ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | baalb06 |
|---|---|
| Clone Library Name | barley_pub |
>MHK_ARATH (P43294) Serine/threonine-protein kinase MHK (EC 2.7.11.22)| Length = 443 Score = 262 bits (669), Expect = 7e-70 Identities = 121/182 (66%), Positives = 148/182 (81%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGIVKIADFG 248 NLY +++ER PFSE EIR FM Q+LQGL +MH NGYFHRDLKPENLLV+N I+KIADFG Sbjct: 93 NLYHIMKERERPFSEGEIRSFMSQMLQGLAHMHKNGYFHRDLKPENLLVTNNILKIADFG 152 Query: 249 LAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETE 428 LAREV S PPYT+YVSTRWYRAPEVLLQ+S YTP++DMWA+GAILAEL+ L+PLFPGE+E Sbjct: 153 LAREVASMPPYTEYVSTRWYRAPEVLLQSSLYTPAVDMWAVGAILAELYALTPLFPGESE 212 Query: 429 TDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLC 608 DQL+KIC VLG PD + +PE ++ R S + P + +L+PNA+ EA+DLI +LC Sbjct: 213 IDQLYKICCVLGKPDWTTFPEAKSISRIMSISHTEFPQTRIADLLPNAAPEAIDLINRLC 272 Query: 609 SW 614 SW Sbjct: 273 SW 274
>MAK_RAT (P20793) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 622 Score = 228 bits (580), Expect = 1e-59 Identities = 109/183 (59%), Positives = 140/183 (76%), Gaps = 1/183 (0%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLL-VSNGIVKIADF 245 NLY ++++R+ F E IR M QILQGL ++H +G+FHRD+KPENLL + +VKIADF Sbjct: 85 NLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADF 144 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLARE+ S PPYTDYVSTRWYRAPEVLL++S Y+ ID+WA+G+I+AEL+T PLFPG + Sbjct: 145 GLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFRPLFPGTS 204 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 E D++FKIC VLGTP S WPEG L S +F+F Q P NL LIPNAS EA+ L+ ++ Sbjct: 205 EVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTEM 264 Query: 606 CSW 614 +W Sbjct: 265 LNW 267
>MAK_MOUSE (Q04859) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) (Protein kinase RCK) Length = 622 Score = 228 bits (580), Expect = 1e-59 Identities = 109/183 (59%), Positives = 140/183 (76%), Gaps = 1/183 (0%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLL-VSNGIVKIADF 245 NLY ++++R+ F E IR M QILQGL ++H +G+FHRD+KPENLL + +VKIADF Sbjct: 85 NLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADF 144 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLARE+ S PPYTDYVSTRWYRAPEVLL++S Y+ ID+WA+G+I+AEL+T PLFPG + Sbjct: 145 GLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFRPLFPGTS 204 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 E D++FKIC VLGTP S WPEG L S +F+F Q P NL LIPNAS EA+ L+ ++ Sbjct: 205 EVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTEM 264 Query: 606 CSW 614 +W Sbjct: 265 LNW 267
>MAK_HUMAN (P20794) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 623 Score = 227 bits (578), Expect = 2e-59 Identities = 109/183 (59%), Positives = 140/183 (76%), Gaps = 1/183 (0%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLL-VSNGIVKIADF 245 NLY ++++R+ F E IR M QILQGL ++H +G+FHRD+KPENLL + +VKIADF Sbjct: 85 NLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADF 144 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLARE+ S PPYTDYVSTRWYRAPEVLL++S Y+ ID+WA+G+I+AEL+ L PLFPG + Sbjct: 145 GLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTS 204 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 E D++FKIC VLGTP S WPEG L S +F+F Q P NL LIPNAS EA+ L+ ++ Sbjct: 205 EVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEM 264 Query: 606 CSW 614 +W Sbjct: 265 LNW 267
>ICK_HUMAN (Q9UPZ9) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2) Length = 632 Score = 226 bits (575), Expect = 5e-59 Identities = 108/183 (59%), Positives = 138/183 (75%), Gaps = 1/183 (0%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLL-VSNGIVKIADF 245 NLY +I+ER+ F E IR M QILQGL ++H +G+FHRDLKPENLL + +VKIADF Sbjct: 85 NLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADF 144 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLARE+ S PPYTDYVSTRWYRAPEVLL+++ Y+ ID+WA+G I+AE++TL PLFPG + Sbjct: 145 GLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGAS 204 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 E D +FKIC VLGTP + WPEG L + +F++ Q P NL LIPNAS EA+ L++ + Sbjct: 205 EIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDM 264 Query: 606 CSW 614 W Sbjct: 265 LQW 267
>ICK_MOUSE (Q9JKV2) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK) Length = 629 Score = 225 bits (574), Expect = 7e-59 Identities = 109/183 (59%), Positives = 137/183 (74%), Gaps = 1/183 (0%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLL-VSNGIVKIADF 245 NLY +I+ER+ F E IR M QILQGL ++H +G+FHRDLKPENLL + +VKIADF Sbjct: 85 NLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADF 144 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLARE+ S PPYTDYVSTRWYRAPEVLL+++ Y+ ID+WA+G I+AE++TL PLFPG + Sbjct: 145 GLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEVYTLRPLFPGAS 204 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 E D +FKIC VLGTP + WPEG L + +F + Q P NL LIPNAS EA+ L++ L Sbjct: 205 EIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQCIPNNLKTLIPNASSEAIQLLRDL 264 Query: 606 CSW 614 W Sbjct: 265 LQW 267
>ICK_RAT (Q62726) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (MAK-related kinase) (MRK) Length = 629 Score = 225 bits (573), Expect = 9e-59 Identities = 109/183 (59%), Positives = 137/183 (74%), Gaps = 1/183 (0%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLL-VSNGIVKIADF 245 NLY +I+ER+ F E IR M QILQGL ++H +G+FHRDLKPENLL + +VKIADF Sbjct: 85 NLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADF 144 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLARE+ S PPYTDYVSTRWYRAPEVLL+++ Y+ ID+WA+G I+AE++TL PLFPG + Sbjct: 145 GLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGAS 204 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 E D +FKIC VLGTP + WPEG L + +F + Q P NL LIPNAS EA+ L++ L Sbjct: 205 EIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFIWPQCIPNNLKTLIPNASSEAIQLLRDL 264 Query: 606 CSW 614 W Sbjct: 265 LQW 267
>PIT1_SCHPO (O14132) Sporulation protein kinase pit1 (EC 2.7.11.1)| Length = 650 Score = 164 bits (415), Expect = 2e-40 Identities = 85/201 (42%), Positives = 123/201 (61%), Gaps = 18/201 (8%) Frame = +3 Query: 66 CNLYDVIRER-SAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI----- 227 CNLY +I R + P + E+++ M QI +GL ++H NG+FHRD+KPEN+L+S+ Sbjct: 119 CNLYQLISTRKNDPLTLEQVQDIMRQIFKGLNHIHTNGFFHRDMKPENILISSNSDSSSF 178 Query: 228 -VKIADFGLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLS 404 VKIADFGLARE+ S PPYT+YVSTRWYRAPE+LL+ S Y+ +D++A G + E+ TL Sbjct: 179 NVKIADFGLAREINSRPPYTEYVSTRWYRAPELLLRDSYYSFPVDIYAAGCMAFEIATLQ 238 Query: 405 PLFPGETETDQLFKICAVLGTPDH----------SLWPEGMNLPRSSSFQFFQIPPRNLW 554 P+FPG + DQL+K+C +LG+PD +W L ++ P + Sbjct: 239 PIFPGNDDFDQLYKMCEILGSPDEQSQNTGDKGGGIWDRAELLANKLGISLPKMAPLDFG 298 Query: 555 ELI-PNASLEALDLIKQLCSW 614 +L P +L ++ QL W Sbjct: 299 DLFSPPWNLAFASMLSQLLKW 319
>CCRK_PONPY (Q5R7I7) Cell cycle-related kinase (EC 2.7.11.22)| Length = 346 Score = 155 bits (393), Expect = 7e-38 Identities = 78/181 (43%), Positives = 116/181 (64%), Gaps = 3/181 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L +V+R P ++ +++ ++ +L+G+ + H N HRDLKP NLL+S +G +KIADF Sbjct: 87 DLAEVVRHAQRPLAQAQVKSYLQMLLKGVSFCHANNIVHRDLKPANLLISASGQLKIADF 146 Query: 246 GLAREVC--STPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPG 419 GLAR + YT V+TRWYRAPE+L A Y +D+WA+G I+ EL SPLFPG Sbjct: 147 GLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPG 206 Query: 420 ETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIK 599 + + +QL + +LGTP+ +WPE LP + F + P L E++P+AS +ALDL+ Sbjct: 207 KNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQAPVPLEEVLPDASPQALDLLG 266 Query: 600 Q 602 Q Sbjct: 267 Q 267
>CCRK_RAT (Q4KM34) Cell cycle-related kinase (EC 2.7.11.22)| Length = 346 Score = 155 bits (391), Expect = 1e-37 Identities = 79/181 (43%), Positives = 113/181 (62%), Gaps = 3/181 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L +V+R P + +++ ++ +L+G+ + H N HRDLKP NLL+S +G +KIADF Sbjct: 87 DLAEVVRHAQRPLAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADF 146 Query: 246 GLAREVCSTPP--YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPG 419 GLAR YT V+TRWYRAPE+L A Y +D+WA+G I+ EL SPLFPG Sbjct: 147 GLARVFSPDGGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPG 206 Query: 420 ETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIK 599 E + +QL + +LGTP +WPE LP + F + P L E++P+AS +ALDL+ Sbjct: 207 ENDIEQLCCVLRILGTPSPRVWPEITELPDYNKISFKEQAPVPLEEVLPDASHQALDLLG 266 Query: 600 Q 602 Q Sbjct: 267 Q 267
>CCRK_MOUSE (Q9JHU3) Cell cycle-related kinase (EC 2.7.11.22)| (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) Length = 346 Score = 155 bits (391), Expect = 1e-37 Identities = 79/181 (43%), Positives = 113/181 (62%), Gaps = 3/181 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L +V+R P + +++ ++ +L+G+ + H N HRDLKP NLL+S +G +KIADF Sbjct: 87 DLAEVVRHAQRPLAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADF 146 Query: 246 GLAREVCSTPP--YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPG 419 GLAR YT V+TRWYRAPE+L A Y +D+WA+G I+ EL SPLFPG Sbjct: 147 GLARVFSPDGGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPG 206 Query: 420 ETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIK 599 E + +QL + +LGTP +WPE LP + F + P L E++P+AS +ALDL+ Sbjct: 207 ENDIEQLCCVLRILGTPSPRVWPEITELPDYNKISFKEQAPVPLEEVLPDASPQALDLLG 266 Query: 600 Q 602 Q Sbjct: 267 Q 267
>MOK_MOUSE (Q9WVS4) MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK| protein kinase) Length = 420 Score = 154 bits (389), Expect = 2e-37 Identities = 81/198 (40%), Positives = 114/198 (57%) Frame = +3 Query: 21 DGKITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKP 200 D K S + N+Y++IR R P SE++I +M Q+ + L +MH NG FHRD+KP Sbjct: 72 DRKSGSLALICELMDMNIYELIRGRRHPLSEKKIMLYMYQLCKSLDHMHRNGIFHRDVKP 131 Query: 201 ENLLVSNGIVKIADFGLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAI 380 EN+LV ++K+ DFG R V S PYT+Y+STRWYRAPE LL YT +D+W+ G + Sbjct: 132 ENILVKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCV 191 Query: 381 LAELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWEL 560 E+ +L PLFPG E DQ+ KI V+GTP + R+ SF F + L Sbjct: 192 FYEIASLQPLFPGVNELDQISKIHDVIGTPCQKTLTK-FKQSRAMSFDFPFKKGSGIPLL 250 Query: 561 IPNASLEALDLIKQLCSW 614 N S + L L+ + ++ Sbjct: 251 TANLSPQCLSLLHAMVAY 268
>CCRK_HUMAN (Q8IZL9) Cell cycle-related kinase (EC 2.7.11.22)| (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) Length = 346 Score = 154 bits (389), Expect = 2e-37 Identities = 76/181 (41%), Positives = 115/181 (63%), Gaps = 3/181 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L +V+R P ++ +++ ++ +L+G+ + H N HRDLKP NLL+S +G +KIADF Sbjct: 87 DLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADF 146 Query: 246 GLAREVC--STPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPG 419 GLAR + YT V+TRWYRAPE+L A Y +D+W++G I+ EL SPLFPG Sbjct: 147 GLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPG 206 Query: 420 ETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIK 599 + + +QL + +LGTP+ +WPE LP + F + P L E++P+ S +ALDL+ Sbjct: 207 KNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLG 266 Query: 600 Q 602 Q Sbjct: 267 Q 267
>MOK_HUMAN (Q9UQ07) MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK| protein kinase) (Renal tumor antigen 1) (RAGE-1) Length = 419 Score = 153 bits (386), Expect = 4e-37 Identities = 78/198 (39%), Positives = 115/198 (58%) Frame = +3 Query: 21 DGKITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKP 200 D K S + N+Y++IR R P SE++I +M Q+ + L ++H NG FHRD+KP Sbjct: 72 DRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKP 131 Query: 201 ENLLVSNGIVKIADFGLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAI 380 EN+L+ ++K+ DFG R V S PYT+Y+STRWYRAPE LL YT +D+W+ G + Sbjct: 132 ENILIKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCV 191 Query: 381 LAELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWEL 560 E+ +L PLFPG E DQ+ KI V+GTP + + R+ +F F + L Sbjct: 192 FYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTK-FKQSRAMNFDFPFKKGSGIPLL 250 Query: 561 IPNASLEALDLIKQLCSW 614 N S + L L+ + ++ Sbjct: 251 TTNLSPQCLSLLHAMVAY 268
>MDE3_SCHPO (O43077) Sporulation protein kinase mde3 (EC 2.7.11.1)| (Mei4-dependent protein 3) Length = 559 Score = 149 bits (375), Expect = 8e-36 Identities = 77/200 (38%), Positives = 116/200 (58%), Gaps = 17/200 (8%) Frame = +3 Query: 66 CNLYDVIRERSAP-FSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV--------- 215 CNL+ + + R F++E +LQI+ G+ ++H +G+ HRD+KPEN+LV Sbjct: 108 CNLFQLFKRRQGRLFTKETAFNILLQIISGIEHIHKHGFMHRDIKPENILVKRISPKPIS 167 Query: 216 SNGIVKIADFGLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELF 395 S +K+ DFGLAR S+ P T+YVSTRWYRAPE+LL++ +Y S+D++A G I+ E++ Sbjct: 168 SRYSIKLGDFGLARPSVSSDPLTEYVSTRWYRAPELLLRSGSYNHSVDLYAFGCIVFEIY 227 Query: 396 TLSPLFPGETETDQLFKICAVLGTPDHS------LWPEGMNLPRSSSFQFFQIPPRNLWE 557 +L PLFPG ETDQL ++C +LG P W + L + F P + + Sbjct: 228 SLKPLFPGRNETDQLNRVCEILGNPGIDELDTLHYWSQAKELAKRLGFMLPPTKPYPIQK 287 Query: 558 LIPNASLEA-LDLIKQLCSW 614 L+P E +I L +W Sbjct: 288 LLPQNCPEGHAKMIPCLLAW 307
>CDK7_HUMAN (P50613) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) Length = 346 Score = 145 bits (367), Expect = 7e-35 Identities = 84/199 (42%), Positives = 114/199 (57%), Gaps = 2/199 (1%) Frame = +3 Query: 15 GDDGKITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDL 194 G I+ F+ T +L +I++ S + I+ +ML LQGL Y+H + HRDL Sbjct: 82 GHKSNISLVFDFMET---DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDL 138 Query: 195 KPENLLVS-NGIVKIADFGLAREVCS-TPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWA 368 KP NLL+ NG++K+ADFGLA+ S YT V TRWYRAPE+L A Y +DMWA Sbjct: 139 KPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWA 198 Query: 369 IGAILAELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRN 548 +G ILAEL P PG+++ DQL +I LGTP WP+ +LP +F+ F P Sbjct: 199 VGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF--PGIP 256 Query: 549 LWELIPNASLEALDLIKQL 605 L + A + LDLI+ L Sbjct: 257 LHHIFSAAGDDLLDLIQGL 275
>CD2L2_HUMAN (Q9UQ88) PITSLRE serine/threonine-protein kinase CDC2L2 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11) Length = 780 Score = 145 bits (366), Expect = 9e-35 Identities = 73/163 (44%), Positives = 101/163 (61%), Gaps = 2/163 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ PF E++ M+Q+L+G+ ++H+N HRDLK NLL+S+ GI+K+ DF Sbjct: 507 DLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDF 566 Query: 246 GLAREVCST-PPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGE 422 GLARE S YT V T+WYRAPE+LL A Y+ ++DMW++G I EL T PLFPG Sbjct: 567 GLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGN 626 Query: 423 TETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNL 551 +E DQ+ K+ LGTP +WP LP F + P NL Sbjct: 627 SEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNL 669
>CD2L1_HUMAN (P21127) PITSLRE serine/threonine-protein kinase CDC2L1 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1) Length = 795 Score = 145 bits (365), Expect = 1e-34 Identities = 73/163 (44%), Positives = 101/163 (61%), Gaps = 2/163 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ PF E++ M+Q+L+G+ ++H+N HRDLK NLL+S+ GI+K+ DF Sbjct: 522 DLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDF 581 Query: 246 GLAREVCST-PPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGE 422 GLARE S YT V T WYRAPE+LL A Y+ ++DMW++G I EL T PLFPG+ Sbjct: 582 GLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGK 641 Query: 423 TETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNL 551 +E DQ+ K+ LGTP +WP LP F + P NL Sbjct: 642 SEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNL 684
>CD2L1_MOUSE (P24788) PITSLRE serine/threonine-protein kinase CDC2L1 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) Length = 784 Score = 144 bits (364), Expect = 2e-34 Identities = 73/163 (44%), Positives = 101/163 (61%), Gaps = 2/163 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ PF E++ M+Q+L G+ ++H+N HRDLK NLL+S+ GI+K+ DF Sbjct: 511 DLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDF 570 Query: 246 GLAREVCST-PPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGE 422 GLARE S YT V T WYRAPE+LL A Y+ ++DMW++G I EL T PLFPG+ Sbjct: 571 GLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGK 630 Query: 423 TETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNL 551 ++ DQ+ KI LGTP +WP +LP F + P NL Sbjct: 631 SDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNL 673
>CDC2B_ANTMA (Q38773) Cell division control protein 2 homolog B (EC 2.7.11.22)| (EC 2.7.11.23) (Fragment) Length = 280 Score = 144 bits (362), Expect = 3e-34 Identities = 71/162 (43%), Positives = 103/162 (63%), Gaps = 3/162 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNG--IVKIADFGLAREV-CSTPPYTDY 290 ++ F+ QIL+G+ Y H++ HRDLKP+NLL+ G +K+ADFGLAR +T Sbjct: 91 VKMFLCQILRGVAYCHSHRVLHRDLKPQNLLIDRGSNTIKLADFGLARAFGIPVRTFTHE 150 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAPEVLL + Y+ +D+W++G I AE+ PLFPG++E D+L KI ++GTP Sbjct: 151 VVTLWYRAPEVLLGSRHYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELHKIFRIIGTP 210 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLI 596 + +WP +LP S F + PP+ L ++PN LDL+ Sbjct: 211 NEDIWPGVTSLPDFKS-SFPKWPPKELATIVPNLGATGLDLL 251
>CDK7_MOUSE (Q03147) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinas Length = 346 Score = 143 bits (361), Expect = 3e-34 Identities = 83/199 (41%), Positives = 114/199 (57%), Gaps = 2/199 (1%) Frame = +3 Query: 15 GDDGKITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDL 194 G I+ F+ T +L +I++ S + I+ +ML LQGL Y+H + HRDL Sbjct: 82 GHKSNISLVFDFMET---DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDL 138 Query: 195 KPENLLVS-NGIVKIADFGLAREVCS-TPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWA 368 KP NLL+ NG++K+ADFGLA+ S YT V TRWYRAPE+L A Y +DMWA Sbjct: 139 KPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWA 198 Query: 369 IGAILAELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRN 548 +G ILAEL P PG+++ DQL +I LGTP WP+ +LP +F+ F P Sbjct: 199 VGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF--PGVP 256 Query: 549 LWELIPNASLEALDLIKQL 605 L + A + L+LI+ L Sbjct: 257 LQHIFIAAGDDLLELIQGL 275
>CDK3_HUMAN (Q00526) Cell division protein kinase 3 (EC 2.7.11.22)| Length = 305 Score = 143 bits (361), Expect = 3e-34 Identities = 74/167 (44%), Positives = 104/167 (62%), Gaps = 2/167 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 I+ ++ Q+LQG+ + H++ HRDLKP+NLL++ G +K+ADFGLAR YT V Sbjct: 104 IKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEV 163 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPE+LL + YT ++D+W+IG I AE+ T LFPG++E DQLF+I +LGTP Sbjct: 164 VTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPS 223 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 WP LP F + + L E++PN E DL+ QL + Sbjct: 224 EDTWPGVTQLPDYKG-SFPKWTRKGLEEIVPNLEPEGRDLLMQLLQY 269
>CDK7_RAT (P51952) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 protein kinase) (P39 Mo15) (Fragment) Length = 329 Score = 143 bits (360), Expect = 5e-34 Identities = 83/199 (41%), Positives = 114/199 (57%), Gaps = 2/199 (1%) Frame = +3 Query: 15 GDDGKITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDL 194 G I+ F+ T +L +I++ S + I+ +ML LQGL Y+H + HRDL Sbjct: 74 GHKSNISLVFDFMET---DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDL 130 Query: 195 KPENLLVS-NGIVKIADFGLAREVCSTP-PYTDYVSTRWYRAPEVLLQASAYTPSIDMWA 368 KP NLL+ NG++K+ADFGLA+ S YT V TRWYRAPE+L A Y +DMWA Sbjct: 131 KPNNLLLDENGVLKLADFGLAKSFGSPNWAYTHQVVTRWYRAPELLFGARMYGVGVDMWA 190 Query: 369 IGAILAELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRN 548 +G ILAEL P PG+++ DQL +I LGTP WP+ +LP +F+ F P Sbjct: 191 VGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF--PGIP 248 Query: 549 LWELIPNASLEALDLIKQL 605 L + A + L+LI+ L Sbjct: 249 LQHIFIAAGDDLLELIQGL 267
>CDK7_CARAU (P51953) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (40 kDa protein kinase) (P40 MO15) (CDC2/CDK2,4-activating kinase) Length = 344 Score = 142 bits (359), Expect = 6e-34 Identities = 80/177 (45%), Positives = 105/177 (59%), Gaps = 2/177 (1%) Frame = +3 Query: 81 VIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAR 257 +I++ S + I+ ++L LQGL YMHN+ HRDLKP NLL+ NG++K+ADFGLA+ Sbjct: 100 IIKDTSLVLTPANIKAYILMSLQGLEYMHNHWILHRDLKPNNLLLDENGVLKLADFGLAK 159 Query: 258 EVCS-TPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETD 434 S YT V TRWYRAPE+L A Y +DMWA+G+ILAEL P G+++ D Sbjct: 160 AFGSPNRVYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGSILAELLLRVPFLAGDSDLD 219 Query: 435 QLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 QL I LGTP WP NLP SF+ F P L + A + L+L+K L Sbjct: 220 QLTGIFEALGTPTEETWPGMSNLPDYVSFKLF--PGTPLEHIFSAAGDDLLELLKGL 274
>CDC22_MEDSA (Q05006) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 294 Score = 142 bits (358), Expect = 8e-34 Identities = 73/169 (43%), Positives = 104/169 (61%), Gaps = 3/169 (1%) Frame = +3 Query: 111 EEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV--SNGIVKIADFGLAREV-CSTPPY 281 + +I+ F+ QIL G+ Y H++ HRDLKP+NLL+ S+ VK+ADFGLAR + Sbjct: 101 QRQIKMFLYQILCGIAYCHSHRVLHRDLKPQNLLIDRSSNAVKLADFGLARAFGIPVRTF 160 Query: 282 TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVL 461 T V T WYRAPE+LL + Y+ +D+W++G I AE+ PLFPG++E D+LFKI + Sbjct: 161 THEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMINQRPLFPGDSEIDELFKIFRIT 220 Query: 462 GTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLC 608 GTP+ WP +LP S F + P ++L +PN LDL+ C Sbjct: 221 GTPNEETWPGVTSLPDFKS-AFPKWPAKDLATQVPNLEPAGLDLLSSTC 268
>CD2L1_RAT (P46892) PITSLRE serine/threonine-protein kinase CDC2L1 (EC| 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) Length = 436 Score = 142 bits (358), Expect = 8e-34 Identities = 71/163 (43%), Positives = 100/163 (61%), Gaps = 2/163 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ PF E++ M+Q+L G+ ++H+N HRDLK NLL+++ GI+K+ DF Sbjct: 163 DLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLTHAGILKVGDF 222 Query: 246 GLAREVCST-PPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGE 422 GLARE S YT V T WYRAPE+LL A Y+ + DMW++G I EL T PLFPG+ Sbjct: 223 GLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTACDMWSVGCIFGELLTQKPLFPGK 282 Query: 423 TETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNL 551 ++ DQ+ KI +GTP +WP LP F ++P NL Sbjct: 283 SDIDQINKIFKDIGTPSEKIWPGYSELPAVKKMTFSELPYNNL 325
>CDC28_YEAST (P00546) Cell division control protein 28 (EC 2.7.11.22)| Length = 298 Score = 142 bits (357), Expect = 1e-33 Identities = 70/176 (39%), Positives = 111/176 (63%), Gaps = 2/176 (1%) Frame = +3 Query: 93 RSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-C 266 + P + ++KFM+Q+ +G+ Y H++ HRDLKP+NLL++ +G +K+ DFGLAR Sbjct: 104 KDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGV 163 Query: 267 STPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFK 446 YT + T WYRAPEVLL Y+ +D W+IG I AE+ P+F G++E DQ+FK Sbjct: 164 PLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFK 223 Query: 447 ICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 I VLGTP+ ++WP+ + LP F Q ++L +++P+ +DL+ +L ++ Sbjct: 224 IFRVLGTPNEAIWPDIVYLPDFKP-SFPQWRRKDLSQVVPSLDPRGIDLLDKLLAY 278
>CDC2_DICDI (P34112) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 296 Score = 142 bits (357), Expect = 1e-33 Identities = 77/169 (45%), Positives = 106/169 (62%), Gaps = 4/169 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREVCSTPP--YTDY 290 I+ ++ Q+L+GL Y H + HRDLKP+NLL+ G +K+ADFGLAR V S P YT Sbjct: 106 IKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAV-SIPVRVYTHE 164 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + T WYRAPEVLL + +Y+ +DMW++G I E+ PLF G+ E DQ+F+I VLGTP Sbjct: 165 IVTLWYRAPEVLLGSKSYSVPVDMWSVGCIFGEMLNKKPLFSGDCEIDQIFRIFRVLGTP 224 Query: 471 DHSLWPEGMNLPR-SSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 D S+WP LP S+F + P N ++ P ALDLI ++ + Sbjct: 225 DDSIWPGVTKLPEYVSTFPNWPGQPYN--KIFPRCEPLALDLIAKMLQY 271
>CDC2_CARAU (P51958) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 302 Score = 141 bits (356), Expect = 1e-33 Identities = 73/164 (44%), Positives = 105/164 (64%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QIL+G+++ H HRDLKP+NLL+ N G++K+ADFGLAR YT V Sbjct: 105 VKSYLYQILEGILFCHCRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPEVLL AS Y+ +D+W+IG I AEL T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRAPEVLLGASRYSTPVDVWSIGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WP+ +LP + F + NL + N +DL+ ++ Sbjct: 225 NEVWPDVESLPDYKN-TFPKWKSGNLASTVKNLDKNGIDLLTKM 267
>CDC2_AJECA (P54119) Cell division control protein 2 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent protein kinase) Length = 324 Score = 141 bits (356), Expect = 1e-33 Identities = 72/170 (42%), Positives = 105/170 (61%), Gaps = 2/170 (1%) Frame = +3 Query: 111 EEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYT 284 E ++KFM Q+++G+ Y H++ HRDLKP+NLL+ G +K+ADFGLAR YT Sbjct: 122 EAMVKKFMAQLVEGIRYCHSHRVLHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRTYT 181 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 V T WYRAPE+LL Y+ +DMW++GAI AE+ T PLFPG++E D++FKI +LG Sbjct: 182 HEVVTLWYRAPEILLGGRQYSTGVDMWSVGAIFAEMCTRKPLFPGDSEIDEIFKIFKLLG 241 Query: 465 TPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 TPD + WP + P + F + + +L+P LDL+ + + Sbjct: 242 TPDENTWPGVTSFPDFKA-SFPKWKREDTRKLVPGLERNGLDLLDAMLEY 290
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 141 bits (356), Expect = 1e-33 Identities = 75/167 (44%), Positives = 111/167 (66%), Gaps = 3/167 (1%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTD 287 ++++ FM Q+L+G+++ H+N HRDLKP+NLL++ G +K+ADFGLAR +++ Sbjct: 105 KQVKWFMYQLLRGILFCHDNRVLHRDLKPQNLLINAKGQLKLADFGLARAFGIPVNTFSN 164 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGT 467 V T WYRAP+VLL + Y+ SID+W+ G I+AE+FT PLFPG + DQL I ++GT Sbjct: 165 EVVTLWYRAPDVLLGSRTYSTSIDIWSAGCIMAEMFTGRPLFPGSSNDDQLQHIFKLMGT 224 Query: 468 PDHSLWPEGMNLPR-SSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 P+ S WP +LP S+FQ + P++L +IP ALDL+ L Sbjct: 225 PNESTWPNISSLPNYRSNFQVY--APQDLRVIIPQIDNVALDLLLSL 269
>CDK7_DICDI (P54685) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (MO15 homolog) Length = 362 Score = 141 bits (356), Expect = 1e-33 Identities = 80/181 (44%), Positives = 110/181 (60%), Gaps = 2/181 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L +VI ++S +I+ +M +LQG+ H N HRDLKP NLL+S NG +K+ADF Sbjct: 90 DLQEVIEDKSIILKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSINGDLKLADF 149 Query: 246 GLAREVCS-TPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGE 422 GLAR+ S ++ T +YRAPE+L A +Y PS+D+W+IG I AEL +P PG Sbjct: 150 GLARQYGSPNKVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYLPGT 209 Query: 423 TETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQ 602 E DQL KIC+ LGTP+ S WP LP + +F P +L AS EA+DLI + Sbjct: 210 GEIDQLRKICSALGTPNESNWPGVTCLP--NYIKFTDHPATPFKQLFTAASDEAIDLISK 267 Query: 603 L 605 + Sbjct: 268 M 268
>CDC28_CANAL (P43063) Cell division control protein 28 (EC 2.7.11.22)| Length = 317 Score = 140 bits (354), Expect = 2e-33 Identities = 70/164 (42%), Positives = 104/164 (63%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 I++FM Q+++G+ + H++ HRDLKP+NLL+ G +K+ADFGLAR YT V Sbjct: 110 IKRFMNQLIRGIKHCHSHRVLHRDLKPQNLLIDKEGNLKLADFGLARAFGVPLRAYTHEV 169 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPE+LL Y+ +DMW++G I AE+ PLFPG++E D++F+I +LGTP+ Sbjct: 170 VTLWYRAPEILLGGKQYSTGVDMWSVGCIFAEMCNRKPLFPGDSEIDEIFRIFRILGTPN 229 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 +WP+ LP S F Q + L E +P+ +DL+ Q+ Sbjct: 230 EEIWPDVNYLPDFKS-SFPQWKKKPLSEAVPSLDANGIDLLDQM 272
>CDC2_EMENI (Q00646) Cell division control protein 2 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent protein kinase) Length = 323 Score = 140 bits (354), Expect = 2e-33 Identities = 70/176 (39%), Positives = 109/176 (61%), Gaps = 2/176 (1%) Frame = +3 Query: 93 RSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-C 266 R+ + ++KFM Q+++G+ + H++ HRDLKP+NLL+ +G +K+ADFGLAR Sbjct: 115 RNLGLGDAMVKKFMAQLIEGIRFCHSHRVLHRDLKPQNLLIDRDGNLKLADFGLARAFGV 174 Query: 267 STPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFK 446 YT V T WYR+PE+LL Y+ +DMW+ GAI AE+ T PLFPG++E D++FK Sbjct: 175 PLRTYTHEVVTLWYRSPEILLGGRQYSTGVDMWSCGAIFAEMCTRKPLFPGDSEIDEIFK 234 Query: 447 ICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 I +LGTPD ++WP + P F + ++ ++P + LDL++ L + Sbjct: 235 IFRILGTPDETIWPGVTSFPDFKP-TFPKWKREDIQNVVPGLEEDGLDLLEALLEY 289
>CDK10_HUMAN (Q15131) Cell division protein kinase 10 (EC 2.7.11.22)| (Serine/threonine-protein kinase PISSLRE) Length = 360 Score = 140 bits (353), Expect = 3e-33 Identities = 82/189 (43%), Positives = 106/189 (56%), Gaps = 4/189 (2%) Frame = +3 Query: 42 SSFLNTWXC--NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV 215 S FL C +L ++ PFSE +++ +LQ+L+GL Y+H N HRDLK NLL+ Sbjct: 112 SIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLM 171 Query: 216 SN-GIVKIADFGLAREV-CSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAE 389 ++ G VK ADFGLAR P T V T WYRAPE+LL + T SIDMWA+G ILAE Sbjct: 172 TDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAE 231 Query: 390 LFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPN 569 L PL PG +E Q+ I +LGTP ++WP LP + + P NL P Sbjct: 232 LLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPW 291 Query: 570 ASLEALDLI 596 S L L+ Sbjct: 292 LSEAGLRLL 300
>CDC22_XENLA (P24033) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 2) Length = 302 Score = 139 bits (351), Expect = 5e-33 Identities = 72/164 (43%), Positives = 106/164 (64%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QILQG+V+ H+ G HRDLKP+NLL+ N G++K+ADFGLAR YT V Sbjct: 105 VKSYLYQILQGIVFCHSRGVLHRDLKPQNLLIDNKGVIKLADFGLARAFGIPVRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPEVLL + Y+ +D+W++G I AE+ T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRAPEVLLGSVRYSTPVDVWSVGTIFAEIATKKPLFHGDSEIDQLFRIFRSLGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WPE +L + F + +L + N + LDL+ ++ Sbjct: 225 NEVWPEVESL-QDYKNTFPKWKGGSLSSNVKNIDEDGLDLLSKM 267
>CDC2_VIGUN (P52389) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 139 bits (351), Expect = 5e-33 Identities = 70/168 (41%), Positives = 104/168 (61%), Gaps = 3/168 (1%) Frame = +3 Query: 117 EIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN--GIVKIADFGLAREV-CSTPPYTD 287 +++ F+ QIL G+ Y H++ HRDLKP+NLL+ +K+ADFGLAR +T Sbjct: 103 QVKMFLYQILCGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTH 162 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGT 467 V T WYRAPE+LL + Y+ +D+W++G + AE+ PLFPG++E D+LFKI +LGT Sbjct: 163 EVVTLWYRAPEILLGSRHYSTPVDVWSVGCLFAEMVNRRPLFPGDSEIDELFKIFRILGT 222 Query: 468 PDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCS 611 P+ WP LP S F + PP++L ++PN L+L+ + S Sbjct: 223 PNEETWPGVTALPDFKS-TFPKWPPKDLATMVPNLDAAGLNLLSSMLS 269
>CDC2A_ANTMA (Q38772) Cell division control protein 2 homolog A (EC 2.7.11.22)| (EC 2.7.11.23) Length = 294 Score = 139 bits (351), Expect = 5e-33 Identities = 70/165 (42%), Positives = 103/165 (62%), Gaps = 3/165 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN--GIVKIADFGLAREV-CSTPPYTDY 290 ++ F+ QIL+G+ Y H++ HRDLKP+NLL+ +K+ADFGLAR +T Sbjct: 104 VKMFLYQILRGIAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPVRTFTHE 163 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAPE+LL + Y+ +D+W++G I AE+ PLFPG++E D+LFKI V+GTP Sbjct: 164 VVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMVNQRPLFPGDSEIDELFKIFRVMGTP 223 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + WP +LP S F + P + L ++PN LDL+ ++ Sbjct: 224 NEETWPGVTSLPDFKS-AFPKWPAKELAAVVPNLDASGLDLLDKM 267
>MPK4_ARATH (Q39024) Mitogen-activated protein kinase homolog 4 (EC 2.7.11.24)| (MAP kinase 4) (AtMPK4) Length = 376 Score = 139 bits (350), Expect = 7e-33 Identities = 78/185 (42%), Positives = 111/185 (60%), Gaps = 6/185 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L+ +IR P +++ R F+ Q+L+GL Y+H+ HRDLKP NLL++ N +K+ DF Sbjct: 130 DLHQIIRSNQ-PLTDDHCRFFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKLGDF 188 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLAR T T+YV TRWYRAPE+LL S YT +ID+W++G IL E T PLFPG+ Sbjct: 189 GLARTKSETDFMTEYVVTRWYRAPELLLNCSEYTAAIDIWSVGCILGETMTREPLFPGKD 248 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSF-----QFFQIPPRNLWELIPNASLEALD 590 QL I ++G+PD S + RS + Q Q P +N PN S A+D Sbjct: 249 YVHQLRLITELIGSPDDS----SLGFLRSDNARRYVRQLPQYPRQNFAARFPNMSAGAVD 304 Query: 591 LIKQL 605 L++++ Sbjct: 305 LLEKM 309
>KC47_ORYSA (P29620) CDC2+/CDC28-related protein kinase R2 (EC 2.7.11.22)| Length = 424 Score = 139 bits (349), Expect = 9e-33 Identities = 76/185 (41%), Positives = 110/185 (59%), Gaps = 3/185 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADF 245 +L VIR+R+ S + + ++ +L+GL + H HRD+KP NLL+ ++G +K+ADF Sbjct: 101 DLEAVIRDRNIVLSPADTKSYIQMMLKGLAFCHKKWVLHRDMKPNNLLIGADGQLKLADF 160 Query: 246 GLAREVCSTPP--YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPG 419 GLAR + +P +T V RWYRAPE+L Y ++D+WA G I AEL P G Sbjct: 161 GLAR-IFGSPERNFTHQVFARWYRAPELLFGTKQYGSAVDIWAAGCIFAELLLRRPFLQG 219 Query: 420 ETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIK 599 ++ DQL KI A GTP S WP+ + LP +QF PP L L P AS +ALDL+ Sbjct: 220 SSDIDQLGKIFAAFGTPKSSQWPDMVYLPDYVEYQFVSAPP--LRSLFPMASDDALDLLS 277 Query: 600 QLCSW 614 ++ ++ Sbjct: 278 RMFTY 282
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 139 bits (349), Expect = 9e-33 Identities = 71/164 (43%), Positives = 107/164 (65%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QILQG+V+ H+ HRDLKP+NLL+ + G++K+ADFGLAR YT V Sbjct: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGVIKLADFGLARAFGIPVRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR+PEVLL ++ Y+ +D+W+IG I AEL T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRSPEVLLGSALYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WP+ +L + F + P +L + N + LDL+ ++ Sbjct: 225 NDVWPDVESL-QDYKNTFPKWKPGSLGTHVQNLDEDGLDLLSKM 267
>CDC2_VIGAC (Q41639) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 139 bits (349), Expect = 9e-33 Identities = 70/166 (42%), Positives = 103/166 (62%), Gaps = 3/166 (1%) Frame = +3 Query: 117 EIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN--GIVKIADFGLAREV-CSTPPYTD 287 +++ F+ QIL G+ Y H++ HRDLKP+NLL+ +K+ADFGLAR +T Sbjct: 103 QVKMFLYQILCGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTH 162 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGT 467 V T WYRAPE+LL + Y+ +D+W++G I AE+ PLFPG++E D+LFKI +LGT Sbjct: 163 EVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMVNRRPLFPGDSEIDELFKIFRILGT 222 Query: 468 PDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 P+ WP LP S F + PP++L ++PN L+L+ + Sbjct: 223 PNEETWPGVTALPDFKS-TFPKWPPKDLATVVPNLDAAGLNLLSSM 267
>MMK2_MEDSA (Q40353) Mitogen-activated protein kinase homolog MMK2 (EC| 2.7.11.24) Length = 371 Score = 139 bits (349), Expect = 9e-33 Identities = 78/181 (43%), Positives = 109/181 (60%), Gaps = 2/181 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L+ +IR P +++ R F+ Q+L+GL Y+H+ HRDLKP NLL++ N +KI DF Sbjct: 124 DLHQIIRSNQ-PMTDDHCRYFVYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKIGDF 182 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLAR T T+YV TRWYRAPE+LL S YT +ID+W++G IL E+ T PLFPG Sbjct: 183 GLARTTSETDFMTEYVVTRWYRAPELLLNCSDYTAAIDIWSVGCILGEIVTRQPLFPGRD 242 Query: 426 ETDQLFKICAVLGTPDH-SLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQ 602 QL + ++G+PD SL R Q Q P +N PN S A+DL+++ Sbjct: 243 YVHQLRLVTELIGSPDDASLGFLRSENARRYVRQLPQYPKQNFSARFPNMSPGAVDLLEK 302 Query: 603 L 605 + Sbjct: 303 M 303
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 139 bits (349), Expect = 9e-33 Identities = 73/164 (44%), Positives = 105/164 (64%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QILQG+V+ H+ HRDLKP+NLL+ + G +K+ADFGLAR YT V Sbjct: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR+PEVLL ++ Y+ +D+W+IG I AEL T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRSPEVLLGSAGYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WPE +L S F + P +L + N LDL+ ++ Sbjct: 225 NEVWPEVESLQDYKS-TFPKWKPGSLASHVKNLDENGLDLLSKM 267
>SMK1_YEAST (P41808) Sporulation-specific mitogen-activated protein kinase SMK1| (EC 2.7.11.24) (MAP kinase SMK1) Length = 388 Score = 138 bits (348), Expect = 1e-32 Identities = 85/201 (42%), Positives = 117/201 (58%), Gaps = 21/201 (10%) Frame = +3 Query: 75 YDVIR--ERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 YD+ + S SE I+ F+ QIL GL Y+H+ HRDLKP N+L + NG +KI DF Sbjct: 126 YDLAKVIHSSVQLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDF 185 Query: 246 GLAREV------CST---PPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFT 398 GLAR + C + P T+YV+TRWYRAPE+LL Y+ S+D+WA+G ILAE + Sbjct: 186 GLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDIWAVGCILAEFYA 245 Query: 399 LSPLFPGETETDQLFKICAVLGTPDHSL---------WPEGMNLPRSSSFQFFQIPPRNL 551 P+F G Q+F+I VLGTPD + W G N S++ + +IP N+ Sbjct: 246 RKPVFMGRDSMHQIFEIIKVLGTPDKDILIKFGTIKAWNLGKN---SNNPVYKKIPWSNI 302 Query: 552 WELIPNASLEALDLIKQLCSW 614 + P AS EA++LI+ L W Sbjct: 303 F---PFASHEAINLIESLLHW 320
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 138 bits (348), Expect = 1e-32 Identities = 69/164 (42%), Positives = 105/164 (64%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ Q+LQGL + H++ HRDLKP+NLL++ G +K+ADFGLAR YT V Sbjct: 104 VKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQGEIKLADFGLARAFGVPVRTYTHEV 163 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPE+LL Y+ ++D+W++G I AE+ T LFPG++E DQLF+I LGTPD Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMITRKALFPGDSEIDQLFRIFRTLGTPD 223 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 S+WP ++P F + ++L +++P + DL+ Q+ Sbjct: 224 ESIWPGVTSMPDYKP-SFPKWARQDLSKVVPPLDEDGRDLLGQM 266
>CDK7_XENLA (P20911) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (40 kDa protein kinase) (P40 MO15) (CDC2/CDK2,4-activating kinase) Length = 352 Score = 138 bits (348), Expect = 1e-32 Identities = 77/181 (42%), Positives = 105/181 (58%), Gaps = 2/181 (1%) Frame = +3 Query: 15 GDDGKITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDL 194 G I+ F+ T +L +I++ S + I+ +ML LQGL Y+H+ HRDL Sbjct: 88 GHKSNISLVFDFMET---DLEVIIKDTSLVLTPAHIKSYMLMTLQGLEYLHHLWILHRDL 144 Query: 195 KPENLLVS-NGIVKIADFGLAREVCSTPP-YTDYVSTRWYRAPEVLLQASAYTPSIDMWA 368 KP NLL+ NG++K+ADFGLA+ S YT V TRWYR+PE+L A Y +DMWA Sbjct: 145 KPNNLLLDENGVLKLADFGLAKSFGSPNRIYTHQVVTRWYRSPELLFGARMYGVGVDMWA 204 Query: 369 IGAILAELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRN 548 +G ILAEL P PG+++ DQL +I LGTP WP +LP +F+ F P + Sbjct: 205 VGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPGMSSLPDYVAFKSFPGTPLH 264 Query: 549 L 551 L Sbjct: 265 L 265
>CDC22_ORYSA (P29619) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 292 Score = 138 bits (348), Expect = 1e-32 Identities = 70/165 (42%), Positives = 103/165 (62%), Gaps = 3/165 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN--GIVKIADFGLAREV-CSTPPYTDY 290 ++ F+ QIL+G+ Y H++ HRDLKP+NLL+ +K+ADFGLAR +T Sbjct: 103 VKSFLYQILRGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTHE 162 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAPE+LL A Y+ +DMW++G I AE+ PLFPG++E D+LFKI +++GTP Sbjct: 163 VVTLWYRAPEILLGARHYSTPVDMWSVGCIFAEMVNQKPLFPGDSEIDELFKIFSIMGTP 222 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + WP +LP S F + P +L ++P LDL+ ++ Sbjct: 223 NEETWPGVASLPDYIS-TFPKWPSVDLATVVPTLDSSGLDLLSKM 266
>IME2_YEAST (P32581) Meiosis induction protein kinase IME2/SME1 (EC 2.7.11.1)| Length = 645 Score = 137 bits (345), Expect = 2e-32 Identities = 77/218 (35%), Positives = 118/218 (54%), Gaps = 36/218 (16%) Frame = +3 Query: 69 NLYDVIRERSAP-FSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS--------- 218 NLY +++ R FS ++ + QIL GL ++H + +FHRDLKPEN+L++ Sbjct: 152 NLYQMMKHRRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKE 211 Query: 219 ---------NGIVKIADFGLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAI 371 N ++K+ADFGLAR V + PYT YVSTRWYR+PE+LL++ Y+ +D+WA Sbjct: 212 YMNQIGYQDNYVIKLADFGLARHVENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAF 271 Query: 372 GAILAELFTLSPLFPGETETDQLFKICAVLGTP---------DH-------SLWPEGMNL 503 G + E+ LFPG E DQ++KI VLGTP +H W + NL Sbjct: 272 GCVAVEVTVFRALFPGANEIDQIWKILEVLGTPIKRSDFVNTNHITAPPPGGFWDDASNL 331 Query: 504 PRSSSFQFFQIPPRNLWELIPNASLEAL-DLIKQLCSW 614 + + + +L L+ ++ L L +++K+ W Sbjct: 332 VHKLNLKLPYVEGSSLDHLLSSSQLSDLSEVVKKCLRW 369
>CDC2_CHERU (P93101) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 137 bits (345), Expect = 2e-32 Identities = 72/167 (43%), Positives = 104/167 (62%), Gaps = 4/167 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN--GIVKIADFGLAREV-CSTPPYTDY 290 I++F+ QIL+G+ Y H++ HRDLKP+NLL+ +K+ADFGLAR +T Sbjct: 104 IKRFLYQILRGIAYCHSHRVLHRDLKPQNLLIDRQTNALKLADFGLARAFGIPVRTFTHE 163 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAPE+LL + Y+ +D+W++G I AE+ PLFPG++E D+LFKI LGTP Sbjct: 164 VVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRTLGTP 223 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLI-KQLC 608 + WP +LP S F + ++L ++PN +DL+ K LC Sbjct: 224 NEETWPGVTSLPDFKS-SFPKWISKDLSAVVPNLDPAGIDLLNKMLC 269
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 137 bits (345), Expect = 2e-32 Identities = 72/164 (43%), Positives = 105/164 (64%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QILQG+V+ H+ HRDLKP+NLL+ + G +K+ADFGLAR YT V Sbjct: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR+PEVLL ++ Y+ +D+W+IG I AEL T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WPE +L + F + P +L + N LDL+ ++ Sbjct: 225 NEVWPEVESL-QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKM 267
>CDC2_PONPY (Q5RCH1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 137 bits (345), Expect = 2e-32 Identities = 72/164 (43%), Positives = 105/164 (64%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QILQG+V+ H+ HRDLKP+NLL+ + G +K+ADFGLAR YT V Sbjct: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR+PEVLL ++ Y+ +D+W+IG I AEL T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WPE +L + F + P +L + N LDL+ ++ Sbjct: 225 NEVWPEVESL-QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKM 267
>CDC2_HUMAN (P06493) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 137 bits (345), Expect = 2e-32 Identities = 72/164 (43%), Positives = 105/164 (64%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QILQG+V+ H+ HRDLKP+NLL+ + G +K+ADFGLAR YT V Sbjct: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR+PEVLL ++ Y+ +D+W+IG I AEL T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WPE +L + F + P +L + N LDL+ ++ Sbjct: 225 NEVWPEVESL-QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKM 267
>MMK1_MEDSA (Q07176) Mitogen-activated protein kinase homolog MMK1 (EC| 2.7.11.24) (MAP kinase MSK7) (MAP kinase ERK1) Length = 387 Score = 137 bits (344), Expect = 3e-32 Identities = 76/187 (40%), Positives = 114/187 (60%), Gaps = 5/187 (2%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L+ +IR A SEE + F+ QIL+GL Y+H+ HRDLKP NLL++ N +KI DF Sbjct: 142 DLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDF 200 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLAR T T+YV TRWYRAPE+LL +S YT +ID+W++G I EL PLFPG Sbjct: 201 GLARVTSETDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD 260 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFF-QIPP---RNLWELIPNASLEALDL 593 QL + ++GTP + + ++ ++ Q+PP ++ E P+ EA+DL Sbjct: 261 HVHQLRLLMELIGTPSE----DDLGFLNENAKRYIRQLPPYRRQSFQEKFPHVHPEAIDL 316 Query: 594 IKQLCSW 614 ++++ ++ Sbjct: 317 VEKMLTF 323
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 137 bits (344), Expect = 3e-32 Identities = 72/164 (43%), Positives = 105/164 (64%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QILQG+V+ H+ HRDLKP+NLL+ S G++K+ADFGLAR YT V Sbjct: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDSKGVIKLADFGLARAFGIPVRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPEVLL + Y+ +D+W+IG I AE+ T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIATKKPLFHGDSEIDQLFRIFRALGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WPE +L + F + +L + N + LDL+ ++ Sbjct: 225 NEVWPEVESL-QDYKNSFPKWKGGSLSANVKNIDKDGLDLLAKM 267
>CDK4_RAT (P35426) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) Length = 303 Score = 137 bits (344), Expect = 3e-32 Identities = 76/168 (45%), Positives = 101/168 (60%), Gaps = 1/168 (0%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLAREVCSTPPYTDY 290 E I+ M Q L GL ++H N HRDLKPEN+LV SNG VK+ADFGLAR T Sbjct: 115 ETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPV 174 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAPEVLLQ++ TP +DMW++G I AE+F PLF G +E DQL KI ++G P Sbjct: 175 VVTLWYRAPEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 WP ++LPR + F PR + ++P L+ ++ ++ Sbjct: 234 PEDDWPREVSLPRGA---FSPRGPRPVQSVVPEMEESGAQLLLEMLTF 278
>CDK4_MOUSE (P30285) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) (CRK3) Length = 303 Score = 137 bits (344), Expect = 3e-32 Identities = 76/168 (45%), Positives = 101/168 (60%), Gaps = 1/168 (0%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLAREVCSTPPYTDY 290 E I+ M Q L GL ++H N HRDLKPEN+LV SNG VK+ADFGLAR T Sbjct: 115 ETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPV 174 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAPEVLLQ++ TP +DMW++G I AE+F PLF G +E DQL KI ++G P Sbjct: 175 VVTLWYRAPEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 WP ++LPR + F PR + ++P L+ ++ ++ Sbjct: 234 PEDDWPREVSLPRGA---FAPRGPRPVQSVVPEMEESGAQLLLEMLTF 278
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 137 bits (344), Expect = 3e-32 Identities = 70/164 (42%), Positives = 103/164 (62%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QIL+G+ + H HRDLKP+NLL+ N G++K+ADFGLAR YT V Sbjct: 105 VKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPEVLL + Y+ +D+W+ G I AEL T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WP+ +LP + F + +L ++ N LDL+ ++ Sbjct: 225 NDVWPDVESLPDYKN-TFPKWKEGSLSSMVKNLDKNGLDLLAKM 267
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 136 bits (343), Expect = 4e-32 Identities = 70/164 (42%), Positives = 103/164 (62%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QIL+G+ + H HRDLKP+NLL+ N G++K+ADFGLAR YT V Sbjct: 105 VKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPEVLL + Y+ +D+W+ G I AEL T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WP+ +LP + F + +L ++ N LDL+ ++ Sbjct: 225 NDVWPDVESLPDYKN-TFPKWKGGSLSSMVKNLDKNGLDLLAKM 267
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 136 bits (343), Expect = 4e-32 Identities = 70/164 (42%), Positives = 103/164 (62%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QIL+G+ + H HRDLKP+NLL+ N G++K+ADFGLAR YT V Sbjct: 105 VKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPEVLL + Y+ +D+W+ G I AEL T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WP+ +LP + F + +L ++ N LDL+ ++ Sbjct: 225 NDVWPDVESLPDYKN-TFPKWMEGSLSSMVKNLDKNGLDLLAKM 267
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 136 bits (343), Expect = 4e-32 Identities = 70/164 (42%), Positives = 103/164 (62%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QIL+G+ + H HRDLKP+NLL+ N G++K+ADFGL+R YT V Sbjct: 105 VKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLSRAFGVPVRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPEVLL + Y+ +D+W+ G I AEL T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WP+ +LP S F + +L ++ N LDL+ ++ Sbjct: 225 NDVWPDVESLPDYKS-TFPKWKGGSLSSMVKNLDKNGLDLLAKM 267
>CDC2_SCHPO (P04551) Cell division control protein 2 (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinse) Length = 297 Score = 136 bits (343), Expect = 4e-32 Identities = 68/164 (41%), Positives = 105/164 (64%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++KF Q++ G+ + H+ HRDLKP+NLL+ G +K+ADFGLAR YT + Sbjct: 111 VQKFTYQLVNGVNFCHSRRIIHRDLKPQNLLIDKEGNLKLADFGLARSFGVPLRNYTHEI 170 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPEVLL + Y+ +D+W++G I AE+ SPLFPG++E D++FKI VLGTP+ Sbjct: 171 VTLWYRAPEVLLGSRHYSTGVDIWSVGCIFAEMIRRSPLFPGDSEIDEIFKIFQVLGTPN 230 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 +WP G+ L + F + +L +++PN +A++L+ + Sbjct: 231 EEVWP-GVTLLQDYKSTFPRWKRMDLHKVVPNGEEDAIELLSAM 273
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 136 bits (343), Expect = 4e-32 Identities = 72/164 (43%), Positives = 105/164 (64%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QILQG+V+ H+ HRDLKP+NLL+ + G +K+ADFGLAR YT V Sbjct: 105 VKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR+PEVLL ++ Y+ +D+W+IG I AEL T PLF G++E DQLF+I LGTP+ Sbjct: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WPE +L + F + P +L + N LDL+ ++ Sbjct: 225 NEVWPEVESL-QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKM 267
>BUR1_EMENI (Q96VK3) Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC| 2.7.11.23) (Pitalre-like kinase A) Length = 544 Score = 136 bits (343), Expect = 4e-32 Identities = 74/192 (38%), Positives = 107/192 (55%), Gaps = 13/192 (6%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ FSE +I+ +M+Q+L+GL Y+H N HRD+K NLL+SN GI++IADF Sbjct: 115 DLSGLLENPEVHFSEAQIKCYMIQLLEGLKYLHGNCILHRDMKAANLLISNQGILQIADF 174 Query: 246 GLAREVCSTPP------------YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAE 389 GLAR PP YT V TRWYR PE+LLQ YT +IDMW +G + E Sbjct: 175 GLARPFDEAPPQPGKGAGEAKRDYTTLVVTRWYRPPELLLQLRRYTSAIDMWGVGCVFGE 234 Query: 390 LFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPN 569 +F P+ G ++ +Q I +++GTP P +LP + F P NL E+ + Sbjct: 235 MFKGKPILAGNSDLNQAQLIFSLVGTPTEENMPGWSSLPGCEGVKHFGNRPGNLAEVFKD 294 Query: 570 ASLEALDLIKQL 605 A+ L+ +L Sbjct: 295 QGPMAISLLTEL 306
>MPK5_ARATH (Q39025) Mitogen-activated protein kinase homolog 5 (EC 2.7.11.24)| (MAP kinase 5) (AtMPK5) Length = 376 Score = 136 bits (342), Expect = 6e-32 Identities = 74/185 (40%), Positives = 115/185 (62%), Gaps = 6/185 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADF 245 +L+ +IR + +++ + F+ QIL+GL Y+H+ HRDLKP NLL+ SN +KI DF Sbjct: 130 DLHQIIRSNQS-LNDDHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNSNCDLKITDF 188 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLAR T T+YV TRWYRAPE+LL +S YT +ID+W++G I AE+ T PLFPG+ Sbjct: 189 GLARTTSETEYMTEYVVTRWYRAPELLLNSSEYTSAIDVWSVGCIFAEIMTREPLFPGKD 248 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFF-----QIPPRNLWELIPNASLEALD 590 QL I ++G+PD + + RS++ + + + P +N P+ + A+D Sbjct: 249 YVHQLKLITELIGSPDGA----SLEFLRSANARKYVKELPKFPRQNFSARFPSMNSTAID 304 Query: 591 LIKQL 605 L++++ Sbjct: 305 LLEKM 309
>CDC2H_THEPA (Q27032) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 135 bits (341), Expect = 7e-32 Identities = 68/165 (41%), Positives = 106/165 (64%), Gaps = 4/165 (2%) Frame = +3 Query: 123 RKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREVC-STPPYTDYVS 296 + F+ QIL+G+ Y H++ HRDLKP+NLL++ G++K+ADFGLAR YT V Sbjct: 103 KSFLYQILRGISYCHDHRILHRDLKPQNLLINREGVLKLADFGLARAFAIPVRSYTHEVV 162 Query: 297 TRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDH 476 T WYRAP+VL+ + Y+ ++D+W++G I AE+ PLFPG +E DQL +I +LGTP Sbjct: 163 TLWYRAPDVLMGSKKYSTAVDIWSVGCIFAEMINGVPLFPGISEQDQLKRIFKILGTPSV 222 Query: 477 SLWPEGMNLPR-SSSFQFFQIPPRNLW-ELIPNASLEALDLIKQL 605 WP+ +NLP + F +++ + W ++P + +DLI ++ Sbjct: 223 DSWPQVVNLPAYNPDFSYYE---KQSWSSIVPKLNESGIDLISRM 264
>SLT2_YEAST (Q00772) Mitogen-activated protein kinase SLT2/MPK1 (EC 2.7.11.24)| (MAP kinase MPK1) Length = 484 Score = 135 bits (341), Expect = 7e-32 Identities = 81/205 (39%), Positives = 114/205 (55%), Gaps = 7/205 (3%) Frame = +3 Query: 21 DGKITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKP 200 DG I + C+++ +I+ P ++ + F QIL GL Y+H+ HRDLKP Sbjct: 98 DGSINGLYLYEELMECDMHQIIKS-GQPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKP 156 Query: 201 ENLLVSNGI-VKIADFGLAREVCSTPP-----YTDYVSTRWYRAPEVLLQASAYTPSIDM 362 NLLV+ +KI DFGLAR P T+YV+TRWYRAPE++L YT +ID+ Sbjct: 157 GNLLVNADCQLKICDFGLARGYSENPVENSQFLTEYVATRWYRAPEIMLSYQGYTKAIDV 216 Query: 363 WAIGAILAELFTLSPLFPGETETDQLFKICAVLGT-PDHSLWPEGMNLPRSSSFQFFQIP 539 W+ G ILAE P+F G+ +QL +I VLGT PD +L G + Q IP Sbjct: 217 WSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDETLRRIGSKNVQDYIHQLGFIP 276 Query: 540 PRNLWELIPNASLEALDLIKQLCSW 614 L PNA+ +ALDL++Q+ ++ Sbjct: 277 KVPFVNLYPNANSQALDLLEQMLAF 301
>CD2L7_HUMAN (Q9NYV4) Cell division cycle 2-related protein kinase 7 (EC| 2.7.11.22) (CDC2-related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) Length = 1490 Score = 135 bits (341), Expect = 7e-32 Identities = 74/168 (44%), Positives = 106/168 (63%), Gaps = 6/168 (3%) Frame = +3 Query: 105 FSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREVCS--TP 275 FSE+ I+ FM Q+++GL Y H + HRD+K N+L++N G +K+ADFGLAR S + Sbjct: 831 FSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESR 890 Query: 276 PYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICA 455 PYT+ V T WYR PE+LL YTP+ID+W+ G IL ELFT P+F E QL I Sbjct: 891 PYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISR 950 Query: 456 VLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWE---LIPNASLEALD 590 + G+P ++WP+ + LP ++ + + R L E IP+A+L+ LD Sbjct: 951 LCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLD 998
>CDC21_ORYSA (P29618) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 294 Score = 135 bits (341), Expect = 7e-32 Identities = 70/165 (42%), Positives = 102/165 (61%), Gaps = 3/165 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN--GIVKIADFGLAREV-CSTPPYTDY 290 I+ ++ QIL+G+ Y H++ HRDLKP+NLL+ +K+ADFGLAR +T Sbjct: 104 IKSYLYQILRGVAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPVRTFTHE 163 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAPE+LL + Y+ +DMW++G I AE+ PLFPG++E D+LFKI VLGTP Sbjct: 164 VVTLWYRAPEILLGSRQYSTPVDMWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRVLGTP 223 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + WP +LP S F + ++L ++P LDL+ ++ Sbjct: 224 NEQSWPGVSSLPDYKS-AFPKWQAQDLATIVPTLDPAGLDLLSKM 267
>CDC2H_THEAN (Q26671) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 298 Score = 135 bits (340), Expect = 9e-32 Identities = 68/165 (41%), Positives = 107/165 (64%), Gaps = 4/165 (2%) Frame = +3 Query: 123 RKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREVC-STPPYTDYVS 296 + F+ QIL+G+ Y H++ HRDLKP+NLL++ G++K+ADFGLAR YT V Sbjct: 103 KSFLYQILRGISYCHDHRILHRDLKPQNLLINREGVLKLADFGLARAFAIPVRSYTHEVV 162 Query: 297 TRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDH 476 T WYRAP+VL+ + Y+ ++D+W++G I AE+ PLFPG +E DQL +I +LGTP+ Sbjct: 163 TLWYRAPDVLMGSKKYSTAVDIWSVGCIFAEMINGVPLFPGISEQDQLKRIFKILGTPNV 222 Query: 477 SLWPEGMNLPR-SSSFQFFQIPPRNLW-ELIPNASLEALDLIKQL 605 WP+ +NLP + F +++ + W ++P + +DLI ++ Sbjct: 223 DSWPQVVNLPAYNPDFCYYE---KQAWSSIVPKLNESGIDLISRM 264
>CDK4_PIG (P79432) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 303 Score = 135 bits (340), Expect = 9e-32 Identities = 75/168 (44%), Positives = 101/168 (60%), Gaps = 1/168 (0%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLAREVCSTPPYTDY 290 E I+ M Q L+GL ++H N HRDLKPEN+LV S G VK+ADFGLAR T Sbjct: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPV 174 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAPEVLLQ++ TP +DMW++G I AE+F PLF G +E DQL KI ++G P Sbjct: 175 VVTLWYRAPEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 WP ++LPR + F PR + ++P L+ ++ ++ Sbjct: 234 PEDDWPRDVSLPRGA---FSPRGPRPVQSVVPEMEESGAQLLLEMLTF 278
>MK07_HUMAN (Q13164) Mitogen-activated protein kinase 7 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase) Length = 815 Score = 135 bits (340), Expect = 9e-32 Identities = 80/203 (39%), Positives = 119/203 (58%), Gaps = 9/203 (4%) Frame = +3 Query: 24 GKITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPE 203 G+ S L+ +L+ +I S P + E +R F+ Q+L+GL YMH+ HRDLKP Sbjct: 127 GEFKSVYVVLDLMESDLHQIIHS-SQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPS 185 Query: 204 NLLVS-NGIVKIADFGLAREVCSTPP-----YTDYVSTRWYRAPEVLLQASAYTPSIDMW 365 NLLV+ N +KI DFG+AR +C++P T+YV+TRWYRAPE++L YT +ID+W Sbjct: 186 NLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLW 245 Query: 366 AIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPR 545 ++G I E+ LFPG+ QL I VLGTP ++ + + R ++ +PPR Sbjct: 246 SVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV-IQAVGAERVRAY-IQSLPPR 303 Query: 546 N--LWELI-PNASLEALDLIKQL 605 WE + P A +AL L+ ++ Sbjct: 304 QPVPWETVYPGADRQALSLLGRM 326
>MK07_MOUSE (Q9WVS8) Mitogen-activated protein kinase 7 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase) Length = 806 Score = 135 bits (340), Expect = 9e-32 Identities = 80/203 (39%), Positives = 119/203 (58%), Gaps = 9/203 (4%) Frame = +3 Query: 24 GKITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPE 203 G+ S L+ +L+ +I S P + E +R F+ Q+L+GL YMH+ HRDLKP Sbjct: 128 GEFRSVYVVLDLMESDLHQIIHS-SQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPS 186 Query: 204 NLLVS-NGIVKIADFGLAREVCSTPP-----YTDYVSTRWYRAPEVLLQASAYTPSIDMW 365 NLLV+ N +KI DFG+AR +C++P T+YV+TRWYRAPE++L YT +ID+W Sbjct: 187 NLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLW 246 Query: 366 AIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPR 545 ++G I E+ LFPG+ QL I VLGTP ++ + + R ++ +PPR Sbjct: 247 SVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV-IQAVGAERVRAY-IQSLPPR 304 Query: 546 N--LWELI-PNASLEALDLIKQL 605 WE + P A +AL L+ ++ Sbjct: 305 QPVPWETVYPGADRQALSLLGRM 327
>BUR1_ASPFU (Q4WTN5) Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 580 Score = 135 bits (339), Expect = 1e-31 Identities = 72/192 (37%), Positives = 109/192 (56%), Gaps = 13/192 (6%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ + F+E +I+ +MLQ+L+GL Y+H N HRD+K NLL+SN G+++IADF Sbjct: 115 DLSGLLENPAVNFTEPQIKCYMLQLLEGLKYLHGNRILHRDMKAANLLISNNGVLQIADF 174 Query: 246 GLAREVCSTPP------------YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAE 389 GLAR PP YT V TRWYR PE+LLQ YT +IDMW +G + E Sbjct: 175 GLARPYDEPPPEPGKGGGEAKRDYTTLVVTRWYRPPELLLQLRRYTTAIDMWGVGCVFGE 234 Query: 390 LFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPN 569 +F P+ G ++ +Q I ++GTP P +LP + F P +L E+ + Sbjct: 235 MFKGKPILAGSSDLNQTQLIFNLVGTPTEENMPGWSSLPGCEGVKSFGYKPGSLREVFKD 294 Query: 570 ASLEALDLIKQL 605 + A+ L+++L Sbjct: 295 QNPMAISLLEEL 306
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 134 bits (338), Expect = 2e-31 Identities = 70/164 (42%), Positives = 105/164 (64%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ FM Q+L+G+++ H+N HRDLKP+NLL++N G +K+ DFGLAR +++ V Sbjct: 108 VKSFMFQLLKGIMFCHDNRVLHRDLKPQNLLINNKGELKLGDFGLARAFGIPFNTFSNEV 167 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAP+VLL + AYT SID+W+ G I AE+ T PLFPG DQL KI ++GTP+ Sbjct: 168 VTLWYRAPDVLLGSRAYTTSIDIWSAGCIFAEMCTGKPLFPGTANEDQLIKIFRLMGTPN 227 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 WP G++ + + P++L ++PN L+L++ L Sbjct: 228 ERTWP-GISQYTNYKNNWQIFVPQDLRLIVPNLDSMGLNLLQSL 270
>CDK4_HUMAN (P11802) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) Length = 303 Score = 134 bits (338), Expect = 2e-31 Identities = 75/168 (44%), Positives = 101/168 (60%), Gaps = 1/168 (0%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLAREVCSTPPYTDY 290 E I+ M Q L+GL ++H N HRDLKPEN+LV S G VK+ADFGLAR T Sbjct: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPV 174 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAPEVLLQ++ TP +DMW++G I AE+F PLF G +E DQL KI ++G P Sbjct: 175 VVTLWYRAPEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 WP ++LPR + F PR + ++P L+ ++ ++ Sbjct: 234 PEDDWPRDVSLPRGA---FPPRGPRPVQSVVPEMEESGAQLLLEMLTF 278
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 134 bits (338), Expect = 2e-31 Identities = 72/165 (43%), Positives = 106/165 (64%), Gaps = 3/165 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ F+ Q+L+G+++ H+N HRDLKP+NLL++N G +K+ DFGLAR +++ V Sbjct: 108 VKSFIFQLLKGIMFCHDNRVLHRDLKPQNLLINNKGELKLGDFGLARAFGIPFNTFSNEV 167 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAP+VLL + AYT SID+W+ G I AE+ T PLFPG + DQL KI ++GTP+ Sbjct: 168 VTLWYRAPDVLLGSRAYTASIDIWSAGCIFAEMCTGKPLFPGTSNDDQLIKIFRLMGTPN 227 Query: 474 HSLWPEGMNLPR-SSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 WP + +++Q F P++L LIPN L+L+ L Sbjct: 228 ERTWPGVSSYANFKNNWQIF--VPQDLRLLIPNLDSMGLNLLSSL 270
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 134 bits (338), Expect = 2e-31 Identities = 68/167 (40%), Positives = 104/167 (62%), Gaps = 2/167 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ Q+LQGL + H++ HRDLKP+NLL+ S+G +K+ADFGLAR +T V Sbjct: 104 VKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSDGAIKLADFGLARAFGVPVRTFTHEV 163 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPE+LL Y+ ++D+W++G I AE+ T LFPG++E DQLF+I LGTPD Sbjct: 164 VTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPD 223 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 WP +P S F + ++ +++P + DL+ Q+ + Sbjct: 224 EVSWPGVTTMPDYKS-TFPKWIRQDFSKVVPPLDEDGRDLLAQMLQY 269
>CDK2_HUMAN (P24941) Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein| kinase) Length = 298 Score = 134 bits (336), Expect = 3e-31 Identities = 63/131 (48%), Positives = 89/131 (67%), Gaps = 2/131 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 I+ ++ Q+LQGL + H++ HRDLKP+NLL++ G +K+ADFGLAR YT V Sbjct: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV 163 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPE+LL Y+ ++D+W++G I AE+ T LFPG++E DQLF+I LGTPD Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 Query: 474 HSLWPEGMNLP 506 +WP ++P Sbjct: 224 EVVWPGVTSMP 234
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 134 bits (336), Expect = 3e-31 Identities = 63/131 (48%), Positives = 90/131 (68%), Gaps = 2/131 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTDYV 293 I+ ++ Q+LQGL + H++ HRDLKP+NLL++ +G +K+ADFGLAR YT V Sbjct: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINADGSIKLADFGLARAFGVPVRTYTHEV 163 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPE+LL Y+ ++D+W++G I AE+ T LFPG++E DQLF+I LGTPD Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 Query: 474 HSLWPEGMNLP 506 +WP ++P Sbjct: 224 EVVWPGVTSMP 234
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 134 bits (336), Expect = 3e-31 Identities = 70/159 (44%), Positives = 100/159 (62%), Gaps = 2/159 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ F Q+LQGL + H N HRDLKP+NLL++ G +K+ DFGLAR ++ V Sbjct: 110 VKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV 169 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAP+VL+ + Y+ SID+W+ G ILAE+ T PLFPG + +QL I ++GTP+ Sbjct: 170 VTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPN 229 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALD 590 SLWP LP+ + Q PPR+L +++ + E LD Sbjct: 230 ESLWPSVTKLPKYNP-NIQQRPPRDLRQVLQPHTKEPLD 267
>CDC2_MAIZE (P23111) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 134 bits (336), Expect = 3e-31 Identities = 69/165 (41%), Positives = 101/165 (61%), Gaps = 3/165 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN--GIVKIADFGLAREV-CSTPPYTDY 290 I+ ++ QIL G+ Y H++ HRDLKP+NLL+ +K+ADFGLAR +T Sbjct: 104 IKSYLYQILHGVAYCHSHRVLHRDLKPQNLLIDRRTNALKLADFGLARAFGIPVRTFTHE 163 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAPE+LL A Y+ +D+W++G I AE+ PLFPG++E D+LFKI +LGTP Sbjct: 164 VVTLWYRAPEILLGARQYSTPVDVWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRILGTP 223 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + WP LP + F + ++L ++PN LDL+ ++ Sbjct: 224 NEQSWPGVSCLPDFKT-AFPRWQAQDLATVVPNLDPAGLDLLSKM 267
>MAPK_PEA (Q06060) Mitogen-activated protein kinase homolog D5 (EC 2.7.11.24)| Length = 394 Score = 133 bits (335), Expect = 4e-31 Identities = 76/186 (40%), Positives = 112/186 (60%), Gaps = 4/186 (2%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L+ +IR A SEE + F+ QIL+GL Y+H+ HRDLKP NLL++ N +KI DF Sbjct: 149 DLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDF 207 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLAR T T+YV TRWYRAPE+LL +S YT +ID+W++G I EL PLFPG Sbjct: 208 GLARVTSETDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD 267 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIP---PRNLWELIPNASLEALDLI 596 QL + ++GTP + + L ++ Q+P ++ E P+ EA+DL+ Sbjct: 268 HVHQLRLLMELIGTPSEA---DLGFLNENAKRYIRQLPLYRRQSFQEKFPHVHPEAIDLV 324 Query: 597 KQLCSW 614 +++ ++ Sbjct: 325 EKMLTF 330
>CDK2_RAT (Q63699) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 133 bits (335), Expect = 4e-31 Identities = 63/131 (48%), Positives = 89/131 (67%), Gaps = 2/131 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTDYV 293 I+ ++ Q+LQGL + H++ HRDLKP+NLL++ G +K+ADFGLAR YT V Sbjct: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEV 163 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPE+LL Y+ ++D+W++G I AE+ T LFPG++E DQLF+I LGTPD Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 Query: 474 HSLWPEGMNLP 506 +WP ++P Sbjct: 224 EVVWPGVTSMP 234
>CDK2_MESAU (P48963) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 133 bits (335), Expect = 4e-31 Identities = 63/131 (48%), Positives = 89/131 (67%), Gaps = 2/131 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTDYV 293 I+ ++ Q+LQGL + H++ HRDLKP+NLL++ G +K+ADFGLAR YT V Sbjct: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEV 163 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPE+LL Y+ ++D+W++G I AE+ T LFPG++E DQLF+I LGTPD Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 Query: 474 HSLWPEGMNLP 506 +WP ++P Sbjct: 224 EVVWPGVTSMP 234
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 133 bits (335), Expect = 4e-31 Identities = 63/131 (48%), Positives = 89/131 (67%), Gaps = 2/131 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTDYV 293 I+ ++ Q+LQGL + H++ HRDLKP+NLL++ G +K+ADFGLAR YT V Sbjct: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEV 163 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPE+LL Y+ ++D+W++G I AE+ T LFPG++E DQLF+I LGTPD Sbjct: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 Query: 474 HSLWPEGMNLP 506 +WP ++P Sbjct: 224 EVVWPGVTSMP 234
>CDC2A_ARATH (P24100) Cell division control protein 2 homolog A (EC 2.7.11.22)| (EC 2.7.11.23) Length = 294 Score = 133 bits (335), Expect = 4e-31 Identities = 68/165 (41%), Positives = 102/165 (61%), Gaps = 3/165 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN--GIVKIADFGLAREV-CSTPPYTDY 290 I+ ++ QIL+G+ Y H++ HRDLKP+NLL+ +K+ADFGLAR +T Sbjct: 104 IKTYLYQILRGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTHE 163 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAPE+LL + Y+ +D+W++G I AE+ + PLFPG++E DQLFKI ++GTP Sbjct: 164 VVTLWYRAPEILLGSHHYSTPVDIWSVGCIFAEMISQKPLFPGDSEIDQLFKIFRIMGTP 223 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 W +LP S F + P +L +PN + +DL+ ++ Sbjct: 224 YEDTWRGVTSLPDYKS-AFPKWKPTDLETFVPNLDPDGVDLLSKM 267
>CDC21_MEDSA (P24923) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (Fragment) Length = 291 Score = 133 bits (335), Expect = 4e-31 Identities = 68/166 (40%), Positives = 102/166 (61%), Gaps = 3/166 (1%) Frame = +3 Query: 117 EIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN--GIVKIADFGLAREV-CSTPPYTD 287 +++ F+ Q+L G+ Y H++ HRDLKP+NLL+ +K+ADFGLAR +T Sbjct: 100 QVKMFLYQMLCGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTH 159 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGT 467 V T WYRAPE+LL + Y+ +D+W++G I AE+ PL PG++E D+LFKI +LGT Sbjct: 160 EVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMANRRPLSPGDSEIDELFKIFRILGT 219 Query: 468 PDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 P+ WP +LP S F + P ++L ++PN LDL+ + Sbjct: 220 PNEDTWPGVTSLPDFKS-TFPRWPSKDLATVVPNLEPAGLDLLNSM 264
>MPK6_ARATH (Q39026) Mitogen-activated protein kinase homolog 6 (EC 2.7.11.24)| (MAP kinase 6) (AtMPK6) Length = 395 Score = 133 bits (334), Expect = 5e-31 Identities = 76/186 (40%), Positives = 111/186 (59%), Gaps = 4/186 (2%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L+ +IR A SEE + F+ QIL+GL Y+H+ HRDLKP NLL++ N +KI DF Sbjct: 150 DLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDF 208 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLAR + T+YV TRWYRAPE+LL +S YT +ID+W++G I EL PLFPG Sbjct: 209 GLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD 268 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPP---RNLWELIPNASLEALDLI 596 QL + ++GTP E L ++ Q+PP +++ + P A+DLI Sbjct: 269 HVHQLRLLMELIGTPSEE---ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLI 325 Query: 597 KQLCSW 614 +++ ++ Sbjct: 326 EKMLTF 331
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 133 bits (334), Expect = 5e-31 Identities = 70/164 (42%), Positives = 104/164 (63%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLAREV-CSTPPYTDYV 293 ++ ++ QILQG+++ H HRDLKP+NLL+ S G++K+ADFGLAR YT V Sbjct: 105 VKSYLYQILQGIIFCHARRVLHRDLKPQNLLIDSKGVIKLADFGLARAFGIPVRVYTHEV 164 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAPEVLL + Y+ +D+W+IG I AE+ + PLF G++E DQLF+I + GTP+ Sbjct: 165 VTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIASKKPLFHGDSEIDQLFRISELWGTPN 224 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WPE +L + F + +L + N E LDL+ ++ Sbjct: 225 NEVWPEVESL-QDYKNTFPKWKGGSLAANVKNIDKEGLDLLAKM 267
>CD2L5_MOUSE (Q69ZA1) Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22)| (CDC2-related protein kinase 5) Length = 1511 Score = 132 bits (333), Expect = 6e-31 Identities = 73/173 (42%), Positives = 105/173 (60%), Gaps = 6/173 (3%) Frame = +3 Query: 105 FSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREVCS--TP 275 F+E I+ FM Q+++GL Y H + HRD+K N+L++N G +K+ADFGLAR S + Sbjct: 809 FNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESR 868 Query: 276 PYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICA 455 PYT+ V T WYR PE+LL YTP+ID+W+ G IL ELFT P+F E QL I Sbjct: 869 PYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISR 928 Query: 456 VLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWE---LIPNASLEALDLIKQL 605 + G+P ++WP+ + LP ++ + + R L E IP A+L+ D + L Sbjct: 929 ICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLAL 981
>CD2L5_HUMAN (Q14004) Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22)| (CDC2-related protein kinase 5) (Cholinesterase-related cell division controller) Length = 1512 Score = 132 bits (333), Expect = 6e-31 Identities = 73/173 (42%), Positives = 105/173 (60%), Gaps = 6/173 (3%) Frame = +3 Query: 105 FSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREVCS--TP 275 F+E I+ FM Q+++GL Y H + HRD+K N+L++N G +K+ADFGLAR S + Sbjct: 809 FNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESR 868 Query: 276 PYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICA 455 PYT+ V T WYR PE+LL YTP+ID+W+ G IL ELFT P+F E QL I Sbjct: 869 PYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISR 928 Query: 456 VLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWE---LIPNASLEALDLIKQL 605 + G+P ++WP+ + LP ++ + + R L E IP A+L+ D + L Sbjct: 929 ICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLAL 981
>CDK5_DROME (P48609) Cell division protein kinase 5 homolog (EC 2.7.11.22)| Length = 294 Score = 132 bits (333), Expect = 6e-31 Identities = 77/165 (46%), Positives = 100/165 (60%), Gaps = 4/165 (2%) Frame = +3 Query: 123 RKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTDYVS 296 R FMLQ+L+GL + H++ HRDLKP+NLL++ NG +K+ADFGLAR Y+ V Sbjct: 104 RSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVV 163 Query: 297 TRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLS-PLFPGETETDQLFKICAVLGTPD 473 T WYR P+VL A YT SIDMW+ G ILAEL PLFPG DQL KI VLGTP+ Sbjct: 164 TLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPN 223 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLW-ELIPNASLEALDLIKQL 605 WP +L + F P W +L+P + + DL+++L Sbjct: 224 EDSWPGVSHLSDYVALPSF--PAITSWSQLVPRLNSKGRDLLQKL 266
>ERKA_DROME (P40417) Mitogen-activated protein kinase ERK-A (EC 2.7.11.24)| (Extracellular-regulated kinase A) (Protein rolled) Length = 376 Score = 132 bits (332), Expect = 8e-31 Identities = 77/188 (40%), Positives = 112/188 (59%), Gaps = 6/188 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADF 245 +LY +++ + S + I F+ QIL+GL Y+H+ HRDLKP NLL++ +KI DF Sbjct: 124 DLYKLLKTQR--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDF 181 Query: 246 GLAR----EVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 GLAR E T T+YV+TRWYRAPE++L + YT SID+W++G ILAE+ + P+F Sbjct: 182 GLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 241 Query: 414 PGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLW-ELIPNASLEALD 590 PG+ DQL I VLG+P +N + + P W +L PNA ALD Sbjct: 242 PGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALD 301 Query: 591 LIKQLCSW 614 L+ ++ ++ Sbjct: 302 LLGKMLTF 309
>MK03_HUMAN (P27361) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) Length = 379 Score = 132 bits (332), Expect = 8e-31 Identities = 75/188 (39%), Positives = 113/188 (60%), Gaps = 6/188 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADF 245 +LY +++ S S + I F+ QIL+GL Y+H+ HRDLKP NLL++ +KI DF Sbjct: 128 DLYKLLK--SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDF 185 Query: 246 GLAR----EVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 GLAR E T T+YV+TRWYRAPE++L + YT SID+W++G ILAE+ + P+F Sbjct: 186 GLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 Query: 414 PGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLW-ELIPNASLEALD 590 PG+ DQL I +LG+P +N+ + Q + W +L P + +ALD Sbjct: 246 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALD 305 Query: 591 LIKQLCSW 614 L+ ++ ++ Sbjct: 306 LLDRMLTF 313
>MK03_RAT (P21708) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) (MNK1) Length = 380 Score = 132 bits (332), Expect = 8e-31 Identities = 75/188 (39%), Positives = 113/188 (60%), Gaps = 6/188 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADF 245 +LY +++ S S + I F+ QIL+GL Y+H+ HRDLKP NLL++ +KI DF Sbjct: 129 DLYKLLK--SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDF 186 Query: 246 GLAR----EVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 GLAR E T T+YV+TRWYRAPE++L + YT SID+W++G ILAE+ + P+F Sbjct: 187 GLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 246 Query: 414 PGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLW-ELIPNASLEALD 590 PG+ DQL I +LG+P +N+ + Q + W +L P + +ALD Sbjct: 247 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALD 306 Query: 591 LIKQLCSW 614 L+ ++ ++ Sbjct: 307 LLDRMLTF 314
>MK03_MOUSE (Q63844) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) (MNK1) Length = 380 Score = 132 bits (332), Expect = 8e-31 Identities = 75/188 (39%), Positives = 113/188 (60%), Gaps = 6/188 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADF 245 +LY +++ S S + I F+ QIL+GL Y+H+ HRDLKP NLL++ +KI DF Sbjct: 129 DLYKLLK--SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDF 186 Query: 246 GLAR----EVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 GLAR E T T+YV+TRWYRAPE++L + YT SID+W++G ILAE+ + P+F Sbjct: 187 GLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 246 Query: 414 PGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLW-ELIPNASLEALD 590 PG+ DQL I +LG+P +N+ + Q + W +L P + +ALD Sbjct: 247 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALD 306 Query: 591 LIKQLCSW 614 L+ ++ ++ Sbjct: 307 LLDRMLTF 314
>NTF4_TOBAC (Q40532) Mitogen-activated protein kinase homolog NTF4 (EC| 2.7.11.24) (P45) Length = 393 Score = 132 bits (331), Expect = 1e-30 Identities = 75/186 (40%), Positives = 111/186 (59%), Gaps = 4/186 (2%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L+ +IR SEE + F+ QIL+GL Y+H+ HRDLKP NLL++ N +KI DF Sbjct: 147 DLHQIIRSNQG-LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDF 205 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLAR T T+YV TRWYRAPE+LL +S YT +ID+W++G I EL PLFPG Sbjct: 206 GLARVTSETDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD 265 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIP---PRNLWELIPNASLEALDLI 596 QL + ++GTP + E L ++ Q+P ++ E P+ + A+DL+ Sbjct: 266 HVHQLRLLMELIGTPSEA---EMEFLNENAKRYIRQLPLYRRQSFVEKFPHVNPAAIDLV 322 Query: 597 KQLCSW 614 +++ ++ Sbjct: 323 EKMLTF 328
>CDC2H_PLAVI (Q9XZD6) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (Pvcrk2) Length = 288 Score = 132 bits (331), Expect = 1e-30 Identities = 64/131 (48%), Positives = 86/131 (65%), Gaps = 2/131 (1%) Frame = +3 Query: 123 RKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYVS 296 + F+LQ+L G+ Y H + HRDLKP+NLL++ G +KIADFGLAR YT V Sbjct: 103 KSFLLQLLSGIAYCHEHRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVV 162 Query: 297 TRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDH 476 T WYRAP++L+ + Y+ IDMW++G I AE+ PLFPG +ETDQL +I +LGTP+ Sbjct: 163 TLWYRAPDILMGSKKYSTPIDMWSVGCIFAEMVNGRPLFPGVSETDQLMRIFRILGTPNS 222 Query: 477 SLWPEGMNLPR 509 WP LP+ Sbjct: 223 ENWPNVTELPK 233
>CDK6_HUMAN (Q00534) Cell division protein kinase 6 (EC 2.7.11.22)| (Serine/threonine-protein kinase PLSTIRE) Length = 326 Score = 132 bits (331), Expect = 1e-30 Identities = 70/147 (47%), Positives = 94/147 (63%), Gaps = 1/147 (0%) Frame = +3 Query: 78 DVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLA 254 D + E P E I+ M Q+L+GL ++H++ HRDLKP+N+LV S+G +K+ADFGLA Sbjct: 110 DKVPEPGVP--TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA 167 Query: 255 REVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETD 434 R T V T WYRAPEVLLQ+S TP +D+W++G I AE+F PLF G ++ D Sbjct: 168 RIYSFQMALTSVVVTLWYRAPEVLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVD 226 Query: 435 QLFKICAVLGTPDHSLWPEGMNLPRSS 515 QL KI V+G P WP + LPR + Sbjct: 227 QLGKILDVIGLPGEEDWPRDVALPRQA 253
>CDC2H_PLAYO (Q7RM49) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 289 Score = 132 bits (331), Expect = 1e-30 Identities = 70/165 (42%), Positives = 101/165 (61%), Gaps = 4/165 (2%) Frame = +3 Query: 123 RKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYVS 296 + F+LQ+L G+ Y H + HRDLKP+NLL++ G +KIADFGLAR YT V Sbjct: 104 KSFLLQLLNGIAYCHEHRVLHRDLKPQNLLINREGELKIADFGLARAFGIPARRYTHEVV 163 Query: 297 TRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDH 476 T WYRAP++L+ + Y+ ID+W++G I AE+ PLFPG +ETDQL +I +LGTP+ Sbjct: 164 TLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGVSETDQLMRIFKILGTPNS 223 Query: 477 SLWPEGMNLPR-SSSFQFFQIPPRNLWE-LIPNASLEALDLIKQL 605 WP+ LP+ +F ++ P WE I +DL+ ++ Sbjct: 224 QNWPDVFKLPKYDPNFPVYEPLP---WETFIKGLDDTGIDLLSKM 265
>CDC2H_PLABA (Q4Z6R1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 131 bits (330), Expect = 1e-30 Identities = 63/131 (48%), Positives = 87/131 (66%), Gaps = 2/131 (1%) Frame = +3 Query: 123 RKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYVS 296 + F+LQ+L G+ Y H + HRDLKP+NLL++ G +KIADFGLAR YT V Sbjct: 103 KSFLLQLLNGIAYCHEHRVLHRDLKPQNLLINREGELKIADFGLARAFGIPARRYTHEVV 162 Query: 297 TRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDH 476 T WYRAP++L+ + Y+ ID+W++G I AE+ PLFPG +ETDQL +I +LGTP+ Sbjct: 163 TLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGASETDQLMRIFKILGTPNS 222 Query: 477 SLWPEGMNLPR 509 WP+ LP+ Sbjct: 223 QNWPDVFKLPK 233
>CDK6_MOUSE (Q64261) Cell division protein kinase 6 (EC 2.7.11.22)| (Serine/threonine-protein kinase PLSTIRE) (CRK2) Length = 326 Score = 131 bits (330), Expect = 1e-30 Identities = 69/147 (46%), Positives = 94/147 (63%), Gaps = 1/147 (0%) Frame = +3 Query: 78 DVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLA 254 D + E P E I+ M Q+L+GL ++H++ HRDLKP+N+LV S+G +K+ADFGLA Sbjct: 110 DKVPEPGVP--TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLA 167 Query: 255 REVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETD 434 R T V T WYRAPEVLLQ+S TP +D+W++G I AE+F PLF G ++ D Sbjct: 168 RIYSFQMALTSVVVTLWYRAPEVLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVD 226 Query: 435 QLFKICAVLGTPDHSLWPEGMNLPRSS 515 QL KI ++G P WP + LPR + Sbjct: 227 QLGKILDIIGLPGEEDWPRDVALPRQA 253
>PCTK3_MOUSE (Q04899) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 131 bits (330), Expect = 1e-30 Identities = 68/164 (41%), Positives = 99/164 (60%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAR-EVCSTPPYTDYV 293 ++ FM Q+L+GL Y H+ HRDLKP+NLL++ G +K+ADFGLAR + T Y++ V Sbjct: 219 VKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEV 278 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR P+VLL ++ Y+ IDMW +G IL E+ T PLFPG T ++L I +LGTP Sbjct: 279 VTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPLFPGSTVKEELHLIFRLLGTPT 338 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 WP ++ ++ F + P+ L P E ++L+ L Sbjct: 339 EESWPGVTSISEFRAYNFPRYLPQPLLSHAPRLDTEGINLLSSL 382
>KP58_DROME (Q9VPC0) Serine/threonine-protein kinase PITSLRE (EC 2.7.11.22) (Cell| division cycle 2-like) Length = 952 Score = 131 bits (330), Expect = 1e-30 Identities = 70/168 (41%), Positives = 101/168 (60%), Gaps = 7/168 (4%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L + ++ R F E++ Q+L+ + ++H+N HRDLK NLL+S+ GI+K+ DF Sbjct: 645 SLMETMKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDF 704 Query: 246 GLAREVCST-PPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGE 422 GLARE S YT V T WYRAPE+LL + Y+ ID+W++G I AE + PLFPG+ Sbjct: 705 GLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGK 764 Query: 423 TETDQLFKICAVLGTPDHSLWPEGMNLPR-----SSSFQFFQIPPRNL 551 +E D+L +I LGTP+ +WP LP S + QF + P L Sbjct: 765 SEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQL 812
>CDC2H_PLAFK (Q07785) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (PfPK5) Length = 288 Score = 131 bits (329), Expect = 2e-30 Identities = 69/165 (41%), Positives = 101/165 (61%), Gaps = 4/165 (2%) Frame = +3 Query: 123 RKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYVS 296 + F+LQ+L G+ Y H+ HRDLKP+NLL++ G +KIADFGLAR YT V Sbjct: 103 KSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVV 162 Query: 297 TRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDH 476 T WYRAP+VL+ + Y+ +ID+W++G I AE+ +PLFPG +E DQL +I +LGTP+ Sbjct: 163 TLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNS 222 Query: 477 SLWPEGMNLPR-SSSFQFFQIPPRNLWE-LIPNASLEALDLIKQL 605 WP LP+ +F ++ P WE + +DL+ ++ Sbjct: 223 KNWPNVTELPKYDPNFTVYEPLP---WESFLKGLDESGIDLLSKM 264
>CDC2H_PLAF7 (P61075) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 131 bits (329), Expect = 2e-30 Identities = 69/165 (41%), Positives = 101/165 (61%), Gaps = 4/165 (2%) Frame = +3 Query: 123 RKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYVS 296 + F+LQ+L G+ Y H+ HRDLKP+NLL++ G +KIADFGLAR YT V Sbjct: 103 KSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVV 162 Query: 297 TRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDH 476 T WYRAP+VL+ + Y+ +ID+W++G I AE+ +PLFPG +E DQL +I +LGTP+ Sbjct: 163 TLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNS 222 Query: 477 SLWPEGMNLPR-SSSFQFFQIPPRNLWE-LIPNASLEALDLIKQL 605 WP LP+ +F ++ P WE + +DL+ ++ Sbjct: 223 KNWPNVTELPKYDPNFTVYEPLP---WESFLKGLDESGIDLLSKM 264
>SUR1_CAEEL (P39745) Mitogen-activated protein kinase mpk-1 (EC 2.7.11.24) (MAP| kinase sur-1) Length = 444 Score = 131 bits (329), Expect = 2e-30 Identities = 76/188 (40%), Positives = 113/188 (60%), Gaps = 6/188 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADF 245 +LY +++ + S + + F+ QIL+GL Y+H+ HRDLKP NLL++ +KI DF Sbjct: 182 DLYKLLKTQK--LSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDF 239 Query: 246 GLAR----EVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 GLAR + T T+YV+TRWYRAPE++L + YT SID+W++G ILAE+ + PLF Sbjct: 240 GLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLF 299 Query: 414 PGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLW-ELIPNASLEALD 590 PG+ DQL I AV+G+P ++ +N S P+ W L P A ALD Sbjct: 300 PGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALD 359 Query: 591 LIKQLCSW 614 L+ ++ ++ Sbjct: 360 LLDKMLTF 367
>CDC2H_PLAKH (O96821) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 130 bits (328), Expect = 2e-30 Identities = 63/131 (48%), Positives = 87/131 (66%), Gaps = 2/131 (1%) Frame = +3 Query: 123 RKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYVS 296 + F+LQ+L G+ Y H + HRDLKP+NLL++ G +KIADFGLAR YT V Sbjct: 103 KSFLLQLLSGIAYCHEHRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVV 162 Query: 297 TRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDH 476 T WYRAP++L+ + Y+ ID+W++G I AE+ PLFPG +ETDQL +I +LGTP+ Sbjct: 163 TLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGVSETDQLMRIFRILGTPNS 222 Query: 477 SLWPEGMNLPR 509 + WP LP+ Sbjct: 223 ANWPSVTELPK 233
>CDC2H_PLACH (Q4Y4B1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 130 bits (328), Expect = 2e-30 Identities = 69/165 (41%), Positives = 101/165 (61%), Gaps = 4/165 (2%) Frame = +3 Query: 123 RKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYVS 296 + F+LQ+L G+ Y H + HRDLKP+NLL++ G +KIADFGLAR YT V Sbjct: 103 KSFLLQLLNGIAYCHEHRVLHRDLKPQNLLINREGELKIADFGLARAFGIPARRYTHEVV 162 Query: 297 TRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDH 476 T WYRAP++L+ + Y+ ID+W++G I AE+ PLFPG ++TDQL +I +LGTP+ Sbjct: 163 TLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGVSDTDQLMRIFKILGTPNS 222 Query: 477 SLWPEGMNLPR-SSSFQFFQIPPRNLWE-LIPNASLEALDLIKQL 605 WP+ LP+ +F ++ P WE I +DL+ ++ Sbjct: 223 QNWPDVFKLPKYDPNFPVYEPLP---WETFIKGLDDTGIDLLSKM 264
>PCTK3_RAT (O35832) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 130 bits (328), Expect = 2e-30 Identities = 68/164 (41%), Positives = 98/164 (59%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAR-EVCSTPPYTDYV 293 ++ FM Q+L+GL Y H HRDLKP+NLL++ G +K+ADFGLAR + T Y++ V Sbjct: 219 VKIFMFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEV 278 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR P+VLL ++ Y+ IDMW +G IL E+ T PLFPG T ++L I +LGTP Sbjct: 279 VTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPLFPGSTVKEELHLIFRLLGTPT 338 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 WP ++ ++ F + P+ L P E ++L+ L Sbjct: 339 EESWPGVTSISEFRAYNFPRYLPQPLLSHAPRLDTEGINLLTSL 382
>CDK4_XENLA (Q91727) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 319 Score = 130 bits (328), Expect = 2e-30 Identities = 70/135 (51%), Positives = 86/135 (63%), Gaps = 1/135 (0%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLAREVCSTPPYTDY 290 E I+ M Q L GL ++H N HRDLKPEN+LV S G VK+ADFGLAR T Sbjct: 115 ETIKDLMKQFLSGLEFLHLNCIVHRDLKPENILVTSGGQVKLADFGLARIYSCQMALTPV 174 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAPEVLLQ++ TP +D+W+ G I AE+F PLF G +E DQL KI ++G P Sbjct: 175 VVTLWYRAPEVLLQSTYATP-VDVWSAGCIFAEMFKRKPLFCGNSEADQLCKIFDIIGLP 233 Query: 471 DHSLWPEGMNLPRSS 515 WP + LPRS+ Sbjct: 234 SEEEWPVDVTLPRSA 248
>MKC1_CANAL (P43068) Mitogen-activated protein kinase MKC1 (EC 2.7.11.24) (MAP| kinase MKC1) Length = 501 Score = 130 bits (328), Expect = 2e-30 Identities = 76/197 (38%), Positives = 114/197 (57%), Gaps = 17/197 (8%) Frame = +3 Query: 66 CNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIAD 242 C+++ +IR P S++ + F+ Q+L GL ++H+ HRDLKP NLLV+ +KI D Sbjct: 134 CDMHQIIRS-GQPLSDQHYQSFIYQVLCGLNFIHSADVLHRDLKPGNLLVNADCELKICD 192 Query: 243 FGLAREVCSTPP-----YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSP 407 FGLAR P T+YV+TRWYRAPE++L + YT +ID+W++G ILAEL P Sbjct: 193 FGLARGFSENPDENAGFMTEYVATRWYRAPEIMLSFTNYTKAIDIWSVGCILAELLGGKP 252 Query: 408 LFPGETETDQLFKICAVLGTPDHSL-----------WPEGMNLPRSSSFQFFQIPPRNLW 554 LF G+ DQL +I +LGTP S + + + R +S++ Sbjct: 253 LFRGKDYVDQLNQILMILGTPPESTLQRIGSHRAQNYVRSLPITRKASYE---------- 302 Query: 555 ELIPNASLEALDLIKQL 605 EL P+A+ ALDL++++ Sbjct: 303 ELFPDANPLALDLLERM 319
>PCTK2_RAT (O35831) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 130 bits (327), Expect = 3e-30 Identities = 69/171 (40%), Positives = 98/171 (57%), Gaps = 2/171 (1%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAR-EVCSTPPY 281 S ++ F+ QIL+GL Y H HRDLKP+NLL++ G +K+ADFGLAR + T Y Sbjct: 286 SMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTY 345 Query: 282 TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVL 461 ++ V T WYR P+VLL +S Y+ IDMW +G I E+ + PLFPG T D+L I +L Sbjct: 346 SNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLL 405 Query: 462 GTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 GTP WP + ++ F + P+ L P E ++LI + + Sbjct: 406 GTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQY 456
>PCTK2_MOUSE (Q8K0D0) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 130 bits (327), Expect = 3e-30 Identities = 69/171 (40%), Positives = 98/171 (57%), Gaps = 2/171 (1%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAR-EVCSTPPY 281 S ++ F+ QIL+GL Y H HRDLKP+NLL++ G +K+ADFGLAR + T Y Sbjct: 286 SMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTY 345 Query: 282 TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVL 461 ++ V T WYR P+VLL +S Y+ IDMW +G I E+ + PLFPG T D+L I +L Sbjct: 346 SNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLL 405 Query: 462 GTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 GTP WP + ++ F + P+ L P E ++LI + + Sbjct: 406 GTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQY 456
>MK01_HUMAN (P28482) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 130 bits (326), Expect = 4e-30 Identities = 77/190 (40%), Positives = 115/190 (60%), Gaps = 8/190 (4%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADF 245 +LY +++ + S + I F+ QIL+GL Y+H+ HRDLKP NLL++ +KI DF Sbjct: 110 DLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDF 167 Query: 246 GLAR----EVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 GLAR + T T+YV+TRWYRAPE++L + YT SID+W++G ILAE+ + P+F Sbjct: 168 GLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 227 Query: 414 PGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNL--W-ELIPNASLEA 584 PG+ DQL I +LG+P +NL + +P +N W L PNA +A Sbjct: 228 PGKHYLDQLNHILGILGSPSQEDLNCIINLKARN--YLLSLPHKNKVPWNRLFPNADSKA 285 Query: 585 LDLIKQLCSW 614 LDL+ ++ ++ Sbjct: 286 LDLLDKMLTF 295
>MK01_BOVIN (P46196) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 130 bits (326), Expect = 4e-30 Identities = 77/190 (40%), Positives = 115/190 (60%), Gaps = 8/190 (4%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADF 245 +LY +++ + S + I F+ QIL+GL Y+H+ HRDLKP NLL++ +KI DF Sbjct: 110 DLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDF 167 Query: 246 GLAR----EVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 GLAR + T T+YV+TRWYRAPE++L + YT SID+W++G ILAE+ + P+F Sbjct: 168 GLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 227 Query: 414 PGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNL--W-ELIPNASLEA 584 PG+ DQL I +LG+P +NL + +P +N W L PNA +A Sbjct: 228 PGKHYLDQLNHILGILGSPSQEDLNCIINLKARN--YLLSLPHKNKVPWNRLFPNADSKA 285 Query: 585 LDLIKQLCSW 614 LDL+ ++ ++ Sbjct: 286 LDLLDKMLTF 295
>MK01_RAT (P63086) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 130 bits (326), Expect = 4e-30 Identities = 77/190 (40%), Positives = 115/190 (60%), Gaps = 8/190 (4%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADF 245 +LY +++ + S + I F+ QIL+GL Y+H+ HRDLKP NLL++ +KI DF Sbjct: 108 DLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDF 165 Query: 246 GLAR----EVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 GLAR + T T+YV+TRWYRAPE++L + YT SID+W++G ILAE+ + P+F Sbjct: 166 GLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 225 Query: 414 PGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNL--W-ELIPNASLEA 584 PG+ DQL I +LG+P +NL + +P +N W L PNA +A Sbjct: 226 PGKHYLDQLNHILGILGSPSQEDLNCIINLKARN--YLLSLPHKNKVPWNRLFPNADSKA 283 Query: 585 LDLIKQLCSW 614 LDL+ ++ ++ Sbjct: 284 LDLLDKMLTF 293
>MK01_MOUSE (P63085) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 130 bits (326), Expect = 4e-30 Identities = 77/190 (40%), Positives = 115/190 (60%), Gaps = 8/190 (4%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADF 245 +LY +++ + S + I F+ QIL+GL Y+H+ HRDLKP NLL++ +KI DF Sbjct: 108 DLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDF 165 Query: 246 GLAR----EVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 GLAR + T T+YV+TRWYRAPE++L + YT SID+W++G ILAE+ + P+F Sbjct: 166 GLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 225 Query: 414 PGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNL--W-ELIPNASLEA 584 PG+ DQL I +LG+P +NL + +P +N W L PNA +A Sbjct: 226 PGKHYLDQLNHILGILGSPSQEDLNCIINLKARN--YLLSLPHKNKVPWNRLFPNADSKA 283 Query: 585 LDLIKQLCSW 614 LDL+ ++ ++ Sbjct: 284 LDLLDKMLTF 293
>NTF6_TOBAC (Q40531) Mitogen-activated protein kinase homolog NTF6 (EC| 2.7.11.24) (P43) Length = 371 Score = 130 bits (326), Expect = 4e-30 Identities = 74/185 (40%), Positives = 110/185 (59%), Gaps = 6/185 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L+ +IR A +++ + F+ Q+L+GL Y+H+ HRDLKP NLL++ N +KI DF Sbjct: 125 DLHQIIRSSQA-LTDDHCQYFLYQLLRGLKYVHSANVLHRDLKPSNLLLNANCDLKICDF 183 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLAR T+YV TRWYRAPE+LL + YT +ID+W++G IL EL PLFPG Sbjct: 184 GLARTTSEADFMTEYVVTRWYRAPELLLNCTEYTAAIDIWSVGCILMELIKREPLFPGRD 243 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFF-----QIPPRNLWELIPNASLEALD 590 QL I A+LG+P+ S + RS + + + ++P + P+ S ALD Sbjct: 244 YAQQLGLIIALLGSPEDS----DLGFLRSDNARKYVKHLPRVPRHPFSQKFPDVSPLALD 299 Query: 591 LIKQL 605 L +++ Sbjct: 300 LAERM 304
>PCTK2_HUMAN (Q00537) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 130 bits (326), Expect = 4e-30 Identities = 69/171 (40%), Positives = 98/171 (57%), Gaps = 2/171 (1%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAR-EVCSTPPY 281 S ++ F+ QIL+GL Y H HRDLKP+NLL++ G +K+ADFGLAR + T Y Sbjct: 286 SMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTY 345 Query: 282 TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVL 461 ++ V T WYR P+VLL +S Y+ IDMW +G I E+ + PLFPG T D+L I +L Sbjct: 346 SNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLL 405 Query: 462 GTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 GTP WP + ++ F + P+ L P E ++LI + + Sbjct: 406 GTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQY 456
>SPK1_SCHPO (P27638) Mitogen-activated protein kinase spk1 (EC 2.7.11.24) (MAP| kinase spk1) (MAPK) Length = 372 Score = 129 bits (325), Expect = 5e-30 Identities = 80/190 (42%), Positives = 113/190 (59%), Gaps = 8/190 (4%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +LY VIR S P S++ + F QIL+ L MH+ G HRDLKP NLL++ N +K+ADF Sbjct: 125 DLYRVIR--SQPLSDDHCQYFTYQILRALKAMHSAGVVHRDLKPSNLLLNANCDLKVADF 182 Query: 246 GLAREVCS---TPPY-TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 GLAR + P + T+YV+TRWYRAPE++L Y+ +ID+W+ G ILAE+ + PLF Sbjct: 183 GLARSTTAQGGNPGFMTEYVATRWYRAPEIMLSFREYSKAIDLWSTGCILAEMLSARPLF 242 Query: 414 PGETETDQLFKICAVLGTP---DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEA 584 PG+ Q+ I +LGTP D S S F P + L P AS +A Sbjct: 243 PGKDYHSQITLILNILGTPTMDDFSRIKSARARKYIKSLPF--TPKVSFKALFPQASPDA 300 Query: 585 LDLIKQLCSW 614 +DL+++L ++ Sbjct: 301 IDLLEKLLTF 310
>MK01_XENLA (P26696) Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Myelin| xP42 protein kinase) (Myelin basic protein kinase) (MBP kinase) (M phase MAP kinase) Length = 361 Score = 129 bits (325), Expect = 5e-30 Identities = 77/190 (40%), Positives = 115/190 (60%), Gaps = 8/190 (4%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADF 245 +LY +++ + S + I F+ QIL+GL Y+H+ HRDLKP NLL++ +KI DF Sbjct: 114 DLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDF 171 Query: 246 GLAR----EVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 GLAR + T T+YV+TRWYRAPE++L + YT SID+W++G ILAE+ + P+F Sbjct: 172 GLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 231 Query: 414 PGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNL--W-ELIPNASLEA 584 PG+ DQL I +LG+P +NL + +P +N W L PNA +A Sbjct: 232 PGKHYLDQLNHILGILGSPSQEDLNCIINLKARN--YLLSLPHKNKVPWNRLFPNADPKA 289 Query: 585 LDLIKQLCSW 614 LDL+ ++ ++ Sbjct: 290 LDLLDKMLTF 299
>YP62_CAEEL (Q09437) Putative serine/threonine-protein kinase B0495.2 (EC| 2.7.11.1) Length = 719 Score = 129 bits (325), Expect = 5e-30 Identities = 73/177 (41%), Positives = 99/177 (55%), Gaps = 2/177 (1%) Frame = +3 Query: 27 KITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPEN 206 KI F+ +L D + R+ FS E + + Q+L G+ +MH HRDLK N Sbjct: 430 KIYMAMEFVEHDMKSLLDTMSRRNKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSN 489 Query: 207 LLVSN-GIVKIADFGLAREVCST-PPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAI 380 LL+S+ GI+KIADFGLARE +T V T WYR+PE+LL Y+ +DMW++G I Sbjct: 490 LLMSHKGILKIADFGLAREYGDPLKKFTSIVVTLWYRSPELLLGTRLYSTPVDMWSVGCI 549 Query: 381 LAELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNL 551 +AE L PLFPG E +Q+ KI +GTP S+WP L + F + P L Sbjct: 550 MAEFILLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKALTFEKYPYNQL 606
>MPK3_ARATH (Q39023) Mitogen-activated protein kinase homolog 3 (EC 2.7.11.24)| (MAP kinase 3) (AtMPK3) Length = 370 Score = 129 bits (324), Expect = 7e-30 Identities = 75/186 (40%), Positives = 110/186 (59%), Gaps = 4/186 (2%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L+ +IR + SEE + F+ Q+L+GL Y+H+ HRDLKP NLL++ N +KI DF Sbjct: 125 DLHQIIRSNQS-LSEEHCQYFLYQLLRGLKYIHSANIIHRDLKPSNLLLNANCDLKICDF 183 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLAR T+YV TRWYRAPE+LL +S YT +ID+W++G I EL PLFPG+ Sbjct: 184 GLARPTSENDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMNRKPLFPGKD 243 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIP--PRN-LWELIPNASLEALDLI 596 Q+ + +LGTP S G + Q+P PR L +L + + A+DL+ Sbjct: 244 HVHQMRLLTELLGTPTES--DLGFTHNEDAKRYIRQLPNFPRQPLAKLFSHVNPMAIDLV 301 Query: 597 KQLCSW 614 ++ ++ Sbjct: 302 DRMLTF 307
>CDC2_CAEEL (P34556) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 332 Score = 129 bits (324), Expect = 7e-30 Identities = 65/133 (48%), Positives = 86/133 (64%), Gaps = 2/133 (1%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLAREV-CSTPPYTD 287 E ++ + QILQ + + H HRDLKP+NLLV +NG +K+ADFGLAR + YT Sbjct: 121 ETLKSYTFQILQAMCFCHQRRVIHRDLKPQNLLVDNNGAIKLADFGLARAIGIPIRVYTH 180 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGT 467 V T WYRAPE+L+ A Y+ +DMW+IG I AE+ T PLF G++E D+LF+I VLGT Sbjct: 181 EVVTLWYRAPEILMGAQRYSMGVDMWSIGCIFAEMATKKPLFQGDSEIDELFRIFRVLGT 240 Query: 468 PDHSLWPEGMNLP 506 P W +LP Sbjct: 241 PTELEWNGVESLP 253
>GSK3_SCHPO (Q10452) Protein kinase gsk3 (EC 2.7.11.1) (Protein kinaae skp1)| Length = 387 Score = 128 bits (322), Expect = 1e-29 Identities = 68/169 (40%), Positives = 108/169 (63%), Gaps = 3/169 (1%) Frame = +3 Query: 117 EIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS--NGIVKIADFGLAREVCSTPPYTDY 290 E++ ++ Q+L+ L Y+H +G HRD+KP+NLL+ NGI+K+ DFG A+ + + P Y Sbjct: 133 EVKLYIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKILVAGEPNVSY 192 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ A+ YT +ID+W+ G ++AEL PLFPGE+ DQL +I +LGTP Sbjct: 193 ICSRYYRAPELIFGATDYTHAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGTP 252 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIP-NASLEALDLIKQLCSW 614 + MN P +F QI P+ L + + L+ALDL+ ++ + Sbjct: 253 SRE-QIKTMN-PNYMEHRFPQIRPQPLSRVFSRSVPLDALDLLSKMLQY 299
>PEF1_SCHPO (O74456) Serine/threonine-protein kinase pef1 (EC 2.7.11.22)| (Cyclin-dependent kinase pef1) (PHO85 homolog) Length = 288 Score = 127 bits (320), Expect = 2e-29 Identities = 69/165 (41%), Positives = 101/165 (61%), Gaps = 2/165 (1%) Frame = +3 Query: 117 EIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLAREV-CSTPPYTDY 290 +++ F Q+L+G+ + H N HRDLKP+NLL+ S G +K+ADFGLAR + +++ Sbjct: 102 QVKNFTQQLLKGISFCHENRVLHRDLKPQNLLINSRGELKLADFGLARSIGIPVNTFSNE 161 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 V T WYRAP+VLL + Y+ SID+W++G I+AE+ T PLF G DQL KI +LGTP Sbjct: 162 VVTLWYRAPDVLLGSRVYSTSIDIWSVGCIMAEMATGRPLFAGSNNEDQLLKIFRLLGTP 221 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 WP G++L F ++L L P LDL++++ Sbjct: 222 TEQSWP-GISLLPEYKPTFPIYKAQDLAYLFPTFDPLGLDLLRRM 265
>KIN28_YEAST (P06242) Serine/threonine-protein kinase KIN28 (EC 2.7.11.23)| Length = 306 Score = 127 bits (320), Expect = 2e-29 Identities = 73/175 (41%), Positives = 102/175 (58%), Gaps = 3/175 (1%) Frame = +3 Query: 81 VIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAR 257 VI+++S F+ +I+ +ML L+G+ + H N HRDLKP NLL S +G +K+ADFGLAR Sbjct: 93 VIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLAR 152 Query: 258 EVCSTPPY-TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETD 434 + + T V TRWYRAPE+L A YT +ID+W++G I AEL P PG+ + D Sbjct: 153 AIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVD 212 Query: 435 QLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRN-LWELIPNASLEALDLI 596 Q+ LGTP WPE + + Q + P R+ L + AS ALD + Sbjct: 213 QMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYALDFM 267
>CRK1_SCHPO (Q12126) Serine/threonine-protein kinase crk1 (EC 2.7.11.23)| (Mitotic catastrophe suppressor 6) Length = 335 Score = 127 bits (318), Expect = 3e-29 Identities = 64/179 (35%), Positives = 102/179 (56%), Gaps = 1/179 (0%) Frame = +3 Query: 81 VIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAR 257 +I+++ F I+ +M+ +L+GL ++H+ HRDLKP NLL+S+ G++K+ADFGL+R Sbjct: 97 LIKDKFIVFQPAHIKSWMVMLLRGLHHIHSRFILHRDLKPNNLLISSDGVLKLADFGLSR 156 Query: 258 EVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQ 437 + + + V TRWYR PE+ + +Y +DMW++G I AEL +P PGE++ DQ Sbjct: 157 DFGTPSHMSHQVITRWYRPPELFMGCRSYGTGVDMWSVGCIFAELMLRTPYLPGESDLDQ 216 Query: 438 LFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 L I LGTP+ + LP + P + L A E +DL+K + + Sbjct: 217 LNVIFRALGTPEPEVIKSMQQLPNYVEMKHIPPPNGGMEALFSAAGHEEIDLLKMMLDY 275
>CC2H3_TRYBB (P54666) Cell division control protein 2 homolog 3 (EC 2.7.11.22)| Length = 311 Score = 127 bits (318), Expect = 3e-29 Identities = 80/201 (39%), Positives = 116/201 (57%), Gaps = 6/201 (2%) Frame = +3 Query: 21 DGKITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKP 200 DGK+ +++ +L + +R F+ ++K + Q+L+GL + H + HRDLKP Sbjct: 92 DGKLYLIFEYVDH---DLKKALEKRGGAFTGTTLKKIIYQLLEGLSFCHRHRIVHRDLKP 148 Query: 201 ENLLVS-NGIVKIADFGLAREV-CSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIG 374 N+LV+ + VKIADFGLAR YT V T WYRAPE+LL YTP++DMW+IG Sbjct: 149 ANILVTTDNSVKIADFGLARAFQIPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDMWSIG 208 Query: 375 AILAELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPP---- 542 I AEL LF G++E QLF+I VLGTP + EG L SS + + P Sbjct: 209 CIFAELARGKVLFRGDSEIGQLFEIFQVLGTP---MDAEGSWLGVSSLPDYRDVFPKWSG 265 Query: 543 RNLWELIPNASLEALDLIKQL 605 + L +++P +A+DL+ Q+ Sbjct: 266 KPLTQVLPTLDGDAVDLLSQM 286
>PCTK3_PONPY (Q5RD01) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 125 bits (315), Expect = 8e-29 Identities = 67/168 (39%), Positives = 96/168 (57%), Gaps = 2/168 (1%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAR-EVCSTPPY 281 S ++ FM Q+L+GL Y H+ HRDLKP+NLL++ G +K+ADFGLAR + T Y Sbjct: 236 SMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTY 295 Query: 282 TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVL 461 ++ V T WYR P+VLL ++ Y+ IDMW +G I E+ T PLFPG T ++L I +L Sbjct: 296 SNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLL 355 Query: 462 GTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 GTP WP ++ F + P+ L P + + L+ L Sbjct: 356 GTPTEETWPGVTAFSEFRTYSFPRYLPQPLISHAPRLDTDGIQLLSSL 403
>CDKL5_HUMAN (O76039) Cyclin-dependent kinase-like 5 (EC 2.7.11.22)| (Serine/threonine-protein kinase 9) Length = 1030 Score = 125 bits (315), Expect = 8e-29 Identities = 62/135 (45%), Positives = 91/135 (67%), Gaps = 3/135 (2%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 N+ +++ E E+++ ++ Q+++ + + H N HRD+KPENLL+S N ++K+ DF Sbjct: 95 NMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDF 154 Query: 246 GLAREVC--STPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPG 419 G AR + + YT+YV+TRWYR+PE+LL A Y S+DMW++G IL EL PLFPG Sbjct: 155 GFARNLSEGNNANYTEYVATRWYRSPELLLGAP-YGKSVDMWSVGCILGELSDGQPLFPG 213 Query: 420 ETETDQLFKICAVLG 464 E+E DQLF I VLG Sbjct: 214 ESEIDQLFTIQKVLG 228
>CDK9_SCHPO (Q96WV9) Serine/threonine-protein kinase cdk9 (EC 2.7.11.1)| (Cyclin-dependent kinase cdk9) Length = 591 Score = 125 bits (314), Expect = 1e-28 Identities = 70/176 (39%), Positives = 98/176 (55%), Gaps = 15/176 (8%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ S F+E +I+ +M Q+ G Y+H+ HRDLK NLL+ N GI+KIADF Sbjct: 126 DLSGLLENPSVKFTEPQIKCYMKQLFAGTKYLHDQLILHRDLKAANLLIDNHGILKIADF 185 Query: 246 GLAREVCST----------PP----YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAIL 383 GLAR + PP YT V TRWYR+PE+LL YT +IDMW++G I+ Sbjct: 186 GLARVITEESYANKNPGLPPPNRREYTGCVVTRWYRSPELLLGERRYTTAIDMWSVGCIM 245 Query: 384 AELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNL 551 AE++ P+ G ++ DQL KI + G+P + P LP + F PR L Sbjct: 246 AEMYKGRPILQGSSDLDQLDKIFRLCGSPTQATMPNWEKLPGCEGVRSFPSHPRTL 301
>BUR1_KLULA (Q6CRA9) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 645 Score = 125 bits (314), Expect = 1e-28 Identities = 63/162 (38%), Positives = 92/162 (56%), Gaps = 14/162 (8%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ F +++ MLQ+L+G+ Y+H N + HRD+K N+L+ + G+VKIADF Sbjct: 168 DLTGLLHNPRVEFGMADVKNIMLQLLEGINYIHCNKFLHRDIKTANILIDHKGVVKIADF 227 Query: 246 GLAREVCSTPP-------------YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILA 386 GLAR +PP YT V TRWYRAPE++L YT ++D+W IG + A Sbjct: 228 GLARNYYGSPPNLKYPGGAGSGAKYTSVVVTRWYRAPEIVLGDRHYTTAVDIWGIGCVFA 287 Query: 387 ELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRS 512 E F P+ G+T+ DQ I ++GTP W +LP S Sbjct: 288 EFFEKKPILQGQTDIDQGHVIFKLMGTPSMDEWGLAYHLPGS 329
>CPK1_CRYNE (Q8NK05) Mitogen-activated protein kinase CPK1 (EC 2.7.11.24)| (Stress-activated protein kinase CPK1) Length = 366 Score = 125 bits (314), Expect = 1e-28 Identities = 75/181 (41%), Positives = 100/181 (55%), Gaps = 11/181 (6%) Frame = +3 Query: 93 RSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCS 269 RS S++ + F+ Q L+GL +H+ HRDLKP NLL++ N +KI DFGLAR Sbjct: 108 RSQELSDDHCQYFVYQTLRGLKALHSADVLHRDLKPSNLLLNANCDLKICDFGLARSSAK 167 Query: 270 TPP---------YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGE 422 PP T+YV+TRWYRAPEV+L YT +ID+W++G ILAE+ PLFPG Sbjct: 168 PPPGTSDGGQGFMTEYVATRWYRAPEVMLSFQEYTKAIDLWSVGCILAEMINGKPLFPGR 227 Query: 423 TETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELI-PNASLEALDLIK 599 QL I VLGTP + E + + + R + I P A A+DL+K Sbjct: 228 DYHHQLSLILQVLGTPTMDDFNEITSQRSKDYLRALEFTRRQDFSAICPKAKPAAVDLLK 287 Query: 600 Q 602 Q Sbjct: 288 Q 288
>CDC2_DROME (P23572) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 297 Score = 125 bits (313), Expect = 1e-28 Identities = 65/166 (39%), Positives = 97/166 (58%), Gaps = 2/166 (1%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTD 287 E +R ++ QI +++ H HRDLKP+NLL+ +G++K+ADFGL R YT Sbjct: 103 ELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTH 162 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGT 467 + T WYRAPEVLL + Y+ +D+W+IG I AE+ T PLF G++E DQLF++ +L T Sbjct: 163 EIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKT 222 Query: 468 PDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 P +WP +LP + F L + N +DLI+++ Sbjct: 223 PTEDIWPGVTSLPDYKN-TFPCWSTNQLTNQLKNLDANGIDLIQKM 267
>CDK5_XENLA (P51166) Cell division protein kinase 5 (EC 2.7.11.22) (Neuronal| cyclin-dependent kinase 5) Length = 292 Score = 124 bits (312), Expect = 2e-28 Identities = 70/167 (41%), Positives = 95/167 (56%), Gaps = 3/167 (1%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTD 287 E ++ FM Q+L+GL + H+ HRDLKP+NLL++ NG +K+ADFGLAR Y+ Sbjct: 101 EIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA 160 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLS-PLFPGETETDQLFKICAVLG 464 V T WYR P+VL A Y+ SIDMW+ G I AEL PLFPG DQL +I +LG Sbjct: 161 EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG 220 Query: 465 TPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TP WP LP + + +L ++P + DL++ L Sbjct: 221 TPTEEQWPAMTKLPDYKPYPMYP-ATMSLVNVVPKLNATGRDLLQNL 266
>MK13_PANTR (Q9N272) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) Length = 365 Score = 124 bits (312), Expect = 2e-28 Identities = 71/169 (42%), Positives = 101/169 (59%), Gaps = 2/169 (1%) Frame = +3 Query: 105 FSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPY 281 FSEE+I+ + Q+L+GL Y+H+ G HRDLKP NL V+ +KI DFGLAR + Sbjct: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH--ADAEM 179 Query: 282 TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVL 461 T YV TRWYRAPEV+L Y ++D+W++G I+AE+ T LF G+ DQL +I V Sbjct: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 Query: 462 GTPDHSLWPEGMNLPRSSSFQFF-QIPPRNLWELIPNASLEALDLIKQL 605 G P + + S Q Q P ++ +L P AS +A DL++++ Sbjct: 240 GVPGTEFVQKLNDXAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288
>CDKL4_MOUSE (Q3TZA2) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 342 Score = 124 bits (312), Expect = 2e-28 Identities = 62/139 (44%), Positives = 90/139 (64%), Gaps = 1/139 (0%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREVCSTPPYT 284 S+ I+ + Q LQ L + H + HRD+KPEN+L++ G++KI DFG AR + YT Sbjct: 99 SDGVIKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPGDAYT 158 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 DYV+TRWYRAPE+L+ + Y S+D+WA+G + AEL T PL+PG+++ DQL+ I LG Sbjct: 159 DYVATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG 218 Query: 465 TPDHSLWPEGMNLPRSSSF 521 L P ++ RS+ F Sbjct: 219 ----KLIPRHQSIFRSNQF 233
>PMK2_CAEEL (Q8MXI4) Mitogen-activated protein kinase pmk-2 (EC 2.7.11.24) (p38| MAP kinase 2) (Stress-activated protein kinase pmk-2) Length = 419 Score = 124 bits (312), Expect = 2e-28 Identities = 73/189 (38%), Positives = 104/189 (55%), Gaps = 23/189 (12%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN------------------GIVK 233 ++E+I+ + Q+L+GL Y+H+ G HRDLKP N+ V+ K Sbjct: 148 TDEQIQLLIYQVLRGLKYIHSAGIIHRDLKPSNIAVNERCEVKVFLSFSQLSFLILSFFK 207 Query: 234 IADFGLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 I DFGLAR T YV+TRWYRAPE++L YT ++D+W++G ILAEL + PLF Sbjct: 208 ILDFGLAR--AQDAEMTGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELVSGRPLF 265 Query: 414 PGETETDQLFKICAVLGTPDHSLW-----PEGMNLPRSSSFQFFQIPPRNLWELIPNASL 578 PG+ DQL KI +V+GTP W E N ++ S I ++ L P AS Sbjct: 266 PGDDHIDQLTKIMSVVGTPKEEFWSKIQSEEARNYIKNRS----PIIRQDFVTLFPMASP 321 Query: 579 EALDLIKQL 605 AL+L++ + Sbjct: 322 YALELLEMM 330
>CDC2H_DICDI (P34117) CDC2-like serine/threonine-protein kinase CRP (EC| 2.7.11.22) (EC 2.7.11.23) Length = 292 Score = 124 bits (311), Expect = 2e-28 Identities = 68/184 (36%), Positives = 105/184 (57%), Gaps = 2/184 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L + E S+ I+ FM Q+L+G+ + H++ HRDLKP+NLL++ G +K+ADF Sbjct: 86 DLKKYLDECGGEISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADF 145 Query: 246 GLAREV-CSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGE 422 GLAR Y+ V T WYRAP+VL+ + Y+ ID+W+ I AE+ + PLFPG Sbjct: 146 GLARAFGIPVRTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSALCIFAEMASGRPLFPGS 205 Query: 423 TETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQ 602 +DQLF+I +LGTP+ WP LP + F P L ++ + L+L+ + Sbjct: 206 GTSDQLFRIFKILGTPNEESWPSITELPEYKT-DFPVHPAHQLSSIVHGLDEKGLNLLSK 264 Query: 603 LCSW 614 + + Sbjct: 265 MLQY 268
>MK13_HUMAN (O15264) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 365 Score = 124 bits (311), Expect = 2e-28 Identities = 71/169 (42%), Positives = 101/169 (59%), Gaps = 2/169 (1%) Frame = +3 Query: 105 FSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPY 281 FSEE+I+ + Q+L+GL Y+H+ G HRDLKP NL V+ +KI DFGLAR + Sbjct: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH--ADAEM 179 Query: 282 TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVL 461 T YV TRWYRAPEV+L Y ++D+W++G I+AE+ T LF G+ DQL +I V Sbjct: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 Query: 462 GTPDHSLWPEGMNLPRSSSFQFF-QIPPRNLWELIPNASLEALDLIKQL 605 G P + + S Q Q P ++ +L P AS +A DL++++ Sbjct: 240 GVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKM 288
>CDKL2_MACFA (Q4R7T5) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 570 Score = 124 bits (311), Expect = 2e-28 Identities = 56/117 (47%), Positives = 85/117 (72%), Gaps = 2/117 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP-YTDYV 293 ++K++ QI+ G+ + H++ HRD+KPEN+LVS +G+VK+ DFG AR + + YTDYV Sbjct: 103 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYV 162 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 +TRWYRAPE+L+ Y ++D+WAIG ++ E+F PLFPG+++ DQL+ I LG Sbjct: 163 ATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLG 219
>MK13_RAT (Q9WTY9) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 366 Score = 124 bits (311), Expect = 2e-28 Identities = 70/169 (41%), Positives = 101/169 (59%), Gaps = 2/169 (1%) Frame = +3 Query: 105 FSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPY 281 FSEE+++ + Q+L+GL Y+H+ G HRDLKP NL V+ +KI DFGLAR + Sbjct: 122 FSEEKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARH--TDAEM 179 Query: 282 TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVL 461 T YV TRWYRAPEV+L Y ++D+W++G I+AE+ T LF G+ DQL +I V Sbjct: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 Query: 462 GTPDHSLWPEGMNLPRSSSFQFF-QIPPRNLWELIPNASLEALDLIKQL 605 G P + + S Q Q P ++ +L P AS +A+DL+ ++ Sbjct: 240 GVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAVDLLDKM 288
>PCTK3_HUMAN (Q07002) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 124 bits (311), Expect = 2e-28 Identities = 69/171 (40%), Positives = 98/171 (57%), Gaps = 5/171 (2%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAR-EVCSTPPY 281 S ++ FM Q+L+GL Y H+ HRDLKP+NLL++ G +K+ADFGLAR + T Y Sbjct: 236 SMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTY 295 Query: 282 TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVL 461 ++ V T WYR P+VLL ++ Y+ IDMW +G I E+ T PLFPG T ++L I +L Sbjct: 296 SNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLL 355 Query: 462 GTPDHSLWPEGMNLPRSSSFQFFQIP---PRNLWELIPNASLEALDLIKQL 605 GTP WP + S F+ + P P+ L P + + L+ L Sbjct: 356 GTPTEETWP---GVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSL 403
>CDKL2_PONPY (Q5R754) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 493 Score = 124 bits (311), Expect = 2e-28 Identities = 56/117 (47%), Positives = 85/117 (72%), Gaps = 2/117 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP-YTDYV 293 ++K++ QI+ G+ + H++ HRD+KPEN+LVS +G+VK+ DFG AR + + YTDYV Sbjct: 103 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSKSGVVKLCDFGFARTLAAPGEVYTDYV 162 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 +TRWYRAPE+L+ Y ++D+WAIG ++ E+F PLFPG+++ DQL+ I LG Sbjct: 163 ATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLG 219
>CDKL2_HUMAN (Q92772) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE) Length = 493 Score = 124 bits (311), Expect = 2e-28 Identities = 56/117 (47%), Positives = 85/117 (72%), Gaps = 2/117 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP-YTDYV 293 ++K++ QI+ G+ + H++ HRD+KPEN+LVS +G+VK+ DFG AR + + YTDYV Sbjct: 103 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYV 162 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 +TRWYRAPE+L+ Y ++D+WAIG ++ E+F PLFPG+++ DQL+ I LG Sbjct: 163 ATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLG 219
>PCTK1_HUMAN (Q00536) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 124 bits (311), Expect = 2e-28 Identities = 64/164 (39%), Positives = 95/164 (57%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAR-EVCSTPPYTDYV 293 ++ F+ Q+L+GL Y H HRDLKP+NLL++ G +K+ADFGLAR + T Y++ V Sbjct: 263 VKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEV 322 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR P++LL ++ Y+ IDMW +G I E+ T PLFPG T +QL I +LGTP Sbjct: 323 VTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPT 382 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 WP ++ ++ + + L P + DL+ +L Sbjct: 383 EETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKL 426
>KSG2_ARATH (O23145) Shaggy-related protein kinase beta (EC 2.7.11.1)| (ASK-beta) Length = 431 Score = 124 bits (310), Expect = 3e-28 Identities = 74/170 (43%), Positives = 104/170 (61%), Gaps = 5/170 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNN-GYFHRDLKPENLLVSNGI--VKIADFGLAREVCSTPPYTDY 290 I+ + QI + + Y+H G HRD+KP+NLLV+N VKI DFG A+ + P Y Sbjct: 203 IQLYTYQICRAMNYLHQVVGVCHRDIKPQNLLVNNVTHEVKICDFGSAKMLIPGEPNISY 262 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ A+ YT +IDMW++G ++AELF PLFPGET DQL +I +LGTP Sbjct: 263 ICSRYYRAPELIFGATEYTSAIDMWSVGCVMAELFLGHPLFPGETSVDQLVEIIKILGTP 322 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELI--PNASLEALDLIKQLCSW 614 + MN PR + F+F QI + W I S EA+DL +L + Sbjct: 323 ARE-EIKNMN-PRYNDFKFPQIKAQP-WHKIFRRQVSPEAMDLASRLLQY 369
>PCTK1_MOUSE (Q04735) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) (CRK5) Length = 496 Score = 124 bits (310), Expect = 3e-28 Identities = 64/164 (39%), Positives = 95/164 (57%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAR-EVCSTPPYTDYV 293 ++ F+ Q+L+GL Y H HRDLKP+NLL++ G +K+ADFGLAR + T Y++ V Sbjct: 263 VKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEV 322 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR P++LL ++ Y+ IDMW +G I E+ T PLFPG T +QL I +LGTP Sbjct: 323 VTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPT 382 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 WP ++ ++ + + L P + DL+ +L Sbjct: 383 EETWPGILSNEEFRTYNYPKYRAEALLSHAPRLDSDGADLLTKL 426
>CDC2C_DROME (P23573) Cell division control protein 2 cognate (EC 2.7.11.22) (EC| 2.7.11.23) Length = 314 Score = 124 bits (310), Expect = 3e-28 Identities = 64/149 (42%), Positives = 92/149 (61%), Gaps = 3/149 (2%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ ++ F+ + I+ +M QIL + + H N HRDLKP+NLLV G +K+ADF Sbjct: 90 DLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLLVDTAGKIKLADF 149 Query: 246 GLAREVCSTP--PYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPG 419 GLAR + P YT V T WYRAPE+LL Y+ +D+W++G I +E+ LFPG Sbjct: 150 GLARAF-NVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEMIMRRSLFPG 208 Query: 420 ETETDQLFKICAVLGTPDHSLWPEGMNLP 506 ++E DQL++I L TPD + WP LP Sbjct: 209 DSEIDQLYRIFRTLSTPDETNWPGVTQLP 237
>AL2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22)| (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) Length = 384 Score = 123 bits (309), Expect = 4e-28 Identities = 73/169 (43%), Positives = 101/169 (59%), Gaps = 7/169 (4%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAR-EVCSTPPYTDYV 293 +R FM Q+L+GL Y+H+ HRDLKP+NLL+S+ G +K+ADFGLAR + + Y+ V Sbjct: 150 VRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEV 209 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETE-TDQLFKICAVLGTP 470 T WYR P+ LL A+ Y+ +D+W G I E+F PLFPG + +QL KI VLG P Sbjct: 210 VTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVP 269 Query: 471 DHSLWPEGMNLPRSSSFQFFQIP-PRNL---WELIPNASLEALDLIKQL 605 WP LP + ++F +P PR+L W + EA DL Q+ Sbjct: 270 TEDTWPGVSKLPNYNP-EWFPLPTPRSLHVVWNRLGRVP-EAEDLASQM 316
>ERK1_CANAL (P28869) Extracellular signal-regulated kinase 1 (EC 2.7.11.24)| (ERK1) (MAP kinase 1) (MAPK 1) Length = 417 Score = 123 bits (309), Expect = 4e-28 Identities = 67/140 (47%), Positives = 93/140 (66%), Gaps = 5/140 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADF 245 +L+ VIR ++ S++ I+ F+ Q L+ L MH+ HRDLKP NLL+ SN +KI DF Sbjct: 154 DLHRVIRTQN--LSDDHIQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNSNCDLKICDF 211 Query: 246 GLAREVCSTPP----YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLF 413 GLAR + S T+YV+TRWYRAPE++L YT +ID+W++G ILAE+ + PLF Sbjct: 212 GLARSIASQEDNYGFMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCILAEMLSGRPLF 271 Query: 414 PGETETDQLFKICAVLGTPD 473 PG +QL+ I VLGTP+ Sbjct: 272 PGRDYHNQLWLIMEVLGTPN 291
>PMK1_CAEEL (Q17446) Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (p38| MAP kinase 1) (Stress-activated protein kinase pmk-1) Length = 377 Score = 123 bits (309), Expect = 4e-28 Identities = 68/168 (40%), Positives = 102/168 (60%), Gaps = 2/168 (1%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYT 284 +++ I+ + QIL+GL Y+H+ HRDLKP N+ V+ +KI DFGLAR+ S T Sbjct: 134 NDDHIQFLVYQILRGLKYIHSADIIHRDLKPSNIAVNEDCELKILDFGLARQTDSE--MT 191 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L YT ++D+W++G ILAEL T LFPG DQL +I +V G Sbjct: 192 GYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELITGKTLFPGSDHIDQLTRIMSVTG 251 Query: 465 TPDHSLWPE-GMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TPD + R+ ++ R+ L A+ +A+DL++++ Sbjct: 252 TPDEEFLKKISSEEARNYIRNLPKMTRRDFKRLFAQATPQAIDLLEKM 299
>CD2L7_CAEEL (P46551) Putative cell division cycle 2-related protein kinase 7| (EC 2.7.11.22) Length = 730 Score = 123 bits (309), Expect = 4e-28 Identities = 70/168 (41%), Positives = 101/168 (60%), Gaps = 6/168 (3%) Frame = +3 Query: 105 FSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLARE-VCSTPP 278 F++++I Q+L+GL Y+HN G+ HRD+K N+LV+N G +KIAD GLAR + Sbjct: 416 FNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESRL 475 Query: 279 YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAV 458 YT+ V T WYR PE+LL Y P+ID+W+ G +L ELFT PLF G E QL I V Sbjct: 476 YTNRVITLWYRPPELLLGDERYGPAIDVWSTGCMLGELFTRKPLFNGNNEFGQLELISKV 535 Query: 459 LGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWE----LIPNASLEALD 590 G+P+ WPE L ++F+ + R + E ++P +++ LD Sbjct: 536 CGSPNVDNWPELTELVGWNTFRMKRTYQRRIREEFEHIMPREAVDLLD 583
>CDK5_BOVIN (Q02399) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Proline-directed protein kinase 33 kDa subunit) (PDPK) Length = 292 Score = 123 bits (309), Expect = 4e-28 Identities = 69/167 (41%), Positives = 96/167 (57%), Gaps = 3/167 (1%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTD 287 E ++ F+ Q+L+GL + H+ HRDLKP+NLL++ NG +K+ADFGLAR Y+ Sbjct: 101 EIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA 160 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLS-PLFPGETETDQLFKICAVLG 464 V T WYR+P+VL A Y+ SIDMW+ G I AEL PLFPG DQL +I +LG Sbjct: 161 EVVTLWYRSPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG 220 Query: 465 TPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TP WP LP + + +L ++P + DL++ L Sbjct: 221 TPTEEQWPAMTKLPDYKPYPMYP-ATTSLVNVVPKLNATGRDLLQNL 266
>CDC2D_ANTMA (Q38775) Cell division control protein 2 homolog D (EC 2.7.11.22)| (EC 2.7.11.23) Length = 312 Score = 123 bits (308), Expect = 5e-28 Identities = 64/165 (38%), Positives = 95/165 (57%), Gaps = 3/165 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNG--IVKIADFGLARE-VCSTPPYTDY 290 ++ M Q+ +G+ + H +G HRDLKP NLL+ ++KIAD GLAR YT Sbjct: 122 VKSLMYQLCKGVAFCHGHGVLHRDLKPHNLLMDRKTMMLKIADLGLARAYTLPIKKYTHE 181 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + T WYRAPEVLL A+ Y+P++DMW++ I AEL T LFPG++E QL I +LGTP Sbjct: 182 ILTLWYRAPEVLLGATHYSPAVDMWSVACIFAELVTQKALFPGDSELQQLLHIFRLLGTP 241 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 + +WP L + + P + +P + L+L+ ++ Sbjct: 242 NEEIWPGVSTLVDWHEYPQWTAQP--ISSAVPGLDEKGLNLLSEM 284
>CDK5_HUMAN (Q00535) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 123 bits (308), Expect = 5e-28 Identities = 69/167 (41%), Positives = 95/167 (56%), Gaps = 3/167 (1%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTD 287 E ++ F+ Q+L+GL + H+ HRDLKP+NLL++ NG +K+ADFGLAR Y+ Sbjct: 101 EIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA 160 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLS-PLFPGETETDQLFKICAVLG 464 V T WYR P+VL A Y+ SIDMW+ G I AEL PLFPG DQL +I +LG Sbjct: 161 EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG 220 Query: 465 TPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TP WP LP + + +L ++P + DL++ L Sbjct: 221 TPTEEQWPSMTKLPDYKPYPMYP-ATTSLVNVVPKLNATGRDLLQNL 266
>CC2H2_TRYBB (P54665) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 345 Score = 122 bits (307), Expect = 6e-28 Identities = 66/182 (36%), Positives = 104/182 (57%), Gaps = 3/182 (1%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN--GIVKIAD 242 +L ++++R+ F ++R+ M Q+L GL H+ + HRD+KP N+L+ +VK+AD Sbjct: 128 DLQGMLKQRNTAFVGGKLRRIMFQLLLGLHECHSRRFVHRDIKPSNILIDRKESVVKLAD 187 Query: 243 FGLAREV-CSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPG 419 FGL R YT V T WYRAPEVLL Y P++D+W++G + AEL LF G Sbjct: 188 FGLGRAFRVPLQTYTTEVMTLWYRAPEVLLGDKQYLPAVDVWSMGCVFAELARRRSLFAG 247 Query: 420 ETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIK 599 +T +QLF I +LGTP + W +LP + F + + L +P + +DL++ Sbjct: 248 DTAINQLFSIFQLLGTPTEATWRGVTSLPH-HNVNFPRWTAKPLRTAVPALDDDGVDLLR 306 Query: 600 QL 605 ++ Sbjct: 307 RM 308
>BUR1_GIBZE (Q4I5U9) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 473 Score = 122 bits (307), Expect = 6e-28 Identities = 64/159 (40%), Positives = 94/159 (59%), Gaps = 13/159 (8%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ S F E +I+ +MLQ+L+GL Y+H++ HRD+K NLL++N GI++IADF Sbjct: 129 DLSGLLDNPSVQFKEPQIKCYMLQLLEGLRYLHDSRILHRDMKAANLLINNKGILQIADF 188 Query: 246 GLAREVCSTPP------------YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAE 389 GLAR P YT V TRWYR PE+LLQ YTP+ID+W +G + E Sbjct: 189 GLARHYDGRTPESGVPMGEGKRDYTGLVVTRWYRPPELLLQLRQYTPAIDVWGVGCVFGE 248 Query: 390 LFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLP 506 + P+ GE++ QL I ++G+P+ P +LP Sbjct: 249 MLYGKPILAGESDAAQLDIIWDLMGSPNEENMPRWKSLP 287
>CDK5_MOUSE (P49615) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6) Length = 292 Score = 122 bits (307), Expect = 6e-28 Identities = 69/167 (41%), Positives = 95/167 (56%), Gaps = 3/167 (1%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTD 287 E ++ F+ Q+L+GL + H+ HRDLKP+NLL++ NG +K+ADFGLAR Y+ Sbjct: 101 EIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA 160 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLS-PLFPGETETDQLFKICAVLG 464 V T WYR P+VL A Y+ SIDMW+ G I AEL PLFPG DQL +I +LG Sbjct: 161 EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG 220 Query: 465 TPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TP WP LP + + +L ++P + DL++ L Sbjct: 221 TPTEEQWPAMTKLPDYKPYPMYP-ATTSLVNVVPKLNATGRDLLQNL 266
>GSK3B_RAT (P18266) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) (Factor A) (FA) Length = 420 Score = 122 bits (306), Expect = 8e-28 Identities = 67/169 (39%), Positives = 102/169 (60%), Gaps = 4/169 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS--NGIVKIADFGLAREVCSTPPYTDYV 293 ++ +M Q+ + L Y+H+ G HRD+KP+NLL+ ++K+ DFG A+++ P Y+ Sbjct: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 +R+YRAPE++ A+ YT SIDMW+ G +LAEL P+FPG++ DQL +I VLGTP Sbjct: 218 CSRYYRAPELIFGATDYTSSIDMWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELI--PNASLEALDLIKQLCSW 614 E MN P + F+F QI + W + P EA+ L +L + Sbjct: 278 REQIRE-MN-PNYTEFKFPQI-KAHPWTKVFRPRTPPEAIALCSRLLEY 323
>GSK31_SCHPO (Q9URT9) Protein kinase gsk31 (EC 2.7.11.1)| Length = 381 Score = 122 bits (306), Expect = 8e-28 Identities = 67/180 (37%), Positives = 107/180 (59%), Gaps = 4/180 (2%) Frame = +3 Query: 87 RERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS--NGIVKIADFGLARE 260 R +S P I+ + Q+ + L Y+H+ G HRD+KP+NLLV GI+K+ DFG A+ Sbjct: 118 RRKSIP--NLSIKLYAFQLFRALAYLHSTGVCHRDIKPQNLLVDYKTGILKLCDFGSAKV 175 Query: 261 VCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQL 440 + + P Y+ +R+YRAPE++ A+ YT ID+W+ ++AELF PLFPG++ +QL Sbjct: 176 LVPSEPNVSYICSRYYRAPELVFGATHYTTKIDVWSAACVIAELFIGRPLFPGDSSVEQL 235 Query: 441 FKICAVLGTPD-HSLWPEGMNLPRSSSFQFFQIPPRNLWELIP-NASLEALDLIKQLCSW 614 +I VLGTP H + MN P + + P L ++P N + A+DL+ ++ ++ Sbjct: 236 VEIIRVLGTPSYHEI--SVMN-PNYVNHSLPNVRPHTLESVMPHNCTKNAMDLLHKMLTY 292
>CDKL2_RABIT (Q9TTK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 566 Score = 122 bits (306), Expect = 8e-28 Identities = 55/120 (45%), Positives = 86/120 (71%), Gaps = 2/120 (1%) Frame = +3 Query: 111 EEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP-YT 284 ++ ++K++ QI+ G+ + H++ HRD+KPEN+LVS +G+VK+ DFG AR + + YT Sbjct: 100 DQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYT 159 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 DYV+TRWYRAPE+L+ Y ++D+WAIG ++ E+ PLFPG+++ DQL+ I LG Sbjct: 160 DYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMLMGEPLFPGDSDIDQLYLIMRCLG 219
>MK13_MOUSE (Q9Z1B7) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 366 Score = 122 bits (306), Expect = 8e-28 Identities = 69/169 (40%), Positives = 100/169 (59%), Gaps = 2/169 (1%) Frame = +3 Query: 105 FSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPY 281 FSE++++ + Q+L+GL Y+H+ G HRDLKP NL V+ +KI DFGLAR + Sbjct: 122 FSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARH--TDTEM 179 Query: 282 TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVL 461 T YV TRWYRAPEV+L Y ++D+W++G I+AE+ T LF G+ DQL +I V Sbjct: 180 TGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVT 239 Query: 462 GTPDHSLWPEGMNLPRSSSFQFF-QIPPRNLWELIPNASLEALDLIKQL 605 G P + + S Q Q P ++ +L P AS +A DL+ ++ Sbjct: 240 GVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKM 288
>BUR1_YARLI (Q6C842) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 706 Score = 122 bits (305), Expect = 1e-27 Identities = 71/192 (36%), Positives = 102/192 (53%), Gaps = 13/192 (6%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ +S S I+ +MLQ+L+G+ Y+H + HRD+K N+LV++ GI+K+ADF Sbjct: 128 DLAGLLGNQSVQLSPAHIKCYMLQLLEGIGYLHAKKFLHRDIKAANILVNDQGILKLADF 187 Query: 246 GLAREVCSTPP-----------YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAEL 392 GLAR P T V TRWYR PE++L YT +IDMW IG + E Sbjct: 188 GLARGYDGPAPNSQTAGVNTENLTAMVVTRWYRPPELILGDRKYTTAIDMWGIGCVFGEF 247 Query: 393 FTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRN-LWELIPN 569 FT P+FPG ++ DQ KI +G P P LP + + + N L +L Sbjct: 248 FTRKPIFPGASDVDQGSKIFQAVGVPTEDTMPGWSVLPGAQNSNIWGTDATNKLDKLFGR 307 Query: 570 ASLEALDLIKQL 605 S + LD +K L Sbjct: 308 LSKDGLDFLKGL 319
>GSK3A_RAT (P18265) Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3| alpha) (Factor A) (FA) Length = 483 Score = 122 bits (305), Expect = 1e-27 Identities = 61/141 (43%), Positives = 91/141 (64%), Gaps = 2/141 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS--NGIVKIADFGLAREVCSTPPYTDYV 293 ++ +M Q+ + L Y+H+ G HRD+KP+NLLV ++K+ DFG A+++ P Y+ Sbjct: 221 VKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYI 280 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 +R+YRAPE++ A+ YT SID+W+ G +LAEL P+FPG++ DQL +I VLGTP Sbjct: 281 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 340 Query: 474 HSLWPEGMNLPRSSSFQFFQI 536 E MN P + F+F QI Sbjct: 341 REQIRE-MN-PNYTEFKFPQI 359
>GSK3A_HUMAN (P49840) Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3| alpha) Length = 483 Score = 122 bits (305), Expect = 1e-27 Identities = 61/141 (43%), Positives = 91/141 (64%), Gaps = 2/141 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS--NGIVKIADFGLAREVCSTPPYTDYV 293 ++ +M Q+ + L Y+H+ G HRD+KP+NLLV ++K+ DFG A+++ P Y+ Sbjct: 221 VKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYI 280 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 +R+YRAPE++ A+ YT SID+W+ G +LAEL P+FPG++ DQL +I VLGTP Sbjct: 281 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 340 Query: 474 HSLWPEGMNLPRSSSFQFFQI 536 E MN P + F+F QI Sbjct: 341 REQIRE-MN-PNYTEFKFPQI 359
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 122 bits (305), Expect = 1e-27 Identities = 67/162 (41%), Positives = 96/162 (59%), Gaps = 5/162 (3%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ F Q+LQG+ + H N HRDLKP+NLL++N G +K+ DFGLAR ++ V Sbjct: 110 VKYFQWQLLQGVAFCHENRILHRDLKPQNLLINNRGQLKLGDFGLARAFGIPVNTFSSEV 169 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAP+VL+ + Y SID+W+ G ILAE+ PLFPG + +QL I +GTP Sbjct: 170 VTLWYRAPDVLMGSRNYCTSIDIWSCGCILAEMIMGKPLFPGSNDEEQLKLIFDTMGTPV 229 Query: 474 HSLWPEGMNLPRSSSFQFFQIP---PRNLWELIPNASLEALD 590 WP+ L + + +P PR+L +L+ N + E LD Sbjct: 230 EQTWPQVTQLAKYNPL----LPPHMPRDLKQLLQNNTEEVLD 267
>CDKL4_HUMAN (Q5MAI5) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 315 Score = 122 bits (305), Expect = 1e-27 Identities = 61/135 (45%), Positives = 88/135 (65%), Gaps = 1/135 (0%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREVCSTPPYTDYVS 296 I+ + Q LQ L + H + HRD+KPEN+L++ GI+KI DFG A+ + YTDYV+ Sbjct: 103 IKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVA 162 Query: 297 TRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDH 476 TRWYRAPE+L+ + Y S+D+WAIG + AEL T PL+PG+++ DQL+ I LG Sbjct: 163 TRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG---- 218 Query: 477 SLWPEGMNLPRSSSF 521 L P ++ +S+ F Sbjct: 219 KLIPRHQSIFKSNGF 233
>BUR1_NEUCR (Q871M9) Serine/threonine-protein kinase bur-1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 545 Score = 121 bits (304), Expect = 1e-27 Identities = 68/192 (35%), Positives = 102/192 (53%), Gaps = 13/192 (6%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ S F+E +++ ++LQ+L+GL Y+H N HRD+K NLL++N G+++IADF Sbjct: 117 DLSGLLDNPSVRFTEPQVKCYLLQLLEGLKYLHANHILHRDMKAANLLINNKGVLQIADF 176 Query: 246 GLAREVCSTPP------------YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAE 389 GLAR P YT V TRWYR PE+L+ YT +IDMW +G + AE Sbjct: 177 GLARHYEGDIPQPGKGSGEGKRDYTSLVVTRWYRPPELLMHLKRYTTAIDMWGVGCVFAE 236 Query: 390 LFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPN 569 + P+ GE++ QL + + GTP P LP +F + P NL Sbjct: 237 MLEGKPVLQGESDLHQLELVWDLCGTPSEETMPGWRTLPGGQAFS-SKPRPGNLARRFEK 295 Query: 570 ASLEALDLIKQL 605 + L+K+L Sbjct: 296 HGPVVISLLKEL 307
>CDKL2_MOUSE (Q9QUK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 568 Score = 121 bits (304), Expect = 1e-27 Identities = 56/117 (47%), Positives = 83/117 (70%), Gaps = 2/117 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP-YTDYV 293 ++K++ QI+ G+ + H++ HRD+KPEN+LVS +G+VK+ DFG AR + + YTDYV Sbjct: 103 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYV 162 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 +TRWYRAPE+L+ Y ++D+WAIG ++ E+ PLFPGE++ DQL I LG Sbjct: 163 ATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLG 219
>CDKL2_RAT (Q5XIT0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 507 Score = 121 bits (304), Expect = 1e-27 Identities = 56/117 (47%), Positives = 83/117 (70%), Gaps = 2/117 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP-YTDYV 293 ++K++ QI+ G+ + H++ HRD+KPEN+LVS +G+VK+ DFG AR + + YTDYV Sbjct: 103 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYV 162 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 +TRWYRAPE+L+ Y ++D+WAIG ++ E+ PLFPGE++ DQL I LG Sbjct: 163 ATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLG 219
>CDC2B_ARATH (P25859) Cell division control protein 2 homolog B (EC 2.7.11.22)| (EC 2.7.11.23) Length = 309 Score = 121 bits (304), Expect = 1e-27 Identities = 64/168 (38%), Positives = 99/168 (58%), Gaps = 3/168 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLV--SNGIVKIADFGLARE-VCSTPPYTDY 290 I+K M Q+ +G+ + H++G HRDLKP+NLL+ ++KIAD GL R YT Sbjct: 119 IQKLMFQLCKGVAHCHSHGVLHRDLKPQNLLLVKDKELLKIADLGLGRAFTVPLKSYTHE 178 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + T WYRAPEVLL ++ Y+ +DMW++G I AE+ LFPG++E QL I +LGTP Sbjct: 179 IVTLWYRAPEVLLGSTHYSTGVDMWSVGCIFAEMVRRQALFPGDSEFQQLLHIFRLLGTP 238 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQLCSW 614 WP L + ++ P++L +P+ S + +DL+ ++ + Sbjct: 239 TEQQWPGVSTLRDWHVYPKWE--PQDLTLAVPSLSPQGVDLLTKMLKY 284
>PCTK1_RAT (Q63686) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 121 bits (304), Expect = 1e-27 Identities = 63/164 (38%), Positives = 94/164 (57%), Gaps = 2/164 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLA-REVCSTPPYTDYV 293 ++ F+ Q+L+GL Y H HRDLKP+NLL++ G +K+ADFGLA + T Y++ V Sbjct: 263 VKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLAYAKSIPTKTYSNEV 322 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR P++LL ++ Y+ IDMW +G I E+ T PLFPG T +QL I +LGTP Sbjct: 323 VTLWYRPPDILLGSTDYSGQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPT 382 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 WP ++ ++ + + L P + DL+ +L Sbjct: 383 EDTWPGILSNEEFRTYNYPKYRAEALLRHAPRLECDGADLLTKL 426
>BUR1_CANGA (Q6FQ83) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 667 Score = 121 bits (303), Expect = 2e-27 Identities = 59/144 (40%), Positives = 86/144 (59%), Gaps = 14/144 (9%) Frame = +3 Query: 117 EIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP----- 278 +I+ M QIL+G+ ++H + + HRD+K NLL+ NG++K+ADFGLAR+ +PP Sbjct: 183 DIKNMMKQILEGVNFIHCSKFMHRDIKTANLLIDHNGVLKLADFGLARQYYGSPPNIKFP 242 Query: 279 --------YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETD 434 YT V TRWYRAPE++L YT ++D+W +G + AE F P+ G+T+ D Sbjct: 243 GSAGSGAKYTSVVVTRWYRAPELVLGDKYYTTAVDIWGVGCVFAEFFEKKPILQGKTDID 302 Query: 435 QLFKICAVLGTPDHSLWPEGMNLP 506 Q I ++GTPD W LP Sbjct: 303 QGHVIFKLMGTPDERTWELAKYLP 326
>CTK1_YEAST (Q03957) CTD kinase subunit alpha (EC 2.7.11.23) (CTD kinase 58 kDa| subunit) (CTDK-I alpha subunit) Length = 528 Score = 121 bits (303), Expect = 2e-27 Identities = 62/170 (36%), Positives = 95/170 (55%), Gaps = 1/170 (0%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADF 245 +L ++ + S + + Q+L G+ Y+H+N HRD+K N+L+ N G +KI DF Sbjct: 266 DLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNLKITDF 325 Query: 246 GLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET 425 GLAR++ S YT+ V T WYR PE+LL + Y +DMW G +L ELF + +F G Sbjct: 326 GLARKMNSRADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELFNKTAIFQGSN 385 Query: 426 ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNAS 575 E +Q+ I ++GTP + WP ++P FF I P+ + + N S Sbjct: 386 ELEQIESIFKIMGTPTINSWPTLYDMP-----WFFMIMPQQTTKYVNNFS 430
>CDK2_ENTHI (Q04770) Cell division protein kinase 2 homolog (EC 2.7.11.22)| Length = 291 Score = 121 bits (303), Expect = 2e-27 Identities = 63/140 (45%), Positives = 84/140 (60%), Gaps = 2/140 (1%) Frame = +3 Query: 93 RSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAR-EVC 266 RS+ E R + QILQGL + H + HRD+KP+N+L++ NG +K+ +FGLAR Sbjct: 93 RSSKIPINETRSIVYQILQGLAFCHYHQILHRDMKPQNILINKNGTIKLGEFGLARLTTI 152 Query: 267 STPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFK 446 + YT V T WYRAPE+LL A+ Y +ID+W+ AI EL LF G + DQLFK Sbjct: 153 NDRKYTSEVVTLWYRAPEILLGATQYGGAIDIWSTAAIFGELINKEELFKGRCKIDQLFK 212 Query: 447 ICAVLGTPDHSLWPEGMNLP 506 I + LGTP +W LP Sbjct: 213 IFSQLGTPTEDIWNGVTKLP 232
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 120 bits (302), Expect = 2e-27 Identities = 63/146 (43%), Positives = 92/146 (63%), Gaps = 2/146 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYV 293 ++ F Q+L+GL + H N HRDLKP+NLL++ G +K+ DFGLAR ++ V Sbjct: 109 VKYFQWQLLEGLAFCHENKILHRDLKPQNLLITKRGQLKLGDFGLARAFGIPVNTFSSEV 168 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYRAP+VL+ + Y+ SID+W+ G ILAE+ T PLFPG + +QL I +GTP+ Sbjct: 169 VTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDKMGTPN 228 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNL 551 + WP +LP+ + F Q P++L Sbjct: 229 ETTWPGVTSLPKYNP-NFQQRLPKDL 253
>GSK3B_MOUSE (Q9WV60) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 120 bits (302), Expect = 2e-27 Identities = 66/169 (39%), Positives = 102/169 (60%), Gaps = 4/169 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS--NGIVKIADFGLAREVCSTPPYTDYV 293 ++ +M Q+ + L Y+H+ G HRD+KP+NLL+ ++K+ DFG A+++ P Y+ Sbjct: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 +R+YRAPE++ A+ YT SID+W+ G +LAEL P+FPG++ DQL +I VLGTP Sbjct: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELI--PNASLEALDLIKQLCSW 614 E MN P + F+F QI + W + P EA+ L +L + Sbjct: 278 REQIRE-MN-PNYTEFKFPQI-KAHPWTKVFRPRTPPEAIALCSRLLEY 323
>GSK3B_HUMAN (P49841) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 120 bits (302), Expect = 2e-27 Identities = 66/169 (39%), Positives = 102/169 (60%), Gaps = 4/169 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS--NGIVKIADFGLAREVCSTPPYTDYV 293 ++ +M Q+ + L Y+H+ G HRD+KP+NLL+ ++K+ DFG A+++ P Y+ Sbjct: 158 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 217 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 +R+YRAPE++ A+ YT SID+W+ G +LAEL P+FPG++ DQL +I VLGTP Sbjct: 218 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 277 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELI--PNASLEALDLIKQLCSW 614 E MN P + F+F QI + W + P EA+ L +L + Sbjct: 278 REQIRE-MN-PNYTEFKFPQI-KAHPWTKVFRPRTPPEAIALCSRLLEY 323
>CDK5_RAT (Q03114) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 120 bits (301), Expect = 3e-27 Identities = 68/167 (40%), Positives = 94/167 (56%), Gaps = 3/167 (1%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV-CSTPPYTD 287 E ++ + Q+L+GL + H+ HRDLKP+NLL++ NG +K+ADFGLAR Y+ Sbjct: 101 EIVKSLLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA 160 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLS-PLFPGETETDQLFKICAVLG 464 V T WYR P+VL A Y+ SIDMW+ G I AEL PLFPG DQL +I +LG Sbjct: 161 EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG 220 Query: 465 TPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TP WP LP + + +L ++P + DL++ L Sbjct: 221 TPTEEQWPAMTKLPDYKPYPMYP-ATTSLVNVVPKLNATGRDLLQNL 266
>CDKL3_MOUSE (Q8BLF2) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| Length = 595 Score = 120 bits (300), Expect = 4e-27 Identities = 55/119 (46%), Positives = 83/119 (69%), Gaps = 2/119 (1%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP-YTD 287 + +RK++ QIL+ + Y+HNN HRD+KPEN+LVS +GI K+ DFG AR + + YTD Sbjct: 100 KRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTD 159 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L+ ++Y +D+WA+G ++ E+ T P P ++ D L KI +G Sbjct: 160 YVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVG 218
>CDKL3_RAT (Q9JM01) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| (Serine/threonine protein kinase NKIATRE) Length = 593 Score = 120 bits (300), Expect = 4e-27 Identities = 55/119 (46%), Positives = 83/119 (69%), Gaps = 2/119 (1%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP-YTD 287 + +RK++ QIL+ + Y+HNN HRD+KPEN+LVS +GI K+ DFG AR + + YTD Sbjct: 100 KRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTD 159 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L+ + Y +D+WA+G ++ E+ T +P P ++ D L KI +G Sbjct: 160 YVATRWYRAPELVLKDTTYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVG 218
>ERK1_DICDI (P42525) Extracellular signal-regulated kinase 1 (EC 2.7.11.24)| (ERK1) (MAP kinase 1) Length = 415 Score = 119 bits (299), Expect = 5e-27 Identities = 66/177 (37%), Positives = 104/177 (58%), Gaps = 9/177 (5%) Frame = +3 Query: 102 PFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNG-IVKIADFGLAREVCSTPP 278 P S++ + F+ Q+L+GL ++H+ HRDLKP NLL++ ++KI D GLAR +T Sbjct: 128 PLSDDHCQYFVYQMLRGLKHIHSANVLHRDLKPSNLLINEDCLLKICDLGLARVEDATHQ 187 Query: 279 --YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKIC 452 T+YV+TRWYRAPEV+L + YT +ID+W++G I AEL PLF G+ Q+ I Sbjct: 188 GFMTEYVATRWYRAPEVILSWNKYTKAIDIWSVGCIFAELLGRKPLFQGKDYIHQITLII 247 Query: 453 AVLGTPDHSLWPEGMNLPRSSSFQFFQI------PPRNLWELIPNASLEALDLIKQL 605 +G+P + N+ + QF + P N + P A+ +A+DL++++ Sbjct: 248 ETIGSPSEE---DICNIANEQARQFIRSLNMGNQPKVNFANMFPKANPDAIDLLERM 301
>BUR1_DEBHA (Q6BV06) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 608 Score = 119 bits (299), Expect = 5e-27 Identities = 64/170 (37%), Positives = 93/170 (54%), Gaps = 14/170 (8%) Frame = +3 Query: 39 CSSFLNTWXCN-LYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV 215 C ++ + C+ L ++ + I+ FM Q+L G+ Y+H + HRD+K N+L+ Sbjct: 123 CFYTVSPYMCSDLVGLLENPNINLEVSHIKCFMEQLLHGIQYIHEQMFLHRDIKAANILI 182 Query: 216 S-NGIVKIADFGLAREVCSTPP------------YTDYVSTRWYRAPEVLLQASAYTPSI 356 NG +KIADFGLAR +PP YT V TRWYR PE+LL YT ++ Sbjct: 183 DRNGTLKIADFGLARVYHGSPPKFMSGPGGGERAYTGLVVTRWYRPPELLLGERRYTTAV 242 Query: 357 DMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLP 506 DMW IG + ELFT P+ G+T++ Q I ++G P+ W E +LP Sbjct: 243 DMWGIGCVFGELFTRKPILVGKTDSHQAQLIFDLVGPPNSISWSEATSLP 292
>BUR1_ASHGO (Q75D46) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 753 Score = 119 bits (299), Expect = 5e-27 Identities = 62/144 (43%), Positives = 84/144 (58%), Gaps = 14/144 (9%) Frame = +3 Query: 117 EIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAREVCSTPP----- 278 +I+ MLQIL+G+ Y+H + HRD+K N+L+ + GI+KIADFGLAR PP Sbjct: 177 DIKNMMLQILEGINYIHCKKFMHRDIKTANILLDHKGILKIADFGLARNYYGAPPNLKYP 236 Query: 279 --------YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETD 434 YT V TRWYRAPE++L YT ++D+W IG + AE F P+ G+T+ D Sbjct: 237 GGAGTDAKYTSVVVTRWYRAPELVLGDKNYTTAVDIWGIGCVFAEFFEKRPILQGKTDID 296 Query: 435 QLFKICAVLGTPDHSLWPEGMNLP 506 Q I ++GTP S W LP Sbjct: 297 QGHVIFKLMGTPSDSDWQLARYLP 320
>BUR1_YEAST (P23293) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) (Suppressor of GPA1-Vall50 mutation protein 1) (Bypass UAS requirement protein 1) Length = 657 Score = 119 bits (299), Expect = 5e-27 Identities = 61/144 (42%), Positives = 83/144 (57%), Gaps = 14/144 (9%) Frame = +3 Query: 117 EIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP----- 278 +I+ MLQIL+GL Y+H + HRD+K N+L+ NG++K+ADFGLAR PP Sbjct: 171 DIKNMMLQILEGLNYIHCAKFMHRDIKTANILIDHNGVLKLADFGLARLYYGCPPNLKYP 230 Query: 279 --------YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETD 434 YT V TRWYRAPE++L YT ++D+W +G + AE F P+ G+T+ D Sbjct: 231 GGAGSGAKYTSVVVTRWYRAPELVLGDKQYTTAVDIWGVGCVFAEFFEKKPILQGKTDID 290 Query: 435 QLFKICAVLGTPDHSLWPEGMNLP 506 Q I +LGTP W LP Sbjct: 291 QGHVIFKLLGTPTEEDWAVARYLP 314
>MK14_XENLA (P47812) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated Mitogen-activated protein kinase 2) (MAP kinase 2) (MPK2) Length = 361 Score = 119 bits (298), Expect = 7e-27 Identities = 65/168 (38%), Positives = 101/168 (60%), Gaps = 2/168 (1%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYT 284 +++ ++ + QIL+GL Y+H+ G HRDLKP NL V+ +KI DFGLAR + T Sbjct: 124 TDDHVQFLIYQILRGLKYIHSAGIIHRDLKPSNLAVNEDCELKILDFGLARH--TDEEMT 181 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L Y ++D+W++G I+AEL T LFPG DQL I ++G Sbjct: 182 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 241 Query: 465 TPDHSLWPE-GMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TP+ L + R+ +P N ++ A+ +A+DL++++ Sbjct: 242 TPEPELLQKISSEAARNYIQSLPYMPKMNFEDVFLGANPQAVDLLEKM 289
>MK14A_CYPCA (Q90336) Mitogen-activated protein kinase 14a (EC 2.7.11.24)| (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (cp38a) Length = 361 Score = 119 bits (298), Expect = 7e-27 Identities = 67/171 (39%), Positives = 103/171 (60%), Gaps = 5/171 (2%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYT 284 +++ ++ + QIL+GL Y+H+ HRDLKP NL V+ +KI DFGLAR + T Sbjct: 124 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMT 181 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L Y ++D+W++G I+AEL T LFPG +QL +I + G Sbjct: 182 GYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 241 Query: 465 TPDHSLWPEGMNLPRSSSFQFF----QIPPRNLWELIPNASLEALDLIKQL 605 TP SL +P + + Q+P RN E+ A+ +A+DL++++ Sbjct: 242 TPPASLI---SRMPSHEARTYINSLPQMPKRNFSEVFIGANPQAVDLLEKM 289
>SGG_DROME (P18431) Protein kinase shaggy (EC 2.7.11.1) (Protein zeste-white 3)| Length = 1067 Score = 119 bits (297), Expect = 9e-27 Identities = 65/169 (38%), Positives = 101/169 (59%), Gaps = 4/169 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS--NGIVKIADFGLAREVCSTPPYTDYV 293 IR +M Q+ + L Y+H+ G HRD+KP+NLL+ ++K+ DFG A+++ P Y+ Sbjct: 709 IRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYI 768 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 +R+YRAPE++ A YT ID+W+ G +LAEL P+FPG++ DQL ++ VLGTP Sbjct: 769 CSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPT 828 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELI--PNASLEALDLIKQLCSW 614 E MN P + F+F QI + W+ + EA++L+ L + Sbjct: 829 REQIRE-MN-PNYTEFKFPQI-KSHPWQKVFRIRTPTEAINLVSLLLEY 874
>KSG7_ARATH (Q39011) Shaggy-related protein kinase eta (EC 2.7.11.1) (ASK-eta)| (BRASSINOSTEROID-INSENSITIVE 2) (ULTRACURVATA1) Length = 380 Score = 118 bits (296), Expect = 1e-26 Identities = 73/170 (42%), Positives = 100/170 (58%), Gaps = 5/170 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHN-NGYFHRDLKPENLLVS--NGIVKIADFGLAREVCSTPPYTDY 290 ++ +M QI +GL Y+HN G HRDLKP+NLLV VKI DFG A+++ Y Sbjct: 141 VKLYMYQIFRGLAYIHNVAGVCHRDLKPQNLLVDPLTHQVKICDFGSAKQLVKGEANISY 200 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ A+ YT SID+W+ G +LAEL PLFPGE DQL +I VLGTP Sbjct: 201 ICSRFYRAPELIFGATEYTTSIDIWSAGCVLAELLLGQPLFPGENAVDQLVEIIKVLGTP 260 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASL--EALDLIKQLCSW 614 MN P + F+F QI + W I + + EA+D +L + Sbjct: 261 TRE-EIRCMN-PHYTDFRFPQI-KAHPWHKIFHKRMPPEAIDFASRLLQY 307
>MK14A_BRARE (Q9DGE2) Mitogen-activated protein kinase 14a (EC 2.7.11.24)| (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (zp38a) Length = 361 Score = 118 bits (296), Expect = 1e-26 Identities = 66/168 (39%), Positives = 102/168 (60%), Gaps = 2/168 (1%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYT 284 +++ ++ + QIL+GL Y+H+ HRDLKP NL V+ +KI DFGLAR + T Sbjct: 124 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMT 181 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L Y ++D+W++G I+AEL T LFPG +QL +I + G Sbjct: 182 GYVATRWYRAPEIMLNWMHYNVTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 241 Query: 465 TPDHSLWPE-GMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TP SL + R+ Q+P RN ++ A+ +A+DL++++ Sbjct: 242 TPPSSLISRMPSHEARTYISSLPQMPKRNFADVFIGANPQAVDLLEKM 289
>KSG10_ARATH (Q39019) Shaggy-related protein kinase kappa (EC 2.7.11.1)| (ASK-kappa) (AtK-1) Length = 421 Score = 118 bits (295), Expect = 2e-26 Identities = 70/164 (42%), Positives = 101/164 (61%), Gaps = 5/164 (3%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNN-GYFHRDLKPENLLVSNGI--VKIADFGLAREVCSTPPYTDY 290 ++ + QI + L Y+HN+ G HRD+KP+NLLV+ +KI DFG A+ + P Y Sbjct: 184 VKLYTYQICRALAYIHNSFGLCHRDIKPQNLLVNPHTHQLKICDFGSAKVLVKGEPNVSY 243 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ AS YT +ID+W+ G ++AEL PLFPGE+ DQL +I VLGTP Sbjct: 244 ICSRYYRAPELIFGASEYTTAIDIWSTGCVMAELLLGQPLFPGESGVDQLVEIIKVLGTP 303 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASL--EALDLI 596 + MN P + F+F QI P + W + L EA+DL+ Sbjct: 304 TRE-EIKCMN-PNYTEFKFPQIKP-HPWHKVFQKRLPPEAVDLL 344
>STY1_SCHPO (Q09892) Mitogen-activated protein kinase sty1 (EC 2.7.11.24) (MAP| kinase sty1) (MAP kinase spc1) Length = 349 Score = 118 bits (295), Expect = 2e-26 Identities = 68/175 (38%), Positives = 100/175 (57%), Gaps = 5/175 (2%) Frame = +3 Query: 96 SAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCST 272 S P + I+ F+ QIL+GL ++H+ G HRDLKP N+L++ N +KI DFGLAR Sbjct: 110 SRPLETQFIQYFLYQILRGLKFVHSAGVIHRDLKPSNILINENCDLKICDFGLAR--IQD 167 Query: 273 PPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKIC 452 P T YVSTR+YRAPE++L Y +D+W+ G I AE+ PLFPG +Q I Sbjct: 168 PQMTGYVSTRYYRAPEIMLTWQKYNVEVDIWSAGCIFAEMIEGKPLFPGRDHVNQFSIIT 227 Query: 453 AVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRN----LWELIPNASLEALDLIKQL 605 +LGTP + + ++ +F Q P+ E NA +A+DL++++ Sbjct: 228 ELLGTPPMEVIE---TICSKNTLRFVQSLPQKEKVPFAEKFKNADPDAIDLLEKM 279
>CDKL3_HUMAN (Q8IVW4) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| (Serine/threonine protein kinase NKIAMRE) Length = 592 Score = 118 bits (295), Expect = 2e-26 Identities = 54/119 (45%), Positives = 84/119 (70%), Gaps = 2/119 (1%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP-YTD 287 + +RK++ QIL+ + Y+H+N HRD+KPEN+LVS +GI K+ DFG AR + + YTD Sbjct: 100 KRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTD 159 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L+ ++Y +D+WA+G ++ E+ T +P P ++ D L KI +G Sbjct: 160 YVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVG 218
>MK12_RAT (Q63538) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 118 bits (295), Expect = 2e-26 Identities = 69/172 (40%), Positives = 105/172 (61%), Gaps = 6/172 (3%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYT 284 SE+ I+ + Q+L+GL Y+H G HRDLKP NL V+ +KI DFGLAR+ S T Sbjct: 126 SEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MT 183 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV TRWYRAPEV+L YT ++D+W++G I+AE+ T LF G DQL +I V G Sbjct: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKVTG 243 Query: 465 TPDHSLWPEGMNLPRSSSFQFF-----QIPPRNLWELIPNASLEALDLIKQL 605 TP PE + +S+ + + ++ ++ ++ NAS +A++L++++ Sbjct: 244 TPP----PEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLEKM 291
>CDKL3_MACFA (Q4R8T9) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| Length = 590 Score = 118 bits (295), Expect = 2e-26 Identities = 54/119 (45%), Positives = 84/119 (70%), Gaps = 2/119 (1%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP-YTD 287 + +RK++ QIL+ + Y+H+N HRD+KPEN+LVS +GI K+ DFG AR + + YTD Sbjct: 100 KRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTD 159 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L+ ++Y +D+WA+G ++ E+ T +P P ++ D L KI +G Sbjct: 160 YVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVG 218
>PRK1_SCHPO (O13958) Serine/threonine-protein kinase prk1 (EC 2.7.11.22)| (Suppressor of RNA polymerase B srb10) Length = 352 Score = 117 bits (294), Expect = 2e-26 Identities = 69/197 (35%), Positives = 102/197 (51%), Gaps = 21/197 (10%) Frame = +3 Query: 87 RERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREV 263 R R+ ++ + QI+ G+ Y+H N HRDLKP N++++ G VKI D GL R + Sbjct: 106 RSRTRQIPPSILKSILWQIINGVAYLHENWIMHRDLKPANIMITATGKVKIGDLGLGRLI 165 Query: 264 CST--PPYTD--YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET-- 425 P Y+ V T WYRAPE+LL A YTP+ID+WAIG I E+ LSPLF G+ Sbjct: 166 RDPILPFYSSDRVVVTIWYRAPELLLGAHDYTPAIDVWAIGCIYGEMLALSPLFKGDEIK 225 Query: 426 ---------ETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRN-----LWELI 563 ++ Q+ +I +LGTP WP N P F++ N ++ + Sbjct: 226 MEDKKVVPFQSTQMLRIMELLGTPTEERWPGLKNYPEYYQLSSFEVRYWNNLLPQWYQTV 285 Query: 564 PNASLEALDLIKQLCSW 614 N + LDL+ ++ + Sbjct: 286 KNRDPQGLDLLMKMLQY 302
>SPM1_SCHPO (Q92398) Mitogen-activated protein kinase spm1 (EC 2.7.11.24) (MAP| kinase spm1) (MAP kinase pmk1) Length = 422 Score = 117 bits (294), Expect = 2e-26 Identities = 77/190 (40%), Positives = 106/190 (55%), Gaps = 11/190 (5%) Frame = +3 Query: 78 DVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLA 254 + I + P ++ + F+ QIL GL Y+H+ HRDLKP NLLV+ +KI DFGLA Sbjct: 112 NAIIKSGQPLTDAHFQSFIYQILCGLKYIHSANVIHRDLKPGNLLVNADCELKICDFGLA 171 Query: 255 REVCSTPP-----YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPG 419 R P T+YV+TRWYRAPE++L S+Y ID+W++G ILAEL +PLF G Sbjct: 172 RGCSENPEENPGFMTEYVATRWYRAPEIMLSFSSYHKGIDVWSVGCILAELLGGTPLFKG 231 Query: 420 ETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFF--QIP---PRNLWELIPNASLEA 584 + QL I LGTPD E ++ SS Q + +P P P A+ A Sbjct: 232 KDFVHQLNLILHQLGTPDE----ETLSHISSSRAQEYVRSLPKQRPIPFETNFPKANPLA 287 Query: 585 LDLIKQLCSW 614 LDL+ +L ++ Sbjct: 288 LDLLAKLLAF 297
>MAPK_FUSSO (Q00859) Mitogen-activated protein kinase (EC 2.7.11.24) (FsMAPK)| Length = 355 Score = 117 bits (294), Expect = 2e-26 Identities = 74/184 (40%), Positives = 106/184 (57%), Gaps = 10/184 (5%) Frame = +3 Query: 93 RSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCS 269 R+ S++ + F+ Q L+ L MH+ HRDLKP NLL++ N +K+ DFGLAR S Sbjct: 115 RTQDLSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAAS 174 Query: 270 TPP----YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQ 437 T+YV+TRWYRAPE++L YT +ID+W++G ILAE+ + PLFPG+ Q Sbjct: 175 QEDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQ 234 Query: 438 LFKICAVLGTPDHSLW-----PEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQ 602 L I VLGTP + RS F+ ++P R L+ P S ALDL+++ Sbjct: 235 LTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFK-KKVPFRTLF---PKTSDLALDLLEK 290 Query: 603 LCSW 614 L ++ Sbjct: 291 LLAF 294
>MK12_MOUSE (O08911) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 117 bits (294), Expect = 2e-26 Identities = 68/172 (39%), Positives = 105/172 (61%), Gaps = 6/172 (3%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYT 284 SE+ I+ + Q+L+GL Y+H G HRDLKP NL V+ +KI DFGLAR+ S T Sbjct: 126 SEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MT 183 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV TRWYRAPEV+L YT ++D+W++G I+AE+ T LF G DQL +I + G Sbjct: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKITG 243 Query: 465 TPDHSLWPEGMNLPRSSSFQFF-----QIPPRNLWELIPNASLEALDLIKQL 605 TP PE + +S+ + + ++ ++ ++ NAS +A++L++++ Sbjct: 244 TPP----PEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLERM 291
>UME5_YEAST (P39073) Meiotic mRNA stability protein kinase UME5 (EC 2.7.11.23)| Length = 541 Score = 117 bits (294), Expect = 2e-26 Identities = 64/139 (46%), Positives = 85/139 (61%), Gaps = 16/139 (11%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP--YTD- 287 +R M Q+L G+ Y+H N HRDLKP N++V+ +G VKI D GLAR+ + YT Sbjct: 249 VRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHNMLQTLYTGD 308 Query: 288 -YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGET-----------ET 431 V T WYRAPE+LL A YTP++D+W++G I AEL L P+F GE + Sbjct: 309 KVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTVPFQV 368 Query: 432 DQLFKICAVLGTPDHSLWP 488 +QL +I VLGTPD +WP Sbjct: 369 NQLQRILEVLGTPDQKIWP 387
>KSG4_ARATH (Q9FVS6) Shaggy-related protein kinase delta (EC 2.7.11.1)| (ASK-delta) Length = 420 Score = 117 bits (294), Expect = 2e-26 Identities = 70/164 (42%), Positives = 101/164 (61%), Gaps = 5/164 (3%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNN-GYFHRDLKPENLLVSNGI--VKIADFGLAREVCSTPPYTDY 290 ++ + QI +GL Y+HN G HRD+KP+NLLV+ +KI DFG A+ + P Y Sbjct: 183 VKLYTYQICRGLAYLHNCCGLCHRDIKPQNLLVNPHTHQLKICDFGSAKVLVKGEPNISY 242 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ A+ YT +ID+W+ G ++AEL PLFPGE+ DQL +I VLGTP Sbjct: 243 ICSRYYRAPELIFGATEYTTAIDIWSTGCVMAELLLGQPLFPGESGVDQLVEIIKVLGTP 302 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASL--EALDLI 596 + MN P + F+F QI P + W + L EA+DL+ Sbjct: 303 TRE-EIKCMN-PNYTEFKFPQIKP-HPWHKVFQKRLPPEAVDLL 343
>CDC2C_ANTMA (Q38774) Cell division control protein 2 homolog C (EC 2.7.11.22)| (EC 2.7.11.23) Length = 305 Score = 117 bits (293), Expect = 3e-26 Identities = 66/168 (39%), Positives = 97/168 (57%), Gaps = 3/168 (1%) Frame = +3 Query: 102 PFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN--GIVKIADFGLARE-VCST 272 P ++I+ F+ Q+ +G+ + H +G HRDLKP+NLL+ G++KIAD GLAR Sbjct: 109 PLPPQQIQSFLFQLCKGVSHCHAHGVLHRDLKPQNLLLDKDKGVLKIADLGLARAFTVPL 168 Query: 273 PPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKIC 452 YT + T YRAPEVLL +S Y+ ++DM ++G I AE+ LFPG++E QL I Sbjct: 169 KSYTHEIVTLSYRAPEVLLGSSHYSTAVDMSSVGCIFAEMVRRQALFPGDSEFQQLLHIF 228 Query: 453 AVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLI 596 +LGTP WP +L + Q P+N +P+ + LDL+ Sbjct: 229 RLLGTPSDEQWPGVSSL--RDWHVYPQWEPQNSAPAVPSLGPDGLDLL 274
>PFTK1_HUMAN (O94921) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 117 bits (293), Expect = 3e-26 Identities = 66/177 (37%), Positives = 100/177 (56%), Gaps = 3/177 (1%) Frame = +3 Query: 30 ITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENL 209 +T +++T C D + + ++ F+ Q+L+GL Y+H HRDLKP+NL Sbjct: 206 LTLVFEYVHTDLCQYMD---KHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNL 262 Query: 210 LVSN-GIVKIADFGLAR-EVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAIL 383 L+S+ G +K+ADFGLAR + + Y++ V T WYR P+VLL ++ Y+ +DMW +G I Sbjct: 263 LISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIF 322 Query: 384 AELFTLSPLFPGETE-TDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRNL 551 E+ FPG + DQL +I VLGTP+ WP +LP +F +NL Sbjct: 323 VEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNL 379
>MK14B_DROME (O61443) Mitogen-activated protein kinase 14B (EC 2.7.11.24) (MAP| kinase p38b) (D-p38b) Length = 365 Score = 117 bits (292), Expect = 3e-26 Identities = 68/173 (39%), Positives = 100/173 (57%), Gaps = 2/173 (1%) Frame = +3 Query: 93 RSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCS 269 R+ S++ ++ + QIL+GL Y+H+ G HRDLKP N+ V+ ++I DFGLAR S Sbjct: 121 RTQKLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAES 180 Query: 270 TPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKI 449 T YV+TRWYRAPE++L Y + D+W++G I+AEL T LFPG QL I Sbjct: 181 E--MTGYVATRWYRAPEIMLNWMHYNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLI 238 Query: 450 CAVLGTP-DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 VLGTP D + R+ +P RN ++ A+ A+DL++++ Sbjct: 239 MEVLGTPADEFMSRISSESARNYIRSLPVMPRRNFRDIFRGANPLAIDLLEKM 291
>CDK9_XENTR (Q6GLD8) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 376 Score = 117 bits (292), Expect = 3e-26 Identities = 73/190 (38%), Positives = 106/190 (55%), Gaps = 11/190 (5%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L ++ F+ EI+K M +L GL Y+H N HRD+K N+L++ +G++K+ADF Sbjct: 113 DLAGLLSNAHVKFTLSEIKKVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADF 172 Query: 246 GLAREVC----STP-PYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPL 410 GLAR S P YT+ V T WYR PE+LL Y P ID+W G I+AE++T SP+ Sbjct: 173 GLARAFSLAKNSQPNKYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPI 232 Query: 411 FPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIP---PRNLWELIPN--AS 575 G TE QL I + G+ +WP N+ + +Q ++P R + E + Sbjct: 233 MQGNTEQHQLTLISQLCGSITPEVWP---NVDKYELYQKLELPKGQKRKVKERLKAYVKD 289 Query: 576 LEALDLIKQL 605 L ALDLI +L Sbjct: 290 LYALDLIDKL 299
>CRK1_LEIME (Q06309) Cell division protein kinase 2 homolog CRK1 (EC 2.7.11.23)| Length = 301 Score = 117 bits (292), Expect = 3e-26 Identities = 56/135 (41%), Positives = 84/135 (62%), Gaps = 2/135 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVC-STPPYTDYV 293 I+ FM +L+G+ + H HRDLKP+NLL+S +K+ DFGL R +T+ V Sbjct: 104 IQHFMRDLLRGVAFCHQRSVLHRDLKPQNLLISREKELKLGDFGLGRSFAIPVRKFTNEV 163 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR P+VLL + Y P +D+W++G I +E+ T +PLF G+ + DQL +I LGTP+ Sbjct: 164 VTLWYRPPDVLLGSMQYGPPVDVWSVGCIFSEMATGTPLFAGKNDADQLMRIFRFLGTPN 223 Query: 474 HSLWPEGMNLPRSSS 518 + +WP P S++ Sbjct: 224 NRVWPSMNQYPNSNN 238
>MK14B_CYPCA (Q9I958) Mitogen-activated protein kinase 14b (EC 2.7.11.24)| (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (cp38b) Length = 361 Score = 117 bits (292), Expect = 3e-26 Identities = 68/172 (39%), Positives = 102/172 (59%), Gaps = 6/172 (3%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYT 284 +++ ++ + QIL+GL Y+H+ HRDLKP NL V+ +KI DFGLAR + T Sbjct: 124 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--LTDDEMT 181 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L Y ++D+W++G I+AEL T LFPG +QL +I + G Sbjct: 182 GYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 241 Query: 465 TPDHSLWP-----EGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TP SL E N S S+ +P RN ++ A+ A+DL++++ Sbjct: 242 TPPASLISRMPSHEARNYINSLSY----MPKRNFADVFVGANPMAVDLLEKM 289
>MK12_BRARE (O42376) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Stress-activated protein kinase 3) Length = 363 Score = 117 bits (292), Expect = 3e-26 Identities = 66/165 (40%), Positives = 98/165 (59%), Gaps = 2/165 (1%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYT 284 SEE ++ + Q+L+GL Y+H G HRDLKP NL ++ +KI DFGLAR+ S T Sbjct: 124 SEERVQYLVYQMLKGLKYIHAAGIIHRDLKPGNLAINEECELKILDFGLARQTDSE--MT 181 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV TRWYRAPEV+L YT ++D+W++G I+AE+ PLF G DQL +I V G Sbjct: 182 GYVVTRWYRAPEVILSWMHYTQTVDIWSVGCIMAEMLLGKPLFKGHDHLDQLMEIMKVTG 241 Query: 465 TPDHSLWPEGMNL-PRSSSFQFFQIPPRNLWELIPNASLEALDLI 596 TP + + R+ + + ++L L+PN + +A+ ++ Sbjct: 242 TPSKEFTAKLQSEDARNYVTKLPRFRKKDLRILLPNVNPQAIKVL 286
>GSK3H_DROME (P83101) Putative glycogen synthase kinase-3 homolog (EC 2.7.11.26)| (GSK-3) (Protein gasket) Length = 501 Score = 117 bits (292), Expect = 3e-26 Identities = 59/166 (35%), Positives = 104/166 (62%), Gaps = 4/166 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN--GIVKIADFGLAREVCSTPPYTDYV 293 +R +M Q+L+ + Y+H+ G+ HRD+KP+N+L+ + G++K+ DFG A+++ S P Y+ Sbjct: 135 VRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISGEPNVSYI 194 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 +R+YRAPE++ ++ YT IDMW+ G +++EL +FPG++ DQ+ +I V+GTP Sbjct: 195 CSRYYRAPELIFGSTDYTTKIDMWSAGCVMSELLLGQLIFPGDSGVDQIVEIVKVMGTPT 254 Query: 474 HSLWPEGMNLPRSSSFQFFQIPPRNLWELI--PNASLEALDLIKQL 605 S MN P F+ ++ P + W + EA+DL+ ++ Sbjct: 255 -SEQLHDMN-PHYKQFKLPELKP-HPWSKVFRIRTPAEAIDLVSKM 297
>FUS3_YEAST (P16892) Mitogen-activated protein kinase FUS3 (EC 2.7.11.24) (MAP| kinase FUS3) Length = 353 Score = 116 bits (291), Expect = 5e-26 Identities = 64/180 (35%), Positives = 102/180 (56%), Gaps = 14/180 (7%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKIADFGLAREVCSTPP-- 278 S++ I+ F+ Q L+ + +H + HRDLKP NLL+ SN +K+ DFGLAR + + Sbjct: 110 SDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADN 169 Query: 279 ---------YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETET 431 T+YV+TRWYRAPEV+L ++ Y+ ++D+W+ G ILAELF P+FPG Sbjct: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 Query: 432 DQLFKICAVLGTPDHSLWPEGMNLPRSSSF--QFFQIPPRNLWELIPNASLEALDLIKQL 605 QL I ++GTP + PR+ + P L ++ P + + +DL++++ Sbjct: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289
>HOG1_CANAL (Q92207) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 377 Score = 116 bits (291), Expect = 5e-26 Identities = 59/126 (46%), Positives = 81/126 (64%), Gaps = 1/126 (0%) Frame = +3 Query: 96 SAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCST 272 S P ++ I+ F QI++GL Y+H+ G HRDLKP N+L++ N +KI DFGLAR Sbjct: 113 SRPLEKQFIQYFTYQIMRGLKYIHSAGVIHRDLKPSNILINENCDLKICDFGLAR--LQD 170 Query: 273 PPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKIC 452 P T YVSTR+YRAPE++L Y +D+W++G ILAE+ PLFPG+ Q I Sbjct: 171 PQMTGYVSTRYYRAPEIMLTWQKYDTEVDLWSVGCILAEMIEGKPLFPGKDHVHQFSIIT 230 Query: 453 AVLGTP 470 +LG+P Sbjct: 231 ELLGSP 236
>HOG1_DEBHA (Q9UV50) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 387 Score = 116 bits (290), Expect = 6e-26 Identities = 59/126 (46%), Positives = 81/126 (64%), Gaps = 1/126 (0%) Frame = +3 Query: 96 SAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCST 272 S P ++ I+ F QIL+GL Y+H+ G HRDLKP N+L++ N +KI DFGLAR Sbjct: 113 SRPLEKQFIQYFTYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLAR--IQD 170 Query: 273 PPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKIC 452 P T YVSTR+YRAPE++L Y +D+W++G IL+E+ PLFPG+ Q I Sbjct: 171 PQMTGYVSTRYYRAPEIMLTWQKYDTEVDLWSVGCILSEMIEGKPLFPGKDHVHQFSIIT 230 Query: 453 AVLGTP 470 +LG+P Sbjct: 231 ELLGSP 236
>KSG9_ARATH (Q39012) Shaggy-related protein kinase iota (EC 2.7.11.1)| (ASK-iota) Length = 407 Score = 115 bits (288), Expect = 1e-25 Identities = 70/170 (41%), Positives = 99/170 (58%), Gaps = 5/170 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHN-NGYFHRDLKPENLLVS--NGIVKIADFGLAREVCSTPPYTDY 290 ++ + QI +GL Y+H G HRD+KP+NLLV VK+ DFG A+ + P Y Sbjct: 171 VKLYTYQIFRGLAYIHTVPGVCHRDVKPQNLLVDPLTHQVKLCDFGSAKVLVKGEPNISY 230 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ A+ YT SID+W+ G +LAEL PLFPGE DQL +I VLGTP Sbjct: 231 ICSRYYRAPELIFGATEYTASIDIWSAGCVLAELLLGQPLFPGENSVDQLVEIIKVLGTP 290 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASL--EALDLIKQLCSW 614 MN P + F+F QI + W + + + EA+DL +L + Sbjct: 291 TRE-EIRCMN-PNYTDFRFPQI-KAHPWHKVFHKRMPPEAIDLASRLLQY 337
>CDK9B_XENLA (Q7ZX42) Cell division protein kinase 9-B (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9-B) Length = 376 Score = 115 bits (288), Expect = 1e-25 Identities = 64/163 (39%), Positives = 94/163 (57%), Gaps = 6/163 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L ++ F+ EI+K M +L GL Y+H N HRD+K N+L++ +G++K+ADF Sbjct: 113 DLAGLLSNAHVKFTVAEIKKVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADF 172 Query: 246 GLAREVC----STP-PYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPL 410 GLAR S P YT+ V T WYR PE+LL Y P ID+W G I+AE++T SP+ Sbjct: 173 GLARAFSLAKNSQPNKYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPI 232 Query: 411 FPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIP 539 G TE QL I + G+ +WP N+ + +Q ++P Sbjct: 233 MQGNTEQHQLTLISQLCGSITPEVWP---NVDKYELYQKLELP 272
>CDK9A_XENLA (Q4V862) Cell division protein kinase 9-A (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9-A) Length = 376 Score = 115 bits (288), Expect = 1e-25 Identities = 64/163 (39%), Positives = 94/163 (57%), Gaps = 6/163 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L ++ F+ EI+K M +L GL Y+H N HRD+K N+L++ +G++K+ADF Sbjct: 113 DLAGLLSNAHVKFTLSEIKKVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADF 172 Query: 246 GLAREVC----STP-PYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPL 410 GLAR S P YT+ V T WYR PE+LL Y P ID+W G I+AE++T SP+ Sbjct: 173 GLARAFSLAKNSQPNKYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPI 232 Query: 411 FPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIP 539 G TE QL I + G+ +WP N+ + +Q ++P Sbjct: 233 MQGNTEQHQLTLISQLCGSITPEVWP---NVDKYELYQKLELP 272
>MK14_RAT (P70618) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1) Length = 359 Score = 115 bits (288), Expect = 1e-25 Identities = 65/168 (38%), Positives = 98/168 (58%), Gaps = 2/168 (1%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYT 284 +++ ++ + QIL+GL Y+H+ HRDLKP NL V+ +KI DFGLAR + T Sbjct: 122 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMT 179 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L Y ++D+W++G I+AEL T LFPG DQL I ++G Sbjct: 180 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 239 Query: 465 TPDHSLWPE-GMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TP L + R+ Q+P N + A+ A+DL++++ Sbjct: 240 TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKM 287
>MK14_MOUSE (P47811) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1) Length = 359 Score = 115 bits (288), Expect = 1e-25 Identities = 65/168 (38%), Positives = 98/168 (58%), Gaps = 2/168 (1%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYT 284 +++ ++ + QIL+GL Y+H+ HRDLKP NL V+ +KI DFGLAR + T Sbjct: 122 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMT 179 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L Y ++D+W++G I+AEL T LFPG DQL I ++G Sbjct: 180 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 239 Query: 465 TPDHSLWPE-GMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TP L + R+ Q+P N + A+ A+DL++++ Sbjct: 240 TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKM 287
>MK14_HUMAN (Q16539) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting prote Length = 359 Score = 115 bits (288), Expect = 1e-25 Identities = 65/168 (38%), Positives = 98/168 (58%), Gaps = 2/168 (1%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYT 284 +++ ++ + QIL+GL Y+H+ HRDLKP NL V+ +KI DFGLAR + T Sbjct: 122 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMT 179 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L Y ++D+W++G I+AEL T LFPG DQL I ++G Sbjct: 180 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 239 Query: 465 TPDHSLWPE-GMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TP L + R+ Q+P N + A+ A+DL++++ Sbjct: 240 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKM 287
>MK14_CANFA (O02812) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) Length = 359 Score = 115 bits (288), Expect = 1e-25 Identities = 65/168 (38%), Positives = 98/168 (58%), Gaps = 2/168 (1%) Frame = +3 Query: 108 SEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYT 284 +++ ++ + QIL+GL Y+H+ HRDLKP NL V+ +KI DFGLAR + T Sbjct: 122 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMT 179 Query: 285 DYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLG 464 YV+TRWYRAPE++L Y ++D+W++G I+AEL T LFPG DQL I ++G Sbjct: 180 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 239 Query: 465 TPDHSLWPE-GMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIKQL 605 TP L + R+ Q+P N + A+ A+DL++++ Sbjct: 240 TPGADLLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKM 287
>MK14A_DROME (O62618) Mitogen-activated protein kinase 14A (EC 2.7.11.24) (MAP| kinase p38a) (p38 MAPK) (Dp38) (D-p38a) Length = 366 Score = 115 bits (288), Expect = 1e-25 Identities = 67/175 (38%), Positives = 101/175 (57%), Gaps = 4/175 (2%) Frame = +3 Query: 93 RSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCS 269 R S++ ++ + QIL+GL Y+H+ G HRDLKP N+ V+ ++I DFGLAR + Sbjct: 122 RMQHLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARP--T 179 Query: 270 TPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKI 449 T YV+TRWYRAPE++L Y ++D+W++G I+AEL T LFPG QL I Sbjct: 180 ENEMTGYVATRWYRAPEIMLNWMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLI 239 Query: 450 CAVLGTPDHSLWPEGMNLPRSSSFQFFQIPP---RNLWELIPNASLEALDLIKQL 605 +LGTP + + S Q +PP R+ + NA+ A+DL++++ Sbjct: 240 MEMLGTPPAEFLKKISSESARSYIQ--SLPPMKGRSFKNVFKNANPLAIDLLEKM 292
>MK14C_DROME (P83100) Putative mitogen-activated protein kinase 14C (EC| 2.7.11.24) (MAP kinase p38c) Length = 356 Score = 115 bits (288), Expect = 1e-25 Identities = 68/174 (39%), Positives = 108/174 (62%), Gaps = 3/174 (1%) Frame = +3 Query: 93 RSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCS 269 RS S++EIR + QIL+GL Y+H+ G HRDLKP N+ V+ N V+I DFGL+R +C+ Sbjct: 115 RSKRMSDQEIRIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSR-MCA 173 Query: 270 TPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKI 449 TD+V T WY APE++ YT +ID+W++G ILAEL T LF GE Q+ + Sbjct: 174 DK-MTDHVGTMWYLAPEIIFLRGQYTKAIDVWSVGCILAELITDRVLFRGENYVSQIRCL 232 Query: 450 CAVLGTPDHSLWPEGMNLPRSSSF-QFFQIPPR-NLWELIPNASLEALDLIKQL 605 ++GTP + G+++ RS ++ + + + R + L ++A+DL++++ Sbjct: 233 INIMGTPTRE-FITGISMERSRNYLEGYPLRQRCDFHHLFMGYDVQAIDLMEKM 285
>MSK3_MEDSA (P51139) Glycogen synthase kinase-3 homolog MsK-3 (EC 2.7.11.1)| Length = 411 Score = 115 bits (288), Expect = 1e-25 Identities = 69/170 (40%), Positives = 103/170 (60%), Gaps = 5/170 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNN-GYFHRDLKPENLLVSNGI--VKIADFGLAREVCSTPPYTDY 290 ++ + QI + L Y+HN+ G HRD+KP+NLLV+ +KI DFG A+ + P Y Sbjct: 175 VKLYSYQICRALAYIHNSIGVCHRDIKPQNLLVNPHTHQLKICDFGSAKVLVKGEPNISY 234 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ A+ YT +ID+W+ G +L EL PLFPGE+ DQL +I VLGTP Sbjct: 235 ICSRYYRAPELIFGATEYTTAIDIWSAGCVLGELLLGQPLFPGESGVDQLVEIIKVLGTP 294 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASL--EALDLIKQLCSW 614 + MN P + F+F QI + W I + + EA+DL+ +L + Sbjct: 295 TRE-EIKCMN-PNYTEFKFPQI-KAHPWHKIFHKRMPPEAVDLVSRLLQY 341
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 115 bits (287), Expect = 1e-25 Identities = 71/193 (36%), Positives = 101/193 (52%), Gaps = 4/193 (2%) Frame = +3 Query: 21 DGKITSCSSFLNTWXCNLYDVIRERSAPFSEEE--IRKFMLQILQGLVYMHNNGYFHRDL 194 + K+T F++ D +R P E ++ F Q+LQG+ + H N HRDL Sbjct: 77 ENKLTLVFEFMDNDLKKFMDSRLDREMPRGLELSLVKYFQWQLLQGVAFCHENRILHRDL 136 Query: 195 KPENLLVSN-GIVKIADFGLAREV-CSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWA 368 KP+NLL++N G +K+ DFGLAR ++ V T WYRAP+VL+ + Y SID+W+ Sbjct: 137 KPQNLLINNKGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYCTSIDIWS 196 Query: 369 IGAILAELFTLSPLFPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPPRN 548 G ILAE+ LFPG + +QL I +GTP W LP+ + QIP Sbjct: 197 CGCILAEMIMGKALFPGTNDDEQLKLIFETMGTPTEQTWVGVSQLPKYNP----QIP--- 249 Query: 549 LWELIPNASLEAL 587 L PN ++ L Sbjct: 250 ---LYPNKDIKQL 259
>MPK7_ARATH (Q39027) Mitogen-activated protein kinase homolog 7 (EC 2.7.11.24)| (MAP kinase 7) (AtMPK7) Length = 368 Score = 115 bits (287), Expect = 1e-25 Identities = 71/185 (38%), Positives = 108/185 (58%), Gaps = 6/185 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L+ +I+ S S++ + F+ Q+L+GL Y+H+ HRDLKP NLLV+ N +KI DF Sbjct: 119 DLHQIIKS-SQSLSDDHCKYFLFQLLRGLKYLHSANILHRDLKPGNLLVNANCDLKICDF 177 Query: 246 GLAREVCSTPPY-TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGE 422 GLAR + T+YV TRWYRAPE+LL Y SID+W++G I AE+ P+FPG Sbjct: 178 GLARTSQGNEQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAEILGRKPIFPGT 237 Query: 423 TETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIPP----RNLWELIPNASLEALD 590 +QL I V+G+ S + + + +F + P +L L P A+ A+D Sbjct: 238 ECLNQLKLIINVVGSQQES---DIRFIDNPKARRFIKSLPYSRGTHLSNLYPQANPLAID 294 Query: 591 LIKQL 605 L++++ Sbjct: 295 LLQRM 299
>KKQ1_YEAST (P36005) Probable serine/threonine-protein kinase YKL161C (EC| 2.7.11.1) Length = 433 Score = 114 bits (286), Expect = 2e-25 Identities = 67/187 (35%), Positives = 103/187 (55%), Gaps = 7/187 (3%) Frame = +3 Query: 66 CNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIAD 242 C+L +IR + + F+ QIL L Y+H+ H DLKP+NLLV++ +KI + Sbjct: 113 CDLSQIIRSEQR-LEDAHFQSFIYQILCALKYIHSANVLHCDLKPKNLLVNSDCQLKICN 171 Query: 243 FGLAREVCSTPPYTD-----YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSP 407 FGL+ D Y+++ WY+APE+LL T ++D+W+ G ILAEL P Sbjct: 172 FGLSCSYSENHKVNDGFIKGYITSIWYKAPEILLNYQECTKAVDIWSTGCILAELLGRKP 231 Query: 408 LFPGETETDQLFKICAVLGT-PDHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEA 584 +F G+ D L I +LGT P+ +L + FQF IP R+ ++P A+ EA Sbjct: 232 MFEGKDYVDHLNHILQILGTPPEETLQEIASQKVYNYIFQFGNIPGRSFESILPGANPEA 291 Query: 585 LDLIKQL 605 L+L+K++ Sbjct: 292 LELLKKM 298
>PFTK1_MOUSE (O35495) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 114 bits (286), Expect = 2e-25 Identities = 60/141 (42%), Positives = 88/141 (62%), Gaps = 3/141 (2%) Frame = +3 Query: 114 EEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSN-GIVKIADFGLAR-EVCSTPPYTD 287 + ++ F+ Q+L+GL Y+H HRDLKP+NLL+S+ G +K+ADFGLAR + + Y++ Sbjct: 231 DNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSN 290 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETE-TDQLFKICAVLG 464 V T WYR P+VLL ++ Y+ +DMW +G I E+ FPG + DQL +I VLG Sbjct: 291 EVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLG 350 Query: 465 TPDHSLWPEGMNLPRSSSFQF 527 TP+ WP +LP +F Sbjct: 351 TPNEDTWPGVHSLPHFKPERF 371
>CDKL1_HUMAN (Q00532) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIALRE) (Protein kinase p42 KKIALRE) Length = 357 Score = 114 bits (286), Expect = 2e-25 Identities = 65/180 (36%), Positives = 102/180 (56%), Gaps = 10/180 (5%) Frame = +3 Query: 90 ERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVC 266 +R P E ++ Q LQ + + H + HRD+KPEN+L++ + ++K+ DFG AR + Sbjct: 95 QRGVP--EHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT 152 Query: 267 STPPY-TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLF 443 Y TDYV+TRWYR+PE+L+ + Y P +D+WAIG + AEL + PL+PG+++ DQL+ Sbjct: 153 GPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLY 212 Query: 444 KICAVLG--TPDH------SLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIK 599 I LG P H + + G+ +P + ++ PN S AL L+K Sbjct: 213 LIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELK-------FPNISYPALGLLK 265
>MSK1_TOBAC (Q40518) Shaggy-related protein kinase NtK-1 (EC 2.7.11.1)| Length = 409 Score = 114 bits (286), Expect = 2e-25 Identities = 69/170 (40%), Positives = 103/170 (60%), Gaps = 5/170 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNN-GYFHRDLKPENLLVSNGI--VKIADFGLAREVCSTPPYTDY 290 ++ + QI + L Y+H+ G HRD+KP+NLLV+ VK+ DFG A+ + P Y Sbjct: 174 VKLYTYQIFRALSYIHHTIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISY 233 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ A+ YT +ID+W+ G +LAEL PLFPGE+ DQL +I VLGTP Sbjct: 234 ICSRYYRAPELIFGATEYTTAIDIWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTP 293 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASL--EALDLIKQLCSW 614 + MN P + F+F QI + W I + + EA+DL+ +L + Sbjct: 294 TRE-EIKCMN-PNYNEFKFPQI-KAHPWHKIFHKRMPPEAVDLVSRLLQY 340
>KSG6_ARATH (Q39010) Shaggy-related protein kinase dzeta (EC 2.7.11.1)| (ASK-dzeta) Length = 412 Score = 114 bits (284), Expect = 3e-25 Identities = 69/170 (40%), Positives = 98/170 (57%), Gaps = 5/170 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNN-GYFHRDLKPENLLVSNGI--VKIADFGLAREVCSTPPYTDY 290 ++ + QI +GL Y+H G HRD+KP+NLLV K+ DFG A+ + P Y Sbjct: 173 VKLYTYQIFRGLAYIHTAPGVCHRDIKPQNLLVDPHTHQCKLCDFGSAKVLVKGEPNISY 232 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ A+ YT SID+W+ G +LAEL PLFPGE DQL +I VLGTP Sbjct: 233 ICSRYYRAPELIFGATEYTSSIDIWSAGCVLAELLLGQPLFPGENSVDQLVEIIKVLGTP 292 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASL--EALDLIKQLCSW 614 MN P + F+F QI + W + + + EA+DL +L + Sbjct: 293 TRE-EIRCMN-PNYTDFRFPQI-KAHPWHKVFHKRMPPEAIDLASRLLQY 339
>CC2H1_TRYBB (P38973) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 114 bits (284), Expect = 3e-25 Identities = 57/135 (42%), Positives = 82/135 (60%), Gaps = 2/135 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREV-CSTPPYTDYV 293 I++FM +L G+ + H HRDLKP NLL+S +K+ADFGL R +T V Sbjct: 104 IQEFMRSLLSGVRFCHERNVLHRDLKPPNLLISREKELKLADFGLGRAFGIPVKKFTQEV 163 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR+P+VLL ++ Y +D+W++G I AE+ +PLF G+ + DQL +I LGTP+ Sbjct: 164 VTLWYRSPDVLLGSTQYGTPVDIWSVGCIFAEMAIGAPLFTGKNDADQLLRIFQFLGTPN 223 Query: 474 HSLWPEGMNLPRSSS 518 +WP P SS+ Sbjct: 224 RQVWPSMDTYPNSSN 238
>KSG5_ARATH (Q8VZD5) Shaggy-related protein kinase epsilon (EC 2.7.11.1)| (ASK-epsilon) Length = 410 Score = 114 bits (284), Expect = 3e-25 Identities = 69/170 (40%), Positives = 100/170 (58%), Gaps = 5/170 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNN-GYFHRDLKPENLLVSNGI--VKIADFGLAREVCSTPPYTDY 290 ++ + QI + L Y+H G HRD+KP+NLLV+ VK+ DFG A+ + P Y Sbjct: 175 VKLYTYQICRALAYIHGGVGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISY 234 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ A+ YT +ID+W+ G +LAEL PLFPGE+ DQL +I VLGTP Sbjct: 235 ICSRYYRAPELIFGATEYTTTIDIWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTP 294 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELI--PNASLEALDLIKQLCSW 614 + MN P + F+F QI + W I EA+DL+ +L + Sbjct: 295 TRE-EIKCMN-PNYTEFKFPQI-KAHPWHKIFHKRTPPEAVDLVSRLLQY 341
>MK11_HUMAN (Q15759) Mitogen-activated protein kinase 11 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress-activated protein kinase 2) Length = 372 Score = 114 bits (284), Expect = 3e-25 Identities = 62/167 (37%), Positives = 100/167 (59%), Gaps = 2/167 (1%) Frame = +3 Query: 111 EEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYTD 287 +E ++ + Q+L+GL Y+H+ G HRDLKP N+ V+ ++I DFGLAR+ + T Sbjct: 132 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQ--ADEEMTG 189 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGT 467 YV+TRWYRAPE++L Y ++D+W++G I+AEL LFPG DQL +I V+GT Sbjct: 190 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 249 Query: 468 PDHSLWPEGMNLPRSSSFQFF-QIPPRNLWELIPNASLEALDLIKQL 605 P + + + + Q +P ++L + A+ A+DL+ ++ Sbjct: 250 PSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRM 296
>CDK9_CHICK (Q5ZKN1) Cell division protein kinase 9 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent kinase 9) Length = 372 Score = 114 bits (284), Expect = 3e-25 Identities = 64/163 (39%), Positives = 94/163 (57%), Gaps = 6/163 (3%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L ++ F+ EI+K M +L GL Y+H N HRD+K N+L++ +G++K+ADF Sbjct: 109 DLAGLLSNTHVKFTLSEIKKVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADF 168 Query: 246 GLAREVC----STPP-YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPL 410 GLAR S P YT+ V T WYR PE+LL Y P ID+W G I+AE++T SP+ Sbjct: 169 GLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGGGCIMAEMWTRSPI 228 Query: 411 FPGETETDQLFKICAVLGTPDHSLWPEGMNLPRSSSFQFFQIP 539 G TE QL I + G+ +WP N+ + +Q ++P Sbjct: 229 MQGNTEQHQLTLISQLCGSITPEVWP---NVDKYELYQKLELP 268
>MSK1_MEDSA (P51137) Glycogen synthase kinase-3 homolog MsK-1 (EC 2.7.11.1)| Length = 411 Score = 114 bits (284), Expect = 3e-25 Identities = 69/170 (40%), Positives = 102/170 (60%), Gaps = 5/170 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNN-GYFHRDLKPENLLVSNGI--VKIADFGLAREVCSTPPYTDY 290 ++ + QI + L Y+H G HRD+KP+NLLV+ VK+ DFG A+ + P Y Sbjct: 176 VKLYTYQIFRALSYIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISY 235 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ A+ YT +ID+W++G +LAEL PLFPGE DQL +I VLGTP Sbjct: 236 ICSRYYRAPELIFGATEYTTAIDVWSVGCVLAELLLGQPLFPGERGVDQLVEIIKVLGTP 295 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASL--EALDLIKQLCSW 614 + MN P + F+F QI + W I + + EA+DL+ +L + Sbjct: 296 TRE-EIKCMN-PNYTEFKFPQI-KAHPWHKIFHKRMPAEAVDLVSRLLQY 342
>CDKL1_RAT (Q66HE7) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 113 bits (283), Expect = 4e-25 Identities = 64/180 (35%), Positives = 101/180 (56%), Gaps = 10/180 (5%) Frame = +3 Query: 90 ERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVC 266 +R P E ++ Q LQ + + H + HRD+KPEN+L++ + ++K+ DFG AR + Sbjct: 95 QRGVP--EPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT 152 Query: 267 STPPY-TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLF 443 Y TDYV+TRWYR+PE+L+ + Y P +D+WAIG + AEL + PL+PG+++ DQL+ Sbjct: 153 GPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLY 212 Query: 444 KICAVLG--TPDH------SLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASLEALDLIK 599 I LG P H + + G+ +P + ++ PN S AL +K Sbjct: 213 LIRKTLGDLIPRHQQVFSMNQYFSGVKIPDPEDMETLELK-------FPNISYSALGFLK 265
>MDS1_YEAST (P38615) Serine/threonine-protein kinase MDS1/RIM11 (EC 2.7.11.1)| Length = 370 Score = 113 bits (283), Expect = 4e-25 Identities = 58/140 (41%), Positives = 88/140 (62%), Gaps = 6/140 (4%) Frame = +3 Query: 69 NLYDVIRE---RSAPFSEEEIRKFMLQILQGLVYMHN-NGYFHRDLKPENLLVS--NGIV 230 +LY +R + P S EI+ +M Q+ + L Y+H+ HRD+KP+NLLV + Sbjct: 120 SLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSLNYLHHFANVCHRDIKPQNLLVDPETWSL 179 Query: 231 KIADFGLAREVCSTPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPL 410 K+ DFG A+++ T P Y+ +R+YRAPE++ A+ YT ID+W+ G ++AEL P+ Sbjct: 180 KLCDFGSAKQLKPTEPNVSYICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPM 239 Query: 411 FPGETETDQLFKICAVLGTP 470 FPGE+ DQL +I +LGTP Sbjct: 240 FPGESGIDQLVEIIKILGTP 259
>MK15_HUMAN (Q8TD08) Mitogen-activated protein kinase 15 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 8) Length = 544 Score = 113 bits (283), Expect = 4e-25 Identities = 76/205 (37%), Positives = 109/205 (53%), Gaps = 9/205 (4%) Frame = +3 Query: 18 DDGKITSCSSFLNTWXCNLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLK 197 +D I F++T +L VIR + + +R Q+L+ ++H+ HRD K Sbjct: 84 NDRDIYLVFEFMDT---DLNAVIR-KGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQK 139 Query: 198 PENLLV-SNGIVKIADFGLAREVCSTPP------YTDYVSTRWYRAPEVLLQASAYTPSI 356 P N+L+ +N VK+ DFGLAR + P T+YV+TRWYRAPEVLL + YT + Sbjct: 140 PSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGV 199 Query: 357 DMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP-DHSLWPEGMNLPRSSSFQFFQ 533 DMW++G IL E+ PLFPG + QL I + P + L G S Q Sbjct: 200 DMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGS 259 Query: 534 IPPRNLWELI-PNASLEALDLIKQL 605 P + L L+ P+ S EALDL+++L Sbjct: 260 RPRQTLDALLPPDTSPEALDLLRRL 284
>CDKL1_BRARE (Q6AXJ9) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 350 Score = 113 bits (283), Expect = 4e-25 Identities = 69/174 (39%), Positives = 105/174 (60%), Gaps = 11/174 (6%) Frame = +3 Query: 111 EEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCSTPP--- 278 E ++ + Q LQ + + H HRD+KPEN+L++ + ++K+ DFG AR + T P Sbjct: 100 EHMVKSIIWQTLQAVNFCHKQNCIHRDVKPENILITKHQVIKLCDFGFARIL--TGPCDY 157 Query: 279 YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAV 458 YTD V+TRWYRAPE+L+ + Y P +D+WA+G + AEL + +PL+PG+++ DQL+ I Sbjct: 158 YTDCVATRWYRAPELLVGDTQYGPPVDVWAVGCVFAELLSGAPLWPGKSDVDQLYLIRKT 217 Query: 459 LGTPDHSLWPEGMNLPRSSSFQFFQ---IP-PRNLWEL---IPNASLEALDLIK 599 LG L P + S+ QFF +P P+ + L PN S +AL L+K Sbjct: 218 LG----ELIPRHQQV--FSTNQFFSGVCVPEPQEMEPLELKYPNLSYQALSLMK 265
>KSG1_ARATH (P43288) Shaggy-related protein kinase alpha (EC 2.7.11.1)| (ASK-alpha) Length = 405 Score = 113 bits (282), Expect = 5e-25 Identities = 69/170 (40%), Positives = 102/170 (60%), Gaps = 5/170 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNN-GYFHRDLKPENLLVSNGI--VKIADFGLAREVCSTPPYTDY 290 ++ + QI + L Y+H G HRD+KP+NLLV+ VK+ DFG A+ + P Y Sbjct: 170 VKLYTYQIFRALSYIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISY 229 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ A+ YT +ID+W+ G +LAEL PLFPGE+ DQL +I VLGTP Sbjct: 230 ICSRYYRAPELIFGATEYTTAIDVWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTP 289 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASL--EALDLIKQLCSW 614 + MN P + F+F QI + W I + + EA+DL+ +L + Sbjct: 290 TRE-EIKCMN-PNYTEFKFPQI-KAHPWHKIFHKRMPPEAVDLVSRLLQY 336
>MPK2_ARATH (Q39022) Mitogen-activated protein kinase homolog 2 (EC 2.7.11.24)| (MAP kinase 2) (AtMPK2) Length = 376 Score = 113 bits (282), Expect = 5e-25 Identities = 71/184 (38%), Positives = 110/184 (59%), Gaps = 5/184 (2%) Frame = +3 Query: 69 NLYDVIRERSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADF 245 +L+ +I+ S S + + F+ Q+L+GL Y+H+ HRDLKP NLLV+ N +KI DF Sbjct: 119 DLHQIIKS-SQVLSNDHCQYFLFQLLRGLKYIHSANILHRDLKPGNLLVNANCDLKICDF 177 Query: 246 GLAREVCSTPPY-TDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGE 422 GLAR + + T+YV TRWYRAPE+LL Y SID+W++G I AEL P+FPG Sbjct: 178 GLARTSNTKGQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAELLGRKPVFPGT 237 Query: 423 TETDQLFKICAVLGTP-DHSLWPEGMNLPRSSSF--QFFQIPPRNLWELIPNASLEALDL 593 +Q+ I +LG+ + L E ++ P++ + P + L P A++ A+DL Sbjct: 238 ECLNQIKLIINILGSQREEDL--EFIDNPKAKRYIESLPYSPGISFSRLYPGANVLAIDL 295 Query: 594 IKQL 605 ++++ Sbjct: 296 LQKM 299
>HOG1_ASHGO (Q750A9) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 113 bits (282), Expect = 5e-25 Identities = 57/127 (44%), Positives = 81/127 (63%), Gaps = 1/127 (0%) Frame = +3 Query: 93 RSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCS 269 ++ P ++ ++ F+ QIL+GL Y+H+ G HRDLKP N+L++ N +KI DFGLAR Sbjct: 112 QTRPLEKQFLQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLAR--IQ 169 Query: 270 TPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKI 449 P T YVSTR+YRAPE++L Y +D+W+ G I AE+ PLFPG+ Q I Sbjct: 170 DPQMTGYVSTRYYRAPEIMLTWQKYNVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSII 229 Query: 450 CAVLGTP 470 +LG+P Sbjct: 230 TDLLGSP 236
>KSS1_YEAST (P14681) Mitogen-activated protein kinase KSS1 (EC 2.7.11.24) (MAP| kinase KSS1) (Kinase suppressor of SST2) Length = 368 Score = 113 bits (282), Expect = 5e-25 Identities = 63/146 (43%), Positives = 91/146 (62%), Gaps = 12/146 (8%) Frame = +3 Query: 69 NLYDVIRERSAPFS---EEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLV-SNGIVKI 236 +L VI +++ FS ++ ++ F QIL+ L +H+ HRD+KP NLL+ SN +K+ Sbjct: 100 DLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLLNSNCDLKV 159 Query: 237 ADFGLAREVCSTPP--------YTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAEL 392 DFGLAR + S+ T+YV+TRWYRAPE++L YT ++D+W+ G ILAE+ Sbjct: 160 CDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEM 219 Query: 393 FTLSPLFPGETETDQLFKICAVLGTP 470 + PLFPG QL+ I VLGTP Sbjct: 220 VSGKPLFPGRDYHHQLWLILEVLGTP 245
>KSG3_ARATH (P43289) Shaggy-related protein kinase gamma (EC 2.7.11.1)| (ASK-gamma) Length = 409 Score = 113 bits (282), Expect = 5e-25 Identities = 69/170 (40%), Positives = 102/170 (60%), Gaps = 5/170 (2%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNN-GYFHRDLKPENLLVSNGI--VKIADFGLAREVCSTPPYTDY 290 ++ + QI + L Y+H G HRD+KP+NLLV+ VK+ DFG A+ + P Y Sbjct: 174 VKLYTYQIFRSLSYIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNISY 233 Query: 291 VSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTP 470 + +R+YRAPE++ A+ YT +ID+W+ G +LAEL PLFPGE+ DQL +I VLGTP Sbjct: 234 ICSRYYRAPELIFGATEYTTAIDVWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTP 293 Query: 471 DHSLWPEGMNLPRSSSFQFFQIPPRNLWELIPNASL--EALDLIKQLCSW 614 + MN P + F+F QI + W I + + EA+DL+ +L + Sbjct: 294 TRE-EIKCMN-PNYTEFKFPQI-KAHPWHKIFHKRMPPEAVDLVSRLLQY 340
>HOG1_YEAST (P32485) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) (Osmosensing protein HOG1) Length = 435 Score = 113 bits (282), Expect = 5e-25 Identities = 57/127 (44%), Positives = 81/127 (63%), Gaps = 1/127 (0%) Frame = +3 Query: 93 RSAPFSEEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVS-NGIVKIADFGLAREVCS 269 ++ P ++ ++ F+ QIL+GL Y+H+ G HRDLKP N+L++ N +KI DFGLAR Sbjct: 112 QTRPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLAR--IQ 169 Query: 270 TPPYTDYVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKI 449 P T YVSTR+YRAPE++L Y +D+W+ G I AE+ PLFPG+ Q I Sbjct: 170 DPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSII 229 Query: 450 CAVLGTP 470 +LG+P Sbjct: 230 TDLLGSP 236
>CC2H1_TRYCO (P54664) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 112 bits (281), Expect = 7e-25 Identities = 59/135 (43%), Positives = 84/135 (62%), Gaps = 2/135 (1%) Frame = +3 Query: 120 IRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREV-CSTPPYTDYV 293 I++FM +L+G+ + H HRDLKP NLL+S +K+ADFGL R YT V Sbjct: 104 IQEFMRSLLKGVRFCHERNVLHRDLKPPNLLISREKELKLADFGLGRAFGIPVKKYTHEV 163 Query: 294 STRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGTPD 473 T WYR+P+VLL ++ Y +D+W++G I AE+ +PLF G+ + DQL +I LGTP Sbjct: 164 VTLWYRSPDVLLGSTQYGTPVDIWSVGCIFAEMAIGAPLFAGKNDADQLLRIFRFLGTPS 223 Query: 474 HSLWPEGMNLPRSSS 518 +WP MNL +S+ Sbjct: 224 SQVWP-SMNLYPNST 237
>MK12_HUMAN (P53778) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 112 bits (281), Expect = 7e-25 Identities = 60/121 (49%), Positives = 78/121 (64%), Gaps = 1/121 (0%) Frame = +3 Query: 111 EEEIRKFMLQILQGLVYMHNNGYFHRDLKPENLLVSNGI-VKIADFGLAREVCSTPPYTD 287 E+ I+ + Q+L+GL Y+H G HRDLKP NL V+ +KI DFGLAR+ S T Sbjct: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTG 184 Query: 288 YVSTRWYRAPEVLLQASAYTPSIDMWAIGAILAELFTLSPLFPGETETDQLFKICAVLGT 467 YV TRWYRAPEV+L YT ++D+W++G I+AE+ T LF G DQL +I V GT Sbjct: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 Query: 468 P 470 P Sbjct: 245 P 245 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 92,181,094 Number of Sequences: 219361 Number of extensions: 2026899 Number of successful extensions: 9121 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6937 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7215 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5538924943 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
