ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | baak4i11 |
|---|---|
| Clone Library Name | barley_pub |
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 244 bits (623), Expect = 1e-64 Identities = 117/180 (65%), Positives = 147/180 (81%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GTF KV+ AR L++ SVAIK++DKE++LKVG++EQI+RE++ MRL+ H NIV+LHEVM Sbjct: 20 QGTFAKVYHARHLKTGDSVAIKVIDKERILKVGMTEQIKREISAMRLLRHPNIVELHEVM 79 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 AT++KIYFVME+VKGGELF+KV+ +GKL E A KYFQQL+ AVD+CHS+GV HR Sbjct: 80 ATKSKIYFVMEHVKGGELFNKVS-TGKLREDVARKYFQQLVRAVDFCHSRGVCHRDLKPE 138 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 +SDFGLSALS+S+RQDGLLHTTCGTPAYVAPEVIS+ GYDG K+D+WSC Sbjct: 139 NLLLDEHGNLKISDFGLSALSDSRRQDGLLHTTCGTPAYVAPEVISRNGYDGFKADVWSC 198
>CIPK1_ORYSA (Q6X4A2) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1)| Length = 449 Score = 223 bits (569), Expect = 2e-58 Identities = 110/180 (61%), Positives = 134/180 (74%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EGTF KV FA++ E+++ VAIK+LDKEKV K L EQIRRE+ TM+LV H N+V+L EVM Sbjct: 28 EGTFAKVRFAKNTENDEPVAIKILDKEKVQKHRLVEQIRREICTMKLVKHPNVVRLFEVM 87 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++ +I+ V+EYV GGELF+ +A +G+L E A KYFQQLI+AVDYCHS+GVYHR Sbjct: 88 GSKARIFIVLEYVTGGELFEIIATNGRLKEEEARKYFQQLINAVDYCHSRGVYHRDLKLE 147 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 VSDFGLSAL+E + DGLLHTTCGTP YVAPEVI GYDGA +DIWSC Sbjct: 148 NLLLDASGNLKVSDFGLSALTEQVKADGLLHTTCGTPNYVAPEVIEDRGYDGAAADIWSC 207
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 214 bits (545), Expect = 1e-55 Identities = 103/180 (57%), Positives = 135/180 (75%), Gaps = 1/180 (0%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVL-KVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 G F KV AR + QSVA+K+L+K+K+L L+ I+RE++ MR ++H NIV+LHEVM Sbjct: 30 GAFAKVFHARDRRTGQSVAVKILNKKKLLTNPALANNIKREISIMRRLSHPNIVKLHEVM 89 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 AT++KI+F ME+VKGGELF+K++K G+L+E + +YFQQLISAV YCH++GVYHR Sbjct: 90 ATKSKIFFAMEFVKGGELFNKISKHGRLSEDLSRRYFQQLISAVGYCHARGVYHRDLKPE 149 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 VSDFGLSAL++ R DGLLHT CGTPAYVAPE++SK GY+GAK D+WSC Sbjct: 150 NLLIDENGNLKVSDFGLSALTDQIRPDGLLHTLCGTPAYVAPEILSKKGYEGAKVDVWSC 209
>CIPK1_ARATH (Q8RWC9) CBL-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (SOS2-like protein kinase PKS13) (SNF1-related kinase 3.16) Length = 444 Score = 201 bits (511), Expect = 1e-51 Identities = 94/180 (52%), Positives = 124/180 (68%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG FGKV FA+ S S A+K++DK ++ + S QI+RE+ T++++ H +IV+LHEV+ Sbjct: 28 EGNFGKVKFAKDTVSGHSFAVKIIDKSRIADLNFSLQIKREIRTLKMLKHPHIVRLHEVL 87 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 A++ KI VME V GGELFD++ +GKLTE K FQQLI + YCHS+GV+HR Sbjct: 88 ASKTKINMVMELVTGGELFDRIVSNGKLTETDGRKMFQQLIDGISYCHSKGVFHRDLKLE 147 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFGLSAL + R DGLLHTTCG+P YVAPEV++ GYDGA SDIWSC Sbjct: 148 NVLLDAKGHIKITDFGLSALPQHFRDDGLLHTTCGSPNYVAPEVLANRGYDGAASDIWSC 207
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 190 bits (483), Expect = 2e-48 Identities = 93/180 (51%), Positives = 126/180 (70%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EGTF KV FAR+ ++ +VAIK++ K +LK + +QI+RE++ M++V H NIV+L+EV+ Sbjct: 19 EGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYEVL 78 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 A+ +KIY V+E+V GGELFD++ G+L E + KYFQQL+ AV +CH +GVYHR Sbjct: 79 ASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPE 138 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 VSDFGLSAL + + LL TTCGTP YVAPEV+S GYDG+ +DIWSC Sbjct: 139 NLLLDTNGNLKVSDFGLSALPQEGVE--LLRTTCGTPNYVAPEVLSGQGYDGSAADIWSC 196
>KIN11_ARATH (P92958) SNF1-related protein kinase catalytic alpha subunit KIN11| (EC 2.7.11.1) (AKIN11) (AKIN alpha1) Length = 512 Score = 151 bits (382), Expect = 1e-36 Identities = 76/179 (42%), Positives = 108/179 (60%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FGKV A + + VAIK+L++ K+ + + E++RRE+ +RL H +I++ +EV+ Sbjct: 29 GSFGKVKIAEHVVTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPHIIRQYEVIE 88 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + IY VMEYVK GELFD + + G+L E A +FQQ+IS V+YCH V HR Sbjct: 89 TTSDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPEN 148 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFGLS + R L T+CG+P Y APEVIS Y G + D+WSC Sbjct: 149 LLLDSRCNIKIADFGLSNV---MRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSC 204
>KIN10_ARATH (Q38997) SNF1-related protein kinase catalytic alpha subunit KIN10| (EC 2.7.11.1) (AKIN10) (AKIN alpha2) Length = 535 Score = 149 bits (377), Expect = 4e-36 Identities = 75/179 (41%), Positives = 106/179 (59%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V A + VAIK+L++ K+ + + E++RRE+ +RL H +I++L+EV+ Sbjct: 51 GSFGRVKIAEHALTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPHIIRLYEVIE 110 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T IY VMEYV GELFD + + G+L E A +FQQ+IS V+YCH V HR Sbjct: 111 TPTDIYLVMEYVNSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPEN 170 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFGLS + R L T+CG+P Y APEVIS Y G + D+WSC Sbjct: 171 LLLDSKCNVKIADFGLSNI---MRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSC 226
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 145 bits (367), Expect = 6e-35 Identities = 74/180 (41%), Positives = 108/180 (60%), Gaps = 1/180 (0%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 GTFGKV + VA+K+L+++K+ + + +I+RE+ ++L H +I++L++V++ Sbjct: 25 GTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVIS 84 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEYV GGELFD + K G++ E A + FQQ++SAVDYCH V HR Sbjct: 85 TPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPEN 144 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFGLS + DG L T+CG+P Y APEVIS Y G + DIWSC Sbjct: 145 VLLDAQMNAKIADFGLS----NMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 145 bits (367), Expect = 6e-35 Identities = 74/180 (41%), Positives = 108/180 (60%), Gaps = 1/180 (0%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 GTFGKV + VA+K+L+++K+ + + +I+RE+ ++L H +I++L++V++ Sbjct: 25 GTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVIS 84 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEYV GGELFD + K G++ E A + FQQ++SAVDYCH V HR Sbjct: 85 TPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPEN 144 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFGLS + DG L T+CG+P Y APEVIS Y G + DIWSC Sbjct: 145 VLLDAHMNAKIADFGLSNI----MSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 145 bits (367), Expect = 6e-35 Identities = 74/180 (41%), Positives = 108/180 (60%), Gaps = 1/180 (0%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 GTFGKV + VA+K+L+++K+ + + +I+RE+ ++L H +I++L++V++ Sbjct: 25 GTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVIS 84 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEYV GGELFD + K G++ E A + FQQ++SAVDYCH V HR Sbjct: 85 TPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPEN 144 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFGLS + DG L T+CG+P Y APEVIS Y G + DIWSC Sbjct: 145 VLLDAQMNAKIADFGLS----NMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 145 bits (367), Expect = 6e-35 Identities = 74/180 (41%), Positives = 108/180 (60%), Gaps = 1/180 (0%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 GTFGKV + VA+K+L+++K+ + + +I+RE+ ++L H +I++L++V++ Sbjct: 25 GTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVIS 84 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEYV GGELFD + K G++ E A + FQQ++SAVDYCH V HR Sbjct: 85 TPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPEN 144 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFGLS + DG L T+CG+P Y APEVIS Y G + DIWSC Sbjct: 145 VLLDAHMNAKIADFGLS----NMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 145 bits (365), Expect = 1e-34 Identities = 74/179 (41%), Positives = 110/179 (61%), Gaps = 1/179 (0%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 GTFGKV + + VA+K+L+++K+ + + +IRRE+ ++L H +I++L++V++ Sbjct: 27 GTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVIS 86 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + I+ VMEYV GGELFD + K+G+L E + + FQQ++S VDYCH V HR Sbjct: 87 TPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPEN 146 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGLS + DG L T+CG+P Y APEVIS Y G + DIWS Sbjct: 147 VLLDAHMNAKIADFGLS----NMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 201
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 145 bits (365), Expect = 1e-34 Identities = 74/179 (41%), Positives = 110/179 (61%), Gaps = 1/179 (0%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 GTFGKV + + VA+K+L+++K+ + + +IRRE+ ++L H +I++L++V++ Sbjct: 27 GTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVIS 86 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + I+ VMEYV GGELFD + K+G+L E + + FQQ++S VDYCH V HR Sbjct: 87 TPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPEN 146 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGLS + DG L T+CG+P Y APEVIS Y G + DIWS Sbjct: 147 VLLDAHMNAKIADFGLS----NMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 201
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 145 bits (365), Expect = 1e-34 Identities = 74/179 (41%), Positives = 110/179 (61%), Gaps = 1/179 (0%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 GTFGKV + + VA+K+L+++K+ + + +IRRE+ ++L H +I++L++V++ Sbjct: 25 GTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVIS 84 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + I+ VMEYV GGELFD + K+G+L E + + FQQ++S VDYCH V HR Sbjct: 85 TPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPEN 144 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGLS + DG L T+CG+P Y APEVIS Y G + DIWS Sbjct: 145 VLLDAHMNAKIADFGLS----NMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 145 bits (365), Expect = 1e-34 Identities = 74/179 (41%), Positives = 110/179 (61%), Gaps = 1/179 (0%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 GTFGKV + + VA+K+L+++K+ + + +IRRE+ ++L H +I++L++V++ Sbjct: 25 GTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVIS 84 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + I+ VMEYV GGELFD + K+G+L E + + FQQ++S VDYCH V HR Sbjct: 85 TPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPEN 144 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGLS + DG L T+CG+P Y APEVIS Y G + DIWS Sbjct: 145 VLLDAHMNAKIADFGLS----NMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199
>AAPK2_CAEEL (Q95ZQ4) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMP-activated kinase 2) Length = 626 Score = 143 bits (360), Expect = 4e-34 Identities = 73/180 (40%), Positives = 108/180 (60%), Gaps = 1/180 (0%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 GTFGKV + VA+K+L+++K+ + + +IRRE+ + L H +I++L++V++ Sbjct: 96 GTFGKVKVGIHETTQYKVAVKILNRQKIKSLDVVGKIRREIQNLSLFRHPHIIRLYQVIS 155 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + I+ +ME+V GGELFD + K G+L A ++FQQ+IS VDYCH V HR Sbjct: 156 TPSDIFMIMEHVSGGELFDYIVKHGRLKTAEARRFFQQIISGVDYCHRHMVVHRDLKPEN 215 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFGLS + DG L T+CG+P Y APEVIS Y G + D+WSC Sbjct: 216 LLLDEQNNVKIADFGLSNI----MTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSC 271
>BRSK2_HUMAN (Q8IWQ3) BR serine/threonine-protein kinase 2 (EC 2.7.11.1)| (Serine/threonine-protein kinase 29) (SAD1B) Length = 736 Score = 141 bits (356), Expect = 1e-33 Identities = 69/180 (38%), Positives = 108/180 (60%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G G V + Q VAIK++++EK L + ++ RE+ ++L+ H ++++LH+V Sbjct: 27 KGQTGLVKLGVHCVTCQKVAIKIVNREK-LSESVLMKVEREIAILKLIEHPHVLKLHDVY 85 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 + +Y V+E+V GGELFD + K G+LT A K+F+Q+ISA+D+CHS + HR Sbjct: 86 ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPE 145 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFG+++L D LL T+CG+P Y PEVI YDG K+D+WSC Sbjct: 146 NLLLDEKNNIRIADFGMASLQVG---DSLLETSCGSPHYACPEVIRGEKYDGRKADVWSC 202
>BRSK1_HUMAN (Q8TDC3) BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1| kinase) (SAD1A) Length = 794 Score = 140 bits (352), Expect = 3e-33 Identities = 67/180 (37%), Positives = 108/180 (60%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G G V + Q VAIK++++EK L + ++ RE+ ++L+ H ++++LH+V Sbjct: 58 KGQTGLVKLGVHCITGQKVAIKIVNREK-LSESVLMKVEREIAILKLIEHPHVLKLHDVY 116 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 + +Y V+E+V GGELFD + K G+LT A K+F+Q++SA+D+CHS + HR Sbjct: 117 ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPE 176 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFG+++L D LL T+CG+P Y PEVI YDG ++D+WSC Sbjct: 177 NLLLDEKNNIRIADFGMASLQVG---DSLLETSCGSPHYACPEVIKGEKYDGRRADMWSC 233
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 138 bits (348), Expect = 9e-33 Identities = 69/180 (38%), Positives = 111/180 (61%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG+FGKV A + + Q VA+K+++K+ + K + +I RE++ +RL+ H +I++L++V+ Sbjct: 47 EGSFGKVKLAYHVTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVI 106 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++++I V+EY G ELFD + + K++E A ++FQQ+ISAV+YCH + HR Sbjct: 107 KSKDEIIMVIEYA-GNELFDYIVQRNKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPE 165 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFGLS + L T+CG+P Y APEVIS Y G + D+WSC Sbjct: 166 NLLLDEHLNVKIADFGLSNI---MTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSC 222
>SNF1_YEAST (P06782) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 633 Score = 137 bits (345), Expect = 2e-32 Identities = 69/180 (38%), Positives = 110/180 (61%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG+FGKV A + Q VA+K+++K+ + K + +I RE++ +RL+ H +I++L++V+ Sbjct: 63 EGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVI 122 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++++I V+EY G ELFD + + K++E A ++FQQ+ISAV+YCH + HR Sbjct: 123 KSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPE 181 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFGLS + L T+CG+P Y APEVIS Y G + D+WSC Sbjct: 182 NLLLDEHLNVKIADFGLSNI---MTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSC 238
>SN1L2_HUMAN (Q9H0K1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 926 Score = 134 bits (337), Expect = 2e-31 Identities = 74/184 (40%), Positives = 106/184 (57%), Gaps = 5/184 (2%) Frame = +3 Query: 9 EGTFGKVHFA-----RSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQ 173 EGT GK +FA R + VAIK++DK ++ V L E+I REV M+++ H +I++ Sbjct: 23 EGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNL-EKIYREVQIMKMLDHPHIIK 81 Query: 174 LHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR 353 L++VM T++ +Y V EY K GE+FD +A G+L E A + F Q++SAVDYCH + + HR Sbjct: 82 LYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHR 141 Query: 354 XXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKS 533 ++DFG +S LL T CG+P Y APEV Y+G + Sbjct: 142 DLKAENLLLDNNMNIKIADFGFGNFFKSGE---LLATWCGSPPYAAPEVFEGQQYEGPQL 198 Query: 534 DIWS 545 DIWS Sbjct: 199 DIWS 202
>SN1L2_MOUSE (Q8CFH6) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Salt-inducible kinase 2) Length = 931 Score = 134 bits (337), Expect = 2e-31 Identities = 74/184 (40%), Positives = 106/184 (57%), Gaps = 5/184 (2%) Frame = +3 Query: 9 EGTFGKVHFA-----RSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQ 173 EGT GK +FA R + VAIK++DK ++ V L E+I REV M+++ H +I++ Sbjct: 23 EGTLGKGNFAVVKLGRHRTTKTEVAIKIIDKSQLDAVNL-EKIYREVQIMKMLDHPHIIK 81 Query: 174 LHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR 353 L++VM T++ +Y V EY K GE+FD +A G+L E A + F Q++SAVDYCH + V HR Sbjct: 82 LYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKVVHR 141 Query: 354 XXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKS 533 ++DFG ++ LL T CG+P Y APEV Y+G + Sbjct: 142 DLKAENLLLDNNMNIKIADFGFGNFFKTGE---LLATWCGSPPYAAPEVFEGQQYEGPQL 198 Query: 534 DIWS 545 DIWS Sbjct: 199 DIWS 202
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 133 bits (334), Expect = 4e-31 Identities = 65/179 (36%), Positives = 111/179 (62%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG+FGKV A+ + + Q VA+K+++++ + K + ++ RE++ +RL+ H +I++L++V+ Sbjct: 60 EGSFGKVKLAQHVGTGQKVALKIINRKTLAKSDMQGRVEREISYLRLLRHPHIIKLYDVI 119 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++++I V+E+ G ELFD + + GK+ E A ++FQQ+I+AV+YCH + HR Sbjct: 120 KSKDEIIMVIEFA-GKELFDYIVQRGKMPEDEARRFFQQIIAAVEYCHRHKIVHRDLKPE 178 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGLS + L T+CG+P Y APEVIS Y G + D+WS Sbjct: 179 NLLLDDQLNVKIADFGLSNI---MTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWS 234
>SNF1_SCHPO (O74536) SNF1-like protein kinase ssp2 (EC 2.7.11.1)| Length = 576 Score = 132 bits (331), Expect = 8e-31 Identities = 64/180 (35%), Positives = 105/180 (58%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG+FGKV A ++ Q VA+K + ++ + K + ++ RE++ ++L+ H +I++L++V+ Sbjct: 42 EGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYDVI 101 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T I V+EY GGELFD + + ++TE ++FQQ+I A++YCH + HR Sbjct: 102 TTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIVHRDLKPE 160 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 ++DFGLS + L T+CG+P Y APEVI+ Y G + D+WSC Sbjct: 161 NLLLDDNLNVKIADFGLSNI---MTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWSC 217
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 130 bits (326), Expect = 3e-30 Identities = 66/180 (36%), Positives = 112/180 (62%), Gaps = 1/180 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG+FGKV A+ L + Q VA+K+++++ + K + ++ RE++ +RL+ H +I++L++V+ Sbjct: 61 EGSFGKVKLAQHLGTGQKVALKIINRKTLAKSDMQGRVEREISYLRLLRHPHIIKLYDVI 120 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++++I V+E+ G ELFD + + GK+ E A ++FQQ+I+AV+YCH + HR Sbjct: 121 KSKDEIIMVIEFA-GKELFDYIVQRGKMPEDEARRFFQQIIAAVEYCHRHKIVHRDLKPE 179 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYV-APEVISKTGYDGAKSDIWS 545 ++DFGLS + L T+CG+P Y+ APEVIS Y G + D+WS Sbjct: 180 NLLLDDQLNVKIADFGLSNI---MTDGNFLKTSCGSPNYMPAPEVISGKLYAGPEVDVWS 236
>MARK3_MOUSE (Q03141) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (MPK-10) (ELKL motif kinase 2) Length = 753 Score = 128 bits (322), Expect = 9e-30 Identities = 66/179 (36%), Positives = 99/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F KV AR + + + VAIK++DK ++ L +++ REV M+++ H NIV+L EV+ Sbjct: 64 KGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL-QKLFREVRIMKILNHPNIVKLFEVI 122 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +Y +MEY GGE+FD + G++ E A F+Q++SAV YCH + + HR Sbjct: 123 ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAE 182 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S L T CG+P Y APE+ YDG + D+WS Sbjct: 183 NLLLDADMNIKIADFG---FSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 238
>MARK3_RAT (Q8VHF0) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| Length = 797 Score = 128 bits (322), Expect = 9e-30 Identities = 66/179 (36%), Positives = 99/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F KV AR + + + VAIK++DK ++ L +++ REV M+++ H NIV+L EV+ Sbjct: 64 KGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL-QKLFREVRIMKILNHPNIVKLFEVI 122 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +Y +MEY GGE+FD + G++ E A F+Q++SAV YCH + + HR Sbjct: 123 ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAE 182 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S L T CG+P Y APE+ YDG + D+WS Sbjct: 183 NLLLDADMNIKITDFG---FSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 238
>SN1L2_CHICK (Q9IA88) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 798 Score = 128 bits (321), Expect = 1e-29 Identities = 69/179 (38%), Positives = 100/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V AR + VAIK++DK ++ L E+I REV M+L+ H +I++L++VM Sbjct: 34 KGNFAVVKLARHRVTKTQVAIKIIDKTRLDPSNL-EKIYREVQIMKLLNHPHIIKLYQVM 92 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T++ +Y V E+ K GE+FD + +G L+E A K F Q++SAV+YCHS + HR Sbjct: 93 ETKDMLYIVTEFAKNGEMFDHLTSNGHLSESEARKKFWQILSAVEYCHSHHIVHRDLKTE 152 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG +S L T CG+P Y APEV Y+G DIWS Sbjct: 153 NLLLDANMNIKLADFGFGNFYKSGEP---LSTWCGSPPYAAPEVFEGKEYEGPHLDIWS 208
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 127 bits (320), Expect = 2e-29 Identities = 66/179 (36%), Positives = 99/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F KV AR + + + VA+K++DK ++ L +++ REV M+++ H NIV+L EV+ Sbjct: 68 KGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSL-QKLFREVRIMKILNHPNIVKLFEVI 126 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +Y VMEY GGE+FD + G++ E A F+Q++SAV YCH + + HR Sbjct: 127 ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAE 186 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S L T CG+P Y APE+ YDG + D+WS Sbjct: 187 NLLLDADMNIKIADFG---FSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 242
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 127 bits (320), Expect = 2e-29 Identities = 66/179 (36%), Positives = 99/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F KV AR + + + VA+K++DK ++ L +++ REV M+++ H NIV+L EV+ Sbjct: 68 KGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSL-QKLFREVRIMKILNHPNIVKLFEVI 126 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +Y VMEY GGE+FD + G++ E A F+Q++SAV YCH + + HR Sbjct: 127 ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAE 186 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S L T CG+P Y APE+ YDG + D+WS Sbjct: 187 NLLLDADMNIKIADFG---FSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 242
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 127 bits (319), Expect = 2e-29 Identities = 66/179 (36%), Positives = 99/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F KV AR + + + VA+K++DK ++ L +++ REV M+++ H NIV+L EV+ Sbjct: 68 KGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSL-QKLFREVRIMKILNHPNIVKLFEVI 126 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +Y VMEY GGE+FD + G++ E A F+Q++SAV YCH + + HR Sbjct: 127 ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAE 186 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S L T CG+P Y APE+ YDG + D+WS Sbjct: 187 NLLLDGDMNIKIADFG---FSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 242
>SN1L1_RAT (Q9R1U5) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (Salt-inducible protein kinase) (Protein kinase KID2) Length = 776 Score = 127 bits (319), Expect = 2e-29 Identities = 68/179 (37%), Positives = 100/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V AR + VAIK++DK ++ L E+I REV M+L+ H NI++L++VM Sbjct: 35 KGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNL-EKIYREVQLMKLLNHPNIIKLYQVM 93 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T++ +Y V E+ K GE+FD + +G L+E A K F Q++SAV+YCH+ + HR Sbjct: 94 ETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHNHHIVHRDLKTE 153 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG + L T CG+P Y APEV Y+G + DIWS Sbjct: 154 NLLLDGNMDIKLADFGFGNFYKPGEP---LSTWCGSPPYAAPEVFEGKEYEGPQLDIWS 209
>SN1L2_PONPY (Q5REX1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) Length = 925 Score = 127 bits (319), Expect = 2e-29 Identities = 72/184 (39%), Positives = 104/184 (56%), Gaps = 5/184 (2%) Frame = +3 Query: 9 EGTFGKVHFA-----RSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQ 173 EGT GK +FA R + VAIK++DK ++ V L E+I REV M+++ H +I++ Sbjct: 23 EGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNL-EKIYREVQIMKMLDHPHIIK 81 Query: 174 LHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR 353 L++VM T++ +Y V EY K GE+FD +A G+L E A + F Q++SAVDYCH + + HR Sbjct: 82 LYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHR 141 Query: 354 XXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKS 533 ++DF +S LL T G+P Y APEV Y+G + Sbjct: 142 DLKAENLLLDNNMNIKIADFSFGNFFKSGE---LLATWRGSPPYAAPEVFEGQQYEGPQL 198 Query: 534 DIWS 545 DIWS Sbjct: 199 DIWS 202
>SAPK1_ORYSA (Q75LR7) Serine/threonine-protein kinase SAPK1 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 1) Length = 342 Score = 127 bits (318), Expect = 3e-29 Identities = 70/181 (38%), Positives = 98/181 (54%), Gaps = 2/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G FG R + +N A+K + E+ LK+ E ++RE+ R + H NI++ EV+ Sbjct: 13 GNFGVAKLVRDVATNHLFAVKFI--ERGLKI--DEHVQREIMNHRSLKHPNIIRFKEVVL 68 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEY GGELF+++ +G+ +E A +FQQLIS V YCHS V HR Sbjct: 69 TPTHLAIVMEYAAGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQVCHRDLKLEN 128 Query: 372 XXXXXXXX--XXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFG S S Q +T GTPAY+APEV+S+ YDG +D+WS Sbjct: 129 TLLDGSVTPRLKICDFGYSKSSVLHSQP---KSTVGTPAYIAPEVLSRKEYDGKVADVWS 185 Query: 546 C 548 C Sbjct: 186 C 186
>MARK2_HUMAN (Q7KZI7) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog) Length = 788 Score = 127 bits (318), Expect = 3e-29 Identities = 66/179 (36%), Positives = 99/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F KV AR + + + VA+K++DK ++ L +++ REV M+++ H NIV+L EV+ Sbjct: 61 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL-QKLFREVRIMKVLNHPNIVKLFEVI 119 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +Y VMEY GGE+FD + G++ E A F+Q++SAV YCH + + HR Sbjct: 120 ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAE 179 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S L T CG+P Y APE+ YDG + D+WS Sbjct: 180 NLLLDADMNIKIADFG---FSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 235
>MARK2_RAT (O08679) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 722 Score = 127 bits (318), Expect = 3e-29 Identities = 66/179 (36%), Positives = 99/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F KV AR + + + VA+K++DK ++ L +++ REV M+++ H NIV+L EV+ Sbjct: 61 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL-QKLFREVRIMKVLNHPNIVKLFEVI 119 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +Y VMEY GGE+FD + G++ E A F+Q++SAV YCH + + HR Sbjct: 120 ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAE 179 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S L T CG+P Y APE+ YDG + D+WS Sbjct: 180 NLLLDADMNIKIADFG---FSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 235
>SAPK9_ORYSA (Q75V57) Serine/threonine-protein kinase SAPK9 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 9) Length = 361 Score = 127 bits (318), Expect = 3e-29 Identities = 71/182 (39%), Positives = 97/182 (53%), Gaps = 3/182 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDK-EKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 G FG R+ S VA+K +D+ EK+ E ++RE+ R + H NI++ EV+ Sbjct: 31 GNFGVARLMRNRASGDLVAVKYIDRGEKI-----DENVQREIINHRSLRHPNIIRFKEVI 85 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T + VMEY GGELF+++ +G+ +E A +FQQLIS V YCHS V HR Sbjct: 86 LTPTHLAIVMEYASGGELFERICSAGRFSEDEARFFFQQLISGVSYCHSMQVCHRDLKLE 145 Query: 369 XXXXXXXXX--XXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 + DFG S S Q +T GTPAY+APEV+ K YDG +D+W Sbjct: 146 NTLLDGSTAPRLKICDFGYSKSSVLHSQP---KSTVGTPAYIAPEVLLKKEYDGKIADVW 202 Query: 543 SC 548 SC Sbjct: 203 SC 204
>SN1L1_HUMAN (P57059) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) Length = 783 Score = 127 bits (318), Expect = 3e-29 Identities = 68/179 (37%), Positives = 100/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V AR + VAIK++DK ++ L E+I REV M+L+ H +I++L++VM Sbjct: 35 KGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNL-EKIYREVQLMKLLNHPHIIKLYQVM 93 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T++ +Y V E+ K GE+FD + +G L+E A K F Q++SAV+YCH + HR Sbjct: 94 ETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTE 153 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG +S L T CG+P Y APEV Y+G + DIWS Sbjct: 154 NLLLDGNMDIKLADFGFGNFYKSGEP---LSTWCGSPPYAAPEVFEGKEYEGPQLDIWS 209
>SAPK3_ORYSA (Q75V63) Serine/threonine-protein kinase SAPK3 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 3) (Protein kinase REK) Length = 334 Score = 126 bits (317), Expect = 4e-29 Identities = 71/183 (38%), Positives = 99/183 (54%), Gaps = 4/183 (2%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G FG R S + VA+K +++ K + E ++RE+ R + H NI++ EV Sbjct: 14 GNFGVARLVRDKRSKELVAVKYIERGKKI----DENVQREIINHRSLRHPNIIRFKEVCL 69 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEY GGELF+++ +G+ +E A +FQQLIS V YCHS + HR Sbjct: 70 TPTHLAIVMEYAAGGELFEQICTAGRFSEDEARYFFQQLISGVSYCHSLEICHRDLKLEN 129 Query: 372 XXXXXXXXXXVS--DFGL--SALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 V DFG SAL SK + +T GTPAY+APEV+S+ YDG +D+ Sbjct: 130 TLLDGSPTPRVKICDFGYSKSALLHSKPK-----STVGTPAYIAPEVLSRKEYDGKVADV 184 Query: 540 WSC 548 WSC Sbjct: 185 WSC 187
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 126 bits (317), Expect = 4e-29 Identities = 68/194 (35%), Positives = 105/194 (54%), Gaps = 15/194 (7%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVG---------------LSEQIRREVTTMR 146 G+ GKV AR+ + Q A+K++ K V G L I RE+ M+ Sbjct: 28 GSTGKVQLARNGSTGQEAAVKVISKA-VFNTGNVSGTSIVGSTTPDALPYGIEREIIIMK 86 Query: 147 LVAHKNIVQLHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDY 326 L+ H N+++L++V T +Y V+EY + GELF+ + + G L E A ++F+Q+I V Y Sbjct: 87 LLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIIIGVSY 146 Query: 327 CHSQGVYHRXXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVIS 506 CH+ G+ HR ++DFG++AL + + LL T+CG+P Y APE++S Sbjct: 147 CHALGIVHRDLKPENLLLDHKYNIKIADFGMAAL---ETEGKLLETSCGSPHYAAPEIVS 203 Query: 507 KTGYDGAKSDIWSC 548 Y G SD+WSC Sbjct: 204 GIPYQGFASDVWSC 217
>SAPKA_ORYSA (Q75H77) Serine/threonine-protein kinase SAPK10 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 10) Length = 362 Score = 125 bits (315), Expect = 6e-29 Identities = 69/181 (38%), Positives = 95/181 (52%), Gaps = 2/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G FG RS Q VA+K +++ + E ++RE+ R + H NI++ EV+ Sbjct: 32 GNFGVARLMRSRADGQLVAVKYIERGDKI----DENVQREIINHRSLRHPNIIRFKEVIL 87 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEY GGELF+++ +G+ +E A +FQQLIS V YCHS V HR Sbjct: 88 TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQVCHRDLKLEN 147 Query: 372 XXXXXXXX--XXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFG S S Q +T GTPAY+APEV+ K YDG +D+WS Sbjct: 148 TLLDGSTAPRLKICDFGYSKSSVLHSQP---KSTVGTPAYIAPEVLLKKEYDGKIADVWS 204 Query: 546 C 548 C Sbjct: 205 C 205
>ASK2_ARATH (P43292) Serine/threonine-protein kinase ASK2 (EC 2.7.11.1)| Length = 353 Score = 125 bits (314), Expect = 8e-29 Identities = 67/185 (36%), Positives = 99/185 (53%), Gaps = 6/185 (3%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G FG R ++ + VA+K +++ + + E + RE+ R + H NI++ EV+ Sbjct: 13 GNFGVARLLRHKDTKELVAMKYIERGRKI----DENVAREIINHRSLKHPNIIRFKEVIL 68 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEY GGELFD++ +G+ +E A +FQQLI VDYCHS + HR Sbjct: 69 TPTHLAIVMEYASGGELFDRICTAGRFSEAEARYFFQQLICGVDYCHSLQICHRDLKLEN 128 Query: 372 XXXXXXXX--XXVSDFGLSALSESKRQDGLLH----TTCGTPAYVAPEVISKTGYDGAKS 533 + DFG S + +LH +T GTPAY+APEV+S+ YDG + Sbjct: 129 TLLDGSPAPLLKICDFGYS-------KSSILHSRPKSTVGTPAYIAPEVLSRREYDGKHA 181 Query: 534 DIWSC 548 D+WSC Sbjct: 182 DVWSC 186
>KCC4_YEAST (P25389) Probable serine/threonine-protein kinase KCC4 (EC| 2.7.11.1) Length = 1037 Score = 125 bits (314), Expect = 8e-29 Identities = 64/187 (34%), Positives = 100/187 (53%), Gaps = 8/187 (4%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVG--------LSEQIRREVTTMRLVAHKNI 167 G+ GKV A+ + A+K++ K G L I RE+ M+L++H N+ Sbjct: 30 GSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLSHPNV 89 Query: 168 VQLHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVY 347 + L++V T N +Y ++EY + GELF+ + G L E A F+Q+I + YCH+ G+ Sbjct: 90 LSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISYCHALGIV 149 Query: 348 HRXXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGA 527 HR ++DFG++AL + LL T+CG+P Y APE++S Y+G Sbjct: 150 HRDLKPENLLLDSFYNIKIADFGMAAL---QTDADLLETSCGSPHYAAPEIVSGLPYEGF 206 Query: 528 KSDIWSC 548 SD+WSC Sbjct: 207 ASDVWSC 213
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 125 bits (314), Expect = 8e-29 Identities = 66/181 (36%), Positives = 101/181 (55%), Gaps = 1/181 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG V +++ VAIK+L++ ++ +G + R E+ ++ + H +I +L V+ Sbjct: 32 KGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTHPHITRLFRVI 91 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 +T + I+ VME V GGELF + + G L + +YFQQ+IS V YCH+ + HR Sbjct: 92 STPSDIFLVMELVSGGELFSYITRKGALPIRESRRYFQQIISGVSYCHNHMIVHRDLKPE 151 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGLS + DG LL T CG+P Y APE+IS Y G + D+WS Sbjct: 152 NLLLDANKNIKIADFGLS----NYMTDGDLLSTACGSPNYAAPELISNKLYVGPEVDLWS 207 Query: 546 C 548 C Sbjct: 208 C 208
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 125 bits (313), Expect = 1e-28 Identities = 67/179 (37%), Positives = 97/179 (54%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F KV AR + + + VAIK++DK ++ L +++ REV M+ + H NIV+L EV+ Sbjct: 67 KGNFAKVKLARHILTGREVAIKIIDKTQLNPSSL-QKLFREVRIMKGLNHPNIVKLFEVI 125 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +Y VMEY GE+FD + G++ E A F+Q++SAV YCH + + HR Sbjct: 126 ETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAE 185 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S L T CG+P Y APE+ YDG + DIWS Sbjct: 186 NLLLDAEANIKIADFG---FSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWS 241
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 125 bits (313), Expect = 1e-28 Identities = 67/179 (37%), Positives = 97/179 (54%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F KV AR + + + VAIK++DK ++ L +++ REV M+ + H NIV+L EV+ Sbjct: 67 KGNFAKVKLARHILTGREVAIKIIDKTQLNPSSL-QKLFREVRIMKGLNHPNIVKLFEVI 125 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +Y VMEY GE+FD + G++ E A F+Q++SAV YCH + + HR Sbjct: 126 ETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAE 185 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S L T CG+P Y APE+ YDG + DIWS Sbjct: 186 NLLLDAEANIKIADFG---FSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWS 241
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 124 bits (312), Expect = 1e-28 Identities = 64/179 (35%), Positives = 100/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GT+GKV A S + VAIK + K+K+ IRRE+ M + H +I+ ++EV Sbjct: 63 KGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVF 122 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++KI +MEY GEL+D +++ +L+E +F+Q++SAV YCH GV HR Sbjct: 123 ENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLE 182 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGLS L + +D L T CG+P Y +PE+++ Y G + D W+ Sbjct: 183 NILLDDNCNIKIADFGLSNLYQ---KDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWA 238
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 124 bits (310), Expect = 2e-28 Identities = 64/179 (35%), Positives = 100/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GT+GKV A S + VAIK + K+K+ IRRE+ M + H +I+ ++EV Sbjct: 64 KGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYEVF 123 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++KI +MEY GEL+D +++ +L+E +F+Q++SAV YCH GV HR Sbjct: 124 ENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLE 183 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGLS L + +D L T CG+P Y +PE+++ Y G + D W+ Sbjct: 184 NILLDDNCNIKIADFGLSNLYQ---KDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWA 239
>SAPK2_ORYSA (Q84TC6) Serine/threonine-protein kinase SAPK2 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 2) Length = 339 Score = 124 bits (310), Expect = 2e-28 Identities = 66/185 (35%), Positives = 99/185 (53%), Gaps = 6/185 (3%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G FG R + + + A+K +++ + + E ++RE+ R + H NIV+ EV+ Sbjct: 13 GNFGVAKLVRDVRTKELFAVKFIERGQKI----DENVQREIMNHRSLRHPNIVRFKEVVL 68 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEY GGELF+++ +G+ +E A +FQQLIS V YCHS + HR Sbjct: 69 TPTHLAIVMEYAAGGELFERICSAGRFSEDEARFFFQQLISGVSYCHSMQICHRDLKLEN 128 Query: 372 XXXXXXXX--XXVSDFGLSALSESKRQDGLLH----TTCGTPAYVAPEVISKTGYDGAKS 533 + DFG S + LLH +T GTPAY+APEV+++ YDG + Sbjct: 129 TLLDGSIAPRLKICDFGYS-------KSSLLHSQPKSTVGTPAYIAPEVLARKEYDGKVA 181 Query: 534 DIWSC 548 D+WSC Sbjct: 182 DVWSC 186
>RKIN1_SECCE (Q02723) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 502 Score = 122 bits (307), Expect = 5e-28 Identities = 69/183 (37%), Positives = 103/183 (56%), Gaps = 4/183 (2%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRL---VAHKNIVQLHE 182 GTF KV A + VAIK+L++ ++ + E+ +RE+ +RL + H +I++++E Sbjct: 23 GTFAKVIIAEHKHTRHKVAIKVLNRRQMRAPEMEEKAKREIKILRLFIDLIHPHIIRVYE 82 Query: 183 VMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXX 362 V+ T I+ VMEY + G+L D + + +L E A + FQQ+ISAV+YCH V HR Sbjct: 83 VIVTPKDIFVVMEYCQNGDLLDYILEKRRLQEDEARRTFQQIISAVEYCHRNKVVHRDLK 142 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGLS + DG L T+CG+ Y APEVIS Y G + D+ Sbjct: 143 PENLLLDSKYNVKLADFGLS----NVMHDGHFLKTSCGSLNYAAPEVISGKLYAGPEIDV 198 Query: 540 WSC 548 WSC Sbjct: 199 WSC 201
>SAPK7_ORYSA (Q7XQP4) Serine/threonine-protein kinase SAPK7 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 7) Length = 359 Score = 122 bits (307), Expect = 5e-28 Identities = 67/185 (36%), Positives = 97/185 (52%), Gaps = 6/185 (3%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G FG R+ E+ + VA+K + + + + E + RE+ R + H NI++ EV+ Sbjct: 13 GNFGVARLMRNKETKELVAMKYIPRG----LKIDENVAREIINHRSLRHPNIIRFKEVVV 68 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEY GGELFD++ +G+ +E A +FQQLI V YCH + HR Sbjct: 69 TPTHLAIVMEYAAGGELFDRICNAGRFSEDEARYFFQQLICGVSYCHFMQICHRDLKLEN 128 Query: 372 XXXXXXXX--XXVSDFGLSALSESKRQDGLLH----TTCGTPAYVAPEVISKTGYDGAKS 533 + DFG S + LLH +T GTPAY+APEV+S+ YDG + Sbjct: 129 TLLDGSPAPRLKICDFGYS-------KSSLLHSKPKSTVGTPAYIAPEVLSRREYDGKTA 181 Query: 534 DIWSC 548 D+WSC Sbjct: 182 DVWSC 186
>AAIP_WHEAT (Q02066) Abscisic acid-inducible protein kinase (EC 2.7.11.1)| (Fragment) Length = 332 Score = 122 bits (307), Expect = 5e-28 Identities = 65/181 (35%), Positives = 94/181 (51%), Gaps = 2/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G FG R + + + A+K +++ + E ++RE+ R + H NI++ EV+ Sbjct: 3 GNFGVAKLVRDVRTKEHFAVKFIERGHKI----DEHVQREIMNHRSLKHPNIIRFKEVVL 58 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEY GGELF ++ +G+ +E +FQQLIS V YCHS V HR Sbjct: 59 TPTHLAIVMEYASGGELFQRICNAGRFSEDEGRFFFQQLISGVSYCHSMQVCHRDLKLEN 118 Query: 372 XXXXXXXX--XXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFG S S Q +T GTPAY+APEV+S+ YDG +D+WS Sbjct: 119 TLLDGSVAPRLKICDFGYSKSSVLHSQP---KSTVGTPAYIAPEVLSRREYDGKVADVWS 175 Query: 546 C 548 C Sbjct: 176 C 176
>SN1L1_MOUSE (Q60670) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1-like kinase) Length = 779 Score = 122 bits (306), Expect = 7e-28 Identities = 65/179 (36%), Positives = 99/179 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V AR + VAIK++DK ++ L E+I REV M+L+ H NI++L++VM Sbjct: 35 KGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNL-EKIYREVQLMKLLNHPNIIKLYQVM 93 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T++ +Y V E+ K GE+FD + +G L+E A + F Q++SAV+YCH+ + HR Sbjct: 94 ETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQILSAVEYCHNHHIVHRDLKTE 153 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG + L T G+P Y APEV Y+G + D+WS Sbjct: 154 NLLLDSNMDIKLADFGFGNFYKPGEP---LSTCVGSPPYAAPEVFEGKEYEGPQLDVWS 209
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 122 bits (306), Expect = 7e-28 Identities = 69/216 (31%), Positives = 107/216 (49%), Gaps = 36/216 (16%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVL-------------------------KVGLS 113 +G+ G+V A+++E+ Q AIK++ K+K + Sbjct: 89 KGSSGRVRLAKNMETGQLAAIKIVPKKKAFVHCSNNGTVPNSYSSSMVTSNVSSPSIASR 148 Query: 114 EQ----------IRREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVKGGELFDKVAKS 263 E I RE+ M+L++H N++ L EV ++++Y V+EYV GGELFD + Sbjct: 149 EHSNHSQTNPYGIEREIVIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFDYLVSK 208 Query: 264 GKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXX-XXXXXXXXXXXXXVSDFGLSALSESK 440 GKL E A YF+Q++ V YCHS + HR ++DFG++AL Sbjct: 209 GKLPEREAIHYFKQIVEGVSYCHSFNICHRDLKPENLLLDKKNRRIKIADFGMAALELPN 268 Query: 441 RQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 + LL T+CG+P Y +PE++ Y G SD+WSC Sbjct: 269 K---LLKTSCGSPHYASPEIVMGRPYHGGPSDVWSC 301
>SAPK8_ORYSA (Q7Y0B9) Serine/threonine-protein kinase SAPK8 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 8) Length = 371 Score = 122 bits (305), Expect = 9e-28 Identities = 68/182 (37%), Positives = 97/182 (53%), Gaps = 3/182 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDK-EKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 G FG R + + VA+K +++ EK+ + ++RE+ R + H NI++ EV+ Sbjct: 42 GNFGVARLMRDRRTMELVAVKYIERGEKI-----DDNVQREIINHRSLKHPNIIRFKEVI 96 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T + VMEY GGELF+++ K+ + +E A +FQQLIS V YCHS V HR Sbjct: 97 LTPTHLAIVMEYASGGELFERICKNVRFSEDEARYFFQQLISGVSYCHSMQVCHRDLKLE 156 Query: 369 XXXXXXXXX--XXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 + DFG S S Q +T GTPAY+APEV+ K YDG +D+W Sbjct: 157 NTLLDGSPAPRLKICDFGYSKSSVLHSQP---KSTVGTPAYIAPEVLLKKEYDGKTADVW 213 Query: 543 SC 548 SC Sbjct: 214 SC 215
>CHK1_XENLA (Q6DE87) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (xChk1| protein) Length = 474 Score = 121 bits (304), Expect = 1e-27 Identities = 62/180 (34%), Positives = 99/180 (55%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG +G+V A + ++ ++VA+K++D + E I++E+ R+++H NIV+ + Sbjct: 17 EGAYGEVQLAVNRKTEEAVAVKIVDMTRA--ADCPENIKKEICINRMLSHTNIVRFYGHR 74 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 N Y +EY +GGELFD++ + E A K+FQQLI+ V+Y HS G+ HR Sbjct: 75 REGNIQYLFLEYCRGGELFDRIEPDVGMPEQDAQKFFQQLIAGVEYLHSIGITHRDIKPE 134 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 +SDFGL+ + ++ LL+ CGT YVAPE+I + D+WSC Sbjct: 135 NLLLDERDQLKISDFGLATVFRHNGKERLLNKMCGTLPYVAPELIKSRAFHADPVDVWSC 194
>SAPK5_ORYSA (Q7XKA8) Serine/threonine-protein kinase SAPK5 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 5) Length = 370 Score = 121 bits (303), Expect = 1e-27 Identities = 65/185 (35%), Positives = 98/185 (52%), Gaps = 6/185 (3%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G FG R+ E+ + VA+K +++ + E + RE+ R + H NI++ EV+ Sbjct: 13 GNFGVAKLMRNKETRELVAMKFIERGN----RIDENVFREIVNHRSLRHPNIIRFKEVVV 68 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEY GGELF+++ ++G+ E A +FQQL+ V YCH+ + HR Sbjct: 69 TGRHLAIVMEYAAGGELFERICEAGRFHEDEARYFFQQLVCGVSYCHAMQICHRDLKLEN 128 Query: 372 XXXXXXXX--XXVSDFGLSALSESKRQDGLLH----TTCGTPAYVAPEVISKTGYDGAKS 533 + DFG S + LLH +T GTPAY+APEV+S+ YDG + Sbjct: 129 TLLDGSPAPRLKICDFGYS-------KSSLLHSRPKSTVGTPAYIAPEVLSRREYDGKLA 181 Query: 534 DIWSC 548 D+WSC Sbjct: 182 DVWSC 186
>SAPK6_ORYSA (Q6ZI44) Serine/threonine-protein kinase SAPK6 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 6) Length = 365 Score = 121 bits (303), Expect = 1e-27 Identities = 66/185 (35%), Positives = 97/185 (52%), Gaps = 6/185 (3%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G FG R+ E+ + VA+K + + + + E + RE+ R + H NI++ EV+ Sbjct: 13 GNFGVARLMRNRETKELVAMKYIPRG----LKIDENVAREIINHRSLRHPNIIRFKEVVL 68 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VMEY GGELFD++ +G+ +E + +FQQLI V YCH + HR Sbjct: 69 TPTHLAIVMEYAAGGELFDRICSAGRFSEDESRYFFQQLICGVSYCHFMQICHRDLKLEN 128 Query: 372 XXXXXXXX--XXVSDFGLSALSESKRQDGLLH----TTCGTPAYVAPEVISKTGYDGAKS 533 + DFG S + LLH +T GTPAY+APEV+S+ YDG + Sbjct: 129 TLLDGSPAPRLKICDFGYS-------KSSLLHSKPKSTVGTPAYIAPEVLSRREYDGKMA 181 Query: 534 DIWSC 548 D+WSC Sbjct: 182 DVWSC 186
>ASK1_ARATH (P43291) Serine/threonine-protein kinase ASK1 (EC 2.7.11.1)| Length = 363 Score = 119 bits (299), Expect = 4e-27 Identities = 65/185 (35%), Positives = 96/185 (51%), Gaps = 6/185 (3%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G FG + S + VA+K +++ + E + RE+ R + H NI++ EV+ Sbjct: 13 GNFGVARLMKVKNSKELVAMKYIERGPKI----DENVAREIINHRSLRHPNIIRFKEVVL 68 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + MEY GGELF+++ +G+ +E A +FQQLIS V YCH+ + HR Sbjct: 69 TPTHLAIAMEYAAGGELFERICSAGRFSEDEARYFFQQLISGVSYCHAMQICHRDLKLEN 128 Query: 372 XXXXXXXX--XXVSDFGLSALSESKRQDGLLH----TTCGTPAYVAPEVISKTGYDGAKS 533 + DFG S + LLH +T GTPAY+APEV+S+ YDG + Sbjct: 129 TLLDGSPAPRLKICDFGYS-------KSSLLHSRPKSTVGTPAYIAPEVLSRREYDGKMA 181 Query: 534 DIWSC 548 D+WSC Sbjct: 182 DVWSC 186
>MARK2_MOUSE (Q05512) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 776 Score = 119 bits (298), Expect = 6e-27 Identities = 63/179 (35%), Positives = 96/179 (53%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F KV AR + + + VA+K++DK ++ L +++ REV M+++ H NIV+L EV+ Sbjct: 61 KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL-QKLFREVRIMKVLNHPNIVKLFEVI 119 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +Y VMEY GGE+FD + G++ E A F+Q++ V YCH + + HR Sbjct: 120 ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVLHVQYCHQKFIVHRDLKAE 179 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S L T CG+P Y APE+ DG + D+WS Sbjct: 180 NLLLDADMNIKIADFG---FSNEFTFGNKLDTFCGSPPYAAPELFQGKKIDGPEVDVWS 235
>HUNK_PANTR (Q68UT7) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) Length = 714 Score = 119 bits (297), Expect = 7e-27 Identities = 65/180 (36%), Positives = 98/180 (54%), Gaps = 1/180 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLK-VGLSEQIRREVTTMRLVAHKNIVQLHEV 185 EG+F KV + + + VAIK++DK++ K +++ +RRE +++ H NI QL ++ Sbjct: 70 EGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDI 129 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 + T N Y VME GG L K+ + +L E A +Y +QLISAV++ H GV HR Sbjct: 130 LETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKI 189 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFGLS + T CG+PAY APE++++ Y G K D+WS Sbjct: 190 ENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDVWS 248
>HUNK_MOUSE (O88866) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Length = 714 Score = 119 bits (297), Expect = 7e-27 Identities = 65/180 (36%), Positives = 98/180 (54%), Gaps = 1/180 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLK-VGLSEQIRREVTTMRLVAHKNIVQLHEV 185 EG+F KV + + + VAIK++DK++ K +++ +RRE +++ H NI QL ++ Sbjct: 70 EGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDI 129 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 + T N Y VME GG L K+ + +L E A +Y +QLISAV++ H GV HR Sbjct: 130 LETENSYYLVMELCPGGNLMHKIYEKKRLDEAEARRYIRQLISAVEHLHRAGVVHRDLKI 189 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFGLS + T CG+PAY APE++++ Y G K D+WS Sbjct: 190 ENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDVWS 248
>HUNK_HUMAN (P57058) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19) Length = 714 Score = 119 bits (297), Expect = 7e-27 Identities = 65/180 (36%), Positives = 98/180 (54%), Gaps = 1/180 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLK-VGLSEQIRREVTTMRLVAHKNIVQLHEV 185 EG+F KV + + + VAIK++DK++ K +++ +RRE +++ H NI QL ++ Sbjct: 70 EGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDI 129 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 + T N Y VME GG L K+ + +L E A +Y +QLISAV++ H GV HR Sbjct: 130 LETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKI 189 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFGLS + T CG+PAY APE++++ Y G K D+WS Sbjct: 190 ENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDVWS 248
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 118 bits (295), Expect = 1e-26 Identities = 67/178 (37%), Positives = 101/178 (56%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F KV A + + + VAIK++DK L L +++ E+ ++ + H++I QL+ V+ Sbjct: 20 GGFAKVKLACHVLTGEMVAIKIMDKN-ALGSDLP-RVKTEIDALKSLRHQHICQLYHVLE 77 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T+NKI+ V+EY GGELFD + +L+E F+Q++SAV Y HSQG HR Sbjct: 78 TKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPEN 137 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFGL A + + D L T CG+ AY APE+I Y G+++D+WS Sbjct: 138 LLFDENHKLKLIDFGLCAKPKGNK-DYHLQTCCGSLAYAAPELIQGKSYLGSEADVWS 194
>MARK3_HUMAN (P27448) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10) Length = 776 Score = 118 bits (295), Expect = 1e-26 Identities = 67/202 (33%), Positives = 100/202 (49%), Gaps = 23/202 (11%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F KV AR + + + VAIK++DK ++ L +++ REV M+++ H NIV+L EV+ Sbjct: 64 KGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL-QKLFREVRIMKILNHPNIVKLFEVI 122 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQ--------------------- 305 T +Y +MEY GGE+FD + G++ E A F+Q Sbjct: 123 ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMF 182 Query: 306 --LISAVDYCHSQGVYHRXXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTP 479 ++SAV YCH + + HR ++DFG S G L T CG+P Sbjct: 183 TFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFG---FSNEFTVGGKLDTFCGSP 239 Query: 480 AYVAPEVISKTGYDGAKSDIWS 545 Y APE+ YDG + D+WS Sbjct: 240 PYAAPELFQGKKYDGPEVDVWS 261
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 117 bits (294), Expect = 2e-26 Identities = 68/178 (38%), Positives = 100/178 (56%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F KV A + + + VAIK++DK L L +I+ E+ ++ + H++I QL+ V+ Sbjct: 20 GGFAKVKLACHILTGEMVAIKIMDKN-TLGSDLP-RIKTEIEALKNLRHQHICQLYHVLE 77 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T NKI+ V+EY GGELFD + +L+E F+Q++SAV Y HSQG HR Sbjct: 78 TANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPEN 137 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFGL A + + D L T CG+ AY APE+I Y G+++D+WS Sbjct: 138 LLFDEYHKLKLIDFGLCAKPKGNK-DYHLQTCCGSLAYAAPELIQGKSYLGSEADVWS 194
>SAPK4_ORYSA (Q5N942) Serine/threonine-protein kinase SAPK4 (EC 2.7.11.1)| (Osmotic stress/abscisic acid-activated protein kinase 4) Length = 360 Score = 117 bits (293), Expect = 2e-26 Identities = 64/185 (34%), Positives = 95/185 (51%), Gaps = 6/185 (3%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G FG R+ E+ + VA+K +++ + E + RE+ R + H NI++ EV+ Sbjct: 13 GNFGVARLMRNRETRELVAVKCIERGH----RIDENVYREIINHRSLRHPNIIRFKEVIL 68 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T + VME+ GGELFD++ G+ +E A +FQQLI V YCH + HR Sbjct: 69 TPTHLMIVMEFAAGGELFDRICDRGRFSEDEARYFFQQLICGVSYCHHMQICHRDLKLEN 128 Query: 372 XXXXXXXX--XXVSDFGLSALSESKRQDGLLH----TTCGTPAYVAPEVISKTGYDGAKS 533 + DFG S + +LH + GTPAY+APEV+S+ YDG + Sbjct: 129 VLLDGSPAPRLKICDFGYS-------KSSVLHSRPKSAVGTPAYIAPEVLSRREYDGKLA 181 Query: 534 DIWSC 548 D+WSC Sbjct: 182 DVWSC 186
>TSSK3_MOUSE (Q9D2E1) Testis-specific serine/threonine-protein kinase 3 (EC| 2.7.11.1) (TSSK-3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C) Length = 268 Score = 117 bits (292), Expect = 3e-26 Identities = 66/180 (36%), Positives = 101/180 (56%), Gaps = 1/180 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EGT+ KV A S + + VAIK++DK + + + RE+ +R + HKNI+Q++E++ Sbjct: 18 EGTYSKVKEAFSKKHQRKVAIKIIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEML 77 Query: 189 ATRN-KIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 + + KIY VME +GG++FD V G L E A F+Q++ A+ YCH GV HR Sbjct: 78 ESADGKIYLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHR-DLK 136 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG + + R++ L T CG+ AY APEV+ +D K D+WS Sbjct: 137 CENALLQGFNLKLTDFGFAKVLPKSRRE-LSQTFCGSTAYAAPEVLQGIPHDSKKGDVWS 195
>MYLK_DICDI (P25323) Myosin light chain kinase (EC 2.7.11.18) (MLCK)| Length = 295 Score = 115 bits (287), Expect = 1e-25 Identities = 65/181 (35%), Positives = 100/181 (55%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F V+ + ++ Q AIK+++K ++ K + ++ EV ++ V H NI+ L E+ Sbjct: 17 GAFSIVYLGENKQTKQRYAIKVINKSELGK-DYEKNLKMEVDILKKVNHPNIIALKELFD 75 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 T K+Y VME V GGELFDK+ + G +E A ++++SAV Y H + HR Sbjct: 76 TPEKLYLVMELVTGGELFDKIVEKGSYSEADAANLVKKIVSAVGYLHGLNIVHRDLKPEN 135 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGLS + Q ++ T CGTP+YVAPEV++ TGYD + D+W Sbjct: 136 LLLKSKENHLEVAIADFGLSKII---GQTLVMQTACGTPSYVAPEVLNATGYD-KEVDMW 191 Query: 543 S 545 S Sbjct: 192 S 192
>CDR2_SCHPO (P87050) Mitosis inducer protein kinase cdr2 (EC 2.7.11.1)| Length = 775 Score = 114 bits (285), Expect = 2e-25 Identities = 54/171 (31%), Positives = 93/171 (54%) Frame = +3 Query: 36 ARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMATRNKIYFV 215 A+ E+ Q +K + L +I E+ +RL+ H N++QL +V++ + +++ V Sbjct: 27 AKHRETGQLAVVKPIVGWSELTSSQQARIEGELVLLRLIEHPNVLQLIDVISAQEQLFVV 86 Query: 216 MEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXXXXXXXXXX 395 +EY+ GGELFD + + G TE K+ Q++ ++YCH + HR Sbjct: 87 VEYMPGGELFDCMLRKGSFTEQDTAKFLWQILCGLEYCHKLHICHRDLKPENLYLDAHGS 146 Query: 396 XXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 + +FG++++ + + LL T+CG+P Y +PE+I YDG SDIWSC Sbjct: 147 IKIGEFGMASIQQPGK---LLQTSCGSPHYASPEIIMGRSYDGCASDIWSC 194
>KIN4_YEAST (Q01919) Serine/threonine-protein kinase KIN4 (EC 2.7.11.1)| Length = 800 Score = 114 bits (284), Expect = 2e-25 Identities = 65/187 (34%), Positives = 102/187 (54%), Gaps = 7/187 (3%) Frame = +3 Query: 9 EGTFGKVHF-----ARSLESNQSVAIKMLDKEKVLKVGLSE-QIRREVTTMRLVAHKNIV 170 EG FGKV + S E + VAIK++ ++ + K E +I RE+ ++ + H NI+ Sbjct: 54 EGEFGKVKLGWTKASSSNEVPKQVAIKLIRRDTIKKDADKEIKIYREINALKHLTHPNII 113 Query: 171 QLHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYH 350 L EV+ I V+E+V GGE + + + +L E +A + F QLIS V+Y H +G+ H Sbjct: 114 YLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSACRLFAQLISGVNYMHYKGLVH 173 Query: 351 RXXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPE-VISKTGYDGA 527 R ++DFG ++E + L+ T+CG+P Y APE V+S Y+ Sbjct: 174 RDLKLENLLLDKHENLVITDFGF--VNEFFEDNELMKTSCGSPCYAAPELVVSTKAYEAR 231 Query: 528 KSDIWSC 548 K+D+WSC Sbjct: 232 KADVWSC 238
>CHK1_CHICK (Q8AYC9) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 113 bits (282), Expect = 4e-25 Identities = 56/180 (31%), Positives = 98/180 (54%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG +G+V A + + ++VA+K++D ++ E I++E+ +++ H+N+V+ + Sbjct: 17 EGAYGEVQLAVNRRTEEAVAVKIVDMKRA--ADCPENIKKEICINKMLNHENVVKFYGHR 74 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 Y +EY GGELFD++ + E A ++FQQLI+ V Y HS G+ HR Sbjct: 75 REGATQYLFLEYCSGGELFDRIEPDIGMPEPEAQRFFQQLIAGVVYLHSMGITHRDLKPE 134 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 +SDFGL+ + + ++ LL+ CGT YVAPE++ + + D+W+C Sbjct: 135 NLLLDERDNLKISDFGLATVFKHNGRERLLNKMCGTLPYVAPELLRRPEFRAEPVDVWAC 194
>YP141_YEAST (Q03002) Putative serine/threonine-protein kinase YPL141C (EC| 2.7.11.1) Length = 865 Score = 112 bits (280), Expect = 7e-25 Identities = 70/192 (36%), Positives = 104/192 (54%), Gaps = 12/192 (6%) Frame = +3 Query: 9 EGTFGKV------HFARSLESN----QSVAIKMLDKEKVLKVGLSE-QIRREVTTMRLVA 155 EG FGKV +F+ S S + VAIK++ ++ + E +I RE+ ++ ++ Sbjct: 49 EGEFGKVKLGWPKNFSNSSNSTFDFPKQVAIKLIKRDSISNDYRKEVKIYREINALKHLS 108 Query: 156 HKNIVQLHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHS 335 H NIV+L EV+ I V+EY GGE + + K +L E A + F QLIS V Y HS Sbjct: 109 HPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQKKRRLKEMNACRLFSQLISGVHYIHS 168 Query: 336 QGVYHRXXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPE-VISKT 512 +G+ HR ++DFG ++E ++ L+ T+CG+P Y APE VIS Sbjct: 169 KGLVHRDLKLENLLLDKNENLVITDFGF--VNEFCSRNELMKTSCGSPCYAAPELVISAE 226 Query: 513 GYDGAKSDIWSC 548 Y+ K+DIWSC Sbjct: 227 PYEARKADIWSC 238
>DCAK1_MOUSE (Q9JLM8) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 756 Score = 112 bits (279), Expect = 9e-25 Identities = 69/183 (37%), Positives = 93/183 (50%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V + + A+K++ K K G I+ EV+ +R V H NIV L E M Sbjct: 414 DGNFAVVKECIERSTAREYALKIIKKSKCR--GKEHMIQNEVSILRRVKHPNIVLLIEEM 471 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----X 356 ++Y VME VKGG+LFD + + K TE A L SA+ Y HS + HR Sbjct: 472 DVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPE 531 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 + DFGL+ + DG L+T CGTP YVAPE+I++TGY G K D Sbjct: 532 NLLVYEHQDGSKSLKLGDFGLATI-----VDGPLYTVCGTPTYVAPEIIAETGY-GLKVD 585 Query: 537 IWS 545 IW+ Sbjct: 586 IWA 588
>DCAK1_RAT (O08875) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) Length = 433 Score = 112 bits (279), Expect = 9e-25 Identities = 69/183 (37%), Positives = 93/183 (50%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V + + A+K++ K K G I+ EV+ +R V H NIV L E M Sbjct: 91 DGNFAVVKECIERSTAREYALKIIKKSKCR--GKEHMIQNEVSILRRVKHPNIVLLIEEM 148 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----X 356 ++Y VME VKGG+LFD + + K TE A L SA+ Y HS + HR Sbjct: 149 DVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPE 208 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 + DFGL+ + DG L+T CGTP YVAPE+I++TGY G K D Sbjct: 209 NLLVYEHQDGSKSLKLGDFGLATI-----VDGPLYTVCGTPTYVAPEIIAETGY-GLKVD 262 Query: 537 IWS 545 IW+ Sbjct: 263 IWA 265
>DCAK1_HUMAN (O15075) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 740 Score = 112 bits (279), Expect = 9e-25 Identities = 69/183 (37%), Positives = 93/183 (50%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V + + A+K++ K K G I+ EV+ +R V H NIV L E M Sbjct: 398 DGNFAVVKECVERSTAREYALKIIKKSKCR--GKEHMIQNEVSILRRVKHPNIVLLIEEM 455 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----X 356 ++Y VME VKGG+LFD + + K TE A L SA+ Y HS + HR Sbjct: 456 DVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPE 515 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 + DFGL+ + DG L+T CGTP YVAPE+I++TGY G K D Sbjct: 516 NLLVYEHQDGSKSLKLGDFGLATI-----VDGPLYTVCGTPTYVAPEIIAETGY-GLKVD 569 Query: 537 IWS 545 IW+ Sbjct: 570 IWA 572
>TSSK3_HUMAN (Q96PN8) Testis-specific serine/threonine-protein kinase 3 (EC| 2.7.11.1) (TSSK-3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C) Length = 268 Score = 112 bits (279), Expect = 9e-25 Identities = 67/181 (37%), Positives = 101/181 (55%), Gaps = 2/181 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EGT+ KV A S + + VAIK++DK + + + RE+ +R + HKNI+Q++E++ Sbjct: 18 EGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEML 77 Query: 189 ATRN-KIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 + + KI VME +GG++FD V G L E A F+Q++ A+ YCH GV HR Sbjct: 78 ESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHR-DLK 136 Query: 366 XXXXXXXXXXXXVSDFGLS-ALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFG + L +S R+ L T CG+ AY APEV+ +D K D+W Sbjct: 137 CENALLQGFNLKLTDFGFAKVLPKSHRE--LSQTFCGSTAYAAPEVLQGIPHDSKKGDVW 194 Query: 543 S 545 S Sbjct: 195 S 195
>CHK1_HUMAN (O14757) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 112 bits (279), Expect = 9e-25 Identities = 56/180 (31%), Positives = 97/180 (53%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG +G+V A + + ++VA+K++D ++ V E I++E+ +++ H+N+V+ + Sbjct: 17 EGAYGEVQLAVNRVTEEAVAVKIVDMKRA--VDCPENIKKEICINKMLNHENVVKFYGHR 74 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 N Y +EY GGELFD++ + E A ++F QL++ V Y H G+ HR Sbjct: 75 REGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPE 134 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 +SDFGL+ + ++ LL+ CGT YVAPE++ + + D+WSC Sbjct: 135 NLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSC 194
>CHK1_RAT (Q91ZN7) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 111 bits (278), Expect = 1e-24 Identities = 55/180 (30%), Positives = 97/180 (53%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG +G+V A + + ++VA+K++D ++ + E I++E+ +++ H+N+V+ + Sbjct: 17 EGAYGEVQLAVNRITEEAVAVKIVDMKRA--IDCPENIKKEICINKMLNHENVVKFYGHR 74 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 N Y +EY GGELFD++ + E A ++F QL++ V Y H G+ HR Sbjct: 75 REGNIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPE 134 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 +SDFGL+ + ++ LL+ CGT YVAPE++ + + D+WSC Sbjct: 135 NLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSC 194
>SNRK_RAT (Q63553) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 746 Score = 111 bits (277), Expect = 2e-24 Identities = 69/181 (38%), Positives = 100/181 (55%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F V AR + + + VA+K++DK K L + + +EV M+LV H NIV+L+EV+ Sbjct: 25 GHFAVVKLARHVFTGEKVAVKVIDKTK-LDTLATGHLFQEVRCMKLVQHPNIVRLYEVID 83 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGK-LTEGAAHKYFQQLISAVDYCHSQGVYHRXXX-X 365 T+ K+Y ++E GG++FD + K + L E A KYF Q++ A+ YCH V HR Sbjct: 84 TQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPE 143 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFG S +K Q G L T+CG+ AY APE++ YD DIW Sbjct: 144 NVVFFEKQGLVKLTDFGFS----NKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIW 199 Query: 543 S 545 S Sbjct: 200 S 200
>SNRK_HUMAN (Q9NRH2) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 765 Score = 111 bits (277), Expect = 2e-24 Identities = 69/181 (38%), Positives = 100/181 (55%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F V AR + + + VA+K++DK K L + + +EV M+LV H NIV+L+EV+ Sbjct: 25 GHFAVVKLARHVFTGEKVAVKVIDKTK-LDTLATGHLFQEVRCMKLVQHPNIVRLYEVID 83 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGK-LTEGAAHKYFQQLISAVDYCHSQGVYHRXXX-X 365 T+ K+Y ++E GG++FD + K + L E A KYF Q++ A+ YCH V HR Sbjct: 84 TQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPE 143 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFG S +K Q G L T+CG+ AY APE++ YD DIW Sbjct: 144 NVVFFEKQGLVKLTDFGFS----NKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIW 199 Query: 543 S 545 S Sbjct: 200 S 200
>SNRK_MOUSE (Q8VDU5) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 748 Score = 111 bits (277), Expect = 2e-24 Identities = 69/181 (38%), Positives = 100/181 (55%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F V AR + + + VA+K++DK K L + + +EV M+LV H NIV+L+EV+ Sbjct: 25 GHFAVVKLARHVFTGEKVAVKVIDKTK-LDTLATGHLFQEVRCMKLVQHPNIVRLYEVID 83 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGK-LTEGAAHKYFQQLISAVDYCHSQGVYHRXXX-X 365 T+ K+Y ++E GG++FD + K + L E A KYF Q++ A+ YCH V HR Sbjct: 84 TQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPE 143 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDG-LLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFG S +K Q G L T+CG+ AY APE++ YD DIW Sbjct: 144 NVVFFEKQGLVKLTDFGFS----NKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIW 199 Query: 543 S 545 S Sbjct: 200 S 200
>CHK1_DROME (O61661) Serine/threonine-protein kinase grp (EC 2.7.11.1) (Protein| grapes) (Chk1 homolog) Length = 512 Score = 110 bits (276), Expect = 2e-24 Identities = 57/180 (31%), Positives = 98/180 (54%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG +G+V + ++ ++VA+KM+D +K + +R+EV +++ K+I++ Sbjct: 30 EGAYGEVKLLINRQTGEAVAMKMVDLKK--HPDAANSVRKEVCIQKMLQDKHILRFFGKR 87 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 + + Y +EY GGELFD++ + + A +YF QL+S ++Y H +G+ HR Sbjct: 88 SQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPE 147 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 +SDFG++ + K ++ LL CGT YVAPEV+ K Y +D+WSC Sbjct: 148 NLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQK-AYHAQPADLWSC 206
>CHK1_MOUSE (O35280) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 110 bits (276), Expect = 2e-24 Identities = 54/180 (30%), Positives = 98/180 (54%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG +G+V A + + ++VA+K++D ++ + E I++E+ ++++H+N+V+ + Sbjct: 17 EGAYGEVQLAVNRITEEAVAVKIVDMKRA--IDCPENIKKEICINKMLSHENVVKFYGHR 74 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 + Y +EY GGELFD++ + E A ++F QL++ V Y H G+ HR Sbjct: 75 REGHIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPE 134 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWSC 548 +SDFGL+ + ++ LL+ CGT YVAPE++ + + D+WSC Sbjct: 135 NLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSC 194
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 109 bits (273), Expect = 4e-24 Identities = 67/183 (36%), Positives = 92/183 (50%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V + + A+K++DK K G I EV+ +R V H NI+ L E M Sbjct: 402 DGNFAVVKECIDRSTGKEFALKIIDKAKCC--GKEHLIENEVSILRRVKHPNIIMLVEEM 459 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +++ VME VKGG+LFD + S K TE L +A+ Y H + HR Sbjct: 460 ETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPE 519 Query: 369 XXXX----XXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 + DFGL+ + E G L+T CGTP YVAPE+I++TGY G K D Sbjct: 520 NLLVCEYPDGTKSLKLGDFGLATVVE-----GPLYTVCGTPTYVAPEIIAETGY-GLKVD 573 Query: 537 IWS 545 IW+ Sbjct: 574 IWA 576
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 109 bits (272), Expect = 6e-24 Identities = 67/183 (36%), Positives = 92/183 (50%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V + + A+K++DK K G I EV+ +R V H NI+ L E M Sbjct: 401 DGNFAVVKECVDRYTGKEFALKIIDKAKCC--GKEHLIENEVSILRRVKHPNIIMLVEEM 458 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T ++ VME VKGG+LFD + S K TE L +A+ Y HS + HR Sbjct: 459 ETATDLFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPE 518 Query: 369 XXXX----XXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 + DFGL+ + E G L+T CGTP YVAPE+I++TGY G K D Sbjct: 519 NLLVCEYPDGTKSLKLGDFGLATVVE-----GPLYTVCGTPTYVAPEIIAETGY-GLKVD 572 Query: 537 IWS 545 +W+ Sbjct: 573 VWA 575
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 109 bits (272), Expect = 6e-24 Identities = 62/178 (34%), Positives = 93/178 (52%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG V+ AR ES+ VA+K+L K ++ K GL Q+RRE+ + H NI++L+ Sbjct: 51 KGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYF 110 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++Y ++EY GEL+ ++ KS KL E ++L A+ YCH + V HR Sbjct: 111 HDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPE 170 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFG S + S R+ T CGT Y+ PE+I YD K D+W Sbjct: 171 NLLLGFRGEVKIADFGWSVHTPSLRR----KTMCGTLDYLPPEMIEGRTYD-EKVDLW 223
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 108 bits (271), Expect = 8e-24 Identities = 61/179 (34%), Positives = 96/179 (53%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG V+ AR ES +A+K+L K ++ K G+ Q+RREV + H NI++L+ Sbjct: 148 KGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYF 207 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 +++Y +++Y GGELF ++ K + + + Y +QL A+ YCHS+ V HR Sbjct: 208 HDASRVYLILDYAPGGELFRELQKCTRFDDQRSALYIKQLAEALLYCHSKKVIHRDIKPE 267 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S + S R+ T CGT Y+ PE+I +D K D+WS Sbjct: 268 NLLLGSNGELKIADFGWSVHAPSSRRT----TLCGTLDYLPPEMIEGRMHD-EKVDLWS 321
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 108 bits (269), Expect = 1e-23 Identities = 61/177 (34%), Positives = 95/177 (53%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G FG+V+ AR E++ VA+K+L K ++ K GL Q+RREV + H+NI++L+ Sbjct: 25 GKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRNILRLYNYFY 84 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 +IY ++EY GGEL+ ++ + KL + Q+L A+ YCH + V HR Sbjct: 85 DDTRIYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDALTYCHEKKVIHRDIKPEN 144 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 +SDFG S + S R+ T CGT Y+ PE+I++ Y+ D+W Sbjct: 145 LLLGLNGEVKISDFGWSVHTPSLRR----KTMCGTLDYLPPEMIAQKPYN-EMVDLW 196
>KPSH1_PINFU (Q4KTY1) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 415 Score = 107 bits (268), Expect = 2e-23 Identities = 65/181 (35%), Positives = 90/181 (49%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F KV + Q AIKM+D+ V E EV +R V H I+QL EV Sbjct: 89 GNFSKVVRVEHRVTKQPYAIKMIDR-----VQGKEVFESEVAVLRRVKHSYIIQLIEVFE 143 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 T++K+Y VME GGELFD++ G TE A + ++ V Y H G+ HR Sbjct: 144 TKDKVYMVMELATGGELFDRIIAKGSFTERDATRVLNMVLDGVKYLHGLGITHRDLKPEN 203 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGLS S K + + TTCGTP Y+APE+I++ Y + D+W Sbjct: 204 LLYYHPGHDSKIMITDFGLS--STRKGPENFMRTTCGTPEYIAPEIIARKPY-MCQVDMW 260 Query: 543 S 545 + Sbjct: 261 A 261
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 107 bits (267), Expect = 2e-23 Identities = 64/181 (35%), Positives = 94/181 (51%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F +V A + + A+K + K K LK G I E+ +R + H+NIV L ++ Sbjct: 32 GAFSEVVLAEEKATGKLFAVKCIPK-KALK-GKESSIENEIAVLRKIKHENIVALEDIYE 89 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 + N +Y VM+ V GGELFD++ + G TE A +Q++ AV Y H G+ HR Sbjct: 90 SPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPEN 149 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 +SDFGLS + + + ++ T CGTP YVAPEV+++ Y A D W Sbjct: 150 LLYYSQDEESKIMISDFGLSKM---EGKGDVMSTACGTPGYVAPEVLAQKPYSKA-VDCW 205 Query: 543 S 545 S Sbjct: 206 S 206
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 107 bits (267), Expect = 2e-23 Identities = 64/181 (35%), Positives = 94/181 (51%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F +V A + + A+K + K K LK G I E+ +R + H+NIV L ++ Sbjct: 32 GAFSEVVLAEEKATGKLFAVKCIPK-KALK-GKESSIENEIAVLRKIKHENIVALEDIYE 89 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 + N +Y VM+ V GGELFD++ + G TE A +Q++ AV Y H G+ HR Sbjct: 90 SPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPEN 149 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 +SDFGLS + + + ++ T CGTP YVAPEV+++ Y A D W Sbjct: 150 LLYYSQDEESKIMISDFGLSKM---EGKGDVMSTACGTPGYVAPEVLAQKPYSKA-VDCW 205 Query: 543 S 545 S Sbjct: 206 S 206
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 107 bits (266), Expect = 3e-23 Identities = 60/179 (33%), Positives = 95/179 (53%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG V+ AR ES +A+K+L K ++ K G+ Q+RREV + H NI++L+ Sbjct: 148 KGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYF 207 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 +++Y +++Y GGELF ++ K + + + Y +QL A+ YCHS+ V HR Sbjct: 208 HDASRVYLILDYAPGGELFRELQKCTRFDDQRSAMYIKQLAEALLYCHSKKVIHRDIKPE 267 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S + S R+ T CGT Y+ PE+I +D D+WS Sbjct: 268 NLLLGSNGELKIADFGWSVHAPSSRRT----TLCGTLDYLPPEMIEGRMHD-ETVDLWS 321
>KCC1G_RAT (Q7TNJ7) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 105 bits (263), Expect = 6e-23 Identities = 59/181 (32%), Positives = 91/181 (50%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F +V + + + A+K + K + + E+ ++ + H+NIV L ++ Sbjct: 32 GAFSEVFLVKQRVTGKLFALKCIKKSPAFR---DSSLENEIAVLKRIKHENIVTLEDIYE 88 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 + Y VM+ V GGELFD++ + G TE A QQ++SAV Y H G+ HR Sbjct: 89 STTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPEN 148 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGLS + Q+G++ T CGTP YVAPEV+++ Y A D W Sbjct: 149 LLYLTPEENSKIMITDFGLSKM----EQNGVMSTACGTPGYVAPEVLAQKPYSKA-VDCW 203 Query: 543 S 545 S Sbjct: 204 S 204
>KCC1G_HUMAN (Q96NX5) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 105 bits (263), Expect = 6e-23 Identities = 59/181 (32%), Positives = 91/181 (50%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F +V + + + A+K + K + + E+ ++ + H+NIV L ++ Sbjct: 32 GAFSEVFLVKQRLTGKLFALKCIKKSPAFR---DSSLENEIAVLKKIKHENIVTLEDIYE 88 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 + Y VM+ V GGELFD++ + G TE A QQ++SAV Y H G+ HR Sbjct: 89 STTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPEN 148 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGLS + Q+G++ T CGTP YVAPEV+++ Y A D W Sbjct: 149 LLYLTPEENSKIMITDFGLSKM----EQNGIMSTACGTPGYVAPEVLAQKPYSKA-VDCW 203 Query: 543 S 545 S Sbjct: 204 S 204
>KCC1B_RAT (O70150) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 105 bits (263), Expect = 6e-23 Identities = 65/181 (35%), Positives = 93/181 (51%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F +V A+ S VA+K + K K L+ G + E+ +R ++H NIV L +V Sbjct: 24 GAFSEVMLAQERGSAHLVALKCIPK-KALR-GKEALVENEIAVLRRISHPNIVALEDVHE 81 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 + + +Y ME V GGELFD++ + G TE A Q++ AV Y HS G+ HR Sbjct: 82 SPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPEN 141 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 VSDFGLS + + +L T CGTP YVAPE++ + Y G D+W Sbjct: 142 LLYATPFEDSKIMVSDFGLSKI----QAGNMLGTACGTPGYVAPELLEQKPY-GKAVDVW 196 Query: 543 S 545 + Sbjct: 197 A 197
>KCC1B_MOUSE (Q9QYK9) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 105 bits (263), Expect = 6e-23 Identities = 65/181 (35%), Positives = 93/181 (51%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F +V A+ S VA+K + K K L+ G + E+ +R ++H NIV L +V Sbjct: 24 GAFSEVMLAQERGSAHLVALKCIPK-KALR-GKEALVENEIAVLRRISHPNIVALEDVHE 81 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 + + +Y ME V GGELFD++ + G TE A Q++ AV Y HS G+ HR Sbjct: 82 SPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPEN 141 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 VSDFGLS + + +L T CGTP YVAPE++ + Y G D+W Sbjct: 142 LLYATPFEDSKIMVSDFGLSKI----QAGNMLGTACGTPGYVAPELLEQKPY-GKAVDVW 196 Query: 543 S 545 + Sbjct: 197 A 197
>KCC1G_MOUSE (Q91VB2) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 477 Score = 105 bits (263), Expect = 6e-23 Identities = 59/181 (32%), Positives = 91/181 (50%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F +V + + + A+K + K + + E+ ++ + H+NIV L ++ Sbjct: 32 GAFSEVFLVKQRVTGKLFALKCIKKSPAFR---DSSLENEIAVLKRIKHENIVTLEDIYE 88 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 + Y VM+ V GGELFD++ + G TE A QQ++SAV Y H G+ HR Sbjct: 89 STTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPEN 148 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGLS + Q+G++ T CGTP YVAPEV+++ Y A D W Sbjct: 149 LLYLTPEENSKIMITDFGLSKM----EQNGVMSTACGTPGYVAPEVLAQKPYSKA-VDCW 203 Query: 543 S 545 S Sbjct: 204 S 204
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 105 bits (262), Expect = 8e-23 Identities = 66/183 (36%), Positives = 101/183 (55%), Gaps = 5/183 (2%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKE--KVLKVGLSEQIRREVTTMRLVAHKNIVQLHEV 185 GTFG V A++ E+ + VA+K+L K+ K KV L E + E+ ++ + H NIV + Sbjct: 46 GTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQL-EALYDELDILQRLHHPNIVAFKDW 104 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX--- 356 +++K Y + + KGGELFD++ K GK TE A + +++SAV Y HSQ + HR Sbjct: 105 FESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVRILVEILSAVKYMHSQNIVHRDLKP 164 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 V+DFG++ K + LL+ G+ YVAPEV+++ G+ G D Sbjct: 165 ENLLYIDKSDESPLVVADFGIA--KRLKSDEELLYKPAGSLGYVAPEVLTQDGH-GKPCD 221 Query: 537 IWS 545 IWS Sbjct: 222 IWS 224
>KCC1B_HUMAN (Q6P2M8) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase) Length = 343 Score = 105 bits (262), Expect = 8e-23 Identities = 65/181 (35%), Positives = 93/181 (51%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F +V A+ S VA+K + K K L+ G + E+ +R ++H NIV L +V Sbjct: 24 GAFSEVVLAQERGSAHLVALKCIPK-KALR-GKEALVENEIAVLRRISHPNIVALEDVHE 81 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 + + +Y ME V GGELFD++ + G TE A Q++ AV Y HS G+ HR Sbjct: 82 SPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPEN 141 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 VSDFGLS + + +L T CGTP YVAPE++ + Y G D+W Sbjct: 142 LLYATPFEDSKIMVSDFGLSKI----QAGNMLGTACGTPGYVAPELLEQKPY-GKAVDVW 196 Query: 543 S 545 + Sbjct: 197 A 197
>KPSH1_MOUSE (Q91YA2) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 105 bits (262), Expect = 8e-23 Identities = 64/181 (35%), Positives = 94/181 (51%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+F +V + Q AIKM++ + + G E E+ +R V H NI+QL EV Sbjct: 106 GSFSRVVRVEHRATRQPYAIKMIETK--YREG-REVCESELRVLRRVRHANIIQLVEVFE 162 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 T+ ++Y VME GGELFD++ G TE A + Q ++ V Y H+ G+ HR Sbjct: 163 TQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPEN 222 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGL A + K D L+ TTCGTP Y+APEV+ + Y + D+W Sbjct: 223 LLYYHPGTDSKIIITDFGL-ASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNS-VDMW 280 Query: 543 S 545 + Sbjct: 281 A 281
>KPSH1_HUMAN (P11801) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 105 bits (262), Expect = 8e-23 Identities = 64/181 (35%), Positives = 94/181 (51%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+F +V + Q AIKM++ + + G E E+ +R V H NI+QL EV Sbjct: 106 GSFSRVVRVEHRATRQPYAIKMIETK--YREG-REVCESELRVLRRVRHANIIQLVEVFE 162 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 T+ ++Y VME GGELFD++ G TE A + Q ++ V Y H+ G+ HR Sbjct: 163 TQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPEN 222 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGL A + K D L+ TTCGTP Y+APEV+ + Y + D+W Sbjct: 223 LLYYHPGTDSKIIITDFGL-ASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNS-VDMW 280 Query: 543 S 545 + Sbjct: 281 A 281
>TSSK1_MOUSE (Q61241) Testis-specific serine/threonine-protein kinase 1 (EC| 2.7.11.1) (TSSK-1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A) Length = 364 Score = 105 bits (261), Expect = 1e-22 Identities = 64/182 (35%), Positives = 94/182 (51%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG++ KV A S +VA+K++D++K L + + RE+ + ++ H++IV+ +E+ Sbjct: 20 EGSYAKVKSAYSERLKFNVAVKIIDRKKAPSDFLEKFLPREIEILAMLNHRSIVKTYEIF 79 Query: 189 ATRN-KIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 AT + K+Y VME G+L + + G L E A K F QL SA+ YCH V HR Sbjct: 80 ATSDGKVYIVMELGVQGDLLEFIKTRGALQEDDARKKFHQLSSAIKYCHDLDVVHRDLKS 139 Query: 366 XXXXXXXXXXXXVSDFGLS--ALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 +SDFG S L + + L T CG+ AY APEV+ Y DI Sbjct: 140 ENLLLDKDFNIKLSDFGFSKRCLRDDSGRLILSKTFCGSAAYAAPEVLQGIPYQPKVYDI 199 Query: 540 WS 545 WS Sbjct: 200 WS 201
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 104 bits (260), Expect = 1e-22 Identities = 56/179 (31%), Positives = 95/179 (53%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FGKV+ + E+ A+K ++K+++++ + +Q RREV HKN+ QL+ Sbjct: 108 KGKFGKVYCVKHRETGLICALKAMEKKEIVQYTIQKQFRREVEIQGSFKHKNLTQLYGFF 167 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++Y +MEYV GEL+ + +G L E A + Q+ +A+DY HS+ + HR Sbjct: 168 YDEKRVYLLMEYVYYGELYKFLKNNGPLNETLASYFVYQMANALDYMHSKNILHRDIKPE 227 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S +E ++ T CGT Y++PE+I Y+ K D+W+ Sbjct: 228 NILIGFNNTIKLTDFGWSVYNEDGQK---RKTLCGTIDYLSPELIKSREYNN-KVDVWA 282
>KPSH1_BRARE (Q501V0) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 422 Score = 104 bits (259), Expect = 2e-22 Identities = 63/181 (34%), Positives = 92/181 (50%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+F +V + Q AIKM++ + G E E+ +R V H NI+QL EV Sbjct: 105 GSFSRVVRVEHRSTRQPYAIKMIETR--YREG-REVCESELCVLRRVRHTNIIQLMEVFE 161 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 T ++Y VME GGELFD++ G TE A + Q ++ V Y H+ G+ HR Sbjct: 162 TAERVYMVMELATGGELFDRIITRGSFTERDATRVLQMVLDGVKYLHTLGITHRDLKPEN 221 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGL A + K + L+ TTCGTP Y+APE++ + Y A D+W Sbjct: 222 LLYYHPGADSKIMITDFGL-ASTRKKGDECLMKTTCGTPEYIAPEILVRKPYTNA-VDMW 279 Query: 543 S 545 + Sbjct: 280 A 280
>PK2_DICDI (P28178) Protein kinase 2 (EC 2.7.11.1)| Length = 479 Score = 103 bits (258), Expect = 2e-22 Identities = 58/179 (32%), Positives = 97/179 (54%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G+FGKV + ++ A+K+L K+ ++ + E T ++ ++H IV LH Sbjct: 161 KGSFGKVMQVKKKGEDKIFAMKVLRKDAIIARKQVNHTKSEKTILQCISHPFIVNLHYAF 220 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T++K+Y V+++V GGELF + + G+ +E Y +++SA+D+ H Q + +R Sbjct: 221 QTKDKLYMVLDFVNGGELFFHLKREGRFSEPRVKIYAAEIVSALDHLHKQDIVYRDLKPE 280 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGLS E+ DG T CGTP Y+APEV++ G+ G D WS Sbjct: 281 NILLDSEGHICITDFGLSKKIET--TDGTF-TFCGTPEYLAPEVLNGHGH-GCAVDWWS 335
>KAPCG_HUMAN (P22612) cAMP-dependent protein kinase, gamma-catalytic subunit (EC| 2.7.11.11) (PKA C-gamma) Length = 350 Score = 103 bits (258), Expect = 2e-22 Identities = 62/178 (34%), Positives = 93/178 (52%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V R E+ A+K+L+K+KV+K+ E I E ++ + +V+L Sbjct: 52 GSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F ++ + G+ +E A Y Q++ AV Y HS + HR Sbjct: 112 DNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDQQGYLQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>KCC1A_HUMAN (Q14012) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 370 Score = 103 bits (257), Expect = 3e-22 Identities = 61/181 (33%), Positives = 90/181 (49%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F +V A + + VAIK + KE + G + E+ + + H NIV L ++ Sbjct: 29 GAFSEVILAEDKRTQKLVAIKCIAKEAL--EGKEGSMENEIAVLHKIKHPNIVALDDIYE 86 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 + +Y +M+ V GGELFD++ + G TE A + Q++ AV Y H G+ HR Sbjct: 87 SGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPEN 146 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 +SDFGLS + + +L T CGTP YVAPEV+++ Y A D W Sbjct: 147 LLYYSLDEDSKIMISDFGLSKMED---PGSVLSTACGTPGYVAPEVLAQKPYSKA-VDCW 202 Query: 543 S 545 S Sbjct: 203 S 203
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 103 bits (257), Expect = 3e-22 Identities = 61/182 (33%), Positives = 101/182 (55%), Gaps = 4/182 (2%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQ-IRREVTTMRLVAHKNIVQLHEVM 188 G+FG V AR L +N+ VAIK+L K+ + + Q + E++ ++ ++H NIV + Sbjct: 56 GSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLSHPNIVSFKDWF 115 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---X 359 +++K Y V + GGELFD++ GK TE A + Q++ AV+Y HS+ V HR Sbjct: 116 ESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPE 175 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFG++ + K ++ L++ G+ YVAPEV+++ G+ G DI Sbjct: 176 NVLYVDKSENSPLVIADFGIA--KQLKGEEDLIYKAAGSLGYVAPEVLTQDGH-GKPCDI 232 Query: 540 WS 545 WS Sbjct: 233 WS 234
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 103 bits (256), Expect = 4e-22 Identities = 62/188 (32%), Positives = 94/188 (50%), Gaps = 10/188 (5%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVG----LSEQIRREVTTMRLVAHKNIVQLH 179 GTF V A + S + AIK+++K K+L +E +RE+ ++ + H +VQ H Sbjct: 176 GTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDILKSLHHPGVVQCH 235 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 E+ ++++ VMEYV+GG+L D + +G + E +QL+ + + H QGV HR Sbjct: 236 EIFENDDELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLLETLLHLHKQGVTHRDI 295 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKT------GYD 521 +SDFGL+ + L T CGT Y+APEV+ GYD Sbjct: 296 KPENILITNDFHLKISDFGLAKVIHG--TGTFLETFCGTMGYLAPEVLKSKNVNLDGGYD 353 Query: 522 GAKSDIWS 545 K DIWS Sbjct: 354 D-KVDIWS 360
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 102 bits (255), Expect = 5e-22 Identities = 58/179 (32%), Positives = 92/179 (51%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG V+ AR +S +A+K+L K ++ K G+ Q+RREV + H NI++L+ Sbjct: 141 KGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYF 200 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++Y ++EY G ++ ++ K K E Y +L +A+ YCHS+ V HR Sbjct: 201 HDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPE 260 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S + S R+ T CGT Y+ PE+I +D K D+WS Sbjct: 261 NLLLGSAGELKIADFGWSVHAPSSRRT----TLCGTLDYLPPEMIEGRMHD-EKVDLWS 314
>TSSK1_HUMAN (Q9BXA7) Testis-specific serine/threonine-protein kinase 1 (EC| 2.7.11.1) (TSSK-1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A) Length = 367 Score = 102 bits (253), Expect = 9e-22 Identities = 62/182 (34%), Positives = 91/182 (50%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG++ KV A S +VAIK++D++K L + + RE+ + ++ H +I++ +E+ Sbjct: 20 EGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIF 79 Query: 189 ATRN-KIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T + K+Y VME G+L + + G L E A K F QL A+ YCH V HR Sbjct: 80 ETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKC 139 Query: 366 XXXXXXXXXXXXVSDFGLS--ALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 +SDF S L + + L T CG+PAY APEV+ Y DI Sbjct: 140 DNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDI 199 Query: 540 WS 545 WS Sbjct: 200 WS 201
>KCC1A_RAT (Q63450) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 102 bits (253), Expect = 9e-22 Identities = 60/181 (33%), Positives = 90/181 (49%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F +V A + + VAIK + K+ + G + E+ + + H NIV L ++ Sbjct: 29 GAFSEVILAEDKRTQKLVAIKCIAKKAL--EGKEGSMENEIAVLHKIKHPNIVALDDIYE 86 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 + +Y +M+ V GGELFD++ + G TE A + Q++ AV Y H G+ HR Sbjct: 87 SGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPEN 146 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 +SDFGLS + + +L T CGTP YVAPEV+++ Y A D W Sbjct: 147 LLYYSLDEDSKIMISDFGLSKMED---PGSVLSTACGTPGYVAPEVLAQKPYSKA-VDCW 202 Query: 543 S 545 S Sbjct: 203 S 203
>KCC1A_MOUSE (Q91YS8) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 102 bits (253), Expect = 9e-22 Identities = 60/181 (33%), Positives = 90/181 (49%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G F +V A + + VAIK + K+ + G + E+ + + H NIV L ++ Sbjct: 29 GAFSEVILAEDKRTQKLVAIKCIAKKAL--EGKEGSMENEIAVLHKIKHPNIVALDDIYE 86 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 + +Y +M+ V GGELFD++ + G TE A + Q++ AV Y H G+ HR Sbjct: 87 SGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPEN 146 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 +SDFGLS + + +L T CGTP YVAPEV+++ Y A D W Sbjct: 147 LLYYSLDEDSKIMISDFGLSKMED---PGSVLSTACGTPGYVAPEVLAQKPYSKA-VDCW 202 Query: 543 S 545 S Sbjct: 203 S 203
>KAPCA_BOVIN (P00517) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 101 bits (252), Expect = 1e-21 Identities = 59/178 (33%), Positives = 91/178 (51%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + +E+ A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDQQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 101 bits (251), Expect = 2e-21 Identities = 54/180 (30%), Positives = 97/180 (53%), Gaps = 1/180 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G+F V+ A S+ + VAIKM+DK+ + K G+ ++++ EV + H +I++L+ Sbjct: 20 KGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYF 79 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGK-LTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 N +Y V+E GE+ + K +E A + Q+I+ + Y HS G+ HR Sbjct: 80 EDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTL 139 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL+ ++ K +T CGTP Y++PE+ +++ + G +SD+WS Sbjct: 140 SNLLLTRNMNIKIADFGLA--TQLKMPHEKHYTLCGTPNYISPEIATRSAH-GLESDVWS 196
>KAPCA_RAT (P27791) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 101 bits (251), Expect = 2e-21 Identities = 60/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + ES A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDQQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>KAPCA_MOUSE (P05132) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 101 bits (251), Expect = 2e-21 Identities = 60/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + ES A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDQQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 101 bits (251), Expect = 2e-21 Identities = 56/165 (33%), Positives = 86/165 (52%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG V+ AR +S VA+K+L K ++ K G+ Q+RRE+ + H NI+QL+ Sbjct: 88 KGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYF 147 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 + +IY ++EY GEL+ ++ KSG E ++L A+ YCH + V HR Sbjct: 148 YDQQRIYLILEYAPRGELYKELQKSGTFDEQRTATIMEELSDALMYCHKKKVIHRDIKPE 207 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVI 503 ++DFG S + S R+ T CGT Y+ PE+I Sbjct: 208 NLLLGLQGELKIADFGWSVHAPSLRR----KTMCGTLDYLPPEMI 248
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 100 bits (250), Expect = 2e-21 Identities = 58/179 (32%), Positives = 91/179 (50%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG V+ AR +S +A+K+L K ++ K G+ Q+RREV + H NI++L+ Sbjct: 134 KGKFGNVYLAREKQSKFILALKVLFKVQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYF 193 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++Y ++EY G ++ ++ K K E Y +L +A+ YCHS+ V HR Sbjct: 194 HDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPE 253 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S + S R+ T CGT Y PE+I +D K D+WS Sbjct: 254 NLLLGSNGELKIADFGWSVHAPSSRRT----TLCGTLDYQPPEMIEGRMHD-EKVDLWS 307
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 100 bits (250), Expect = 2e-21 Identities = 56/178 (31%), Positives = 92/178 (51%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+VH RS+ + + AIK+L K++V+K+ E E ++LV H ++++ Sbjct: 79 GSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQ 138 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 I+ VM+Y++GGELF + KS + A Y ++I A++Y H+ + +R Sbjct: 139 DARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPEN 198 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG +K + T CGTP Y+APEVI+ Y+ D WS Sbjct: 199 ILLDRNGHIKITDFGF-----AKEVQTVTWTLCGTPDYIAPEVITTKPYN-KSVDWWS 250
>KPK19_ARATH (Q39030) Serine/threonine-protein kinase AtPK19 (EC 2.7.11.1)| (Ribosomal-protein S6 kinase homolog) Length = 471 Score = 100 bits (250), Expect = 2e-21 Identities = 53/179 (29%), Positives = 97/179 (54%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FGKV+ R ++++ A+K++ K+K+++ +E ++ E + + H IVQL Sbjct: 148 QGAFGKVYQVRKKDTSEIYAMKVMRKDKIVEKNHAEYMKAERDILTKIDHPFIVQLKYSF 207 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T+ ++Y V++++ GG LF ++ G E A Y +++SAV + H +G+ HR Sbjct: 208 QTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGIMHRDLKPE 267 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL+ E + ++ CGT Y+APE++ G+D A +D WS Sbjct: 268 NILMDVDGHVMLTDFGLAKEFEENTRS---NSMCGTTEYMAPEIVRGKGHDKA-ADWWS 322
>STK33_HUMAN (Q9BYT3) Serine/threonine-protein kinase 33 (EC 2.7.11.1)| Length = 514 Score = 100 bits (249), Expect = 3e-21 Identities = 64/188 (34%), Positives = 94/188 (50%), Gaps = 9/188 (4%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G+FG V A E+ AIK ++KEK + + + REV ++ V H++I+ L +V Sbjct: 124 KGSFGIVIEATDKETETKWAIKKVNKEKAGSSAV-KLLEREVNILKSVKHEHIIHLEQVF 182 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----- 353 T K+Y VME + GEL + + + G +E Q L SA+ Y H+ + HR Sbjct: 183 ETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLE 242 Query: 354 ----XXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYD 521 V+DFGL A+ + R + +L TCGTP Y+APEVIS Y Sbjct: 243 NIMVKSSLIDDNNEINLNIKVTDFGL-AVKKQSRSEAMLQATCGTPIYMAPEVISAHDY- 300 Query: 522 GAKSDIWS 545 + DIWS Sbjct: 301 SQQCDIWS 308
>KAPB2_BOVIN (P24256) cAMP-dependent protein kinase, beta-2-catalytic subunit| (EC 2.7.11.11) (PKA C-beta-2) Length = 397 Score = 100 bits (249), Expect = 3e-21 Identities = 59/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + + Q A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 99 GSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFK 158 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 159 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 218 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 219 LLIDHQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 270
>AURKB_HUMAN (Q96GD4) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1) (Aurora-B) Length = 344 Score = 100 bits (249), Expect = 3e-21 Identities = 58/178 (32%), Positives = 92/178 (51%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG V+ AR +S+ VA+K+L K ++ K G+ Q+RRE+ + H NI++L+ Sbjct: 85 KGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYF 144 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 R +IY ++EY GEL+ ++ KS E ++L A+ YCH + V HR Sbjct: 145 YDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPE 204 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFG S + S R+ T CGT Y+ PE+I ++ K D+W Sbjct: 205 NLLLGLKGELKIADFGWSVHAPSLRR----KTMCGTLDYLPPEMIEGRMHN-EKVDLW 257
>KAPCB_HUMAN (P22694) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 100 bits (249), Expect = 3e-21 Identities = 59/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + + Q A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDHQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>KAPCA_SHEEP (Q9MZD9) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 100 bits (249), Expect = 3e-21 Identities = 59/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + E+ A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHTETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDQQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>KAPCA_PIG (P36887) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 100 bits (249), Expect = 3e-21 Identities = 59/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + E+ A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDQQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>KAPB1_BOVIN (P05131) cAMP-dependent protein kinase, beta-1-catalytic subunit| (EC 2.7.11.11) (PKA C-beta-1) Length = 350 Score = 100 bits (249), Expect = 3e-21 Identities = 59/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + + Q A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDHQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 100 bits (248), Expect = 4e-21 Identities = 57/179 (31%), Positives = 91/179 (50%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG V+ AR +S +A+K+L K ++ K + Q+RREV + H NI++L+ Sbjct: 132 KGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHPNILRLYGYF 191 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++Y ++EY G ++ ++ K K E Y +L +A+ YCHS+ V HR Sbjct: 192 HDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPE 251 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG S + S R+ T CGT Y+ PE+I +D K D+WS Sbjct: 252 NLLLGSNGELKIADFGWSVHAPSSRRT----TMCGTLDYLPPEMIEGRMHD-EKVDLWS 305
>KAPCA_CANFA (Q8MJ44) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 349 Score = 100 bits (248), Expect = 4e-21 Identities = 59/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + E+ A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 51 GSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFK 110 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 111 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 170 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 171 LLIDQQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 222
>KAPCB_RAT (P68182) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 100 bits (248), Expect = 4e-21 Identities = 59/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + + Q A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDHQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>KAPCB_MOUSE (P68181) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 100 bits (248), Expect = 4e-21 Identities = 59/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + + Q A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDHQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>KAPCB_CRIGR (P68180) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 100 bits (248), Expect = 4e-21 Identities = 59/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + + Q A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDHQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>KAPCA_HUMAN (P17612) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 100 bits (248), Expect = 4e-21 Identities = 59/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + E+ A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDQQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>KAPCA_CRIGR (P25321) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 100 bits (248), Expect = 4e-21 Identities = 59/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + E+ A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDQQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>KPK1_ARATH (P42818) Serine/threonine-protein kinase AtPK1/AtPK6 (EC 2.7.11.1)| Length = 465 Score = 100 bits (248), Expect = 4e-21 Identities = 53/179 (29%), Positives = 96/179 (53%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FGKV+ R E+++ A+K++ K+ +++ +E ++ E + + H IVQL Sbjct: 142 KGAFGKVYQVRKKETSEIYAMKVMRKDHIMEKNHAEYMKAERDILTKIDHPFIVQLKYSF 201 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T+ ++Y V++++ GG LF ++ G E A Y +++SAV + H +G+ HR Sbjct: 202 QTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGIMHRDLKPE 261 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL+ E + ++ CGT Y+APE++ G+D A +D WS Sbjct: 262 NILMDTDGHVMLTDFGLAKEFEENTRS---NSMCGTTEYMAPEIVRGKGHDKA-ADWWS 316
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 99.8 bits (247), Expect = 5e-21 Identities = 52/179 (29%), Positives = 91/179 (50%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FGKV+ + ++ A+K ++K+++++ + +Q RREV + H N+++L Sbjct: 107 KGKFGKVYLVKDKKTGFVSALKCMEKKELVEGNVEKQFRREVEIQSNLRHTNVLRLFGHF 166 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++++Y ++EYV GEL+ + + TE A Y Q+ A+ Y H + + HR Sbjct: 167 HDKDRVYLILEYVVHGELYKLLRNQKRFTESTASSYIYQMSEALLYLHGKNIIHRDIKPE 226 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 +SDFG S + S R+ T CGT Y+ PE++ YD D+WS Sbjct: 227 NILLHFNDTIKISDFGWSVHAPSNRRS----TLCGTMDYLPPEIVQSRPYD-KNVDVWS 280
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 99.8 bits (247), Expect = 5e-21 Identities = 54/181 (29%), Positives = 92/181 (50%), Gaps = 2/181 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG+V+ R +ES A+K ++K+ +++ + +Q RREV + H N+ QL+ Sbjct: 117 KGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQFRREVEIQSSLRHPNLTQLYGYF 176 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++Y +MEY+ GEL+ + + A Y Q+ A+DY H + + HR Sbjct: 177 HDEKRVYLLMEYLVNGELYKHLKGRSHFNDVVASYYVYQMADALDYMHERNILHRDIKPE 236 Query: 369 XXXXXXXXXXXVSDFGLSALSE--SKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFG S ++ SKR+ T CGT Y++PE+I Y+ K D+W Sbjct: 237 NIIIGFNNTIKLTDFGWSVITPKGSKRK-----TLCGTVDYLSPELIRSREYN-EKVDVW 290 Query: 543 S 545 + Sbjct: 291 A 291
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 99.8 bits (247), Expect = 5e-21 Identities = 53/180 (29%), Positives = 95/180 (52%), Gaps = 1/180 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G+F V+ A S+ + VAIKM+DK+ + K G+ ++++ EV + H ++++L+ Sbjct: 20 KGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYF 79 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGK-LTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 N +Y V+E GE+ + K +E A + Q+I+ + Y HS G+ HR Sbjct: 80 EDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTL 139 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL+ + +T CGTP Y++PE+ +++ + G +SDIWS Sbjct: 140 SNILLTRNMNIKIADFGLATQLNMPHEKH--YTLCGTPNYISPEIATRSAH-GLESDIWS 196
>KCC1_SCHPO (Q9P7I2) Calcium/calmodulin-dependent protein kinase type I (EC| 2.7.11.17) (CaMK-I) Length = 335 Score = 99.4 bits (246), Expect = 6e-21 Identities = 61/183 (33%), Positives = 92/183 (50%), Gaps = 5/183 (2%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVA--HKNIVQLHEV 185 GT+ V A +E+N+ A K+++K+ + K + ++ E+ ++ V+ H NI+ L + Sbjct: 40 GTYATVREAVHIETNKMYAAKIMNKKMMEKK--QDFVKNEIAILKRVSYEHPNILHLVDF 97 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX--- 356 T N +Y + E GGELFD++ G E A + SAV Y H G+ HR Sbjct: 98 FETVNNLYLITELATGGELFDRICAKGSFYEADAAALMRTTTSAVKYLHDNGIVHRDLKP 157 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 ++DFGLS E Q +L T CGTP Y+APEV +TGY G D Sbjct: 158 ENLLYRSKDPNSDLLIADFGLSHFYEDS-QYYMLMTACGTPEYMAPEVFRRTGY-GKPVD 215 Query: 537 IWS 545 +W+ Sbjct: 216 MWA 218
>KAPCB_PIG (P05383) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 99.4 bits (246), Expect = 6e-21 Identities = 59/178 (33%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + + Q A+K+LDK+KV+K+ E E ++ V +V+L Sbjct: 52 GSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEFSFK 111 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ +Y HS + +R Sbjct: 112 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 171 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 172 LLIDHQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 223
>SGK1_RAT (Q06226) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 430 Score = 99.0 bits (245), Expect = 8e-21 Identities = 61/181 (33%), Positives = 91/181 (50%), Gaps = 1/181 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTM-RLVAHKNIVQLHEV 185 +G+FGKV AR A+K+L K+ +LK + I E + + V H +V LH Sbjct: 106 KGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFS 165 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T +K+YFV++Y+ GGELF + + E A Y ++ SA+ Y HS + +R Sbjct: 166 FQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKP 225 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL E+ +G T CGTP Y+APEV+ K YD ++ W Sbjct: 226 ENILLDSQGHIVLTDFGL--CKENIEHNGTTSTFCGTPEYLAPEVLHKQPYD--RTVDWW 281 Query: 546 C 548 C Sbjct: 282 C 282
>SGK1_RABIT (Q9XT18) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 99.0 bits (245), Expect = 8e-21 Identities = 61/181 (33%), Positives = 91/181 (50%), Gaps = 1/181 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTM-RLVAHKNIVQLHEV 185 +G+FGKV AR A+K+L K+ +LK + I E + + V H +V LH Sbjct: 106 KGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFS 165 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T +K+YFV++Y+ GGELF + + E A Y ++ SA+ Y HS + +R Sbjct: 166 FQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKP 225 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL E+ +G T CGTP Y+APEV+ K YD ++ W Sbjct: 226 ENILLDSQGHIVLTDFGL--CKENIEHNGTTSTFCGTPEYLAPEVLHKQPYD--RTVDWW 281 Query: 546 C 548 C Sbjct: 282 C 282
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 99.0 bits (245), Expect = 8e-21 Identities = 55/165 (33%), Positives = 85/165 (51%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG V+ AR +S VA+K+L K ++ K G+ Q+RRE+ + H NI+QL+ Sbjct: 90 KGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYF 149 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 + +IY ++EY GEL+ ++ KS E ++L A+ YCH + V HR Sbjct: 150 YDQQRIYLILEYAPRGELYKELQKSRTFDEQRTATIMEELSDALTYCHKKKVIHRDIKPE 209 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVI 503 ++DFG S + S R+ T CGT Y+ PE+I Sbjct: 210 NLLLGLQGELKIADFGWSVHAPSLRR----KTMCGTLDYLPPEMI 250
>KRAC_DICDI (P54644) RAC-family serine/threonine-protein kinase homolog (EC| 2.7.11.1) Length = 444 Score = 99.0 bits (245), Expect = 8e-21 Identities = 59/185 (31%), Positives = 95/185 (51%), Gaps = 6/185 (3%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G+FGKV R ++ + A+K+L K+ +++ E E ++ + H +V L+ Sbjct: 128 KGSFGKVIQVRKKDTGEVYAMKVLSKKHIVEHNEVEHTLSERNILQKINHPFLVNLNYSF 187 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +K+YF+++YV GGELF + K K TE Y +++ A+++ H GV +R Sbjct: 188 QTEDKLYFILDYVNGGELFYHLQKDKKFTEDRVRYYGAEIVLALEHLHLSGVIYRDLKPE 247 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTT------CGTPAYVAPEVISKTGYDGAK 530 ++DFGL ++GLL T CGTP Y+APEV+ GY G + Sbjct: 248 NLLLTNEGHICMTDFGLC-------KEGLLTPTDKTGTFCGTPEYLAPEVLQGNGY-GKQ 299 Query: 531 SDIWS 545 D WS Sbjct: 300 VDWWS 304
>KAPC_DICDI (P34099) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) Length = 648 Score = 99.0 bits (245), Expect = 8e-21 Identities = 54/178 (30%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 GTFGKV+ ++ + A+K L+K V+++ E + E + + + H IV L++ Sbjct: 345 GTFGKVYLIQNTKDGCYYAMKCLNKAYVVQLKQVEHLNSEKSILSSIHHPFIVNLYQAFQ 404 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 K+Y + EYV GGE+F + KS K + A Y +++ A+++ H Q + +R Sbjct: 405 DEKKLYLLFEYVAGGEVFTHLRKSMKFSNSTAKFYAAEIVLALEFLHKQNIVYRDLKPEN 464 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG +KR + T CGTP Y+APE+I G+ G D W+ Sbjct: 465 LLIDNQGHIKITDFGF-----AKRVEDRTFTLCGTPEYLAPEIIQSKGH-GKAVDWWA 516
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 98.6 bits (244), Expect = 1e-20 Identities = 54/179 (30%), Positives = 95/179 (53%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG+V+ A+ ++ VA+K L K ++++ + +Q+RRE+ + HKNI++L+ Sbjct: 97 KGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKNILRLYGHF 156 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 +IY ++E+ GEL+ + ++ + +E A KY Q+ +A+ Y H + V HR Sbjct: 157 HDEKRIYLILEFAGRGELYQHLRRAKRFSEEVASKYIFQMANALSYLHKKHVIHRDIKPE 216 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 +SDFG S + S R+ T CGT Y+ PE++ + K D+WS Sbjct: 217 NILLGIDGEIKLSDFGWSVHAPSNRRT----TLCGTLDYLPPEMVEGKEHT-EKVDLWS 270
>SGK1_MOUSE (Q9WVC6) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 98.6 bits (244), Expect = 1e-20 Identities = 61/181 (33%), Positives = 91/181 (50%), Gaps = 1/181 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTM-RLVAHKNIVQLHEV 185 +G+FGKV AR A+K+L K+ +LK + I E + + V H +V LH Sbjct: 106 KGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFS 165 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T +K+YFV++Y+ GGELF + + E A Y ++ SA+ Y HS + +R Sbjct: 166 FQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKP 225 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL E+ +G T CGTP Y+APEV+ K YD ++ W Sbjct: 226 ENILLDSQGHIVLTDFGL--CKENIEHNGTTSTFCGTPEYLAPEVLHKQPYD--RTVDWW 281 Query: 546 C 548 C Sbjct: 282 C 282
>CDR1_SCHPO (P07334) Mitosis inducer protein kinase cdr1 (EC 2.7.11.1) (Protein| kinase nim1) Length = 593 Score = 98.6 bits (244), Expect = 1e-20 Identities = 56/190 (29%), Positives = 91/190 (47%), Gaps = 8/190 (4%) Frame = +3 Query: 3 RHEGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSE-------QIRREVTTMRLVAHK 161 RH+ T G ++L + + +++ K + + I E+ MRL+ H Sbjct: 4 RHKNTIGVWRLGKTLGTGSTSCVRLAKHAKTGDLAAIKIIPIRYASIGMEILMMRLLRHP 63 Query: 162 NIVQLHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQG 341 NI++L++V +Y +EYV GELF + K G L+E A Y Q++ AV +CH Sbjct: 64 NILRLYDVWTDHQHMYLALEYVPDGELFHYIRKHGPLSEREAAHYLSQILDAVAHCHRFR 123 Query: 342 VYHR-XXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGY 518 HR ++DFG++ + + D L CG+ Y+APE++S Y Sbjct: 124 FRHRDLKLENILIKVNEQQIKIADFGMATVEPN---DSCLENYCGSLHYLAPEIVSHKPY 180 Query: 519 DGAKSDIWSC 548 GA +D+WSC Sbjct: 181 RGAPADVWSC 190
>TSSK2_HUMAN (Q96PF2) Testis-specific serine/threonine-protein kinase 2 (EC| 2.7.11.1) (TSSK-2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G) Length = 358 Score = 98.6 bits (244), Expect = 1e-20 Identities = 61/182 (33%), Positives = 92/182 (50%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G++ KV A S +VA+K++D++K + + RE+ + V H +I++ +E+ Sbjct: 20 KGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIF 79 Query: 189 ATRN-KIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T + +IY +ME G+L + + G L E A K F+QL SAV YCH + HR Sbjct: 80 ETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKC 139 Query: 366 XXXXXXXXXXXXVSDFGLS--ALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 +SDFG S L +S + L T CG+ AY APEV+ Y DI Sbjct: 140 ENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDI 199 Query: 540 WS 545 WS Sbjct: 200 WS 201
>PLK2_MOUSE (P53351) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 98.2 bits (243), Expect = 1e-20 Identities = 58/182 (31%), Positives = 91/182 (50%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F K + L +N+ A K++ +V K E+I +E+ RL+ HK++VQ + Sbjct: 87 KGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRLLHHKHVVQFYHYF 146 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 + IY ++EY + + LTE Y +Q++S + Y H Q + HR Sbjct: 147 EDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLG 206 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLH---TTCGTPAYVAPEVISKTGYDGAKSDI 539 V DFGL+A R + L H T CGTP Y++PEV++K G+ G +SDI Sbjct: 207 NFFINEAMELKVGDFGLAA-----RLEPLEHRRRTICGTPNYLSPEVLNKQGH-GCESDI 260 Query: 540 WS 545 W+ Sbjct: 261 WA 262
>TSSK4_MOUSE (Q9D411) Testis-specific serine/threonine-protein kinase 4 (EC| 2.7.11.1) (TSSK-4) (Testis-specific kinase 4) (TSK-4) Length = 328 Score = 98.2 bits (243), Expect = 1e-20 Identities = 53/191 (27%), Positives = 97/191 (50%), Gaps = 13/191 (6%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G++G V+ A + VA+K++ K+K + L++ + RE+ M+++ HK ++ ++ + Sbjct: 34 GSYGTVYEAYYTKQKVMVAVKIISKKKASEDYLNKFLPREIQVMKVLRHKYLINFYQAIE 93 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 T +++Y ++E +GG++ + + + G E A K+F Q+ + Y HS+G+ HR Sbjct: 94 TTSRVYIILELAQGGDVLEWIQRYGACAETLAGKWFSQMALGIAYLHSKGIVHRDLKLEN 153 Query: 372 XXXXXXXXXXVSDFGLSAL---------SESKRQ----DGLLHTTCGTPAYVAPEVISKT 512 +SDFG + + S S RQ L T CG+ AY PE++ Sbjct: 154 LLLDKRENVKISDFGFAKMVPSSQPVHSSPSYRQMNSLSHLSQTYCGSFAYACPEILLGL 213 Query: 513 GYDGAKSDIWS 545 Y+ SD WS Sbjct: 214 PYNPFLSDTWS 224
>KIN1_YEAST (P13185) Protein kinase KIN1 (EC 2.7.11.1)| Length = 1064 Score = 97.8 bits (242), Expect = 2e-20 Identities = 58/204 (28%), Positives = 98/204 (48%), Gaps = 26/204 (12%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKM------------------------LDKEKVLKVGLSEQ 119 G+ GKV A+ +N+ A+K+ L+++K L+ +S Sbjct: 129 GSMGKVKLAKHRYTNEVCAVKIVNRATKAFLHKEQMLPPPKNEQDVLERQKKLEKEISRD 188 Query: 120 IR--REVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHK 293 R RE + +++ H +I +L E+ N Y + EYV GG+L D + + G + E A K Sbjct: 189 KRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQARK 248 Query: 294 YFQQLISAVDYCHSQGVYHRXXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCG 473 + + + SA+ Y H+ + HR + DFGLS + +S++Q LHT CG Sbjct: 249 FARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQ---LHTFCG 305 Query: 474 TPAYVAPEVISKTGYDGAKSDIWS 545 + + APE++ Y G + D+WS Sbjct: 306 SLYFAAPELLKANPYTGPEVDVWS 329
>PLK2_HUMAN (Q9NYY3) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 685 Score = 97.4 bits (241), Expect = 2e-20 Identities = 57/182 (31%), Positives = 91/182 (50%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F K + L +N+ A K++ +V K E+I +E+ R++ HK++VQ + Sbjct: 90 KGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYF 149 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 + IY ++EY + + LTE Y +Q++S + Y H Q + HR Sbjct: 150 EDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLG 209 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLH---TTCGTPAYVAPEVISKTGYDGAKSDI 539 V DFGL+A R + L H T CGTP Y++PEV++K G+ G +SDI Sbjct: 210 NFFINEAMELKVGDFGLAA-----RLEPLEHRRRTICGTPNYLSPEVLNKQGH-GCESDI 263 Query: 540 WS 545 W+ Sbjct: 264 WA 265
>PLK2_RAT (Q9R012) Serine/threonine-protein kinase PLK2 (EC 2.7.11.21)| (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) Length = 682 Score = 97.4 bits (241), Expect = 2e-20 Identities = 57/182 (31%), Positives = 91/182 (50%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F K + L +N+ A K++ +V K E+I +E+ R++ HK++VQ + Sbjct: 87 KGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYF 146 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 + IY ++EY + + LTE Y +Q++S + Y H Q + HR Sbjct: 147 EDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLG 206 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLH---TTCGTPAYVAPEVISKTGYDGAKSDI 539 V DFGL+A R + L H T CGTP Y++PEV++K G+ G +SDI Sbjct: 207 NFFINEAMELKVGDFGLAA-----RLEPLEHRRRTICGTPNYLSPEVLNKQGH-GCESDI 260 Query: 540 WS 545 W+ Sbjct: 261 WA 262
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 97.4 bits (241), Expect = 2e-20 Identities = 58/182 (31%), Positives = 98/182 (53%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQS---VAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLH 179 +G+FGKV R + S A+K+L K+ LKV ++ + E + ++H IV+LH Sbjct: 112 QGSFGKVFLVRKVRGRDSGHVYAMKVL-KKATLKVRDRQRTKLERNILAHISHPFIVKLH 170 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T K+Y ++++++GG+LF +++K TE Y +L A+++ HS G+ +R Sbjct: 171 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDL 230 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 V+DFGLS E+ + ++ CGT Y+APEVI++ G+ A +D Sbjct: 231 KPENILLDADGHIKVTDFGLS--KEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMA-ADF 287 Query: 540 WS 545 WS Sbjct: 288 WS 289 Score = 76.6 bits (187), Expect = 4e-14 Identities = 49/157 (31%), Positives = 74/157 (47%), Gaps = 5/157 (3%) Frame = +3 Query: 90 KVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVKGGELFDKVAKSGK 269 K++K + + +R H+ +V+L +V IY + E +GGEL DK+ Sbjct: 483 KIVKKAVFDATEEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKS 542 Query: 270 L-TEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXXXXXXXX----XXXXVSDFGLSALSE 434 L +E L++AV Y HSQ V HR + DFG + + Sbjct: 543 LGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFA--KQ 600 Query: 435 SKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 S+ ++G+L T C T +VAPEV+ K GYD D+WS Sbjct: 601 SRAENGMLMTPCYTAQFVAPEVLRKQGYD-RSCDVWS 636
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 97.1 bits (240), Expect = 3e-20 Identities = 52/181 (28%), Positives = 92/181 (50%), Gaps = 2/181 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FGKV+ R + A+K+++KE+++K L +Q RREV + H N+ + + Sbjct: 112 KGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLNHPNLTKSYGYF 171 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++Y +MEY+ GE++ + G + A Y Q+ +A+DY H + + HR Sbjct: 172 HDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYMHKKNIIHRDIKPE 231 Query: 369 XXXXXXXXXXXVSDFGLSALS--ESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFG S ++ E++R+ T CGT Y++PE++ YD D W Sbjct: 232 NILIGFNNVIKLTDFGWSIINPPENRRK-----TVCGTIDYLSPEMVESREYDHT-IDAW 285 Query: 543 S 545 + Sbjct: 286 A 286
>KK31_SCHPO (Q9HFF4) Probable serine/threonine-protein kinase C110.01 (EC| 2.7.11.1) Length = 1023 Score = 96.7 bits (239), Expect = 4e-20 Identities = 67/200 (33%), Positives = 99/200 (49%), Gaps = 21/200 (10%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLS-------EQIRREVTTMRLVA--HKN 164 G FGKV L S I + V+K+ LS ++ REV ++ + H + Sbjct: 501 GEFGKVKLGWPLPKANST-IHRSTPQVVIKIVLSTKQNCQTSRLMREVAILKGLGNNHPH 559 Query: 165 IVQLHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGV 344 IV+ + + T++ V++YV GGELFD + +L + A + F QLIS V Y HS+GV Sbjct: 560 IVKYLDFVKTKHHFGIVLDYVNGGELFDYILARRRLEDSVACRLFAQLISGVAYLHSRGV 619 Query: 345 YHRXXXXXXXXXXXXXXXXVSDFG----------LSALSESKRQDGLLHTTCGTPAYVAP 494 HR ++DFG LS S + L T+CG+P Y AP Sbjct: 620 VHRDLKLENILLDTNRNIVIADFGFATTFGHFNTLSEHSLPTEKPDLFSTSCGSPCYAAP 679 Query: 495 EVIS-KTG-YDGAKSDIWSC 548 E+++ K+G Y G ++DIWSC Sbjct: 680 ELVNCKSGMYAGTQADIWSC 699
>KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC 2.7.11.11) (PKA| 1) (CDC25-suppressing protein kinase) (PK-25) Length = 397 Score = 96.7 bits (239), Expect = 4e-20 Identities = 54/178 (30%), Positives = 91/178 (51%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+VH RS + + A+K+L KE V+++ E E + +V H I+++ Sbjct: 96 GSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQ 155 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 +I+ +M+Y++GGELF + KS + A Y ++ A++Y HS+ + +R Sbjct: 156 DAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPEN 215 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG +K + +T CGTP Y+APEV+S Y+ D WS Sbjct: 216 ILLDKNGHIKITDFGF-----AKYVPDVTYTLCGTPDYIAPEVVSTKPYN-KSIDWWS 267
>LOK_DROME (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC| 2.7.11.1) (Protein loki) (dMNK) Length = 476 Score = 96.3 bits (238), Expect = 5e-20 Identities = 56/189 (29%), Positives = 96/189 (50%), Gaps = 11/189 (5%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLS------EQIRREVTTMRLVAHKNIVQ 173 G +G V + Q A+K++ K + S +++ E M+ ++H +V+ Sbjct: 183 GAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVR 242 Query: 174 LHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR 353 +H+++ + +Y V+E+++GG+L +++ + L+E + YF Q+ AV Y H +G+ HR Sbjct: 243 MHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHR 302 Query: 354 X---XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDG 524 VSDFGLS + +D ++ T CGTP YVAPEV+ G + Sbjct: 303 DLKPDNVLLETNDEETLLKVSDFGLSKFVQ---KDSVMRTLCGTPLYVAPEVLITGGREA 359 Query: 525 --AKSDIWS 545 K DIWS Sbjct: 360 YTKKVDIWS 368
>SGK1_HUMAN (O00141) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 96.3 bits (238), Expect = 5e-20 Identities = 60/181 (33%), Positives = 90/181 (49%), Gaps = 1/181 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTM-RLVAHKNIVQLHEV 185 +G+FGKV AR A+K+L K+ +LK + I E + + V H +V LH Sbjct: 106 KGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFS 165 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T +K+YFV++Y+ GGELF + + E A Y ++ SA+ Y HS + +R Sbjct: 166 FQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKP 225 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL E+ + T CGTP Y+APEV+ K YD ++ W Sbjct: 226 ENILLDSQGHIVLTDFGL--CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD--RTVDWW 281 Query: 546 C 548 C Sbjct: 282 C 282
>KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC 2.7.11.11) (PKA| 3) Length = 398 Score = 95.9 bits (237), Expect = 7e-20 Identities = 53/178 (29%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+VH RS + + A+K L K ++K+ E E + +V+H I+++ Sbjct: 97 GSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQ 156 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 +++ VM+Y++GGELF + KS + A Y ++ A++Y HS+ + +R Sbjct: 157 DSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPEN 216 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG +K + +T CGTP Y+APEV+S Y+ D WS Sbjct: 217 ILLDKNGHIKITDFGF-----AKYVPDVTYTLCGTPDYIAPEVVSTKPYN-KSVDWWS 268
>KAPC_CAEEL (P21137) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 404 Score = 95.5 bits (236), Expect = 9e-20 Identities = 53/178 (29%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + +S A+K+LDK+KV+K+ E E ++ + +V + Sbjct: 90 GSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDFPFLVNMTFSFK 149 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y V+E++ GGE+F + + G+ +E + Y Q++ A +Y HS + +R Sbjct: 150 DNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPEN 209 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 210 LLIDSTGYLKITDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 261
>CHK1_SCHPO (P34208) Serine/threonine-protein kinase chk1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 496 Score = 95.1 bits (235), Expect = 1e-19 Identities = 55/184 (29%), Positives = 93/184 (50%), Gaps = 5/184 (2%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKV---LKVGL-SEQIRREVTTMRLV-AHKNIVQL 176 G F V ++ + A+K ++K+ + G+ + ++ E+ +L HKNI+ Sbjct: 19 GAFASVRLCYD-DNAKIYAVKFVNKKHATSCMNAGVWARRMASEIQLHKLCNGHKNIIHF 77 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX 356 + + V+E+ +GG+LFDK+ + E A YF QL+ + + HS+GV HR Sbjct: 78 YNTAENPQWRWVVLEFAQGGDLFDKIEPDVGIDEDVAQFYFAQLMEGISFMHSKGVAHRD 137 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 +SDFG ++L K + LL++ G+P Y APE+ + YDG+K D Sbjct: 138 LKPENILLDYNGNLKISDFGFASLFSYKGKSRLLNSPVGSPPYAAPEITQQ--YDGSKVD 195 Query: 537 IWSC 548 +WSC Sbjct: 196 VWSC 199
>KPC2_APLCA (Q16975) Calcium-independent protein kinase C (EC 2.7.11.13) (APL| II) Length = 743 Score = 95.1 bits (235), Expect = 1e-19 Identities = 54/183 (29%), Positives = 95/183 (51%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVA----HKNIVQL 176 +G+FGKV A +++ AIK+L K+ +++ + + +T R++A H + L Sbjct: 411 KGSFGKVMLAEKKGTDEVYAIKVLKKDVIIQ---DDDVECTMTEKRILALSAKHPFLTAL 467 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX 356 H T+ +++FVMEYV GG+L ++ ++ K E A Y ++ A+ + H G+ +R Sbjct: 468 HSSFQTKERLFFVMEYVNGGDLMFQIQRARKFDEPRARFYAAEVTLALMFLHRHGIIYRD 527 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 ++DFG+ E ++ L T CGTP Y+APE++ + YD A D Sbjct: 528 LKLDNILLDAEGHCKIADFGM--CKEGMTENKLTQTFCGTPDYIAPEILQELKYD-ASVD 584 Query: 537 IWS 545 W+ Sbjct: 585 WWA 587
>YP150_YEAST (Q12152) Putative serine/threonine-protein kinase YPL150W (EC| 2.7.11.1) Length = 901 Score = 95.1 bits (235), Expect = 1e-19 Identities = 59/179 (32%), Positives = 86/179 (48%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG+FGKV+ A +++ V +K DK I REV R I +L+EV+ Sbjct: 49 EGSFGKVYLALHRPTHRKVCLKTSDKN-------DPNIVREVFYHRQFDFPYITKLYEVI 101 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +K++ +EY G EL+D + +++ + F Q+ AV Y HS HR Sbjct: 102 VTESKVWMALEYCPGKELYDHLLSLRRISLLECGELFAQISGAVYYAHSMHCVHRDLKLE 161 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG + +K L T CGT Y+APE+I + YDG K DIWS Sbjct: 162 NILLDKNGNAKLTDFGFTRECMTKT---TLETVCGTTVYMAPELIERRTYDGFKIDIWS 217
>KIN2_YEAST (P13186) Serine/threonine-protein kinase KIN2 (EC 2.7.11.1)| Length = 1147 Score = 95.1 bits (235), Expect = 1e-19 Identities = 54/175 (30%), Positives = 93/175 (53%), Gaps = 2/175 (1%) Frame = +3 Query: 27 VHFARSLESNQSVAIKMLDKEKVLKVGLSEQIR--REVTTMRLVAHKNIVQLHEVMATRN 200 +H SL S ++ + ++L+++K L+ ++ R RE + +++ H +I +L E+ N Sbjct: 138 LHKQHSLPSPKNES-EILERQKRLEKEIARDKRTVREASLGQILYHPHICRLFEMCTMSN 196 Query: 201 KIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXXXXX 380 Y + EYV GG+L D + + G L E A K+ + + SA+ Y H+ + HR Sbjct: 197 HFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMI 256 Query: 381 XXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFGLS + + ++Q LHT CG+ + APE++ Y G + DIWS Sbjct: 257 SSSGEIKIIDFGLSNIFDYRKQ---LHTFCGSLYFAAPELLKAQPYTGPEVDIWS 308
>KAPC_DROME (P12370) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 352 Score = 95.1 bits (235), Expect = 1e-19 Identities = 56/178 (31%), Positives = 88/178 (49%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+FG+V + + A+K+LDK+KV+K+ E E ++ + +V L Sbjct: 54 GSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLVSLRYHFK 113 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y V+EYV GGE+F + K G+ +E + Y Q++ A +Y H + +R Sbjct: 114 DNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPEN 173 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 V+DFG +KR G T CGTP Y+APE+I GY+ A D W+ Sbjct: 174 LLIDSQGYLKVTDFGF-----AKRVKGRTWTLCGTPEYLAPEIILSKGYNKA-VDWWA 225
>IPL1_CANGA (Q6FV07) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 358 Score = 95.1 bits (235), Expect = 1e-19 Identities = 55/181 (30%), Positives = 94/181 (51%), Gaps = 2/181 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FGKV+ R +S A+K ++K ++L+ L +Q++REV + H NI++L+ Sbjct: 108 KGKFGKVYCVRHKKSGFICALKAIEKNEILQFNLLKQLKREVDIQLGMDHPNIIKLYAHF 167 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 ++Y +ME+ GEL+ + +G + A Y Q+ A+ Y H + + HR Sbjct: 168 HDEKRVYLLMEHSINGELYKSLKNNGPFNDVLASHYIYQIADALHYMHKKRIIHRDVKPE 227 Query: 369 XXXXXXXXXXXVSDFGLSALSE--SKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFG S L+ SKR+ T CGT Y++PE+I+ YD + D+W Sbjct: 228 NVLIGFDNVVKLADFGWSILNPEGSKRK-----TLCGTIDYLSPEMITPREYD-EQVDVW 281 Query: 543 S 545 + Sbjct: 282 A 282
>STK11_HUMAN (Q15831) Serine/threonine-protein kinase 11 (EC 2.7.11.1)| (Serine/threonine-protein kinase LKB1) (NY-REN-19 antigen) Length = 433 Score = 94.7 bits (234), Expect = 1e-19 Identities = 59/185 (31%), Positives = 96/185 (51%), Gaps = 6/185 (3%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSE-QIRREVTTMRLVAHKNIVQLHEV 185 EG++GKV E+ A+K+L K+K+ ++ E +++E+ +R + HKN++QL +V Sbjct: 57 EGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDV 116 Query: 186 MAT--RNKIYFVMEYVKGG--ELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR 353 + + K+Y VMEY G E+ D V + + AH YF QLI ++Y HSQG+ H+ Sbjct: 117 LYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLIDGLEYLHSQGIVHK 175 Query: 354 XXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTG-YDGAK 530 +SD G++ D T+ G+PA+ PE+ + + G K Sbjct: 176 DIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFK 235 Query: 531 SDIWS 545 DIWS Sbjct: 236 VDIWS 240
>TSSK4_HUMAN (Q6SA08) Testis-specific serine/threonine-protein kinase 4 (EC| 2.7.11.1) (TSSK-4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E) Length = 328 Score = 94.7 bits (234), Expect = 1e-19 Identities = 50/191 (26%), Positives = 94/191 (49%), Gaps = 13/191 (6%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G++G V+ A + VA+K++ K+K L++ + RE+ M+++ HK ++ + + Sbjct: 34 GSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIE 93 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +++Y ++E +GG++ + + + G +E A K+F QL + Y HS+ + HR Sbjct: 94 STSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLEN 153 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDG-------------LLHTTCGTPAYVAPEVISKT 512 +SDFG + + S + G L T CG+ AY PE++ Sbjct: 154 LLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGL 213 Query: 513 GYDGAKSDIWS 545 Y+ SD WS Sbjct: 214 PYNPFLSDTWS 224
>KPC1_APLCA (Q16974) Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I)| Length = 649 Score = 94.4 bits (233), Expect = 2e-19 Identities = 56/183 (30%), Positives = 94/183 (51%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKN----IVQL 176 +G+FGKV A +++ AIK+L K+ +++ + + + R++A + +VQL Sbjct: 328 KGSFGKVVLAERKGTDELYAIKILKKDVIIQ---DDDVECTMIEKRVLALPDKPPFLVQL 384 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX 356 H T +++YFVMEYV GG+L ++ + GK E A Y ++ + Y H+QG+ +R Sbjct: 385 HSCFQTMDRLYFVMEYVNGGDLMYRIQQEGKFKEPVAAFYAAEIAIGLFYLHTQGIVYRD 444 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 ++DFG+ E+ D T CGTP Y+APE++ Y G D Sbjct: 445 LKLDNVMLDAEGHIKIADFGM--CKENIMGDKTTRTFCGTPDYIAPEIVLYQPY-GRSVD 501 Query: 537 IWS 545 W+ Sbjct: 502 WWA 504
>KCC4_MOUSE (P08414) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 469 Score = 94.4 bits (233), Expect = 2e-19 Identities = 55/156 (35%), Positives = 83/156 (53%), Gaps = 4/156 (2%) Frame = +3 Query: 90 KVLKVGLSEQI-RREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVKGGELFDKVAKSG 266 KVLK + ++I R E+ + ++H NI++L E+ T +I V+E V GGELFD++ + G Sbjct: 71 KVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKG 130 Query: 267 KLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XXXXXXXXXXXXXXXVSDFGLSALSES 437 +E A +Q++ AV Y H G+ HR ++DFGLS + E Sbjct: 131 YYSERDARDAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE- 189 Query: 438 KRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 L+ T CGTP Y APE++ Y G + D+WS Sbjct: 190 --HQVLMKTVCGTPGYCAPEILRGCAY-GPEVDMWS 222
>CDPK3_PLAF7 (Q9NJU9) Calcium-dependent protein kinase 3 (EC 2.7.11.1) (PfCDPK3)| Length = 562 Score = 94.4 bits (233), Expect = 2e-19 Identities = 60/182 (32%), Positives = 92/182 (50%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GT+G V+ A S A+K++ K+K+ + + R+E+ M+ + H N+V+L E Sbjct: 126 KGTYGCVYKATDKLLKISRAVKVVSKKKLKNI---PRFRQEIDIMKNLDHPNVVKLLETF 182 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---X 359 N+IY VME GGELFDK+ K G E A +Q+ S ++Y H + + HR Sbjct: 183 EDSNQIYLVMELCTGGELFDKIVKKGCFVETFASFIMKQIFSVLNYLHIRNICHRDIKPE 242 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 + DFGL++ + + T GTP YVAP+V+ TG K D+ Sbjct: 243 NFLFYDMTPESLIKIIDFGLASYFTHNNYE--MKTKAGTPYYVAPQVL--TGSYNYKCDM 298 Query: 540 WS 545 WS Sbjct: 299 WS 300
>ZYG1_CAEBR (Q621J7) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 709 Score = 94.4 bits (233), Expect = 2e-19 Identities = 61/183 (33%), Positives = 93/183 (50%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G FG V+ A+ E+ + VAIK K+ +I+ E+ TM+L+ H+NIVQ +E Sbjct: 21 QGGFGVVYSAQR-ENGEKVAIK-----KIGNAASQTRIKEEIKTMKLLRHRNIVQFYETF 74 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 + Y VME +GG L D V + G L + A +QLI+AV Y H + + HR Sbjct: 75 FENGETYLVMELCEGGSLMDYVKQKGPLDDSTAVHILRQLIAAVKYIHDENILHRDLSAG 134 Query: 369 XXXXXXXXXXXVS----DFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 ++ DFGL+ + Q G T GTP ++AP+V + YD A +D Sbjct: 135 NVFIKDATKSTITVKLGDFGLAT---NLGQHGTACTIVGTPGFIAPQVFGQ-NYDQA-AD 189 Query: 537 IWS 545 ++S Sbjct: 190 VYS 192
>CRK_DAUCA (P53681) CDPK-related protein kinase (EC 2.7.11.1) (PK421)| Length = 602 Score = 94.0 bits (232), Expect = 3e-19 Identities = 60/185 (32%), Positives = 91/185 (49%), Gaps = 5/185 (2%) Frame = +3 Query: 6 HEGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMR-LVAHKNIVQLHE 182 H G + F + Q VA+K++ K K+ E +RREV +R L H N+VQ ++ Sbjct: 158 HFGYTCRAKFKKGEFKGQDVAVKVIPKAKMTTAIAIEDVRREVKILRALTGHNNLVQFYD 217 Query: 183 VMATRNKIYFVMEYVKGGELFDKV-AKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX- 356 +Y VME +GGEL D++ ++ GK TE A Q+++ V +CH QGV HR Sbjct: 218 AFEDHTNVYVVMELCEGGELLDRILSRGGKYTEDDAKAVMIQILNVVAFCHLQGVVHRDL 277 Query: 357 --XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAK 530 DFG LS+ + D L+ G+ YVAPEV+ ++ + Sbjct: 278 KPENFLFKSKDEDSQLKAIDFG---LSDYVKPDERLNDIVGSAYYVAPEVLHRS--YSTE 332 Query: 531 SDIWS 545 +D+WS Sbjct: 333 ADVWS 337
>SGK2_HUMAN (Q9HBY8) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) Length = 427 Score = 94.0 bits (232), Expect = 3e-19 Identities = 59/181 (32%), Positives = 86/181 (47%), Gaps = 1/181 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTM-RLVAHKNIVQLHEV 185 +G +GKV A+ A+K+L K+ +LK I E + + + V H +V L Sbjct: 103 KGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYS 162 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T K+YFV++YV GGELF + + + E A Y ++ SA+ Y HS + +R Sbjct: 163 FQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKP 222 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL E + T CGTP Y+APEV+ K YD A W Sbjct: 223 ENILLDCQGHVVLTDFGL--CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVD--WW 278 Query: 546 C 548 C Sbjct: 279 C 279
>AKT2_RAT (P47197) RAC-beta serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta) Length = 481 Score = 93.6 bits (231), Expect = 3e-19 Identities = 58/181 (32%), Positives = 89/181 (49%), Gaps = 3/181 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVA---HKNIVQLH 179 +GTFGKV R + + A+K+L KE ++ +++ VT R++ H + L Sbjct: 160 KGTFGKVILVREKATGRYYAMKILRKEVIIA---KDEVAHTVTESRVLQNTRHPFLTALK 216 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T +++ FVMEY GG+LF +++ TE A Y +++SA++Y HS V +R Sbjct: 217 YAFQTHDRLCFVMEYANGGDLFFHLSRERVFTEDRARFYGAEIVSALEYLHSTDVVYRDI 276 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGLS E + T CGTP Y+APEV+ Y G D Sbjct: 277 KLENLMLDKDGHIKITDFGLS--KEGISDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDW 333 Query: 540 W 542 W Sbjct: 334 W 334
>AKT2_MOUSE (Q60823) RAC-beta serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta) Length = 481 Score = 93.6 bits (231), Expect = 3e-19 Identities = 58/181 (32%), Positives = 89/181 (49%), Gaps = 3/181 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVA---HKNIVQLH 179 +GTFGKV R + + A+K+L KE ++ +++ VT R++ H + L Sbjct: 160 KGTFGKVILVREKATGRYYAMKILRKEVIIA---KDEVAHTVTESRVLQNTRHPFLTALK 216 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T +++ FVMEY GGELF +++ TE A Y +++SA++Y HS+ V +R Sbjct: 217 YAFQTHDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDI 276 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGL E + T CGTP Y+APEV+ Y G D Sbjct: 277 KLENLMLDKDGHIKITDFGL--CKEGISDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDW 333 Query: 540 W 542 W Sbjct: 334 W 334
>KIN1_SCHPO (P22987) Protein kinase kin1 (EC 2.7.11.1)| Length = 891 Score = 93.6 bits (231), Expect = 3e-19 Identities = 60/197 (30%), Positives = 93/197 (47%), Gaps = 19/197 (9%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDK-------------EKVLKVGLSEQIRREVTTMR-- 146 G+ GKV A L++ + AIK++ + + K SE+ +E+ T+R Sbjct: 134 GSMGKVKVAHHLKTGEQFAIKIVTRLHPDITKAKAAASAEATKAAQSEK-NKEIRTVREA 192 Query: 147 ----LVAHKNIVQLHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLIS 314 L+ H I + +V T + Y V E+V GG++ D + GKL E A K+ +Q+ S Sbjct: 193 ALSTLLRHPYICEARDVYITNSHYYMVFEFVDGGQMLDYIISHGKLKEKQARKFVRQIGS 252 Query: 315 AVDYCHSQGVYHRXXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAP 494 A+ Y H V HR + DFGLS L R+ L T CG+ + AP Sbjct: 253 ALSYLHQNSVVHRDLKIENILISKTGDIKIIDFGLSNL---YRRQSRLRTFCGSLYFAAP 309 Query: 495 EVISKTGYDGAKSDIWS 545 E+++ Y G + D+WS Sbjct: 310 ELLNAQPYIGPEVDVWS 326
>PLK3_CAEEL (Q20845) Serine/threonine-protein kinase plk-3 (EC 2.7.11.21)| (Polo-like kinase 3) Length = 615 Score = 93.6 bits (231), Expect = 3e-19 Identities = 56/179 (31%), Positives = 85/179 (47%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG F R L+ N +A+K++ K +LK E++ REV R ++H+NIVQ H Sbjct: 43 EGGFAHCFEFRKLDCNDRLAVKVVPKVILLKSTAREKLTREVEIHRQLSHRNIVQFHHFF 102 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 +YF +E L + + G LTE A Y Q+ V + H+ + HR Sbjct: 103 EDSQNVYFTLELCSKNSLMELNKQRGPLTEHEARFYTIQVAEGVKHLHNLQIIHRDLKLG 162 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFGL+ E + T GTP Y+APEV+++TG+ + DIW+ Sbjct: 163 NLFLNEHLQVKIGDFGLATFCEKNEKK---MTRGGTPNYIAPEVLNETGH-AFEVDIWA 217
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 93.6 bits (231), Expect = 3e-19 Identities = 56/182 (30%), Positives = 98/182 (53%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSL---ESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLH 179 +G+FGKV R + ++NQ A+K+L K+ LKV + + E + V H +V+LH Sbjct: 70 QGSFGKVFLVRKITPPDANQLYAMKVL-KKATLKVRDRVRTKMERDILADVHHPFVVRLH 128 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T K+Y ++++++GG+LF +++K TE Y +L +D+ HS G+ +R Sbjct: 129 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 188 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGLS E+ + ++ CGT Y+APEV+++ G+ + +D Sbjct: 189 KPENILLDEEGHIKLTDFGLS--KEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHS-ADW 245 Query: 540 WS 545 WS Sbjct: 246 WS 247 Score = 80.5 bits (197), Expect = 3e-15 Identities = 56/169 (33%), Positives = 79/169 (46%), Gaps = 4/169 (2%) Frame = +3 Query: 51 SNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVK 230 +N A+K++DK K SE+I R H NI+ L +V N IY V E ++ Sbjct: 438 TNMEYAVKVIDKTKR---DPSEEIE---ILRRYGQHPNIIALKDVYKEGNSIYVVTELMR 491 Query: 231 GGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----XXXXXXXXXXXXXXX 398 GGEL D++ + +E A + V+ HSQGV HR Sbjct: 492 GGELLDRILRQKFFSEREASSVLFTVCKTVENLHSQGVVHRDLKPSNILYVDESGDPESI 551 Query: 399 XVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFG + + + +GLL T C T +VAPEV+ + GYD DIWS Sbjct: 552 RICDFGFA--KQLRADNGLLMTPCYTANFVAPEVLKRQGYDEG-CDIWS 597
>KDC2_DROME (P16912) Protein kinase DC2 (EC 2.7.11.1)| Length = 583 Score = 93.6 bits (231), Expect = 3e-19 Identities = 52/178 (29%), Positives = 90/178 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 GTFG+V R S + A+K+L +V+++ E ++ E +R + H ++ L Sbjct: 283 GTFGRVCLCRDRISEKYCAMKILAMTEVIRLKQIEHVKNERNILREIRHPFVISLEWSTK 342 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y + +YV GGELF + +GK T ++ Y +++SA++Y HS + +R Sbjct: 343 DDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAAEIVSALEYLHSLQIVYRDLKPEN 402 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG +K+ T CGTP Y+APE+I G++ A D W+ Sbjct: 403 LLINRDGHLKITDFGF-----AKKLRDRTWTLCGTPEYIAPEIIQSKGHNKA-VDWWA 454
>KCC4_HUMAN (Q16566) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 473 Score = 93.6 bits (231), Expect = 3e-19 Identities = 55/156 (35%), Positives = 83/156 (53%), Gaps = 4/156 (2%) Frame = +3 Query: 90 KVLKVGLSEQI-RREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVKGGELFDKVAKSG 266 KVLK + ++I R E+ + ++H NI++L E+ T +I V+E V GGELFD++ + G Sbjct: 75 KVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKG 134 Query: 267 KLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XXXXXXXXXXXXXXXVSDFGLSALSES 437 +E A +Q++ AV Y H G+ HR ++DFGLS + E Sbjct: 135 YYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE- 193 Query: 438 KRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 L+ T CGTP Y APE++ Y G + D+WS Sbjct: 194 --HQVLMKTVCGTPGYCAPEILRGCAY-GPEVDMWS 226
>KPSH2_HUMAN (Q96QS6) Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2)| Length = 385 Score = 93.6 bits (231), Expect = 3e-19 Identities = 59/181 (32%), Positives = 92/181 (50%), Gaps = 3/181 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G+F +V + + AIK+++ + + G E E++ +R V+H+ IVQL E+ Sbjct: 72 GSFSRVVRVEQKTTKKPFAIKVMETRE--REG-REACVSELSVLRRVSHRYIVQLMEIFE 128 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XX 362 T +++Y VME GGELFD++ G TE A + Q + + Y H+ + HR Sbjct: 129 TEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPEN 188 Query: 363 XXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGL A S K D + T CGTP Y+APEV+ + Y A D+W Sbjct: 189 LLYYHPGEESKILITDFGL-AYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSA-VDMW 246 Query: 543 S 545 + Sbjct: 247 A 247
>KCC4_RAT (P13234) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) (Calspermin) Length = 474 Score = 93.6 bits (231), Expect = 3e-19 Identities = 55/156 (35%), Positives = 83/156 (53%), Gaps = 4/156 (2%) Frame = +3 Query: 90 KVLKVGLSEQI-RREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVKGGELFDKVAKSG 266 KVLK + ++I R E+ + ++H NI++L E+ T +I V+E V GGELFD++ + G Sbjct: 71 KVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKG 130 Query: 267 KLTEGAAHKYFQQLISAVDYCHSQGVYHRX---XXXXXXXXXXXXXXXVSDFGLSALSES 437 +E A +Q++ AV Y H G+ HR ++DFGLS + E Sbjct: 131 YYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE- 189 Query: 438 KRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 L+ T CGTP Y APE++ Y G + D+WS Sbjct: 190 --HQVLMKTVCGTPGYCAPEILRGCAY-GPEVDMWS 222
>KAPCG_MACMU (O62846) cAMP-dependent protein kinase, gamma-catalytic subunit (EC| 2.7.11.11) (PKA C-gamma) (Fragment) Length = 208 Score = 93.6 bits (231), Expect = 3e-19 Identities = 53/163 (32%), Positives = 82/163 (50%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 G++G+V R E+ A+K+LDK+KV+++ E E ++ + +V+L Sbjct: 51 GSYGRVMLVRHRETGNHYAMKILDKQKVVRLKQVEHTLNEKRILQAINFPFLVKLQFSFK 110 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 + +Y VMEYV GGE+F + + G+ +E A Y Q++ A Y HS + HR Sbjct: 111 DNSNLYLVMEYVPGGEMFSHLRRVGRFSEPQACFYAAQVVLAFQYLHSLDLIHRDLKPEN 170 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEV 500 V+DFG +KR G T CGTP Y+APE+ Sbjct: 171 LLIDQQGYLQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEI 208
>AKT1_DROME (Q8INB9) RAC serine/threonine-protein kinase (EC 2.7.11.1)| (DRAC-PK) (Akt) (Dakt1) (Protein kinase B) (PKB) Length = 611 Score = 93.6 bits (231), Expect = 3e-19 Identities = 59/178 (33%), Positives = 84/178 (47%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GTFGKV R + + AIK+L KE +++ E ++ H ++ L Sbjct: 274 KGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSF 333 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +++ FVM+YV GGELF ++ TE Y ++ISA+ Y HSQG+ +R Sbjct: 334 QTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLE 393 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 V+DFGL E T CGTP Y+APEV+ Y G D W Sbjct: 394 NLLLDKDGHIKVADFGL--CKEDITYGRTTKTFCGTPEYLAPEVLDDNDY-GQAVDWW 448
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 93.2 bits (230), Expect = 4e-19 Identities = 58/184 (31%), Positives = 91/184 (49%), Gaps = 4/184 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G+FG+V +R + AIK++ K+ V + E + REV ++++ H NI++L+E Sbjct: 77 KGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYEFF 136 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----X 356 N Y V + GGELFD++ + E A + +Q++S + Y H V HR Sbjct: 137 EDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPE 196 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 + DFGLS E ++ + GT Y+AP+V+ T YD K D Sbjct: 197 NILLETKNKEDMIIKIIDFGLSTHFEYSKK---MKDKIGTAYYIAPDVLHGT-YD-EKCD 251 Query: 537 IWSC 548 IWSC Sbjct: 252 IWSC 255
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 93.2 bits (230), Expect = 4e-19 Identities = 57/182 (31%), Positives = 97/182 (53%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSL---ESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLH 179 +G++GKV R + ++ Q A+K+L K+ LKV + + E + V H IV+LH Sbjct: 67 QGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDILAEVNHPFIVKLH 125 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T K+Y ++++++GG+LF +++K TE Y +L A+D+ HS G+ +R Sbjct: 126 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDL 185 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGLS E+ D ++ CGT Y+APEV+++ G+ +D Sbjct: 186 KPENILLDEEGHIKITDFGLS--KEAIDHDKRAYSFCGTIEYMAPEVVNRRGHT-QSADW 242 Query: 540 WS 545 WS Sbjct: 243 WS 244 Score = 84.7 bits (208), Expect = 2e-16 Identities = 57/164 (34%), Positives = 80/164 (48%), Gaps = 4/164 (2%) Frame = +3 Query: 66 AIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVKGGELF 245 A+K++DK K SE+I +R H NI+ L +V +Y VME ++GGEL Sbjct: 442 AVKIIDKSKR---DPSEEIE---ILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELL 495 Query: 246 DKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----XXXXXXXXXXXXXXXXVSDF 413 D++ + +E A + +DY HSQGV HR V DF Sbjct: 496 DRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDF 555 Query: 414 GLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 G + + + +GLL T C T +VAPEV+ + GYD A DIWS Sbjct: 556 GFA--KQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAA-CDIWS 596
>KS6AB_XENLA (P10666) Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1)| (Ribosomal protein S6 kinase II beta) (S6KII-beta) (P90-RSK) Length = 629 Score = 93.2 bits (230), Expect = 4e-19 Identities = 56/182 (30%), Positives = 97/182 (53%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSL---ESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLH 179 +G+FGKV R + ++NQ A+K+L K+ LKV + + E + V H +V+LH Sbjct: 70 QGSFGKVFLVRKITPPDANQLYAMKVL-KKATLKVRDRVRTKMERDILADVHHPFVVRLH 128 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T K+Y ++++++GG+LF +++K TE Y +L +D+ HS G+ +R Sbjct: 129 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 188 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGLS E+ + ++ CGT Y+APEV+++ G+ +D Sbjct: 189 KPENILLDEEGHIKLTDFGLS--KEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHG-ADW 245 Query: 540 WS 545 WS Sbjct: 246 WS 247 Score = 85.5 bits (210), Expect = 9e-17 Identities = 58/169 (34%), Positives = 81/169 (47%), Gaps = 4/169 (2%) Frame = +3 Query: 51 SNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVK 230 +N A+K++DK K SE+I R H NI+ L +V N IY V E ++ Sbjct: 438 TNMEYAVKVIDKSKR---DPSEEIE---ILRRYGQHPNIITLKDVYEECNSIYLVTELMR 491 Query: 231 GGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----XXXXXXXXXXXXXXX 398 GGEL D++ + +E A + V+Y HSQGV HR Sbjct: 492 GGELLDRILRQKFFSEREACSVLFTVCKTVEYLHSQGVVHRDLKPSNILYVDESGDPESI 551 Query: 399 XVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFG S + + ++GLL T C T +VAPEV+ + GYD DIWS Sbjct: 552 RICDFGFS--KQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG-CDIWS 597
>AKT2_HUMAN (P31751) RAC-beta serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta) Length = 481 Score = 93.2 bits (230), Expect = 4e-19 Identities = 58/181 (32%), Positives = 89/181 (49%), Gaps = 3/181 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVA---HKNIVQLH 179 +GTFGKV R + + A+K+L KE ++ +++ VT R++ H + L Sbjct: 160 KGTFGKVILVREKATGRYYAMKILRKEVIIA---KDEVAHTVTESRVLQNTRHPFLTALK 216 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T +++ FVMEY GGELF +++ TE A Y +++SA++Y HS+ V +R Sbjct: 217 YAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDI 276 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGL E + T CGTP Y+APEV+ Y G D Sbjct: 277 KLENLMLDKDGHIKITDFGL--CKEGISDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDW 333 Query: 540 W 542 W Sbjct: 334 W 334
>AKT2A_XENLA (Q7ZX15) RAC-beta serine/threonine-protein kinase-A (EC 2.7.11.1)| (RAC-PK-beta-A) (Protein kinase Akt-2-A) (Protein kinase B, beta-A) (PKB beta-A) Length = 486 Score = 93.2 bits (230), Expect = 4e-19 Identities = 56/178 (31%), Positives = 84/178 (47%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GTFGKV R + + A+K+L KE ++ E ++ H + L Sbjct: 165 KGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTLTESRVLQNTKHPFLTALKYAF 224 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +++ FVMEY GGELF +++ TE A Y +++SA++Y HS+ V +R Sbjct: 225 QTSDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRNVVYRDIKLE 284 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGL E + T CGTP Y+APEV+ Y G D W Sbjct: 285 NLMLDKDGHVKITDFGL--CKEGITDGATMRTFCGTPEYLAPEVLEDNDY-GRAVDWW 339
>AKT3_MOUSE (Q9WUA6) RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) Length = 479 Score = 92.8 bits (229), Expect = 6e-19 Identities = 56/178 (31%), Positives = 84/178 (47%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GTFGKV R S + A+K+L KE ++ E ++ H + L Sbjct: 156 KGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSF 215 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T++++ FVMEYV GGELF +++ +E Y +++SA+DY HS + +R Sbjct: 216 QTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLE 275 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGL E + T CGTP Y+APEV+ Y G D W Sbjct: 276 NLMLDKDGHIKITDFGL--CKEGITDAATMKTFCGTPEYLAPEVLEDNDY-GRAVDWW 330
>AKT3_HUMAN (Q9Y243) RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2) Length = 479 Score = 92.8 bits (229), Expect = 6e-19 Identities = 56/178 (31%), Positives = 84/178 (47%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GTFGKV R S + A+K+L KE ++ E ++ H + L Sbjct: 156 KGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSF 215 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T++++ FVMEYV GGELF +++ +E Y +++SA+DY HS + +R Sbjct: 216 QTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLE 275 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGL E + T CGTP Y+APEV+ Y G D W Sbjct: 276 NLMLDKDGHIKITDFGL--CKEGITDAATMKTFCGTPEYLAPEVLEDNDY-GRAVDWW 330
>AKT3_RAT (Q63484) RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) Length = 454 Score = 92.8 bits (229), Expect = 6e-19 Identities = 56/178 (31%), Positives = 84/178 (47%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GTFGKV R S + A+K+L KE ++ E ++ H + L Sbjct: 156 KGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSF 215 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T++++ FVMEYV GGELF +++ +E Y +++SA+DY HS + +R Sbjct: 216 QTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLE 275 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGL E + T CGTP Y+APEV+ Y G D W Sbjct: 276 NLMLDKDGHIKITDFGL--CKEGITDAATMKTFCGTPEYLAPEVLEDNDY-GRAVDWW 330
>SGK2_RAT (Q8R4U9) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) (Fragment) Length = 302 Score = 92.4 bits (228), Expect = 7e-19 Identities = 59/181 (32%), Positives = 85/181 (46%), Gaps = 1/181 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTM-RLVAHKNIVQLHEV 185 +G +GKV A+ A+K+L K+ +LK I E + + V H +V L Sbjct: 26 KGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQSHIMAERNVLLKNVRHPFLVGLRYS 85 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T K+YFV++YV GGELF + + + E A Y ++ SA+ Y HS + +R Sbjct: 86 FQTPEKLYFVLDYVNGGELFFHLQREHRFLEPRARFYTAEVASAIGYLHSLNIIYRDLKP 145 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL E + T CGTP Y+APEV+ K YD A W Sbjct: 146 ENILLDCQGHVVLTDFGL--CKECVEPEETTSTFCGTPEYLAPEVLRKEPYDRAVD--WW 201 Query: 546 C 548 C Sbjct: 202 C 202
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 92.4 bits (228), Expect = 7e-19 Identities = 50/179 (27%), Positives = 87/179 (48%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG+F V AR L +++ AIK+L+K ++K + RE M + H V+L+ Sbjct: 93 EGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTF 152 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 K+YF + Y K GEL + K G E Y +++SA++Y H +G+ HR Sbjct: 153 QDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPE 212 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG + + + + ++ GT YV+PE++++ SD+W+ Sbjct: 213 NILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS-ACKSSDLWA 270
>SGK2_MOUSE (Q9QZS5) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) Length = 367 Score = 92.4 bits (228), Expect = 7e-19 Identities = 59/181 (32%), Positives = 85/181 (46%), Gaps = 1/181 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTM-RLVAHKNIVQLHEV 185 +G +GKV A+ A+K+L K+ +LK I E + + V H +V L Sbjct: 43 KGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQNHIMAERNVLLKNVRHPFLVGLRYS 102 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T K+YFV++YV GGELF + + + E A Y ++ SA+ Y HS + +R Sbjct: 103 FQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYTAEVASAIGYLHSLNIIYRDLKP 162 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL E + T CGTP Y+APEV+ K YD A W Sbjct: 163 ENILLDCQGHVVLTDFGL--CKECVEPEETTSTFCGTPEYLAPEVLRKEPYDRAVD--WW 218 Query: 546 C 548 C Sbjct: 219 C 219
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 92.4 bits (228), Expect = 7e-19 Identities = 56/182 (30%), Positives = 96/182 (52%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSL---ESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLH 179 +G++GKV R + ++ Q A+K+L K+ LKV + + E + V H IV+LH Sbjct: 67 QGSYGKVFLVRKVTGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDILAEVNHPFIVKLH 125 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T K+Y ++++++GG+LF +++K TE Y +L A+D+ H G+ +R Sbjct: 126 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDL 185 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGLS E+ D ++ CGT Y+APEV+++ G+ +D Sbjct: 186 KPENILLDEEGHIKITDFGLS--KEATDHDKRAYSFCGTIEYMAPEVVNRRGHT-QSADW 242 Query: 540 WS 545 WS Sbjct: 243 WS 244 Score = 85.5 bits (210), Expect = 9e-17 Identities = 55/164 (33%), Positives = 81/164 (49%), Gaps = 4/164 (2%) Frame = +3 Query: 66 AIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVKGGELF 245 A+K++DK K SE+I +R H NI+ L +V +Y VME ++GGEL Sbjct: 442 AVKIIDKSKR---DPSEEIE---ILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGELL 495 Query: 246 DKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----XXXXXXXXXXXXXXXXVSDF 413 D++ + +E A + +DY HSQGV HR + DF Sbjct: 496 DRILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDF 555 Query: 414 GLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 G + + + ++GLL T C T +VAPEV+ + GYD A D+WS Sbjct: 556 GFA--KQLRAENGLLMTPCYTANFVAPEVLKRQGYDAA-CDVWS 596
>KPK2_PLAFK (Q02595) Probable serine/threonine-protein kinase 2 (EC 2.7.11.1)| Length = 510 Score = 92.4 bits (228), Expect = 7e-19 Identities = 56/182 (30%), Positives = 90/182 (49%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G+F + ++ V +K +DK KV + + E+ +R V HK I++L Sbjct: 119 KGSFSTAYIGTNILYGNRVVVKEVDKSKVKE----SNVYTEIEVLRKVMHKYIIKLISAY 174 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 +Y V+EY+KGGELF+ + +G TE A K ++++ A++ HS GV HR Sbjct: 175 EQEGFVYLVLEYLKGGELFEYLNNNGPYTEQVAKKAMKRVLIALEALHSNGVVHRDLKME 234 Query: 369 XXXX---XXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 + DFGL++ S ++ CG+P YVAPE++ Y G K DI Sbjct: 235 NLMLENPNDPSSLKIIDFGLASFLNSPS----MNMRCGSPGYVAPEILKCASY-GTKVDI 289 Query: 540 WS 545 +S Sbjct: 290 FS 291
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 92.4 bits (228), Expect = 7e-19 Identities = 57/182 (31%), Positives = 97/182 (53%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSL---ESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLH 179 +G+FGKV + + ++ Q A+K+L K+ LKV + + E + V H IV+LH Sbjct: 76 QGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDILVEVNHPFIVKLH 134 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T K+Y ++++++GG+LF +++K TE Y +L A+D+ HS G+ +R Sbjct: 135 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDL 194 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGLS ES + ++ CGT Y+APEV+++ G+ +D Sbjct: 195 KPENILLDEEGHIKLTDFGLS--KESIDHEKKAYSFCGTVEYMAPEVVNRRGHT-QSADW 251 Query: 540 WS 545 WS Sbjct: 252 WS 253 Score = 84.7 bits (208), Expect = 2e-16 Identities = 56/169 (33%), Positives = 82/169 (48%), Gaps = 4/169 (2%) Frame = +3 Query: 51 SNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVK 230 +N A+K++DK K +E+I +R H NI+ L +V +Y V E +K Sbjct: 444 TNMEFAVKIIDKSKR---DPTEEIE---ILLRYGQHPNIITLKDVYDDGKYVYVVTELMK 497 Query: 231 GGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----XXXXXXXXXXXXXXX 398 GGEL DK+ + +E A + V+Y H+QGV HR Sbjct: 498 GGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESI 557 Query: 399 XVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFG + + + ++GLL T C T +VAPEV+ + GYD A DIWS Sbjct: 558 RICDFGFA--KQLRAENGLLMTPCYTANFVAPEVLKRQGYDAA-CDIWS 603
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 92.4 bits (228), Expect = 7e-19 Identities = 57/182 (31%), Positives = 97/182 (53%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSL---ESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLH 179 +G+FGKV + + ++ Q A+K+L K+ LKV + + E + V H IV+LH Sbjct: 76 QGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDILVEVNHPFIVKLH 134 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T K+Y ++++++GG+LF +++K TE Y +L A+D+ HS G+ +R Sbjct: 135 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDL 194 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGLS ES + ++ CGT Y+APEV+++ G+ +D Sbjct: 195 KPENILLDEEGHIKLTDFGLS--KESIDHEKKAYSFCGTVEYMAPEVVNRRGHT-QSADW 251 Query: 540 WS 545 WS Sbjct: 252 WS 253 Score = 84.7 bits (208), Expect = 2e-16 Identities = 56/169 (33%), Positives = 82/169 (48%), Gaps = 4/169 (2%) Frame = +3 Query: 51 SNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVK 230 +N A+K++DK K +E+I +R H NI+ L +V +Y V E +K Sbjct: 444 TNMEFAVKIIDKSKR---DPTEEIE---ILLRYGQHPNIITLKDVYDDGKYVYVVTELMK 497 Query: 231 GGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----XXXXXXXXXXXXXXX 398 GGEL DK+ + +E A + V+Y H+QGV HR Sbjct: 498 GGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESI 557 Query: 399 XVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFG + + + ++GLL T C T +VAPEV+ + GYD A DIWS Sbjct: 558 RICDFGFA--KQLRAENGLLMTPCYTANFVAPEVLKRQGYDAA-CDIWS 603
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 92.4 bits (228), Expect = 7e-19 Identities = 50/179 (27%), Positives = 87/179 (48%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG+F V AR L +++ AIK+L+K ++K + RE M + H V+L+ Sbjct: 90 EGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTF 149 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 K+YF + Y K GEL + K G E Y +++SA++Y H +G+ HR Sbjct: 150 QDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPE 209 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG + + + + ++ GT YV+PE++++ SD+W+ Sbjct: 210 NILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS-ACKSSDLWA 267
>TSSK2_MOUSE (O54863) Testis-specific serine/threonine-protein kinase 2 (EC| 2.7.11.1) (TSSK-2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) Length = 357 Score = 92.0 bits (227), Expect = 1e-18 Identities = 60/182 (32%), Positives = 89/182 (48%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G++ KV A S +VA+K++D++K + + RE+ + V H++I++ +E+ Sbjct: 20 KGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHRSIIKTYEIF 79 Query: 189 ATRN-KIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T + +IY VME G+L + G L E K F+Q+ SAV YCH V HR Sbjct: 80 ETSDGRIYIVMELGVQGDLLTFIKCRGALHEDVGGKMFRQVSSAVKYCHDLDVVHRDLKC 139 Query: 366 XXXXXXXXXXXXVSDFGLS--ALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 +SDFG S L + + L T CG+ AY APEV Y DI Sbjct: 140 ENLLLDKDFNIKLSDFGFSKGCLRDGSGRIVLSKTFCGSAAYAAPEVRQGIPYQPKVYDI 199 Query: 540 WS 545 WS Sbjct: 200 WS 201
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 92.0 bits (227), Expect = 1e-18 Identities = 56/182 (30%), Positives = 97/182 (53%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSL---ESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLH 179 +G+FGKV R + +SN A+K+L K+ LKV + + E + V H +V+LH Sbjct: 88 QGSFGKVFLVRKITPPDSNHLYAMKVL-KKATLKVRDRVRTKIERDILADVNHPFVVKLH 146 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T K+Y ++++++GG+LF +++K TE Y +L +D+ HS G+ +R Sbjct: 147 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 206 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGLS E+ + ++ CGT Y+APEV+++ G+ + +D Sbjct: 207 KPENILLDEEGHIKLTDFGLS--KEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHS-ADW 263 Query: 540 WS 545 WS Sbjct: 264 WS 265 Score = 85.5 bits (210), Expect = 9e-17 Identities = 56/169 (33%), Positives = 81/169 (47%), Gaps = 4/169 (2%) Frame = +3 Query: 51 SNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVK 230 +N A+K++DK K SE+I +R H NI+ L +V +Y V E ++ Sbjct: 457 TNMEYAVKVIDKSKR---DPSEEIE---ILLRYGQHPNIITLKDVYDDGKYVYLVTELMR 510 Query: 231 GGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----XXXXXXXXXXXXXXX 398 GGEL DK+ + +E A + V+Y HSQGV HR Sbjct: 511 GGELLDKILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKPSNILYVDESGNPESI 570 Query: 399 XVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFG + + + ++GLL T C T +VAPEV+ + GYD DIWS Sbjct: 571 RICDFGFA--KQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG-CDIWS 616
>KS6A5_HUMAN (O75582) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL) Length = 802 Score = 92.0 bits (227), Expect = 1e-18 Identities = 59/183 (32%), Positives = 90/183 (49%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLV-AHKNIVQLHEV 185 EG+F +SNQ+ A+K++ K + ++E+T ++L H NIV+LHEV Sbjct: 434 EGSFSICRKCVHKKSNQAFAVKIISKR------MEANTQKEITALKLCEGHPNIVKLHEV 487 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX--- 356 + + VME + GGELF+++ K +E A ++L+SAV + H GV HR Sbjct: 488 FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 547 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 + DFG + L Q L T C T Y APE++++ GYD D Sbjct: 548 ENLLFTDENDNLEIKIIDFGFARLKPPDNQP--LKTPCFTLHYAAPELLNQNGYD-ESCD 604 Query: 537 IWS 545 +WS Sbjct: 605 LWS 607 Score = 75.5 bits (184), Expect = 9e-14 Identities = 50/188 (26%), Positives = 92/188 (48%), Gaps = 10/188 (5%) Frame = +3 Query: 12 GTFGKVHFARSLESNQS---VAIKMLDKEKVL-KVGLSEQIRREVTTMRLVAHKN-IVQL 176 G +GKV R + + + A+K+L K ++ K +E R E + + +V L Sbjct: 58 GAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTL 117 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX 356 H T K++ +++Y+ GGELF +++ + TE Y +++ A+++ H G+ +R Sbjct: 118 HYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRD 177 Query: 357 XXXXXXXXXXXXXXXVSDFGLS---ALSESKRQDGLLHTTCGTPAYVAPEVI--SKTGYD 521 ++DFGLS E++R ++ CGT Y+AP+++ +G+D Sbjct: 178 IKLENILLDSNGHVVLTDFGLSKEFVADETER----AYSFCGTIEYMAPDIVRGGDSGHD 233 Query: 522 GAKSDIWS 545 A D WS Sbjct: 234 KA-VDWWS 240
>KPC1B_CAEEL (P34885) Protein kinase C-like 1B (EC 2.7.11.13) (PKC1B)| Length = 707 Score = 91.7 bits (226), Expect = 1e-18 Identities = 55/180 (30%), Positives = 90/180 (50%), Gaps = 1/180 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVA-HKNIVQLHEV 185 +G+FGKV A +++ AIK+L K+ +++ E E + L A H + LH Sbjct: 386 KGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSS 445 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T ++++FVMEYV GG+L ++ ++ K E A Y ++ A+ + H V +R Sbjct: 446 FQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYRDLKL 505 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG+ E +D L T CGTP Y+APE++ + Y G D W+ Sbjct: 506 DNILLDAEGHCRLADFGM--CKEGINKDNLTSTFCGTPDYIAPEILQEMEY-GVSVDWWA 562
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 91.7 bits (226), Expect = 1e-18 Identities = 50/179 (27%), Positives = 86/179 (48%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 EG+F V AR L +++ AIK+L+K ++K + RE M + H V+L+ Sbjct: 93 EGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTF 152 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 K+YF + Y K GEL + K G E Y +++SA++Y H +G+ HR Sbjct: 153 QDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPE 212 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG + + + ++ GT YV+PE++++ SD+W+ Sbjct: 213 NILLNEDMHIQITDFGTAKVLSPDSKQARANSFVGTAQYVSPELLTEKS-ACKSSDLWA 270
>AKT2B_XENLA (Q6IP76) RAC-beta serine/threonine-protein kinase-B (EC 2.7.11.1)| (RAC-PK-beta-B) (Protein kinase Akt-2-B) (Protein kinase B, beta-B) (PKB beta-B) Length = 485 Score = 91.7 bits (226), Expect = 1e-18 Identities = 56/178 (31%), Positives = 83/178 (46%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GTFGKV R + A+K+L KE ++ E ++ H + L Sbjct: 164 KGTFGKVILVREKATGLYYAMKILRKEVIIAKDEVAHTLTESRVLQNTKHPFLTGLKYAF 223 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 T +++ FVMEY GGELF +++ TE A Y +++SA++Y HS+ V +R Sbjct: 224 QTSDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRNVVYRDIKLE 283 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 ++DFGL E + T CGTP Y+APEV+ Y G D W Sbjct: 284 NLMLDKDGHVKITDFGL--CKEGITDGATMRTFCGTPEYLAPEVLEDNDY-GRAVDWW 338
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 91.3 bits (225), Expect = 2e-18 Identities = 56/184 (30%), Positives = 91/184 (49%), Gaps = 4/184 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G+FG+V ++ + AIK++ K+ V + + + REV ++++ H NI++L+E Sbjct: 77 KGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLDHINIMKLYEFF 136 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----X 356 N Y V + GGELFD++ + E A + +Q++S + Y H V HR Sbjct: 137 EDNNYYYLVSDVYSGGELFDEIISRKRFYEVDAARIIKQVLSGITYMHKNNVVHRDLKPE 196 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 + DFGLS E ++ + GT Y+AP+V+ T YD K D Sbjct: 197 NILLETKNKEDMIIKIIDFGLSTHFEYSKK---MKDKIGTAYYIAPDVLHGT-YD-EKCD 251 Query: 537 IWSC 548 IWSC Sbjct: 252 IWSC 255
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 91.3 bits (225), Expect = 2e-18 Identities = 56/184 (30%), Positives = 91/184 (49%), Gaps = 4/184 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G+FG+V ++ + AIK++ K+ V + + + REV ++++ H NI++L+E Sbjct: 77 KGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLDHINIMKLYEFF 136 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----X 356 N Y V + GGELFD++ + E A + +Q++S + Y H V HR Sbjct: 137 EDNNYYYLVSDVYSGGELFDEIISRKRFYEVDAARIIKQVLSGITYMHKNNVVHRDLKPE 196 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 + DFGLS E ++ + GT Y+AP+V+ T YD K D Sbjct: 197 NILLETKNKEDMIIKIIDFGLSTHFEYSKK---MKDKIGTAYYIAPDVLHGT-YD-EKCD 251 Query: 537 IWSC 548 IWSC Sbjct: 252 IWSC 255
>KKCC2_MOUSE (Q8C078) Calcium/calmodulin-dependent protein kinase kinase 2 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta) Length = 588 Score = 91.3 bits (225), Expect = 2e-18 Identities = 62/206 (30%), Positives = 100/206 (48%), Gaps = 27/206 (13%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKV-----------------------GLSEQ 119 +G++G V A + N A+K+L K+K+++ G EQ Sbjct: 173 KGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGARPAPGGCIQPRGPIEQ 232 Query: 120 IRREVTTMRLVAHKNIVQLHEVMATRNK--IYFVMEYVKGGELFDKVAKSGKLTEGAAHK 293 + +E+ ++ + H N+V+L EV+ N+ +Y V E V G + + V L+E A Sbjct: 233 VYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARF 291 Query: 294 YFQQLISAVDYCHSQGVYHRXXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCG 473 YFQ LI ++Y H Q + HR ++DFG+S +E K D LL T G Sbjct: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS--NEFKGSDALLSNTVG 349 Query: 474 TPAYVAPEVISKTG--YDGAKSDIWS 545 TPA++APE +S+T + G D+W+ Sbjct: 350 TPAFMAPESLSETRKIFSGKALDVWA 375
>KKCC2_HUMAN (Q96RR4) Calcium/calmodulin-dependent protein kinase kinase 2 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta) Length = 588 Score = 91.3 bits (225), Expect = 2e-18 Identities = 62/206 (30%), Positives = 100/206 (48%), Gaps = 27/206 (13%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKV-----------------------GLSEQ 119 +G++G V A + N A+K+L K+K+++ G EQ Sbjct: 173 KGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQ 232 Query: 120 IRREVTTMRLVAHKNIVQLHEVMATRNK--IYFVMEYVKGGELFDKVAKSGKLTEGAAHK 293 + +E+ ++ + H N+V+L EV+ N+ +Y V E V G + + V L+E A Sbjct: 233 VYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARF 291 Query: 294 YFQQLISAVDYCHSQGVYHRXXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCG 473 YFQ LI ++Y H Q + HR ++DFG+S +E K D LL T G Sbjct: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS--NEFKGSDALLSNTVG 349 Query: 474 TPAYVAPEVISKTG--YDGAKSDIWS 545 TPA++APE +S+T + G D+W+ Sbjct: 350 TPAFMAPESLSETRKIFSGKALDVWA 375
>PRKX_HUMAN (P51817) Serine/threonine-protein kinase PRKX (EC 2.7.11.1)| (Protein kinase PKX1) Length = 358 Score = 91.3 bits (225), Expect = 2e-18 Identities = 50/178 (28%), Positives = 87/178 (48%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMA 191 GTFG+VH + + A+K++ V+++ + + E + ++ V+H +++L Sbjct: 58 GTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWH 117 Query: 192 TRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXX 371 +Y +MEYV GGELF + G+ + Y ++I A++Y HS+ + +R Sbjct: 118 DERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPEN 177 Query: 372 XXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG +K+ T CGTP Y+APEVI G+ G D W+ Sbjct: 178 ILLDRDGHIKLTDFGF-----AKKLVDRTWTLCGTPEYLAPEVIQSKGH-GRAVDWWA 229
>KKCC2_RAT (O88831) Calcium/calmodulin-dependent protein kinase kinase 2 (EC| 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta) Length = 587 Score = 91.3 bits (225), Expect = 2e-18 Identities = 62/206 (30%), Positives = 100/206 (48%), Gaps = 27/206 (13%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKV-----------------------GLSEQ 119 +G++G V A + N A+K+L K+K+++ G EQ Sbjct: 172 KGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQ 231 Query: 120 IRREVTTMRLVAHKNIVQLHEVMATRNK--IYFVMEYVKGGELFDKVAKSGKLTEGAAHK 293 + +E+ ++ + H N+V+L EV+ N+ +Y V E V G + + V L+E A Sbjct: 232 VYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARF 290 Query: 294 YFQQLISAVDYCHSQGVYHRXXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCG 473 YFQ LI ++Y H Q + HR ++DFG+S +E K D LL T G Sbjct: 291 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS--NEFKGSDALLSNTVG 348 Query: 474 TPAYVAPEVISKTG--YDGAKSDIWS 545 TPA++APE +S+T + G D+W+ Sbjct: 349 TPAFMAPESLSETRKIFSGKALDVWA 374
>ULK2_HUMAN (Q8IYT8) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) Length = 1036 Score = 90.9 bits (224), Expect = 2e-18 Identities = 57/188 (30%), Positives = 91/188 (48%), Gaps = 10/188 (5%) Frame = +3 Query: 12 GTFGKVHFARSLESNQ-SVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 G F V R + VAIK ++K+ + K + + +E+ ++ + H+NIV L++V Sbjct: 18 GAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKILKELQHENIVALYDVQ 75 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----- 353 N ++ VMEY GG+L D + G L+E + Q+ +A+ HS+G+ HR Sbjct: 76 ELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQ 135 Query: 354 ----XXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYD 521 ++DFG + S + T CG+P Y+APEVI YD Sbjct: 136 NILLSYANRRKSSVSGIRIKIADFGFARYLHSNM---MAATLCGSPMYMAPEVIMSQHYD 192 Query: 522 GAKSDIWS 545 AK+D+WS Sbjct: 193 -AKADLWS 199
>CHK1_YEAST (P38147) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 527 Score = 90.9 bits (224), Expect = 2e-18 Identities = 60/187 (32%), Positives = 102/187 (54%), Gaps = 8/187 (4%) Frame = +3 Query: 9 EGTFGKVHFAR-SLESNQSVAIKMLDKEKVLKVGLSEQ-IRREVTTM-RLVAHKNIVQLH 179 +G F V A ++ + +A+K + K+GLS++ I +EV + H N+++L Sbjct: 23 QGAFACVKNAHLQMDPSIILAVKFIHVPTCKKMGLSDKDITKEVVLQSKCSKHPNVLRLI 82 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQ-GVYHRX 356 + ++ ++ ++E GG+LFDK+ + A YFQQL+SA++Y H + GV HR Sbjct: 83 DCNVSKEYMWIILEMADGGDLFDKIEPDVGVDSDVAQFYFQQLVSAINYLHVECGVAHRD 142 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTC---GTPAYVAPEVI-SKTGYDG 524 ++DFGL+ S+ +R+DG L + G+P Y+APEV+ S+ GY Sbjct: 143 IKPENILLDKNGNLKLADFGLA--SQFRRKDGTLRVSMDQRGSPPYMAPEVLYSEEGYYA 200 Query: 525 AKSDIWS 545 ++DIWS Sbjct: 201 DRTDIWS 207
>CDPK3_ORYSA (P53684) Calcium-dependent protein kinase, isoform 11 (EC 2.7.11.1)| (CDPK 11) Length = 542 Score = 90.9 bits (224), Expect = 2e-18 Identities = 58/183 (31%), Positives = 87/183 (47%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMR-LVAHKNIVQLHEV 185 +G FG + + + A K + K K++ E +RRE+ M L HKN+V + +V Sbjct: 87 QGQFGTTYLCTEINTGCEYACKTIPKRKLITKEDVEDVRREIQIMHHLSGHKNVVAIKDV 146 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX--- 356 ++ VME GGELFD++ + G +E A + + ++S V CHS GV HR Sbjct: 147 YEDGQAVHIVMELCAGGELFDRIQEKGHYSERKAAELIRIIVSIVAMCHSLGVMHRDLKP 206 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 DFGLS + + + G+P YVAPEV+ K G +SD Sbjct: 207 ENFLLLDKDDDLSIKAIDFGLSVFFKPGQ---VFTELVGSPYYVAPEVLHKR--YGPESD 261 Query: 537 IWS 545 +WS Sbjct: 262 VWS 264
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1)| (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 90.9 bits (224), Expect = 2e-18 Identities = 57/182 (31%), Positives = 95/182 (52%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSL---ESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLH 179 +G+FGKV R ++ Q A+K+L K LKV + + E + V H IV+LH Sbjct: 81 QGSFGKVFLVRKKTGPDAGQLYAMKVLKKAS-LKVRDRVRTKMERDILVEVNHPFIVKLH 139 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T K+Y ++++++GG++F +++K TE Y +L A+D+ H G+ +R Sbjct: 140 YAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDL 199 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGLS ES Q+ ++ CGT Y+APEV+++ G+ +D Sbjct: 200 KPENILLDEIGHIKLTDFGLS--KESVDQEKKAYSFCGTVEYMAPEVVNRRGH-SQSADW 256 Query: 540 WS 545 WS Sbjct: 257 WS 258 Score = 87.4 bits (215), Expect = 2e-17 Identities = 58/169 (34%), Positives = 81/169 (47%), Gaps = 4/169 (2%) Frame = +3 Query: 51 SNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVK 230 +N A+K++DK K SE+I MR H NI+ L +V +Y V + +K Sbjct: 448 TNMEFAVKIIDKSKR---DPSEEIE---ILMRYGQHPNIITLKDVFDDGRYVYLVTDLMK 501 Query: 231 GGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----XXXXXXXXXXXXXXX 398 GGEL D++ K +E A + VDY H QGV HR Sbjct: 502 GGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSI 561 Query: 399 XVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFG + + + ++GLL T C T +VAPEV+ + GYD A DIWS Sbjct: 562 RICDFGFA--KQLRGENGLLLTPCYTANFVAPEVLMQQGYDAA-CDIWS 607
>ULK2_MOUSE (Q9QY01) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2) Length = 1037 Score = 90.5 bits (223), Expect = 3e-18 Identities = 57/188 (30%), Positives = 92/188 (48%), Gaps = 10/188 (5%) Frame = +3 Query: 12 GTFGKVHFARSLESNQ-SVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 G F V R + VAIK ++K+ + K + + +E+ ++ + H+NIV L++V Sbjct: 18 GAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKILKELQHENIVALYDVQ 75 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----- 353 N ++ VMEY GG+L D + G L+E + Q+ +A+ HS+G+ HR Sbjct: 76 ELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQ 135 Query: 354 ----XXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYD 521 ++DFG + S + + T CG+P Y+APEVI YD Sbjct: 136 NILLSYANRRKSNVSGIRIKIADFGFARYLHS---NTMAATLCGSPMYMAPEVIMSQHYD 192 Query: 522 GAKSDIWS 545 AK+D+WS Sbjct: 193 -AKADLWS 199
>CHK2_CAEEL (Q9U1Y5) Serine/threonine-protein kinase chk-2 (EC 2.7.11.1)| (Ce-cds-1) (Ce-chk-2) Length = 476 Score = 90.5 bits (223), Expect = 3e-18 Identities = 64/191 (33%), Positives = 92/191 (48%), Gaps = 12/191 (6%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLK----VGLSEQIRREVTTMRLVAHKNIVQL 176 +G FGKV VAIK L+ + + + + IR EV M+ ++H NIV + Sbjct: 178 KGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRDIRNEVEVMKKLSHPNIVAI 237 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAH---KYFQ-QLISAVDYCHSQGV 344 ++ + Y V+EYV GGE F KV S G KYF QLI A+ Y HS G+ Sbjct: 238 YDWITVAKYSYMVIEYVGGGEFFSKVVDSKYNRMGLGESLGKYFAFQLIDAILYLHSVGI 297 Query: 345 YHRXXXXXXXXXXXXXXXXV---SDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTG 515 HR + +DFG++ S ++ + T CGTP+Y APE+++ G Sbjct: 298 CHRDIKPENILCSDKAERCILKLTDFGMAKNSVNR-----MKTRCGTPSYNAPEIVANEG 352 Query: 516 YD-GAKSDIWS 545 + K DIWS Sbjct: 353 VEYTPKVDIWS 363
>KAPC_ENCCU (Q8SRK8) Probable cAMP-dependent protein kinase catalytic subunit| (EC 2.7.11.11) Length = 322 Score = 90.5 bits (223), Expect = 3e-18 Identities = 57/179 (31%), Positives = 90/179 (50%), Gaps = 2/179 (1%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSV-AIKMLDKEKVLKVGLSEQIRREVTTM-RLVAHKNIVQLHEV 185 G FGKVH R S SV A+KMLD ++L+ L++Q+ E++ + R+ + +L+ Sbjct: 16 GAFGKVHLVRLKSSPTSVFAMKMLDFGEILRQRLADQLENEISILKRIYGCPFVAKLYST 75 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 K+ +MEYV GGELF + K G+ E A Y ++ISA+ + H +G+ +R Sbjct: 76 DFHGGKVGLIMEYVGGGELFYWLKKCGRFDEQMARFYAAEIISALRFIHGRGILYRDLKP 135 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIW 542 + DFG S ++ GTP Y++PE + ++ DG SD W Sbjct: 136 ENILITSTGHIKLIDFGFSVYESEN-----IYMISGTPEYMSPEKL-RSEDDGRASDYW 188
>SSP1_SCHPO (P50526) Serine/threonine-protein kinase ssp1 (EC 2.7.11.1)| Length = 652 Score = 90.5 bits (223), Expect = 3e-18 Identities = 56/175 (32%), Positives = 93/175 (53%), Gaps = 12/175 (6%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDK-EKVLKVGLS------EQIRREVTTMRLVAHKNIV 170 G GKV R + + +AIK++ K E+ K+G + E++RRE+ ++ H N+V Sbjct: 144 GMHGKVKLGRDTVTRELLAIKIIPKTERRPKLGRANASSQKEKVRREIAILKKCVHPNVV 203 Query: 171 QLHEVM--ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGV 344 +L EV+ + K+Y V+EY+ GGE+ S L+ A +YF+ ++ ++Y H QG+ Sbjct: 204 RLREVIDDPSSTKVYLVLEYMSGGEVPWTDCDSPVLSISEARQYFRDVVLGLEYLHYQGI 263 Query: 345 YHRXXXXXXXXXXXXXXXXVSDFGLSALSE---SKRQDGLLHTTCGTPAYVAPEV 500 HR +SDFG+S ++ ++ D L T GTPA+ APE+ Sbjct: 264 IHRDIKPANLLLNSSNCVKISDFGVSYIANAGLNEDNDVELAKTVGTPAFFAPEL 318
>KCC2A_RAT (P11275) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 90.5 bits (223), Expect = 3e-18 Identities = 56/183 (30%), Positives = 89/183 (48%), Gaps = 3/183 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V + + Q A K+++ +K L +++ RE RL+ H NIV+LH+ + Sbjct: 21 KGAFSVVRRCVKVLAGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPNIVRLHDSI 79 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---X 359 + Y + + V GGELF+ + +E A QQ++ AV +CH GV HR Sbjct: 80 SEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPE 139 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGL+ E ++Q GTP Y++PEV+ K Y G D+ Sbjct: 140 NLLLASKLKGAAVKLADFGLAIEVEGEQQ--AWFGFAGTPGYLSPEVLRKDPY-GKPVDL 196 Query: 540 WSC 548 W+C Sbjct: 197 WAC 199
>KCC2A_PONPY (Q5RCC4) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 90.5 bits (223), Expect = 3e-18 Identities = 56/183 (30%), Positives = 89/183 (48%), Gaps = 3/183 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V + + Q A K+++ +K L +++ RE RL+ H NIV+LH+ + Sbjct: 21 KGAFSVVRRCVKVLAGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPNIVRLHDSI 79 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---X 359 + Y + + V GGELF+ + +E A QQ++ AV +CH GV HR Sbjct: 80 SEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPE 139 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGL+ E ++Q GTP Y++PEV+ K Y G D+ Sbjct: 140 NLLLASKLKGAAVKLADFGLAIEVEGEQQ--AWFGFAGTPGYLSPEVLRKDPY-GKPVDL 196 Query: 540 WSC 548 W+C Sbjct: 197 WAC 199
>KCC2A_HUMAN (Q9UQM7) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 90.5 bits (223), Expect = 3e-18 Identities = 56/183 (30%), Positives = 89/183 (48%), Gaps = 3/183 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V + + Q A K+++ +K L +++ RE RL+ H NIV+LH+ + Sbjct: 21 KGAFSVVRRCVKVLAGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPNIVRLHDSI 79 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---X 359 + Y + + V GGELF+ + +E A QQ++ AV +CH GV HR Sbjct: 80 SEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPE 139 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGL+ E ++Q GTP Y++PEV+ K Y G D+ Sbjct: 140 NLLLASKLKGAAVKLADFGLAIEVEGEQQ--AWFGFAGTPGYLSPEVLRKDPY-GKPVDL 196 Query: 540 WSC 548 W+C Sbjct: 197 WAC 199
>KPC3_DROME (P13678) Protein kinase C (EC 2.7.11.13) (PKC) (dPKC98F)| Length = 634 Score = 90.5 bits (223), Expect = 3e-18 Identities = 55/184 (29%), Positives = 97/184 (52%), Gaps = 5/184 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVA----HKNIVQL 176 +G+FGKV A +++ AIK+L K+ +++ + + +T R++A H + L Sbjct: 311 KGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQ---DDDVDCTMTEKRILALAANHPFLTAL 367 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX 356 H T ++++FVMEYV GG+L ++ K+ + A Y ++ A+ + H+ GV +R Sbjct: 368 HSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRD 427 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTT-CGTPAYVAPEVISKTGYDGAKS 533 ++DFG + + +G+L TT CGTP Y+APE++ + Y GA Sbjct: 428 LKLDNILLDQEGHCKLADFG---MCKEGIMNGMLTTTFCGTPDYIAPEILKEQEY-GASV 483 Query: 534 DIWS 545 D W+ Sbjct: 484 DWWA 487
>CDPK3_PLAYO (Q7RAV5) Calcium-dependent protein kinase 3 (EC 2.7.11.1)| Length = 538 Score = 90.5 bits (223), Expect = 3e-18 Identities = 57/182 (31%), Positives = 90/182 (49%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GT+G V+ A A+K++ K+K+ + + R+E+ M+ + H N+++L E Sbjct: 120 KGTYGCVYKATDKLLKIQRAVKVVSKKKLKNI---PRFRQEIDIMKNLDHPNVIKLLETF 176 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---X 359 +IY +M+ GGELFDK+ K G E A +Q+ S ++Y H + + HR Sbjct: 177 EDEEQIYLIMDLCTGGELFDKIIKKGSFVEMYASFIMKQIFSVLNYLHIRNICHRDIKPE 236 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 + DFGL+A D + T GTP YVAP+V+ TG K D+ Sbjct: 237 NFLFYDKSTESLIKIIDFGLAAYFND--IDYEMKTKAGTPYYVAPQVL--TGCYDYKCDL 292 Query: 540 WS 545 WS Sbjct: 293 WS 294
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 90.1 bits (222), Expect = 4e-18 Identities = 57/188 (30%), Positives = 90/188 (47%), Gaps = 10/188 (5%) Frame = +3 Query: 12 GTFGKVHFARSLESNQ-SVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 G F V R E + VA+K ++K+ + K + +E+ ++ + H+NIV L++ Sbjct: 25 GAFAVVFKGRHREKHDLEVAVKCINKKNLAKS--QTLLGKEIKILKELKHENIVALYDFQ 82 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----- 353 N +Y VMEY GG+L D + L+E + QQ+ A+ HS+G+ HR Sbjct: 83 EMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQ 142 Query: 354 ----XXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYD 521 ++DFG + +S + T CG+P Y+APEVI YD Sbjct: 143 NILLSNPAGRRANPNSIRVKIADFGFARYLQSNM---MAATLCGSPMYMAPEVIMSQHYD 199 Query: 522 GAKSDIWS 545 G K+D+WS Sbjct: 200 G-KADLWS 206
>KS6A4_MOUSE (Q9Z2B9) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK) Length = 773 Score = 90.1 bits (222), Expect = 4e-18 Identities = 58/184 (31%), Positives = 90/184 (48%), Gaps = 5/184 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLV-AHKNIVQLHEV 185 +G+F R +S Q A+K+L + L E +REV +RL +H N+V LHEV Sbjct: 419 QGSFSVCRRCRQRQSGQEFAVKILSRR------LEENTQREVAALRLCQSHPNVVNLHEV 472 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQ-GVYHRX-- 356 + + Y V+E ++GGEL + + K +E A + + L+SAV + H + GV HR Sbjct: 473 LHDQLHTYLVLELLRGGELLEHIRKKRLFSESEASQILRSLVSAVSFMHEEAGVVHRDLK 532 Query: 357 -XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKS 533 + DFG + L + + T C T Y APE++++ GYD Sbjct: 533 PENILYADDTPGAPVKIIDFGFARLRPQSPAEP-MQTPCFTLQYAAPELLAQQGYD-ESC 590 Query: 534 DIWS 545 D+WS Sbjct: 591 DLWS 594 Score = 73.9 bits (180), Expect = 3e-13 Identities = 51/185 (27%), Positives = 86/185 (46%), Gaps = 7/185 (3%) Frame = +3 Query: 12 GTFGKVHFARSL---ESNQSVAIKMLDKEKVL-KVGLSEQIRREVTTMRLVAHKN-IVQL 176 G +GKV R ++ + A+K+L K ++ + E R E + + LV +V L Sbjct: 42 GAYGKVFLVRKTGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTL 101 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX 356 H T K++ +++YV GGE+F + + E Y +++ A+++ H G+ +R Sbjct: 102 HYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRD 161 Query: 357 XXXXXXXXXXXXXXXVSDFGLSA--LSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAK 530 ++DFGLS L+E K + + CGT Y+APE+I G Sbjct: 162 LKLENVLLDSEGHIVLTDFGLSKEFLTEEKER---TFSFCGTIEYMAPEIIRSKAGHGKA 218 Query: 531 SDIWS 545 D WS Sbjct: 219 VDWWS 223
>KPC1_LYTPI (Q25378) Protein kinase C (EC 2.7.11.13)| Length = 658 Score = 90.1 bits (222), Expect = 4e-18 Identities = 54/183 (29%), Positives = 92/183 (50%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKN----IVQL 176 +G+FGKV A +++ AIK+L K+ +++ + + +T R++ + + L Sbjct: 333 KGSFGKVMLAEKKGTDELYAIKILKKDVIIQ---DDDVECTMTEKRVLGLPSKPAFLTAL 389 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX 356 H T ++++FVME+V GG+L ++ K GK E A Y ++ + Y HSQGV +R Sbjct: 390 HSCFQTMDRLFFVMEFVNGGDLMFQIQKVGKFREPHAVFYAAEIAVGLFYLHSQGVIYRD 449 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 ++DFG+ E + T CGTP Y+APE+++ Y G D Sbjct: 450 LKLDNVLVDAEGHIKIADFGM--CKEHMNEGDTTRTFCGTPDYIAPEIVAYQPY-GKAVD 506 Query: 537 IWS 545 W+ Sbjct: 507 WWA 509
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 90.1 bits (222), Expect = 4e-18 Identities = 55/182 (30%), Positives = 96/182 (52%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSL---ESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLH 179 +G+FGKV R + +S A+K+L K+ LKV + + E + V H +V+LH Sbjct: 70 QGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILADVNHPFVVKLH 128 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T K+Y ++++++GG+LF +++K TE Y +L +D+ HS G+ +R Sbjct: 129 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 188 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGLS E+ + ++ CGT Y+APEV+++ G+ + +D Sbjct: 189 KPENILLDEEGHIKLTDFGLS--KEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHS-ADW 245 Query: 540 WS 545 WS Sbjct: 246 WS 247 Score = 83.2 bits (204), Expect = 4e-16 Identities = 56/169 (33%), Positives = 81/169 (47%), Gaps = 4/169 (2%) Frame = +3 Query: 51 SNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVK 230 +N A+K++DK K SE+I +R H NI+ L +V +Y V E ++ Sbjct: 440 TNMEYAVKVIDKSKR---DPSEEIE---ILLRYGQHPNIITLKDVYDDGKHVYLVTELMR 493 Query: 231 GGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXXXXXXXXXX----X 398 GGEL DK+ + +E A + V+Y HSQGV HR Sbjct: 494 GGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECL 553 Query: 399 XVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFG + + + ++GLL T C T +VAPEV+ + GYD DIWS Sbjct: 554 RICDFGFA--KQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG-CDIWS 599
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 90.1 bits (222), Expect = 4e-18 Identities = 57/188 (30%), Positives = 90/188 (47%), Gaps = 10/188 (5%) Frame = +3 Query: 12 GTFGKVHFARSLESNQ-SVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 G F V R E + VA+K ++K+ + K + +E+ ++ + H+NIV L++ Sbjct: 25 GAFAVVFKGRHREKHDLEVAVKCINKKNLAKS--QTLLGKEIKILKELKHENIVALYDFQ 82 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR----- 353 N +Y VMEY GG+L D + L+E + QQ+ A+ HS+G+ HR Sbjct: 83 EMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQ 142 Query: 354 ----XXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYD 521 ++DFG + +S + T CG+P Y+APEVI YD Sbjct: 143 NILLSNPGGRRANPSNIRVKIADFGFARYLQSNM---MAATLCGSPMYMAPEVIMSQHYD 199 Query: 522 GAKSDIWS 545 G K+D+WS Sbjct: 200 G-KADLWS 206
>SGK3_MOUSE (Q9ERE3) Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) (Cytokine independent survival kinase) Length = 496 Score = 89.7 bits (221), Expect = 5e-18 Identities = 60/181 (33%), Positives = 85/181 (46%), Gaps = 1/181 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTM-RLVAHKNIVQLHEV 185 +G+FGKV A+ + A+K+L K+ VL + I E + + V H +V LH Sbjct: 170 KGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYS 229 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T K+YFV+++V GGELF + + E A Y ++ SA+ Y HS + +R Sbjct: 230 FQTTEKLYFVLDFVNGGELFFHLQRERSFPEPRARFYAAEIASALGYLHSIKIVYRDLKP 289 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL E T CGTP Y+APEVI K YD W Sbjct: 290 ENILLDSMGHVVLTDFGL--CKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVD--WW 345 Query: 546 C 548 C Sbjct: 346 C 346
>SGK3_HUMAN (Q96BR1) Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) Length = 496 Score = 89.7 bits (221), Expect = 5e-18 Identities = 60/181 (33%), Positives = 85/181 (46%), Gaps = 1/181 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTM-RLVAHKNIVQLHEV 185 +G+FGKV A+ + A+K+L K+ VL + I E + + V H +V LH Sbjct: 170 KGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYS 229 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXX 365 T K+YFV+++V GGELF + + E A Y ++ SA+ Y HS + +R Sbjct: 230 FQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKP 289 Query: 366 XXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFGL E T CGTP Y+APEVI K YD W Sbjct: 290 ENILLDSVGHVVLTDFGL--CKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVD--WW 345 Query: 546 C 548 C Sbjct: 346 C 346
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 89.7 bits (221), Expect = 5e-18 Identities = 60/182 (32%), Positives = 88/182 (48%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GT+G V+ +NQ AIK K+++ + + +E+ M+ + H NIV+L+E Sbjct: 79 QGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNIN---RFFQEIEIMKKLDHPNIVKLYETY 135 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---X 359 N IY +ME G ELFD + ++G TE A +Q+ SA+ Y HS + HR Sbjct: 136 ENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPE 195 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 + DFG LS++ T GTP YVAP+V+ G K DI Sbjct: 196 NFLFQSENKDSLLKIIDFG---LSKNLGTGEFTTTKAGTPYYVAPQVLD--GKYDKKCDI 250 Query: 540 WS 545 WS Sbjct: 251 WS 252
>KCC2D_RAT (P15791) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 533 Score = 89.7 bits (221), Expect = 5e-18 Identities = 54/183 (29%), Positives = 89/183 (48%), Gaps = 3/183 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V + + Q A K+++ +K L +++ RE RL+ H NIV+LH+ + Sbjct: 22 KGAFSVVRRCMKIPTGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPNIVRLHDSI 80 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---X 359 + Y V + V GGELF+ + +E A QQ++ +V++CH G+ HR Sbjct: 81 SEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPE 140 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGL+ + +Q GTP Y++PEV+ K Y G D+ Sbjct: 141 NLLLASKSKGAAVKLADFGLAIEVQGDQQ--AWFGFAGTPGYLSPEVLRKDPY-GKPVDM 197 Query: 540 WSC 548 W+C Sbjct: 198 WAC 200
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 89.7 bits (221), Expect = 5e-18 Identities = 55/182 (30%), Positives = 96/182 (52%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSL---ESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLH 179 +G+FGKV R + +S A+K+L K+ LKV + + E + V H +V+LH Sbjct: 70 QGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILADVNHPFVVKLH 128 Query: 180 EVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXX 359 T K+Y ++++++GG+LF +++K TE Y +L +D+ HS G+ +R Sbjct: 129 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 188 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGLS E+ + ++ CGT Y+APEV+++ G+ + +D Sbjct: 189 KPENILLDEEGHIKLTDFGLS--KEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTHS-ADW 245 Query: 540 WS 545 WS Sbjct: 246 WS 247 Score = 84.0 bits (206), Expect = 3e-16 Identities = 56/169 (33%), Positives = 81/169 (47%), Gaps = 4/169 (2%) Frame = +3 Query: 51 SNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVMATRNKIYFVMEYVK 230 +N A+K++DK K SE+I +R H NI+ L +V +Y V E ++ Sbjct: 429 TNMEYAVKVIDKSKR---DPSEEIE---ILLRYGQHPNIITLKDVYDDGKHVYLVTELMR 482 Query: 231 GGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXXXXXXXXXXX----X 398 GGEL DK+ + +E A + V+Y HSQGV HR Sbjct: 483 GGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECL 542 Query: 399 XVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDIWS 545 + DFG + + + ++GLL T C T +VAPEV+ + GYD DIWS Sbjct: 543 RICDFGFA--KQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG-CDIWS 588
>KCC2D_HUMAN (Q13557) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 499 Score = 89.7 bits (221), Expect = 5e-18 Identities = 54/183 (29%), Positives = 89/183 (48%), Gaps = 3/183 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G F V + + Q A K+++ +K L +++ RE RL+ H NIV+LH+ + Sbjct: 22 KGAFSVVRRCMKIPTGQGYAAKIINTKK-LSARDHQKLEREARICRLLKHPNIVRLHDSI 80 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---X 359 + Y V + V GGELF+ + +E A QQ++ +V++CH G+ HR Sbjct: 81 SEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPE 140 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 ++DFGL+ + +Q GTP Y++PEV+ K Y G D+ Sbjct: 141 NLLLASKSKGAAVKLADFGLAIEVQGDQQ--AWFGFAGTPGYLSPEVLRKDPY-GKPVDM 197 Query: 540 WSC 548 W+C Sbjct: 198 WAC 200
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 89.7 bits (221), Expect = 5e-18 Identities = 60/182 (32%), Positives = 88/182 (48%), Gaps = 3/182 (1%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +GT+G V+ +NQ AIK K+++ + + +E+ M+ + H NIV+L+E Sbjct: 79 QGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNIN---RFFQEIEIMKKLDHPNIVKLYETY 135 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX---X 359 N IY +ME G ELFD + ++G TE A +Q+ SA+ Y HS + HR Sbjct: 136 ENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPE 195 Query: 360 XXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSDI 539 + DFG LS++ T GTP YVAP+V+ G K DI Sbjct: 196 NFLFQSENKDSLLKIIDFG---LSKNLGTGEFTTTKAGTPYYVAPQVLD--GKYDKKCDI 250 Query: 540 WS 545 WS Sbjct: 251 WS 252
>PASK_MOUSE (Q8CEE6) PAS domain-containing serine/threonine-protein kinase (EC| 2.7.11.1) (PAS-kinase) (PASKIN) Length = 1383 Score = 89.4 bits (220), Expect = 6e-18 Identities = 61/184 (33%), Positives = 89/184 (48%), Gaps = 6/184 (3%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSE-----QIRREVTTMRLVAHKNIVQL 176 G FG V A E N+ V +K + KEKVL+ E ++ E+ + V H NI+++ Sbjct: 1068 GAFGFVWTAVEKECNKEVVVKFIKKEKVLEDCWIEDPKLGRVTLEIAILSKVDHANIIKV 1127 Query: 177 HEVMATRNKIYFVME-YVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHR 353 ++ + VME + G +LF + L E A F+QL+SAV Y HSQG+ HR Sbjct: 1128 LDIFENQEFFQLVMEKHGSGMDLFAFIDHHPCLDEPLASFIFRQLVSAVGYLHSQGIIHR 1187 Query: 354 XXXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKS 533 + DFG +A E + L +T CGT Y APEV+ Y G + Sbjct: 1188 DIKDENIVIAEDFTIKLIDFGSAAYLERGK---LFYTFCGTIEYCAPEVLIGNPYRGPEL 1244 Query: 534 DIWS 545 ++WS Sbjct: 1245 EMWS 1248
>KPCL_HUMAN (P24723) Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta)| (PKC-L) Length = 682 Score = 89.4 bits (220), Expect = 6e-18 Identities = 56/183 (30%), Positives = 93/183 (50%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVA----HKNIVQL 176 +G+FGKV AR E+ A+K+L K+ +L L + + +T R+++ H + QL Sbjct: 362 KGSFGKVMLARVKETGDLYAVKVLKKDVIL---LDDDVECTMTEKRILSLARNHPFLTQL 418 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX 356 T ++++FVME+V GG+L + KS + E A Y ++ISA+ + H +G+ +R Sbjct: 419 FCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRD 478 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 ++DFG+ E T CGTP Y+APE++ + Y G D Sbjct: 479 LKLDNVLLDHEGHCKLADFGM--CKEGICNGVTTATFCGTPDYIAPEILQEMLY-GPAVD 535 Query: 537 IWS 545 W+ Sbjct: 536 WWA 538
>KS6A5_PONPY (Q5R4K3) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 802 Score = 89.4 bits (220), Expect = 6e-18 Identities = 58/183 (31%), Positives = 89/183 (48%), Gaps = 4/183 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLV-AHKNIVQLHEV 185 EG+F +SNQ+ A+K++ K + ++E+T ++L H NIV+LHEV Sbjct: 434 EGSFSICRKCVHKKSNQAFAVKIISKR------MEANTQKEITALKLCEGHPNIVKLHEV 487 Query: 186 MATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX--- 356 + + VME + GGELF+++ K +E A ++L+SAV + H GV HR Sbjct: 488 FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 547 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGAKSD 536 + DFG + Q L T C T Y APE++++ GYD D Sbjct: 548 ENLLFTDENDNLEIKIIDFGFARPKPPDNQP--LKTPCFTLHYAAPELLNQNGYD-ESCD 604 Query: 537 IWS 545 +WS Sbjct: 605 LWS 607 Score = 74.3 bits (181), Expect = 2e-13 Identities = 49/190 (25%), Positives = 94/190 (49%), Gaps = 12/190 (6%) Frame = +3 Query: 12 GTFGKVHFARSLESNQS---VAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKN----IV 170 G +GKV R + + + A+K+L K +++ + + R T +++ H +V Sbjct: 58 GAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTR--TERQVLEHTRQSPFLV 115 Query: 171 QLHEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYH 350 LH T K++ +++Y+ GGELF +++ + TE Y +++ A+++ H G+ + Sbjct: 116 TLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIY 175 Query: 351 RXXXXXXXXXXXXXXXXVSDFGLS---ALSESKRQDGLLHTTCGTPAYVAPEVI--SKTG 515 R ++DFGLS E++R ++ CGT Y+AP+++ +G Sbjct: 176 RDIKLENILLDSNGHVMLTDFGLSKEFVADETER----AYSFCGTIEYMAPDIVRGGDSG 231 Query: 516 YDGAKSDIWS 545 +D A D WS Sbjct: 232 HDKA-VDWWS 240
>KPCE_RAT (P09216) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 89.0 bits (219), Expect = 8e-18 Identities = 55/188 (29%), Positives = 98/188 (52%), Gaps = 9/188 (4%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVA----HKNIVQL 176 +G+FGKV A ++ A+K+L K+ +L+ + + +T R++A H + QL Sbjct: 416 KGSFGKVMLAELKGKDEVYAVKVLKKDVILQ---DDDVDCTMTEKRILALARKHPYLTQL 472 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX 356 + T+++++FVMEYV GG+L ++ +S K E + Y ++ SA+ + H GV +R Sbjct: 473 YCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSGFYAAEVTSALMFLHQHGVIYRD 532 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLH-----TTCGTPAYVAPEVISKTGYD 521 ++DFG+ ++G+L+ T CGTP Y+APE++ + Y Sbjct: 533 LKLDNILLDAEGHSKLADFGMC-------KEGILNGVTTTTFCGTPDYIAPEILQELEY- 584 Query: 522 GAKSDIWS 545 G D W+ Sbjct: 585 GPSVDWWA 592
>KPCE_MOUSE (P16054) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 89.0 bits (219), Expect = 8e-18 Identities = 55/184 (29%), Positives = 97/184 (52%), Gaps = 5/184 (2%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVA----HKNIVQL 176 +G+FGKV A ++ A+K+L K+ +L+ + + +T R++A H + QL Sbjct: 416 KGSFGKVMLAELKGKDEVYAVKVLKKDVILQ---DDDVDCTMTEKRILALARKHPYLTQL 472 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX 356 + T+++++FVMEYV GG+L ++ +S K E + Y ++ SA+ + H GV +R Sbjct: 473 YCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRD 532 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTT-CGTPAYVAPEVISKTGYDGAKS 533 ++DFG + + +G+ TT CGTP Y+APE++ + Y G Sbjct: 533 LKLDNILLDAEGHCKLADFG---MCKEGIMNGVTTTTFCGTPDYIAPEILQELEY-GPSV 588 Query: 534 DIWS 545 D W+ Sbjct: 589 DWWA 592
>KPCE_HUMAN (Q02156) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 89.0 bits (219), Expect = 8e-18 Identities = 55/188 (29%), Positives = 98/188 (52%), Gaps = 9/188 (4%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVA----HKNIVQL 176 +G+FGKV A ++ A+K+L K+ +L+ + + +T R++A H + QL Sbjct: 416 KGSFGKVMLAELKGKDEVYAVKVLKKDVILQ---DDDVDCTMTEKRILALARKHPYLTQL 472 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX 356 + T+++++FVMEYV GG+L ++ +S K E + Y ++ SA+ + H GV +R Sbjct: 473 YCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRD 532 Query: 357 XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLH-----TTCGTPAYVAPEVISKTGYD 521 ++DFG+ ++G+L+ T CGTP Y+APE++ + Y Sbjct: 533 LKLDNILLDAEGHCKLADFGMC-------KEGILNGVTTTTFCGTPDYIAPEILQELEY- 584 Query: 522 GAKSDIWS 545 G D W+ Sbjct: 585 GPSVDWWA 592
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 89.0 bits (219), Expect = 8e-18 Identities = 62/180 (34%), Positives = 91/180 (50%), Gaps = 1/180 (0%) Frame = +3 Query: 9 EGTFGKVHFARSLESNQSVAIKMLDKEKVLKVGLSEQIRREVTTMRLVAHKNIVQLHEVM 188 +G G V+ A + +N SVAIK ++ EK K E I E+ M+ H NIV + Sbjct: 628 QGASGGVYTAYEIGTNVSVAIKQMNLEKQPK---KELIINEILVMKGSKHPNIVNFIDSY 684 Query: 189 ATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRXXXXX 368 + ++ +MEY++GG L D V LTEG ++ +S +++ HS+GV HR Sbjct: 685 VLKGDLWVIMEYMEGGSLTDVVTHC-ILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSD 743 Query: 369 XXXXXXXXXXXVSDFGLSALSESKRQDGLLHTT-CGTPAYVAPEVISKTGYDGAKSDIWS 545 ++DFG A + L TT GTP ++APEV+S+ Y G K DIWS Sbjct: 744 NILLSMEGDIKLTDFGFCA---QINELNLKRTTMVGTPYWMAPEVVSRKEY-GPKVDIWS 799
>CHK2_MOUSE (Q9Z265) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1)| Length = 546 Score = 89.0 bits (219), Expect = 8e-18 Identities = 56/188 (29%), Positives = 90/188 (47%), Gaps = 10/188 (5%) Frame = +3 Query: 12 GTFGKVHFARSLESNQSVAIKMLDKEKVL-----KVGLSEQIRREVTTMRLVAHKNIVQL 176 G G+V A ++ Q VAIK++ K + + + + E+ ++ + H I+++ Sbjct: 233 GACGEVKMAFERKTCQKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCIIKI 292 Query: 177 HEVMATRNKIYFVMEYVKGGELFDKVAKSGKLTEGAAHKYFQQLISAVDYCHSQGVYHRX 356 +V + Y V+E ++GGELFD+V + +L E YF Q++ AV Y H G+ HR Sbjct: 293 KDVFDAED-YYIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLVAVQYLHENGIIHRD 351 Query: 357 ---XXXXXXXXXXXXXXXVSDFGLSALSESKRQDGLLHTTCGTPAYVAPEVISKTGYDGA 527 ++DFG S + + L+ T CGTP Y+APEV+ G G Sbjct: 352 LKPENVLLSSQEEDCLIKITDFGQSKI---LGETSLMRTLCGTPTYLAPEVLVSNGTAGY 408 Query: 528 KS--DIWS 545 D WS Sbjct: 409 SRAVDCWS 416 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 86,496,168 Number of Sequences: 219361 Number of extensions: 1822799 Number of successful extensions: 8122 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6292 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6647 length of database: 80,573,946 effective HSP length: 105 effective length of database: 57,541,041 effective search space used: 4430660157 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
