ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | rbasdm19 |
|---|---|
| Clone Library Name | barley_pub |
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 109 bits (273), Expect = 7e-24 Identities = 66/171 (38%), Positives = 102/171 (59%), Gaps = 4/171 (2%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ Y H C+ +I+H D+K NILLD F + DFGLAKL + +T TA RGT+G Sbjct: 399 RGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVT-TAVRGTIG 457 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSD-PSVENQDEVYLPEWIYEKVIS 328 +IAPE S G S K+DV+ +G+++LE+++G+R D + N D+V L +W+ + ++ Sbjct: 458 HIAPEYLST--GKSSEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWV-KGLLK 514 Query: 327 GHDWELTLEMTAEDK---EKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTG 184 E +++ + E++ QL V L Q +P RP M++VV ML G Sbjct: 515 EKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVRMLEG 565
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 100 bits (248), Expect = 5e-21 Identities = 66/188 (35%), Positives = 102/188 (54%), Gaps = 10/188 (5%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ Y HQ RI+H D+K NILLD N PKISDFG+A++ RD++ GT G Sbjct: 636 RGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFGMARIFERDETEANTMKVVGTYG 695 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQD-EVYLPEWIYEKVIS 328 Y++PE +G S KSDV+SFG++VLE+VSG++N N D E L +++ + Sbjct: 696 YMSPEY--AMYGIFSEKSDVFSFGVIVLEIVSGKKNR--GFYNLDYENDLLSYVWSRWKE 751 Query: 327 GHDWE---------LTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQ 175 G E L+ + + +++++ +GL +Q ++RP+M+ VV M Sbjct: 752 GRALEIVDPVIVDSLSSQPSIFQPQEVLKCIQIGLLCVQELAEHRPAMSSVVWMFGSEAT 811 Query: 174 NLQIPPKP 151 + P P Sbjct: 812 EIPQPKPP 819
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 97.8 bits (242), Expect = 3e-20 Identities = 58/167 (34%), Positives = 94/167 (56%), Gaps = 2/167 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ + H G I+H DIK NILLD +F PK++DFGLA+L + +S ++ T GT G Sbjct: 1026 RGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLARLISACESHVS-TVIAGTFG 1084 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 YI PE Y ++ + K DVYSFG+++LE+V+G+ + P + + L W +K+ G Sbjct: 1085 YIPPE-YGQS-ARATTKGDVYSFGVILLELVTGKEPTGPDFKESEGGNLVGWAIQKINQG 1142 Query: 324 HDWEL--TLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNML 190 ++ L ++ K ++L + + + P RP+M V+ L Sbjct: 1143 KAVDVIDPLLVSVALKNSQLRLLQIAMLCLAETPAKRPNMLDVLKAL 1189
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 95.5 bits (236), Expect = 1e-19 Identities = 58/168 (34%), Positives = 102/168 (60%), Gaps = 4/168 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKL--CARDQSILTLTAARGTM 508 G+ Y H C I+H D+K NILLD ++ K++DFG+AK+ + ++ ++ G+ Sbjct: 803 GLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIAKVGQMSGSKTPEAMSGIAGSC 862 Query: 507 GYIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVI 331 GYIAPE +Y+ V+ KSD+YSFG+++LE+V+G++ +D + ++D + +W+ + Sbjct: 863 GYIAPEYVYTLR---VNEKSDIYSFGVVLLELVTGKQPTDSELGDKD---MAKWVCTALD 916 Query: 330 S-GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNML 190 G + + ++ + KE++ ++ +GL P NRPSM KVV ML Sbjct: 917 KCGLEPVIDPKLDLKFKEEISKVIHIGLLCTSPLPLNRPSMRKVVIML 964
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 94.7 bits (234), Expect = 2e-19 Identities = 50/108 (46%), Positives = 71/108 (65%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +G+ Y H C + ++H D+KP NILLD F PKI+DFGL KL R S ++ RGT+G Sbjct: 641 KGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFGLVKLLNRGGSTQNVSHVRGTLG 700 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVY 361 YIAPE S ++ K DVYS+G+++LE+++G R S+ V DEV+ Sbjct: 701 YIAPEWVSSL--PITAKVDVYSYGVVLLELLTGTRVSE-LVGGTDEVH 745
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 94.0 bits (232), Expect = 4e-19 Identities = 58/167 (34%), Positives = 97/167 (58%), Gaps = 2/167 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +G+ Y H+GC+ ILH DIK NILLD NFN ++DFGLA+L + ++ ++ T GT+G Sbjct: 843 KGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLADFGLARLMSPYETHVS-TDLVGTLG 901 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 YI PE + +YK DVYSFG+++LE+++ +R D + + L W+ + Sbjct: 902 YIPPEYGQASV--ATYKGDVYSFGVVLLELLTDKRPVD-MCKPKGCRDLISWVVKMKHES 958 Query: 324 HDWEL--TLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNML 190 E+ L + E+ ++M ++ + + NPK RP+ ++V+ L Sbjct: 959 RASEVFDPLIYSKENDKEMFRVLEIACLCLSENPKQRPTTQQLVSWL 1005
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 93.6 bits (231), Expect = 5e-19 Identities = 60/178 (33%), Positives = 94/178 (52%), Gaps = 2/178 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+EY H ++H DIK NIL+D + N +++DFGL+ L D GT+G Sbjct: 617 RGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSILGPADSGTPLSELPAGTLG 676 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 Y+ PE Y ++ ++ KSDVYSFG+++LE++SGR+ D E E + EW + +G Sbjct: 677 YLDPEYYRLHY--LTTKSDVYSFGVVLLEILSGRKAIDMQFE---EGNIVEWAVPLIKAG 731 Query: 324 HDWELTLEMTA--EDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQNLQIPP 157 + + + + D E + ++ V ++ K+RPSM KV L L L P Sbjct: 732 DIFAILDPVLSPPSDLEALKKIASVACKCVRMRGKDRPSMDKVTTALEHALALLMGSP 789
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 90.1 bits (222), Expect = 6e-18 Identities = 64/201 (31%), Positives = 109/201 (54%), Gaps = 11/201 (5%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ + H + +++ D K NILLD N++ K+SDFGLAKL D+ T GT G Sbjct: 202 RGLAFLHS-LQREVIYRDFKASNILLDSNYDAKLSDFGLAKLGPADEKSHVTTRIMGTYG 260 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 Y APE + G + KSDV++FG+++LE+++G + + + + L +W+ ++ + Sbjct: 261 YAAPEYMAT--GHLYVKSDVFAFGVVLLEIMTG-LTAHNTKRPRGQESLVDWLRPELSNK 317 Query: 324 H------DWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQNLQI 163 H D + + T + +M ++T L I+ +PKNRP M +VV +L +Q L + Sbjct: 318 HRVKQIMDKGIKGQYTTKVATEMARIT---LSCIEPDPKNRPHMKEVVEVLE-HIQGLNV 373 Query: 162 PP-----KPFVSSDNRPMPQN 115 P K V++ +R P + Sbjct: 374 VPNRSSTKQAVANSSRSSPHH 394
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 89.7 bits (221), Expect = 7e-18 Identities = 59/185 (31%), Positives = 99/185 (53%), Gaps = 8/185 (4%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +G+ Y H C+ ILH D+K +NILLD +F ++DFGLAK + +++ G+ G Sbjct: 800 KGLCYLHHDCSPLILHRDVKSNNILLDSDFEAHVADFGLAKFLVDGAASECMSSIAGSYG 859 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWI---YEKV 334 YIAPE Y+ V KSDVYSFG+++LE+++G++ P E + V + W+ E++ Sbjct: 860 YIAPE-YAYTL-KVDEKSDVYSFGVVLLELIAGKK---PVGEFGEGVDIVRWVRNTEEEI 914 Query: 333 ISGHDWELTL-----EMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQNL 169 D + + +T ++ + + + ++ RP+M +VV+MLT Sbjct: 915 TQPSDAAIVVAIVDPRLTGYPLTSVIHVFKIAMMCVEEEAAARPTMREVVHMLTN----- 969 Query: 168 QIPPK 154 PPK Sbjct: 970 --PPK 972
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 89.4 bits (220), Expect = 1e-17 Identities = 56/173 (32%), Positives = 93/173 (53%), Gaps = 8/173 (4%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ Y H C+ I+H DIKP NILLD + P ISDFG+AKL + + + +GT+GY Sbjct: 926 GLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIAKLLDQSATSIPSNTVQGTIGY 985 Query: 501 IAPELYSRNFGGV-SYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 +APE F V S +SDVYS+G+++LE+++ ++ DPS + ++ W+ Sbjct: 986 MAPE---NAFTTVKSRESDVYSYGVVLLELITRKKALDPSFNGETDIV--GWVRSVWTQT 1040 Query: 324 HDWELTLEMTAEDK-------EKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLT 187 + + ++ + D+ E++ + + L + RP+M VV LT Sbjct: 1041 GEIQKIVDPSLLDELIDSSVMEQVTEALSLALRCAEKEVDKRPTMRDVVKQLT 1093
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 89.4 bits (220), Expect = 1e-17 Identities = 56/175 (32%), Positives = 96/175 (54%), Gaps = 5/175 (2%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+EY H +Q +H D+KP NILL + K++DFGL +L + + T GT G Sbjct: 700 RGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAPEGKGSIE-TRIAGTFG 758 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 Y+APE G V+ K DVYSFG++++E+++GR++ D S + ++ ++L W I+ Sbjct: 759 YLAPEYAVT--GRVTTKVDVYSFGVILMELITGRKSLDES-QPEESIHLVSWFKRMYINK 815 Query: 324 H-DWELTLEMTAE-DKEKMMQLTIVGLWS---IQWNPKNRPSMTKVVNMLTGRLQ 175 ++ ++ T + D+E + + V + P RP M VN+L+ ++ Sbjct: 816 EASFKKAIDTTIDLDEETLASVHTVAELAGHCCAREPYQRPDMGHAVNILSSLVE 870
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 87.8 bits (216), Expect = 3e-17 Identities = 53/173 (30%), Positives = 92/173 (53%), Gaps = 3/173 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ + H C I+H D+K N+LLD +F ++SDFG+A+L + + L+++ GT G Sbjct: 968 RGLAFLHHSCIPHIIHRDMKSSNVLLDQDFVARVSDFGMARLVSALDTHLSVSTLAGTPG 1027 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 Y+ PE Y ++F + K DVYS+G+++LE++SG++ DP +D L W + Sbjct: 1028 YVPPEYY-QSF-RCTAKGDVYSYGVILLELLSGKKPIDPEEFGEDN-NLVGWAKQLYREK 1084 Query: 324 HDWELTLEMTAEDKE---KMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQ 175 E+ DK +++ + + P RP+M +V+ M +Q Sbjct: 1085 RGAEILDPELVTDKSGDVELLHYLKIASQCLDDRPFKRPTMIQVMTMFKELVQ 1137
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 87.4 bits (215), Expect = 4e-17 Identities = 55/166 (33%), Positives = 96/166 (57%), Gaps = 2/166 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ + H C+ I+H D+K N+LLD N ++SDFG+A+L + + L+++ GT G Sbjct: 992 RGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPG 1051 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSD-PSVENQDEV-YLPEWIYEKVI 331 Y+ PE Y ++F S K DVYS+G+++LE+++G+R +D P + + V ++ + ++ Sbjct: 1052 YVPPEYY-QSF-RCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRIS 1109 Query: 330 SGHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNM 193 D EL E A + E + L V + + RP+M +V+ M Sbjct: 1110 DVFDPELMKEDPALEIELLQHLK-VAVACLDDRAWRRPTMVQVMAM 1154
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 87.4 bits (215), Expect = 4e-17 Identities = 57/189 (30%), Positives = 94/189 (49%), Gaps = 3/189 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+EY H +++ D+K NILL ++ PK+SDFGLAK+ T GT G Sbjct: 213 RGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKVGPSGDKTHVSTRVMGTYG 272 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 Y AP+ Y+ G +++KSD+YSFG+++LE+++GR+ D + +D+ L W Sbjct: 273 YCAPD-YAMT-GQLTFKSDIYSFGVVLLELITGRKAIDNTKTRKDQ-NLVGWARPLFKDR 329 Query: 324 HDWELTLEMTAEDK---EKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQNLQIPPK 154 ++ ++ + + + Q + +Q P RP ++ VV L + P Sbjct: 330 RNFPKMVDPLLQGQYPVRGLYQALAISAMCVQEQPTMRPVVSDVVLALNFLASSKYDPNS 389 Query: 153 PFVSSDNRP 127 P SS P Sbjct: 390 PSSSSGKNP 398
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 87.4 bits (215), Expect = 4e-17 Identities = 57/166 (34%), Positives = 88/166 (53%), Gaps = 2/166 (1%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ Y HQ C ILH DIK NILL F ++DFGLA+L + +T T GT+GY Sbjct: 853 GLAYLHQSCEPHILHRDIKSSNILLSDTFVAHLADFGLARLILPYDTHVT-TDLVGTLGY 911 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH 322 I PE + +YK DVYSFG+++LE+++GRR D + + L W+ + Sbjct: 912 IPPEYGQASV--ATYKGDVYSFGVVLLELLTGRRPMD-VCKPRGSRDLISWVLQMKTEKR 968 Query: 321 DWEL--TLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNML 190 + E+ + E+M+ + + + NPK RP+ ++V+ L Sbjct: 969 ESEIFDPFIYDKDHAEEMLLVLEIACRCLGENPKTRPTTQQLVSWL 1014
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 86.3 bits (212), Expect = 8e-17 Identities = 45/106 (42%), Positives = 66/106 (62%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +G+E+ H N +++ D K NILLD F+PK+SDFGLAKL T GT G Sbjct: 196 KGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLGPTGDKSHVSTRVMGTYG 255 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDE 367 Y APE Y+ G ++ KSDVYSFG++ LE+++GR+ D + + ++ Sbjct: 256 YCAPE-YAMT-GQLTVKSDVYSFGVVFLELITGRKAIDSEMPHGEQ 299
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 85.9 bits (211), Expect = 1e-16 Identities = 41/105 (39%), Positives = 69/105 (65%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ + H C I+H D+K N+LLD +F ++SDFG+A+L + + L+++ GT G Sbjct: 970 RGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMARLVSALDTHLSVSTLAGTPG 1029 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQD 370 Y+ PE Y ++F + K DVYS+G+++LE++SG++ DP +D Sbjct: 1030 YVPPEYY-QSF-RCTAKGDVYSYGVILLELLSGKKPIDPGEFGED 1072
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 85.5 bits (210), Expect = 1e-16 Identities = 55/168 (32%), Positives = 92/168 (54%), Gaps = 3/168 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ + H Q +++ D K NILLD N+N K+SDFGLA+ + T GT G Sbjct: 187 RGLAFLHNAQPQ-VIYRDFKASNILLDSNYNAKLSDFGLARDGPMGDNSHVSTRVMGTQG 245 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 Y APE + G +S KSDVYSFG+++LE++SGRR D + + E L +W + + Sbjct: 246 YAAPEYLAT--GHLSVKSDVYSFGVVLLELLSGRRAIDKN-QPVGEHNLVDWARPYLTNK 302 Query: 324 HDWELTLEMTAEDK---EKMMQLTIVGLWSIQWNPKNRPSMTKVVNML 190 ++ + + + +++ ++ L I + K+RP+M ++V + Sbjct: 303 RRLLRVMDPRLQGQYSLTRALKIAVLALDCISIDAKSRPTMNEIVKTM 350
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 84.0 bits (206), Expect = 4e-16 Identities = 57/168 (33%), Positives = 90/168 (53%), Gaps = 3/168 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +G+ + H R+++ D K NILLD +N K+SDFGLAK T GT G Sbjct: 187 KGLAFLHSS-ETRVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPIGDKSHVSTRVMGTHG 245 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 Y APE + G ++ KSDVYSFG+++LE++SGRR D + E L EW +++ Sbjct: 246 YAAPEYLAT--GHLTTKSDVYSFGVVLLELLSGRRAVDKN-RPSGERNLVEWAKPYLVNK 302 Query: 324 HDWELTLEMTAEDK---EKMMQLTIVGLWSIQWNPKNRPSMTKVVNML 190 ++ +D+ E+ ++ + L + K RP+M++VV+ L Sbjct: 303 RKIFRVIDNRLQDQYSMEEACKVATLSLRCLTTEIKLRPNMSEVVSHL 350
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 83.6 bits (205), Expect = 5e-16 Identities = 55/170 (32%), Positives = 93/170 (54%), Gaps = 6/170 (3%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ + H C I+H D+K N+LLD N ++SDFG+A+L + + L+++ GT G Sbjct: 997 RGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPG 1056 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWI----YEK 337 Y+ PE Y ++F S K DVYS+G+++LE+++G++ +D + + L W+ K Sbjct: 1057 YVPPEYY-QSF-RCSTKGDVYSYGVVLLELLTGKQPTDSADFGDNN--LVGWVKLHAKGK 1112 Query: 336 VISGHDWELTLEMTAEDKEKMMQLTI--VGLWSIQWNPKNRPSMTKVVNM 193 + D EL E + + E + L + L W RP+M +V+ M Sbjct: 1113 ITDVFDRELLKEDASIEIELLQHLKVACACLDDRHW---KRPTMIQVMAM 1159
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 83.6 bits (205), Expect = 5e-16 Identities = 55/170 (32%), Positives = 93/170 (54%), Gaps = 6/170 (3%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ + H C I+H D+K N+LLD N ++SDFG+A+L + + L+++ GT G Sbjct: 997 RGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPG 1056 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWI----YEK 337 Y+ PE Y ++F S K DVYS+G+++LE+++G++ +D + + L W+ K Sbjct: 1057 YVPPEYY-QSF-RCSTKGDVYSYGVVLLELLTGKQPTDSADFGDNN--LVGWVKLHAKGK 1112 Query: 336 VISGHDWELTLEMTAEDKEKMMQLTI--VGLWSIQWNPKNRPSMTKVVNM 193 + D EL E + + E + L + L W RP+M +V+ M Sbjct: 1113 ITDVFDRELLKEDASIEIELLQHLKVACACLDDRHW---KRPTMIQVMAM 1159
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 83.2 bits (204), Expect = 7e-16 Identities = 58/182 (31%), Positives = 97/182 (53%), Gaps = 17/182 (9%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +G+ + H C I+H D+K N+LLD + ++SDFG+A+L + + L+++ GT G Sbjct: 949 KGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGMARLISALDTHLSVSTLAGTPG 1008 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 Y+ PE Y ++F + K DVYS G+++LE++SG+R +D E + L W K G Sbjct: 1009 YVPPEYY-QSF-RCTAKGDVYSIGVVMLEILSGKRPTDK--EEFGDTNLVGWSKMKAREG 1064 Query: 324 H-----DWELTLEMTAE---DKE---------KMMQLTIVGLWSIQWNPKNRPSMTKVVN 196 D +L E ++E +KE +M++ + L + P RP+M +VV Sbjct: 1065 KHMEVIDEDLLKEGSSESLNEKEGFEGGVIVKEMLRYLEIALRCVDDFPSKRPNMLQVVA 1124 Query: 195 ML 190 L Sbjct: 1125 SL 1126
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 83.2 bits (204), Expect = 7e-16 Identities = 50/166 (30%), Positives = 94/166 (56%), Gaps = 4/166 (2%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +G+EY H GC I+H D+KP NILL+ K++DFGL++ + + S T G++G Sbjct: 680 QGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLSRSFSVEGSGQISTVVAGSIG 739 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQ--DEVYLPEWIYEKVI 331 Y+ PE YS ++ KSDVYS G+++LE+++G+ P++ + ++V++ + + + Sbjct: 740 YLDPEYYSTR--QMNEKSDVYSLGVVLLEVITGQ----PAIASSKTEKVHISDHVRSILA 793 Query: 330 SGHDWELTLEMTAE--DKEKMMQLTIVGLWSIQWNPKNRPSMTKVV 199 +G + + E D +++ + L + RP+M++VV Sbjct: 794 NGDIRGIVDQRLRERYDVGSAWKMSEIALACTEHTSAQRPTMSQVV 839
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 81.3 bits (199), Expect = 3e-15 Identities = 54/166 (32%), Positives = 88/166 (53%), Gaps = 4/166 (2%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARD-QSILTLTAARGTM 508 RG+ + H ++H DIKP NILLD PKI DFGL + + +++ + GT Sbjct: 329 RGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLDAVVEVNKVFGTK 388 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 Y+ PE RNF +S DVYSFG+++LE+ +GR+ +D EN+ + L +++ ++ Sbjct: 389 IYLPPEF--RNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKNLLDYVKQQWRQ 446 Query: 327 GHDWELTLEMTA---EDKEKMMQLTIVGLWSIQWNPKNRPSMTKVV 199 L + A ++ + M GL +P++RPSM V+ Sbjct: 447 NRMELLEKHLAAPMGKELDMCMCAIEAGLHCTALDPQDRPSMNAVL 492
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 80.5 bits (197), Expect = 4e-15 Identities = 55/168 (32%), Positives = 88/168 (52%), Gaps = 3/168 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +G+ + H +++ D K NILLD +N K+SDFGLAK T GT G Sbjct: 188 KGLAFLHNA-ETSVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPTGDKSHVSTRIMGTYG 246 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 Y APE + G ++ KSDVYS+G+++LE++SGRR D + E L EW + + Sbjct: 247 YAAPEYLAT--GHLTTKSDVYSYGVVLLEVLSGRRAVDKN-RPPGEQKLVEWARPLLANK 303 Query: 324 HDWELTLEMTAEDK---EKMMQLTIVGLWSIQWNPKNRPSMTKVVNML 190 ++ +D+ E+ ++ + L + + K RP+M +VV+ L Sbjct: 304 RKLFRVIDNRLQDQYSMEEACKVATLALRCLTFEIKLRPNMNEVVSHL 351
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 78.6 bits (192), Expect = 2e-14 Identities = 39/94 (41%), Positives = 58/94 (61%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ Y H + ++H D+K NILLD++ K++DFG +K ++ RGT G Sbjct: 704 RGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKVADFGFSKYAPQEGDSYVSLEVRGTAG 763 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y+ PE Y +S KSDV+SFG+++LE+VSGR Sbjct: 764 YLDPEYYKTQ--QLSEKSDVFSFGVVLLEIVSGR 795
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does| not make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 77.4 bits (189), Expect = 4e-14 Identities = 39/94 (41%), Positives = 57/94 (60%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ Y H + ++H D+K NILLD + K++DFG +K ++ RGT G Sbjct: 705 RGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKYAPQEGDSYVSLEVRGTAG 764 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y+ PE Y +S KSDV+SFG+++LE+VSGR Sbjct: 765 YLDPEYYKTQ--QLSEKSDVFSFGVVLLEIVSGR 796
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 75.9 bits (185), Expect = 1e-13 Identities = 55/166 (33%), Positives = 85/166 (51%), Gaps = 2/166 (1%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ + H+ + +H DIK NILLD +F KISDFGLA+ AR + + GT Y Sbjct: 298 GIRFLHENHH---IHRDIKSANILLDKDFTAKISDFGLARASARLAQTVMTSRIVGTTAY 354 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWI--YEKVIS 328 +APE G ++ KSD+YSFG+++LE+++G D + E Q + + E I EK I Sbjct: 355 MAPEALR---GEITPKSDIYSFGVVLLELITGLAAVDENREPQLLLDIKEEIEDEEKTIE 411 Query: 327 GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNML 190 + E +M+ D + + + RP + KV +L Sbjct: 412 DYTDE---KMSDADPASVEAMYSAASQCLHEKKNRRPDIAKVQQLL 454
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 74.3 bits (181), Expect = 3e-13 Identities = 53/158 (33%), Positives = 77/158 (48%), Gaps = 2/158 (1%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y H N +LH D+KP N+L D + K++DFGL+ QS GT+GY Sbjct: 127 GMFYLHDQ-NPVLLHRDLKPSNVLPDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGY 185 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH 322 +APEL+ S SDVYSFG+L+ +++GR P+ P +YE V + Sbjct: 186 LAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTE--------PSLVYEAVCNRQ 237 Query: 321 DWELTLEMTAEDKEKMMQLTIVGLWSIQWN--PKNRPS 214 + E+ E + L + W+ PK+RPS Sbjct: 238 NRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPS 275
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 72.8 bits (177), Expect = 9e-13 Identities = 55/170 (32%), Positives = 84/170 (49%), Gaps = 6/170 (3%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ + H+ + +H DIK NILLD F KISDFGLA+ + + + GT Y Sbjct: 298 GINFLHENHH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAY 354 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH 322 +APE G ++ KSD+YSFG+++LE+++G P+V+ E L I E++ Sbjct: 355 MAPEALR---GEITPKSDIYSFGVVLLEIITGL----PAVDEHREPQLLLDIKEEI---E 404 Query: 321 DWELTLE------MTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNML 190 D E T+E M D + + V + RP + KV +L Sbjct: 405 DEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLL 454
>CHK1_YEAST (P38147) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 527 Score = 71.2 bits (173), Expect = 3e-12 Identities = 42/111 (37%), Positives = 66/111 (59%), Gaps = 2/111 (1%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTA-ARGTMGY 502 + Y H C + H DIKP NILLD N N K++DFGLA R L ++ RG+ Y Sbjct: 129 INYLHVECG--VAHRDIKPENILLDKNGNLKLADFGLASQFRRKDGTLRVSMDQRGSPPY 186 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSD-PSVENQDEVYLPE 352 +APE+ G + ++D++S G+L+ +++G+ + PS+EN+D V+ E Sbjct: 187 MAPEVLYSEEGYYADRTDIWSIGILLFVLLTGQTPWELPSLENEDFVFFIE 237
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 68.9 bits (167), Expect = 1e-11 Identities = 42/95 (44%), Positives = 57/95 (60%), Gaps = 2/95 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTA--ARGTM 508 GM Y H N +LH D+KP N+LLD + K++DFGL+ QS + + GT+ Sbjct: 128 GMCYLHS-LNPSLLHRDLKPSNVLLDLELHAKLADFGLSTFQGGSQSGSGSGSRDSGGTL 186 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y+APEL N G S SDVYSFG+LV +++GR Sbjct: 187 AYLAPELLD-NDGKASKASDVYSFGVLVWTVLAGR 220
>CDC5_YEAST (P32562) Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC| 2.7.11.21) Length = 705 Score = 68.6 bits (166), Expect = 2e-11 Identities = 48/161 (29%), Positives = 84/161 (52%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 ++Y H ++R++H D+K NI D N+N KI DFGLA + A + GT YI Sbjct: 192 IKYMH---SRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESE--RKYTICGTPNYI 246 Query: 498 APELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGHD 319 APE+ G S++ D++S G+++ ++ G+ P + +D IYE+ I D Sbjct: 247 APEVLMGKHSGHSFEVDIWSLGVMLYALLIGK----PPFQARD----VNTIYER-IKCRD 297 Query: 318 WELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVN 196 + + D+ K++ I+ L +P RPS+T++++ Sbjct: 298 FSFPRDKPISDEGKILIRDILSL-----DPIERPSLTEIMD 333
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 68.2 bits (165), Expect = 2e-11 Identities = 34/84 (40%), Positives = 54/84 (64%), Gaps = 2/84 (2%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLC--ARDQSILTLTAARGTMGYIAPELYSRNF 472 +LH D+KP NILLD N + KISDFGL+K + + + +A RGT+ YI PE++ N Sbjct: 153 LLHLDLKPGNILLDNNMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYIPPEMFLENN 212 Query: 471 GGVSYKSDVYSFGMLVLEMVSGRR 400 + DVYSF +++ E+++ ++ Sbjct: 213 KAPGPEYDVYSFAIVIWEILTQKK 236
>ST32A_HUMAN (Q8WU08) Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1)| Length = 396 Score = 67.8 bits (164), Expect = 3e-11 Identities = 37/86 (43%), Positives = 54/86 (62%), Gaps = 1/86 (1%) Frame = -2 Query: 654 NQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELY-SR 478 NQRI+H D+KP NILLD + + I+DF +A + R+ I T+ GT Y+APE++ SR Sbjct: 139 NQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMA---GTKPYMAPEMFSSR 195 Query: 477 NFGGVSYKSDVYSFGMLVLEMVSGRR 400 G S+ D +S G+ E++ GRR Sbjct: 196 KGAGYSFAVDWWSLGVTAYELLRGRR 221
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 66.6 bits (161), Expect = 7e-11 Identities = 52/175 (29%), Positives = 88/175 (50%), Gaps = 13/175 (7%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNP-------------KISDFGLAKLCARDQ 544 +GM Y H G ILH D+ NILLD+N +P KISDFGL++L + + Sbjct: 1401 KGMNYLH-GWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRL--KKE 1457 Query: 543 SILTLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 +T + G + Y+APE++ + S KSDVYS+GM++ E+++ S E Q ++ Sbjct: 1458 QASQMTQSVGCIPYMAPEVFKGDSN--SEKSDVYSYGMVLFELLT-------SDEPQQDM 1508 Query: 363 YLPEWIYEKVISGHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVV 199 + + + + L +++ KE + Q W NP +RP+ +++ Sbjct: 1509 KPMKMAHLAAYESYRPPIPLTTSSKWKEILTQ-----CWDS--NPDSRPTFKQII 1556
>CHK1_SCHPO (P34208) Serine/threonine-protein kinase chk1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 496 Score = 65.9 bits (159), Expect = 1e-10 Identities = 43/124 (34%), Positives = 65/124 (52%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ + H ++ + H D+KP NILLDYN N KISDFG A L + L + G+ Y Sbjct: 124 GISFMH---SKGVAHRDLKPENILLDYNGNLKISDFGFASLFSYKGKSRLLNSPVGSPPY 180 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH 322 APE+ + G K DV+S G+++ ++ G D ++ N + L + E+ S H Sbjct: 181 AAPEITQQYDGS---KVDVWSCGIILFALLLGNTPWDEAISNTGDYLLYKKQCERP-SYH 236 Query: 321 DWEL 310 W L Sbjct: 237 PWNL 240
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 65.5 bits (158), Expect = 1e-10 Identities = 33/84 (39%), Positives = 52/84 (61%), Gaps = 2/84 (2%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARD--QSILTLTAARGTMGYIAPELYSRNF 472 +LH D+KP NILLD N + KISDFGL+K + + +A RG + YI PE++ + Sbjct: 141 LLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSALRGMLSYIPPEMFLESN 200 Query: 471 GGVSYKSDVYSFGMLVLEMVSGRR 400 K DVYSF +++ E+++ ++ Sbjct: 201 KAPGPKYDVYSFAIVIWELLTQKK 224
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 64.3 bits (155), Expect = 3e-10 Identities = 36/85 (42%), Positives = 54/85 (63%), Gaps = 1/85 (1%) Frame = -2 Query: 657 CNQR-ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYS 481 C+ R + H D+KP N+LLD + N KISDFGL+ L + L GT Y+APE+ S Sbjct: 125 CHSRGVCHRDLKPENLLLDEHGNLKISDFGLSALSDSRRQDGLLHTTCGTPAYVAPEVIS 184 Query: 480 RNFGGVSYKSDVYSFGMLVLEMVSG 406 RN G +K+DV+S G+++ +++G Sbjct: 185 RN-GYDGFKADVWSCGVILFVLLAG 208
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 63.9 bits (154), Expect = 4e-10 Identities = 34/102 (33%), Positives = 61/102 (59%), Gaps = 7/102 (6%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKL-------CARDQSILTLT 526 R +++ HQ + ++H DIK N+LLD PK+ DFGLA+ ++ ++ + Sbjct: 324 RAIQFLHQD-SPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTS 382 Query: 525 AARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 400 RGT+ Y+ PE Y + G ++ +D +SFG+++LE ++G+R Sbjct: 383 TVRGTLAYL-PEEYIKT-GRLAVDTDTFSFGVVILETLAGQR 422
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 63.5 bits (153), Expect = 6e-10 Identities = 35/94 (37%), Positives = 58/94 (61%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ Y H ++ I+H D+K N+L+D++ KISDFG++K + +G++ + Sbjct: 942 GLSYLH---SKGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANLSMQGSIFW 998 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 400 +APE+ + G S K DV+S G +VLEM++GRR Sbjct: 999 MAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRR 1032
>PLO1_SCHPO (P50528) Serine/threonine-protein kinase plo1 (EC 2.7.11.21)| Length = 683 Score = 63.5 bits (153), Expect = 6e-10 Identities = 46/162 (28%), Positives = 88/162 (54%), Gaps = 1/162 (0%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 ++Y H+ +R++H D+K NI+LD + N KI DFGLA L D+ GT YI Sbjct: 151 LKYMHK---KRVIHRDLKLGNIMLDESNNVKIGDFGLAALLMDDEE--RKMTICGTPNYI 205 Query: 498 APELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKV-ISGH 322 APE+ + G S++ D++S G+++ ++ G+ P ++++ + IY K+ + + Sbjct: 206 APEILFNSKEGHSFEVDLWSAGVVMYALLIGK----PPFQDKE----VKTIYRKIKANSY 257 Query: 321 DWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVN 196 + ++++AE K+ + L + +P RPS+ +V+ Sbjct: 258 SFPSNVDISAEAKDLISSL-------LTHDPSIRPSIDDIVD 292
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 63.2 bits (152), Expect = 7e-10 Identities = 40/129 (31%), Positives = 71/129 (55%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ Y H G I+H +I+ N+L+D F ++++FGL K+ + + ++ A+ G Sbjct: 483 RGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGLDKIMVQAVADEIVSQAKSD-G 541 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 Y APEL+ + +SDVY+FG+L+LE++ G++ + V LP + V+ Sbjct: 542 YKAPELHKMK--KCNPRSDVYAFGILLLEILMGKKPGKSGRNGNEFVDLPSLVKAAVLE- 598 Query: 324 HDWELTLEM 298 E T+E+ Sbjct: 599 ---ETTMEV 604
>ST32A_MOUSE (Q8BGW6) Serine/threonine-protein kinase 32A (EC 2.7.11.1)| Length = 398 Score = 63.2 bits (152), Expect = 7e-10 Identities = 35/86 (40%), Positives = 54/86 (62%), Gaps = 1/86 (1%) Frame = -2 Query: 654 NQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELY-SR 478 +QRI+H D+KP NILLD + + I+DF +A + ++ I T+ GT Y+APE++ SR Sbjct: 139 SQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPKETRITTVA---GTKPYMAPEMFTSR 195 Query: 477 NFGGVSYKSDVYSFGMLVLEMVSGRR 400 G S+ D +S G+ E++ GRR Sbjct: 196 KETGYSFAVDWWSLGVTAYELLRGRR 221
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 63.2 bits (152), Expect = 7e-10 Identities = 35/102 (34%), Positives = 59/102 (57%), Gaps = 7/102 (6%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLC-------ARDQSILTLT 526 R +++ HQ + ++H DIK N+LLD PK+ DFGLA+ ++ + Sbjct: 324 RAIQFLHQD-SPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQ 382 Query: 525 AARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 400 RGT+ Y+ PE Y + G ++ +D +SFG++VLE ++G+R Sbjct: 383 TVRGTLAYL-PEEYIKT-GRLAVDTDTFSFGVVVLETLAGQR 422
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 62.8 bits (151), Expect = 1e-09 Identities = 41/112 (36%), Positives = 63/112 (56%), Gaps = 8/112 (7%) Frame = -2 Query: 657 CNQR-ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYS 481 C+ R + H D+KP N+L+D N N K+SDFGL+ L + + L GT Y+APE+ S Sbjct: 136 CHARGVYHRDLKPENLLIDENGNLKVSDFGLSALTDQIRPDGLLHTLCGTPAYVAPEILS 195 Query: 480 RNFGGVSYKSDVYSFGMLVLEMVSGRRN-SDPSVEN------QDEVYLPEWI 346 + G K DV+S G+++ +V+G +DP+V N + E P W+ Sbjct: 196 KK-GYEGAKVDVWSCGIVLFVLVAGYLPFNDPNVMNMYKKIYKGEYRFPRWM 246
>CHK1_USTMA (P0C198) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 662 Score = 62.8 bits (151), Expect = 1e-09 Identities = 39/105 (37%), Positives = 55/105 (52%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+EY H +Q + H DIKP N+LLD N KI+DFGL + LT A G++ Y Sbjct: 180 GLEYIH---SQGVTHRDIKPENMLLDAEGNLKIADFGLCSVYKYKGKERELTGACGSLPY 236 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDE 367 IAPE+ + + G DV+S G+++ M+ G D E Sbjct: 237 IAPEMNGKPYRGEPV--DVWSSGVVLFAMLVGSTPWDEPTSRSPE 279
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 62.8 bits (151), Expect = 1e-09 Identities = 39/95 (41%), Positives = 60/95 (63%), Gaps = 2/95 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G++Y H N I+H DIKP NIL+D +FN KI+DFG A++ D + +T GT + Sbjct: 1472 GIDYLHSS-NPMIVHRDIKPANILVDEHFNVKIADFGFARI-KEDNTTMTRC---GTPCW 1526 Query: 501 IAPELYSRNFGGVSY--KSDVYSFGMLVLEMVSGR 403 APE+ G Y K+DV+SFG+++ E+++G+ Sbjct: 1527 TAPEV----IRGEKYCEKADVFSFGVVMWEVLTGK 1557 Score = 58.2 bits (139), Expect = 2e-08 Identities = 33/92 (35%), Positives = 55/92 (59%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM + H + I+H D+K N+LLD +N K+SDFGL K+ + T GT+ Sbjct: 894 KGMHFLH---SSGIVHRDLKSLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIH 950 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 409 +IAPE+ + + +DVYSFG+++ E+++ Sbjct: 951 WIAPEILNDSTEVDYILADVYSFGIILWELLT 982
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 62.4 bits (150), Expect = 1e-09 Identities = 40/113 (35%), Positives = 63/113 (55%), Gaps = 1/113 (0%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQS-ILTLTAARGTMGYIAPELYSRNFG 469 +LH D+KP NILLD +++ KISDFGLAK S L++ GT+ Y+ PE Sbjct: 139 LLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSR 198 Query: 468 GVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGHDWEL 310 K DVYSF +++ +++ ++ P + ++ ++ I KV+ GH EL Sbjct: 199 LFDTKHDVYSFAIVIWGVLTQKK---PFADEKNILH----IMVKVVKGHRPEL 244
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 62.0 bits (149), Expect = 2e-09 Identities = 33/90 (36%), Positives = 57/90 (63%) Frame = -2 Query: 672 YXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAP 493 + HQ +I+H DIKPHNIL+D+ N K++DFG+A + +I + G++ Y++P Sbjct: 124 HAHQN---QIVHRDIKPHNILIDHMGNIKVTDFGIATALS-STTITHTNSVLGSVHYLSP 179 Query: 492 ELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 E G + KSD+Y+ G+++ E+++GR Sbjct: 180 E--QARGGLATKKSDIYALGIVLFELLTGR 207
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 61.6 bits (148), Expect = 2e-09 Identities = 55/165 (33%), Positives = 80/165 (48%), Gaps = 6/165 (3%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAK--LCARDQSILTLTAAR-GT 511 G+ Y H N +LH D+K NILLD F+ KI+DFGL+K + + QS +A GT Sbjct: 131 GVNYLHN-MNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGT 189 Query: 510 MGYIAPELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKV 334 + Y+ PE Y S K D+YS+ +++ E++S + + +EV P I V Sbjct: 190 IIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRK-------QPFEEVTNPLQIMYSV 242 Query: 333 ISGHDWELTLEMTAED--KEKMMQLTIVGLWSIQWNPKNRPSMTK 205 GH + + E D +M I W+ NP RPS K Sbjct: 243 SQGHRPDTSEENLPFDIPHRGLMISLIQSGWA--QNPDERPSFLK 285
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 61.2 bits (147), Expect = 3e-09 Identities = 36/93 (38%), Positives = 56/93 (60%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+EY H N I+H DIK NIL+D K++DFG +K A +I + +GT + Sbjct: 183 GLEYLH---NHAIMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGTPYW 239 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 +APE+ + G S+ +D++S G V+EMV+G+ Sbjct: 240 MAPEVILQT--GHSFSADIWSVGCTVIEMVTGK 270
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 61.2 bits (147), Expect = 3e-09 Identities = 48/179 (26%), Positives = 89/179 (49%), Gaps = 3/179 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM Y H N I+H D+K N+L+D + K+ DFGL++L A + L+ +A GT Sbjct: 660 KGMNYLHNR-NPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKA--STFLSSKSAAGTPE 716 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR---NSDPSVENQDEVYLPEWIYEKV 334 ++APE+ + KSDVYSFG+++ E+ + ++ N +P+ +V Sbjct: 717 WMAPEVLRDE--PSNEKSDVYSFGVILWELATLQQPWGNLNPA---------------QV 759 Query: 333 ISGHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQNLQIPP 157 ++ ++ + + I G W+ + P RPS ++++L +++ PP Sbjct: 760 VAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNE--PWKRPSFATIMDLLRPLIKSAVPPP 816
>TSSK1_MOUSE (Q61241) Testis-specific serine/threonine-protein kinase 1 (EC| 2.7.11.1) (TSSK-1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A) Length = 364 Score = 61.2 bits (147), Expect = 3e-09 Identities = 44/139 (31%), Positives = 70/139 (50%), Gaps = 12/139 (8%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQS---ILTLTAARGTMGYIAPELYSRN 475 ++H D+K N+LLD +FN K+SDFG +K C RD S IL+ T G+ Y APE+ Sbjct: 132 VVHRDLKSENLLLDKDFNIKLSDFGFSKRCLRDDSGRLILSKTFC-GSAAYAAPEVLQ-- 188 Query: 474 FGGVSYKS---DVYSFGMLVLEMVSGRRNSDPS------VENQDEVYLPEWIYEKVISGH 322 G+ Y+ D++S G+++ MV G D S ++ + V P K ++G Sbjct: 189 --GIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKLRIQKEHRVNFPR---SKHLTGE 243 Query: 321 DWELTLEMTAEDKEKMMQL 265 +L M D + + + Sbjct: 244 CKDLIYRMLQPDVNRRLHI 262
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 60.8 bits (146), Expect = 4e-09 Identities = 38/85 (44%), Positives = 52/85 (61%), Gaps = 4/85 (4%) Frame = -2 Query: 651 QRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRN 475 Q + H DIKP NIL+ +F+ KISDFGLAK+ + L GTMGY+APE L S+N Sbjct: 288 QGVTHRDIKPENILITNDFHLKISDFGLAKVIHGTGTFLETFC--GTMGYLAPEVLKSKN 345 Query: 474 F---GGVSYKSDVYSFGMLVLEMVS 409 GG K D++S G ++ M++ Sbjct: 346 VNLDGGYDDKVDIWSLGCVLYVMLT 370
>RIPK3_MOUSE (Q9QZL0) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) Length = 486 Score = 60.5 bits (145), Expect = 5e-09 Identities = 39/97 (40%), Positives = 55/97 (56%), Gaps = 4/97 (4%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTA----ARG 514 GM Y H + +LH D+KP NILLD + K++DFGL+ QS + + G Sbjct: 128 GMCYLHS-LDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGG 186 Query: 513 TMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 T+ Y+ PEL + S SDVYSFG+LV +++GR Sbjct: 187 TLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 60.5 bits (145), Expect = 5e-09 Identities = 35/93 (37%), Positives = 56/93 (60%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+EY H N I+H DIK NIL+D K++DFG +K A ++ + +GT + Sbjct: 184 GLEYLH---NHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYW 240 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 +APE+ + G S+ +D++S G V+EMV+G+ Sbjct: 241 MAPEVILQT--GHSFSADIWSVGCTVIEMVTGK 271
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 60.5 bits (145), Expect = 5e-09 Identities = 54/166 (32%), Positives = 81/166 (48%), Gaps = 7/166 (4%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAK--LCARDQSILTLTAAR-GT 511 G+ Y H +LH D+K NILLD F+ KI+DFGL+K + + QS + +A GT Sbjct: 131 GVNYLHN-MTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGT 189 Query: 510 MGYIAPELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKV 334 + Y+ PE Y S K D+YS+ ++ E++S + + ++V P I V Sbjct: 190 IIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRK-------QPFEDVTNPLQIMYSV 242 Query: 333 ISGHDWELTLEMTAED---KEKMMQLTIVGLWSIQWNPKNRPSMTK 205 GH + E D + +M+ L G W+ NP RPS K Sbjct: 243 SQGHRPVINEESLPYDIPHRARMISLIESG-WA--QNPDERPSFLK 285
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 60.5 bits (145), Expect = 5e-09 Identities = 38/95 (40%), Positives = 58/95 (61%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +G+ Y H ++ ILH D+K N+LLD + KISDFG+++ S +T RGT+ Sbjct: 1289 KGLAYLH---SKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMT-MRGTVF 1344 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR 400 ++APE+ G S K D++S G +VLEM +G+R Sbjct: 1345 WMAPEMVDTK-QGYSAKVDIWSLGCIVLEMFAGKR 1378
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 59.7 bits (143), Expect = 8e-09 Identities = 32/84 (38%), Positives = 51/84 (60%) Frame = -2 Query: 654 NQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRN 475 + RILH D+KP N+LLD N + K+ DFGLA+ + LT+ +GT Y+APEL + Sbjct: 118 SNRILHRDLKPQNVLLDKNMHAKLCDFGLARNMTLGTHV--LTSIKGTPLYMAPELLAEQ 175 Query: 474 FGGVSYKSDVYSFGMLVLEMVSGR 403 + +D++S G + E ++G+ Sbjct: 176 --PYDHHADMWSLGCIAYESMAGQ 197
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 59.7 bits (143), Expect = 8e-09 Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 1/184 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAA-RGTM 508 + + + HQ I+H D+KP NI++ K+ DFG+A+ A + +T TAA GT Sbjct: 124 QALNFSHQN---GIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA 180 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 Y++PE V +SDVYS G ++ E+++G +P V V Sbjct: 181 QYLSPE--QARGDSVDARSDVYSLGCVLYEVLTG----EPPFTGDSPV--------SVAY 226 Query: 327 GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQNLQIPPKPF 148 H E + +A + L V L ++ NP+NR + R+ N + P P Sbjct: 227 QHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPK 286 Query: 147 VSSD 136 V +D Sbjct: 287 VLTD 290
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 59.7 bits (143), Expect = 8e-09 Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 1/184 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAA-RGTM 508 + + + HQ I+H D+KP NI++ K+ DFG+A+ A + +T TAA GT Sbjct: 124 QALNFSHQN---GIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA 180 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 Y++PE V +SDVYS G ++ E+++G +P V V Sbjct: 181 QYLSPE--QARGDSVDARSDVYSLGCVLYEVLTG----EPPFTGDSPV--------SVAY 226 Query: 327 GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQNLQIPPKPF 148 H E + +A + L V L ++ NP+NR + R+ N + P P Sbjct: 227 QHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPK 286 Query: 147 VSSD 136 V +D Sbjct: 287 VLTD 290
>GPRK1_DROME (P32865) G protein-coupled receptor kinase 1 (EC 2.7.11.16)| Length = 700 Score = 59.7 bits (143), Expect = 8e-09 Identities = 41/94 (43%), Positives = 59/94 (62%), Gaps = 2/94 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+E+ H+ C I++ D+KP NILLD N + +ISD GLA C D S A+ GT GY Sbjct: 305 GLEHMHKRC---IVYRDLKPANILLDENGHIRISDLGLA--C--DFSKKKPHASVGTHGY 357 Query: 501 IAPELYSRNFGGVSYKS--DVYSFGMLVLEMVSG 406 +APE+ S+ G SY S D +SFG ++ +++ G Sbjct: 358 MAPEVLSK---GTSYDSCADWFSFGCMLYKLLKG 388
>CHK1_DROME (O61661) Serine/threonine-protein kinase grp (EC 2.7.11.1) (Protein| grapes) (Chk1 homolog) Length = 512 Score = 59.7 bits (143), Expect = 8e-09 Identities = 36/105 (34%), Positives = 58/105 (55%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ Y HQ + I H D+KP N+LLD + N KISDFG+A + L GT+ Y Sbjct: 130 GLNYLHQ---RGIAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPY 186 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDE 367 +APE+ + + + +D++S G++++ M++G D N E Sbjct: 187 VAPEVLQKAYH--AQPADLWSCGVILVTMLAGELPWDQPSTNCTE 229
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 59.7 bits (143), Expect = 8e-09 Identities = 47/173 (27%), Positives = 85/173 (49%), Gaps = 1/173 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L + + KI DFGLA R G++ Sbjct: 534 QGMDYLHA---KNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSIL 590 Query: 504 YIAPELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 ++APE+ + S++SDVY+FG+++ E+++ + N+D++ + Sbjct: 591 WMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYG-HISNKDQILF--------MV 641 Query: 327 GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQNL 169 G L +M+ + L + I++ PK+RP ++NML L+ L Sbjct: 642 GRGL-LRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTL 693
>KOIA_SCHPO (Q9Y7J6) Putative serine/threonine-protein kinase C1778.10c (EC| 2.7.11.1) Length = 550 Score = 59.3 bits (142), Expect = 1e-08 Identities = 39/96 (40%), Positives = 54/96 (56%), Gaps = 5/96 (5%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLC----ARDQSILTLTAA-RG 514 +EY H C I+H D+KP NIL D N + KI+DFG AK+ T ++ G Sbjct: 166 IEYMHS-CG--IIHRDLKPENILFDGNMHVKITDFGTAKILPPKYVNSPDYTTFPSSFVG 222 Query: 513 TMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 T Y+APEL SR VS SD+++F +V +M+ G Sbjct: 223 TAEYVAPELLSRQV--VSKSSDLWAFACVVYQMIVG 256
>CHK1_XENLA (Q6DE87) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (xChk1| protein) Length = 474 Score = 59.3 bits (142), Expect = 1e-08 Identities = 53/158 (33%), Positives = 75/158 (47%), Gaps = 9/158 (5%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+EY H + I H DIKP N+LLD KISDFGLA + + L GT+ Y Sbjct: 117 GVEYLH---SIGITHRDIKPENLLLDERDQLKISDFGLATVFRHNGKERLLNKMCGTLPY 173 Query: 501 IAPELY-SRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVE--------NQDEVYLPEW 349 +APEL SR F + DV+S G+++ M++G D E + YL W Sbjct: 174 VAPELIKSRAFH--ADPVDVWSCGIVLTAMLAGELPWDQPNEVCQEYCDWKEKNHYLTPW 231 Query: 348 IYEKVISGHDWELTLEMTAEDKEKMMQLTIVGLWSIQW 235 K IS L +M E+ + ++TI + +W Sbjct: 232 ---KKISATPLALLCKMLTENPQS--RITIPDIKKDRW 264
>GCN2_SCHPO (Q9HGN1) Serine/threonine-protein kinase gcn2 (EC 2.7.11.1)| Length = 1576 Score = 59.3 bits (142), Expect = 1e-08 Identities = 41/101 (40%), Positives = 54/101 (53%), Gaps = 13/101 (12%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLA-----------KLCARDQSILT 532 + Y H ++ ++H D+KP NI LD N N K+ DFGLA K R + Sbjct: 760 LAYIH---SRGMMHRDLKPGNIFLDENRNVKLGDFGLATENENYQDNNDKWKNRQSADED 816 Query: 531 LTAARGTMGYIAPELYSRNFGGVSY--KSDVYSFGMLVLEM 415 LT GT Y+APEL SR GV Y K D+YS G+++ EM Sbjct: 817 LTTGVGTALYVAPELLSRR-NGVRYDAKVDMYSLGIILFEM 856 Score = 36.2 bits (82), Expect = 0.096 Identities = 28/103 (27%), Positives = 46/103 (44%), Gaps = 13/103 (12%) Frame = -2 Query: 675 EYXHQGCNQRILHFDIKPHNILLDYNFN---PKISDFGLAKLCA----------RDQSIL 535 E G + + LH D N++L ++ + K+ DFG + QSI Sbjct: 364 ELHRLGISHKSLHLD----NVVLFHSGHRTFAKLMDFGFTRTLRDMNASHPFNINSQSIT 419 Query: 534 TLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 + G PE+ +F S K+D++ FG+LVL+M+ G Sbjct: 420 NILPE----GLYPPEVSESSFAAASRKTDIWCFGLLVLQMLCG 458
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 58.9 bits (141), Expect = 1e-08 Identities = 34/108 (31%), Positives = 65/108 (60%), Gaps = 1/108 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L + KI DFGLA + +R G++ Sbjct: 602 QGMDYLHA---KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL 658 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 ++APE + ++ S++SDVY+FG+++ E+++G+ ++ N+D++ Sbjct: 659 WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYS-NINNRDQI 705
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 58.9 bits (141), Expect = 1e-08 Identities = 34/108 (31%), Positives = 65/108 (60%), Gaps = 1/108 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L + KI DFGLA + +R G++ Sbjct: 602 QGMDYLHA---KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL 658 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 ++APE + ++ S++SDVY+FG+++ E+++G+ ++ N+D++ Sbjct: 659 WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYS-NINNRDQI 705
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 58.9 bits (141), Expect = 1e-08 Identities = 34/108 (31%), Positives = 65/108 (60%), Gaps = 1/108 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L + KI DFGLA + +R G++ Sbjct: 188 QGMDYLHA---KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL 244 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 ++APE + ++ S++SDVY+FG+++ E+++G+ ++ N+D++ Sbjct: 245 WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYS-NINNRDQI 291
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 58.9 bits (141), Expect = 1e-08 Identities = 34/108 (31%), Positives = 65/108 (60%), Gaps = 1/108 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L + KI DFGLA + +R G++ Sbjct: 172 QGMDYLHA---KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL 228 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 ++APE + ++ S++SDVY+FG+++ E+++G+ ++ N+D++ Sbjct: 229 WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYS-NINNRDQI 275
>GCN2_YEAST (P15442) Serine/threonine-protein kinase GCN2 (EC 2.7.11.1)| Length = 1590 Score = 58.9 bits (141), Expect = 1e-08 Identities = 39/101 (38%), Positives = 53/101 (52%), Gaps = 12/101 (11%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSIL------------ 535 + Y H +Q I+H D+KP NI +D + N KI DFGLAK R IL Sbjct: 754 LSYIH---SQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSD 810 Query: 534 TLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 412 LT+A GT Y+A E+ G + K D+YS G++ EM+ Sbjct: 811 NLTSAIGTAMYVATEVLD-GTGHYNEKIDMYSLGIIFFEMI 850
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 58.9 bits (141), Expect = 1e-08 Identities = 34/108 (31%), Positives = 65/108 (60%), Gaps = 1/108 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L + KI DFGLA + +R G++ Sbjct: 562 QGMDYLHA---KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL 618 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 ++APE + ++ S++SDVY+FG+++ E+++G+ ++ N+D++ Sbjct: 619 WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYS-NINNRDQI 665
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 58.9 bits (141), Expect = 1e-08 Identities = 34/108 (31%), Positives = 65/108 (60%), Gaps = 1/108 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L + KI DFGLA + +R G++ Sbjct: 124 QGMDYLHA---KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL 180 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 ++APE + ++ S++SDVY+FG+++ E+++G+ ++ N+D++ Sbjct: 181 WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYS-NINNRDQI 227
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 58.5 bits (140), Expect = 2e-08 Identities = 34/108 (31%), Positives = 63/108 (58%), Gaps = 1/108 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L KI DFGLA + +R + G++ Sbjct: 454 QGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSIL 510 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 ++APE + ++ S++SDVYS+G+++ E+++G + N+D++ Sbjct: 511 WMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELPYS-HINNRDQI 557
>KOK0_YEAST (Q12236) Probable serine/threonine-protein kinase YOL100W (EC| 2.7.11.1) Length = 1081 Score = 58.5 bits (140), Expect = 2e-08 Identities = 34/101 (33%), Positives = 59/101 (58%), Gaps = 9/101 (8%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILT------LTAAR 517 ++Y H + I+H DIKP NILLD K++DFG AKL + ++ T ++ Sbjct: 291 IDYLH---SNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSK 347 Query: 516 ---GTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 GT Y++PEL + +F Y+ D+++FG ++ +M++G+ Sbjct: 348 SFVGTAEYVSPELLNDSF--TDYRCDIWAFGCILFQMIAGK 386
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 58.5 bits (140), Expect = 2e-08 Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 3/186 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 + + + HQ I+H D+KP NI++ K+ DFG+A+ A S+ A GT Sbjct: 124 QALNFSHQN---GIIHRDVKPANIMISATNAVKVMDFGIARAIADSTSVTQTAAVIGTAQ 180 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS- 328 Y++PE V +SDVYS G ++ E+++G P +I + +S Sbjct: 181 YLSPE--QARGDSVDARSDVYSLGCVLYEILTGE---------------PPFIGDSPVSV 223 Query: 327 --GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQNLQIPPK 154 H E + + + + L V L ++ NP+NR + R+ + Q P Sbjct: 224 AYQHVREDPIPPSQRHEGISVDLDAVVLKALAKNPENRYQTAAEMRADLIRVHSGQPPEA 283 Query: 153 PFVSSD 136 P V +D Sbjct: 284 PKVLTD 289
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 58.2 bits (139), Expect = 2e-08 Identities = 34/108 (31%), Positives = 63/108 (58%), Gaps = 1/108 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L KI DFGLA + +R + G++ Sbjct: 454 QGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL 510 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 ++APE + ++ S++SDVYS+G+++ E+++G + N+D++ Sbjct: 511 WMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYS-HINNRDQI 557
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 58.2 bits (139), Expect = 2e-08 Identities = 34/108 (31%), Positives = 63/108 (58%), Gaps = 1/108 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L KI DFGLA + +R + G++ Sbjct: 454 QGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL 510 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 ++APE + ++ S++SDVYS+G+++ E+++G + N+D++ Sbjct: 511 WMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYS-HINNRDQI 557
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 58.2 bits (139), Expect = 2e-08 Identities = 34/108 (31%), Positives = 63/108 (58%), Gaps = 1/108 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L KI DFGLA + +R + G++ Sbjct: 187 QGMDYLHA---KNIIHRDMKSNNIFLHGGLTVKIGDFGLATVKSRWSGSQQVEQPTGSIL 243 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 ++APE + ++ S++SDVYS+G+++ E+++G + N+D++ Sbjct: 244 WMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELPYS-HINNRDQI 290
>KDC2_DROME (P16912) Protein kinase DC2 (EC 2.7.11.1)| Length = 583 Score = 58.2 bits (139), Expect = 2e-08 Identities = 48/137 (35%), Positives = 77/137 (56%), Gaps = 1/137 (0%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 +EY H + +I++ D+KP N+L++ + + KI+DFG AK RD++ TL GT YI Sbjct: 385 LEYLH---SLQIVYRDLKPENLLINRDGHLKITDFGFAKK-LRDRT-WTLC---GTPEYI 436 Query: 498 APELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH- 322 APE+ G + D ++ G+L+ EM+ G P + Q P IYEK++SG Sbjct: 437 APEIIQSK--GHNKAVDWWALGVLIYEMLVG---YPPFYDEQ-----PFGIYEKILSGKI 486 Query: 321 DWELTLEMTAEDKEKMM 271 +WE ++ A+D K + Sbjct: 487 EWERHMDPIAKDLIKKL 503
>CHK1_RAT (Q91ZN7) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 58.2 bits (139), Expect = 2e-08 Identities = 41/107 (38%), Positives = 54/107 (50%), Gaps = 8/107 (7%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 I H DIKP N+LLD N KISDFGLA + + L GT+ Y+APEL R Sbjct: 126 ITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFH 185 Query: 465 VSYKSDVYSFGMLVLEMVSGR----RNSDPSVENQD----EVYLPEW 349 DV+S G+++ M++G + SD E D + YL W Sbjct: 186 AE-PVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPW 231
>CHK1_MOUSE (O35280) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 58.2 bits (139), Expect = 2e-08 Identities = 41/107 (38%), Positives = 54/107 (50%), Gaps = 8/107 (7%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 I H DIKP N+LLD N KISDFGLA + + L GT+ Y+APEL R Sbjct: 126 ITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFH 185 Query: 465 VSYKSDVYSFGMLVLEMVSGR----RNSDPSVENQD----EVYLPEW 349 DV+S G+++ M++G + SD E D + YL W Sbjct: 186 AE-PVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPW 231
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 58.2 bits (139), Expect = 2e-08 Identities = 54/164 (32%), Positives = 86/164 (52%), Gaps = 2/164 (1%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLA-KLCARDQSILTLTAARGTMG 505 GM Y H + ILH D+ N+LL N N KI+DFGLA +L + TL GT Sbjct: 123 GMLYLH---SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLC---GTPN 176 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSD-PSVENQDEVYLPEWIYEKVIS 328 YI+PE+ +R+ G+ +SDV+S G + ++ GR D +V+N KV+ Sbjct: 177 YISPEIATRSAHGL--ESDVWSLGCMFYTLLIGRPPFDTDTVKN---------TLNKVVL 225 Query: 327 GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVN 196 D+E+ ++ E K+ + QL ++ NP +R S++ V++ Sbjct: 226 A-DYEMPTFLSIEAKDLIHQL-------LRRNPADRLSLSSVLD 261
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 58.2 bits (139), Expect = 2e-08 Identities = 36/96 (37%), Positives = 57/96 (59%), Gaps = 3/96 (3%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ Y H I+H D+KP N+LLD+ +N KI+DFG+A L + L + G+ Y Sbjct: 143 GVSYCHA---LGIVHRDLKPENLLLDHKYNIKIADFGMAALETEGK---LLETSCGSPHY 196 Query: 501 IAPELYSRNFGGVSYK---SDVYSFGMLVLEMVSGR 403 APE+ S G+ Y+ SDV+S G+++ +++GR Sbjct: 197 AAPEIVS----GIPYQGFASDVWSCGVILFALLTGR 228
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 57.8 bits (138), Expect = 3e-08 Identities = 34/108 (31%), Positives = 63/108 (58%), Gaps = 1/108 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L KI DFGLA + +R + G++ Sbjct: 129 QGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL 185 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 ++APE + ++ S++SDVYS+G+++ E+++G + N+D++ Sbjct: 186 WMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGEL-PYAHINNRDQI 232
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 57.8 bits (138), Expect = 3e-08 Identities = 32/92 (34%), Positives = 53/92 (57%), Gaps = 1/92 (1%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPE-LYSRNFG 469 ++H D+KP NI++D + ++ DFGLAK A D +I GT Y+APE + Sbjct: 240 LVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAAITEAGKLVGTYRYMAPEQILGEPLD 299 Query: 468 GVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQ 373 G ++D+YS G+++ E++SGR D ++ Sbjct: 300 G---RADLYSLGVILYELLSGRPPFDAKTPHE 328
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 57.8 bits (138), Expect = 3e-08 Identities = 34/108 (31%), Positives = 63/108 (58%), Gaps = 1/108 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L KI DFGLA + +R + G++ Sbjct: 454 QGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL 510 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 ++APE + ++ S++SDVYS+G+++ E+++G + N+D++ Sbjct: 511 WMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGEL-PYAHINNRDQI 557
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 57.8 bits (138), Expect = 3e-08 Identities = 49/187 (26%), Positives = 87/187 (46%), Gaps = 11/187 (5%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RGM+Y ++R +H D+ N+L+ ++ KI+DFGLA+ T R + Sbjct: 542 RGMDYL---ASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIK 598 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 ++APE F KSDV+S+G+L+ E+++ + P++ + +E +Y ++SG Sbjct: 599 WMAPESLQEKF--YDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEE------LYTYLMSG 650 Query: 324 HDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQ---------- 175 E + + M + I+ +N +RP T++V + LQ Sbjct: 651 QRMEKPAKCS-------MNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDI 703 Query: 174 -NLQIPP 157 NL PP Sbjct: 704 ANLDTPP 710
>PKH1_YEAST (Q03407) Serine/threonine-protein kinase PKH1 (EC 2.7.11.1)| (3-phosphoinositide-dependent protein kinase 1) Length = 766 Score = 57.8 bits (138), Expect = 3e-08 Identities = 34/95 (35%), Positives = 53/95 (55%), Gaps = 11/95 (11%) Frame = -2 Query: 654 NQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQS-------ILTLTAAR----GTM 508 N I+H DIKP NILLD N K++DFG AK+ + S L A GT Sbjct: 242 NIGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSKSFVGTA 301 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y++PEL + N+ + D+++FG ++ +M++G+ Sbjct: 302 EYVSPELLNDNY--TDSRCDIWAFGCILYQMLAGK 334
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 57.8 bits (138), Expect = 3e-08 Identities = 36/106 (33%), Positives = 59/106 (55%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM + Q + +H D++ NIL+ + KI+DFGLA++ D A+ + + Sbjct: 344 GMAFIEQ---RNYIHRDLRAANILVSASLVCKIADFGLARII-EDNEYTAREGAKFPIKW 399 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 APE NFG + KSDV+SFG+L++E+V+ R P + N + + Sbjct: 400 TAPEAI--NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVI 443
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 57.8 bits (138), Expect = 3e-08 Identities = 36/106 (33%), Positives = 59/106 (55%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM + Q + +H D++ NIL+ + KI+DFGLA++ D A+ + + Sbjct: 365 GMAFIEQ---RNYIHRDLRAANILVSASLVCKIADFGLARII-EDNEYTAREGAKFPIKW 420 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 APE NFG + KSDV+SFG+L++E+V+ R P + N + + Sbjct: 421 TAPEAI--NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVI 464
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 57.4 bits (137), Expect = 4e-08 Identities = 36/106 (33%), Positives = 59/106 (55%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM + Q + +H D++ NIL+ + KI+DFGLA++ D A+ + + Sbjct: 367 GMAFIEQ---RNYIHRDLRAANILVSASLVCKIADFGLARVI-EDNEYTAREGAKFPIKW 422 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 APE NFG + KSDV+SFG+L++E+V+ R P + N + + Sbjct: 423 TAPEAI--NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVI 466
>TSSK1_HUMAN (Q9BXA7) Testis-specific serine/threonine-protein kinase 1 (EC| 2.7.11.1) (TSSK-1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A) Length = 367 Score = 57.4 bits (137), Expect = 4e-08 Identities = 48/163 (29%), Positives = 77/163 (47%), Gaps = 13/163 (7%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQS---ILTLTAARGTMGYIAPELYSRN 475 ++H D+K N+LLD +FN K+SDF +K C RD S L+ T G+ Y APE+ Sbjct: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFC-GSPAYAAPEVLQ-- 188 Query: 474 FGGVSYKS---DVYSFGMLVLEMVSGRRNSDPS-------VENQDEVYLPEWIYEKVISG 325 G+ Y+ D++S G+++ MV G D S ++ + V P K ++G Sbjct: 189 --GIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPR---SKHLTG 243 Query: 324 HDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVN 196 +L M D + + + + L PK R S + +N Sbjct: 244 ECKDLIYHMLQPDVNRRLHIDEI-LSHCWMQPKARGSPSVAIN 285
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 57.4 bits (137), Expect = 4e-08 Identities = 30/91 (32%), Positives = 53/91 (58%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 +EY H + I+H D+KP NILL+ + + +I+DFG AK+ + D + GT Y+ Sbjct: 196 LEYLH---GKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPDSKQARANSFVGTAQYV 252 Query: 498 APELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +PEL + SD+++ G ++ ++V+G Sbjct: 253 SPELLTEK--SACKSSDLWALGCIIYQLVAG 281
>HCK_MACFA (Q95M30) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 503 Score = 57.4 bits (137), Expect = 4e-08 Identities = 36/106 (33%), Positives = 59/106 (55%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM + Q + +H D++ NIL+ + KI+DFGLA++ D A+ + + Sbjct: 345 GMAFIEQ---RNYIHRDLRAANILVSASLVCKIADFGLARII-EDNEYTAREGAKFPIKW 400 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 APE NFG + KSDV+SFG+L++E+V+ R P + N + + Sbjct: 401 TAPEAI--NFGSSTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVI 444
>CHK1_HUMAN (O14757) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 57.4 bits (137), Expect = 4e-08 Identities = 41/107 (38%), Positives = 54/107 (50%), Gaps = 8/107 (7%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 I H DIKP N+LLD N KISDFGLA + + L GT+ Y+APEL R Sbjct: 126 ITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFH 185 Query: 465 VSYKSDVYSFGMLVLEMVSGR----RNSDPSVENQD----EVYLPEW 349 DV+S G+++ M++G + SD E D + YL W Sbjct: 186 AE-PVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPW 231
>PKNA2_BIFLO (Q8G4G1) Probable serine/threonine-protein kinase pknA2 (EC| 2.7.11.1) Length = 757 Score = 57.4 bits (137), Expect = 4e-08 Identities = 33/82 (40%), Positives = 52/82 (63%), Gaps = 1/82 (1%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTA-ARGTMGYIAPELYSRNFG 469 ++H DIKP NIL++ + +I+DFGLAK A Q+ L+ T GT Y+APE+ N Sbjct: 136 VVHRDIKPENILINDRGHVQITDFGLAK--AASQATLSSTGMLLGTAAYLAPEMIENN-- 191 Query: 468 GVSYKSDVYSFGMLVLEMVSGR 403 + + D+YS G++ EM++G+ Sbjct: 192 QATAQGDLYSVGIMAWEMLTGK 213
>VGFR2_COTJA (P52583) Vascular endothelial growth factor receptor 2 precursor (EC| 2.7.10.1) (VEGFR-2) (Endothelial kinase receptor EK1) (Quek 1) (Quek1) Length = 1348 Score = 57.0 bits (136), Expect = 5e-08 Identities = 54/182 (29%), Positives = 90/182 (49%), Gaps = 2/182 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RGME+ +++ +H D+ NILL N KI DFGLA+ +D + AR + Sbjct: 1007 RGMEFL---ASRKCIHRDLAARNILLSDNNVVKICDFGLARDIYKDPDYVRKGDARLPLK 1063 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 ++APE ++ R + + +SDV+SFG+L+ E+ S + P V+ +E ++ Sbjct: 1064 WMAPETIFDRVY---TIQSDVWSFGVLLWEIFSLGASPYPGVKIDEE------FCRRLKE 1114 Query: 327 GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQ-NLQIPPKP 151 G T E M T++ W +PK RP+ +++V L LQ N++ K Sbjct: 1115 GTRMRAPDYTTPE-----MYQTMLDCW--HGDPKQRPTFSELVEHLGNLLQANVRQDGKD 1167 Query: 150 FV 145 +V Sbjct: 1168 YV 1169
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 57.0 bits (136), Expect = 5e-08 Identities = 53/167 (31%), Positives = 87/167 (52%), Gaps = 2/167 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNP--KISDFGLAKLCARDQSILTLTAARGT 511 + + Y H ++ I+H DIKP N+LL YN + KI DFGLA + ++ T +GT Sbjct: 117 KALAYLHS-LDRPIVHRDIKPQNMLL-YNQHEDLKICDFGLATDMSNNK-----TDMQGT 169 Query: 510 MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVI 331 + Y+APE + K DVYSFG+++ E+++ R+ +EN + Y I + + Sbjct: 170 LRYMAPEAIKHL--KYTAKCDVYSFGIMLWELMT-RQLPYSHLENPNSQYA---IMKAIS 223 Query: 330 SGHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNML 190 SG +L +E D + ++ + I NP+ RPSM ++ L Sbjct: 224 SGE--KLPMEAVRSDCPEGIKQLMECCMDI--NPEKRPSMKEIEKFL 266
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)| Length = 508 Score = 57.0 bits (136), Expect = 5e-08 Identities = 34/94 (36%), Positives = 52/94 (55%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+ Y H+ ++++H DIKP NILL+ N K+ DFG++ + T GT Sbjct: 335 RGLSYLHE---KKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLA----TTFTGTSF 387 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y+APE S SDV+S G+ +LE+ +G+ Sbjct: 388 YMAPERIQGQ--PYSVTSDVWSLGLTILEVANGK 419
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 57.0 bits (136), Expect = 5e-08 Identities = 37/106 (34%), Positives = 57/106 (53%) Frame = -2 Query: 651 QRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNF 472 Q +H D++ NIL+ + KI+DFGLA+L D A+ + + APE N+ Sbjct: 357 QNYIHRDLRAANILVSDTLSCKIADFGLARLI-EDNEYTAREGAKFPIKWTAPEAI--NY 413 Query: 471 GGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKV 334 G + KSDV+SFG+L+ E+V+ R P + N + + E Y V Sbjct: 414 GTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 459
>PKNB_BIFLO (Q8G6P9) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 690 Score = 57.0 bits (136), Expect = 5e-08 Identities = 35/95 (36%), Positives = 56/95 (58%), Gaps = 3/95 (3%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG-- 505 ++Y H+ I+H DIKP NI++ K+ DFG+A+ A D S T+T ++G +G Sbjct: 134 LDYSHR---MGIIHRDIKPGNIMISEQGVVKVMDFGIAR--ALDDSAATMTQSQGVVGTA 188 Query: 504 -YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y++PE V +SD+YS G ++ EM++GR Sbjct: 189 QYLSPE--QARGETVDMRSDLYSAGCVLYEMLTGR 221
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 57.0 bits (136), Expect = 5e-08 Identities = 32/94 (34%), Positives = 56/94 (59%), Gaps = 1/94 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L KI DFGLA + R + G++ Sbjct: 445 QGMDYLHA---KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQVEQLTGSIL 501 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 ++APE + ++ S++SDVYS+G+++ E+++G Sbjct: 502 WMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTG 535
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 57.0 bits (136), Expect = 5e-08 Identities = 53/164 (32%), Positives = 86/164 (52%), Gaps = 2/164 (1%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLA-KLCARDQSILTLTAARGTMG 505 GM Y H + ILH D+ NILL N N KI+DFGLA +L + TL GT Sbjct: 123 GMLYLH---SHGILHRDLTLSNILLTRNMNIKIADFGLATQLNMPHEKHYTLC---GTPN 176 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSD-PSVENQDEVYLPEWIYEKVIS 328 YI+PE+ +R+ G+ +SD++S G + ++ GR D +V+N KV+ Sbjct: 177 YISPEIATRSAHGL--ESDIWSLGCMFYTLLIGRPPFDTDTVKN---------TLNKVVL 225 Query: 327 GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVN 196 D+E+ ++ E ++ + QL ++ NP +R S++ V++ Sbjct: 226 A-DYEMPAFLSREAQDLIHQL-------LRRNPADRLSLSSVLD 261
>RK_HUMAN (Q15835) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 563 Score = 56.6 bits (135), Expect = 7e-08 Identities = 38/107 (35%), Positives = 58/107 (54%), Gaps = 3/107 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+E+ HQ +RI++ D+KP N+LLD + N +ISD GLA QS GT G+ Sbjct: 304 GLEHLHQ---RRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQS--KTKGYAGTPGF 358 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR---RNSDPSVENQD 370 +APEL + D ++ G+ + EM++ R R VEN++ Sbjct: 359 MAPELLQGE--EYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKE 403
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 56.6 bits (135), Expect = 7e-08 Identities = 30/81 (37%), Positives = 51/81 (62%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 I+H DIKPHNI++ + K++DFG+AK + + +I T G+ Y++PE Sbjct: 129 IVHRDIKPHNIMVTDDDIIKVTDFGIAK-ASNESTITTTNKVVGSAHYLSPE--QAQGIP 185 Query: 465 VSYKSDVYSFGMLVLEMVSGR 403 V ++D+YSFG+++ EM +G+ Sbjct: 186 VDCRTDIYSFGIVLYEMATGK 206
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 56.6 bits (135), Expect = 7e-08 Identities = 47/160 (29%), Positives = 84/160 (52%), Gaps = 1/160 (0%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 ++Y H ++ ILH DIKP NIL+ +N K++DFG + Q TL GT+ Y+ Sbjct: 211 LDYMH---SKNILHRDIKPENILIGFNNTIKLTDFGWSVYNEDGQKRKTLC---GTIDYL 264 Query: 498 APELY-SRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH 322 +PEL SR + K DV++ G+L E++ G S P E+ E+ Y +++ Sbjct: 265 SPELIKSREYNN---KVDVWALGVLTYELLVG---SPPFEEDTKEM-----TYRRILR-C 312 Query: 321 DWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKV 202 D + L ++ + ++ +++L +Q+ P R +++V Sbjct: 313 DLKFPLNVSPQARDLIVRL-------LQFEPSKRIPLSEV 345
>TSSK2_MOUSE (O54863) Testis-specific serine/threonine-protein kinase 2 (EC| 2.7.11.1) (TSSK-2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) Length = 357 Score = 56.6 bits (135), Expect = 7e-08 Identities = 35/92 (38%), Positives = 52/92 (56%), Gaps = 5/92 (5%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQS--ILTLTAARGTMGYIAPELYSRNF 472 ++H D+K N+LLD +FN K+SDFG +K C RD S I+ G+ Y APE+ Sbjct: 132 VVHRDLKCENLLLDKDFNIKLSDFGFSKGCLRDGSGRIVLSKTFCGSAAYAAPEVRQ--- 188 Query: 471 GGVSYKS---DVYSFGMLVLEMVSGRRNSDPS 385 G+ Y+ D++S G+++ MV G D S Sbjct: 189 -GIPYQPKVYDIWSLGVILYIMVCGSMPYDDS 219
>KSG1_SCHPO (Q12701) Serine/threonine-protein kinase ksg1 (EC 2.7.11.1)| Length = 592 Score = 56.6 bits (135), Expect = 7e-08 Identities = 33/104 (31%), Positives = 56/104 (53%), Gaps = 12/104 (11%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLC------------ARDQSIL 535 ++Y H + ++H D+KP NILLD N KI+DFG AK+ D+ Sbjct: 211 IDYMH---GRGVIHRDLKPENILLDDNMRTKITDFGSAKILNSSHGSHEEDTHHADKPQA 267 Query: 534 TLTAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 + GT Y++PE+ S G + SD+++FG ++ +M++G+ Sbjct: 268 HSRSFVGTARYVSPEVLSDKIAGTA--SDIWAFGCILFQMLAGK 309
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 56.6 bits (135), Expect = 7e-08 Identities = 47/156 (30%), Positives = 77/156 (49%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y + +H D++ NIL+ N KI+DFGLA+L D A+ + + Sbjct: 376 GMAYIER---MNYIHRDLRSANILVGDNLVCKIADFGLARLI-EDNEYTARQGAKFPIKW 431 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH 322 APE + +G + KSDV+SFG+L+ E+V+ R P + N++ + E+V G+ Sbjct: 432 TAPE--AALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNRE-------VLEQVERGY 482 Query: 321 DWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPS 214 + A E M+Q W + +P+ RP+ Sbjct: 483 RMPCPQDCPASLHELMLQ-----CW--KKDPEERPT 511
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 56.6 bits (135), Expect = 7e-08 Identities = 36/92 (39%), Positives = 51/92 (55%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ Y H N I+H D+KP N+LLD N N KI+DFGL+ L+ A G+ Y Sbjct: 134 GVSYCH---NHMIVHRDLKPENLLLDANKNIKIADFGLSNYMTDGD---LLSTACGSPNY 187 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 APEL S V + D++S G+++ M+ G Sbjct: 188 AAPELISNKL-YVGPEVDLWSCGVILYAMLCG 218
>KPCG_RABIT (P10829) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| (PKC-delta) Length = 697 Score = 56.2 bits (134), Expect = 9e-08 Identities = 41/121 (33%), Positives = 68/121 (56%), Gaps = 3/121 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAAR---GT 511 G+ + H NQ I++ D+K N++LD + KI+DFG+ K +++ T R GT Sbjct: 467 GLFFLH---NQGIIYRDLKLDNVMLDAEGHIKITDFGMCK-----ENVFPGTTTRTFCGT 518 Query: 510 MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVI 331 YIAPE+ + G S D +SFG+L+ EM++G+ P + +DE L + I E+ + Sbjct: 519 PDYIAPEIIAYQPYGKSV--DWWSFGVLLYEMLAGQ----PPFDGEDEEELFQAIMEQTV 572 Query: 330 S 328 + Sbjct: 573 T 573
>KPCG_HUMAN (P05129) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 56.2 bits (134), Expect = 9e-08 Identities = 41/121 (33%), Positives = 68/121 (56%), Gaps = 3/121 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAAR---GT 511 G+ + H NQ I++ D+K N++LD + KI+DFG+ K +++ T R GT Sbjct: 467 GLFFLH---NQGIIYRDLKLDNVMLDAEGHIKITDFGMCK-----ENVFPGTTTRTFCGT 518 Query: 510 MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVI 331 YIAPE+ + G S D +SFG+L+ EM++G+ P + +DE L + I E+ + Sbjct: 519 PDYIAPEIIAYQPYGKSV--DWWSFGVLLYEMLAGQ----PPFDGEDEEELFQAIMEQTV 572 Query: 330 S 328 + Sbjct: 573 T 573
>RIPK5_XENLA (Q67E01) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 916 Score = 56.2 bits (134), Expect = 9e-08 Identities = 52/173 (30%), Positives = 71/173 (41%), Gaps = 2/173 (1%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ + H NQ ++H DIK N+LLD KI+D G K A + GT + Sbjct: 753 GIRFLH---NQGVVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIV-----GTPIH 804 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH 322 +APEL+S G DVY+FG+L + SG V LPE + H Sbjct: 805 MAPELFS---GKYDNSVDVYAFGILFWYICSG------------SVKLPEAFEKCASKDH 849 Query: 321 DWELTLEMTAEDKEKMMQLTIVGLWSIQWN--PKNRPSMTKVVNMLTGRLQNL 169 W + ++ + L WN P RP M V ML G + L Sbjct: 850 LWNNVRKGARPERLTIFDEECWKLMEACWNGDPSQRPLMGIVQPMLQGIMDRL 902
>MK01_HUMAN (P28482) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 56.2 bits (134), Expect = 9e-08 Identities = 36/95 (37%), Positives = 52/95 (54%), Gaps = 1/95 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSIL-TLTAARGTM 508 RG++Y H +LH D+KP N+LL+ + KI DFGLA++ D LT T Sbjct: 134 RGLKYIHSA---NVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 190 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y APE+ N G + D++S G ++ EM+S R Sbjct: 191 WYRAPEI-MLNSKGYTKSIDIWSVGCILAEMLSNR 224
>MK01_BOVIN (P46196) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 56.2 bits (134), Expect = 9e-08 Identities = 36/95 (37%), Positives = 52/95 (54%), Gaps = 1/95 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSIL-TLTAARGTM 508 RG++Y H +LH D+KP N+LL+ + KI DFGLA++ D LT T Sbjct: 134 RGLKYIHSA---NVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 190 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y APE+ N G + D++S G ++ EM+S R Sbjct: 191 WYRAPEI-MLNSKGYTKSIDIWSVGCILAEMLSNR 224
>MK01_XENLA (P26696) Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Myelin| xP42 protein kinase) (Myelin basic protein kinase) (MBP kinase) (M phase MAP kinase) Length = 361 Score = 56.2 bits (134), Expect = 9e-08 Identities = 36/95 (37%), Positives = 52/95 (54%), Gaps = 1/95 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSIL-TLTAARGTM 508 RG++Y H +LH D+KP N+LL+ + KI DFGLA++ D LT T Sbjct: 138 RGLKYIHSA---NVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 194 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y APE+ N G + D++S G ++ EM+S R Sbjct: 195 WYRAPEI-MLNSKGYTKSIDIWSVGCILAEMLSNR 228
>KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC 2.7.11.11) (PKA| 3) Length = 398 Score = 56.2 bits (134), Expect = 9e-08 Identities = 38/91 (41%), Positives = 54/91 (59%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 +EY H ++ I++ D+KP NILLD N + KI+DFG AK +T T GT YI Sbjct: 199 LEYLH---SKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD----VTYTLC-GTPDYI 250 Query: 498 APELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 APE+ S + D +SFG+L+ EM++G Sbjct: 251 APEVVSTK--PYNKSVDWWSFGVLIYEMLAG 279
>KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC 2.7.11.11) (PKA| 1) (CDC25-suppressing protein kinase) (PK-25) Length = 397 Score = 56.2 bits (134), Expect = 9e-08 Identities = 38/91 (41%), Positives = 54/91 (59%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 +EY H ++ I++ D+KP NILLD N + KI+DFG AK +T T GT YI Sbjct: 198 LEYLH---SKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD----VTYTLC-GTPDYI 249 Query: 498 APELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 APE+ S + D +SFG+L+ EM++G Sbjct: 250 APEVVSTK--PYNKSIDWWSFGILIYEMLAG 278
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 56.2 bits (134), Expect = 9e-08 Identities = 51/164 (31%), Positives = 75/164 (45%), Gaps = 2/164 (1%) Frame = -2 Query: 654 NQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRN 475 +Q +H D+ N+L+ N K+ DFGLA+L D I + APE SR Sbjct: 305 SQNYIHRDLAARNVLVTENNLCKVGDFGLARLVKED--IYLSHEHNVPYKWTAPEALSR- 361 Query: 474 FGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGHDWELTLEMT 295 G S KSDV+SFG+L+ E+ S + P + N + + +V +G+ LE Sbjct: 362 -GHYSIKSDVWSFGVLLHEIFSRGQMPYPGMSNHE-------TFLRVDAGYRMPCPLECP 413 Query: 294 AEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTG--RLQNL 169 + M+ WS +PK RP + LTG R +NL Sbjct: 414 PNIHKLML-----SCWS--RDPKQRPCFKDLCEKLTGITRYENL 450
>YP150_YEAST (Q12152) Putative serine/threonine-protein kinase YPL150W (EC| 2.7.11.1) Length = 901 Score = 56.2 bits (134), Expect = 9e-08 Identities = 47/162 (29%), Positives = 78/162 (48%), Gaps = 4/162 (2%) Frame = -2 Query: 672 YXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAP 493 Y H + +H D+K NILLD N N K++DFG + C + TL GT Y+AP Sbjct: 147 YAH---SMHCVHRDLKLENILLDKNGNAKLTDFGFTREC---MTKTTLETVCGTTVYMAP 200 Query: 492 ELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRR--NSDPSVENQDEVYLPEWIYE-KVISG 325 EL R + G +K D++S G+++ +++G + D + + ++ E Y+ KVI Sbjct: 201 ELIERRTYDG--FKIDIWSLGVILYTLITGYLPFDDDDEAKTKWKIVNEEPKYDAKVIPD 258 Query: 324 HDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVV 199 +L + A+ NP RPS+++V+ Sbjct: 259 DARDLISRLLAK------------------NPGERPSLSQVL 282
>CHK1_CAEBR (Q61RA2) Serine/threonine-protein kinase chk-1 (EC 2.7.11.1)| Length = 493 Score = 56.2 bits (134), Expect = 9e-08 Identities = 41/125 (32%), Positives = 66/125 (52%), Gaps = 3/125 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G++Y H C+ I+H DIKP N+LL + KISDFG+A L + L + GT+ Y Sbjct: 137 GLKYIHD-CD--IVHRDIKPENLLLTTSHVLKISDFGMATLYRNEGKERLLDLSCGTIPY 193 Query: 501 IAPELYSRNFGGVSYKS---DVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVI 331 APE+ + G Y+ DV+S G++++ M++G D + YL +W+ + Sbjct: 194 AAPEVCA----GGKYRGPPIDVWSSGIVLIAMLTGELPWD-RASDSSYAYL-QWLGNNNL 247 Query: 330 SGHDW 316 + W Sbjct: 248 DENPW 252
>MK01_RAT (P63086) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 56.2 bits (134), Expect = 9e-08 Identities = 36/95 (37%), Positives = 52/95 (54%), Gaps = 1/95 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSIL-TLTAARGTM 508 RG++Y H +LH D+KP N+LL+ + KI DFGLA++ D LT T Sbjct: 132 RGLKYIHSA---NVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 188 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y APE+ N G + D++S G ++ EM+S R Sbjct: 189 WYRAPEI-MLNSKGYTKSIDIWSVGCILAEMLSNR 222
>MK01_MOUSE (P63085) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 56.2 bits (134), Expect = 9e-08 Identities = 36/95 (37%), Positives = 52/95 (54%), Gaps = 1/95 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSIL-TLTAARGTM 508 RG++Y H +LH D+KP N+LL+ + KI DFGLA++ D LT T Sbjct: 132 RGLKYIHSA---NVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 188 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y APE+ N G + D++S G ++ EM+S R Sbjct: 189 WYRAPEI-MLNSKGYTKSIDIWSVGCILAEMLSNR 222
>CHK1_CHICK (Q8AYC9) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 56.2 bits (134), Expect = 9e-08 Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 9/120 (7%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ Y H + I H D+KP N+LLD N KISDFGLA + + L GT+ Y Sbjct: 117 GVVYLH---SMGITHRDLKPENLLLDERDNLKISDFGLATVFKHNGRERLLNKMCGTLPY 173 Query: 501 IAPELYSR-NFGGVSYKSDVYSFGMLVLEMVSGR----RNSDPSVENQD----EVYLPEW 349 +APEL R F + DV++ G+++ M++G + SD E D + YL W Sbjct: 174 VAPELLRRPEFR--AEPVDVWACGVVLTAMLAGELPWDQPSDSCQEYSDWKERKTYLAPW 231
>KGS9_YEAST (P43637) Probable serine/threonine-protein kinase YGL179C (EC| 2.7.11.1) Length = 560 Score = 56.2 bits (134), Expect = 9e-08 Identities = 47/152 (30%), Positives = 75/152 (49%), Gaps = 13/152 (8%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCA-------RDQSILTLTA 523 G+EY H +Q I H DIKP N+L+ N KISDFG+A A L + Sbjct: 176 GLEYLH---SQGITHRDIKPSNLLISSNGTVKISDFGVAMSTATGSTNIQSSHEQLLKSR 232 Query: 522 ARGTMGYIAPELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRR--NSDPSVENQDEVY--- 361 A GT + APEL S S D++S G+ + ++ G+ N++ +E D + Sbjct: 233 ALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLPFNANSGLELFDSIINKP 292 Query: 360 LPEWIYEKVISGHDWELTLEMTAEDKEKMMQL 265 L YE++++G +T+E + K+ + +L Sbjct: 293 LEFPSYEEMLNGATSGITMEEYTDAKDLLKKL 324
>SHK2_SCHPO (Q10056) Serine/threonine-protein kinase shk2 (EC 2.7.11.1)| Length = 589 Score = 56.2 bits (134), Expect = 9e-08 Identities = 34/92 (36%), Positives = 57/92 (61%), Gaps = 1/92 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGL-AKLCARDQSILTLTAARGTM 508 +G+++ H + I+H DIK N+LLD + N KI+DFG A+L R +T+ GT Sbjct: 420 KGIQHLHA---RNIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRVTMV---GTP 473 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMV 412 ++APE+ +N G K D++S G++++EM+ Sbjct: 474 YWMAPEVVKQNEYGT--KVDIWSLGIMIIEMI 503
>ST32C_MOUSE (Q8QZV4) Serine/threonine-protein kinase 32C (EC 2.7.11.1)| Length = 488 Score = 56.2 bits (134), Expect = 9e-08 Identities = 40/121 (33%), Positives = 60/121 (49%), Gaps = 14/121 (11%) Frame = -2 Query: 654 NQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSR- 478 +Q I+H D+KP NILLD + ++DF +A + + TA GT Y+APE++ Sbjct: 210 SQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE---RATALAGTKPYMAPEIFHSF 266 Query: 477 -NFG-GVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDE-----------VYLPEWIYEK 337 N G G S++ D +S G++ E++ G R D N E Y+P W E Sbjct: 267 VNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEM 326 Query: 336 V 334 V Sbjct: 327 V 327
>ST32C_HUMAN (Q86UX6) Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE)| (YANK3) Length = 486 Score = 55.8 bits (133), Expect = 1e-07 Identities = 40/120 (33%), Positives = 59/120 (49%), Gaps = 14/120 (11%) Frame = -2 Query: 651 QRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSR-- 478 Q I+H D+KP NILLD + ++DF +A + + TA GT Y+APE++ Sbjct: 210 QHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGE---RATALAGTKPYMAPEIFHSFV 266 Query: 477 NFG-GVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDE-----------VYLPEWIYEKV 334 N G G S++ D +S G++ E++ G R D N E Y+P W E V Sbjct: 267 NGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMV 326
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 55.8 bits (133), Expect = 1e-07 Identities = 33/92 (35%), Positives = 58/92 (63%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+++ H + I++ D+KP NILLD + K++DFGL+K + + GT+ Y Sbjct: 174 GLDHLH---SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEK--KAYSFCGTVEY 228 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +APE+ +R G S+ +D +S+G+L+ EM++G Sbjct: 229 MAPEVVNRQ--GHSHSADWWSYGVLMFEMLTG 258 Score = 46.2 bits (108), Expect = 9e-05 Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 4/87 (4%) Frame = -2 Query: 654 NQRILHFDIKPHNIL-LDYNFNP---KISDFGLAKLCARDQSILTLTAARGTMGYIAPEL 487 +Q ++H D+KP NIL +D + +P +I DFG AK D +L T ++APE+ Sbjct: 526 SQGVVHRDLKPSNILYVDESGDPESIRICDFGFAKQLRADNGLLMTPCY--TANFVAPEV 583 Query: 486 YSRNFGGVSYKSDVYSFGMLVLEMVSG 406 R G D++S G+L+ M++G Sbjct: 584 LKRQ--GYDEGCDIWSLGILLYTMLAG 608
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 55.8 bits (133), Expect = 1e-07 Identities = 37/104 (35%), Positives = 57/104 (54%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y + +H D++ NIL+ N KI+DFGLA+L D A+ + + Sbjct: 375 GMAYIER---MNYIHRDLRAANILVGDNLVCKIADFGLARLI-EDNEYTARQGAKFPIKW 430 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQD 370 APE + FG + KSDV+SFG+L+ E+V+ R P + N++ Sbjct: 431 TAPE--AALFGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNRE 472
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 55.8 bits (133), Expect = 1e-07 Identities = 33/92 (35%), Positives = 58/92 (63%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+++ H + I++ D+KP NILLD + K++DFGL+K + + GT+ Y Sbjct: 192 GLDHLH---SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEK--KAYSFCGTVEY 246 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +APE+ +R G S+ +D +S+G+L+ EM++G Sbjct: 247 MAPEVVNRQ--GHSHSADWWSYGVLMFEMLTG 276 Score = 50.8 bits (120), Expect = 4e-06 Identities = 41/148 (27%), Positives = 72/148 (48%), Gaps = 10/148 (6%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNIL-LDYNFNP---KISDFGLAKLCARDQSILTLTAARGT 511 +EY H +Q ++H D+KP NIL +D + NP +I DFG AK + +L T Sbjct: 540 VEYLH---SQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY--T 594 Query: 510 MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKV- 334 ++APE+ R G D++S G+L+ M++G P + PE I ++ Sbjct: 595 ANFVAPEVLKRQ--GYDEGCDIWSLGVLLYTMLAG---CTPFANGPSDT--PEEILTRIG 647 Query: 333 -----ISGHDWELTLEMTAEDKEKMMQL 265 ++G +W+ ++ + KM+ + Sbjct: 648 GGKFSVNGGNWDTISDVAKDLVSKMLHV 675
>RIPK5_XENTR (Q67E00) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 918 Score = 55.8 bits (133), Expect = 1e-07 Identities = 52/173 (30%), Positives = 71/173 (41%), Gaps = 2/173 (1%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ + H NQ ++H DIK N+LLD KI+D G K A + GT + Sbjct: 755 GIRFLH---NQGLVHRDIKLKNVLLDKKHRAKITDLGFCKPEAMMSGSIV-----GTPIH 806 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH 322 +APEL+S G DVY+FG+L + SG V LPE + H Sbjct: 807 MAPELFS---GKYDNSVDVYAFGILFWYICSG------------SVKLPEAFEKCASKDH 851 Query: 321 DWELTLEMTAEDKEKMMQLTIVGLWSIQWN--PKNRPSMTKVVNMLTGRLQNL 169 W + ++ + L WN P RP M V ML G + L Sbjct: 852 LWNNVRKGARPERLAIFDEECWKLMEACWNGDPSQRPLMGIVQPMLQGIMDRL 904
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 55.8 bits (133), Expect = 1e-07 Identities = 29/91 (31%), Positives = 53/91 (58%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 +EY H + I+H D+KP NILL+ + + +I+DFG AK+ + + + GT Y+ Sbjct: 193 LEYLH---GKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYV 249 Query: 498 APELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +PEL + SD+++ G ++ ++V+G Sbjct: 250 SPELLTEK--SACKSSDLWALGCIIYQLVAG 278
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 55.8 bits (133), Expect = 1e-07 Identities = 32/93 (34%), Positives = 54/93 (58%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+EY H N I+H DIK NIL+D +++DFG +K ++ + +GT + Sbjct: 183 GLEYLH---NNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYW 239 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 +APE+ + G S+ +D++S G V+EM +G+ Sbjct: 240 MAPEVILQT--GHSFSADIWSVGCTVIEMATGK 270
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 55.8 bits (133), Expect = 1e-07 Identities = 29/91 (31%), Positives = 53/91 (58%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 +EY H + I+H D+KP NILL+ + + +I+DFG AK+ + + + GT Y+ Sbjct: 196 LEYLH---GKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYV 252 Query: 498 APELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +PEL + SD+++ G ++ ++V+G Sbjct: 253 SPELLTEK--SACKSSDLWALGCIIYQLVAG 281
>TSSK2_HUMAN (Q96PF2) Testis-specific serine/threonine-protein kinase 2 (EC| 2.7.11.1) (TSSK-2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G) Length = 358 Score = 55.8 bits (133), Expect = 1e-07 Identities = 34/92 (36%), Positives = 51/92 (55%), Gaps = 5/92 (5%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQS--ILTLTAARGTMGYIAPELYSRNF 472 I+H D+K N+LLD +FN K+SDFG +K C RD + I+ G+ Y APE+ Sbjct: 132 IVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQ--- 188 Query: 471 GGVSYKS---DVYSFGMLVLEMVSGRRNSDPS 385 + Y+ D++S G+++ MV G D S Sbjct: 189 -SIPYQPKVYDIWSLGVILYIMVCGSMPYDDS 219
>KCC4_YEAST (P25389) Probable serine/threonine-protein kinase KCC4 (EC| 2.7.11.1) Length = 1037 Score = 55.8 bits (133), Expect = 1e-07 Identities = 40/111 (36%), Positives = 62/111 (55%), Gaps = 3/111 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ Y H I+H D+KP N+LLD +N KI+DFG+A L D +L + G+ Y Sbjct: 139 GISYCHA---LGIVHRDLKPENLLLDSFYNIKIADFGMAAL-QTDADLLETSC--GSPHY 192 Query: 501 IAPELYSRNFGGVSYK---SDVYSFGMLVLEMVSGRRNSDPSVENQDEVYL 358 APE+ S G+ Y+ SDV+S G+++ +++GR D N ++ L Sbjct: 193 AAPEIVS----GLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLL 239
>MP2K2_XENLA (Q07192) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (MAPK-ERK kinase 2) (Fragment) Length = 446 Score = 55.8 bits (133), Expect = 1e-07 Identities = 34/86 (39%), Positives = 49/86 (56%), Gaps = 2/86 (2%) Frame = -2 Query: 654 NQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELY--S 481 N +I+H DIKP NILLD N N K+ DFG++ + + T G Y+APE S Sbjct: 269 NLKIIHRDIKPSNILLDTNGNIKLCDFGIS---GQLVDSIAKTRDAGCRPYMAPERIDPS 325 Query: 480 RNFGGVSYKSDVYSFGMLVLEMVSGR 403 + G +SDV+S G+ + E+ +GR Sbjct: 326 ASRQGYDVRSDVWSLGITLYELATGR 351
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 55.8 bits (133), Expect = 1e-07 Identities = 31/80 (38%), Positives = 48/80 (60%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 + H D+KP N+LLD N N K+SDFGL+ L +L T GT Y+APE+ S G Sbjct: 130 VYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLRTTC--GTPNYVAPEVLSGQ-GY 186 Query: 465 VSYKSDVYSFGMLVLEMVSG 406 +D++S G+++ +++G Sbjct: 187 DGSAADIWSCGVILFVILAG 206
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 55.8 bits (133), Expect = 1e-07 Identities = 33/92 (35%), Positives = 58/92 (63%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+++ H + I++ D+KP NILLD + K++DFGL+K + + GT+ Y Sbjct: 174 GLDHLH---SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEK--KAYSFCGTVEY 228 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +APE+ +R G S+ +D +S+G+L+ EM++G Sbjct: 229 MAPEVVNRQ--GHSHSADWWSYGVLMFEMLTG 258 Score = 51.6 bits (122), Expect = 2e-06 Identities = 42/144 (29%), Positives = 71/144 (49%), Gaps = 6/144 (4%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNIL-LDYNFNP---KISDFGLAKLCARDQSILTLTAARGT 511 +EY H +Q ++H D+KP NIL +D + NP +I DFG AK + +L T Sbjct: 523 VEYLH---SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCY--T 577 Query: 510 MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR--NSDPSVENQDEVYLPEWIYEK 337 ++APE+ R G D++S G+L+ M++G + PS + +E+ + Sbjct: 578 ANFVAPEVLKRQ--GYDEGCDIWSLGILLYTMLAGYTPFANGPS-DTPEEILTRIGSGKF 634 Query: 336 VISGHDWELTLEMTAEDKEKMMQL 265 +SG +W E + KM+ + Sbjct: 635 TLSGGNWNTVSETAKDLVSKMLHV 658
>MK14C_DROME (P83100) Putative mitogen-activated protein kinase 14C (EC| 2.7.11.24) (MAP kinase p38c) Length = 356 Score = 55.8 bits (133), Expect = 1e-07 Identities = 33/94 (35%), Positives = 54/94 (57%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG++Y H ++H D+KP NI ++ N +I DFGL+++CA +T GTM Sbjct: 133 RGLKYIHSA---GVVHRDLKPCNIAVNGNSEVRILDFGLSRMCAD-----KMTDHVGTMW 184 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y+APE+ G + DV+S G ++ E+++ R Sbjct: 185 YLAPEIIFLR-GQYTKAIDVWSVGCILAELITDR 217
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 55.5 bits (132), Expect = 2e-07 Identities = 45/150 (30%), Positives = 73/150 (48%), Gaps = 10/150 (6%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNIL-LDYNFNP---KISDFGLAKLCARDQSILTLTAAR 517 R M+Y H +Q ++H D+KP NIL +D + NP +I DFG AK + +L Sbjct: 518 RTMDYLH---SQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCY- 573 Query: 516 GTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEK 337 T ++APE+ R G DV+S G+L+ M++G P D+ PE I + Sbjct: 574 -TANFVAPEVLKRQ--GYDAACDVWSLGILLYTMLAG---FTPFANGPDDT--PEEILAR 625 Query: 336 V------ISGHDWELTLEMTAEDKEKMMQL 265 + +SG +W+ + + KM+ + Sbjct: 626 IGSGKYALSGGNWDSISDAAKDVVSKMLHV 655 Score = 55.1 bits (131), Expect = 2e-07 Identities = 33/81 (40%), Positives = 52/81 (64%), Gaps = 1/81 (1%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCA-RDQSILTLTAARGTMGYIAPELYSRNFG 469 I++ D+KP NILLD + KI+DFGL+K D+ + GT+ Y+APE+ +R Sbjct: 180 IIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYSFC---GTIEYMAPEVVNRR-- 234 Query: 468 GVSYKSDVYSFGMLVLEMVSG 406 G + +D +SFG+L+ EM++G Sbjct: 235 GHTQSADWWSFGVLMFEMLTG 255
>GRK2_CAEEL (Q09639) G protein-coupled receptor kinase 2 (EC 2.7.11.16)| Length = 707 Score = 55.5 bits (132), Expect = 2e-07 Identities = 37/94 (39%), Positives = 59/94 (62%), Gaps = 2/94 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+E+ H N+ +++ D+KP NILLD N + ++SD GLA C D S A+ GT GY Sbjct: 305 GLEHMH---NRFVVYRDLKPANILLDENGHVRVSDLGLA--C--DYSKKKPHASVGTHGY 357 Query: 501 IAPELYSRNFGGVSYKS--DVYSFGMLVLEMVSG 406 +APE+ ++ GV+Y S D +S G ++ +++ G Sbjct: 358 MAPEVLAK---GVAYDSSADWFSLGCMLYKLLKG 388
>PKNL_MYCTU (O53510) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 55.5 bits (132), Expect = 2e-07 Identities = 31/80 (38%), Positives = 48/80 (60%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 ++H D+KP NIL+ + + K++DFGL + A SI + GT Y++PE G Sbjct: 138 LVHRDVKPENILISDDGDVKLADFGLVRAVAA-ASITSTGVILGTAAYLSPE--QVRDGN 194 Query: 465 VSYKSDVYSFGMLVLEMVSG 406 +SDVYS G+LV E+++G Sbjct: 195 ADPRSDVYSVGVLVYELLTG 214
>PKNL_MYCBO (Q7TYY6) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 55.5 bits (132), Expect = 2e-07 Identities = 31/80 (38%), Positives = 48/80 (60%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 ++H D+KP NIL+ + + K++DFGL + A SI + GT Y++PE G Sbjct: 138 LVHRDVKPENILISDDGDVKLADFGLVRAVAA-ASITSTGVILGTAAYLSPE--QVRDGN 194 Query: 465 VSYKSDVYSFGMLVLEMVSG 406 +SDVYS G+LV E+++G Sbjct: 195 ADPRSDVYSVGVLVYELLTG 214
>RK_RAT (Q63651) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 564 Score = 55.5 bits (132), Expect = 2e-07 Identities = 37/107 (34%), Positives = 58/107 (54%), Gaps = 3/107 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+E+ HQ +RI++ D+KP N+LLD + N +ISD GLA Q+ GT G+ Sbjct: 304 GLEHLHQ---RRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQN--KTKGYAGTPGF 358 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR---RNSDPSVENQD 370 +APEL + D ++ G+ + EM++ R R VEN++ Sbjct: 359 MAPELLRGE--EYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKE 403
>RK_MOUSE (Q9WVL4) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 564 Score = 55.5 bits (132), Expect = 2e-07 Identities = 37/107 (34%), Positives = 58/107 (54%), Gaps = 3/107 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+E+ HQ +RI++ D+KP N+LLD + N +ISD GLA Q+ GT G+ Sbjct: 304 GLEHLHQ---RRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQN--KTKGYAGTPGF 358 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR---RNSDPSVENQD 370 +APEL + D ++ G+ + EM++ R R VEN++ Sbjct: 359 MAPELLRGE--EYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKE 403
>GRK6_HUMAN (P43250) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK6) Length = 576 Score = 55.5 bits (132), Expect = 2e-07 Identities = 34/93 (36%), Positives = 55/93 (59%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+E H+ +RI++ D+KP NILLD + + +ISD GLA Q T+ GT+GY Sbjct: 298 GLEDLHR---ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ---TIKGRVGTVGY 351 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 +APE+ ++ D ++ G L+ EM++G+ Sbjct: 352 MAPEVVKNE--RYTFSPDWWALGCLLYEMIAGQ 382
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 55.5 bits (132), Expect = 2e-07 Identities = 43/126 (34%), Positives = 65/126 (51%), Gaps = 19/126 (15%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y + + +H D++ N+L+ + KI+DFGLA++ D A+ + + Sbjct: 353 GMAYIER---KNYIHRDLRAANVLVSESLMCKIADFGLARVI-EDNEYTAREGAKFPIKW 408 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVS-------GRRNSD-----------PSVEN 376 APE NFG + KSDV+SFG+L+ E+V+ GR N+D P VEN Sbjct: 409 TAPEAI--NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVEN 466 Query: 375 -QDEVY 361 DE+Y Sbjct: 467 CPDELY 472
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 55.5 bits (132), Expect = 2e-07 Identities = 36/103 (34%), Positives = 56/103 (54%) Frame = -2 Query: 642 LHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGV 463 +H D++ NIL+ + KI+DFGLA+L D A+ + + APE N+G Sbjct: 360 IHRDLRAANILVSDTLSCKIADFGLARLI-EDNEYTAREGAKFPIKWTAPEAI--NYGTF 416 Query: 462 SYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKV 334 + KSDV+SFG+L+ E+V+ R P + N + + E Y V Sbjct: 417 TIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 459
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 55.5 bits (132), Expect = 2e-07 Identities = 36/103 (34%), Positives = 56/103 (54%) Frame = -2 Query: 642 LHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGV 463 +H D++ NIL+ + KI+DFGLA+L D A+ + + APE N+G Sbjct: 360 IHRDLRAANILVSDTLSCKIADFGLARLI-EDNEYTAREGAKFPIKWTAPEAI--NYGTF 416 Query: 462 SYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKV 334 + KSDV+SFG+L+ E+V+ R P + N + + E Y V Sbjct: 417 TIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 459
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 55.5 bits (132), Expect = 2e-07 Identities = 44/141 (31%), Positives = 78/141 (55%), Gaps = 8/141 (5%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTA-ARGTM 508 R +++ H+ +I+H DIKP NIL+ K++DFG+A+ A + + +T T GT Sbjct: 120 RALDHAHKN---KIIHRDIKPQNILVTDEDVVKVTDFGIAR--AANGATITYTGDVIGTA 174 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR----RNSDPSV---ENQDEVYLPEW 349 Y +PE + V ++D+YS G+++ EM++G+ +S SV Q+++ P Sbjct: 175 YYFSPEQAKGSI--VDERTDIYSLGIVLFEMLTGKVPFEGDSPISVALKHIQEDILPPSR 232 Query: 348 IYEKVISGHDWELTLEMTAED 286 + EKV D ++ L+ T +D Sbjct: 233 LNEKVPEELD-KIVLKATQKD 252
>SSK22_YEAST (P25390) Serine/threonine-protein kinase SSK22 (EC 2.7.11.1) (MAP| kinase kinase kinase SSK22) (Suppressor of sensor kinase 22) Length = 1331 Score = 55.5 bits (132), Expect = 2e-07 Identities = 40/109 (36%), Positives = 53/109 (48%), Gaps = 15/109 (13%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAA------ 520 G+ Y HQ ++H DIKP NILLD+N K DFG A+ ++ AA Sbjct: 1145 GLAYLHQS---GVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGV 1201 Query: 519 --------RGTMGYIAPELYSRN-FGGVSYKSDVYSFGMLVLEMVSGRR 400 GT Y+APE S + G DV++ G +VLEM +GRR Sbjct: 1202 ETKSLNEMMGTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRR 1250
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 55.5 bits (132), Expect = 2e-07 Identities = 37/106 (34%), Positives = 60/106 (56%), Gaps = 1/106 (0%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 ++Y H+ + ILH DIKP NI++ +N K++DFG + + + TL GT+ Y+ Sbjct: 220 LDYMHE---RNILHRDIKPENIIIGFNNTIKLTDFGWSVITPKGSKRKTLC---GTVDYL 273 Query: 498 APELY-SRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 +PEL SR + + K DV++ G+L E++ G S P E E+ Sbjct: 274 SPELIRSREY---NEKVDVWALGVLTYELLVG---SPPFEEESKEL 313
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 55.5 bits (132), Expect = 2e-07 Identities = 35/95 (36%), Positives = 53/95 (55%), Gaps = 1/95 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAA-RGTM 508 + +EY H+ I+H DIKP N++L N K+ DFG+A+ +T TAA GT Sbjct: 124 QALEYSHRA---GIVHRDIKPANVMLTRNGQVKVMDFGIARAMGDSGMTMTQTAAVIGTA 180 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y++PE V +SD+YS G L+ E+++ R Sbjct: 181 QYLSPE--QAKGEQVDARSDLYSTGCLLYELLTVR 213
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 55.5 bits (132), Expect = 2e-07 Identities = 47/162 (29%), Positives = 80/162 (49%), Gaps = 3/162 (1%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGT---M 508 MEY + + +H D+ N L+ N K++DFGL++L D T TA GT + Sbjct: 300 MEYLEK---KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGD----TYTAHAGTKFPI 352 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 + APE S + S KSDV++FG+L+ E+ + + P ++ +YE + Sbjct: 353 KWTAPE--SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-------VYELL-- 401 Query: 327 GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKV 202 + + +E EK+ +L + W QWNP +RP+ ++ Sbjct: 402 --EKDYRMERPEGCPEKVYEL-MRACW--QWNPSDRPAFAEI 438
>GRK1_CAEEL (Q09537) G protein-coupled receptor kinase 1 (EC 2.7.11.16)| Length = 642 Score = 55.5 bits (132), Expect = 2e-07 Identities = 35/93 (37%), Positives = 53/93 (56%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+++ H ++RIL+ D+KP NILLD + +ISD GLA ++ I GT+GY Sbjct: 315 GLQHLH---SERILYRDLKPENILLDDFGHVRISDLGLAVEIKDNEPI---KGRVGTVGY 368 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 +APE+ SY D + G L+ EM+ G+ Sbjct: 369 MAPEIVKNE--RYSYGVDWWGVGCLIYEMIEGK 399
>IPL1_DEBHA (Q6BVA0) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 412 Score = 55.1 bits (131), Expect = 2e-07 Identities = 47/161 (29%), Positives = 81/161 (50%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 ++Y H + I+H DIKP NILL + K+SDFG + S LT GT+ Y+ Sbjct: 259 LDYLH---TKHIIHRDIKPENILLSTDNCIKLSDFGWSVKSLPSSSTKRLTIC-GTLDYL 314 Query: 498 APELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGHD 319 PE+ N Y D++S G+L E + G+ P E D+ Y++ I+ D Sbjct: 315 PPEMIESN--EHDYTVDIWSLGILCYEFLVGK----PPFEEIDK----NSTYKR-IAKVD 363 Query: 318 WELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVN 196 ++ +++E + +++L +Q +PK R ++ +V+N Sbjct: 364 LKIPSFLSSEATDLILRL-------LQKSPKKRITLAEVMN 397
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 55.1 bits (131), Expect = 2e-07 Identities = 35/93 (37%), Positives = 55/93 (59%), Gaps = 1/93 (1%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSI-LTLTAARGTMG 505 G+E+ H ++ +LH DIK NILL + K++DFG CA+ + L T GT Sbjct: 726 GLEFLH---SKGVLHRDIKSDNILLSMEGDIKLTDFG---FCAQINELNLKRTTMVGTPY 779 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 ++APE+ SR G K D++S G++++EM+ G Sbjct: 780 WMAPEVVSRKEYGP--KVDIWSLGIMIIEMIEG 810
>GRK6_MOUSE (O70293) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK6) Length = 576 Score = 55.1 bits (131), Expect = 2e-07 Identities = 34/93 (36%), Positives = 55/93 (59%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+E H+ +RI++ D+KP NILLD + + +ISD GLA Q T+ GT+GY Sbjct: 298 GLEDLHR---ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ---TIKGRVGTVGY 351 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 +APE+ ++ D ++ G L+ EM++G+ Sbjct: 352 MAPEVVRNE--RYTFSPDWWALGCLLYEMIAGQ 382
>CDC2_AJECA (P54119) Cell division control protein 2 (EC 2.7.11.22) (EC| 2.7.11.23) (Cyclin-dependent protein kinase) Length = 324 Score = 55.1 bits (131), Expect = 2e-07 Identities = 39/109 (35%), Positives = 59/109 (54%), Gaps = 2/109 (1%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ Y H + R+LH D+KP N+L+D N K++DFGLA+ A + T T T+ Y Sbjct: 135 GIRYCH---SHRVLHRDLKPQNLLIDREGNLKLADFGLAR--AFGVPLRTYTHEVVTLWY 189 Query: 501 IAPELYSRNFGGVSYKS--DVYSFGMLVLEMVSGRRNSDPSVENQDEVY 361 APE+ GG Y + D++S G + EM + R+ P DE++ Sbjct: 190 RAPEIL---LGGRQYSTGVDMWSVGAIFAEMCT-RKPLFPGDSEIDEIF 234
>VGFR3_HUMAN (P35916) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1298 Score = 55.1 bits (131), Expect = 2e-07 Identities = 48/171 (28%), Positives = 88/171 (51%), Gaps = 1/171 (0%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RGME+ +++ +H D+ NILL + KI DFGLA+ +D + +AR + Sbjct: 1023 RGMEFL---ASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLK 1079 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 ++APE ++ + + + +SDV+SFG+L+ E+ S + P V+ +E +++ Sbjct: 1080 WMAPESIFDKVY---TTQSDVWSFGVLLWEIFSLGASPYPGVQINEE------FCQRLRD 1130 Query: 327 GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQ 175 G T E ++ ++ WS +PK RP+ +++V +L LQ Sbjct: 1131 G-----TRMRAPELATPAIRRIMLNCWS--GDPKARPAFSELVEILGDLLQ 1174
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 55.1 bits (131), Expect = 2e-07 Identities = 33/93 (35%), Positives = 53/93 (56%) Frame = -2 Query: 642 LHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGV 463 +H D++ NIL+ + KI+DFGLA+L D A+ + + APE N+G Sbjct: 360 IHRDLRAANILVSDTLSCKIADFGLARLI-EDNEYTAREGAKFPIKWTAPEAI--NYGTF 416 Query: 462 SYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV 364 + KSDV+SFG+L+ E+V+ R P + N + + Sbjct: 417 TIKSDVWSFGILMTEIVTHGRIPYPGMTNPEVI 449
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 55.1 bits (131), Expect = 2e-07 Identities = 52/174 (29%), Positives = 82/174 (47%), Gaps = 1/174 (0%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GMEY +++++H D+ NIL+ + K+SDFGLAK R L ++R + + Sbjct: 298 GMEYLE---SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAELRK----GLDSSRLPVKW 350 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH 322 APE G S KSDV+SFG+L+ E+ S R P + ++ + E V G+ Sbjct: 351 TAPEALKN--GRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKE-------VSEAVEKGY 401 Query: 321 DWELTLEMTAEDKEKMMQLTIVG-LWSIQWNPKNRPSMTKVVNMLTGRLQNLQI 163 M D T++G W + P RP K+V L L+++ + Sbjct: 402 ------RMEPPDSCPGPVHTLMGSCWEAE--PSRRPPFRKIVEKLGRELRSVGV 447
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 55.1 bits (131), Expect = 2e-07 Identities = 34/80 (42%), Positives = 53/80 (66%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 I++ D+KP NILLD + + K++DFGL+K A D T + GT+ Y+APE+ +R G Sbjct: 225 IVYRDLKPENILLDADGHIKVTDFGLSKE-AIDSEKKTYSFC-GTVEYMAPEVINRR--G 280 Query: 465 VSYKSDVYSFGMLVLEMVSG 406 S +D +S G+L+ EM++G Sbjct: 281 HSMAADFWSLGVLMFEMLTG 300
>ERKA_DROME (P40417) Mitogen-activated protein kinase ERK-A (EC 2.7.11.24)| (Extracellular-regulated kinase A) (Protein rolled) Length = 376 Score = 55.1 bits (131), Expect = 2e-07 Identities = 35/95 (36%), Positives = 52/95 (54%), Gaps = 1/95 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSIL-TLTAARGTM 508 RG++Y H +LH D+KP N+LL+ + KI DFGLA++ + LT T Sbjct: 148 RGLKYIHSA---NVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATR 204 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y APE+ N G + D++S G ++ EM+S R Sbjct: 205 WYRAPEI-MLNSKGYTKSIDIWSVGCILAEMLSNR 238
>KS6AB_XENLA (P10666) Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1)| (Ribosomal protein S6 kinase II beta) (S6KII-beta) (P90-RSK) Length = 629 Score = 55.1 bits (131), Expect = 2e-07 Identities = 33/92 (35%), Positives = 58/92 (63%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+++ H + I++ D+KP NILLD + K++DFGL+K + + GT+ Y Sbjct: 174 GLDHLH---SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEK--KAYSFCGTVEY 228 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +APE+ +R G S+ +D +S+G+L+ EM++G Sbjct: 229 MAPEVVNRQ--GHSHGADWWSYGVLMFEMLTG 258 Score = 45.8 bits (107), Expect = 1e-04 Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 4/95 (4%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNIL-LDYNFNP---KISDFGLAKLCARDQSILTLTAARGT 511 +EY H +Q ++H D+KP NIL +D + +P +I DFG +K + +L T Sbjct: 521 VEYLH---SQGVVHRDLKPSNILYVDESGDPESIRICDFGFSKQLRAENGLLMTPCY--T 575 Query: 510 MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 ++APE+ R G D++S G+L+ M++G Sbjct: 576 ANFVAPEVLKRQ--GYDEGCDIWSLGILLYTMLAG 608
>LRRK2_HUMAN (Q5S007) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) (Dardarin) Length = 2527 Score = 55.1 bits (131), Expect = 2e-07 Identities = 35/99 (35%), Positives = 58/99 (58%), Gaps = 8/99 (8%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNP------KISDFGLAKLCARDQSILTLTAA 520 G+ Y H I++ D+KPHN+LL + P KI+D+G+A+ C R + + + Sbjct: 1981 GLRYLHSAM---IIYRDLKPHNVLL-FTLYPNAAIIAKIADYGIAQYCCR----MGIKTS 2032 Query: 519 RGTMGYIAPELYSRNFGGVSY--KSDVYSFGMLVLEMVS 409 GT G+ APE+ G V Y ++DVYSFG+L+ ++++ Sbjct: 2033 EGTPGFRAPEVAR---GNVIYNQQADVYSFGLLLYDILT 2068
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 54.7 bits (130), Expect = 3e-07 Identities = 35/92 (38%), Positives = 57/92 (61%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y H +I+H D+K N+L+ Y+ KISDFG +K + D+S T + GT+ + Sbjct: 256 GMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSKELS-DKS--TKMSFAGTVAW 309 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +APE+ VS K D++SFG+++ E+++G Sbjct: 310 MAPEVIRNE--PVSEKVDIWSFGVVLWELLTG 339
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 54.7 bits (130), Expect = 3e-07 Identities = 35/92 (38%), Positives = 57/92 (61%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y H +I+H D+K N+L+ Y+ KISDFG +K + D+S T + GT+ + Sbjct: 256 GMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSKELS-DKS--TKMSFAGTVAW 309 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +APE+ VS K D++SFG+++ E+++G Sbjct: 310 MAPEVIRNE--PVSEKVDIWSFGVVLWELLTG 339
>M3K5_HUMAN (Q99683) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1374 Score = 54.7 bits (130), Expect = 3e-07 Identities = 34/95 (35%), Positives = 56/95 (58%), Gaps = 2/95 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLD-YNFNPKISDFGLAK-LCARDQSILTLTAARGTM 508 G++Y H + +I+H DIK N+L++ Y+ KISDFG +K L + T T GT+ Sbjct: 790 GLKYLH---DNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT---GTL 843 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y+APE+ + G +D++S G ++EM +G+ Sbjct: 844 QYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGK 878
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 54.7 bits (130), Expect = 3e-07 Identities = 33/81 (40%), Positives = 52/81 (64%), Gaps = 1/81 (1%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAK-LCARDQSILTLTAARGTMGYIAPELYSRNFG 469 I++ D+KP NILLD + KI+DFGL+K D+ + GT+ Y+APE+ +R Sbjct: 180 IIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFC---GTIEYMAPEVVNRR-- 234 Query: 468 GVSYKSDVYSFGMLVLEMVSG 406 G + +D +SFG+L+ EM++G Sbjct: 235 GHTQSADWWSFGVLMFEMLTG 255 Score = 49.3 bits (116), Expect = 1e-05 Identities = 41/148 (27%), Positives = 70/148 (47%), Gaps = 10/148 (6%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILL-DYNFNP---KISDFGLAKLCARDQSILTLTAARGT 511 M+Y H +Q ++H D+KP NIL D + +P ++ DFG AK +L T Sbjct: 520 MDYLH---SQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCY--T 574 Query: 510 MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKV- 334 ++APE+ R G D++S G+L+ M++G P D+ PE I ++ Sbjct: 575 ANFVAPEVLKRQ--GYDAACDIWSLGILLYTMLAG---FTPFANGPDDT--PEEILARIG 627 Query: 333 -----ISGHDWELTLEMTAEDKEKMMQL 265 +SG +W+ + + KM+ + Sbjct: 628 SGKYALSGGNWDSISDAAKDVVSKMLHV 655
>KPCG_RAT (P63319) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 54.7 bits (130), Expect = 3e-07 Identities = 41/118 (34%), Positives = 65/118 (55%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ + H NQ I++ D+K N++LD + KI+DFG+ K S T GT Y Sbjct: 467 GLFFLH---NQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGS--TTRTFCGTPDY 521 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 IAPE+ + G S D +SFG+L+ EM++G+ P + +DE L + I E+ ++ Sbjct: 522 IAPEIIAYQPYGKSV--DWWSFGVLLYEMLAGQ----PPFDGEDEEELFQAIMEQTVT 573
>KPCG_MOUSE (P63318) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 54.7 bits (130), Expect = 3e-07 Identities = 41/118 (34%), Positives = 65/118 (55%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ + H NQ I++ D+K N++LD + KI+DFG+ K S T GT Y Sbjct: 467 GLFFLH---NQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGS--TTRTFCGTPDY 521 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 IAPE+ + G S D +SFG+L+ EM++G+ P + +DE L + I E+ ++ Sbjct: 522 IAPEIIAYQPYGKSV--DWWSFGVLLYEMLAGQ----PPFDGEDEEELFQAIMEQTVT 573
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 54.7 bits (130), Expect = 3e-07 Identities = 47/162 (29%), Positives = 79/162 (48%), Gaps = 3/162 (1%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGT---M 508 MEY + + +H D+ N L+ N K++DFGL++L D T TA G + Sbjct: 237 MEYLEK---KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGD----TYTAHAGAKFPI 289 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 + APE S + S KSDV++FG+L+ E+ + + P ++ +YE + Sbjct: 290 KWTAPE--SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-------VYELL-- 338 Query: 327 GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKV 202 + + +E EK+ +L + W QWNP +RPS ++ Sbjct: 339 --EKDYRMERPEGCPEKVYEL-MRACW--QWNPSDRPSFAEI 375
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 54.7 bits (130), Expect = 3e-07 Identities = 37/104 (35%), Positives = 57/104 (54%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y +Q +H D+ N+L+ KI+DFGLA+L D+ + AR + + Sbjct: 357 GMAYLE---SQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARV-GARFPIKW 412 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQD 370 APE + N+ S KSDV+SFG+L+ E+V+ R P + N + Sbjct: 413 TAPE--AANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAE 454
>KPCG_BOVIN (P05128) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| (Fragment) Length = 682 Score = 54.7 bits (130), Expect = 3e-07 Identities = 41/118 (34%), Positives = 65/118 (55%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ + H NQ I++ D+K N++LD + KI+DFG+ K S T GT Y Sbjct: 452 GLFFLH---NQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGS--TTRTFCGTPDY 506 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 IAPE+ + G S D +SFG+L+ EM++G+ P + +DE L + I E+ ++ Sbjct: 507 IAPEIIAYQPYGKSV--DWWSFGVLLYEMLAGQ----PPFDGEDEEELFQAIMEQTVT 558
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 54.7 bits (130), Expect = 3e-07 Identities = 47/162 (29%), Positives = 79/162 (48%), Gaps = 3/162 (1%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGT---M 508 MEY + + +H D+ N L+ N K++DFGL++L D T TA G + Sbjct: 351 MEYLEK---KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGD----TYTAHAGAKFPI 403 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 + APE S + S KSDV++FG+L+ E+ + + P ++ +YE + Sbjct: 404 KWTAPE--SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-------VYELL-- 452 Query: 327 GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKV 202 + + +E EK+ +L + W QWNP +RPS ++ Sbjct: 453 --EKDYRMERPEGCPEKVYEL-MRACW--QWNPSDRPSFAEI 489
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 54.7 bits (130), Expect = 3e-07 Identities = 47/162 (29%), Positives = 79/162 (48%), Gaps = 3/162 (1%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGT---M 508 MEY + + +H D+ N L+ N K++DFGL++L D T TA G + Sbjct: 351 MEYLEK---KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGD----TYTAHAGAKFPI 403 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVIS 328 + APE S + S KSDV++FG+L+ E+ + + P ++ +YE + Sbjct: 404 KWTAPE--SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ-------VYELL-- 452 Query: 327 GHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKV 202 + + +E EK+ +L + W QWNP +RPS ++ Sbjct: 453 --EKDYRMERPEGCPEKVYEL-MRACW--QWNPSDRPSFAEI 489
>M3K5_MOUSE (O35099) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1380 Score = 54.7 bits (130), Expect = 3e-07 Identities = 34/95 (35%), Positives = 56/95 (58%), Gaps = 2/95 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLD-YNFNPKISDFGLAK-LCARDQSILTLTAARGTM 508 G++Y H + +I+H DIK N+L++ Y+ KISDFG +K L + T T GT+ Sbjct: 797 GLKYLH---DNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT---GTL 850 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y+APE+ + G +D++S G ++EM +G+ Sbjct: 851 QYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGK 885
>SHK1_SCHPO (P50527) Serine/threonine-protein kinase pak1/shk1 (EC 2.7.11.1)| Length = 658 Score = 54.7 bits (130), Expect = 3e-07 Identities = 35/93 (37%), Positives = 55/93 (59%), Gaps = 1/93 (1%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCAR-DQSILTLTAARGTMG 505 G+++ H+ I+H DIK NILL + K++DFG CA+ D ++ T GT Sbjct: 492 GLQHLHEN---GIVHRDIKSDNILLSLQGDIKLTDFG---FCAQIDSNMTKRTTMVGTPY 545 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 ++APE+ +R G +K DV+S G++ +EMV G Sbjct: 546 WMAPEVVTRKEYG--FKVDVWSLGIMAIEMVEG 576
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 54.7 bits (130), Expect = 3e-07 Identities = 44/163 (26%), Positives = 83/163 (50%), Gaps = 8/163 (4%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 ++Y H+ ++H D+KP N+LLD + N KI+DFGL+ + + + + T + G+ Y Sbjct: 127 VDYCHR---HMVVHRDLKPENVLLDAHMNAKIADFGLSNIMSDGEFLRT---SCGSPNYA 180 Query: 498 APELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSD----PSVENQ---DEVYLPEWIY 343 APE+ S R + G + D++S G+++ ++ G D P++ + Y+PE++ Sbjct: 181 APEVISGRLYAGP--EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 238 Query: 342 EKVISGHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPS 214 V TL M + + + TI + +W ++ PS Sbjct: 239 RSV-------ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 54.7 bits (130), Expect = 3e-07 Identities = 44/163 (26%), Positives = 83/163 (50%), Gaps = 8/163 (4%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 ++Y H+ ++H D+KP N+LLD + N KI+DFGL+ + + + + T + G+ Y Sbjct: 127 VDYCHR---HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNYA 180 Query: 498 APELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSD----PSVENQ---DEVYLPEWIY 343 APE+ S R + G + D++S G+++ ++ G D P++ + Y+PE++ Sbjct: 181 APEVISGRLYAGP--EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 238 Query: 342 EKVISGHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPS 214 V TL M + + + TI + +W ++ PS Sbjct: 239 RSV-------ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274
>STE7_CANAL (P46599) Serine/threonine-protein kinase STE7 homolog (EC 2.7.12.2)| Length = 589 Score = 54.7 bits (130), Expect = 3e-07 Identities = 35/117 (29%), Positives = 63/117 (53%), Gaps = 9/117 (7%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+ Y + +I+H DIKP+N+L+ + K+ DFG+++ S+ GT Y Sbjct: 360 GLTYLYT--THKIIHRDIKPNNVLMTHKGEFKLCDFGVSR--ELTNSLAMADTFVGTSMY 415 Query: 501 IAPELYSRNFGGVSY--KSDVYSFGMLVLEMVSG-------RRNSDPSVENQDEVYL 358 ++PE G+ Y KSDV+S G++++E+ SG N+D +++D+ Y+ Sbjct: 416 MSPE----RIQGLDYGVKSDVWSTGLMLIELASGVPVWSEDDNNNDDDEDDEDDAYV 468
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 54.7 bits (130), Expect = 3e-07 Identities = 35/92 (38%), Positives = 57/92 (61%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y H +I+H D+K N+L+ Y+ KISDFG +K + D+S T + GT+ + Sbjct: 223 GMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSKELS-DKS--TKMSFAGTVAW 276 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +APE+ VS K D++SFG+++ E+++G Sbjct: 277 MAPEVIRNE--PVSEKVDIWSFGVVLWELLTG 306
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 54.7 bits (130), Expect = 3e-07 Identities = 36/105 (34%), Positives = 57/105 (54%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RGM Y + +H D++ NIL+ KI+DFGLA+L D A+ + Sbjct: 375 RGMAYIER---MNYIHRDLRSANILVGNGLICKIADFGLARLI-EDNEYTARQGAKFPIK 430 Query: 504 YIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQD 370 + APE + +G + KSDV+SFG+L+ E+V+ R P + N++ Sbjct: 431 WTAPE--AALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNRE 473
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 54.7 bits (130), Expect = 3e-07 Identities = 48/173 (27%), Positives = 80/173 (46%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y ++ +H D+ N L+ N K++DFGLA+L RD + A+ + + Sbjct: 479 GMSYLE---SRNYIHRDLAARNCLVGDNKLVKVADFGLARL-MRDDTYTAHAGAKFPIKW 534 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH 322 APE + N S KSDV++FG+L+ E+ + + P+++ D +Y K+ G+ Sbjct: 535 TAPEGLAYN--KFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTD-------VYHKLDKGY 585 Query: 321 DWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVVNMLTGRLQNLQI 163 E E + M Q W QW+ +RP+ + + L Q I Sbjct: 586 RMERPPGCPPEVYDLMRQ-----CW--QWDATDRPTFKSIHHALEHMFQESSI 631
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 54.7 bits (130), Expect = 3e-07 Identities = 32/92 (34%), Positives = 58/92 (63%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+++ H + I++ D+KP NILLD + K++DFGL+K + + GT+ Y Sbjct: 174 GLDHLH---SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEK--KAYSFCGTVEY 228 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +APE+ +R G ++ +D +S+G+L+ EM++G Sbjct: 229 MAPEVVNRQ--GHTHSADWWSYGVLMFEMLTG 258 Score = 51.2 bits (121), Expect = 3e-06 Identities = 42/144 (29%), Positives = 71/144 (49%), Gaps = 6/144 (4%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNIL-LDYNFNP---KISDFGLAKLCARDQSILTLTAARGT 511 +EY H +Q ++H D+KP NIL +D + NP +I DFG AK + +L T Sbjct: 523 VEYLH---SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCY--T 577 Query: 510 MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRR--NSDPSVENQDEVYLPEWIYEK 337 ++APE+ R G D++S G+L+ M++G + PS + +E+ + Sbjct: 578 ANFVAPEVLKRQ--GYDEGCDIWSLGVLLYTMLAGYTPFANGPS-DTPEEILTRISSGKF 634 Query: 336 VISGHDWELTLEMTAEDKEKMMQL 265 +SG +W E + KM+ + Sbjct: 635 TLSGGNWNTVSETAKDLVSKMLHV 658
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 54.3 bits (129), Expect = 3e-07 Identities = 39/126 (30%), Positives = 72/126 (57%), Gaps = 8/126 (6%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G++Y H+ ++H D+KP N+LLD + N KI+DFGL+ + + + + T + G+ Y Sbjct: 128 GVDYCHR---HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNY 181 Query: 501 IAPELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSD----PSVENQ--DEV-YLPEWI 346 APE+ S R + G + D++S G+++ ++ G D P++ + D + Y P+++ Sbjct: 182 AAPEVISGRLYAGP--EVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL 239 Query: 345 YEKVIS 328 VIS Sbjct: 240 NPSVIS 245
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 54.3 bits (129), Expect = 3e-07 Identities = 39/126 (30%), Positives = 72/126 (57%), Gaps = 8/126 (6%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G++Y H+ ++H D+KP N+LLD + N KI+DFGL+ + + + + T + G+ Y Sbjct: 128 GVDYCHR---HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNY 181 Query: 501 IAPELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSD----PSVENQ--DEV-YLPEWI 346 APE+ S R + G + D++S G+++ ++ G D P++ + D + Y P+++ Sbjct: 182 AAPEVISGRLYAGP--EVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL 239 Query: 345 YEKVIS 328 VIS Sbjct: 240 NPSVIS 245
>STE20_CANAL (Q92212) Serine/threonine-protein kinase STE20 homolog (EC 2.7.11.1)| Length = 1230 Score = 54.3 bits (129), Expect = 3e-07 Identities = 35/94 (37%), Positives = 57/94 (60%), Gaps = 1/94 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAAR-GTM 508 +G+++ H ++ ++H DIK NILL+ + N KI+DFG CA+ I + GT Sbjct: 1059 KGLKFLH---SKGVIHRDIKSDNILLNMDGNIKITDFG---FCAQINEINSKRITMVGTP 1112 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 ++APE+ SR G K DV+S G++++EM+ G Sbjct: 1113 YWMAPEIVSRKEYGP--KVDVWSLGIMIIEMLEG 1144
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 54.3 bits (129), Expect = 3e-07 Identities = 31/94 (32%), Positives = 55/94 (58%), Gaps = 1/94 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L KI DFGLA + R L G++ Sbjct: 415 QGMDYLHA---KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVL 471 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 ++A E + ++ S++SDVY++G+++ E+++G Sbjct: 472 WMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTG 505
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 54.3 bits (129), Expect = 3e-07 Identities = 31/94 (32%), Positives = 55/94 (58%), Gaps = 1/94 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L KI DFGLA + R L G++ Sbjct: 415 QGMDYLHA---KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVL 471 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 ++A E + ++ S++SDVY++G+++ E+++G Sbjct: 472 WMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTG 505
>MK03_HUMAN (P27361) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) Length = 379 Score = 54.3 bits (129), Expect = 3e-07 Identities = 34/95 (35%), Positives = 52/95 (54%), Gaps = 1/95 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSIL-TLTAARGTM 508 RG++Y H +LH D+KP N+L++ + KI DFGLA++ + LT T Sbjct: 152 RGLKYIHSA---NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y APE+ N G + D++S G ++ EM+S R Sbjct: 209 WYRAPEI-MLNSKGYTKSIDIWSVGCILAEMLSNR 242
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 54.3 bits (129), Expect = 3e-07 Identities = 42/126 (33%), Positives = 65/126 (51%), Gaps = 19/126 (15%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y + + +H D++ N+L+ + KI+DFGLA++ D A+ + + Sbjct: 353 GMAYIER---KNYIHRDLRAANVLVSESLMCKIADFGLARVI-EDNEYTAREGAKFPIKW 408 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVS-------GRRNSD-----------PSVEN 376 APE NFG + KSDV+SFG+L+ E+V+ GR N+D P +EN Sbjct: 409 TAPEAI--NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRMEN 466 Query: 375 -QDEVY 361 DE+Y Sbjct: 467 CPDELY 472
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 54.3 bits (129), Expect = 3e-07 Identities = 42/126 (33%), Positives = 65/126 (51%), Gaps = 19/126 (15%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y + + +H D++ N+L+ + KI+DFGLA++ D A+ + + Sbjct: 353 GMAYIER---KNYIHRDLRAANVLVSESLMCKIADFGLARVI-EDNEYTAREGAKFPIKW 408 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVS-------GRRNSD-----------PSVEN 376 APE NFG + KSDV+SFG+L+ E+V+ GR N+D P +EN Sbjct: 409 TAPEAI--NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRMEN 466 Query: 375 -QDEVY 361 DE+Y Sbjct: 467 CPDELY 472
>GPRK2_DROME (P32866) G protein-coupled receptor kinase 2 (EC 2.7.11.16)| Length = 714 Score = 54.3 bits (129), Expect = 3e-07 Identities = 33/93 (35%), Positives = 53/93 (56%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+++ H+ Q I++ D KP NILLD + + +ISD GLA + + GT+GY Sbjct: 422 GLQHLHK---QGIVYRDCKPENILLDDHGHVRISDLGLAVEIPEGEMV---RGRVGTVGY 475 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 +APE+ ++ D +SFG L+ EM+ G+ Sbjct: 476 MAPEVIDNE--KYAFSPDWFSFGCLLYEMIEGQ 506
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 54.3 bits (129), Expect = 3e-07 Identities = 44/163 (26%), Positives = 82/163 (50%), Gaps = 8/163 (4%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 ++Y H+ ++H D+KP N+LLD N KI+DFGL+ + + + + T + G+ Y Sbjct: 127 VDYCHR---HMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRT---SCGSPNYA 180 Query: 498 APELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSD----PSVENQ---DEVYLPEWIY 343 APE+ S R + G + D++S G+++ ++ G D P++ + Y+PE++ Sbjct: 181 APEVISGRLYAGP--EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 238 Query: 342 EKVISGHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPS 214 V TL M + + + TI + +W ++ PS Sbjct: 239 RSV-------ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274
>MK03_RAT (P21708) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) (MNK1) Length = 380 Score = 54.3 bits (129), Expect = 3e-07 Identities = 34/95 (35%), Positives = 52/95 (54%), Gaps = 1/95 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSIL-TLTAARGTM 508 RG++Y H +LH D+KP N+L++ + KI DFGLA++ + LT T Sbjct: 153 RGLKYIHSA---NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 209 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y APE+ N G + D++S G ++ EM+S R Sbjct: 210 WYRAPEI-MLNSKGYTKSIDIWSVGCILAEMLSNR 243
>MK03_MOUSE (Q63844) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) (MNK1) Length = 380 Score = 54.3 bits (129), Expect = 3e-07 Identities = 34/95 (35%), Positives = 52/95 (54%), Gaps = 1/95 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSIL-TLTAARGTM 508 RG++Y H +LH D+KP N+L++ + KI DFGLA++ + LT T Sbjct: 153 RGLKYIHSA---NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 209 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y APE+ N G + D++S G ++ EM+S R Sbjct: 210 WYRAPEI-MLNSKGYTKSIDIWSVGCILAEMLSNR 243
>GRK7_SPETR (Q9Z2G7) G protein-coupled receptor kinase 7 precursor (EC| 2.7.11.16) (G protein-coupled receptor kinase GRK7) Length = 548 Score = 54.3 bits (129), Expect = 3e-07 Identities = 39/115 (33%), Positives = 57/115 (49%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 I++ D+KP N+LLD N ++SD GLA D+ I T GT GY+APE+ + Sbjct: 307 IVYRDLKPENVLLDDLGNCRLSDLGLAVEVQDDKPI---TQRAGTNGYMAPEIL-MDKAS 362 Query: 465 VSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGHDWELTLE 301 SY D ++ G + EMV+GR E + L E + ++ H T E Sbjct: 363 YSYPVDWFAMGCSIYEMVAGRTPFKDFKEKVSKEDLKERTMKDEVAFHHENFTEE 417
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 54.3 bits (129), Expect = 3e-07 Identities = 31/94 (32%), Positives = 55/94 (58%), Gaps = 1/94 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L KI DFGLA + R L G++ Sbjct: 413 QGMDYLHA---KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVL 469 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 ++A E + ++ S++SDVY++G+++ E+++G Sbjct: 470 WMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTG 503
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 54.3 bits (129), Expect = 3e-07 Identities = 31/94 (32%), Positives = 55/94 (58%), Gaps = 1/94 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 +GM+Y H + I+H D+K +NI L KI DFGLA + R L G++ Sbjct: 413 QGMDYLHA---KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVL 469 Query: 504 YIAPE-LYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 ++A E + ++ S++SDVY++G+++ E+++G Sbjct: 470 WMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTG 503
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 54.3 bits (129), Expect = 3e-07 Identities = 39/126 (30%), Positives = 72/126 (57%), Gaps = 8/126 (6%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G++Y H+ ++H D+KP N+LLD + N KI+DFGL+ + + + + T + G+ Y Sbjct: 126 GVDYCHR---HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNY 179 Query: 501 IAPELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSD----PSVENQ--DEV-YLPEWI 346 APE+ S R + G + D++S G+++ ++ G D P++ + D + Y P+++ Sbjct: 180 AAPEVISGRLYAGP--EVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL 237 Query: 345 YEKVIS 328 VIS Sbjct: 238 NPSVIS 243
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 54.3 bits (129), Expect = 3e-07 Identities = 39/126 (30%), Positives = 72/126 (57%), Gaps = 8/126 (6%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G++Y H+ ++H D+KP N+LLD + N KI+DFGL+ + + + + T + G+ Y Sbjct: 126 GVDYCHR---HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNY 179 Query: 501 IAPELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSD----PSVENQ--DEV-YLPEWI 346 APE+ S R + G + D++S G+++ ++ G D P++ + D + Y P+++ Sbjct: 180 AAPEVISGRLYAGP--EVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL 237 Query: 345 YEKVIS 328 VIS Sbjct: 238 NPSVIS 243
>SWE1_YEAST (P32944) Mitosis inhibitor protein kinase SWE1 (EC 2.7.11.1)| Length = 819 Score = 54.3 bits (129), Expect = 3e-07 Identities = 30/91 (32%), Positives = 52/91 (57%), Gaps = 1/91 (1%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLA-KLCARDQSILTLTAARGTMGY 502 + + H C+ I+H D+KP N+++ + N K+ DFG+A L D+S G Y Sbjct: 566 LRFIHDSCH--IVHLDLKPANVMITFEGNLKLGDFGMATHLPLEDKSF----ENEGDREY 619 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 409 IAPE+ S YK+D++S G++++E+ + Sbjct: 620 IAPEIISD--CTYDYKADIFSLGLMIVEIAA 648
>SUR1_CAEEL (P39745) Mitogen-activated protein kinase mpk-1 (EC 2.7.11.24) (MAP| kinase sur-1) Length = 444 Score = 54.3 bits (129), Expect = 3e-07 Identities = 36/95 (37%), Positives = 52/95 (54%), Gaps = 1/95 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLC-ARDQSILTLTAARGTM 508 RG++Y H +LH D+KP N+LL+ + KI DFGLA++ + LT T Sbjct: 206 RGLKYIHSA---NVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTEYVATR 262 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y APE+ N G + DV+S G ++ EM+S R Sbjct: 263 WYRAPEI-MLNSKGYTKSIDVWSVGCILAEMLSNR 296
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 53.9 bits (128), Expect = 4e-07 Identities = 45/161 (27%), Positives = 86/161 (53%), Gaps = 1/161 (0%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 +EY H+ +I+H D+KP N+LLD N KI+DFGL+ + + T + G+ Y Sbjct: 162 VEYCHR---HKIVHRDLKPENLLLDDQLNVKIADFGLSNIMTDGNFLKT---SCGSPNYA 215 Query: 498 APELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH 322 APE+ S + + G + DV+S G+++ M+ GR D+ ++P +++K+ +G Sbjct: 216 APEVISGKLYAGP--EVDVWSSGVILYVMLCGRLPF-------DDEFIPA-LFKKISNG- 264 Query: 321 DWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPSMTKVV 199 + L ++ K + ++ +V NP NR ++ +++ Sbjct: 265 VYTLPNYLSPGAKHLLTRMLVV-------NPLNRITIHEIM 298
>CDC28_CANAL (P43063) Cell division control protein 28 (EC 2.7.11.22)| Length = 317 Score = 53.9 bits (128), Expect = 4e-07 Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 2/110 (1%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 RG+++ H + R+LH D+KP N+L+D N K++DFGLA+ A + T T+ Sbjct: 119 RGIKHCH---SHRVLHRDLKPQNLLIDKEGNLKLADFGLAR--AFGVPLRAYTHEVVTLW 173 Query: 504 YIAPELYSRNFGGVSYKS--DVYSFGMLVLEMVSGRRNSDPSVENQDEVY 361 Y APE+ GG Y + D++S G + EM + R+ P DE++ Sbjct: 174 YRAPEIL---LGGKQYSTGVDMWSVGCIFAEMCN-RKPLFPGDSEIDEIF 219
>PKNA_MYCTU (P65726) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 431 Score = 53.9 bits (128), Expect = 4e-07 Identities = 37/83 (44%), Positives = 49/83 (59%), Gaps = 1/83 (1%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTA-ARGTMGYIAPELYSRNFG 469 ++H D+KP NIL+ KI+DFG+AK A D + +T T GT YIAPE + Sbjct: 137 LVHRDVKPGNILITPTGQVKITDFGIAK--AVDAAPVTQTGMVMGTAQYIAPEQALGH-- 192 Query: 468 GVSYKSDVYSFGMLVLEMVSGRR 400 S SDVYS G++ E VSG+R Sbjct: 193 DASPASDVYSLGVVGYEAVSGKR 215
>PKNA_MYCBO (P65727) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 431 Score = 53.9 bits (128), Expect = 4e-07 Identities = 37/83 (44%), Positives = 49/83 (59%), Gaps = 1/83 (1%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTA-ARGTMGYIAPELYSRNFG 469 ++H D+KP NIL+ KI+DFG+AK A D + +T T GT YIAPE + Sbjct: 137 LVHRDVKPGNILITPTGQVKITDFGIAK--AVDAAPVTQTGMVMGTAQYIAPEQALGH-- 192 Query: 468 GVSYKSDVYSFGMLVLEMVSGRR 400 S SDVYS G++ E VSG+R Sbjct: 193 DASPASDVYSLGVVGYEAVSGKR 215
>MP2K4_HUMAN (P45985) Dual specificity mitogen-activated protein kinase kinase 4| (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1) Length = 399 Score = 53.9 bits (128), Expect = 4e-07 Identities = 33/86 (38%), Positives = 49/86 (56%), Gaps = 2/86 (2%) Frame = -2 Query: 654 NQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELY--S 481 N +I+H DIKP NILLD + N K+ DFG++ + + T G Y+APE S Sbjct: 222 NLKIIHRDIKPSNILLDRSGNIKLCDFGIS---GQLVDSIAKTRDAGCRPYMAPERIDPS 278 Query: 480 RNFGGVSYKSDVYSFGMLVLEMVSGR 403 + G +SDV+S G+ + E+ +GR Sbjct: 279 ASRQGYDVRSDVWSLGITLYELATGR 304
>FIN1_SCHPO (O13839) G2-specific protein kinase fin1 (EC 2.7.11.1)| Length = 722 Score = 53.9 bits (128), Expect = 4e-07 Identities = 32/79 (40%), Positives = 48/79 (60%) Frame = -2 Query: 651 QRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNF 472 Q +LH DIKP NI LD N + K+ DFGL+KL D + + + GT Y++PE+ + Sbjct: 145 QSVLHRDIKPANIFLDENNSVKLGDFGLSKLL--DNTRVFTQSYVGTPYYMSPEIIRSS- 201 Query: 471 GGVSYKSDVYSFGMLVLEM 415 S KSDV++ G ++ E+ Sbjct: 202 -PYSAKSDVWALGCVIFEI 219
>MP2K4_MOUSE (P47809) Dual specificity mitogen-activated protein kinase kinase 4| (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SE Length = 397 Score = 53.9 bits (128), Expect = 4e-07 Identities = 33/86 (38%), Positives = 49/86 (56%), Gaps = 2/86 (2%) Frame = -2 Query: 654 NQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELY--S 481 N +I+H DIKP NILLD + N K+ DFG++ + + T G Y+APE S Sbjct: 220 NLKIIHRDIKPSNILLDRSGNIKLCDFGIS---GQLVDSIAKTRDAGCRPYMAPERIDPS 276 Query: 480 RNFGGVSYKSDVYSFGMLVLEMVSGR 403 + G +SDV+S G+ + E+ +GR Sbjct: 277 ASRQGYDVRSDVWSLGITLYELATGR 302
>SNF1_SCHPO (O74536) SNF1-like protein kinase ssp2 (EC 2.7.11.1)| Length = 576 Score = 53.9 bits (128), Expect = 4e-07 Identities = 34/93 (36%), Positives = 56/93 (60%), Gaps = 1/93 (1%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 +EY H+ +I+H D+KP N+LLD N N KI+DFGL+ + + T + G+ Y Sbjct: 144 IEYCHR---HKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKT---SCGSPNYA 197 Query: 498 APELYS-RNFGGVSYKSDVYSFGMLVLEMVSGR 403 APE+ + + + G + DV+S G+++ M+ GR Sbjct: 198 APEVINGKLYAGP--EVDVWSCGIVLYVMLVGR 228
>GRK6_RAT (P97711) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK6) Length = 576 Score = 53.9 bits (128), Expect = 4e-07 Identities = 33/93 (35%), Positives = 54/93 (58%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+E H+ +RI++ D+KP NILLD + + +ISD GL Q T+ GT+GY Sbjct: 298 GLEDLHR---ERIVYRDLKPENILLDDHGHIRISDLGLTVHVPEGQ---TIKGRVGTVGY 351 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 +APE+ ++ D ++ G L+ EM++G+ Sbjct: 352 MAPEVVKNE--RYTFSPDWWALGCLLYEMIAGQ 382
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 53.9 bits (128), Expect = 4e-07 Identities = 34/98 (34%), Positives = 57/98 (58%), Gaps = 4/98 (4%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAAR---- 517 +G+EY H ++ I+H DIK NIL+D KISDFG++K + + AR Sbjct: 508 KGLEYLH---SRGIVHRDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGGARPSFQ 564 Query: 516 GTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 G+ ++APE+ + + K+D++S G LV+EM++ + Sbjct: 565 GSSFWMAPEVVKQTMH--TEKTDIWSLGCLVIEMLTSK 600
>CDC2_VIGUN (P52389) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 53.9 bits (128), Expect = 4e-07 Identities = 44/110 (40%), Positives = 61/110 (55%), Gaps = 3/110 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNP-KISDFGLAKLCARDQSILTLTAARGTMG 505 G+ Y H + R+LH D+KP N+L+D N K++DFGLA+ A + T T T+ Sbjct: 114 GIAYCH---SHRVLHRDLKPQNLLIDRRTNSLKLADFGLAR--AFGIPVRTFTHEVVTLW 168 Query: 504 YIAPE--LYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVY 361 Y APE L SR++ S DV+S G L EMV+ RR P DE++ Sbjct: 169 YRAPEILLGSRHY---STPVDVWSVGCLFAEMVN-RRPLFPGDSEIDELF 214
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 53.9 bits (128), Expect = 4e-07 Identities = 36/104 (34%), Positives = 57/104 (54%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y + +H D++ NIL+ N KI+DFGLA+L D A+ + + Sbjct: 373 GMAYIER---MNYIHRDLRAANILVGDNLVCKIADFGLARLI-EDNEYTARQGAKFPIKW 428 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQD 370 APE + +G + KSDV+SFG+L+ E+V+ R P + N++ Sbjct: 429 TAPE--AALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNRE 470
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 53.9 bits (128), Expect = 4e-07 Identities = 43/163 (26%), Positives = 82/163 (50%), Gaps = 8/163 (4%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 ++Y H+ ++H D+KP N+LLD N KI+DFGL+ + + + + T + G+ Y Sbjct: 127 VDYCHR---HMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRT---SCGSPNYA 180 Query: 498 APELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSD----PSVENQ---DEVYLPEWIY 343 APE+ S R + G + D++S G+++ ++ G D P++ + Y+PE++ Sbjct: 181 APEVISGRLYAGP--EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 238 Query: 342 EKVISGHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRPS 214 + TL M + + + TI + +W ++ PS Sbjct: 239 RSI-------ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274
>PKNA_MYCLE (P54743) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 437 Score = 53.9 bits (128), Expect = 4e-07 Identities = 36/83 (43%), Positives = 50/83 (60%), Gaps = 1/83 (1%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTA-ARGTMGYIAPELYSRNFG 469 ++H D+KP NIL+ KI+DFG+AK A D + +T T GT YIAPE + Sbjct: 137 LVHRDVKPGNILITPTGQVKITDFGIAK--AVDAAPVTQTGMVMGTAQYIAPEQALGH-- 192 Query: 468 GVSYKSDVYSFGMLVLEMVSGRR 400 + SDVYS G++ E+VSG+R Sbjct: 193 DATPASDVYSLGVIGYEVVSGKR 215
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 53.9 bits (128), Expect = 4e-07 Identities = 42/118 (35%), Positives = 61/118 (51%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 +EY H I++ D+KP NILLD N + KI+DFG AK + +T T GT YI Sbjct: 181 LEYLHA---HNIIYRDLKPENILLDRNGHIKITDFGFAK----EVQTVTWTLC-GTPDYI 232 Query: 498 APELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 APE+ + + D +S G+L+ EM++G P + P YEK++ G Sbjct: 233 APEVITTK--PYNKSVDWWSLGVLIYEMLAG---YTPFYDT-----TPMKTYEKILQG 280
>PKN1_COREF (Q8FUI5) Probable serine/threonine protein kinase CE0033 (EC| 2.7.11.1) Length = 660 Score = 53.9 bits (128), Expect = 4e-07 Identities = 31/82 (37%), Positives = 48/82 (58%), Gaps = 1/82 (1%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAA-RGTMGYIAPELYSRNFG 469 I+H D+KP NI+++ K+ DFG+A+ S +T TAA GT Y++PE Sbjct: 132 IIHRDVKPANIMINNTGGVKVMDFGIARALDDSTSAMTQTAAVIGTAQYLSPE--QARGK 189 Query: 468 GVSYKSDVYSFGMLVLEMVSGR 403 +SDVY+ G ++ E+V+GR Sbjct: 190 PADARSDVYAAGCVLYELVTGR 211
>PKN2_COREF (Q8FUI4) Serine/threonine protein kinases drp72 (EC 2.7.11.1)| Length = 520 Score = 53.9 bits (128), Expect = 4e-07 Identities = 37/83 (44%), Positives = 50/83 (60%), Gaps = 1/83 (1%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTA-ARGTMGYIAPELYSRNFG 469 ++H DIKP N+L+ N KI+DFG+AK A LT T GT Y++PE + Sbjct: 144 LVHRDIKPGNMLITANGILKITDFGIAKAAA--SVPLTRTGMVVGTAQYVSPEQAQGH-- 199 Query: 468 GVSYKSDVYSFGMLVLEMVSGRR 400 V+ SDVYS G++ EM+SGRR Sbjct: 200 QVTPASDVYSLGVVGYEMLSGRR 222
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 53.9 bits (128), Expect = 4e-07 Identities = 36/104 (34%), Positives = 57/104 (54%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y + +H D++ NIL+ N KI+DFGLA+L D A+ + + Sbjct: 380 GMAYIER---MNYIHRDLRAANILVGDNLVCKIADFGLARLI-EDNEYTARQGAKFPIKW 435 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQD 370 APE + +G + KSDV+SFG+L+ E+V+ R P + N++ Sbjct: 436 TAPE--AALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNRE 477
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 53.9 bits (128), Expect = 4e-07 Identities = 36/104 (34%), Positives = 57/104 (54%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y + +H D++ NIL+ N KI+DFGLA+L D A+ + + Sbjct: 376 GMAYIER---MNYIHRDLRAANILVGDNLVCKIADFGLARLI-EDNEYTARQGAKFPIKW 431 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQD 370 APE + +G + KSDV+SFG+L+ E+V+ R P + N++ Sbjct: 432 TAPE--AALYGRFTIKSDVWSFGILLTELVAKGRVPYPGMVNRE 473
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 53.9 bits (128), Expect = 4e-07 Identities = 38/101 (37%), Positives = 56/101 (55%), Gaps = 8/101 (7%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILL-----DYNFNP---KISDFGLAKLCARDQSILTL 529 RGM Y H I+H D+K NIL+ ++N KI+DFGL AR+ T Sbjct: 205 RGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGL----AREWHKTTK 260 Query: 528 TAARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +A GT ++APE+ + S SDV+SFG+L+ E+++G Sbjct: 261 MSAAGTYAWMAPEVIRLSL--FSKSSDVWSFGVLLWELLTG 299
>WIS4_SCHPO (O14299) MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase| kinase kinase wak1) (MAP kinase kinase kinase wik1) Length = 1401 Score = 53.5 bits (127), Expect = 6e-07 Identities = 39/100 (39%), Positives = 52/100 (52%), Gaps = 8/100 (8%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCA-------RDQSIL-TLT 526 G+ Y H +Q ILH DIKP NILLD+ K SDFG A + R + I L Sbjct: 1148 GLAYIH---SQHILHRDIKPANILLDHRGMIKYSDFGSALYVSPPTDPEVRYEDIQPELQ 1204 Query: 525 AARGTMGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 GT Y+APE+ G D++S G ++LEM++G Sbjct: 1205 HLAGTPMYMAPEIILGTKKGDFGAMDIWSLGCVILEMMTG 1244
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 53.5 bits (127), Expect = 6e-07 Identities = 33/91 (36%), Positives = 54/91 (59%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G++Y H + ++H DIK NILL + K++DFG++ + + S LTL GT+ + Sbjct: 133 GLKYLH---GEGVIHRDIKAANILLSADNTVKLADFGVSTIV--NSSALTLA---GTLNW 184 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVS 409 +APE+ G S SD++S G V+EM++ Sbjct: 185 MAPEILGNR--GASTLSDIWSLGATVVEMLT 213
>MYLK_CHICK (P11799) Myosin light chain kinase, smooth muscle and non-muscle| isozymes (EC 2.7.11.18) (MLCK) [Contains: Telokin] Length = 1906 Score = 53.5 bits (127), Expect = 6e-07 Identities = 34/94 (36%), Positives = 56/94 (59%), Gaps = 2/94 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILL--DYNFNPKISDFGLAKLCARDQSILTLTAARGTM 508 G+EY H+ Q I+H D+KP NI+ + K+ DFGLA+ R +S +L GT Sbjct: 1561 GVEYIHK---QGIVHLDLKPENIMCVNKTGTSIKLIDFGLAR---RLESAGSLKVLFGTP 1614 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 ++APE+ N+ + Y++D++S G++ +VSG Sbjct: 1615 EFVAPEVI--NYEPIGYETDMWSIGVICYILVSG 1646
>RK_BOVIN (P28327) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 561 Score = 53.5 bits (127), Expect = 6e-07 Identities = 39/124 (31%), Positives = 65/124 (52%), Gaps = 3/124 (2%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+E+ HQ + I++ D+KP N+LLD + N +ISD GLA Q+ GT G+ Sbjct: 301 GLEHLHQ---RNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQT--KTKGYAGTPGF 355 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR---RNSDPSVENQDEVYLPEWIYEKVI 331 +APEL + D ++ G+ + EM++ R R VEN++ L + + E+ + Sbjct: 356 MAPELLLGE--EYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKE---LKQRVLEQAV 410 Query: 330 SGHD 319 + D Sbjct: 411 TYPD 414
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 53.5 bits (127), Expect = 6e-07 Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 1/174 (0%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GMEY +++++H D+ NIL+ + K+SDFGLAK + L ++R + + Sbjct: 337 GMEYLE---SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKG-----LDSSRLPVKW 388 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGH 322 APE G S KSDV+SFG+L+ E+ S R P + ++ + E V G+ Sbjct: 389 TAPEALKN--GRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKE-------VSEAVEKGY 439 Query: 321 DWELTLEMTAEDKEKMMQLTIVG-LWSIQWNPKNRPSMTKVVNMLTGRLQNLQI 163 M D T++G W + P RP K+V L L+++ + Sbjct: 440 ------RMEPPDGCPGSVHTLMGSCWEAE--PARRPPFRKIVEKLGRELRSVGV 485
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 53.5 bits (127), Expect = 6e-07 Identities = 38/136 (27%), Positives = 69/136 (50%), Gaps = 15/136 (11%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GMEY +++++H D+ N+L+ N KI DFGLA++ A D +R + + Sbjct: 391 GMEYLE---SKQLIHRDLAARNVLIGENNVAKICDFGLARVIA-DDEYCPKQGSRFPVKW 446 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEV-------------- 364 APE +G S KSDV+S+G+L++E+ + + P + +++ + Sbjct: 447 TAPEAII--YGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTN 504 Query: 363 -YLPEWIYEKVISGHD 319 Y P+ IY+ ++ D Sbjct: 505 HYFPDNIYQLLLQCWD 520
>CDC2A_ANTMA (Q38772) Cell division control protein 2 homolog A (EC 2.7.11.22)| (EC 2.7.11.23) Length = 294 Score = 53.5 bits (127), Expect = 6e-07 Identities = 40/97 (41%), Positives = 56/97 (57%), Gaps = 3/97 (3%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNP-KISDFGLAKLCARDQSILTLTAARGTM 508 RG+ Y H + R+LH D+KP N+L+D N K++DFGLA+ A + T T T+ Sbjct: 113 RGIAYCH---SHRVLHRDLKPQNLLIDRRTNALKLADFGLAR--AFGIPVRTFTHEVVTL 167 Query: 507 GYIAPE--LYSRNFGGVSYKSDVYSFGMLVLEMVSGR 403 Y APE L SR++ S DV+S G + EMV+ R Sbjct: 168 WYRAPEILLGSRHY---STPVDVWSVGCIFAEMVNQR 201
>SKM1_YEAST (Q12469) Serine/threonine-protein kinase SKM1 (EC 2.7.11.1)| (Protein kinase 75490 D) Length = 655 Score = 53.5 bits (127), Expect = 6e-07 Identities = 36/103 (34%), Positives = 59/103 (57%), Gaps = 4/103 (3%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGL-AKLCARDQSILTLTAARGTM 508 +G+++ H N++I+H DIK NILL+ KI+DFG +L + T+ GT Sbjct: 493 QGLKFLH---NKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMV---GTP 546 Query: 507 GYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGR---RNSDP 388 ++APE+ ++ G K DV+S G++++EM+ G N DP Sbjct: 547 YWMAPEIVNQK--GYDEKVDVWSLGIMLIEMIEGEPPYLNEDP 587
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 53.5 bits (127), Expect = 6e-07 Identities = 31/80 (38%), Positives = 51/80 (63%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 I++ D+KP NILLD + K++DFGL+K + + GT+ Y+APE+ +R G Sbjct: 189 IIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEK--KAYSFCGTVEYMAPEVVNRR--G 244 Query: 465 VSYKSDVYSFGMLVLEMVSG 406 + +D +SFG+L+ EM++G Sbjct: 245 HTQSADWWSFGVLMFEMLTG 264 Score = 50.1 bits (118), Expect = 6e-06 Identities = 40/122 (32%), Positives = 61/122 (50%), Gaps = 4/122 (3%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNIL-LDYNFNP---KISDFGLAKLCARDQSILTLTAARGT 511 +EY H Q ++H D+KP NIL +D + NP +I DFG AK + +L T Sbjct: 527 VEYLHA---QGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY--T 581 Query: 510 MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVI 331 ++APE+ R G D++S G+L+ M++G P D+ PE I ++ Sbjct: 582 ANFVAPEVLKRQ--GYDAACDIWSLGVLLYTMLTG---YTPFANGPDDT--PEEILARIG 634 Query: 330 SG 325 SG Sbjct: 635 SG 636
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 53.5 bits (127), Expect = 6e-07 Identities = 31/80 (38%), Positives = 51/80 (63%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 I++ D+KP NILLD + K++DFGL+K + + GT+ Y+APE+ +R G Sbjct: 189 IIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEK--KAYSFCGTVEYMAPEVVNRR--G 244 Query: 465 VSYKSDVYSFGMLVLEMVSG 406 + +D +SFG+L+ EM++G Sbjct: 245 HTQSADWWSFGVLMFEMLTG 264 Score = 50.1 bits (118), Expect = 6e-06 Identities = 40/122 (32%), Positives = 61/122 (50%), Gaps = 4/122 (3%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNIL-LDYNFNP---KISDFGLAKLCARDQSILTLTAARGT 511 +EY H Q ++H D+KP NIL +D + NP +I DFG AK + +L T Sbjct: 527 VEYLHA---QGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY--T 581 Query: 510 MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVI 331 ++APE+ R G D++S G+L+ M++G P D+ PE I ++ Sbjct: 582 ANFVAPEVLKRQ--GYDAACDIWSLGVLLYTMLTG---YTPFANGPDDT--PEEILARIG 634 Query: 330 SG 325 SG Sbjct: 635 SG 636
>KIN11_ARATH (P92958) SNF1-related protein kinase catalytic alpha subunit KIN11| (EC 2.7.11.1) (AKIN11) (AKIN alpha1) Length = 512 Score = 53.5 bits (127), Expect = 6e-07 Identities = 44/143 (30%), Positives = 76/143 (53%), Gaps = 1/143 (0%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 G+EY H+ ++H D+KP N+LLD N KI+DFGL+ + RD L + G+ Y Sbjct: 130 GVEYCHRNM---VVHRDLKPENLLLDSRCNIKIADFGLSNV-MRDGHFLKTSC--GSPNY 183 Query: 501 IAPELYS-RNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISG 325 APE+ S + + G + DV+S G+++ ++ G D EN ++ K I G Sbjct: 184 AAPEVISGKLYAGP--EVDVWSCGVILYALLCGTLPFDD--ENIPNLF-------KKIKG 232 Query: 324 HDWELTLEMTAEDKEKMMQLTIV 256 + L +++E ++ + ++ IV Sbjct: 233 GIYTLPSHLSSEARDLIPRMLIV 255
>IPL1_CANGA (Q6FV07) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 358 Score = 53.5 bits (127), Expect = 6e-07 Identities = 44/159 (27%), Positives = 78/159 (49%), Gaps = 5/159 (3%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYI 499 + Y H+ +RI+H D+KP N+L+ ++ K++DFG + L TL GT+ Y+ Sbjct: 211 LHYMHK---KRIIHRDVKPENVLIGFDNVVKLADFGWSILNPEGSKRKTLC---GTIDYL 264 Query: 498 APELYSRNFGGVSYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWI-----YEKV 334 +PE+ + + DV++ G+L E+V G P EN E+ + + + Sbjct: 265 SPEMITPR--EYDEQVDVWALGVLAYELVVG---VPPFEENSKELTYKRILKCDLNFPES 319 Query: 333 ISGHDWELTLEMTAEDKEKMMQLTIVGLWSIQWNPKNRP 217 IS +L ++ D + + LT G+ + W KN+P Sbjct: 320 ISKDAKDLISKLLVTDTTQRLSLT--GVKTHPWILKNKP 356
>CDKL3_MOUSE (Q8BLF2) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| Length = 595 Score = 53.5 bits (127), Expect = 6e-07 Identities = 35/95 (36%), Positives = 51/95 (53%), Gaps = 2/95 (2%) Frame = -2 Query: 684 RGMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMG 505 R +EY H N I+H DIKP NIL+ + K+ DFG A+ A + T A T Sbjct: 111 RAIEYLH---NNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVA--TRW 165 Query: 504 YIAPELYSRNFGGVSYKS--DVYSFGMLVLEMVSG 406 Y APEL ++ SY D+++ G +++EM +G Sbjct: 166 YRAPELVLKD---TSYGKPVDIWALGCMIIEMATG 197
>LRRK2_MOUSE (Q5S006) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 2527 Score = 53.5 bits (127), Expect = 6e-07 Identities = 35/94 (37%), Positives = 54/94 (57%), Gaps = 8/94 (8%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNP------KISDFGLAKLCARDQSILTLTAA 520 G+ Y H I++ D+KPHN+LL + P KI+D+G+A+ C R + + + Sbjct: 1981 GLRYLHSAM---IIYRDLKPHNVLL-FTLYPNAAIIAKIADYGIAQYCCR----MGIKTS 2032 Query: 519 RGTMGYIAPELYSRNFGGVSY--KSDVYSFGMLV 424 GT G+ APE+ G V Y ++DVYSFG+L+ Sbjct: 2033 EGTPGFRAPEVAR---GNVIYNQQADVYSFGLLL 2063
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 53.5 bits (127), Expect = 6e-07 Identities = 34/92 (36%), Positives = 56/92 (60%) Frame = -2 Query: 681 GMEYXHQGCNQRILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGY 502 GM Y H +I+H D+K N+L+ + KISDFG +K + D+S T + GT+ + Sbjct: 266 GMNYLHL---HKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS-DKS--TKMSFAGTVAW 319 Query: 501 IAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 +APE+ VS K D++SFG+++ E+++G Sbjct: 320 LAPEVIRNE--PVSEKVDIWSFGVVLWELLTG 349
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 53.5 bits (127), Expect = 6e-07 Identities = 30/81 (37%), Positives = 49/81 (60%), Gaps = 1/81 (1%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLT-AARGTMGYIAPELYSRNFG 469 I+H D+KP NIL+ K++DFG+AK + D S + T + G+ Y +PE + Sbjct: 129 IIHRDVKPQNILVTEEGVVKVTDFGIAK--SMDSSTIAHTNSVMGSAHYFSPEQAKGTY- 185 Query: 468 GVSYKSDVYSFGMLVLEMVSG 406 Y++D+YS G+++ EMV+G Sbjct: 186 -TDYRTDLYSLGIVLYEMVTG 205
>ERK1_CANAL (P28869) Extracellular signal-regulated kinase 1 (EC 2.7.11.24)| (ERK1) (MAP kinase 1) (MAPK 1) Length = 417 Score = 53.5 bits (127), Expect = 6e-07 Identities = 32/82 (39%), Positives = 50/82 (60%), Gaps = 1/82 (1%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAK-LCARDQSILTLTAARGTMGYIAPELYSRNFG 469 +LH D+KP N+LL+ N + KI DFGLA+ + +++ + +T T Y APE+ F Sbjct: 188 VLHRDLKPSNLLLNSNCDLKICDFGLARSIASQEDNYGFMTEYVATRWYRAPEI-MLTFQ 246 Query: 468 GVSYKSDVYSFGMLVLEMVSGR 403 + DV+S G ++ EM+SGR Sbjct: 247 EYTTAIDVWSVGCILAEMLSGR 268
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1)| (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 53.1 bits (126), Expect = 8e-07 Identities = 33/80 (41%), Positives = 52/80 (65%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 I++ D+KP NILLD + K++DFGL+K DQ + GT+ Y+APE+ +R G Sbjct: 194 IVYRDLKPENILLDEIGHIKLTDFGLSKESV-DQEKKAYSFC-GTVEYMAPEVVNRR--G 249 Query: 465 VSYKSDVYSFGMLVLEMVSG 406 S +D +S+G+L+ EM++G Sbjct: 250 HSQSADWWSYGVLMFEMLTG 269 Score = 40.0 bits (92), Expect = 0.007 Identities = 33/95 (34%), Positives = 53/95 (55%), Gaps = 4/95 (4%) Frame = -2 Query: 678 MEYXHQGCNQRILHFDIKPHNIL-LDYNFNP---KISDFGLAKLCARDQSILTLTAARGT 511 ++Y H C Q ++H D+KP NIL +D + + +I DFG AK R ++ L LT T Sbjct: 531 VDYLH--C-QGVVHRDLKPSNILYMDESASADSIRICDFGFAKQ-LRGENGLLLTPCY-T 585 Query: 510 MGYIAPELYSRNFGGVSYKSDVYSFGMLVLEMVSG 406 ++APE+ + G D++S G+L M++G Sbjct: 586 ANFVAPEVLMQQ--GYDAACDIWSLGVLFYTMLAG 618
>GRK7_PIG (Q8WP15) G protein-coupled receptor kinase 7 precursor (EC| 2.7.11.16) (G protein-coupled receptor kinase GRK7) Length = 553 Score = 53.1 bits (126), Expect = 8e-07 Identities = 32/81 (39%), Positives = 46/81 (56%) Frame = -2 Query: 645 ILHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGG 466 I++ D+KP N+LLD N ++SD GLA + Q +T GT GY+APE+ Sbjct: 312 IVYRDLKPENVLLDDLGNCRLSDLGLA---VQIQDGKPVTQRAGTNGYMAPEILMEK-AS 367 Query: 465 VSYKSDVYSFGMLVLEMVSGR 403 SY D ++ G + EMV+GR Sbjct: 368 YSYPVDWFAMGCSIYEMVAGR 388
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 53.1 bits (126), Expect = 8e-07 Identities = 45/151 (29%), Positives = 73/151 (48%) Frame = -2 Query: 642 LHFDIKPHNILLDYNFNPKISDFGLAKLCARDQSILTLTAARGTMGYIAPELYSRNFGGV 463 +H D++ NIL+ KI+DFGLA+L D A+ + + APE + FG Sbjct: 402 IHRDLRAANILVGERLVCKIADFGLARLI-EDNEYNPRQGAKFPIKWTAPE--AALFGRF 458 Query: 462 SYKSDVYSFGMLVLEMVSGRRNSDPSVENQDEVYLPEWIYEKVISGHDWELTLEMTAEDK 283 + KSDV+SFG+L+ E++S R P + N++ + E+V G+ A Sbjct: 459 TIKSDVWSFGILLTELISKGRVPYPGMNNRE-------VLEQVEHGYHMPCPPGCPASLY 511 Query: 282 EKMMQLTIVGLWSIQWNPKNRPSMTKVVNML 190 E M Q W + +P+ RP+ + + L Sbjct: 512 EAMEQ-----TWRL--DPEERPTFEYLQSFL 535 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 111,230,882 Number of Sequences: 219361 Number of extensions: 2641130 Number of successful extensions: 9954 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 8804 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 9297 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6769072002 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
