAHL 135 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 + + +Y Q Y+++ L+ +G T + A I E L Sbjct: 136 KHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSG-TFDEQRTATIMEELSDALMYC 194 Query: 462 HSKGYVHGDVKPENFLLGQPG 524 H K +H D+KPEN LLG G Sbjct: 195 HKKKVIHRDIKPENLLLGLQG 215
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 42.4 bits (98), Expect = 0.001 Identities = 23/67 (34%), Positives = 37/67 (55%) Frame = +3 Query: 324 QGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPEN 503 +GD +V++ M G SL D + ++ + + E +S LE +HSKG +H D+K +N Sbjct: 687 KGDLWVIMEYMEGGSLTDV--VTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDN 744 Query: 504 FLLGQPG 524 LL G Sbjct: 745 ILLSMEG 751
>STE20_CANAL (Q92212) Serine/threonine-protein kinase STE20 homolog (EC 2.7.11.1)| Length = 1230 Score = 42.4 bits (98), Expect = 0.001 Identities = 22/67 (32%), Positives = 36/67 (53%) Frame = +3 Query: 324 QGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPEN 503 +GD +V++ M G SL D + M+ + + E + L+ +HSKG +H D+K +N Sbjct: 1021 KGDLWVIMEYMEGGSLTDI--VTHSVMTEGQIGVVCRETLKGLKFLHSKGVIHRDIKSDN 1078 Query: 504 FLLGQPG 524 LL G Sbjct: 1079 ILLNMDG 1085
>SNF1_YEAST (P06782) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 633 Score = 42.4 bits (98), Expect = 0.001 Identities = 38/141 (26%), Positives = 63/141 (44%), Gaps = 2/141 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNT--SKGCNYGPPYEWHVYS 275 Y++ + LG+G FG V + T G Q+VA+K + +K G Y Sbjct: 55 YQIVKTLGEGSFGKVKLAYHTTTG-------QKVALKIINKKVLAKSDMQGRIEREISYL 107 Query: 276 ALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 L + K++ + D +M+++ G L+D + + MS + + IS +E Sbjct: 108 RLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFD-YIVQRDKMSEQEARRFFQQIISAVE 166 Query: 456 SMHSKGYVHGDVKPENFLLGQ 518 H VH D+KPEN LL + Sbjct: 167 YCHRHKIVHRDLKPENLLLDE 187
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 42.4 bits (98), Expect = 0.001 Identities = 42/166 (25%), Positives = 69/166 (41%), Gaps = 6/166 (3%) Frame = +3 Query: 90 GSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF--EHNTSKGCNYGPPYEW 263 G E+ + +G G F VF GR R EVA+K + N +K E Sbjct: 12 GKFEFSRKDLIGHGAFAVVFKGRH------REKHDLEVAVKCINKKNLAKSQTLLGK-EI 64 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 + L + V ++ Y+++ G L D + A +T+S + + + Sbjct: 65 KILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLH-AMRTLSEDTIRLFLQQIA 123 Query: 444 SILESMHSKGYVHGDVKPENFLLGQP----GTPQEKKLFLVDLGLA 569 + +HSKG +H D+KP+N LL P P ++ + D G A Sbjct: 124 GAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFA 169
>KBN8_YEAST (P38070) Probable serine/threonine-protein kinase YBR028C (EC| 2.7.11.1) Length = 525 Score = 42.4 bits (98), Expect = 0.001 Identities = 25/59 (42%), Positives = 32/59 (54%) Frame = +3 Query: 399 TMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 T+ V+ AAE L +H+KG V+ D+KPEN LL Q G L L D GL+ K Sbjct: 248 TLDETTVSFYAAEISCALRFLHTKGVVYRDLKPENCLLNQRG-----HLVLTDFGLSKK 301
>ROCK2_RAT (Q62868) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) (RhoA-binding kinase 2) (p150 ROK-alpha) (ROKalpha) Length = 1379 Score = 42.4 bits (98), Expect = 0.001 Identities = 45/171 (26%), Positives = 72/171 (42%), Gaps = 1/171 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y V + +G+G FG V + R + A ++ KFE K + +E A Sbjct: 82 DYDVVKVIGRGAFGEVQLVRHKAS---QKVYAMKLLSKFE--MIKRSDSAFFWEERDIMA 136 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNL-AGQTMSSEMVACIAAEAISILE 455 + V ++ + Y M+M+ + D NL + + + AE + L+ Sbjct: 137 FANSPWVVQLFCAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWAKFYTAEVVLALD 194 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVD 608 ++HS G +H DVKP+N LL + G L L D G K D H D Sbjct: 195 AIHSMGLIHRDVKPDNMLLDKHG-----HLKLADFGTCMK-MDETGMVHCD 239
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 42.4 bits (98), Expect = 0.001 Identities = 48/178 (26%), Positives = 73/178 (41%), Gaps = 11/178 (6%) Frame = +3 Query: 81 QIGGSPE-------YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTS-KG 236 ++ G PE Y R LG G FG V R+L+ ++VAIK + +G Sbjct: 33 KLSGQPESYVNRTNYIFGRTLGAGSFGVVRQARKLSTN-------EDVAIKILLKKALQG 85 Query: 237 CNYGPPYEWHVYSALGGTHGVPKVHYKG---RQGDYYVMIMDMLGPSLWDSWNLAGQTMS 407 N + S L V +K + +Y++ G L+D G+ Sbjct: 86 NNVQLQMLYEELSILQKLSHPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTE 145 Query: 408 SEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 + V I + + +E MHSK VH D+KPEN L + L + D G+A + K Sbjct: 146 VDAVEIIV-QILGAVEYMHSKNVVHRDLKPENVLYVDKS--ENSPLVIADFGIAKQLK 200
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 42.4 bits (98), Expect = 0.001 Identities = 33/140 (23%), Positives = 64/140 (45%), Gaps = 1/140 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + LGKG FG V+ R + G A E ++N K E + S+ Sbjct: 108 DFEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQFRR----EVEIQSS 163 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAA-EAISILE 455 L + Y + Y+++ ++ L+ +L G++ +++VA + L+ Sbjct: 164 LRHPNLTQLYGYFHDEKRVYLLMEYLVNGELYK--HLKGRSHFNDVVASYYVYQMADALD 221 Query: 456 SMHSKGYVHGDVKPENFLLG 515 MH + +H D+KPEN ++G Sbjct: 222 YMHERNILHRDIKPENIIIG 241
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 42.4 bits (98), Expect = 0.001 Identities = 42/165 (25%), Positives = 75/165 (45%), Gaps = 4/165 (2%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF---EHNTSKGCNYGPPYEWHV 269 +Y+ + LGKG FG V + + G+ E AIK +H K E + Sbjct: 68 QYKGIKILGKGSFGEVILSKDKHTGH-------EYAIKVISKKHVKRKTDKQSLLREVEL 120 Query: 270 YSALGGTHGVPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAIS 446 L + + K++ +YY ++ D+ G L+D ++ + A I + +S Sbjct: 121 LKMLDHIN-IMKLYEFFEDNNYYYLVSDVYSGGELFDEI-ISRKRFYEVDAARIIKQVLS 178 Query: 447 ILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 + MH VH D+KPEN LL + ++ + ++D GL+T ++ Sbjct: 179 GITYMHKNNVVHRDLKPENILL-ETKNKEDMIIKIIDFGLSTHFE 222
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 42.4 bits (98), Expect = 0.001 Identities = 43/165 (26%), Positives = 75/165 (45%), Gaps = 4/165 (2%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF---EHNTSKGCNYGPPYEWHV 269 +Y+ + LGKG FG V + R G+ E AIK +H K E + Sbjct: 68 QYKGIKILGKGSFGEVILSRDKHTGH-------EYAIKVISKKHVKRKTDKESLLREVEL 120 Query: 270 YSALGGTHGVPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAIS 446 L + + K++ +YY ++ D+ G L+D ++ + A I + +S Sbjct: 121 LKMLDHIN-IMKLYEFFEDNNYYYLVSDVYTGGELFDEI-ISRKRFYEIDAARIIKQILS 178 Query: 447 ILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 + MH VH D+KPEN LL + ++ + ++D GL+T ++ Sbjct: 179 GITYMHKNNVVHRDLKPENILL-ETKNKEDMIIKIIDFGLSTHFE 222
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 42.4 bits (98), Expect = 0.001 Identities = 42/165 (25%), Positives = 75/165 (45%), Gaps = 4/165 (2%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF---EHNTSKGCNYGPPYEWHV 269 +Y+ + LGKG FG V + + G+ E AIK +H K E + Sbjct: 68 QYKGIKILGKGSFGEVILSKDKHTGH-------EYAIKVISKKHVKRKTDKQSLLREVEL 120 Query: 270 YSALGGTHGVPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAIS 446 L + + K++ +YY ++ D+ G L+D ++ + A I + +S Sbjct: 121 LKMLDHIN-IMKLYEFFEDNNYYYLVSDVYSGGELFDEI-ISRKRFYEVDAARIIKQVLS 178 Query: 447 ILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 + MH VH D+KPEN LL + ++ + ++D GL+T ++ Sbjct: 179 GITYMHKNNVVHRDLKPENILL-ETKNKEDMIIKIIDFGLSTHFE 222
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 42.4 bits (98), Expect = 0.001 Identities = 43/159 (27%), Positives = 75/159 (47%), Gaps = 2/159 (1%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + LG+G FG VF+ R++T + A +V K E + + Sbjct: 61 QFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVR--TKMERDILAD 118 Query: 279 LGGTHGVPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTM-SSEMVACIAAEAISIL 452 + V K+HY + +G Y+++ + G L+ L+ + M + E V AE L Sbjct: 119 VNHPF-VVKLHYAFQTEGKLYLILDFLRGGDLFT--RLSKEVMFTEEDVKFYLAELALGL 175 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 + +HS G ++ D+KPEN LL + G + L D GL+ Sbjct: 176 DHLHSLGIIYRDLKPENILLDEEG-----HIKLTDFGLS 209 Score = 34.3 bits (77), Expect = 0.31 Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 2/80 (2%) Frame = +3 Query: 336 YVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAIS-ILESMHSKGYVHGDVKPENFL- 509 Y++ M G L D + Q SE A IS +E +HS+G VH D+KP N L Sbjct: 475 YLVTELMRGGELLDK--ILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILY 532 Query: 510 LGQPGTPQEKKLFLVDLGLA 569 + + G P+ L + D G A Sbjct: 533 VDESGNPE--CLRICDFGFA 550
>ARBK1_MESAU (Q64682) Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)| (Beta-ARK-1) (G-protein-coupled receptor kinase 2) Length = 689 Score = 42.4 bits (98), Expect = 0.001 Identities = 46/162 (28%), Positives = 72/162 (44%), Gaps = 5/162 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGA-QEVAIKFEHNTSKGCNYGPPYEWHVYS 275 ++ V R +G+GGFG V+ R+ G + IK + + N + Sbjct: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE------RIML 243 Query: 276 ALGGTHGVPKV---HYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +L T P + Y R D I+D++ G L + G ++M + AAE I Sbjct: 244 SLVSTGDCPFIVCMSYAFRTPDNLSFILDLMNGGDLHYHLSQHGVFSEADMRS-YAAEII 302 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 LE MH++ V+ D+KP N LL + G + + DLGLA Sbjct: 303 LGLEHMHNRFVVYRDLKPANILLDEHG-----HVRISDLGLA 339
>PKNA_ANASP (P54734) Serine/threonine-protein kinase pknA (EC 2.7.11.1)| Length = 564 Score = 42.4 bits (98), Expect = 0.001 Identities = 42/159 (26%), Positives = 69/159 (43%), Gaps = 5/159 (3%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPY---EWHVY 272 YRV + LG GGFG F+ + R ++ ++ HN + E + Sbjct: 9 YRVIKTLGSGGFGETFLAEDSQMPSNRRCVVKQ--LRPIHNNPQIYQLVQERFQREAAIL 66 Query: 273 SALGGTHG-VPKVH-YKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAIS 446 LG G +P ++ Y +YV+ + G +L G +S V I + Sbjct: 67 EDLGSYSGQIPTLYAYFQSNTQFYVVQEWVEGDTLTAKLKQQG-VLSESAVRDILINLLP 125 Query: 447 ILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLG 563 +LE +HSK +H D+KP+N +L ++ K L+D G Sbjct: 126 VLEYVHSKRIIHRDIKPDNIILRH----RDGKPVLIDFG 160
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 42.0 bits (97), Expect = 0.001 Identities = 34/142 (23%), Positives = 63/142 (44%), Gaps = 3/142 (2%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + +KLGKG FG V+ R + G E ++N K E + ++ Sbjct: 103 DFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRR----EVEIQTS 158 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAG---QTMSSEMVACIAAEAISI 449 L + Y + Y+++ ++ ++ L G ++S+ + IA + Sbjct: 159 LNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIA----NA 214 Query: 450 LESMHSKGYVHGDVKPENFLLG 515 L+ MH K +H D+KPEN L+G Sbjct: 215 LDYMHKKNIIHRDIKPENILIG 236
>STK16_RAT (P57760) Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein| kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) Length = 304 Score = 42.0 bits (97), Expect = 0.001 Identities = 20/38 (52%), Positives = 25/38 (65%) Frame = +3 Query: 450 LESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLG 563 LE++H+KGY H D+KP N LLG G P L+DLG Sbjct: 135 LEAIHAKGYAHRDLKPTNILLGDEGQP-----VLMDLG 167
>STK16_MOUSE (O88697) Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein| kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct) Length = 304 Score = 42.0 bits (97), Expect = 0.001 Identities = 20/38 (52%), Positives = 25/38 (65%) Frame = +3 Query: 450 LESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLG 563 LE++H+KGY H D+KP N LLG G P L+DLG Sbjct: 135 LEAIHAKGYAHRDLKPTNILLGDEGQP-----VLMDLG 167
>STK16_HUMAN (O75716) Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein| kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK) Length = 304 Score = 42.0 bits (97), Expect = 0.001 Identities = 20/38 (52%), Positives = 25/38 (65%) Frame = +3 Query: 450 LESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLG 563 LE++H+KGY H D+KP N LLG G P L+DLG Sbjct: 135 LEAIHAKGYAHRDLKPTNILLGDEGQP-----VLMDLG 167
>COT1_NEUCR (P38679) Serine/threonine-protein kinase cot-1 (EC 2.7.11.1)| (Colonial temperature-sensitive 1) Length = 598 Score = 42.0 bits (97), Expect = 0.001 Identities = 38/162 (23%), Positives = 72/162 (44%), Gaps = 5/162 (3%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS-- 275 Y+ + +GKG FG V + ++ G A + IK E + HV + Sbjct: 214 YQTIKIIGKGAFGEVKLVQKKADGK---VYAMKSLIKTEM-------FKKDQLAHVRAER 263 Query: 276 ---ALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAIS 446 A + V K++ + ++ M+M+ L + + + S ++ AE + Sbjct: 264 DILAESDSPWVVKLYTTFQDANFLYMLMEFLPGGDLMTMLIKYEIFSEDITRFYIAEIVL 323 Query: 447 ILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 ++++H G++H D+KP+N LL + G + L D GL+T Sbjct: 324 AIDAVHKLGFIHRDIKPDNILLDRGG-----HVKLTDFGLST 360
>CBK1_YARLI (Q6CFS5) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 588 Score = 42.0 bits (97), Expect = 0.001 Identities = 36/157 (22%), Positives = 70/157 (44%), Gaps = 6/157 (3%) Frame = +3 Query: 120 LGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEW-HVYS-----AL 281 +GKG FG V + ++ G A + +K E + + +W HV + A Sbjct: 213 IGKGAFGEVRLVQKRDNGK---IYAMKTMLKKEMDMKE--------QWAHVKAERDVLAD 261 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 + + +++ + Y +IM+ L + + S ++ AE + +E++ Sbjct: 262 SDSPWIVSLYFSFQDDLYLYLIMEFLPGGDLMTMLIKYDVFSEDITRFYIAECVLAIEAI 321 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 H G++H D+KP+N L+ + G + L D GL+T Sbjct: 322 HKLGFIHRDIKPDNILIDKTG-----HIKLSDFGLST 353
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 42.0 bits (97), Expect = 0.001 Identities = 38/143 (26%), Positives = 60/143 (41%), Gaps = 1/143 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y V +G+G FG V+ GRR AQ VA+KF + + + Sbjct: 3 KYHVLEMIGEGSFGRVYKGRRKYS-------AQVVALKFIPKLGRSEKELRNLQREIEIM 55 Query: 279 LGGTH-GVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 G H + + V++ D L G+ + + V IAA+ +S L Sbjct: 56 RGLRHPNIVHMLDSFETDKEVVVVTDYAEGELLQILEDDGK-LPEDQVQAIAAQLVSALY 114 Query: 456 SMHSKGYVHGDVKPENFLLGQPG 524 +HS +H D+KP+N LL + G Sbjct: 115 YLHSHRILHRDMKPQNILLAKGG 137
>PIM1_BRARE (Q9YHZ5) Serine/threonine-protein kinase Pim-1 (EC 2.7.11.1)| Length = 310 Score = 41.6 bits (96), Expect = 0.002 Identities = 45/179 (25%), Positives = 73/179 (40%), Gaps = 17/179 (9%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF-------EHNTSKGCNYGPPY 257 +Y + LG GGFG V+ G R++ G Q+VAIK + + G P Sbjct: 29 QYTMGNLLGSGGFGSVYSGHRISDG-------QKVAIKQISRDRIQQWSKMPGEVNPVPN 81 Query: 258 EWHVYSALGGTHGVPKVH--------YKGRQGDYYVMIMDMLG--PSLWDSWNLAGQTMS 407 E + +LGG G H + G Y+++ + L+D G+ + Sbjct: 82 EIALLQSLGGGSGSVPGHRGIIRMLDWFEIPGQEYLIVFEKPQHCQDLFDFITERGR-LD 140 Query: 408 SEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKD 584 + + I ++ HSKG VH D+K EN L+ + + ++D G KD Sbjct: 141 ESLARRFLKQVIEAVQFCHSKGIVHRDIKDENILV----DTRTGDIKVIDFGSGATLKD 195
>PKNF_MYCTU (P72003) Probable serine/threonine-protein kinase pknF (EC| 2.7.11.1) Length = 476 Score = 41.6 bits (96), Expect = 0.002 Identities = 40/168 (23%), Positives = 69/168 (41%), Gaps = 5/168 (2%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + + R+LG GG G V++ R Q+ + S Y + +A Sbjct: 12 FTIVRQLGSGGMGEVYLARHPR------LPRQDALKVLRADVSADGEYRARFNREADAAA 65 Query: 282 GGTHG-VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISI--- 449 H + VH +G + MD + + D+ +L + M E I+ Sbjct: 66 SLWHPHIVAVHDRGEFDGQLWIDMDFVDGT--DTVSLLRDRYPNGMPGPEVTEIITAVAE 123 Query: 450 -LESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPA 590 L+ H + +H DVKP N L+ P +P ++++ L D G+A DP+ Sbjct: 124 ALDYAHERRLLHRDVKPANILIANPDSP-DRRIMLADFGIAGWVDDPS 170
>PKNF_MYCBO (Q7TZN1) Probable serine/threonine-protein kinase pknF (EC| 2.7.11.1) Length = 476 Score = 41.6 bits (96), Expect = 0.002 Identities = 40/168 (23%), Positives = 69/168 (41%), Gaps = 5/168 (2%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + + R+LG GG G V++ R Q+ + S Y + +A Sbjct: 12 FTIVRQLGSGGMGEVYLARHPR------LPRQDALKVLRADVSADGEYRARFNREADAAA 65 Query: 282 GGTHG-VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISI--- 449 H + VH +G + MD + + D+ +L + M E I+ Sbjct: 66 SLWHPHIVAVHDRGEFDGQLWIDMDFVDGT--DTVSLLRDRYPNGMPGPEVTEIITAVAE 123 Query: 450 -LESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPA 590 L+ H + +H DVKP N L+ P +P ++++ L D G+A DP+ Sbjct: 124 ALDYAHERRLLHRDVKPANILIANPDSP-DRRIMLADFGIAGWVDDPS 170
>PKWA_THECU (P49695) Probable serine/threonine-protein kinase pkwA (EC| 2.7.11.1) Length = 742 Score = 41.6 bits (96), Expect = 0.002 Identities = 37/156 (23%), Positives = 64/156 (41%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 YR+ +LG GG G VF+ R GR + + ++ ++ + E + Sbjct: 16 YRLVSRLGAGGMGQVFLAR---SPGGRPVVVKVILPEYANDDEYRIRFAREVE--AARRV 70 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 GG H + ++ + GPSL + G + + +AA + L ++ Sbjct: 71 GGFHTAQVIDADPTADPPWMATAYIPGPSLRKAVTERGPLYGNNL-RTLAAGLVEGLAAI 129 Query: 462 HSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 H+ G VH D KP N +L G ++D G+A Sbjct: 130 HACGLVHRDFKPSNIVLAADGPR------VIDFGVA 159
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 41.6 bits (96), Expect = 0.002 Identities = 40/176 (22%), Positives = 77/176 (43%), Gaps = 2/176 (1%) Frame = +3 Query: 78 VQIGG--SPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGP 251 +QIG + YR+ +++G+GG +V+ G G+ R + + FE++ + Sbjct: 2 IQIGKIFADRYRIIKEIGRGGMANVYQGEDTFLGD-RLVAIKVLRSNFENDDIAIARF-- 58 Query: 252 PYEWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIA 431 E + L + V + Y+++ + G +L N + E + I Sbjct: 59 QREAFAMAELSHPNIVGISDVGEFESQQYIVMEFVDGMTLKQYINQNAPLANDEAIEIIT 118 Query: 432 AEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 E +S ++ HS G +H D+KP+N L+ GT + + D G+A + + Q Sbjct: 119 -EILSAMDMAHSHGIIHRDLKPQNVLVSSSGTVK-----VTDFGIAKALSETSLTQ 168
>KS6AB_XENLA (P10666) Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1)| (Ribosomal protein S6 kinase II beta) (S6KII-beta) (P90-RSK) Length = 629 Score = 41.6 bits (96), Expect = 0.002 Identities = 43/154 (27%), Positives = 70/154 (45%), Gaps = 4/154 (2%) Frame = +3 Query: 120 LGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSALGGTHG- 296 LG+G FG VF+ R++T + A +V K + L H Sbjct: 68 LGQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERD-----ILADVHHP 122 Query: 297 -VPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTM-SSEMVACIAAEAISILESMHS 467 V ++HY + +G Y+++ + G L+ L+ + M + E V AE L+ +HS Sbjct: 123 FVVRLHYAFQTEGKLYLILDFLRGGDLFT--RLSKEVMFTEEDVKFYLAELALGLDHLHS 180 Query: 468 KGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 G ++ D+KPEN LL + G + L D GL+ Sbjct: 181 LGIIYRDLKPENILLDEEG-----HIKLTDFGLS 209 Score = 33.9 bits (76), Expect = 0.40 Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 2/72 (2%) Frame = +3 Query: 336 YVMIMDMLGPSLWDSWNLAGQTMSSEMVAC-IAAEAISILESMHSKGYVHGDVKPENFL- 509 Y++ M G L D + Q SE AC + +E +HS+G VH D+KP N L Sbjct: 484 YLVTELMRGGELLD--RILRQKFFSEREACSVLFTVCKTVEYLHSQGVVHRDLKPSNILY 541 Query: 510 LGQPGTPQEKKL 545 + + G P+ ++ Sbjct: 542 VDESGDPESIRI 553
>STK38_MOUSE (Q91VJ4) Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1| protein kinase) (Nuclear Dbf2-related kinase 1) Length = 465 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/95 (28%), Positives = 44/95 (46%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGY 476 V K+ Y + +IM+ L + + T++ E AE + ++S+H G+ Sbjct: 149 VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGF 208 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 +H D+KP+N LL G + L D GL T K Sbjct: 209 IHRDIKPDNLLLDSKG-----HVKLSDFGLCTGLK 238
>STK38_HUMAN (Q15208) Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1| protein kinase) (Nuclear Dbf2-related kinase 1) Length = 465 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/95 (28%), Positives = 44/95 (46%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGY 476 V K+ Y + +IM+ L + + T++ E AE + ++S+H G+ Sbjct: 149 VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGF 208 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 +H D+KP+N LL G + L D GL T K Sbjct: 209 IHRDIKPDNLLLDSKG-----HVKLSDFGLCTGLK 238
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 41.6 bits (96), Expect = 0.002 Identities = 43/154 (27%), Positives = 70/154 (45%), Gaps = 4/154 (2%) Frame = +3 Query: 120 LGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSALGGTHG- 296 LG+G FG VF+ R++T + A +V K + L H Sbjct: 68 LGQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERD-----ILADVHHP 122 Query: 297 -VPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTM-SSEMVACIAAEAISILESMHS 467 V ++HY + +G Y+++ + G L+ L+ + M + E V AE L+ +HS Sbjct: 123 FVVRLHYAFQTEGKLYLILDFLRGGDLFT--RLSKEVMFTEEDVKFYLAELALGLDHLHS 180 Query: 468 KGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 G ++ D+KPEN LL + G + L D GL+ Sbjct: 181 LGIIYRDLKPENILLDEEG-----HIKLTDFGLS 209 Score = 33.5 bits (75), Expect = 0.52 Identities = 24/79 (30%), Positives = 38/79 (48%), Gaps = 1/79 (1%) Frame = +3 Query: 336 YVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFL-L 512 YV+ M G L D L + S + + +E++HS+G VH D+KP N L + Sbjct: 484 YVVTELMRGGELLDRI-LRQKFFSEREASSVLFTVCKTVENLHSQGVVHRDLKPSNILYV 542 Query: 513 GQPGTPQEKKLFLVDLGLA 569 + G P+ + + D G A Sbjct: 543 DESGDPE--SIRICDFGFA 559
>STK36_MOUSE (Q69ZM6) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1268 Score = 41.6 bits (96), Expect = 0.002 Identities = 37/143 (25%), Positives = 61/143 (42%), Gaps = 1/143 (0%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +Y V +G+G FG V+ GR+ AQ VA+KF + + + Sbjct: 3 KYHVLEMIGEGSFGRVYKGRKKYS-------AQVVALKFIPKLGRSEKELRNLQREIEIM 55 Query: 279 LGGTH-GVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 G H + + V++ D L+ G+ + + V IAA+ +S L Sbjct: 56 RGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGK-LPEDQVQAIAAQLVSALY 114 Query: 456 SMHSKGYVHGDVKPENFLLGQPG 524 +HS +H D+KP+N LL + G Sbjct: 115 YLHSHRILHRDMKPQNILLAKGG 137
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does| not make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 41.6 bits (96), Expect = 0.002 Identities = 39/141 (27%), Positives = 60/141 (42%), Gaps = 8/141 (5%) Frame = +3 Query: 120 LGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSALGGTHGV 299 +G+GGFG V+ G G QEVA+K +TS E ++ SA+ + V Sbjct: 602 IGEGGFGSVYRGTLDDG--------QEVAVKVRSSTSTQGTREFDNELNLLSAIQHENLV 653 Query: 300 PKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEM--------VACIAAEAISILE 455 P + Y ++ M SL D L G+ ++ +A AA ++ L Sbjct: 654 PLLGYCNEYDQQILVYPFMSNGSLLD--RLYGEASKRKILDWPTRLSIALGAARGLAYLH 711 Query: 456 SMHSKGYVHGDVKPENFLLGQ 518 + + +H DVK N LL Q Sbjct: 712 TFPGRSVIHRDVKSSNILLDQ 732
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 41.6 bits (96), Expect = 0.002 Identities = 43/158 (27%), Positives = 74/158 (46%), Gaps = 2/158 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + + + LG+G FG VF+ R++T + A +V K E + + + Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDNGHLYAMKVLKKATLKVRDRVR--TKMERDILADV 119 Query: 282 GGTHGVPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTM-SSEMVACIAAEAISILE 455 V K+HY + +G Y+++ + G L+ L+ + M + E V AE L+ Sbjct: 120 NHPF-VVKLHYAFQTEGKLYLILDFLRGGDLFT--RLSKEVMFTEEDVKFYLAELALGLD 176 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 +HS G ++ D+KPEN LL + G + L D GL+ Sbjct: 177 HLHSLGIIYRDLKPENILLDEEG-----HIKLTDFGLS 209 Score = 33.5 bits (75), Expect = 0.52 Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 2/80 (2%) Frame = +3 Query: 336 YVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAIS-ILESMHSKGYVHGDVKPENFL- 509 Y++ M G L D + Q SE A IS +E +HS+G VH D+KP N L Sbjct: 486 YLVTELMRGGELLDK--ILRQKFFSEREASFVLYTISKTVEYLHSQGVVHRDLKPSNILY 543 Query: 510 LGQPGTPQEKKLFLVDLGLA 569 + + G P+ L + D G A Sbjct: 544 VDESGNPE--CLRICDFGFA 561
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 41.6 bits (96), Expect = 0.002 Identities = 43/158 (27%), Positives = 74/158 (46%), Gaps = 2/158 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + + + LG+G FG VF+ R++T + A +V K E + + + Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVR--TKMERDILADV 119 Query: 282 GGTHGVPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTM-SSEMVACIAAEAISILE 455 V K+HY + +G Y+++ + G L+ L+ + M + E V AE L+ Sbjct: 120 NHPF-VVKLHYAFQTEGKLYLILDFLRGGDLFT--RLSKEVMFTEEDVKFYLAELALGLD 176 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 +HS G ++ D+KPEN LL + G + L D GL+ Sbjct: 177 HLHSLGIIYRDLKPENILLDEEG-----HIKLTDFGLS 209 Score = 32.7 bits (73), Expect = 0.89 Identities = 27/80 (33%), Positives = 38/80 (47%), Gaps = 2/80 (2%) Frame = +3 Query: 336 YVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAIS-ILESMHSKGYVHGDVKPENFL- 509 Y++ M G L D + Q SE A I +E +HS+G VH D+KP N L Sbjct: 486 YLVTELMRGGELLDK--ILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILY 543 Query: 510 LGQPGTPQEKKLFLVDLGLA 569 + + G P+ L + D G A Sbjct: 544 VDESGNPE--CLRICDFGFA 561
>CDPK3_PLAYO (Q7RAV5) Calcium-dependent protein kinase 3 (EC 2.7.11.1)| Length = 538 Score = 41.2 bits (95), Expect = 0.003 Identities = 31/95 (32%), Positives = 47/95 (49%), Gaps = 2/95 (2%) Frame = +3 Query: 342 MIMDML-GPSLWDSWNLAGQTMSSEMVAC-IAAEAISILESMHSKGYVHGDVKPENFLLG 515 +IMD+ G L+D G + EM A I + S+L +H + H D+KPENFL Sbjct: 184 LIMDLCTGGELFDKIIKKGSFV--EMYASFIMKQIFSVLNYLHIRNICHRDIKPENFLFY 241 Query: 516 QPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQR 620 T E + ++D GLA + D +DY+ + Sbjct: 242 DKST--ESLIKIIDFGLAAYFND------IDYEMK 268
>SPKC_SYNY3 (P74745) Serine/threonine-protein kinase C (EC 2.7.11.1)| Length = 535 Score = 41.2 bits (95), Expect = 0.003 Identities = 33/157 (21%), Positives = 66/157 (42%), Gaps = 2/157 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEH-NTSKGCNYGPPYEWHVYSA 278 YR+ LG+GGFG F+ + + R + + E+ E Sbjct: 12 YRIIETLGRGGFGETFLAQDTHMPSARKCVIKHLKPVLENPEIPSWLRERFHREAATLEE 71 Query: 279 LGGTHG-VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 LG H +P+++ +G+ + ++ + + + SS V + + +LE Sbjct: 72 LGENHPQIPQLYAYFSEGEDFYLVQEWIPGLTLTQAHAQKGNFSSTAVEELLLGILPVLE 131 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGL 566 +H + +H D+KP+N +L + + K L+D G+ Sbjct: 132 FIHQRRIIHRDIKPDNIILRE----ADGKPILIDFGI 164
>GRK1_CAEBR (Q622Z7) G protein-coupled receptor kinase 1 (EC 2.7.11.16)| Length = 640 Score = 41.2 bits (95), Expect = 0.003 Identities = 43/164 (26%), Positives = 71/164 (43%), Gaps = 3/164 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGR-RLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +R+ R LGKGGFG V + R +G ++ +K H + N E + Sbjct: 202 FRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSLN-----EKQILQK 256 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDML--GPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 + V + Y D +++ ++ G + +NL + V AAE L Sbjct: 257 VNSPF-VVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLMPGGFDEKRVQFYAAEITLGL 315 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKD 584 + +H + ++ D+KPEN LL G + + DLGLA + KD Sbjct: 316 QHLHLEHILYRDLKPENILLDDFG-----HVRISDLGLAVELKD 354
>VRK2_MOUSE (Q8BN21) Serine/threonine-protein kinase VRK2 (EC 2.7.11.1)| (Vaccinia-related kinase 2) Length = 503 Score = 41.2 bits (95), Expect = 0.003 Identities = 30/110 (27%), Positives = 47/110 (42%) Frame = +3 Query: 291 HGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSK 470 +G +KGR Y M+M+ LG L + G V + + +LE +H Sbjct: 104 YGFGLTDFKGRS--YRFMVMERLGIDLQKLLDQNGG-FKKLTVLQLGIRMLDVLEYIHEN 160 Query: 471 GYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYDQR 620 YVHGD+K N LL +++L D GL+ ++ + D R Sbjct: 161 EYVHGDIKAANLLL---DFTNPDRVYLADYGLSYRYCPNGNHKQYQEDPR 207
>SID2_SCHPO (Q09898) Serine/threonine-protein kinase sid2 (EC 2.7.11.1)| Length = 607 Score = 41.2 bits (95), Expect = 0.003 Identities = 19/48 (39%), Positives = 29/48 (60%) Frame = +3 Query: 429 AAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 A E ++++H GY+H D+KPENFL+G G + L D GL++ Sbjct: 312 ATEMFLAIDALHQLGYIHRDLKPENFLVGASG-----HIKLTDFGLSS 354
>PK1_ASFB7 (P42493) Serine/threonine-protein kinase (EC 2.7.11.1)| Length = 298 Score = 41.2 bits (95), Expect = 0.003 Identities = 36/164 (21%), Positives = 73/164 (44%) Frame = +3 Query: 114 RKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSALGGTH 293 R + +GG +VF+G ++ Q + K+ P E V AL T Sbjct: 42 RPMFEGGRNNVFLGHQV---------GQPIIFKYVSKKEI-----PGNEVIVLKALQDTP 87 Query: 294 GVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKG 473 GV K+ Y+++I++ + S+ + + I + I I+++++ KG Sbjct: 88 GVIKLIEYTENAMYHILIIEYIPNSVDLLHYHYFKKLEETEAKKIIFQLILIIQNIYEKG 147 Query: 474 YVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHV 605 ++HGD+K EN ++ +K + ++D G A + + Q ++ Sbjct: 148 FIHGDIKDENLII----DINQKIIKVIDFGSAVRLDETRPQYNM 187
>PMYT1_MOUSE (Q9ESG9) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Length = 490 Score = 41.2 bits (95), Expect = 0.003 Identities = 36/142 (25%), Positives = 56/142 (39%), Gaps = 6/142 (4%) Frame = +3 Query: 117 KLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSALGGTHG 296 +LG G +G VF R + +GR + F GP + +GG Sbjct: 106 RLGHGSYGEVFKVR--SKEDGRLYAVKRYMSPFR---------GPKDRTRKLAEVGGHEK 154 Query: 297 VP------KVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILES 458 V ++ +G + ++ GPSL G ++ V + + L+ Sbjct: 155 VGQHPHCVRLERAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDILLALDH 214 Query: 459 MHSKGYVHGDVKPENFLLGQPG 524 +HS+G VH DVKP N LG G Sbjct: 215 LHSQGLVHLDVKPANIFLGPRG 236
>PIT1_SCHPO (O14132) Sporulation protein kinase pit1 (EC 2.7.11.1)| Length = 650 Score = 41.2 bits (95), Expect = 0.003 Identities = 40/165 (24%), Positives = 66/165 (40%), Gaps = 9/165 (5%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIK-FEHNTSKGCNYGPPYEWHVYSA 278 Y V RK+G G FG V++ T + VAIK + +K + E H Sbjct: 36 YNVVRKVGDGTFGSVYLATTKTPSK------EVVAIKSMKKKLAKVSDATRLREVHSLLR 89 Query: 279 LGGTHGVPKVHYKGRQGDYYV-------MIMDMLGPSLWDSWNLA-GQTMSSEMVACIAA 434 L + + D Y+ ++M+ L +L+ + ++ E V I Sbjct: 90 LSENENIVNIF------DLYIDQFRCLHIVMEFLDCNLYQLISTRKNDPLTLEQVQDIMR 143 Query: 435 EAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 + L +H+ G+ H D+KPEN L+ + + D GLA Sbjct: 144 QIFKGLNHIHTNGFFHRDMKPENILISSNSDSSSFNVKIADFGLA 188
>PKNE_MYCBO (Q7TZN3) Serine/threonine-protein kinase pknE (EC 2.7.11.1)| Length = 566 Score = 41.2 bits (95), Expect = 0.003 Identities = 46/169 (27%), Positives = 68/169 (40%), Gaps = 3/169 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNT-SKGCNYGPPYEWHVYSA 278 YR+ R +G+GG G V+ + VA+K T S ++ + +A Sbjct: 16 YRLRRLVGRGGMGDVYEAEDTVR-------ERIVALKLMSETLSSDPDFRTRMQREARTA 68 Query: 279 --LGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 L H VP + G YV + + G L G VA I + S L Sbjct: 69 GRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVA-IVRQIGSAL 127 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 ++ H+ G H DVKPEN L+ + +LVD G+A+ D Q Sbjct: 128 DAAHAAGATHRDVKPENILVS-----ADDFAYLVDFGIASATTDEKLTQ 171
>SPKF_SYNY3 (P73469) Serine/threonine-protein kinase F (EC 2.7.11.1)| Length = 495 Score = 41.2 bits (95), Expect = 0.003 Identities = 24/83 (28%), Positives = 41/83 (49%), Gaps = 1/83 (1%) Frame = +3 Query: 318 GRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVK 494 G+Q ++ ++ + + G L + G +E V + E + IL +H G +H D+K Sbjct: 131 GKQDQFFYLVQEFINGQDLEKTVEKHGPLSEAE-VRWVLTEMLKILSFVHGTGAIHRDIK 189 Query: 495 PENFLLGQPGTPQEKKLFLVDLG 563 P N + Q G KL+L+D G Sbjct: 190 PSNLMRDQEG-----KLYLLDFG 207
>BUB1_HUMAN (O43683) Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC| 2.7.11.1) (hBUB1) (BUB1A) Length = 1085 Score = 41.2 bits (95), Expect = 0.003 Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 6/72 (8%) Frame = +3 Query: 384 NLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKK------L 545 N + M +V A + ++E +H +HGD+KP+NF+LG Q+ + L Sbjct: 883 NTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGL 942 Query: 546 FLVDLGLATKWK 581 L+DLG + K Sbjct: 943 ALIDLGQSIDMK 954
>LATS1_HUMAN (O95835) Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large| tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) Length = 1130 Score = 40.8 bits (94), Expect = 0.003 Identities = 24/95 (25%), Positives = 43/95 (45%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGY 476 V +++Y + D +MD + S + + AE +ES+H G+ Sbjct: 765 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGF 824 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 +H D+KP+N L+ + G + L D GL T ++ Sbjct: 825 IHRDIKPDNILIDRDG-----HIKLTDFGLCTGFR 854
>KAPCG_HUMAN (P22612) cAMP-dependent protein kinase, gamma-catalytic subunit (EC| 2.7.11.11) (PKA C-gamma) Length = 350 Score = 40.8 bits (94), Expect = 0.003 Identities = 44/165 (26%), Positives = 73/165 (44%), Gaps = 2/165 (1%) Frame = +3 Query: 93 SPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVY 272 S ++ R LG G FG V + R G G A ++ K + K + E + Sbjct: 40 SDQFERLRTLGMGSFGRVMLVRHQETG---GHYAMKILNKQKVVKMKQVEH-ILNEKRIL 95 Query: 273 SALGGTHGVPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACI-AAEAIS 446 A+ V K+ + + Y ++M+ + G ++ G+ SE AC AA+ + Sbjct: 96 QAIDFPFLV-KLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRF--SEPHACFYAAQVVL 152 Query: 447 ILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 ++ +HS +H D+KPEN L+ Q G Q + D G A + K Sbjct: 153 AVQYLHSLDLIHRDLKPENLLIDQQGYLQ-----VTDFGFAKRVK 192
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 40.8 bits (94), Expect = 0.003 Identities = 41/159 (25%), Positives = 73/159 (45%), Gaps = 2/159 (1%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVG-RRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 +Y ++ KLG+G +G V+ G ++T Q AIK E + N ++ Sbjct: 70 KYIIDEKLGQGTYGCVYKGIDKVTN--------QLYAIK-EEKKDRLKNINRFFQEIEIM 120 Query: 276 ALGGTHGVPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 + K++ +Y +IM++ G L+DS + + + + A I + S + Sbjct: 121 KKLDHPNIVKLYETYENDNYIYLIMELCSGRELFDSI-IENGSFTEKNAATIMKQIFSAI 179 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 +HS VH D+KPENFL ++ L ++D GL+ Sbjct: 180 FYLHSLNIVHRDLKPENFLFQSEN--KDSLLKIIDFGLS 216
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 40.8 bits (94), Expect = 0.003 Identities = 35/162 (21%), Positives = 66/162 (40%), Gaps = 2/162 (1%) Frame = +3 Query: 93 SPEYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF-EHNTSKGCNYGPPYEWHV 269 S Y++ R +G GG +V++ + +EVAIK + + + + Sbjct: 8 SGRYQILRVIGGGGMANVYLAEDIILD-------REVAIKILRFDYANDNEFIRRFRREA 60 Query: 270 YSALGGTH-GVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAIS 446 SA H + ++ G + D Y ++M+ + + A + + I + +S Sbjct: 61 QSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITANGPLHPKEALNIMEQIVS 120 Query: 447 ILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 + H VH D+KP N L+ G + + D G+AT Sbjct: 121 AIAHAHQNQIVHRDIKPHNILIDHMG-----NIKVTDFGIAT 157
>MKNK2_RAT (Q5U2N4) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 459 Score = 40.8 bits (94), Expect = 0.003 Identities = 26/104 (25%), Positives = 49/104 (47%), Gaps = 1/104 (0%) Frame = +3 Query: 267 VYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI- 443 +Y G + + + + + +Y++ M G S+ ++ + +E+ A + + + Sbjct: 133 LYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILS--HIHRRRHFNELEASVVVQDVA 190 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 S L+ +H+KG H D+KPEN L P K+ DLG K Sbjct: 191 SALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIK 234
>MKNK2_MOUSE (Q8CDB0) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 459 Score = 40.8 bits (94), Expect = 0.003 Identities = 26/104 (25%), Positives = 49/104 (47%), Gaps = 1/104 (0%) Frame = +3 Query: 267 VYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI- 443 +Y G + + + + + +Y++ M G S+ ++ + +E+ A + + + Sbjct: 133 LYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILS--HIHRRRHFNELEASVVVQDVA 190 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 S L+ +H+KG H D+KPEN L P K+ DLG K Sbjct: 191 SALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIK 234
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1)| (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 40.8 bits (94), Expect = 0.003 Identities = 42/164 (25%), Positives = 75/164 (45%), Gaps = 2/164 (1%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 ++ + + LG+G FG VF+ R+ TG + A +V K E + Sbjct: 72 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVR--TKMERDILVE 129 Query: 279 LGGTHGVPKVHYKGR-QGDYYVMIMDMLGPSLWDSWNLAGQTM-SSEMVACIAAEAISIL 452 + + K+HY + +G Y+++ + G ++ L+ + + + E V AE L Sbjct: 130 VNHPF-IVKLHYAFQTEGKLYLILDFLRGGDVFT--RLSKEVLFTEEDVKFYLAELALAL 186 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKD 584 + +H G V+ D+KPEN LL + G + L D GL+ + D Sbjct: 187 DHLHQLGIVYRDLKPENILLDEIG-----HIKLTDFGLSKESVD 225
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 40.8 bits (94), Expect = 0.003 Identities = 41/159 (25%), Positives = 73/159 (45%), Gaps = 2/159 (1%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVG-RRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 +Y ++ KLG+G +G V+ G ++T Q AIK E + N ++ Sbjct: 70 KYIIDEKLGQGTYGCVYKGIDKVTN--------QLYAIK-EEKKDRLKNINRFFQEIEIM 120 Query: 276 ALGGTHGVPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 + K++ +Y +IM++ G L+DS + + + + A I + S + Sbjct: 121 KKLDHPNIVKLYETYENDNYIYLIMELCSGRELFDSI-IENGSFTEKNAATIMKQIFSAI 179 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 +HS VH D+KPENFL ++ L ++D GL+ Sbjct: 180 FYLHSLNIVHRDLKPENFLFQSEN--KDSLLKIIDFGLS 216
>BUR1_YARLI (Q6C842) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 706 Score = 40.8 bits (94), Expect = 0.003 Identities = 40/172 (23%), Positives = 67/172 (38%), Gaps = 9/172 (5%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIK--FEHNTSKGCNYGPPYEWHVYS 275 Y+ K+G+G FG VF ++T + VA+K H+ +G E + Sbjct: 38 YKPLGKIGEGTFGEVFRAEQITT-------KRHVALKKILLHSEKEGFPVTALREIRILK 90 Query: 276 ALGGTHGVPKVHYKGRQGDY-------YVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAA 434 L + +P V +GD M+ + L +S + C Sbjct: 91 LLRHENVIPLVDLAVERGDQSKKERGCVYMVTPYMDHDLAGLLGNQSVQLSPAHIKCYML 150 Query: 435 EAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPA 590 + + + +H+K ++H D+K N L+ G L L D GLA + PA Sbjct: 151 QLLEGIGYLHAKKFLHRDIKAANILVNDQGI-----LKLADFGLARGYDGPA 197
>CDPK_DAUCA (P28582) Calcium-dependent protein kinase (EC 2.7.11.1) (CDPK)| Length = 532 Score = 40.8 bits (94), Expect = 0.003 Identities = 48/177 (27%), Positives = 73/177 (41%), Gaps = 10/177 (5%) Frame = +3 Query: 69 PDTVQIGGSP------EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTS 230 P++ I G P +Y + ++LG+G FG V+ N G +I S Sbjct: 64 PESNTILGKPFEDIRGKYTLGKELGRGQFGCVYQCTE----NSSGQLYACKSILKRKLVS 119 Query: 231 KGCNYGPPYEWHVYSALGGTHGVPKVHYKG----RQGDYYVMIMDMLGPSLWDSWNLAGQ 398 K E + L G + V +KG RQ + VM + G L+D G Sbjct: 120 KNDKEDIKREIQILQHLSGQPNI--VEFKGVFEDRQSVHLVMEL-CAGGELFDRIIAQGH 176 Query: 399 TMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 S A I + ++++ H G +H D+KPENFLL ++ L D GL+ Sbjct: 177 -YSERAAATICRQIVNVVHVCHFMGVMHRDLKPENFLLS--SKDKDAMLKATDFGLS 230
>KDC2_DROME (P16912) Protein kinase DC2 (EC 2.7.11.1)| Length = 583 Score = 40.8 bits (94), Expect = 0.003 Identities = 30/82 (36%), Positives = 43/82 (52%), Gaps = 1/82 (1%) Frame = +3 Query: 342 MIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQ 518 MI D + G L+ AG+ +S+ AAE +S LE +HS V+ D+KPEN L+ + Sbjct: 349 MIFDYVCGGELFTYLRNAGK-FTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINR 407 Query: 519 PGTPQEKKLFLVDLGLATKWKD 584 G L + D G A K +D Sbjct: 408 DG-----HLKITDFGFAKKLRD 424
>RAN1_SCHPO (P08092) Negative regulator of sexual conjugation and meiosis (EC| 2.7.11.1) Length = 470 Score = 40.8 bits (94), Expect = 0.003 Identities = 20/56 (35%), Positives = 31/56 (55%) Frame = +3 Query: 405 SSEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 +S ++ + + IS +E HS G H D+KPEN ++G ++L D GLAT Sbjct: 116 NSHLIKTVFLQLISAVEHCHSVGIYHRDLKPENIMVGN----DVNTVYLADFGLAT 167
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 40.8 bits (94), Expect = 0.003 Identities = 41/163 (25%), Positives = 69/163 (42%), Gaps = 2/163 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF--EHNTSKGCNYGPPYEWHVYS 275 Y++ + LG+G FG V + + L G Q+VA+K +K G Y Sbjct: 53 YQILKTLGEGSFGKVKLAQHLGTG-------QKVALKIINRKTLAKSDMQGRVEREISYL 105 Query: 276 ALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 L + K++ + D +M+++ G L+D G+ M + + I+ +E Sbjct: 106 RLLRHPHIIKLYDVIKSKDEIIMVIEFAGKELFDYIVQRGK-MPEDEARRFFQQIIAAVE 164 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKD 584 H VH D+KPEN LL + + + D GL+ D Sbjct: 165 YCHRHKIVHRDLKPENLLL-----DDQLNVKIADFGLSNIMTD 202
>LATS1_MOUSE (Q8BYR2) Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large| tumor suppressor homolog 1) (WARTS protein kinase) Length = 1129 Score = 40.8 bits (94), Expect = 0.003 Identities = 24/95 (25%), Positives = 43/95 (45%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGY 476 V +++Y + D +MD + S + + AE +ES+H G+ Sbjct: 764 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGF 823 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 +H D+KP+N L+ + G + L D GL T ++ Sbjct: 824 IHRDIKPDNILIDRDG-----HIKLTDFGLCTGFR 853
>GRK2_CAEEL (Q09639) G protein-coupled receptor kinase 2 (EC 2.7.11.16)| Length = 707 Score = 40.8 bits (94), Expect = 0.003 Identities = 45/162 (27%), Positives = 71/162 (43%), Gaps = 5/162 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGA-QEVAIKFEHNTSKGCNYGPPYEWHVYS 275 ++ V R +G+GGFG V+ R+ G + IK + + N E + S Sbjct: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN-----ERIMLS 244 Query: 276 ALGGTHGVPKV---HYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAI 443 + P + Y + D I+D++ G L + G EM+ A+E I Sbjct: 245 LVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNGGDLHYHLSQHGVFTEQEMIF-YASEVI 303 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 LE MH++ V+ D+KP N LL + G + + DLGLA Sbjct: 304 LGLEHMHNRFVVYRDLKPANILLDENG-----HVRVSDLGLA 340
>MKNK2_HUMAN (Q9HBH9) MAP kinase-interacting serine/threonine-protein kinase 2| (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 465 Score = 40.8 bits (94), Expect = 0.003 Identities = 26/104 (25%), Positives = 49/104 (47%), Gaps = 1/104 (0%) Frame = +3 Query: 267 VYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI- 443 +Y G + + + + + +Y++ M G S+ ++ + +E+ A + + + Sbjct: 133 LYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILS--HIHKRRHFNELEASVVVQDVA 190 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 S L+ +H+KG H D+KPEN L P K+ DLG K Sbjct: 191 SALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIK 234
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 40.8 bits (94), Expect = 0.003 Identities = 36/141 (25%), Positives = 60/141 (42%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 + + R LGKG FG+V++ R R A ++ K + +G + E + + L Sbjct: 82 FEIGRPLGKGKFGNVYLAREK---KSRFIVALKILFKSQIE-KEGVEHQLRREIEIQAHL 137 Query: 282 GGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESM 461 + + +Y Q Y+++ L+ + +T + A I E L Sbjct: 138 KHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKS-RTFDEQRTATIMEELSDALTYC 196 Query: 462 HSKGYVHGDVKPENFLLGQPG 524 H K +H D+KPEN LLG G Sbjct: 197 HKKKVIHRDIKPENLLLGLQG 217
>GRK4_HUMAN (P32298) G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK4) (ITI1) Length = 578 Score = 40.4 bits (93), Expect = 0.004 Identities = 46/161 (28%), Positives = 66/161 (40%), Gaps = 3/161 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGR-RLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +R R LGKGGFG V + R TG Q+ IK + N E V S Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE-KVQSR 245 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDML--GPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 V + Y D +++ ++ G + +NL + AAE L Sbjct: 246 F-----VVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 E + + V+ D+KPEN LL G + + DLGLAT+ Sbjct: 301 EDLQRERIVYRDLKPENILLDDRG-----HIRISDLGLATE 336
>CSK2A_DICDI (Q02720) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II alpha| subunit) Length = 337 Score = 40.4 bits (93), Expect = 0.004 Identities = 23/63 (36%), Positives = 35/63 (55%) Frame = +3 Query: 435 EAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHVDYD 614 E + L+ HS G +H DVKP N ++ Q++KL+L+D GLA ++ P +V Sbjct: 147 ELLHALDFCHSNGIMHRDVKPSNVMIDH----QKRKLYLIDWGLA-EFYHPNQDYNVRVA 201 Query: 615 QRP 623 RP Sbjct: 202 SRP 204
>ICK_HUMAN (Q9UPZ9) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2) Length = 632 Score = 40.4 bits (93), Expect = 0.004 Identities = 37/164 (22%), Positives = 63/164 (38%), Gaps = 8/164 (4%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 Y R+LG G +G V +GR + G + +AIK Y W L Sbjct: 4 YTTIRQLGDGTYGSVLLGRSIESG-------ELIAIKKMKRKF--------YSWEECMNL 48 Query: 282 GGTHGVPKVHYKG--------RQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAE 437 + K+++ R+ D+ I + + +L+ + + I + Sbjct: 49 REVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQ 108 Query: 438 AISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 + L +H G+ H D+KPEN L P + + + D GLA Sbjct: 109 ILQGLAFIHKHGFFHRDLKPENLLCMGP-----ELVKIADFGLA 147
>SID1_SCHPO (O14305) Serine/threonine-protein kinase sid1 (EC 2.7.11.1)| (STE20-like kinase sid1) Length = 471 Score = 40.4 bits (93), Expect = 0.004 Identities = 43/170 (25%), Positives = 76/170 (44%), Gaps = 3/170 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 Y + RKLG G FG V+ R G+ +AIK + + G + E V+ L Sbjct: 9 YTLLRKLGSGSFGVVWKARENVSGD-------IIAIK-QIDLETGIDDITDIEQEVF-ML 59 Query: 282 GGTHGVPKVHYKGRQGDYY---VMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 + + Y G D Y +++ M G S+ S L ++ ++++ I E + L Sbjct: 60 SNCNSSNVIQYYGCFVDGYTLWILMEHMDGGSV--SGLLKMGRLNEQVISIILREVLYGL 117 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQH 602 +H + +H D+K N LL + + L D G+A + + A+++H Sbjct: 118 NYLHGQNKIHRDIKAANILL----SSSTGNVKLADFGVAAQLSNAASRRH 163
>PK1_ASFM2 (P34206) Serine/threonine-protein kinase (EC 2.7.11.1)| Length = 299 Score = 40.4 bits (93), Expect = 0.004 Identities = 28/119 (23%), Positives = 57/119 (47%) Frame = +3 Query: 249 PPYEWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACI 428 P E V AL T GV K+ Y+++I++ + S+ + + I Sbjct: 74 PGNEVVVMKALQDTPGVIKLIEYTENAMYHILIIEYIPNSIDLLHYHYFKKLEENEAKKI 133 Query: 429 AAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHV 605 + I I+++++ KG++HGD+K EN ++ +K + ++D G A + + Q ++ Sbjct: 134 IFQMILIIQNIYEKGFIHGDIKDENLII----DIDQKIIKVIDFGSAVRLNETHPQYNM 188
>KPK1_ARATH (P42818) Serine/threonine-protein kinase AtPK1/AtPK6 (EC 2.7.11.1)| Length = 465 Score = 40.4 bits (93), Expect = 0.004 Identities = 19/58 (32%), Positives = 32/58 (55%) Frame = +3 Query: 411 EMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKD 584 ++ AE +S + +H KG +H D+KPEN L+ G + L D GLA ++++ Sbjct: 232 DLARVYTAEIVSAVSHLHEKGIMHRDLKPENILMDTDG-----HVMLTDFGLAKEFEE 284
>PKH3_YEAST (Q03306) Serine/threonine-protein kinase PKH3 (EC 2.7.11.1)| (Pkb-activating kinase homolog 3) Length = 898 Score = 40.4 bits (93), Expect = 0.004 Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 1/93 (1%) Frame = +3 Query: 294 GVPKVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSK 470 G+ K++Y + ++D G L + G T + A+ I LE +HS Sbjct: 74 GIIKLYYTFHDEENLYFVLDFAPGGELLSLLHKMG-TFNDIWTRHFTAQLIDALEFIHSH 132 Query: 471 GYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 G +H D+KPEN LL + G +L + D G A Sbjct: 133 GIIHRDLKPENVLLDRDG-----RLMITDFGAA 160
>BRSK1_HUMAN (Q8TDC3) BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1| kinase) (SAD1A) Length = 794 Score = 40.4 bits (93), Expect = 0.004 Identities = 44/160 (27%), Positives = 68/160 (42%), Gaps = 3/160 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF--EHNTSKGCNYGPPYEWHVYS 275 YR+E+ LGKG G V +G G Q+VAIK S+ E + Sbjct: 50 YRLEKTLGKGQTGLVKLGVHCITG-------QKVAIKIVNREKLSESVLMKVEREIAILK 102 Query: 276 ALGGTHGVPKVHYKGRQGDY-YVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 + H V K+H Y Y+++ + G L+D G+ E + +S L Sbjct: 103 LIEHPH-VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKE-ARKFFRQIVSAL 160 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLAT 572 + HS H D+KPEN LL ++ + + D G+A+ Sbjct: 161 DFCHSYSICHRDLKPENLLL-----DEKNNIRIADFGMAS 195
>PKNE_MYCTU (P72001) Serine/threonine-protein kinase pknE (EC 2.7.11.1)| Length = 566 Score = 40.4 bits (93), Expect = 0.004 Identities = 46/172 (26%), Positives = 65/172 (37%), Gaps = 6/172 (3%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPY------EW 263 YR+ R +G+GG G V+ + VA+K T P + E Sbjct: 16 YRLRRLVGRGGMGDVYEAEDTVR-------ERIVALKLMSETLSS---DPVFRTRMQREA 65 Query: 264 HVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAI 443 L H VP + G YV + + G L G VA I + Sbjct: 66 RTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVA-IVRQIG 124 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 S L++ H+ G H DVKPEN L+ + +LVD G+A+ D Q Sbjct: 125 SALDAAHAAGATHRDVKPENILVS-----ADDFAYLVDFGIASATTDEKLTQ 171
>ARBK1_RAT (P26817) Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)| (Beta-ARK-1) (G-protein-coupled receptor kinase 2) Length = 689 Score = 40.0 bits (92), Expect = 0.006 Identities = 45/162 (27%), Positives = 70/162 (43%), Gaps = 5/162 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGA-QEVAIKFEHNTSKGCNYGPPYEWHVYS 275 ++ V R +G+GGFG V+ R+ G + IK + + N + Sbjct: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE------RIML 243 Query: 276 ALGGTHGVPKV---HYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +L T P + Y D I+D++ G L + G ++M AAE I Sbjct: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADM-RFYAAEII 302 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 LE MH++ V+ D+KP N LL + G + + DLGLA Sbjct: 303 LGLEHMHNRFVVYRDLKPANILLDEHG-----HVRISDLGLA 339
>ARBK1_MOUSE (Q99MK8) Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)| (Beta-ARK-1) (G-protein-coupled receptor kinase 2) Length = 689 Score = 40.0 bits (92), Expect = 0.006 Identities = 45/162 (27%), Positives = 70/162 (43%), Gaps = 5/162 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGA-QEVAIKFEHNTSKGCNYGPPYEWHVYS 275 ++ V R +G+GGFG V+ R+ G + IK + + N + Sbjct: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE------RIML 243 Query: 276 ALGGTHGVPKV---HYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +L T P + Y D I+D++ G L + G ++M AAE I Sbjct: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADM-RFYAAEII 302 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 LE MH++ V+ D+KP N LL + G + + DLGLA Sbjct: 303 LGLEHMHNRFVVYRDLKPANILLDEHG-----HVRISDLGLA 339
>ARBK1_HUMAN (P25098) Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)| (Beta-ARK-1) (G-protein coupled receptor kinase 2) Length = 689 Score = 40.0 bits (92), Expect = 0.006 Identities = 47/162 (29%), Positives = 71/162 (43%), Gaps = 5/162 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGR-RLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYS 275 ++ V R +G+GGFG V+ R R TG + IK + + N + Sbjct: 190 DFSVHRIIGRGGFGEVYGCRKRDTGKMYAMKCLDKKRIKMKQGETLALNE------RIML 243 Query: 276 ALGGTHGVPKV---HYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +L T P + Y D I+D++ G L + G ++M AAE I Sbjct: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADM-RFYAAEII 302 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 LE MH++ V+ D+KP N LL + G + + DLGLA Sbjct: 303 LGLEHMHNRFVVYRDLKPANILLDEHG-----HVRISDLGLA 339
>ARBK1_BOVIN (P21146) Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)| (Beta-ARK-1) (G-protein-coupled receptor kinase 2) Length = 689 Score = 40.0 bits (92), Expect = 0.006 Identities = 45/162 (27%), Positives = 70/162 (43%), Gaps = 5/162 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGA-QEVAIKFEHNTSKGCNYGPPYEWHVYS 275 ++ V R +G+GGFG V+ R+ G + IK + + N + Sbjct: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE------RIML 243 Query: 276 ALGGTHGVPKV---HYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAI 443 +L T P + Y D I+D++ G L + G ++M AAE I Sbjct: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADM-RFYAAEII 302 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 LE MH++ V+ D+KP N LL + G + + DLGLA Sbjct: 303 LGLEHMHNRFVVYRDLKPANILLDEHG-----HVRISDLGLA 339
>YOO1_CAEEL (P34633) Putative serine/threonine-protein kinase ZK507.1 (EC| 2.7.11.1) Length = 331 Score = 40.0 bits (92), Expect = 0.006 Identities = 20/86 (23%), Positives = 43/86 (50%), Gaps = 1/86 (1%) Frame = +3 Query: 342 MIMDMLGPSLWD-SWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQ 518 ++M ++GPSL + + + + + + H G++H D+KP N+ +G Sbjct: 67 IVMTIVGPSLEELKMKYKPSDIPPSTILQCGLQTMKAIHDFHQIGFLHRDIKPANYCIGY 126 Query: 519 PGTPQEKKLFLVDLGLATKWKDPATQ 596 + + ++++D GLA K++ P Q Sbjct: 127 GS--KSETIYVLDFGLARKYRLPNGQ 150
>GPRK2_DROME (P32866) G protein-coupled receptor kinase 2 (EC 2.7.11.16)| Length = 714 Score = 40.0 bits (92), Expect = 0.006 Identities = 44/162 (27%), Positives = 68/162 (41%), Gaps = 4/162 (2%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGR-RLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSA 278 +R+ R LGKGGFG V + R TG ++ IK S E + Sbjct: 309 FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVL-----IEKQILQK 363 Query: 279 LGGTHGVPKVHYKGRQGDYYVMIMDML--GPSLWDSWNLAGQT-MSSEMVACIAAEAISI 449 + V + Y D +++ ++ G + +N+ G+ E AAE Sbjct: 364 INSPF-VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACG 422 Query: 450 LESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATK 575 L+ +H +G V+ D KPEN LL G + + DLGLA + Sbjct: 423 LQHLHKQGIVYRDCKPENILLDDHG-----HVRISDLGLAVE 459
>PRKX_MOUSE (Q922R0) Serine/threonine-protein kinase PRKX (EC 2.7.11.1)| (PKA-related protein kinase) Length = 355 Score = 40.0 bits (92), Expect = 0.006 Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 1/95 (1%) Frame = +3 Query: 303 KVHYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYV 479 K+ + G + M+M+ + G L+ G+ SS A E + +E +HSK V Sbjct: 108 KLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGR-FSSVASVFYATEIVCAIEYLHSKEIV 166 Query: 480 HGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKD 584 + D+KPEN LL + G + L D G A K D Sbjct: 167 YRDLKPENILLDREG-----HIKLTDFGFAKKLVD 196
>PAK1_MOUSE (O88643) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) Length = 545 Score = 40.0 bits (92), Expect = 0.006 Identities = 23/68 (33%), Positives = 35/68 (51%), Gaps = 1/68 (1%) Frame = +3 Query: 327 GDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPEN 503 GD ++M+ L G SL D + M +A + E + LE +HS +H D+K +N Sbjct: 337 GDELWVVMEYLAGGSLTDV--VTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDN 394 Query: 504 FLLGQPGT 527 LLG G+ Sbjct: 395 ILLGMDGS 402
>PAK1_HUMAN (Q13153) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 40.0 bits (92), Expect = 0.006 Identities = 23/68 (33%), Positives = 35/68 (51%), Gaps = 1/68 (1%) Frame = +3 Query: 327 GDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPEN 503 GD ++M+ L G SL D + M +A + E + LE +HS +H D+K +N Sbjct: 337 GDELWVVMEYLAGGSLTDV--VTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDN 394 Query: 504 FLLGQPGT 527 LLG G+ Sbjct: 395 ILLGMDGS 402
>CSK2A_NEUCR (Q8TG13) Casein kinase II subunit alpha (EC 2.7.11.1) (CK II alpha| subunit) Length = 336 Score = 40.0 bits (92), Expect = 0.006 Identities = 22/57 (38%), Positives = 34/57 (59%) Frame = +3 Query: 435 EAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHV 605 E + L+ HSKG +H DVKP N ++ + +KL L+D GLA ++ P T+ +V Sbjct: 132 ELLKALDFCHSKGIMHRDVKPHNVMIDH----ENRKLRLIDWGLA-EFYHPGTEYNV 183
>PAK1_RAT (P35465) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) Length = 544 Score = 40.0 bits (92), Expect = 0.006 Identities = 23/68 (33%), Positives = 35/68 (51%), Gaps = 1/68 (1%) Frame = +3 Query: 327 GDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPEN 503 GD ++M+ L G SL D + M +A + E + LE +HS +H D+K +N Sbjct: 336 GDELWVVMEYLAGGSLTDV--VTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDN 393 Query: 504 FLLGQPGT 527 LLG G+ Sbjct: 394 ILLGMDGS 401
>KPK19_ARATH (Q39030) Serine/threonine-protein kinase AtPK19 (EC 2.7.11.1)| (Ribosomal-protein S6 kinase homolog) Length = 471 Score = 40.0 bits (92), Expect = 0.006 Identities = 19/58 (32%), Positives = 32/58 (55%) Frame = +3 Query: 411 EMVACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKD 584 ++ AE +S + +H KG +H D+KPEN L+ G + L D GLA ++++ Sbjct: 238 DLARVYTAEIVSAVSHLHEKGIMHRDLKPENILMDVDG-----HVMLTDFGLAKEFEE 290
>ST38L_MOUSE (Q7TSE6) Serine/threonine-protein kinase 38-like (EC 2.7.11.1)| (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) Length = 464 Score = 40.0 bits (92), Expect = 0.006 Identities = 26/95 (27%), Positives = 44/95 (46%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGY 476 V K+ Y + +IM+ L + + T++ E +E + ++++H G+ Sbjct: 150 VVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGF 209 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 +H DVKP+N LL G + L D GL T K Sbjct: 210 IHRDVKPDNLLLDAKG-----HVKLSDFGLCTGLK 239
>CDPK2_ORYSA (P53683) Calcium-dependent protein kinase, isoform 2 (EC 2.7.11.1)| (CDPK 2) Length = 533 Score = 40.0 bits (92), Expect = 0.006 Identities = 40/160 (25%), Positives = 65/160 (40%), Gaps = 4/160 (2%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 Y + ++LG+G FG ++ + G + I SK E + L Sbjct: 85 YSLGKELGRGQFGVTYLCTEIASGKQYACKS----ISKRKLVSKADKEDIRREIQIMQHL 140 Query: 282 GGTHGVPKVHYKGRQGD---YYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISIL 452 G + V ++G D +V++ G L+D G S A I ++++ Sbjct: 141 SGQQNI--VEFRGAYEDKSNVHVVMELCAGGELFDRIIAKGH-YSERAAATICRAVVNVV 197 Query: 453 ESMHSKGYVHGDVKPENFLLGQPGTPQEKKLF-LVDLGLA 569 H G +H D+KPENFLL T +E + D GL+ Sbjct: 198 NICHFMGVMHRDLKPENFLL---ATKEENAMLKATDFGLS 234
>KAPC_ENCCU (Q8SRK8) Probable cAMP-dependent protein kinase catalytic subunit| (EC 2.7.11.11) Length = 322 Score = 40.0 bits (92), Expect = 0.006 Identities = 28/104 (26%), Positives = 45/104 (43%) Frame = +3 Query: 258 EWHVYSALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAE 437 E + + G V K++ G +IM+ +G W +M AAE Sbjct: 56 EISILKRIYGCPFVAKLYSTDFHGGKVGLIMEYVGGGELFYWLKKCGRFDEQMARFYAAE 115 Query: 438 AISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 IS L +H +G ++ D+KPEN L+ G + L+D G + Sbjct: 116 IISALRFIHGRGILYRDLKPENILITSTG-----HIKLIDFGFS 154
>BUB1_YEAST (P41695) Checkpoint serine/threonine-protein kinase BUB1 (EC| 2.7.11.1) Length = 1021 Score = 40.0 bits (92), Expect = 0.006 Identities = 21/69 (30%), Positives = 34/69 (49%), Gaps = 15/69 (21%) Frame = +3 Query: 402 MSSEMVACIAAEAISILESMHSKGYVHGDVKPENFL--LGQPGTP-------------QE 536 M + I E + +LE +H G +HGD+KP+N + L +PG P + Sbjct: 805 MDEYLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMIRLEKPGEPLGAHYMRNGEDGWEN 864 Query: 537 KKLFLVDLG 563 K ++L+D G Sbjct: 865 KGIYLIDFG 873
>CSK22_CHICK (P21869) Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II)| Length = 350 Score = 40.0 bits (92), Expect = 0.006 Identities = 23/57 (40%), Positives = 34/57 (59%) Frame = +3 Query: 435 EAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQHV 605 E + L+ HS G +H DVKP N ++ Q+KKL L+D GLA ++ PA + +V Sbjct: 140 ELLKALDYCHSMGIMHRDVKPHNVMIDH----QQKKLRLIDWGLA-EFYHPAQEYNV 191
>ST38L_HUMAN (Q9Y2H1) Serine/threonine-protein kinase 38-like (EC 2.7.11.1)| (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) Length = 464 Score = 39.7 bits (91), Expect = 0.007 Identities = 25/95 (26%), Positives = 44/95 (46%) Frame = +3 Query: 297 VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGY 476 V K+ Y + +IM+ L + + T++ E +E + ++++H G+ Sbjct: 150 VVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGF 209 Query: 477 VHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWK 581 +H D+KP+N LL G + L D GL T K Sbjct: 210 IHRDIKPDNLLLDAKG-----HVKLSDFGLCTGLK 239
>PMYT1_HUMAN (Q99640) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Length = 499 Score = 39.7 bits (91), Expect = 0.007 Identities = 26/83 (31%), Positives = 38/83 (45%), Gaps = 1/83 (1%) Frame = +3 Query: 324 QGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPEN 503 +G + ++ GPSL G ++ V + + L +HS+G VH DVKP N Sbjct: 179 EGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPAN 238 Query: 504 FLLGQPGTPQEKKL-FLVDLGLA 569 LG G + LV+LG A Sbjct: 239 IFLGPRGRCKLGDFGLLVELGTA 261
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 39.7 bits (91), Expect = 0.007 Identities = 40/163 (24%), Positives = 69/163 (42%), Gaps = 2/163 (1%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKF--EHNTSKGCNYGPPYEWHVYS 275 Y++ + LG+G FG V + + + G Q+VA+K +K G Y Sbjct: 52 YQIIKTLGEGSFGKVKLAQHVGTG-------QKVALKIINRKTLAKSDMQGRVEREISYL 104 Query: 276 ALGGTHGVPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILE 455 L + K++ + D +M+++ G L+D G+ M + + I+ +E Sbjct: 105 RLLRHPHIIKLYDVIKSKDEIIMVIEFAGKELFDYIVQRGK-MPEDEARRFFQQIIAAVE 163 Query: 456 SMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKD 584 H VH D+KPEN LL + + + D GL+ D Sbjct: 164 YCHRHKIVHRDLKPENLLL-----DDQLNVKIADFGLSNIMTD 201
>PAK2_RAT (Q64303) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p62-PAK) Length = 524 Score = 39.7 bits (91), Expect = 0.007 Identities = 22/68 (32%), Positives = 35/68 (51%), Gaps = 1/68 (1%) Frame = +3 Query: 327 GDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPEN 503 GD ++M+ L G SL D + M +A + E + LE +H+ +H D+K +N Sbjct: 316 GDELFVVMEYLAGGSLTDV--VTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDN 373 Query: 504 FLLGQPGT 527 LLG G+ Sbjct: 374 VLLGMEGS 381
>PAK2_RABIT (Q29502) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p21-activated protein kinase I) (PAKI) Length = 524 Score = 39.7 bits (91), Expect = 0.007 Identities = 22/68 (32%), Positives = 35/68 (51%), Gaps = 1/68 (1%) Frame = +3 Query: 327 GDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPEN 503 GD ++M+ L G SL D + M +A + E + LE +H+ +H D+K +N Sbjct: 316 GDELFVVMEYLAGGSLTDV--VTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDN 373 Query: 504 FLLGQPGT 527 LLG G+ Sbjct: 374 VLLGMEGS 381
>PAK2_MOUSE (Q8CIN4) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) Length = 524 Score = 39.7 bits (91), Expect = 0.007 Identities = 22/68 (32%), Positives = 35/68 (51%), Gaps = 1/68 (1%) Frame = +3 Query: 327 GDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPEN 503 GD ++M+ L G SL D + M +A + E + LE +H+ +H D+K +N Sbjct: 316 GDELFVVMEYLAGGSLTDV--VTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDN 373 Query: 504 FLLGQPGT 527 LLG G+ Sbjct: 374 VLLGMEGS 381
>PAK2_HUMAN (Q13177) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 39.7 bits (91), Expect = 0.007 Identities = 22/68 (32%), Positives = 35/68 (51%), Gaps = 1/68 (1%) Frame = +3 Query: 327 GDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPEN 503 GD ++M+ L G SL D + M +A + E + LE +H+ +H D+K +N Sbjct: 316 GDELFVVMEYLAGGSLTDV--VTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDN 373 Query: 504 FLLGQPGT 527 LLG G+ Sbjct: 374 VLLGMEGS 381
>HAL4_YEAST (P25333) Serine/threonine-protein kinase HAL4/SAT4 (EC 2.7.11.1)| (Halotolerence protein 4) Length = 603 Score = 39.7 bits (91), Expect = 0.007 Identities = 41/146 (28%), Positives = 69/146 (47%), Gaps = 6/146 (4%) Frame = +3 Query: 105 RVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEV-AIK-FEHNTSKGCN-YGPPY--EWHV 269 R + LGKG FG V + ++ + G ++++ A+K F+ TS+ Y E+ + Sbjct: 317 RCQEVLGKGAFGVVRICQKKNVSSQDGNKSEKLYAVKEFKRRTSESAEKYSKRLTSEFCI 376 Query: 270 YSALGGTHGVPKVH-YKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAIS 446 S+L T+ V + ++ +G+Y ++ G L+ AG+ E C + I Sbjct: 377 SSSLHHTNIVTTLDLFQDAKGEYCEVMEYCAGGDLFTLVVAAGKLEYME-ADCFFKQLIR 435 Query: 447 ILESMHSKGYVHGDVKPENFLLGQPG 524 + MH G H D+KPEN LL G Sbjct: 436 GVVYMHEMGVCHRDLKPENLLLTHDG 461
>MAK_HUMAN (P20794) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 623 Score = 39.7 bits (91), Expect = 0.007 Identities = 35/164 (21%), Positives = 64/164 (39%), Gaps = 8/164 (4%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 Y R+LG G +G V +G+ + +G + + KF Y W L Sbjct: 4 YTTMRQLGDGTYGSVLMGK--SNESGELVAIKRMKRKF-------------YSWDECMNL 48 Query: 282 GGTHGVPKVHYKG--------RQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAE 437 + K+++ R+ D+ I + + +L+ + ++ I + Sbjct: 49 REVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQ 108 Query: 438 AISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 + L +H G+ H D+KPEN L P + + + D GLA Sbjct: 109 ILQGLAFIHKHGFFHRDMKPENLLCMGP-----ELVKIADFGLA 147
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 39.7 bits (91), Expect = 0.007 Identities = 26/83 (31%), Positives = 40/83 (48%) Frame = +3 Query: 333 YYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAEAISILESMHSKGYVHGDVKPENFLL 512 +Y++ G L+D G+ + V I E +S ++ MHS+ VH D+KPEN L Sbjct: 111 FYIITQLAKGGELFDRILKKGKFTEEDAVR-ILVEILSAVKYMHSQNIVHRDLKPENLLY 169 Query: 513 GQPGTPQEKKLFLVDLGLATKWK 581 E L + D G+A + K Sbjct: 170 IDKS--DESPLVVADFGIAKRLK 190
>CSK23_ARATH (O64817) Probable casein kinase II subunit alpha (EC 2.7.11.1) (CK| II) Length = 333 Score = 39.7 bits (91), Expect = 0.007 Identities = 44/170 (25%), Positives = 73/170 (42%), Gaps = 6/170 (3%) Frame = +3 Query: 78 VQIGGSPEYRVERKLGKGGFGHVFVGRRLTGGNGRGA-----GAQEVAIKFEHNTSKGCN 242 VQ G +Y V RK+G+G + VF G+ + N R ++ IK E + Sbjct: 26 VQWGHQDDYEVVRKVGRGKYSEVFEGKNVNT-NERCVIKILKPVKKKKIKREIKILQNLC 84 Query: 243 YGPPYEWHVYSALGGTHG-VPKVHYKGRQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMV 419 GP +Y + H P + ++ +V +D + + T++ + Sbjct: 85 GGPNIV-KLYDIVRDEHSKTPSLVFE------FVNSVD---------FKVLYPTLTDYDI 128 Query: 420 ACIAAEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 E + L+ HS+G +H DVKP N ++ Q +KL L+D GLA Sbjct: 129 RYYIYELLKALDFCHSQGIMHRDVKPHNVMIDH----QLRKLRLIDWGLA 174
>MAK_RAT (P20793) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 622 Score = 39.7 bits (91), Expect = 0.007 Identities = 35/164 (21%), Positives = 64/164 (39%), Gaps = 8/164 (4%) Frame = +3 Query: 102 YRVERKLGKGGFGHVFVGRRLTGGNGRGAGAQEVAIKFEHNTSKGCNYGPPYEWHVYSAL 281 Y R+LG G +G V +G+ + +G + + KF Y W L Sbjct: 4 YTTMRQLGDGTYGSVLMGK--SNESGELVAIKRMKRKF-------------YSWDECMNL 48 Query: 282 GGTHGVPKVHYKG--------RQGDYYVMIMDMLGPSLWDSWNLAGQTMSSEMVACIAAE 437 + K+++ R+ D+ I + + +L+ + ++ I + Sbjct: 49 REVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQ 108 Query: 438 AISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 + L +H G+ H D+KPEN L P + + + D GLA Sbjct: 109 ILQGLAFIHKHGFFHRDMKPENLLCMGP-----ELVKIADFGLA 147
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 39.7 bits (91), Expect = 0.007 Identities = 22/56 (39%), Positives = 32/56 (57%) Frame = +3 Query: 432 AEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 AE +S LE +H KG +H D+KPEN LL ++ + + D G A K P ++Q Sbjct: 187 AEIVSALEYLHGKGIIHRDLKPENILLN-----EDMHIQITDFGTA-KVLSPESKQ 236
>GPRK1_DROME (P32865) G protein-coupled receptor kinase 1 (EC 2.7.11.16)| Length = 700 Score = 39.7 bits (91), Expect = 0.007 Identities = 46/162 (28%), Positives = 68/162 (41%), Gaps = 5/162 (3%) Frame = +3 Query: 99 EYRVERKLGKGGFGHVFVGRRLTGGNGRGAGA-QEVAIKFEHNTSKGCNYGPPYEWHVYS 275 ++ V R +G+GGFG V+ R+ G + IK + N E ++ Sbjct: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALN-----ERNMLQ 244 Query: 276 ALGGTHGVPKV---HYKGRQGDYYVMIMDML-GPSLWDSWNLAGQTMSSEMVACIAAEAI 443 A+ P + Y D I+D++ G L + G EM AAE I Sbjct: 245 AVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEM-KFYAAEVI 303 Query: 444 SILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLA 569 LE MH + V+ D+KP N LL + G + + DLGLA Sbjct: 304 LGLEHMHKRCIVYRDLKPANILLDENG-----HIRISDLGLA 340
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 39.7 bits (91), Expect = 0.007 Identities = 22/56 (39%), Positives = 32/56 (57%) Frame = +3 Query: 432 AEAISILESMHSKGYVHGDVKPENFLLGQPGTPQEKKLFLVDLGLATKWKDPATQQ 599 AE +S LE +H KG +H D+KPEN LL ++ + + D G A K P ++Q Sbjct: 190 AEIVSALEYLHGKGIIHRDLKPENILLN-----EDMHIQITDFGTA-KVLSPESKQ 239 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 88,205,615 Number of Sequences: 219361 Number of extensions: 1952669 Number of successful extensions: 7830 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6967 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7629 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5710231900 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
