>PSL2_MOUSE (Q9JJF9) Signal peptide peptidase-like 2A (EC 3.4.23.-) (SPP-like|
           2A protein) (SPPL2a protein) (Intramembrane protease 3)
           (IMP3) (Presenilin-like protein 2)
          Length = 523

 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 47/114 (41%), Positives = 69/114 (60%)
 Frame = +3

Query: 24  SIIGFGDILLPGLVVAFALRYDWAAKKSMRSGYFLWSASAYGTGLLITYVALNLMDGHGQ 203
           S++GFGDI++PGL++A+  R+D     S+   Y++ S  AY  G++IT+V L +M   GQ
Sbjct: 410 SVLGFGDIIVPGLLIAYCRRFDVQTGSSI---YYISSTIAYAVGMIITFVVLMVMKT-GQ 465

Query: 204 PALLYIVPFTLGTLISLGWKRGELRNLWLKGEPDRVCTHQGYVQMAKPPPADDE 365
           PALLY+VP TL T+  + W R E++  W KG   +V  H  Y    + P   DE
Sbjct: 466 PALLYLVPCTLITVSVVAWSRKEMKKFW-KGSSYQVMGHLDYSTNEENPVTTDE 518

>PSL1_CHICK (Q5F383) Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein|
           SPP-like 2B) (Protein SPPL2b)
          Length = 596

 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 55/131 (41%), Positives = 72/131 (54%), Gaps = 9/131 (6%)
 Frame = +3

Query: 21  YSIIGFGDILLPGLVVAFALRYDWAAKKSMRSGYFLWSASAYGTGLLITYVALNLMDGHG 200
           +S++GFGDIL+PGL+VA+  R+D   + S    YF+    AYG GLL+T+VAL LM   G
Sbjct: 410 FSLLGFGDILVPGLLVAYCHRFDIQVQSS--RVYFVACTIAYGIGLLVTFVALALMQ-MG 466

Query: 201 QPALLYIVPFTLGTLISLGWKRGELRNLWLKG-------EPDRVCTHQGYVQMAKPP--P 353
           QPALLY+VP TL T  S+   R EL   W          +P  V       Q+ K    P
Sbjct: 467 QPALLYLVPCTLITSFSVALWRKELAMFWTGSGFAKDLPQPPLVIASVNCPQLPKDSNVP 526

Query: 354 ADDEDGEEAKN 386
           A  ++ EE  N
Sbjct: 527 ASQQETEEMAN 537

>PSL1_HUMAN (Q8TCT7) Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein|
           SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4)
           (IMP4) (Presenilin-like protein 1)
          Length = 592

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 49/111 (44%), Positives = 66/111 (59%)
 Frame = +3

Query: 21  YSIIGFGDILLPGLVVAFALRYDWAAKKSMRSGYFLWSASAYGTGLLITYVALNLMDGHG 200
           +S++GFGDIL+PGL+VA+  R+D   + S    YF+    AYG GLL+T+VAL LM   G
Sbjct: 414 FSLLGFGDILVPGLLVAYCHRFDIQVQSS--RVYFVACTIAYGVGLLVTFVALALMQ-RG 470

Query: 201 QPALLYIVPFTLGTLISLGWKRGELRNLWLKGEPDRVCTHQGYVQMAKPPP 353
           QPALLY+VP TL T  ++   R EL   W         T  G+ ++  P P
Sbjct: 471 QPALLYLVPCTLVTSCAVALWRRELGVFW---------TGSGFAKVLPPSP 512

>PSL1_RAT (Q5PQL3) Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein|
           SPP-like 2B) (Protein SPPL2b)
          Length = 577

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 45/89 (50%), Positives = 60/89 (67%)
 Frame = +3

Query: 21  YSIIGFGDILLPGLVVAFALRYDWAAKKSMRSGYFLWSASAYGTGLLITYVALNLMDGHG 200
           +S++GFGDIL+PGL+VA+  R+D   + S    YF+    AYG GLL+T+VAL LM  HG
Sbjct: 407 FSLLGFGDILVPGLLVAYCHRFDIQVQSSRI--YFVACTIAYGLGLLVTFVALVLM-RHG 463

Query: 201 QPALLYIVPFTLGTLISLGWKRGELRNLW 287
           QPALLY+VP TL T  ++   R E+   W
Sbjct: 464 QPALLYLVPCTLLTSCTVALWRREMGAFW 492

>PSL2_HUMAN (Q8TCT8) Signal peptide peptidase-like 2A (EC 3.4.23.-) (Protein|
           SPP-like 2A) (Protein SPPL2a) (Intramembrane protease 3)
           (IMP3) (Presenilin-like protein 2)
          Length = 520

 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 43/99 (43%), Positives = 63/99 (63%)
 Frame = +3

Query: 24  SIIGFGDILLPGLVVAFALRYDWAAKKSMRSGYFLWSASAYGTGLLITYVALNLMDGHGQ 203
           SI+GFGDI++PGL++A+  R+D     S    Y++ S  AY  G+++T+V L LM   GQ
Sbjct: 406 SILGFGDIIVPGLLIAYCRRFDVQTGSSYI--YYVSSTVAYAIGMILTFVVLVLMK-KGQ 462

Query: 204 PALLYIVPFTLGTLISLGWKRGELRNLWLKGEPDRVCTH 320
           PALLY+VP TL T   + W+R E++  W KG   ++  H
Sbjct: 463 PALLYLVPCTLITASVVAWRRKEMKKFW-KGNSYQMMDH 500

>PSL1_MOUSE (Q3TD49) Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein|
           SPP-like 2B) (Protein SPPL2b)
          Length = 578

 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 45/89 (50%), Positives = 59/89 (66%)
 Frame = +3

Query: 21  YSIIGFGDILLPGLVVAFALRYDWAAKKSMRSGYFLWSASAYGTGLLITYVALNLMDGHG 200
           +S++GFGDIL+PGL+VA+  R+D   + S    YF+    AYG GLL+T+VAL LM   G
Sbjct: 407 FSLLGFGDILVPGLLVAYCHRFDIQVQSSRI--YFVACTIAYGLGLLVTFVALVLMQ-RG 463

Query: 201 QPALLYIVPFTLGTLISLGWKRGELRNLW 287
           QPALLY+VP TL T  ++   R EL   W
Sbjct: 464 QPALLYLVPCTLLTSCTVALWRRELGAFW 492

>PSL4_HUMAN (Q8TCT6) Signal peptide peptidase-like 3 (EC 3.4.23.-) (SPP-like 3|
           protein) (Intramembrane protease 2) (IMP2)
           (Presenilin-like protein 4)
          Length = 385

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 38/106 (35%), Positives = 58/106 (54%), Gaps = 17/106 (16%)
 Frame = +3

Query: 21  YSIIGFGDILLPGLVVAFALRYDWAAKKS-----------------MRSGYFLWSASAYG 149
           +S++G GDI++PGL++ F LRYD   K++                  +  YF  +   Y 
Sbjct: 265 FSMLGIGDIVMPGLLLCFVLRYDNYKKQASGDSCGAPGPANISGRMQKVSYFHCTLIGYF 324

Query: 150 TGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLW 287
            GLL   VA  +     QPALLY+VPFTL  L+++ + +G+LR +W
Sbjct: 325 VGLLTATVASRIHRA-AQPALLYLVPFTLLPLLTMAYLKGDLRRMW 369

>PSL4_MOUSE (Q9CUS9) Signal peptide peptidase-like 3 (EC 3.4.23.-) (SPP-like 3|
           protein) (Intramembrane protease 2) (IMP2)
           (Presenilin-like protein 4)
          Length = 384

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 38/106 (35%), Positives = 58/106 (54%), Gaps = 17/106 (16%)
 Frame = +3

Query: 21  YSIIGFGDILLPGLVVAFALRYDWAAKKS-----------------MRSGYFLWSASAYG 149
           +S++G GDI++PGL++ F LRYD   K++                  +  YF  +   Y 
Sbjct: 264 FSMLGIGDIVMPGLLLCFVLRYDNYKKQASGDSCGAPGPANISGRMQKVSYFHCTLIGYF 323

Query: 150 TGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLW 287
            GLL   VA  +     QPALLY+VPFTL  L+++ + +G+LR +W
Sbjct: 324 VGLLTATVASRIHRA-AQPALLYLVPFTLLPLLTMAYLKGDLRRMW 368

>HM13_MOUSE (Q9D8V0) Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal|
           peptide peptidase) (Presenilin-like protein 3)
          Length = 378

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 39/120 (32%), Positives = 67/120 (55%)
 Frame = +3

Query: 21  YSIIGFGDILLPGLVVAFALRYDWAAKKSMRSGYFLWSASAYGTGLLITYVALNLMDGHG 200
           ++++G GDI++PG+ +A  LR+D + KK+  + YF  S +AY  GL +T   +++   H 
Sbjct: 258 FAMLGLGDIVIPGIFIALLLRFDISLKKNTHT-YFYTSFAAYIFGLGLTIFIMHIFK-HA 315

Query: 201 QPALLYIVPFTLGTLISLGWKRGELRNLWLKGEPDRVCTHQGYVQMAKPPPADDEDGEEA 380
           QPALLY+VP  +G  + +   +GE+  ++   E +            K P A+ E  EE+
Sbjct: 316 QPALLYLVPACIGFPVLVALAKGEVAEMFSYEESN-----------PKDPAAETESKEES 364

>HM13_HUMAN (Q8TCT9) Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal|
           peptide peptidase) (Presenilin-like protein 3) (hIMP1
           protein)
          Length = 377

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 31/89 (34%), Positives = 57/89 (64%)
 Frame = +3

Query: 21  YSIIGFGDILLPGLVVAFALRYDWAAKKSMRSGYFLWSASAYGTGLLITYVALNLMDGHG 200
           ++++G GD+++PG+ +A  LR+D + KK+  + YF  S +AY  GL +T   +++   H 
Sbjct: 258 FAMLGLGDVVIPGIFIALLLRFDISLKKNTHT-YFYTSFAAYIFGLGLTIFIMHIFK-HA 315

Query: 201 QPALLYIVPFTLGTLISLGWKRGELRNLW 287
           QPALLY+VP  +G  + +   +GE+  ++
Sbjct: 316 QPALLYLVPACIGFPVLVALAKGEVTEMF 344

>YJ95_CAEEL (P49049) Hypothetical protein T05E11.5 in chromosome IV|
          Length = 468

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 34/100 (34%), Positives = 51/100 (51%), Gaps = 11/100 (11%)
 Frame = +3

Query: 21  YSIIGFGDILLPGLVVAFALRYDWAAKKSMRSG-----------YFLWSASAYGTGLLIT 167
           +S++G GDI++PG+ +A   R+D+   ++               YF+ +  AY  GL IT
Sbjct: 346 HSMLGLGDIVIPGIFIALLRRFDYRVVQTTAESKAPQGSLKGRYYFVVTVVAYMAGLFIT 405

Query: 168 YVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLW 287
              ++      QPALLY+VP  L   + L   RGEL  LW
Sbjct: 406 MAVMHHFKA-AQPALLYLVPCCLFVPLLLAVIRGELSALW 444

>YKK0_YEAST (P34248) Hypothetical 67.5 kDa protein in APE1/LAP4-CWP1 intergenic|
           region
          Length = 587

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 13/102 (12%)
 Frame = +3

Query: 21  YSIIGFGDILLPGLVVAFALRYD-WA------------AKKSMRSGYFLWSASAYGTGLL 161
           +SI+G GDI LPG+ +A   +YD W                S    YF+ +  +Y   L+
Sbjct: 404 FSILGLGDIALPGMFIAMCYKYDIWKWHLDHDDTEFHFLNWSYVGKYFITAMVSYVASLV 463

Query: 162 ITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLW 287
              V+L++ +   QPALLYIVP  L + I +     + +  W
Sbjct: 464 SAMVSLSIFN-TAQPALLYIVPSLLISTILVACWNKDFKQFW 504

>PSBZ_CRYJA (Q5IHA3) Photosystem II reaction center Z protein|
          Length = 62

 Score = 31.2 bits (69), Expect = 2.1
 Identities = 15/53 (28%), Positives = 31/53 (58%), Gaps = 1/53 (1%)
 Frame = +3

Query: 21  YSIIGFGDILLPGLVVAFALRYDWAAKKSMR-SGYFLWSASAYGTGLLITYVA 176
           +++I    +L+ G+ VA A    W++ K++  SG  LW  S +  G+L ++++
Sbjct: 10  FALIAISTLLVIGVPVALASPNGWSSNKNVLFSGVSLWIGSVFLVGILNSFIS 62

>CABL1_HUMAN (Q8TDN4) CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1)|
           (Ik3-1)
          Length = 633

 Score = 30.4 bits (67), Expect = 3.5
 Identities = 17/34 (50%), Positives = 19/34 (55%)
 Frame = +2

Query: 233 PGHADLAGVEEGGAAEPVAQGGAGPRVHPSGLRA 334
           P  A+  G EEGGAA+P A G  G R   S L A
Sbjct: 80  PQDAEWGGGEEGGAAKPGAGGACGARTRFSLLAA 113

>LMP1_EBV (P03230) Latent membrane protein 1 (LMP-1) (Protein p63) [Contains:|
           Protein p25]
          Length = 386

 Score = 29.6 bits (65), Expect = 6.0
 Identities = 19/47 (40%), Positives = 24/47 (51%)
 Frame = +3

Query: 156 LLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLWLKG 296
           L+IT + + L + HGQ   L IV F  G L+ LG     L  LW  G
Sbjct: 88  LMITLLLIALWNLHGQALFLGIVLFIFGCLLVLGIWIYLLEMLWRLG 134

>Y173_LACJO (P60927) UPF0078 membrane protein LJ_0173|
          Length = 206

 Score = 29.3 bits (64), Expect = 7.9
 Identities = 16/50 (32%), Positives = 27/50 (54%)
 Frame = +3

Query: 120 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRG 269
           +F W A      LLI    + +M     P L+Y++ F++ T I+ GW++G
Sbjct: 116 FFDWRAGLIA--LLIGLFLVIIMKNLTIPPLVYMLGFSIFTWINFGWEQG 163

>LMP1_EBVR (P13198) Latent membrane protein 1 (LMP-1) (Protein p63)|
          Length = 386

 Score = 29.3 bits (64), Expect = 7.9
 Identities = 19/47 (40%), Positives = 24/47 (51%)
 Frame = +3

Query: 156 LLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLWLKG 296
           L+IT + + L + HGQ   L IV F  G L+ LG     L  LW  G
Sbjct: 88  LMITLLLIALWNLHGQALYLGIVLFIFGCLLVLGLWIYLLEILWRLG 134


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,161,377
Number of Sequences: 219361
Number of extensions: 1869185
Number of successful extensions: 5994
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 5662
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5965
length of database: 80,573,946
effective HSP length: 105
effective length of database: 57,541,041
effective search space used: 4545742239
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)