Clone Information

BLAST Search Result

Clone Name	rbasdo06
Clone Library Name	barley_pub

No.	Definition	Score (bits)	E Value
1	HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3	111	2e-24
2	HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing...	105	1e-22
3	HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing...	104	3e-22
4	HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing...	103	4e-22
5	HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing...	103	5e-22
6	RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (R...	97	7e-20
7	RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Reg...	96	9e-20
8	RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (R...	95	2e-19
9	RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (R...	95	2e-19
10	RCC2_BRARE (Q6NYE2) Protein RCC2 homolog	93	1e-18
11	RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 k...	93	1e-18
12	RCC2_XENLA (Q52KW8) Protein RCC2 homolog	91	5e-18
13	RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator	89	1e-17
14	NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7...	89	1e-17
15	RCC2_MOUSE (Q8BK67) Protein RCC2	89	2e-17
16	RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (R...	88	3e-17
17	GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related ...	87	5e-17
18	NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7...	84	3e-16
19	RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator	82	1e-15
20	RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulat...	81	4e-15
21	RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (R...	79	1e-14
22	RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regula...	77	7e-14
23	ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein...	76	9e-14
24	RCC1_CANAL (P52499) Protein RCC1	76	9e-14
25	ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)	76	1e-13
26	NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7...	74	5e-13
27	NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7...	74	6e-13
28	GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related ...	73	8e-13
29	RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)	73	1e-12
30	NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7...	72	2e-12
31	ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein...	72	2e-12
32	NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7...	71	3e-12
33	RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromo...	71	4e-12
34	RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromo...	70	5e-12
35	RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromo...	70	7e-12
36	RCC1_XENLA (P25183) Regulator of chromosome condensation	70	7e-12
37	HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-...	67	7e-11
38	RCC1_DROME (P25171) Regulator of chromosome condensation (Chroma...	66	1e-10
39	RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 ...	65	3e-10
40	WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region ...	64	4e-10
41	WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region ...	64	5e-10
42	MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (E...	62	2e-09
43	RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-) ...	60	5e-09
44	MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (E...	58	3e-08
45	ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)	47	5e-05
46	RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell c...	43	0.001
47	FBX24_HUMAN (O75426) F-box only protein 24	39	0.013
48	FBX24_MOUSE (Q9D417) F-box only protein 24	38	0.037
49	CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 pr...	36	0.14
50	YB9W_YEAST (P38352) F-box protein YBR280C	35	0.18
51	POF9_SCHPO (O74381) F-box protein pof9	35	0.31
52	UNC5B_HUMAN (Q8IZJ1) Netrin receptor UNC5B precursor (Unc-5 homo...	34	0.53
53	TKT_SCHPO (Q9URM2) Probable transketolase (EC 2.2.1.1) (TK)	32	1.5
54	NAH_SCHPO (P36606) Na(+)/H(+) antiporter	32	2.0
55	TIP_RAT (Q8R4E1) T-cell immunomodulatory protein precursor (Prot...	31	4.5

>HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3|
          Length = 1050

 Score =  111 bits (278), Expect = 2e-24
 Identities = 70/200 (35%), Positives = 103/200 (51%), Gaps = 4/200 (2%)
 Frame = -2

Query: 718 NISTPVRVQGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQP-RSQPIR 548
           +++ P  +Q L Q +++ V  G +H LAL+ D   + WG N +GQLG+G   P ++ P R
Sbjct: 124 SVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQR 183

Query: 547 VEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGE 368
           V  L  + L  +AAGG HS AL+  G V+ WG    G+LG  D+K     P  V+LL  +
Sbjct: 184 VRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES-PCHVKLLRTQ 242

Query: 367 DIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHP-MEVPINLPPPKTSTSS 191
            +V +SCG  H+ VLT  G +F++                GH  M   +N   P+     
Sbjct: 243 KVVYISCGEEHTAVLTKSGGVFTFGAGSCGQL--------GHDSMNDEVN---PRRVLEL 291

Query: 190 EGLWQANYVACGGRHTLAIV 131
            G  +   +ACG +HTLA V
Sbjct: 292 MGS-EVTQIACGRQHTLAFV 310



 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 53/185 (28%), Positives = 88/185 (47%), Gaps = 1/185 (0%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR-SQPIRVEGLSNLSLVDIA 509
           + +  +A G  H+LALS    L++WG    GQLG+  T+   + P  ++ L+  +++ ++
Sbjct: 84  QHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVS 143

Query: 508 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
            G WH  AL  +G+ + WG+  HG+LG G +  S   P +V+ L G  + QV+ GG HS 
Sbjct: 144 CGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSF 203

Query: 328 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGR 149
            L+  G +F +            +     P  V + L   K            Y++CG  
Sbjct: 204 ALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKL-LRTQKVV----------YISCGEE 252

Query: 148 HTLAI 134
           HT  +
Sbjct: 253 HTAVL 257



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 58/184 (31%), Positives = 95/184 (51%), Gaps = 3/184 (1%)
 Frame = -2

Query: 712 STPVRVQGLEQVSM--IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG 539
           ++P RV+ LE + +  +A G  H+ ALS+   ++ WG N  GQLG+ D + R  P  V+ 
Sbjct: 179 ASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKL 238

Query: 538 LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV 359
           L    +V I+ G  H+A LTK G V+ +G G  G+LG  D  +  + P +V  L G ++ 
Sbjct: 239 LRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH-DSMNDEVNPRRVLELMGSEVT 297

Query: 358 QVSCGGTHSVV-LTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGL 182
           Q++CG  H++  + S G I+++            ++ TGH   V       K  +  +G 
Sbjct: 298 QIACGRQHTLAFVPSSGLIYAF------GCGARGQLGTGHTCNV-------KCPSPVKGY 344

Query: 181 WQAN 170
           W A+
Sbjct: 345 WAAH 348



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 57/182 (31%), Positives = 91/182 (50%)
 Frame = -2

Query: 679 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 500
           V  +A G  H++ L  D  ++  G N  GQLG    +  ++P ++  L++  ++ +A G 
Sbjct: 36  VKEVACGGNHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGALADQHIIHVACGE 93

Query: 499 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 320
            HS AL+  G++++WG G  G+LG    + S  VP  +Q L  + I+QVSCG  H + L 
Sbjct: 94  SHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALA 153

Query: 319 SDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTL 140
           +DG+ F++                G   E P    P +   S EG+  A  VA GG H+ 
Sbjct: 154 ADGQFFTWGKNSHG--------QLGLGKEFPSQASPQRV-RSLEGIPLAQ-VAAGGAHSF 203

Query: 139 AI 134
           A+
Sbjct: 204 AL 205



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 48/162 (29%), Positives = 76/162 (46%), Gaps = 2/162 (1%)
 Frame = -2

Query: 613 WGNNEYGQLGIGDTQPR--SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 440
           WG    GQ GI        ++P     +S+ S+ ++A GG HS  L ++GEVY  G    
Sbjct: 4   WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63

Query: 439 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 260
           G+LG   + +    P Q+  LA + I+ V+CG +HS+ L+  G++FS+            
Sbjct: 64  GQLGHEREGNK---PEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGL-- 118

Query: 259 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 134
            +TT   + VP  +      T  +       V+CG  H LA+
Sbjct: 119 -MTTEDSVAVPRLIQKLNQQTILQ-------VSCGNWHCLAL 152

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>HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4912

 Score =  105 bits (263), Expect = 1e-22
 Identities = 61/151 (40%), Positives = 90/151 (59%), Gaps = 6/151 (3%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQ--VSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR 563
            G   N+  P ++  L Q  V  +AV  G  H LAL++D  +++WG  E G+LG G+    
Sbjct: 3054 GVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTL 3113

Query: 562  SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
             +P  VE L    + D+A G  HSAA++ +GE+Y WG GE+GRLG GD+ ++ + P  V 
Sbjct: 3114 DKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDN-TTQLKPKLVT 3172

Query: 382  LLAGEDIVQVSCGG--THSVVLTSDGRIFSY 296
             LAG  +VQV+CG     ++ LT DG +FS+
Sbjct: 3173 ALAGRRVVQVACGSRDAQTLALTEDGAVFSW 3203



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 50/132 (37%), Positives = 76/132 (57%), Gaps = 4/132 (3%)
 Frame = -2

Query: 679  VSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 506
            V  +AV  G  H LAL+ +  ++AWG  E G+LG G+     +P  VE L+ +S+ DIA 
Sbjct: 4136 VKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIAC 4195

Query: 505  GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THS 332
            G  HSAA+T  G V  WG+G +GRLG GD +   + P  V+ L G   + ++CG     +
Sbjct: 4196 GSAHSAAITASGHVLTWGKGRYGRLGHGDSE-DQLRPKLVEALLGYRAIDIACGSGDAQT 4254

Query: 331  VVLTSDGRIFSY 296
            + +T D  ++S+
Sbjct: 4255 LCITDDDNVWSW 4266



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 58/205 (28%), Positives = 93/205 (45%), Gaps = 4/205 (1%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAV----GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR 563
            GD ++   P  V+ L     I +    G    L ++ D  +W+WG+ +YG+LG G +   
Sbjct: 4223 GDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGC 4282

Query: 562  SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
              P ++E L+ L +V +  G   S ALTK G VY WG+G+  RLG G        P +V 
Sbjct: 4283 KLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRR-PKKVA 4341

Query: 382  LLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKT 203
             L G+ I+ ++ G  H V  +  G ++++            +   G      I  P    
Sbjct: 4342 ALQGKKIISIATGSLHCVACSDSGEVYTW--------GDNDEGQLGDGTVTAIQRPRLVA 4393

Query: 202  STSSEGLWQANYVACGGRHTLAIVT 128
            +   + + +   V CG  HTLA+ T
Sbjct: 4394 ALQGKHIVK---VTCGSAHTLALST 4415



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 49/149 (32%), Positives = 82/149 (55%), Gaps = 4/149 (2%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSM--IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            G+  +   P  V+ L  +S+  IA G+ H+ A++    +  WG   YG+LG GD++ + +
Sbjct: 4171 GNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLR 4230

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAAL--TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
            P  VE L     +DIA G   +  L  T +  V++WG G++G+LG G      + P +++
Sbjct: 4231 PKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKL-PYKIE 4289

Query: 382  LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
             LAG  +V+V CG   SV LT  G ++++
Sbjct: 4290 SLAGLGVVKVECGSQFSVALTKSGAVYTW 4318



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 53/149 (35%), Positives = 85/149 (57%), Gaps = 4/149 (2%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQ--VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            GD    + P ++  LEQ  V  +  G  ++ A++    L  WG   Y +LG G++  RS 
Sbjct: 651  GDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSL 710

Query: 556  PIRVEGLSNLSLVDIA--AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
            P  V  LS+  +VD+A  +G  HS ALT EG V+AWG G++G+LG G+   S + P+ V+
Sbjct: 711  PTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGS-LQPILVE 769

Query: 382  LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
             L    + +V  G   SV L+S+G+++++
Sbjct: 770  SL--PRVQRVFAGSQFSVALSSEGQLYTW 796



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 43/131 (32%), Positives = 76/131 (58%), Gaps = 2/131 (1%)
 Frame = -2

Query: 682  QVSMIAVGA--FHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 509
            +V  +A G+     LAL+ D  +++WG+ ++G+LG G ++    P  +E LS + +V I 
Sbjct: 3178 RVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIE 3237

Query: 508  AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
             G   S ALT+ GEV+ WG+G++ RLG G D+     P  +  L G  ++ V+ G  H +
Sbjct: 3238 CGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRK-PQPIGGLRGRRVIHVAVGALHCL 3296

Query: 328  VLTSDGRIFSY 296
             +T  G+++++
Sbjct: 3297 AVTDAGQVYAW 3307



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 45/139 (32%), Positives = 73/139 (52%), Gaps = 5/139 (3%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            G  +   TP  ++ L  + ++ +  GA  +LAL+    +W WG  +Y +LG G  Q   +
Sbjct: 3214 GGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRK 3273

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 377
            P  + GL    ++ +A G  H  A+T  G+VYAWG  +HG+ G G+      V  +  L+
Sbjct: 3274 PQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNT----FVNKKPALV 3329

Query: 376  AGEDIV---QVSCGGTHSV 329
             G D V   +V+CG +HS+
Sbjct: 3330 IGLDAVFVNRVACGSSHSI 3348



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 44/123 (35%), Positives = 68/123 (55%), Gaps = 4/123 (3%)
 Frame = -2

Query: 652 HNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKE 473
           H LA+  +   ++WG  E  +LG GDT  R+ P ++  L    +  +  G  +SAA+T  
Sbjct: 627 HFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCG 686

Query: 472 GEVYAWGRGEHGRLGFG--DDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGRI 305
           G +  WGRG + RLG G  DD+S   +P  V  L+   +V V+ G    HS+ LTS+G +
Sbjct: 687 GNLLTWGRGTYARLGHGNSDDRS---LPTLVVALSDHMVVDVALGSGDAHSLALTSEGLV 743

Query: 304 FSY 296
           F++
Sbjct: 744 FAW 746



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 42/127 (33%), Positives = 73/127 (57%), Gaps = 2/127 (1%)
 Frame = -2

Query: 670  IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA--AGGW 497
            IA G+     +S D  ++A G    G+LG+G T     P ++  L    +  +A  +GG 
Sbjct: 3024 IAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGK 3083

Query: 496  HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 317
            H+ ALT +G+V++WG GE G+LG G ++++   P  V+ L  + I  V+CG +HS  ++S
Sbjct: 3084 HALALTLDGKVFSWGEGEDGKLGHG-NRTTLDKPRLVEALRAKKIRDVACGSSHSAAISS 3142

Query: 316  DGRIFSY 296
             G ++++
Sbjct: 3143 QGELYTW 3149



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 49/150 (32%), Positives = 74/150 (49%), Gaps = 5/150 (3%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAV----GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR 563
            G+  + S P  V  L    ++ V    G  H+LAL+ + +++AWG+ +YG+LG G+    
Sbjct: 703  GNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGS 762

Query: 562  SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE-HGRLGFGDDKSSHMVPLQV 386
             QPI VE L  +  V   AG   S AL+ EG++Y WG+    G            VP  V
Sbjct: 763  LQPILVESLPRVQRV--FAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLV 820

Query: 385  QLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
              L  + IV V+    H + L+S G +F +
Sbjct: 821  SSLQHKRIVDVAVSVAHCLALSSSGEVFGW 850



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 2/165 (1%)
 Frame = -2

Query: 622  LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 443
            ++ WG+N  GQLG  +      P   E LS L  V +A G     A+T +G+++A G G 
Sbjct: 4051 IYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGS 4110

Query: 442  HGRLGFGDDKSSHMVPLQVQLLAGEDI--VQVSCGGTHSVVLTSDGRIFSYXXXXXXXXX 269
             GRLG G    S  +P  +  L    +  V V+ GG H + LT++G ++++         
Sbjct: 4111 GGRLGVG-GSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAW------GEG 4163

Query: 268  XXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 134
               K+  G+ M    +   PK      G+  A+ +ACG  H+ AI
Sbjct: 4164 EDGKLGHGNRM----SYDRPKLVEHLNGMSVAD-IACGSAHSAAI 4203



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 50/164 (30%), Positives = 70/164 (42%), Gaps = 4/164 (2%)
 Frame = -2

Query: 613  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 434
            WG N+  QLG         P   + +S L  + IA G      ++++G+VYA G G +GR
Sbjct: 2991 WGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGR 3050

Query: 433  LGFGDDKSSHMVPLQVQLLAGEDI----VQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXX 266
            LG G    +H VPL  QL          V V  GG H++ LT DG++FS+          
Sbjct: 3051 LGLG---VTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGH 3107

Query: 265  XRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 134
              + T   P  V            +    +   VACG  H+ AI
Sbjct: 3108 GNRTTLDKPRLV-----------EALRAKKIRDVACGSSHSAAI 3140



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 30/84 (35%), Positives = 48/84 (57%), Gaps = 2/84 (2%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            G  +++  P  + GL   +V  +AVGA H LA++    ++AWG+N++GQ G G+T    +
Sbjct: 3266 GGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKK 3325

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAA 485
            P  V GL  + +  +A G  HS A
Sbjct: 3326 PALVIGLDAVFVNRVACGSSHSIA 3349



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 2/131 (1%)
 Frame = -2

Query: 682 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG 503
           Q+  +A      L LS +  L+ W             +P ++P+ +E +++   + IA  
Sbjct: 573 QIKQVACCETQMLILSQEGKLYTWRL----------AKPEAEPLPMEEVAHDVFISIAGH 622

Query: 502 --GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
             G H  A+      Y+WG GE  RLG G D  +  VP ++  L    +  V CG ++S 
Sbjct: 623 CEGRHFLAIDSNHNAYSWGTGEDHRLGHG-DTHARAVPTKIAALEQHCVQSVYCGCSYSA 681

Query: 328 VLTSDGRIFSY 296
            +T  G + ++
Sbjct: 682 AITCGGNLLTW 692



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 31/98 (31%), Positives = 47/98 (47%), Gaps = 2/98 (2%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEY--GQLGIGDTQPRSQ 557
            G+      P+ V+ L +V  +  G+  ++ALS +  L+ WG       QL     Q  S 
Sbjct: 757  GNCNGSLQPILVESLPRVQRVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSV 816

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 443
            P  V  L +  +VD+A    H  AL+  GEV+ WGR +
Sbjct: 817  PRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRND 854

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>HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing protein 5|
           (Cyclin-E-binding protein 1)
          Length = 1024

 Score =  104 bits (259), Expect = 3e-22
 Identities = 54/142 (38%), Positives = 88/142 (61%), Gaps = 3/142 (2%)
 Frame = -2

Query: 712 STPVRVQGLEQVSM--IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG 539
           +TP  V+ L  V +  I+ G  H++ALS+   +++WG NE GQLG+G T+ +  P  +EG
Sbjct: 180 TTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEG 239

Query: 538 LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV 359
           L N  +  +A GG HSA LT++G ++ +G G+HG+LG  +   + + P  V  L G  + 
Sbjct: 240 LDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGH-NSTQNELRPCLVAELVGYRVT 298

Query: 358 QVSCGGTHSVVLTSD-GRIFSY 296
           Q++CG  H++   SD G++FS+
Sbjct: 299 QIACGRWHTLAYVSDLGKVFSF 320



 Score =  101 bits (252), Expect = 2e-21
 Identities = 63/187 (33%), Positives = 96/187 (51%), Gaps = 1/187 (0%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQP-RSQPIRVEGLSNLSLVDIA 509
           +++  I  G +H+LALS    L+AWG N +GQLG+G   P  + P  VE L+ + L  I+
Sbjct: 138 KKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQIS 197

Query: 508 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
           AG  HS AL+  G +Y+WG+ E G+LG G  +S    P  ++ L  + +  V+CGG+HS 
Sbjct: 198 AGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKD-DPSLIEGLDNQKVEFVACGGSHSA 256

Query: 328 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGR 149
           +LT DG +F++                  P  V   +            ++   +ACG  
Sbjct: 257 LLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVG-----------YRVTQIACGRW 305

Query: 148 HTLAIVT 128
           HTLA V+
Sbjct: 306 HTLAYVS 312



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 54/182 (29%), Positives = 80/182 (43%), Gaps = 2/182 (1%)
 Frame = -2

Query: 682 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG 503
           ++  +  GA H L LS D   + + N     L       R + I    L    ++ I  G
Sbjct: 98  KIHSVDQGAEHMLILSSDGKPFEYDNYSMKHL-------RFESI----LQEKKIIQITCG 146

Query: 502 GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 323
            +HS AL+K GE++AWG+  HG+LG G    S   P  V+ LAG  + Q+S G  HS+ L
Sbjct: 147 DYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMAL 206

Query: 322 TSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGL--WQANYVACGGR 149
           +  G I+S+              +   P  +             EGL   +  +VACGG 
Sbjct: 207 SMSGNIYSWGKNECGQLGLGHTESKDDPSLI-------------EGLDNQKVEFVACGGS 253

Query: 148 HT 143
           H+
Sbjct: 254 HS 255

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>HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4834

 Score =  103 bits (258), Expect = 4e-22
 Identities = 54/151 (35%), Positives = 89/151 (58%), Gaps = 6/151 (3%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAV----GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR 563
            G  +++STP  ++ ++ V +  V    G  H LALS +  +++WG  E G+LG G+  P 
Sbjct: 4020 GGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPC 4079

Query: 562  SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
             +P  +E L  + +VD+AAGG HSA +T  G++Y WG+G +GRLG  D +   + P  V+
Sbjct: 4080 DRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSE-DQLKPKLVE 4138

Query: 382  LLAGEDIVQVSCGG--THSVVLTSDGRIFSY 296
             L G  +V ++CG     ++ LT D  ++S+
Sbjct: 4139 ALQGHRVVDIACGSGDAQTLCLTDDDTVWSW 4169



 Score =  102 bits (254), Expect = 1e-21
 Identities = 58/175 (33%), Positives = 89/175 (50%)
 Frame = -2

Query: 661  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 482
            G    L L+ D  +W+WG+ +YG+LG G +     P++++ L+ L +V +  G   S AL
Sbjct: 4153 GDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVAL 4212

Query: 481  TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 302
            TK G VY WG+G++ RLG G D      P QVQ L G+ ++ ++ G  H V  T DG ++
Sbjct: 4213 TKSGAVYTWGKGDYHRLGHGSDDHVRR-PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVY 4271

Query: 301  SYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLA 137
            ++              TT         +  P+   + +G  + N VACG  HTLA
Sbjct: 4272 TWGDNDEGQLGDG---TTN-------AIQRPRLVAALQGK-KVNRVACGSAHTLA 4315



 Score =  100 bits (249), Expect = 5e-21
 Identities = 65/194 (33%), Positives = 99/194 (51%), Gaps = 8/194 (4%)
 Frame = -2

Query: 679  VSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 506
            V  +AV  G  H  AL+VD  +++WG  + G+LG        +P  +E L    + DIA 
Sbjct: 3047 VKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIAC 3106

Query: 505  GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THS 332
            G  HSAALT  GE+Y WG GE+GRLG GD+ ++ + P  V++L G  ++QV+CG     +
Sbjct: 3107 GSSHSAALTSSGELYTWGLGEYGRLGHGDN-TTQLKPKMVKVLLGHRVIQVACGSRDAQT 3165

Query: 331  VVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGG 152
            + LT +G +FS+                G       N+P      + +G+ Q   + CG 
Sbjct: 3166 LALTDEGLVFSWGDGDFG--------KLGRGGSEGCNIPQNIERLNGQGVCQ---IECGA 3214

Query: 151  RHTLAI----VTWT 122
            + +LA+    V WT
Sbjct: 3215 QFSLALTKSGVVWT 3228



 Score =  100 bits (249), Expect = 5e-21
 Identities = 54/172 (31%), Positives = 93/172 (54%), Gaps = 4/172 (2%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAV----GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR 563
            G  ++ + P+ V GL+ + +I V    G    LA++ +  +W+WG+ +YG+LG G +   
Sbjct: 586  GSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC 645

Query: 562  SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
              P  +E L +L +V +  G   S ALTK+G+VY+WG+G++ RLG G ++     P  ++
Sbjct: 646  KTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVR-YPKLLE 704

Query: 382  LLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVP 227
             L G+ ++ V+ G TH + LT D  + S+            +VT   P  +P
Sbjct: 705  GLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALP 756



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 46/135 (34%), Positives = 80/135 (59%), Gaps = 2/135 (1%)
 Frame = -2

Query: 694 QGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVD 515
           Q  + V  IA G+ ++ A++ +  L+ WG   YG+LG G ++  + P+ V GL  L ++D
Sbjct: 548 QAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVID 607

Query: 514 IAAGGW--HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG 341
           +A G     + A+T+ G+V++WG G++G+LG G        P  ++ L   D+V+V CG 
Sbjct: 608 VACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC-KTPKLIEKLQDLDVVKVRCGS 666

Query: 340 THSVVLTSDGRIFSY 296
             S+ LT DG+++S+
Sbjct: 667 QFSIALTKDGQVYSW 681



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 51/140 (36%), Positives = 76/140 (54%), Gaps = 2/140 (1%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            G  +  + P  ++ L  + V  I  GA  +LAL+   ++W WG  +Y +LG G      +
Sbjct: 3188 GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRK 3247

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 377
            P  VEGL    +V +A G  H  A+T  G+VYAWG  +HG+ G G   + +  P  VQ L
Sbjct: 3248 PQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNG-TTTVNRKPTLVQGL 3306

Query: 376  AGEDIVQVSCGGTHSVVLTS 317
             G+ I +V+CG +HSV  T+
Sbjct: 3307 EGQKITRVACGSSHSVAWTT 3326



 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 47/136 (34%), Positives = 77/136 (56%), Gaps = 2/136 (1%)
 Frame = -2

Query: 697  VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 518
            ++G+E V + A GA H+  ++    L+ WG   YG+LG  D++ + +P  VE L    +V
Sbjct: 4088 LRGIEVVDVAAGGA-HSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV 4146

Query: 517  DIAAGGW--HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCG 344
            DIA G     +  LT +  V++WG G++G+LG G       VP+++  L G  +V+V CG
Sbjct: 4147 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC-KVPMKIDSLTGLGVVKVECG 4205

Query: 343  GTHSVVLTSDGRIFSY 296
               SV LT  G ++++
Sbjct: 4206 SQFSVALTKSGAVYTW 4221



 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 57/199 (28%), Positives = 97/199 (48%), Gaps = 4/199 (2%)
 Frame = -2

Query: 718  NISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV 545
            N   P  ++ L+  ++  IA G+ H+ AL+    L+ WG  EYG+LG GD   + +P  V
Sbjct: 3086 NCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMV 3145

Query: 544  EGLSNLSLVDIAAGG--WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAG 371
            + L    ++ +A G     + ALT EG V++WG G+ G+LG G  +  + +P  ++ L G
Sbjct: 3146 KVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCN-IPQNIERLNG 3204

Query: 370  EDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSS 191
            + + Q+ CG   S+ LT  G ++++                GH  +V +  P        
Sbjct: 3205 QGVCQIECGAQFSLALTKSGVVWTWGKGDY--------FRLGHGSDVHVRKPQVVEGLRG 3256

Query: 190  EGLWQANYVACGGRHTLAI 134
            +   +  +VA G  H LA+
Sbjct: 3257 K---KIVHVAVGALHCLAV 3272



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 54/189 (28%), Positives = 91/189 (48%), Gaps = 4/189 (2%)
 Frame = -2

Query: 682  QVSMIAVGA--FHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 509
            +V  +A G+     LAL+ + ++++WG+ ++G+LG G ++  + P  +E L+   +  I 
Sbjct: 3152 RVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIE 3211

Query: 508  AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
             G   S ALTK G V+ WG+G++ RLG G D      P  V+ L G+ IV V+ G  H +
Sbjct: 3212 CGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRK-PQVVEGLRGKKIVHVAVGALHCL 3270

Query: 328  VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGL--WQANYVACG 155
             +T  G+++++                  P             T  +GL   +   VACG
Sbjct: 3271 AVTDSGQVYAWGDNDHGQQGNGTTTVNRKP-------------TLVQGLEGQKITRVACG 3317

Query: 154  GRHTLAIVT 128
              H++A  T
Sbjct: 3318 SSHSVAWTT 3326



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 40/136 (29%), Positives = 70/136 (51%), Gaps = 2/136 (1%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            G       P+++  L  + ++ V  G+  ++AL+    ++ WG  +Y +LG G      +
Sbjct: 4180 GGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRR 4239

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 377
            P +V+GL    ++ IA G  H    T++GEVY WG  + G+LG G   +    P  V  L
Sbjct: 4240 PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR-PRLVAAL 4298

Query: 376  AGEDIVQVSCGGTHSV 329
             G+ + +V+CG  H++
Sbjct: 4299 QGKKVNRVACGSAHTL 4314



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 47/151 (31%), Positives = 76/151 (50%), Gaps = 10/151 (6%)
 Frame = -2

Query: 718 NISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG 539
           N+  P++ +GL  + +  +       L + R         Y Q    DT     P  V+G
Sbjct: 438 NVIGPIQCEGLANLGVTQIACAEKRFLILSR-----NGRVYTQAYNSDTLA---PQLVQG 489

Query: 538 LSNLSLVDIAA--GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL---- 377
           L++ ++V IAA   G H  AL   GEVY+WG G+ GRLG GD      VPL+   +    
Sbjct: 490 LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGD-----TVPLEEPKVISAF 544

Query: 376 ----AGEDIVQVSCGGTHSVVLTSDGRIFSY 296
               AG+ +V ++CG T+S  +T++G ++++
Sbjct: 545 SGKQAGKHVVHIACGSTYSAAITAEGELYTW 575



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 50/174 (28%), Positives = 78/174 (44%), Gaps = 2/174 (1%)
 Frame = -2

Query: 643  ALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEV 464
            A ++   ++ WG N+  QLG         P   E LS L++V +A G     A+T EG+V
Sbjct: 2954 AATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKV 3013

Query: 463  YAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDI--VQVSCGGTHSVVLTSDGRIFSYXX 290
            YA G   +GRLG G    +  +P Q+  L+   +  V V  GG H+  LT DG++FS+  
Sbjct: 3014 YACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGE 3073

Query: 289  XXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVT 128
                      ++    P  +       KT    +       +ACG  H+ A+ +
Sbjct: 3074 GDDGKLGHFSRMNCDKPRLI----EALKTKRIRD-------IACGSSHSAALTS 3116



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 54/163 (33%)
 Frame = -2

Query: 622  LWAWGNNEYGQ------------------------------------------------- 590
            ++ WG+N  GQ                                                 
Sbjct: 3954 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGA 4013

Query: 589  ---LGIGDTQPRSQPIRVEGLSNLSLVDIA--AGGWHSAALTKEGEVYAWGRGEHGRLGF 425
               LGIG T+  S P  +E + ++ +  +A  +GG H  AL+ EGEVY+WG  E G+LG 
Sbjct: 4014 GGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGH 4073

Query: 424  GDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
            G ++S    P  ++ L G ++V V+ GG HS  +T+ G ++++
Sbjct: 4074 G-NRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTW 4115



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 2/84 (2%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            G   ++  P +VQGL+  +V  IA G+ H +  + D  ++ WG+N+ GQLG G T    +
Sbjct: 4232 GSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR 4291

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAA 485
            P  V  L    +  +A G  H+ A
Sbjct: 4292 PRLVAALQGKKVNRVACGSAHTLA 4315

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>HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4836

 Score =  103 bits (257), Expect = 5e-22
 Identities = 53/151 (35%), Positives = 89/151 (58%), Gaps = 6/151 (3%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAV----GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR 563
            G  +++STP  ++ ++ V +  V    G  H LALS +  +++WG  E G+LG G+  P 
Sbjct: 4022 GGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPC 4081

Query: 562  SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
             +P  +E L  + +VD+AAGG HSA +T  G++Y WG+G +GRLG  D +   + P  V+
Sbjct: 4082 DRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSE-DQLKPKLVE 4140

Query: 382  LLAGEDIVQVSCGG--THSVVLTSDGRIFSY 296
             L G  ++ ++CG     ++ LT D  ++S+
Sbjct: 4141 ALQGHRVIDIACGSGDAQTLCLTDDDTVWSW 4171



 Score =  102 bits (254), Expect = 1e-21
 Identities = 58/175 (33%), Positives = 89/175 (50%)
 Frame = -2

Query: 661  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 482
            G    L L+ D  +W+WG+ +YG+LG G +     P++++ L+ L +V +  G   S AL
Sbjct: 4155 GDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVAL 4214

Query: 481  TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 302
            TK G VY WG+G++ RLG G D      P QVQ L G+ ++ ++ G  H V  T DG ++
Sbjct: 4215 TKSGAVYTWGKGDYHRLGHGSDDHVRR-PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVY 4273

Query: 301  SYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLA 137
            ++              TT         +  P+   + +G  + N VACG  HTLA
Sbjct: 4274 TWGDNDEGQLGDG---TTN-------AIQRPRLVAALQGK-KVNRVACGSAHTLA 4317



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 54/172 (31%), Positives = 92/172 (53%), Gaps = 4/172 (2%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAV----GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR 563
            G  ++ + P+ V GL+ + +I V    G    LA++ +  +W+WG+ +YG+LG G +   
Sbjct: 587  GSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC 646

Query: 562  SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
              P  +E L +L ++ +  G   S ALTK+G+VY+WG+G++ RLG G ++     P  ++
Sbjct: 647  KTPKLIEKLQDLDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVR-YPKLLE 705

Query: 382  LLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVP 227
             L G+ ++ V+ G TH +VLT D  + S+             VT   P   P
Sbjct: 706  GLQGKKVIDVAAGSTHCLVLTEDSEVHSWGSNDQCQHFDTLGVTKPEPTAFP 757



 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 63/194 (32%), Positives = 98/194 (50%), Gaps = 8/194 (4%)
 Frame = -2

Query: 679  VSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 506
            V  +AV  G  H  AL+VD  +++WG  + G+LG        +P  ++ L    + DIA 
Sbjct: 3048 VKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIQALKTKRIRDIAY 3107

Query: 505  GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THS 332
            G  HSA LT  GE+Y WG GE+GRLG GD+ ++ + P  V++L G  ++QV+CG     +
Sbjct: 3108 GSSHSAPLTSSGELYTWGLGEYGRLGHGDN-TTQLKPKMVKVLLGHRVIQVACGSRDAQT 3166

Query: 331  VVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGG 152
            + LT +G +FS+                G       N+P      + +G+ Q   + CG 
Sbjct: 3167 LALTDEGLVFSWGDGDFG--------KLGRGGSEGCNIPQNIERLNGQGVCQ---IECGA 3215

Query: 151  RHTLAI----VTWT 122
            + +LA+    V WT
Sbjct: 3216 QFSLALTKSGVVWT 3229



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 45/135 (33%), Positives = 80/135 (59%), Gaps = 2/135 (1%)
 Frame = -2

Query: 694 QGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVD 515
           Q  + V  IA G+ ++ A++ +  L+ WG   YG+LG G ++  + P+ V GL  L ++D
Sbjct: 549 QAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVID 608

Query: 514 IAAGGW--HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG 341
           +A G     + A+T+ G+V++WG G++G+LG G        P  ++ L   D+++V CG 
Sbjct: 609 VACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC-KTPKLIEKLQDLDVIKVRCGS 667

Query: 340 THSVVLTSDGRIFSY 296
             S+ LT DG+++S+
Sbjct: 668 QFSIALTKDGQVYSW 682



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 51/140 (36%), Positives = 76/140 (54%), Gaps = 2/140 (1%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            G  +  + P  ++ L  + V  I  GA  +LAL+   ++W WG  +Y +LG G      +
Sbjct: 3189 GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRK 3248

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 377
            P  VEGL    +V +A G  H  A+T  G+VYAWG  +HG+ G G   + +  P  VQ L
Sbjct: 3249 PQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNG-TTTVNRKPTLVQGL 3307

Query: 376  AGEDIVQVSCGGTHSVVLTS 317
             G+ I +V+CG +HSV  T+
Sbjct: 3308 EGQKITRVACGSSHSVAWTT 3327



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 46/136 (33%), Positives = 77/136 (56%), Gaps = 2/136 (1%)
 Frame = -2

Query: 697  VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 518
            ++G+E V + A GA H+  ++    L+ WG   YG+LG  D++ + +P  VE L    ++
Sbjct: 4090 LRGIEVVDVAAGGA-HSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVI 4148

Query: 517  DIAAGGW--HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCG 344
            DIA G     +  LT +  V++WG G++G+LG G       VP+++  L G  +V+V CG
Sbjct: 4149 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC-KVPMKIDSLTGLGVVKVECG 4207

Query: 343  GTHSVVLTSDGRIFSY 296
               SV LT  G ++++
Sbjct: 4208 SQFSVALTKSGAVYTW 4223



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 57/199 (28%), Positives = 96/199 (48%), Gaps = 4/199 (2%)
 Frame = -2

Query: 718  NISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV 545
            N   P  +Q L+  ++  IA G+ H+  L+    L+ WG  EYG+LG GD   + +P  V
Sbjct: 3087 NCDKPRLIQALKTKRIRDIAYGSSHSAPLTSSGELYTWGLGEYGRLGHGDNTTQLKPKMV 3146

Query: 544  EGLSNLSLVDIAAGG--WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAG 371
            + L    ++ +A G     + ALT EG V++WG G+ G+LG G  +  + +P  ++ L G
Sbjct: 3147 KVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCN-IPQNIERLNG 3205

Query: 370  EDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSS 191
            + + Q+ CG   S+ LT  G ++++                GH  +V +  P        
Sbjct: 3206 QGVCQIECGAQFSLALTKSGVVWTWGKGDY--------FRLGHGSDVHVRKPQVVEGLRG 3257

Query: 190  EGLWQANYVACGGRHTLAI 134
            +   +  +VA G  H LA+
Sbjct: 3258 K---KIVHVAVGALHCLAV 3273



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 54/189 (28%), Positives = 91/189 (48%), Gaps = 4/189 (2%)
 Frame = -2

Query: 682  QVSMIAVGA--FHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 509
            +V  +A G+     LAL+ + ++++WG+ ++G+LG G ++  + P  +E L+   +  I 
Sbjct: 3153 RVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIE 3212

Query: 508  AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
             G   S ALTK G V+ WG+G++ RLG G D      P  V+ L G+ IV V+ G  H +
Sbjct: 3213 CGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRK-PQVVEGLRGKKIVHVAVGALHCL 3271

Query: 328  VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGL--WQANYVACG 155
             +T  G+++++                  P             T  +GL   +   VACG
Sbjct: 3272 AVTDSGQVYAWGDNDHGQQGNGTTTVNRKP-------------TLVQGLEGQKITRVACG 3318

Query: 154  GRHTLAIVT 128
              H++A  T
Sbjct: 3319 SSHSVAWTT 3327



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 40/136 (29%), Positives = 70/136 (51%), Gaps = 2/136 (1%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            G       P+++  L  + ++ V  G+  ++AL+    ++ WG  +Y +LG G      +
Sbjct: 4182 GGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRR 4241

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 377
            P +V+GL    ++ IA G  H    T++GEVY WG  + G+LG G   +    P  V  L
Sbjct: 4242 PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR-PRLVAAL 4300

Query: 376  AGEDIVQVSCGGTHSV 329
             G+ + +V+CG  H++
Sbjct: 4301 QGKKVNRVACGSAHTL 4316



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 47/151 (31%), Positives = 76/151 (50%), Gaps = 10/151 (6%)
 Frame = -2

Query: 718 NISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG 539
           N+  P++ +GL  + ++ V       L + R         Y Q    D      P  V+G
Sbjct: 439 NVIGPIQCEGLASLGVMQVACAEKRFLILSR-----NGRVYTQAYNSDMLA---PQLVQG 490

Query: 538 LSNLSLVDIAA--GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL---- 377
           L++ ++V IAA   G H  AL   GEVY+WG G+ GRLG GD      VPL+   +    
Sbjct: 491 LASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGD-----TVPLEEPKVISAF 545

Query: 376 ----AGEDIVQVSCGGTHSVVLTSDGRIFSY 296
               AG+ +V ++CG T+S  +T++G ++++
Sbjct: 546 SGKQAGKHVVHIACGSTYSAAITAEGELYTW 576



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 40/111 (36%), Positives = 59/111 (53%), Gaps = 2/111 (1%)
 Frame = -2

Query: 622  LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 443
            ++ WG N+  QLG         P   E LS L++V +A G     A+T EG+VY+ G   
Sbjct: 2962 VFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYSCGEAT 3021

Query: 442  HGRLGFGDDKSSHMVPLQVQLLAGEDI--VQVSCGGTHSVVLTSDGRIFSY 296
            +GRLG G    +  +P Q+  L+   +  V V  GG H+  LT DG++FS+
Sbjct: 3022 NGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSW 3072



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 54/163 (33%)
 Frame = -2

Query: 622  LWAWGNNEYGQ------------------------------------------------- 590
            ++ WG+N  GQ                                                 
Sbjct: 3956 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGA 4015

Query: 589  ---LGIGDTQPRSQPIRVEGLSNLSLVDIA--AGGWHSAALTKEGEVYAWGRGEHGRLGF 425
               LGIG T+  S P  +E + ++ +  +A  +GG H  AL+ EGEVY+WG  E G+LG 
Sbjct: 4016 GGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGH 4075

Query: 424  GDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
            G ++S    P  ++ L G ++V V+ GG HS  +T+ G ++++
Sbjct: 4076 G-NRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTW 4117



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 2/84 (2%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            G   ++  P +VQGL+  +V  IA G+ H +  + D  ++ WG+N+ GQLG G T    +
Sbjct: 4234 GSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR 4293

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAA 485
            P  V  L    +  +A G  H+ A
Sbjct: 4294 PRLVAALQGKKVNRVACGSAHTLA 4317

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>RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 54/155 (34%), Positives = 84/155 (54%), Gaps = 1/155 (0%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIA 509
           +QV  +A G++H+L L+ D  ++AWG N  GQ+G G T  +  P RV G L N  +++IA
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIA 211

Query: 508 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
            G   S A+   GEVY WG   +G+LG G    +   P +V  L G  + +V+CG  H++
Sbjct: 212 CGQMCSMAVVDTGEVYVWGYNGNGQLGLGSS-GNQPTPCRVAALQGIRVQRVACGYAHTL 270

Query: 328 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPI 224
           VLT +G+I+++            K    +P  V +
Sbjct: 271 VLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVV 305



 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 53/203 (26%), Positives = 96/203 (47%), Gaps = 4/203 (1%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRS 560
           GDI++   P R+  L  ++++ ++ G+  ++ L+  D  ++ WG+N Y QLG G T    
Sbjct: 81  GDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGL 140

Query: 559 QPIRVE-GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
            P  +   LSN  ++++A G +HS  LT +GEV+AWG    G++G G   +  +      
Sbjct: 141 VPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTG 200

Query: 382 LLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKT 203
            L  + ++ ++CG   S+ +   G ++ +                        N P P  
Sbjct: 201 CLQNKVVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSG----------NQPTPCR 250

Query: 202 STSSEGLWQANYVACGGRHTLAI 134
             + +G+ +   VACG  HTL +
Sbjct: 251 VAALQGI-RVQRVACGYAHTLVL 272



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 54/200 (27%), Positives = 95/200 (47%), Gaps = 2/200 (1%)
 Frame = -2

Query: 724 IKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV 545
           I ++ +   +Q + Q  +        L  +V+  ++  G N  G LG+GD Q   +P R+
Sbjct: 33  IFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTIEPRRL 92

Query: 544 EGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL-LAG 371
           + L+   +  ++ G G H    T +GEV+ WG   + +LG G      +VP  +   L+ 
Sbjct: 93  DSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHG-LVPCHISTNLSN 151

Query: 370 EDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSS 191
           + +++V+CG  HS+VLTSDG +F++            +V +G     PI    P+  T  
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAW------GYNNSGQVGSGSTANQPI----PRRVTGC 201

Query: 190 EGLWQANYVACGGRHTLAIV 131
                   +ACG   ++A+V
Sbjct: 202 LQNKVVMNIACGQMCSMAVV 221



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 49/149 (32%), Positives = 72/149 (48%), Gaps = 4/149 (2%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLEQ---VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 560
           G   N   P RV G  Q   V  IA G   ++A+     ++ WG N  GQLG+G +  + 
Sbjct: 187 GSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQP 246

Query: 559 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 380
            P RV  L  + +  +A G  H+  LT EG++YAWG   +G+LG G +KS+   P  V +
Sbjct: 247 TPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTG-NKSNQSYPTPVVV 305

Query: 379 LAGEDIVQVSCGGTH-SVVLTSDGRIFSY 296
                I   +C   H S   T  G ++ +
Sbjct: 306 EKDRIIEIAACHSAHTSAAKTQGGHVYMW 334



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 38/98 (38%), Positives = 53/98 (54%), Gaps = 4/98 (4%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
           G   N  TP RV  L+  +V  +A G  H L L+ +  ++AWG N YGQLG G+   +S 
Sbjct: 240 GSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSY 299

Query: 556 PIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGR 449
           P  V  +    +++IAA      SAA T+ G VY WG+
Sbjct: 300 PTPVV-VEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQ 336

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>RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 54/155 (34%), Positives = 83/155 (53%), Gaps = 1/155 (0%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIA 509
           +QV  +A G++H+L L+ D  ++AWG N  GQ+G G T  +  P RV G L N  ++ IA
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIA 211

Query: 508 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
            G   S A+   GEVY WG   +G+LG G    +   P +V  L G  + +V+CG  H++
Sbjct: 212 CGQMCSMAVVDTGEVYVWGYNGNGQLGLGSS-GNQPTPCRVAALQGIRVQRVACGYAHTL 270

Query: 328 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPI 224
           VLT +G+I+++            K    +P  V +
Sbjct: 271 VLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVV 305



 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 53/203 (26%), Positives = 96/203 (47%), Gaps = 4/203 (1%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRS 560
           GDI++   P R+  L  ++++ ++ G+  ++ L+  D  ++ WG+N Y QLG G T    
Sbjct: 81  GDIQSTIEPRRLDSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHGL 140

Query: 559 QPIRVE-GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
            P  +   LSN  ++++A G +HS  LT +GEV+AWG    G++G G   +  +      
Sbjct: 141 VPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTG 200

Query: 382 LLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKT 203
            L  + ++ ++CG   S+ +   G ++ +                        N P P  
Sbjct: 201 CLQNKVVMSIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSG----------NQPTPCR 250

Query: 202 STSSEGLWQANYVACGGRHTLAI 134
             + +G+ +   VACG  HTL +
Sbjct: 251 VAALQGI-RVQRVACGYAHTLVL 272



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 54/200 (27%), Positives = 95/200 (47%), Gaps = 2/200 (1%)
 Frame = -2

Query: 724 IKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV 545
           I ++ +   +Q + Q  +        L  +V+  ++  G N  G LG+GD Q   +P R+
Sbjct: 33  IFSLCSEEELQLIRQACVFGTAGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTIEPRRL 92

Query: 544 EGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL-LAG 371
           + L+   +  ++ G G H    T +GEV+ WG   + +LG G      +VP  +   L+ 
Sbjct: 93  DSLTGKKIASLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHG-LVPCHISTNLSN 151

Query: 370 EDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSS 191
           + +++V+CG  HS+VLTSDG +F++            +V +G     PI    P+  T  
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAW------GYNNSGQVGSGSTANQPI----PRRVTGC 201

Query: 190 EGLWQANYVACGGRHTLAIV 131
                   +ACG   ++A+V
Sbjct: 202 LQNKVVMSIACGQMCSMAVV 221



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 48/143 (33%), Positives = 69/143 (48%), Gaps = 3/143 (2%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLEQ---VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 560
           G   N   P RV G  Q   V  IA G   ++A+     ++ WG N  GQLG+G +  + 
Sbjct: 187 GSTANQPIPRRVTGCLQNKVVMSIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQP 246

Query: 559 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 380
            P RV  L  + +  +A G  H+  LT EG++YAWG   +G+LG G +KS+   P  V +
Sbjct: 247 TPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTG-NKSNQSYPTPVVV 305

Query: 379 LAGEDIVQVSCGGTHSVVLTSDG 311
                I   +C   H+    S G
Sbjct: 306 EKDRIIEIAACHSAHTSAAKSQG 328



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 37/98 (37%), Positives = 53/98 (54%), Gaps = 4/98 (4%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
           G   N  TP RV  L+  +V  +A G  H L L+ +  ++AWG N YGQLG G+   +S 
Sbjct: 240 GSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSY 299

Query: 556 PIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGR 449
           P  V  +    +++IAA      SAA ++ G VY WG+
Sbjct: 300 PTPVV-VEKDRIIEIAACHSAHTSAAKSQGGHVYMWGQ 336

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>RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2)
          Length = 551

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 53/155 (34%), Positives = 83/155 (53%), Gaps = 1/155 (0%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIA 509
           +QV  +A G++H+L L+ D  ++AWG N  GQ+G G T  +  P RV G L N  +V IA
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIA 211

Query: 508 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
            G     A+   GEVY WG   +G+LG G+   +   P +V  L G  + +V+CG  H++
Sbjct: 212 CGQMCCMAVVDTGEVYVWGYNGNGQLGLGNS-GNQPTPCRVAALQGIRVQRVACGYAHTL 270

Query: 328 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPI 224
           VLT +G+++++            K    +P  V +
Sbjct: 271 VLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV 305



 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 51/203 (25%), Positives = 95/203 (46%), Gaps = 4/203 (1%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRS 560
           GD+++   P R+  L  ++++ ++ G+  ++ L+  +  ++ WG+N Y QLG G T    
Sbjct: 81  GDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGL 140

Query: 559 QPIRVE-GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
            P  +   LSN  ++++A G +HS  LT +GEV+AWG    G++G G   +  +      
Sbjct: 141 VPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTG 200

Query: 382 LLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKT 203
            L  + +V ++CG    + +   G ++ +                        N P P  
Sbjct: 201 CLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSG----------NQPTPCR 250

Query: 202 STSSEGLWQANYVACGGRHTLAI 134
             + +G+ +   VACG  HTL +
Sbjct: 251 VAALQGI-RVQRVACGYAHTLVL 272



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 55/200 (27%), Positives = 95/200 (47%), Gaps = 2/200 (1%)
 Frame = -2

Query: 724 IKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV 545
           I ++ +   +Q + Q  +        L  +V+  ++  G N  G LG+GD Q   +P R+
Sbjct: 33  IFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRL 92

Query: 544 EGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL-LAG 371
           + L+   +  ++ G G H    T EGEV+ WG   + +LG G      +VP  +   L+ 
Sbjct: 93  DSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHG-LVPCHISTNLSN 151

Query: 370 EDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSS 191
           + +++V+CG  HS+VLTSDG +F++            +V +G      +N P P+  T  
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAW------GYNNSGQVGSGS----TVNQPIPRRVTGC 201

Query: 190 EGLWQANYVACGGRHTLAIV 131
                   +ACG    +A+V
Sbjct: 202 LQNKVVVTIACGQMCCMAVV 221



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 51/149 (34%), Positives = 73/149 (48%), Gaps = 4/149 (2%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLEQ---VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 560
           G   N   P RV G  Q   V  IA G    +A+     ++ WG N  GQLG+G++  + 
Sbjct: 187 GSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQP 246

Query: 559 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 380
            P RV  L  + +  +A G  H+  LT EG+VYAWG   +G+LG G +KS+   P  V +
Sbjct: 247 TPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQSYPTPVTV 305

Query: 379 LAGEDIVQVSCGGTH-SVVLTSDGRIFSY 296
                I   +C  TH S   T  G ++ +
Sbjct: 306 EKDRIIEIAACHSTHTSAAKTQGGHVYMW 334



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 38/98 (38%), Positives = 54/98 (55%), Gaps = 4/98 (4%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
           G+  N  TP RV  L+  +V  +A G  H L L+ +  ++AWG N YGQLG G+   +S 
Sbjct: 240 GNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSY 299

Query: 556 PIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGR 449
           P  V  +    +++IAA      SAA T+ G VY WG+
Sbjct: 300 PTPVT-VEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336

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>RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like) (CHC1-L)
           (RCC1-like G exchanging factor)
          Length = 551

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 53/155 (34%), Positives = 83/155 (53%), Gaps = 1/155 (0%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIA 509
           +QV  +A G++H+L L+ D  ++AWG N  GQ+G G T  +  P RV G L N  +V IA
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIA 211

Query: 508 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
            G     A+   GEVY WG   +G+LG G+   +   P +V  L G  + +V+CG  H++
Sbjct: 212 CGQMCCMAVVDTGEVYVWGYNGNGQLGLGNS-GNQPTPCRVAALQGIRVQRVACGYAHTL 270

Query: 328 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPI 224
           VLT +G+++++            K    +P  V +
Sbjct: 271 VLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV 305



 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 51/203 (25%), Positives = 95/203 (46%), Gaps = 4/203 (1%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRS 560
           GD+++   P R+  L  ++++ ++ G+  ++ L+  +  ++ WG+N Y QLG G T    
Sbjct: 81  GDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGL 140

Query: 559 QPIRVE-GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
            P  +   LSN  ++++A G +HS  LT +GEV+AWG    G++G G   +  +      
Sbjct: 141 VPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTG 200

Query: 382 LLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKT 203
            L  + +V ++CG    + +   G ++ +                        N P P  
Sbjct: 201 CLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSG----------NQPTPCR 250

Query: 202 STSSEGLWQANYVACGGRHTLAI 134
             + +G+ +   VACG  HTL +
Sbjct: 251 VAALQGI-RVQRVACGYAHTLVL 272



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 55/200 (27%), Positives = 95/200 (47%), Gaps = 2/200 (1%)
 Frame = -2

Query: 724 IKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV 545
           I ++ +   +Q + Q  +        L  +V+  ++  G N  G LG+GD Q   +P R+
Sbjct: 33  IFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRL 92

Query: 544 EGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL-LAG 371
           + L+   +  ++ G G H    T EGEV+ WG   + +LG G      +VP  +   L+ 
Sbjct: 93  DSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHG-LVPCHISTNLSN 151

Query: 370 EDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSS 191
           + +++V+CG  HS+VLTSDG +F++            +V +G      +N P P+  T  
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAW------GYNNSGQVGSGS----TVNQPIPRRVTGC 201

Query: 190 EGLWQANYVACGGRHTLAIV 131
                   +ACG    +A+V
Sbjct: 202 LQNKVVVTIACGQMCCMAVV 221



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 51/149 (34%), Positives = 73/149 (48%), Gaps = 4/149 (2%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLEQ---VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 560
           G   N   P RV G  Q   V  IA G    +A+     ++ WG N  GQLG+G++  + 
Sbjct: 187 GSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQP 246

Query: 559 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 380
            P RV  L  + +  +A G  H+  LT EG+VYAWG   +G+LG G +KS+   P  V +
Sbjct: 247 TPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQSYPTPVTV 305

Query: 379 LAGEDIVQVSCGGTH-SVVLTSDGRIFSY 296
                I   +C  TH S   T  G ++ +
Sbjct: 306 EKDRIIEIAACHSTHTSAAKTQGGHVYMW 334



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 38/98 (38%), Positives = 54/98 (55%), Gaps = 4/98 (4%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
           G+  N  TP RV  L+  +V  +A G  H L L+ +  ++AWG N YGQLG G+   +S 
Sbjct: 240 GNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSY 299

Query: 556 PIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGR 449
           P  V  +    +++IAA      SAA T+ G VY WG+
Sbjct: 300 PTPVT-VEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQ 336

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>RCC2_BRARE (Q6NYE2) Protein RCC2 homolog|
          Length = 495

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 49/131 (37%), Positives = 77/131 (58%), Gaps = 2/131 (1%)
 Frame = -2

Query: 682 QVSMIAVG--AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 509
           QVS +  G  A H+L ++ +  LW+WG N+ GQLG GDT+    P  +EGL    +V  A
Sbjct: 122 QVSCVVSGPCAAHSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLGEEVIVAAA 181

Query: 508 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
            G  H+ ALT+ G VY +G  + G+LG G+   + + P  +Q   G+ IV+V+CG   S+
Sbjct: 182 CGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQ-YNGQPIVKVACGAEFSM 240

Query: 328 VLTSDGRIFSY 296
           ++   G ++S+
Sbjct: 241 IVDCKGNLYSF 251



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 49/171 (28%), Positives = 83/171 (48%), Gaps = 26/171 (15%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGD-TQPRS 560
           GD K +  P  ++GL  E +   A G  H LAL+ +  ++ +G N+ GQLG G+ T    
Sbjct: 158 GDTKRLEAPKLIEGLGEEVIVAAACGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVL 217

Query: 559 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK----------- 413
            P  ++  +   +V +A G   S  +  +G +Y++G  E+G+LG   D            
Sbjct: 218 SPATIQ-YNGQPIVKVACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEF 276

Query: 412 SSHMVPLQV----------QLLAGEDIV--QVSCGGTHSVVLTSDGRIFSY 296
              ++P +V          Q+L   ++V   V+CG  H++VL S  R+FS+
Sbjct: 277 DCELIPRRVAIFIEKTKDGQVLPVPNVVARDVACGANHTLVLDSQKRVFSW 327



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 45/154 (29%), Positives = 68/154 (44%), Gaps = 26/154 (16%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG-------IGDTQ---------PRSQP 554
           + +  +A GA  ++ +     L+++G  EYGQLG       I   Q         PR   
Sbjct: 227 QPIVKVACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVA 286

Query: 553 IRVEG--------LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 398
           I +E         + N+   D+A G  H+  L  +  V++WG G +GRLG  + K   MV
Sbjct: 287 IFIEKTKDGQVLPVPNVVARDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK-DEMV 345

Query: 397 PLQVQL--LAGEDIVQVSCGGTHSVVLTSDGRIF 302
           P  V+L    G    Q+ CG   S  L+  G +F
Sbjct: 346 PRLVKLFDFPGRGATQIYCGYQCSFALSEMGGLF 379

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>RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like|
           protein TD-60)
          Length = 522

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 45/121 (37%), Positives = 74/121 (61%)
 Frame = -2

Query: 658 AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALT 479
           A H+L ++ +  LW+WG NE GQLG GDT+    P  +EGLS+  +V  A G  H+ ALT
Sbjct: 159 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALT 218

Query: 478 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 299
           + G V+A+G  + G+LG G+   +   P Q+ +  G+ I +++CG   S+++   G ++S
Sbjct: 219 ETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKMACGAEFSMIMDCKGNLYS 277

Query: 298 Y 296
           +
Sbjct: 278 F 278



 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 52/173 (30%), Positives = 81/173 (46%), Gaps = 28/173 (16%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG---DTQP 566
           GD K +  P  ++GL  E +   A G  H LAL+    ++A+G N+ GQLG+G   D  P
Sbjct: 185 GDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVP 244

Query: 565 RSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDD---------- 416
               I   G     +  +A G   S  +  +G +Y++G  E+G+LG   D          
Sbjct: 245 SPAQIMYNG---QPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRI 301

Query: 415 -KSSHMVPLQV----------QLLAGEDIV--QVSCGGTHSVVLTSDGRIFSY 296
                +VP +V          Q+L   ++V   V+CG  H++VL S  R+FS+
Sbjct: 302 EYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSW 354



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 42/154 (27%), Positives = 69/154 (44%), Gaps = 26/154 (16%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG----------------DTQPRSQP 554
           + ++ +A GA  ++ +     L+++G  EYGQLG                  +  PR   
Sbjct: 254 QPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313

Query: 553 IRVEG--------LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 398
           I +E         + N+ + D+A G  H+  L  +  V++WG G +GRLG  + K   MV
Sbjct: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK-DEMV 372

Query: 397 PLQVQL--LAGEDIVQVSCGGTHSVVLTSDGRIF 302
           P  V+L    G    Q+  G T S  ++  G +F
Sbjct: 373 PRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLF 406

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>RCC2_XENLA (Q52KW8) Protein RCC2 homolog|
          Length = 513

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 49/131 (37%), Positives = 75/131 (57%), Gaps = 2/131 (1%)
 Frame = -2

Query: 682 QVSMIAVG--AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 509
           QV  +A G  A H+L ++V+  LW+WG N+ GQLG GD +    P  +E L     V  A
Sbjct: 140 QVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPKLIESLKGEVFVHAA 199

Query: 508 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
            G  H+ ALT+ G VYA+G  + G+LG G+   +   P Q+ L  G+ I +V+CG   S+
Sbjct: 200 CGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVPSPAQI-LYNGQPITKVACGAEFSM 258

Query: 328 VLTSDGRIFSY 296
           ++   G ++S+
Sbjct: 259 IMDCKGNLYSF 269



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 47/173 (27%), Positives = 78/173 (45%), Gaps = 28/173 (16%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLEQVSMI--AVGAFHNLALSVDRILWAWGNNEYGQLGIG---DTQP 566
           GDIK I  P  ++ L+    +  A G  H LAL+ +  ++A+G N+ GQLG+G   D  P
Sbjct: 176 GDIKRIDVPKLIESLKGEVFVHAACGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVP 235

Query: 565 RSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKS----SHMV 398
               I   G     +  +A G   S  +  +G +Y++G  E+G+LG   D      +  +
Sbjct: 236 SPAQILYNGQP---ITKVACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRI 292

Query: 397 PLQVQLLAGEDIV-------------------QVSCGGTHSVVLTSDGRIFSY 296
               +L+A    +                    ++CG  HS++L S  R+FS+
Sbjct: 293 EYDCELIARRIAIFIEKTKDGQILPVPNVVVRDIACGINHSLILDSQKRVFSW 345



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 43/154 (27%), Positives = 69/154 (44%), Gaps = 26/154 (16%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGI---GDTQPRSQPIRVE--------- 542
           + ++ +A GA  ++ +     L+++G  EYGQLG    G    R+Q I  +         
Sbjct: 245 QPITKVACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRIEYDCELIARRIA 304

Query: 541 ------------GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 398
                        + N+ + DIA G  HS  L  +  V++WG G +GRLG  + +   MV
Sbjct: 305 IFIEKTKDGQILPVPNVVVRDIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQR-DEMV 363

Query: 397 PLQVQL--LAGEDIVQVSCGGTHSVVLTSDGRIF 302
           P  V+L    G    Q+  G T S  ++  G +F
Sbjct: 364 PRLVKLFDFPGRGAAQIYAGATCSFAVSEMGGLF 397

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>RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1003

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 62/202 (30%), Positives = 100/202 (49%), Gaps = 3/202 (1%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
           G    +S P  V+ L  E+V   A G  H L  +    ++A G N  GQLG+GDT+ RS 
Sbjct: 70  GSKSTVSKPTCVKALKPEKVKFAACGRNHTLVSTEGGKVYAAGGNNEGQLGLGDTEERST 129

Query: 556 PIRVEGL-SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 380
              +    S   +  ++AG   SAALT++GE++ WG    G++G  ++ ++  VP QV +
Sbjct: 130 FHLISFFTSQRKIKQLSAGSNTSAALTEDGELFMWGDNSEGQIGL-ENVTNVCVPQQVTV 188

Query: 379 LAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTS 200
             G+ I  +SCG  HS  +T++G+++++            ++   H M  P+   P K  
Sbjct: 189 --GKPISWISCGYYHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGIPGKVV 246

Query: 199 TSSEGLWQANYVACGGRHTLAI 134
                      VACGG HT+ +
Sbjct: 247 ----------QVACGGGHTVVL 258



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 50/202 (24%), Positives = 95/202 (47%), Gaps = 2/202 (0%)
 Frame = -2

Query: 727 DIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ--PRSQP 554
           ++ N+  P +V   + +S I+ G +H+  ++ +  L+ +G  E G+LG+ +        P
Sbjct: 176 NVTNVCVPQQVTVGKPISWISCGYYHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMP 235

Query: 553 IRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLA 374
             V G+    +V +A GG H+  LT++  VY +G G+ G+LG G       VP  ++ + 
Sbjct: 236 QPVPGIPG-KVVQVACGGGHTVVLTEKA-VYTFGLGQFGQLGLGTFLFETSVPKAIEHIK 293

Query: 373 GEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTS 194
            + I  ++CG  H+ ++T  G ++++            + +T   +          T  S
Sbjct: 294 DQKISFIACGENHTALITDMGLMYTFGDGRHGKLGLGLENSTNQFI---------PTLCS 344

Query: 193 SEGLWQANYVACGGRHTLAIVT 128
           +   +    V+CGG HTL   T
Sbjct: 345 NFLRFIVQLVSCGGCHTLVFAT 366



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 46/183 (25%), Positives = 77/183 (42%)
 Frame = -2

Query: 676 SMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW 497
           + ++ G  H   ++ +  L+ +G+N +GQLG+G     S+P  V+ L    +   A G  
Sbjct: 38  TFLSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRN 97

Query: 496 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 317
           H+   T+ G+VYA G    G+LG GD +      L     +   I Q+S G   S  LT 
Sbjct: 98  HTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTE 157

Query: 316 DGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLA 137
           DG +F +                  P +V +  P              ++++CG  H+  
Sbjct: 158 DGELFMWGDNSEGQIGLENVTNVCVPQQVTVGKP-------------ISWISCGYYHSAF 204

Query: 136 IVT 128
           + T
Sbjct: 205 VTT 207

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>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8)
          Length = 698

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 48/127 (37%), Positives = 71/127 (55%)
 Frame = -2

Query: 679 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 500
           +  +A G      L+   I+  +G+   G LG G+    SQP  VE L    +V +A G 
Sbjct: 399 IKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGA 458

Query: 499 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 320
            H  AL+ +GE++AWGRG+ GRLG G  + SH  P QV +  G++  +V CG   S++LT
Sbjct: 459 SHVLALSTDGELFAWGRGDGGRLGLG-TRESHNCPQQVPVAPGQEAQRVVCGIDSSMILT 517

Query: 319 SDGRIFS 299
           S GR+ +
Sbjct: 518 SPGRVLA 524



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 41/123 (33%), Positives = 67/123 (54%), Gaps = 2/123 (1%)
 Frame = -2

Query: 709 TPVRVQGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGL 536
           TP+    L+Q  ++ V  G  H+ A++     + +G+N++GQLG    +    P RV+GL
Sbjct: 557 TPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGL 616

Query: 535 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQ 356
             + +V +A G   + A+  EGEVY+WG+G  GRLG  D+ +    P+Q+       +  
Sbjct: 617 EGIKMVMVACGDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAGLPRPVQLDETHPYMVTS 676

Query: 355 VSC 347
           VSC
Sbjct: 677 VSC 679



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 56/214 (26%), Positives = 86/214 (40%), Gaps = 15/214 (7%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            G++ +IS P  V+ L    M+ V  GA H LALS D  L+AWG  + G+LG+G  +  + 
Sbjct: 432  GNLTDISQPTIVEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNC 491

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGD-------------D 416
            P +V          +  G   S  LT  G V A G     +LG                +
Sbjct: 492  PQQVPVAPGQEAQRVVCGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVE 551

Query: 415  KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPM 236
            ++    PL    L  E ++ V  G  HS  +T+ G  +++            +  +  P 
Sbjct: 552  EALSFTPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPC 611

Query: 235  EVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 134
             V             EG+ +   VACG   T+A+
Sbjct: 612  RV----------QGLEGI-KMVMVACGDAFTVAV 634



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 47/175 (26%), Positives = 82/175 (46%), Gaps = 11/175 (6%)
 Frame = -2

Query: 715 ISTPVRVQGLE-QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGD----------TQ 569
           +S+P+R+  L  +V  +A G      ++    L  W   E   LG G            Q
Sbjct: 327 LSSPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILW---EAPPLGAGGGTLLPGAVELPQ 383

Query: 568 PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQ 389
           P+     +EG S +++  +A G   +A LT  G +  +G G +G LG G + +    P  
Sbjct: 384 PQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHG-NLTDISQPTI 442

Query: 388 VQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPI 224
           V+ L G ++VQV+CG +H + L++DG +F++            + +   P +VP+
Sbjct: 443 VEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPV 497



 Score = 37.7 bits (86), Expect = 0.037
 Identities = 44/159 (27%), Positives = 63/159 (39%), Gaps = 14/159 (8%)
 Frame = -2

Query: 562 SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
           S P+R+  L N  +V +AAG    A +T+ G +  W   E   LG G      ++P  V+
Sbjct: 328 SSPLRLPML-NTEVVQVAAGRTQKAGVTRSGRLILW---EAPPLGAG---GGTLLPGAVE 380

Query: 382 L------------LAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHP 239
           L             +G  I  V+CG   +  LT  G I ++                GH 
Sbjct: 381 LPQPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNG--------CLGHG 432

Query: 238 MEVPINLPPPKTSTSSEGL--WQANYVACGGRHTLAIVT 128
               I+ P     T  E L  ++   VACG  H LA+ T
Sbjct: 433 NLTDISQP-----TIVEALLGYEMVQVACGASHVLALST 466

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>RCC2_MOUSE (Q8BK67) Protein RCC2|
          Length = 520

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 44/121 (36%), Positives = 73/121 (60%)
 Frame = -2

Query: 658 AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALT 479
           A H+L ++ +  LW+WG NE GQLG GDT+    P  +E LS+ ++V  A G  H+ ALT
Sbjct: 157 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLALT 216

Query: 478 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 299
             G V+A+G  + G+LG G+   +   P Q+ +  G+ I +++CG   S+++   G ++S
Sbjct: 217 DTGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKMACGAEFSMLMDCKGNLYS 275

Query: 298 Y 296
           +
Sbjct: 276 F 276



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 51/173 (29%), Positives = 81/173 (46%), Gaps = 28/173 (16%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG---DTQP 566
           GD K +  P  ++ L  E + + A G  H LAL+    ++A+G N+ GQLG+G   D  P
Sbjct: 183 GDTKRVEAPRLIEALSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVP 242

Query: 565 RSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDD---------- 416
               I   G     +  +A G   S  +  +G +Y++G  E+G+LG   D          
Sbjct: 243 SPAQIMYNG---QPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRI 299

Query: 415 -KSSHMVPLQV----------QLLAGEDIV--QVSCGGTHSVVLTSDGRIFSY 296
                +VP +V          Q+L   ++V   V+CG  H++VL S  R+FS+
Sbjct: 300 EYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSW 352



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 42/154 (27%), Positives = 69/154 (44%), Gaps = 26/154 (16%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG----------------DTQPRSQP 554
           + ++ +A GA  ++ +     L+++G  EYGQLG                  +  PR   
Sbjct: 252 QPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 311

Query: 553 IRVEG--------LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 398
           I +E         + N+ + D+A G  H+  L  +  V++WG G +GRLG  + K   MV
Sbjct: 312 IFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK-DEMV 370

Query: 397 PLQVQL--LAGEDIVQVSCGGTHSVVLTSDGRIF 302
           P  V+L    G    Q+  G T S  ++  G +F
Sbjct: 371 PRLVKLFDFPGRGATQIYAGYTCSFAVSEVGGLF 404

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>RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1) (Chronic lymphocytic leukemia deletion region
           gene 7 protein) (CLL deletion region gene 7 protein)
          Length = 531

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 45/132 (34%), Positives = 78/132 (59%), Gaps = 1/132 (0%)
 Frame = -2

Query: 688 LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLS-LVDI 512
           ++QV  +A G+ H++AL+ D  ++AWG N  GQ+G G T  +  P +V    ++  +V I
Sbjct: 127 IKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGI 186

Query: 511 AAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHS 332
           A G   S A+   GEVY WG   +G+LG G++  + + P++V  L    + Q+ CG  H+
Sbjct: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNN-GNQLTPVRVAALHSVCVNQIVCGYAHT 245

Query: 331 VVLTSDGRIFSY 296
           + LT +G ++++
Sbjct: 246 LALTDEGLLYAW 257



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 45/149 (30%), Positives = 82/149 (55%), Gaps = 4/149 (2%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRS 560
           GD ++   P +++GL  +++  ++ G+  ++ LS  D +++AWG+N Y QLG G T    
Sbjct: 57  GDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGI 116

Query: 559 QPIRV-EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
            P++V   L    +V++A G  HS AL  +GEV+AWG    G++G G   +         
Sbjct: 117 APVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTN 176

Query: 382 LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
            L  + +V ++CG T S+ +  +G ++ +
Sbjct: 177 CLHIKRVVGIACGQTSSMAVLDNGEVYGW 205



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 47/150 (31%), Positives = 82/150 (54%), Gaps = 5/150 (3%)
 Frame = -2

Query: 730 GDIKNISTPVRVQG---LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 560
           G   N  TP +V     +++V  IA G   ++A+  +  ++ WG N  GQLG+G+   + 
Sbjct: 163 GSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQL 222

Query: 559 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 380
            P+RV  L ++ +  I  G  H+ ALT EG +YAWG   +G+LG G +K++ + P  + +
Sbjct: 223 TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG-NKNNLLSPAHI-M 280

Query: 379 LAGEDIVQV-SCGGTH-SVVLTSDGRIFSY 296
           +  E +V++ +C   H S   T  G ++ +
Sbjct: 281 VEKERVVEIAACHSAHTSAAKTQGGHVYMW 310



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 52/200 (26%), Positives = 95/200 (47%), Gaps = 2/200 (1%)
 Frame = -2

Query: 724 IKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV 545
           I  + +P  +  + +  +    A   L ++ +  ++ +G N    LG GD Q    P ++
Sbjct: 9   IFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKL 68

Query: 544 EGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQV-QLLAG 371
           EGL    +  ++ G G H    T++G VYAWG   + +LG G      + P+QV   L  
Sbjct: 69  EGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQG-IAPVQVCTNLLI 127

Query: 370 EDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSS 191
           + +V+V+CG  HS+ L +DG +F++            +V +G       N P P+  T+ 
Sbjct: 128 KQVVEVACGSHHSMALAADGEVFAW------GYNNCGQVGSGS----TANQPTPRKVTNC 177

Query: 190 EGLWQANYVACGGRHTLAIV 131
             + +   +ACG   ++A++
Sbjct: 178 LHIKRVVGIACGQTSSMAVL 197



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 40/98 (40%), Positives = 53/98 (54%), Gaps = 4/98 (4%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLEQV--SMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
           G+  N  TPVRV  L  V  + I  G  H LAL+ + +L+AWG N YGQLG G+      
Sbjct: 216 GNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLS 275

Query: 556 PIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGR 449
           P  +  +    +V+IAA      SAA T+ G VY WG+
Sbjct: 276 PAHIM-VEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312

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>GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 458

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 61/199 (30%), Positives = 91/199 (45%), Gaps = 14/199 (7%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYG---QLGIGDTQP----RSQPIRVEGLSNL 527
           E+V  IA G  H +A +   I++ WG        +L  G T P      +P RV GL N 
Sbjct: 153 EKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENS 212

Query: 526 SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVP--LQVQLLAGEDIVQV 353
             + + AG  HSA+LT  GEVY WG  +HG+L   ++ +   VP  ++      E +  +
Sbjct: 213 KAMCVLAGSDHSASLTDAGEVYVWGSNKHGQL--ANEAAFLPVPQKIEAHCFQNEKVTAI 270

Query: 352 SCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPME-----VPINLPPPKTSTSSE 188
             G TH V  T  G++F++            +   G  +E     +P + PP    +S  
Sbjct: 271 WSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPH 330

Query: 187 GLWQANYVACGGRHTLAIV 131
            L  A  V+CG  H LAI+
Sbjct: 331 CLTGATEVSCGSEHNLAII 349



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 2/110 (1%)
 Frame = -2

Query: 622 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSN-LSLVDIAAGGWHSAALTKEGEVYAWGRG 446
           L+AWG N YGQLG+G  +    P ++       S+  I  GG HSA +T  G+++  G  
Sbjct: 17  LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76

Query: 445 EHGRLGFGDDKS-SHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 299
           + G+LG G  +   +  P   + L G  I QV+CG   +++LT +G++ S
Sbjct: 77  KDGQLGLGHTEDIPYFTP--CKSLFGCPIQQVACGWDFTIMLTENGQVLS 124



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 35/128 (27%), Positives = 60/128 (46%)
 Frame = -2

Query: 679 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 500
           V  I  G  H+  ++    L+  G N+ GQLG+G T+        + L    +  +A G 
Sbjct: 51  VRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGW 110

Query: 499 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 320
             +  LT+ G+V + G    G+LG        +VP  ++ L  E +V ++ G  H+V  T
Sbjct: 111 DFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLRHAVAAT 169

Query: 319 SDGRIFSY 296
           + G +F +
Sbjct: 170 ASGIVFQW 177



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 39/139 (28%), Positives = 59/139 (42%), Gaps = 18/139 (12%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG------------------DTQPRS 560
           E+V+ I  G  H +A +    ++ WG  +YGQLG                       P S
Sbjct: 265 EKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNS 324

Query: 559 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 380
            P     L+  +  +++ G  H+ A+   G  Y+WG  EHG  G G + ++   P  VQ 
Sbjct: 325 MPSSPHCLTGAT--EVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTE-ANVWAPKPVQA 380

Query: 379 LAGEDIVQVSCGGTHSVVL 323
           L     + V CG  HS+ L
Sbjct: 381 LLSSSGLLVGCGAGHSLAL 399



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 37/132 (28%), Positives = 55/132 (41%), Gaps = 6/132 (4%)
 Frame = -2

Query: 679 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 500
           +  +A G    + L+ +  + + G+N +GQLG+     R    +   L    +V IAAG 
Sbjct: 103 IQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGL 162

Query: 499 WHSAALTKEGEVYAWGRGEHG---RLGFGDDKSSHMV---PLQVQLLAGEDIVQVSCGGT 338
            H+ A T  G V+ WG G      RL  G           P +V  L     + V  G  
Sbjct: 163 RHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSD 222

Query: 337 HSVVLTSDGRIF 302
           HS  LT  G ++
Sbjct: 223 HSASLTDAGEVY 234



 Score = 37.7 bits (86), Expect = 0.037
 Identities = 26/77 (33%), Positives = 40/77 (51%)
 Frame = -2

Query: 712 STPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLS 533
           S+P  + G  +VS    G+ HNLA+ +  + ++WG NE+G  G G       P  V+ L 
Sbjct: 327 SSPHCLTGATEVSC---GSEHNLAI-IGGVCYSWGWNEHGMCGDGTEANVWAPKPVQALL 382

Query: 532 NLSLVDIAAGGWHSAAL 482
           + S + +  G  HS AL
Sbjct: 383 SSSGLLVGCGAGHSLAL 399



 Score = 36.6 bits (83), Expect = 0.082
 Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 1/65 (1%)
 Frame = -2

Query: 493 SAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQV-QLLAGEDIVQVSCGGTHSVVLTS 317
           S A      ++AWG   +G+LG G  K   ++P Q+        + +++ GG HS V+T 
Sbjct: 8   SEAAPAAAALFAWGANSYGQLGLG-HKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTD 66

Query: 316 DGRIF 302
            G +F
Sbjct: 67  GGDLF 71

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>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8) (NIMA-related kinase 12a)
          Length = 692

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 47/124 (37%), Positives = 67/124 (54%)
 Frame = -2

Query: 679 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 500
           +  +A G F    L+   I+  +G+   G LG G     SQP  VE L    +V +A G 
Sbjct: 393 IKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGA 452

Query: 499 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 320
            H  AL+ E E++AWGRG+ GRLG G  + SH  P QV +  G++  +V CG   S++LT
Sbjct: 453 SHVLALSTERELFAWGRGDSGRLGLG-TRESHSCPQQVPMPPGQEAQRVVCGIDSSMILT 511

Query: 319 SDGR 308
             G+
Sbjct: 512 VPGQ 515



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 35/113 (30%), Positives = 60/113 (53%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 506
           E +  I +G  H+ A++     + +G+N++GQLG    +    P +V+GL  + +  +A 
Sbjct: 561 EPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVAC 620

Query: 505 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 347
           G   + A+  E EVY+WG+G  GRLG  D+ +    P+Q+       +  VSC
Sbjct: 621 GDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSC 673



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 59/214 (27%), Positives = 88/214 (41%), Gaps = 15/214 (7%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            G + +IS P  V+ L    M+ V  GA H LALS +R L+AWG  + G+LG+G  +  S 
Sbjct: 426  GSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSC 485

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLG-----FGDDKSSHM--- 401
            P +V          +  G   S  LT  G+  A G     +LG      G++   H    
Sbjct: 486  PQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVE 545

Query: 400  VPLQVQLLAG-----EDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPM 236
              L   LL       E ++ +  G  HS  +T+ G  +++            +  +  P 
Sbjct: 546  EALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPC 605

Query: 235  EVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 134
            +V             EG+  A  VACG   T+AI
Sbjct: 606  KV----------QGLEGIKMA-MVACGDAFTVAI 628



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 53/198 (26%), Positives = 90/198 (45%), Gaps = 11/198 (5%)
 Frame = -2

Query: 715 ISTPVRVQGLE-QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGD--------TQPR 563
           + TP+R+  L  +V  +A G      ++    L  W   E   LG G          QP+
Sbjct: 321 LGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILW---EAPPLGAGGGSLLPGAVEQPQ 377

Query: 562 SQPIR--VEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQ 389
            Q I   +EG S +++  +A G + +A LT  G +  +G G +G LG G   +    P  
Sbjct: 378 PQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHG-SLTDISQPTI 436

Query: 388 VQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPP 209
           V+ L G ++VQV+CG +H + L+++  +F++            + +   P +VP  +PP 
Sbjct: 437 VEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVP--MPPG 494

Query: 208 KTSTSSEGLWQANYVACG 155
           +         +A  V CG
Sbjct: 495 Q---------EAQRVVCG 503



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 45/173 (26%), Positives = 68/173 (39%), Gaps = 8/173 (4%)
 Frame = -2

Query: 622 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAW---- 455
           ++AWG       G+G       P+R+  L N  +V +AAG    A +T+ G +  W    
Sbjct: 314 VYAWGG------GLGT------PLRLPML-NTEVVQVAAGRTQKAGVTRSGRLILWEAPP 360

Query: 454 -GRGEHGRL-GFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXX 281
            G G    L G  +      +   ++  +G  I  V+CG   +  LT  G I ++     
Sbjct: 361 LGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSN 420

Query: 280 XXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGL--WQANYVACGGRHTLAIVT 128
                      GH     I+ P     T  E L  ++   VACG  H LA+ T
Sbjct: 421 G--------CLGHGSLTDISQP-----TIVEALLGYEMVQVACGASHVLALST 460

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>RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1020

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 60/202 (29%), Positives = 96/202 (47%), Gaps = 3/202 (1%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
           G    IS P  V+ L  E+V + A G  H L  +    ++A G N  GQLG+GDT+ R+ 
Sbjct: 70  GSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNT 129

Query: 556 PIRVEGL-SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 380
              +    S   +  ++AG   SAALT++G ++ WG    G++G   + S+  VP QV +
Sbjct: 130 FHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTI 188

Query: 379 LAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTS 200
             G+ +  +SCG  HS  +T+DG ++ +            ++   H     ++  P K  
Sbjct: 189 --GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI 246

Query: 199 TSSEGLWQANYVACGGRHTLAI 134
                      VACGG HT+ +
Sbjct: 247 ----------QVACGGEHTVVL 258



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 47/181 (25%), Positives = 78/181 (43%)
 Frame = -2

Query: 670 IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 491
           ++ G  H+  ++ +  L+ +G+N +GQLG+G     S+P  V+ L    +   A G  H+
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99

Query: 490 AALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDG 311
              T+ G VYA G    G+LG GD +  +   +     +   I Q+S G   S  LT DG
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159

Query: 310 RIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 131
           R+F +                  P +V I  P              ++++CG  H+  + 
Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP-------------VSWISCGYYHSAFVT 206

Query: 130 T 128
           T
Sbjct: 207 T 207



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 43/140 (30%), Positives = 75/140 (53%), Gaps = 3/140 (2%)
 Frame = -2

Query: 718 NISTPVRVQGL-EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ-PRSQPIRV 545
           N  TP  V  + E+V  +A G  H + L+ +  ++ +G  ++GQLG+G      S+P  +
Sbjct: 231 NHRTPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVI 289

Query: 544 EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFG-DDKSSHMVPLQVQLLAGE 368
           E + + ++  I+ G  H+A +T  G +Y +G G HG+LG G ++ ++H +P         
Sbjct: 290 ENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRF 349

Query: 367 DIVQVSCGGTHSVVLTSDGR 308
            +  V+CGG H VV  +  R
Sbjct: 350 IVKLVACGGCHMVVFAAPHR 369



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 50/196 (25%), Positives = 90/196 (45%), Gaps = 2/196 (1%)
 Frame = -2

Query: 727 DIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ--P 554
           ++ N+  P +V   + VS I+ G +H+  ++ D  L+ +G  E G+LG+ +    +   P
Sbjct: 176 NVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTP 235

Query: 553 IRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLA 374
             V  +    ++ +A GG H+  LT E  VY +G G+ G+LG G        P  ++ + 
Sbjct: 236 QLVSEIPE-KVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293

Query: 373 GEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTS 194
            + I  +SCG  H+ ++T  G ++++            +  T H +          T  S
Sbjct: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFI---------PTLCS 344

Query: 193 SEGLWQANYVACGGRH 146
           +   +    VACGG H
Sbjct: 345 NFLRFIVKLVACGGCH 360



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 24/74 (32%), Positives = 40/74 (54%)
 Frame = -2

Query: 520 VDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG 341
           V ++ G  HSA +T   ++Y +G    G+LG G  KS+   P  V+ L  E +   +CG 
Sbjct: 38  VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG-SKSAISKPTCVKALKPEKVKLAACGR 96

Query: 340 THSVVLTSDGRIFS 299
            H++V T  G +++
Sbjct: 97  NHTLVSTEGGNVYA 110

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>RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulator (mRpgr)|
          Length = 1001

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 58/186 (31%), Positives = 95/186 (51%), Gaps = 2/186 (1%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV-DIA 509
           E+V + A G  H L  +    ++A G N  GQLG+GDT  R    ++   +    +  ++
Sbjct: 87  EKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLS 146

Query: 508 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 329
           AG   SAALT++G+++ WG    G++G  +DKS+  +P +V +  G+ I  +SCG  HS 
Sbjct: 147 AGANTSAALTEDGKLFMWGDNSEGQIGL-EDKSNVCIPHEVTV--GKPISWISCGYYHSA 203

Query: 328 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPIN-LPPPKTSTSSEGLWQANYVACGG 152
            +T DG ++++                G P E+ +N   P +     E + Q   VACGG
Sbjct: 204 FVTMDGELYTFGEPENG--------KLGLPNELLMNHRSPQRVLGIPERVIQ---VACGG 252

Query: 151 RHTLAI 134
            HT+ +
Sbjct: 253 GHTVVL 258



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 57/202 (28%), Positives = 94/202 (46%), Gaps = 2/202 (0%)
 Frame = -2

Query: 727 DIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDT--QPRSQP 554
           D  N+  P  V   + +S I+ G +H+  +++D  L+ +G  E G+LG+ +        P
Sbjct: 176 DKSNVCIPHEVTVGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSP 235

Query: 553 IRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLA 374
            RV G+    ++ +A GG H+  LT E  VYA+G G+ G+LG G        P  ++ + 
Sbjct: 236 QRVLGIPE-RVIQVACGGGHTVVLT-EKVVYAFGLGQFGQLGLGTFLFETSEPKIIERIK 293

Query: 373 GEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTS 194
            + I  +SCG  H+ ++T  G ++++                G  ME   N   P T  S
Sbjct: 294 DQKICHISCGENHTALMTELGLLYTFGDGRHG--------KLGLGMENFTNQFFP-TLCS 344

Query: 193 SEGLWQANYVACGGRHTLAIVT 128
           +   +    +ACGG H L   T
Sbjct: 345 NFLRFAVQLIACGGCHMLVFAT 366



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 47/173 (27%), Positives = 72/173 (41%)
 Frame = -2

Query: 670 IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 491
           ++ G  H   ++ +  L+ +G+N +GQLG+G      +P  ++ L    +   A G  H+
Sbjct: 40  LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHT 99

Query: 490 AALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDG 311
              T  G VYA G    G+LG GD          V     + I Q+S G   S  LT DG
Sbjct: 100 LVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDG 159

Query: 310 RIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGG 152
           ++F +            K     P EV +  P    S  S G + + +V   G
Sbjct: 160 KLFMWGDNSEGQIGLEDKSNVCIPHEVTVGKP---ISWISCGYYHSAFVTMDG 209

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>RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1)
          Length = 531

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 52/203 (25%), Positives = 94/203 (46%), Gaps = 4/203 (1%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGL--EQVSMIAVGAF-HNLALSVDRILWAWGNNEYGQLGIGDTQPRS 560
           GD ++   P +++ L  +++  ++ G+  H L  + D +++AWG+N Y QLG G T    
Sbjct: 57  GDNQSTLVPKKLEALCGKKIKSLSYGSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGI 116

Query: 559 QPIRV-EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
            P++V   L    ++++A G  HS AL  +GE++AWG    G++G G   +         
Sbjct: 117 APVQVCTNLLIKQVIEVACGSHHSMALAADGELFAWGYNNCGQVGSGSTANQPTPRKVTN 176

Query: 382 LLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKT 203
            L  + +V ++CG T S+ +   G ++ +                  P+ V         
Sbjct: 177 CLHTKRVVNIACGQTSSMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRV--------- 227

Query: 202 STSSEGLWQANYVACGGRHTLAI 134
             +  G+   N + CG  HTLA+
Sbjct: 228 -AALHGMC-VNQIVCGYAHTLAL 248



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 48/149 (32%), Positives = 75/149 (50%), Gaps = 4/149 (2%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGL---EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS 560
           G   N  TP +V      ++V  IA G   ++A+     ++ WG N  GQLG+G+   + 
Sbjct: 163 GSTANQPTPRKVTNCLHTKRVVNIACGQTSSMAVLDSGEVYGWGYNGNGQLGLGNNGNQL 222

Query: 559 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 380
            P+RV  L  + +  I  G  H+ ALT EG +YAWG   +G+LG G  K++ + P Q+ +
Sbjct: 223 TPVRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG-SKNNLLSPTQIMV 281

Query: 379 LAGEDIVQVSCGGTH-SVVLTSDGRIFSY 296
                I   +C  TH S   T  G ++ +
Sbjct: 282 EKERVIEIAACHSTHTSAAKTQGGHVYMW 310



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 39/98 (39%), Positives = 53/98 (54%), Gaps = 4/98 (4%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLEQ--VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
           G+  N  TPVRV  L    V+ I  G  H LAL+ + +L+AWG N YGQLG G       
Sbjct: 216 GNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGSKNNLLS 275

Query: 556 PIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGR 449
           P ++  +    +++IAA      SAA T+ G VY WG+
Sbjct: 276 PTQIM-VEKERVIEIAACHSTHTSAAKTQGGHVYMWGQ 312



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 32/118 (27%), Positives = 56/118 (47%), Gaps = 1/118 (0%)
 Frame = -2

Query: 484 LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCG-GTHSVVLTSDGR 308
           +T   EV+ +G      LG GD++S+ +VP +++ L G+ I  +S G G H ++ T DG 
Sbjct: 37  VTDNDEVFVFGLNYSNCLGTGDNQST-LVPKKLEALCGKKIKSLSYGSGPHVLLTTEDGV 95

Query: 307 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 134
           ++++                  P++V  NL           + Q   VACG  H++A+
Sbjct: 96  VYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL----------IKQVIEVACGSHHSMAL 143

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>RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regulator homolog|
          Length = 1392

 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 47/123 (38%), Positives = 72/123 (58%), Gaps = 1/123 (0%)
 Frame = -2

Query: 670  IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 491
            IA GA H L LS    L AWG N +GQ G+G +   +   +V+G    ++  IA G +HS
Sbjct: 781  IACGAEHILVLSSSGQLSAWGGNRFGQCGVGHSFRIANLHQVDG-DWPAIEKIACGQFHS 839

Query: 490  AALTKEGEVYAWGRGEHGRLGFGD-DKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSD 314
            A +  +G ++ +G G  G+LG G  + S+ +VP +V  L  + + Q++CG  H+VVLT  
Sbjct: 840  AFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLICK-VTQIACGRAHTVVLTDT 898

Query: 313  GRI 305
            GR+
Sbjct: 899  GRV 901



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 46/132 (34%), Positives = 63/132 (47%), Gaps = 4/132 (3%)
 Frame = -2

Query: 679  VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ--PIRVEGLSNLSLVDIAA 506
            +  IA G FH+  +  D  LW +G   +GQLG G     +Q  P RV GL    +  IA 
Sbjct: 829  IEKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLI-CKVTQIAC 887

Query: 505  GGWHSAALTKEGEVYAWGRGEHGRLGFGDD--KSSHMVPLQVQLLAGEDIVQVSCGGTHS 332
            G  H+  LT  G V   G G +G++G  DD  K     PL +  L   DI   +    HS
Sbjct: 888  GRAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDI---ATHYYHS 944

Query: 331  VVLTSDGRIFSY 296
            + +T D R+F +
Sbjct: 945  ICITEDNRVFEW 956



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 31/77 (40%), Positives = 45/77 (58%)
 Frame = -2

Query: 526  SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 347
            ++V +A G  HSA +T EG +Y WG+G   +LG G +K+  M P QV    G   V VS 
Sbjct: 1023 NIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHG-NKNERMEPHQVFEPNGAKWVNVSL 1081

Query: 346  GGTHSVVLTSDGRIFSY 296
            G  H++  T DG +F++
Sbjct: 1082 GNNHTIASTDDGSVFAW 1098



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 46/179 (25%), Positives = 76/179 (42%), Gaps = 38/179 (21%)
 Frame = -2

Query: 718  NISTPVRVQGLE-QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVE 542
            N   P RV GL  +V+ IA G  H + L+    +   G+  YGQ+G+ D   +       
Sbjct: 868  NQLVPTRVNGLICKVTQIACGRAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPL 927

Query: 541  GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRG--------------EHGRLGFGDDKSSH 404
             L  L + DIA   +HS  +T++  V+ WGR                  +L   +D SS 
Sbjct: 928  PLGPLRVRDIATHYYHSICITEDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSP 987

Query: 403  M-----------------VP------LQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
                              +P       +V+     +IV V+CG +HS ++TS+G ++++
Sbjct: 988  SPSTNGSTPRVNLNLPAEIPREDLGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTW 1046



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 25/81 (30%), Positives = 44/81 (54%)
 Frame = -2

Query: 670  IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 491
            +A G  H+  ++ +  L+ WG     QLG G+   R +P +V   +    V+++ G  H+
Sbjct: 1027 VACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGAKWVNVSLGNNHT 1086

Query: 490  AALTKEGEVYAWGRGEHGRLG 428
             A T +G V+AWG+ + G+ G
Sbjct: 1087 IASTDDGSVFAWGKNDFGQCG 1107



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 11/30 (36%), Positives = 21/30 (70%)
 Frame = -2

Query: 670  IAVGAFHNLALSVDRILWAWGNNEYGQLGI 581
            +++G  H +A + D  ++AWG N++GQ G+
Sbjct: 1079 VSLGNNHTIASTDDGSVFAWGKNDFGQCGV 1108

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>ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1657

 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 37/100 (37%), Positives = 58/100 (58%)
 Frame = -2

Query: 622 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 443
           +W WG  + GQLG GD  PR QP+ V+ L    ++ + AGG+HS ALT + +VY+WG   
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587

Query: 442 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 323
            G+LG  D  ++  VP   ++ +   +  V+ G  +S+ L
Sbjct: 588 FGQLGHSDFPTT--VPRLAKISSENGVWSVAAGRDYSLFL 625



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 36/122 (29%), Positives = 61/122 (50%)
 Frame = -2

Query: 469 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXX 290
           EV+ WG+G+ G+LG GD     + PL V+ L G++++ +  GG HS+ LT+  +++S+  
Sbjct: 527 EVWTWGKGKEGQLGHGD-VLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGS 585

Query: 289 XXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVTWTDM*L 110
                         GH  + P  +P     +S  G+W    VA G  ++L +V   D   
Sbjct: 586 NTFG--------QLGH-SDFPTTVPRLAKISSENGVWS---VAAGRDYSLFLVDTEDFQP 633

Query: 109 GI 104
           G+
Sbjct: 634 GL 635



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 50/201 (24%), Positives = 86/201 (42%), Gaps = 8/201 (3%)
 Frame = -2

Query: 709 TPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGL 536
           TP R+ G   + V   A+G  H + L+ D  ++++G   + + G  +  P S PI    L
Sbjct: 31  TPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICP-SSPILENAL 88

Query: 535 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK------SSHMVPLQVQLLA 374
               +V +A G +HS A+T  G  Y WG    G+    + +         +   +   L 
Sbjct: 89  VGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLL 148

Query: 373 GEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTS 194
              I+Q++CG  H++ L+    I+++             +TT      P+  P      +
Sbjct: 149 AVRILQLACGEEHTLALSISREIWAWGTGCQLGL-----ITTA----FPVTKPQKVEHLA 199

Query: 193 SEGLWQANYVACGGRHTLAIV 131
              + Q   VACG  H+LA+V
Sbjct: 200 GRVVLQ---VACGAFHSLALV 217



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
           GD+     P+ V+ L+  +V  +  G +H+LAL+    +++WG+N +GQLG  D  P + 
Sbjct: 542 GDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF-PTTV 600

Query: 556 PIRVEGLSNLSLVDIAAGGWHSAAL 482
           P   +  S   +  +AAG  +S  L
Sbjct: 601 PRLAKISSENGVWSVAAGRDYSLFL 625



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 17/61 (27%), Positives = 29/61 (47%)
 Frame = -2

Query: 478 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 299
           K     A G  E G +      S  + P ++    G+ ++Q + G  H V+LT DG ++S
Sbjct: 5   KRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64

Query: 298 Y 296
           +
Sbjct: 65  F 65

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>RCC1_CANAL (P52499) Protein RCC1|
          Length = 464

 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 48/149 (32%), Positives = 75/149 (50%), Gaps = 17/149 (11%)
 Frame = -2

Query: 691 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGI----GDTQPRS---QPIRVEGLS 533
           GL  +  IA G FH  A+     ++AWG N+YGQ  +    G+ +  S   +P  +  LS
Sbjct: 249 GLYNIKYIASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELS 308

Query: 532 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK----------SSHMVPLQVQ 383
           +  + +IAAG  H+ ALT++G+VYAWGR +   +G   DK           +H     +Q
Sbjct: 309 HKGIKEIAAGEHHTLALTEDGQVYAWGRYDMKEIGIPKDKLPKSTFKINTGTHGSFSFLQ 368

Query: 382 LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
            L    I  +  G  HS  +T DG ++++
Sbjct: 369 NLFAVKIKTIGVGSHHSFAVTEDGVVYAW 397



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 38/130 (29%), Positives = 58/130 (44%), Gaps = 13/130 (10%)
 Frame = -2

Query: 679 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV-----------EGLS 533
           +  IA G  H LAL+ D  ++AWG  +  ++GI   +      ++           + L 
Sbjct: 312 IKEIAAGEHHTLALTEDGQVYAWGRYDMKEIGIPKDKLPKSTFKINTGTHGSFSFLQNLF 371

Query: 532 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLA--GEDIV 359
            + +  I  G  HS A+T++G VYAWG  E    G G        P ++   A   EDI+
Sbjct: 372 AVKIKTIGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSIDDVEKPTRIVNTATKNEDIL 431

Query: 358 QVSCGGTHSV 329
            +  GG  SV
Sbjct: 432 LIGAGGQFSV 441



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 40/127 (31%), Positives = 52/127 (40%), Gaps = 30/127 (23%)
 Frame = -2

Query: 667 AVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR------------------------- 563
           AVG  H LAL     +W+WG N+   LG    Q +                         
Sbjct: 71  AVGGMHTLALDGKNRIWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDDDDDDEDGDLNE 130

Query: 562 --SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWG--RGEHGRLGF-GDDKSSHMV 398
             S P  VE L    +V +AA    SAAL   G+VY+WG  R   G LGF  D+      
Sbjct: 131 AESTPALVENLPEGEIVQLAATDNLSAALLSNGDVYSWGCFRCNEGLLGFLRDEIKLQKT 190

Query: 397 PLQVQLL 377
           PL+++ L
Sbjct: 191 PLKIKEL 197



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 35/143 (24%), Positives = 58/143 (40%), Gaps = 34/143 (23%)
 Frame = -2

Query: 622 LWAWGNNEYGQLGIGDT-------QPRSQP-IRVEGLSNLSLVDIAAGGWHSAALTKEGE 467
           ++ WG     +LG+G +       +PR  P +  E L    +VD A GG H+ AL  +  
Sbjct: 26  VFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLGGTKIVDFAVGGMHTLALDGKNR 85

Query: 466 VYAWGRGEHGRLG--------------------------FGDDKSSHMVPLQVQLLAGED 365
           +++WG  +   LG                           GD   +   P  V+ L   +
Sbjct: 86  IWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDDDDDDEDGDLNEAESTPALVENLPEGE 145

Query: 364 IVQVSCGGTHSVVLTSDGRIFSY 296
           IVQ++     S  L S+G ++S+
Sbjct: 146 IVQLAATDNLSAALLSNGDVYSW 168



 Score = 34.7 bits (78), Expect = 0.31
 Identities = 20/65 (30%), Positives = 29/65 (44%), Gaps = 7/65 (10%)
 Frame = -2

Query: 469 EVYAWGRGEHGRLGFGDDKSSHMVP-------LQVQLLAGEDIVQVSCGGTHSVVLTSDG 311
           +V+ WG G    LG G    +  V        L  + L G  IV  + GG H++ L    
Sbjct: 25  DVFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLGGTKIVDFAVGGMHTLALDGKN 84

Query: 310 RIFSY 296
           RI+S+
Sbjct: 85  RIWSW 89



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
 Frame = -2

Query: 682 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDT-QPRSQPIRV--EGLSNLSLVDI 512
           ++  I VG+ H+ A++ D +++AWG  E    G+G +     +P R+      N  ++ I
Sbjct: 374 KIKTIGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSIDDVEKPTRIVNTATKNEDILLI 433

Query: 511 AAGGWHSAA 485
            AGG  S +
Sbjct: 434 GAGGQFSVS 442

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>ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)|
          Length = 1657

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 36/100 (36%), Positives = 58/100 (58%)
 Frame = -2

Query: 622 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 443
           +W WG  + GQLG GD  PR QP+ V+ L    ++ + AGG+HS ALT + +VY+WG   
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587

Query: 442 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 323
            G+LG  D  ++  VP   ++ +   +  ++ G  +S+ L
Sbjct: 588 FGQLGHSDFPTT--VPRLAKISSENGVWSIAAGRDYSLFL 625



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 35/122 (28%), Positives = 61/122 (50%)
 Frame = -2

Query: 469 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXX 290
           EV+ WG+G+ G+LG GD     + PL V+ L G++++ +  GG HS+ LT+  +++S+  
Sbjct: 527 EVWTWGKGKEGQLGHGD-VLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGS 585

Query: 289 XXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVTWTDM*L 110
                         GH  + P  +P     +S  G+W    +A G  ++L +V   D   
Sbjct: 586 NTFG--------QLGH-SDFPTTVPRLAKISSENGVWS---IAAGRDYSLFLVDTEDFQP 633

Query: 109 GI 104
           G+
Sbjct: 634 GL 635



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 49/201 (24%), Positives = 86/201 (42%), Gaps = 8/201 (3%)
 Frame = -2

Query: 709 TPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGL 536
           TP R+ G   + V   A+G  H + L+ D  ++++G   + + G  +  P S PI    L
Sbjct: 31  TPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICP-SSPILENAL 88

Query: 535 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK------SSHMVPLQVQLLA 374
               ++ +A G +HS A+T  G  Y WG    G+    + +         +   +   L 
Sbjct: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLL 148

Query: 373 GEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTS 194
              I+Q++CG  H++ L+    I+++             +TT      P+  P      +
Sbjct: 149 AVRILQLACGEEHTLALSISREIWAWGTGCQLGL-----ITTA----FPVTKPQKVEHLA 199

Query: 193 SEGLWQANYVACGGRHTLAIV 131
              + Q   VACG  H+LA+V
Sbjct: 200 GRVVLQ---VACGAFHSLALV 217



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
           GD+     P+ V+ L+  +V  +  G +H+LAL+    +++WG+N +GQLG  D  P + 
Sbjct: 542 GDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF-PTTV 600

Query: 556 PIRVEGLSNLSLVDIAAGGWHSAAL 482
           P   +  S   +  IAAG  +S  L
Sbjct: 601 PRLAKISSENGVWSIAAGRDYSLFL 625



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 17/61 (27%), Positives = 29/61 (47%)
 Frame = -2

Query: 478 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 299
           K     A G  E G +      S  + P ++    G+ ++Q + G  H V+LT DG ++S
Sbjct: 5   KRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64

Query: 298 Y 296
           +
Sbjct: 65  F 65

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>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)|
           (NimA-related protein kinase 8)
          Length = 697

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 42/127 (33%), Positives = 68/127 (53%)
 Frame = -2

Query: 679 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 500
           +  ++ G      L+   I+  +G+   G LG G+    +QP  VE L    LV ++ G 
Sbjct: 400 IKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGA 459

Query: 499 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 320
            H  A+T E EV++WGRG++GRLG    + SH  P QV L A  +  +V CG   S++++
Sbjct: 460 SHVLAVTNEREVFSWGRGDNGRLGLA-TQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMS 518

Query: 319 SDGRIFS 299
           +  +I +
Sbjct: 519 TQHQILA 525



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 34/113 (30%), Positives = 60/113 (53%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 506
           E++  I +G  H++A++     + +G+N++GQLG    +    P +V GL  +++   A 
Sbjct: 568 EKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQGITMA--AC 625

Query: 505 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 347
           G   + A+  EGEVY WG+G  GRLG  ++      P+Q+       +  V+C
Sbjct: 626 GDAFTLAIGAEGEVYTWGKGARGRLGRKEEDFGIPKPVQLDESHAFTVTSVAC 678



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 42/147 (28%), Positives = 75/147 (51%), Gaps = 7/147 (4%)
 Frame = -2

Query: 715 ISTPVRVQGLE-QVSMIAVGAFHNLALSVDRILWAW-----GNNEYGQLG-IGDTQPRSQ 557
           ISTP+R+  L  +V  +++G    + ++    L  W     G+ E    G +   QP+  
Sbjct: 329 ISTPLRLPMLNTEVIQVSLGRTQKMGVTKSGRLITWEAPSVGSGEPTLPGAVEQMQPQFI 388

Query: 556 PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 377
              +EG S +++  ++ G   +  LT  G +  +G G +G LG G+       P  V+ L
Sbjct: 389 SRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQ-PKIVEAL 447

Query: 376 AGEDIVQVSCGGTHSVVLTSDGRIFSY 296
            G ++VQVSCG +H + +T++  +FS+
Sbjct: 448 LGYELVQVSCGASHVLAVTNEREVFSW 474



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 51/214 (23%), Positives = 90/214 (42%), Gaps = 15/214 (7%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
            G+  +++ P  V+ L    ++ V  GA H LA++ +R +++WG  + G+LG+      + 
Sbjct: 433  GNFNDVTQPKIVEALLGYELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLATQDSHNC 492

Query: 556  PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGF----GDDKSS------ 407
            P +V   ++     +  G   S  ++ + ++ A G     +LG     G ++ S      
Sbjct: 493  PQQVSLPADFEAQRVLCGVDCSMIMSTQHQILACGNNRFNKLGLDKVSGTEEPSSFCQVE 552

Query: 406  --HMVPL-QVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPM 236
              H+  L Q   L  E IV +  G  HSV +T  G+ F++            + ++  P 
Sbjct: 553  EVHLFQLVQSAPLNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPY 612

Query: 235  EVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 134
            +V              GL      ACG   TLAI
Sbjct: 613  QV-------------SGLQGITMAACGDAFTLAI 633



 Score = 33.1 bits (74), Expect = 0.91
 Identities = 14/41 (34%), Positives = 23/41 (56%)
 Frame = -2

Query: 706 PVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG 584
           P +V GL+ ++M A G    LA+  +  ++ WG    G+LG
Sbjct: 611 PYQVSGLQGITMAACGDAFTLAIGAEGEVYTWGKGARGRLG 651

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>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase)
          Length = 944

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 6/131 (4%)
 Frame = -2

Query: 670 IAVGAFHNLALSVDRILWAW-----GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 506
           +  G  H   ++V++ L+ W     G+  +GQLG GD     QP  VE L   S+  ++ 
Sbjct: 356 VCAGDAHFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQKVSC 415

Query: 505 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV-PLQVQLLAGEDIVQVSCGGTHSV 329
           G   +  +T EG++Y++G   +G LG      S ++ PL V     E + QVSCG +H +
Sbjct: 416 GSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSCGDSHIM 475

Query: 328 VLTSDGRIFSY 296
            LT    ++S+
Sbjct: 476 ALTRSKSVYSW 486



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 44/148 (29%), Positives = 78/148 (52%), Gaps = 4/148 (2%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS- 560
           GD  +   P  V+ L+   V  ++ G+   + ++ +  L+++G++ YG LG+  +     
Sbjct: 391 GDRASYRQPKHVEKLQGKSVQKVSCGSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEV 450

Query: 559 -QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
            +P+ V+   N  +  ++ G  H  ALT+   VY+WG GE+GRLG  D +     P +V+
Sbjct: 451 LEPLLVDFFLNEPVDQVSCGDSHIMALTRSKSVYSWGCGEYGRLGL-DSEDDVYSPQKVE 509

Query: 382 LLAGEDIVQVSCGGTHSVVLTSDGRIFS 299
           +  G  IV V CG   S +LT  G++ +
Sbjct: 510 VQRGLCIVNVCCGSDGSFLLTLTGKVLA 537



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 41/142 (28%), Positives = 67/142 (47%), Gaps = 12/142 (8%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 506
           E V  ++ G  H +AL+  + +++WG  EYG+LG+        P +VE    L +V++  
Sbjct: 462 EPVDQVSCGDSHIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCC 521

Query: 505 GGWHSAALTKEGEVYAWGRGEHGRLGFG-------DDKSSHMVPLQVQL-----LAGEDI 362
           G   S  LT  G+V A G  EH +LG         + ++   VP    L     L+   I
Sbjct: 522 GSDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKI 581

Query: 361 VQVSCGGTHSVVLTSDGRIFSY 296
             +S G TH+  +   GR+ ++
Sbjct: 582 RSISPGRTHTAAIDERGRLLTF 603



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 34/138 (24%), Positives = 66/138 (47%), Gaps = 13/138 (9%)
 Frame = -2

Query: 670 IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ------------PRSQPIRV-EGLSN 530
           +  G+  +  L++   + A G NE+ +LG+                P +  + + + LS 
Sbjct: 519 VCCGSDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSF 578

Query: 529 LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 350
             +  I+ G  H+AA+ + G +  +G  + G+LG GD +    + L    L G+ +++VS
Sbjct: 579 YKIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVS 638

Query: 349 CGGTHSVVLTSDGRIFSY 296
           CG   +   T+D  IF++
Sbjct: 639 CGDEFTTAATADNHIFAW 656



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 33/129 (25%), Positives = 60/129 (46%), Gaps = 9/129 (6%)
 Frame = -2

Query: 682 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 506
           ++  I+ G  H  A+     L  +G+N+ GQLG+GD +       + G L    ++ ++ 
Sbjct: 580 KIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSC 639

Query: 505 GGWHSAALTKEGEVYAWGRGEHGRLGF--------GDDKSSHMVPLQVQLLAGEDIVQVS 350
           G   + A T +  ++AWG G +GRL           D  +S   P+   L     +  +S
Sbjct: 640 GDEFTTAATADNHIFAWGNGGNGRLAMTPNERPQGSDICTSWPRPIFGSL---HHVTDLS 696

Query: 349 CGGTHSVVL 323
           C G H++++
Sbjct: 697 CRGWHTILI 705



 Score = 30.4 bits (67), Expect = 5.9
 Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 7/80 (8%)
 Frame = -2

Query: 691 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGI-------GDTQPRSQPIRVEGLS 533
           G +QV  ++ G     A + D  ++AWGN   G+L +       G     S P  + G S
Sbjct: 630 GGKQVIRVSCGDEFTTAATADNHIFAWGNGGNGRLAMTPNERPQGSDICTSWPRPIFG-S 688

Query: 532 NLSLVDIAAGGWHSAALTKE 473
              + D++  GWH+  + ++
Sbjct: 689 LHHVTDLSCRGWHTILIVEK 708

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>GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 464

 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 58/201 (28%), Positives = 88/201 (43%), Gaps = 16/201 (7%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGN---NEYGQLGIGDTQP----RSQPIRVEGLSNL 527
           E+V  +A G  H LA +    ++ WG    +   +L  G   P      +P RV GL N 
Sbjct: 153 EKVVCVAAGLRHALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENS 212

Query: 526 SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLA----GEDIV 359
           + V   AG  HSA+LT  GE+Y WGR +HG+L       +  +PL  ++ A     E + 
Sbjct: 213 TAVCAVAGSDHSASLTDTGELYVWGRNKHGQLA----SRAVFLPLPQRIEAHYFQDEKVT 268

Query: 358 QVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGH-PMEVPINL----PPPKTSTS 194
            V  G TH V  T  G++F++            +      P+E   +L    P     + 
Sbjct: 269 AVWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLAFQGPQNSVPSP 328

Query: 193 SEGLWQANYVACGGRHTLAIV 131
              L  A  ++CG  H LA++
Sbjct: 329 LHCLTGATEISCGSEHNLAVI 349



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 36/115 (31%), Positives = 60/115 (52%), Gaps = 1/115 (0%)
 Frame = -2

Query: 640 LSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV-DIAAGGWHSAALTKEGEV 464
           +S   +L+AWG N YGQLG+G  +    P ++        +  +  GG HSA +T  G++
Sbjct: 11  VSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDL 70

Query: 463 YAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 299
           +  G  + G+LG G  +      +  + L G  I QV+CG   +++LT  G++ S
Sbjct: 71  FVCGLNKDGQLGLGHTEEVLRFTI-CKPLRGCPIRQVACGWDFTIMLTEKGQVLS 124



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 33/128 (25%), Positives = 62/128 (48%)
 Frame = -2

Query: 679 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 500
           +  +  G  H+  ++    L+  G N+ GQLG+G T+   +    + L    +  +A G 
Sbjct: 51  IKSVTGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGW 110

Query: 499 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 320
             +  LT++G+V + G    G+LG        +VP  ++ L  E +V V+ G  H++  T
Sbjct: 111 DFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLR-EKVVCVAAGLRHALATT 169

Query: 319 SDGRIFSY 296
           + G +F +
Sbjct: 170 ATGSVFQW 177



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 39/140 (27%), Positives = 65/140 (46%), Gaps = 19/140 (13%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSL----- 521
           E+V+ +  G  H +A +    ++ WG  +YGQLG     P +Q   VE  S+L+      
Sbjct: 265 EKVTAVWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQK-PVEQDSSLAFQGPQN 323

Query: 520 ------------VDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 377
                        +I+ G  H+ A+ ++ +  +WG  EHG  G G + S+   P  VQ L
Sbjct: 324 SVPSPLHCLTGATEISCGSEHNLAVIRD-KCCSWGWNEHGMCGDGTE-SNVWTPTPVQAL 381

Query: 376 --AGEDIVQVSCGGTHSVVL 323
             +   ++ V CG  HS+ +
Sbjct: 382 PPSPSRLLLVGCGAGHSLAV 401



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 22/70 (31%), Positives = 32/70 (45%), Gaps = 6/70 (8%)
 Frame = -2

Query: 493 SAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC------GGTHS 332
           S  ++    ++AWG   +G+LG G  K    +P Q+      D  Q  C      GG HS
Sbjct: 8   SETVSAAAVLFAWGANSYGQLGLG-HKEDVFLPQQL-----SDFCQAGCIKSVTGGGGHS 61

Query: 331 VVLTSDGRIF 302
            V+T  G +F
Sbjct: 62  AVVTDGGDLF 71



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
 Frame = -2

Query: 712 STPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGL- 536
           S P  +  L   + I+ G+ HNLA+  D+   +WG NE+G  G G       P  V+ L 
Sbjct: 324 SVPSPLHCLTGATEISCGSEHNLAVIRDKCC-SWGWNEHGMCGDGTESNVWTPTPVQALP 382

Query: 535 -SNLSLVDIAAGGWHSAAL 482
            S   L+ +  G  HS A+
Sbjct: 383 PSPSRLLLVGCGAGHSLAV 401

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>RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)|
          Length = 539

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 54/216 (25%), Positives = 95/216 (43%), Gaps = 18/216 (8%)
 Frame = -2

Query: 721 KNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS-QPIRV 545
           K  + P +++ L ++  +A G  H +AL+    ++ WGN +  QLG    + R  Q +  
Sbjct: 215 KRTAEPTQMR-LPEICQLATGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTP 273

Query: 544 EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGF--GDDKSSHMV--PLQVQLL 377
           + L+  +++ + AG +HS A+  +G VYAWG     + G    D++   ++  P  V  L
Sbjct: 274 QPLALKNIISVGAGSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDAL 333

Query: 376 AGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPP---- 209
            G ++  ++ G  H++ L  DGR+ ++                 H + +P N  P     
Sbjct: 334 EGYNVKSITGGEHHTLALLEDGRVLAWGRDDR------------HQLGIPDNALPETVVK 381

Query: 208 ---------KTSTSSEGLWQANYVACGGRHTLAIVT 128
                     T T   GL     V CG  H LA+ +
Sbjct: 382 DEKGNNYYLSTPTIIPGLTNVIQVVCGTHHNLAVTS 417



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 40/147 (27%), Positives = 74/147 (50%), Gaps = 16/147 (10%)
 Frame = -2

Query: 688 LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR-----SQPIRVEGLSNLS 524
           L+ +  +  G++H+ A+     ++AWG N   Q GI           ++P  V+ L   +
Sbjct: 278 LKNIISVGAGSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYN 337

Query: 523 LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGD----------DKSSHMVPLQVQLLA 374
           +  I  G  H+ AL ++G V AWGR +  +LG  D          +K ++       ++ 
Sbjct: 338 VKSITGGEHHTLALLEDGRVLAWGRDDRHQLGIPDNALPETVVKDEKGNNYYLSTPTIIP 397

Query: 373 G-EDIVQVSCGGTHSVVLTSDGRIFSY 296
           G  +++QV CG  H++ +TSDG+++S+
Sbjct: 398 GLTNVIQVVCGTHHNLAVTSDGKVYSW 424



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 46/148 (31%), Positives = 70/148 (47%), Gaps = 18/148 (12%)
 Frame = -2

Query: 715 ISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGI------------- 581
           I+ P  V  LE   V  I  G  H LAL  D  + AWG ++  QLGI             
Sbjct: 324 ITKPTLVDALEGYNVKSITGGEHHTLALLEDGRVLAWGRDDRHQLGIPDNALPETVVKDE 383

Query: 580 -GDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSH 404
            G+    S P  + GL+N+  + +  G  H+ A+T +G+VY+WG  E+  +G GD+    
Sbjct: 384 KGNNYYLSTPTIIPGLTNV--IQVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDNDEDV 441

Query: 403 MVPLQVQLLAGEDIV--QVSCGGTHSVV 326
            VP  V+  A +++       GG  S++
Sbjct: 442 AVPTLVRSKAIKEVAIRVAGAGGQFSII 469



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 43/143 (30%), Positives = 69/143 (48%), Gaps = 5/143 (3%)
 Frame = -2

Query: 709 TPVRVQG-LEQVSMIAVGAFHNL--ALSVDRILWAWGNNEY--GQLGIGDTQPRSQPIRV 545
           TP +V+G L  + +  V    NL  A++ +   + WG      G LG  D+Q R+     
Sbjct: 163 TPSKVEGALSHLRVTKVICSDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQ 222

Query: 544 EGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGED 365
             L  +    +A G  H  ALT  G+VY WG G+  +LG    +   +  L  Q LA ++
Sbjct: 223 MRLPEIC--QLATGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKN 280

Query: 364 IVQVSCGGTHSVVLTSDGRIFSY 296
           I+ V  G  HS  + + GR++++
Sbjct: 281 IISVGAGSYHSFAIDNKGRVYAW 303



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 43/164 (26%), Positives = 75/164 (45%), Gaps = 21/164 (12%)
 Frame = -2

Query: 724 IKNISTPVRVQG-LEQVSMIAVGAFHNLALSVDRI-LWAWGNNEYGQLGIGDTQ------ 569
           + ++  PVRV G  ++++ I         L  +R+ ++ +G+    +LG+G+ +      
Sbjct: 44  VSSLPKPVRVPGSAKRINKIP-------ELPTERLNVYVFGSGSMNELGMGEEEMDVVYR 96

Query: 568 PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLG--FGDDKSSHMVP 395
           PR  PI       + +VD+A GG HSAAL+ +G VY WG  +   LG    D K  +   
Sbjct: 97  PRLNPIL--STDKVGVVDLAVGGMHSAALSHDGRVYTWGVNDDYALGRLTKDQKDENGDK 154

Query: 394 LQVQLLAGED-----------IVQVSCGGTHSVVLTSDGRIFSY 296
           +   LL G             + +V C    +  +T +G  F++
Sbjct: 155 VDNDLLEGTPSKVEGALSHLRVTKVICSDNLTAAITDNGCCFTW 198

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>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9)
          Length = 984

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 45/150 (30%), Positives = 76/150 (50%), Gaps = 11/150 (7%)
 Frame = -2

Query: 712 STPVRVQGLEQ---VSMIAVGAFHNLALSVDRILWAWGNNE-----YGQLGIGDTQPRSQ 557
           STP ++  ++       +  G  H   ++V++ L+ W N +     +GQLG GD     Q
Sbjct: 357 STPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQ 416

Query: 556 PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSH---MVPLQV 386
           P  VE L   ++  ++ G   +  +T EG++YA+G   +G +G   DK S    + P+Q+
Sbjct: 417 PKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGV--DKVSGPEVLEPMQL 474

Query: 385 QLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
                  + QVSCG  H VVLT +  ++S+
Sbjct: 475 NFFLSNPVEQVSCGDNHVVVLTRNKEVYSW 504



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 39/148 (26%), Positives = 75/148 (50%), Gaps = 4/148 (2%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS- 560
           GD  +   P  V+ L+   +  ++ G    + ++ +  L+A+G++ YG +G+        
Sbjct: 409 GDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVSGPEV 468

Query: 559 -QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
            +P+++    +  +  ++ G  H   LT+  EVY+WG GE+GRLG  D +  +  P +V 
Sbjct: 469 LEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL-DSEEDYYTPQRVD 527

Query: 382 LLAGEDIVQVSCGGTHSVVLTSDGRIFS 299
           +     IV V CG   + +LT  G++ +
Sbjct: 528 VPKALIIVAVQCGCDGTFLLTQSGKVLA 555



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 36/140 (25%), Positives = 66/140 (47%), Gaps = 12/140 (8%)
 Frame = -2

Query: 679 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 500
           V  ++ G  H + L+ ++ +++WG  EYG+LG+   +    P RV+    L +V +  G 
Sbjct: 482 VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGC 541

Query: 499 WHSAALTKEGEVYAWGRGEHGRLGFG-------DDKSSHMVPLQVQL-----LAGEDIVQ 356
             +  LT+ G+V A G  E  +LG         + ++ H VP          L+   I  
Sbjct: 542 DGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRT 601

Query: 355 VSCGGTHSVVLTSDGRIFSY 296
           ++ G TH+  +   GR+ ++
Sbjct: 602 IAPGKTHTAAIDERGRLLTF 621



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 31/126 (24%), Positives = 58/126 (46%), Gaps = 6/126 (4%)
 Frame = -2

Query: 682 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 506
           ++  IA G  H  A+     L  +G N+ GQLG+G+ + R     + G L    ++ ++ 
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657

Query: 505 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ-----LLAGEDIVQVSCGG 341
           G   + A T +  ++AWG G +GRL     +  H   +          +   +  +SC G
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRG 717

Query: 340 THSVVL 323
            H++++
Sbjct: 718 WHTILI 723



 Score = 30.8 bits (68), Expect = 4.5
 Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
 Frame = -2

Query: 691 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQP-------RSQPIRVEGLS 533
           G +QV  ++ G    +A + D  ++AWGN   G+L +  T+         S P  + G S
Sbjct: 648 GGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFG-S 706

Query: 532 NLSLVDIAAGGWHSAALTKE 473
              + D++  GWH+  + ++
Sbjct: 707 LHHVPDLSCRGWHTILIVEK 726

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>ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1651

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 36/100 (36%), Positives = 57/100 (57%)
 Frame = -2

Query: 622 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 443
           +W WG  + GQLG GD  PR QP+ V+ L    ++ + AGG HS ALT + +VY+WG   
Sbjct: 522 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNT 581

Query: 442 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 323
            G+LG  +  ++  VP   ++ +   +  V+ G  +S+ L
Sbjct: 582 FGQLGHSEFPTT--VPRLSKVSSENGVWSVAAGQDYSLFL 619



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 37/122 (30%), Positives = 62/122 (50%)
 Frame = -2

Query: 469 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXX 290
           EV+ WG+G+ G+LG GD     + PL V+ L G++++ +  GG+HS+ LT+  +++S+  
Sbjct: 521 EVWTWGKGKEGQLGHGD-VLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGS 579

Query: 289 XXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVTWTDM*L 110
                         GH  E P  +P     +S  G+W    VA G  ++L +V   D   
Sbjct: 580 NTFG--------QLGH-SEFPTTVPRLSKVSSENGVWS---VAAGQDYSLFLVDTEDFQP 627

Query: 109 GI 104
           G+
Sbjct: 628 GL 629



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 50/202 (24%), Positives = 87/202 (43%), Gaps = 9/202 (4%)
 Frame = -2

Query: 709 TPVRVQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGL 536
           TP R+ G   + V   A+G  H + L+ D  ++++G   +      +  P S P+    L
Sbjct: 31  TPERLPGWGGKTVLQAALGVRHGVLLTEDGEVYSFGTLPWKSES-AEICP-SSPLLESAL 88

Query: 535 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGED--- 365
               ++ +A G +HS A+T+ G VY WG    G+    + +     P  V +   E    
Sbjct: 89  VGHHVITVATGSFHSGAVTESGVVYMWGENAAGQCAVANQQYV-PEPSPVSISDSETSPS 147

Query: 364 ----IVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTST 197
               I+Q++CG  H++ L+    I+++             +TT      P+  P      
Sbjct: 148 LAVRILQLACGEEHTLALSLSREIWAWGTGCQLGL-----ITT----TFPVTKPQKVEHL 198

Query: 196 SSEGLWQANYVACGGRHTLAIV 131
           +   + Q   VACG  H+LA+V
Sbjct: 199 AGRVVLQ---VACGAFHSLALV 217



 Score = 36.6 bits (83), Expect = 0.082
 Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
           GD+     P+ V+ L+  +V  +  G  H+LAL+    +++WG+N +GQLG  +  P + 
Sbjct: 536 GDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNTFGQLGHSEF-PTTV 594

Query: 556 PIRVEGLSNLSLVDIAAGGWHSAA 485
           P        LS V    G W  AA
Sbjct: 595 P-------RLSKVSSENGVWSVAA 611



 Score = 33.5 bits (75), Expect = 0.70
 Identities = 17/61 (27%), Positives = 30/61 (49%)
 Frame = -2

Query: 478 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 299
           K+    A G  E G +      S  + P ++    G+ ++Q + G  H V+LT DG ++S
Sbjct: 5   KKSSTEAEGSKERGLVHVWQAGSFSLTPERLPGWGGKTVLQAALGVRHGVLLTEDGEVYS 64

Query: 298 Y 296
           +
Sbjct: 65  F 65

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>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase
           8) (Nek8)
          Length = 979

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 42/148 (28%), Positives = 74/148 (50%), Gaps = 9/148 (6%)
 Frame = -2

Query: 712 STPVRVQGLEQ---VSMIAVGAFHNLALSVDRILWAWGNNE-----YGQLGIGDTQPRSQ 557
           STP ++  ++       +  G  H   ++V++ L+ W N +     +GQLG GD     Q
Sbjct: 357 STPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQ 416

Query: 556 PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV-PLQVQL 380
           P  VE L   ++  ++ G   +  +T EG++YA+G   +G +G        ++ P+Q+  
Sbjct: 417 PKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNF 476

Query: 379 LAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
                + QVSCG  H VVLT +  ++S+
Sbjct: 477 FLSNPVEQVSCGDNHVVVLTRNKEVYSW 504



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 39/148 (26%), Positives = 75/148 (50%), Gaps = 4/148 (2%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS- 560
           GD  +   P  V+ L+   +  ++ G    + ++ +  L+A+G++ YG +G+        
Sbjct: 409 GDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEV 468

Query: 559 -QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
            +P+++    +  +  ++ G  H   LT+  EVY+WG GE+GRLG  D +  +  P +V 
Sbjct: 469 LEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL-DSEEDYYTPQKVD 527

Query: 382 LLAGEDIVQVSCGGTHSVVLTSDGRIFS 299
           +     IV V CG   + +LT  G++ +
Sbjct: 528 VPKALIIVAVQCGCDGTFLLTQSGKVLA 555



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 35/140 (25%), Positives = 66/140 (47%), Gaps = 12/140 (8%)
 Frame = -2

Query: 679 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 500
           V  ++ G  H + L+ ++ +++WG  EYG+LG+   +    P +V+    L +V +  G 
Sbjct: 482 VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGC 541

Query: 499 WHSAALTKEGEVYAWGRGEHGRLGFG-------DDKSSHMVPLQVQL-----LAGEDIVQ 356
             +  LT+ G+V A G  E  +LG         + ++ H VP          L+   I  
Sbjct: 542 DGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRT 601

Query: 355 VSCGGTHSVVLTSDGRIFSY 296
           ++ G TH+  +   GR+ ++
Sbjct: 602 IAPGKTHTAAIDERGRLLTF 621



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 31/126 (24%), Positives = 58/126 (46%), Gaps = 6/126 (4%)
 Frame = -2

Query: 682 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 506
           ++  IA G  H  A+     L  +G N+ GQLG+G+ + R     + G L    ++ ++ 
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657

Query: 505 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ-----LLAGEDIVQVSCGG 341
           G   + A T +  ++AWG G +GRL     +  H   +          +   +  +SC G
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRG 717

Query: 340 THSVVL 323
            H++++
Sbjct: 718 WHTILI 723



 Score = 30.8 bits (68), Expect = 4.5
 Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
 Frame = -2

Query: 691 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQP-------RSQPIRVEGLS 533
           G +QV  ++ G    +A + D  ++AWGN   G+L +  T+         S P  + G S
Sbjct: 648 GGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFG-S 706

Query: 532 NLSLVDIAAGGWHSAALTKE 473
              + D++  GWH+  + ++
Sbjct: 707 LHHVPDLSCRGWHTILIVEK 726

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>RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 48/148 (32%), Positives = 79/148 (53%), Gaps = 5/148 (3%)
 Frame = -2

Query: 610 GNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 434
           G  + GQLG+G++   R +P  V  L ++  V   AGG H+  L + G+VY++G  + G 
Sbjct: 41  GQGDVGQLGLGESVLERKKPALVPLLQDV--VQAEAGGMHTVCLNQSGQVYSFGCNDEGA 98

Query: 433 LGFGDD-KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF---SYXXXXXXXXXX 266
           LG     + S MVP +V+L   E +VQVS G +H+  LT DGR+F   S+          
Sbjct: 99  LGRDTSVEGSEMVPGKVELQ--EKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLL 156

Query: 265 XRKVTTGHPMEVPINLPPPKTSTSSEGL 182
                +  P++V +++P  K ++ ++ L
Sbjct: 157 EPMKKSMVPVQVQLDMPVVKVASGNDHL 184



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 2/179 (1%)
 Frame = -2

Query: 661 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL--SLVDIAAGGWHSA 488
           GA+   A+S +  ++ +G + Y QLG   T     P  +    N   S V  + G  H+ 
Sbjct: 248 GAYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKNSTKSWVGFSGGQHHTI 307

Query: 487 ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 308
            +  EG+ Y+ GR E+GRLG G+      +P  +  L    +  V+CG +    ++ DGR
Sbjct: 308 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PVVSSVACGASVGYAVSKDGR 365

Query: 307 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 131
           +F++           +      P+E+        T    E       V+ GG+HT+ +V
Sbjct: 366 VFAWGMGTNYQLGTGQDEDAWSPVEM--------TGKQLENRVVLT-VSSGGQHTVLLV 415



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 2/84 (2%)
 Frame = -2

Query: 712 STPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-- 539
           S P  +  L  VS +A GA    A+S D  ++AWG     QLG G  +    P+ + G  
Sbjct: 336 SIPTLISRLPVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQ 395

Query: 538 LSNLSLVDIAAGGWHSAALTKEGE 467
           L N  ++ +++GG H+  L K+ E
Sbjct: 396 LENRVVLTVSSGGQHTVLLVKDKE 419



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 24/67 (35%), Positives = 37/67 (55%)
 Frame = -2

Query: 496 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 317
           H +  T+ G V   G+G+ G+LG G+       P  V LL  +D+VQ   GG H+V L  
Sbjct: 27  HRSHKTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLL--QDVVQAEAGGMHTVCLNQ 84

Query: 316 DGRIFSY 296
            G+++S+
Sbjct: 85  SGQVYSF 91



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 41/160 (25%), Positives = 70/160 (43%), Gaps = 18/160 (11%)
 Frame = -2

Query: 724 IKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG--------IGDTQ 569
           +K    PV+VQ    V  +A G  H + L+ D  L+  G  E GQLG         G  Q
Sbjct: 159 MKKSMVPVQVQLDMPVVKVASGNDHLVMLTTDGDLYTLGCGEQGQLGRVPELFANRGGRQ 218

Query: 568 -------PRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK 413
                  P+   ++  G    +   D   G + + A+++EG VY +G   + +LG     
Sbjct: 219 GLERLLVPKCVLLKSRGSRGRVRFQDAFCGAYLTFAISREGHVYGFGLSNYHQLG-TPGT 277

Query: 412 SSHMVPLQVQLL--AGEDIVQVSCGGTHSVVLTSDGRIFS 299
           +S  +P  +     + +  V  S G  H++ + S+G+ +S
Sbjct: 278 ASCFIPQNLTSFKNSTKSWVGFSGGQHHTICMDSEGKAYS 317

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>RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromosome|
           condensation protein 1) (Cell cycle regulatory protein)
          Length = 421

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 48/148 (32%), Positives = 78/148 (52%), Gaps = 5/148 (3%)
 Frame = -2

Query: 610 GNNEYGQLGIGDT-QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 434
           G  + GQLG+G+    R +P  V    ++  V   AGG H+  L+K G+VY++G  + G 
Sbjct: 41  GQGDVGQLGLGENVMERKKPALVSIPEDV--VQAEAGGMHTVCLSKSGQVYSFGCNDEGA 98

Query: 433 LGFGDD-KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF---SYXXXXXXXXXX 266
           LG     + S MVP +V+L   E +VQVS G +H+  LT DGR+F   S+          
Sbjct: 99  LGRDTSVEGSEMVPGKVEL--QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLL 156

Query: 265 XRKVTTGHPMEVPINLPPPKTSTSSEGL 182
                +  P++V +++P  K ++ ++ L
Sbjct: 157 EPMKKSMVPVQVQLDVPVVKVASGNDHL 184



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 46/179 (25%), Positives = 79/179 (44%), Gaps = 2/179 (1%)
 Frame = -2

Query: 661 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL--SLVDIAAGGWHSA 488
           GA+   A+S +  ++ +G + Y QLG   T+    P  +    N   S V  + G  H+ 
Sbjct: 248 GAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTV 307

Query: 487 ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 308
            +  EG+ Y+ GR E+GRLG G+      +P  +  L    +  V+CG +    +T DGR
Sbjct: 308 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGR 365

Query: 307 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 131
           +F++           +      P+E+       +   S         V+ GG+HT+ +V
Sbjct: 366 VFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS---------VSSGGQHTVLLV 415



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 27/84 (32%), Positives = 43/84 (51%), Gaps = 2/84 (2%)
 Frame = -2

Query: 712 STPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-- 539
           S P  +  L  VS +A GA    A++ D  ++AWG     QLG G  +    P+ + G  
Sbjct: 336 SIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQ 395

Query: 538 LSNLSLVDIAAGGWHSAALTKEGE 467
           L N  ++ +++GG H+  L K+ E
Sbjct: 396 LENRVVLSVSSGGQHTVLLVKDKE 419



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 23/67 (34%), Positives = 38/67 (56%)
 Frame = -2

Query: 496 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 317
           H +  T+ G V   G+G+ G+LG G++      P  V +   ED+VQ   GG H+V L+ 
Sbjct: 27  HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSK 84

Query: 316 DGRIFSY 296
            G+++S+
Sbjct: 85  SGQVYSF 91



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 42/160 (26%), Positives = 70/160 (43%), Gaps = 18/160 (11%)
 Frame = -2

Query: 724 IKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG--------IGDTQ 569
           +K    PV+VQ    V  +A G  H + L+ D  L+  G  E GQLG         G  Q
Sbjct: 159 MKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQ 218

Query: 568 -------PRSQPIRVEG-LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK 413
                  P+   ++  G   ++   D   G + + A++ EG VY +G   + +LG    +
Sbjct: 219 GLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTE 278

Query: 412 SSHMVPLQVQLL--AGEDIVQVSCGGTHSVVLTSDGRIFS 299
           S   +P  +     + +  V  S G  H+V + S+G+ +S
Sbjct: 279 SC-FIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYS 317

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>RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 48/148 (32%), Positives = 79/148 (53%), Gaps = 5/148 (3%)
 Frame = -2

Query: 610 GNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 434
           G  + GQLG+G++   R +P  V  L ++  V   AGG H+  L++ G+VY++G  + G 
Sbjct: 41  GQGDVGQLGLGESVLERKKPALVPLLQDV--VQAEAGGMHTVCLSQSGQVYSFGCNDEGA 98

Query: 433 LGFGDD-KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF---SYXXXXXXXXXX 266
           LG     + S MVP +V+L   E +VQVS G +H+  LT DGR+F   S+          
Sbjct: 99  LGRDTSVEGSEMVPGKVELQ--EKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLL 156

Query: 265 XRKVTTGHPMEVPINLPPPKTSTSSEGL 182
                +  P++V ++ P  K ++ ++ L
Sbjct: 157 EPMKKSMVPVQVQLDAPVVKVASGNDHL 184



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 2/179 (1%)
 Frame = -2

Query: 661 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL--SLVDIAAGGWHSA 488
           GA+   A+S +  ++ +G + Y QLG   T     P  +    N   S V  + G  H+ 
Sbjct: 248 GAYFTFAISREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNSTKSWVGFSGGQHHTV 307

Query: 487 ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 308
            +  EG+ Y+ GR E+GRLG G+      +P  +  L    +  V+CG +    ++ DGR
Sbjct: 308 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PVVSSVACGASVGYAVSKDGR 365

Query: 307 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 131
           +F++           +      P+E+        T    E       V+ GG+HT+ +V
Sbjct: 366 VFAWGMGTNYQLGTGQDEDAWSPVEM--------TGKQLENRVVLT-VSSGGQHTVLLV 415



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 24/67 (35%), Positives = 38/67 (56%)
 Frame = -2

Query: 496 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 317
           H +  T+ G V   G+G+ G+LG G+       P  V LL  +D+VQ   GG H+V L+ 
Sbjct: 27  HRSHNTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLL--QDVVQAEAGGMHTVCLSQ 84

Query: 316 DGRIFSY 296
            G+++S+
Sbjct: 85  SGQVYSF 91



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 2/82 (2%)
 Frame = -2

Query: 712 STPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-- 539
           S P  +  L  VS +A GA    A+S D  ++AWG     QLG G  +    P+ + G  
Sbjct: 336 SIPTLISRLPVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQ 395

Query: 538 LSNLSLVDIAAGGWHSAALTKE 473
           L N  ++ +++GG H+  L K+
Sbjct: 396 LENRVVLTVSSGGQHTVLLVKD 417



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 43/160 (26%), Positives = 69/160 (43%), Gaps = 18/160 (11%)
 Frame = -2

Query: 724 IKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG--------IGDTQ 569
           +K    PV+VQ    V  +A G  H + L+ D  L+  G  E GQLG         G  Q
Sbjct: 159 MKKSMVPVQVQLDAPVVKVASGNDHLVMLTNDGDLYTLGCGEQGQLGRVPELFANRGGRQ 218

Query: 568 -------PRSQPIRVEGL-SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK 413
                  PR   ++  G    +   D   G + + A+++EG VY +G   + +LG     
Sbjct: 219 GLGRLLVPRCVLLKSRGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLG-TPGT 277

Query: 412 SSHMVPLQVQLL--AGEDIVQVSCGGTHSVVLTSDGRIFS 299
            S  +P  +     + +  V  S G  H+V + S+G+ +S
Sbjct: 278 GSCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYS 317

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>RCC1_XENLA (P25183) Regulator of chromosome condensation|
          Length = 424

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 49/148 (33%), Positives = 74/148 (50%), Gaps = 5/148 (3%)
 Frame = -2

Query: 610 GNNEYGQLGIG-DTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 434
           G  + GQLG+G D   R +P  V    ++  V  AAGG H+  L   G +Y +G  + G 
Sbjct: 47  GQGDVGQLGLGEDIMERKKPALVTLTEDI--VQAAAGGMHTVCLGASGSIYTFGCNDEGA 104

Query: 433 LGFG-DDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF---SYXXXXXXXXXX 266
           LG    ++ S M P +V+L   E +VQVS G +H+  LT DGR+F   S+          
Sbjct: 105 LGRDTSEEGSEMQPGKVEL--AEKVVQVSAGDSHTAALTEDGRVFVFGSFRDNNGVIGLL 162

Query: 265 XRKVTTGHPMEVPINLPPPKTSTSSEGL 182
                +  P++V IN P  K ++ ++ L
Sbjct: 163 EPMKKSMVPVQVQINTPVIKIASGNDHL 190



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 47/179 (26%), Positives = 81/179 (45%), Gaps = 2/179 (1%)
 Frame = -2

Query: 661 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL--SLVDIAAGGWHSA 488
           GA+   A+S +  ++ +G + Y QLG  +TQ    P  +    N   S +  + G  H+ 
Sbjct: 253 GAYFTFAVSQEGHVYGFGLSNYHQLGTKNTQACYAPQNLTSFKNSTKSWIGFSGGQHHTV 312

Query: 487 ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 308
            +  EG+ Y+ GR E+GRLG G++      P  +  L    I  V+ G + S  +++DG 
Sbjct: 313 CVDSEGKAYSLGRAEYGRLGLGENAEEQSEPTPIPDL--PKINSVASGASVSYAVSTDGC 370

Query: 307 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 131
           +F++             +  G   E  +  P   T    E   +   V+ GG+HT+ +V
Sbjct: 371 VFAW--------GMGTNLQLGTGEEEDVWSPEQMTGKHLEDR-EVLSVSSGGQHTVLLV 420



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 40/159 (25%), Positives = 73/159 (45%), Gaps = 17/159 (10%)
 Frame = -2

Query: 724 IKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ-------- 569
           +K    PV+VQ    V  IA G  H + L+VD  L+  G  E GQLG    +        
Sbjct: 165 MKKSMVPVQVQINTPVIKIASGNDHLVLLTVDGDLYTSGCGEQGQLGRVPERFTNRGGRK 224

Query: 568 -------PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKS 410
                  P+   ++ +G   +   D+  G + + A+++EG VY +G   + +LG  + ++
Sbjct: 225 GLERLLVPQCIHLKAKGSGRVHFQDVFCGAYFTFAVSQEGHVYGFGLSNYHQLGTKNTQA 284

Query: 409 SHMVPLQVQLL--AGEDIVQVSCGGTHSVVLTSDGRIFS 299
            +  P  +     + +  +  S G  H+V + S+G+ +S
Sbjct: 285 CY-APQNLTSFKNSTKSWIGFSGGQHHTVCVDSEGKAYS 322



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 26/67 (38%), Positives = 38/67 (56%)
 Frame = -2

Query: 496 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 317
           H +  T  G+V   G+G+ G+LG G+D      P  V L   EDIVQ + GG H+V L +
Sbjct: 33  HPSHGTVGGQVLTLGQGDVGQLGLGEDIMERKKPALVTLT--EDIVQAAAGGMHTVCLGA 90

Query: 316 DGRIFSY 296
            G I+++
Sbjct: 91  SGSIYTF 97



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 23/82 (28%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
 Frame = -2

Query: 712 STPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-- 539
           S P  +  L +++ +A GA  + A+S D  ++AWG     QLG G+ +    P ++ G  
Sbjct: 341 SEPTPIPDLPKINSVASGASVSYAVSTDGCVFAWGMGTNLQLGTGEEEDVWSPEQMTGKH 400

Query: 538 LSNLSLVDIAAGGWHSAALTKE 473
           L +  ++ +++GG H+  L ++
Sbjct: 401 LEDREVLSVSSGGQHTVLLVRK 422

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>HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-) (Protein|
            pam/highwire/rpm-1)
          Length = 5233

 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 34/84 (40%), Positives = 52/84 (61%)
 Frame = -2

Query: 679  VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 500
            V  +A G  H + L++   ++ +G+N+YGQLG GD QP S P+RV+    +S   +AAG 
Sbjct: 968  VVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQVPGAIS--QVAAGS 1025

Query: 499  WHSAALTKEGEVYAWGRGEHGRLG 428
             H+  LT +G VY +G  + G+LG
Sbjct: 1026 NHTVLLTSKGMVYTFGNYQKGQLG 1049



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 34/94 (36%), Positives = 55/94 (58%), Gaps = 3/94 (3%)
 Frame = -2

Query: 568  PRSQPIRVEGL---SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 398
            PR  P+  + L   S+  +V +A G  H+  LT  GEVY +G  ++G+LG GD +     
Sbjct: 950  PRVAPLAPQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSG- 1008

Query: 397  PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
            P++VQ+     I QV+ G  H+V+LTS G ++++
Sbjct: 1009 PVRVQVPGA--ISQVAAGSNHTVLLTSKGMVYTF 1040



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 19/49 (38%), Positives = 32/49 (65%)
 Frame = -2

Query: 730  GDIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG 584
            GD++ +S PVRVQ    +S +A G+ H + L+   +++ +GN + GQLG
Sbjct: 1001 GDLQPVSGPVRVQVPGAISQVAAGSNHTVLLTSKGMVYTFGNYQKGQLG 1049

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>RCC1_DROME (P25171) Regulator of chromosome condensation (Chromatin-binding|
           protein Bj1)
          Length = 547

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 9/142 (6%)
 Frame = -2

Query: 697 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 518
           V G+     I+ G  HNL L+    ++++G N+ G LG   ++  S+       S   L+
Sbjct: 70  VAGIPDAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSE-------SKPDLI 122

Query: 517 D-------IAAGGWHSAALTKEGEVYAWG--RGEHGRLGFGDDKSSHMVPLQVQLLAGED 365
           D       I+AG  HSA L ++G V+AWG  R  HG +G   D +       + L+ G  
Sbjct: 123 DLPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKR---TPIDLMEGTV 179

Query: 364 IVQVSCGGTHSVVLTSDGRIFS 299
              ++ G  H V+LT+ G++F+
Sbjct: 180 CCSIASGADHLVILTTAGKVFT 201



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 39/111 (35%), Positives = 60/111 (54%), Gaps = 6/111 (5%)
 Frame = -2

Query: 610 GNNEYGQLGIG-DTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 434
           GN + GQLG+G D   R +   V G+ +   VDI+AGG H+  LTK G++Y++G  + G 
Sbjct: 48  GNGDVGQLGLGEDILERKRLSPVAGIPDA--VDISAGGMHNLVLTKSGDIYSFGCNDEGA 105

Query: 433 LG-----FGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
           LG      G +    ++ L  + L       +S G +HS  L  DGR+F++
Sbjct: 106 LGRDTSEDGSESKPDLIDLPGKALC------ISAGDSHSACLLEDGRVFAW 150



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 41/131 (31%), Positives = 71/131 (54%), Gaps = 2/131 (1%)
 Frame = -2

Query: 709 TPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQP-RSQPIRVEGLS 533
           TP++ + L+ +  IA G  H + L+ D      G  EYG+LG+GD +    +P  V+ L+
Sbjct: 286 TPIKTE-LKDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLT 344

Query: 532 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGD-DKSSHMVPLQVQLLAGEDIVQ 356
              +V +  G   S A+T +G++Y+WG G + +LG GD D     + +  +   G+ ++ 
Sbjct: 345 E-KIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLL 403

Query: 355 VSCGGTHSVVL 323
            S GG H++ L
Sbjct: 404 ASGGGQHAIFL 414



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 42/117 (35%), Positives = 62/117 (52%), Gaps = 3/117 (2%)
 Frame = -2

Query: 637 SVDRILWAWGNNEYGQLGIGDTQPRS---QPIRVEGLSNLSLVDIAAGGWHSAALTKEGE 467
           S  +++WA G N + QL   +T+ +     PI+ E L ++    IA G  H+  LT + +
Sbjct: 258 SQTQVIWATGLNNFKQLA-HETKGKEFALTPIKTE-LKDIR--HIAGGQHHTVILTTDLK 313

Query: 466 VYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
               GR E+GRLG GD K     P  V+ L  E IV V CG   S  +T DG+++S+
Sbjct: 314 CSVVGRPEYGRLGLGDVKDVVEKPTIVKKLT-EKIVSVGCGEVCSYAVTIDGKLYSW 369



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 26/89 (29%), Positives = 47/89 (52%), Gaps = 4/89 (4%)
 Frame = -2

Query: 730 GDIKNI-STPVRVQGL-EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ 557
           GD+K++   P  V+ L E++  +  G   + A+++D  L++WG+    QLG+GD     +
Sbjct: 328 GDVKDVVEKPTIVKKLTEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELE 387

Query: 556 PIRV--EGLSNLSLVDIAAGGWHSAALTK 476
           PI V  +      ++  + GG H+  L K
Sbjct: 388 PIVVVSKNTQGKHMLLASGGGQHAIFLVK 416



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 23/60 (38%), Positives = 34/60 (56%), Gaps = 1/60 (1%)
 Frame = -2

Query: 472 GEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAG-EDIVQVSCGGTHSVVLTSDGRIFSY 296
           G V   G G+ G+LG G+D        ++  +AG  D V +S GG H++VLT  G I+S+
Sbjct: 42  GNVLVCGNGDVGQLGLGEDILERK---RLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSF 98

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>RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 protein)|
           (Pheromone response pathway component SRM1)
          Length = 482

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 45/147 (30%), Positives = 70/147 (47%), Gaps = 15/147 (10%)
 Frame = -2

Query: 691 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG----DTQPRSQPIRVEGLSNLS 524
           GL  V  IA G  H  AL+ D  L +WG N++GQ G+     D    ++P R+    N+ 
Sbjct: 272 GLRHVKYIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVV 331

Query: 523 LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK-----------SSHMVPLQVQLL 377
           +  IAAG  HS  L+++G++Y+ GR +   +G   D             +  VPL  +L 
Sbjct: 332 IRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLN 391

Query: 376 AGEDIVQVSCGGTHSVVLTSDGRIFSY 296
                  V+ G  HSV +  +G  +S+
Sbjct: 392 NVPKFKSVAAGSHHSVAVAQNGIAYSW 418



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 48/161 (29%), Positives = 71/161 (44%), Gaps = 32/161 (19%)
 Frame = -2

Query: 682 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ------------------ 557
           ++   AVG  H LAL  +  +W+WG N+ G LG   +  + Q                  
Sbjct: 85  KIISFAVGGMHTLALDEESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLN 144

Query: 556 -----PIRV--EGLSNLS----LVDIAAGGWHSAALTKEGEVYAWG--RGEHGRLGFGDD 416
                P ++  E    L+    +V +AA    S AL   GEVYAWG  R   G LGF  D
Sbjct: 145 ELESTPAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNEGILGFYQD 204

Query: 415 K-SSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
           K      P +V   +  +IVQ++ G  H + L  +G +F++
Sbjct: 205 KIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAW 245



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 43/131 (32%), Positives = 63/131 (48%), Gaps = 14/131 (10%)
 Frame = -2

Query: 679 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG-DTQPRSQPIRVEG----------LS 533
           +  IA G  H+L LS D  L++ G  +  ++GI  D  P      V G          L+
Sbjct: 332 IRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLN 391

Query: 532 NL-SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGED--I 362
           N+     +AAG  HS A+ + G  Y+WG GE   +G G  +    VP +++  A +D  I
Sbjct: 392 NVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEVPTRIKNTATQDHNI 451

Query: 361 VQVSCGGTHSV 329
           + V CGG  SV
Sbjct: 452 ILVGCGGQFSV 462



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 43/159 (27%), Positives = 73/159 (45%), Gaps = 14/159 (8%)
 Frame = -2

Query: 730 GDIKNI-STPVRVQG------LEQVSMIAVGAFHNL--ALSVDRILWAWGN---NEYGQL 587
           GD+  + STP ++         E   ++ + A  N+  AL  +  ++AWG    NE G L
Sbjct: 141 GDLNELESTPAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNE-GIL 199

Query: 586 GIGDTQPRSQ--PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK 413
           G    + + Q  P +V   S  ++V +A G  H   L +EG V+AWG G+  +LG    +
Sbjct: 200 GFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAWGNGQQNQLGRKVME 259

Query: 412 SSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
              +  L  +      +  ++ G  H   LT D ++ S+
Sbjct: 260 RFRLKTLDPRPFGLRHVKYIASGENHCFALTKDNKLVSW 298



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 35/156 (22%), Positives = 62/156 (39%), Gaps = 36/156 (23%)
 Frame = -2

Query: 655 FHNLALSVDRI-LWAWGNNEYGQLGIGDT-------QPRSQPIRVEGLSNLSLVDIAAGG 500
           + ++ LSV  + ++ WG     +LG+G         +PR  P          ++  A GG
Sbjct: 36  YKHMYLSVQPLDIFCWGTGSMCELGLGPLAKNKEVKRPRLNPFLPR--DEAKIISFAVGG 93

Query: 499 WHSAALTKEGEVYAWGRGEHGRLG-----------------FGDDKSSHMVPLQ------ 389
            H+ AL +E  V++WG  + G LG                   DD+   +  L+      
Sbjct: 94  MHTLALDEESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLNELESTPAKI 153

Query: 388 -----VQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
                  L  G  +VQ++     S  L S+G ++++
Sbjct: 154 PRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAW 189



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 17/85 (20%), Positives = 46/85 (54%), Gaps = 3/85 (3%)
 Frame = -2

Query: 730 GDIKNISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ-P 554
           G  + +  P ++  + +   +A G+ H++A++ + I ++WG  E   +G+G  +  ++ P
Sbjct: 379 GKARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEVP 438

Query: 553 IRVEGLS--NLSLVDIAAGGWHSAA 485
            R++  +  + +++ +  GG  S +
Sbjct: 439 TRIKNTATQDHNIILVGCGGQFSVS 463

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>WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 16 protein|
           homolog
          Length = 461

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 51/181 (28%), Positives = 83/181 (45%), Gaps = 4/181 (2%)
 Frame = -2

Query: 682 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG--IGDTQPRSQPIRVEGLSNLS--LVD 515
           +V  ++ G  H+L L+    +++ GNN +GQ G  + + +  S+  +V  + +    +V 
Sbjct: 172 KVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVHRMQDFDGQVVQ 231

Query: 514 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH 335
           +  G  HS  LT +GEVY+ G G  G+ G G    +         LAG  +VQV+  G  
Sbjct: 232 VVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVATYGDC 291

Query: 334 SVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACG 155
            + L++DG +F +             VT    + VP  LP         G+ +   VACG
Sbjct: 292 CLALSADGGVFGW---GNSEYLQLASVTDSTQVNVPRCLP-------FSGVGKVKQVACG 341

Query: 154 G 152
           G
Sbjct: 342 G 342



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 39/128 (30%), Positives = 65/128 (50%), Gaps = 1/128 (0%)
 Frame = -2

Query: 682 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 506
           QV  +  G  H+L L+    +++ G    GQ G+G     S P ++ G L+ +++V +A 
Sbjct: 228 QVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVAT 287

Query: 505 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVV 326
            G    AL+ +G V+ WG  E+ +L    D +   VP  +       + QV+CGGT   V
Sbjct: 288 YGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGKVKQVACGGTGCAV 347

Query: 325 LTSDGRIF 302
           L ++G +F
Sbjct: 348 LNAEGHVF 355



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 43/141 (30%), Positives = 65/141 (46%), Gaps = 9/141 (6%)
 Frame = -2

Query: 718 NISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ-----PRSQP 554
           N+   +   G+ +V  +A G      L+ +  ++ WG   YG LG G        P   P
Sbjct: 322 NVPRCLPFSGVGKVKQVACGGTGCAVLNAEGHVFVWG---YGILGKGPKLLETAIPEMIP 378

Query: 553 IRVEGLSNLS----LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQV 386
             + GL+  +    +  I  G  H AALT +GE++ WG+   G LG G  +  +  P +V
Sbjct: 379 PTLFGLTEFNPEVQVSQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYF-PWRV 437

Query: 385 QLLAGEDIVQVSCGGTHSVVL 323
             + GE  V V+CG  H V L
Sbjct: 438 -TMPGEP-VDVACGVDHMVTL 456



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 20/156 (12%)
 Frame = -2

Query: 706 PVRVQGLEQVSMIAVGAFHNLALSVDRIL---WAWGNNEYGQLGIGDT------------ 572
           P R++   ++S  A G    L  S  + +   W  G N+  QLG   +            
Sbjct: 97  PYRLELDHKISSAACGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 156

Query: 571 QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLG---FGDD--KSS 407
           +P   P+ ++      ++ ++ G  HS  LT    V++ G   HG+ G     D+    S
Sbjct: 157 EPSPVPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSES 216

Query: 406 HMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 299
           H V  ++Q   G+ +VQV CG  HS+ LT  G ++S
Sbjct: 217 HKVH-RMQDFDGQ-VVQVVCGQDHSLFLTDKGEVYS 250



 Score = 33.5 bits (75), Expect = 0.70
 Identities = 37/144 (25%), Positives = 58/144 (40%), Gaps = 29/144 (20%)
 Frame = -2

Query: 643 ALSVDRILWAWGNNEYGQLGI-------------GDTQPRSQ----PIRVEGLSNLSLVD 515
           A   DR+ + WG +  G LG+                +PR +    P R+E    +S   
Sbjct: 52  AARADRV-FVWGFSFSGALGVPSFVVPSSGPGPRAGLRPRRRIQPVPYRLELDHKISSAA 110

Query: 514 IAAGGWHSAALTKE-GEVYAWGRGEHGRLGFGDDKSSHM-----------VPLQVQLLAG 371
              G    ++ TK+  +V+  G  +  +LGF   +               VPL +     
Sbjct: 111 CGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVPLPLDRPQE 170

Query: 370 EDIVQVSCGGTHSVVLTSDGRIFS 299
             ++QVSCG  HS+VLT    +FS
Sbjct: 171 TKVLQVSCGRAHSLVLTDREGVFS 194

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>WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 16 protein|
          Length = 464

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 52/192 (27%), Positives = 87/192 (45%), Gaps = 4/192 (2%)
 Frame = -2

Query: 715 ISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG--IGDTQPRSQPIRVE 542
           +S P+      +V  ++ G  H+L L+    +++ GNN YGQ G  + + +  S+  RV 
Sbjct: 164 VSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVH 223

Query: 541 GLSNL--SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGE 368
            + +    +V +A G  HS  LT +GEVY+ G G  G+ G G    +         LAG 
Sbjct: 224 RMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283

Query: 367 DIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSE 188
           +++QV+  G   + +++DG +F +             VT    + VP  L          
Sbjct: 284 NVIQVATYGDCCLAVSADGGLFGW---GNSEYLQLASVTDSTQVNVPRCL-------HFS 333

Query: 187 GLWQANYVACGG 152
           G+ +    ACGG
Sbjct: 334 GVGKVRQAACGG 345



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 36/128 (28%), Positives = 64/128 (50%), Gaps = 1/128 (0%)
 Frame = -2

Query: 682 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 506
           QV  +A G  H+L L+    +++ G    GQ G+G     S P ++ G L+ ++++ +A 
Sbjct: 231 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 290

Query: 505 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVV 326
            G    A++ +G ++ WG  E+ +L    D +   VP  +       + Q +CGGT   V
Sbjct: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAV 350

Query: 325 LTSDGRIF 302
           L  +G +F
Sbjct: 351 LNGEGHVF 358



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 43/141 (30%), Positives = 64/141 (45%), Gaps = 9/141 (6%)
 Frame = -2

Query: 718 NISTPVRVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG-----DTQPRSQP 554
           N+   +   G+ +V   A G      L+ +  ++ WG   YG LG G        P   P
Sbjct: 325 NVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIP 381

Query: 553 IRVEGLSN----LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQV 386
             + GL+     + +  I  G  H AALT +GE++ WG+   G LG G  +  +  P +V
Sbjct: 382 PTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYF-PWRV 440

Query: 385 QLLAGEDIVQVSCGGTHSVVL 323
             + GE  V V+CG  H V L
Sbjct: 441 -TMPGEP-VDVACGVDHMVTL 459



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 40/157 (25%), Positives = 71/157 (45%), Gaps = 21/157 (13%)
 Frame = -2

Query: 706 PVRVQGLEQVSMIAVGAFHNLALS----VDRILWAWGNNEYGQLGIGDT----------- 572
           P R++  +++S  A G    L  S    V ++ W  G N+  QLG   +           
Sbjct: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKV-WGMGLNKDSQLGFHRSRKDKTRGYEYV 158

Query: 571 -QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKS----- 410
            +P    + ++      ++ ++ G  HS  LT    V++ G   +G+ G    ++     
Sbjct: 159 LEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSE 218

Query: 409 SHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 299
           SH V  ++Q   G+ +VQV+CG  HS+ LT  G ++S
Sbjct: 219 SHRVH-RMQDFDGQ-VVQVACGQDHSLFLTDKGEVYS 253

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>MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4641

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 43/132 (32%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
 Frame = -2

Query: 529  LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 350
            L  V ++ G  HS  L + G+VY +G G+HG+LG G D +S   P  VQ L G    QV+
Sbjct: 902  LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPS-TQVT 959

Query: 349  CGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHP-MEVPI--NLPPPKTSTSSEGLW 179
             G  H+ VL  DG++F++            K   G P ++VP     P P  +  S+   
Sbjct: 960  AGSNHTAVLLMDGQVFTF--------GSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGR 1011

Query: 178  QANYVACGGRHT 143
            +A ++   G  T
Sbjct: 1012 KATWIGASGDQT 1023



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 26/81 (32%), Positives = 44/81 (54%)
 Frame = -2

Query: 670  IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 491
            ++ G  H++ L  +  ++ +G  ++GQLG GD   R  P  V+ L   S   + AG  H+
Sbjct: 907  VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSNHT 965

Query: 490  AALTKEGEVYAWGRGEHGRLG 428
            A L  +G+V+ +G    G+LG
Sbjct: 966  AVLLMDGQVFTFGSFSKGQLG 986



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 28/123 (22%), Positives = 56/123 (45%), Gaps = 4/123 (3%)
 Frame = -2

Query: 652 HNLALSVDRILWAWGNNEYGQLGIGDTQPRS----QPIRVEGLSNLSLVDIAAGGWHSAA 485
           H L ++ D  ++  G+   G+ G      R     +P ++  +    +V  A     S+ 
Sbjct: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 484 LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRI 305
           ++K+GE+Y +G+          D SS +  L+     G  + QV+ G  H+ VL  +G +
Sbjct: 615 ISKDGELYMFGKD-----AIYSDSSSLVTDLK-----GHFVTQVAMGKAHTCVLMKNGEV 664

Query: 304 FSY 296
           +++
Sbjct: 665 WTF 667

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>RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-)|
            (Pam/highwire/rpm-1 protein) (Regulator of presynaptic
            morphology protein 1) (Synapse defective protein 3)
          Length = 3766

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 30/84 (35%), Positives = 52/84 (61%)
 Frame = -2

Query: 682  QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG 503
            +VS ++ G FH + L+ DR ++ +G+N +GQLG+GDT  ++ P +V   S+  +V +AAG
Sbjct: 768  KVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAAG 827

Query: 502  GWHSAALTKEGEVYAWGRGEHGRL 431
              H+     +G V+ +G    G+L
Sbjct: 828  SNHTILRANDGSVFTFGAFGKGQL 851



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 28/89 (31%), Positives = 51/89 (57%)
 Frame = -2

Query: 562  SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 383
            S+ I  +G  ++ +  ++ G +H+  L  +  V+ +G   HG+LG GD  S +  P QV 
Sbjct: 756  SRVILSQGPHDVKVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKN-TPQQVI 814

Query: 382  LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 296
            L +   IVQV+ G  H+++  +DG +F++
Sbjct: 815  LPSDTVIVQVAAGSNHTILRANDGSVFTF 843

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>MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4711

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 41/132 (31%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
 Frame = -2

Query: 529  LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 350
            L  V ++ G  HS  L + G+VY +G G+HG+LG G D +S   P  VQ L G    QV+
Sbjct: 902  LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPS-TQVT 959

Query: 349  CGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHP-MEVPI--NLPPPKTSTSSEGLW 179
                H+ VL  DG++F++            K   G P +++P     P P  +  S+   
Sbjct: 960  ACSNHTAVLLMDGQVFTF--------GSFSKGQLGRPILDIPYWNAKPAPMPNIGSKYGR 1011

Query: 178  QANYVACGGRHT 143
            +A ++   G  T
Sbjct: 1012 KATWIGASGDQT 1023



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 25/81 (30%), Positives = 43/81 (53%)
 Frame = -2

Query: 670  IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 491
            ++ G  H++ L  +  ++ +G  ++GQLG GD   R  P  V+ L   S   + A   H+
Sbjct: 907  VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTACSNHT 965

Query: 490  AALTKEGEVYAWGRGEHGRLG 428
            A L  +G+V+ +G    G+LG
Sbjct: 966  AVLLMDGQVFTFGSFSKGQLG 986



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 29/123 (23%), Positives = 55/123 (44%), Gaps = 4/123 (3%)
 Frame = -2

Query: 652 HNLALSVDRILWAWGNNEYGQLGIGDTQPRS----QPIRVEGLSNLSLVDIAAGGWHSAA 485
           H L ++ D  ++  G+   G+ G      R     +P ++  +    +V  A     S+ 
Sbjct: 555 HALLVAEDGSVFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 484 LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRI 305
           ++K+GE+Y +G+          D SS      V  L G  + QV+ G  H+ VL  +G +
Sbjct: 615 ISKDGELYMFGKD-----AIYSDSSS-----LVSDLKGHFVTQVAMGKAHTCVLMKNGEV 664

Query: 304 FSY 296
           +++
Sbjct: 665 WTF 667

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>ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)|
          Length = 333

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 3/110 (2%)
 Frame = -2

Query: 622 LWAWGNNEYGQLGIGDTQPRSQPIR-VEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRG 446
           ++A+G+N   QLG+G  +    P R V G     +  IA GG HS  LT +G +   G  
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDN 63

Query: 445 EHGRLGFGD--DKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 302
             G L       +     P++V       +V V+CG   +V++ +DGR++
Sbjct: 64  RRGELDSAQALRQVHDWRPVEVP----APVVDVACGWDTTVIVDADGRVW 109



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 29/111 (26%), Positives = 45/111 (40%)
 Frame = -2

Query: 466 VYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXX 287
           VYA+G     +LG G D+        V    G  + +++CGG HSV+LT+DG +      
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDN 63

Query: 286 XXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 134
                   + +   H    P+ +P P              VACG   T+ +
Sbjct: 64  RRGELDSAQALRQVHDWR-PVEVPAPVVD-----------VACGWDTTVIV 102

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>RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell cycle|
           regulatory protein) (RCC1 homolog)
          Length = 569

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 42/146 (28%), Positives = 62/146 (42%), Gaps = 11/146 (7%)
 Frame = -2

Query: 700 RVQGLEQVSMIAVGAFHNL---ALSVDRILWAWGNNEYGQLGIGDTQ-PRSQPI-RVEGL 536
           +  G +Q  ++A    ++L   ++  DR+L        G  G   T+ PR   I   EGL
Sbjct: 126 KTPGRKQAKLVAPLLTYDLFAPSIIGDRVLSCGEGEALGHPGRTTTKKPRKVDIFEEEGL 185

Query: 535 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGF------GDDKSSHMVPLQVQLLA 374
             L  V   AGG HSA LT EGEVY  G  E G +        G       V  +  +  
Sbjct: 186 KPLQAV---AGGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAKVKFEEDIEK 242

Query: 373 GEDIVQVSCGGTHSVVLTSDGRIFSY 296
              IV ++ G + +  LT  G + ++
Sbjct: 243 EGKIVMLAAGASFTAALTDQGSVIAW 268



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 35/143 (24%), Positives = 66/143 (46%), Gaps = 10/143 (6%)
 Frame = -2

Query: 694 QGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQL---GIGDTQPRSQPIRVEGLSNLS 524
           +GL+ +  +A G  H+  L+ +  ++  G NE G +   G+       +  +V+   ++ 
Sbjct: 183 EGLKPLQAVA-GGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAKVKFEEDIE 241

Query: 523 ----LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV---PLQVQLLAGED 365
               +V +AAG   +AALT +G V AWG   +           H +   P+ +   A   
Sbjct: 242 KEGKIVMLAAGASFTAALTDQGSVIAWGNLRNSNGNVDVHPLLHKMQEAPVVIVHQAKRK 301

Query: 364 IVQVSCGGTHSVVLTSDGRIFSY 296
           IV+++ G  H V+L   G + ++
Sbjct: 302 IVKIAAGENHLVMLDEKGCLLTF 324



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 36/134 (26%), Positives = 58/134 (43%), Gaps = 11/134 (8%)
 Frame = -2

Query: 691 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG------DTQPRSQPIRVEGLSN 530
           G E+  +   G  H + L  D  ++A G N    LG+G      D Q        E   +
Sbjct: 432 GAERTFVNIEGVQHVVILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFD 491

Query: 529 LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFG-DDKSSHMVPLQVQL----LAGED 365
             +V ++A    S A +++G  YAWG    G+LG G  D+   MV    ++    L G  
Sbjct: 492 SKIVGVSAKLATSIAWSEDGTAYAWGFDTTGQLGLGLKDEDEKMVSKPEEISSAHLDGYS 551

Query: 364 IVQVSCGGTHSVVL 323
           I+  S    H++++
Sbjct: 552 IIGASISDQHTLII 565



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 34/144 (23%), Positives = 57/144 (39%), Gaps = 19/144 (13%)
 Frame = -2

Query: 670 IAVGAFHNLALSVDRILWAWGNNEYGQLGI-------GDTQPRSQPIRV-------EGLS 533
           +    F  +    D   +A+G N Y QLGI       G     ++ +RV          +
Sbjct: 374 VFASGFWTIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQDNRELRVFLPAEAPAFGA 433

Query: 532 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFG-----DDKSSHMVPLQVQLLAGE 368
             + V+I  G  H   L  +G+V+A G+     LG G     DD+   +     ++    
Sbjct: 434 ERTFVNI-EGVQHVVILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFDS 492

Query: 367 DIVQVSCGGTHSVVLTSDGRIFSY 296
            IV VS     S+  + DG  +++
Sbjct: 493 KIVGVSAKLATSIAWSEDGTAYAW 516

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>FBX24_HUMAN (O75426) F-box only protein 24|
          Length = 580

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 4/81 (4%)
 Frame = -2

Query: 610 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEG----EVYAWGRGE 443
           GNN YGQLG GD   R +P +V  L     + +  G  HS  L++      E+   G G 
Sbjct: 382 GNNRYGQLGTGDKMDRGEPTQVCYLQR--PITLWCGLNHSLVLSQSSEFSKELLGCGCGA 439

Query: 442 HGRLGFGDDKSSHMVPLQVQL 380
            GRL      S+  V LQV++
Sbjct: 440 GGRLPGWPKGSASFVKLQVKV 460

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>FBX24_MOUSE (Q9D417) F-box only protein 24|
          Length = 589

 Score = 37.7 bits (86), Expect = 0.037
 Identities = 27/81 (33%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
 Frame = -2

Query: 610 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEG----EVYAWGRGE 443
           GNN YGQLG GD   R +P +V  L     + +  G  HS  L++      E+   G G 
Sbjct: 392 GNNRYGQLGTGDKMDRGEPTQVHYLQR--PIALWCGLNHSLVLSQTSDFSKELLGCGCGA 449

Query: 442 HGRLGFGDDKSSHMVPLQVQL 380
            GRL      S+  V L +++
Sbjct: 450 GGRLPGWPKGSASFVKLHIKV 470

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>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC|
           2.7.11.1)
          Length = 901

 Score = 35.8 bits (81), Expect = 0.14
 Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 509
           E VS ++ G+  N  L   +R ++ WG+      G+    PR          +L    I 
Sbjct: 160 EAVSTVSAGSVFNCGLFARNRTVFCWGDETVS--GVVGLAPR----------DLHFQSIG 207

Query: 508 AGGWHSAALTKEGEVYAWGR 449
           AGG+H   + +  +V+ WGR
Sbjct: 208 AGGYHVCGVLENAQVFCWGR 227

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>YB9W_YEAST (P38352) F-box protein YBR280C|
          Length = 637

 Score = 35.4 bits (80), Expect = 0.18
 Identities = 24/87 (27%), Positives = 41/87 (47%), Gaps = 19/87 (21%)
 Frame = -2

Query: 685 EQVSMIAVGAFHNLALSVDRILWAWG--NNEYGQLGIGDTQPRSQPIRV---EGLSNLSL 521
           E V  +A G +H +AL+    L++WG  + + G LG+G ++     + +   EG  N+ +
Sbjct: 546 ENVISVASGDYHTVALTERGHLYSWGIESQDCGCLGLGPSEKIVNELHIGNWEGQRNIRV 605

Query: 520 V--------------DIAAGGWHSAAL 482
           V               + AGGW + AL
Sbjct: 606 VKPTKIELPEDYICVSVTAGGWQTGAL 632



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 15/39 (38%), Positives = 26/39 (66%), Gaps = 2/39 (5%)
 Frame = -2

Query: 532 NLSLVDIAAGGWHSAALTKEGEVYAWG--RGEHGRLGFG 422
           N +++ +A+G +H+ ALT+ G +Y+WG    + G LG G
Sbjct: 545 NENVISVASGDYHTVALTERGHLYSWGIESQDCGCLGLG 583

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>POF9_SCHPO (O74381) F-box protein pof9|
          Length = 467

 Score = 34.7 bits (78), Expect = 0.31
 Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 19/85 (22%)
 Frame = -2

Query: 679 VSMIAVGAFHNLALSVDRILWAWG--NNEYGQLGIG---------DTQPRSQPIRVEGLS 533
           +  +A G  H+L L+ D  +W+WG      G LG+G         D    S P     + 
Sbjct: 339 IKQLAHGDHHHLYLTSDHSIWSWGVELRYCGCLGLGSLHLQEQTSDPSIVSDPRTARNIV 398

Query: 532 NL--------SLVDIAAGGWHSAAL 482
           ++        +   +AAGGW SAAL
Sbjct: 399 SIPHQIHFSGTCYSVAAGGWQSAAL 423



 Score = 30.4 bits (67), Expect = 5.9
 Identities = 24/88 (27%), Positives = 39/88 (44%), Gaps = 5/88 (5%)
 Frame = -2

Query: 700 RVQGLEQVSMIAVGAFHN-LALSVDR-ILWAWGN---NEYGQLGIGDTQPRSQPIRVEGL 536
           RVQGL  V  +    +    A+  DR   ++WG    N  G++   +  PR +P  + G 
Sbjct: 52  RVQGLTNVVPVVDDNYKRPYAVWKDRGYAYSWGQQIRNYLGRVVNTNQYPRDRPGALTGK 111

Query: 535 SNLSLVDIAAGGWHSAALTKEGEVYAWG 452
              S + +  GG+    L + G +Y  G
Sbjct: 112 DVRSTIQVQVGGYGMYLLNENGNLYVTG 139

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>UNC5B_HUMAN (Q8IZJ1) Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5|
           homolog 2) (p53-regulated receptor for death and life
           protein 1)
          Length = 945

 Score = 33.9 bits (76), Expect = 0.53
 Identities = 18/54 (33%), Positives = 25/54 (46%)
 Frame = +1

Query: 289 PSRKRISGRHWLAQLNGSLHMIPEQYPLQLEAEPVVAPCGCSYHPQSRASHVLL 450
           P    +S R W+ QL    H    +  + L+ E +  PC C   P  RA H+LL
Sbjct: 623 PHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPCYCQLEP--RACHILL 674

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>TKT_SCHPO (Q9URM2) Probable transketolase (EC 2.2.1.1) (TK)|
          Length = 685

 Score = 32.3 bits (72), Expect = 1.5
 Identities = 22/70 (31%), Positives = 31/70 (44%)
 Frame = -2

Query: 613 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 434
           +G  E+G  GI +      PI   G + L+ V  AAG    AAL     +Y      H  
Sbjct: 418 YGIREHGMAGIMNGLAVYGPIIPYGGTFLNFVSYAAGAVRMAALNNSRVIYV---ATHDS 474

Query: 433 LGFGDDKSSH 404
           +G G+D  +H
Sbjct: 475 IGLGEDGPTH 484

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>NAH_SCHPO (P36606) Na(+)/H(+) antiporter|
          Length = 468

 Score = 32.0 bits (71), Expect = 2.0
 Identities = 20/58 (34%), Positives = 28/58 (48%)
 Frame = +3

Query: 555 GCDLGWVSPIPSWPYSLLPHAHKILSTDSAKLWNAPTAIMLTCSSPCTRTGVDMFLIS 728
           GC +G++         +L HA K    D+   ++ P AI L CS   T  GVD  L+S
Sbjct: 220 GCVIGYLLSF------ILKHAQKYRLIDAISYYSLPLAIPLLCSGIGTIIGVDDLLMS 271

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>TIP_RAT (Q8R4E1) T-cell immunomodulatory protein precursor (Protein TIP)|
           (CDA08-like protein)
          Length = 610

 Score = 30.8 bits (68), Expect = 4.5
 Identities = 16/53 (30%), Positives = 31/53 (58%)
 Frame = +3

Query: 570 WVSPIPSWPYSLLPHAHKILSTDSAKLWNAPTAIMLTCSSPCTRTGVDMFLIS 728
           W + IP+    ++P+ H +  + SAKL+  P+ I+L   +    TGV +F+++
Sbjct: 531 WTAIIPNSQLMVIPYPHSVPRSWSAKLYLTPSNIVLL--TAVALTGVCVFILA 581


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 117,262,170
Number of Sequences: 219361
Number of extensions: 2671980
Number of successful extensions: 7282
Number of sequences better than 10.0: 55
Number of HSP's better than 10.0 without gapping: 6514
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6985
length of database: 80,573,946
effective HSP length: 109
effective length of database: 56,663,597
effective search space used: 7592921998
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

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full-length cDNA and EST

Clone Information

BLAST Search Result