ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
menu 
| Clone Name | baak4n16 |
|---|---|
| Clone Library Name | barley_pub |
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 162 bits (409), Expect(2) = 1e-40 Identities = 74/147 (50%), Positives = 106/147 (72%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 IAVKRLSK+S QG +E NE+ L+A+L+H NLV+++G C+E E++L+YE++ N SLD Sbjct: 553 IAVKRLSKTSVQGTDEFMNEVTLIARLQHINLVQVLGCCIEGDEKMLIYEYLENLSLDSY 612 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 LF + +L+W L YLH+DS+ +++HRDLK SN+LLD +M PKISDF Sbjct: 613 LFGKTRRSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDF 672 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAP 441 G+AR+F R +T+ T +V+GTYGYM+P Sbjct: 673 GMARIFERDETEANTMKVVGTYGYMSP 699 Score = 23.9 bits (50), Expect(2) = 1e-40 Identities = 10/11 (90%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DVFSFGV+VLE Sbjct: 712 DVFSFGVIVLE 722
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 124 bits (312), Expect(2) = 1e-28 Identities = 64/148 (43%), Positives = 90/148 (60%), Gaps = 1/148 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK+L ++ QG E E+ +++ L H NLV L+G C + +RLLVYEF+P SL+ Sbjct: 112 VAVKQLDRNGLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDH 171 Query: 181 LFDTEKG-EQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L D E LDW L++LH+ + V++RD K+SN+LLD +PK+SD Sbjct: 172 LHDLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSD 231 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAP 441 FGLA+L G V+ RV+GTYGY AP Sbjct: 232 FGLAKLGPTGDKSHVSTRVMGTYGYCAP 259 Score = 20.8 bits (42), Expect(2) = 1e-28 Identities = 8/11 (72%), Positives = 10/11 (90%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DV+SFGV+ LE Sbjct: 272 DVYSFGVVFLE 282
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 124 bits (310), Expect(2) = 2e-28 Identities = 62/148 (41%), Positives = 89/148 (60%), Gaps = 1/148 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+L ++ QG+ E E+ ++ H NLV+L+G C E +RLLVYE++P SL+ Sbjct: 129 VAIKQLDRNGVQGIREFVVEVLTLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDH 188 Query: 181 LFDTEKGEQ-LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L G++ LDW L+YLH+ V++RDLK SN+LL D PK+SD Sbjct: 189 LHVLPSGKKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSD 248 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAP 441 FGLA++ G V+ RV+GTYGY AP Sbjct: 249 FGLAKVGPSGDKTHVSTRVMGTYGYCAP 276 Score = 21.2 bits (43), Expect(2) = 2e-28 Identities = 7/11 (63%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 D++SFGV++LE Sbjct: 289 DIYSFGVVLLE 299
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 122 bits (305), Expect(2) = 5e-28 Identities = 63/147 (42%), Positives = 91/147 (61%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+KRL+ S QG E ++E+ + L H+NLV+L+G C E +E LLVYEF+P SL+ Sbjct: 121 VAIKRLNSESVQGFAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESH 180 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 LF + + W L +LH Q +V++RD KASN+LLD++ + K+SDF Sbjct: 181 LF--RRNDPFPWDLRIKIVIGAARGLAFLH-SLQREVIYRDFKASNILLDSNYDAKLSDF 237 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAP 441 GLA+L + VT R++GTYGY AP Sbjct: 238 GLAKLGPADEKSHVTTRIMGTYGYAAP 264 Score = 21.6 bits (44), Expect(2) = 5e-28 Identities = 8/11 (72%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DVF+FGV++LE Sbjct: 277 DVFAFGVVLLE 287
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 120 bits (300), Expect(2) = 2e-27 Identities = 64/148 (43%), Positives = 90/148 (60%), Gaps = 1/148 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK+LS++ TQG E E+ + K+KH NLV L+G C +E+LLVYE++ N SLD Sbjct: 942 VAVKKLSEAKTQGNREFMAEMETLGKVKHPNLVSLLGYCSFSEEKLLVYEYMVNGSLDHW 1001 Query: 181 LFD-TEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L + T E LDW L +LH ++HRD+KASN+LLD D PK++D Sbjct: 1002 LRNQTGMLEVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKVAD 1061 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAP 441 FGLARL ++ V+ + GT+GY+ P Sbjct: 1062 FGLARLISACESH-VSTVIAGTFGYIPP 1088 Score = 21.6 bits (44), Expect(2) = 2e-27 Identities = 8/11 (72%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DV+SFGV++LE Sbjct: 1101 DVYSFGVILLE 1111
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 118 bits (295), Expect(3) = 3e-27 Identities = 68/151 (45%), Positives = 91/151 (60%), Gaps = 1/151 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 IAVKRL++ QG E E+ + +L H NLV+L+G CLE++ RLLVYEF+ SL+ Sbjct: 103 IAVKRLNQEGFQGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENH 162 Query: 181 LFDTEKGEQ-LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 LF Q L W L +LH ++Q +V++RD KASN+LLD++ N K+SD Sbjct: 163 LFRRGTFYQPLSWNTRVRMALGAARGLAFLH-NAQPQVIYRDFKASNILLDSNYNAKLSD 221 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 FGLAR G V+ RV+GT GY AP L Sbjct: 222 FGLARDGPMGDNSHVSTRVMGTQGYAAPEYL 252 Score = 21.6 bits (44), Expect(3) = 3e-27 Identities = 8/11 (72%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DV+SFGV++LE Sbjct: 262 DVYSFGVVLLE 272 Score = 21.6 bits (44), Expect(3) = 3e-27 Identities = 9/13 (69%), Positives = 10/13 (76%) Frame = +2 Query: 440 PEYLMRGNYSVKS 478 PEYL G+ SVKS Sbjct: 249 PEYLATGHLSVKS 261
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 117 bits (294), Expect = 1e-26 Identities = 64/151 (42%), Positives = 90/151 (59%), Gaps = 1/151 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 IAVK+L++ QG +E E+ + + H NLV+L+G CLE + RLLVYEF+P SL+ Sbjct: 104 IAVKKLNQDGWQGHQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENH 163 Query: 181 LFDTEKGEQ-LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 LF Q L W L +LH +++ V++RD K SN+LLD++ N K+SD Sbjct: 164 LFRRGSYFQPLSWTLRLKVALGAAKGLAFLH-NAETSVIYRDFKTSNILLDSEYNAKLSD 222 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 FGLA+ G V+ R++GTYGY AP L Sbjct: 223 FGLAKDGPTGDKSHVSTRIMGTYGYAAPEYL 253
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 115 bits (289), Expect(2) = 3e-26 Identities = 64/153 (41%), Positives = 93/153 (60%), Gaps = 3/153 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 IAVK+L++ QG +E E+ + + H++LV+L+G CLE + RLLVYEF+P SL+ Sbjct: 103 IAVKKLNQDGWQGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENH 162 Query: 181 LFDTEKG---EQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 LF +G + L W L +LH S+ +V++RD K SN+LLD++ N K+ Sbjct: 163 LF--RRGLYFQPLSWKLRLKVALGAAKGLAFLHS-SETRVIYRDFKTSNILLDSEYNAKL 219 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 SDFGLA+ G V+ RV+GT+GY AP L Sbjct: 220 SDFGLAKDGPIGDKSHVSTRVMGTHGYAAPEYL 252 Score = 21.6 bits (44), Expect(2) = 3e-26 Identities = 8/11 (72%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DV+SFGV++LE Sbjct: 262 DVYSFGVVLLE 272
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 115 bits (288), Expect = 7e-26 Identities = 59/148 (39%), Positives = 87/148 (58%), Gaps = 1/148 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+L S QG E E+ + K+KH+NLV L+G C ERLLVYEF+ SL+ + Sbjct: 908 VAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDV 967 Query: 181 LFDTEK-GEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L D +K G +L+W L +LH + ++HRD+K+SNVLLD ++ ++SD Sbjct: 968 LHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSD 1027 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAP 441 FG+ARL T + + GT GY+ P Sbjct: 1028 FGMARLMSAMDTHLSVSTLAGTPGYVPP 1055
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 113 bits (283), Expect(2) = 3e-25 Identities = 61/151 (40%), Positives = 95/151 (62%), Gaps = 4/151 (2%) Frame = +1 Query: 1 IAVKRLSKS--STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 IAVKR+ + +G E K+E+A++ K++H++LV L+G CL+ E+LLVYE++P +L Sbjct: 613 IAVKRMENGVIAGKGFAEFKSEIAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLS 672 Query: 175 QILFD-TEKG-EQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPK 348 + LF+ +E+G + L W ++YLH + +HRDLK SN+LL DM K Sbjct: 673 RHLFEWSEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAK 732 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAP 441 ++DFGL RL G+ + R+ GT+GY+AP Sbjct: 733 VADFGLVRLAPEGK-GSIETRIAGTFGYLAP 762 Score = 20.8 bits (42), Expect(2) = 3e-25 Identities = 7/11 (63%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DV+SFGV+++E Sbjct: 775 DVYSFGVILME 785
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 113 bits (282), Expect = 3e-25 Identities = 60/150 (40%), Positives = 87/150 (58%), Gaps = 3/150 (2%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+L + S QG E E+ + K+KH+NLV L+G C +ERLLVYEF+ SL+++ Sbjct: 863 VAIKKLIRLSCQGDREFMAEMETLGKIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEV 922 Query: 181 LFDTEKGEQ---LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 L GE+ L W L +LH + ++HRD+K+SNVLLD DM ++ Sbjct: 923 LHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARV 982 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAP 441 SDFG+ARL T + + GT GY+ P Sbjct: 983 SDFGMARLISALDTHLSVSTLAGTPGYVPP 1012
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 112 bits (281), Expect = 5e-25 Identities = 58/148 (39%), Positives = 88/148 (59%), Gaps = 1/148 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+L S QG E E+ + K+KH+NLV L+G C +ERLLVYE++ SL+ + Sbjct: 913 VAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDV 972 Query: 181 LFDTEK-GEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L D +K G +L+W L +LH + ++HRD+K+SNVLLD ++ ++SD Sbjct: 973 LHDRKKTGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSD 1032 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAP 441 FG+ARL T + + GT GY+ P Sbjct: 1033 FGMARLMSAMDTHLSVSTLAGTPGYVPP 1060
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 112 bits (281), Expect = 5e-25 Identities = 58/148 (39%), Positives = 88/148 (59%), Gaps = 1/148 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+L S QG E E+ + K+KH+NLV L+G C +ERLLVYE++ SL+ + Sbjct: 913 VAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDV 972 Query: 181 LFDTEK-GEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L D +K G +L+W L +LH + ++HRD+K+SNVLLD ++ ++SD Sbjct: 973 LHDRKKIGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSD 1032 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAP 441 FG+ARL T + + GT GY+ P Sbjct: 1033 FGMARLMSAMDTHLSVSTLAGTPGYVPP 1060
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 109 bits (272), Expect(2) = 1e-24 Identities = 60/156 (38%), Positives = 89/156 (57%), Gaps = 1/156 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-DQ 177 +AVK S +STQG E NEL L++ ++H+NLV L+G C E +++LVY F+ N SL D+ Sbjct: 621 VAVKVRSSTSTQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDR 680 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 + + K + LDW L YLH V+HRD+K+SN+LLD M K++D Sbjct: 681 LYGEASKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVAD 740 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAREL 465 FG ++ + V+ V GT GY+ P ++L Sbjct: 741 FGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQL 776 Score = 22.7 bits (47), Expect(2) = 1e-24 Identities = 9/11 (81%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DVFSFGV++LE Sbjct: 781 DVFSFGVVLLE 791
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 107 bits (268), Expect(2) = 4e-24 Identities = 60/156 (38%), Positives = 89/156 (57%), Gaps = 1/156 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-DQ 177 +AVK S +STQG E NEL L++ ++H+NLV L+G C E +++LVY F+ N SL D+ Sbjct: 620 VAVKVRSATSTQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDR 679 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 + + K + LDW L YLH V+HRD+K+SN+LLD M K++D Sbjct: 680 LYGEPAKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKVAD 739 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAREL 465 FG ++ + V+ V GT GY+ P ++L Sbjct: 740 FGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQL 775 Score = 22.7 bits (47), Expect(2) = 4e-24 Identities = 9/11 (81%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DVFSFGV++LE Sbjct: 780 DVFSFGVVLLE 790
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 109 bits (272), Expect = 5e-24 Identities = 61/147 (41%), Positives = 82/147 (55%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK+L ++ QG E + EL+++ ++ H NLVR+ G C E RLLV E+V N SL I Sbjct: 559 VAVKKL-ENVRQGKEVFQAELSVIGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANI 617 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 LF LDW L YLH + V+H D+K N+LLD PKI+DF Sbjct: 618 LFSEGGNILLDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDF 677 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAP 441 GL +L RG + + V GT GY+AP Sbjct: 678 GLVKLLNRGGSTQNVSHVRGTLGYIAP 704
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 108 bits (271), Expect = 7e-24 Identities = 58/149 (38%), Positives = 85/149 (57%), Gaps = 2/149 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+L + + QG E E+ + K+KH+NLV L+G C +ERLLVYE++ SL+ + Sbjct: 883 VAIKKLIQVTGQGDREFMAEMETIGKIKHRNLVPLLGYCKIGEERLLVYEYMKYGSLETV 942 Query: 181 LFDTEK--GEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + K G LDW L +LH ++HRD+K+SNVLLD D ++S Sbjct: 943 LHEKTKKGGIFLDWSARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDQDFVARVS 1002 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAP 441 DFG+ARL T + + GT GY+ P Sbjct: 1003 DFGMARLVSALDTHLSVSTLAGTPGYVPP 1031
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 107 bits (268), Expect = 1e-23 Identities = 56/147 (38%), Positives = 84/147 (57%), Gaps = 1/147 (0%) Frame = +1 Query: 4 AVKRLSKSSTQ-GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 AVK+L + + G + E+ + K++H+NL++L L ++ L++Y ++ N SL I Sbjct: 842 AVKKLVFTGIKNGSVSMVREIETIGKVRHRNLIKLEEFWLRKEYGLILYTYMENGSLHDI 901 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 L +T + LDW L YLH D +VHRD+K N+LLD+D+ P ISDF Sbjct: 902 LHETNPPKPLDWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDF 961 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAP 441 G+A+L + T +N V GT GYMAP Sbjct: 962 GIAKLLDQSATSIPSNTVQGTIGYMAP 988
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 107 bits (266), Expect = 2e-23 Identities = 56/150 (37%), Positives = 84/150 (56%), Gaps = 3/150 (2%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+L + + QG E E+ + K+KH+NLV L+G C +ERLLVYE++ SL+ + Sbjct: 884 VAIKKLIRITGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETV 943 Query: 181 LFDTEK---GEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 L + G L+W L +LH ++HRD+K+SNVLLD D ++ Sbjct: 944 LHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARV 1003 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAP 441 SDFG+ARL T + + GT GY+ P Sbjct: 1004 SDFGMARLVSALDTHLSVSTLAGTPGYVPP 1033
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 105 bits (263), Expect(2) = 3e-23 Identities = 59/152 (38%), Positives = 87/152 (57%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +AVKRL + TQG E + + E+ +++ H+NL+RL G C+ ERLLVY ++ N S+ Sbjct: 314 VAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVAS 373 Query: 178 ILFDTEKGEQ-LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + + + LDW L YLH+ K++HRD+KA+N+LLD + + Sbjct: 374 CLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVG 433 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLA+L T VT V GT G++AP L Sbjct: 434 DFGLAKLMDYKDTH-VTTAVRGTIGHIAPEYL 464 Score = 21.6 bits (44), Expect(2) = 3e-23 Identities = 8/11 (72%), Positives = 10/11 (90%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DVF +GVM+LE Sbjct: 474 DVFGYGVMLLE 484
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 102 bits (253), Expect(2) = 4e-22 Identities = 55/148 (37%), Positives = 83/148 (56%), Gaps = 1/148 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+LS Q E + E+ +++ +H NLV L G C + +RLL+Y ++ N SLD Sbjct: 759 VAIKKLSGDCGQIEREFEAEVETLSRAQHPNLVLLRGFCFYKNDRLLIYSYMENGSLDYW 818 Query: 181 LFDTEKGEQL-DWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L + G L W L YLHE ++HRD+K+SN+LLD + N ++D Sbjct: 819 LHERNDGPALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLAD 878 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAP 441 FGLARL +T V+ ++GT GY+ P Sbjct: 879 FGLARLMSPYETH-VSTDLVGTLGYIPP 905 Score = 21.6 bits (44), Expect(2) = 4e-22 Identities = 8/11 (72%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DV+SFGV++LE Sbjct: 918 DVYSFGVVLLE 928
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 100 bits (249), Expect(2) = 1e-21 Identities = 49/148 (33%), Positives = 84/148 (56%), Gaps = 1/148 (0%) Frame = +1 Query: 1 IAVKRL-SKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+KRL + + + E+ + +++H+++VRL+G + LL+YE++PN SL + Sbjct: 717 VAIKRLVGRGTGRSDHGFTAEIQTLGRIRHRHIVRLLGYVANKDTNLLLYEYMPNGSLGE 776 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 +L + KG L W L YLH D ++HRD+K++N+LLD+D ++D Sbjct: 777 LLHGS-KGGHLQWETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNNILLDSDFEAHVAD 835 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAP 441 FGLA+ G + + G+YGY+AP Sbjct: 836 FGLAKFLVDGAASECMSSIAGSYGYIAP 863 Score = 21.6 bits (44), Expect(2) = 1e-21 Identities = 8/11 (72%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DV+SFGV++LE Sbjct: 876 DVYSFGVVLLE 886
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 99.0 bits (245), Expect(2) = 4e-21 Identities = 54/148 (36%), Positives = 83/148 (56%), Gaps = 1/148 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+KRLS + Q E + E+ +++ +H NLV L+G C + ++LL+Y ++ N SLD Sbjct: 768 VAIKRLSGDTGQMDREFQAEVETLSRAQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYW 827 Query: 181 LFDTEKG-EQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L + G LDW L YLH+ + ++HRD+K+SN+LL ++D Sbjct: 828 LHEKVDGPPSLDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLSDTFVAHLAD 887 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAP 441 FGLARL T VT ++GT GY+ P Sbjct: 888 FGLARLILPYDTH-VTTDLVGTLGYIPP 914 Score = 21.6 bits (44), Expect(2) = 4e-21 Identities = 8/11 (72%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DV+SFGV++LE Sbjct: 927 DVYSFGVVLLE 937
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 98.2 bits (243), Expect(2) = 6e-21 Identities = 56/151 (37%), Positives = 87/151 (57%), Gaps = 4/151 (2%) Frame = +1 Query: 1 IAVKRLSKSST--QGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVKR K+S + +E NEL L+++L H +L+ L+G C + ERLLVYEF+ + SL Sbjct: 530 VAVKRAIKASDVKKSSKEFHNELDLLSRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLY 589 Query: 175 QILF--DTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPK 348 Q L D ++L+W ++YLH + V+HRD+K+SN+L+D D N + Sbjct: 590 QHLHGKDPNLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNAR 649 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAP 441 ++DFGL+ L ++ GT GY+ P Sbjct: 650 VADFGLSILGPADSGTPLSELPAGTLGYLDP 680 Score = 21.6 bits (44), Expect(2) = 6e-21 Identities = 8/11 (72%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DV+SFGV++LE Sbjct: 693 DVYSFGVVLLE 703
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 98.6 bits (244), Expect = 9e-21 Identities = 52/155 (33%), Positives = 85/155 (54%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK LS+ S QG +E + E+ L+ ++ H NL LVG C E +L+YE++ N +L Sbjct: 598 VAVKVLSEESAQGYKEFRAEVDLLMRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDY 657 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 L ++ L W L+YLH + +VHRD+K +N+LL+ + K++DF Sbjct: 658 LAG-KRSFILSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADF 716 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAREL 465 GL+R F + ++ V G+ GY+ P R++ Sbjct: 717 GLSRSFSVEGSGQISTVVAGSIGYLDPEYYSTRQM 751
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 97.8 bits (242), Expect(2) = 1e-20 Identities = 57/154 (37%), Positives = 82/154 (53%), Gaps = 4/154 (2%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKN----ELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS 168 +AVK+L EELK E+ ++A +H+NLV L+G + LVY ++PN S Sbjct: 210 VAVKKLGAMVEISTEELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGS 269 Query: 169 LDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPK 348 L L + L W +++LHE+ +HRD+K++N+LLD D K Sbjct: 270 LLDRLSCLDGTPPLSWHTRCKVAQGTANGIRFLHENHH---IHRDIKSANILLDKDFTAK 326 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 ISDFGLAR R +T+R++GT YMAP L Sbjct: 327 ISDFGLARASARLAQTVMTSRIVGTTAYMAPEAL 360 Score = 21.2 bits (43), Expect(2) = 1e-20 Identities = 7/11 (63%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 D++SFGV++LE Sbjct: 369 DIYSFGVVLLE 379
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 96.3 bits (238), Expect(2) = 3e-20 Identities = 56/160 (35%), Positives = 87/160 (54%), Gaps = 13/160 (8%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKN----------ELALVAKLKHKNLVRLVGVCLEQQERLLVYE 150 +AVK+L+KS G +E + E+ + ++HK++VRL C +LLVYE Sbjct: 708 VAVKKLNKSVKGGDDEYSSDSLNRDVFAAEVETLGTIRHKSIVRLWCCCSSGDCKLLVYE 767 Query: 151 FVPNRSLDQILF-DTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL 327 ++PN SL +L D + G L W L YLH D +VHRD+K+SN+LL Sbjct: 768 YMPNGSLADVLHGDRKGGVVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILL 827 Query: 328 DADMNPKISDFGLARL--FGRGQTQGVTNRVIGTYGYMAP 441 D+D K++DFG+A++ +T + + G+ GY+AP Sbjct: 828 DSDYGAKVADFGIAKVGQMSGSKTPEAMSGIAGSCGYIAP 867 Score = 21.2 bits (43), Expect(2) = 3e-20 Identities = 7/11 (63%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 D++SFGV++LE Sbjct: 880 DIYSFGVVLLE 890
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 94.0 bits (232), Expect(2) = 1e-19 Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 4/154 (2%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKN----ELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS 168 +AVK+L+ EELK E+ ++AK +H+NLV L+G + + LVY ++PN S Sbjct: 210 VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGS 269 Query: 169 LDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPK 348 L L + L W + +LHE+ +HRD+K++N+LLD K Sbjct: 270 LLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEAFTAK 326 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 ISDFGLAR + +T+R++GT YMAP L Sbjct: 327 ISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 360 Score = 21.2 bits (43), Expect(2) = 1e-19 Identities = 7/11 (63%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 D++SFGV++LE Sbjct: 369 DIYSFGVVLLE 379
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 85.1 bits (209), Expect(2) = 3e-17 Identities = 54/156 (34%), Positives = 78/156 (50%), Gaps = 12/156 (7%) Frame = +1 Query: 4 AVKRLSKSS----TQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 AVKRL + + T + E+ +++ +H N+V G C E LVY F+PN SL Sbjct: 237 AVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSL 296 Query: 172 -DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPK 348 DQ+ T+ L W +Q+LH+DS ++H D+K+SNVLLD + PK Sbjct: 297 EDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLMPK 355 Query: 349 ISDFGLARL-------FGRGQTQGVTNRVIGTYGYM 435 + DFGLAR + T T+ V GT Y+ Sbjct: 356 LGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYL 391 Score = 21.9 bits (45), Expect(2) = 3e-17 Identities = 8/11 (72%), Positives = 10/11 (90%) Frame = +3 Query: 480 DVFSFGVMVLE 512 D FSFGV++LE Sbjct: 406 DTFSFGVVILE 416
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 80.1 bits (196), Expect(2) = 8e-16 Identities = 53/156 (33%), Positives = 79/156 (50%), Gaps = 12/156 (7%) Frame = +1 Query: 4 AVKRLSKSS----TQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 AVKRL +++ T + E+ +++ +H N+V G C + LVY F+PN SL Sbjct: 237 AVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSL 296 Query: 172 -DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPK 348 D++ T+ L W +Q+LH+DS ++H D+K+SNVLLD + PK Sbjct: 297 EDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTPK 355 Query: 349 ISDFGLA---RLFGRGQTQGV----TNRVIGTYGYM 435 + DFGLA R G +Q T V GT Y+ Sbjct: 356 LGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL 391 Score = 22.3 bits (46), Expect(2) = 8e-16 Identities = 9/11 (81%), Positives = 10/11 (90%) Frame = +3 Query: 480 DVFSFGVMVLE 512 D FSFGV+VLE Sbjct: 406 DTFSFGVVVLE 416
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 80.5 bits (197), Expect = 2e-15 Identities = 50/150 (33%), Positives = 81/150 (54%), Gaps = 8/150 (5%) Frame = +1 Query: 31 TQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQL 210 +Q +E ++ E L A LKH N++ L GVCL++ LV EF L+++L G+++ Sbjct: 182 SQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL----SGKRI 237 Query: 211 DWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL-----DADMNP---KISDFGL 366 + YLH+++ + ++HRDLK+SN+L+ + D++ KI+DFGL Sbjct: 238 PPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGL 297 Query: 367 ARLFGRGQTQGVTNRVIGTYGYMAPGVLDA 456 AR + R GTY +MAP V+ A Sbjct: 298 AREWHRTTKMSAA----GTYAWMAPEVIRA 323
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 75.5 bits (184), Expect = 8e-14 Identities = 45/128 (35%), Positives = 72/128 (56%), Gaps = 4/128 (3%) Frame = +1 Query: 1 IAVKRL-SKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L S SS + E E ++ + H N++RL+GV + ++V E++ N SLDQ Sbjct: 745 VAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQ 804 Query: 178 ILFDT-EKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVH--RDLKASNVLLDADMNPK 348 L +T ++GE++ W ++YL + + V RDL A NVLLD ++ K Sbjct: 805 FLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRVSFLRDLAARNVLLDMELRCK 864 Query: 349 ISDFGLAR 372 I+DFGL+R Sbjct: 865 IADFGLSR 872
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 73.9 bits (180), Expect = 2e-13 Identities = 45/152 (29%), Positives = 79/152 (51%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK+L K ++ E +++ L H+N+++ GV LE +V E+ SL Sbjct: 42 VAVKKLLK--------IEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDY 93 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 + ++ + E++D + YLH ++ +KV+HRDLK+ NV++ AD KI DF Sbjct: 94 I-NSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDF 152 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAPGVLDA 456 G +R ++GT+ +MAP V+ + Sbjct: 153 GASRFHNHTTHMS----LVGTFPWMAPEVIQS 180
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 73.9 bits (180), Expect = 2e-13 Identities = 45/152 (29%), Positives = 79/152 (51%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK+L K ++ E +++ L H+N+++ GV LE +V E+ SL Sbjct: 42 VAVKKLLK--------IEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDY 93 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 + ++ + E++D + YLH ++ +KV+HRDLK+ NV++ AD KI DF Sbjct: 94 I-NSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDF 152 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAPGVLDA 456 G +R ++GT+ +MAP V+ + Sbjct: 153 GASRFHNHTTHMS----LVGTFPWMAPEVIQS 180
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 73.6 bits (179), Expect = 3e-13 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLSKSS--TQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK L + + V E E+A++ +L+H N+V +G + +V E++ SL Sbjct: 575 VAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLY 634 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 ++L + EQLD + YLH + +VHRDLK+ N+L+D K+ Sbjct: 635 RLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNP-PIVHRDLKSPNLLVDKKYTVKVC 693 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGL+RL + T + GT +MAP VL Sbjct: 694 DFGLSRL--KASTFLSSKSAAGTPEWMAPEVL 723
>CIPK1_ORYSA (Q6X4A2) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1)| Length = 449 Score = 73.2 bits (178), Expect = 4e-13 Identities = 49/156 (31%), Positives = 78/156 (50%), Gaps = 3/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQG---VEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +A+K L K Q VE+++ E+ + +KH N+VRL V + +V E+V L Sbjct: 46 VAIKILDKEKVQKHRLVEQIRREICTMKLVKHPNVVRLFEVMGSKARIFIVLEYVTGGEL 105 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 +I+ + ++ + + Y H V HRDLK N+LLDA N K+ Sbjct: 106 FEIIATNGRLKEEE---ARKYFQQLINAVDYCHSRG---VYHRDLKLENLLLDASGNLKV 159 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 SDFGL+ L + + G+ + GT Y+AP V++ R Sbjct: 160 SDFGLSALTEQVKADGLLHTTCGTPNYVAPEVIEDR 195
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 71.2 bits (173), Expect = 2e-12 Identities = 43/152 (28%), Positives = 79/152 (51%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE--ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK+ K + E + E+A +++LKH N+V +G C+++ +V E++ +L Sbjct: 1388 VAVKKFVKQKLSETQLLEFRAEMAFLSELKHSNIVTFIGACIKKPNICIVTEYMRMGNLR 1447 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 +L + + ++ + + YLH + + +VHRD+K +N+L+D N KI+ Sbjct: 1448 DVLKNPDI--KITFANKLKLLYGAAMGIDYLHSSNPM-IVHRDIKPANILVDEHFNVKIA 1504 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFG AR+ + T GT + AP V+ Sbjct: 1505 DFGFARI----KEDNTTMTRCGTPCWTAPEVI 1532 Score = 65.9 bits (159), Expect = 6e-11 Identities = 42/151 (27%), Positives = 74/151 (49%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 I+ K +SK + E E+ ++ L+H N+V + + +V EF+ SL + Sbjct: 815 ISSKHVSKDMERSFFE---EVKIMTSLRHPNVVLFMAASTKSPNMCIVMEFMSLGSLYDL 871 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 L E ++ + + +LH +VHRDLK+ N+LLD+ N K+SDF Sbjct: 872 L-GNELIPEIPYALKIKMAYQASKGMHFLHSSG---IVHRDLKSLNLLLDSKWNVKVSDF 927 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAPGVLD 453 GL ++ + + +IGT ++AP +L+ Sbjct: 928 GLTKVKSELDKKKTNDNIIGTIHWIAPEILN 958
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 70.9 bits (172), Expect = 2e-12 Identities = 52/173 (30%), Positives = 79/173 (45%), Gaps = 23/173 (13%) Frame = +1 Query: 1 IAVKRLSKSSTQ----GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS 168 +AVK + Q E ++ E L A L+H N++ L GVCL+Q LV EF + Sbjct: 148 VAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGA 207 Query: 169 LDQILF-----------DTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKAS 315 L++ L + ++ + YLHE++ + ++HRDLK+S Sbjct: 208 LNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSS 267 Query: 316 NVLL--------DADMNPKISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 N+LL + KI+DFGLAR + R GTY +MAP V+ Sbjct: 268 NILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTA----GTYAWMAPEVI 316
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 70.1 bits (170), Expect = 3e-12 Identities = 42/153 (27%), Positives = 77/153 (50%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K + + + + ++ E++L+ L H N+V+ G + E ++ E+ N SL ++ Sbjct: 51 VAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRL 110 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 + + G L L+YLH + V+HRD+KA+N+LL AD K++DF Sbjct: 111 ISRSSTG--LSENESKTYVTQTLLGLKYLHGEG---VIHRDIKAANILLSADNTVKLADF 165 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 G++ + + GT +MAP +L R Sbjct: 166 GVSTIVNSSAL-----TLAGTLNWMAPEILGNR 193
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 69.7 bits (169), Expect = 4e-12 Identities = 47/151 (31%), Positives = 73/151 (48%), Gaps = 1/151 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQG-VEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 IA SK TQ ++EL+ E+ L+ L H N+VR +G E ++ EFVP S+ Sbjct: 102 IAANFASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDDTLNILLEFVPGGSISS 161 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 +L EK L+YLH + ++HRD+K +N+L+D K++D Sbjct: 162 LL---EKFGPFPESVVRTYTRQLLLGLEYLHNHA---IMHRDIKGANILVDNKGCIKLAD 215 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 FG ++ T + GT +MAP V+ Sbjct: 216 FGASKQVAELATMTGAKSMKGTPYWMAPEVI 246
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 69.7 bits (169), Expect = 4e-12 Identities = 43/127 (33%), Positives = 69/127 (54%), Gaps = 2/127 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQER--LLVYEFVPNRSLD 174 +A K L S + E+ E ++ KL+H+ +V L+GVC E Q+ L++ E++ N SL Sbjct: 245 VAAKMLQSSKAER-EKFVLEAKIMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLK 303 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L T G++ + + YL + KVVHRDL+A N+L+ D+ K++ Sbjct: 304 EYL-KTPDGKKTNLNQMVHMMAEISEGMAYLESE---KVVHRDLRADNILVANDLTRKVA 359 Query: 355 DFGLARL 375 DFGL L Sbjct: 360 DFGLTEL 366
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 68.9 bits (167), Expect = 7e-12 Identities = 47/151 (31%), Positives = 73/151 (48%), Gaps = 1/151 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQG-VEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 IA SK TQG + EL+ E+ L+ L H N+VR +G E ++ EFVP S+ Sbjct: 101 IAPSSASKEKTQGHIRELEEEVQLLKNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISS 160 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 +L EK L+YLH + ++HRD+K +N+L+D +++D Sbjct: 161 LL---EKFGSFPEPVIIMYTKQLLLGLEYLHNNG---IMHRDIKGANILVDNKGCIRLAD 214 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 FG ++ T + GT +MAP V+ Sbjct: 215 FGASKKVVELATVNGAKSMKGTPYWMAPEVI 245
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 68.9 bits (167), Expect = 7e-12 Identities = 45/145 (31%), Positives = 72/145 (49%), Gaps = 1/145 (0%) Frame = +1 Query: 19 SKSSTQG-VEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTE 195 SK TQ ++EL+ E+ L+ L H N+VR +G E + ++ EFVP S+ +L E Sbjct: 107 SKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDETLNILLEFVPGGSISSLL---E 163 Query: 196 KGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARL 375 K L+YLH + ++HRD+K +N+L+D K++DFG ++ Sbjct: 164 KFGAFPESVVRTYTNQLLLGLEYLHNHA---IMHRDIKGANILVDNQGCIKLADFGASKQ 220 Query: 376 FGRGQTQGVTNRVIGTYGYMAPGVL 450 T + GT +MAP V+ Sbjct: 221 VAELATISGAKSMKGTPYWMAPEVI 245
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 68.6 bits (166), Expect = 1e-11 Identities = 45/150 (30%), Positives = 73/150 (48%) Frame = +1 Query: 10 KRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFD 189 K L+KS QG ++ E++ + L+H ++++L V + E ++V E+ N D I+ Sbjct: 73 KVLAKSDMQG--RIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQR 130 Query: 190 TEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLA 369 + EQ ++Y H K+VHRDLK N+LLD +N KI+DFGL+ Sbjct: 131 NKMSEQ----EARRFFQQIISAVEYCHRH---KIVHRDLKPENLLLDEHLNVKIADFGLS 183 Query: 370 RLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 + G G+ Y AP V+ + Sbjct: 184 NIMTDG---NFLKTSCGSPNYAAPEVISGK 210
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 68.6 bits (166), Expect = 1e-11 Identities = 51/164 (31%), Positives = 77/164 (46%), Gaps = 12/164 (7%) Frame = +1 Query: 1 IAVKRLSKSSTQGV----EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS 168 +AVK + + + E ++ E L A L H N++ L VCLE+ LV E+ Sbjct: 141 VAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGP 200 Query: 169 LDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL-----DA 333 L + L G ++ + YLH ++ + V+HRDLK++N+LL Sbjct: 201 LSRAL----AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESD 256 Query: 334 DMNP---KISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDA 456 DM KI+DFGLAR + + GTY +MAP V+ A Sbjct: 257 DMEHKTLKITDFGLAREWHKTTQMSAA----GTYAWMAPEVIKA 296
>SNF1_YEAST (P06782) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 633 Score = 68.2 bits (165), Expect = 1e-11 Identities = 45/150 (30%), Positives = 73/150 (48%) Frame = +1 Query: 10 KRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFD 189 K L+KS QG ++ E++ + L+H ++++L V + E ++V E+ N D I+ Sbjct: 89 KVLAKSDMQG--RIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQR 146 Query: 190 TEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLA 369 + EQ ++Y H K+VHRDLK N+LLD +N KI+DFGL+ Sbjct: 147 DKMSEQ----EARRFFQQIISAVEYCHRH---KIVHRDLKPENLLLDEHLNVKIADFGLS 199 Query: 370 RLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 + G G+ Y AP V+ + Sbjct: 200 NIMTDG---NFLKTSCGSPNYAAPEVISGK 226
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 68.2 bits (165), Expect = 1e-11 Identities = 53/154 (34%), Positives = 81/154 (52%), Gaps = 5/154 (3%) Frame = +1 Query: 4 AVKRLSKSSTQGVEE-LKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-DQ 177 AVK + K + +G E ++NE+A++ K+KH+N+V L + LV + V L D+ Sbjct: 50 AVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDR 109 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL---DADMNPK 348 I+ EKG + + YLH ++ +VHRDLK N+L D + Sbjct: 110 IV---EKGFYTE-KDASTLIRQVLDAVYYLH---RMGIVHRDLKPENLLYYSQDEESKIM 162 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 ISDFGL+++ G+G V + GT GY+AP VL Sbjct: 163 ISDFGLSKMEGKGD---VMSTACGTPGYVAPEVL 193
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 68.2 bits (165), Expect = 1e-11 Identities = 53/154 (34%), Positives = 81/154 (52%), Gaps = 5/154 (3%) Frame = +1 Query: 4 AVKRLSKSSTQGVEE-LKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-DQ 177 AVK + K + +G E ++NE+A++ K+KH+N+V L + LV + V L D+ Sbjct: 50 AVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDR 109 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL---DADMNPK 348 I+ EKG + + YLH ++ +VHRDLK N+L D + Sbjct: 110 IV---EKGFYTE-KDASTLIRQVLDAVYYLH---RMGIVHRDLKPENLLYYSQDEESKIM 162 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 ISDFGL+++ G+G V + GT GY+AP VL Sbjct: 163 ISDFGLSKMEGKGD---VMSTACGTPGYVAPEVL 193
>AVR2B_BOVIN (Q95126) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 68.2 bits (165), Expect = 1e-11 Identities = 53/164 (32%), Positives = 75/164 (45%), Gaps = 13/164 (7%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLV-----GVCLEQQERLLVYEFVPNR 165 +AVK Q + + E+ +KH+NL++ + G LE E L+ F Sbjct: 214 VAVKIFPLQDKQSWQS-EREIFSTPGMKHENLLQFIAAEKRGSSLEA-ELWLITAFHDKG 271 Query: 166 SLDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHED--------SQLKVVHRDLKASNV 321 SL L KG + W L YLHED + + HRD K+ NV Sbjct: 272 SLTDYL----KGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNV 327 Query: 322 LLDADMNPKISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLD 453 LL +D+ ++DFGLA F G+ G T+ +GT YMAP VL+ Sbjct: 328 LLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLE 371
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 67.8 bits (164), Expect = 2e-11 Identities = 41/127 (32%), Positives = 70/127 (55%), Gaps = 3/127 (2%) Frame = +1 Query: 1 IAVKRLSKS-STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L ++ S + ++ K E+ L++ LKH+N+V ++GV L ++ +++E++ N L + Sbjct: 439 VAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHE 498 Query: 178 ILFDTE--KGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 L +G+ L +QYL S VHRDL A N L++ + KI Sbjct: 499 FLISNSPTEGKSLSQLEFLQIALQISEGMQYL---SAHHYVHRDLAARNCLVNEGLVVKI 555 Query: 352 SDFGLAR 372 SDFGL+R Sbjct: 556 SDFGLSR 562
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 67.8 bits (164), Expect = 2e-11 Identities = 49/152 (32%), Positives = 83/152 (54%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ +S +GV E++L+ +LKH N+VRL+ V +++ L++EF+ + L Sbjct: 30 VAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLLDVLMQESRLYLIFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ +D + + H + +V+HRDLK N+L+D K++ Sbjct: 89 KYLDSIPSGQYMDPMLVKSYLYQILEGIYFCH---RRRVLHRDLKPQNLLIDNKGVIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y AP VL Sbjct: 146 DFGLARAFG-VPVRVYTHEVV-TLWYRAPEVL 175
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 67.8 bits (164), Expect = 2e-11 Identities = 49/152 (32%), Positives = 83/152 (54%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ +S +GV E++L+ +LKH N+VRL+ V +++ L++EF+ + L Sbjct: 30 VAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLLDVLMQESRLYLIFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ +D + + H + +V+HRDLK N+L+D K++ Sbjct: 89 KYLDSIPSGQYMDPMLVKSYLYQILEGIYFCH---RRRVLHRDLKPQNLLIDNKGVIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y AP VL Sbjct: 146 DFGLARAFG-VPVRVYTHEVV-TLWYRAPEVL 175
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 67.8 bits (164), Expect = 2e-11 Identities = 49/152 (32%), Positives = 83/152 (54%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ +S +GV E++L+ +LKH N+VRL+ V +++ L++EF+ + L Sbjct: 30 VAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLLDVLMQESRLYLIFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ +D + + H + +V+HRDLK N+L+D K++ Sbjct: 89 KYLDSIPSGQYMDPMLVKSYLYQILEGIYFCH---RRRVLHRDLKPQNLLIDNKGVIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y AP VL Sbjct: 146 DFGLARAFG-VPVRVYTHEVV-TLWYRAPEVL 175
>KCC1A_RAT (Q63450) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 67.8 bits (164), Expect = 2e-11 Identities = 53/155 (34%), Positives = 82/155 (52%), Gaps = 5/155 (3%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-D 174 +A+K ++K + +G E ++NE+A++ K+KH N+V L + L+ + V L D Sbjct: 46 VAIKCIAKKALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFD 105 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVL---LDADMNP 345 +I+ EKG + ++YLH+ L +VHRDLK N+L LD D Sbjct: 106 RIV---EKGFYTE-RDASRLIFQVLDAVKYLHD---LGIVHRDLKPENLLYYSLDEDSKI 158 Query: 346 KISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 ISDFGL+++ G V + GT GY+AP VL Sbjct: 159 MISDFGLSKMEDPG---SVLSTACGTPGYVAPEVL 190
>KCC1A_MOUSE (Q91YS8) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 67.8 bits (164), Expect = 2e-11 Identities = 53/155 (34%), Positives = 82/155 (52%), Gaps = 5/155 (3%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-D 174 +A+K ++K + +G E ++NE+A++ K+KH N+V L + L+ + V L D Sbjct: 46 VAIKCIAKKALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFD 105 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVL---LDADMNP 345 +I+ EKG + ++YLH+ L +VHRDLK N+L LD D Sbjct: 106 RIV---EKGFYTE-RDASRLIFQVLDAVKYLHD---LGIVHRDLKPENLLYYSLDEDSKI 158 Query: 346 KISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 ISDFGL+++ G V + GT GY+AP VL Sbjct: 159 MISDFGLSKMEDPG---SVLSTACGTPGYVAPEVL 190
>AVR2B_RAT (P38445) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 513 Score = 67.8 bits (164), Expect = 2e-11 Identities = 51/164 (31%), Positives = 74/164 (45%), Gaps = 13/164 (7%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLV-----GVCLEQQERLLVYEFVPNR 165 +AVK Q + + E+ +KH+NL++ + G + E L+ F Sbjct: 214 VAVKIFPLQDKQSWQS-EREIFSTPGMKHENLLQFIAAEKRGCSNLEVELWLITAFHDKG 272 Query: 166 SLDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHED--------SQLKVVHRDLKASNV 321 SL L KG + W L YLHED + + HRD K+ NV Sbjct: 273 SLTDYL----KGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNV 328 Query: 322 LLDADMNPKISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLD 453 LL +D+ ++DFGLA F G+ G T+ +GT YMAP VL+ Sbjct: 329 LLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLE 372
>KCC1A_HUMAN (Q14012) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 370 Score = 67.8 bits (164), Expect = 2e-11 Identities = 53/155 (34%), Positives = 82/155 (52%), Gaps = 5/155 (3%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-D 174 +A+K ++K + +G E ++NE+A++ K+KH N+V L + L+ + V L D Sbjct: 46 VAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFD 105 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVL---LDADMNP 345 +I+ EKG + ++YLH+ L +VHRDLK N+L LD D Sbjct: 106 RIV---EKGFYTE-RDASRLIFQVLDAVKYLHD---LGIVHRDLKPENLLYYSLDEDSKI 158 Query: 346 KISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 ISDFGL+++ G V + GT GY+AP VL Sbjct: 159 MISDFGLSKMEDPG---SVLSTACGTPGYVAPEVL 190
>M3K1_RAT (Q62925) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1493 Score = 67.4 bits (163), Expect = 2e-11 Identities = 47/164 (28%), Positives = 82/164 (50%), Gaps = 3/164 (1%) Frame = +1 Query: 7 VKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILF 186 V+ S + VE L+ E+ +++ L H N++R++G E+ L E++ S+ +L Sbjct: 1258 VRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGASVAHLL- 1316 Query: 187 DTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDA-DMNPKISDFG 363 K L YLHE+ +++HRD+K +N+L+D+ +I+DFG Sbjct: 1317 --SKYGAFKESVVINYTEQLLRGLSYLHEN---QIIHRDVKGANLLIDSTGQRLRIADFG 1371 Query: 364 -LARLFGRGQTQG-VTNRVIGTYGYMAPGVLDARELLREIGMCS 489 ARL +G G +++GT +MAP VL ++ R + S Sbjct: 1372 AAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWS 1415
>AVR2B_PIG (Q66T47) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 67.0 bits (162), Expect = 3e-11 Identities = 53/164 (32%), Positives = 75/164 (45%), Gaps = 13/164 (7%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLV-----GVCLEQQERLLVYEFVPNR 165 +AVK Q + + E+ +KH+NL++ + G LE E L+ F Sbjct: 214 VAVKIFPLQDKQSWQS-EREIFSTPGMKHENLLQFIAAEKRGSNLEV-ELWLITAFHDKG 271 Query: 166 SLDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHED--------SQLKVVHRDLKASNV 321 SL L KG + W L YLHED + + HRD K+ NV Sbjct: 272 SLTDYL----KGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNV 327 Query: 322 LLDADMNPKISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLD 453 LL +D+ ++DFGLA F G+ G T+ +GT YMAP VL+ Sbjct: 328 LLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLE 371
>AVR2B_HUMAN (Q13705) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 67.0 bits (162), Expect = 3e-11 Identities = 53/164 (32%), Positives = 75/164 (45%), Gaps = 13/164 (7%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLV-----GVCLEQQERLLVYEFVPNR 165 +AVK Q + + E+ +KH+NL++ + G LE E L+ F Sbjct: 214 VAVKIFPLQDKQSWQS-EREIFSTPGMKHENLLQFIAAEKRGSNLEV-ELWLITAFHDKG 271 Query: 166 SLDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHED--------SQLKVVHRDLKASNV 321 SL L KG + W L YLHED + + HRD K+ NV Sbjct: 272 SLTDYL----KGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNV 327 Query: 322 LLDADMNPKISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLD 453 LL +D+ ++DFGLA F G+ G T+ +GT YMAP VL+ Sbjct: 328 LLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLE 371
>AVR2B_MOUSE (P27040) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 536 Score = 67.0 bits (162), Expect = 3e-11 Identities = 53/164 (32%), Positives = 75/164 (45%), Gaps = 13/164 (7%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLV-----GVCLEQQERLLVYEFVPNR 165 +AVK Q + + E+ +KH+NL++ + G LE E L+ F Sbjct: 238 VAVKIFPLQDKQSWQS-EREIFSTPGMKHENLLQFIAAEKRGSNLEV-ELWLITAFHDKG 295 Query: 166 SLDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHED--------SQLKVVHRDLKASNV 321 SL L KG + W L YLHED + + HRD K+ NV Sbjct: 296 SLTDYL----KGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNV 351 Query: 322 LLDADMNPKISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLD 453 LL +D+ ++DFGLA F G+ G T+ +GT YMAP VL+ Sbjct: 352 LLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLE 395
>M3K1_HUMAN (Q13233) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (Fragment) Length = 1495 Score = 67.0 bits (162), Expect = 3e-11 Identities = 47/164 (28%), Positives = 82/164 (50%), Gaps = 3/164 (1%) Frame = +1 Query: 7 VKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILF 186 V+ S + VE L+ E+ +++ L H N++R++G E+ L E++ S+ +L Sbjct: 1260 VRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLL- 1318 Query: 187 DTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDA-DMNPKISDFG 363 K L YLHE+ +++HRD+K +N+L+D+ +I+DFG Sbjct: 1319 --SKYGAFKESVVINYTEQLLRGLSYLHEN---QIIHRDVKGANLLIDSTGQRLRIADFG 1373 Query: 364 -LARLFGRGQTQG-VTNRVIGTYGYMAPGVLDARELLREIGMCS 489 ARL +G G +++GT +MAP VL ++ R + S Sbjct: 1374 AAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWS 1417
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 66.6 bits (161), Expect = 4e-11 Identities = 48/152 (31%), Positives = 83/152 (54%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ +S +GV E++L+ +LKH N+VRL+ V +++ L++EF+ + L Sbjct: 30 VAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLLDVLMQESRLYLIFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ +D + + H + +V+HRDLK N+L+D K++ Sbjct: 89 KYLDSIPSGQYMDPMLVKSYLYQILEGIYFCH---RRRVLHRDLKPQNLLIDNKGVIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGL+R FG + T+ V+ T Y AP VL Sbjct: 146 DFGLSRAFG-VPVRVYTHEVV-TLWYRAPEVL 175
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 66.6 bits (161), Expect = 4e-11 Identities = 44/144 (30%), Positives = 68/144 (47%), Gaps = 8/144 (5%) Frame = +1 Query: 43 EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXX 222 E++ E L L+H N++ L G CL LV E+ +L ++L G ++ Sbjct: 140 EQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL----AGRRVPPHV 195 Query: 223 XXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL--------DADMNPKISDFGLARLF 378 + YLH D+ + ++HRDLK+ N+L+ AD KI+DFGLAR + Sbjct: 196 LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREW 255 Query: 379 GRGQTQGVTNRVIGTYGYMAPGVL 450 + GTY +MAP V+ Sbjct: 256 HKTTKMSAA----GTYAWMAPEVI 275
>CHK1_RAT (Q91ZN7) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 66.6 bits (161), Expect = 4e-11 Identities = 51/160 (31%), Positives = 76/160 (47%), Gaps = 2/160 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-D 174 +AVK + K + E +K E+ + L H+N+V+ G E + L E+ L D Sbjct: 35 VAVKIVDMKRAIDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFD 94 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 +I D EQ + YLH + + HRD+K N+LLD N KIS Sbjct: 95 RIEPDIGMPEQ----DAQRFFHQLMAGVVYLHG---IGITHRDIKPENLLLDERDNLKIS 147 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLRE 474 DFGLA +F + + N++ GT Y+AP +L +E E Sbjct: 148 DFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAE 187
>CHK1_MOUSE (O35280) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 66.6 bits (161), Expect = 4e-11 Identities = 51/160 (31%), Positives = 76/160 (47%), Gaps = 2/160 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-D 174 +AVK + K + E +K E+ + L H+N+V+ G E + L E+ L D Sbjct: 35 VAVKIVDMKRAIDCPENIKKEICINKMLSHENVVKFYGHRREGHIQYLFLEYCSGGELFD 94 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 +I D EQ + YLH + + HRD+K N+LLD N KIS Sbjct: 95 RIEPDIGMPEQ----DAQRFFHQLMAGVVYLHG---IGITHRDIKPENLLLDERDNLKIS 147 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLRE 474 DFGLA +F + + N++ GT Y+AP +L +E E Sbjct: 148 DFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAE 187
>M3K1_MOUSE (P53349) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1493 Score = 66.6 bits (161), Expect = 4e-11 Identities = 47/164 (28%), Positives = 81/164 (49%), Gaps = 3/164 (1%) Frame = +1 Query: 7 VKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILF 186 V+ S + VE L+ E+ ++ L H N++R++G E+ L E++ S+ +L Sbjct: 1258 VRNTSSEQEEVVEALREEIRMMGHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLL- 1316 Query: 187 DTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDA-DMNPKISDFG 363 K L YLHE+ +++HRD+K +N+L+D+ +I+DFG Sbjct: 1317 --SKYGAFKESVVINYTEQLLRGLSYLHEN---QIIHRDVKGANLLIDSTGQRLRIADFG 1371 Query: 364 -LARLFGRGQTQG-VTNRVIGTYGYMAPGVLDARELLREIGMCS 489 ARL +G G +++GT +MAP VL ++ R + S Sbjct: 1372 AAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWS 1415
>KCC1G_HUMAN (Q96NX5) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 66.2 bits (160), Expect = 5e-11 Identities = 52/153 (33%), Positives = 80/153 (52%), Gaps = 4/153 (2%) Frame = +1 Query: 4 AVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-DQI 180 A+K + KS L+NE+A++ K+KH+N+V L + LV + V L D+I Sbjct: 50 ALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRI 109 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVL-LDADMNPK--I 351 L E+G + ++YLHE+ +VHRDLK N+L L + N K I Sbjct: 110 L---ERGVYTE-KDASLVIQQVLSAVKYLHENG---IVHRDLKPENLLYLTPEENSKIMI 162 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 +DFGL+++ + G+ + GT GY+AP VL Sbjct: 163 TDFGLSKM----EQNGIMSTACGTPGYVAPEVL 191
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 65.9 bits (159), Expect = 6e-11 Identities = 46/157 (29%), Positives = 82/157 (52%), Gaps = 2/157 (1%) Frame = +1 Query: 1 IAVKRLSKS--STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK L+ S ++ KNE+A++ K +H N++ +G C+ + +V ++ SL Sbjct: 452 VAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLY 510 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + + +E +L+ + YLH + ++HRDLK++N+ L D++ KI Sbjct: 511 KHVHVSETKFKLN--TLIDIGRQVAQGMDYLHAKN---IIHRDLKSNNIFLHEDLSVKIG 565 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAREL 465 DFGLA R + N+ G+ +MAP V+ +EL Sbjct: 566 DFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQEL 602
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 64.3 bits (155), Expect(2) = 8e-11 Identities = 42/147 (28%), Positives = 70/147 (47%), Gaps = 5/147 (3%) Frame = +1 Query: 40 VEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQ---- 207 +++ NEL + ++H N++ L G ++ + LVY+ + SL+ L K + Sbjct: 256 LQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARL-RAHKAQNPLPA 314 Query: 208 LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRG 387 L W + +LH ++H D+K +N+LLD + PKI DFGL R + Sbjct: 315 LTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKS 374 Query: 388 QTQGV-TNRVIGTYGYMAPGVLDAREL 465 V N+V GT Y+ P + R+L Sbjct: 375 LDAVVEVNKVFGTKIYLPPEFRNFRQL 401 Score = 21.2 bits (43), Expect(2) = 8e-11 Identities = 7/11 (63%), Positives = 11/11 (100%) Frame = +3 Query: 480 DVFSFGVMVLE 512 DV+SFG+++LE Sbjct: 406 DVYSFGIVLLE 416
>KCC1G_MOUSE (Q91VB2) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 477 Score = 65.5 bits (158), Expect = 8e-11 Identities = 52/153 (33%), Positives = 80/153 (52%), Gaps = 4/153 (2%) Frame = +1 Query: 4 AVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-DQI 180 A+K + KS L+NE+A++ ++KH+N+V L + LV + V L D+I Sbjct: 50 ALKCIKKSPAFRDSSLENEIAVLKRIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRI 109 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVL-LDADMNPK--I 351 L E+G + ++YLHE+ +VHRDLK N+L L + N K I Sbjct: 110 L---ERGVYTE-KDASLVIQQVLSAVKYLHENG---IVHRDLKPENLLYLTPEENSKIMI 162 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 +DFGL+++ + GV + GT GY+AP VL Sbjct: 163 TDFGLSKM----EQNGVMSTACGTPGYVAPEVL 191
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 65.5 bits (158), Expect = 8e-11 Identities = 42/125 (33%), Positives = 68/125 (54%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK L K T VEE E A++ ++KH NLV+L+GVC + +V E++P +L Sbjct: 314 VAVKTL-KEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 372 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 L + + E++ ++YL + + +HRDL A N L+ + K++DF Sbjct: 373 LRECNR-EEVTAVVLLYMATQISSAMEYLEKKN---FIHRDLAARNCLVGENHVVKVADF 428 Query: 361 GLARL 375 GL+RL Sbjct: 429 GLSRL 433
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 65.5 bits (158), Expect = 8e-11 Identities = 41/150 (27%), Positives = 80/150 (53%), Gaps = 1/150 (0%) Frame = +1 Query: 43 EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXX 222 ++ K+E+AL+++L H N+V+ + C + ++ E++ +L L + ++ L Sbjct: 130 QQFKSEVALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYL-NKKEPYSLSIET 188 Query: 223 XXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQ-G 399 ++YLH V+HRDLK++N+LL+ +M K++DFG + L +TQ Sbjct: 189 VLRLALDISRGMEYLHSQG---VIHRDLKSNNLLLNDEMRVKVADFGTSCL----ETQCR 241 Query: 400 VTNRVIGTYGYMAPGVLDARELLREIGMCS 489 +GTY +MAP ++ + R++ + S Sbjct: 242 EAKGNMGTYRWMAPEMIKEKPYTRKVDVYS 271
>AVR2B_XENLA (P27041) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 511 Score = 65.5 bits (158), Expect = 8e-11 Identities = 49/149 (32%), Positives = 68/149 (45%), Gaps = 13/149 (8%) Frame = +1 Query: 46 ELKNELALVAKLKHKNLVRLV-----GVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQL 210 + + E+ +KH+NL+ + G LE E L+ F SL L KG + Sbjct: 227 QCEKEIFTTPGMKHENLLEFIAAEKRGSNLEM-ELWLITAFHDKGSLTDYL----KGNLV 281 Query: 211 DWXXXXXXXXXXXXXLQYLHED--------SQLKVVHRDLKASNVLLDADMNPKISDFGL 366 W L YLHED + + HRD K+ NVLL D+ ++DFGL Sbjct: 282 SWNELCHITETMARGLAYLHEDVPRCKGEGHKPAIAHRDFKSKNVLLRNDLTAILADFGL 341 Query: 367 ARLFGRGQTQGVTNRVIGTYGYMAPGVLD 453 A F G+ G T+ +GT YMAP VL+ Sbjct: 342 AVRFEPGKPPGDTHGQVGTRRYMAPEVLE 370
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 65.5 bits (158), Expect = 8e-11 Identities = 47/152 (30%), Positives = 78/152 (51%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLSKS--STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K +SK +T+ ++ L+ E + A+LKH +++ ++ + + +V EF Sbjct: 30 VAIKVISKRGRATKELKNLRRECDIQARLKHPHVIEMIESFESKTDLFVVTEFALMDLHR 89 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + ++ GE+ L YLH + +++HRDLK NVLLD +M+ K+ Sbjct: 90 YLSYNGAMGEE----PARRVTGHLVSALYYLHSN---RILHRDLKPQNVLLDKNMHAKLC 142 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR G V + GT YMAP +L Sbjct: 143 DFGLARNMTLG--THVLTSIKGTPLYMAPELL 172
>KCC1G_RAT (Q7TNJ7) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 65.5 bits (158), Expect = 8e-11 Identities = 52/153 (33%), Positives = 80/153 (52%), Gaps = 4/153 (2%) Frame = +1 Query: 4 AVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-DQI 180 A+K + KS L+NE+A++ ++KH+N+V L + LV + V L D+I Sbjct: 50 ALKCIKKSPAFRDSSLENEIAVLKRIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRI 109 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVL-LDADMNPK--I 351 L E+G + ++YLHE+ +VHRDLK N+L L + N K I Sbjct: 110 L---ERGVYTE-KDASLVIQQVLSAVKYLHENG---IVHRDLKPENLLYLTPEENSKIMI 162 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 +DFGL+++ + GV + GT GY+AP VL Sbjct: 163 TDFGLSKM----EQNGVMSTACGTPGYVAPEVL 191
>CHK1_HUMAN (O14757) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 65.5 bits (158), Expect = 8e-11 Identities = 48/159 (30%), Positives = 76/159 (47%), Gaps = 1/159 (0%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +AVK + K + E +K E+ + L H+N+V+ G ++E + Y F+ S + Sbjct: 35 VAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYG---HRREGNIQYLFLEYCSGGE 91 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 + E + + YLH + + HRD+K N+LLD N KISD Sbjct: 92 LFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG---IGITHRDIKPENLLLDERDNLKISD 148 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLRE 474 FGLA +F + + N++ GT Y+AP +L RE E Sbjct: 149 FGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAE 187
>SHK1_SCHPO (P50527) Serine/threonine-protein kinase pak1/shk1 (EC 2.7.11.1)| Length = 658 Score = 65.5 bits (158), Expect = 8e-11 Identities = 41/154 (26%), Positives = 76/154 (49%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+++ + E + NE+ ++ HKN+V + + E +V E++ SL ++ Sbjct: 412 VAIKKMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDTFFYKSELWMVMEYMRGGSLTEV 471 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 + + E LQ+LHE+ +VHRD+K+ N+LL + K++DF Sbjct: 472 VTNNTLSE----GQIAAICKETLEGLQHLHENG---IVHRDIKSDNILLSLQGDIKLTDF 524 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 G T+ T ++GT +MAP V+ +E Sbjct: 525 GFCAQIDSNMTKRTT--MVGTPYWMAPEVVTRKE 556
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 65.1 bits (157), Expect = 1e-10 Identities = 41/125 (32%), Positives = 65/125 (52%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK L K T +++ E A++ ++KH NLV+L+GVC + ++ EF+ + +L Sbjct: 397 VAVKTL-KEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDF 455 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 L + E LD + YL + +HRDL A N L+ + K++DF Sbjct: 456 LRSAGR-ETLDAVALLYMATQIASGMSYLESRN---YIHRDLAARNCLVGDNKLVKVADF 511 Query: 361 GLARL 375 GLARL Sbjct: 512 GLARL 516
>PHO85_ASHGO (Q751E8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 303 Score = 65.1 bits (157), Expect = 1e-10 Identities = 49/154 (31%), Positives = 79/154 (51%), Gaps = 4/154 (2%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPN---RS 168 +A+K + S +G E++L+ +LKH+N+VRL V + + LV+EF+ N + Sbjct: 35 VALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKF 94 Query: 169 LDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPK 348 +D L D E L+ + + HE+ +++HRDLK N+L++ K Sbjct: 95 MDSRL-DREMPRGLELSLVKYFQWQLLQGVAFCHEN---RILHRDLKPQNLLINNKGQLK 150 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 + DFGLAR FG ++ V+ T Y AP VL Sbjct: 151 LGDFGLARAFGI-PVNTFSSEVV-TLWYRAPDVL 182
>CHK1_XENLA (Q6DE87) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (xChk1| protein) Length = 474 Score = 65.1 bits (157), Expect = 1e-10 Identities = 45/140 (32%), Positives = 67/140 (47%), Gaps = 1/140 (0%) Frame = +1 Query: 43 EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-DQILFDTEKGEQLDWX 219 E +K E+ + L H N+VR G E + L E+ L D+I D EQ Sbjct: 50 ENIKKEICINRMLSHTNIVRFYGHRREGNIQYLFLEYCRGGELFDRIEPDVGMPEQ---- 105 Query: 220 XXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQG 399 ++YLH + + HRD+K N+LLD KISDFGLA +F + Sbjct: 106 DAQKFFQQLIAGVEYLHS---IGITHRDIKPENLLLDERDQLKISDFGLATVFRHNGKER 162 Query: 400 VTNRVIGTYGYMAPGVLDAR 459 + N++ GT Y+AP ++ +R Sbjct: 163 LLNKMCGTLPYVAPELIKSR 182
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 65.1 bits (157), Expect = 1e-10 Identities = 44/150 (29%), Positives = 74/150 (49%) Frame = +1 Query: 10 KRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFD 189 K L+KS QG ++ E++ + L+H ++++L V + E ++V EF D I+ Sbjct: 86 KTLAKSDMQG--RVEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEFAGKELFDYIV-- 141 Query: 190 TEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLA 369 ++G+ + ++Y H K+VHRDLK N+LLD +N KI+DFGL+ Sbjct: 142 -QRGKMPE-DEARRFFQQIIAAVEYCHRH---KIVHRDLKPENLLLDDQLNVKIADFGLS 196 Query: 370 RLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 + G G+ Y AP V+ + Sbjct: 197 NIMTDG---NFLKTSCGSPNYAAPEVISGK 223
>CDC2_CARAU (P51958) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 302 Score = 64.7 bits (156), Expect = 1e-10 Identities = 49/152 (32%), Positives = 83/152 (54%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ +S +GV E++L+ +L+H N+VRL+ V +++ + LV+EF+ + L Sbjct: 30 VAMKKIRLESEEEGVPSTAVREISLLKELQHPNVVRLLDVLMQESKLYLVFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ +D + + H +V+HRDLK N+L+D K++ Sbjct: 89 KYLDSIPSGQFMDPMLVKSYLYQILEGILFCH---CRRVLHRDLKPQNLLIDNKGVIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y AP VL Sbjct: 146 DFGLARAFG-VPVRVYTHEVV-TLWYRAPEVL 175
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 64.7 bits (156), Expect = 1e-10 Identities = 45/153 (29%), Positives = 74/153 (48%), Gaps = 5/153 (3%) Frame = +1 Query: 40 VEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWX 219 V++ K E A L H N+V + V E +V E+V R+L +++ E G L+ Sbjct: 52 VKKFKRESQAAASLSHPNIVGIYDVGQEGDIYYIVMEYVKGRTLKELI--RENGGPLEVK 109 Query: 220 XXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQG 399 L + H++ K++HRD+K N+L+ + K++DFG+AR G T Sbjct: 110 RAVEIASQVCRALDHAHKN---KIIHRDIKPQNILVTDEDVVKVTDFGIARA-ANGATIT 165 Query: 400 VTNRVIGTYGYMAP-----GVLDARELLREIGM 483 T VIGT Y +P ++D R + +G+ Sbjct: 166 YTGDVIGTAYYFSPEQAKGSIVDERTDIYSLGI 198
>PHO85_YEAST (P17157) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 305 Score = 64.3 bits (155), Expect = 2e-10 Identities = 50/155 (32%), Positives = 83/155 (53%), Gaps = 5/155 (3%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPN---RS 168 +A+K + S +G E++L+ +LKH+N+VRL V + + LV+EF+ N + Sbjct: 33 VALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKY 92 Query: 169 LD-QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNP 345 +D + + +T +G +L+ L + HE+ K++HRDLK N+L++ Sbjct: 93 MDSRTVGNTPRGLELN--LVKYFQWQLLQGLAFCHEN---KILHRDLKPQNLLINKRGQL 147 Query: 346 KISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 K+ DFGLAR FG ++ V+ T Y AP VL Sbjct: 148 KLGDFGLARAFGI-PVNTFSSEVV-TLWYRAPDVL 180
>CHK1_CHICK (Q8AYC9) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 64.3 bits (155), Expect = 2e-10 Identities = 51/160 (31%), Positives = 74/160 (46%), Gaps = 2/160 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-D 174 +AVK + K + E +K E+ + L H+N+V+ G E + L E+ L D Sbjct: 35 VAVKIVDMKRAADCPENIKKEICINKMLNHENVVKFYGHRREGATQYLFLEYCSGGELFD 94 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 +I D E + YLH + + HRDLK N+LLD N KIS Sbjct: 95 RIEPDIGMPEP----EAQRFFQQLIAGVVYLHS---MGITHRDLKPENLLLDERDNLKIS 147 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLRE 474 DFGLA +F + + N++ GT Y+AP +L E E Sbjct: 148 DFGLATVFKHNGRERLLNKMCGTLPYVAPELLRRPEFRAE 187
>CC2H1_TRYBB (P38973) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 64.3 bits (155), Expect = 2e-10 Identities = 47/152 (30%), Positives = 79/152 (51%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVKR+ + +GV E++++ +L+H+N+VRL+ VC ++ LV+E + +D Sbjct: 31 VAVKRIRLEKEEEGVPCTAIREISILKELRHENIVRLLDVCHSEKRLTLVFECM---EMD 87 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + G LD +++ HE + V+HRDLK N+L+ + K++ Sbjct: 88 LKKYMDHVGGDLDAGTIQEFMRSLLSGVRFCHERN---VLHRDLKPPNLLISREKELKLA 144 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGL R FG + T V+ T Y +P VL Sbjct: 145 DFGLGRAFGI-PVKKFTQEVV-TLWYRSPDVL 174
>M3K5_MOUSE (O35099) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1380 Score = 63.9 bits (154), Expect = 2e-10 Identities = 50/153 (32%), Positives = 75/153 (49%), Gaps = 2/153 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 IA+K + + ++ + L E+AL LKHKN+V+ +G E + E VP SL + Sbjct: 713 IAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSAL 772 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNP-KISD 357 L + + L+YLH++ ++VHRD+K NVL++ KISD Sbjct: 773 LRSKWGPLKDNEQTIGFYTKQILEGLKYLHDN---QIVHRDIKGDNVLINTYSGVLKISD 829 Query: 358 FGLA-RLFGRGQTQGVTNRVIGTYGYMAPGVLD 453 FG + RL G T GT YMAP ++D Sbjct: 830 FGTSKRLAG---INPCTETFTGTLQYMAPEIID 859
>M3K6_HUMAN (O95382) Mitogen-activated protein kinase kinase kinase 6 (EC| 2.7.11.25) Length = 1011 Score = 63.9 bits (154), Expect = 2e-10 Identities = 49/153 (32%), Positives = 74/153 (48%), Gaps = 2/153 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 IA+K + + ++ + L E+AL +L+HKN+VR +G + + E VP SL + Sbjct: 397 IAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSL 456 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMN-PKISD 357 L + + L YLH++ +VHRD+K NVL++ KISD Sbjct: 457 LRSVWGPLKDNESTISFYTRQILQGLGYLHDN---HIVHRDIKGDNVLINTFSGLLKISD 513 Query: 358 FGLA-RLFGRGQTQGVTNRVIGTYGYMAPGVLD 453 FG + RL G T GT YMAP ++D Sbjct: 514 FGTSKRLAG---ITPCTETFTGTLQYMAPEIID 543
>M3K5_HUMAN (Q99683) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1374 Score = 63.9 bits (154), Expect = 2e-10 Identities = 50/153 (32%), Positives = 75/153 (49%), Gaps = 2/153 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 IA+K + + ++ + L E+AL LKHKN+V+ +G E + E VP SL + Sbjct: 706 IAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSAL 765 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNP-KISD 357 L + + L+YLH++ ++VHRD+K NVL++ KISD Sbjct: 766 LRSKWGPLKDNEQTIGFYTKQILEGLKYLHDN---QIVHRDIKGDNVLINTYSGVLKISD 822 Query: 358 FGLA-RLFGRGQTQGVTNRVIGTYGYMAPGVLD 453 FG + RL G T GT YMAP ++D Sbjct: 823 FGTSKRLAG---INPCTETFTGTLQYMAPEIID 852
>PLO1_SCHPO (P50528) Serine/threonine-protein kinase plo1 (EC 2.7.11.21)| Length = 683 Score = 63.9 bits (154), Expect = 2e-10 Identities = 46/152 (30%), Positives = 75/152 (49%), Gaps = 3/152 (1%) Frame = +1 Query: 4 AVKRLSKSSTQGVE---ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 A K ++K S Q + +L E+ + + H N+V + + L+ E ++SL Sbjct: 67 AAKVIAKRSLQNDKTKLKLFGEIKVHQSMSHPNIVGFIDCFEDSTNIYLILELCEHKSLM 126 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 ++L K +QL L+Y+H+ +V+HRDLK N++LD N KI Sbjct: 127 ELL---RKRKQLTEPEVRYLMMQILGALKYMHKK---RVIHRDLKLGNIMLDESNNVKIG 180 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLA L + + +T + GT Y+AP +L Sbjct: 181 DFGLAALLMDDEERKMT--ICGTPNYIAPEIL 210 Score = 29.3 bits (64), Expect = 6.6 Identities = 30/141 (21%), Positives = 58/141 (41%), Gaps = 9/141 (6%) Frame = +1 Query: 103 LVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLD---WXXXXXXXXXXXXXLQYLHE 273 L + ++ +ER + PN +ILF++++G + W + + Sbjct: 184 LAALLMDDEERKMTICGTPNYIAPEILFNSKEGHSFEVDLWSAGVVMYALLIGKPPF--Q 241 Query: 274 DSQLKVVHRDLKA------SNVLLDADMNPKISDFGLARLFGRGQTQGVTNRVIGTYGYM 435 D ++K ++R +KA SNV + A+ IS R + + GYM Sbjct: 242 DKEVKTIYRKIKANSYSFPSNVDISAEAKDLISSLLTHDPSIRPSIDDIVDHEFFHTGYM 301 Query: 436 APGVLDARELLREIGMCSASE 498 A + D E+L + + +S+ Sbjct: 302 ASTLPD--EILHSMPIWPSSQ 320
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 63.9 bits (154), Expect = 2e-10 Identities = 40/125 (32%), Positives = 68/125 (54%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK L K T VEE E A++ ++KH NLV+L+GVC + ++ EF+ +L Sbjct: 268 VAVKTL-KEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 326 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 L + + ++++ ++YL + + +HRDL A N L+ + K++DF Sbjct: 327 LRECNR-QEVNAVVLLYMATQISSAMEYLEKKN---FIHRDLAARNCLVGENHLVKVADF 382 Query: 361 GLARL 375 GL+RL Sbjct: 383 GLSRL 387
>PHO85_KLULA (Q92241) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 304 Score = 63.9 bits (154), Expect = 2e-10 Identities = 48/154 (31%), Positives = 78/154 (50%), Gaps = 4/154 (2%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K + S +G E++L+ +LKH N+VRL V + + LV+EF+ N L + Sbjct: 33 VALKEVKLDSEEGTPSTAIREISLMKELKHDNIVRLFDVIHTENKLTLVFEFMDN-DLKK 91 Query: 178 ILFDTEKGEQ---LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPK 348 + + KG L+ + + HE+ +++HRDLK N+L++ K Sbjct: 92 FMDNRNKGNSHKGLEMDLVKYFQWQLLQGVAFCHEN---RILHRDLKPQNLLINNRGQLK 148 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 + DFGLAR FG ++ V+ T Y AP VL Sbjct: 149 LGDFGLARAFGI-PVNTFSSEVV-TLWYRAPDVL 180
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 63.9 bits (154), Expect = 2e-10 Identities = 40/125 (32%), Positives = 68/125 (54%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK L K T VEE E A++ ++KH NLV+L+GVC + ++ EF+ +L Sbjct: 217 VAVKTL-KEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 275 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 L + + ++++ ++YL + + +HRDL A N L+ + K++DF Sbjct: 276 LRECNR-QEVNAVVLLYMATQISSAMEYLEKKN---FIHRDLAARNCLVGENHLVKVADF 331 Query: 361 GLARL 375 GL+RL Sbjct: 332 GLSRL 336
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 63.9 bits (154), Expect = 2e-10 Identities = 49/163 (30%), Positives = 79/163 (48%), Gaps = 13/163 (7%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKL----KHKNLVRLVGVCLEQQERLLVYEFVPNRS 168 +A+K ++ ++ +++ + AKL KH+N+ L GVCL + LV E+ S Sbjct: 166 VAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTK-LCLVMEYARGGS 224 Query: 169 LDQILFDTEKGEQL-DWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNP 345 L++IL + L +W + YLH ++ + ++HRDLK+SNVL+ + Sbjct: 225 LNRILAGKIPPDVLVNWAIQIARG------MNYLHNEAPMSIIHRDLKSSNVLIYEAIEG 278 Query: 346 --------KISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 KI+DFGLAR Q GTY +M P V+ Sbjct: 279 NHLQQKTLKITDFGLAREMYNTQRMSAA----GTYAWMPPEVI 317
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 63.5 bits (153), Expect = 3e-10 Identities = 50/157 (31%), Positives = 81/157 (51%), Gaps = 4/157 (2%) Frame = +1 Query: 1 IAVKRLSKSS---TQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +A+K ++KS+ + V+++K E++++ ++H N+VRL V + +V EFV L Sbjct: 37 VAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGEL 96 Query: 172 -DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPK 348 D+I+ KG +L+ + + H V HRDLK N+LLD + N K Sbjct: 97 FDRIV---HKG-RLEESESRKYFQQLVDAVAHCHCKG---VYHRDLKPENLLLDTNGNLK 149 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 +SDFGL+ L G + GT Y+AP VL + Sbjct: 150 VSDFGLSALPQEGVE--LLRTTCGTPNYVAPEVLSGQ 184
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 63.5 bits (153), Expect = 3e-10 Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 3/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE---ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +AVK L++ + ++ ++K E+ + +H ++++L V + +V E+V L Sbjct: 42 VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGEL 101 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + + E+++ + Y H VVHRDLK NVLLDA MN KI Sbjct: 102 FDYICKHGRVEEME---ARRLFQQILSAVDYCHRHM---VVHRDLKPENVLLDAQMNAKI 155 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 +DFGL+ + G+ G+ Y AP V+ R Sbjct: 156 ADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 188
>OXSR1_PONPY (Q5R495) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 63.5 bits (153), Expect = 3e-10 Identities = 48/160 (30%), Positives = 78/160 (48%), Gaps = 9/160 (5%) Frame = +1 Query: 1 IAVKRLSKSSTQ-GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS-LD 174 +A+KR++ Q ++EL E+ +++ H N+V + + E LV + + S LD Sbjct: 43 VAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLD 102 Query: 175 QILFDTEKGEQ----LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMN 342 I KGE LD L+YLH++ Q +HRD+KA N+LL D + Sbjct: 103 IIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQ---IHRDVKAGNILLGEDGS 159 Query: 343 PKISDFGLARLFGRG---QTQGVTNRVIGTYGYMAPGVLD 453 +I+DFG++ G V +GT +MAP V++ Sbjct: 160 VQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVME 199
>OXSR1_HUMAN (O95747) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 63.5 bits (153), Expect = 3e-10 Identities = 48/160 (30%), Positives = 78/160 (48%), Gaps = 9/160 (5%) Frame = +1 Query: 1 IAVKRLSKSSTQ-GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS-LD 174 +A+KR++ Q ++EL E+ +++ H N+V + + E LV + + S LD Sbjct: 43 VAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLD 102 Query: 175 QILFDTEKGEQ----LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMN 342 I KGE LD L+YLH++ Q +HRD+KA N+LL D + Sbjct: 103 IIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQ---IHRDVKAGNILLGEDGS 159 Query: 343 PKISDFGLARLFGRG---QTQGVTNRVIGTYGYMAPGVLD 453 +I+DFG++ G V +GT +MAP V++ Sbjct: 160 VQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVME 199
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 63.5 bits (153), Expect = 3e-10 Identities = 45/157 (28%), Positives = 75/157 (47%), Gaps = 4/157 (2%) Frame = +1 Query: 1 IAVKRLSK----SSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS 168 +AVK L+K ++ +K E++++ +L H N+V+L V + + EFV Sbjct: 47 VAVKILNKKKLLTNPALANNIKREISIMRRLSHPNIVKLHEVMATKSKIFFAMEFVKGGE 106 Query: 169 LDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPK 348 L + K +L + Y H V HRDLK N+L+D + N K Sbjct: 107 LFNKI---SKHGRLSEDLSRRYFQQLISAVGYCHARG---VYHRDLKPENLLIDENGNLK 160 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 +SDFGL+ L + + G+ + + GT Y+AP +L + Sbjct: 161 VSDFGLSALTDQIRPDGLLHTLCGTPAYVAPEILSKK 197
>OXSR1_PIG (Q863I2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 529 Score = 63.5 bits (153), Expect = 3e-10 Identities = 48/160 (30%), Positives = 78/160 (48%), Gaps = 9/160 (5%) Frame = +1 Query: 1 IAVKRLSKSSTQ-GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS-LD 174 +A+KR++ Q ++EL E+ +++ H N+V + + E LV + + S LD Sbjct: 43 VAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLD 102 Query: 175 QILFDTEKGEQ----LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMN 342 I KGE LD L+YLH++ Q +HRD+KA N+LL D + Sbjct: 103 IIKHIVAKGEHKSGVLDEATIATILREVLEGLEYLHKNGQ---IHRDVKAGNILLGEDGS 159 Query: 343 PKISDFGLARLFGRG---QTQGVTNRVIGTYGYMAPGVLD 453 +I+DFG++ G V +GT +MAP V++ Sbjct: 160 VQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVME 199
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 63.5 bits (153), Expect = 3e-10 Identities = 47/169 (27%), Positives = 80/169 (47%), Gaps = 1/169 (0%) Frame = +1 Query: 1 IAVKRLSKSST-QGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L T + E +E +++ + +H N++ L GV + + ++V EF+ N SLD Sbjct: 666 VAIKTLKSGYTDEQRREFLSEASIMGQFEHPNVIHLEGVVTKSRPVMIVTEFMENGSLDS 725 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L +K Q ++YL S + VHRDL A N+L+++++ K+SD Sbjct: 726 FL--RQKEGQFSVLQLVGMLRGIAAGMRYL---SDMNYVHRDLAARNILVNSNLVCKVSD 780 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLREIGMCSASE*W 504 FGL+R + G G P A E ++ S+S+ W Sbjct: 781 FGLSRFL---EDDASNPTYTGALGCKIPIRWTAPEAVQYRKFTSSSDVW 826
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 63.5 bits (153), Expect = 3e-10 Identities = 45/156 (28%), Positives = 73/156 (46%), Gaps = 3/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE---ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +AVK L++ + ++ +++ E+ + +H ++++L V + +V E+V L Sbjct: 42 VAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGEL 101 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + K +LD + Y H VVHRDLK NVLLDA MN KI Sbjct: 102 FDYIC---KNGRLDEKESRRLFQQILSGVDYCHRHM---VVHRDLKPENVLLDAHMNAKI 155 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 +DFGL+ + G+ G+ Y AP V+ R Sbjct: 156 ADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 188
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 63.5 bits (153), Expect = 3e-10 Identities = 45/156 (28%), Positives = 73/156 (46%), Gaps = 3/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE---ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +AVK L++ + ++ +++ E+ + +H ++++L V + +V E+V L Sbjct: 42 VAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGEL 101 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + K +LD + Y H VVHRDLK NVLLDA MN KI Sbjct: 102 FDYIC---KNGRLDEKESRRLFQQILSGVDYCHRHM---VVHRDLKPENVLLDAHMNAKI 155 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 +DFGL+ + G+ G+ Y AP V+ R Sbjct: 156 ADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 188
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 63.5 bits (153), Expect = 3e-10 Identities = 40/125 (32%), Positives = 67/125 (53%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK L K T VEE E A++ ++KH NLV+L+GVC + ++ EF+ +L Sbjct: 268 VAVKTL-KEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 326 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 L + + +++ ++YL + + +HRDL A N L+ + K++DF Sbjct: 327 LRECNR-QEVSAVVLLYMATQISSAMEYLEKKN---FIHRDLAARNCLVGENHLVKVADF 382 Query: 361 GLARL 375 GL+RL Sbjct: 383 GLSRL 387
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 63.5 bits (153), Expect = 3e-10 Identities = 40/125 (32%), Positives = 67/125 (53%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK L K T VEE E A++ ++KH NLV+L+GVC + ++ EF+ +L Sbjct: 154 VAVKTL-KEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 212 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 L + + +++ ++YL + + +HRDL A N L+ + K++DF Sbjct: 213 LRECNR-QEVSAVVLLYMATQISSAMEYLEKKN---FIHRDLAARNCLVGENHLVKVADF 268 Query: 361 GLARL 375 GL+RL Sbjct: 269 GLSRL 273
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 63.5 bits (153), Expect = 3e-10 Identities = 45/156 (28%), Positives = 73/156 (46%), Gaps = 3/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE---ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +AVK L++ + ++ +++ E+ + +H ++++L V + +V E+V L Sbjct: 44 VAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGEL 103 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + K +LD + Y H VVHRDLK NVLLDA MN KI Sbjct: 104 FDYIC---KNGRLDEKESRRLFQQILSGVDYCHRHM---VVHRDLKPENVLLDAHMNAKI 157 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 +DFGL+ + G+ G+ Y AP V+ R Sbjct: 158 ADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 190
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 63.5 bits (153), Expect = 3e-10 Identities = 45/156 (28%), Positives = 73/156 (46%), Gaps = 3/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE---ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +AVK L++ + ++ +++ E+ + +H ++++L V + +V E+V L Sbjct: 44 VAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGEL 103 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + K +LD + Y H VVHRDLK NVLLDA MN KI Sbjct: 104 FDYIC---KNGRLDEKESRRLFQQILSGVDYCHRHM---VVHRDLKPENVLLDAHMNAKI 157 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 +DFGL+ + G+ G+ Y AP V+ R Sbjct: 158 ADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 190
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 63.5 bits (153), Expect = 3e-10 Identities = 48/152 (31%), Positives = 81/152 (53%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ + T+GV E++L+ +L H N+V+L+ V + + LV+EF+ N+ L Sbjct: 30 VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFL-NQDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + + G + LQ L +V+HRDLK N+L+++D K++ Sbjct: 89 KFM----DGSNISGISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSDGAIKLA 144 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y AP +L Sbjct: 145 DFGLARAFG-VPVRTFTHEVV-TLWYRAPEIL 174
>AVR2A_SHEEP (Q28560) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 63.2 bits (152), Expect = 4e-10 Identities = 43/136 (31%), Positives = 64/136 (47%), Gaps = 11/136 (8%) Frame = +1 Query: 79 LKHKNLVRLVGV----CLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXXXXX 246 +KH+N+++ +G + L+ F SL L K + W Sbjct: 241 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL----KANVVSWNELCHIAETM 296 Query: 247 XXXLQYLHED-------SQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVT 405 L YLHED + + HRD+K+ NVLL ++ I+DFGLA F G++ G T Sbjct: 297 ARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDT 356 Query: 406 NRVIGTYGYMAPGVLD 453 + +GT YMAP VL+ Sbjct: 357 HGQVGTRRYMAPEVLE 372
>AVR2A_MOUSE (P27038) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 63.2 bits (152), Expect = 4e-10 Identities = 43/136 (31%), Positives = 64/136 (47%), Gaps = 11/136 (8%) Frame = +1 Query: 79 LKHKNLVRLVGV----CLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXXXXX 246 +KH+N+++ +G + L+ F SL L K + W Sbjct: 241 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL----KANVVSWNELCHIAETM 296 Query: 247 XXXLQYLHED-------SQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVT 405 L YLHED + + HRD+K+ NVLL ++ I+DFGLA F G++ G T Sbjct: 297 ARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDT 356 Query: 406 NRVIGTYGYMAPGVLD 453 + +GT YMAP VL+ Sbjct: 357 HGQVGTRRYMAPEVLE 372
>AVR2A_HUMAN (P27037) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) (ACTRIIA) Length = 513 Score = 63.2 bits (152), Expect = 4e-10 Identities = 43/136 (31%), Positives = 64/136 (47%), Gaps = 11/136 (8%) Frame = +1 Query: 79 LKHKNLVRLVGV----CLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXXXXX 246 +KH+N+++ +G + L+ F SL L K + W Sbjct: 241 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL----KANVVSWNELCHIAETM 296 Query: 247 XXXLQYLHED-------SQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVT 405 L YLHED + + HRD+K+ NVLL ++ I+DFGLA F G++ G T Sbjct: 297 ARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDT 356 Query: 406 NRVIGTYGYMAPGVLD 453 + +GT YMAP VL+ Sbjct: 357 HGQVGTRRYMAPEVLE 372
>AVR2A_BOVIN (Q28043) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 63.2 bits (152), Expect = 4e-10 Identities = 43/136 (31%), Positives = 64/136 (47%), Gaps = 11/136 (8%) Frame = +1 Query: 79 LKHKNLVRLVGV----CLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXXXXX 246 +KH+N+++ +G + L+ F SL L K + W Sbjct: 241 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL----KANVVSWNELCHIAETM 296 Query: 247 XXXLQYLHED-------SQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVT 405 L YLHED + + HRD+K+ NVLL ++ I+DFGLA F G++ G T Sbjct: 297 ARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDT 356 Query: 406 NRVIGTYGYMAPGVLD 453 + +GT YMAP VL+ Sbjct: 357 HGQVGTRRYMAPEVLE 372
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 63.2 bits (152), Expect = 4e-10 Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 3/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE---ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +AVK L++ + ++ ++K E+ + +H ++++L V + +V E+V L Sbjct: 42 VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGEL 101 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + + E+++ + Y H VVHRDLK NVLLDA MN KI Sbjct: 102 FDYICKHGRVEEVE---ARRLFQQILSAVDYCHRHM---VVHRDLKPENVLLDAQMNAKI 155 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 +DFGL+ + G+ G+ Y AP V+ R Sbjct: 156 ADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 188
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 63.2 bits (152), Expect = 4e-10 Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 3/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE---ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +AVK L++ + ++ ++K E+ + +H ++++L V + +V E+V L Sbjct: 42 VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGEL 101 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + + E+++ + Y H VVHRDLK NVLLDA MN KI Sbjct: 102 FDYICKHGRVEEME---ARRLFQQILSAVDYCHRHM---VVHRDLKPENVLLDAHMNAKI 155 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 +DFGL+ + G+ G+ Y AP V+ R Sbjct: 156 ADFGLSNIMSDGE---FLRTSCGSPNYAAPEVISGR 188
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 63.2 bits (152), Expect = 4e-10 Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 3/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE---ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +AVK L++ + ++ ++K E+ + +H ++++L V + +V E+V L Sbjct: 42 VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGEL 101 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + + E+++ + Y H VVHRDLK NVLLDA MN KI Sbjct: 102 FDYICKHGRVEEME---ARRLFQQILSAVDYCHRHM---VVHRDLKPENVLLDAHMNAKI 155 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 +DFGL+ + G+ G+ Y AP V+ R Sbjct: 156 ADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGR 188
>CDC21_XENLA (P35567) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 1) Length = 302 Score = 63.2 bits (152), Expect = 4e-10 Identities = 46/152 (30%), Positives = 81/152 (53%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ ++ +GV E++L+ +L+H N+V L+ V ++ L++EF+ + L Sbjct: 30 VAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDVLMQDSRLYLIFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ +D + + H +V+HRDLK N+L+D+ K++ Sbjct: 89 KYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSR---RVLHRDLKPQNLLIDSKGVIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y AP VL Sbjct: 146 DFGLARAFGI-PVRVYTHEVV-TLWYRAPEVL 175
>DCAK1_MOUSE (Q9JLM8) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 756 Score = 63.2 bits (152), Expect = 4e-10 Identities = 47/154 (30%), Positives = 74/154 (48%), Gaps = 5/154 (3%) Frame = +1 Query: 4 AVKRLSKSSTQGVEEL-KNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 A+K + KS +G E + +NE++++ ++KH N+V L+ E LV E V L Sbjct: 433 ALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDA 492 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL----DADMNPK 348 + T K + D ++YLH L +VHRD+K N+L+ D + K Sbjct: 493 ITSTSKYTERD---ASGMLYNLASAIKYLH---SLNIVHRDIKPENLLVYEHQDGSKSLK 546 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 + DFGLA + G V GT Y+AP ++ Sbjct: 547 LGDFGLATI-----VDGPLYTVCGTPTYVAPEII 575
>DCAK1_HUMAN (O15075) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 740 Score = 63.2 bits (152), Expect = 4e-10 Identities = 47/154 (30%), Positives = 74/154 (48%), Gaps = 5/154 (3%) Frame = +1 Query: 4 AVKRLSKSSTQGVEEL-KNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 A+K + KS +G E + +NE++++ ++KH N+V L+ E LV E V L Sbjct: 417 ALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDA 476 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL----DADMNPK 348 + T K + D ++YLH L +VHRD+K N+L+ D + K Sbjct: 477 ITSTNKYTERD---ASGMLYNLASAIKYLH---SLNIVHRDIKPENLLVYEHQDGSKSLK 530 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 + DFGLA + G V GT Y+AP ++ Sbjct: 531 LGDFGLATI-----VDGPLYTVCGTPTYVAPEII 559
>DCAK1_RAT (O08875) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) Length = 433 Score = 63.2 bits (152), Expect = 4e-10 Identities = 47/154 (30%), Positives = 74/154 (48%), Gaps = 5/154 (3%) Frame = +1 Query: 4 AVKRLSKSSTQGVEEL-KNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 A+K + KS +G E + +NE++++ ++KH N+V L+ E LV E V L Sbjct: 110 ALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDA 169 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL----DADMNPK 348 + T K + D ++YLH L +VHRD+K N+L+ D + K Sbjct: 170 ITSTSKYTERD---ASGMLYNLASAIKYLH---SLNIVHRDIKPENLLVYEHQDGSKSLK 223 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 + DFGLA + G V GT Y+AP ++ Sbjct: 224 LGDFGLATI-----VDGPLYTVCGTPTYVAPEII 252
>PR2_DROME (Q9I7F7) Tyrosine-protein kinase PR2 (EC 2.7.10.2)| Length = 1337 Score = 62.8 bits (151), Expect = 5e-10 Identities = 50/169 (29%), Positives = 79/169 (46%), Gaps = 1/169 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L + Q E E A++ ++H+N+VRL GV L +LV E RSL + Sbjct: 161 VAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLE 220 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L D+ G ++ + + Q +++HRDL A N+L+ + KISD Sbjct: 221 CLKDS--GLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISD 278 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLREIGMCSASE*W 504 FGL+R G G+ TN + P A E + + +AS+ W Sbjct: 279 FGLSRALGVGKDYYKTNFNV---NLKLPIAWCAPECINYLRFTNASDVW 324
>CC2H1_TRYCO (P54664) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 62.8 bits (151), Expect = 5e-10 Identities = 46/152 (30%), Positives = 79/152 (51%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQ-GVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+KR+ S + GV E++++ +L+H+N+VRL+ VC + LV+E++ +D Sbjct: 31 VALKRIRLESVEEGVPCTAIREISILKELRHENIVRLLDVCHSENRLNLVFEYM---EMD 87 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + LD +++ HE + V+HRDLK N+L+ + K++ Sbjct: 88 LKKYMDRASGNLDPATIQEFMRSLLKGVRFCHERN---VLHRDLKPPNLLISREKELKLA 144 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGL R FG + T+ V+ T Y +P VL Sbjct: 145 DFGLGRAFGI-PVKKYTHEVV-TLWYRSPDVL 174
>OXSR1_MOUSE (Q6P9R2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 62.8 bits (151), Expect = 5e-10 Identities = 48/160 (30%), Positives = 78/160 (48%), Gaps = 9/160 (5%) Frame = +1 Query: 1 IAVKRLSKSSTQ-GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS-LD 174 +A+KR++ Q ++EL E+ +++ H N+V + + E LV + + S LD Sbjct: 43 VAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLD 102 Query: 175 QILFDTEKGEQ----LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMN 342 I KGE LD L+YLH++ Q +HRD+KA N+LL D + Sbjct: 103 IIKHIVAKGEHKSGVLDEPTIATILREVLEGLEYLHKNGQ---IHRDVKAGNILLGEDGS 159 Query: 343 PKISDFGLARLFGRG---QTQGVTNRVIGTYGYMAPGVLD 453 +I+DFG++ G V +GT +MAP V++ Sbjct: 160 VQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVME 199
>MARK2_HUMAN (Q7KZI7) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog) Length = 788 Score = 62.8 bits (151), Expect = 5e-10 Identities = 46/156 (29%), Positives = 77/156 (49%), Gaps = 2/156 (1%) Frame = +1 Query: 1 IAVKRLSKS--STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK + K+ ++ +++L E+ ++ L H N+V+L V ++ LV E+ + Sbjct: 79 VAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVF 138 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + ++ + +QY H Q +VHRDLKA N+LLDADMN KI+ Sbjct: 139 DYLVAHGRMKEKE---ARAKFRQIVSAVQYCH---QKFIVHRDLKAENLLLDADMNIKIA 192 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 DFG + F G + G+ Y AP + ++ Sbjct: 193 DFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGKK 225
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 62.8 bits (151), Expect = 5e-10 Identities = 45/151 (29%), Positives = 75/151 (49%), Gaps = 1/151 (0%) Frame = +1 Query: 10 KRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFD 189 K L+KS QG ++ E++ + L+H ++++L V + E ++V EF D I+ Sbjct: 87 KTLAKSDMQG--RVEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEFAGKELFDYIV-- 142 Query: 190 TEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLA 369 ++G+ + ++Y H K+VHRDLK N+LLD +N KI+DFGL+ Sbjct: 143 -QRGKMPE-DEARRFFQQIIAAVEYCHRH---KIVHRDLKPENLLLDDQLNVKIADFGLS 197 Query: 370 RLFGRGQTQGVTNRVIGTYGYM-APGVLDAR 459 + G G+ YM AP V+ + Sbjct: 198 NIMTDG---NFLKTSCGSPNYMPAPEVISGK 225
>MARK2_MOUSE (Q05512) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 776 Score = 62.8 bits (151), Expect = 5e-10 Identities = 46/157 (29%), Positives = 78/157 (49%), Gaps = 2/157 (1%) Frame = +1 Query: 1 IAVKRLSKS--STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK + K+ ++ +++L E+ ++ L H N+V+L V ++ LV E+ + Sbjct: 79 VAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVF 138 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + ++ + +QY H Q +VHRDLKA N+LLDADMN KI+ Sbjct: 139 DYLVAHGRMKEKE---ARAKFRQIVLHVQYCH---QKFIVHRDLKAENLLLDADMNIKIA 192 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAREL 465 DFG + F G + G+ Y AP + +++ Sbjct: 193 DFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGKKI 226
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 62.8 bits (151), Expect = 5e-10 Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 3/153 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K + SS + L E+ L+ +L H N++R +GVC+ Q + + E++ + +L+Q+ Sbjct: 84 MALKMNTLSSNRA--NLLKEMQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQL 141 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMN---PKI 351 L + L W L YLH + HRDL + N L+ D N + Sbjct: 142 L---DSNLYLPWTVRVKLAYDIAVGLSYLHFKG---IFHRDLTSKNCLIKRDENGYSAVV 195 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 +DFGLA V+G+ +MAP VL Sbjct: 196 ADFGLAEKIPDASIGSEKLAVVGSPFWMAPEVL 228
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 62.8 bits (151), Expect = 5e-10 Identities = 45/164 (27%), Positives = 84/164 (51%), Gaps = 1/164 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLV-GVCLEQQERLLVYEFVPNRSLDQ 177 IA+K++ + E + NE+ ++ +HKN+V + + E ++ E++ SL + Sbjct: 707 IAIKQMDLDAQPRKELIINEILVMKDSQHKNIVNFLDSYLIGDNELWVIMEYMQGGSLTE 766 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 I+ + + +L+ LQ+LH+ ++HRD+K+ NVLLDA N KI+D Sbjct: 767 IIENNDF--KLNEKQIATICFETLKGLQHLHKKH---IIHRDIKSDNVLLDAYGNVKITD 821 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLREIGMCS 489 FG + + T ++GT +MAP V+ +E ++ + S Sbjct: 822 FGFCAKLTDQRNKRAT--MVGTPYWMAPEVVKQKEYDEKVDVWS 863
>MARK2_RAT (O08679) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 722 Score = 62.8 bits (151), Expect = 5e-10 Identities = 46/156 (29%), Positives = 77/156 (49%), Gaps = 2/156 (1%) Frame = +1 Query: 1 IAVKRLSKS--STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK + K+ ++ +++L E+ ++ L H N+V+L V ++ LV E+ + Sbjct: 79 VAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVF 138 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + ++ + +QY H Q +VHRDLKA N+LLDADMN KI+ Sbjct: 139 DYLVAHGRMKEKE---ARAKFRQIVSAVQYCH---QKFIVHRDLKAENLLLDADMNIKIA 192 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 DFG + F G + G+ Y AP + ++ Sbjct: 193 DFGFSNEFTFGNK---LDTFCGSPPYAAPELFQGKK 225
>AVR2A_RAT (P38444) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 62.8 bits (151), Expect = 5e-10 Identities = 43/136 (31%), Positives = 64/136 (47%), Gaps = 11/136 (8%) Frame = +1 Query: 79 LKHKNLVRLVGV----CLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXXXXX 246 +KH+N+++ +G + L+ F SL L K + W Sbjct: 241 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL----KANVVSWNELCHIAETM 296 Query: 247 XXXLQYLHED-------SQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVT 405 L YLHED + + HRD+K+ NVLL ++ I+DFGLA F G++ G T Sbjct: 297 ARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSGGDT 356 Query: 406 NRVIGTYGYMAPGVLD 453 + +GT YMAP VL+ Sbjct: 357 HGQVGTRRYMAPEVLE 372
>CDC2_HUMAN (P06493) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 62.4 bits (150), Expect = 7e-10 Identities = 46/152 (30%), Positives = 79/152 (51%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ +S +GV E++L+ +L+H N+V L V ++ L++EF+ + L Sbjct: 30 VAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ +D + + H +V+HRDLK N+L+D K++ Sbjct: 89 KYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR---RVLHRDLKPQNLLIDDKGTIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y +P VL Sbjct: 146 DFGLARAFGI-PIRVYTHEVV-TLWYRSPEVL 175
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 62.4 bits (150), Expect = 7e-10 Identities = 45/151 (29%), Positives = 79/151 (52%), Gaps = 1/151 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K ++ S +G E++L+ +LKH+N+V L V + + LV+E++ ++ L + Sbjct: 33 VALKEINLDSEEGTPSTAIREISLMKELKHENIVTLYDVIHTENKLNLVFEYM-DKDLKK 91 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 + L+ + + H++ +V+HRDLK N+L++A K++D Sbjct: 92 FMDTNGNKGALETKQVKWFMYQLLRGILFCHDN---RVLHRDLKPQNLLINAKGQLKLAD 148 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 FGLAR FG +N V+ T Y AP VL Sbjct: 149 FGLARAFGI-PVNTFSNEVV-TLWYRAPDVL 177
>MARK3_RAT (Q8VHF0) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| Length = 797 Score = 62.4 bits (150), Expect = 7e-10 Identities = 44/156 (28%), Positives = 76/156 (48%), Gaps = 2/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQ--GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K + K+ +++L E+ ++ L H N+V+L V ++ L+ E+ + Sbjct: 82 VAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVF 141 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + ++ + +QY H Q ++VHRDLKA N+LLDADMN KI+ Sbjct: 142 DYLVAHGRMKEKE---ARAKFRQIVSAVQYCH---QKRIVHRDLKAENLLLDADMNIKIT 195 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 DFG + F G + G+ Y AP + ++ Sbjct: 196 DFGFSNEFTVGSK---LDTFCGSPPYAAPELFQGKK 228
>STK39_HUMAN (Q9UEW8) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT) Length = 547 Score = 62.4 bits (150), Expect = 7e-10 Identities = 47/160 (29%), Positives = 77/160 (48%), Gaps = 9/160 (5%) Frame = +1 Query: 1 IAVKRLSKSSTQ-GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS-LD 174 +A+KR++ Q ++EL E+ +++ H N+V + + E LV + + S LD Sbjct: 91 VAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLD 150 Query: 175 QILFDTEKGEQ----LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMN 342 I + +GE L+ L YLH + Q +HRDLKA N+LL D + Sbjct: 151 IIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQ---IHRDLKAGNILLGEDGS 207 Query: 343 PKISDFGLARLFGRG---QTQGVTNRVIGTYGYMAPGVLD 453 +I+DFG++ G V +GT +MAP V++ Sbjct: 208 VQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVME 247
>STK39_MOUSE (Q9Z1W9) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) Length = 556 Score = 62.4 bits (150), Expect = 7e-10 Identities = 47/160 (29%), Positives = 77/160 (48%), Gaps = 9/160 (5%) Frame = +1 Query: 1 IAVKRLSKSSTQ-GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS-LD 174 +A+KR++ Q ++EL E+ +++ H N+V + + E LV + + S LD Sbjct: 101 VAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLD 160 Query: 175 QILFDTEKGEQ----LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMN 342 I + +GE L+ L YLH + Q +HRDLKA N+LL D + Sbjct: 161 IIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQ---IHRDLKAGNILLGEDGS 217 Query: 343 PKISDFGLARLFGRG---QTQGVTNRVIGTYGYMAPGVLD 453 +I+DFG++ G V +GT +MAP V++ Sbjct: 218 VQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVME 257
>MARK3_MOUSE (Q03141) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (MPK-10) (ELKL motif kinase 2) Length = 753 Score = 62.4 bits (150), Expect = 7e-10 Identities = 44/156 (28%), Positives = 76/156 (48%), Gaps = 2/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQ--GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K + K+ +++L E+ ++ L H N+V+L V ++ L+ E+ + Sbjct: 82 VAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVF 141 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + ++ + +QY H Q ++VHRDLKA N+LLDADMN KI+ Sbjct: 142 DYLVAHGRMKEKE---ARAKFRQIVSAVQYCH---QKRIVHRDLKAENLLLDADMNIKIA 195 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 DFG + F G + G+ Y AP + ++ Sbjct: 196 DFGFSNEFTVGSK---LDTFCGSPPYAAPELFQGKK 228
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 62.4 bits (150), Expect = 7e-10 Identities = 41/125 (32%), Positives = 66/125 (52%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK + KS+ + +L E+ + L+H+ L+RL +C + +V E + +L Q+ Sbjct: 259 VAVKVI-KSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNL-QV 316 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 + +G+ L + YL E +VVHRDL A NVL+ D+ K++DF Sbjct: 317 YLGSSEGKALSLPHLLGFACQVAEGMSYLEER---RVVHRDLAARNVLVGDDLTCKVADF 373 Query: 361 GLARL 375 GLARL Sbjct: 374 GLARL 378
>M3K4_MOUSE (O08648) Mitogen-activated protein kinase kinase kinase 4 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) Length = 1597 Score = 62.4 bits (150), Expect = 7e-10 Identities = 44/148 (29%), Positives = 71/148 (47%), Gaps = 2/148 (1%) Frame = +1 Query: 13 RLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDT 192 R + + ++E +EL + +KH NLVR GV L ++E + E+ +L+++ + Sbjct: 1364 RFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV---S 1420 Query: 193 EKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLA- 369 G L + LHE +VHRD+K +N+ L + K+ DFG + Sbjct: 1421 RLG--LQEHVIRLYTKQITVAINVLHEHG---IVHRDIKGANIFLTSSGLIKLGDFGCSV 1475 Query: 370 RLFGRGQTQ-GVTNRVIGTYGYMAPGVL 450 +L QT G N +GT YMAP V+ Sbjct: 1476 KLKNNAQTMPGEVNSTLGTAAYMAPEVI 1503
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 62.4 bits (150), Expect = 7e-10 Identities = 52/178 (29%), Positives = 83/178 (46%), Gaps = 10/178 (5%) Frame = +1 Query: 1 IAVKRLSKSSTQGV------EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPN 162 IAVK+++ ++ + +L+ E+ L+ LKH N+V +G CL++ + EFVP Sbjct: 1086 IAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPG 1145 Query: 163 RSLDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMN 342 S+ I+ + L + YLHE+ VVHRD+K +NV+L Sbjct: 1146 GSISSII---NRFGPLPEMVFCKYTKQILQGVAYLHENC---VVHRDIKGNNVMLMPTGI 1199 Query: 343 PKISDFGLARLFGRGQTQGVTNRVI----GTYGYMAPGVLDARELLREIGMCSASE*W 504 K+ DFG AR G + ++ GT +MAP E++ E G S+ W Sbjct: 1200 IKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAP------EVINESGYGRKSDIW 1251
>M3K4_HUMAN (Q9Y6R4) Mitogen-activated protein kinase kinase kinase 4 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1) Length = 1607 Score = 62.4 bits (150), Expect = 7e-10 Identities = 44/148 (29%), Positives = 71/148 (47%), Gaps = 2/148 (1%) Frame = +1 Query: 13 RLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDT 192 R + + ++E +EL + +KH NLVR GV L ++E + E+ +L+++ + Sbjct: 1374 RFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV---S 1430 Query: 193 EKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLA- 369 G L + LHE +VHRD+K +N+ L + K+ DFG + Sbjct: 1431 RLG--LQEHVIRLYSKQITIAINVLHEHG---IVHRDIKGANIFLTSSGLIKLGDFGCSV 1485 Query: 370 RLFGRGQTQ-GVTNRVIGTYGYMAPGVL 450 +L QT G N +GT YMAP V+ Sbjct: 1486 KLKNNAQTMPGEVNSTLGTAAYMAPEVI 1513
>CLA4_YEAST (P48562) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 842 Score = 62.4 bits (150), Expect = 7e-10 Identities = 49/169 (28%), Positives = 83/169 (49%), Gaps = 6/169 (3%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERL-LVYEFVPNRSLDQ 177 +A+K++ S E + NE+ ++ +HKN+V + L + L +V EF+ SL Sbjct: 591 VAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTD 650 Query: 178 ILFDTEKGEQ----LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNP 345 I+ ++ + L L++LH+ ++HRD+K+ NVLLD Sbjct: 651 IIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKH---IIHRDIKSDNVLLDTRARV 707 Query: 346 KISDFGL-ARLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLREIGMCS 489 KI+DFG ARL + + ++GT +MAP V+ RE +I + S Sbjct: 708 KITDFGFCARLTDKRSKRAT---MVGTPYWMAPEVVKQREYDEKIDVWS 753
>STK39_RAT (O88506) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (Pancreatic serine/threonine-protein kinase) (PS/TK) (PSTK1) Length = 553 Score = 62.4 bits (150), Expect = 7e-10 Identities = 47/160 (29%), Positives = 77/160 (48%), Gaps = 9/160 (5%) Frame = +1 Query: 1 IAVKRLSKSSTQ-GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRS-LD 174 +A+KR++ Q ++EL E+ +++ H N+V + + E LV + + S LD Sbjct: 98 VAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLD 157 Query: 175 QILFDTEKGEQ----LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMN 342 I + +GE L+ L YLH + Q +HRDLKA N+LL D + Sbjct: 158 IIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQ---IHRDLKAGNILLGEDGS 214 Query: 343 PKISDFGLARLFGRG---QTQGVTNRVIGTYGYMAPGVLD 453 +I+DFG++ G V +GT +MAP V++ Sbjct: 215 VQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVME 254
>SLK_MOUSE (O54988) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4) Length = 1233 Score = 62.0 bits (149), Expect = 9e-10 Identities = 42/149 (28%), Positives = 74/149 (49%) Frame = +1 Query: 4 AVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQIL 183 A K + S + +E+ E+ ++A H N+V+L+ + ++ EF ++D ++ Sbjct: 61 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM 120 Query: 184 FDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFG 363 + E+ L L YLH++ K++HRDLKA N+L D + K++DFG Sbjct: 121 LELER--PLTESQIQVVCKQTLEALNYLHDN---KIIHRDLKAGNILFTLDGDIKLADFG 175 Query: 364 LARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 ++ R T + IGT +MAP V+ Sbjct: 176 VSAKNTR--TIQRRDSFIGTPYWMAPEVV 202
>SLK_HUMAN (Q9H2G2) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9) Length = 1235 Score = 62.0 bits (149), Expect = 9e-10 Identities = 42/149 (28%), Positives = 74/149 (49%) Frame = +1 Query: 4 AVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQIL 183 A K + S + +E+ E+ ++A H N+V+L+ + ++ EF ++D ++ Sbjct: 61 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM 120 Query: 184 FDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFG 363 + E+ L L YLH++ K++HRDLKA N+L D + K++DFG Sbjct: 121 LELER--PLTESQIQVVCKQTLDALNYLHDN---KIIHRDLKAGNILFTLDGDIKLADFG 175 Query: 364 LARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 ++ R T + IGT +MAP V+ Sbjct: 176 VSAKNTR--TIQRRDSFIGTPYWMAPEVV 202
>MAPK_PETHY (Q40884) Mitogen-activated protein kinase homolog 1 (EC 2.7.11.24)| (PMEK1) Length = 384 Score = 62.0 bits (149), Expect = 9e-10 Identities = 50/157 (31%), Positives = 83/157 (52%), Gaps = 7/157 (4%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKN--ELALVAKLKHKNLVRLVGVCLEQQER-----LLVYEFVP 159 +A+K+++ + ++ L+ EL L+ L+H+N++ L V + Q R LVYE + Sbjct: 58 VAIKKINNAFENRIDALRTLRELKLLRHLRHENVIALKDVMMPIQRRSFKDVYLVYELM- 116 Query: 160 NRSLDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADM 339 + L QI+ + + L L+YLH + ++HRDLK N+L++A+ Sbjct: 117 DTDLHQII---KSSQTLSNDHCQYFLFQLLRGLKYLHSAN---ILHRDLKPGNLLINANC 170 Query: 340 NPKISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 + KI DFGLAR G+ Q +T V+ T Y AP +L Sbjct: 171 DLKICDFGLART-SSGKDQFMTEYVV-TRWYRAPELL 205
>CDC5_YEAST (P32562) Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC| 2.7.11.21) Length = 705 Score = 62.0 bits (149), Expect = 9e-10 Identities = 41/148 (27%), Positives = 72/148 (48%) Frame = +1 Query: 7 VKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILF 186 V + S S + ++L +E+ + + H N+V+ + + ++ E PN SL ++L Sbjct: 112 VAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELL- 170 Query: 187 DTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGL 366 ++ + L ++Y+H +V+HRDLK N+ D++ N KI DFGL Sbjct: 171 --KRRKVLTEPEVRFFTTQICGAIKYMHSR---RVIHRDLKLGNIFFDSNYNLKIGDFGL 225 Query: 367 ARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 A + + T + GT Y+AP VL Sbjct: 226 AAVLANESERKYT--ICGTPNYIAPEVL 251
>SLK_CAVPO (O55092) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1231 Score = 62.0 bits (149), Expect = 9e-10 Identities = 42/149 (28%), Positives = 74/149 (49%) Frame = +1 Query: 4 AVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQIL 183 A K + S + +E+ E+ ++A H N+V+L+ + ++ EF ++D ++ Sbjct: 61 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM 120 Query: 184 FDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFG 363 + E+ L L YLH++ K++HRDLKA N+L D + K++DFG Sbjct: 121 LELER--PLTESQIQVVCKQTLEALNYLHDN---KIIHRDLKAGNILFTLDGDIKLADFG 175 Query: 364 LARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 ++ R T + IGT +MAP V+ Sbjct: 176 VSAKNTR--TIQRRDSFIGTPYWMAPEVV 202
>SLK_RAT (O08815) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1206 Score = 62.0 bits (149), Expect = 9e-10 Identities = 42/149 (28%), Positives = 74/149 (49%) Frame = +1 Query: 4 AVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQIL 183 A K + S + +E+ E+ ++A H N+V+L+ + ++ EF ++D ++ Sbjct: 61 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM 120 Query: 184 FDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFG 363 + E+ L L YLH++ K++HRDLKA N+L D + K++DFG Sbjct: 121 LELER--PLTESQIQVVCKQTLEALNYLHDN---KIIHRDLKAGNILFTLDGDIKLADFG 175 Query: 364 LARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 ++ R T + IGT +MAP V+ Sbjct: 176 VSAKNTR--TIQRRDSFIGTPYWMAPEVV 202
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 62.0 bits (149), Expect = 9e-10 Identities = 45/169 (26%), Positives = 82/169 (48%), Gaps = 6/169 (3%) Frame = +1 Query: 1 IAVKRLSKSS---TQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +A+K L KS ++ ++++ E+ + + L+HKN++RL G +++ L+ EF L Sbjct: 115 VALKTLHKSELVQSKIEKQVRREIEIQSNLRHKNILRLYGHFHDEKRIYLILEFAGRGEL 174 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 Q L + ++ L YLH+ V+HRD+K N+LL D K+ Sbjct: 175 YQHL---RRAKRFSEEVASKYIFQMANALSYLHKKH---VIHRDIKPENILLGIDGEIKL 228 Query: 352 SDFGLARLFGRGQTQGVTNR---VIGTYGYMAPGVLDARELLREIGMCS 489 SDFG + +NR + GT Y+ P +++ +E ++ + S Sbjct: 229 SDFGWS-------VHAPSNRRTTLCGTLDYLPPEMVEGKEHTEKVDLWS 270
>CDC2H_PLAVI (Q9XZD6) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (Pvcrk2) Length = 288 Score = 62.0 bits (149), Expect = 9e-10 Identities = 43/131 (32%), Positives = 73/131 (55%) Frame = +1 Query: 58 ELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXX 237 E++++ +LKH N+V+L V ++ +LV+E + ++ L ++L + G L+ Sbjct: 50 EISILKELKHSNIVKLYDVIHTKKRLILVFEHL-DQDLKKLLDVCDGG--LESVTAKSFL 106 Query: 238 XXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVTNRVI 417 + Y HE +V+HRDLK N+L++ + KI+DFGLAR FG + T+ V+ Sbjct: 107 LQLLSGIAYCHEH---RVLHRDLKPQNLLINREGELKIADFGLARAFGI-PVRKYTHEVV 162 Query: 418 GTYGYMAPGVL 450 T Y AP +L Sbjct: 163 -TLWYRAPDIL 172
>CDC2H_PLAKH (O96821) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 62.0 bits (149), Expect = 9e-10 Identities = 43/131 (32%), Positives = 73/131 (55%) Frame = +1 Query: 58 ELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXX 237 E++++ +LKH N+V+L V ++ +LV+E + ++ L ++L + G L+ Sbjct: 50 EISILKELKHSNIVKLYDVIHTKKRLILVFEHL-DQDLKKLLDVCDGG--LESVTAKSFL 106 Query: 238 XXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVTNRVI 417 + Y HE +V+HRDLK N+L++ + KI+DFGLAR FG + T+ V+ Sbjct: 107 LQLLSGIAYCHEH---RVLHRDLKPQNLLINREGELKIADFGLARAFGI-PVRKYTHEVV 162 Query: 418 GTYGYMAPGVL 450 T Y AP +L Sbjct: 163 -TLWYRAPDIL 172
>SN1L1_MOUSE (Q60670) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1-like kinase) Length = 779 Score = 62.0 bits (149), Expect = 9e-10 Identities = 43/156 (27%), Positives = 75/156 (48%), Gaps = 2/156 (1%) Frame = +1 Query: 1 IAVKRLSKS--STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K + K+ + +E++ E+ L+ L H N+++L V + +V EF N + Sbjct: 53 VAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMF 112 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L T G L ++Y H +VHRDLK N+LLD++M+ K++ Sbjct: 113 DYL--TSNGH-LSENEARQKFWQILSAVEYCHNHH---IVHRDLKTENLLLDSNMDIKLA 166 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 DFG + G+ + +G+ Y AP V + +E Sbjct: 167 DFGFGNFYKPGEP---LSTCVGSPPYAAPEVFEGKE 199
>CDK3_HUMAN (Q00526) Cell division protein kinase 3 (EC 2.7.11.22)| Length = 305 Score = 61.6 bits (148), Expect = 1e-09 Identities = 43/131 (32%), Positives = 73/131 (55%) Frame = +1 Query: 58 ELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXX 237 E++L+ +LKH N+VRL+ V +++ LV+EF+ ++ L + + D+ G +L Sbjct: 51 EISLLKELKHPNIVRLLDVVHNERKLYLVFEFL-SQDLKKYM-DSTPGSELPLHLIKSYL 108 Query: 238 XXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVTNRVI 417 + + H +V+HRDLK N+L++ K++DFGLAR FG + T+ V+ Sbjct: 109 FQLLQGVSFCHSH---RVIHRDLKPQNLLINELGAIKLADFGLARAFG-VPLRTYTHEVV 164 Query: 418 GTYGYMAPGVL 450 T Y AP +L Sbjct: 165 -TLWYRAPEIL 174
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 61.6 bits (148), Expect = 1e-09 Identities = 46/156 (29%), Positives = 73/156 (46%), Gaps = 3/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQ--GVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +A+K L KS + GVE +L+ E+ + A LKH N+++L +QQ L+ E+ P L Sbjct: 108 VALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGEL 167 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + + +K D L Y H+ KV+HRD+K N+LL KI Sbjct: 168 YK---ELQKSRTFDEQRTATIMEELSDALTYCHKK---KVIHRDIKPENLLLGLQGELKI 221 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 +DFG + + GT Y+ P +++ R Sbjct: 222 ADFG----WSVHAPSLRRKTMCGTLDYLPPEMIEGR 253
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 61.6 bits (148), Expect = 1e-09 Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 3/153 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K + SS + L E+ L+ +L H N++R +GVC+ Q + + E++ + +L+Q+ Sbjct: 84 MALKMNTLSSNRA--NLLKEMQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQL 141 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMN---PKI 351 L + L W L YLH + HRDL + N L+ D N + Sbjct: 142 L---DSDLYLPWTVRVKLAYDIAVGLSYLHFKG---IFHRDLTSKNCLIKRDENGYSAVV 195 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 +DFGLA V+G+ +MAP VL Sbjct: 196 ADFGLAEKIPDASIGREKLAVVGSPFWMAPEVL 228
>CDC2_CAEEL (P34556) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 332 Score = 61.6 bits (148), Expect = 1e-09 Identities = 48/155 (30%), Positives = 81/155 (52%), Gaps = 5/155 (3%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVP---NR 165 +A+K++ +S +GV E++L+ +L+H N+V L V +++ L++EF+ R Sbjct: 48 VAMKKIRLESEDEGVPSTAVREISLLKELQHPNVVGLEAVIMQENRLFLIFEFLSFDLKR 107 Query: 166 SLDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNP 345 +DQ+ K E L + + H Q +V+HRDLK N+L+D + Sbjct: 108 YMDQL----GKDEYLPLETLKSYTFQILQAMCFCH---QRRVIHRDLKPQNLLVDNNGAI 160 Query: 346 KISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 K++DFGLAR G + T+ V+ T Y AP +L Sbjct: 161 KLADFGLARAIGI-PIRVYTHEVV-TLWYRAPEIL 193
>SN1L2_MOUSE (Q8CFH6) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Salt-inducible kinase 2) Length = 931 Score = 61.6 bits (148), Expect = 1e-09 Identities = 46/156 (29%), Positives = 73/156 (46%), Gaps = 2/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGV--EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K + KS V E++ E+ ++ L H ++++L V + LV E+ N + Sbjct: 46 VAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIF 105 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + + L+ + Y H KVVHRDLKA N+LLD +MN KI+ Sbjct: 106 DYLANHGR---LNESEARRKFWQILSAVDYCHGR---KVVHRDLKAENLLLDNNMNIKIA 159 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 DFG F G+ G+ Y AP V + ++ Sbjct: 160 DFGFGNFFKTGELLATW---CGSPPYAAPEVFEGQQ 192
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 61.6 bits (148), Expect = 1e-09 Identities = 37/152 (24%), Positives = 80/152 (52%), Gaps = 5/152 (3%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQ-ERLLVYEFVPNRSLDQ 177 IA++ L + + + + + +++H+NLV L ++ E+LL+Y+++PN SL Sbjct: 398 IALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRAFYQGKRGEKLLIYDYLPNISLHD 457 Query: 178 ILFDTE-KGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 +L +++ + L+W L YLH ++ ++H ++++ NVL+D +++ Sbjct: 458 LLHESKPRKPALNWARRHKIALGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLT 517 Query: 355 DFGLARLFGRGQTQGVTNRVIG---TYGYMAP 441 +FGL ++ Q V + ++ + GY AP Sbjct: 518 EFGLDKI----MVQAVADEIVSQAKSDGYKAP 545
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 61.6 bits (148), Expect = 1e-09 Identities = 47/157 (29%), Positives = 78/157 (49%), Gaps = 4/157 (2%) Frame = +1 Query: 1 IAVKRLSKSSTQ--GVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +A+K L KS + G+E +L+ E+ + A L+H N++RL + + L+ E+ P L Sbjct: 69 VALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGEL 128 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + L +K E+LD L Y H+ KV+HRD+K N+LL KI Sbjct: 129 YKEL---QKSEKLDEQRTATIIEELADALTYCHDK---KVIHRDIKPENLLLGFRGEVKI 182 Query: 352 SDFGLARLFGRGQTQGVTNRVI-GTYGYMAPGVLDAR 459 +DFG + T + + + GT Y+ P +++ R Sbjct: 183 ADFGWS-----VHTPSLRRKTMCGTLDYLPPEMIEGR 214
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 61.6 bits (148), Expect = 1e-09 Identities = 46/152 (30%), Positives = 79/152 (51%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ +S +GV E++L+ +L+H N+V L V ++ L++EF+ + L Sbjct: 30 VAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ +D + + H +V+HRDLK N+L+D K++ Sbjct: 89 KYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHSR---RVLHRDLKPQNLLIDDKGTIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y +P VL Sbjct: 146 DFGLARAFGI-PIRVYTHEVV-TLWYRSPEVL 175
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 61.6 bits (148), Expect = 1e-09 Identities = 46/152 (30%), Positives = 79/152 (51%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ +S +GV E++L+ +L+H N+V L V ++ L++EF+ + L Sbjct: 30 VAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ +D + + H +V+HRDLK N+L+D K++ Sbjct: 89 KYLDSIPPGQFMDSSLVKSYLHQILQGIVFCHSR---RVLHRDLKPQNLLIDDKGTIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y +P VL Sbjct: 146 DFGLARAFGI-PIRVYTHEVV-TLWYRSPEVL 175
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 61.6 bits (148), Expect = 1e-09 Identities = 46/152 (30%), Positives = 79/152 (51%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ +S +GV E++L+ +L+H N+V L V ++ L++EF+ + L Sbjct: 30 VAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ +D + + H +V+HRDLK N+L+D K++ Sbjct: 89 KYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHSR---RVLHRDLKPQNLLIDDKGTIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y +P VL Sbjct: 146 DFGLARAFGI-PIRVYTHEVV-TLWYRSPEVL 175
>CDC2H_PLAFK (Q07785) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (PfPK5) Length = 288 Score = 61.2 bits (147), Expect = 2e-09 Identities = 44/131 (33%), Positives = 73/131 (55%) Frame = +1 Query: 58 ELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXX 237 E++++ +LKH N+V+L V ++ +LV+E + ++ L ++L E G L+ Sbjct: 50 EISILKELKHSNIVKLYDVIHTKKRLVLVFEHL-DQDLKKLLDVCEGG--LESVTAKSFL 106 Query: 238 XXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVTNRVI 417 + Y H+ +V+HRDLK N+L++ + KI+DFGLAR FG + T+ V+ Sbjct: 107 LQLLNGIAYCHDR---RVLHRDLKPQNLLINREGELKIADFGLARAFGI-PVRKYTHEVV 162 Query: 418 GTYGYMAPGVL 450 T Y AP VL Sbjct: 163 -TLWYRAPDVL 172
>CDC2H_PLAF7 (P61075) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 61.2 bits (147), Expect = 2e-09 Identities = 44/131 (33%), Positives = 73/131 (55%) Frame = +1 Query: 58 ELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXX 237 E++++ +LKH N+V+L V ++ +LV+E + ++ L ++L E G L+ Sbjct: 50 EISILKELKHSNIVKLYDVIHTKKRLVLVFEHL-DQDLKKLLDVCEGG--LESVTAKSFL 106 Query: 238 XXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVTNRVI 417 + Y H+ +V+HRDLK N+L++ + KI+DFGLAR FG + T+ V+ Sbjct: 107 LQLLNGIAYCHDR---RVLHRDLKPQNLLINREGELKIADFGLARAFGI-PVRKYTHEVV 162 Query: 418 GTYGYMAPGVL 450 T Y AP VL Sbjct: 163 -TLWYRAPDVL 172
>AVR2A_XENLA (P27039) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type II) (ACTR-II) Length = 514 Score = 61.2 bits (147), Expect = 2e-09 Identities = 44/143 (30%), Positives = 66/143 (46%), Gaps = 11/143 (7%) Frame = +1 Query: 58 ELALVAKLKHKNLVRLVGVCLE----QQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXX 225 E+ + +KH+N++ +G + L+ F SL L K + W Sbjct: 235 EIYSLPGMKHENILYFIGAEKRGTNLDTDLWLITAFHEKGSLTDYL----KANVVSWNEL 290 Query: 226 XXXXXXXXXXLQYLHED-------SQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGR 384 L +LHED + V HRD+K+ NVLL ++ I+DFGLA F Sbjct: 291 CLIAETMARGLSHLHEDIPGLKDGHKPAVAHRDIKSKNVLLKNNLTACIADFGLALKFEA 350 Query: 385 GQTQGVTNRVIGTYGYMAPGVLD 453 G++ G T+ +GT YMAP VL+ Sbjct: 351 GKSAGDTHGQVGTRRYMAPEVLE 373
>CRK1_LEIME (Q06309) Cell division protein kinase 2 homolog CRK1 (EC 2.7.11.23)| Length = 301 Score = 61.2 bits (147), Expect = 2e-09 Identities = 46/152 (30%), Positives = 76/152 (50%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+KR+ S +GV E++L+ +L+H+N+V+L+ VC + +V+E++ LD Sbjct: 31 VALKRIRLDSEEEGVPCTAIREISLLKELRHENIVKLLDVCHSEHRLTIVFEYL---DLD 87 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + + LD + + H+ S V+HRDLK N+L+ + K+ Sbjct: 88 LKKYLDRENGNLDAATIQHFMRDLLRGVAFCHQRS---VLHRDLKPQNLLISREKELKLG 144 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGL R F + TN V+ T Y P VL Sbjct: 145 DFGLGRSFAI-PVRKFTNEVV-TLWYRPPDVL 174
>ZYG1_CAEBR (Q621J7) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 709 Score = 61.2 bits (147), Expect = 2e-09 Identities = 43/153 (28%), Positives = 77/153 (50%), Gaps = 4/153 (2%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K++ +++Q +K E+ + L+H+N+V+ E E LV E SL + Sbjct: 38 VAIKKIGNAASQ--TRIKEEIKTMKLLRHRNIVQFYETFFENGETYLVMELCEGGSL--M 93 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL----DADMNPK 348 + +KG LD ++Y+H+++ ++HRDL A NV + + + K Sbjct: 94 DYVKQKG-PLDDSTAVHILRQLIAAVKYIHDEN---ILHRDLSAGNVFIKDATKSTITVK 149 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGV 447 + DFGLA G+ G ++GT G++AP V Sbjct: 150 LGDFGLATNLGQ---HGTACTIVGTPGFIAPQV 179
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 61.2 bits (147), Expect = 2e-09 Identities = 44/154 (28%), Positives = 79/154 (51%), Gaps = 7/154 (4%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKN----LVRLVGVCLEQQERLLVYEFVPNRS 168 +AVK L T ++ +N++ A++ HK ++ ++G+C E + +V E++PN S Sbjct: 44 VAVKHLH-IHTPLLDSERNDILREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGS 102 Query: 169 LDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPK 348 L+++L + + W + YLH + ++H DLK N+LLD + + K Sbjct: 103 LNELLHRKTEYPDIAWPLRFRILHEIALGVNYLHNMNP-PLLHHDLKTQNILLDNEFHVK 161 Query: 349 ISDFGLA--RLFGRGQTQGVTNRVI-GTYGYMAP 441 I+DFGL+ R+ Q++ + GT YM P Sbjct: 162 IADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPP 195
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 61.2 bits (147), Expect = 2e-09 Identities = 45/156 (28%), Positives = 75/156 (48%), Gaps = 2/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQ--GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK + K+ +++L E+ ++ L H N+V+L V ++ LV E+ + Sbjct: 86 VAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVF 145 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + ++ + +QY H+ +VHRDLKA N+LLDADMN KI+ Sbjct: 146 DYLVAHGRMKEKE---ARAKFRQIVSAVQYCHQKC---IVHRDLKAENLLLDADMNIKIA 199 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 DFG + F G + G+ Y AP + ++ Sbjct: 200 DFGFSNEFTVGNK---LDTFCGSPPYAAPELFQGKK 232
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 61.2 bits (147), Expect = 2e-09 Identities = 50/152 (32%), Positives = 78/152 (51%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ + T+GV E++L+ +L H N+V+L+ V + + LV+EF L Sbjct: 30 VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEF-----LH 84 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 Q L L LQ L +V+HRDLK N+L++AD + K++ Sbjct: 85 QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINADGSIKLA 144 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y AP +L Sbjct: 145 DFGLARAFG-VPVRTYTHEVV-TLWYRAPEIL 174
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 61.2 bits (147), Expect = 2e-09 Identities = 45/156 (28%), Positives = 75/156 (48%), Gaps = 2/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQ--GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK + K+ +++L E+ ++ L H N+V+L V ++ LV E+ + Sbjct: 86 VAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVF 145 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + ++ + +QY H+ +VHRDLKA N+LLDADMN KI+ Sbjct: 146 DYLVAHGRMKEKE---ARAKFRQIVSAVQYCHQKC---IVHRDLKAENLLLDADMNIKIA 199 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 DFG + F G + G+ Y AP + ++ Sbjct: 200 DFGFSNEFTVGNK---LDTFCGSPPYAAPELFQGKK 232
>SN1L2_HUMAN (Q9H0K1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 926 Score = 61.2 bits (147), Expect = 2e-09 Identities = 45/156 (28%), Positives = 73/156 (46%), Gaps = 2/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGV--EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K + KS V E++ E+ ++ L H ++++L V + LV E+ N + Sbjct: 46 VAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIF 105 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + + L+ + Y H K+VHRDLKA N+LLD +MN KI+ Sbjct: 106 DYLANHGR---LNESEARRKFWQILSAVDYCHGR---KIVHRDLKAENLLLDNNMNIKIA 159 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 DFG F G+ G+ Y AP V + ++ Sbjct: 160 DFGFGNFFKSGELLATW---CGSPPYAAPEVFEGQQ 192
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 61.2 bits (147), Expect = 2e-09 Identities = 38/116 (32%), Positives = 63/116 (54%) Frame = +1 Query: 25 SSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGE 204 +++ V L E A + K+K +++V + GVC +Q +V EF+ N SL+++L Sbjct: 60 AASSDVNYLIEEAAKMKKIKFQHIVSIYGVC--KQPLGIVMEFMANGSLEKVL----STH 113 Query: 205 QLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLAR 372 L W + +LH ++H DLK N+LLD++M+ KISDFGL++ Sbjct: 114 SLCWKLRFRIIHETSLAMNFLHSIKP-PLLHLDLKPGNILLDSNMHVKISDFGLSK 168
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 61.2 bits (147), Expect = 2e-09 Identities = 46/169 (27%), Positives = 80/169 (47%), Gaps = 1/169 (0%) Frame = +1 Query: 1 IAVKRLSKS-STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L S + + +E +++ + H N++RL GV + + +++ EF+ N +LD Sbjct: 566 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDS 625 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L + Q ++YL S++ VHRDL A N+L+++++ K+SD Sbjct: 626 FL--RQNDGQFTVIQLVGMLRGIAAGMKYL---SEMNYVHRDLAARNILVNSNLVCKVSD 680 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLREIGMCSASE*W 504 FGL+R Q + G P A E +R SAS+ W Sbjct: 681 FGLSRYL---QDDTSDPTYTSSLGGKIPVRWTAPEAIRYRKFTSASDVW 726
>RAD53_YEAST (P22216) Serine/threonine-protein kinase RAD53 (EC 2.7.11.1)| (Serine-protein kinase 1) Length = 821 Score = 61.2 bits (147), Expect = 2e-09 Identities = 48/157 (30%), Positives = 75/157 (47%), Gaps = 4/157 (2%) Frame = +1 Query: 4 AVKRLSKSSTQG-VEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL-DQ 177 AVK +SK G ++ + EL ++ KL H +VRL G + + +V EFV L D Sbjct: 225 AVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDF 284 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDAD--MNPKI 351 + GE ++Y+H + + HRDLK N+L++ D + KI Sbjct: 285 VAAHGAVGED----AGREISRQILTAIKYIH---SMGISHRDLKPDNILIEQDDPVLVKI 337 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 +DFGLA++ G G GT Y+AP V+ ++ Sbjct: 338 TDFGLAKVQGNG---SFMKTFCGTLAYVAPEVIRGKD 371
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/124 (33%), Positives = 65/124 (52%), Gaps = 3/124 (2%) Frame = +1 Query: 1 IAVKRLSKSSTQ--GVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +A+K L KS + G+E +L+ E+ + A L+H+N++RL + L+ E+ P L Sbjct: 42 VALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRNILRLYNYFYDDTRIYLILEYAPGGEL 101 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + L ++ ++LD L Y HE KV+HRD+K N+LL + KI Sbjct: 102 YKEL---QRHQKLDQQRTATIIQELSDALTYCHEK---KVIHRDIKPENLLLGLNGEVKI 155 Query: 352 SDFG 363 SDFG Sbjct: 156 SDFG 159
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 61.2 bits (147), Expect = 2e-09 Identities = 44/139 (31%), Positives = 74/139 (53%), Gaps = 3/139 (2%) Frame = +1 Query: 43 EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXX 222 EE+ NE++L+ L H N+++L V +++ LV EF L + + + K ++ D Sbjct: 110 EEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECD--- 166 Query: 223 XXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLD---ADMNPKISDFGLARLFGRGQT 393 + YLH+ + +VHRD+K N+LL+ + +N KI DFGL+ F + Sbjct: 167 AANIMKQILSGICYLHKHN---IVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNK 223 Query: 394 QGVTNRVIGTYGYMAPGVL 450 + +R +GT Y+AP VL Sbjct: 224 --LRDR-LGTAYYIAPEVL 239
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 61.2 bits (147), Expect = 2e-09 Identities = 44/139 (31%), Positives = 74/139 (53%), Gaps = 3/139 (2%) Frame = +1 Query: 43 EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXX 222 EE+ NE++L+ L H N+++L V +++ LV EF L + + + K ++ D Sbjct: 110 EEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECD--- 166 Query: 223 XXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLD---ADMNPKISDFGLARLFGRGQT 393 + YLH+ + +VHRD+K N+LL+ + +N KI DFGL+ F + Sbjct: 167 AANIMKQILSGICYLHKHN---IVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNK 223 Query: 394 QGVTNRVIGTYGYMAPGVL 450 + +R +GT Y+AP VL Sbjct: 224 --LRDR-LGTAYYIAPEVL 239
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 61.2 bits (147), Expect = 2e-09 Identities = 46/156 (29%), Positives = 73/156 (46%), Gaps = 3/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQ--GVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +A+K L KS + GVE +L+ E+ + A LKH N+++L +QQ L+ E+ P L Sbjct: 106 VALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGEL 165 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + + +K D L Y H+ KV+HRD+K N+LL KI Sbjct: 166 YK---ELQKSGTFDEQRTATIMEELSDALMYCHKK---KVIHRDIKPENLLLGLQGELKI 219 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 +DFG + + GT Y+ P +++ R Sbjct: 220 ADFG----WSVHAPSLRRKTMCGTLDYLPPEMIEGR 251
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 61.2 bits (147), Expect = 2e-09 Identities = 46/152 (30%), Positives = 81/152 (53%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ ++ +GV E++L+ +L+H N+V L+ V ++ L++EF+ + L Sbjct: 30 VAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDVLMQDSRLYLIFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ L+ + + H +V+HRDLK N+L+D+ K++ Sbjct: 89 KYLDSIPSGQYLEAMLVKSYLYQILQGIIFCHAR---RVLHRDLKPQNLLIDSKGVIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y AP VL Sbjct: 146 DFGLARAFGI-PVRVYTHEVV-TLWYRAPEVL 175
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 60.8 bits (146), Expect = 2e-09 Identities = 45/151 (29%), Positives = 77/151 (50%), Gaps = 1/151 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K +S S +G E++L+ +L H+N+V L V + + LV+E++ ++ L + Sbjct: 34 VALKEISLDSEEGTPSTAIREISLMKELDHENIVTLYDVIHTENKLTLVFEYM-DKDLKK 92 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 + + LD + + H++ +V+HRDLK N+L++ K+ D Sbjct: 93 YMEVHGQQSALDLKVVKSFMFQLLKGIMFCHDN---RVLHRDLKPQNLLINNKGELKLGD 149 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 FGLAR FG +N V+ T Y AP VL Sbjct: 150 FGLARAFGI-PFNTFSNEVV-TLWYRAPDVL 178
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 60.8 bits (146), Expect = 2e-09 Identities = 47/173 (27%), Positives = 82/173 (47%), Gaps = 5/173 (2%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L T + +E +++ + H N++RL GV + + +++ E++ N SLD Sbjct: 24 VAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIRLEGVVTKCKPVMIITEYMENGSLDA 83 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L + + ++YL S + VHRDL A N+L+++++ K+SD Sbjct: 84 FL--RKNDGRFTVIQLVGILRGIASGMKYL---SDMSYVHRDLAARNILVNSNLVCKVSD 138 Query: 358 FGLARLFGRGQTQGVTNR-VIGTY---GYMAPGVLDARELLREIGMCSASE*W 504 FG++R+ T R + GTY G P A E + SAS+ W Sbjct: 139 FGMSRVLEEDPDAAYTTREITGTYQSQGGKIPIRWTAPEAITYRKFTSASDVW 191
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 60.8 bits (146), Expect = 2e-09 Identities = 44/153 (28%), Positives = 73/153 (47%), Gaps = 3/153 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K + SS + + E+ L+ +L H N++R +GVC+ Q + + E++ + +L+Q+ Sbjct: 84 MALKMNTLSSNRA--NMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQL 141 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMN---PKI 351 L + L W L YLH + HRDL + N L+ D N + Sbjct: 142 L---DSNLHLPWTVRVKLAYDIAVGLSYLHFKG---IFHRDLTSKNCLIKRDENGYSAVV 195 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 +DFGLA V+G+ +MAP VL Sbjct: 196 ADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVL 228
>CIPK1_ARATH (Q8RWC9) CBL-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (SOS2-like protein kinase PKS13) (SNF1-related kinase 3.16) Length = 444 Score = 60.8 bits (146), Expect = 2e-09 Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 3/155 (1%) Frame = +1 Query: 4 AVKRLSKSSTQGVE---ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 AVK + KS + ++K E+ + LKH ++VRL V + + +V E V L Sbjct: 47 AVKIIDKSRIADLNFSLQIKREIRTLKMLKHPHIVRLHEVLASKTKINMVMELVTGGELF 106 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + K + D + Y H V HRDLK NVLLDA + KI+ Sbjct: 107 DRIVSNGKLTETD---GRKMFQQLIDGISYCHSKG---VFHRDLKLENVLLDAKGHIKIT 160 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDAR 459 DFGL+ L + G+ + G+ Y+AP VL R Sbjct: 161 DFGLSALPQHFRDDGLLHTTCGSPNYVAPEVLANR 195
>PAK2_RAT (Q64303) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p62-PAK) Length = 524 Score = 60.8 bits (146), Expect = 2e-09 Identities = 41/150 (27%), Positives = 78/150 (52%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+++ E + NE+ ++ +LK+ N+V + L E +V E++ SL + Sbjct: 275 VAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDV 334 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 + +T +D L++LH + +V+HRD+K+ NVLL + + K++DF Sbjct: 335 VTET----CMDEAQIAAVCRECLQALEFLHAN---QVIHRDIKSDNVLLGMEGSVKLTDF 387 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 G Q++ T ++GT +MAP V+ Sbjct: 388 GFCAQITPEQSKRST--MVGTPYWMAPEVV 415
>PAK2_RABIT (Q29502) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p21-activated protein kinase I) (PAKI) Length = 524 Score = 60.8 bits (146), Expect = 2e-09 Identities = 41/150 (27%), Positives = 78/150 (52%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+++ E + NE+ ++ +LK+ N+V + L E +V E++ SL + Sbjct: 275 VAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDV 334 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 + +T +D L++LH + +V+HRD+K+ NVLL + + K++DF Sbjct: 335 VTET----CMDEAQIAAVCRECLQALEFLHAN---QVIHRDIKSDNVLLGMEGSVKLTDF 387 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 G Q++ T ++GT +MAP V+ Sbjct: 388 GFCAQITPEQSKRST--MVGTPYWMAPEVV 415
>PAK2_MOUSE (Q8CIN4) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) Length = 524 Score = 60.8 bits (146), Expect = 2e-09 Identities = 41/150 (27%), Positives = 78/150 (52%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+++ E + NE+ ++ +LK+ N+V + L E +V E++ SL + Sbjct: 275 VAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDV 334 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 + +T +D L++LH + +V+HRD+K+ NVLL + + K++DF Sbjct: 335 VTET----CMDEAQIAAVCRECLQALEFLHAN---QVIHRDIKSDNVLLGMEGSVKLTDF 387 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 G Q++ T ++GT +MAP V+ Sbjct: 388 GFCAQITPEQSKRST--MVGTPYWMAPEVV 415
>PAK2_HUMAN (Q13177) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 60.8 bits (146), Expect = 2e-09 Identities = 41/150 (27%), Positives = 78/150 (52%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K+++ E + NE+ ++ +LK+ N+V + L E +V E++ SL + Sbjct: 275 VAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDV 334 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 + +T +D L++LH + +V+HRD+K+ NVLL + + K++DF Sbjct: 335 VTET----CMDEAQIAAVCRECLQALEFLHAN---QVIHRDIKSDNVLLGMEGSVKLTDF 387 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 G Q++ T ++GT +MAP V+ Sbjct: 388 GFCAQITPEQSKRST--MVGTPYWMAPEVV 415
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 60.8 bits (146), Expect = 2e-09 Identities = 42/125 (33%), Positives = 64/125 (51%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K + KS+ + +L E+ + L+H+ L+RL VC + +V E + +L Q Sbjct: 255 VAIKVI-KSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNL-QA 312 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 T +G L + YL E +VVHRDL A NVL+D + K++DF Sbjct: 313 FLGTPEGRALRLPPLLGFACQVAEGMSYLEEQ---RVVHRDLAARNVLVDDGLACKVADF 369 Query: 361 GLARL 375 GLARL Sbjct: 370 GLARL 374
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 60.8 bits (146), Expect = 2e-09 Identities = 44/139 (31%), Positives = 74/139 (53%), Gaps = 3/139 (2%) Frame = +1 Query: 43 EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXX 222 EE+ NE++L+ L H N+++L V +++ LV EF L + + + K ++ D Sbjct: 109 EEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECD--- 165 Query: 223 XXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLD---ADMNPKISDFGLARLFGRGQT 393 + YLH+ + +VHRD+K N+LL+ + +N KI DFGL+ F + Sbjct: 166 AANIMKQILSGICYLHKHN---IVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYK 222 Query: 394 QGVTNRVIGTYGYMAPGVL 450 + +R +GT Y+AP VL Sbjct: 223 --LRDR-LGTAYYIAPEVL 238
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 60.8 bits (146), Expect = 2e-09 Identities = 42/155 (27%), Positives = 69/155 (44%) Frame = +1 Query: 40 VEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWX 219 V + E ++++L H V+L + ++ + N L + + K D Sbjct: 127 VPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYI---RKIGSFDET 183 Query: 220 XXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQG 399 L+YLH ++HRDLK N+LL+ DM+ +I+DFG A++ Q Sbjct: 184 CTRFYTAEIVSALEYLHGKG---IIHRDLKPENILLNEDMHIQITDFGTAKVLSPDSKQA 240 Query: 400 VTNRVIGTYGYMAPGVLDARELLREIGMCSASE*W 504 N +GT Y++P ELL E C +S+ W Sbjct: 241 RANSFVGTAQYVSP------ELLTEKSACKSSDLW 269
>CDC2_PONPY (Q5RCH1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 60.8 bits (146), Expect = 2e-09 Identities = 44/144 (30%), Positives = 73/144 (50%), Gaps = 1/144 (0%) Frame = +1 Query: 22 KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEK 198 +S +GV E++L+ +L+H N+V L V ++ L++EF+ + L + L Sbjct: 38 ESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPP 96 Query: 199 GEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLF 378 G+ +D + + H +V+HRDLK N+L+D K++DFGLAR F Sbjct: 97 GQYMDSSLVKSYLYQILQGIVFCHSR---RVLHRDLKPQNLLIDDKGTIKLADFGLARAF 153 Query: 379 GRGQTQGVTNRVIGTYGYMAPGVL 450 G + T+ V+ T Y +P VL Sbjct: 154 GI-PIRVYTHEVV-TLWYRSPEVL 175
>CDK5_DROME (P48609) Cell division protein kinase 5 homolog (EC 2.7.11.22)| Length = 294 Score = 60.8 bits (146), Expect = 2e-09 Identities = 46/132 (34%), Positives = 69/132 (52%), Gaps = 5/132 (3%) Frame = +1 Query: 1 IAVKRLS-KSSTQGV-EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+KR+ +GV E+ L+ +LKHKN+VRL+ V ++ LV+E D Sbjct: 30 VALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLIDVLHSDKKLTLVFEHC-----D 84 Query: 175 QIL---FDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNP 345 Q L FD+ GE +D L + H + V+HRDLK N+L++ + Sbjct: 85 QDLKKYFDSLNGE-IDMAVCRSFMLQLLRGLAFCHSHN---VLHRDLKPQNLLINKNGEL 140 Query: 346 KISDFGLARLFG 381 K++DFGLAR FG Sbjct: 141 KLADFGLARAFG 152
>PHO85_CANGA (Q6FKD4) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 302 Score = 60.5 bits (145), Expect = 3e-09 Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 4/154 (2%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K + S +G E++L+ +LKH N+VRL V + + LV+E++ N L + Sbjct: 32 VALKEVKLDSEEGTPSTAIREISLMKELKHDNIVRLYDVIHTENKLTLVFEYMDN-DLKK 90 Query: 178 ILFDTEKGEQ---LDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPK 348 + G L+ L + HE+ K++HRDLK N+L+ K Sbjct: 91 YMDSRTVGNAPRGLEMNLVKYFQWQLLEGLAFCHEN---KILHRDLKPQNLLITKRGQLK 147 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 + DFGLAR FG ++ V+ T Y AP VL Sbjct: 148 LGDFGLARAFGI-PVNTFSSEVV-TLWYRAPDVL 179
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 60.5 bits (145), Expect = 3e-09 Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 2/127 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQER--LLVYEFVPNRSLD 174 +AVK+L S+ + + + + E+ ++ L+H N+V+ GVC R L+ E++P SL Sbjct: 879 VAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLR 938 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + E++D ++YL + +HRDL N+L++ + KI Sbjct: 939 DYL--QKHKERIDHKKLLQYTSQICKGMEYL---GTKRYIHRDLATRNILVENENRVKIG 993 Query: 355 DFGLARL 375 DFGL ++ Sbjct: 994 DFGLTKV 1000 Score = 44.7 bits (104), Expect = 2e-04 Identities = 37/131 (28%), Positives = 62/131 (47%), Gaps = 8/131 (6%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 + +K L K+ E +++++L HK+LV GVC+ +E +LV EFV SLD Sbjct: 578 VLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTY 637 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADM-----NP 345 L + + W + +L E S ++H ++ A N+LL + NP Sbjct: 638 LKKNKNSINILW--KLGVAKQLAWAMHFLEEKS---LIHGNVCAKNILLIREEDRRTGNP 692 Query: 346 ---KISDFGLA 369 K+SD G++ Sbjct: 693 PFIKLSDPGIS 703
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 60.5 bits (145), Expect = 3e-09 Identities = 45/124 (36%), Positives = 60/124 (48%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 IAVK L K + E E A++ L HKNLVRL+GVC + ++ EF+ N +L + Sbjct: 337 IAVKAL-KEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEY 395 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 L T+K L + YL +HRDL A N L+ KI+DF Sbjct: 396 LRRTDK-SLLPPIILVQMASQIASGMSYL---EARHFIHRDLAARNCLVSEHNIVKIADF 451 Query: 361 GLAR 372 GLAR Sbjct: 452 GLAR 455
>HUNK_MOUSE (O88866) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Length = 714 Score = 60.5 bits (145), Expect = 3e-09 Identities = 41/147 (27%), Positives = 68/147 (46%) Frame = +1 Query: 10 KRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFD 189 K+ +K T + L+ E + ++H N+ +L+ + + LV E P +L +++ Sbjct: 95 KKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYE 154 Query: 190 TEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLA 369 ++ LD +++LH VVHRDLK N+LLD D N K+ DFGL+ Sbjct: 155 KKR---LDEAEARRYIRQLISAVEHLHRAG---VVHRDLKIENLLLDEDNNIKLIDFGLS 208 Query: 370 RLFGRGQTQGVTNRVIGTYGYMAPGVL 450 G + G+ Y AP +L Sbjct: 209 NCAGILGYSDPFSTQCGSPAYAAPELL 235
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 60.5 bits (145), Expect = 3e-09 Identities = 42/155 (27%), Positives = 69/155 (44%) Frame = +1 Query: 40 VEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWX 219 V + E ++++L H V+L + ++ + N L + + K D Sbjct: 124 VPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYI---RKIGSFDET 180 Query: 220 XXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQG 399 L+YLH ++HRDLK N+LL+ DM+ +I+DFG A++ Q Sbjct: 181 CTRFYTAEIVSALEYLHGKG---IIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQA 237 Query: 400 VTNRVIGTYGYMAPGVLDARELLREIGMCSASE*W 504 N +GT Y++P ELL E C +S+ W Sbjct: 238 RANSFVGTAQYVSP------ELLTEKSACKSSDLW 266
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 60.5 bits (145), Expect = 3e-09 Identities = 39/138 (28%), Positives = 68/138 (49%), Gaps = 1/138 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L T+ + E +++ + H N++RL GV + + ++V E++ N SLD Sbjct: 650 VAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPEMIVTEYMENGSLDS 709 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L + Q ++YL S + VHRDL A N+L+++++ K+SD Sbjct: 710 FL--RKHDAQFTVIQLVGMLRGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSD 764 Query: 358 FGLARLFGRGQTQGVTNR 411 FGL+R+ T R Sbjct: 765 FGLSRVLEDDPEAAYTTR 782
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 60.5 bits (145), Expect = 3e-09 Identities = 42/126 (33%), Positives = 67/126 (53%), Gaps = 1/126 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L T+ + +E +++ + H N++RL GV + ++V E++ N SLD Sbjct: 664 VAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDT 723 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L T G Q ++YL S L VHRDL A NVL+D+++ K+SD Sbjct: 724 FL-RTHDG-QFTIMQLVGMLRGVGAGMRYL---SDLGYVHRDLAARNVLVDSNLVCKVSD 778 Query: 358 FGLARL 375 FGL+R+ Sbjct: 779 FGLSRV 784
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 60.5 bits (145), Expect = 3e-09 Identities = 47/154 (30%), Positives = 74/154 (48%), Gaps = 5/154 (3%) Frame = +1 Query: 4 AVKRLSKSSTQGVEEL-KNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 A+K + K+ G E L +NE++++ ++KH N++ LV E LV E V L Sbjct: 421 ALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDA 480 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL----DADMNPK 348 + + K + D L+YLH L +VHRD+K N+L+ D + K Sbjct: 481 ITSSTKYTERD---GSAMVYNLANALRYLH---GLSIVHRDIKPENLLVCEYPDGTKSLK 534 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 + DFGLA + +G V GT Y+AP ++ Sbjct: 535 LGDFGLATV-----VEGPLYTVCGTPTYVAPEII 563
>CDC28_YEAST (P00546) Cell division control protein 28 (EC 2.7.11.22)| Length = 298 Score = 60.5 bits (145), Expect = 3e-09 Identities = 48/153 (31%), Positives = 79/153 (51%), Gaps = 3/153 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERL-LVYEFVPNRSL 171 +A+K++ +S +GV E++L+ +LK N+VRL + +L LV+EF+ + L Sbjct: 37 VALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFL-DLDL 95 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + + K + L + Y H +++HRDLK N+L++ D N K+ Sbjct: 96 KRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSH---RILHRDLKPQNLLINKDGNLKL 152 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ ++ T Y AP VL Sbjct: 153 GDFGLARAFG-VPLRAYTHEIV-TLWYRAPEVL 183
>DDR1_MOUSE (Q03146) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protei Length = 911 Score = 60.5 bits (145), Expect = 3e-09 Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 17/163 (10%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +AVK L +T+ + E+ ++++LK N++RL+GVC++ ++ +++ N L+Q Sbjct: 650 VAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQ 709 Query: 178 IL----------------FDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLK 309 L ++++G + + ++YL + L VHRDL Sbjct: 710 FLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYL---ATLNFVHRDLA 766 Query: 310 ASNVLLDADMNPKISDFGLARLFGRGQTQGVTNRVIGTYGYMA 438 N L+ + KI+DFG++R G V R + +MA Sbjct: 767 TRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMA 809
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 60.5 bits (145), Expect = 3e-09 Identities = 38/150 (25%), Positives = 76/150 (50%), Gaps = 3/150 (2%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE---ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +AVK L T+ E + K E + A++ + N+V + V + +V E+V ++L Sbjct: 36 VAVKVLKHEFTEDEEFVFKFKREASAAARIANANIVNIYDVGADGNVNYIVMEYVAGKTL 95 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 +++ + K +++ L + H++ +VHRD+K N+++ D K+ Sbjct: 96 KKLIKENGK---IEFNKIIDYATQIAKALNFAHKNG---IVHRDIKPHNIMVTDDDIIKV 149 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAP 441 +DFG+A+ T TN+V+G+ Y++P Sbjct: 150 TDFGIAKA-SNESTITTTNKVVGSAHYLSP 178
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 60.5 bits (145), Expect = 3e-09 Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 2/127 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQER--LLVYEFVPNRSLD 174 +AVK+L S+ + + + + E+ ++ L+H N+V+ GVC R L+ E++P SL Sbjct: 879 VAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLR 938 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + E++D ++YL + +HRDL N+L++ + KI Sbjct: 939 DYL--QKHKERIDHKKLLQYTSQICKGMEYL---GTKRYIHRDLATRNILVENENRVKIG 993 Query: 355 DFGLARL 375 DFGL ++ Sbjct: 994 DFGLTKV 1000 Score = 44.7 bits (104), Expect = 2e-04 Identities = 37/131 (28%), Positives = 62/131 (47%), Gaps = 8/131 (6%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 + +K L K+ E +++++L HK+LV GVC+ +E +LV EFV SLD Sbjct: 578 VLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTY 637 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADM-----NP 345 L + + W + +L E S ++H ++ A N+LL + NP Sbjct: 638 LKKNKNSINILW--KLGVAKQLAWAMHFLEEKS---LIHGNVCAKNILLIREEDRKTGNP 692 Query: 346 ---KISDFGLA 369 K+SD G++ Sbjct: 693 PFIKLSDPGIS 703
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 60.5 bits (145), Expect = 3e-09 Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 2/127 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQER--LLVYEFVPNRSLD 174 +AVK+L S+ + + + + E+ ++ L+H N+V+ GVC R L+ E++P SL Sbjct: 879 VAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLR 938 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + E++D ++YL + +HRDL N+L++ + KI Sbjct: 939 DYL--QKHKERIDHIKLLQYTSQICKGMEYL---GTKRYIHRDLATRNILVENENRVKIG 993 Query: 355 DFGLARL 375 DFGL ++ Sbjct: 994 DFGLTKV 1000 Score = 45.8 bits (107), Expect = 7e-05 Identities = 41/141 (29%), Positives = 66/141 (46%), Gaps = 18/141 (12%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD-- 174 + +K L K+ E ++++KL HK+LV GVC+ E +LV EFV SLD Sbjct: 578 VLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTY 637 Query: 175 --------QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLD 330 IL+ E +QL W + +L E++ ++H ++ A N+LL Sbjct: 638 LKKNKNCINILWKLEVAKQLAW------------AMHFLEENT---LIHGNVCAKNILLI 682 Query: 331 ADM-----NP---KISDFGLA 369 + NP K+SD G++ Sbjct: 683 REEDRKTGNPPFIKLSDPGIS 703
>KPCD2_HUMAN (Q9BZL6) Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2)| Length = 878 Score = 60.5 bits (145), Expect = 3e-09 Identities = 55/168 (32%), Positives = 84/168 (50%), Gaps = 5/168 (2%) Frame = +1 Query: 1 IAVKRLSKSS--TQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK + K T+ +L+NE+A++ L+H +V L + ++ +V E + L+ Sbjct: 577 VAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLE 636 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL-DADMNP-- 345 IL +EKG +L L++LH + +VH DLK NVLL AD P Sbjct: 637 MIL-SSEKG-RLPERLTKFLITQILVALRHLHFKN---IVHCDLKPENVLLASADPFPQV 691 Query: 346 KISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLREIGMCS 489 K+ DFG AR+ G + V+GT Y+AP VL + R + M S Sbjct: 692 KLCDFGFARIIGE---KSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWS 736
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 60.5 bits (145), Expect = 3e-09 Identities = 42/155 (27%), Positives = 69/155 (44%) Frame = +1 Query: 40 VEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWX 219 V + E ++++L H V+L + ++ + N L + + K D Sbjct: 127 VPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYI---RKIGSFDET 183 Query: 220 XXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQG 399 L+YLH ++HRDLK N+LL+ DM+ +I+DFG A++ Q Sbjct: 184 CTRFYTAEIVSALEYLHGKG---IIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQA 240 Query: 400 VTNRVIGTYGYMAPGVLDARELLREIGMCSASE*W 504 N +GT Y++P ELL E C +S+ W Sbjct: 241 RANSFVGTAQYVSP------ELLTEKSACKSSDLW 269
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 60.1 bits (144), Expect = 3e-09 Identities = 35/126 (27%), Positives = 67/126 (53%), Gaps = 1/126 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L T+ + E ++ + H N++RL GV + + +++ E++ N +LD+ Sbjct: 643 VAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDK 702 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L EK + ++YL + + VHRDL A N+L+++++ K+SD Sbjct: 703 FL--REKDGEFSVLQLVGMLRGIAAGMKYL---ANMNYVHRDLAARNILVNSNLVCKVSD 757 Query: 358 FGLARL 375 FGL+R+ Sbjct: 758 FGLSRV 763
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 60.1 bits (144), Expect = 3e-09 Identities = 46/154 (29%), Positives = 74/154 (48%), Gaps = 5/154 (3%) Frame = +1 Query: 4 AVKRLSKSSTQGVEEL-KNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 A+K + K+ G E L +NE++++ ++KH N++ LV + LV E V L Sbjct: 420 ALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGGDLFDA 479 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL----DADMNPK 348 + + K + D L+YLH L +VHRD+K N+L+ D + K Sbjct: 480 ITSSTKYTERD---GSAMVYNLANALRYLH---SLSIVHRDIKPENLLVCEYPDGTKSLK 533 Query: 349 ISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 + DFGLA + +G V GT Y+AP ++ Sbjct: 534 LGDFGLATV-----VEGPLYTVCGTPTYVAPEII 562
>PAK7_MOUSE (Q8C015) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5) Length = 719 Score = 60.1 bits (144), Expect = 3e-09 Identities = 43/150 (28%), Positives = 69/150 (46%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK++ Q E L NE+ ++ H N+V + L E +V EF+ +L I Sbjct: 475 VAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNSYLVGDELWVVMEFLEGGALTDI 534 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 + T E+ L YLH V+HRD+K+ ++LL +D K+SDF Sbjct: 535 VTHTRMNEE----QIATVCLSVLKALSYLHNQG---VIHRDIKSDSILLTSDGRIKLSDF 587 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 G + + ++GT +MAP V+ Sbjct: 588 GFCAQVSKEVPK--RKSLVGTPYWMAPEVI 615
>PAK7_HUMAN (Q9P286) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (PAK-5) Length = 719 Score = 60.1 bits (144), Expect = 3e-09 Identities = 43/150 (28%), Positives = 69/150 (46%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK++ Q E L NE+ ++ H N+V + L E +V EF+ +L I Sbjct: 475 VAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDI 534 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 + T E+ L YLH V+HRD+K+ ++LL +D K+SDF Sbjct: 535 VTHTRMNEE----QIATVCLSVLRALSYLHNQG---VIHRDIKSDSILLTSDGRIKLSDF 587 Query: 361 GLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 G + + ++GT +MAP V+ Sbjct: 588 GFCAQVSKEVPK--RKSLVGTPYWMAPEVI 615
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 60.1 bits (144), Expect = 3e-09 Identities = 47/152 (30%), Positives = 78/152 (51%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ +S +GV E++L+ +L H N+V L V ++ L++EF+ + L Sbjct: 30 VAMKKIRLESEEEGVPSTAIREISLLKELHHPNIVCLQDVLMQDARLYLIFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ LD + + H +V+HRDLK N+L+D K++ Sbjct: 89 KYLDTIPSGQYLDRSRVKSYLYQILQGIVFCHSR---RVLHRDLKPQNLLIDDKGVIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y +P VL Sbjct: 146 DFGLARAFGI-PVRVYTHEVV-TLWYRSPEVL 175
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 60.1 bits (144), Expect = 3e-09 Identities = 36/136 (26%), Positives = 70/136 (51%), Gaps = 3/136 (2%) Frame = +1 Query: 43 EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXX 222 +++ E ++ K + ++ ++G+C E + +V E++PN SL+++L + + W Sbjct: 61 KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL 120 Query: 223 XXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGV 402 + YLH + ++H DLK N+LLD + + KI+DFGL++ +Q Sbjct: 121 RFRILHEIALGVNYLHNMTP-PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSR 179 Query: 403 TNRVI---GTYGYMAP 441 +++ GT YM P Sbjct: 180 SSKSAPEGGTIIYMPP 195
>CDK2_RAT (Q63699) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 60.1 bits (144), Expect = 3e-09 Identities = 47/152 (30%), Positives = 82/152 (53%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ + T+GV E++L+ +L H N+V+L+ V + + LV+EF+ ++ L Sbjct: 30 VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + + D L L + H +V+HRDLK N+L++A+ + K++ Sbjct: 89 KFM-DASALTGLPLPLIKSYLFQLLQGLAFCHSH---RVLHRDLKPQNLLINAEGSIKLA 144 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y AP +L Sbjct: 145 DFGLARAFG-VPVRTYTHEVV-TLWYRAPEIL 174
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 60.1 bits (144), Expect = 3e-09 Identities = 45/156 (28%), Positives = 74/156 (47%), Gaps = 2/156 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQ--GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK + K+ +++L E+ ++ L H N+V+L V ++ LV E+ + Sbjct: 86 VAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVF 145 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L + ++ + +QY H Q +VHRDLKA N+LLD DMN KI+ Sbjct: 146 DYLVAHGRMKEKE---ARAKFRQIVSAVQYCH---QKYIVHRDLKAENLLLDGDMNIKIA 199 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 DFG + F G + G+ Y AP + ++ Sbjct: 200 DFGFSNEFTVGNK---LDTFCGSPPYAAPELFQGKK 232
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 60.1 bits (144), Expect = 3e-09 Identities = 45/169 (26%), Positives = 80/169 (47%), Gaps = 1/169 (0%) Frame = +1 Query: 1 IAVKRLSKS-STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L S + + +E +++ + H N++RL GV + + +++ EF+ N +LD Sbjct: 649 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDS 708 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L + Q ++YL S++ VHRDL A N+L+++++ K+SD Sbjct: 709 FL--RQNDGQFTVIQLVGMLRGIAAGMKYL---SEMNYVHRDLAARNILVNSNLVCKVSD 763 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLREIGMCSASE*W 504 FGL+R Q + G P A+E + SAS+ W Sbjct: 764 FGLSRYL---QDDTSDPTYTSSLGGKIPVRWTAQEAIAYRKFTSASDVW 809
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 60.1 bits (144), Expect = 3e-09 Identities = 42/125 (33%), Positives = 62/125 (49%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +AVK L + T E A++ K +H LV L VC +++ +V E++ SL Sbjct: 309 VAVKTL-REGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDF 367 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 L + + G L + ++YL E QL +HRDL A NVL+ + KI DF Sbjct: 368 LREGD-GRYLHFEDLIYIATQVASGMEYL-ESKQL--IHRDLAARNVLIGENNVAKICDF 423 Query: 361 GLARL 375 GLAR+ Sbjct: 424 GLARV 428
>RTK2_GEOCY (P42159) Class II receptor tyrosine kinase (EC 2.7.10.1) (GCTK)| Length = 605 Score = 60.1 bits (144), Expect = 3e-09 Identities = 39/133 (29%), Positives = 66/133 (49%), Gaps = 9/133 (6%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEE-LKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +AVK+L ++ V + E+ V++L+H ++V+L+ VC + +V E++ N L+Q Sbjct: 390 VAVKKLKPDVSEEVRQSFDKEIKFVSQLQHDSIVQLLAVCTHSKHPFIVMEYMENGDLNQ 449 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHED--------SQLKVVHRDLKASNVLLDA 333 L +K + +D L Y+ S L VHRDL N L+ + Sbjct: 450 FL---QKYQMVDDDSALYSNQIPPSTLLYMAVQIASGMVYLSSLNYVHRDLATRNCLVGS 506 Query: 334 DMNPKISDFGLAR 372 + KISDFG++R Sbjct: 507 NFRIKISDFGMSR 519
>NTF3_TOBAC (Q40517) Mitogen-activated protein kinase homolog NTF3 (EC| 2.7.11.24) (P43) Length = 372 Score = 60.1 bits (144), Expect = 3e-09 Identities = 49/157 (31%), Positives = 82/157 (52%), Gaps = 7/157 (4%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKN--ELALVAKLKHKNLVRLVGVCLEQQER-----LLVYEFVP 159 +A+K+++ + ++ L+ EL L+ L+H+N++ L V + R LVYE + Sbjct: 58 VAIKKINNAFENRIDALRTLRELKLLRHLRHENVIALKDVMMPIHRRSFKDVYLVYELM- 116 Query: 160 NRSLDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADM 339 + L QI+ + + L L+YLH + ++HRDLK N+L++A+ Sbjct: 117 DTDLHQII---KSSQTLSNDHCQYFLFQLLRGLKYLHSAN---ILHRDLKPGNLLINANC 170 Query: 340 NPKISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 + KI DFGLAR G+ Q +T V+ T Y AP +L Sbjct: 171 DLKICDFGLART-SSGKDQFMTEYVV-TRWYRAPELL 205
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 60.1 bits (144), Expect = 3e-09 Identities = 46/155 (29%), Positives = 75/155 (48%), Gaps = 5/155 (3%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 + V +++K + L+ E+ L+ +L+H N++R +GVC+ Q + + E++ +L+Q+ Sbjct: 77 VMVLKMNKLPSNRSNTLR-EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQL 135 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL---DADMNPKI 351 L E L W L+YLH V HRDL + N L+ D + Sbjct: 136 L---SSPEPLSWPVRLHLALDIAQGLRYLHAKG---VFHRDLTSKNCLVRREDRGFTAVV 189 Query: 352 SDFGLARLFG--RGQTQGVTNRVIGTYGYMAPGVL 450 DFGLA R T+ V+G+ +MAP VL Sbjct: 190 GDFGLAEKIPVYREGTRKEPLAVVGSPYWMAPEVL 224
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 60.1 bits (144), Expect = 3e-09 Identities = 46/153 (30%), Positives = 69/153 (45%), Gaps = 3/153 (1%) Frame = +1 Query: 1 IAVKRLSKSSTQGV---EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSL 171 +A+K + K V E++K E++ + L+H N+V L V + + V E V L Sbjct: 38 VAIKVIDKERILKVGMTEQIKREISAMRLLRHPNIVELHEVMATKSKIYFVMEHVKGGEL 97 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 F+ +L + + H V HRDLK N+LLD N KI Sbjct: 98 ----FNKVSTGKLREDVARKYFQQLVRAVDFCHSRG---VCHRDLKPENLLLDEHGNLKI 150 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 SDFGL+ L + G+ + GT Y+AP V+ Sbjct: 151 SDFGLSALSDSRRQDGLLHTTCGTPAYVAPEVI 183
>CDC28_CANAL (P43063) Cell division control protein 28 (EC 2.7.11.22)| Length = 317 Score = 60.1 bits (144), Expect = 3e-09 Identities = 47/153 (30%), Positives = 81/153 (52%), Gaps = 3/153 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERL-LVYEFVPNRSL 171 +A+K++ +S +GV E++L+ ++K N+VRL + +L LV+EF+ + L Sbjct: 34 VALKKIRLESEDEGVPSTAIREISLLKEMKDDNIVRLYDIIHSDSHKLYLVFEFL-DLDL 92 Query: 172 DQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKI 351 + + +G L +++ H +V+HRDLK N+L+D + N K+ Sbjct: 93 KKYMESIPQGVGLGANMIKRFMNQLIRGIKHCHSH---RVLHRDLKPQNLLIDKEGNLKL 149 Query: 352 SDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 +DFGLAR FG + T+ V+ T Y AP +L Sbjct: 150 ADFGLARAFG-VPLRAYTHEVV-TLWYRAPEIL 180
>DDR1_RAT (Q63474) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein- Length = 910 Score = 60.1 bits (144), Expect = 3e-09 Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 17/163 (10%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +AVK L +T+ + E+ ++++LK N++RL+GVC++ ++ +++ N L+Q Sbjct: 649 VAVKILRPDATKNARNDFLKEVKIMSRLKDLNIIRLLGVCVQDDPLCMITDYMENGDLNQ 708 Query: 178 ILF----------------DTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLK 309 L ++++G + + ++YL + L VHRDL Sbjct: 709 FLSAHQLENKVTQGLPGDRESDQGPTISYPMLLHVGAQIASGMRYL---ATLNFVHRDLA 765 Query: 310 ASNVLLDADMNPKISDFGLARLFGRGQTQGVTNRVIGTYGYMA 438 N L+ + KI+DFG++R G V R + +MA Sbjct: 766 TRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMA 808
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 60.1 bits (144), Expect = 3e-09 Identities = 42/125 (33%), Positives = 65/125 (52%), Gaps = 1/125 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGV-EELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L T+ ++ +E A++ + H N++RL GV + ++V E++ N SLD Sbjct: 663 VAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDA 722 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L T G Q ++YL S L +HRDL A NVL+D + K+SD Sbjct: 723 FL-RTHDG-QFTIVQLVGMLRGVGAGMRYL---SDLGYIHRDLAARNVLVDGRLVCKVSD 777 Query: 358 FGLAR 372 FGL+R Sbjct: 778 FGLSR 782
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 60.1 bits (144), Expect = 3e-09 Identities = 45/151 (29%), Positives = 76/151 (50%), Gaps = 1/151 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K ++ S +G E++L+ +L H+N+V L V + + LV+EF+ ++ L + Sbjct: 34 VALKEINLDSEEGTPSTAIREISLMKELDHENIVTLYDVIHTENKLTLVFEFM-DKDLKK 92 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 + LD + + H++ +V+HRDLK N+L++ K+ D Sbjct: 93 YMEAHGNQGALDLKIVKSFIFQLLKGIMFCHDN---RVLHRDLKPQNLLINNKGELKLGD 149 Query: 358 FGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 FGLAR FG +N V+ T Y AP VL Sbjct: 150 FGLARAFGI-PFNTFSNEVV-TLWYRAPDVL 178
>CDC22_XENLA (P24033) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 2) Length = 302 Score = 60.1 bits (144), Expect = 3e-09 Identities = 45/152 (29%), Positives = 79/152 (51%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ ++ +GV E++L+ +L+H N+V L+ V ++ L++EF+ + + Sbjct: 30 VAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDVLMQDSRLYLIFEFL-SMDVK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + L G+ +D + + H V+HRDLK N+L+D K++ Sbjct: 89 KYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRG---VLHRDLKPQNLLIDNKGVIKLA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y AP VL Sbjct: 146 DFGLARAFGI-PVRVYTHEVV-TLWYRAPEVL 175
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 59.7 bits (143), Expect = 5e-09 Identities = 39/138 (28%), Positives = 68/138 (49%), Gaps = 1/138 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L T+ + E +++ + H N++RL GV + + ++V E++ N SLD Sbjct: 650 VAIKTLKAGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDS 709 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L + Q ++YL S + VHRDL A N+L+++++ K+SD Sbjct: 710 FL--RKHDAQFTVIQLVGMLRGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSD 764 Query: 358 FGLARLFGRGQTQGVTNR 411 FGL+R+ T R Sbjct: 765 FGLSRVLEDDPEAAYTTR 782
>KPCD1_HUMAN (Q15139) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 912 Score = 59.7 bits (143), Expect = 5e-09 Identities = 53/168 (31%), Positives = 83/168 (49%), Gaps = 5/168 (2%) Frame = +1 Query: 1 IAVKRLSKSS--TQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K + K T+ +L+NE+A++ L H +V L + E ER+ V + + Sbjct: 609 VAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECM-FETPERVFVVMEKLHGDML 667 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLL-DADMNP-- 345 +++ +EKG +L L++LH + +VH DLK NVLL AD P Sbjct: 668 EMILSSEKG-RLPEHITKFLITQILVALRHLHFKN---IVHCDLKPENVLLASADPFPQV 723 Query: 346 KISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLREIGMCS 489 K+ DFG AR+ G + V+GT Y+AP VL + R + M S Sbjct: 724 KLCDFGFARIIGE---KSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWS 768
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 59.7 bits (143), Expect = 5e-09 Identities = 36/125 (28%), Positives = 67/125 (53%), Gaps = 1/125 (0%) Frame = +1 Query: 1 IAVKRLSKS-STQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L S + + +E +++ + H N++RL GV + + +++ EF+ N +LD Sbjct: 648 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDS 707 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L + Q ++YL S++ VHRDL A N+L+++++ K+SD Sbjct: 708 FL--RQNDGQFTVIQLVGMLRGIAAGMKYL---SEMNYVHRDLAARNILVNSNLVCKVSD 762 Query: 358 FGLAR 372 FGL+R Sbjct: 763 FGLSR 767
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 59.7 bits (143), Expect = 5e-09 Identities = 43/152 (28%), Positives = 75/152 (49%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLSKSST--QGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK L+ ++ Q ++ KNE+ ++ K +H N++ +G + Q +V ++ SL Sbjct: 520 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLY 578 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L E + + + YLH S ++HRDLK++N+ L D+ KI Sbjct: 579 HHLHIIET--KFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIG 633 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLA + R ++ G+ +MAP V+ Sbjct: 634 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 665
>MARK3_HUMAN (P27448) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10) Length = 776 Score = 59.7 bits (143), Expect = 5e-09 Identities = 47/176 (26%), Positives = 79/176 (44%), Gaps = 22/176 (12%) Frame = +1 Query: 1 IAVKRLSKSSTQ--GVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K + K+ +++L E+ ++ L H N+V+L V ++ L+ E+ + Sbjct: 82 VAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVF 141 Query: 175 QILF----------------DTEKGE----QLDWXXXXXXXXXXXXXLQYLHEDSQLKVV 294 L + G+ Q+ + +QY H Q ++V Sbjct: 142 DYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCH---QKRIV 198 Query: 295 HRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVTNRVIGTYGYMAPGVLDARE 462 HRDLKA N+LLDADMN KI+DFG + F G G + G+ Y AP + ++ Sbjct: 199 HRDLKAENLLLDADMNIKIADFGFSNEFTVG---GKLDTFCGSPPYAAPELFQGKK 251
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 59.7 bits (143), Expect = 5e-09 Identities = 46/152 (30%), Positives = 82/152 (53%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ + T+GV E++L+ +L H N+V+L+ V + + LV+EF+ ++ L Sbjct: 30 VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + + D + L + H +V+HRDLK N+L++A+ + K++ Sbjct: 89 KFM-DASAVTGIPLPLIKSYLFQLLQGLAFCHSH---RVLHRDLKPQNLLINAEGSIKLA 144 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y AP +L Sbjct: 145 DFGLARAFG-VPVRTYTHEVV-TLWYRAPEIL 174
>CDC2_DROME (P23572) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 297 Score = 59.7 bits (143), Expect = 5e-09 Identities = 44/152 (28%), Positives = 80/152 (52%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ +S +GV E++L+ +LKH+N+V L V +E+ L++EF+ + L Sbjct: 30 VAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEENRIYLIFEFL-SMDLK 88 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 + + + ++ + + H + +V+HRDLK N+L+D K++ Sbjct: 89 KYMDSLPVDKHMESELVRSYLYQITSAILFCH---RRRVLHRDLKPQNLLIDKSGLIKVA 145 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGL R FG + T+ ++ T Y AP VL Sbjct: 146 DFGLGRSFGI-PVRIYTHEIV-TLWYRAPEVL 175
>CDC2H_PLACH (Q4Y4B1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 59.7 bits (143), Expect = 5e-09 Identities = 41/131 (31%), Positives = 73/131 (55%) Frame = +1 Query: 58 ELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXX 237 E++++ +L+H N+V+L V ++ +LV+E + ++ L +++ + G L+ Sbjct: 50 EISILKELRHSNIVKLYDVIHAKKRLILVFEHL-DQDLKKLIDVCDGG--LESVTAKSFL 106 Query: 238 XXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVTNRVI 417 + Y HE +V+HRDLK N+L++ + KI+DFGLAR FG + T+ V+ Sbjct: 107 LQLLNGIAYCHEH---RVLHRDLKPQNLLINREGELKIADFGLARAFGI-PARRYTHEVV 162 Query: 418 GTYGYMAPGVL 450 T Y AP +L Sbjct: 163 -TLWYRAPDIL 172
>CDC2H_PLABA (Q4Z6R1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 59.7 bits (143), Expect = 5e-09 Identities = 41/131 (31%), Positives = 73/131 (55%) Frame = +1 Query: 58 ELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXX 237 E++++ +L+H N+V+L V ++ +LV+E + ++ L +++ + G L+ Sbjct: 50 EISILKELRHSNIVKLYDVIHAKKRLILVFEHL-DQDLKKLIDVCDGG--LESVTAKSFL 106 Query: 238 XXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVTNRVI 417 + Y HE +V+HRDLK N+L++ + KI+DFGLAR FG + T+ V+ Sbjct: 107 LQLLNGIAYCHEH---RVLHRDLKPQNLLINREGELKIADFGLARAFGI-PARRYTHEVV 162 Query: 418 GTYGYMAPGVL 450 T Y AP +L Sbjct: 163 -TLWYRAPDIL 172
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 59.7 bits (143), Expect = 5e-09 Identities = 43/152 (28%), Positives = 75/152 (49%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLSKSST--QGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK L+ ++ Q ++ KNE+ ++ K +H N++ +G + Q +V ++ SL Sbjct: 480 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLY 538 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L E + + + YLH S ++HRDLK++N+ L D+ KI Sbjct: 539 HHLHIIET--KFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIG 593 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLA + R ++ G+ +MAP V+ Sbjct: 594 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 625
>CDK2_MOUSE (P97377) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 346 Score = 59.7 bits (143), Expect = 5e-09 Identities = 49/152 (32%), Positives = 78/152 (51%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLS-KSSTQGVEELK-NELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +A+K++ + T+GV E++L+ +L H N+V+L+ V + + LV+EF L Sbjct: 30 VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEF-----LH 84 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 Q L L LQ L +V+HRDLK N+L++A+ + K++ Sbjct: 85 QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLA 144 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLAR FG + T+ V+ T Y AP +L Sbjct: 145 DFGLARAFG-VPVRTYTHEVV-TLWYRAPEIL 174
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 59.7 bits (143), Expect = 5e-09 Identities = 43/147 (29%), Positives = 72/147 (48%), Gaps = 15/147 (10%) Frame = +1 Query: 52 KNELALVAKLKHKNLVRLVGVCLE--QQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXX 225 +NE+ +++KL+H N+V+ +G C + +V E++ SL Q L D + + Sbjct: 1333 QNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPHIR 1392 Query: 226 XXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNP-------------KISDFGL 366 + YLH + ++HRDL + N+LLD +++P KISDFGL Sbjct: 1393 LKLALDIAKGMNYLHGWTP-PILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGL 1451 Query: 367 ARLFGRGQTQGVTNRVIGTYGYMAPGV 447 +RL + + + +G YMAP V Sbjct: 1452 SRL--KKEQASQMTQSVGCIPYMAPEV 1476
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 59.7 bits (143), Expect = 5e-09 Identities = 43/152 (28%), Positives = 75/152 (49%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLSKSST--QGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK L+ ++ Q ++ KNE+ ++ K +H N++ +G + Q +V ++ SL Sbjct: 90 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLY 148 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L E + + + YLH S ++HRDLK++N+ L D+ KI Sbjct: 149 HHLHIIET--KFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIG 203 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLA + R ++ G+ +MAP V+ Sbjct: 204 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 235
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 59.7 bits (143), Expect = 5e-09 Identities = 45/172 (26%), Positives = 80/172 (46%), Gaps = 4/172 (2%) Frame = +1 Query: 1 IAVKRLSKSST-QGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L T Q + E +++ + H N++RL GV + +++ EF+ N +LD Sbjct: 638 VAIKTLKAGYTEQQRRDFLGEASIMGQFDHPNIIRLEGVVTRSRPVMILTEFMENGALDS 697 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L + Q ++YL S++ VHRDL A N+L+++++ K+SD Sbjct: 698 FLRMNDG--QFTVIQLVGILRGIASGMKYL---SEMNYVHRDLAARNILVNSNLVCKVSD 752 Query: 358 FGLARLFGRGQTQGVTNRVIG---TYGYMAPGVLDARELLREIGMCSASE*W 504 FGL+R ++ +G + AP + R+ SAS+ W Sbjct: 753 FGLSRFLENSRSDPTYTSALGGKIPIRWTAPEAISYRK------FTSASDVW 798
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 59.7 bits (143), Expect = 5e-09 Identities = 43/152 (28%), Positives = 75/152 (49%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLSKSST--QGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK L+ ++ Q ++ KNE+ ++ K +H N++ +G + Q +V ++ SL Sbjct: 520 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLY 578 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L E + + + YLH S ++HRDLK++N+ L D+ KI Sbjct: 579 HHLHIIET--KFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIG 633 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLA + R ++ G+ +MAP V+ Sbjct: 634 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 665
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 59.7 bits (143), Expect = 5e-09 Identities = 43/152 (28%), Positives = 75/152 (49%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLSKSST--QGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK L+ ++ Q ++ KNE+ ++ K +H N++ +G + Q +V ++ SL Sbjct: 106 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLY 164 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L E + + + YLH S ++HRDLK++N+ L D+ KI Sbjct: 165 HHLHIIET--KFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIG 219 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLA + R ++ G+ +MAP V+ Sbjct: 220 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 251
>CDC2H_PLAYO (Q7RM49) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 289 Score = 59.7 bits (143), Expect = 5e-09 Identities = 41/131 (31%), Positives = 73/131 (55%) Frame = +1 Query: 58 ELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFDTEKGEQLDWXXXXXXX 237 E++++ +L+H N+V+L V ++ +LV+E + ++ L +++ + G L+ Sbjct: 51 EISILKELRHSNIVKLYDVIHAKKRLILVFEHL-DQDLKKLIDVCDGG--LESVTAKSFL 107 Query: 238 XXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLARLFGRGQTQGVTNRVI 417 + Y HE +V+HRDLK N+L++ + KI+DFGLAR FG + T+ V+ Sbjct: 108 LQLLNGIAYCHEH---RVLHRDLKPQNLLINREGELKIADFGLARAFGI-PARRYTHEVV 163 Query: 418 GTYGYMAPGVL 450 T Y AP +L Sbjct: 164 -TLWYRAPDIL 173
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 59.7 bits (143), Expect = 5e-09 Identities = 43/152 (28%), Positives = 75/152 (49%), Gaps = 2/152 (1%) Frame = +1 Query: 1 IAVKRLSKSST--QGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLD 174 +AVK L+ ++ Q ++ KNE+ ++ K +H N++ +G + Q +V ++ SL Sbjct: 42 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLY 100 Query: 175 QILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKIS 354 L E + + + YLH S ++HRDLK++N+ L D+ KI Sbjct: 101 HHLHIIET--KFEMIKLIDIARQTAQGMDYLHAKS---IIHRDLKSNNIFLHEDLTVKIG 155 Query: 355 DFGLARLFGRGQTQGVTNRVIGTYGYMAPGVL 450 DFGLA + R ++ G+ +MAP V+ Sbjct: 156 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 187
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 59.3 bits (142), Expect = 6e-09 Identities = 41/124 (33%), Positives = 61/124 (49%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQI 180 +A+K +++ S E+ E ++ KL H LV+L GVC++Q+ +V EF+ N L Sbjct: 296 VAIKAINEGS-MSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDY 354 Query: 181 LFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDF 360 L E+ QL + YL +HRDL A N L+ + KISDF Sbjct: 355 L--RERKGQLQKALLLSMCQDICEGMAYLERSC---YIHRDLAARNCLVSSACVVKISDF 409 Query: 361 GLAR 372 G+AR Sbjct: 410 GMAR 413
>HUNK_PANTR (Q68UT7) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) Length = 714 Score = 59.3 bits (142), Expect = 6e-09 Identities = 40/147 (27%), Positives = 69/147 (46%) Frame = +1 Query: 10 KRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFD 189 K+ +K T + L+ E + ++H N+ +L+ + + LV E P +L +++ Sbjct: 95 KKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYE 154 Query: 190 TEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLA 369 ++ E+ + +++LH VVHRDLK N+LLD D N K+ DFGL+ Sbjct: 155 KKRLEESE---ARRYIRQLISAVEHLHRAG---VVHRDLKIENLLLDEDNNIKLIDFGLS 208 Query: 370 RLFGRGQTQGVTNRVIGTYGYMAPGVL 450 G + G+ Y AP +L Sbjct: 209 NCAGILGYSDPFSTQCGSPAYAAPELL 235
>HUNK_HUMAN (P57058) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19) Length = 714 Score = 59.3 bits (142), Expect = 6e-09 Identities = 40/147 (27%), Positives = 69/147 (46%) Frame = +1 Query: 10 KRLSKSSTQGVEELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQILFD 189 K+ +K T + L+ E + ++H N+ +L+ + + LV E P +L +++ Sbjct: 95 KKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYE 154 Query: 190 TEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISDFGLA 369 ++ E+ + +++LH VVHRDLK N+LLD D N K+ DFGL+ Sbjct: 155 KKRLEESE---ARRYIRQLISAVEHLHRAG---VVHRDLKIENLLLDEDNNIKLIDFGLS 208 Query: 370 RLFGRGQTQGVTNRVIGTYGYMAPGVL 450 G + G+ Y AP +L Sbjct: 209 NCAGILGYSDPFSTQCGSPAYAAPELL 235
>BMPR2_HUMAN (Q13873) Bone morphogenetic protein receptor type-2 precursor (EC| 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) Length = 1038 Score = 59.3 bits (142), Expect = 6e-09 Identities = 56/175 (32%), Positives = 77/175 (44%), Gaps = 17/175 (9%) Frame = +1 Query: 1 IAVKRLSKSSTQGVEELKNELALVAKLKHKNLVR-LVG----VCLEQQERLLVYEFVPNR 165 +AVK S ++ Q KN + V ++H N+ R +VG + E LLV E+ PN Sbjct: 227 VAVKVFSFANRQNFINEKN-IYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNG 285 Query: 166 SLDQILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDS------QLKVVHRDLKASNVLL 327 SL + L DW L YLH + + + HRDL + NVL+ Sbjct: 286 SLCKYL----SLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLV 341 Query: 328 DADMNPKISDFGLA------RLFGRGQTQGVTNRVIGTYGYMAPGVLDARELLRE 474 D ISDFGL+ RL G+ +GT YMAP VL+ LR+ Sbjct: 342 KNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRD 396
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 59.3 bits (142), Expect = 6e-09 Identities = 39/138 (28%), Positives = 68/138 (49%), Gaps = 1/138 (0%) Frame = +1 Query: 1 IAVKRLSKSSTQGVE-ELKNELALVAKLKHKNLVRLVGVCLEQQERLLVYEFVPNRSLDQ 177 +A+K L T+ + E +++ + H N++RL GV + + ++V E++ N SLD Sbjct: 650 VAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDS 709 Query: 178 ILFDTEKGEQLDWXXXXXXXXXXXXXLQYLHEDSQLKVVHRDLKASNVLLDADMNPKISD 357 L + Q ++YL S + VHRDL A N+L+++++ K+SD Sbjct: 710 FL--RKHDAQFTVIQLVGMLRGIASGMKYL---SDMGYVHRDLAARNILINSNLVCKVSD 764 Query: 358 FGLARLFGRGQTQGVTNR 411 FGL+R+ T R Sbjct: 765 FGLSRVLEDDPEAAYTTR 782 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 65,475,652 Number of Sequences: 219361 Number of extensions: 1334256 Number of successful extensions: 8556 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6792 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7650 length of database: 80,573,946 effective HSP length: 104 effective length of database: 57,760,402 effective search space used: 3812186532 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
