ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | rbasd1j22 |
|---|---|
| Clone Library Name | barley_pub |
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 121 bits (304), Expect = 2e-27 Identities = 61/139 (43%), Positives = 86/139 (61%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGSSN 414 I+H DLKS N+L+ D + K+ D G SK GT+ WMAPE++ Sbjct: 232 IIHRDLKSPNMLITYDD----VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP- 286 Query: 413 LVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSLMEQ 234 VSEKVD++SFG+V+WELLTGE PY D+ AII G+ +N+L VP SC ++ L+ Q Sbjct: 287 -VSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQ 345 Query: 233 CWSAEPTERPSFTEVVKRL 177 CW+++P RPSF +++ L Sbjct: 346 CWNSKPRNRPSFRQILLHL 364
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 121 bits (304), Expect = 2e-27 Identities = 61/139 (43%), Positives = 86/139 (61%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGSSN 414 I+H DLKS N+L+ D + K+ D G SK GT+ WMAPE++ Sbjct: 265 IIHRDLKSPNMLITYDD----VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP- 319 Query: 413 LVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSLMEQ 234 VSEKVD++SFG+V+WELLTGE PY D+ AII G+ +N+L VP SC ++ L+ Q Sbjct: 320 -VSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQ 378 Query: 233 CWSAEPTERPSFTEVVKRL 177 CW+++P RPSF +++ L Sbjct: 379 CWNSKPRNRPSFRQILLHL 397
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 120 bits (302), Expect = 3e-27 Identities = 61/139 (43%), Positives = 85/139 (61%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGSSN 414 I+H DLKS N+L+ D + K+ D G SK GT+ WMAPE++ Sbjct: 265 IIHRDLKSPNMLITYDD----VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP- 319 Query: 413 LVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSLMEQ 234 VSEKVD++SFG+V+WELLTGE PY D+ AII G+ +N+L VP SC ++ L+ Q Sbjct: 320 -VSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQ 378 Query: 233 CWSAEPTERPSFTEVVKRL 177 CW+ +P RPSF +++ L Sbjct: 379 CWNRKPRNRPSFRQILLHL 397
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 115 bits (287), Expect = 1e-25 Identities = 61/139 (43%), Positives = 83/139 (59%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGSSN 414 I+H DLKS N+LV D K+ D G SK GT+ WMAPE++ Sbjct: 275 IIHRDLKSPNVLVTHTDA----VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP- 329 Query: 413 LVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSLMEQ 234 VSEKVD++SFG+V+WELLTGE PY D+ AII G+ +N+L VP +C ++ LM+Q Sbjct: 330 -VSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQ 388 Query: 233 CWSAEPTERPSFTEVVKRL 177 W ++P RPSF + + L Sbjct: 389 TWQSKPRNRPSFRQTLMHL 407
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 114 bits (284), Expect = 3e-25 Identities = 60/139 (43%), Positives = 83/139 (59%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGSSN 414 I+H DLKS N+LV D K+ D G SK GT+ W+APE++ Sbjct: 275 IIHRDLKSPNVLVTHTDA----VKISDFGTSKELSDKSTKMSFAGTVAWLAPEVIRNEP- 329 Query: 413 LVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSLMEQ 234 VSEKVD++SFG+V+WELLTGE PY D+ AII G+ +N+L VP +C ++ LM+Q Sbjct: 330 -VSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQ 388 Query: 233 CWSAEPTERPSFTEVVKRL 177 W ++P RPSF + + L Sbjct: 389 TWQSKPRNRPSFRQTLMHL 407
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 109 bits (272), Expect = 8e-24 Identities = 61/170 (35%), Positives = 97/170 (57%), Gaps = 9/170 (5%) Frame = -1 Query: 629 LHLVWNICTGKN--------IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLIS 474 L + +++ G N IVH DLKS NLLV+ ++ KV D GLS++K T +S Sbjct: 652 LSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVD----KKYTVKVCDFGLSRLKASTFLS 707 Query: 473 G-GVRGTLPWMAPELLNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVN 297 GT WMAPE+L + +EK DV+SFG+++WEL T ++P+ +L+ ++ + Sbjct: 708 SKSAAGTPEWMAPEVLRDEPS--NEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGF 765 Query: 296 NTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKP 147 R +P + +PQ +++E CW+ EP +RPSF ++ LR + S P Sbjct: 766 KCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAVPP 815
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 105 bits (261), Expect = 1e-22 Identities = 58/147 (39%), Positives = 86/147 (58%), Gaps = 4/147 (2%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLN 426 IVH DL S N+L++ + K+ D GLS K + T+ +GG+ W PEL Sbjct: 228 IVHRDLTSQNILLD----ELGNIKISDFGLSAEKSREGSMTMTNGGICNPR-WRPPELTK 282 Query: 425 GSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + SEKVDV+ F +V+WE+LTGE P++DL + LRP +PE CDP+ + Sbjct: 283 NLGHY-SEKVDVYCFSLVVWEILTGEIPFSDLDGSQRSAQVAYAGLRPPIPEYCDPELKL 341 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMA 165 L+ QCW A+P +RP FT +V +L+ ++ Sbjct: 342 LLTQCWEADPNDRPPFTYIVNKLKEIS 368
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 103 bits (257), Expect = 4e-22 Identities = 54/150 (36%), Positives = 88/150 (58%), Gaps = 4/150 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLV----NLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELL 429 +I+H DLKS N+L+ Q+ K+ D GL++ T GT WM PE++ Sbjct: 259 SIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAA-GTYAWMPPEVI 317 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + S+ S+ DV+S+G+++WEL+TGE PY ++ G+ NTL +P++C W Sbjct: 318 SVST--YSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWG 375 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATS 159 +LM+ CW +P +RP F E++K+L ++A S Sbjct: 376 ALMKSCWQTDPHKRPGFKEILKQLESIACS 405
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 102 bits (255), Expect = 7e-22 Identities = 60/173 (34%), Positives = 98/173 (56%), Gaps = 19/173 (10%) Frame = -1 Query: 629 LHLVWNICTGKN--------IVHFDLKSDNLLVNLR-DPQRPI--------CKVGDLGLS 501 L L +I G N I+H DL S N+L++ DP+ P+ CK+ D GLS Sbjct: 1393 LKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLS 1452 Query: 500 KVKCQ--TLISGGVRGTLPWMAPELLNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLH 327 ++K + + ++ V G +P+MAPE+ G SN SEK DV+S+G+V++ELLT +EP D+ Sbjct: 1453 RLKKEQASQMTQSV-GCIPYMAPEVFKGDSN--SEKSDVYSYGMVLFELLTSDEPQQDMK 1509 Query: 326 YGAIIGGIVNNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAM 168 + + RP +P + +W+ ++ QCW + P RP+F +++ L+ M Sbjct: 1510 PMKMAHLAAYESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIVHLKEM 1562
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 102 bits (253), Expect = 1e-21 Identities = 58/152 (38%), Positives = 86/152 (56%), Gaps = 7/152 (4%) Frame = -1 Query: 593 IVHFDLKSDNLLV-------NLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPE 435 I+H DLKS N+L+ NL D + K+ D GL++ +T GT WMAPE Sbjct: 218 IIHRDLKSINILILEAIENHNLADT---VLKITDFGLAREWHKTTKMSAA-GTYAWMAPE 273 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQ 255 ++ S L S+ DV+SFG+++WELLTGE PY ++ A+ G+ N L +P +C Sbjct: 274 VIRLS--LFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEP 331 Query: 254 WRSLMEQCWSAEPTERPSFTEVVKRLRAMATS 159 + L+E+CW +P RP F ++KRL + S Sbjct: 332 FARLLEECWDPDPHGRPDFGSILKRLEVIEQS 363
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 102 bits (253), Expect = 1e-21 Identities = 55/149 (36%), Positives = 85/149 (57%), Gaps = 4/149 (2%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLR----DPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLN 426 I+H DLKS N+L+ + D I K+ D GL++ +T GT WMAPE++ Sbjct: 264 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAA-GTYAWMAPEVIR 322 Query: 425 GSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 S + S+ DV+S+G+++WELLTGE P+ + A+ G+ N L +P +C + Sbjct: 323 AS--MFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAK 380 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATS 159 LME CW+ +P RPSFT ++ +L + S Sbjct: 381 LMEDCWNPDPHSRPSFTNILDQLTTIEES 409
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 98.6 bits (244), Expect(2) = 6e-21 Identities = 54/138 (39%), Positives = 78/138 (56%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGS 420 + ++H DLKS+NLL+N D R KV D G S ++ Q + G GT WMAPE++ Sbjct: 206 QGVIHRDLKSNNLLLN--DEMR--VKVADFGTSCLETQCREAKGNMGTYRWMAPEMIKEK 261 Query: 419 SNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSLM 240 + KVDV+SFGIV+WEL T P+ + + RP +P SC P L+ Sbjct: 262 P--YTRKVDVYSFGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLI 319 Query: 239 EQCWSAEPTERPSFTEVV 186 ++CWS P++RP F+ +V Sbjct: 320 KRCWSENPSKRPDFSNIV 337 Score = 21.9 bits (45), Expect(2) = 6e-21 Identities = 7/13 (53%), Positives = 11/13 (84%) Frame = -3 Query: 636 MDVAFGMEYLHGK 598 +D++ GMEYLH + Sbjct: 194 LDISRGMEYLHSQ 206
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 99.8 bits (247), Expect = 6e-21 Identities = 52/146 (35%), Positives = 83/146 (56%), Gaps = 4/146 (2%) Frame = -1 Query: 593 IVHFDLKSDNLL----VNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLN 426 ++H DLKS+N+L + D + K+ D GL++ +T GT WMAPE++ Sbjct: 237 VIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAA-GTYAWMAPEVIK 295 Query: 425 GSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 S+ S+ DV+SFG+++WELLTGE PY + A+ G+ N L +P +C + Sbjct: 296 AST--FSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQ 353 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAM 168 LM CW+ +P RP F ++++L A+ Sbjct: 354 LMADCWAQDPHRRPDFASILQQLEAL 379
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 98.6 bits (244), Expect = 1e-20 Identities = 54/146 (36%), Positives = 86/146 (58%), Gaps = 4/146 (2%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPIC----KVGDLGLSKVKCQTLISGGVRGTLPWMAPELLN 426 I+H DLKS N+L+ + IC K+ D GL++ +T GT WMAPE++ Sbjct: 259 ILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTT-KMSTAGTYAWMAPEVIK 317 Query: 425 GSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 S+L S+ D++S+G+++WELLTGE PY + A+ G+ N L +P +C + Sbjct: 318 --SSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAK 375 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAM 168 LM++CW +P RPSF ++++L A+ Sbjct: 376 LMKECWQQDPHIRPSFALILEQLTAI 401
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 98.2 bits (243), Expect = 2e-20 Identities = 53/139 (38%), Positives = 84/139 (60%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGSSN 414 IVH D+K N+LV+ + K+ D G +++K GT W APE++ G Sbjct: 1483 IVHRDIKPANILVD----EHFNVKIADFGFARIKEDNTTMTRC-GTPCWTAPEVIRGEK- 1536 Query: 413 LVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSLMEQ 234 EK DVFSFG+VMWE+LTG+EP+A+ ++ + I+ RP++P C ++ L+++ Sbjct: 1537 -YCEKADVFSFGVVMWEVLTGKEPFAECNFMKVSLDILEGG-RPIIPSDCPHEFAKLIKK 1594 Query: 233 CWSAEPTERPSFTEVVKRL 177 CW A+ +RP+ TEVV++L Sbjct: 1595 CWHAKAHKRPTMTEVVQQL 1613 Score = 98.2 bits (243), Expect = 2e-20 Identities = 55/146 (37%), Positives = 87/146 (59%), Gaps = 7/146 (4%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT---LISGGVRGTLPWMAPELLNG 423 IVH DLKS NLL++ + KV D GL+KVK + + + GT+ W+APE+LN Sbjct: 904 IVHRDLKSLNLLLD----SKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIAPEILND 959 Query: 422 SSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESC----DPQ 255 S+ + DV+SFGI++WELLT E+PY + AI ++ + +RP + + + Sbjct: 960 STEVDYILADVYSFGIILWELLTREQPYKGMTPAAIAVSVIRDGMRPPISDEAVTAHSIE 1019 Query: 254 WRSLMEQCWSAEPTERPSFTEVVKRL 177 + L++QCW ++ RP+F E++ RL Sbjct: 1020 YIDLIKQCWHSDTIIRPTFLEIMTRL 1045
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 95.5 bits (236), Expect = 1e-19 Identities = 52/149 (34%), Positives = 81/149 (54%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGSSN 414 ++H DLKS N+++ + K+ D G S+ T V GT PWMAPE++ S Sbjct: 129 VIHRDLKSRNVVIAADG----VLKICDFGASRFHNHTTHMSLV-GTFPWMAPEVIQ--SL 181 Query: 413 LVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSLMEQ 234 VSE D +S+G+V+WE+LT E P+ L + +V R +P SC + L+ Q Sbjct: 182 PVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQ 241 Query: 233 CWSAEPTERPSFTEVVKRLRAMATSPTKP 147 CW A+ +RPSF +++ L +M+ + P Sbjct: 242 CWEADAKKRPSFKQIISILESMSNDTSLP 270
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 95.1 bits (235), Expect = 2e-19 Identities = 52/149 (34%), Positives = 80/149 (53%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGSSN 414 ++H DLKS N+++ + K+ D G S+ T V GT PWMAPE++ S Sbjct: 129 VIHRDLKSRNVVIAADG----VLKICDFGASRFHNHTTHMSLV-GTFPWMAPEVIQ--SL 181 Query: 413 LVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSLMEQ 234 VSE D +S+G+V+WE+LT E P+ L + +V R +P SC + L+ Q Sbjct: 182 PVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQ 241 Query: 233 CWSAEPTERPSFTEVVKRLRAMATSPTKP 147 CW A+ +RPSF +++ L +M+ P Sbjct: 242 CWEADAKKRPSFKQIISILESMSNDTNLP 270
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 88.6 bits (218), Expect = 1e-17 Identities = 53/140 (37%), Positives = 81/140 (57%), Gaps = 1/140 (0%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGS 420 K ++H DLK NLL+ IC G + QT ++ +G+ WMAPE+ GS Sbjct: 150 KALIHRDLKPPNLLLVAGGTVLKICDFG----TACDIQTHMTNN-KGSAAWMAPEVFEGS 204 Query: 419 SNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAI-IGGIVNNTLRPLVPESCDPQWRSL 243 + SEK DVFS+GI++WE++T +P+ ++ A I V+N RP + ++ SL Sbjct: 205 N--YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESL 262 Query: 242 MEQCWSAEPTERPSFTEVVK 183 M +CWS +P++RPS E+VK Sbjct: 263 MTRCWSKDPSQRPSMEEIVK 282
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 88.6 bits (218), Expect = 1e-17 Identities = 53/140 (37%), Positives = 81/140 (57%), Gaps = 1/140 (0%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGS 420 K ++H DLK NLL+ IC G + QT ++ +G+ WMAPE+ GS Sbjct: 150 KALIHRDLKPPNLLLVAGGTVLKICDFG----TACDIQTHMTNN-KGSAAWMAPEVFEGS 204 Query: 419 SNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAI-IGGIVNNTLRPLVPESCDPQWRSL 243 + SEK DVFS+GI++WE++T +P+ ++ A I V+N RP + ++ SL Sbjct: 205 N--YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESL 262 Query: 242 MEQCWSAEPTERPSFTEVVK 183 M +CWS +P++RPS E+VK Sbjct: 263 MTRCWSKDPSQRPSMEEIVK 282
>FAK1_HUMAN (Q05397) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| (Protein-tyrosine kinase 2) Length = 1052 Score = 87.0 bits (214), Expect = 4e-17 Identities = 53/144 (36%), Positives = 78/144 (54%), Gaps = 3/144 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELLN 426 K VH D+ + N+LV+ D K+GD GLS+ + +G LP WMAPE +N Sbjct: 540 KRFVHRDIAARNVLVSSND----CVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESIN 595 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + DV+ FG+ MWE+L G +P+ + +IG I N P+ P +C P Sbjct: 596 --FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPM-PPNCPPTLY 652 Query: 248 SLMEQCWSAEPTERPSFTEVVKRL 177 SLM +CW+ +P+ RP FTE+ +L Sbjct: 653 SLMTKCWAYDPSRRPRFTELKAQL 676
>FAK1_RAT (O35346) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1055 Score = 87.0 bits (214), Expect = 4e-17 Identities = 53/144 (36%), Positives = 78/144 (54%), Gaps = 3/144 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELLN 426 K VH D+ + N+LV+ D K+GD GLS+ + +G LP WMAPE +N Sbjct: 540 KRFVHRDIAARNVLVSSND----CVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESIN 595 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + DV+ FG+ MWE+L G +P+ + +IG I N P+ P +C P Sbjct: 596 --FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPM-PPNCPPTLY 652 Query: 248 SLMEQCWSAEPTERPSFTEVVKRL 177 SLM +CW+ +P+ RP FTE+ +L Sbjct: 653 SLMTKCWAYDPSRRPRFTELKAQL 676
>FAK1_MOUSE (P34152) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1090 Score = 87.0 bits (214), Expect = 4e-17 Identities = 53/144 (36%), Positives = 78/144 (54%), Gaps = 3/144 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELLN 426 K VH D+ + N+LV+ D K+GD GLS+ + +G LP WMAPE +N Sbjct: 578 KRFVHRDIAARNVLVSSND----CVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESIN 633 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + DV+ FG+ MWE+L G +P+ + +IG I N P+ P +C P Sbjct: 634 --FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPM-PPNCPPTLY 690 Query: 248 SLMEQCWSAEPTERPSFTEVVKRL 177 SLM +CW+ +P+ RP FTE+ +L Sbjct: 691 SLMTKCWAYDPSRRPRFTELKAQL 714
>FAK1_CHICK (Q00944) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1053 Score = 87.0 bits (214), Expect = 4e-17 Identities = 53/144 (36%), Positives = 78/144 (54%), Gaps = 3/144 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELLN 426 K VH D+ + N+LV+ D K+GD GLS+ + +G LP WMAPE +N Sbjct: 540 KRFVHRDIAARNVLVSATD----CVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESIN 595 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + DV+ FG+ MWE+L G +P+ + +IG I N P+ P +C P Sbjct: 596 --FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPM-PPNCPPTLY 652 Query: 248 SLMEQCWSAEPTERPSFTEVVKRL 177 SLM +CW+ +P+ RP FTE+ +L Sbjct: 653 SLMTKCWAYDPSRRPRFTELKAQL 676
>FAK1_XENLA (Q91738) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1068 Score = 86.7 bits (213), Expect = 5e-17 Identities = 53/144 (36%), Positives = 78/144 (54%), Gaps = 3/144 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELLN 426 K VH D+ + N+LV+ D K+GD GLS+ + +G LP WMAPE +N Sbjct: 553 KRFVHRDIAARNVLVSSSD----CVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESIN 608 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + DV+ FG+ MWE+L G +P+ + +IG I N P+ P +C P Sbjct: 609 --FRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNDVIGRIENGERLPM-PPNCPPTLY 665 Query: 248 SLMEQCWSAEPTERPSFTEVVKRL 177 SLM +CW+ +P+ RP FTE+ +L Sbjct: 666 SLMTKCWAYDPSRRPRFTELKAQL 689
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 86.3 bits (212), Expect = 7e-17 Identities = 57/152 (37%), Positives = 77/152 (50%), Gaps = 5/152 (3%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELL 429 N VH DL + N+LVN +CKV D GLS+V T + G + + W APE + Sbjct: 734 NYVHRDLAARNILVN----SNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAI 789 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 S + DV+SFGIVMWE++T GE PY +L ++ I N+ R P C Sbjct: 790 --SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAI-NDGFRLPTPMDCPSAI 846 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM QCW E RP F ++V L + +P Sbjct: 847 YQLMMQCWQQERARRPKFADIVSILDKLIRAP 878
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 85.5 bits (210), Expect = 1e-16 Identities = 56/152 (36%), Positives = 78/152 (51%), Gaps = 5/152 (3%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELL 429 N VH DL + N+LVN +CKV D GLS+V T + G + + W APE + Sbjct: 735 NYVHRDLAARNILVN----SNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAI 790 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 S + DV+S+GIVMWE++T GE PY +L ++ I N+ R P C Sbjct: 791 --SYRKFTSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAI-NDGFRLPTPMDCPSAI 847 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM QCW E + RP F ++V L + +P Sbjct: 848 YQLMMQCWQQERSRRPKFADIVSILDKLIRAP 879
>PHY1_CERPU (P25848) Light-sensor Protein kinase [Includes: Phytochrome; Protein| kinase (EC 2.7.11.1)] Length = 1307 Score = 84.7 bits (208), Expect = 2e-16 Identities = 58/163 (35%), Positives = 89/163 (54%), Gaps = 21/163 (12%) Frame = -1 Query: 599 KNIVHFDLKSDNLLV-NLRDPQRPI----CKVGDLGLSKVK-CQTLISGGV--RGTLPWM 444 K I+H DLKS N+LV +++ + I KV D GLSK K T S RGT WM Sbjct: 1121 KGIIHRDLKSMNILVKSVKVTKSEIGYVHVKVADFGLSKTKDSSTRYSNQTWNRGTNRWM 1180 Query: 443 APELLN-GSSNLVSE------------KVDVFSFGIVMWELLTGEEPYADLHYGAIIGGI 303 APE++N G + E K DV+SFG+V +E+LTG+ P+ + + + Sbjct: 1181 APEVINLGYESTEGEISFDGKVPKYPLKSDVYSFGMVCYEVLTGDVPFPEEKNPNNVKRM 1240 Query: 302 VNNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLR 174 V +RP +P C + ++L+ CW+ +P +RPSF + ++L+ Sbjct: 1241 VLEGVRPDLPAHCPIELKALITDCWNQDPLKRPSFAVICQKLK 1283
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 82.4 bits (202), Expect = 1e-15 Identities = 52/157 (33%), Positives = 81/157 (51%), Gaps = 4/157 (2%) Frame = -1 Query: 614 NICTGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ---TLISGGVRGTLPWM 444 N +G N VH DL + N+LVN Q CKV D GL+++ T + G + + W Sbjct: 739 NCLSGHNYVHRDLAARNILVN----QNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWT 794 Query: 443 APELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPES 267 APE + + + + DV+SFGIVMWE+L+ G++PY ++ ++ I + P P Sbjct: 795 APEAI--AHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLP-PPVD 851 Query: 266 CDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 C LM+ CW+ + RP F ++ L + T P Sbjct: 852 CPAPLYELMKNCWAYDRARRPHFLQLQAHLEQLLTDP 888
>INSR_AEDAE (Q93105) Insulin-like receptor precursor (EC 2.7.10.1) (MIR)| [Contains: Insulin-like receptor alpha chain; Insulin-like receptor beta chain] Length = 1390 Score = 81.6 bits (200), Expect = 2e-15 Identities = 49/149 (32%), Positives = 77/149 (51%), Gaps = 4/149 (2%) Frame = -1 Query: 611 ICTGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMA 441 + + K VH DL + N +V K+GD G+++ +T G +G LP WMA Sbjct: 1152 VLSAKKFVHRDLAARNCMV----ADDMTVKIGDFGMTRDIYETDYYRKGTKGFLPVRWMA 1207 Query: 440 PELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESC 264 PE L + S DVFS+G+V+WE+ T +PY L ++ +++ + PE+C Sbjct: 1208 PESLK--DGIFSSSSDVFSYGVVLWEMATLASQPYQGLTNDQVLRYVIDGGVMER-PENC 1264 Query: 263 DPQWRSLMEQCWSAEPTERPSFTEVVKRL 177 +LM +CW PT RP+F E++ L Sbjct: 1265 PDNLYNLMRRCWQHRPTARPTFMEIISEL 1293
>EPHA6_RAT (P54758) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 81.6 bits (200), Expect = 2e-15 Identities = 54/152 (35%), Positives = 77/152 (50%), Gaps = 6/152 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV-----KCQTLISGGVRGTLPWMAPELLN 426 VH DL + N+LVN +CKV D GLS+V + +GG + + W APE + Sbjct: 794 VHRDLAARNILVN----SNLVCKVSDFGLSRVLEDDPEAAYTTTGG-KIPIRWTAPEAI- 847 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + S DV+S+GIVMWE+++ GE PY ++ +I I P P C P Sbjct: 848 -AYRKFSSASDVWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLP-APMGCPPSLH 905 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 LM CW E RP FT++V L + +P+ Sbjct: 906 QLMLHCWQKERNHRPKFTDIVSFLDKLIRNPS 937
>EPHA6_MOUSE (Q62413) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 80.5 bits (197), Expect = 4e-15 Identities = 53/152 (34%), Positives = 77/152 (50%), Gaps = 6/152 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV-----KCQTLISGGVRGTLPWMAPELLN 426 VH DL + N+LVN +CKV D GLS+V + +GG + + W APE + Sbjct: 794 VHRDLAARNILVN----SNLVCKVSDFGLSRVLEDDPEAAYTTTGG-KIPIRWTAPEAI- 847 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + S D +S+GIVMWE+++ GE PY ++ +I I P P C P + Sbjct: 848 -AYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLP-APMGCPPSLQ 905 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 LM CW E RP FT++V L + +P+ Sbjct: 906 QLMLHCWQKERNHRPKFTDIVSFLDKLIRNPS 937
>CAD96_DROME (Q9VBW3) Tyrosine kinase receptor Cad96Ca precursor (EC 2.7.10.1)| (Cadherin 96Ca) (Tyrosine kinase receptor HD-14) Length = 773 Score = 80.5 bits (197), Expect = 4e-15 Identities = 52/147 (35%), Positives = 77/147 (52%), Gaps = 4/147 (2%) Frame = -1 Query: 605 TGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRGTLP--WMAPE 435 T + I+H DL + N+L+ CKV D G ++ V + G LP WMA E Sbjct: 602 TSRGIIHRDLAARNILIT----DDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATE 657 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 L N+ S K D++SFGI+MWE++T G PY + ++ V + R PE C Sbjct: 658 SLY--DNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRK-VRDGYRLEKPEHCRR 714 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRL 177 + ++M CWS +P ERP F E+++ L Sbjct: 715 ELYNIMYYCWSHDPQERPLFAEIIQML 741
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 80.1 bits (196), Expect = 5e-15 Identities = 48/145 (33%), Positives = 83/145 (57%), Gaps = 7/145 (4%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGG---VRGTLPWMAPELL 429 K I+H D+K+DNLL++ Q ICK+ D G+S+ K + + S +RGT+ WMAPE++ Sbjct: 1297 KGILHRDMKADNLLLD----QDGICKISDFGISR-KSKDIYSNSDMTMRGTVFWMAPEMV 1351 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQ-- 255 + S KVD++S G ++ E+ G+ P+++L A + I + P +PE P Sbjct: 1352 DTKQG-YSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLIS 1410 Query: 254 --WRSLMEQCWSAEPTERPSFTEVV 186 R+ ++ C+ P +RP+ E++ Sbjct: 1411 QIGRNFLDACFEINPEKRPTANELL 1435
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 80.1 bits (196), Expect = 5e-15 Identities = 56/160 (35%), Positives = 83/160 (51%), Gaps = 18/160 (11%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKC-----------QTLISGGVR--- 462 K ++H DLK +N+LV+ RD K+ DLG++ K Q +S + Sbjct: 132 KGVIHKDLKPENILVD-RDFH---IKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNN 187 Query: 461 -GTLPWMAPELLNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLR 285 GTL +MAPE LN + +EK DV+SFGIV+W + +EPY ++ + + R Sbjct: 188 GGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNR 247 Query: 284 PLVP---ESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLR 174 P V E C + SLME+CW A P +RP+F + + R Sbjct: 248 PNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFR 287
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 80.1 bits (196), Expect = 5e-15 Identities = 53/154 (34%), Positives = 74/154 (48%), Gaps = 7/154 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + G +P W APE Sbjct: 739 NYVHRDLAARNILVN----SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPE 794 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + + DV+S+GIVMWE+++ GE PY D+ +I I + P P C Sbjct: 795 AI--AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLP-PPMDCPA 851 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP F E+V L M +P Sbjct: 852 ALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNP 885
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 80.1 bits (196), Expect = 5e-15 Identities = 53/154 (34%), Positives = 74/154 (48%), Gaps = 7/154 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + G +P W APE Sbjct: 739 NYVHRDLAARNILVN----SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPE 794 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + + DV+S+GIVMWE+++ GE PY D+ +I I + P P C Sbjct: 795 AI--AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLP-PPMDCPA 851 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP F E+V L M +P Sbjct: 852 ALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNP 885
>LRRK1_HUMAN (Q38SD2) Leucine-rich repeat serine/threonine-protein kinase 1 (EC| 2.7.11.1) Length = 2038 Score = 80.1 bits (196), Expect = 5e-15 Identities = 55/148 (37%), Positives = 88/148 (59%), Gaps = 6/148 (4%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPI-CKVGDLGLSKVKCQTLISG--GVRGTLPWMAPELL 429 KNI+ DLKSDN+LV D + I K+ D G+S+ Q+ G GV GT + APE+ Sbjct: 1403 KNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISR---QSFHEGALGVEGTPGYQAPEIR 1459 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + EKVD+FS+G+V++ELL+G+ P A H+ I ++ +RP++ + + Q+R Sbjct: 1460 --PRIVYDEKVDMFSYGMVLYELLSGQRP-ALGHHQLQIAKKLSKGIRPVLGQPEEVQFR 1516 Query: 248 ---SLMEQCWSAEPTERPSFTEVVKRLR 174 +LM +CW +P +RP VV +++ Sbjct: 1517 RLQALMMECWDTKPEKRPLALSVVSQMK 1544
>ROS_HUMAN (P08922) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2347 Score = 80.1 bits (196), Expect = 5e-15 Identities = 52/146 (35%), Positives = 79/146 (54%), Gaps = 5/146 (3%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRP-ICKVGDLGLSK-VKCQTLISGGVRGTLP--WMAPELL 429 + +H DL + N LV+++D P I K+GD GL++ + G LP WMAPE L Sbjct: 2074 HFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESL 2133 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+SFGI++WE+LT G +PY H + V R P +C Sbjct: 2134 --MDGIFTTQSDVWSFGILIWEILTLGHQPYP-AHSNLDVLNYVQTGGRLEPPRNCPDDL 2190 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLR 174 +LM QCW+ EP +RP+F + +L+ Sbjct: 2191 WNLMTQCWAQEPDQRPTFHRIQNQLQ 2216
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 79.7 bits (195), Expect = 7e-15 Identities = 49/147 (33%), Positives = 72/147 (48%), Gaps = 3/147 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG--GVRGTLPWMAPELLN 426 KN +H DL + N LV + + KV D GLS++ + G + + W APE L Sbjct: 403 KNFIHRDLAARNCLVG----ENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL- 457 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + N S K DV++FG+++WE+ T G PY + + ++ R PE C P+ Sbjct: 458 -AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD-LLEKGYRMEQPEGCPPKVY 515 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAM 168 LM CW P +RPSF E + M Sbjct: 516 ELMRACWKWSPADRPSFAETHQAFETM 542
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 79.7 bits (195), Expect = 7e-15 Identities = 49/142 (34%), Positives = 75/142 (52%), Gaps = 1/142 (0%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGS 420 K +VH DL + N+LV+ + + KV D GL+K + + + R + W APE L Sbjct: 305 KKLVHRDLAARNILVS----EDLVAKVSDFGLAKAELRKGLDSS-RLPVKWTAPEALKNG 359 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 S K DV+SFG+++WE+ + G PY + + V R P+SC +L Sbjct: 360 R--FSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEV-SEAVEKGYRMEPPDSCPGPVHTL 416 Query: 242 MEQCWSAEPTERPSFTEVVKRL 177 M CW AEP+ RP F ++V++L Sbjct: 417 MGSCWEAEPSRRPPFRKIVEKL 438
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 79.3 bits (194), Expect = 9e-15 Identities = 50/142 (35%), Positives = 74/142 (52%), Gaps = 1/142 (0%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGS 420 K +VH DL + N+LV+ + + KV D GL+K + + L S R + W APE L Sbjct: 344 KKLVHRDLAARNILVS----EDLVAKVSDFGLAKAERKGLDSS--RLPVKWTAPEALKNG 397 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 S K DV+SFG+++WE+ + G PY + + V R P+ C +L Sbjct: 398 R--FSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEV-SEAVEKGYRMEPPDGCPGSVHTL 454 Query: 242 MEQCWSAEPTERPSFTEVVKRL 177 M CW AEP RP F ++V++L Sbjct: 455 MGSCWEAEPARRPPFRKIVEKL 476
>KRAF1_CAEEL (Q07292) Raf homolog serine/threonine-protein kinase (EC 2.7.11.1)| (Abnormal cell lineage protein 45) Length = 813 Score = 79.0 bits (193), Expect = 1e-14 Identities = 53/157 (33%), Positives = 85/157 (54%), Gaps = 10/157 (6%) Frame = -1 Query: 614 NICTGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVR-----GTLP 450 N KNI+H DLK++N+ L D + K+GD GL+ VK + ++GG + G++ Sbjct: 591 NYLHSKNIIHRDLKTNNIF--LMDDMSTV-KIGDFGLATVKTKWTVNGGQQQQQPTGSIL 647 Query: 449 WMAPELLN-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADL-HYGAIIGGIVNNTLRP-- 282 WMAPE++ N + + DV+SFGI M+E+L+ PY+++ + I+ + LRP Sbjct: 648 WMAPEVIRMQDDNPYTPQSDVYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLRPDR 707 Query: 281 -LVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLR 174 + L + C + ERP F EV++RLR Sbjct: 708 SKIRHDTPKSMLKLYDNCIMFDRNERPVFGEVLERLR 744
>MIPR_LYMST (Q25410) Putative molluscan insulin-related peptide(s) receptor| precursor (EC 2.7.10.1) [Contains: Putative molluscan insulin-related peptide(s) receptor alpha chain; Putative molluscan insulin-related peptide(s) receptor beta chain] Length = 1607 Score = 79.0 bits (193), Expect = 1e-14 Identities = 48/145 (33%), Positives = 80/145 (55%), Gaps = 4/145 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMAPELL 429 K VH DL + N +V+ + K+GD G+++ +T G +G LP WMAPE L Sbjct: 1167 KKFVHRDLAARNCMVS----EERTVKIGDFGMTRDIYETDYYRKGGKGMLPVRWMAPESL 1222 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + DV+S+G+VMWE++T +PY L ++ I + + L PE+C + Sbjct: 1223 K--DGVFTSLSDVWSYGVVMWEMVTLAAQPYQGLSNEEVVKFISDGYIMEL-PENCPNEM 1279 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRL 177 LM+ CW+ +P +RP+F +++ L Sbjct: 1280 AYLMQHCWAKKPNQRPTFKAIIEYL 1304
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 79.0 bits (193), Expect = 1e-14 Identities = 53/154 (34%), Positives = 73/154 (47%), Gaps = 7/154 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + G +P W APE Sbjct: 657 NYVHRDLAARNILVN----SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPE 712 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + DV+S+GIVMWE+++ GE PY D+ +I I + P P C Sbjct: 713 AIRYRK--FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDYRLP-PPMDCPA 769 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP F E+V L M +P Sbjct: 770 ALHQLMLDCWQKDRNSRPRFGEIVNTLDKMIRNP 803
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 79.0 bits (193), Expect = 1e-14 Identities = 52/140 (37%), Positives = 79/140 (56%), Gaps = 6/140 (4%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLS---KVKCQTLISGGVRGTLP--WMAPE 435 +N +H DL + N+LV + I KV D GL+ KV + + LP W APE Sbjct: 348 RNYIHRDLAARNVLVG----EHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPE 403 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + SN S K DV+SFGI+++E++T G+ PY+ + +I + N P P +C Sbjct: 404 AIR--SNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQ-PSNCPQ 460 Query: 257 QWRSLMEQCWSAEPTERPSF 198 Q+ ++M +CW+AEP ERP+F Sbjct: 461 QFYNIMLECWNAEPKERPTF 480
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 78.6 bits (192), Expect = 1e-14 Identities = 55/172 (31%), Positives = 86/172 (50%), Gaps = 19/172 (11%) Frame = -1 Query: 632 MLHLVWNICT--GKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVR- 462 +L ++ +C GK ++H DLK +N+LV D I K+ DLGL+ K + ++ Sbjct: 119 ILEIIEGMCYLHGKGVIHKDLKPENILV---DNDFHI-KIADLGLASFKMWSKLNNEEHN 174 Query: 461 -------------GTLPWMAPELLNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYG 321 GTL +MAPE LN + +EK DV+SF +V+W + +EPY + Sbjct: 175 ELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICE 234 Query: 320 AIIGGIVNNTLRPLV---PESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLR 174 + + + RP V E C + SLM+ CW A P RP+F + ++ R Sbjct: 235 QQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFR 286
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 78.2 bits (191), Expect = 2e-14 Identities = 45/140 (32%), Positives = 71/140 (50%) Frame = -1 Query: 605 TGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLN 426 T K ++H D+K NLL+ + IC G V ++ + RG+ WMAPE+ Sbjct: 132 TPKPLIHRDVKPLNLLLTNKGRNLKICDFGT-----VADKSTMMTNNRGSAAWMAPEVFE 186 Query: 425 GSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 GS +EK D+FS+ IV+WE+L+ ++P+ + I + RP + +C + Sbjct: 187 GSK--YTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIED 244 Query: 245 LMEQCWSAEPTERPSFTEVV 186 LM CW P +RPS +V Sbjct: 245 LMTACWKTVPEDRPSMQYIV 264
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 78.2 bits (191), Expect = 2e-14 Identities = 50/157 (31%), Positives = 80/157 (50%), Gaps = 4/157 (2%) Frame = -1 Query: 614 NICTGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ---TLISGGVRGTLPWM 444 N + N VH DL + N+LVN Q CKV D GL+++ T + G + + W Sbjct: 738 NYLSNHNYVHRDLAARNILVN----QNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWT 793 Query: 443 APELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPES 267 APE + + + + DV+SFGIVMWE+L+ G++PY ++ ++ I + P P Sbjct: 794 APEAI--AHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLP-PPVD 850 Query: 266 CDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 C LM+ CW+ + RP F ++ L + +P Sbjct: 851 CPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANP 887
>PTK7_CHICK (Q91048) Tyrosine-protein kinase-like 7 precursor (Kinase-like| protein) Length = 1051 Score = 78.2 bits (191), Expect = 2e-14 Identities = 52/141 (36%), Positives = 76/141 (53%), Gaps = 3/141 (2%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELLNGSS 417 VH DL + N LV+ QR + KV L LSK + + +P WM PE + Sbjct: 908 VHRDLAARNCLVSA---QRQV-KVSALSLSKDVYNSEYYHFRQAWIPLRWMPPEAV--LE 961 Query: 416 NLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSLM 240 + S K DV+SFG++MWE+ T GE PYA L ++ G+ + + PE C + LM Sbjct: 962 DEFSTKSDVWSFGVLMWEVFTQGEMPYAPLADDEVLAGLKSGKTKLPQPEGCPSRLTKLM 1021 Query: 239 EQCWSAEPTERPSFTEVVKRL 177 ++CW+ P +RPSF+E+ L Sbjct: 1022 QRCWAPSPKDRPSFSELAAAL 1042
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 78.2 bits (191), Expect = 2e-14 Identities = 49/147 (33%), Positives = 75/147 (51%), Gaps = 12/147 (8%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-----VKCQTLISGGVRGTLPWMAPELL 429 ++H DLK N+L++ K+ D GLSK + Q + +RG L ++ PE+ Sbjct: 141 LLHLDLKPGNILLD----SNMHVKISDFGLSKWMEQSTRMQYIERSALRGMLSYIPPEMF 196 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 S+ K DV+SF IV+WELLT ++PY+ + II + L P S QW Sbjct: 197 LESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAAGMRPSLQPVS--DQWP 254 Query: 248 S-------LMEQCWSAEPTERPSFTEV 189 S LM++CW +P +RP F ++ Sbjct: 255 SEAQQMVDLMKRCWDQDPKKRPCFLDI 281
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 77.8 bits (190), Expect = 3e-14 Identities = 52/154 (33%), Positives = 73/154 (47%), Gaps = 7/154 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + G +P W APE Sbjct: 741 NYVHRDLAARNILVN----SNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPE 796 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + DV+S+GIVMWE+++ GE PY D+ +I I + P P C Sbjct: 797 AIQYRK--FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLP-PPMDCPS 853 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP F ++V L M +P Sbjct: 854 ALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNP 887
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 77.8 bits (190), Expect = 3e-14 Identities = 52/154 (33%), Positives = 73/154 (47%), Gaps = 7/154 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + G +P W APE Sbjct: 749 NYVHRDLAARNILVN----SNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPE 804 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + DV+S+GIVMWE+++ GE PY D+ +I I + P P C Sbjct: 805 AIQYRK--FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLP-PPMDCPS 861 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP F ++V L M +P Sbjct: 862 ALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNP 895
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 77.8 bits (190), Expect = 3e-14 Identities = 54/152 (35%), Positives = 75/152 (49%), Gaps = 6/152 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV-----KCQTLISGGVRGTLPWMAPELLN 426 VH DL + N+LVN +CKV D GLS+V + +GG + + W APE + Sbjct: 755 VHRDLAARNILVN----SNLVCKVSDFGLSRVIEDDPEAVYTTTGG-KIPVRWTAPEAIQ 809 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + DV+S+GIVMWE+++ GE PY D+ +I I P P C Sbjct: 810 YRK--FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP-APMDCPAGLH 866 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 LM CW E ERP F ++V L M +P+ Sbjct: 867 QLMLDCWQKERAERPKFEQIVGILDKMIRNPS 898
>LRRK1_MOUSE (Q3UHC2) Leucine-rich repeat serine/threonine-protein kinase 1 (EC| 2.7.11.1) Length = 2014 Score = 77.8 bits (190), Expect = 3e-14 Identities = 52/148 (35%), Positives = 87/148 (58%), Gaps = 6/148 (4%) Frame = -1 Query: 599 KNIVHFDLKSDNLLV-NLRDPQRPICKVGDLGLSKVKCQTLISG--GVRGTLPWMAPELL 429 KNI+ DLKSDN+LV +L + K+ D G+S+ Q+ G GV GT + APE+ Sbjct: 1380 KNIIFCDLKSDNILVWSLSAKEHINIKLSDYGISR---QSFHEGALGVEGTPGYQAPEIR 1436 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW- 252 + EKVD+FS+G+V++ELL+G+ P H I+ + + +RP++ + + Q+ Sbjct: 1437 --PRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKKL-SKGIRPVLGQPEEVQFH 1493 Query: 251 --RSLMEQCWSAEPTERPSFTEVVKRLR 174 ++LM +CW +P +RP VV +++ Sbjct: 1494 RLQALMMECWDTKPEKRPLALSVVSQMK 1521
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 77.8 bits (190), Expect = 3e-14 Identities = 49/151 (32%), Positives = 81/151 (53%), Gaps = 3/151 (1%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK--VKCQTLISGGVRGTLPWMAPELLNG 423 N +H DL + N LV + + KV D GL++ + Q SGG + + W PE+LN Sbjct: 642 NYIHRDLAARNCLVGSEN----VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNY 697 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + S K DV+++G++MWE+ T G+ PY L ++ + + P+SC + Sbjct: 698 TR--FSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEK-PKSCAKEIYD 754 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 +M+ CWS P ERP+F ++ +L +A + T Sbjct: 755 VMKLCWSHGPEERPAFRVLMDQLALVAQTLT 785
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 77.8 bits (190), Expect = 3e-14 Identities = 47/150 (31%), Positives = 79/150 (52%), Gaps = 3/150 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG--GVRGTLPWMAPELLN 426 ++ +H DL + N LV+ + I K+ D GL++ + + G + + W APE L Sbjct: 426 RHFIHRDLAARNCLVS----EHNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAPEGL- 480 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + N S K DV++FG+++WE+ T G PY + + G ++ N R P+ C P Sbjct: 481 -AFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYG-LLENGFRMDGPQGCPPSVY 538 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATS 159 LM QCW+ P++RP F ++ L + +S Sbjct: 539 RLMLQCWNWSPSDRPRFRDIHFNLENLISS 568
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 77.8 bits (190), Expect = 3e-14 Identities = 48/146 (32%), Positives = 78/146 (53%), Gaps = 11/146 (7%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-----VKCQTLISGGVRGTLPWMAPELL 429 ++H DLK N+L++ K+ D GLSK + Q + +RGTL ++ PE+ Sbjct: 153 LLHLDLKPGNILLD----NNMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYIPPEMF 208 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDP--- 258 ++ + DV+SF IV+WE+LT ++PYA L+ II + +RP + + D Sbjct: 209 LENNKAPGPEYDVYSFAIVIWEILTQKKPYAGLNMMTIIIRVAAG-MRPSLQDVSDEWPE 267 Query: 257 ---QWRSLMEQCWSAEPTERPSFTEV 189 Q +LM++CW +P +RP F V Sbjct: 268 EVHQMVNLMKRCWDQDPKKRPCFLNV 293
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 77.4 bits (189), Expect = 3e-14 Identities = 52/154 (33%), Positives = 73/154 (47%), Gaps = 7/154 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + G +P W APE Sbjct: 759 NYVHRDLAARNILVN----SNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPE 814 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + DV+S+GIVMWE+++ GE PY D+ +I I + P P C Sbjct: 815 AIQYRK--FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLP-PPMDCPN 871 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP F ++V L M +P Sbjct: 872 ALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNP 905
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 77.4 bits (189), Expect = 3e-14 Identities = 51/150 (34%), Positives = 73/150 (48%), Gaps = 5/150 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 +H DL + N+LV+ R +CKV D GLS+ + G + + W APE + Sbjct: 124 IHRDLAARNILVD----GRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAI-- 177 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + S DV+SFG+VMWE+L GE PY ++ +I + P P C Sbjct: 178 AFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEGYRLP-APMGCPRALHQ 236 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + +RP F+ VV L A+ SP Sbjct: 237 LMLDCWHKDRAQRPRFSHVVSVLEALVHSP 266
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 77.4 bits (189), Expect = 3e-14 Identities = 53/160 (33%), Positives = 89/160 (55%), Gaps = 10/160 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGG-----VRGTLPWMAPE 435 K+I+H DLKS+N+ ++ + K+GD GL+ VK + SG + G++ WMAPE Sbjct: 610 KSIIHRDLKSNNIFLH----EDLTVKIGDFGLATVKSRW--SGSHQFEQLSGSILWMAPE 663 Query: 434 LLN-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADL-HYGAIIGGIVNNTLRP---LVPE 270 ++ N S + DV++FGIV++EL+TG+ PY+++ + II + L P V Sbjct: 664 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 723 Query: 269 SCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTK 150 +C + LM +C + ERP F +++ + +A S K Sbjct: 724 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK 763
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 77.4 bits (189), Expect = 3e-14 Identities = 53/160 (33%), Positives = 89/160 (55%), Gaps = 10/160 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGG-----VRGTLPWMAPE 435 K+I+H DLKS+N+ ++ + K+GD GL+ VK + SG + G++ WMAPE Sbjct: 196 KSIIHRDLKSNNIFLH----EDLTVKIGDFGLATVKSRW--SGSHQFEQLSGSILWMAPE 249 Query: 434 LLN-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADL-HYGAIIGGIVNNTLRP---LVPE 270 ++ N S + DV++FGIV++EL+TG+ PY+++ + II + L P V Sbjct: 250 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 309 Query: 269 SCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTK 150 +C + LM +C + ERP F +++ + +A S K Sbjct: 310 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK 349
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 77.4 bits (189), Expect = 3e-14 Identities = 53/160 (33%), Positives = 89/160 (55%), Gaps = 10/160 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGG-----VRGTLPWMAPE 435 K+I+H DLKS+N+ ++ + K+GD GL+ VK + SG + G++ WMAPE Sbjct: 180 KSIIHRDLKSNNIFLH----EDLTVKIGDFGLATVKSRW--SGSHQFEQLSGSILWMAPE 233 Query: 434 LLN-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADL-HYGAIIGGIVNNTLRP---LVPE 270 ++ N S + DV++FGIV++EL+TG+ PY+++ + II + L P V Sbjct: 234 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 293 Query: 269 SCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTK 150 +C + LM +C + ERP F +++ + +A S K Sbjct: 294 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK 333
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 77.4 bits (189), Expect = 3e-14 Identities = 54/151 (35%), Positives = 74/151 (49%), Gaps = 6/151 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV-----KCQTLISGGVRGTLPWMAPELLN 426 VH DL + N+LVN +CKV D GLS+V + +GG + + W APE + Sbjct: 755 VHRDLAARNILVN----SNLVCKVSDFGLSRVIEDDPEAVYTTTGG-KIPVRWTAPEAIQ 809 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + DV+S+GIVMWE+++ GE PY D+ +I I P P C Sbjct: 810 YRK--FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP-APMDCPAGLH 866 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW E ERP F ++V L M +P Sbjct: 867 QLMLDCWQKERAERPKFEQIVGILDKMIRNP 897
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 77.4 bits (189), Expect = 3e-14 Identities = 53/160 (33%), Positives = 89/160 (55%), Gaps = 10/160 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGG-----VRGTLPWMAPE 435 K+I+H DLKS+N+ ++ + K+GD GL+ VK + SG + G++ WMAPE Sbjct: 570 KSIIHRDLKSNNIFLH----EDLTVKIGDFGLATVKSRW--SGSHQFEQLSGSILWMAPE 623 Query: 434 LLN-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADL-HYGAIIGGIVNNTLRP---LVPE 270 ++ N S + DV++FGIV++EL+TG+ PY+++ + II + L P V Sbjct: 624 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 683 Query: 269 SCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTK 150 +C + LM +C + ERP F +++ + +A S K Sbjct: 684 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK 723
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 77.4 bits (189), Expect = 3e-14 Identities = 52/154 (33%), Positives = 73/154 (47%), Gaps = 7/154 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + G +P W APE Sbjct: 739 NYVHRDLAARNILVN----SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPE 794 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + + DV+S+GIVMWE+++ GE PY D+ +I I + P P C Sbjct: 795 AI--AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLP-PPMDCPA 851 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP E+V L M +P Sbjct: 852 ALHQLMLDCWQKDRNTRPRLAEIVNTLDKMIRNP 885
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 77.4 bits (189), Expect = 3e-14 Identities = 53/160 (33%), Positives = 89/160 (55%), Gaps = 10/160 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGG-----VRGTLPWMAPE 435 K+I+H DLKS+N+ ++ + K+GD GL+ VK + SG + G++ WMAPE Sbjct: 132 KSIIHRDLKSNNIFLH----EDLTVKIGDFGLATVKSRW--SGSHQFEQLSGSILWMAPE 185 Query: 434 LLN-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADL-HYGAIIGGIVNNTLRP---LVPE 270 ++ N S + DV++FGIV++EL+TG+ PY+++ + II + L P V Sbjct: 186 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 245 Query: 269 SCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTK 150 +C + LM +C + ERP F +++ + +A S K Sbjct: 246 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK 285
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 77.4 bits (189), Expect = 3e-14 Identities = 53/159 (33%), Positives = 76/159 (47%), Gaps = 14/159 (8%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ-------------TLISGGVRGTLP 450 VH DL + N+LVN +CKV D G+S+V + T S G + + Sbjct: 117 VHRDLAARNILVN----SNLVCKVSDFGMSRVLEEDPDAAYTTREITGTYQSQGGKIPIR 172 Query: 449 WMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVP 273 W APE + + + DV+S+GIVMWE+++ GE PY D+ +I I P P Sbjct: 173 WTAPEAI--TYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP-PP 229 Query: 272 ESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 C LM CW E ERP F+++V L + +P Sbjct: 230 MDCPVSLHQLMLDCWQKERAERPKFSQIVNMLDKLIRNP 268
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 77.4 bits (189), Expect = 3e-14 Identities = 53/160 (33%), Positives = 89/160 (55%), Gaps = 10/160 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGG-----VRGTLPWMAPE 435 K+I+H DLKS+N+ ++ + K+GD GL+ VK + SG + G++ WMAPE Sbjct: 610 KSIIHRDLKSNNIFLH----EDLTVKIGDFGLATVKSRW--SGSHQFEQLSGSILWMAPE 663 Query: 434 LLN-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADL-HYGAIIGGIVNNTLRP---LVPE 270 ++ N S + DV++FGIV++EL+TG+ PY+++ + II + L P V Sbjct: 664 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 723 Query: 269 SCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTK 150 +C + LM +C + ERP F +++ + +A S K Sbjct: 724 NCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK 763
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 77.0 bits (188), Expect = 4e-14 Identities = 52/152 (34%), Positives = 74/152 (48%), Gaps = 7/152 (4%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV------KCQTLISGGVRGTLPWMAPELL 429 VH DL + N+LV+ +CKV D GLS+V T G + + W APE + Sbjct: 757 VHRDLAARNVLVD----SNLVCKVSDFGLSRVLEDDPDAAYTTTGGKI--PIRWTAPEAI 810 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + S DV+SFG+VMWE+L GE PY ++ +I + P P C Sbjct: 811 --AFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLP-APMGCPHAL 867 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + +RP F+++V L A+ SP Sbjct: 868 HQLMLDCWHKDRAQRPRFSQIVSVLDALIRSP 899
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 77.0 bits (188), Expect = 4e-14 Identities = 48/147 (32%), Positives = 73/147 (49%), Gaps = 3/147 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG--GVRGTLPWMAPELLN 426 KN +H DL + N LV + + KV D GLS++ + G + + W APE L Sbjct: 243 KNFIHRDLAARNCLVG----ENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL- 297 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + N S K DV++FG+++WE+ T G PY + + ++ R PE C + Sbjct: 298 -AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE-LLEKDYRMERPEGCPEKVY 355 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAM 168 LM CW P++RPSF E+ + M Sbjct: 356 ELMRACWQWNPSDRPSFAEIHQAFETM 382
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 77.0 bits (188), Expect = 4e-14 Identities = 48/147 (32%), Positives = 73/147 (49%), Gaps = 3/147 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG--GVRGTLPWMAPELLN 426 KN +H DL + N LV + + KV D GLS++ + G + + W APE L Sbjct: 357 KNFIHRDLAARNCLVG----ENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL- 411 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + N S K DV++FG+++WE+ T G PY + + ++ R PE C + Sbjct: 412 -AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE-LLEKDYRMERPEGCPEKVY 469 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAM 168 LM CW P++RPSF E+ + M Sbjct: 470 ELMRACWQWNPSDRPSFAEIHQAFETM 496
>ZAP70_HUMAN (P43403) Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa| zeta-associated protein) (Syk-related tyrosine kinase) Length = 619 Score = 77.0 bits (188), Expect = 4e-14 Identities = 55/150 (36%), Positives = 75/150 (50%), Gaps = 7/150 (4%) Frame = -1 Query: 599 KNIVHFDLKSDN-LLVNLRDPQRPICKVGDLGLSKV-----KCQTLISGGVRGTLPWMAP 438 KN VH DL + N LLVN R K+ D GLSK T S G + L W AP Sbjct: 455 KNFVHRDLAARNVLLVN-----RHYAKISDFGLSKALGADDSYYTARSAG-KWPLKWYAP 508 Query: 437 ELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCD 261 E +N S + DV+S+G+ MWE L+ G++PY + G + + R P C Sbjct: 509 ECINFRK--FSSRSDVWSYGVTMWEALSYGQKPYKKMK-GPEVMAFIEQGKRMECPPECP 565 Query: 260 PQWRSLMEQCWSAEPTERPSFTEVVKRLRA 171 P+ +LM CW + +RP F V +R+RA Sbjct: 566 PELYALMSDCWIYKWEDRPDFLTVEQRMRA 595
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 77.0 bits (188), Expect = 4e-14 Identities = 53/155 (34%), Positives = 75/155 (48%), Gaps = 7/155 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ +G + +P W APE Sbjct: 757 NYVHRDLAARNILVN----SNLVCKVSDFGLSRFLEDDASNPTYTGALGCKIPIRWTAPE 812 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + S DV+S+GIVMWE+++ GE PY D+ +I I + P P+ C Sbjct: 813 AVQYRKFTSSS--DVWSYGIVMWEVMSYGERPYWDMSNQDVINAIDQDYRLPPPPD-CPT 869 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 LM CW + +RP F ++V L M P+ Sbjct: 870 VLHLLMLDCWQKDRVQRPKFEQIVSALDKMIRKPS 904
>EPHA6_HUMAN (Q9UF33) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 77.0 bits (188), Expect = 4e-14 Identities = 52/152 (34%), Positives = 75/152 (49%), Gaps = 6/152 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV-----KCQTLISGGVRGTLPWMAPELLN 426 VH DL + N+LVN +CKV D GLS+V + +GG + + W APE + Sbjct: 794 VHRDLAARNILVN----SNLVCKVSDFGLSRVLEDDPEAAYTTTGG-KIPIRWTAPEAI- 847 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + S D +S+GIVMWE+++ GE PY ++ +I I P P C Sbjct: 848 -AYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLP-APMGCPASLH 905 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 LM CW E RP FT++V L + +P+ Sbjct: 906 QLMLHCWQKERNHRPKFTDIVSFLDKLIRNPS 937
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 77.0 bits (188), Expect = 4e-14 Identities = 51/147 (34%), Positives = 73/147 (49%), Gaps = 7/147 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + + G +P W APE Sbjct: 729 NYVHRDLAARNILVN----SNLVCKVSDFGLSRFLENSRSDPTYTSALGGKIPIRWTAPE 784 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + S + DV+S+GIVMWE+++ GE PY D+ +I I + P P C Sbjct: 785 AI--SYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDYRLP-PPMDCPS 841 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRL 177 LM CW + RP F+++V L Sbjct: 842 ALHQLMLDCWLRDRNLRPKFSQIVSSL 868
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 77.0 bits (188), Expect = 4e-14 Identities = 48/147 (32%), Positives = 73/147 (49%), Gaps = 3/147 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG--GVRGTLPWMAPELLN 426 KN +H DL + N LV + + KV D GLS++ + G + + W APE L Sbjct: 357 KNFIHRDLAARNCLVG----ENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL- 411 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + N S K DV++FG+++WE+ T G PY + + ++ R PE C + Sbjct: 412 -AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE-LLEKDYRMERPEGCPEKVY 469 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAM 168 LM CW P++RPSF E+ + M Sbjct: 470 ELMRACWQWNPSDRPSFAEIHQAFETM 496
>TYRO3_HUMAN (Q06418) Tyrosine-protein kinase receptor TYRO3 precursor (EC| 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase DTK) (Protein-tyrosine kinase byk) Length = 890 Score = 75.9 bits (185), Expect(2) = 5e-14 Identities = 54/145 (37%), Positives = 77/145 (53%), Gaps = 8/145 (5%) Frame = -1 Query: 605 TGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLS-KVKCQTLISGGVRGTLP--WMAPE 435 + +N +H DL + N ++ +C V D GLS K+ G LP W+A E Sbjct: 647 SSRNFIHRDLAARNCMLA---EDMTVC-VADFGLSRKIYSGDYYRQGCASKLPVKWLALE 702 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLH----YGAIIGGIVNNTLRPLVPE 270 L + NL + + DV++FG+ MWE++T G+ PYA + Y +IGG N L+ P Sbjct: 703 SL--ADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGG---NRLKQ--PP 755 Query: 269 SCDPQWRSLMEQCWSAEPTERPSFT 195 C LM QCWSA+P +RPSFT Sbjct: 756 ECMEDVYDLMYQCWSADPKQRPSFT 780 Score = 21.2 bits (43), Expect(2) = 5e-14 Identities = 7/15 (46%), Positives = 11/15 (73%) Frame = -3 Query: 636 MDVAFGMEYLHGKEY 592 +D+A GMEYL + + Sbjct: 637 VDIACGMEYLSSRNF 651
>TYRO3_MOUSE (P55144) Tyrosine-protein kinase receptor TYRO3 precursor (EC| 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3) Length = 880 Score = 75.9 bits (185), Expect(2) = 5e-14 Identities = 54/145 (37%), Positives = 77/145 (53%), Gaps = 8/145 (5%) Frame = -1 Query: 605 TGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLS-KVKCQTLISGGVRGTLP--WMAPE 435 + +N +H DL + N ++ +C V D GLS K+ G LP W+A E Sbjct: 637 SSRNFIHRDLAARNCMLA---EDMTVC-VADFGLSRKIYSGDYYRQGCASKLPVKWLALE 692 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLH----YGAIIGGIVNNTLRPLVPE 270 L + NL + DV++FG+ MWE++T G+ PYA + Y +IGG N L+ P Sbjct: 693 SL--ADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGG---NRLKQ--PP 745 Query: 269 SCDPQWRSLMEQCWSAEPTERPSFT 195 C + LM QCWSA+P +RPSFT Sbjct: 746 ECMEEVYDLMYQCWSADPKQRPSFT 770 Score = 21.2 bits (43), Expect(2) = 5e-14 Identities = 7/15 (46%), Positives = 11/15 (73%) Frame = -3 Query: 636 MDVAFGMEYLHGKEY 592 +D+A GMEYL + + Sbjct: 627 VDIACGMEYLSSRNF 641
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 76.6 bits (187), Expect = 6e-14 Identities = 53/152 (34%), Positives = 75/152 (49%), Gaps = 6/152 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV-----KCQTLISGGVRGTLPWMAPELLN 426 VH DL + N+LVN +CKV D GLS+V + +GG + + W APE + Sbjct: 755 VHRDLAARNILVN----SNLVCKVSDFGLSRVIEDDPEAVYTTTGG-KIPVRWTAPEAIQ 809 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + DV+S+GIVMWE+++ GE PY D+ +I I P P C Sbjct: 810 YRK--FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP-APMDCPAGLH 866 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 LM CW + ERP F ++V L M +P+ Sbjct: 867 QLMLDCWQKDRAERPKFEQIVGILDKMIRNPS 898
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 76.6 bits (187), Expect = 6e-14 Identities = 54/151 (35%), Positives = 74/151 (49%), Gaps = 6/151 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV-----KCQTLISGGVRGTLPWMAPELLN 426 VH DL + N+LVN +CKV D GLS+V + +GG + + W APE + Sbjct: 750 VHRDLAARNILVN----SNLVCKVSDFGLSRVIEDDPEAVYTTTGG-KIPVRWTAPEAIQ 804 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + DV+S+GIVMWE+++ GE PY D+ +I I P P C Sbjct: 805 YRK--FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP-APMDCPAGLH 861 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW E ERP F ++V L M +P Sbjct: 862 QLMLDCWQKERGERPKFEQIVGILDKMIRNP 892
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 76.6 bits (187), Expect = 6e-14 Identities = 46/137 (33%), Positives = 72/137 (52%), Gaps = 3/137 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG--GVRGTLPWMAPELLN 426 +N +H DL + N+LV + ICKV D GL++V + + G + + W APE Sbjct: 353 QNYIHRDLAARNILVG----EHGICKVADFGLARVIDEEIYEAHTGAKFPIKWTAPEA-- 406 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 N + K DV+SFG+V++E++T G PY + ++ I N P P +C Q+ Sbjct: 407 AMYNRFTIKSDVWSFGVVLYEIITYGRFPYPGMTNPEVLEKIQQNYRMPC-PANCPKQFH 465 Query: 248 SLMEQCWSAEPTERPSF 198 +M CW +P RP+F Sbjct: 466 DIMLDCWREDPASRPTF 482
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 73.9 bits (180), Expect(2) = 6e-14 Identities = 51/142 (35%), Positives = 73/142 (51%), Gaps = 3/142 (2%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVR---GTLPWMAPELLNG 423 I+H DL S N+L+ + V D G S+ Q+L + G L WMAPE+ Sbjct: 583 IIHRDLNSHNILLY----EDGHAVVADFGESRF-LQSLDEDNMTKQPGNLRWMAPEVFTQ 637 Query: 422 SSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 + K DVFS+ + +WELLTGE P+A L A + + +RP + S SL Sbjct: 638 CTRYTI-KADVFSYSLCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSL 696 Query: 242 MEQCWSAEPTERPSFTEVVKRL 177 + + W+A P RP F+EVV +L Sbjct: 697 LIRGWNACPEGRPEFSEVVSKL 718 Score = 22.7 bits (47), Expect(2) = 6e-14 Identities = 9/11 (81%), Positives = 10/11 (90%) Frame = -3 Query: 636 MDVAFGMEYLH 604 +DVA GMEYLH Sbjct: 567 VDVAKGMEYLH 577
>EPHB4_HUMAN (P54760) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HTK) Length = 987 Score = 76.3 bits (186), Expect = 7e-14 Identities = 51/152 (33%), Positives = 73/152 (48%), Gaps = 7/152 (4%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPELL 429 VH DL + N+LVN +CKV D GLS+ + + G +P W APE + Sbjct: 737 VHRDLAARNILVN----SNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAI 792 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + D +S+GIVMWE+++ GE PY D+ +I I + P P+ C Sbjct: 793 --AFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPD-CPTSL 849 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP F +VV L M +P Sbjct: 850 HQLMLDCWQKDRNARPRFPQVVSALDKMIRNP 881
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 76.3 bits (186), Expect = 7e-14 Identities = 52/154 (33%), Positives = 72/154 (46%), Gaps = 7/154 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N LVN +CKV D GLS+ + + G +P W APE Sbjct: 742 NYVHRDLAARNTLVN----SNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPE 797 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + DV+S+GIVMWE+++ GE PY D+ +I I + P P C Sbjct: 798 AIQYRK--FTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLP-PPMDCPN 854 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP F ++V L M +P Sbjct: 855 ALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNP 888
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 76.3 bits (186), Expect = 7e-14 Identities = 51/152 (33%), Positives = 74/152 (48%), Gaps = 1/152 (0%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGS 420 K +VH DL + N+LV+ + + KV D GL+K + + L S R + W APE L Sbjct: 346 KKLVHRDLAARNILVS----EDLVAKVSDFGLAKAERKGLDSS--RLPVKWTAPEALKHG 399 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 + K DV+SFG+++WE+ + G PY + + V R PE C L Sbjct: 400 K--FTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEV-SEAVEKGYRMEPPEGCPGPVHVL 456 Query: 242 MEQCWSAEPTERPSFTEVVKRLRAMATSPTKP 147 M CW AEP RP F ++ ++L S P Sbjct: 457 MSSCWEAEPARRPPFRKLAEKLARELRSAGAP 488
>HCK_MACFA (Q95M30) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 503 Score = 76.3 bits (186), Expect = 7e-14 Identities = 44/137 (32%), Positives = 75/137 (54%), Gaps = 3/137 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPELLN 426 +N +H DL++ N+LV+ +CK+ D GL+++ + G + + W APE +N Sbjct: 352 RNYIHRDLRAANILVSAS----LVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAIN 407 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 S+ + K DV+SFGI++ E++T G PY + +I + P PE+C + Sbjct: 408 FGSSTI--KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPR-PENCPEELY 464 Query: 248 SLMEQCWSAEPTERPSF 198 ++M +CW P ERP+F Sbjct: 465 NIMMRCWKNRPEERPTF 481
>KIT_MOUSE (P05532) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 975 Score = 76.3 bits (186), Expect = 7e-14 Identities = 46/154 (29%), Positives = 79/154 (51%), Gaps = 4/154 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV---KCQTLISGGVRGTLPWMAPELL 429 KN +H DL + N+L+ I K+ D GL++ ++ G R + WMAPE + Sbjct: 784 KNCIHRDLAARNILLT----HGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESI 839 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 S + + + DV+S+GI +WEL + G PY + + ++ R + PE + Sbjct: 840 --FSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVSPEHAPAEM 897 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTK 150 +M+ CW A+P +RP+F +VV+ + + TK Sbjct: 898 YDVMKTCWDADPLKRPTFKQVVQLIEKQISDSTK 931
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC 2.7.10.2)| (C-FES) Length = 820 Score = 76.3 bits (186), Expect = 7e-14 Identities = 51/148 (34%), Positives = 78/148 (52%), Gaps = 4/148 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLI--SGGVRGT-LPWMAPELL 429 K +H DL + N LV ++ + K+ D G+S+ + + SGG+R + W APE L Sbjct: 675 KCCIHRDLAARNCLVT----EKNVLKISDFGMSREEADGIYAASGGLRQVPVKWTAPEAL 730 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 N S + DV+SFGI++WE + G PY +L + P PE C Sbjct: 731 NYGR--YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC-PELCPDAV 787 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAM 168 LMEQCW+ EP +RPSF+ + + L+++ Sbjct: 788 FRLMEQCWAYEPGQRPSFSAIYQELQSI 815
>TYRO3_RAT (P55146) Tyrosine-protein kinase receptor TYRO3 precursor (EC| 2.7.10.1) (Tyrosine-protein kinase SKY) Length = 880 Score = 75.1 bits (183), Expect(2) = 8e-14 Identities = 50/141 (35%), Positives = 74/141 (52%), Gaps = 4/141 (2%) Frame = -1 Query: 605 TGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLS-KVKCQTLISGGVRGTLP--WMAPE 435 + +N +H DL + N ++ +C V D GLS K+ G LP W+A E Sbjct: 637 SSRNFIHRDLAARNCMLA---EDMTVC-VADFGLSRKIYSGDYYRQGCASKLPVKWLALE 692 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 L + NL + DV++FG+ MWE++T G+ PYA + I +++ R P C Sbjct: 693 SL--ADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLISGN-RLKQPPECME 749 Query: 257 QWRSLMEQCWSAEPTERPSFT 195 + LM QCWSA+P +RPSFT Sbjct: 750 EVYDLMYQCWSADPKQRPSFT 770 Score = 21.2 bits (43), Expect(2) = 8e-14 Identities = 7/15 (46%), Positives = 11/15 (73%) Frame = -3 Query: 636 MDVAFGMEYLHGKEY 592 +D+A GMEYL + + Sbjct: 627 VDIACGMEYLSSRNF 641
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 75.9 bits (185), Expect = 1e-13 Identities = 51/150 (34%), Positives = 72/150 (48%), Gaps = 5/150 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 +H DL + N+LV+ R +CKV D GLS+ + G + + W APE + Sbjct: 756 IHRDLAARNVLVD----GRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAI-- 809 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + S DV+SFG+VMWE+L GE PY ++ +I + P P C Sbjct: 810 AFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEGYRLP-APMGCPRALHQ 868 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + +RP F VV L A+ SP Sbjct: 869 LMLDCWHKDRAQRPRFAHVVSVLDALVHSP 898
>INSR_XENLA (Q9PVZ4) Insulin receptor precursor (EC 2.7.10.1) (IR) (Xe-InsR)| (XTK-1b) [Contains: Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1362 Score = 75.9 bits (185), Expect = 1e-13 Identities = 50/151 (33%), Positives = 79/151 (52%), Gaps = 9/151 (5%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMAPELL 429 K VH DL + N +V K+GD G+++ +T G +G LP WM+PE L Sbjct: 1142 KKFVHRDLAARNCMV----ADDYAVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESL 1197 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAII-----GGIVNNTLRPLVPES 267 + + DV+SFG+V+WE+ + E+PY L ++ GG +++ PE+ Sbjct: 1198 K--DGVFTAFSDVWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGSLDH------PEN 1249 Query: 266 CDPQWRSLMEQCWSAEPTERPSFTEVVKRLR 174 C P+ SLM+ CW P RP+F E++ L+ Sbjct: 1250 CPPRLHSLMQMCWQYNPKMRPTFLEIIDMLK 1280
>VGFR2_BRARE (Q8AXB3) Vascular endothelial growth factor receptor 2 precursor (EC| 2.7.10.1) (VEGFR-2) (Receptor tyrosine kinase flk-1) Length = 1302 Score = 75.9 bits (185), Expect = 1e-13 Identities = 46/145 (31%), Positives = 75/145 (51%), Gaps = 4/145 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT---LISGGVRGTLPWMAPELL 429 + +H DL + N+L++ + + K+ D GL++ + + G R L WMAPE + Sbjct: 997 RKCIHRDLAARNILLS----ENNVVKICDFGLARDVYKDPDYVRKGDARLPLKWMAPEAI 1052 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+SFG++MWE+ + G PY LH + R PE + Sbjct: 1053 --FDKIYTTQSDVWSFGVLMWEIFSLGASPYPGLHIDEEFCCRLKEGTRMKAPEYSSSEI 1110 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRL 177 M CW EP++RP+FTE+V+RL Sbjct: 1111 YQTMLDCWHGEPSQRPTFTELVERL 1135
>KIT_HUMAN (P10721) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen) Length = 976 Score = 75.5 bits (184), Expect = 1e-13 Identities = 45/153 (29%), Positives = 77/153 (50%), Gaps = 4/153 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLS---KVKCQTLISGGVRGTLPWMAPELL 429 KN +H DL + N+L+ I K+ D GL+ K ++ G R + WMAPE + Sbjct: 786 KNCIHRDLAARNILLT----HGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESI 841 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+S+GI +WEL + G PY + + ++ R L PE + Sbjct: 842 FNC--VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEM 899 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 +M+ CW A+P +RP+F ++V+ + + T Sbjct: 900 YDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
>FES_FSVGA (P00542) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 609 Score = 75.5 bits (184), Expect = 1e-13 Identities = 51/148 (34%), Positives = 77/148 (52%), Gaps = 4/148 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLI--SGGVRGT-LPWMAPELL 429 K +H DL + N LV ++ + K+ D G+S+ + SGG+R + W APE L Sbjct: 464 KCCIHRDLAARNCLVT----EKNVLKISDFGMSREAADGIYAASGGLRQVPVKWTAPEAL 519 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 N S + DV+SFGI++WE + G PY +L + P PE C Sbjct: 520 NYGR--YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC-PELCPDAV 576 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAM 168 LMEQCW+ EP +RPSF+ + + L+++ Sbjct: 577 FRLMEQCWAYEPGQRPSFSAIYQELQSI 604
>KIT_CHICK (Q08156) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 960 Score = 75.5 bits (184), Expect = 1e-13 Identities = 43/143 (30%), Positives = 75/143 (52%), Gaps = 4/143 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV---KCQTLISGGVRGTLPWMAPELL 429 KN +H DL + N+L+ I K+ D GL++ ++ G R + WMAPE + Sbjct: 771 KNCIHRDLAARNILLT----HGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESI 826 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+S+GI++WEL + G PY + + ++ R PE P+ Sbjct: 827 FNC--VYTFESDVWSYGILLWELFSLGSSPYPGMPVDSKFYKMIKEGYRMFSPECSPPEM 884 Query: 251 RSLMEQCWSAEPTERPSFTEVVK 183 +M+ CW A+P +RP+F ++V+ Sbjct: 885 YDIMKSCWDADPLQRPTFKQIVQ 907
>KIT_CANFA (O97799) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 975 Score = 75.5 bits (184), Expect = 1e-13 Identities = 45/153 (29%), Positives = 77/153 (50%), Gaps = 4/153 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLS---KVKCQTLISGGVRGTLPWMAPELL 429 KN +H DL + N+L+ I K+ D GL+ K ++ G R + WMAPE + Sbjct: 785 KNCIHRDLAARNILLT----HGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESI 840 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+S+GI +WEL + G PY + + ++ R L PE + Sbjct: 841 FNC--VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEM 898 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 +M+ CW A+P +RP+F ++V+ + + T Sbjct: 899 YDIMKTCWDADPLKRPTFKQIVQLIEKQISDST 931
>KIT_FELCA (Q28889) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 978 Score = 75.5 bits (184), Expect = 1e-13 Identities = 45/153 (29%), Positives = 77/153 (50%), Gaps = 4/153 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLS---KVKCQTLISGGVRGTLPWMAPELL 429 KN +H DL + N+L+ I K+ D GL+ K ++ G R + WMAPE + Sbjct: 787 KNCIHRDLAARNILLT----HGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESI 842 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+S+GI +WEL + G PY + + ++ R L PE + Sbjct: 843 FNC--VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEM 900 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 +M+ CW A+P +RP+F ++V+ + + T Sbjct: 901 YDIMKTCWDADPLKRPTFKQIVQLIEKQISDST 933
>KIT_CAPHI (Q28317) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 978 Score = 75.5 bits (184), Expect = 1e-13 Identities = 45/153 (29%), Positives = 77/153 (50%), Gaps = 4/153 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLS---KVKCQTLISGGVRGTLPWMAPELL 429 KN +H DL + N+L+ I K+ D GL+ K ++ G R + WMAPE + Sbjct: 788 KNCIHRDLAARNILLT----HGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESI 843 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+S+GI +WEL + G PY + + ++ R L PE + Sbjct: 844 FNC--VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEM 901 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 +M+ CW A+P +RP+F ++V+ + + T Sbjct: 902 YDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 934
>INSRR_HUMAN (P14616) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1297 Score = 75.5 bits (184), Expect = 1e-13 Identities = 52/165 (31%), Positives = 84/165 (50%), Gaps = 10/165 (6%) Frame = -1 Query: 638 GWMLHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-L 480 G M+ + I G VH DL + N +V+ Q K+GD G+++ +T Sbjct: 1090 GEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVS----QDFTVKIGDFGMTRDVYETDY 1145 Query: 479 ISGGVRGTLP--WMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIG 309 G +G LP WMAPE L + + DV+SFG+V+WE++T E+PY L ++ Sbjct: 1146 YRKGGKGLLPVRWMAPESLK--DGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLK 1203 Query: 308 GIVNNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLR 174 +++ + + E C Q + LM +CW P RPSFT ++ ++ Sbjct: 1204 FVMDGGVLEEL-EGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ 1247
>KIT_BOVIN (P43481) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 977 Score = 75.5 bits (184), Expect = 1e-13 Identities = 45/153 (29%), Positives = 77/153 (50%), Gaps = 4/153 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLS---KVKCQTLISGGVRGTLPWMAPELL 429 KN +H DL + N+L+ I K+ D GL+ K ++ G R + WMAPE + Sbjct: 787 KNCIHRDLAARNILLT----HGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESI 842 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+S+GI +WEL + G PY + + ++ R L PE + Sbjct: 843 FNC--VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEM 900 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 +M+ CW A+P +RP+F ++V+ + + T Sbjct: 901 YDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 933
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 72.8 bits (177), Expect(2) = 1e-13 Identities = 50/142 (35%), Positives = 73/142 (51%), Gaps = 3/142 (2%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVR---GTLPWMAPELLNG 423 I+H DL S N+L+ + V D G S+ Q+L + G L WMAPE+ Sbjct: 685 IIHRDLNSHNILLY----EDGHAVVADFGESRF-LQSLDEDNMTKQPGNLRWMAPEVFTQ 739 Query: 422 SSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 + K DVFS+ + +WE+LTGE P+A L A + + +RP + S SL Sbjct: 740 CTRYTI-KADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSL 798 Query: 242 MEQCWSAEPTERPSFTEVVKRL 177 + + W+A P RP F+EVV +L Sbjct: 799 LIRGWNACPEGRPEFSEVVMKL 820 Score = 22.7 bits (47), Expect(2) = 1e-13 Identities = 9/11 (81%), Positives = 10/11 (90%) Frame = -3 Query: 636 MDVAFGMEYLH 604 +DVA GMEYLH Sbjct: 669 VDVAKGMEYLH 679
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 72.8 bits (177), Expect(2) = 1e-13 Identities = 50/142 (35%), Positives = 73/142 (51%), Gaps = 3/142 (2%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVR---GTLPWMAPELLNG 423 I+H DL S N+L+ + V D G S+ Q+L + G L WMAPE+ Sbjct: 582 IIHRDLNSHNILLY----EDGHAVVADFGESRF-LQSLDEDNMTKQPGNLRWMAPEVFTQ 636 Query: 422 SSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 + K DVFS+ + +WELL GE P+A L A + + +RP + S SL Sbjct: 637 CTRYTI-KADVFSYALCLWELLIGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSL 695 Query: 242 MEQCWSAEPTERPSFTEVVKRL 177 + + W+A P RP F+EVV++L Sbjct: 696 LMRGWNACPEGRPEFSEVVRKL 717 Score = 22.7 bits (47), Expect(2) = 1e-13 Identities = 9/11 (81%), Positives = 10/11 (90%) Frame = -3 Query: 636 MDVAFGMEYLH 604 +DVA GMEYLH Sbjct: 566 VDVAKGMEYLH 576
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 75.1 bits (183), Expect = 2e-13 Identities = 45/137 (32%), Positives = 74/137 (54%), Gaps = 3/137 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPELLN 426 +N +H DL++ N+LV+ +CK+ D GL++V + G + + W APE +N Sbjct: 374 RNYIHRDLRAANILVSAS----LVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 429 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 S + K DV+SFGI++ E++T G PY + +I + P PE+C + Sbjct: 430 FGSFTI--KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPR-PENCPEELY 486 Query: 248 SLMEQCWSAEPTERPSF 198 ++M +CW P ERP+F Sbjct: 487 NIMMRCWKNRPEERPTF 503
>EPHA4_MOUSE (Q03137) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (MPK-3) Length = 986 Score = 75.1 bits (183), Expect = 2e-13 Identities = 50/150 (33%), Positives = 74/150 (49%), Gaps = 5/150 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 VH DL + N+LVN +CKV D G+S+V + G + + W APE + Sbjct: 743 VHRDLAARNILVN----SNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-- 796 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + + DV+S+GIVMWE+++ GE PY D+ +I I P P C Sbjct: 797 AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP-PPMDCPIALHQ 855 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW E ++RP F ++V L + +P Sbjct: 856 LMLDCWQKERSDRPKFGQIVNMLDKLIRNP 885
>EPHA4_HUMAN (P54764) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8) Length = 986 Score = 75.1 bits (183), Expect = 2e-13 Identities = 50/150 (33%), Positives = 74/150 (49%), Gaps = 5/150 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 VH DL + N+LVN +CKV D G+S+V + G + + W APE + Sbjct: 743 VHRDLAARNILVN----SNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-- 796 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + + DV+S+GIVMWE+++ GE PY D+ +I I P P C Sbjct: 797 AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP-PPMDCPIALHQ 855 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW E ++RP F ++V L + +P Sbjct: 856 LMLDCWQKERSDRPKFGQIVNMLDKLIRNP 885
>EPHA4_CHICK (Q07496) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK8) Length = 986 Score = 75.1 bits (183), Expect = 2e-13 Identities = 50/150 (33%), Positives = 74/150 (49%), Gaps = 5/150 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 VH DL + N+LVN +CKV D G+S+V + G + + W APE + Sbjct: 743 VHRDLAARNILVN----SNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-- 796 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + + DV+S+GIVMWE+++ GE PY D+ +I I P P C Sbjct: 797 AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP-PPMDCPIALHQ 855 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW E ++RP F ++V L + +P Sbjct: 856 LMLDCWQKERSDRPKFGQIVNMLDKLIRNP 885
>EPA4A_XENLA (Q91845) Ephrin type-A receptor 4-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK-1) (xSEK-1) Length = 986 Score = 75.1 bits (183), Expect = 2e-13 Identities = 50/150 (33%), Positives = 74/150 (49%), Gaps = 5/150 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 VH DL + N+LVN +CKV D G+S+V + G + + W APE + Sbjct: 742 VHRDLAARNILVN----SNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-- 795 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + + DV+S+GIVMWE+++ GE PY D+ +I I P P C Sbjct: 796 AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP-PPMDCPIALHQ 854 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW E ++RP F ++V L + +P Sbjct: 855 LMLDCWQKERSDRPKFGQIVSMLDKLIRNP 884
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 75.1 bits (183), Expect = 2e-13 Identities = 54/154 (35%), Positives = 80/154 (51%), Gaps = 5/154 (3%) Frame = -1 Query: 602 GKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRGTLP--WMAPEL 432 G + VH DL + N LV Q + K+GD G+S+ + G R LP WM PE Sbjct: 643 GLHFVHRDLATRNCLVG----QGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPES 698 Query: 431 LNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLV-PESCDP 258 + + + DV+SFG+V+WE+ T G++P+ L I I R L P +C P Sbjct: 699 I--LYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQG--RELERPRACPP 754 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 + ++M CW EP +R S +V RL+A+A +P Sbjct: 755 EVYAIMRGCWQREPQQRHSIKDVHARLQALAQAP 788
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 75.1 bits (183), Expect = 2e-13 Identities = 46/140 (32%), Positives = 71/140 (50%), Gaps = 3/140 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG--GVRGTLPWMAPELLN 426 KN +H DL + N LV + + KV D GLS++ + G + + W APE L Sbjct: 306 KNFIHRDLAARNCLVG----ENHLVKVADFGLSRLMTGDTYTAHAGTKFPIKWTAPESL- 360 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + N S K DV++FG+++WE+ T G PY + + ++ R PE C + Sbjct: 361 -AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE-LLEKDYRMERPEGCPEKVY 418 Query: 248 SLMEQCWSAEPTERPSFTEV 189 LM CW P++RP+F E+ Sbjct: 419 ELMRACWQWNPSDRPAFAEI 438
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 75.1 bits (183), Expect = 2e-13 Identities = 49/153 (32%), Positives = 76/153 (49%), Gaps = 5/153 (3%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELL 429 N VH DL + N+LVN + +CKV D GLS+V + G + + W APE + Sbjct: 746 NYVHRDLAARNILVN----RNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI 801 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + DV+S+GIVMWE+++ GE PY ++ +I + P P C Sbjct: 802 --TYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQDVIKAVDEGYRLP-APMDCPVVL 858 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 LM CW ++RP F ++V L + +P+ Sbjct: 859 HQLMLDCWEKNRSDRPKFGQIVNTLDRLIRNPS 891
>ZAP70_MOUSE (P43404) Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa| zeta-associated protein) (Syk-related tyrosine kinase) Length = 618 Score = 75.1 bits (183), Expect = 2e-13 Identities = 55/155 (35%), Positives = 75/155 (48%), Gaps = 7/155 (4%) Frame = -1 Query: 599 KNIVHFDLKSDN-LLVNLRDPQRPICKVGDLGLSKV-----KCQTLISGGVRGTLPWMAP 438 KN VH DL + N LLVN R K+ D GLSK T S G + L W AP Sbjct: 454 KNFVHRDLAARNVLLVN-----RHYAKISDFGLSKALGADDSYYTARSAG-KWPLKWYAP 507 Query: 437 ELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCD 261 E +N S + DV+S+G+ MWE + G++PY + G + + R P C Sbjct: 508 ECINFRK--FSSRSDVWSYGVTMWEAFSYGQKPYKKMK-GPQVLDFIKQGKRMECPPECP 564 Query: 260 PQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 P+ +LM CW + +RP F V +R+R SP Sbjct: 565 PEMYALMSDCWIYKWEDRPDFLTVEQRMRNYYYSP 599
>INSRR_CAVPO (P14617) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1300 Score = 75.1 bits (183), Expect = 2e-13 Identities = 51/165 (30%), Positives = 84/165 (50%), Gaps = 10/165 (6%) Frame = -1 Query: 638 GWMLHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-L 480 G M+ + I G VH DL + N +V+ Q K+GD G+++ +T Sbjct: 1090 GDMIQMAGEIADGMAYLAANKFVHRDLAARNCMVS----QDFTVKIGDFGMTRDVYETDY 1145 Query: 479 ISGGVRGTLP--WMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIG 309 G +G LP WMAPE L + + DV+SFG+V+WE++T E+PY L ++ Sbjct: 1146 YRKGGKGLLPVRWMAPESLK--DGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLK 1203 Query: 308 GIVNNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLR 174 +++ + + E C Q + LM CW P RP+FT+++ ++ Sbjct: 1204 FVMDGGVLEEL-EDCPHQLQELMSSCWQQNPRLRPTFTQILNSIQ 1247
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 75.1 bits (183), Expect = 2e-13 Identities = 53/166 (31%), Positives = 83/166 (50%), Gaps = 9/166 (5%) Frame = -1 Query: 632 MLHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLIS 474 +L + W + G +N +H DL + N+LV + +CKVGD GL++ +K +S Sbjct: 289 LLDIAWQVAEGMCYLESQNYIHRDLAARNILVG----ENTLCKVGDFGLARLIKEDVYLS 344 Query: 473 GGVRGTLPWMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADL-HYGAIIGGIV 300 W APE L S S K DV+SFGI++ E+ + G+ PY + ++ A + V Sbjct: 345 HDHNIPYKWTAPEAL--SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLR--V 400 Query: 299 NNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMAT 162 + R P C P LM CW +P +RP F + +RL + + Sbjct: 401 DAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTS 446
>INSRR_MOUSE (Q9WTL4) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1300 Score = 74.7 bits (182), Expect = 2e-13 Identities = 48/146 (32%), Positives = 79/146 (54%), Gaps = 4/146 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMAPELL 429 K VH DL + N +V+ Q K+GD G+++ +T G +G LP WMAPE L Sbjct: 1109 KKFVHRDLAARNCMVS----QDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESL 1164 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + DV+SFG+V+WE++T E+PY L ++ +++ + + E+C Q Sbjct: 1165 K--DGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEEL-ENCPIQL 1221 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLR 174 + LM CW P RP+F ++ R++ Sbjct: 1222 QELMRLCWQHSPRLRPTFVHILDRIQ 1247
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 74.7 bits (182), Expect = 2e-13 Identities = 53/164 (32%), Positives = 82/164 (50%), Gaps = 9/164 (5%) Frame = -1 Query: 632 MLHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG 471 +LH ++ G K +H DL + N+LV + I K+ D GLS+ Q + Sbjct: 939 LLHFAADVARGMDYLSQKQFIHRDLAARNILVG----ENYIAKIADFGLSRG--QEVYVK 992 Query: 470 GVRGTLP--WMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIV 300 G LP WMA E LN S + + DV+S+G+++WE+++ G PY + + + Sbjct: 993 KTMGRLPVRWMAIESLNYS--VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP 1050 Query: 299 NNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAM 168 R P +CD + LM QCW +P ERPSF +++ L M Sbjct: 1051 QG-YRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRM 1093
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 74.7 bits (182), Expect = 2e-13 Identities = 45/137 (32%), Positives = 74/137 (54%), Gaps = 3/137 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPELLN 426 KN +H DL++ N+LV+ + CK+ D GL+++ + G + + W APE +N Sbjct: 356 KNYIHRDLRAANILVS----EALCCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 411 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + + K DV+SFGI++ E++T G PY + +I + P P++C + Sbjct: 412 YGTFTI--KSDVWSFGILLTEIVTYGRIPYPGMTNPEVIQNLERGYRMPQ-PDNCPQELY 468 Query: 248 SLMEQCWSAEPTERPSF 198 LM QCW +P ERP+F Sbjct: 469 ELMMQCWKEQPEERPTF 485
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 74.7 bits (182), Expect = 2e-13 Identities = 55/172 (31%), Positives = 91/172 (52%), Gaps = 9/172 (5%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVR---GTLPWMAPELL 429 KNI+H D+KS+N+ ++ + K+GD GL+ VK + S V G++ WMAPE++ Sbjct: 462 KNIIHRDMKSNNIFLH----EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVI 517 Query: 428 N-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAII-----GGIVNNTLRPLVPES 267 SN S + DV+S+GIV++EL+TGE PY+ ++ I G + L L ++ Sbjct: 518 RMQDSNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLY-KN 576 Query: 266 CDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQK*TALSSLH 111 C + L+ C ERP F +++ + + S P + + + SLH Sbjct: 577 CPKAMKRLVADCLKKVREERPLFPQILSSIELLQHS--LPKINRSASEPSLH 626
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 74.7 bits (182), Expect = 2e-13 Identities = 44/137 (32%), Positives = 75/137 (54%), Gaps = 3/137 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPELLN 426 +N +H DL++ N+LV+ +CK+ D GL+++ + G + + W APE +N Sbjct: 351 RNYIHRDLRAANILVSAS----LVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAIN 406 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 S + K DV+SFGI++ E++T G PY + +I + + P P++C + Sbjct: 407 FGSFTI--KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPR-PDNCPEELY 463 Query: 248 SLMEQCWSAEPTERPSF 198 S+M +CW P ERP+F Sbjct: 464 SIMIRCWKNRPEERPTF 480
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 74.7 bits (182), Expect = 2e-13 Identities = 51/149 (34%), Positives = 75/149 (50%), Gaps = 11/149 (7%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLI---SGGVRGTLPWMAPELLNG 423 ++H DLK N+L DP+ + K+ D GLS + + SG GTL ++APEL Sbjct: 138 LLHRDLKPSNVLP---DPELHV-KLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVN 193 Query: 422 SSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPE--SCDPQ-- 255 + S DV+SFGI+MW +L G E + + N RP + E P+ Sbjct: 194 VNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETP 253 Query: 254 ----WRSLMEQCWSAEPTERPSFTEVVKR 180 + LM+ CWS+EP +RPSF E + + Sbjct: 254 GLEGLKELMQLCWSSEPKDRPSFQECLPK 282
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 74.7 bits (182), Expect = 2e-13 Identities = 46/158 (29%), Positives = 82/158 (51%), Gaps = 11/158 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK----VKCQTLISGGVRGTLPWMAPEL 432 ++I+H DLK N+L++ +D +CK+ D G S+ ++C+ + GT APE+ Sbjct: 223 QSILHLDLKPANILISEQD----VCKISDFGCSQKLQDLRCRQASPHHIGGTYTHQAPEI 278 Query: 431 LNGSSNLVSEKVDVFSFGIVMWELLTGEEPYA-DLHYGAIIGGIVNNTLRP------LVP 273 L G + + K D++SFGI +W++ T E PY+ + Y + +V LRP Sbjct: 279 LKGE--IATPKADIYSFGITLWQMTTREVPYSGEPQY--VQYAVVAYNLRPSLAGAVFTA 334 Query: 272 ESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATS 159 +++++ CW A +RP + + L+A+A S Sbjct: 335 SLTGKTLQNIIQSCWEARALQRPGAELLQRDLKALADS 372
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 74.7 bits (182), Expect = 2e-13 Identities = 51/154 (33%), Positives = 72/154 (46%), Gaps = 7/154 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + G +P W A E Sbjct: 740 NYVHRDLAARNILVN----SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAQE 795 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + + DV+S+GIVMWE+++ GE PY + +I I + P P C Sbjct: 796 AI--AYRKFTSASDVWSYGIVMWEVMSYGERPYWTMSNQDVINAIEQDYRLP-PPMDCPA 852 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP E+V LR M +P Sbjct: 853 ALHQLMLDCWQKDRNSRPRLAEIVNTLRPMIRNP 886
>FES_HUMAN (P07332) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2)| (C-Fes) Length = 822 Score = 74.7 bits (182), Expect = 2e-13 Identities = 51/148 (34%), Positives = 77/148 (52%), Gaps = 4/148 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLI--SGGVRGT-LPWMAPELL 429 K +H DL + N LV ++ + K+ D G+S+ + + SGG R + W APE L Sbjct: 677 KCCIHRDLAARNCLVT----EKNVLKISDFGMSREEADGVYAASGGSRQVPVKWTAPEAL 732 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 N S + DV+SFGI++WE + G PY +L + P PE C Sbjct: 733 NYGR--YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC-PELCPDAV 789 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAM 168 LMEQCW+ EP +RPSF+ + + L+++ Sbjct: 790 FRLMEQCWAYEPGQRPSFSTIYQELQSI 817
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 74.7 bits (182), Expect = 2e-13 Identities = 51/152 (33%), Positives = 74/152 (48%), Gaps = 7/152 (4%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT------LISGGVRGTLPWMAPELL 429 VH DL + N+LVN +CKV D GLS+ + S G + ++ W APE + Sbjct: 737 VHRDLAARNILVN----SNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKISIRWTAPEAI 792 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + D +S+GIVMWE+++ GE PY D+ +I I + P P+ C Sbjct: 793 --AFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPD-CPTSL 849 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP F +VV L M +P Sbjct: 850 HQLMLDCWQKDRNARPRFPQVVSALDKMIRNP 881
>EPHB3_CHICK (Q07498) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor CEK10) (Fragment) Length = 988 Score = 74.3 bits (181), Expect = 3e-13 Identities = 49/147 (33%), Positives = 71/147 (48%), Gaps = 7/147 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + G +P W APE Sbjct: 743 NYVHRDLAARNILVN----SNLVCKVSDFGLSRFLEDDPADPTYTSSLGGKIPIRWTAPE 798 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + + DV+S+GIVMWE+++ GE PY D+ +I + + P P C Sbjct: 799 AI--AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLP-PPMDCPT 855 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRL 177 LM CW + RP F ++V L Sbjct: 856 ALHQLMLDCWVRDRNLRPKFAQIVNTL 882
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 74.3 bits (181), Expect = 3e-13 Identities = 52/164 (31%), Positives = 82/164 (50%), Gaps = 9/164 (5%) Frame = -1 Query: 632 MLHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG 471 +LH ++ G K +H DL + N+LV + + K+ D GLS+ Q + Sbjct: 941 LLHFAADVARGMDYLSQKQFIHRDLAARNILVG----ENYVAKIADFGLSRG--QEVYVK 994 Query: 470 GVRGTLP--WMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIV 300 G LP WMA E LN S + + DV+S+G+++WE+++ G PY + + + Sbjct: 995 KTMGRLPVRWMAIESLNYS--VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP 1052 Query: 299 NNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAM 168 R P +CD + LM QCW +P ERPSF +++ L M Sbjct: 1053 QG-YRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRM 1095
>KIT_FSVHZ (P04048) Tyrosine-protein kinase transforming protein kit (EC| 2.7.10.1) Length = 370 Score = 74.3 bits (181), Expect = 3e-13 Identities = 44/143 (30%), Positives = 74/143 (51%), Gaps = 4/143 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLS---KVKCQTLISGGVRGTLPWMAPELL 429 KN +H DL + N+L+ I K+ D GL+ K ++ G R + WMAPE + Sbjct: 224 KNCIHRDLAARNILLT----HGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESI 279 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+S+GI +WEL + G PY + + ++ R L PE + Sbjct: 280 FNC--VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEM 337 Query: 251 RSLMEQCWSAEPTERPSFTEVVK 183 +M+ CW A+P +RP+F ++V+ Sbjct: 338 YDIMKTCWDADPLKRPTFKQIVQ 360
>EPHB3_HUMAN (P54753) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HEK-2) Length = 998 Score = 74.3 bits (181), Expect = 3e-13 Identities = 49/147 (33%), Positives = 72/147 (48%), Gaps = 7/147 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + G +P W APE Sbjct: 753 NYVHRDLAARNILVN----SNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPE 808 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + + DV+S+GIVMWE+++ GE PY D+ +I + + P P C Sbjct: 809 AI--AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLP-PPMDCPT 865 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRL 177 LM CW + RP F+++V L Sbjct: 866 ALHQLMLDCWVRDRNLRPKFSQIVNTL 892
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 74.3 bits (181), Expect = 3e-13 Identities = 52/164 (31%), Positives = 82/164 (50%), Gaps = 9/164 (5%) Frame = -1 Query: 632 MLHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG 471 +LH ++ G K +H DL + N+LV + + K+ D GLS+ Q + Sbjct: 942 LLHFAADVARGMDYLSQKQFIHRDLAARNILVG----ENYVAKIADFGLSRG--QEVYVK 995 Query: 470 GVRGTLP--WMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIV 300 G LP WMA E LN S + + DV+S+G+++WE+++ G PY + + + Sbjct: 996 KTMGRLPVRWMAIESLNYS--VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP 1053 Query: 299 NNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAM 168 R P +CD + LM QCW +P ERPSF +++ L M Sbjct: 1054 QG-YRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRM 1096
>EPHB3_MOUSE (P54754) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4) Length = 993 Score = 74.3 bits (181), Expect = 3e-13 Identities = 49/147 (33%), Positives = 72/147 (48%), Gaps = 7/147 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + G +P W APE Sbjct: 748 NYVHRDLAARNILVN----SNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPE 803 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + + DV+S+GIVMWE+++ GE PY D+ +I + + P P C Sbjct: 804 AI--AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLP-PPMDCPT 860 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRL 177 LM CW + RP F+++V L Sbjct: 861 ALHQLMLDCWVRDRNLRPKFSQIVNTL 887
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 74.3 bits (181), Expect = 3e-13 Identities = 49/137 (35%), Positives = 70/137 (51%), Gaps = 4/137 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G + + W APE L Sbjct: 380 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 435 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + G ++ + P PE C Sbjct: 436 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPPE-CPESLH 491 Query: 248 SLMEQCWSAEPTERPSF 198 LM QCW +P ERP+F Sbjct: 492 DLMSQCWRRDPEERPTF 508
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 73.9 bits (180), Expect = 4e-13 Identities = 48/147 (32%), Positives = 73/147 (49%), Gaps = 10/147 (6%) Frame = -1 Query: 608 CTGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVK----CQTLISGGVRGTLPWMA 441 C ++H DLK N+L++ K+ D GL+K L G+ GT+ ++ Sbjct: 134 CMAPPLLHLDLKPANILLDAHYH----VKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLP 189 Query: 440 PELLNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLVPESCD 261 PE + S L K DV+SF IV+W +LT ++P+AD I V RP +P C Sbjct: 190 PERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCR 249 Query: 260 PQWRS------LMEQCWSAEPTERPSF 198 + R+ LM++CW +P RP+F Sbjct: 250 ARPRACSHLIRLMQRCWQGDPRVRPTF 276
>EPA4B_XENLA (Q91694) Ephrin type-A receptor 4-B precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor PAG) (Pagliaccio) Length = 985 Score = 73.9 bits (180), Expect = 4e-13 Identities = 49/150 (32%), Positives = 74/150 (49%), Gaps = 5/150 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 VH DL + N+LVN +CKV D G+S+V + G + + W APE + Sbjct: 742 VHRDLAARNILVN----SNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-- 795 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + + DV+S+GIVMWE+++ GE PY D+ +I I P P C Sbjct: 796 AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP-PPMDCPIALHQ 854 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + ++RP F ++V L + +P Sbjct: 855 LMLDCWQKDRSDRPKFGQIVSMLDKLIRNP 884
>EGL15_CAEEL (Q10656) Myoblast growth factor receptor egl-15 precursor (EC| 2.7.10.1) (Egg-laying defective protein 15) Length = 1040 Score = 73.9 bits (180), Expect = 4e-13 Identities = 53/162 (32%), Positives = 77/162 (47%), Gaps = 4/162 (2%) Frame = -1 Query: 635 WMLHLVWNICTGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRG 459 W + N K I+H DL + N+LV + K+ D GLS+ V C G Sbjct: 779 WQVAQGMNFLASKKIIHRDLAARNVLVG----DGHVLKISDFGLSRDVHCNDYYRKRGNG 834 Query: 458 TLP--WMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTL 288 LP WMA E L+ SN+ + + DV+S+G+++WE++T G PY + + + Sbjct: 835 RLPIKWMALEALD--SNVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEG-Y 891 Query: 287 RPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMAT 162 R P C + LM CW + ERPSF +V L M T Sbjct: 892 RMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLDWMLT 933
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 73.6 bits (179), Expect = 5e-13 Identities = 51/148 (34%), Positives = 77/148 (52%), Gaps = 4/148 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLI--SGGVRGT-LPWMAPELL 429 K +H DL + N LV ++ + K+ D G+S+ + + SGG+R + W APE L Sbjct: 332 KCCIHRDLAARNCLVT----EKNVLKISDFGMSREEADGVYAASGGLRLVPVKWTAPEAL 387 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 N S + DV+SFGI++WE + G PY +L + P PE C Sbjct: 388 NYGR--YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC-PELCPDAV 444 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAM 168 LMEQCW+ EP +RPSF+ + L+++ Sbjct: 445 FRLMEQCWAYEPGQRPSFSAFYQELQSI 472
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 73.6 bits (179), Expect = 5e-13 Identities = 43/137 (31%), Positives = 75/137 (54%), Gaps = 3/137 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPELLN 426 +N +H DL++ N+LV+ +CK+ D GL+++ + G + + W APE +N Sbjct: 372 RNYIHRDLRAANILVSAS----LVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAIN 427 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 S + K DV+SFGI++ E++T G PY + +I + + P P++C + Sbjct: 428 FGSFTI--KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPR-PDNCPEELY 484 Query: 248 SLMEQCWSAEPTERPSF 198 ++M +CW P ERP+F Sbjct: 485 NIMIRCWKNRPEERPTF 501
>EPHB3_BRARE (O13147) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK3) (EPH-like kinase 3) (Fragment) Length = 500 Score = 73.6 bits (179), Expect = 5e-13 Identities = 49/147 (33%), Positives = 72/147 (48%), Gaps = 7/147 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLP--WMAPE 435 N VH DL + N+LVN +CKV D GLS+ + + G +P W APE Sbjct: 307 NYVHRDLAARNVLVN----SNLVCKVSDFGLSRFLDDNSSDPTYTSSLGGKIPIRWTAPE 362 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + + DV+S+GIVMWE+++ GE PY D+ ++ + + P P C Sbjct: 363 AI--AFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVMNAVEQDYRLP-PPMDCPA 419 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRL 177 LM +CW E RP F ++V L Sbjct: 420 VLHQLMLECWVKERNMRPRFGQIVSTL 446
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 73.6 bits (179), Expect = 5e-13 Identities = 52/148 (35%), Positives = 77/148 (52%), Gaps = 13/148 (8%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVK--CQTLISGGVR---GTLPWMAPEL 432 +++H DLK N+L++L K+ D GLS + Q+ G R GTL ++APEL Sbjct: 138 SLLHRDLKPSNVLLDLELH----AKLADFGLSTFQGGSQSGSGSGSRDSGGTLAYLAPEL 193 Query: 431 LNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRP----LVPESC 264 L+ S+ DV+SFG+++W +L G E I G + N RP L P+S Sbjct: 194 LDNDGK-ASKASDVYSFGVLVWTVLAGREAEVVDKTSLIRGAVCNRQRRPPLTELPPDSP 252 Query: 263 DPQ----WRSLMEQCWSAEPTERPSFTE 192 + + LM CWS+EP +RPSF + Sbjct: 253 ETPGLEGLKELMTHCWSSEPKDRPSFQD 280
>FAK2_RAT (P70600) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal| adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) Length = 1009 Score = 73.6 bits (179), Expect = 5e-13 Identities = 50/141 (35%), Positives = 76/141 (53%), Gaps = 4/141 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPIC-KVGDLGLSK-VKCQTLISGGV-RGTLPWMAPELLN 426 N VH D+ N+LV P C K+GD GLS+ ++ + V R + WM+PE +N Sbjct: 544 NCVHRDIAVRNILV-----ASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESIN 598 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + DV+ F + MWE+L+ G++P+ L +IG + P PE C P Sbjct: 599 FRRFTTAS--DVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPK-PELCPPVLY 655 Query: 248 SLMEQCWSAEPTERPSFTEVV 186 +LM +CW +P++RP FTE+V Sbjct: 656 TLMTRCWDYDPSDRPRFTELV 676
>FAK2_MOUSE (Q9QVP9) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal| adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinas Length = 1009 Score = 73.6 bits (179), Expect = 5e-13 Identities = 50/141 (35%), Positives = 76/141 (53%), Gaps = 4/141 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPIC-KVGDLGLSK-VKCQTLISGGV-RGTLPWMAPELLN 426 N VH D+ N+LV P C K+GD GLS+ ++ + V R + WM+PE +N Sbjct: 544 NCVHRDIAVRNILV-----ASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESIN 598 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + DV+ F + MWE+L+ G++P+ L +IG + P PE C P Sbjct: 599 FRRFTTAS--DVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPK-PELCPPVLY 655 Query: 248 SLMEQCWSAEPTERPSFTEVV 186 +LM +CW +P++RP FTE+V Sbjct: 656 TLMTRCWDYDPSDRPRFTELV 676
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 73.6 bits (179), Expect = 5e-13 Identities = 49/151 (32%), Positives = 73/151 (48%), Gaps = 5/151 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 VH DL + N+L+N +CKV D GLS+V + G + + W APE + Sbjct: 797 VHRDLAARNILIN----SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-- 850 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + + DV+S+GIVMWE+++ GE PY ++ +I + P P C Sbjct: 851 AFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPS-PMDCPAALYQ 909 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 LM CW E RP F E+V L + +P+ Sbjct: 910 LMLDCWQKERNSRPKFDEIVNMLDKLIRNPS 940
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 73.2 bits (178), Expect = 6e-13 Identities = 52/166 (31%), Positives = 81/166 (48%), Gaps = 7/166 (4%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 VH DL + N+L+N +CKV D GLS+V + G + + W APE + Sbjct: 773 VHRDLAARNILIN----SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-- 826 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + + DV+S+GIVMWE+++ GE PY ++ +I + P P C Sbjct: 827 AFRKFTSASDVWSYGIVMWEVMSYGERPYWEMTNQDVIKAVEEGYRLPS-PMDCPAALYQ 885 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSPT--KPLLQK*TALSSL 114 LM CW + RP F E+V L + +P+ K L+ + +S+L Sbjct: 886 LMLDCWQKDRNSRPKFDEIVSMLDKLIRNPSSLKTLVNASSRVSNL 931
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 73.2 bits (178), Expect = 6e-13 Identities = 54/152 (35%), Positives = 78/152 (51%), Gaps = 5/152 (3%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRGTLP--WMAPELLN 426 + VH DL + N LV Q + K+GD G+S+ + G R LP WM PE + Sbjct: 648 HFVHRDLATRNCLVG----QGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESI- 702 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLV-PESCDPQW 252 S + DV+SFG+V+WE+ T G++P+ L I I R L P +C P Sbjct: 703 -LYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQG--RELERPRACPPDV 759 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 ++M CW EP +R S +V RL+A+A +P Sbjct: 760 YAIMRGCWQREPQQRLSMKDVHARLQALAQAP 791
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 73.2 bits (178), Expect = 6e-13 Identities = 48/148 (32%), Positives = 75/148 (50%), Gaps = 1/148 (0%) Frame = -1 Query: 602 GKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNG 423 G N VH DL + N+LV+ + + KV D GL+K T +G + + W APE L Sbjct: 307 GNNFVHRDLAARNVLVS----EDNVAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALRE 360 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 S K DV+SFGI++WE+ + G PY + ++ V + P+ C P Sbjct: 361 KK--FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR-VEKGYKMDAPDGCPPAVYE 417 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMAT 162 +M+ CW + RPSF ++ ++L + T Sbjct: 418 VMKNCWHLDAAMRPSFLQLREQLEHIKT 445
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 73.2 bits (178), Expect = 6e-13 Identities = 50/137 (36%), Positives = 70/137 (51%), Gaps = 4/137 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G R + W APE L Sbjct: 377 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARPGARFPVKWTAPEAALY 432 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + G ++ + P PE C Sbjct: 433 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMVNGEVLDRVERGYRMPCPPE-CPESLH 488 Query: 248 SLMEQCWSAEPTERPSF 198 LM QCW +P ERP+F Sbjct: 489 DLMCQCWRKDPEERPTF 505
>TIE1_BRARE (O73792) Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1)| (Fragment) Length = 184 Score = 73.2 bits (178), Expect = 6e-13 Identities = 52/164 (31%), Positives = 81/164 (49%), Gaps = 9/164 (5%) Frame = -1 Query: 632 MLHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG 471 +L ++ TG K +H DL + N+LV + K+ D GLS+ + + Sbjct: 2 LLQFAADVATGMHYLSDKQFIHRDLAARNVLVG----DNLVAKIADFGLSRG--EEVYVK 55 Query: 470 GVRGTLP--WMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIV 300 G LP WMA E LN S + + K DV+SFG+++WE+++ G PY + + + Sbjct: 56 KTMGRLPVRWMAIESLNYS--VYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP 113 Query: 299 NNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAM 168 R P +CD + LM QCW P ERP F+++ +L M Sbjct: 114 QG-YRMEQPRNCDDEVYELMRQCWRDRPYERPPFSQISVQLNRM 156
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 73.2 bits (178), Expect = 6e-13 Identities = 54/172 (31%), Positives = 91/172 (52%), Gaps = 9/172 (5%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVR---GTLPWMAPELL 429 KNI+H D+KS+N+ ++ + K+GD GL+ VK + S V G++ WMAPE++ Sbjct: 462 KNIIHRDMKSNNIFLH----EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVI 517 Query: 428 N-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAII-----GGIVNNTLRPLVPES 267 +N S + DV+S+GIV++EL+TGE PY+ ++ I G + L L ++ Sbjct: 518 RMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLY-KN 576 Query: 266 CDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQK*TALSSLH 111 C + L+ C ERP F +++ + + S P + + + SLH Sbjct: 577 CPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS--LPKINRSASEPSLH 626
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 72.8 bits (177), Expect = 8e-13 Identities = 54/172 (31%), Positives = 91/172 (52%), Gaps = 9/172 (5%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVR---GTLPWMAPELL 429 KNI+H D+KS+N+ ++ + K+GD GL+ VK + S V G++ WMAPE++ Sbjct: 462 KNIIHRDMKSNNIFLH----EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVI 517 Query: 428 N-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAII-----GGIVNNTLRPLVPES 267 +N S + DV+S+GIV++EL+TGE PY+ ++ I G + L L ++ Sbjct: 518 RMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLY-KN 576 Query: 266 CDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQK*TALSSLH 111 C + L+ C ERP F +++ + + S P + + + SLH Sbjct: 577 CPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS--LPKINRSASEPSLH 626
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/137 (35%), Positives = 70/137 (51%), Gaps = 4/137 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G + + W APE L Sbjct: 380 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 435 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + G ++ + P PE C Sbjct: 436 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPPE-CPESLH 491 Query: 248 SLMEQCWSAEPTERPSF 198 LM QCW +P ERP+F Sbjct: 492 DLMCQCWRRDPEERPTF 508
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 72.8 bits (177), Expect = 8e-13 Identities = 49/137 (35%), Positives = 70/137 (51%), Gaps = 4/137 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G + + W APE L Sbjct: 380 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 435 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + G ++ + P PE C Sbjct: 436 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPPE-CPESLH 491 Query: 248 SLMEQCWSAEPTERPSF 198 LM QCW +P ERP+F Sbjct: 492 DLMCQCWRRDPEERPTF 508
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 72.8 bits (177), Expect = 8e-13 Identities = 55/172 (31%), Positives = 90/172 (52%), Gaps = 9/172 (5%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVR---GTLPWMAPELL 429 KNI+H D+KS+N+ ++ K+GD GL+ VK + S V G++ WMAPE++ Sbjct: 195 KNIIHRDMKSNNIFLH----GGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVI 250 Query: 428 N-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAII-----GGIVNNTLRPLVPES 267 SN S + DV+S+GIV++EL+TGE PY+ ++ I G + L L ++ Sbjct: 251 RMQDSNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLY-KN 309 Query: 266 CDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQK*TALSSLH 111 C + L+ C ERP F +++ + + S P + + + SLH Sbjct: 310 CPKAMKRLVADCLKKVREERPLFPQILSSIALLQHS--LPKINRSASEPSLH 359
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 72.8 bits (177), Expect = 8e-13 Identities = 52/166 (31%), Positives = 81/166 (48%), Gaps = 7/166 (4%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 VH DL + N+L+N +CKV D GLS+V + G + + W APE + Sbjct: 636 VHRDLAARNILIN----SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-- 689 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + + DV+S+GIVMWE+++ GE PY ++ +I + P P C Sbjct: 690 AFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPS-PMDCPAALYQ 748 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSPT--KPLLQK*TALSSL 114 LM CW + RP F E+V L + +P+ K L+ + +S+L Sbjct: 749 LMLDCWQKDRNSRPKFDEIVNMLDKLIRNPSSLKTLVNASSRVSTL 794
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 72.8 bits (177), Expect = 8e-13 Identities = 47/146 (32%), Positives = 76/146 (52%), Gaps = 2/146 (1%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGT-LPWMAPELLNG 423 KN +H DL + N LV+L K+ D G+S+ + + ++S G++ + W APE LN Sbjct: 1179 KNCIHRDLAARNCLVDLEHS----VKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNF 1234 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + DV+S+GI+MWE+ + G+ PY+ + I P P+S + Sbjct: 1235 GK--YTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMP-TPKSTPEEMYR 1291 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAM 168 LM QCW+A+ RP F E+ + A+ Sbjct: 1292 LMLQCWAADAESRPHFDEIYNVVDAL 1317
>VGFR1_HUMAN (P17948) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1) Length = 1338 Score = 72.8 bits (177), Expect = 8e-13 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 4/147 (2%) Frame = -1 Query: 605 TGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT---LISGGVRGTLPWMAPE 435 + + +H DL + N+L++ + + K+ D GL++ + + G R L WMAPE Sbjct: 1014 SSRKCIHRDLAARNILLS----ENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPE 1069 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + S K DV+S+G+++WE+ + G PY + + +R PE P Sbjct: 1070 SI--FDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTP 1127 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRL 177 + +M CW +P ERP F E+V++L Sbjct: 1128 EIYQIMLDCWHRDPKERPRFAELVEKL 1154
>7LESS_DROVI (P20806) Protein sevenless (EC 2.7.10.1)| Length = 2594 Score = 72.8 bits (177), Expect = 8e-13 Identities = 54/152 (35%), Positives = 80/152 (52%), Gaps = 7/152 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVN--LRDPQRPICKVGDLGLSK--VKCQTLISGGVRGTLP--WMAPE 435 + VH DL N LV+ R I K+GD GL++ K G G LP WMA E Sbjct: 2350 HFVHRDLACRNCLVSDGAAIGGRRIVKIGDFGLARDIYKSDYYRKEG-EGLLPVRWMALE 2408 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 L L S + DV++FG++ WE+ T G++PYA + ++ + R PE C Sbjct: 2409 SL--VDGLFSTQSDVWAFGVLCWEIFTLGQQPYAARNNFEVLAHVKEGG-RLQQPERCPE 2465 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMAT 162 + +L+ QCW +EP ERPSF + L+A+++ Sbjct: 2466 KLYALLLQCWRSEPWERPSFKRCLSTLQALSS 2497
>FAK2_HUMAN (Q14289) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal| adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinas Length = 1009 Score = 72.4 bits (176), Expect = 1e-12 Identities = 49/141 (34%), Positives = 76/141 (53%), Gaps = 4/141 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPIC-KVGDLGLSK-VKCQTLISGGV-RGTLPWMAPELLN 426 N VH D+ N+LV P C K+GD GLS+ ++ + V R + WM+PE +N Sbjct: 544 NCVHRDIAVRNILV-----ASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESIN 598 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + DV+ F + MWE+L+ G++P+ L +IG + P P+ C P Sbjct: 599 FRRFTTAS--DVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPK-PDLCPPVLY 655 Query: 248 SLMEQCWSAEPTERPSFTEVV 186 +LM +CW +P++RP FTE+V Sbjct: 656 TLMTRCWDYDPSDRPRFTELV 676
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 72.4 bits (176), Expect = 1e-12 Identities = 47/148 (31%), Positives = 75/148 (50%), Gaps = 1/148 (0%) Frame = -1 Query: 602 GKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNG 423 G N VH DL + N+LV+ + + KV D GL+K T +G + + W APE L Sbjct: 307 GNNFVHRDLAARNVLVS----EDNVAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALRE 360 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 S K DV+SFGI++WE+ + G PY + ++ V + P+ C P Sbjct: 361 KK--FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR-VEKGYKMDAPDGCPPAVYD 417 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMAT 162 +M+ CW + RP+F ++ ++L + T Sbjct: 418 VMKNCWHLDAATRPTFLQLREQLEHIRT 445
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 72.4 bits (176), Expect = 1e-12 Identities = 41/136 (30%), Positives = 76/136 (55%), Gaps = 3/136 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV-KCQTLISGGVRGTLPWMAPELLNGS 420 N +H DL++ N+LV+ + CK+ D GL+++ + G + + W APE ++ Sbjct: 354 NSIHRDLRAANILVS----EALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIH-- 407 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQ-WRS 246 + + K DV+SFG+++ E++T G PY + +I + P P++C P+ +R Sbjct: 408 FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPR-PDTCPPELYRG 466 Query: 245 LMEQCWSAEPTERPSF 198 ++ +CW + P ERP+F Sbjct: 467 VIAECWRSRPEERPTF 482
>INSR_DROME (P09208) Insulin-like receptor precursor (EC 2.7.10.1) (DIR) (DInr)| (dIRH) [Contains: Insulin-like receptor alpha subunit; Insulin-like receptor beta 1 subunit; Insulin-like receptor beta 2 subunit] Length = 2144 Score = 72.4 bits (176), Expect = 1e-12 Identities = 47/145 (32%), Positives = 73/145 (50%), Gaps = 4/145 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMAPELL 429 K VH DL + N +V K+GD G+++ +T G +G LP WM PE L Sbjct: 1513 KKFVHRDLAARNCMV----ADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESL 1568 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + S DVFSFG+V+WE+ T +PY L ++ +++ + PE+C Sbjct: 1569 R--DGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMER-PENCPDFL 1625 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRL 177 LM++CW + RPSF +++ L Sbjct: 1626 HKLMQRCWHHRSSARPSFLDIIAYL 1650
>VGFR1_MOUSE (P35969) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2) Length = 1333 Score = 72.4 bits (176), Expect = 1e-12 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 4/147 (2%) Frame = -1 Query: 605 TGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT---LISGGVRGTLPWMAPE 435 + + +H DL + N+L++ + + K+ D GL++ + + G R L WMAPE Sbjct: 1014 SSRKCIHRDLAARNILLS----ENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPE 1069 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + S K DV+S+G+++WE+ + G PY + + +R PE P Sbjct: 1070 SI--FDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATP 1127 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRL 177 + +M CW +P ERP F E+V++L Sbjct: 1128 EIYQIMLDCWHKDPKERPRFAELVEKL 1154
>VGFR3_RAT (Q91ZT1) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1363 Score = 72.4 bits (176), Expect = 1e-12 Identities = 44/145 (30%), Positives = 76/145 (52%), Gaps = 4/145 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT---LISGGVRGTLPWMAPELL 429 + +H DL + N+L++ D I K+ D GL++ + + G R L WMAPE + Sbjct: 1031 RKCIHRDLAARNILLSESD----IVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESI 1086 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+SFG+++WE+ + G PY + + + R PE P Sbjct: 1087 --FDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAI 1144 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRL 177 R +M+ CWS +P RP+F+++V+ L Sbjct: 1145 RHIMQSCWSGDPKARPAFSDLVEIL 1169
>VGFR3_MOUSE (P35917) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1363 Score = 72.4 bits (176), Expect = 1e-12 Identities = 44/145 (30%), Positives = 76/145 (52%), Gaps = 4/145 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT---LISGGVRGTLPWMAPELL 429 + +H DL + N+L++ D I K+ D GL++ + + G R L WMAPE + Sbjct: 1031 RKCIHRDLAARNILLSESD----IVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESI 1086 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+SFG+++WE+ + G PY + + + R PE P Sbjct: 1087 --FDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAI 1144 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRL 177 R +M+ CWS +P RP+F+++V+ L Sbjct: 1145 RHIMQSCWSGDPKARPAFSDLVEIL 1169
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 72.4 bits (176), Expect = 1e-12 Identities = 48/147 (32%), Positives = 77/147 (52%), Gaps = 3/147 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELLN 426 + +VH DL + N+LV+ CKV D GL+++ + S +P W APE N Sbjct: 344 QRVVHRDLAARNVLVD----DGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAAN 399 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + S+K DV+SFG+++ E+ T G+ PY + + I+ P P +C + Sbjct: 400 --YRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPR-PAACPAEVY 456 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAM 168 LM +CW + P ERPSF + ++L A+ Sbjct: 457 VLMLECWRSSPEERPSFATLREKLHAI 483
>ROR1_MOUSE (Q9Z139) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1) Length = 937 Score = 72.4 bits (176), Expect = 1e-12 Identities = 56/179 (31%), Positives = 84/179 (46%), Gaps = 15/179 (8%) Frame = -1 Query: 638 GWMLHLVWNICTGKN------IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTL 480 G LH+ I G VH DL + N+L+ ++ K+ DLGLS+ + Sbjct: 590 GDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIG----EQLHVKISDLGLSREIYSADY 645 Query: 479 ISGGVRGTLP--WMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIG 309 + +LP WM PE + S D++SFG+V+WE+ + G +PY +I Sbjct: 646 YRVQSKSSLPIRWMPPEAIMYGK--FSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIE 703 Query: 308 GIVNNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMA-----TSPTKP 147 + L P E C P+ SLM +CW+ P+ RP F ++ RLR+ TS T P Sbjct: 704 MVRKRQLLPC-SEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTP 761
>VGFR1_RAT (P53767) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) Length = 1336 Score = 72.4 bits (176), Expect = 1e-12 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 4/147 (2%) Frame = -1 Query: 605 TGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT---LISGGVRGTLPWMAPE 435 + + +H DL + N+L++ + + K+ D GL++ + + G R L WMAPE Sbjct: 1014 SSRKCIHRDLAARNILLS----ENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPE 1069 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 + + S K DV+S+G+++WE+ + G PY + + +R PE P Sbjct: 1070 SI--FDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATP 1127 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRL 177 + +M CW +P ERP F E+V++L Sbjct: 1128 EIYQIMLDCWHKDPKERPRFAELVEKL 1154
>TIE2_BRARE (O73791) Tyrosine-protein kinase receptor Tie-2 precursor (EC| 2.7.10.1) Length = 1116 Score = 72.0 bits (175), Expect = 1e-12 Identities = 52/152 (34%), Positives = 81/152 (53%), Gaps = 8/152 (5%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELLN 426 K +H DL + N+LV + + K+ D GLS+ Q + G LP WMA E LN Sbjct: 950 KQFIHRDLAARNVLVG----ENFVAKIADFGLSRG--QEVYVKKTMGRLPVRWMAIESLN 1003 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPY-----ADLHYGAIIGGIVNNTLRPLVPESC 264 S + + DV+S+G+++WE+++ G PY A+L+ +G R P +C Sbjct: 1004 YS--VYTTNSDVWSYGVLLWEVVSLGGTPYCGMTCAELYEKLPLG------FRLEKPLNC 1055 Query: 263 DPQWRSLMEQCWSAEPTERPSFTEVVKRLRAM 168 D + LM+QCW +P ERPSF++++ L M Sbjct: 1056 DDEVYELMQQCWREKPFERPSFSQILLSLGRM 1087
>LTK_HUMAN (P29376) Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1)| (Protein tyrosine kinase 1) Length = 864 Score = 72.0 bits (175), Expect = 1e-12 Identities = 49/169 (28%), Positives = 80/169 (47%), Gaps = 10/169 (5%) Frame = -1 Query: 632 MLHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLIS 474 +L L +I G + +H D+ + N L++ P R + K+GD G+++ + + Sbjct: 620 LLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSR-VAKIGDFGMARDIYRASYYR 678 Query: 473 GGVRGTLP--WMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGI 303 G R LP WM PE + + K D +SFG+++WE+ + G PY ++ + Sbjct: 679 RGDRALLPVKWMPPEAF--LEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFV 736 Query: 302 VNNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 V R P C +M QCW EP RPSF +++RL+ P Sbjct: 737 VGGG-RMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDP 784
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 72.0 bits (175), Expect = 1e-12 Identities = 52/157 (33%), Positives = 78/157 (49%), Gaps = 4/157 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N +H DL++ N+LV +CK+ D GL+++ + G + + W APE L Sbjct: 383 NYIHRDLRAANILVG----DNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALF 438 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL+T G PY ++ ++ V R P C P Sbjct: 439 GKFTI---KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQ-VERGYRMQCPGGCPPSLH 494 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQ 138 +M QCW EP ERP+F + L T+ T+P Q Sbjct: 495 DVMVQCWKREPEERPTFEYLQSFLEDYFTA-TEPQYQ 530
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 72.0 bits (175), Expect = 1e-12 Identities = 47/150 (31%), Positives = 76/150 (50%), Gaps = 3/150 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG--GVRGTLPWMAPELLN 426 +N +H DL + N+LV + ICKV D GL++V + + G + + W APE Sbjct: 353 QNYIHRDLAARNILVG----EHKICKVADFGLARVIDEEIYEAKLGAKFPIKWTAPEAAM 408 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 S + K DV+SFGIV++E++T G PY + ++ I + P P C + Sbjct: 409 YSRFTI--KSDVWSFGIVLYEVITYGRFPYPGMTNAQVLEQIQQSYRMPR-PMGCPEKLY 465 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATS 159 ++M CW +P RP+F + +L T+ Sbjct: 466 AIMMDCWREDPASRPTFETLSWQLEEFFTT 495
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 71.6 bits (174), Expect = 2e-12 Identities = 55/175 (31%), Positives = 91/175 (52%), Gaps = 12/175 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGV-----RGTLPWMAPE 435 KNI+H DLKS+N+ ++ + K+GD GL+ VK T SG G++ WMA E Sbjct: 423 KNIIHRDLKSNNIFLH----EGLTVKIGDFGLATVK--TRWSGAQPLEQPSGSVLWMAAE 476 Query: 434 LLNGSS-NLVSEKVDVFSFGIVMWELLTGEEPYADLHYGA---IIGGIVNNTLRP---LV 276 ++ N S + DV+++G+V++EL+TG PY+ H G+ II + L P + Sbjct: 477 VIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYS--HIGSRDQIIFMVGRGYLSPDLSKI 534 Query: 275 PESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQK*TALSSLH 111 +C R L+ C + ERP F +++ + + S P +++ + SLH Sbjct: 535 SSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRS--LPKIERSASEPSLH 587
>FGFR4_HUMAN (P22455) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) (CD334 antigen) Length = 802 Score = 71.6 bits (174), Expect = 2e-12 Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 4/145 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRGTLP--WMAPELL 429 + +H DL + N+LV + + K+ D GL++ V G LP WMAPE L Sbjct: 606 RKCIHRDLAARNVLVT----EDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEAL 661 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+SFGI++WE+ T G PY + + ++ R P C P+ Sbjct: 662 --FDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFS-LLREGHRMDRPPHCPPEL 718 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRL 177 LM +CW A P++RP+F ++V+ L Sbjct: 719 YGLMRECWHAAPSQRPTFKQLVEAL 743
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 71.6 bits (174), Expect = 2e-12 Identities = 55/157 (35%), Positives = 77/157 (49%), Gaps = 4/157 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G + + W APE L Sbjct: 383 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 438 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + ++ + P PE C Sbjct: 439 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE-CPESLH 494 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQ 138 LM QCW EP ERP+F + L TS T+P Q Sbjct: 495 DLMCQCWRKEPEERPTFEYLQAFLEDYFTS-TEPQYQ 530
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 71.6 bits (174), Expect = 2e-12 Identities = 45/143 (31%), Positives = 71/143 (49%), Gaps = 4/143 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRGTLP--WMAPELL 429 + +H DL + N+LV+ + K+ D GL++ ++ G LP WMAPE L Sbjct: 550 RRCIHRDLAARNVLVS----DDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESL 605 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 K DV+S+GI++WE++T G++PY + + + + R P C Sbjct: 606 Q--EKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNI 663 Query: 251 RSLMEQCWSAEPTERPSFTEVVK 183 LM QCW +RP FTE+V+ Sbjct: 664 YILMRQCWHFNADDRPPFTEIVE 686
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 71.6 bits (174), Expect = 2e-12 Identities = 51/166 (30%), Positives = 81/166 (48%), Gaps = 7/166 (4%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 VH DL + N+L+N +CKV D GLS+V + G + + W APE + Sbjct: 799 VHRDLAARNILIN----SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-- 852 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + + DV+S+GIVMWE+++ GE PY ++ +I + P P C Sbjct: 853 AFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPS-PMDCPAALYQ 911 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSPT--KPLLQK*TALSSL 114 LM CW + RP F ++V L + +P+ K L+ + +S+L Sbjct: 912 LMLDCWQKDRNSRPKFDDIVNMLDKLIRNPSSLKTLVNASSRVSTL 957
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 71.6 bits (174), Expect = 2e-12 Identities = 55/157 (35%), Positives = 77/157 (49%), Gaps = 4/157 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G + + W APE L Sbjct: 388 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 443 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + ++ + P PE C Sbjct: 444 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE-CPESLH 499 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQ 138 LM QCW EP ERP+F + L TS T+P Q Sbjct: 500 DLMCQCWRKEPEERPTFEYLQAFLEDYFTS-TEPQYQ 535
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2)| (C-Fes) Length = 820 Score = 71.6 bits (174), Expect = 2e-12 Identities = 50/148 (33%), Positives = 76/148 (51%), Gaps = 4/148 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG--GVRGT-LPWMAPELL 429 K +H DL + N LV ++ + K+ D G+S+ + + + G+R + W APE L Sbjct: 675 KCCIHRDLAARNCLVT----EKNVLKISDFGMSREEADGIYAACSGLRQVPVKWTAPEAL 730 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 N S + DV+SFGI++WE + G PY +L V R PE C Sbjct: 731 NYGR--YSSESDVWSFGILLWETFSLGASPYPNLT-NQQTREFVEKGHRLPCPELCPDAV 787 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAM 168 LMEQCW+ EP +RPSF+ + + L ++ Sbjct: 788 FRLMEQCWAYEPGQRPSFSIICQELHSI 815
>ROR1_HUMAN (Q01973) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) Length = 937 Score = 71.6 bits (174), Expect = 2e-12 Identities = 56/179 (31%), Positives = 83/179 (46%), Gaps = 15/179 (8%) Frame = -1 Query: 638 GWMLHLVWNICTGKN------IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTL 480 G LH+ I G VH DL + N+L+ ++ K+ DLGLS+ + Sbjct: 590 GDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIG----EQLHVKISDLGLSREIYSADY 645 Query: 479 ISGGVRGTLP--WMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIG 309 + LP WM PE + S D++SFG+V+WE+ + G +PY +I Sbjct: 646 YRVQSKSLLPIRWMPPEAIMYGK--FSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIE 703 Query: 308 GIVNNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMA-----TSPTKP 147 + L P E C P+ SLM +CW+ P+ RP F ++ RLR+ TS T P Sbjct: 704 MVRKRQLLPC-SEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTP 761
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 71.6 bits (174), Expect = 2e-12 Identities = 54/172 (31%), Positives = 89/172 (51%), Gaps = 9/172 (5%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVR---GTLPWMAPELL 429 KNI+H D+KS+N+ ++ + K+GD GL+ VK + S V G++ WMAPE++ Sbjct: 462 KNIIHRDMKSNNIFLH----EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVI 517 Query: 428 N-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAII-----GGIVNNTLRPLVPES 267 N S + DV+S+GIV++EL+ GE PYA ++ I G + L L ++ Sbjct: 518 RMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLY-KN 576 Query: 266 CDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQK*TALSSLH 111 C + L+ C ERP F +++ + + S P + + + SLH Sbjct: 577 CPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS--LPKINRSASEPSLH 626
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 71.2 bits (173), Expect = 2e-12 Identities = 49/147 (33%), Positives = 74/147 (50%), Gaps = 3/147 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELLN 426 K +H DL + N+LV + K+ D GLS+ + + G LP WMA E LN Sbjct: 969 KQFIHRDLAARNVLVG----ENLASKIADFGLSRG--EEVYVKKTMGRLPVRWMAIESLN 1022 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 S + + K DV+SFG+++WE+++ G PY + + + R P +CD + Sbjct: 1023 YS--VYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQG-YRMEQPRNCDDEVY 1079 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAM 168 LM QCW P ERP F ++ +L M Sbjct: 1080 ELMRQCWRDRPYERPPFAQIALQLGRM 1106
>ACK1_MOUSE (O54967) Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1)| (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2) Length = 1055 Score = 71.2 bits (173), Expect = 2e-12 Identities = 45/139 (32%), Positives = 69/139 (49%), Gaps = 5/139 (3%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT----LISGGVRGTLPWMAPEL 432 K +H DL + NLL+ RD + K+GD GL + Q ++ + W APE Sbjct: 246 KRFIHRDLAARNLLLATRD----LVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 301 Query: 431 LNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQ 255 L + S D + FG+ +WE+ T G+EP+ L+ I+ I R PE C Sbjct: 302 LK--TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 359 Query: 254 WRSLMEQCWSAEPTERPSF 198 ++M QCW+ +P +RP+F Sbjct: 360 IYNVMVQCWAHKPEDRPTF 378
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 71.2 bits (173), Expect = 2e-12 Identities = 46/137 (33%), Positives = 70/137 (51%), Gaps = 4/137 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N +H DL+S N+LV +CK+ D GL+++ + G + + W APE L Sbjct: 384 NYIHRDLRSANILVG----DNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL+T G PY ++ ++ + P P+ C Sbjct: 440 GRFTI---KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPC-PQDCPASLH 495 Query: 248 SLMEQCWSAEPTERPSF 198 LM QCW +P ERP+F Sbjct: 496 ELMLQCWKKDPEERPTF 512
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 71.2 bits (173), Expect = 2e-12 Identities = 55/175 (31%), Positives = 90/175 (51%), Gaps = 12/175 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGV-----RGTLPWMAPE 435 KNI+H DLKS+N+ ++ + K+GD GL+ VK T SG G++ WMA E Sbjct: 423 KNIIHRDLKSNNIFLH----EGLTVKIGDFGLATVK--TRWSGAQPLEQPSGSVLWMAAE 476 Query: 434 LLNGSS-NLVSEKVDVFSFGIVMWELLTGEEPYADLHYGA---IIGGIVNNTLRP---LV 276 ++ N S + DV+++G+V++EL+TG PY+ H G II + L P + Sbjct: 477 VIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYS--HIGCRDQIIFMVGRGYLSPDLSKI 534 Query: 275 PESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQK*TALSSLH 111 +C R L+ C + ERP F +++ + + S P +++ + SLH Sbjct: 535 SSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRS--LPKIERSASEPSLH 587
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 71.2 bits (173), Expect = 2e-12 Identities = 44/154 (28%), Positives = 79/154 (51%), Gaps = 11/154 (7%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK----VKCQTLISGGVRGTLPWMAPEL 432 ++I+H DLK N+L++ +D +CK+ D G S+ ++C+ + GT APE+ Sbjct: 223 QSILHLDLKPANILISEQD----VCKISDFGCSQKLQDLRCRQASPHHIGGTYTHQAPEI 278 Query: 431 LNGSSNLVSEKVDVFSFGIVMWELLTGEEPYA-DLHYGAIIGGIVNNTLRP------LVP 273 L G + + K D++SFGI +W++ T E PY+ + Y + +V LRP Sbjct: 279 LKGE--IATPKADIYSFGITLWQMTTREVPYSGEPQY--VQYAVVAYNLRPSLAGAVFTA 334 Query: 272 ESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRA 171 +++++ CW A +RP + + L+A Sbjct: 335 SLTGKTLQNIIQSCWEARALQRPGAELLQRDLKA 368
>ACK1_HUMAN (Q07912) Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine| kinase non-receptor protein 2) Length = 1036 Score = 71.2 bits (173), Expect = 2e-12 Identities = 45/139 (32%), Positives = 69/139 (49%), Gaps = 5/139 (3%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT----LISGGVRGTLPWMAPEL 432 K +H DL + NLL+ RD + K+GD GL + Q ++ + W APE Sbjct: 246 KRFIHRDLAARNLLLATRD----LVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 301 Query: 431 LNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQ 255 L + S D + FG+ +WE+ T G+EP+ L+ I+ I R PE C Sbjct: 302 LK--TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 359 Query: 254 WRSLMEQCWSAEPTERPSF 198 ++M QCW+ +P +RP+F Sbjct: 360 IYNVMVQCWAHKPEDRPTF 378
>MOS_XENLA (P12965) Serine/threonine-protein kinase mos (EC 2.7.11.1)| (pp39-mos) Length = 359 Score = 71.2 bits (173), Expect = 2e-12 Identities = 50/154 (32%), Positives = 83/154 (53%), Gaps = 15/154 (9%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVGDLGLS-KVKCQTLISGG---------VRGTLPWM 444 +VH DLK N+L+ D +CK+GD G S +++ +GG V GT Sbjct: 185 VVHLDLKPANVLLAPGD----LCKIGDFGCSQRLREGDEAAGGEPCCTQLRHVGGTYTHR 240 Query: 443 APELLNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRP----LV 276 APELL G V+ K D++SF I +W++++ E PY ++ +V LRP L Sbjct: 241 APELLKGEP--VTAKADIYSFAITLWQMVSRELPYTGDRQ-CVLYAVVAYDLRPEMGPLF 297 Query: 275 PESCDPQW-RSLMEQCWSAEPTERPSFTEVVKRL 177 + + + R++++ CW+A P ERP+ ++++RL Sbjct: 298 SHTEEGRAARTIVQSCWAARPQERPNAEQLLERL 331
>TIE1_HUMAN (P35590) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1138 Score = 71.2 bits (173), Expect = 2e-12 Identities = 49/147 (33%), Positives = 74/147 (50%), Gaps = 3/147 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELLN 426 K +H DL + N+LV + K+ D GLS+ + + G LP WMA E LN Sbjct: 973 KQFIHRDLAARNVLVG----ENLASKIADFGLSRG--EEVYVKKTMGRLPVRWMAIESLN 1026 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 S + + K DV+SFG+++WE+++ G PY + + + R P +CD + Sbjct: 1027 YS--VYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQG-YRMEQPRNCDDEVY 1083 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAM 168 LM QCW P ERP F ++ +L M Sbjct: 1084 ELMRQCWRDRPYERPPFAQIALQLGRM 1110
>ACK2_BOVIN (O02742) Activated CDC42 kinase 2 (EC 2.7.10.2) (ACK-2)| Length = 747 Score = 71.2 bits (173), Expect = 2e-12 Identities = 45/139 (32%), Positives = 69/139 (49%), Gaps = 5/139 (3%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT----LISGGVRGTLPWMAPEL 432 K +H DL + NLL+ RD + K+GD GL + Q ++ + W APE Sbjct: 246 KRFIHRDLAARNLLLATRD----LVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 301 Query: 431 LNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQ 255 L + S D + FG+ +WE+ T G+EP+ L+ I+ I R PE C Sbjct: 302 LK--TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 359 Query: 254 WRSLMEQCWSAEPTERPSF 198 ++M QCW+ +P +RP+F Sbjct: 360 IYNVMVQCWAHKPEDRPTF 378
>KFMS_FSVMD (P00545) Tyrosine-protein kinase transforming protein fms (EC| 2.7.10.1) Length = 978 Score = 71.2 bits (173), Expect = 2e-12 Identities = 43/149 (28%), Positives = 74/149 (49%), Gaps = 4/149 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV---KCQTLISGGVRGTLPWMAPELL 429 KN +H D+ + N+L+ + K+GD GL++ ++ G R + WMAPE + Sbjct: 804 KNCIHRDVAARNVLLT----SGRVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESI 859 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 V DV+S+GI++WE+ + G PY + + +V + + P Sbjct: 860 FDCVYTVQS--DVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNI 917 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMA 165 S+M+ CW+ EPT RP+F ++ L+ A Sbjct: 918 YSIMQACWALEPTRRPTFQQICSLLQKQA 946
>CSF1R_FELCA (P13369) Macrophage colony-stimulating factor 1 receptor precursor| (CSF-1-R) (EC 2.7.10.1) (Fms proto-oncogene) (c-fms) Length = 980 Score = 71.2 bits (173), Expect = 2e-12 Identities = 43/149 (28%), Positives = 74/149 (49%), Gaps = 4/149 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV---KCQTLISGGVRGTLPWMAPELL 429 KN +H D+ + N+L+ + K+GD GL++ ++ G R + WMAPE + Sbjct: 770 KNCIHRDVAARNVLLT----SGRVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESI 825 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 V DV+S+GI++WE+ + G PY + + +V + + P Sbjct: 826 FDCVYTVQS--DVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNI 883 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMA 165 S+M+ CW+ EPT RP+F ++ L+ A Sbjct: 884 YSIMQACWALEPTRRPTFQQICSLLQKQA 912
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 71.2 bits (173), Expect = 2e-12 Identities = 52/155 (33%), Positives = 75/155 (48%), Gaps = 4/155 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G + + W APE L Sbjct: 380 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 435 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + ++ + P PE C Sbjct: 436 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE-CPESLH 491 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPL 144 LM QCW +P ERP+F + L TS P+ Sbjct: 492 DLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPPV 526
>VGFR3_HUMAN (P35916) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1298 Score = 71.2 bits (173), Expect = 2e-12 Identities = 44/145 (30%), Positives = 75/145 (51%), Gaps = 4/145 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT---LISGGVRGTLPWMAPELL 429 + +H DL + N+L++ D + K+ D GL++ + + G R L WMAPE + Sbjct: 1031 RKCIHRDLAARNILLSESD----VVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESI 1086 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+SFG+++WE+ + G PY + + + R PE P Sbjct: 1087 --FDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAI 1144 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRL 177 R +M CWS +P RP+F+E+V+ L Sbjct: 1145 RRIMLNCWSGDPKARPAFSELVEIL 1169
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 71.2 bits (173), Expect = 2e-12 Identities = 49/147 (33%), Positives = 74/147 (50%), Gaps = 3/147 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELLN 426 K +H DL + N+LV + K+ D GLS+ + + G LP WMA E LN Sbjct: 971 KQFIHRDLAARNVLVG----ENLASKIADFGLSRG--EEVYVKKTMGRLPVRWMAIESLN 1024 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 S + + K DV+SFG+++WE+++ G PY + + + R P +CD + Sbjct: 1025 YS--VYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ-AYRMEQPRNCDDEVY 1081 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAM 168 LM QCW P ERP F ++ +L M Sbjct: 1082 ELMRQCWRDRPYERPPFAQIALQLGRM 1108
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 71.2 bits (173), Expect = 2e-12 Identities = 58/175 (33%), Positives = 82/175 (46%), Gaps = 14/175 (8%) Frame = -1 Query: 593 IVHFDLKSDNLLVNLRDPQRPICKVG---DLGLSKVKCQTLISGGVRGTLPWMAPELLNG 423 IVH D+K N+L+ + IC G D+ +K Q GTL +MAPE + Sbjct: 129 IVHRDIKPQNMLLYNQHEDLKICDFGLATDMSNNKTDMQ--------GTLRYMAPEAIKH 180 Query: 422 SSNLVSEKVDVFSFGIVMWELLTGEEPYADLH----YGAIIGGIVNNTLRPL--VPESCD 261 + K DV+SFGI++WEL+T + PY+ L AI+ I + P+ V C Sbjct: 181 LK--YTAKCDVYSFGIMLWELMTRQLPYSHLENPNSQYAIMKAISSGEKLPMEAVRSDCP 238 Query: 260 PQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPT-----KPLLQK*TALSSLH 111 + LME C P +RPS E+ K L S T KPL + A+ + H Sbjct: 239 EGIKQLMECCMDINPEKRPSMKEIEKFLGEQYESGTDEDFIKPLDEDTVAVVTYH 293
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 71.2 bits (173), Expect = 2e-12 Identities = 44/137 (32%), Positives = 72/137 (52%), Gaps = 3/137 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPELLN 426 +N +H DL++ N+LV+ CK+ D GL+++ + G + + W APE +N Sbjct: 357 RNYIHRDLRAANILVS----DTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 412 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + + K DV+SFGI+M E++T G PY + +I + P P++C + Sbjct: 413 YGTFTI--KSDVWSFGILMTEIVTHGRIPYPGMTNPEVIQNLERGYRMPR-PDNCPEELY 469 Query: 248 SLMEQCWSAEPTERPSF 198 LM QCW P +RP+F Sbjct: 470 KLMMQCWRERPDDRPTF 486
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 71.2 bits (173), Expect = 2e-12 Identities = 49/164 (29%), Positives = 79/164 (48%), Gaps = 9/164 (5%) Frame = -1 Query: 632 MLHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG 471 +L++ I +G +N +H DL + N LV + KV D GL+++ + Sbjct: 469 LLYMATQIASGMSYLESRNYIHRDLAARNCLVG----DNKLVKVADFGLARLMRDDTYTA 524 Query: 470 --GVRGTLPWMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIV 300 G + + W APE L + N S K DV++FG+++WE+ T G PY + + + Sbjct: 525 HAGAKFPIKWTAPEGL--AYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKL- 581 Query: 299 NNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAM 168 + R P C P+ LM QCW + T+RP+F + L M Sbjct: 582 DKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHM 625
>CSF1R_HUMAN (P07333) Macrophage colony-stimulating factor 1 receptor precursor| (CSF-1-R) (EC 2.7.10.1) (Fms proto-oncogene) (c-fms) (CD115 antigen) Length = 972 Score = 70.9 bits (172), Expect = 3e-12 Identities = 43/149 (28%), Positives = 74/149 (49%), Gaps = 4/149 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV---KCQTLISGGVRGTLPWMAPELL 429 KN +H D+ + N+L+ + K+GD GL++ ++ G R + WMAPE + Sbjct: 772 KNCIHRDVAARNVLLT----NGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESI 827 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 V DV+S+GI++WE+ + G PY + + +V + + P Sbjct: 828 FDCVYTVQS--DVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNI 885 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLRAMA 165 S+M+ CW+ EPT RP+F ++ L+ A Sbjct: 886 YSIMQACWALEPTHRPTFQQICSFLQEQA 914
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 70.9 bits (172), Expect = 3e-12 Identities = 49/144 (34%), Positives = 76/144 (52%), Gaps = 3/144 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRGTLPWMAPELLNG 423 +N +H DL + N+LV + +CKVGD GL++ VK +S W APE L Sbjct: 306 QNYIHRDLAARNVLVT----ENNLCKVGDFGLARLVKEDIYLSHEHNVPYKWTAPEAL-- 359 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADL-HYGAIIGGIVNNTLRPLVPESCDPQWR 249 S S K DV+SFG+++ E+ + G+ PY + ++ + V+ R P C P Sbjct: 360 SRGHYSIKSDVWSFGVLLHEIFSRGQMPYPGMSNHETFLR--VDAGYRMPCPLECPPNIH 417 Query: 248 SLMEQCWSAEPTERPSFTEVVKRL 177 LM CWS +P +RP F ++ ++L Sbjct: 418 KLMLSCWSRDPKQRPCFKDLCEKL 441
>MOS_CHICK (P10741) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) Length = 349 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/153 (30%), Positives = 73/153 (47%), Gaps = 9/153 (5%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGG----VRGTLPWMAPEL 432 + IVH DLK N+L+ + CK+GD G S+ + L GT APEL Sbjct: 199 QGIVHLDLKPANILIT----EHGACKIGDFGCSQRLEEGLSQSHHVCQQGGTYTHRAPEL 254 Query: 431 LNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRPLV-----PES 267 L G V+ K D++SF I +W+++ E+PY + + N PL + Sbjct: 255 LKGER--VTAKADIYSFAITLWQIVMREQPYLGERQYVLYAVVAYNLRPPLAAAIFHESA 312 Query: 266 CDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAM 168 + RS++ CW A+ ER S +++ LRA+ Sbjct: 313 VGQRLRSIISCCWKADVEERLSAAQLLPSLRAL 345
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 70.9 bits (172), Expect = 3e-12 Identities = 48/150 (32%), Positives = 76/150 (50%), Gaps = 3/150 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG--GVRGTLPWMAPELLN 426 +N +H DL + N+LV I K+ D GL+++ + G R + W APE N Sbjct: 364 QNYIHRDLAARNVLVG----DGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAAN 419 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 S S K DV+SFGI++ EL+T G PY + ++ + + P P +C+P+ Sbjct: 420 YSK--FSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQ-PPNCEPRLY 476 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATS 159 +M +CW +P RP+F + +L TS Sbjct: 477 EIMLECWHKDPMRRPTFETLQWKLEDFYTS 506
>FGFR4_RAT (Q498D6) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) Length = 800 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 4/145 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRGTLP--WMAPELL 429 + +H DL + N+LV D + K+ D GL++ V G LP WMAPE L Sbjct: 604 RKCIHRDLAARNVLVTEDD----VMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEAL 659 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+SFGI++WE+ T G PY + + ++ R P +C + Sbjct: 660 --FDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFS-LLREGHRMERPPNCPSEL 716 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRL 177 LM +CW A P++RP+F ++V+ L Sbjct: 717 YGLMRECWHAAPSQRPTFKQLVEAL 741
>IGF1R_XENLA (O73798) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (xIGF-1R) (xIGFR) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1358 Score = 70.9 bits (172), Expect = 3e-12 Identities = 45/143 (31%), Positives = 73/143 (51%), Gaps = 4/143 (2%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMAPELLNGS 420 VH DL + N +V + K+GD G+++ +T G +G LP WM+PE L Sbjct: 1128 VHRDLAARNCMVT----EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLK-- 1181 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 + + DV+SFG+V+WE+ T E+PY + ++ ++ L P++C L Sbjct: 1182 DGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLEK-PDNCPDMLFEL 1240 Query: 242 MEQCWSAEPTERPSFTEVVKRLR 174 M CW P RPSF E++ ++ Sbjct: 1241 MRMCWQFNPKMRPSFLEIISSIK 1263
>MOS_MOUSE (P00536) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 390 Score = 70.9 bits (172), Expect = 3e-12 Identities = 44/154 (28%), Positives = 79/154 (51%), Gaps = 11/154 (7%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK----VKCQTLISGGVRGTLPWMAPEL 432 ++I+H DLK N+L++ +D +CK+ D G S+ ++C+ + GT APE+ Sbjct: 239 QSILHLDLKPANILISEQD----VCKISDFGCSQKLQVLRCRQASPHHIGGTYTHQAPEI 294 Query: 431 LNGSSNLVSEKVDVFSFGIVMWELLTGEEPYA-DLHYGAIIGGIVNNTLRP------LVP 273 L G + + K D++SFGI +W++ T E PY+ + Y + +V LRP Sbjct: 295 LKGE--IATPKADIYSFGITLWQMTTREVPYSGEPQY--VQYAVVAYNLRPSLAGAVFTA 350 Query: 272 ESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRA 171 +++++ CW A +RP + + L+A Sbjct: 351 SLTGKTLQNIIQSCWEARALQRPCAELLQRDLKA 384
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 70.5 bits (171), Expect = 4e-12 Identities = 50/157 (31%), Positives = 77/157 (49%), Gaps = 4/157 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N +H DL++ N+LV +CK+ D GL+++ + G + + W APE L Sbjct: 391 NYIHRDLRAANILV----ADNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 446 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL+T G PY + ++ + P P+ C Sbjct: 447 GRFTI---KSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVDRGYRMPC-PQGCPESLH 502 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQ 138 +M QCW EP ERP+F + L T+ T+P Q Sbjct: 503 EMMRQCWKKEPDERPTFEYIQSFLEDYFTA-TEPQYQ 538
>HTK7_HYDAT (Q25197) Putative insulin-like peptide receptor precursor (EC| 2.7.10.1) Length = 1477 Score = 70.5 bits (171), Expect = 4e-12 Identities = 47/142 (33%), Positives = 70/142 (49%), Gaps = 4/142 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRGTLP--WMAPELL 429 + VH DL + N +V K+GD G+++ + + + LP WMAPE L Sbjct: 1169 RKFVHCDLAARNCMV----ASDFTVKIGDFGMARDIYERNYYRKDGKSLLPIRWMAPESL 1224 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + S DV+SFG+V+WE+ T +PY ++ +++N PE CD Q Sbjct: 1225 K--DGIFSTASDVWSFGVVLWEICTLASQPYQGKTNEQVLNFVLSNGHLDY-PEGCDYQL 1281 Query: 251 RSLMEQCWSAEPTERPSFTEVV 186 R M CW +P RPSF E+V Sbjct: 1282 REFMSLCWHRDPKMRPSFLEIV 1303
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 70.5 bits (171), Expect = 4e-12 Identities = 49/137 (35%), Positives = 69/137 (50%), Gaps = 4/137 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G + + W APE L Sbjct: 383 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 438 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + ++ + P PE C Sbjct: 439 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE-CPESLH 494 Query: 248 SLMEQCWSAEPTERPSF 198 LM QCW EP ERP+F Sbjct: 495 DLMCQCWRKEPEERPTF 511
>IGF1R_BOVIN (Q05688) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (F Length = 640 Score = 70.5 bits (171), Expect = 4e-12 Identities = 46/143 (32%), Positives = 73/143 (51%), Gaps = 4/143 (2%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMAPELLNGS 420 VH DL + N +V + K+GD G+++ +T G +G LP WM+PE L Sbjct: 405 VHRDLAARNCMV----AEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLK-- 458 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 + + DV+SFG+V+WE+ T E+PY L ++ ++ L P++C L Sbjct: 459 DGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDK-PDNCPDMLFEL 517 Query: 242 MEQCWSAEPTERPSFTEVVKRLR 174 M CW P RPSF E++ ++ Sbjct: 518 MRMCWQYNPKMRPSFLEIISSVK 540
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 70.5 bits (171), Expect = 4e-12 Identities = 54/157 (34%), Positives = 77/157 (49%), Gaps = 4/157 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G + + W APE L Sbjct: 380 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 435 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + ++ + P PE C Sbjct: 436 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE-CPESLH 491 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQ 138 LM QCW +P ERP+F + L TS T+P Q Sbjct: 492 DLMCQCWRKDPEERPTFEYLQAFLEDYFTS-TEPQYQ 527
>ROS_AVISU (P00529) Tyrosine-protein kinase transforming protein ros (EC| 2.7.10.1) Length = 402 Score = 70.5 bits (171), Expect = 4e-12 Identities = 51/171 (29%), Positives = 85/171 (49%), Gaps = 12/171 (7%) Frame = -1 Query: 632 MLHLVWNICTG------KNIVHFDLKSDNLLVNLRD--PQRPICKVGDLGLSK-VKCQTL 480 +L + +IC G +H DL + N LV+ + + K+GD GL++ + Sbjct: 209 LLDICLDICKGCVYLEKMRFIHRDLAARNCLVSEKQYGSCSRVVKIGDFGLARDIYKNDY 268 Query: 479 ISGGVRGTLP--WMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIG 309 G LP WMAPE L + + DV++FG+++WE LT G++PY L ++ Sbjct: 269 YRKRGEGLLPVRWMAPESL--IDGVFTNHSDVWAFGVLVWETLTLGQQPYPGLSNIEVLH 326 Query: 308 GIVNNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 + + R P +C R LM +CW+ +P RP+F + +L+ + SP Sbjct: 327 HVRSGG-RLESPNNCPDDIRDLMTRCWAQDPHNRPTFFYIQHKLQEIRHSP 376
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 70.5 bits (171), Expect = 4e-12 Identities = 47/150 (31%), Positives = 73/150 (48%), Gaps = 5/150 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 VH DL + N+L+N +CKV D GLS+V + G + + W +PE + Sbjct: 743 VHRDLAARNILIN----SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAM-- 796 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 S + DV+S+GIV+WE+++ GE PY+ + +I V+ R P C Sbjct: 797 SYRKFTSASDVWSYGIVLWEVMSYGERPYSQMSNQDVIKA-VDERYRLPPPMDCPAALYQ 855 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP F ++V L + +P Sbjct: 856 LMLDCWQKDRNNRPKFEQIVSILDKLIRNP 885
>IGF1R_HUMAN (P08069) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 recepto Length = 1367 Score = 70.5 bits (171), Expect = 4e-12 Identities = 46/143 (32%), Positives = 73/143 (51%), Gaps = 4/143 (2%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMAPELLNGS 420 VH DL + N +V + K+GD G+++ +T G +G LP WM+PE L Sbjct: 1132 VHRDLAARNCMV----AEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLK-- 1185 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 + + DV+SFG+V+WE+ T E+PY L ++ ++ L P++C L Sbjct: 1186 DGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDK-PDNCPDMLFEL 1244 Query: 242 MEQCWSAEPTERPSFTEVVKRLR 174 M CW P RPSF E++ ++ Sbjct: 1245 MRMCWQYNPKMRPSFLEIISSIK 1267
>IGF1R_MOUSE (Q60751) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1373 Score = 70.1 bits (170), Expect = 5e-12 Identities = 46/143 (32%), Positives = 73/143 (51%), Gaps = 4/143 (2%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMAPELLNGS 420 VH DL + N +V + K+GD G+++ +T G +G LP WM+PE L Sbjct: 1134 VHRDLAARNCMV----AEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLK-- 1187 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 + + DV+SFG+V+WE+ T E+PY L ++ ++ L P++C L Sbjct: 1188 DGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDK-PDNCPDMLFEL 1246 Query: 242 MEQCWSAEPTERPSFTEVVKRLR 174 M CW P RPSF E++ ++ Sbjct: 1247 MRMCWQYNPKMRPSFLEIIGSIK 1269
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 70.1 bits (170), Expect = 5e-12 Identities = 51/159 (32%), Positives = 83/159 (52%), Gaps = 9/159 (5%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVR---GTLPWMAPELL 429 KNI+H D+KS+N+ ++ + K+GD GL+ VK + S V G++ WMAPE++ Sbjct: 137 KNIIHRDMKSNNIFLH----EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVI 192 Query: 428 N-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAII-----GGIVNNTLRPLVPES 267 N S + DV+S+GIV++EL+ GE PYA ++ I G + L L ++ Sbjct: 193 RMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLY-KN 251 Query: 266 CDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTK 150 C + L+ C ERP F +++ + + S K Sbjct: 252 CPKAIKRLVADCVKKVKEERPLFPQILSSIELLQHSLPK 290
>IGF1R_RAT (P24062) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1370 Score = 70.1 bits (170), Expect = 5e-12 Identities = 46/143 (32%), Positives = 73/143 (51%), Gaps = 4/143 (2%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMAPELLNGS 420 VH DL + N +V + K+GD G+++ +T G +G LP WM+PE L Sbjct: 1133 VHRDLAARNCMV----AEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLK-- 1186 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 + + DV+SFG+V+WE+ T E+PY L ++ ++ L P++C L Sbjct: 1187 DGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDK-PDNCPDMLFEL 1245 Query: 242 MEQCWSAEPTERPSFTEVVKRLR 174 M CW P RPSF E++ ++ Sbjct: 1246 MRMCWQYNPKMRPSFLEIIGSIK 1268
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 70.1 bits (170), Expect = 5e-12 Identities = 64/183 (34%), Positives = 81/183 (44%), Gaps = 18/183 (9%) Frame = -1 Query: 629 LHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISG- 471 LHL +I G K + H DL S N LV R+ + VGD GL++ K G Sbjct: 148 LHLALDIAQGLRYLHAKGVFHRDLTSKNCLVR-REDRGFTAVVGDFGLAE-KIPVYREGT 205 Query: 470 -----GVRGTLPWMAPELLNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGG 306 V G+ WMAPE+L G L EK DVF+FGIV+ EL+ D G Sbjct: 206 RKEPLAVVGSPYWMAPEVLRGE--LYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFG 263 Query: 305 IVNNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAM------ATSPTKPL 144 + R LV C + L C S EP+ R FTE+ + L + AT KP Sbjct: 264 LDVPAFRTLVGNDCPLPFLLLAIHCCSMEPSTRAPFTEITQHLEQILEQQPEATPLAKPP 323 Query: 143 LQK 135 L K Sbjct: 324 LTK 326
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 70.1 bits (170), Expect = 5e-12 Identities = 55/175 (31%), Positives = 91/175 (52%), Gaps = 12/175 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGV-----RGTLPWMAPE 435 KNI+H DLKS+N+ ++ + K+GD GL+ VK T SG G++ WMA E Sbjct: 421 KNIIHRDLKSNNIFLH----EGLTVKIGDFGLATVK--TRWSGAQPLEQPSGSVLWMAAE 474 Query: 434 LLNGSS-NLVSEKVDVFSFGIVMWELLTGEEPYADLHYGA---IIGGIVNNTLRP---LV 276 ++ N S + DV+++G+V++EL+TG PY+ H G+ II + L P + Sbjct: 475 VIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYS--HIGSRDQIIFMVGRGYLSPDLSKI 532 Query: 275 PESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQK*TALSSLH 111 +C R L+ C + ERP F +++ + + S P +++ + SLH Sbjct: 533 FSNCPKAMRRLLTDCLKFQREERPLFPQILATIELLQRS--LPKIERSASEPSLH 585
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 70.1 bits (170), Expect = 5e-12 Identities = 55/175 (31%), Positives = 91/175 (52%), Gaps = 12/175 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGV-----RGTLPWMAPE 435 KNI+H DLKS+N+ ++ + K+GD GL+ VK T SG G++ WMA E Sbjct: 421 KNIIHRDLKSNNIFLH----EGLTVKIGDFGLATVK--TRWSGAQPLEQPSGSVLWMAAE 474 Query: 434 LLNGSS-NLVSEKVDVFSFGIVMWELLTGEEPYADLHYGA---IIGGIVNNTLRP---LV 276 ++ N S + DV+++G+V++EL+TG PY+ H G+ II + L P + Sbjct: 475 VIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYS--HIGSRDQIIFMVGRGYLSPDLSKI 532 Query: 275 PESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQK*TALSSLH 111 +C R L+ C + ERP F +++ + + S P +++ + SLH Sbjct: 533 FSNCPKAMRRLLTDCLKFQREERPLFPQILATIELLQRS--LPKIERSASEPSLH 585
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 70.1 bits (170), Expect = 5e-12 Identities = 46/167 (27%), Positives = 83/167 (49%), Gaps = 9/167 (5%) Frame = -1 Query: 632 MLHLVWNICTGKN------IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK--VKCQTLI 477 +L + ++C G ++H DL + N LV + + KV D G+++ + Q Sbjct: 459 LLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG----ENQVIKVSDFGMTRFVLDDQYTS 514 Query: 476 SGGVRGTLPWMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIV 300 S G + + W +PE+ + S S K DV+SFG++MWE+ + G+ PY + ++ I Sbjct: 515 STGTKFPVKWASPEVFSFSR--YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI- 571 Query: 299 NNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATS 159 + R P +M CW P +RP+F+ ++++L +A S Sbjct: 572 STGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAES 618
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 70.1 bits (170), Expect = 5e-12 Identities = 50/160 (31%), Positives = 86/160 (53%), Gaps = 10/160 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVR---GTLPWMAPELL 429 KNI+H D+KS+N+ ++ + K+GD GL+ VK + S V G++ WMAPE++ Sbjct: 453 KNIIHRDMKSNNIFLH----EGLTVKIGDFGLATVKTRWSGSQQVEQLTGSILWMAPEVI 508 Query: 428 N-GSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAII------GGIVNNTLRPLVPE 270 +N S + DV+S+GIV++EL+TGE PY+ + I GG+V + + + + Sbjct: 509 RMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHIRDRDQIIFLVGRGGVVPDLSK--LYK 566 Query: 269 SCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTK 150 +C + L+ ERP F +++ + + S K Sbjct: 567 NCPKAMKRLVADSIKKLRDERPLFPQILSSIELLQHSLPK 606
>BLK_MOUSE (P16277) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 498 Score = 70.1 bits (170), Expect = 5e-12 Identities = 40/136 (29%), Positives = 74/136 (54%), Gaps = 3/136 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV-KCQTLISGGVRGTLPWMAPELLNGS 420 N +H DL++ N+LV+ + CK+ D GL+++ + G + + W APE ++ Sbjct: 348 NSIHRDLRAANILVS----ETLCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIH-- 401 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQ-WRS 246 + + K DV+SFG+++ ++T G PY + +I + + P PE+C P+ + Sbjct: 402 FGVFTIKADVWSFGVLLMVIVTYGRVPYPGMSNPEVIRSLEHGYRMPC-PETCPPELYND 460 Query: 245 LMEQCWSAEPTERPSF 198 ++ +CW P ERP+F Sbjct: 461 IITECWRGRPEERPTF 476
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 70.1 bits (170), Expect = 5e-12 Identities = 43/137 (31%), Positives = 74/137 (54%), Gaps = 3/137 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPELLN 426 KN +H DL++ N+LV+ + +CK+ D GL++V + G + + W APE +N Sbjct: 360 KNYIHRDLRAANVLVS----ESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 415 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + K DV+SFGI+++E++T G+ PY ++ + P V E+C + Sbjct: 416 FGCFTI--KSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRV-ENCPDELY 472 Query: 248 SLMEQCWSAEPTERPSF 198 +M+ CW + ERP+F Sbjct: 473 DIMKMCWKEKAEERPTF 489
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 69.7 bits (169), Expect = 7e-12 Identities = 49/165 (29%), Positives = 79/165 (47%), Gaps = 10/165 (6%) Frame = -1 Query: 632 MLHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT---L 480 MLH+ IC+G ++ VH DL + N LV + K+GD G+S+ T Sbjct: 656 MLHIASQICSGMVYLASQHFVHRDLATRNCLVGAN----LLVKIGDFGMSRDVYSTDYYR 711 Query: 479 ISGGVRGTLPWMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGI 303 + G + WM PE + + + DV+SFG+++WE+ T G++P+ L +I I Sbjct: 712 VGGHTMLPIRWMPPESI--MYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECI 769 Query: 302 VNNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAM 168 + P C + +M CW EP +R + E+ K L A+ Sbjct: 770 TQGRVLER-PRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHAL 813
>INSR_MOUSE (P15208) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1372 Score = 69.7 bits (169), Expect = 7e-12 Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 5/147 (3%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMAPELL 429 K VH DL + N +V K+GD G+++ +T G +G LP WM+PE L Sbjct: 1143 KKFVHRDLAARNCMV----AHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESL 1198 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNT-LRPLVPESCDPQ 255 + + D++SFG+V+WE+ + E+PY L ++ +++ L P P++C + Sbjct: 1199 K--DGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDP--PDNCPER 1254 Query: 254 WRSLMEQCWSAEPTERPSFTEVVKRLR 174 LM CW P RP+F E+V L+ Sbjct: 1255 LTDLMRMCWQFNPKMRPTFLEIVNLLK 1281
>INSR_HUMAN (P06213) Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220| antigen) [Contains: Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1382 Score = 69.7 bits (169), Expect = 7e-12 Identities = 46/146 (31%), Positives = 74/146 (50%), Gaps = 4/146 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMAPELL 429 K VH DL + N +V K+GD G+++ +T G +G LP WMAPE L Sbjct: 1153 KKFVHRDLAARNCMV----AHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESL 1208 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + D++SFG+V+WE+ + E+PY L ++ +++ P++C + Sbjct: 1209 K--DGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQ-PDNCPERV 1265 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLR 174 LM CW P RP+F E+V L+ Sbjct: 1266 TDLMRMCWQFNPKMRPTFLEIVNLLK 1291
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 69.7 bits (169), Expect = 7e-12 Identities = 42/151 (27%), Positives = 76/151 (50%), Gaps = 8/151 (5%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK----VKCQTLISGGVRGTLPWMAPEL 432 ++I+H DLK N+L++ +D +CK+ D G S+ ++C+ + + GT APEL Sbjct: 190 QSILHLDLKPANILISEKD----VCKISDFGCSQKLQDLRCRPSLHH-IGGTYTHQAPEL 244 Query: 431 LNGSSNLVSEKVDVFSFGIVMWELLTGEEPYAD----LHYGAIIGGIVNNTLRPLVPESC 264 L G + + K D++SFGI +W++ T E PY+ + Y + + + Sbjct: 245 LKGE--IATPKADIYSFGITLWQMTTREVPYSGEPQYVQYAVVAYNLRPHWQAVFTASLT 302 Query: 263 DPQWRSLMEQCWSAEPTERPSFTEVVKRLRA 171 ++ ++ CW A +RP + K L+A Sbjct: 303 GKTLQNNVQSCWEARALQRPGAELLQKDLKA 333
>INSR_RAT (P15127) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1383 Score = 69.7 bits (169), Expect = 7e-12 Identities = 47/147 (31%), Positives = 76/147 (51%), Gaps = 5/147 (3%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT-LISGGVRGTLP--WMAPELL 429 K VH DL + N +V K+GD G+++ +T G +G LP WM+PE L Sbjct: 1154 KKFVHRDLAARNCMV----AHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESL 1209 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNT-LRPLVPESCDPQ 255 + + D++SFG+V+WE+ + E+PY L ++ +++ L P P++C + Sbjct: 1210 K--DGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDP--PDNCPER 1265 Query: 254 WRSLMEQCWSAEPTERPSFTEVVKRLR 174 LM CW P RP+F E+V L+ Sbjct: 1266 LTDLMRMCWQFNPKMRPTFLEIVNLLK 1292
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 69.7 bits (169), Expect = 7e-12 Identities = 53/154 (34%), Positives = 76/154 (49%), Gaps = 4/154 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G + + W APE L Sbjct: 380 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 435 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + ++ + P PE C Sbjct: 436 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE-CPESLH 491 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKP 147 LM QCW +P ERP+F + L TS T+P Sbjct: 492 DLMCQCWRKDPEERPTFEYLQAFLEDYFTS-TEP 524
>7LESS_DROME (P13368) Protein sevenless (EC 2.7.10.1)| Length = 2554 Score = 69.7 bits (169), Expect = 7e-12 Identities = 54/165 (32%), Positives = 80/165 (48%), Gaps = 8/165 (4%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRD---PQRPICKVGDLGLSK--VKCQTLISGGVRGTLP--WMAP 438 + VH DL N LV +R K+GD GL++ K G G LP WM+P Sbjct: 2338 HFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEG-EGLLPVRWMSP 2396 Query: 437 ELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCD 261 E L L + + DV++FG++ WE+LT G++PYA + ++ + R P C Sbjct: 2397 ESL--VDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGG-RLQQPPMCT 2453 Query: 260 PQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQK*TA 126 + SL+ CW +P ERPSF L A++T + + TA Sbjct: 2454 EKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATA 2498
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 69.7 bits (169), Expect = 7e-12 Identities = 48/147 (32%), Positives = 74/147 (50%), Gaps = 3/147 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELLN 426 + +VH DL + N+LV CKV D GL+++ + S +P W APE N Sbjct: 348 RRVVHRDLAARNVLVG----DDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAAN 403 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + S+K DV+SFGI+++E+ T G+ PY + + I P P C + Sbjct: 404 --YRVFSQKSDVWSFGILLYEVFTYGQCPYEGMTNHETLQQISRGYRLPR-PAVCPAEVY 460 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAM 168 LM +CW P ERP+F + ++L A+ Sbjct: 461 VLMVECWKGSPEERPTFAILREKLNAI 487
>PGFRA_MOUSE (P26618) Alpha platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-alpha) Length = 1089 Score = 69.7 bits (169), Expect = 7e-12 Identities = 47/148 (31%), Positives = 76/148 (51%), Gaps = 7/148 (4%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV---KCQTLISGGVRGTLPWMAPELL 429 KN VH DL + N+L+ Q I K+ D GL++ + G + WMAPE + Sbjct: 812 KNCVHRDLAARNVLL----AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESI 867 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 NL + DV+S+GI++WE+ + G PY + + + + R P+ + Sbjct: 868 --FDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEV 925 Query: 251 RSLMEQCWSAEPTERPSF---TEVVKRL 177 +M QCW++EP +RPSF +E+V+ L Sbjct: 926 YEIMVQCWNSEPEKRPSFYHLSEIVENL 953
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 69.7 bits (169), Expect = 7e-12 Identities = 42/137 (30%), Positives = 74/137 (54%), Gaps = 3/137 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPELLN 426 KN +H DL++ N+LV+ + +CK+ D GL++V + G + + W APE +N Sbjct: 360 KNYIHRDLRAANVLVS----ESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 415 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 + K DV+SFGI+++E++T G+ PY ++ + P + E+C + Sbjct: 416 FGCFTI--KSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRM-ENCPDELY 472 Query: 248 SLMEQCWSAEPTERPSF 198 +M+ CW + ERP+F Sbjct: 473 DIMKMCWKEKAEERPTF 489
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 69.7 bits (169), Expect = 7e-12 Identities = 46/150 (30%), Positives = 76/150 (50%), Gaps = 4/150 (2%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRGTLP--WMAPELLNGS 420 +H DL + N+LV + + K+ D GL++ + G LP WMAPE L Sbjct: 625 IHRDLAARNVLVT----ENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEAL--F 678 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 + + + DV+SFG++MWE+ T G PY + + ++ R P +C + + Sbjct: 679 DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK-LLKEGHRMDKPANCTNELYMM 737 Query: 242 MEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 M CW A P++RP+F ++V+ L + T T Sbjct: 738 MRDCWQAVPSQRPTFKQLVEDLDRILTLTT 767
>KSYK_MOUSE (P48025) Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine| kinase) Length = 629 Score = 69.7 bits (169), Expect = 7e-12 Identities = 49/146 (33%), Positives = 70/146 (47%), Gaps = 5/146 (3%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLP--WMAPELL 429 N VH DL + N+L+ + K+ D GLSK + G P W APE + Sbjct: 483 NFVHRDLAARNVLLVTQH----YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 538 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 N S K DV+SFG++MWE + G++PY + G+ + ++ R P C + Sbjct: 539 NYYK--FSSKSDVWSFGVLMWEAFSYGQKPYRGMK-GSEVTAMLEKGERMGCPAGCPREM 595 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRLR 174 LM CW+ + RP FT V RLR Sbjct: 596 YDLMNLCWTYDVENRPGFTAVELRLR 621
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 69.3 bits (168), Expect = 9e-12 Identities = 46/150 (30%), Positives = 76/150 (50%), Gaps = 4/150 (2%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRGTLP--WMAPELLNGS 420 +H DL + N+LV + + K+ D GL++ + G LP WMAPE L Sbjct: 623 IHRDLAARNVLVT----ENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEAL--F 676 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 + + + DV+SFG++MWE+ T G PY + + ++ R P +C + + Sbjct: 677 DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK-LLKEGHRMDKPTNCTNELYMM 735 Query: 242 MEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 M CW A P++RP+F ++V+ L + T T Sbjct: 736 MRDCWHAVPSQRPTFKQLVEDLDRILTLTT 765
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 69.3 bits (168), Expect = 9e-12 Identities = 46/150 (30%), Positives = 76/150 (50%), Gaps = 4/150 (2%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRGTLP--WMAPELLNGS 420 +H DL + N+LV + + K+ D GL++ + G LP WMAPE L Sbjct: 623 IHRDLAARNVLVT----ENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEAL--F 676 Query: 419 SNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSL 243 + + + DV+SFG++MWE+ T G PY + + ++ R P +C + + Sbjct: 677 DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK-LLKEGHRMDKPANCTNELYMM 735 Query: 242 MEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 M CW A P++RP+F ++V+ L + T T Sbjct: 736 MRDCWHAVPSQRPTFKQLVEDLDRILTLTT 765
>MOS_HUMAN (P00540) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 346 Score = 69.3 bits (168), Expect = 9e-12 Identities = 48/143 (33%), Positives = 74/143 (51%), Gaps = 10/143 (6%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK----VKCQTLISGGVRGTLPWMAPEL 432 ++IVH DLK N+L++ +D +CK+ D G S+ + C S + GT APEL Sbjct: 195 QSIVHLDLKPANILISEQD----VCKISDFGCSEKLEDLLCFQTPSYPLGGTYTHRAPEL 250 Query: 431 LNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTLRP----LVPESC 264 L G V+ K D++SF I +W++ T + PY+ I+ +V LRP V E Sbjct: 251 LKGEG--VTPKADIYSFAITLWQMTTKQAPYSG-ERQHILYAVVAYDLRPSLSAAVFEDS 307 Query: 263 DPQWR--SLMEQCWSAEPTERPS 201 P R ++++CW +RPS Sbjct: 308 LPGQRLGDVIQRCWRPSAAQRPS 330
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 69.3 bits (168), Expect = 9e-12 Identities = 47/141 (33%), Positives = 74/141 (52%), Gaps = 1/141 (0%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLPWMAPELLNGSS 417 N VH DL + N+LV+ + I KV D GL+K T +G + + W APE L Sbjct: 309 NFVHRDLAARNVLVS----EDNIAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALREKK 362 Query: 416 NLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRSLM 240 S K DV+SFGI++WE+ + G PY + ++ V + P+ C +M Sbjct: 363 --FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR-VEKGYKMDPPDGCPAIVYEVM 419 Query: 239 EQCWSAEPTERPSFTEVVKRL 177 ++CW+ +P RPSF ++ ++L Sbjct: 420 KKCWTLDPGHRPSFHQLREQL 440
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 69.3 bits (168), Expect = 9e-12 Identities = 48/137 (35%), Positives = 69/137 (50%), Gaps = 4/137 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G + + W APE L Sbjct: 380 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 435 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + ++ + P PE C Sbjct: 436 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE-CPESLH 491 Query: 248 SLMEQCWSAEPTERPSF 198 LM QCW +P ERP+F Sbjct: 492 DLMCQCWRKDPEERPTF 508
>PTK7_HUMAN (Q13308) Tyrosine-protein kinase-like 7 precursor (Colon carcinoma| kinase 4) (CCK-4) Length = 1070 Score = 69.3 bits (168), Expect = 9e-12 Identities = 53/157 (33%), Positives = 78/157 (49%), Gaps = 4/157 (2%) Frame = -1 Query: 605 TGKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK--VKCQTLISGGVRGTLPWMAPE- 435 + VH DL + N LV+ QR + KV LGLSK + L WM+PE Sbjct: 922 SNNRFVHKDLAARNCLVSA---QRQV-KVSALGLSKDVYNSEYYHFRQAWVALRWMSPEA 977 Query: 434 LLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDP 258 +L G S K DV++ G++MWE+ T GE P+ ++ + R PE C Sbjct: 978 ILEGD---FSTKSDVWASGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPS 1034 Query: 257 QWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKP 147 + LM++CW+ P +RPSF+E+ L +T +KP Sbjct: 1035 KLYRLMQRCWALSPKDRPSFSEIASAL-GDSTVDSKP 1070
>PGFRA_RAT (P20786) Alpha platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-alpha) Length = 1088 Score = 69.3 bits (168), Expect = 9e-12 Identities = 46/148 (31%), Positives = 76/148 (51%), Gaps = 7/148 (4%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV---KCQTLISGGVRGTLPWMAPELL 429 KN VH DL + N+L+ Q I K+ D GL++ + G + WMAPE + Sbjct: 811 KNCVHRDLAARNVLL----AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESI 866 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 NL + DV+S+G+++WE+ + G PY + + + + R P+ + Sbjct: 867 --FDNLYTTLSDVWSYGVLLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEV 924 Query: 251 RSLMEQCWSAEPTERPSF---TEVVKRL 177 +M QCW++EP +RPSF +E+V+ L Sbjct: 925 YEIMVQCWNSEPEKRPSFYHLSEIVENL 952
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC 2.7.10.1)| (FGFR-1) Length = 812 Score = 69.3 bits (168), Expect = 9e-12 Identities = 49/158 (31%), Positives = 81/158 (51%), Gaps = 5/158 (3%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSK-VKCQTLISGGVRGTLP--WMAPELL 429 K +H DL + N+LV + I K+ D GL++ + G LP WMAPE L Sbjct: 611 KKCIHRDLAARNVLVT----EDNIMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEAL 666 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+SFG+++WE+ T G PY + + ++ R P +C + Sbjct: 667 --FDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPMEELFK-LLKEGHRMDKPTNCTNEL 723 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRL-RAMATSPTKPLL 141 +M+ CW A P++RP+F ++V+ L R +A S + L Sbjct: 724 YMMMKDCWHAMPSQRPTFNQLVEDLDRILALSSNQEYL 761
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 69.3 bits (168), Expect = 9e-12 Identities = 48/137 (35%), Positives = 69/137 (50%), Gaps = 4/137 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G + + W APE L Sbjct: 380 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 435 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + ++ + P PE C Sbjct: 436 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE-CPESLH 491 Query: 248 SLMEQCWSAEPTERPSF 198 LM QCW +P ERP+F Sbjct: 492 DLMCQCWRKDPEERPTF 508
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 68.9 bits (167), Expect = 1e-11 Identities = 61/182 (33%), Positives = 82/182 (45%), Gaps = 12/182 (6%) Frame = -1 Query: 629 LHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGG 468 LHL +I G K + H DL S N LV R+ + VGD GL++ K G Sbjct: 153 LHLALDIARGLRYLHSKGVFHRDLTSKNCLVR-REDRGFTAVVGDFGLAE-KIPVYREGA 210 Query: 467 ------VRGTLPWMAPELLNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGG 306 V G+ WMAPE+L G L EK DVF+FGIV+ EL+ D G Sbjct: 211 RKEPLAVVGSPYWMAPEVLRGE--LYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFG 268 Query: 305 IVNNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQK*TA 126 + R LV + C + L C + EP+ R FTE+ + L + +P TA Sbjct: 269 LDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLTRTA 328 Query: 125 LS 120 L+ Sbjct: 329 LT 330
>HTK16_HYDAT (P53356) Tyrosine-protein kinase HTK16 (EC 2.7.10.2)| Length = 757 Score = 68.9 bits (167), Expect = 1e-11 Identities = 48/145 (33%), Positives = 70/145 (48%), Gaps = 8/145 (5%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV----KCQTLISGGVRGTLPWMAPEL 432 K VH DL + N+L+ + K+ D GLS+ G R + W APE Sbjct: 602 KRFVHRDLAARNILL----ANKKQVKISDFGLSRAVGTGSDYYQAKQGGRWPVRWYAPES 657 Query: 431 LNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVNNTL----RPLVPESC 264 +N + S K DV+S+GI +WE+ T + DL YG + G V + L R P+ C Sbjct: 658 INYGT--FSTKSDVWSYGITLWEMFT----FGDLPYGEMTGNEVVSFLEHCGRLEKPDEC 711 Query: 263 DPQWRSLMEQCWSAEPTERPSFTEV 189 S+M CW +P +RP+F E+ Sbjct: 712 PIHTYSIMLSCWHIDPNKRPTFNEL 736
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 68.9 bits (167), Expect = 1e-11 Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 5/150 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 VH DL + N+L+N +CKV D GLS+V + G + + W +PE Sbjct: 744 VHRDLAARNILIN----SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPVRWTSPEAT-- 797 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + + DV+S+GIV+WE+++ GE PY ++ +I + PL P C Sbjct: 798 AYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPL-PMDCPAALYQ 856 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSP 156 LM CW + RP F ++V L + +P Sbjct: 857 LMLDCWQKDRNNRPKFEQIVSILDKLIRNP 886
>XMRK_XIPMA (P13388) Melanoma receptor tyrosine-protein kinase precursor (EC| 2.7.10.1) Length = 1167 Score = 68.9 bits (167), Expect = 1e-11 Identities = 52/175 (29%), Positives = 88/175 (50%), Gaps = 10/175 (5%) Frame = -1 Query: 635 WMLHLVWNICTGKN------IVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKC---QT 483 W+L+ I G N +VH DL + N+L L++P K+ D GLSK+ + Sbjct: 811 WLLNWCVQIAKGMNYLEERHLVHRDLAARNVL--LKNPNH--VKITDFGLSKLLTADEKE 866 Query: 482 LISGGVRGTLPWMAPELLNGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGG 306 + G + + WMA E + + + + DV+S+G+ +WEL+T G +PY + I Sbjct: 867 YQADGGKVPIKWMALESILQWT--YTHQSDVWSYGVTVWELMTFGSKPYDGIP-AKEIAS 923 Query: 305 IVNNTLRPLVPESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLL 141 ++ N R P C + ++ +CW +P+ RP F E+V MA P++ L+ Sbjct: 924 VLENGERLPQPPICTIEVYMIILKCWMIDPSSRPRFRELVGEFSQMARDPSRYLV 978
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 68.9 bits (167), Expect = 1e-11 Identities = 44/151 (29%), Positives = 73/151 (48%), Gaps = 5/151 (3%) Frame = -1 Query: 590 VHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQ----TLISGGVRGTLPWMAPELLNG 423 VH DL + N+L+N +CKV D GLS+V + G + + W +PE + Sbjct: 743 VHRDLAARNILIN----SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAI-- 796 Query: 422 SSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWRS 246 + + D +S+GIV+WE+++ GE PY ++ + +I + P P C Sbjct: 797 AYRKFTSASDAWSYGIVLWEVMSYGERPYWEMSFQDVIKAVDEGYRLP-PPMDCPAALYQ 855 Query: 245 LMEQCWSAEPTERPSFTEVVKRLRAMATSPT 153 LM CW + RP F ++V L + +P+ Sbjct: 856 LMLDCWQKDRNNRPKFEQIVSILDKLIRNPS 886
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 68.6 bits (166), Expect = 2e-11 Identities = 48/137 (35%), Positives = 69/137 (50%), Gaps = 4/137 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N VH DL++ N+LV + +CKV D GL+++ + G + + W APE L Sbjct: 380 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 435 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL T G PY + ++ + P PE C Sbjct: 436 GRFTI---KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERAYRMPCPPE-CPESLH 491 Query: 248 SLMEQCWSAEPTERPSF 198 LM QCW +P ERP+F Sbjct: 492 DLMCQCWRKDPEERPTF 508
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 68.6 bits (166), Expect = 2e-11 Identities = 49/156 (31%), Positives = 75/156 (48%), Gaps = 11/156 (7%) Frame = -1 Query: 602 GKNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQTLISGGVRGTLP--WMAPELL 429 GKN +H DL + N LV + K+ D G+S+ + + S +P W APE L Sbjct: 178 GKNCIHRDLAARNCLVG----ENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEAL 233 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLV-------- 276 N S + DV+SFGI++WE + G PY G+ N R V Sbjct: 234 NYGR--YSSESDVWSFGILLWETFSLGVCPYP---------GMTNQQAREQVERGYRMSA 282 Query: 275 PESCDPQWRSLMEQCWSAEPTERPSFTEVVKRLRAM 168 P++C + ++M +CW +P RP F+++ K L A+ Sbjct: 283 PQNCPEEIFTIMMKCWDYKPENRPKFSDLHKELTAI 318
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 68.6 bits (166), Expect = 2e-11 Identities = 51/157 (32%), Positives = 77/157 (49%), Gaps = 4/157 (2%) Frame = -1 Query: 596 NIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKV--KCQTLISGGVRGTLPWMAPEL-LN 426 N +H DL+S N+LV ICK+ D GL+++ + G + + W APE L Sbjct: 384 NYIHRDLRSANILVG----NGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 Query: 425 GSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQWR 249 G + K DV+SFGI++ EL+T G PY ++ ++ + P P+ C Sbjct: 440 GRFTI---KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPC-PQDCPISLH 495 Query: 248 SLMEQCWSAEPTERPSFTEVVKRLRAMATSPTKPLLQ 138 LM CW +P ERP+F + L T+ T+P Q Sbjct: 496 ELMIHCWKKDPEERPTFEYLQSFLEDYFTA-TEPQYQ 531
>SKM1_YEAST (Q12469) Serine/threonine-protein kinase SKM1 (EC 2.7.11.1)| (Protein kinase 75490 D) Length = 655 Score = 68.6 bits (166), Expect = 2e-11 Identities = 55/173 (31%), Positives = 83/173 (47%), Gaps = 14/173 (8%) Frame = -1 Query: 632 MLHLVWNICTG------KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGL------SKVKC 489 M ++V C G K I+H D+KSDN+L+N + + K+ D G + K Sbjct: 484 MAYIVKETCQGLKFLHNKKIIHRDIKSDNILLN----SQGLVKITDFGFCVELTEKRSKR 539 Query: 488 QTLISGGVRGTLPWMAPELLNGSSNLVSEKVDVFSFGIVMWELLTGEEPYADLHYGAIIG 309 T++ GT WMAPE++N EKVDV+S GI++ E++ GE PY + + Sbjct: 540 ATMV-----GTPYWMAPEIVNQKG--YDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALY 592 Query: 308 GIVNNTLRPL-VPESCDPQWRSLMEQCWSAEPTERPSFTEVVK-RLRAMATSP 156 I NN L PES Q + ++ C R S +++ +MA SP Sbjct: 593 LIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLTFEFLSMACSP 645
>VGFR2_HUMAN (P35968) Vascular endothelial growth factor receptor 2 precursor (EC| 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen) Length = 1356 Score = 68.6 bits (166), Expect = 2e-11 Identities = 41/145 (28%), Positives = 75/145 (51%), Gaps = 4/145 (2%) Frame = -1 Query: 599 KNIVHFDLKSDNLLVNLRDPQRPICKVGDLGLSKVKCQT---LISGGVRGTLPWMAPELL 429 + +H DL + N+L++ ++ + K+ D GL++ + + G R L WMAPE + Sbjct: 1022 RKCIHRDLAARNILLS----EKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETI 1077 Query: 428 NGSSNLVSEKVDVFSFGIVMWELLT-GEEPYADLHYGAIIGGIVNNTLRPLVPESCDPQW 252 + + + DV+SFG+++WE+ + G PY + + R P+ P+ Sbjct: 1078 --FDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEM 1135 Query: 251 RSLMEQCWSAEPTERPSFTEVVKRL 177 M CW EP++RP+F+E+V+ L Sbjct: 1136 YQTMLDCWHGEPSQRPTFSELVEHL 1160 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 89,537,065 Number of Sequences: 219361 Number of extensions: 1819216 Number of successful extensions: 8328 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6686 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7205 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5995743495 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
