>PSL2_MOUSE (Q9JJF9) Signal peptide peptidase-like 2A (EC 3.4.23.-) (SPP-like|
           2A protein) (SPPL2a protein) (Intramembrane protease 3)
           (IMP3) (Presenilin-like protein 2)
          Length = 523

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 34/82 (41%), Positives = 47/82 (57%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLWLKGE 358
           Y++ S  AY  G++IT+V L +M   GQPALLY+VP TL T+  + W R E++  W KG 
Sbjct: 439 YYISSTIAYAVGMIITFVVLMVMKT-GQPALLYLVPCTLITVSVVAWSRKEMKKFW-KGS 496

Query: 357 PDRVCTHQGYVQMAKPPPADDE 292
             +V  H  Y    + P   DE
Sbjct: 497 SYQVMGHLDYSTNEENPVTTDE 518

>PSL1_CHICK (Q5F383) Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein|
           SPP-like 2B) (Protein SPPL2b)
          Length = 596

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 40/98 (40%), Positives = 49/98 (50%), Gaps = 9/98 (9%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLWLKG- 361
           YF+    AYG GLL+T+VAL LM   GQPALLY+VP TL T  S+   R EL   W    
Sbjct: 441 YFVACTIAYGIGLLVTFVALALMQ-MGQPALLYLVPCTLITSFSVALWRKELAMFWTGSG 499

Query: 360 ------EPDRVCTHQGYVQMAKPP--PADDEDGEEAKN 271
                 +P  V       Q+ K    PA  ++ EE  N
Sbjct: 500 FAKDLPQPPLVIASVNCPQLPKDSNVPASQQETEEMAN 537

>PSL2_HUMAN (Q8TCT8) Signal peptide peptidase-like 2A (EC 3.4.23.-) (Protein|
           SPP-like 2A) (Protein SPPL2a) (Intramembrane protease 3)
           (IMP3) (Presenilin-like protein 2)
          Length = 520

 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 29/67 (43%), Positives = 42/67 (62%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLWLKGE 358
           Y++ S  AY  G+++T+V L LM   GQPALLY+VP TL T   + W+R E++  W KG 
Sbjct: 436 YYVSSTVAYAIGMILTFVVLVLMK-KGQPALLYLVPCTLITASVVAWRRKEMKKFW-KGN 493

Query: 357 PDRVCTH 337
             ++  H
Sbjct: 494 SYQMMDH 500

>PSL1_HUMAN (Q8TCT7) Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein|
           SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4)
           (IMP4) (Presenilin-like protein 1)
          Length = 592

 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 34/78 (43%), Positives = 43/78 (55%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLWLKGE 358
           YF+    AYG GLL+T+VAL LM   GQPALLY+VP TL T  ++   R EL   W    
Sbjct: 445 YFVACTIAYGVGLLVTFVALALMQ-RGQPALLYLVPCTLVTSCAVALWRRELGVFW---- 499

Query: 357 PDRVCTHQGYVQMAKPPP 304
                T  G+ ++  P P
Sbjct: 500 -----TGSGFAKVLPPSP 512

>PSL1_RAT (Q5PQL3) Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein|
           SPP-like 2B) (Protein SPPL2b)
          Length = 577

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/56 (53%), Positives = 37/56 (66%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLW 370
           YF+    AYG GLL+T+VAL LM  HGQPALLY+VP TL T  ++   R E+   W
Sbjct: 438 YFVACTIAYGLGLLVTFVALVLMR-HGQPALLYLVPCTLLTSCTVALWRREMGAFW 492

>PSL1_MOUSE (Q3TD49) Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein|
           SPP-like 2B) (Protein SPPL2b)
          Length = 578

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 30/56 (53%), Positives = 36/56 (64%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLW 370
           YF+    AYG GLL+T+VAL LM   GQPALLY+VP TL T  ++   R EL   W
Sbjct: 438 YFVACTIAYGLGLLVTFVALVLMQ-RGQPALLYLVPCTLLTSCTVALWRRELGAFW 492

>PSL4_MOUSE (Q9CUS9) Signal peptide peptidase-like 3 (EC 3.4.23.-) (SPP-like 3|
           protein) (Intramembrane protease 2) (IMP2)
           (Presenilin-like protein 4)
          Length = 384

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 24/56 (42%), Positives = 34/56 (60%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLW 370
           YF  +   Y  GLL   VA  +     QPALLY+VPFTL  L+++ + +G+LR +W
Sbjct: 314 YFHCTLIGYFVGLLTATVASRIHRA-AQPALLYLVPFTLLPLLTMAYLKGDLRRMW 368

>PSL4_HUMAN (Q8TCT6) Signal peptide peptidase-like 3 (EC 3.4.23.-) (SPP-like 3|
           protein) (Intramembrane protease 2) (IMP2)
           (Presenilin-like protein 4)
          Length = 385

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 24/56 (42%), Positives = 34/56 (60%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLW 370
           YF  +   Y  GLL   VA  +     QPALLY+VPFTL  L+++ + +G+LR +W
Sbjct: 315 YFHCTLIGYFVGLLTATVASRIHRA-AQPALLYLVPFTLLPLLTMAYLKGDLRRMW 369

>YJ95_CAEEL (P49049) Hypothetical protein T05E11.5 in chromosome IV|
          Length = 468

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 24/56 (42%), Positives = 30/56 (53%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLW 370
           YF+ +  AY  GL IT   ++      QPALLY+VP  L   + L   RGEL  LW
Sbjct: 390 YFVVTVVAYMAGLFITMAVMHHFKA-AQPALLYLVPCCLFVPLLLAVIRGELSALW 444

>HM13_MOUSE (Q9D8V0) Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal|
           peptide peptidase) (Presenilin-like protein 3)
          Length = 378

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 27/87 (31%), Positives = 43/87 (49%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLWLKGE 358
           YF  S +AY  GL +T   +++   H QPALLY+VP  +G  + +   +GE+  ++   E
Sbjct: 290 YFYTSFAAYIFGLGLTIFIMHIFK-HAQPALLYLVPACIGFPVLVALAKGEVAEMFSYEE 348

Query: 357 PDRVCTHQGYVQMAKPPPADDEDGEEA 277
            +            K P A+ E  EE+
Sbjct: 349 SN-----------PKDPAAETESKEES 364

>HM13_HUMAN (Q8TCT9) Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal|
           peptide peptidase) (Presenilin-like protein 3) (hIMP1
           protein)
          Length = 377

 Score = 38.1 bits (87), Expect = 0.017
 Identities = 20/56 (35%), Positives = 33/56 (58%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLW 370
           YF  S +AY  GL +T   +++   H QPALLY+VP  +G  + +   +GE+  ++
Sbjct: 290 YFYTSFAAYIFGLGLTIFIMHIFK-HAQPALLYLVPACIGFPVLVALAKGEVTEMF 344

>YKK0_YEAST (P34248) Hypothetical 67.5 kDa protein in APE1/LAP4-CWP1 intergenic|
           region
          Length = 587

 Score = 32.0 bits (71), Expect = 1.2
 Identities = 18/56 (32%), Positives = 30/56 (53%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLW 370
           YF+ +  +Y   L+   V+L++ +   QPALLYIVP  L + I +     + +  W
Sbjct: 450 YFITAMVSYVASLVSAMVSLSIFNT-AQPALLYIVPSLLISTILVACWNKDFKQFW 504

>CABL1_HUMAN (Q8TDN4) CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1)|
           (Ik3-1)
          Length = 633

 Score = 30.4 bits (67), Expect = 3.5
 Identities = 17/34 (50%), Positives = 19/34 (55%)
 Frame = -1

Query: 424 PGHADLAGVEEGGAAEPVAQGGAGPRVHPSGLRA 323
           P  A+  G EEGGAA+P A G  G R   S L A
Sbjct: 80  PQDAEWGGGEEGGAAKPGAGGACGARTRFSLLAA 113

>LMP1_EBV (P03230) Latent membrane protein 1 (LMP-1) (Protein p63) [Contains:|
           Protein p25]
          Length = 386

 Score = 29.6 bits (65), Expect = 5.9
 Identities = 19/47 (40%), Positives = 24/47 (51%)
 Frame = -2

Query: 501 LLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLWLKG 361
           L+IT + + L + HGQ   L IV F  G L+ LG     L  LW  G
Sbjct: 88  LMITLLLIALWNLHGQALFLGIVLFIFGCLLVLGIWIYLLEMLWRLG 134

>Y173_LACJO (P60927) UPF0078 membrane protein LJ_0173|
          Length = 206

 Score = 29.3 bits (64), Expect = 7.8
 Identities = 16/50 (32%), Positives = 27/50 (54%)
 Frame = -2

Query: 537 YFLWSASAYGTGLLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRG 388
           +F W A      LLI    + +M     P L+Y++ F++ T I+ GW++G
Sbjct: 116 FFDWRAGLIA--LLIGLFLVIIMKNLTIPPLVYMLGFSIFTWINFGWEQG 163

>LMP1_EBVR (P13198) Latent membrane protein 1 (LMP-1) (Protein p63)|
          Length = 386

 Score = 29.3 bits (64), Expect = 7.8
 Identities = 19/47 (40%), Positives = 24/47 (51%)
 Frame = -2

Query: 501 LLITYVALNLMDGHGQPALLYIVPFTLGTLISLGWKRGELRNLWLKG 361
           L+IT + + L + HGQ   L IV F  G L+ LG     L  LW  G
Sbjct: 88  LMITLLLIALWNLHGQALYLGIVLFIFGCLLVLGLWIYLLEILWRLG 134


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,513,348
Number of Sequences: 219361
Number of extensions: 1509886
Number of successful extensions: 4309
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 4109
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4284
length of database: 80,573,946
effective HSP length: 105
effective length of database: 57,541,041
effective search space used: 4488201198
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)