ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | FLbaf8j21 |
|---|---|
| Clone Library Name | barley_pub |
>Q8LFC0:IDH1_ARATH Isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial| precursor - Arabidopsis thaliana (Mouse-ear cress) Length = 367 Score = 588 bits (1516), Expect = e-167 Identities = 295/347 (85%), Positives = 311/347 (89%) Frame = +3 Query: 186 VSRRTVTYMPRPGDGAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS 365 + R+VTYMPRPGDGAPR VTLIPGDGIGPLVT AV QVMEAMHAP+ FE Y+VHG+M Sbjct: 21 IQTRSVTYMPRPGDGAPRAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKYDVHGEMSR 80 Query: 366 VPTEVIESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHEN 545 VP EV+ESIR+NKVCLKGGL TPVGGGVSSLN+QLRKELDL+ASLVNCFNLPGLPTRHEN Sbjct: 81 VPPEVMESIRKNKVCLKGGLKTPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHEN 140 Query: 546 VDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVH 725 VDI VIRENTEGEY+GLEHEVVPGVVESLKV+TKFCSERIAKYAFEYAYLNNRKKVTAVH Sbjct: 141 VDIVVIRENTEGEYAGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVH 200 Query: 726 KANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLV 905 KANIMKLADGLFLESCREVA KYP I YNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLV Sbjct: 201 KANIMKLADGLFLESCREVAKKYPSITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLV 260 Query: 906 SNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLR 1085 +N AAGIA DHAVFEQGASAGNVG DKI+ + KANPVAL LSSAMMLR Sbjct: 261 ANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGNVGKDKIVLENKANPVALLLSSAMMLR 320 Query: 1086 HLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 HLQFPSFADRLE+AVK VIAEGK RT+DLGGTSTTQEV DAVIAKLD Sbjct: 321 HLQFPSFADRLETAVKKVIAEGKCRTKDLGGTSTTQEVVDAVIAKLD 367
>O81796:IDH3_ARATH Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial| precursor - Arabidopsis thaliana (Mouse-ear cress) Length = 368 Score = 574 bits (1480), Expect = e-163 Identities = 286/344 (83%), Positives = 309/344 (89%) Frame = +3 Query: 195 RTVTYMPRPGDGAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPT 374 R++TYMPRPGDGAPRTVTLIPGDGIGPLVTGAV QVMEAMHAPV FE YEV G+M VP Sbjct: 25 RSITYMPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVLGNMRKVPE 84 Query: 375 EVIESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDI 554 EVIES++RNKVCLKGGLATPVGGGVSSLN+QLRKELD++ASLVNC N+PGL TRHENVDI Sbjct: 85 EVIESVKRNKVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDI 144 Query: 555 AVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKAN 734 VIRENTEGEYSGLEHEVVPGVVESLKV+TKFCSERIA+YAFEYAYLNNRKKVTAVHKAN Sbjct: 145 VVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKAN 204 Query: 735 IMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNV 914 IMKLADGLFLESCREVA Y GI YNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL++N Sbjct: 205 IMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANT 264 Query: 915 AAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQ 1094 AAGIA +HA+FEQGASAGNVGNDK+++QKKANPVAL LSSAMMLRHL+ Sbjct: 265 AAGIAGGTGVMPGGNVGAEHAIFEQGASAGNVGNDKMVEQKKANPVALLLSSAMMLRHLR 324 Query: 1095 FPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 FP+FADRLE+AVK VI EGKYRT+DLGG TTQEV DAVIA L+ Sbjct: 325 FPTFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAALE 368
>P93032:IDH2_ARATH Isocitrate dehydrogenase [NAD] regulatory subunit 2, mitochondrial| precursor - Arabidopsis thaliana (Mouse-ear cress) Length = 367 Score = 561 bits (1445), Expect = e-159 Identities = 281/347 (80%), Positives = 303/347 (87%) Frame = +3 Query: 186 VSRRTVTYMPRPGDGAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS 365 + R+VTYMPRPGDG PR VTLIPGDG+GPLVT AV+QVMEAMHAPV FE +EVHGDM S Sbjct: 21 IQTRSVTYMPRPGDGKPRPVTLIPGDGVGPLVTNAVQQVMEAMHAPVYFEPFEVHGDMKS 80 Query: 366 VPTEVIESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHEN 545 +P ++ESI++NKVCLKGGL TPVGGGVSSLN+ LRKELDL+ASLVNCFNLPGL +RHEN Sbjct: 81 LPEGLLESIKKNKVCLKGGLKTPVGGGVSSLNVNLRKELDLFASLVNCFNLPGLASRHEN 140 Query: 546 VDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVH 725 VDI VIRENTEGEY+GLEHEVVPGVVESLKV+TKFCSERIAKYAFEYAYLNNRKKVTAVH Sbjct: 141 VDIVVIRENTEGEYAGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVH 200 Query: 726 KANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLV 905 KANIMKLADGLFLESC+EVA KYP I YNEIIVDNCCMQLVA+PEQFDVMVTPNLYGNLV Sbjct: 201 KANIMKLADGLFLESCQEVAKKYPSIAYNEIIVDNCCMQLVARPEQFDVMVTPNLYGNLV 260 Query: 906 SNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLR 1085 +N AAGIA ++AVFEQGASAGNVG D +QK ANPVAL LSSAMMLR Sbjct: 261 ANTAAGIAGGTGVMPGGNVGAEYAVFEQGASAGNVGKDTTEEQKNANPVALLLSSAMMLR 320 Query: 1086 HLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 HLQFPSFADRLE+AVK VIAEG RT DLGG STTQEV DAVIA LD Sbjct: 321 HLQFPSFADRLETAVKRVIAEGNCRTEDLGGNSTTQEVVDAVIANLD 367
>Q945K7:IDH5_ARATH Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial| precursor - Arabidopsis thaliana (Mouse-ear cress) Length = 374 Score = 322 bits (824), Expect = 3e-87 Identities = 168/331 (50%), Positives = 224/331 (67%), Gaps = 5/331 (1%) Frame = +3 Query: 234 PRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS-----VPTEVIESIRR 398 P T TL PGDGIGP + +V++V P+ +E + V ++ + E +ES+RR Sbjct: 43 PITATLFPGDGIGPEIAESVKKVFTTAGVPIEWEEHYVGTEIDPRTQSFLTWESLESVRR 102 Query: 399 NKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTE 578 NKV LKG +ATP+G G SLNL LRKEL+LYA++ C++LPG TR+++VD+ IRENTE Sbjct: 103 NKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTE 162 Query: 579 GEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGL 758 GEYSGLEH+VV GVVESLK++T+ S R+A+YAF YA + R++V+A+HKANIM+ DGL Sbjct: 163 GEYSGLEHQVVRGVVESLKIITRQASLRVAEYAFLYAKTHGRERVSAIHKANIMQKTDGL 222 Query: 759 FLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXX 938 FL+ CREVA KYP I Y E+++DNCCM LV P FDV+V PNLYG+++S++ AG+ Sbjct: 223 FLKCCREVAEKYPEITYEEVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGL 282 Query: 939 XXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRL 1118 +D A A + I + ANP AL LS MMLRHL+F A+++ Sbjct: 283 GLTPSCNIGEDGVAL---AEAVHGSAPDIAGKNLANPTALLLSGVMMLRHLKFNEQAEQI 339 Query: 1119 ESAVKGVIAEGKYRTRDLGGTSTTQEVTDAV 1211 SA+ IAEGKYRT DLGG+STT E T A+ Sbjct: 340 HSAIINTIAEGKYRTADLGGSSTTTEFTKAI 370
>O13302:IDH1_AJECA Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial precursor -| Ajellomyces capsulata (Histoplasma capsulatum) Length = 388 Score = 315 bits (808), Expect = 2e-85 Identities = 176/340 (51%), Positives = 228/340 (67%), Gaps = 7/340 (2%) Frame = +3 Query: 228 GAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHG------DMPSVPTEVIES 389 G TVTLIPGDGIG V +V+ + +A + P+ +E +V G + E I S Sbjct: 49 GGKYTVTLIPGDGIGTEVAESVKTIFKADNVPIEWEQVDVSGLDAGNKHSEDLFKESIAS 108 Query: 390 IRRNKVCLKGGLATPVG-GGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIR 566 ++RNK+ LKG L TPV G S N+ LR+ELD+YAS+V N+PG TRH+NVD+ +IR Sbjct: 109 LKRNKLGLKGILHTPVERSGHQSFNVALRQELDIYASIVLIKNIPGYKTRHDNVDLCIIR 168 Query: 567 ENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKL 746 ENTEGEYSGLEH+ V GVVESLK++T+ SERIAK+AF +A NNRKKVT +HKANIMKL Sbjct: 169 ENTEGEYSGLEHQSVSGVVESLKIITRAKSERIAKFAFSFALANNRKKVTCIHKANIMKL 228 Query: 747 ADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGI 926 ADGLF + +VA YP ++ N++IVDN MQ VA+P+QFDVMV PNLYG ++SNV A + Sbjct: 229 ADGLFRSTFHKVAESYPTLETNDMIVDNASMQAVARPQQFDVMVMPNLYGGILSNVGAAL 288 Query: 927 AXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSF 1106 +D AVFE G +VG D I + +ANP AL LS +M+LRHL Sbjct: 289 VGGPGIVPGCNMGRDVAVFEPGCR--HVGLD-IKGKDQANPTALILSGSMLLRHLGLDEH 345 Query: 1107 ADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 A+R+ AV VI EG RTRD+GG ++T E T AV+ K++ Sbjct: 346 ANRISKAVYDVIGEGVTRTRDMGGQASTHEFTRAVLDKME 385
>O94229:IDH1_KLULA Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial precursor -| Kluyveromyces lactis (Yeast) (Candida sphaerica) Length = 361 Score = 310 bits (793), Expect = 1e-83 Identities = 170/335 (50%), Positives = 228/335 (68%), Gaps = 3/335 (0%) Frame = +3 Query: 228 GAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHG-DMPSVPTEVIESIRRNK 404 G TVTLIPGDG+G VT +V ++ E + P+ +ET ++ G + +ES++RNK Sbjct: 27 GGRYTVTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISGLENTENVQRAVESLKRNK 86 Query: 405 VCLKGGLATPVGG-GVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEG 581 V LKG TP G SLN+ LRK+LD++A++ ++PG+ TR N+D+ +IRENTEG Sbjct: 87 VGLKGIWHTPADQTGHGSLNVALRKQLDIFANVALFKSIPGVKTRLNNIDMVIIRENTEG 146 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 EYSGLEHE VPGVVESLK+MT+ SERIA++AF++A NNRK V AVHKANIMKL DGLF Sbjct: 147 EYSGLEHESVPGVVESLKIMTRAKSERIARFAFDFALKNNRKSVCAVHKANIMKLGDGLF 206 Query: 762 LESCREV-ATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXX 938 + E+ A +YP + IIVDN MQ VAKP QFDV+VTPNLYG+++ N+ + + Sbjct: 207 RNTVNEIGANEYPELDVKNIIVDNASMQAVAKPHQFDVLVTPNLYGSILGNIGSALIGGP 266 Query: 939 XXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRL 1118 +++AVFE G+ +VG D I Q ANP A+ LSS +MLRHL ++ADR+ Sbjct: 267 GLVPGANFGREYAVFEPGSR--HVGLD-IKGQNVANPTAMILSSTLMLRHLGLNAYADRI 323 Query: 1119 ESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 A VI+EGK TRD+GG+++T E T+AVI KL Sbjct: 324 SKATYDVISEGKSTTRDIGGSASTSEFTNAVIEKL 358
>Q8LG77:IDH6_ARATH Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial| precursor - Arabidopsis thaliana (Mouse-ear cress) Length = 374 Score = 306 bits (784), Expect = 1e-82 Identities = 161/331 (48%), Positives = 218/331 (65%), Gaps = 5/331 (1%) Frame = +3 Query: 234 PRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS-----VPTEVIESIRR 398 P TL PGDGIGP + +V+QV A + ++ V ++ + + ++S+ + Sbjct: 43 PIKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLK 102 Query: 399 NKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTE 578 NKV LKG +ATP+G G SLNL LRKEL+LYA++ C++LPG TR+++VD+ IRENTE Sbjct: 103 NKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTE 162 Query: 579 GEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGL 758 GEYSGLEH+VV GVVESLK++T+ S R+A+YAF YA + RKKV+A+HKANIM+ DGL Sbjct: 163 GEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGL 222 Query: 759 FLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXX 938 FL+ C EVA KYP I Y ++++DNCCM LV P FDV+V PNLYG+++S++ AG+ Sbjct: 223 FLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGL 282 Query: 939 XXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRL 1118 +D A A + I ANP AL LS MMLRHL+ A+++ Sbjct: 283 GLTPSMNIGEDGIAL---AEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQI 339 Query: 1119 ESAVKGVIAEGKYRTRDLGGTSTTQEVTDAV 1211 SA+ IAEGKYRT DLGG+STT + T A+ Sbjct: 340 HSAIINTIAEGKYRTADLGGSSTTTDFTKAI 370
>O13696:IDH1_SCHPO Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial precursor -| Schizosaccharomyces pombe (Fission yeast) Length = 356 Score = 306 bits (783), Expect = 2e-82 Identities = 165/340 (48%), Positives = 229/340 (67%), Gaps = 7/340 (2%) Frame = +3 Query: 228 GAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPT------EVIES 389 G TVTLIPGDGIG + AV ++ + + P+ FE +V G + + E I+S Sbjct: 18 GGKYTVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDVTGMEKNNKSSGDALHEAIQS 77 Query: 390 IRRNKVCLKGGLATPVG-GGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIR 566 ++RNKV LKG L TP GG +S N+ LRKELD+YASLV N+PG TRH+NVD A+IR Sbjct: 78 LKRNKVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGFKTRHDNVDFAIIR 137 Query: 567 ENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKL 746 ENTEGEYSGLEH+ VPGVVESLK++T++ S+RIA++AF++A N RK VT +HKANIMKL Sbjct: 138 ENTEGEYSGLEHQSVPGVVESLKIITEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKL 197 Query: 747 ADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGI 926 ADGLF + +VA Y I ++IVDN MQ V++P+QFDV+V PNLYG+++SN+ + + Sbjct: 198 ADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMPNLYGSILSNIGSAL 257 Query: 927 AXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSF 1106 +D+A+FE G +VG I + +ANP A LS+ +MLRHL + Sbjct: 258 VGGPGVIPGANFGRDYALFEPGCR--HVGL-SITGRGEANPTAAILSACLMLRHLGLKDY 314 Query: 1107 ADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 AD + +A VI EGK T+DLGG+++T + T A++ +++ Sbjct: 315 ADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILERME 354
>Q93714:IDH3A_CAEEL Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial| precursor - Caenorhabditis elegans Length = 358 Score = 300 bits (768), Expect = 1e-80 Identities = 163/347 (46%), Positives = 219/347 (63%), Gaps = 5/347 (1%) Frame = +3 Query: 198 TVTYMPRPGDGAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV-----HGDMP 362 TV R G R VTLIPGDGIGP ++ +V+++ EA AP+ ++ +V + Sbjct: 12 TVGQSIRYSSGDVRRVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRDGVF 71 Query: 363 SVPTEVIESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHE 542 +P+ IE + NKV LKG L TP+G G SLNL +RKE LYA++ C +L G T ++ Sbjct: 72 RIPSRCIELMHANKVGLKGPLETPIGKGHRSLNLAVRKEFSLYANVRPCRSLEGHKTLYD 131 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 NVD+ IRENTEGEYSG+EHE+VPGVV+S+K++T+ S +A +AFEYA N RK VTAV Sbjct: 132 NVDVVTIRENTEGEYSGIEHEIVPGVVQSIKLITETASRNVASFAFEYARQNGRKVVTAV 191 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 HKANIM+ +DGLFL CRE A YP I++ E +D C+ +V P Q+DV+V PNLYG++ Sbjct: 192 HKANIMRQSDGLFLSICREQAALYPDIKFKEAYLDTVCLNMVQDPSQYDVLVMPNLYGDI 251 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMML 1082 +S++ AG+ + AVFE S D I Q KANP AL LS+ MML Sbjct: 252 LSDLCAGLVGGLGVTPSGNIGKGAAVFE---SVHGTAPD-IAGQDKANPTALLLSAVMML 307 Query: 1083 RHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 R++ P A R+E AV IA+G+ +T DLGGT T T V A++ Sbjct: 308 RYMNLPQHAARIEKAVFDAIADGRAKTGDLGGTGTCSSFTADVCARV 354
>P28834:IDH1_YEAST Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial precursor -| Saccharomyces cerevisiae (Baker's yeast) Length = 360 Score = 300 bits (767), Expect = 1e-80 Identities = 169/335 (50%), Positives = 222/335 (66%), Gaps = 3/335 (0%) Frame = +3 Query: 228 GAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV-HGDMPSVPTEVIESIRRNK 404 G TVTLIPGDG+G +T +VR + EA + P+ +ET + D E +ES++RNK Sbjct: 26 GGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVYEAVESLKRNK 85 Query: 405 VCLKGGLATPVGG-GVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEG 581 + LKG TP G SLN+ LRK+LD+YA++ +L G+ TR ++D+ VIRENTEG Sbjct: 86 IGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEG 145 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 E+SGLEHE VPGVVESLKVMT+ +ERIA++AF++A NRK VTAVHKANIMKL DGLF Sbjct: 146 EFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLF 205 Query: 762 LESCREVATK-YPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXX 938 E+ K YP I + IIVDN MQ VAKP QFDV+VTP++YG ++ N+ A + Sbjct: 206 RNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGP 265 Query: 939 XXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRL 1118 +D+AVFE G+ +VG D I Q ANP A+ LSS +ML HL +A R+ Sbjct: 266 GLVAGANFGRDYAVFEPGSR--HVGLD-IKGQNVANPTAMILSSTLMLNHLGLNEYATRI 322 Query: 1119 ESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 AV IAEGK+ TRD+GG+S+T + T+ +I KL Sbjct: 323 SKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357
>Q68FX0:IDH3B_RAT Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor| - Rattus norvegicus (Rat) Length = 385 Score = 295 bits (755), Expect = 3e-79 Identities = 160/337 (47%), Positives = 223/337 (66%), Gaps = 10/337 (2%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPTE-----VIESIRRNKV 407 VT++PGDG+GP + AV++V +A PV F+ + + ++ ++ +E V+ S++ NKV Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHHL-SEVQNMASEEKLEQVLSSMKENKV 109 Query: 408 CLKGGLATPVG--GGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEG 581 + G + TP+ G ++S ++QLR++LDL+A++V+ +LPG TRH N+D+ +IRE TEG Sbjct: 110 AIIGKIYTPMEYKGELASYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEG 169 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 EYS LEHE GV+E LK++T+ S+RIAK+AF+YA R KVTAVHKANIMKL DGLF Sbjct: 170 EYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLF 229 Query: 762 LESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXX 941 L+ C EVA YP I++ +I+DNCCMQLV P QFDV+V PNLYGN++ N+AAG+ Sbjct: 230 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289 Query: 942 XXXXXXXXQDHAVFEQGAS---AGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFAD 1112 ++AVFE GA A VG + ANP A+ LS++ MLRHL + Sbjct: 290 VVPGESYSAEYAVFETGARHPFAQAVG------RNIANPTAMLLSASNMLRHLNLEYHSS 343 Query: 1113 RLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 + AVK VI GK RTRD+GG STT + +VI L Sbjct: 344 MIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>O77784:IDH3B_BOVIN Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor| - Bos taurus (Bovine) Length = 385 Score = 295 bits (755), Expect = 3e-79 Identities = 159/337 (47%), Positives = 225/337 (66%), Gaps = 10/337 (2%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPTE-----VIESIRRNKV 407 VT++PGDG+GP + AV++V +A PV F+ + + ++ ++ +E V+ S++ NKV Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHL-SEVQNMASEEKLEQVLSSMKENKV 109 Query: 408 CLKGGLATPVG--GGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEG 581 + G + TP+ G ++S +++LR++LDL+A++V+ +LPG TRH N+D+ +IRE TEG Sbjct: 110 AIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEG 169 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 EYS LEHE GV+E LK++T+ S+RIAK+AF+YA R KVTAVHKANIMKL DGLF Sbjct: 170 EYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLF 229 Query: 762 LESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXX 941 L+ C EVA YP I++ ++I+DNCCMQLV P QFDV+V PNLYGN++ N+AAG+ Sbjct: 230 LQCCEEVAELYPKIKFEKMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289 Query: 942 XXXXXXXXQDHAVFEQGAS---AGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFAD 1112 ++AVFE GA A VG + ANP A+ LS++ MLRHL ++ Sbjct: 290 VVPGESYSAEYAVFETGARHPFAQAVG------RNIANPTAMLLSASNMLRHLNLEHHSN 343 Query: 1113 RLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 + AVK VI GK RTRD+GG STT + +VI L Sbjct: 344 MIAEAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>Q9VWH4:IDH3A_DROME Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial| precursor - Drosophila melanogaster (Fruit fly) Length = 377 Score = 295 bits (755), Expect = 3e-79 Identities = 155/336 (46%), Positives = 220/336 (65%), Gaps = 7/336 (2%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH-----GDMPSVPTEVIESIRRN 401 + VTLIPGDGIGP ++ AV+++ A + P+ +E +V +P I+S+ N Sbjct: 48 KKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTN 107 Query: 402 KVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEG 581 K+ LKG L TPVG G SLNL LRKE +LYA++ C +L G T +++VD+ IRENTEG Sbjct: 108 KIGLKGPLMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEG 167 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 EYSG+EHE+V GVV+S+K++T+ S+R+A+YAF+YA NNRKKVT VHKANIM+++DGLF Sbjct: 168 EYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLF 227 Query: 762 LESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXX 941 L R++A K+P IQ+ E +D C+ +V P ++DV+V PNLYG+++S++ AG+ Sbjct: 228 LRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLG 287 Query: 942 XXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADR 1115 + A+FE G + G D ANP AL LS+ MMLRH++ ++AD+ Sbjct: 288 LTPSGNMGLNGALFESVHGTAPDIAGKD------LANPTALLLSAVMMLRHMELNTYADK 341 Query: 1116 LESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 +E A I EGKY T DLGG + E T+ + AKL Sbjct: 342 IERAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL 377
>Q93353:IDH3B_CAEEL Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial| precursor - Caenorhabditis elegans Length = 379 Score = 295 bits (754), Expect = 4e-79 Identities = 166/357 (46%), Positives = 222/357 (62%), Gaps = 11/357 (3%) Frame = +3 Query: 183 AVSRRTVTYMPRPGDGAPRT--VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETY---EV 347 A SR+ PRP + VT+IPGDG+GP + V+ +++ P+ FE EV Sbjct: 23 ASSRQYSITAPRPPTELNQKLKVTIIPGDGVGPELIYTVQDIVKQTGIPIEFEEIFLSEV 82 Query: 348 HGDMPSVPTEVIESI-RRNKVCLKGGLATPV----GGGVSSLNLQLRKELDLYASLVNCF 512 H S +ESI R N V LKG + G + LN++LR+ LDL+A++V+ Sbjct: 83 HYTRSSSIENAVESIGRNNNVALKGAIEESAVLHTEGELQGLNMRLRRSLDLFANVVHIK 142 Query: 513 NLPGLPTRH-ENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYA 689 L G+ TRH + +D ++RE TEGEYS LEHE+VPGV+E LK+ T+ +ERIAK+AF+YA Sbjct: 143 TLDGIKTRHGKQLDFVIVREQTEGEYSSLEHELVPGVIECLKISTRTKAERIAKFAFDYA 202 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD 869 RKKVTAVHKANIMKL DGLFL +C VA +YP IQ+ +I+DN CMQLV+KPEQFD Sbjct: 203 TKTGRKKVTAVHKANIMKLGDGLFLRTCEGVAKQYPKIQFESMIIDNTCMQLVSKPEQFD 262 Query: 870 VMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANP 1049 VMV PNLYGN++ N+AAG+ +D +FE G+ + + + ANP Sbjct: 263 VMVMPNLYGNIIDNLAAGLVGGAGVVPGQSVGRDFVIFEPGS---RHSFQEAMGRSIANP 319 Query: 1050 VALFLSSAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAK 1220 A+ L +A ML HL ++ + L AV V+ EGK RTRDLGG +TT + DAVI K Sbjct: 320 TAMILCAANMLNHLHLDAWGNSLRQAVADVVKEGKVRTRDLGGYATTVDFADAVIDK 376
>Q28479:IDH3B_MACFA Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor| - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) Length = 385 Score = 294 bits (752), Expect = 7e-79 Identities = 159/337 (47%), Positives = 224/337 (66%), Gaps = 10/337 (2%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPTE-----VIESIRRNKV 407 VT++PGDG+GP + AV++V +A PV F+ + + ++ ++ +E V+ S++ NKV Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHL-SEVQNMASEEKLEQVLSSMKENKV 109 Query: 408 CLKGGLATPVG--GGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEG 581 + G + TP+ G ++S +++LR++LDL+A++V+ +LPG TRH N+D+ +IRE TEG Sbjct: 110 AIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEG 169 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 EYS LEHE GV+E LK++T+ S+RIAK+AF+YA R KVTAVHKANIMKL DGLF Sbjct: 170 EYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLF 229 Query: 762 LESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXX 941 L+ C EVA YP I++ +I+DNCCMQLV P QFDV+V PNLYGN++ N+AAG+ Sbjct: 230 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289 Query: 942 XXXXXXXXQDHAVFEQGAS---AGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFAD 1112 ++AVFE GA A VG + ANP A+ LS++ MLRHL ++ Sbjct: 290 VVPGESYSAEYAVFETGARHPFAQAVG------RNIANPTAMLLSASNMLRHLNLEYHSN 343 Query: 1113 RLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 + AVK VI GK RTRD+GG STT + +VI L Sbjct: 344 MIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>O43837:IDH3B_HUMAN Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor| - Homo sapiens (Human) Length = 385 Score = 293 bits (749), Expect = 2e-78 Identities = 159/337 (47%), Positives = 223/337 (66%), Gaps = 10/337 (2%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPTE-----VIESIRRNKV 407 VT++PGDG+GP + AV++V +A PV F+ + + ++ ++ +E V+ S++ NKV Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHL-SEVQNMASEEKLEQVLSSMKENKV 109 Query: 408 CLKGGLATPVG--GGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEG 581 + G + TP+ G ++S +++LR++LDL+A++V+ +LPG TRH N+D+ +IRE TEG Sbjct: 110 AIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEG 169 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 EYS LEHE GV+E LK++T+ S+RIAK+AF+YA R KVTAVHKANIMKL DGLF Sbjct: 170 EYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLF 229 Query: 762 LESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXX 941 L+ C EVA YP I++ +I+DNCCMQLV P QFDV+V PNLYGN++ N+AAG+ Sbjct: 230 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289 Query: 942 XXXXXXXXQDHAVFEQGAS---AGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFAD 1112 ++AVFE GA A VG + ANP A+ LS++ MLRHL + Sbjct: 290 VVPGESYSAEYAVFETGARHPFAQAVG------RNIANPTAMLLSASNMLRHLNLEYHSS 343 Query: 1113 RLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 + AVK VI GK RTRD+GG STT + +VI L Sbjct: 344 MIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>P29696:LEU3_SOLTU 3-isopropylmalate dehydrogenase, chloroplast precursor - Solanum| tuberosum (Potato) Length = 357 Score = 289 bits (740), Expect = 2e-77 Identities = 151/308 (49%), Positives = 206/308 (66%), Gaps = 5/308 (1%) Frame = +3 Query: 246 TLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS-----VPTEVIESIRRNKVC 410 TL PGDGIGP + +VRQ+ + P+ +E + V ++ + E +ES+RRNKV Sbjct: 40 TLFPGDGIGPEIAESVRQIFKVAEVPIEWEEHYVGTEVDPRTNSFLTWESLESVRRNKVG 99 Query: 411 LKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEGEYS 590 LKG +ATP+G G SLNL LRKEL+LYA++ C++LPG TR+++V++ IRENTEGEYS Sbjct: 100 LKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVNLITIRENTEGEYS 159 Query: 591 GLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLES 770 GLEH+VV GVVESLK++T+ S R+A+YAF YA + R++V+A+HKANIM+ DGLFL+ Sbjct: 160 GLEHQVVRGVVESLKIITRQASLRVAEYAFHYAKTHGRERVSAIHKANIMQKTDGLFLKC 219 Query: 771 CREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXXXXX 950 CREVA KYP I+Y E+++DNCCM LV P FDV+V PNLYG+++S++ AG+ Sbjct: 220 CREVAEKYPEIKYEEVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTP 279 Query: 951 XXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRLESAV 1130 + A A + I + ANP AL LSS MLRHL+ ADR++ A+ Sbjct: 280 SCNIGEGGIAL---AEAVHGSAPDIAGKNLANPTALLLSSVSMLRHLELHDKADRIQDAI 336 Query: 1131 KGVIAEGK 1154 IA GK Sbjct: 337 LKTIAGGK 344
>Q5RBT4:IDH3B_PONPY Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor| - Pongo pygmaeus (Orangutan) Length = 385 Score = 288 bits (736), Expect = 5e-77 Identities = 157/337 (46%), Positives = 221/337 (65%), Gaps = 10/337 (2%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPTE-----VIESIRRNKV 407 VT++PGDG+GP + AV++V +A PV F+ + + ++ ++ +E V+ S++ NKV Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHL-SEVQNMASEEKLEQVLSSMKENKV 109 Query: 408 CLKGGLATPVG--GGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEG 581 + G + TP+ G ++S +++LR++LDL+A++V+ +LPG TRH N+D+ +IRE TEG Sbjct: 110 AIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEG 169 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 E S LEHE GV+E LK++T+ S+RIAK+AF+YA R KV AVHKANIMKL DGLF Sbjct: 170 ECSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRSKVIAVHKANIMKLGDGLF 229 Query: 762 LESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXX 941 L+ C EVA YP I++ +I+DNCCMQLV P QFDV+V PNLYGN++ N+AAG+ Sbjct: 230 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289 Query: 942 XXXXXXXXQDHAVFEQGAS---AGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFAD 1112 ++AVFE GA A VG + ANP A+ LS++ MLRHL + Sbjct: 290 VVPGESYSAEYAVFETGARHPFAQAVG------RNIANPTAMLLSASNMLRHLNLEYHSS 343 Query: 1113 RLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 + AVK VI GK RTRD+GG STT + +VI L Sbjct: 344 MIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>P51553:IDH3G_HUMAN Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor| - Homo sapiens (Human) Length = 393 Score = 286 bits (731), Expect = 2e-76 Identities = 167/342 (48%), Positives = 212/342 (61%), Gaps = 5/342 (1%) Frame = +3 Query: 204 TYMPRPGDGAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPTEV- 380 T P G TVT+IPGDGIGP + V+ V PV FE EVH + ++ Sbjct: 44 TIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE--EVHVSSNADEEDIR 101 Query: 381 --IESIRRNKVCLKGGLATP--VGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENV 548 I +IRRN+V LKG + T + S N LR LDLYA++++C +LPG+ TRH+++ Sbjct: 102 NAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDI 161 Query: 549 DIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHK 728 DI ++RENTEGEYS LEHE V GVVESLK++TK S RIA+YAF+ A + RKKVTAVHK Sbjct: 162 DILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHK 221 Query: 729 ANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVS 908 ANIMKL DGLFL+ CREVA +YP I + +IVDN MQLV++P+QFDVMV PNLYGN+V+ Sbjct: 222 ANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVN 281 Query: 909 NVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRH 1088 NV AG+ +AVFE + N G I + ANP A L+S MML H Sbjct: 282 NVCAGLVGGPGLVAGANYGHVYAVFE--TATRNTGK-SIANKNIANPTATLLASCMMLDH 338 Query: 1089 LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVI 1214 L+ S+A + AV + T D+GG TT E VI Sbjct: 339 LKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVI 380
>Q58CP0:IDH3G_BOVIN Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor| - Bos taurus (Bovine) Length = 392 Score = 286 bits (731), Expect = 2e-76 Identities = 166/342 (48%), Positives = 211/342 (61%), Gaps = 5/342 (1%) Frame = +3 Query: 204 TYMPRPGDGAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPTEV- 380 T P G TVT+IPGDGIGP + V+ V PV FE EVH + ++ Sbjct: 43 TIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE--EVHVSSTADEEDIR 100 Query: 381 --IESIRRNKVCLKGGLATP--VGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENV 548 I +IRRN+V LKG + T + S N LR LDLYA++++C +LPG+ TRH ++ Sbjct: 101 NAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHRDI 160 Query: 549 DIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHK 728 DI ++RENTEGEYS LEHE V GVVESLK++TK S RIA+YAF+ A + RKKVTAVHK Sbjct: 161 DILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFQLAQESGRKKVTAVHK 220 Query: 729 ANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVS 908 ANIMKL DGLFL+ CREVA +YP I + +IVDN MQLV++P+QFDVMV PNLYGN+V+ Sbjct: 221 ANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVN 280 Query: 909 NVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRH 1088 NV AG+ +AVFE + N G I + ANP A L+S MML H Sbjct: 281 NVCAGLVGGPGLVAGANYGHVYAVFE--TATRNTGK-SIANKNIANPTATLLASCMMLDH 337 Query: 1089 LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVI 1214 L+ S+A + AV + T D+GG TT E +I Sbjct: 338 LKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDII 379
>P41564:IDH3G_MACFA Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor| - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) Length = 355 Score = 285 bits (730), Expect = 3e-76 Identities = 166/342 (48%), Positives = 212/342 (61%), Gaps = 5/342 (1%) Frame = +3 Query: 204 TYMPRPGDGAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPTEV- 380 T P G TVT+IPGDGIGP + V+ V PV FE EVH + ++ Sbjct: 6 TIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE--EVHVSSNADEEDIR 63 Query: 381 --IESIRRNKVCLKGGLATP--VGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENV 548 I +IRRN+V LKG + T + S N LR LDLYA++++C +LPG+ TRH+++ Sbjct: 64 NAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDI 123 Query: 549 DIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHK 728 DI ++RENTEGEYS LEHE V GVVESLK++TK S RIA+YAF+ A + RKKVTAVHK Sbjct: 124 DILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHK 183 Query: 729 ANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVS 908 ANIMKL DGLFL+ CREVA +YP I + +IVDN MQLV++P+QFDVMV PNLYGN+V+ Sbjct: 184 ANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVN 243 Query: 909 NVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRH 1088 NV AG+ +AVFE + N G I + ANP A L+S MML H Sbjct: 244 NVCAGLVGGPGLVAGANYGHVYAVFE--TATRNTGK-SIANKNIANPTATLLASCMMLDH 300 Query: 1089 LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVI 1214 L+ S+A + AV + T D+GG TT E +I Sbjct: 301 LKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDII 342
>P41565:IDH3G_RAT Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor| - Rattus norvegicus (Rat) Length = 393 Score = 285 bits (729), Expect = 3e-76 Identities = 165/342 (48%), Positives = 213/342 (62%), Gaps = 5/342 (1%) Frame = +3 Query: 204 TYMPRPGDGAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPTEV- 380 T P G TVT+IPGDGIGP + V+ V PV FE EVH + ++ Sbjct: 44 TIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE--EVHVSSNADEEDIR 101 Query: 381 --IESIRRNKVCLKGGLAT--PVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENV 548 I +IRRN+V LKG + T + S N LR LDLYA++++C +LPG+ TRH+++ Sbjct: 102 NAIMAIRRNRVALKGNIETNHDLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDI 161 Query: 549 DIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHK 728 DI ++RENTEGEYS LEHE V GVVESLK++TK S RIA+YAF+ A + RKKVTAVHK Sbjct: 162 DILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHK 221 Query: 729 ANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVS 908 ANIMKL DGLFL+ CREVA +YP I ++ +IVDN MQLV++P+QFDVMV PNLYGN+V+ Sbjct: 222 ANIMKLGDGLFLQCCREVAARYPQITFDSMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVN 281 Query: 909 NVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRH 1088 NV AG+ +AVFE + N G I + ANP A L+S MML H Sbjct: 282 NVCAGLVGGPGLVAGANYGHVYAVFE--TATRNTGK-SIANKNIANPTATLLASCMMLDH 338 Query: 1089 LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVI 1214 L+ S+A + AV + T D+GG TT + +I Sbjct: 339 LKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSQAIQDII 380
>P70404:IDH3G_MOUSE Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor| - Mus musculus (Mouse) Length = 393 Score = 283 bits (725), Expect = 1e-75 Identities = 165/342 (48%), Positives = 212/342 (61%), Gaps = 5/342 (1%) Frame = +3 Query: 204 TYMPRPGDGAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPTEV- 380 T P G TVT+IPGDGIGP + V+ V PV FE EVH + ++ Sbjct: 44 TIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE--EVHVSSNADEEDIR 101 Query: 381 --IESIRRNKVCLKGGLATP--VGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENV 548 I +IRRN+V LKG + T + S N LR LDLYA++++C +LPG+ TRH+++ Sbjct: 102 NAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDI 161 Query: 549 DIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHK 728 DI ++RENTEGEYS LEHE V GVVESLK++TK S RIA+YAF+ A + RKKVTAVHK Sbjct: 162 DILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHK 221 Query: 729 ANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVS 908 ANIMKL DGLFL+ CREVA YP I ++ +IVDN MQLV++P+QFDVMV PNLYGN+V+ Sbjct: 222 ANIMKLGDGLFLQCCREVAAHYPQITFDSMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVN 281 Query: 909 NVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRH 1088 NV AG+ +AVFE + N G I + ANP A L+S MML H Sbjct: 282 NVCAGLVGGPGLVAGANYGHVYAVFE--TATRNTGK-SIANKNIANPTATLLASCMMLDH 338 Query: 1089 LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVI 1214 L+ S+A + AV + T D+GG TT + +I Sbjct: 339 LKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSQAIQDII 380
>Q9LQK9:IDH4_ARATH Putative isocitrate dehydrogenase [NAD] subunit-like 4 - Arabidopsis| thaliana (Mouse-ear cress) Length = 294 Score = 281 bits (719), Expect = 5e-75 Identities = 177/336 (52%), Positives = 213/336 (63%), Gaps = 5/336 (1%) Frame = +3 Query: 234 PRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHG-DMPSVPTEVIESIRRNKVC 410 PR VT+I + VT AV QVM+AM APV FETY + G +M + EV++SIR+NKVC Sbjct: 2 PRPVTVIDSN-----VTNAVHQVMDAMQAPVYFETYIIKGKNMNHLTWEVVDSIRKNKVC 56 Query: 411 LKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEGEYS 590 L G + + GG RKELDL+ASLV+CFNL G P+RHENVDI VIRENTEGEY+ Sbjct: 57 LNGRVNNSLCGGA-------RKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYA 109 Query: 591 GLEHEVVPGVVESLKV-MTKFCSERIAKYAFEYAYLNNRKKVTAVH-KANIMKLADGLFL 764 G EHEVVPGV+ES +V MTKF S+RIAKYAFEYA+ + RKKVTAVH KLAD FL Sbjct: 110 GREHEVVPGVIESFQVTMTKFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKLADAFFL 169 Query: 765 ESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG--NLVSNVAAGIAXXX 938 ESC+EVA YP I YNEI A E + N +++N+A+G+A Sbjct: 170 ESCQEVAKMYPNITYNEI----------ASRETRAIRRHSNSKSLWAIIANIASGVA--- 216 Query: 939 XXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRL 1118 D+A+FEQ G+VGN K NPVAL SS MMLRHL P FADRL Sbjct: 217 ----GGSFGDDYAIFEQ---VGSVGNHK-------NPVALLFSSVMMLRHLLLPLFADRL 262 Query: 1119 ESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 ++AV VI+EGK +TTQEV D+VIA LD Sbjct: 263 KTAVTRVISEGKCG----NSNTTTQEVVDSVIANLD 294
>P41563:IDH3A_BOVIN Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor| - Bos taurus (Bovine) Length = 366 Score = 279 bits (713), Expect = 2e-74 Identities = 152/340 (44%), Positives = 214/340 (62%), Gaps = 8/340 (2%) Frame = +3 Query: 228 GAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH-----GDMPSVPTEVIESI 392 G +TVTLIPGDGIGP ++ AV ++ +A AP+ +E V G +P E ES+ Sbjct: 29 GGVKTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVAAIQGPGGKWMIPPEAKESM 88 Query: 393 RRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIREN 572 +NK+ LKG L TP+ G S+NL LRK DLYA++ C ++ G T + +V+I IREN Sbjct: 89 DKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYHDVNIVTIREN 148 Query: 573 TEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLAD 752 TEGEYSG+EH +V GVV+S+K++T+ S+RIA++AFEYA N+R VTAVHKANIM+++D Sbjct: 149 TEGEYSGIEHVIVDGVVQSIKLITEAASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSD 208 Query: 753 GLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAG-IA 929 GLFL+ CREVA I++NE+ +D C+ +V P QFDV+V PNLYG+++S++ AG I Sbjct: 209 GLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIG 268 Query: 930 XXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 A+FE G + G D ANP AL LS+ MMLRH+ Sbjct: 269 GLGVTPSGNIGANGVAIFESVHGTAPDIAGKD------MANPTALLLSAVMMLRHMGLFD 322 Query: 1104 FADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 A ++E+A I +GK T+DLGG S + T+ + ++ Sbjct: 323 HAAKIETACFATIKDGKSLTKDLGGNSKCSDFTEEICRRV 362
>Q5R678:IDH3A_PONPY Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor| - Pongo pygmaeus (Orangutan) Length = 366 Score = 278 bits (712), Expect = 3e-74 Identities = 152/340 (44%), Positives = 215/340 (63%), Gaps = 8/340 (2%) Frame = +3 Query: 228 GAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH-----GDMPSVPTEVIESI 392 G +TVTLIPGDGIGP ++ AV ++ +A AP+ +E V G +P+E ES+ Sbjct: 29 GGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESM 88 Query: 393 RRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIREN 572 +NK+ LKG L TP+ G S+NL LRK DLYA++ C ++ G T + +V+I IREN Sbjct: 89 DKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIREN 148 Query: 573 TEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLAD 752 TEGEYSG+EH +V GVV+S+K++T+ S+RIA++AFEYA N+R VTAVHKANIM+++D Sbjct: 149 TEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSD 208 Query: 753 GLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAG-IA 929 GLFL+ CREVA I++NE+ +D C+ +V P QFDV+V PNLYG+++S++ AG I Sbjct: 209 GLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIG 268 Query: 930 XXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 A+FE G + G D ANP AL LS+ MMLRH+ Sbjct: 269 GLGVTPSGNIGANGVAIFESVHGTAPDIAGKD------MANPTALLLSAVMMLRHMGLFD 322 Query: 1104 FADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 A R+E+A I +GK T+DLGG + + T+ + ++ Sbjct: 323 HAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRV 362
>P50213:IDH3A_HUMAN Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor| - Homo sapiens (Human) Length = 366 Score = 278 bits (712), Expect = 3e-74 Identities = 152/340 (44%), Positives = 215/340 (63%), Gaps = 8/340 (2%) Frame = +3 Query: 228 GAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH-----GDMPSVPTEVIESI 392 G +TVTLIPGDGIGP ++ AV ++ +A AP+ +E V G +P+E ES+ Sbjct: 29 GGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESM 88 Query: 393 RRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIREN 572 +NK+ LKG L TP+ G S+NL LRK DLYA++ C ++ G T + +V+I IREN Sbjct: 89 DKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIREN 148 Query: 573 TEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLAD 752 TEGEYSG+EH +V GVV+S+K++T+ S+RIA++AFEYA N+R VTAVHKANIM+++D Sbjct: 149 TEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSD 208 Query: 753 GLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAG-IA 929 GLFL+ CREVA I++NE+ +D C+ +V P QFDV+V PNLYG+++S++ AG I Sbjct: 209 GLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIG 268 Query: 930 XXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 A+FE G + G D ANP AL LS+ MMLRH+ Sbjct: 269 GLGVTPSGNIGANGVAIFESVHGTAPDIAGKD------MANPTALLLSAVMMLRHMGLFD 322 Query: 1104 FADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 A R+E+A I +GK T+DLGG + + T+ + ++ Sbjct: 323 HAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRV 362
>Q28480:IDH3A_MACFA Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor| - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) Length = 347 Score = 277 bits (709), Expect = 7e-74 Identities = 152/340 (44%), Positives = 215/340 (63%), Gaps = 8/340 (2%) Frame = +3 Query: 228 GAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH-----GDMPSVPTEVIESI 392 G +TVTLIPGDGIGP ++ AV ++ +A AP+ +E V G +P+E ES+ Sbjct: 10 GGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESM 69 Query: 393 RRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIREN 572 +NK+ LKG L TP+ G S+NL LRK DLYA++ C ++ G T + +V+I IREN Sbjct: 70 DKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIREN 129 Query: 573 TEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLAD 752 TEGEYSG+EH +V GVV+S+K++T+ S+RIA++AFEYA N+R VTAVHKANIM+++D Sbjct: 130 TEGEYSGIEHVIVDGVVQSIKLITEGGSKRIAEFAFEYARNNHRSNVTAVHKANIMRMSD 189 Query: 753 GLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAG-IA 929 GLFL+ CREVA I++NE+ +D C+ +V P QFDV+V PNLYG+++S++ AG I Sbjct: 190 GLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIG 249 Query: 930 XXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 A+FE G + G D ANP AL LS+ MMLRH+ Sbjct: 250 GLGVTPSGNIGANGVAIFESVHGTAPDIAGKD------MANPTALLLSAVMMLRHMGLFD 303 Query: 1104 FADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 A R+E+A I +GK T+DLGG + + T+ + ++ Sbjct: 304 HAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRV 343
>Q9USP8:IDH2_SCHPO Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial precursor -| Schizosaccharomyces pombe (Fission yeast) Length = 378 Score = 277 bits (709), Expect = 7e-74 Identities = 147/335 (43%), Positives = 217/335 (64%), Gaps = 7/335 (2%) Frame = +3 Query: 240 TVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH----GDMPSVPTEVIESIRRNKV 407 TVT+I GDGIGP + +V ++ +A P+ +E +V+ ++P + ES+R+NKV Sbjct: 47 TVTMIAGDGIGPEIAQSVERIFKAAKVPIEWERVKVYPILKNGTTTIPDDAKESVRKNKV 106 Query: 408 CLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEGEY 587 LKG LATP+G G S+NL LR+ L+A++ C ++ G T ++NV+ +IRENTEGEY Sbjct: 107 ALKGPLATPIGKGHVSMNLTLRRTFGLFANVRPCVSITGYKTPYDNVNTVLIRENTEGEY 166 Query: 588 SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLE 767 SG+EHEV+PGVV+S+K++T+ SER+ +YAF+YA + +T VHKA IM++ADGLFLE Sbjct: 167 SGIEHEVIPGVVQSIKLITRAASERVIRYAFQYARQTGKNNITVVHKATIMRMADGLFLE 226 Query: 768 SCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD--VMVTPNLYGNLVSNVAAGIAXXXX 941 +E+A +YP I+ E I+DN C+++V P ++ VMV PNLYG++VS++ AG+ Sbjct: 227 CAKELAPEYPDIELREEILDNACLKIVTDPVPYNNTVMVMPNLYGDIVSDMCAGLIGGLG 286 Query: 942 XXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRLE 1121 ++FE A G + I + ANP AL LSS MML+H+ +A R+E Sbjct: 287 LTPSGNIGNQASIFE--AVHGTAPD--IAGKGLANPTALLLSSVMMLKHMNLNDYAKRIE 342 Query: 1122 SAVKGVIAEG-KYRTRDLGGTSTTQEVTDAVIAKL 1223 SA+ +A RT+DLGG S + TDA+I+KL Sbjct: 343 SAIFDTLANNPDARTKDLGGKSNNVQYTDAIISKL 377
>Q99NA5:IDH3A_RAT Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor| - Rattus norvegicus (Rat) Length = 366 Score = 276 bits (707), Expect = 1e-73 Identities = 151/340 (44%), Positives = 214/340 (62%), Gaps = 8/340 (2%) Frame = +3 Query: 228 GAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH-----GDMPSVPTEVIESI 392 G +TVTLIPGDGIGP ++ +V ++ +A AP+ +E V G +P E ES+ Sbjct: 29 GGVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPPEAKESM 88 Query: 393 RRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIREN 572 +NK+ LKG L TP+ G S+NL LRK DLYA++ C ++ G T + +V+I IREN Sbjct: 89 DKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIREN 148 Query: 573 TEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLAD 752 TEGEYSG+EH +V GVV+S+K++T+ S+RIA++AFEYA N+R VTAVHKANIM+++D Sbjct: 149 TEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSD 208 Query: 753 GLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAG-IA 929 GLFL+ CREVA I++NE+ +D C+ +V P QFDV+V PNLYG+++S++ AG I Sbjct: 209 GLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIG 268 Query: 930 XXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 A+FE G + G D ANP AL LS+ MMLRH+ Sbjct: 269 GLGVTQSGNIGANGVAIFESVHGTAPDIAGKD------MANPTALLLSAVMMLRHMGLFD 322 Query: 1104 FADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 A ++E+A I +GK T+DLGG S + T+ + ++ Sbjct: 323 HAAKIEAACFATIKDGKSLTKDLGGNSKCSDFTEEICRRV 362
>Q9D6R2:IDH3A_MOUSE Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor| - Mus musculus (Mouse) Length = 366 Score = 275 bits (704), Expect = 3e-73 Identities = 150/340 (44%), Positives = 214/340 (62%), Gaps = 8/340 (2%) Frame = +3 Query: 228 GAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH-----GDMPSVPTEVIESI 392 G +TVTLIPGDGIGP ++ +V ++ +A AP+ +E V G +P E ES+ Sbjct: 29 GGVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPPEAKESM 88 Query: 393 RRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIREN 572 +NK+ LKG L TP+ G S+NL LRK DLYA++ C ++ G T + +V+I IREN Sbjct: 89 DKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIREN 148 Query: 573 TEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLAD 752 TEGEYSG+EH +V GVV+S+K++T+ S+RIA++AFEYA N+R VTAVHKANIM+++D Sbjct: 149 TEGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSD 208 Query: 753 GLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAG-IA 929 GLFL+ CREVA I++NE+ +D C+ +V P QFDV+V PNLYG+++S++ AG I Sbjct: 209 GLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIG 268 Query: 930 XXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 A+FE G + G D ANP AL LS+ MMLRH+ Sbjct: 269 GLGVTPSGNIGANGVAIFESVHGTAPDIAGKD------MANPTALLLSAVMMLRHMGLFD 322 Query: 1104 FADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 A ++E+A I +GK T+DLGG + + T+ + ++ Sbjct: 323 HAAKIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRV 362
>O94230:IDH2_KLULA Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial precursor -| Kluyveromyces lactis (Yeast) (Candida sphaerica) Length = 368 Score = 255 bits (652), Expect = 3e-67 Identities = 145/348 (41%), Positives = 216/348 (62%), Gaps = 8/348 (2%) Frame = +3 Query: 204 TYMPRPGDGAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH----GDMPSVP 371 T P P G TV+ I GDG+GP ++ +V+ + A P+ +E+ +V + ++P Sbjct: 26 TGKPNPKTGK-YTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIFVNGLTTIP 84 Query: 372 TEVIESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVD 551 + SI +N + LKG LATP+G G SLNL LRK L+A++ ++ G T +ENV+ Sbjct: 85 DPAVASINKNLIALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVN 144 Query: 552 IAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKA 731 + +IRENTEGEYSG+EH V PGVV+S+K++T+ SER+ +YAFEYA +R KV VHK+ Sbjct: 145 LVLIRENTEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKS 204 Query: 732 NIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD--VMVTPNLYGNLV 905 I +LADGLF++ ++++++YP I+ ++DN ++ V PE +D V+V PNLYG+++ Sbjct: 205 TIQRLADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIL 264 Query: 906 SNVAAGI-AXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMML 1082 S++ +G+ A ++FE A + I Q KANP AL LSS MML Sbjct: 265 SDLNSGLSAGSLGLTPSANIGHTVSIFE----AVHGSAPDIAGQNKANPTALLLSSVMML 320 Query: 1083 RHLQFPSFADRLESAVKGVIA-EGKYRTRDLGGTSTTQEVTDAVIAKL 1223 H+ AD++E AV IA + K RT DLGG+++T TDAVI +L Sbjct: 321 NHMGLTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
>P28241:IDH2_YEAST Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial precursor -| Saccharomyces cerevisiae (Baker's yeast) Length = 369 Score = 253 bits (646), Expect = 1e-66 Identities = 144/348 (41%), Positives = 214/348 (61%), Gaps = 8/348 (2%) Frame = +3 Query: 204 TYMPRPGDGAPRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH----GDMPSVP 371 T P P G TV+ I GDGIGP ++ +V+++ A + P+ +E+ +V + ++P Sbjct: 27 TGKPNPSTGK-YTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIP 85 Query: 372 TEVIESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVD 551 ++SI +N V LKG LATP+G G SLNL LRK L+A++ ++ G T +ENVD Sbjct: 86 DPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVD 145 Query: 552 IAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKA 731 + +IRENTEGEYSG+EH V PGVV+S+K++T+ SER+ +YAFEYA R +V VHK+ Sbjct: 146 LVLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKS 205 Query: 732 NIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD--VMVTPNLYGNLV 905 I +LADGLF+ +E++ +YP + ++DN +++V P + V V PNLYG+++ Sbjct: 206 TIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDIL 265 Query: 906 SNVAAGI-AXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMML 1082 S++ +G+ A ++FE A + I Q KANP AL LSS MML Sbjct: 266 SDLNSGLSAGSLGLTPSANIGHKISIFE----AVHGSAPDIAGQDKANPTALLLSSVMML 321 Query: 1083 RHLQFPSFADRLESAVKGVIAEG-KYRTRDLGGTSTTQEVTDAVIAKL 1223 H+ + AD++++AV IA G + RT DL GT+TT T+AVI +L Sbjct: 322 NHMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL 369
>P33197:IDH_THET8 Isocitrate dehydrogenase [NADP] - Thermus thermophilus (strain HB8 /| ATCC 27634 / DSM 579) Length = 496 Score = 223 bits (568), Expect = 2e-57 Identities = 135/346 (39%), Positives = 199/346 (57%), Gaps = 13/346 (3%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV------HGDMPSVPTEVIESIRR 398 + +T+IPGDGIGP A +V+EA AP+ +E E G VP E IESIR+ Sbjct: 20 KLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESIRK 79 Query: 399 NKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRH--ENVDIAVIREN 572 +V LKG L TPVG G S N+ LRK + YA++ P +PT + +D+ V+REN Sbjct: 80 TRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVVREN 139 Query: 573 TEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLAD 752 E Y+G+EH P V ++LK+++ SE+I ++AFE A RKKV K+NIMKLA+ Sbjct: 140 VEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKLAE 199 Query: 753 GLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAX 932 G + +VA +YP I+ IIVDN QLV +PEQF+V+VT N+ G+++S++ +G+ Sbjct: 200 GTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDLTSGLIG 259 Query: 933 XXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSF 1106 + A+FE G++ G + I NP A+ LS+ MMLR+L+ + Sbjct: 260 GLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVI------NPTAVLLSAVMMLRYLEEFAT 313 Query: 1107 ADRLESAVKGVIAEGKYRTRDLGG---TSTTQEVTDAVIAKLD*PP 1235 AD +E+A+ + EG+ T D+ G + T E T+A+I L P Sbjct: 314 ADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGKTP 359
>O29627:LEU3_ARCFU 3-isopropylmalate dehydrogenase - Archaeoglobus fulgidus| Length = 326 Score = 208 bits (530), Expect = 4e-53 Identities = 128/337 (37%), Positives = 190/337 (56%), Gaps = 7/337 (2%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM-----PSVPTEVIESIRRN 401 + + +IPGDGIG V A ++E + P + Y+ + ++P E +E+ R++ Sbjct: 2 KKIVVIPGDGIGKEVMEAAMLILEKLDLPFEYSYYDAGDEALEKYGKALPDETLEACRKS 61 Query: 402 KVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEG 581 L G G + + ++LR+EL +A++ + G+ + +DI V+RENTE Sbjct: 62 DAVLFGA----AGETAADVIVRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTEC 117 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 Y G E V E+++V+T+ SERIA+YAFE A RKKVTA+HKAN+MK GLF Sbjct: 118 LYMGFEFGF-GDVTEAIRVITREASERIARYAFELAKREGRKKVTALHKANVMKKTCGLF 176 Query: 762 LESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXX 941 + CREVA YP IQYN+ +D CM LV P +FDV+VT N++G++VS++AAG+ Sbjct: 177 RDVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFDVIVTTNMFGDIVSDLAAGLVGGLG 236 Query: 942 XXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADR 1115 + A+FE GA+ G + ANP A+ L++ MMLRH + A + Sbjct: 237 LAPSANVGERTAIFEPVHGAAFDIAG------KGIANPTAMILTACMMLRHFGYVEEAKK 290 Query: 1116 LESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 +E AV+ I EGK +T DLGG T E + V + LD Sbjct: 291 VEEAVEKTIKEGK-KTPDLGGNLKTMEFANEVASLLD 326
>P50455:LEU3_SULTO 3-isopropylmalate dehydrogenase - Sulfolobus tokodaii| Length = 337 Score = 192 bits (487), Expect = 4e-48 Identities = 126/347 (36%), Positives = 189/347 (54%), Gaps = 19/347 (5%) Frame = +3 Query: 240 TVTLIPGDGIGPLVTGAVRQVM----EAMHAPVCFETYEVHGDMP------SVPTEVIES 389 TV LI GDGIGP + ++++ E P+ + E GD ++P + ++ Sbjct: 4 TVALIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEVEA-GDRALARYGEALPKDSLKI 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRE 569 I + + LKG PVG + + ++LR+ D+YA++ ++PG+ T++ NVDI ++RE Sbjct: 63 IDKADIILKG----PVGESAADVVVKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVRE 118 Query: 570 NTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLA 749 NTE Y G EH V GV +K++T+F SERIAK +A L RKKVT VHKAN+M++ Sbjct: 119 NTEDLYKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFA-LRRRKKVTCVHKANVMRIT 177 Query: 750 DGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIA 929 DGLF E+CR V ++Y+E+ VD LV P+ FDV+VT N+YG+++S+ A+ IA Sbjct: 178 DGLFAEACRSVLK--GKVEYSEMYVDAAAANLVRNPQMFDVIVTENVYGDILSDEASQIA 235 Query: 930 XXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 A+FE GA+ G + NP A LS +MM + S Sbjct: 236 GSLGIAPSANIGDKKALFEPVHGAAFDIAG------KNIGNPTAFLLSVSMMYERMYELS 289 Query: 1104 FADR-------LESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 DR LE+A+ V E K T D+GG +TT ++ + + KL Sbjct: 290 NDDRYIKASRALENAIYLVYKERKALTPDVGGNATTDDLINEIYNKL 336
>Q1RJU4:ICD_RICBR Isocitrate dehydrogenase [NADP] - Rickettsia bellii (strain RML369-C)| Length = 483 Score = 191 bits (486), Expect = 5e-48 Identities = 119/326 (36%), Positives = 178/326 (54%), Gaps = 7/326 (2%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM------PSVPTEVIESIRRNK 404 +T+ GDGIGP + AV ++ A + ET EV + + + ESI R Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYVKHYSSGISEQSWESIERTG 66 Query: 405 VCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNL-PGLPTRHENVDIAVIRENTEG 581 V LK + TP GGG SLN+ +RK L L+A++ + P T H N+++ +IREN E Sbjct: 67 VILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFYPFTKTLHPNLNLTIIRENEED 126 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 Y+G+E+ + ES+K++++ E+I +YAFEYA NNRKKVT + K NIMK +DG+F Sbjct: 127 LYAGIEYRQTHNMYESVKLISRTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGIF 186 Query: 762 LESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXX 941 + E+A +YP I I+D +L KPE FDV+VT NLYG+++S+VAA I+ Sbjct: 187 HKVFNEIAKEYPQINNEHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVG 246 Query: 942 XXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRLE 1121 + +A+FE A + I Q ANP L ++ MML H+ A +E Sbjct: 247 LAGSANIGEHYAMFE----AVHGSAPDIAGQDIANPSGLLNAAIMMLVHIGQGDIATLIE 302 Query: 1122 SAVKGVIAEGKYRTRDLGGTSTTQEV 1199 +A K I +G + +T++V Sbjct: 303 NAWKKTIEDGMHTADIYNKDHSTKKV 328
>Q4UKR1:ICD_RICFE Isocitrate dehydrogenase [NADP] - Rickettsia felis (Rickettsia azadi)| Length = 483 Score = 190 bits (482), Expect = 2e-47 Identities = 117/312 (37%), Positives = 173/312 (55%), Gaps = 9/312 (2%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM------PSVPTEVIESIRRNK 404 +T+ GDGIGP + AV ++ A + ET EV + + E ESI+R Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTG 66 Query: 405 VCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNL-PGLPTRHENVDIAVIRENTEG 581 + LK + TP GGG SLN+ +RK L L+A++ + P T H ++++ +IREN E Sbjct: 67 IILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFHPFTMTLHPHLNLTIIRENEED 126 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 Y+G+E+ + ES+K+++ E+I +YAFEYA NNRKKVT + K NIMK +DG+F Sbjct: 127 LYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGVF 186 Query: 762 LESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXX 941 + E+A +YP I I+D +L KPE FDV+VT NLYG+++S+VAA I+ Sbjct: 187 HKIFNEIAKEYPQINNEHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVG 246 Query: 942 XXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADR 1115 Q +A+FE G++ G D ANP L ++ MML H+ A Sbjct: 247 LAGSANIGQHYAMFEAVHGSAPDIAGKD------IANPSGLLNAAIMMLVHIGQGDIASL 300 Query: 1116 LESAVKGVIAEG 1151 +E+A K I +G Sbjct: 301 IENAWKKTIEDG 312
>Q92IR7:IDH_RICCN Isocitrate dehydrogenase [NADP] - Rickettsia conorii| Length = 483 Score = 189 bits (479), Expect = 3e-47 Identities = 119/328 (36%), Positives = 179/328 (54%), Gaps = 9/328 (2%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM------PSVPTEVIESIRRNK 404 +T+ GDGIGP + AV ++ A + ET EV + + E ESI+R Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTG 66 Query: 405 VCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNL-PGLPTRHENVDIAVIRENTEG 581 + LK + TP GGG SLN+ +RK L L+A++ +L P T H N+++ +IREN E Sbjct: 67 IILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPAVSLHPFTRTLHPNLNLTIIRENEED 126 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 Y+G+E+ + ES+K+++ E+I +YAFEYA NNRKKV + K NIMK +DG+ Sbjct: 127 LYAGIEYRQTHNMYESMKLISHTGCEKIIRYAFEYAVKNNRKKVMCLSKDNIMKFSDGVL 186 Query: 762 LESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXX 941 + E+A +YP I I+D +L KPE FDV+VT NLYG+++S+VAA I+ Sbjct: 187 HKVFNEIAKEYPQINNAHYIIDIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVG 246 Query: 942 XXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADR 1115 Q +A+FE G++ G D ANP L ++ MML H+ A Sbjct: 247 LAGSANIGQHYAMFEAVHGSAPDIAGKD------IANPSGLLNAAIMMLVHIGQGDIATL 300 Query: 1116 LESAVKGVIAEGKYRTRDLGGTSTTQEV 1199 +E+A K I +G + S++++V Sbjct: 301 IENAWKKTIEDGVHTADIYNEQSSSKKV 328
>Q9ZDR0:IDH_RICPR Isocitrate dehydrogenase [NADP] - Rickettsia prowazekii| Length = 483 Score = 185 bits (470), Expect = 4e-46 Identities = 122/345 (35%), Positives = 180/345 (52%), Gaps = 13/345 (3%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM------PSVPTEVIESIRRNK 404 +T+ GDGIGP + AV ++ A + ET EV + + E + I+R Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARISLETIEVGEKLYKKHYTSGISEESWDVIQRTG 66 Query: 405 VCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNL-PGLPTRHENVDIAVIRENTEG 581 + LK + TP GG SLN+ +RK L L+A++ + P T H N+++ +IREN E Sbjct: 67 IILKAPITTPQSGGYKSLNVTIRKTLQLFANIRPVVSFYPFTRTLHPNLNLTIIRENEED 126 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 YSG+E+ + ES+K+++ ++I +YAFEYA NNRKKVT + K NIMK +DG+F Sbjct: 127 LYSGVEYRQTHNMYESMKLISHTGCKKIIRYAFEYAIKNNRKKVTCLTKDNIMKFSDGIF 186 Query: 762 LESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXX 941 E+A +YP I I+D +L KPE FD++VT NLYG+++S+VAA I+ Sbjct: 187 HRVFNEIAKEYPQINNEHYIIDIGTAKLATKPEIFDIIVTSNLYGDIISDVAAEISGSVG 246 Query: 942 XXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRL 1118 Q +A+FE SA ++ I ANP L ++ MML H+ A + Sbjct: 247 LAGSANIGQHYAMFEAVHGSAPDIAGKGI-----ANPSGLLNAAIMMLVHIGQGDIASLI 301 Query: 1119 ESAVKGVIAEGK-----YRTRDLGGTSTTQEVTDAVIAKLD*PPI 1238 E+A K I +G Y T+E VI +L PI Sbjct: 302 ENAWKKTIEDGVHTFDIYNEHSSSKKVCTKEFAVEVIKRLGQLPI 346
>Q68XA5:IDH_RICTY Isocitrate dehydrogenase [NADP] - Rickettsia typhi| Length = 483 Score = 185 bits (469), Expect = 5e-46 Identities = 120/340 (35%), Positives = 177/340 (52%), Gaps = 13/340 (3%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM------PSVPTEVIESIRRNK 404 +T+ GDGIGP + AV ++ A + ET EV + + E I+R Sbjct: 7 ITIAYGDGIGPEIMDAVLYILRQAEARISLETIEVGEKLYKKHYTSGISEESWNVIQRTG 66 Query: 405 VCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNL-PGLPTRHENVDIAVIRENTEG 581 + LK + TP GG SLN+ +RK L L+A++ + P T H N+++ +IREN E Sbjct: 67 IILKAPITTPQSGGYKSLNVTIRKTLQLFANIRPAVSFHPFTRTLHPNLNLTIIRENEED 126 Query: 582 EYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLF 761 YSG+E+ + ESLK+++ ++I +YAFEYA NNRKKVT + K NIMK +DG+F Sbjct: 127 LYSGIEYRQTHNMYESLKLISHTGCKKIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGIF 186 Query: 762 LESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXX 941 E+A +YP I I+D +L PE FD++VT NLYG+++S+VAA I+ Sbjct: 187 HRVFNEIAKEYPQIDNEHYIIDIGTAKLATTPEIFDIIVTSNLYGDIISDVAAEISGSVG 246 Query: 942 XXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRL 1118 Q +A+FE SA ++ I ANP L ++ MML H+ A + Sbjct: 247 LAGSANIGQHYAMFEAVHGSAPDIAGKGI-----ANPSGLLNAAIMMLVHIGQGDIASLI 301 Query: 1119 ESAVKGVIAEGK-----YRTRDLGGTSTTQEVTDAVIAKL 1223 E+A K I +G Y T+E + VI +L Sbjct: 302 ENAWKKTIEDGVHTFDIYSEHSSSKKVCTKEFAEEVIKRL 341
>O27441:LEU3_METTH 3-isopropylmalate dehydrogenase - Methanobacterium| thermoautotrophicum Length = 329 Score = 179 bits (454), Expect = 3e-44 Identities = 109/338 (32%), Positives = 183/338 (54%), Gaps = 10/338 (2%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM---------PSVPTEVIESIR 395 + +IPGDGIG V A ++ + + F +H D ++P E +E++ Sbjct: 6 IAVIPGDGIGVEVMEAALHILNTLDLDLEF----IHADAGDACLKRTGTALPEETLEAVG 61 Query: 396 RNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENT 575 + L G G + + ++LR+E DL+A+L +LPG+P + ++D ++RENT Sbjct: 62 EARATLFGA----AGESAADVIVRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENT 117 Query: 576 EGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADG 755 E Y G E G V +++T+ S RI+++AF+YA +KVTAVHKAN++K DG Sbjct: 118 EDLYVGDEEYTPEGAVAK-RIITRTASRRISQFAFQYAQKEGMQKVTAVHKANVLKKTDG 176 Query: 756 LFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXX 935 +F + +VA++YP ++ + VD M L+ +P++F +VT NL+G+++S+ AAG+ Sbjct: 177 IFRDEFYKVASEYPQMEATDYYVDATAMYLITQPQEFQTIVTTNLFGDILSDEAAGLIGG 236 Query: 936 XXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFAD 1112 + +A+FE SA + I ANP A+ L++ +ML+HL A Sbjct: 237 LGLAPSANIGEKNALFEPVHGSAPQIAGKNI-----ANPTAMILTTTLMLKHLNKKQEAQ 291 Query: 1113 RLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 ++E A++ +AEG T DLGG T E+ + L+ Sbjct: 292 KIEKALQKTLAEGLV-TPDLGGKLGTMEMAAEIARHLE 328
>Q58130:LEU3_METJA 3-isopropylmalate dehydrogenase - Methanococcus jannaschii| Length = 333 Score = 167 bits (424), Expect = 8e-41 Identities = 114/337 (33%), Positives = 176/337 (52%), Gaps = 10/337 (2%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM-----PSVPTEVIESIRRNKV 407 + +I GDGIG V A QV+EA P F E ++ ++P E IE+ Sbjct: 4 ICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAGDEVYKRTGKALPEETIETALDCDA 63 Query: 408 CLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENTEGEY 587 L G G + + ++LR LD YA++ G+ ++D ++RENTEG Y Sbjct: 64 VLFGA----AGETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYVIVRENTEGLY 119 Query: 588 SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAY----LNNRKKVTAVHKANIMKLADG 755 G+E E+ G+ + +V+T+ ERI ++AF A + KVT HKAN++KL DG Sbjct: 120 KGIEAEIDEGITIATRVITEKACERIFRFAFNLARERKKMGKEGKVTCAHKANVLKLTDG 179 Query: 756 LFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXX 935 LF + +VA +Y I+ + +D M ++ KP+ FDV+VT NL+G+++S+ AAG Sbjct: 180 LFKKIFYKVAEEYDDIKAEDYYIDAMNMYIITKPQVFDVVVTSNLFGDILSDGAAGTVGG 239 Query: 936 XXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFAD 1112 +H +FE SA ++ KI ANP A LS+ +MLR+L AD Sbjct: 240 LGLAPSANIGDEHGLFEPVHGSAPDIAGKKI-----ANPTATILSAVLMLRYLGEYEAAD 294 Query: 1113 RLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 ++E A++ V+A G T DLGG T E+ + V ++ Sbjct: 295 KVEKALEEVLALG-LTTPDLGGNLNTFEMAEEVAKRV 330
>Q9UXB2:LEU3_SULSO 3-isopropylmalate dehydrogenase - Sulfolobus solfataricus| Length = 336 Score = 163 bits (413), Expect = 2e-39 Identities = 113/341 (33%), Positives = 180/341 (52%), Gaps = 18/341 (5%) Frame = +3 Query: 243 VTLIPGDGIGP-LVTGAVRQVMEAMHA-PVCFETYEVH-GDMP------SVPTEVIESIR 395 V +IPGDGIGP L G+ R + + + + + EV GD+ ++P ++ I Sbjct: 5 VAVIPGDGIGPELYEGSKRIIAKLIEKYNLDIDLIEVEAGDVALNKYGEALPRHTLDVIE 64 Query: 396 RNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIAVIRENT 575 + + LKG PVG + ++LR+ D+YA++ +LP + +++ NVD+ ++RENT Sbjct: 65 KADMILKG----PVGETAMDVVVKLRQMYDMYANIRPAKSLPNVQSKYPNVDLVIVRENT 120 Query: 576 EGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADG 755 E Y G E GV ++KV T+F S+RI A YA L R+KVT VHKAN+M++ DG Sbjct: 121 EDLYKGFEFVTSTGVTIAIKVTTEFASKRIVNVALNYA-LMRRRKVTCVHKANVMRVTDG 179 Query: 756 LFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXX 935 LF CRE+ + + E+ VD LV P +FDV+VT N+YG+++S+ A+ IA Sbjct: 180 LFASVCREILK--GKVNFEEMYVDAAAANLVRDPTRFDVIVTSNVYGDILSDEASQIAGS 237 Query: 936 XXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHL------ 1091 ++FE GA+ G + ANP A LS +MML + Sbjct: 238 LGLAPSANIGDRKSMFEPVHGAAFDIAG------KGIANPTAFLLSVSMMLSRMYELSKE 291 Query: 1092 -QFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAV 1211 ++ + LE+A+ G T D+GG++ +++ D + Sbjct: 292 NKYILASKSLENAIIETYKSGNKLTEDVGGSAKLKDMVDEI 332
>Q58991:AKSF_METJA Threo-isocitrate dehydrogenase [NAD] - Methanococcus jannaschii| Length = 347 Score = 158 bits (400), Expect = 5e-38 Identities = 115/345 (33%), Positives = 182/345 (52%), Gaps = 21/345 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVM------EAMHAPVCFETYEVHGDMPSVPTEVIESIRRNK 404 V +I GDGIG V +++ E + E + +G+ ++P + IE + Sbjct: 4 VCVIEGDGIGKEVIPEAIKILNELGEFEIIKGEAGLECLKKYGN--ALPEDTIEKAKEAD 61 Query: 405 VCLKGGLATPVGGGVSSLN---LQLRKELDLYASL--VNCFNLPGLPTR--------HEN 545 + L G + +P G V + + LRK LYA++ +N F + L + +N Sbjct: 62 IILFGAITSPKPGEVQNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIADYEFLNAKN 121 Query: 546 VDIAVIRENTEGEYSGLEH-EVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 +DI +IRENTE Y G E E + E +V+T+ SERI ++AFEYA NNRKKV+ + Sbjct: 122 IDIVIIRENTEDLYVGRERLENDTAIAE--RVITRKGSERIIRFAFEYAIKNNRKKVSCI 179 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 HKAN++++ DGLFLE E+ Y I+ ++ +VD+ M L+ PE+FDV+VT N++G++ Sbjct: 180 HKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPEKFDVIVTTNMFGDI 238 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSAMM 1079 +S+ A+ + D A+FE SA ++ I ANP+A LS AM+ Sbjct: 239 LSDEASALIGGLGLAPSANIGDDKALFEPVHGSAPDIAGKGI-----ANPMASILSIAML 293 Query: 1080 LRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVI 1214 ++ D + AVK + K T DLGG T++V D ++ Sbjct: 294 FDYIGEKEKGDLIREAVKYCLINKKV-TPDLGGDLKTKDVGDEIL 337
>O29610:IDH_ARCFU Isocitrate dehydrogenase [NADP] - Archaeoglobus fulgidus| Length = 412 Score = 148 bits (374), Expect = 5e-35 Identities = 117/383 (30%), Positives = 183/383 (47%), Gaps = 61/383 (15%) Frame = +3 Query: 258 GDGIGPLVTGAVRQVMEAMHAPVCFET-----------YEVHGDMPSVPTEVIESIRRNK 404 GDGIG V A +V++A + E Y+++G+ +P + + +I+ + Sbjct: 35 GDGIGKDVVPAAIRVLDAAADKIGKEVVWFQVYAGEDAYKLYGNY--LPDDTLNAIKEFR 92 Query: 405 VCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPT--RH-ENVDIAVIRENT 575 V LKG L TPVGGG SLN+ +R+ LDLYA++ + L G+P+ +H E V+ + RENT Sbjct: 93 VALKGPLTTPVGGGYRSLNVTIRQVLDLYANVRPVYYLKGVPSPIKHPEKVNFVIFRENT 152 Query: 576 EGEYSGLEHEVVPGVVESLKV----------------------MTKFCSERIAKYAFEYA 689 E Y+G+E G E+LK+ +++F ++R+ + A YA Sbjct: 153 EDVYAGIEWP--RGSEEALKLIRFLKNEFGVTIREDSGIGIKPISEFATKRLVRMAIRYA 210 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVA---------------TKYPG------IQ 806 NNRK VT VHK NIMK +G F + EVA KY G I Sbjct: 211 IENNRKSVTLVHKGNIMKYTEGAFRDWGYEVAKQEFGEYCITEDELWDKYGGKQPEGKIV 270 Query: 807 YNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFE 986 + I DN Q++ + +++DV+ PNL G+ +S+ AA + VFE Sbjct: 271 VKDRIADNMFQQILTRTDEYDVIALPNLNGDYLSDAAAALIGGLGIAPGSNIGDGIGVFE 330 Query: 987 QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRLESAVKGVIAEGKYR-- 1160 + K Q K NP A L+ A+M ++ + ++ ++ AV+ I+ G Sbjct: 331 PVHGSA----PKYAGQNKVNPTAEILTGALMFEYIGWKDASEMIKKAVEMTISSGIVTYD 386 Query: 1161 -TRDLGGTST-TQEVTDAVIAKL 1223 R +GGT T+E +AV+ L Sbjct: 387 IHRHMGGTKVGTREFAEAVVENL 409
>P40495:LYS12_YEAST Homoisocitrate dehydrogenase, mitochondrial precursor - Saccharomyces| cerevisiae (Baker's yeast) Length = 371 Score = 147 bits (372), Expect = 9e-35 Identities = 110/356 (30%), Positives = 185/356 (51%), Gaps = 28/356 (7%) Frame = +3 Query: 240 TVTLIPGDGIGPLVTGAVRQVMEAMHAP-----------VCFETYEVHGDMPSVPTEVIE 386 T+ LIPGDGIG V A +QV+E +++ F+T++ G ++P E ++ Sbjct: 25 TIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGK--ALPDETVK 82 Query: 387 SIRRN-KVCLKGGLATPVGG--GVSSLNLQLRKELDLYASLVNCFNLPGLPTRHENVDIA 557 ++ + L G + +P G SS + LR+E+ L+A++ ++ G + + +D+ Sbjct: 83 VLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEG--EKGKPIDMV 140 Query: 558 VIRENTEGEYSGLEHEVVPG-----VVESLKVMTKFCSERIAKYAFEYAY----LNNRKK 710 ++RENTE Y +E + V ++ K +++ + RIA A + A + Sbjct: 141 IVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALKRLQTRGQAT 200 Query: 711 VTAVHKANIMKLADGLFLESCREV----ATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 +T HK+N++ +DGLF E C+EV KY I+YNE IVD+ +L +P+ FDV+V Sbjct: 201 LTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMVYRLFREPQCFDVIV 260 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVA 1055 PNLYG+++S+ AA + + + E SA ++ I ANP+A Sbjct: 261 APNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGI-----ANPIA 315 Query: 1056 LFLSSAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 S+A+ML L A + AV + EG +T DLGG ++TQ+V D V+++L Sbjct: 316 TIRSTALMLEFLGHNEAAQDIYKAVDANLREGSIKTPDLGGKASTQQVVDDVLSRL 371
>Q59985:IDH_STRSL Isocitrate dehydrogenase [NADP] - Streptococcus salivarius| Length = 391 Score = 139 bits (350), Expect = 3e-32 Identities = 103/291 (35%), Positives = 152/291 (52%), Gaps = 35/291 (12%) Frame = +3 Query: 366 VPTEVIESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASL--VNCFNLPGLPTRH 539 +P E +E+IR + V +KG L TPVGGG+ SLN+ LR+ELDLYA + V F+ P + Sbjct: 73 LPKETLEAIRESLVAIKGPLETPVGGGIRSLNVALRQELDLYACVRPVRYFDGVASPLKE 132 Query: 540 -ENVDIAVIRENTEGEYSGLEHEV----VPGVVE-------------------SLKVMTK 647 E +I + RENTE Y+G+E E V V+E +K ++ Sbjct: 133 PEKTNITIFRENTEDIYAGIEWEAGTADVKRVIEFLQTEMNVNKIRFPESSSIGIKPISI 192 Query: 648 FCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATK-------YPGIQ 806 S+R+ + A +YA NN KKVT VHK NI K +G F + EVA + ++ Sbjct: 193 EGSKRLIRSAIDYALKNNLKKVTLVHKGNIQKFTEGGFRKWGYEVAQEDYKEELLAGRLE 252 Query: 807 YNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSN-VAAGIAXXXXXXXXXXXXQ-DHAV 980 N+II DN Q++ PE+FDV+ NL G+ S+ +AA + Q HA+ Sbjct: 253 INDIIADNFLQQILLNPEKFDVVALTNLNGDYASDALAAQVGGIGISPGANINYQTGHAI 312 Query: 981 FEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRLESAVK 1133 FE A+ G + I Q KANP ++ LS M+L ++ + A + SA++ Sbjct: 313 FE--ATHGTAPD--IADQDKANPCSVLLSGCMLLDYIGWTEAAQLITSAIE 359
>P08200:IDH_ECOLI Isocitrate dehydrogenase [NADP] - Escherichia coli| Length = 416 Score = 139 bits (350), Expect = 3e-32 Identities = 111/360 (30%), Positives = 169/360 (46%), Gaps = 60/360 (16%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEA--------------MHAPVCFETYEVHGDMPSVPTEV 380 + I GDGIG VT A+ +V++A M ++ +V+G +P E Sbjct: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 Query: 381 IESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASL--VNCFNLPGLPTRH-ENVD 551 ++ IR +V +KG L TPVGGG+ SLN+ LR+ELDLY L V + P +H E D Sbjct: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 Query: 552 IAVIRENTEGEYSGLE--------HEVVPGVVESLKVM-----------TKFCSE----R 662 + + REN+E Y+G+E +V+ + E + V K CSE R Sbjct: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 Query: 663 IAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPG-------------- 800 + + A EYA N+R VT VHK NIMK +G F + ++A + G Sbjct: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKN 268 Query: 801 ------IQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXX 962 I ++I D Q++ +P ++DV+ NL G+ +S+ A Sbjct: 269 PNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANI 328 Query: 963 XQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRLESAVKGVI 1142 + A+FE A+ G K Q K NP ++ LS+ MMLRH+ + AD + ++G I Sbjct: 329 GDECALFE--ATHGTA--PKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384
>Q02143:LEU3_LACLA 3-isopropylmalate dehydrogenase - Lactococcus lactis subsp. lactis| (Streptococcus lactis) Length = 345 Score = 136 bits (342), Expect = 3e-31 Identities = 112/350 (32%), Positives = 175/350 (50%), Gaps = 24/350 (6%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV------------HGDMPSVPTEV 380 + + + GDGIGP + A V++A+ + FE YE+ HG +P E Sbjct: 3 KKIVTLAGDGIGPEIMSAGLSVLKAVSKKIDFE-YELEAKDFGGIAIDKHGH--PLPEET 59 Query: 381 IESIRRNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGL----PTR 536 +++++ L + P L LRKEL LYA++ P L P R Sbjct: 60 LQAVKNADAILLAAIGHPKYNNAKVRPEQGLLALRKELGLYANVRPLKIYPALKKLSPIR 119 Query: 537 H-ENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKV 713 + ENVD VIRE T G Y G +HE+ + + RI +AF+ A RK + Sbjct: 120 NVENVDFLVIRELTGGIYFG-QHELADDKARDVNDYSADEIRRILHFAFKSAQSRPRKLL 178 Query: 714 TAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 893 T+V K N++ + L+ + E+A +YP ++ +VD+C M L+ P+QFDV+VT NL+ Sbjct: 179 TSVDKQNVLATSK-LWRKMADEIADEYPDVRLEHQLVDSCAMLLITNPQQFDVIVTENLF 237 Query: 894 GNLVSNVAAGIA-XXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLS 1067 G+++S+ A+ +A A++E SA ++ I ANPV++ LS Sbjct: 238 GDILSDEASSLAGSLGVMPSSSHGFNGLALYEPIHGSAPDIAGKGI-----ANPVSMILS 292 Query: 1068 SAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVI 1214 AMMLR A +E AV +G T+DLGGT+TT+E+T+A++ Sbjct: 293 IAMMLRESFGQEDGAAMIEKAVTQTFTDG-ILTKDLGGTATTKEMTEAIL 341
>Q48806:DLPA_LEGPH Protein dlpA - Legionella pneumophila subsp. pneumophila (strain| Philadelphia 1 / ATCC 33152 / DSM 7513) Length = 615 Score = 135 bits (341), Expect = 3e-31 Identities = 96/366 (26%), Positives = 174/366 (47%), Gaps = 39/366 (10%) Frame = +3 Query: 234 PRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM-----PSVPTEVIESIRR 398 P + ++PGDGIG VT A V E + PV ++ + ++P+ + I Sbjct: 6 PIKIAVLPGDGIGIEVTEATLPVFEVLDVPVILNYGDIGWEFWKKEGAAIPSRTWQLIAS 65 Query: 399 NKVCLKGGLATP--------VGGGVSSLN-------LQLRKELDLYASLVNCFNLPGLPT 533 + L G + + + + N +QLR+ LDL+A++ CF++ Sbjct: 66 SDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSIDD--- 122 Query: 534 RHENVDIAVIRENTEGEYSGLEHEVVPGVVESL-------------------KVMTKFCS 656 + + + +IREN+EG Y G ++ +P + SL ++ +K Sbjct: 123 QSKPFNFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEASCALRLQSKSGL 182 Query: 657 ERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCC 836 R+ +AF++A +VT K N+++ + + A +YP IQ + + VD Sbjct: 183 TRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPKIQADILNVDAVA 242 Query: 837 MQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGN 1016 + L+ PE+F V+V N++G+++S+V AG+ + FE +G Sbjct: 243 LWLIKSPEKFGVIVAENMFGDILSDVGAGVMGGLGLAPSANIGDKGSYFEPVHGSG---- 298 Query: 1017 DKILQQKKANPVALFLSSAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQE 1196 +++ ANP A+FL+ +M+L H +P A ++ +AV VI E ++ T DLGG +TT + Sbjct: 299 -PRIRKNCANPSAMFLTISMLLNHFGYPDRAKKIVNAVMQVIKEKRFITYDLGGHATTTD 357 Query: 1197 VTDAVI 1214 + +AVI Sbjct: 358 MANAVI 363
>P59028:LEU3_CHLTE 3-isopropylmalate dehydrogenase - Chlorobium tepidum| Length = 352 Score = 134 bits (336), Expect = 1e-30 Identities = 107/358 (29%), Positives = 170/358 (47%), Gaps = 31/358 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE-----------TYEVHGDMPSVPTEVIES 389 + IPGDGIGP V V+ A+ FE +Y+VHG M + E +E+ Sbjct: 5 IVSIPGDGIGPEVVAGALDVLNAVAKKHGFEVSVEEHLFGGASYDVHGSM--LTDETLEA 62 Query: 390 IRRNKVCLKGGLA------TPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRH---- 539 + L G + P + L++RKEL L+A+L L Sbjct: 63 CKNCDAVLLGAVGGYKWENLPHDKKPEAALLKIRKELGLFANLRPARVYDALVASSTLKT 122 Query: 540 ---ENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKK 710 + D V RE T G Y G + V ++ ERIA+ AFEYA K Sbjct: 123 EVVQGTDFMVFRELTGGIYFGQPRGYDETRGWNTMVYERYEVERIARLAFEYAQKRGNAK 182 Query: 711 VTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNL 890 VT++ KAN+++++ + EV +P I+ ++ VDN MQ+V P+QF+V+VT NL Sbjct: 183 VTSIDKANVLEVSQ-FWRNIVHEVHQDFPEIELVDMYVDNAAMQVVRNPKQFEVIVTSNL 241 Query: 891 YGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFL 1064 +G+++S+++ I +HA++E G++ G Q KANP+A Sbjct: 242 FGDILSDISGMITGSLGMLPSASIGSEHALYEPIHGSAPDIAG------QNKANPIATIA 295 Query: 1065 SSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGT----STTQEVTDAVIAKL 1223 S AMM + P A + +A++G +A G +RT D+ S+T E+T A++A++ Sbjct: 296 SVAMMFENSFNRPEVAADIYAAIEGALAAG-FRTGDIAAAGEAISSTTEMTAAIVARI 352
>Q8CNX4:IDH_STAES Isocitrate dehydrogenase [NADP] - Staphylococcus epidermidis (strain| ATCC 12228) Length = 422 Score = 133 bits (335), Expect = 2e-30 Identities = 110/374 (29%), Positives = 169/374 (45%), Gaps = 73/374 (19%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----HAPVCFETYEVHGDMPS-------VPTEVIE 386 + I GDGIGP + A +V++A + E EV + +P E +E Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAYDETGEWLPQETLE 80 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPT---RHENVDIA 557 +I+ + +KG L TP+GGG+ SLN+ LR+ELDL+ L G+P+ R E+VD+ Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPEDVDMV 140 Query: 558 VIRENTEGEYSGLEHEVVPGVVE-----------------------SLKVMTKFCSERIA 668 + RENTE Y+G+E + V+ +K ++K +ER+ Sbjct: 141 IFRENTEDIYAGIEFKQGTSEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 669 KYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATK------YPGIQYNEI---- 818 + A +YA NNRK VT VHK NIMK +G F + ++A + QY+EI Sbjct: 201 RAAIQYALDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAHNEFGDKVFTWQQYDEIVEQK 260 Query: 819 -----------------------IVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIA 929 I D Q++ +P + DV+ T NL G+ +S+ A Sbjct: 261 GKDAANEAQSKAEQEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV 320 Query: 930 XXXXXXXXXXXXQD--HAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 + HA+FE A+ G K K NP + LSS +ML HL + Sbjct: 321 GGIGIAPGANINYETGHAIFE--ATHGTA--PKYAGLNKVNPSSEILSSVLMLEHLGWQE 376 Query: 1104 FADRLESAVKGVIA 1145 AD++ +++ IA Sbjct: 377 AADKITDSIEATIA 390
>Q5HNL1:IDH_STAEQ Isocitrate dehydrogenase [NADP] - Staphylococcus epidermidis (strain| ATCC 35984 / RP62A) Length = 422 Score = 133 bits (335), Expect = 2e-30 Identities = 110/374 (29%), Positives = 169/374 (45%), Gaps = 73/374 (19%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----HAPVCFETYEVHGDMPS-------VPTEVIE 386 + I GDGIGP + A +V++A + E EV + +P E +E Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAYDETGEWLPQETLE 80 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPT---RHENVDIA 557 +I+ + +KG L TP+GGG+ SLN+ LR+ELDL+ L G+P+ R E+VD+ Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPEDVDMV 140 Query: 558 VIRENTEGEYSGLEHEVVPGVVE-----------------------SLKVMTKFCSERIA 668 + RENTE Y+G+E + V+ +K ++K +ER+ Sbjct: 141 IFRENTEDIYAGIEFKQGTSEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 669 KYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATK------YPGIQYNEI---- 818 + A +YA NNRK VT VHK NIMK +G F + ++A + QY+EI Sbjct: 201 RAAIQYALDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAHNEFGDKVFTWQQYDEIVEQK 260 Query: 819 -----------------------IVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIA 929 I D Q++ +P + DV+ T NL G+ +S+ A Sbjct: 261 GKDAANEAQSKAEQEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV 320 Query: 930 XXXXXXXXXXXXQD--HAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 + HA+FE A+ G K K NP + LSS +ML HL + Sbjct: 321 GGIGIAPGANINYETGHAIFE--ATHGTA--PKYAGLNKVNPSSEILSSVLMLEHLGWQE 376 Query: 1104 FADRLESAVKGVIA 1145 AD++ +++ IA Sbjct: 377 AADKITDSIEATIA 390
>Q8NW61:IDH_STAAW Isocitrate dehydrogenase [NADP] - Staphylococcus aureus (strain MW2)| Length = 422 Score = 133 bits (334), Expect = 2e-30 Identities = 108/374 (28%), Positives = 170/374 (45%), Gaps = 73/374 (19%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----HAPVCFETYEVHGDMPS-------VPTEVIE 386 + I GDGIGP + A +V++A + E EV + +P E ++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPT---RHENVDIA 557 +I+ + +KG L TP+GGG+ SLN+ LR+ELDL+ L G+P+ R ++VD+ Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMV 140 Query: 558 VIRENTEGEYSGLEHE----VVPGVVE-------------------SLKVMTKFCSERIA 668 + RENTE Y+G+E + V V++ +K ++K +ER+ Sbjct: 141 IFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 669 KYAFEYAYLNNRKKVTAVHKANIMKLADGLFLE--------------------------- 767 + A +YA NNRK VT VHK NIMK +G F + Sbjct: 201 RAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALSEFGDQVFTWQQYDEIVEKE 260 Query: 768 ------SCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIA 929 + +E A K I + I D Q++ +P + DV+ T NL G+ +S+ A Sbjct: 261 GRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV 320 Query: 930 XXXXXXXXXXXXQD--HAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 + HA+FE A+ G K K NP ++ LSS +ML HL + Sbjct: 321 GGIGIAPGANINYETGHAIFE--ATHGTA--PKYAGLNKVNPSSVILSSVLMLEHLGWQE 376 Query: 1104 FADRLESAVKGVIA 1145 AD++ +++ IA Sbjct: 377 AADKITDSIEDTIA 390
>Q6G8N2:IDH_STAAS Isocitrate dehydrogenase [NADP] - Staphylococcus aureus (strain| MSSA476) Length = 422 Score = 133 bits (334), Expect = 2e-30 Identities = 108/374 (28%), Positives = 170/374 (45%), Gaps = 73/374 (19%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----HAPVCFETYEVHGDMPS-------VPTEVIE 386 + I GDGIGP + A +V++A + E EV + +P E ++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPT---RHENVDIA 557 +I+ + +KG L TP+GGG+ SLN+ LR+ELDL+ L G+P+ R ++VD+ Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMV 140 Query: 558 VIRENTEGEYSGLEHE----VVPGVVE-------------------SLKVMTKFCSERIA 668 + RENTE Y+G+E + V V++ +K ++K +ER+ Sbjct: 141 IFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 669 KYAFEYAYLNNRKKVTAVHKANIMKLADGLFLE--------------------------- 767 + A +YA NNRK VT VHK NIMK +G F + Sbjct: 201 RAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALSEFGDQVFTWQQYDEIVEKE 260 Query: 768 ------SCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIA 929 + +E A K I + I D Q++ +P + DV+ T NL G+ +S+ A Sbjct: 261 GRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV 320 Query: 930 XXXXXXXXXXXXQD--HAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 + HA+FE A+ G K K NP ++ LSS +ML HL + Sbjct: 321 GGIGIAPGANINYETGHAIFE--ATHGTA--PKYAGLNKVNPSSVILSSVLMLEHLGWQE 376 Query: 1104 FADRLESAVKGVIA 1145 AD++ +++ IA Sbjct: 377 AADKITDSIEDTIA 390
>P99167:IDH_STAAN Isocitrate dehydrogenase [NADP] - Staphylococcus aureus (strain N315)| Length = 422 Score = 133 bits (334), Expect = 2e-30 Identities = 108/374 (28%), Positives = 170/374 (45%), Gaps = 73/374 (19%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----HAPVCFETYEVHGDMPS-------VPTEVIE 386 + I GDGIGP + A +V++A + E EV + +P E ++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPT---RHENVDIA 557 +I+ + +KG L TP+GGG+ SLN+ LR+ELDL+ L G+P+ R ++VD+ Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMV 140 Query: 558 VIRENTEGEYSGLEHE----VVPGVVE-------------------SLKVMTKFCSERIA 668 + RENTE Y+G+E + V V++ +K ++K +ER+ Sbjct: 141 IFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 669 KYAFEYAYLNNRKKVTAVHKANIMKLADGLFLE--------------------------- 767 + A +YA NNRK VT VHK NIMK +G F + Sbjct: 201 RAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALSEFGDQVFTWQQYDEIVENE 260 Query: 768 ------SCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIA 929 + +E A K I + I D Q++ +P + DV+ T NL G+ +S+ A Sbjct: 261 GRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV 320 Query: 930 XXXXXXXXXXXXQD--HAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 + HA+FE A+ G K K NP ++ LSS +ML HL + Sbjct: 321 GGIGIAPGANINYETGHAIFE--ATHGTA--PKYAGLNKVNPSSVILSSVLMLEHLGWQE 376 Query: 1104 FADRLESAVKGVIA 1145 AD++ +++ IA Sbjct: 377 AADKITDSIEDTIA 390
>P65099:IDH_STAAM Isocitrate dehydrogenase [NADP] - Staphylococcus aureus (strain Mu50| / ATCC 700699) Length = 422 Score = 133 bits (334), Expect = 2e-30 Identities = 108/374 (28%), Positives = 170/374 (45%), Gaps = 73/374 (19%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----HAPVCFETYEVHGDMPS-------VPTEVIE 386 + I GDGIGP + A +V++A + E EV + +P E ++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPT---RHENVDIA 557 +I+ + +KG L TP+GGG+ SLN+ LR+ELDL+ L G+P+ R ++VD+ Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMV 140 Query: 558 VIRENTEGEYSGLEHE----VVPGVVE-------------------SLKVMTKFCSERIA 668 + RENTE Y+G+E + V V++ +K ++K +ER+ Sbjct: 141 IFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 669 KYAFEYAYLNNRKKVTAVHKANIMKLADGLFLE--------------------------- 767 + A +YA NNRK VT VHK NIMK +G F + Sbjct: 201 RAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALSEFGDQVFTWQQYDEIVENE 260 Query: 768 ------SCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIA 929 + +E A K I + I D Q++ +P + DV+ T NL G+ +S+ A Sbjct: 261 GRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV 320 Query: 930 XXXXXXXXXXXXQD--HAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 + HA+FE A+ G K K NP ++ LSS +ML HL + Sbjct: 321 GGIGIAPGANINYETGHAIFE--ATHGTA--PKYAGLNKVNPSSVILSSVLMLEHLGWQE 376 Query: 1104 FADRLESAVKGVIA 1145 AD++ +++ IA Sbjct: 377 AADKITDSIEDTIA 390
>Q5HF79:IDH_STAAC Isocitrate dehydrogenase [NADP] - Staphylococcus aureus (strain COL)| Length = 422 Score = 133 bits (334), Expect = 2e-30 Identities = 108/374 (28%), Positives = 170/374 (45%), Gaps = 73/374 (19%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----HAPVCFETYEVHGDMPS-------VPTEVIE 386 + I GDGIGP + A +V++A + E EV + +P E ++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPT---RHENVDIA 557 +I+ + +KG L TP+GGG+ SLN+ LR+ELDL+ L G+P+ R ++VD+ Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMV 140 Query: 558 VIRENTEGEYSGLEHE----VVPGVVE-------------------SLKVMTKFCSERIA 668 + RENTE Y+G+E + V V++ +K ++K +ER+ Sbjct: 141 IFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 669 KYAFEYAYLNNRKKVTAVHKANIMKLADGLFLE--------------------------- 767 + A +YA NNRK VT VHK NIMK +G F + Sbjct: 201 RAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALSEFGDQVFTWQQYDEIVENE 260 Query: 768 ------SCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIA 929 + +E A K I + I D Q++ +P + DV+ T NL G+ +S+ A Sbjct: 261 GRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV 320 Query: 930 XXXXXXXXXXXXQD--HAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 + HA+FE A+ G K K NP ++ LSS +ML HL + Sbjct: 321 GGIGIAPGANINYETGHAIFE--ATHGTA--PKYAGLNKVNPSSVILSSVLMLEHLGWQE 376 Query: 1104 FADRLESAVKGVIA 1145 AD++ +++ IA Sbjct: 377 AADKITDSIEDTIA 390
>Q44471:TTUC1_AGRVI Probable tartrate dehydrogenase/decarboxylase ttuC - Agrobacterium| vitis (Rhizobium vitis) Length = 364 Score = 132 bits (333), Expect = 3e-30 Identities = 109/351 (31%), Positives = 179/351 (50%), Gaps = 28/351 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHA-----PVCFET-------YEVHGDMPSVPTEVIE 386 + IP DGIGP V A QV+EA+ + ET Y+ HG M +P + ++ Sbjct: 6 IAAIPADGIGPEVIAAGLQVLEALEQRSGDFKIHTETFDWGSDYYKKHGVM--MPADGLD 63 Query: 387 SIRRNKVCLKGGLATP-VGGGVS--SLNLQLRKELDLYASLVNCFNLPGL--PTRH---E 542 +++ G + P V ++ L L + + D YA++ LPG+ P R+ Sbjct: 64 KLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGITPPLRNCGPG 123 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESL----KVMTKFCSERIAKYAFEYAYLNNRKK 710 ++D ++REN+EGEYSG G+ E + + T+ RI +YAF+ A RK Sbjct: 124 DLDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRKL 183 Query: 711 VTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNL 890 +T V K+N + ++ E EVAT++P + +++++VD +++ KPE D +V NL Sbjct: 184 LTVVTKSNAQRHGMVMWDEIAAEVATEFPDVTWDKMLVDAMTVRMTLKPETLDTIVATNL 243 Query: 891 YGNLVSNVAAGIAXXXXXXXXXXXXQDH---AVFEQ-GASAGNVGNDKILQQKKANPVAL 1058 + +++S++A +A + ++FE SA ++ I ANP+A Sbjct: 244 HADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGI-----ANPIAT 298 Query: 1059 FLSSAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAV 1211 F ++A ML HL A RL SAV+ V E T D+GGT+ T++VT+AV Sbjct: 299 FWTAAQMLEHLGERDAAARLMSAVERV-TEAGILTPDVGGTANTRQVTEAV 348
>P70792:TTUC4_AGRVI Probable tartrate dehydrogenase/decarboxylase ttuC' - Agrobacterium| vitis (Rhizobium vitis) Length = 358 Score = 132 bits (332), Expect = 4e-30 Identities = 107/349 (30%), Positives = 176/349 (50%), Gaps = 26/349 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHA-----PVCFETYEVHGDMPS-----VPTEVIESI 392 + IP DGIGP V A QV+EA+ + ET++ D +P + +E + Sbjct: 6 IAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDWGSDYYKKNGVMMPADGLEQL 65 Query: 393 RRNKVCLKGGLATP-VGGGVS--SLNLQLRKELDLYASLVNCFNLPGL--PTRH---ENV 548 ++ G + P V ++ L L + + D YA++ LPG+ P R+ ++ Sbjct: 66 KKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLRNCGPGDL 125 Query: 549 DIAVIRENTEGEYSGLEHEVVPGVVESL----KVMTKFCSERIAKYAFEYAYLNNRKKVT 716 D ++REN+EGEYSG G+ E + + T+ RI +YAF+ A RK +T Sbjct: 126 DWVIVRENSEGEYSGHGGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRKLLT 185 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 V K+N + ++ E EV+ ++P + +++++VD +++ KP+ D +V NL+ Sbjct: 186 VVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQSLDTIVATNLHA 245 Query: 897 NLVSNVAAGIAXXXXXXXXXXXXQDH---AVFEQ-GASAGNVGNDKILQQKKANPVALFL 1064 +++S++A +A + ++FE SA ++ I ANPVA F Sbjct: 246 DILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGI-----ANPVATFW 300 Query: 1065 SSAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAV 1211 ++A ML HL A RL SAV+ V E T D+GGT+ TQ+VTDAV Sbjct: 301 TAAQMLEHLGEKDAATRLMSAVERV-TEAGILTPDVGGTANTQQVTDAV 348
>O34296:TTUC3_AGRVI Probable tartrate dehydrogenase/decarboxylase ttuC' - Agrobacterium| vitis (Rhizobium vitis) Length = 358 Score = 132 bits (332), Expect = 4e-30 Identities = 109/351 (31%), Positives = 178/351 (50%), Gaps = 28/351 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHA-----PVCFET-------YEVHGDMPSVPTEVIE 386 + IP DGIGP V A QV+EA+ + ET Y+ HG M +P + ++ Sbjct: 6 IAAIPADGIGPEVIAAGLQVLEALEQRSGDFKIHTETFDWGSDYYKKHGVM--MPADGLD 63 Query: 387 SIRRNKVCLKGGLATP-VGGGVS--SLNLQLRKELDLYASLVNCFNLPGL--PTRH---E 542 +++ G + P V ++ L L + + D YA++ LPG+ P R+ Sbjct: 64 KLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGITPPLRNCGPG 123 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESL----KVMTKFCSERIAKYAFEYAYLNNRKK 710 ++D ++REN+EGEYSG G+ E + + T+ RI +YAF+ A RK Sbjct: 124 DLDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRKL 183 Query: 711 VTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNL 890 +T V K+N + ++ E EVAT++P + +++++VD +++ KPE D +V NL Sbjct: 184 LTVVTKSNAQRHGMVMWDEIAAEVATEFPDVTWDKMLVDAMTVRMTLKPETLDTIVATNL 243 Query: 891 YGNLVSNVAAGIAXXXXXXXXXXXXQDH---AVFEQ-GASAGNVGNDKILQQKKANPVAL 1058 + +++S++A +A + ++FE SA ++ I ANP+A Sbjct: 244 HADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGI-----ANPIAT 298 Query: 1059 FLSSAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAV 1211 F ++A ML HL A RL SAV+ V E T D+GGT+ T +VT+AV Sbjct: 299 FWTAAQMLEHLGERDAAARLMSAVERV-TEAGILTPDVGGTANTSQVTEAV 348
>Q6GG12:IDH_STAAR Isocitrate dehydrogenase [NADP] - Staphylococcus aureus (strain| MRSA252) Length = 422 Score = 132 bits (332), Expect = 4e-30 Identities = 109/374 (29%), Positives = 172/374 (45%), Gaps = 73/374 (19%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----HAPVCFETYEVHGDMPS-------VPTEVIE 386 + I GDGIGP + A +V++A + E EV + +P E ++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPT---RHENVDIA 557 +I+ + +KG L TP+GGG+ SLN+ LR+ELDL+ L G+P+ R ++VD+ Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMV 140 Query: 558 VIRENTEGEYSGLEHE----VVPGVVE-------------------SLKVMTKFCSERIA 668 + RENTE Y+G+E + V V++ +K ++K +ER+ Sbjct: 141 IFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 669 KYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATK------YPGIQYNEI---- 818 + A +YA NNRK VT VHK NIMK +G F + ++A + QY+EI Sbjct: 201 RAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFTWQQYDEIVEKE 260 Query: 819 -----------------------IVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIA 929 I D Q++ +P + DV+ T NL G+ +S+ A Sbjct: 261 GRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV 320 Query: 930 XXXXXXXXXXXXQD--HAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPS 1103 + HA+FE A+ G K K NP ++ LSS +ML HL + Sbjct: 321 GGIGIAPGANINYETGHAIFE--ATHGTA--PKYAGLNKVNPSSVILSSVLMLEHLGWQE 376 Query: 1104 FADRLESAVKGVIA 1145 AD++ +++ IA Sbjct: 377 AADKITDSIEDTIA 390
>P70787:TTUC2_AGRVI Probable tartrate dehydrogenase/decarboxylase ttuC - Agrobacterium| vitis (Rhizobium vitis) Length = 364 Score = 132 bits (331), Expect = 5e-30 Identities = 107/349 (30%), Positives = 176/349 (50%), Gaps = 26/349 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHA-----PVCFETYEVHGDMPS-----VPTEVIESI 392 + IP DGIGP V A QV+EA+ + ET++ D +P + +E + Sbjct: 6 IAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDWGSDYYKKNGVMMPADGLEQL 65 Query: 393 RRNKVCLKGGLATP-VGGGVS--SLNLQLRKELDLYASLVNCFNLPGL--PTRH---ENV 548 ++ G + P V ++ L L + + D YA++ LPG+ P R+ ++ Sbjct: 66 KKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLRNCGPGDL 125 Query: 549 DIAVIRENTEGEYSGLEHEVVPGVVESL----KVMTKFCSERIAKYAFEYAYLNNRKKVT 716 D ++REN+EGEYSG G+ E + + T+ RI +YAF+ A RK +T Sbjct: 126 DWVIVRENSEGEYSGHGGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRKLLT 185 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 V K+N + ++ E EV+ ++P + +++++VD +++ KP+ D +V NL+ Sbjct: 186 VVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQSLDTIVATNLHA 245 Query: 897 NLVSNVAAGIAXXXXXXXXXXXXQDH---AVFEQ-GASAGNVGNDKILQQKKANPVALFL 1064 +++S++A +A + ++FE SA ++ I ANPVA F Sbjct: 246 DILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGI-----ANPVATFW 300 Query: 1065 SSAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAV 1211 ++A ML HL A RL SAV+ V E T D+GGT+ TQ+VTDAV Sbjct: 301 TAAQMLEHLGEKDAATRLMSAVERV-TEAGILTPDVGGTADTQQVTDAV 348
>Q59940:IDH_STRMU Isocitrate dehydrogenase [NADP] - Streptococcus mutans| Length = 393 Score = 131 bits (330), Expect = 6e-30 Identities = 105/325 (32%), Positives = 163/325 (50%), Gaps = 39/325 (12%) Frame = +3 Query: 366 VPTEVIESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASL--VNCFNLPGLPTRH 539 +P E +E I+ + + +KG L TPVGGG+ SLN+ LR+ELDL+A + V F P +H Sbjct: 73 LPNETLEIIKTHLLAIKGPLETPVGGGIRSLNVALRQELDLFACVRPVRYFKGVPSPLKH 132 Query: 540 -ENVDIAVIRENTEGEYSGLEHEVVPGVVES-----------------------LKVMTK 647 E I + RENTE Y+G+E V+ +K ++ Sbjct: 133 PEKTAITIFRENTEDIYAGIEWNAGTAEVQKVINFLQDDMQVKKIRFPKSSSIGIKPISI 192 Query: 648 FCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLE-----SCREVATKYPGIQ-- 806 S+R+ + A EYA NN KVT VHK NI K +G F + + RE A + Q Sbjct: 193 EGSQRLIRAAIEYALANNLTKVTLVHKGNIQKFTEGGFRKWGYELAKREYAAELASGQLV 252 Query: 807 YNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSN-VAAGIAXXXXXXXXXXXXQ-DHAV 980 ++II DN Q++ KPE+FDV+ NL G+ S+ +AA + Q HA+ Sbjct: 253 VDDIIADNFLQQILLKPERFDVVALTNLNGDYASDALAAQVGGIGISPGANINYQTGHAI 312 Query: 981 FEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRLESAVKGVIAEGKYR 1160 FE A+ G + I Q ANP ++ LS M+ ++ + +D + AV+ IA G+ Sbjct: 313 FE--ATHGTAPD--IAGQDLANPSSVLLSGCMLFDYIGWSKVSDLIMKAVEKAIANGQVT 368 Query: 1161 ---TRDLGGTS-TTQEVTDAVIAKL 1223 ++LG + TT++ ++ ++ L Sbjct: 369 IDFAKELGVEALTTRQFSEVLLTYL 393
>P96318:IDH_CALNO Isocitrate dehydrogenase [NADP] - Caldococcus noboribetus| Length = 429 Score = 131 bits (330), Expect = 6e-30 Identities = 117/388 (30%), Positives = 177/388 (45%), Gaps = 64/388 (16%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFET-----YEVHGDMPS-------VPTEVIE 386 V GDGIGP + + ++V++A T +EV + +P ++ Sbjct: 35 VAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTAGEEAQKECGSLLPDGTLQ 94 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRH---ENVDIA 557 + + +V LKG L TPVGGG SLN+ LR LDLY++ V G PT H EN+D Sbjct: 95 AFKLARVNLKGPLTTPVGGGFRSLNVTLRMVLDLYSN-VRPVKWYGQPTPHCHPENIDWV 153 Query: 558 VIRENTEGEYSGLEH--------------------EVVPGVVESLKVMTKFCSERIAKYA 677 + RENTE Y+G+E E+ P +K ++K+ ++R + A Sbjct: 154 IFRENTEDVYAGIEWPFDSPEAQKIRDFLKKEFGIELTPDTGIGIKPISKWRTQRHVRRA 213 Query: 678 FEYAYLNNRKKVTAVHKANIMKLADGLFLE---------------SCREVATKYPG---- 800 E+A N K VT +HK NIMK +G F + + EV TKY G Sbjct: 214 MEWAIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEFRDYVVTEEEVNTKYGGKAPE 273 Query: 801 --IQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH 974 I N+ I DN Q++ +P +++V+VTPNL G+ +S+ A + Sbjct: 274 GKIIVNDRIADNMLQQIITRPGEYNVIVTPNLNGDYISDEANALVGGIGMAAGLDMGDGI 333 Query: 975 AVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLR-HLQFPSFADRLESAVKGVIA 1145 AV E G++ G + I NP A LS +L + +P +E AVK IA Sbjct: 334 AVAEPVHGSAPKYAGKNVI------NPTAEILSGMYLLSDFVGWPEVKLLVEYAVKQAIA 387 Query: 1146 EGKYR---TRDLGGTS--TTQEVTDAVI 1214 + R++GG + +T E TD ++ Sbjct: 388 HKQVTYDLAREMGGVTPISTTEYTDVLV 415
>O67480:IDH_AQUAE Isocitrate dehydrogenase [NADP] - Aquifex aeolicus| Length = 426 Score = 131 bits (329), Expect = 8e-30 Identities = 106/359 (29%), Positives = 169/359 (47%), Gaps = 57/359 (15%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH------GDMPS------VPTEVIE 386 + I GDGIGP +T A+ ++ + +++ GD +P E ++ Sbjct: 41 IPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGERLPQETLD 100 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPT---RHENVDIA 557 ++ + V +KG L TPVG GV S+N LR+ D Y+++ + + G T E VD+ Sbjct: 101 VLKESIVGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPVYWM-GQATPIPNPERVDLV 159 Query: 558 VIRENTEGEYSGLEHEVVPGVVESLKV-------------------------MTKFCSER 662 V RENT+ Y+G+E G E+ KV M++F ++R Sbjct: 160 VFRENTDDVYAGVEF--FAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTKR 217 Query: 663 IAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATK-------------YPG- 800 + A YA NN+K V + K NIMK +G F+ EVA + PG Sbjct: 218 HVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVVTDPEAEPGE 277 Query: 801 --IQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH 974 ++ ++I D MQLV KPE +DV++ NL G+ VS++AA + + Sbjct: 278 GQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASLIGGPGFVPSGNIGDGY 337 Query: 975 AVFEQ-GASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRLESAVKGVIAE 1148 A+FE +A ++ I ANP++L LS AMML ++ + A ++ AV+ +AE Sbjct: 338 ALFESTHGTAWDIAGKGI-----ANPLSLTLSGAMMLEYIGWKEAAQKVYDAVRRTLAE 391
>O34295:TTUC5_AGRVI Probable tartrate dehydrogenase/decarboxylase ttuC' - Agrobacterium| vitis (Rhizobium vitis) Length = 358 Score = 130 bits (328), Expect = 1e-29 Identities = 108/351 (30%), Positives = 177/351 (50%), Gaps = 28/351 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHA-----PVCFET-------YEVHGDMPSVPTEVIE 386 + IP DGIGP V A QV+EA+ + ET Y+ HG M +P + ++ Sbjct: 6 IAAIPADGIGPEVIAAGLQVLEALEQRSGDFKIHTETFDWGSDYYKKHGVM--MPADGLD 63 Query: 387 SIRRNKVCLKGGLATP-VGGGVS--SLNLQLRKELDLYASLVNCFNLPGL--PTRH---E 542 +++ G + P V ++ L L + + D YA++ LPG+ P R+ Sbjct: 64 KLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGITPPLRNCGPG 123 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESL----KVMTKFCSERIAKYAFEYAYLNNRKK 710 ++D ++REN+EGEYSG G+ E + + T+ RI +YAF+ A RK Sbjct: 124 DLDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRKL 183 Query: 711 VTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNL 890 +T V K+N + ++ E EVAT++P + +++++VD +++ KPE D +V NL Sbjct: 184 LTVVTKSNAQRHGMVMWDEIAAEVATEFPDVTWDKMLVDAMTVRMTLKPETLDTIVATNL 243 Query: 891 YGNLVSNVAAGIAXXXXXXXXXXXXQDH---AVFEQ-GASAGNVGNDKILQQKKANPVAL 1058 + +++S++A +A + ++FE SA ++ I ANP+A Sbjct: 244 HADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGI-----ANPIAT 298 Query: 1059 FLSSAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAV 1211 F ++A ML HL A RL AV+ V E T D+GGT+ T +VT+AV Sbjct: 299 FWTAAQMLEHLGERDAAARLMGAVERV-TEAGILTPDVGGTANTSQVTEAV 348
>Q2G4X5:LEU3_NOVAD 3-isopropylmalate dehydrogenase - Novosphingobium aromaticivorans| (strain DSM 12444) Length = 352 Score = 130 bits (326), Expect = 2e-29 Identities = 117/356 (32%), Positives = 173/356 (48%), Gaps = 29/356 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM--------HAPVCFETYEVHGDMPSVPTEVIESIRR 398 + ++PGDGIGP VT +V+EA+ APV Y+ +G +P E +E R Sbjct: 3 IAVLPGDGIGPEVTREAVRVIEALGLGDIEMKEAPVGGAAYKAYGH--PLPPETLEIARL 60 Query: 399 NKVCLKGGLATPVGGGVS------SLNLQLRKELDLYASLVNCFNLPGL-------PTRH 539 + L G + P + L LRK L L+A+L G+ P Sbjct: 61 SDGILFGAVGDPDCDSLERHLRPEQAILGLRKALTLFANLRPARVFKGMEDFSALRPEVA 120 Query: 540 ENVDIAVIRENTEGEYSGLE--HEVVPGVVESLKVMTKFCSE--RIAKYAFEYAYLNNRK 707 +D+ ++RE Y G + G E VM+ SE RIA AF A + +K Sbjct: 121 GAIDLLIVRELNGDVYFGEKGFRTAANGDREGYDVMSYSESEVRRIAHVAFRAA-MGRKK 179 Query: 708 KVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPN 887 ++ +V KAN+++ + L+ + EVA YP + + VDN MQLV P FDV+VT N Sbjct: 180 RLCSVDKANVLETSQ-LWRDVMLEVAKDYPEVALEHMYVDNAAMQLVRAPGNFDVVVTGN 238 Query: 888 LYGNLVSNVAA---GIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVAL 1058 L+G+++S+ A+ G ++ F D I + ANP+A Sbjct: 239 LFGDILSDQASMCVGSIGLLASASLGERETEYGTFGLYEPIHGSAPD-IAGKGLANPMAT 297 Query: 1059 FLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 LS+AM+LRH L ADR+E+AV +A+G RDLGGT+ T E+ DAV+A+L Sbjct: 298 ILSAAMLLRHSLGLEVAADRIEAAVAKALADG-VLGRDLGGTAGTTEIGDAVLARL 352
>Q5LWZ5:LEU3_SILPO 3-isopropylmalate dehydrogenase - Silicibacter pomeroyi| Length = 367 Score = 129 bits (325), Expect = 2e-29 Identities = 117/369 (31%), Positives = 187/369 (50%), Gaps = 40/369 (10%) Frame = +3 Query: 240 TVTLIPGDGIGPLVTGAVRQVM-----------EAMHAPVCFETYEVHGDMPSVPTEVIE 386 ++ ++PGDGIGP V VR+++ + V Y+VHG + E + Sbjct: 5 SLLILPGDGIGPEVMAEVRKIIGWFGDKRGLNFDVSEDLVGGAAYDVHG--VPLADETMA 62 Query: 387 SIRRNKVCLKGGLATPVGGGVS-SLN-----LQLRKELDLYASL--VNCFN-LPGLPTRH 539 + L G + P + S+ L+LRKE+DL+++L CF+ L + Sbjct: 63 KAQEADAVLLGAVGGPKYDDLDFSVKPERGLLRLRKEMDLFSNLRPAQCFDALADFSSLK 122 Query: 540 ENV----DIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSE----RIAKYAFEYAYL 695 +++ DI ++RE T G Y G + E + + T+ +E R+A+ AFE A + Sbjct: 123 KDIVAGLDIMIVRELTSGVYFGEPRGIFEEGNERVGINTQRYTESEIERVARSAFELA-M 181 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ ++ KAN+M+ + L+ E VA YP ++ + + DN MQLV P+QFDV+ Sbjct: 182 RRSKKLCSMEKANVME-SGILWREVVTRVAKDYPEVELSHMYADNGAMQLVRAPKQFDVI 240 Query: 876 VTPNLYGNLVSNVAA------GIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQK 1037 +T NL+G+++S+ AA G+ + A++E + I Q Sbjct: 241 LTDNLFGDILSDCAAMLTGSLGMLPSASLGAPMANGRPKALYEPVHGSA----PDIAGQG 296 Query: 1038 KANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS-----TTQEV 1199 KANP+A LS AM LR+ + ADRLE+AV+ V+A+G RT DL GT +T E+ Sbjct: 297 KANPIACILSFAMALRYSFDQGAEADRLEAAVEQVLADG-VRTADLLGTEGVTPVSTTEM 355 Query: 1200 TDAVIAKLD 1226 A++AKLD Sbjct: 356 GAAILAKLD 364
>Q47SB4:LEU3_THEFY 3-isopropylmalate dehydrogenase - Thermobifida fusca (strain YX)| Length = 354 Score = 129 bits (324), Expect = 3e-29 Identities = 109/343 (31%), Positives = 165/343 (48%), Gaps = 24/343 (6%) Frame = +3 Query: 237 RTVTL--IPGDGIGPLVTGAVRQVMEAMHAP---VCFETYEV-------HGDMPSVPTEV 380 RTV L IPGDGIGP V +V+ A+ AP + +T E H +P V Sbjct: 4 RTVKLAVIPGDGIGPEVVAEGLKVLSAV-APRHGLTLDTTEYELGAQRWHATGEVLPDAV 62 Query: 381 IESIRRNKVCLKGGLATP-VGGGV--SSLNLQLRKELDLYASLVNCFNLPGLPT-----R 536 E +R++ L G + P V GV L L+LR Y +L PG+ T Sbjct: 63 EEELRQHDAILLGAVGDPTVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGVA 122 Query: 537 HENVDIAVIRENTEGEYSGLEHEVVPGVVESL----KVMTKFCSERIAKYAFEYAYLNNR 704 E++D+ V+RE TEG Y+G+ + G + V T+ ER+ +YAF A Sbjct: 123 PEDIDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVERVVRYAFAKAAERPC 182 Query: 705 KKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTP 884 K+T VHK N++ A L+ REV +YP ++ + + VD M V +P +FDV+VT Sbjct: 183 HKLTLVHKDNVLTYAGELWQRVVREVGAEYPQVEVDYLHVDAATMFFVTQPRRFDVVVTD 242 Query: 885 NLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFL 1064 NL+G++++++ A +A + F + I Q KA+P A L Sbjct: 243 NLFGDIITDLGAAVAGGIGLAASGNINPE-GDFPSMFEPVHGSAPDIAGQGKADPTATIL 301 Query: 1065 SSAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQ 1193 S ++ML HL + A +++ AV + E R ++ G STTQ Sbjct: 302 SVSLMLEHLGYADAAAQIDQAVAEDLQE---RAKNGGVRSTTQ 341
>P12010:LEU3_BACCO 3-isopropylmalate dehydrogenase - Bacillus coagulans| Length = 366 Score = 129 bits (324), Expect = 3e-29 Identities = 121/361 (33%), Positives = 184/361 (50%), Gaps = 33/361 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----HAPVCFETYEVHGDM-----PSVPTEVIESI 392 + ++PGDGIGP V A +V++ + H V FE + G +P E ++ Sbjct: 5 LAVLPGDGIGPEVMDAAIRVLKTVLDNDGHEAV-FENALIGGAAIDEAGTPLPEETLDIC 63 Query: 393 RRNKVCLKGGLATPVGG-GVSSLN-----LQLRKELDLYASL------VNCFNLPGLPT- 533 RR+ L G + P +SL L LRKE+ L+A+L N L Sbjct: 64 RRSDAILLGAVGGPKWDHNPASLRPEKGLLGLRKEMGLFANLRPVKAYATLLNASPLKRE 123 Query: 534 RHENVDIAVIRENTEGEYSGLEHEVV-PG---VVESLKVMTKFCSERIAKYAFEYAYLNN 701 R ENVD+ ++RE T G Y G E PG VV++L T+ ERI + AF+ A + Sbjct: 124 RVENVDLVIVRELTGGLYFGRPSERRGPGENEVVDTL-AYTREEIERIIEKAFQLAQIR- 181 Query: 702 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 RKK+ +V KAN+++ + ++ E E A KYP ++ + ++VD+ MQL+A P QFDV+VT Sbjct: 182 RKKLASVDKANVLE-SSRMWREIAEETAKKYPDVELSHMLVDSTSMQLIANPGQFDVIVT 240 Query: 882 PNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQGASAGNVGNDKILQQKKANPVAL 1058 N++G+++S+ A+ I D ++E + I Q KANP+ Sbjct: 241 ENMFGDILSDEASVITGSLGMLPSASLRSDRFGMYEPVHGSA----PDIAGQGKANPLGT 296 Query: 1059 FLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL----GGTSTTQEVTDAVIAKL 1223 LS+A+MLR+ A +E AV V+ +G Y T DL G +T E+TD +I KL Sbjct: 297 VLSAALMLRYSFGLEKEAAAIEKAVDDVLQDG-YCTGDLQVANGKVVSTIELTDRLIEKL 355 Query: 1224 D 1226 + Sbjct: 356 N 356
>Q6AEP6:LEU3_LEIXX 3-isopropylmalate dehydrogenase - Leifsonia xyli subsp. xyli| Length = 357 Score = 128 bits (321), Expect = 7e-29 Identities = 109/357 (30%), Positives = 172/357 (48%), Gaps = 30/357 (8%) Frame = +3 Query: 237 RTVTL--IPGDGIGPLVTGAVRQVMEAMHA-----------PVCFETYEVHGDMPSVPTE 377 RTV L IPGDGIGP V + ++A+ A + + Y GD+ + + Sbjct: 3 RTVQLVVIPGDGIGPEVIAEAVKALDAVTAGSGLAFQKTYFSLGADRYLATGDV--LTDD 60 Query: 378 VIESIRRNKVCLKGGLATPVG----GGVS---SLNLQLRKELDLYASLVNCFNLPGLPT- 533 + +IR + L G + G G + L L+LR LD Y +L PG+ + Sbjct: 61 DLAAIRGHDAILLGAVGGRPGDPRLAGANVERGLLLRLRFSLDHYVNLRPTTLFPGIASP 120 Query: 534 --RHENVDIAVIRENTEGEYSGLEHEVVPG----VVESLKVMTKFCSERIAKYAFEYAYL 695 VD V+RE TEG+Y G + PG V + V T + ER+ +YAFE A Sbjct: 121 LAAPGEVDFVVVREGTEGQYVGNGGAIRPGTPHEVANEVSVNTAYGVERVVRYAFEQAG- 179 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 RKK+T VHK N++ A L+ +A ++P + + + VD + LV P +FDV+ Sbjct: 180 QRRKKLTLVHKTNVLTFAGSLWKRIVDALAAEHPEVAVDYLHVDAATIFLVTDPARFDVI 239 Query: 876 VTPNLYGNLVSNVAAGIA---XXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKAN 1046 VT NL+G++++++AA I+ + ++FE + I +++A+ Sbjct: 240 VTDNLFGDILTDLAAAISGGIGLAASGNINPVGEFPSMFEPVHGSA----PDIAGEQRAD 295 Query: 1047 PVALFLSSAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIA 1217 P A LS A++LRHL A+R+E AV +A + T TT ++ DA+ A Sbjct: 296 PTAAILSVALLLRHLGERPLAERVERAVTTDLAARSGQMATASQTRTTSQIGDAIAA 352
>P41560:IDH1_COLMA Isocitrate dehydrogenase [NADP] 1 - Colwellia maris (Vibrio sp.| (strain ABE-1)) Length = 415 Score = 128 bits (321), Expect = 7e-29 Identities = 108/360 (30%), Positives = 166/360 (46%), Gaps = 60/360 (16%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVC-----FETYEVHGDMPS---------VPTEV 380 + I GDGIG VT + +V+ A A E EV+ + +P E Sbjct: 29 IPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYDSETWLPEET 88 Query: 381 IESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPT---RHENVD 551 + ++ KV +KG L TPVGGG+SSLN+ +R+ LDLY G+P+ R VD Sbjct: 89 LNILQEYKVSIKGPLTTPVGGGMSSLNVAIRQMLDLYVCQRPVQWFTGVPSPVKRPSEVD 148 Query: 552 IAVIRENTEGEYSGLEHE--------VVPGVVE---------------SLKVMTKFCSER 662 + + RENTE Y+G+E++ V+ ++E +K ++K S+R Sbjct: 149 MVIFRENTEDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFTENCGIGIKPVSKEGSQR 208 Query: 663 IAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPG-------------- 800 + + A +YA NN+ VT VHK NIMK +G F + E+A + G Sbjct: 209 LVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAIEEFGASLLHGGPWCSLKN 268 Query: 801 ------IQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXX 962 I ++I D Q++ +P ++ V+ T NL G+ +S+ A Sbjct: 269 PNTGKEIIIKDVIADAMLQQVLLRPAEYSVIATLNLNGDYLSDALAAQVGGIGIAPGANL 328 Query: 963 XQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRLESAVKGVI 1142 + AVFE A+ G K + K NP ++ LS+ MMLRH+ + AD L + G I Sbjct: 329 GDEVAVFE--ATHGTA--PKYAGKNKVNPGSVILSAEMMLRHMGWLE-ADLLLKGMSGAI 383
>Q8RDK0:LEU3_THETN 3-isopropylmalate dehydrogenase - Thermoanaerobacter tengcongensis| Length = 355 Score = 126 bits (317), Expect = 2e-28 Identities = 115/357 (32%), Positives = 171/357 (47%), Gaps = 33/357 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHA-----------PVCFETYEVHGDMPSVPTEVIES 389 + ++PGDGIGP V +V++A+ P E + +G+ P E Sbjct: 4 IAVLPGDGIGPEVIEEGLKVLKAVEEKYGLRFDIKKYPFGGEAIDKYGE--PYPEETRNG 61 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL----PTRH 539 + L G + P G+ L LRK L +YA+L P L P ++ Sbjct: 62 CLSSDAVLLGAVGGPKWDGLEGDKRPEAGLLALRKSLGVYANLRPAVLYPSLKDASPLKN 121 Query: 540 E----NVDIAVIRENTEGEYSGLEHEVVPGV---VESLKVMTKFCSERIAKYAFEYAYLN 698 E +DI V+RE T G Y G + G +V ERIA AFE A L Sbjct: 122 ELLEKGLDILVVRELTGGIYFGPRGKEAIGYGFRAYDTEVYETQEIERIAVIAFEAA-LR 180 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 RKK+T+V KAN+++ + L+ ++ EVA +YP ++ N + VDNC MQLV P QFDV++ Sbjct: 181 RRKKITSVDKANVLE-SSRLWRKTVEEVAKRYPEVELNHMYVDNCAMQLVKNPFQFDVIL 239 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ--GASAGNVGNDKILQQKKANPV 1052 T N++G+++S+ AA I D + SA ++ KI ANP+ Sbjct: 240 TNNMFGDILSDEAAQIVGSIGILPSASLRGDRVGLYEPIHGSAPDIAGKKI-----ANPL 294 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGG--TSTTQEVTDAVI 1214 A LS AMML++ A + AV+ + EG +RT DLG +T+E+ D V+ Sbjct: 295 ATILSVAMMLQYSFGEEEAAQDIRKAVERALEEG-FRTADLGKGIVLSTEEMGDKVV 350
>P94631:LEU3_CORGL 3-isopropylmalate dehydrogenase - Corynebacterium glutamicum| (Brevibacterium flavum) Length = 340 Score = 126 bits (317), Expect = 2e-28 Identities = 104/349 (29%), Positives = 169/349 (48%), Gaps = 22/349 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV-------HGDMPSVPTEVIESIRRN 401 + +I GDGIGP VT +V+ A+ + Y++ +G++ + E + S+R + Sbjct: 3 LAVIGGDGIGPEVTAEALKVLNAVRDDIETTDYDLGARRYLKNGEL--LTDEDLASLREH 60 Query: 402 KVCLKGGLATP--VGGGV--SSLNLQLRKELDLYASLVNCFNLPGLPTRHEN---VDIAV 560 L G + P V G+ L L++R LD + +L G+ + N +D V Sbjct: 61 DAILLGAIGAPGSVPPGILERGLLLKMRFALDHHVNLRPSKLYDGVESPLRNPGKIDFVV 120 Query: 561 IRENTEGEYSGLEHEVVPG----VVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHK 728 +RE TEG Y+G + G + V T++ +ER+ +YAFE A + RKK+T VHK Sbjct: 121 VREGTEGAYTGNGGAIRVGTPHEIANETSVNTRYGAERVIRYAFELAQ-SRRKKLTLVHK 179 Query: 729 ANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVS 908 N++ GL+ + EVA +YP + + +D + LV P +FDV+VT NL+G++++ Sbjct: 180 TNVLVHGGGLWQRTVDEVAKEYPEVAVDYNHIDAATIYLVTDPSRFDVIVTDNLFGDILT 239 Query: 909 N----VAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAM 1076 + V+ GI SA ++ I A+P A LS+AM Sbjct: 240 DEAGAVSGGIGLAASGNIDATGTNPSMFEPVHGSAPDIAGQGI-----ADPTAAILSAAM 294 Query: 1077 MLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 +LRHL A R+E+A+ +A RD +T EV D ++ L Sbjct: 295 LLRHLGDEDNAVRIETAIAADVA-----GRDNSQPISTTEVGDRIVKAL 338
>P39126:IDH_BACSU Isocitrate dehydrogenase [NADP] - Bacillus subtilis| Length = 423 Score = 126 bits (317), Expect = 2e-28 Identities = 107/378 (28%), Positives = 165/378 (43%), Gaps = 77/378 (20%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM--------------HAPVCFETYEVHGDMPSVPTEV 380 + I GDG GP + A +V+EA + Y G+ +P E Sbjct: 22 IPFIEGDGTGPDIWNAASKVLEAAVEKAYKGEKKITWKEVYAGEKAYNKTGEW--LPAET 79 Query: 381 IESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPT---RHENVD 551 ++ IR + +KG L TPVGGG+ SLN+ LR+ELDL+ L G+P+ R E+ D Sbjct: 80 LDVIREYFIAIKGPLTTPVGGGIRSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTD 139 Query: 552 IAVIRENTEGEYSGLEH----EVVPGVVE-------------------SLKVMTKFCSER 662 + + RENTE Y+G+E+ E V ++ +K +++ + R Sbjct: 140 MVIFRENTEDIYAGIEYAKGSEEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSR 199 Query: 663 IAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPG------IQYNEI-- 818 + + A +YA + RK VT VHK NIMK +G F E+A K G QY+ I Sbjct: 200 LVRAAIDYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAE 259 Query: 819 -------------------------IVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAG 923 I D Q++ +P +FDV+ T NL G+ +S+ A Sbjct: 260 EQGKDAANKAQSEAEAAGKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAA 319 Query: 924 IAXXXXXXXXXXXXQD--HAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHL 1091 + HA+FE G + G DK+ NP ++ LS ++L HL Sbjct: 320 QVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLDKV------NPSSVILSGVLLLEHL 373 Query: 1092 QFPSFADRLESAVKGVIA 1145 + AD + +++ IA Sbjct: 374 GWNEAADLVIKSMEKTIA 391
>Q2JTN8:LEU3_SYNJA 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain JA-3-3Ab)| (Cyanobacteria bacterium Yellowstone A-Prime) Length = 381 Score = 126 bits (316), Expect = 3e-28 Identities = 115/364 (31%), Positives = 175/364 (48%), Gaps = 37/364 (10%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE-----------TYEVHGDMPSVPTEVIES 389 +T + GDGIGP + R V++A+ A V F YE GD +P E ++ Sbjct: 13 ITALAGDGIGPEIMQVGRAVLDAVAAQVGFSLQWQEGLIGGAAYEATGD--PLPPETLKM 70 Query: 390 IRRNKVCLKGGLAT------PVGGGVSSLNLQLRKELDLYASLVNCFNLPGL-------P 530 + + + P L LR L L+A+L P L P Sbjct: 71 AQESDAVYLAAVGDFKYDTLPREKRPERALLGLRAGLGLFANLRPVKIFPQLVQASSLKP 130 Query: 531 TRHENVDIAVIRENTEGEYSGLEHEVVPGVVESLK-VMTKFCSE----RIAKYAFEYAYL 695 +D+ V+RE T G Y G + S + V T SE RIA+ AFE A Sbjct: 131 EVVAGIDLVVVRELTGGIYFGQPKGIFTDAKGSRRGVNTMAYSEAEVDRIARVAFELAR- 189 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 R+K+ +V KAN+++++ L+ E +A +YP ++ + + VDN MQLV P+QFDV+ Sbjct: 190 KRRRKLCSVDKANVLEVSQ-LWRERVTAIAAEYPDVELSHLYVDNAAMQLVRWPKQFDVI 248 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQKKAN 1046 +T NL+G+++S+ AA + V+E G++ G D KAN Sbjct: 249 LTENLFGDILSDEAAMLTGSIGMLPSASLGSSGPGVYEPVHGSAPDIAGQD------KAN 302 Query: 1047 PVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTT----QEVTDAV 1211 P+A LS AM+LR+ L P ADR+E AV+ V+A+G YRT D+ T +E+ + + Sbjct: 303 PIAQVLSGAMLLRYSLDQPQAADRIEQAVEAVLAQG-YRTADIYSEGMTLVGCREMGEKI 361 Query: 1212 IAKL 1223 +A L Sbjct: 362 LAAL 365
>Q21IY5:LEU3_SACD2 3-isopropylmalate dehydrogenase - Saccharophagus degradans (strain| 2-40 / ATCC 43961 / DSM 17024) Length = 357 Score = 126 bits (316), Expect = 3e-28 Identities = 114/363 (31%), Positives = 178/363 (49%), Gaps = 34/363 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAP----VCFETYEVHG---DMPSVPT--EVIES 389 + + L+PGDGIGP + ++V+EA+ A + FE + G D+ VP ++ Sbjct: 3 KKIVLLPGDGIGPEIVAEAKKVLEAVDAKFKLGLKFEEDLIGGCAIDVHGVPLAQSTLDR 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------P 530 + L G + P + S L++R E+ LYA+L P L P Sbjct: 63 CKAADAVLMGSVGGPKWDALDSNIRPEKGLLKIRYEMGLYANLRPAILYPQLADASSLKP 122 Query: 531 TRHENVDIAVIRENTEGEYSG-------LEHEVVPGVVESLKVMTKFCSERIAKYAFEYA 689 +DI ++RE T G Y G L++ G + V + ERI + AFE A Sbjct: 123 EIVSGLDILIVRELTGGIYFGEPRGIRLLDNGERQGY--NTYVYAEHEIERIGRTAFEMA 180 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD 869 + KKV +V KAN+++ A L+ E + ++ YP ++ + + VDN MQLV P+QFD Sbjct: 181 -MKRDKKVCSVDKANVLE-ATVLWREVIQSISKDYPEVELSHMYVDNAAMQLVRAPKQFD 238 Query: 870 VMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANP 1049 V+VT N++G+++S+ AA + QD + I Q ANP Sbjct: 239 VVVTGNMFGDILSDTAAMLTGSIGMLPSASLNQDSKGLYEPVHG---SAPDIAGQGVANP 295 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS----TTQEVTDAVI 1214 +A LS+AMMLR+ L + AD +E+AV V+ +G R+ D+ +TQE+ DAV Sbjct: 296 LATILSAAMMLRYSLNEAAAADAIEAAVGAVLDDG-LRSADIFSEGMKKVSTQEMGDAVA 354 Query: 1215 AKL 1223 AK+ Sbjct: 355 AKI 357
>P94929:LEU3_MYCBO 3-isopropylmalate dehydrogenase - Mycobacterium bovis| Length = 336 Score = 125 bits (314), Expect = 5e-28 Identities = 103/333 (30%), Positives = 162/333 (48%), Gaps = 22/333 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV-----HGDMPSVPTEVIESIRRNKV 407 + +I GDGIGP VT +V++A+ V +Y++ H +P V+ +R + Sbjct: 3 LAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDA 62 Query: 408 CLKGGLATP-VGGGV--SSLNLQLRKELDLYASLVNCFNLPGLPTR---HENVDIAVIRE 569 L G + P V GV L L+LR ELD + +L PG+ + + +D V+RE Sbjct: 63 ILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVRE 122 Query: 570 NTEGEYSGLEHEVVPG----VVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANI 737 TEG Y+G + G V + V T F R+ AFE A RK +T VHK N+ Sbjct: 123 GTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVADAFERAR-RRRKHLTLVHKTNV 181 Query: 738 MKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVA 917 + LA GL+L + EV YP ++ VD + ++ P +FDV+VT NL+G++++++A Sbjct: 182 LTLAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDLA 241 Query: 918 AGIAXXXXXXXXXXXXQDHA---VFEQ-GASAGNVGNDKILQQKKANPVALFLSSAMMLR 1085 A + A +FE SA ++ I A+P A +S A++L Sbjct: 242 AAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGI-----ADPTAAIMSVALLLS 296 Query: 1086 HLQFPSFADRLESAVKGVIA---EGKYRTRDLG 1175 HL A R++ AV+ +A + T D+G Sbjct: 297 HLGEHDAAARVDRAVEAHLATRGSERLATSDVG 329
>Q9ZN36:IDH_HELPJ Isocitrate dehydrogenase [NADP] - Helicobacter pylori J99| (Campylobacter pylori J99) Length = 425 Score = 124 bits (312), Expect = 8e-28 Identities = 102/372 (27%), Positives = 164/372 (44%), Gaps = 68/372 (18%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVM-----------------EAMHAPVCFETYEVHGDMPS-- 365 + I GDGIG +T A+ +V+ E C++ ++ H ++ Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEE 91 Query: 366 --VPTEVIESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASL--VNCFNLPGLPT 533 + + IE+I KV +KG L TP+G G SLN+ LR+++DLY L V + P Sbjct: 92 QWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVK 151 Query: 534 RHENVDIAVIRENTEGEYSGLEHEVVPGVVESL-----------------------KVMT 644 + VD+ + REN+E Y+G+E + + L K ++ Sbjct: 152 EPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRFPESSGVGIKPIS 211 Query: 645 KFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFL---------ESCREVATKYP 797 K +ER+ + A EYA N++ VT VHK NIMK +G F+ E +V K P Sbjct: 212 KEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFNAQVIDKGP 271 Query: 798 -----------GIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXXX 944 I ++I D Q++ +P ++ V+ T NL G+ +S+ A + Sbjct: 272 WCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAAMVGGIGI 331 Query: 945 XXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRL 1118 +FE G + G DK+ NP ++ LS+ MMLRH+ + AD + Sbjct: 332 APGANLNDTVGMFEATHGTAPKYAGLDKV------NPGSIILSAEMMLRHMGWVEAADLI 385 Query: 1119 ESAVKGVIAEGK 1154 SA++ I K Sbjct: 386 VSAMEKAIKSKK 397
>Q56268:LEU3_THIFE 3-isopropylmalate dehydrogenase - Thiobacillus ferrooxidans| (Acidithiobacillus ferrooxidans) Length = 358 Score = 124 bits (311), Expect = 1e-27 Identities = 110/346 (31%), Positives = 163/346 (47%), Gaps = 29/346 (8%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPV-----CFETY----EVHGDMPSVPTEVIES 389 + + + GDGIGP + A RQV++A+ C E + +P ++ Sbjct: 2 KKIAIFAGDGIGPEIVAAARQVLDAVDQAAHLGLRCTEGLVGGAALDASDDPLPAASLQL 61 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL----PTRH 539 + G + P L+LRK LDLYA+L P L P R Sbjct: 62 AMAADAVILGAVGGPRWDAYPPAKRPEQGLLRLRKGLDLYANLRPAQIFPQLLDASPLRP 121 Query: 540 E---NVDIAVIRENTEGEYSGLEH--EVVPGVVESLKVMTKFCSE--RIAKYAFEYAYLN 698 E +VDI V+RE T Y G EV+ G M E RIA AF A Sbjct: 122 ELVRDVDILVVRELTGDIYFGQPRGLEVIDGKRRGFNTMVYDEDEIRRIAHVAFRAAQ-G 180 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 RK++ +V KAN+++ L+ E EVA YP ++ + + VDN MQL+ P QFDV++ Sbjct: 181 RRKQLCSVDKANVLETTR-LWREVVTEVARDYPDVRLSHMYVDNAAMQLIRAPAQFDVLL 239 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPV 1052 T N++G+++S+ A+ + + A++E G++ G D KANP+ Sbjct: 240 TGNMFGDILSDEASQLTGSIGMLPSASLGEGRAMYEPIHGSAPDIAGQD------KANPL 293 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST 1187 A LS AMMLRH L +A R+E+AV+ V+ +G RT D+ T Sbjct: 294 ATILSVAMMLRHSLNAEPWAQRVEAAVQRVLDQG-LRTADIAAPGT 338
>Q5WEN4:LEU3_BACSK 3-isopropylmalate dehydrogenase - Bacillus clausii (strain KSM-K16)| Length = 364 Score = 124 bits (311), Expect = 1e-27 Identities = 115/364 (31%), Positives = 180/364 (49%), Gaps = 35/364 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAM----HAPVCFETYEVHGDM-----PSVPTEVIES 389 + + L+PGDGIGP + ++V+E + H F + GD +P E ++ Sbjct: 3 KQILLLPGDGIGPEIIAETKRVLEEIARLYHHTFQFVEGRIGGDAIDATGSPLPEETLDL 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASL--VNCFN-LPGLPTRHE 542 + + L G + P G + LQ+RK L LYA+L V L G T E Sbjct: 63 AKGSDAILLGAVGGPKWDGNAPEKRPEKGLLQIRKALGLYANLRPVRVLKPLMGASTLKE 122 Query: 543 ----NVDIAVIRENTEGEYSGLEHEV-----VPGVVESLKVMTKFCSERIAKYAFEYAYL 695 +VD+ ++RE T G Y G E G V++L + T+ ERI AF++A Sbjct: 123 EVLADVDLLIVRELTGGLYFGEPRERRQINGEDGAVDTL-LYTRGEIERIVHQAFQFAR- 180 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 +K+V +V KAN+++ + L+ E EVA +YP + + ++VDN MQL+ P QFDV+ Sbjct: 181 TRKKRVVSVDKANVLE-SSRLWREIADEVAREYPDVTLSHMLVDNAAMQLIRDPRQFDVI 239 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFE--QGASAGNVGNDKILQQKKAN 1046 VT NL+G+++S+ A+ I +FE G++ G AN Sbjct: 240 VTENLFGDILSDEASMITGSLGLLPSASMNTSKVGLFEPVHGSAPDIAGTG------AAN 293 Query: 1047 PVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS----TTQEVTDAV 1211 P+A LS+AMML++ A +E AV V+A+G RT+D+ S +T +T+AV Sbjct: 294 PLATILSAAMMLQYSFGLADEAKAIEVAVDRVLAQG-VRTKDIAKASENAVSTTAITNAV 352 Query: 1212 IAKL 1223 + L Sbjct: 353 MEAL 356
>O86504:LEU3_STRCO 3-isopropylmalate dehydrogenase - Streptomyces coelicolor| Length = 347 Score = 124 bits (310), Expect = 1e-27 Identities = 107/349 (30%), Positives = 164/349 (46%), Gaps = 22/349 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEA-MHAPVCFETYEV-------HGDMPSVPTEVIESIRR 398 + +IPGDGIG V +V+ A + V ET E H ++ +++++ Sbjct: 7 LAVIPGDGIGQEVVAEGLKVLSAVLPQDVKLETKEFDFGARRYHATGETLTDADLDALKA 66 Query: 399 NKVCLKGGLATP-VGGGVSSLN--LQLRKELDLYASLVNCFNLPGLPTR---HENVDIAV 560 + L G + P V GV L+LR D + +L LPG+ T +D V Sbjct: 67 HDAILLGAIGDPSVPSGVLERGFLLKLRFAFDHHVNLRPSKLLPGVATPLAGQPEIDFVV 126 Query: 561 IRENTEGEYSG--------LEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVT 716 +RE TEG Y+G EHEV V V T + ER+ + AF A RKK+T Sbjct: 127 VREGTEGPYTGNGGTIRKGTEHEVATEV----SVNTAYGVERVVRDAFARAQARPRKKLT 182 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 VHK N++ A L+ +VA +YP + + + VD + LV P +FDV+VT NL+G Sbjct: 183 LVHKNNVLTFAGHLWTNIFNKVAAEYPEVTTDYLHVDAATIFLVTDPARFDVIVTDNLFG 242 Query: 897 NLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAM 1076 ++++++AA ++ F + I Q KA+P A LS A+ Sbjct: 243 DIITDLAAAVS-GGIGVAASGNINPSGDFPSMFEPVHGSAPDIAGQGKADPTATVLSVAL 301 Query: 1077 MLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 +LRHL + A R+E AV + E DL ST+ E+ D + A++ Sbjct: 302 LLRHLGYEDEAARIEDAVSADLGE----RGDLPARSTS-EIGDTLAARV 345
>P95313:LEU3_MYCTU 3-isopropylmalate dehydrogenase - Mycobacterium tuberculosis| Length = 336 Score = 124 bits (310), Expect = 1e-27 Identities = 102/333 (30%), Positives = 161/333 (48%), Gaps = 22/333 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV-----HGDMPSVPTEVIESIRRNKV 407 + +I GDGIGP VT +V++A+ V +Y++ H +P V+ +R + Sbjct: 3 LAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDA 62 Query: 408 CLKGGLATP-VGGGV--SSLNLQLRKELDLYASLVNCFNLPGLPTR---HENVDIAVIRE 569 L G + P V GV L L+LR ELD + +L PG+ + + +D V+RE Sbjct: 63 ILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVRE 122 Query: 570 NTEGEYSGLEHEVVPG----VVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANI 737 TEG Y+G + G V + V T F R+ AFE A RK +T VHK N+ Sbjct: 123 GTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVADAFERAR-RRRKHLTLVHKTNV 181 Query: 738 MKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVA 917 + A GL+L + EV YP ++ VD + ++ P +FDV+VT NL+G++++++A Sbjct: 182 LTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDLA 241 Query: 918 AGIAXXXXXXXXXXXXQDHA---VFEQ-GASAGNVGNDKILQQKKANPVALFLSSAMMLR 1085 A + A +FE SA ++ I A+P A +S A++L Sbjct: 242 AAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGI-----ADPTAAIMSVALLLS 296 Query: 1086 HLQFPSFADRLESAVKGVIA---EGKYRTRDLG 1175 HL A R++ AV+ +A + T D+G Sbjct: 297 HLGEHDAAARVDRAVEAHLATRGSERLATSDVG 329
>Q9WZ26:LEU3_THEMA 3-isopropylmalate dehydrogenase - Thermotoga maritima| Length = 354 Score = 123 bits (309), Expect = 2e-27 Identities = 113/360 (31%), Positives = 171/360 (47%), Gaps = 32/360 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYE-----VHGDMPSVPTEVIESIRRNKV 407 + ++PGDGIGP V +V+E + +T+E + GD E + K+ Sbjct: 3 IAVLPGDGIGPEVVREALKVLEVVEKKTG-KTFEKVFGHIGGDAIDRFGEPLPE-ETKKI 60 Query: 408 CLKGG--LATPVGGG------------VSSLNLQLRKELDLYASLVNCFNLPGL----PT 533 CL+ VGG + L L LRK L+LYA++ L P Sbjct: 61 CLEADAIFLGSVGGPKWDDLPPEKRPEIGGL-LALRKMLNLYANIRPIKVYRSLVHVSPL 119 Query: 534 RHE----NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNN 701 + + VD+ +RE + G Y G + + + ERIA+ AFE A N Sbjct: 120 KEKVIGSGVDLVTVRELSYGVYYGQPRGLDEEKGFDTMIYDRKTVERIARTAFEIAK-NR 178 Query: 702 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 RKKVT+V KAN++ + L+ + EVA +YP ++ I VDN MQL+ KP QFDV++T Sbjct: 179 RKKVTSVDKANVL-YSSMLWRKVVNEVAREYPDVELTHIYVDNAAMQLILKPSQFDVILT 237 Query: 882 PNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALF 1061 N++G+++S+ +A + + G SA ++ I ANP+A Sbjct: 238 TNMFGDILSDESAALPGSLGLLPSASFGDKNLYEPAGGSAPDIAGKNI-----ANPIAQI 292 Query: 1062 LSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLG----GTSTTQEVTDAVIAKLD 1226 LS AMML H A ++E AV+ VI EG YRTRD+ +T ++ D + KL+ Sbjct: 293 LSLAMMLEHSFGMVEEARKIERAVELVIEEG-YRTRDIAEDPEKAVSTSQMGDLICKKLE 351
>Q82JN6:LEU3_STRAW 3-isopropylmalate dehydrogenase - Streptomyces avermitilis| Length = 347 Score = 123 bits (309), Expect = 2e-27 Identities = 101/345 (29%), Positives = 166/345 (48%), Gaps = 18/345 (5%) Frame = +3 Query: 243 VTLIPGDGIGP-LVTGAVRQVMEAMHAPVCFETYEV-------HGDMPSVPTEVIESIRR 398 + +IPGDGIG +V ++ + A+ + V ET E H ++ ++++++ Sbjct: 7 LAVIPGDGIGQEVVAQGLKVLSAALPSDVKLETKEFDFGARRYHATGETLTDADLDALKQ 66 Query: 399 NKVCLKGGLATP-VGGGVSSLN--LQLRKELDLYASLVNCFNLPGLPTR---HENVDIAV 560 + L G + P V GV L+LR D + +L LPG+ T +D V Sbjct: 67 HDAILLGAIGDPSVPSGVLERGFLLKLRFAFDHHVNLRPSKLLPGVETPLAGQPEIDFVV 126 Query: 561 IRENTEGEYSGLEHEVVPG----VVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHK 728 +RE TEG Y+G + G V + + T F ER+ + A+ A RKK+ VHK Sbjct: 127 VREGTEGPYTGNGGTIRTGTPHAVATEVSLNTAFGIERVVRDAYARAQARPRKKLALVHK 186 Query: 729 ANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVS 908 N++ A L+ + +V ++P + + VD + LV +PE+FDV+VT NL+G++++ Sbjct: 187 NNVLVHAGHLWTDIFNKVGEEFPDVTTEYMHVDAATIYLVTQPERFDVIVTDNLFGDIIT 246 Query: 909 NVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLRH 1088 ++AA I+ A D I Q KA+P A LS A++LRH Sbjct: 247 DLAAAISGGIGVAASGNINPSGAYPSMFEPVHGSAPD-IAGQGKADPSATILSVALLLRH 305 Query: 1089 LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 L + + A R+E AV +AE R +T E+ DA+ ++ Sbjct: 306 LGYEAEAARIEEAVSADLAE-----RVGKPARSTDEIGDALTVRV 345
>Q4JUQ0:LEU3_CORJK 3-isopropylmalate dehydrogenase - Corynebacterium jeikeium (strain| K411) Length = 338 Score = 123 bits (309), Expect = 2e-27 Identities = 110/353 (31%), Positives = 177/353 (50%), Gaps = 26/353 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV-------HGDMPSVPTEVIESIRRN 401 + +I GDGIG VT +V+ A+ V Y++ +G++ + E ++S+R + Sbjct: 3 LAVIAGDGIGTEVTAEALKVLHALRDDVETTDYDLGARRYLRNGEL--LTDEDLDSLREH 60 Query: 402 KVCLKGGLATP--VGGGV--SSLNLQLRKELDLYASLVNCFNLPGLPTRHEN---VDIAV 560 L G + P V GV L L LR +LD +L PG + N +D V Sbjct: 61 DAILLGAIGDPRTVPAGVLERGLLLPLRFKLDHAVNLRPSKLYPGSSSPLANPGDIDFVV 120 Query: 561 IRENTEGEY--------SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVT 716 +RE TEG Y +G ++EV V ++ T + ER+ + AFE A + RKK+T Sbjct: 121 VREGTEGLYCGNGGTLRAGTDYEVASEVSQN----TYYGVERVVRDAFERAQ-SRRKKLT 175 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 VHK N++ A L+ + V +YP +Q + +D + +V KP+++DV+VT NL+G Sbjct: 176 WVHKTNVLVNAGSLWQRAIETVGQEYPEVQVDYNHIDAATIYMVTKPQEYDVIVTDNLFG 235 Query: 897 NLVSNVAAGIA---XXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFL 1064 ++++++A + ++ ++FE SA ++ I A+P A L Sbjct: 236 DILTDLAGAVTGGIGLAASGNIDPSRKNPSMFEPVHGSAPDIAGQGI-----ADPCAAIL 290 Query: 1065 SSAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 S A+MLRHL + A+R+E+A V+AE R GG T EV D V+A L Sbjct: 291 SVALMLRHLGDDANAERIEAA---VLAEAGSRD---GGPVKTAEVGDRVVANL 337
>Q9ABN3:LEU3_CAUCR 3-isopropylmalate dehydrogenase - Caulobacter crescentus (Caulobacter| vibrioides) Length = 350 Score = 123 bits (309), Expect = 2e-27 Identities = 118/356 (33%), Positives = 172/356 (48%), Gaps = 28/356 (7%) Frame = +3 Query: 240 TVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE-------TYEVHGDMPSVPTEVIESIRR 398 T+ L+PGDGIGP V VR+V A+ + + +Y+ HG + EV E Sbjct: 3 TLLLLPGDGIGPEVCAQVRRVAAALTPDLKVDEALYGGASYDTHGT--PLTDEVREQALA 60 Query: 399 NKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASL--VNCFN-LPGL----PTRH 539 + L G + P + L LRK +D++A+L CF L G P Sbjct: 61 SDAVLMGAVGGPKWADAPRHLRPEAGLLNLRKAMDVFANLRPAYCFEALAGASSLKPELV 120 Query: 540 ENVDIAVIRENTEGEYSGLEH---EVVPGVVESL--KVMTKFCSERIAKYAFEYAYLNNR 704 +DI +RE G Y G ++ G + +V T ER+ + AFE A Sbjct: 121 SGLDIMFVRELVGGVYFGQPRGIEDLADGQKKGFDTQVYTTSEIERVGRVAFELAR-GRT 179 Query: 705 KKVTAVHKANIMKLADGLFLESCREV-ATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 KV + K+N+M+ + L+ + E+ A +YP +Q I+ DNC MQLV P+QFDV+VT Sbjct: 180 NKVHSAEKSNVME-SGLLWKQVITELHAREYPDVQLEHILADNCAMQLVRAPKQFDVIVT 238 Query: 882 PNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGN-DKILQQKKANPVAL 1058 NL+G+++S+ AA + A + G G+ I + ANP+A Sbjct: 239 DNLFGDILSDAAAMLTGSLGMLPSAALG---APGKPGLYEPIHGSAPDIAGKGLANPLAA 295 Query: 1059 FLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 LS M LR L+ AD L +AVK + G RTRDLGG+ TT ++ DAV+A L Sbjct: 296 ILSFEMALRWSLKQTEAADALLAAVKAALDNGA-RTRDLGGSLTTTQMGDAVLAAL 350
>Q31HI0:LEU3_THICR 3-isopropylmalate dehydrogenase - Thiomicrospira crunogena (strain| XCL-2) Length = 357 Score = 123 bits (308), Expect = 2e-27 Identities = 114/366 (31%), Positives = 180/366 (49%), Gaps = 39/366 (10%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----------HAPVCFETYEVHGDMPSVPTEVIES 389 V ++PGDGIGP +T +V+EA+ H V Y+ HG + E +E Sbjct: 5 VLILPGDGIGPEITAEAVKVLEALQQKDNLDISMTHDLVGGAAYDQHG--VPLAEETLEK 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLNLQLRKE---------LDLYASLVNCFNLPGL----- 527 +++ L G + G SL++ +R E L+L+A+L + P L Sbjct: 63 AKQSDAILLGAVG---GYQWESLDISVRPEKGLLALRSNLELFANLRPAYLFPQLADAST 119 Query: 528 --PTRHENVDIAVIRENTEGEYSGLEHEVVP---GVVESLKVMTKFCSE--RIAKYAFEY 686 P +DI ++RE T G Y G + G + SE RIA AF+ Sbjct: 120 LKPEVVAGLDILIVRELTGGIYFGQPRGIRTLDNGERQGYNTYVYSESEIKRIAHVAFDA 179 Query: 687 AYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQF 866 A N KK+ +V KAN++++ + ++ E EVA +YP ++ + VDN MQLV P+QF Sbjct: 180 AMKRN-KKLCSVDKANVLEVTE-MWREIVDEVAKEYPEVEVQHMYVDNAAMQLVLNPKQF 237 Query: 867 DVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQG-ASAGNVGNDKILQQKK 1040 DVMVT N++G+++S+ A+ + ++ ++E SA ++ I Sbjct: 238 DVMVTGNMFGDILSDEASMLTGSIGMLASASLDANNKGMYEPSHGSAPDIAGQNI----- 292 Query: 1041 ANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS----TTQEVTD 1205 ANP+A LS+AMMLR+ L A ++E+AV V+ +G RT D+ +T E+ D Sbjct: 293 ANPLATILSAAMMLRYSLNREDLALKIETAVSKVLDQG-LRTGDIWSEGLTKVSTSEMGD 351 Query: 1206 AVIAKL 1223 AV+A L Sbjct: 352 AVVAAL 357
>Q3AIH4:LEU3_SYNSC 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain CC9605)| Length = 357 Score = 123 bits (308), Expect = 2e-27 Identities = 111/351 (31%), Positives = 168/351 (47%), Gaps = 30/351 (8%) Frame = +3 Query: 231 APRTVTLIPGDGIGPLVTGAVRQVMEAMHA----PVCFETYEVHGDM-----PSVPTEVI 383 A V L+PGDGIGP +T RQ++E + + FE + G +P + Sbjct: 2 AQHRVVLLPGDGIGPEITAVARQLLEVVSRRHGFSLSFEEQPIGGSAIDATGEPLPASTL 61 Query: 384 ESIRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGLPTRH-- 539 ++ + L + +P + L LR ++L+A+L +P L Sbjct: 62 DACKAADAVLLAAIGSPCFDSLPREKRPETGLLGLRAGMELFANLRPVKIVPALIDASSL 121 Query: 540 -----ENVDIAVIRENTEGEYSGLEHEVVP--GVVESLKVMTKFCSE--RIAKYAFEYAY 692 E VD+ V+RE T G Y G + G MT SE RIAK AFE A Sbjct: 122 KREVIEGVDLMVVRELTGGIYFGQPKGRIETEGDERGFNTMTYSASEVDRIAKVAFEIAQ 181 Query: 693 LNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDV 872 R ++ +V KAN++ ++ L+ + +A Y ++ + + VDN MQLV P QFDV Sbjct: 182 -ERRGRLCSVDKANVLDVSQ-LWRDRVDAMAPSYGPVEVSHMYVDNAAMQLVRDPRQFDV 239 Query: 873 MVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQKKA 1043 ++T NL+G+++S+ AA + + +FE G++ G D KA Sbjct: 240 LLTGNLFGDILSDEAAMLTGSIGMLPSASLGSEGPGLFEPVHGSAPDIAGQD------KA 293 Query: 1044 NPVALFLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQ 1193 NP+A+ LS+AMMLR L+ + AD LE+AV V+A G +RT DL TQ Sbjct: 294 NPMAMVLSAAMMLRIGLKQAAAADDLEAAVDAVLA-GGFRTGDLMAEGCTQ 343
>Q2JL30:LEU3_SYNJB 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain| JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) Length = 371 Score = 123 bits (308), Expect = 2e-27 Identities = 113/364 (31%), Positives = 175/364 (48%), Gaps = 37/364 (10%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE-----------TYEVHGDMPSVPTEVIES 389 +T + GDGIGP + R V++A+ + F Y+ GD +P E ++ Sbjct: 13 ITALAGDGIGPEIMRVGRAVLDAVARQMGFALQWQEGLIGGAAYDQTGD--PLPAETLKM 70 Query: 390 IRRNKVCLKGGL------ATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGL-------P 530 + + + A P L LR L L+A+L P L P Sbjct: 71 AQESDAVYLAAVGDFKYDALPPEKRPERALLGLRAGLGLFANLRPVKVFPQLVGASSLKP 130 Query: 531 TRHENVDIAVIRENTEGEYSGLEHEVVPGVVESLK-VMTKFCSE----RIAKYAFEYAYL 695 +D+ V+RE T G Y G + S + V T SE RIA+ AFE A Sbjct: 131 EVIAGIDLVVVRELTGGIYFGQPKGIFTDAQGSRRGVNTMVYSEAEVDRIARVAFELAR- 189 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 R+K+ +V KAN+++++ L+ E +A +YP ++ + + +DN MQLV P+QFDV+ Sbjct: 190 KRRRKLCSVDKANVLEVSQ-LWRERVNAIAAEYPEVELSHLYIDNAAMQLVRWPKQFDVI 248 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQKKAN 1046 +T NL+G+++S+ AA + ++E G++ G D KAN Sbjct: 249 LTGNLFGDILSDEAAMLTGSIGMLPSASLGSSGPGLYEPVHGSAPDIAGQD------KAN 302 Query: 1047 PVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTT----QEVTDAV 1211 P+A LS A+MLR+ L P ADR+E AV+ V+A+G YRT DL T QE+ + + Sbjct: 303 PIAQVLSGALMLRYSLDQPQAADRIEQAVEAVLAQG-YRTPDLYSEGMTLVGCQEMGEKL 361 Query: 1212 IAKL 1223 +A L Sbjct: 362 VAAL 365
>O33117:LEU3_MYCLE 3-isopropylmalate dehydrogenase - Mycobacterium leprae| Length = 336 Score = 122 bits (307), Expect = 3e-27 Identities = 102/333 (30%), Positives = 158/333 (47%), Gaps = 22/333 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV-----HGDMPSVPTEVIESIRRNKV 407 + +I GDGIGP V ++++ + V TY++ H +P V+ +R + Sbjct: 3 LAIIGGDGIGPEVVAQAVKILDVVLPGVQKTTYDLGARRYHTTGELLPESVLAELREHDA 62 Query: 408 CLKGGLATP-VGGGV--SSLNLQLRKELDLYASLVNCFNLPG---LPTRHENVDIAVIRE 569 L G + P V GV L L+LR ELD + +L PG L ++D V+RE Sbjct: 63 ILLGAVGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVNSLLAGKPDIDFVVVRE 122 Query: 570 NTEGEYSGLEHEVVPG----VVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANI 737 TEG Y+G + G V + V T F R+ + AFE A RK +T VHK N+ Sbjct: 123 GTEGPYTGTGGAIRVGTPNEVATEVSVNTAFGVRRVVQDAFERAR-QRRKHLTLVHKNNV 181 Query: 738 MKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVA 917 + A L+ +EV KYP ++ +D + LV +P +FDV+VT NL+G++++++A Sbjct: 182 LTYAGTLWCRIVQEVGEKYPDVEVVYQHIDAATIYLVTEPSRFDVIVTDNLFGDIITDLA 241 Query: 918 A----GIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAMMLR 1085 A GIA SA ++ I A+P A +S A++L Sbjct: 242 AAVCGGIALAASGNIDATRTNPSMFEPVHGSAPDIAGQGI-----ADPTAAIMSLALLLA 296 Query: 1086 HLQFPSFADRLESAVKGVIA---EGKYRTRDLG 1175 HL A RL+ AV +A G++ T ++G Sbjct: 297 HLGEDEPAARLDQAVASYLATRGNGRFSTGEVG 329
>Q3SHL3:LEU3_THIDA 3-isopropylmalate dehydrogenase - Thiobacillus denitrificans (strain| ATCC 25259) Length = 353 Score = 122 bits (306), Expect = 4e-27 Identities = 109/361 (30%), Positives = 177/361 (49%), Gaps = 34/361 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMH----------APVCFETYEVHGDMPSVPTEVIESI 392 + ++PGDGIGP + +V+EA+ AP+ Y+ GD +P ++ Sbjct: 3 IAVLPGDGIGPEIISQAVKVLEALKSEGAKIEMETAPIGGAGYDAAGD--PLPEATLKLA 60 Query: 393 RRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------PT 533 R L G + P + L++RKEL+L+A+L P L P Sbjct: 61 READAVLLGAVGGPQYDTLDRPLRPERGLLRIRKELNLFANLRPALLYPELASASSLKPE 120 Query: 534 RHENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSE----RIAKYAFEYAYLNN 701 +D+ ++RE T Y G + E + T SE R+A AF A + Sbjct: 121 VVSGLDLMIVRELTGDVYFGQPRGIETRNGERVGFNTMLYSESEVRRVAHVAFGIA-MKR 179 Query: 702 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 KK+ +V KAN+++ ++ L+ E EVA YP ++ + + VDN MQL+ P+QFD +VT Sbjct: 180 GKKLCSVEKANVLECSE-LWKEIMIEVAKDYPEVELSHMYVDNAAMQLIRAPKQFDTIVT 238 Query: 882 PNLYGNLVSNVAAGIAXXXXXXXXXXXXQ-DHAVFEQ-GASAGNVGNDKILQQKKANPVA 1055 N++G+++S+ A+ ++ + + ++E SA ++ + ANP+A Sbjct: 239 GNIFGDILSDAASMLSGSIGMLPSASLDEHNKGMYEPIHGSAPDIAGKNL-----ANPLA 293 Query: 1056 LFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQ----EVTDAVIAK 1220 LS AMM R+ + ADR+E+AVK VIA+G YRT D+ T + E+ DAV+ Sbjct: 294 TILSVAMMYRYTFADLATADRIENAVKQVIAKG-YRTGDIWTEGTQKVSCSEMGDAVVVA 352 Query: 1221 L 1223 L Sbjct: 353 L 353
>Q3AEQ2:LEU3_CARHZ 3-isopropylmalate dehydrogenase - Carboxydothermus hydrogenoformans| (strain Z-2901 / DSM 6008) Length = 374 Score = 122 bits (306), Expect = 4e-27 Identities = 112/369 (30%), Positives = 180/369 (48%), Gaps = 39/369 (10%) Frame = +3 Query: 234 PRTVTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFE-TYEVHGDMP------SVPTEVIE 386 P + ++PGDGIGP + +V++A+ + F Y + G +P E +E Sbjct: 9 PFKILVLPGDGIGPEIIKEAVKVLKALGEKKGITFNFQYGLIGGAAIDERGVPLPEETVE 68 Query: 387 SIRRNKVCLKGGLATPVG-----------GGVSSLNLQLRKELDLYASLVNCFNLPGL-- 527 ++ L G + P GG+ L++RK DLYA+L P L Sbjct: 69 LGKQCDAILLGAVGGPKWDNLPPEIRPELGGL----LKIRKVFDLYANLRPVMFFPELKN 124 Query: 528 -----PTRHENVDIAVIRENTEGEYSGLEHEVVP-----GVVESLKVMTKFCSERIAKYA 677 P E VDI ++RE T G Y G + V+++L + T+ ER+ + Sbjct: 125 ASPLKPDIIEGVDILMVRELTGGLYFGEKKRFTTEQGEQAVIDTL-IYTEKEVERVVRLG 183 Query: 678 FEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKP 857 FE A R K+T V KAN+++ + + E E+ +YP ++ + + VDNC MQL+ P Sbjct: 184 FELAQ-KRRGKLTLVDKANVLE-SSRFWREITGEIKKEYPDVELSYMYVDNCAMQLIRNP 241 Query: 858 EQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQ 1031 QFDV+VT N++G+++++ + +A ++E G++ G Sbjct: 242 RQFDVIVTENMFGDILTDEGSVLAGSIGLLPSASLNGKFGLYEPIHGSAPDIAG------ 295 Query: 1032 QKKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTS--TTQE 1196 Q KANP+A LS+ MMLR+ L P A +E AVK V+ +G YRT D+ GT+ T +E Sbjct: 296 QNKANPLATILSAGMMLRYSLDCPEEALLIEKAVKAVLQKG-YRTGDILEPGTTLVTCEE 354 Query: 1197 VTDAVIAKL 1223 + D V ++ Sbjct: 355 MGDLVAEEI 363
>P56063:IDH_HELPY Isocitrate dehydrogenase [NADP] - Helicobacter pylori (Campylobacter| pylori) Length = 425 Score = 122 bits (306), Expect = 4e-27 Identities = 101/372 (27%), Positives = 164/372 (44%), Gaps = 68/372 (18%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVM-----------------EAMHAPVCFETYEVHGDMPS-- 365 + I GDGIG +T A+ +V+ E C++ ++ + ++ Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDYKELSPEE 91 Query: 366 --VPTEVIESIRRNKVCLKGGLATPVGGGVSSLNLQLRKELDLYASL--VNCFNLPGLPT 533 + + IE+I KV +KG L TP+G G SLN+ LR+++DLY L V + P Sbjct: 92 QWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVK 151 Query: 534 RHENVDIAVIRENTEGEYSGLEHEVVPGVVESL-----------------------KVMT 644 + VD+ + REN+E Y+G+E + + L K ++ Sbjct: 152 EPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESSGIGVKPIS 211 Query: 645 KFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFL---------ESCREVATKYP 797 K +ER+ + A EYA N++ VT VHK NIMK +G F+ E +V K P Sbjct: 212 KEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFNAQVIDKGP 271 Query: 798 -----------GIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVAAGIAXXXXX 944 I ++I D Q++ +P ++ V+ T NL G+ +S+ A + Sbjct: 272 WCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAAMVGGIGI 331 Query: 945 XXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVALFLSSAMMLRHLQFPSFADRL 1118 +FE G + G DK+ NP ++ LS+ MMLRH+ + AD + Sbjct: 332 APGANLNDTVGMFEATHGTAPKYAGLDKV------NPGSIILSAEMMLRHMGWVEAADLI 385 Query: 1119 ESAVKGVIAEGK 1154 SA++ I K Sbjct: 386 VSAMEKAIKSKK 397
>P24098:LEU3_THEAQ 3-isopropylmalate dehydrogenase - Thermus aquaticus| Length = 344 Score = 122 bits (305), Expect = 5e-27 Identities = 111/351 (31%), Positives = 170/351 (48%), Gaps = 24/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP----VCFETYEVHG--------DMPSVPTEVIE 386 V ++PGDGIGP VT A +V++A+ + +ET+ G P V + +E Sbjct: 3 VAVLPGDGIGPEVTEAALRVLKALDEREGLGLTYETFPFGGAAIDGYGEPFPEVTRKGVE 62 Query: 387 SIRRNKVCLKGGL---ATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGL----PTRHE- 542 + + GG A P S L LRK DL+A+L PGL P + E Sbjct: 63 AAEAVLLGSVGGPKWDALPRKIRPESGLLALRKSQDLFANLRPAKVFPGLERLSPLKEEI 122 Query: 543 --NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVT 716 VD+ ++RE T G Y G + + + +K ER+AK AFE A R+ +T Sbjct: 123 ARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVAKVAFEAAR-KRRRHLT 181 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 +V KAN++++ + + ++ EV YP + + VD M LV P +FDV+VT N++G Sbjct: 182 SVDKANVLEVGE-FWRKTVEEVHKGYPDVALDHQYVDAMAMHLVKNPARFDVVVTGNIFG 240 Query: 897 NLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSA 1073 +++S++A+ + + VFE SA ++ I ANP A LS+A Sbjct: 241 DILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGI-----ANPTAAILSAA 295 Query: 1074 MMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 MML H A R+E+AV + E DLGG++ TQ T+ V+ L Sbjct: 296 MMLEHAFGLVELARRVEAAVAKALRETP--PPDLGGSAGTQAFTEEVLRHL 344
>Q8DPJ4:LEU3_STRR6 3-isopropylmalate dehydrogenase - Streptococcus pneumoniae (strain| ATCC BAA-255 / R6) Length = 345 Score = 122 bits (305), Expect = 5e-27 Identities = 108/354 (30%), Positives = 182/354 (51%), Gaps = 25/354 (7%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH------GDM----PSVPTEVIE 386 + + + GDGIGP + A +V+EA+ F+ YE+ D+ P +P E ++ Sbjct: 3 KKIVALVGDGIGPEIMEAGLEVLEALAEKTGFD-YEIDRRPFGGADIDAAGPPLPDETLK 61 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLNLQ----LRKELDLYASL--VNCFNL-----PGLPT 533 + R L + +P GV+ Q LRKEL+LYA++ V F+ P P Sbjct: 62 ASREADAILLVAIGSPQYDGVAVRPEQGLMALRKELNLYANIRPVKIFDSLKYLSPLKPE 121 Query: 534 RHENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKV 713 R VD V+RE T Y G +H + + + ERI + AFE A N RK V Sbjct: 122 RISGVDFVVVRELTGEIYFG-DHILEERKARDINDYSYEEVERIIRKAFEIAR-NRRKIV 179 Query: 714 TAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 893 T++ K N++ + L+ + EVA +P + +VD+ M ++ P +FDV+VT NL+ Sbjct: 180 TSIDKQNVLATSK-LWRKVAEEVAQDFPDVTLEHQLVDSAAMLMITNPAKFDVIVTENLF 238 Query: 894 GNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQ-GASAGNVGNDKILQQKKANPVALFLS 1067 G+++S+ ++ ++ ++ +++E SA ++ I ANP+++ LS Sbjct: 239 GDILSDESSVLSGTLGVMPSASHSENGPSLYEPIHGSAPDIAGQGI-----ANPISMILS 293 Query: 1068 SAMMLRHLQFPSFAD--RLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 MMLR F + D R++ AV+ +A G TRD+GG ++T+E+ +A+IA+L Sbjct: 294 VVMMLRD-SFGRYEDTERIKRAVETSLAAG-ILTRDIGGQASTKEMMEAIIARL 345
>Q28W67:LEU3_JANSC 3-isopropylmalate dehydrogenase - Jannaschia sp. (strain CCS1)| Length = 366 Score = 122 bits (305), Expect = 5e-27 Identities = 119/370 (32%), Positives = 183/370 (49%), Gaps = 41/370 (11%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFET---------YEVHGDMPSVPTEVI 383 R++ ++PGDGIGP V VR++++ + + F+ Y+ HG + + Sbjct: 4 RSLLILPGDGIGPEVMAEVRKIIDWFGSARGISFDVSEDLVGGAAYDAHG--VPLTDATM 61 Query: 384 ESIRRNKVCLKGGLATPVGGGVS-SLN-----LQLRKELDLYASL--VNCFN-LPGLPTR 536 E + L G + P + S+ L+LRKE+DLYA+L CF+ L + Sbjct: 62 EKAQSVDAVLLGAVGGPAYDDLDFSVKPERGLLRLRKEMDLYANLRPAQCFDALADFSSL 121 Query: 537 HENV----DIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSE----RIAKYAFEYAY 692 + DI ++RE T G Y G + E + + T+ +E R A AFE A Sbjct: 122 KREIVSGLDIMILRELTSGVYFGEPRGIHTEGNERVGINTQRYTETEIARAAHSAFELAR 181 Query: 693 LNNRKKVTAVHKANIMKLADGLFLESCREV-ATKYPGIQYNEIIVDNCCMQLVAKPEQFD 869 N K V ++ KAN+M+ + L+ + EV A Y +Q + + DN MQLV P+QFD Sbjct: 182 RRNNK-VCSMEKANVME-SGILWRDVVNEVHAADYGDVQLSHMYADNGAMQLVRAPKQFD 239 Query: 870 VMVTPNLYGNLVSNVAA------GIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQ 1031 V++T NL+G+++S+ AA G+ + A++E + I Sbjct: 240 VILTDNLFGDILSDCAAMLTGSLGMLPSASLGAPMANGRPKAMYEPVHGSA----PDITG 295 Query: 1032 QKKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL----GGTS-TTQ 1193 Q KANP+A LS AM LR+ A RLE AV+ V+A+G RT DL GGT +T Sbjct: 296 QGKANPIACILSFAMALRYSFDLGDEATRLEGAVESVLADGA-RTADLMGPDGGTPISTS 354 Query: 1194 EVTDAVIAKL 1223 ++ DA++AKL Sbjct: 355 QMGDAIVAKL 364
>Q3B595:LEU3_PELLD 3-isopropylmalate dehydrogenase - Pelodictyon luteolum (strain DSM| 273) (Chlorobium luteolum (strain DSM 273)) Length = 353 Score = 121 bits (304), Expect = 7e-27 Identities = 104/359 (28%), Positives = 172/359 (47%), Gaps = 32/359 (8%) Frame = +3 Query: 243 VTLIPGDGIGP-LVTGA---VRQV-------MEAMHAPVCFETYEVHGDMPSVPTEVIES 389 + IPGDGIGP +V GA +RQ+ ++ P +Y++HG M + E + + Sbjct: 4 IVSIPGDGIGPEVVAGALAVIRQITKKHGFEIQVEEHPFGGASYDLHGSM--LTDETLNA 61 Query: 390 IRRNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASL---------VNCFNLPG 524 R L G + P + + L++R+EL L+A+L V+ +L Sbjct: 62 CRDCDAVLLGAVGGPKWENLPHEHKPEAALLKIRRELGLFANLRPAKVYDALVDASSLKA 121 Query: 525 LPTRHENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNR 704 R D V RE T G Y G + V K ERIA+ AFE A Sbjct: 122 DVVR--GTDFMVFRELTGGIYFGEPRGFDEKRGWNTMVYEKHEVERIARLAFEAAQKRGS 179 Query: 705 KKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTP 884 K+V ++ KAN+++++ + V +P ++ +++ VDN MQ+V P+QFDV+VT Sbjct: 180 KRVMSIDKANVLEVSQ-FWRNEVHRVHRDFPDVELSDMYVDNAAMQIVRNPKQFDVIVTG 238 Query: 885 NLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALF 1061 NL+G+++S++A I + HA++E SA ++ I ANP+A Sbjct: 239 NLFGDILSDIAGMITGSLGMLPSASIGRVHALYEPIHGSAPDIAGKNI-----ANPIATI 293 Query: 1062 LSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGG----TSTTQEVTDAVIAKL 1223 S AMM H ++ + +A++G ++EG RT D+ + +T E+T+ +I L Sbjct: 294 ASVAMMFEHSFCMADISNEIHAAIEGALSEG-LRTADIAAPGQKSVSTTEMTEGIIRHL 351
>P76251:TTUC_ECOLI Probable tartrate dehydrogenase/decarboxylase - Escherichia coli| Length = 361 Score = 121 bits (303), Expect = 9e-27 Identities = 112/362 (30%), Positives = 174/362 (48%), Gaps = 39/362 (10%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEA-------------MHAPVCFETYEVHGDMPSVPTEVI 383 + IPGDGIG V +V++A M C E Y HG M +P + Sbjct: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASC-EYYSHHGKM--MPDDWH 63 Query: 384 ESIRRNKVCLKGGLATP--VGGGVSSLN--LQLRKELDLYASLVNCFNLPGLPT-----R 536 E + R G + P V +S L+ R+E D Y +L PG+P + Sbjct: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 Query: 537 HENVDIAVIRENTEGEYS--------GLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAY 692 ++D V+RENTEGEYS G EHEVV + ES V T+ +RI +YAFE A Sbjct: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVV--IQES--VFTRRGVDRILRYAFELAQ 179 Query: 693 LNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDV 872 RK +T+ K+N + ++ + E +A YP I++++ +D C + V +PE+FDV Sbjct: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 Query: 873 MVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH---AVFEQ-GASAGNVGNDKILQQKK 1040 +V NL+G+++S++ + ++FE SA ++ I Sbjct: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI----- 294 Query: 1041 ANPVALFLSSAMMLRHL-----QFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTD 1205 ANP+A + AMML L +F + + +A++ VIA G +T D+ G +TT +V D Sbjct: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVAD 353 Query: 1206 AV 1211 A+ Sbjct: 354 AI 355
>Q1IZK2:LEU3_DEIGD 3-isopropylmalate dehydrogenase - Deinococcus geothermalis (strain| DSM 11300) Length = 351 Score = 121 bits (303), Expect = 9e-27 Identities = 111/361 (30%), Positives = 173/361 (47%), Gaps = 26/361 (7%) Frame = +3 Query: 234 PRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE-------TYEVHGDMPSVPTEVIESI 392 P+ VTL PGDGIGP VT A +V+ + V E YE GD P +++ Sbjct: 2 PKVVTL-PGDGIGPEVTAAAAEVLREVAPDVHIEEHAIGGAAYEQFGD--PFPQRTRDAL 58 Query: 393 RRNKVCLKGGLATPVGGGVSSLN---------LQLRKELDLYASLVNCFNLPGL------ 527 L G + +SL L LR+ L YA+L LPGL Sbjct: 59 GDADAVLLGTVGGAQNSPWNSLPRPLRPESGLLALRRALGCYANLRPVRVLPGLEHLSPL 118 Query: 528 -PTRHENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNR 704 P VDI ++RE G Y + ++ + T ER+A+ AF +A R Sbjct: 119 KPELARGVDILIVRELLGGIYFDGDRKIEGDTAYNTMRYTTPEVERVARVAF-WAAEQRR 177 Query: 705 KKVTAVHKANIMKLADGLFLESCREVATK-YPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 +VT+V KAN++++++ L+ + + + Y + N VD+ M +VA P ++DV++T Sbjct: 178 GRVTSVDKANVLEVSE-LWRRDVQALRDREYRNVHLNHEYVDSVAMLIVANPSRYDVILT 236 Query: 882 PNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVAL 1058 NL+G+++S++AA I +FE SA ++ I ANP A Sbjct: 237 ENLFGDILSDLAAVIPGSLGLMPSASLGDGPGLFEPIHGSAPDIAGQGI-----ANPAAA 291 Query: 1059 FLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD*PP 1235 +S AM+LRH L+ P A+++E AV +A ++ TRDLGG + T+ T AV+ + P Sbjct: 292 IMSVAMLLRHGLERPQVANQVERAV--ALALREHPTRDLGGQADTRTFTHAVLDAMGSPS 349 Query: 1236 I 1238 + Sbjct: 350 V 350
>Q7NUC2:LEU3_CHRVO 3-isopropylmalate dehydrogenase - Chromobacterium violaceum| Length = 354 Score = 121 bits (303), Expect = 9e-27 Identities = 107/340 (31%), Positives = 164/340 (48%), Gaps = 30/340 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM----------HAPVCFETYEVHGDMPSVPTEVIESI 392 + ++PGDGIGP + +V+E + HAP+ Y+ +G P + Sbjct: 3 IAILPGDGIGPEIIAQAERVLEVLRRDGLKIETEHAPLGGAAYDQYG--VPYPEATQKLA 60 Query: 393 RRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------PT 533 R L G + P + L +RK+L+L+A+L P L P Sbjct: 61 READAVLLGAVGGPAYDKLDRPLRPERGLLAIRKDLNLFANLRPAILYPELANASTLKPE 120 Query: 534 RHENVDIAVIRENTEGEYSGLEHEVVP---GVVESLKVMTKFCSE--RIAKYAFEYAYLN 698 +DI ++RE T Y G + G E+ M SE RIA AF A Sbjct: 121 VVAGLDIMIVRELTGDIYFGQPRGIAVNELGEREAYNTMRYSESEVRRIAHVAFGIAMKR 180 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 NRK + +V KAN+++ + + E EVA +YP ++ + + VDN MQLV P+QFDVMV Sbjct: 181 NRK-LCSVDKANVLETTE-FWKEIMIEVAKEYPQVELSHMYVDNAAMQLVRNPKQFDVMV 238 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQGASAGNVGNDKILQQKKANPVA 1055 T N++G+++S+ A+ + Q++ ++E + I Q ANP+A Sbjct: 239 TGNIFGDILSDEASMLTGSIGMLPSASLDQNNKGLYEPSHGSA----PDIAGQNLANPLA 294 Query: 1056 LFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL 1172 LS+AMMLR+ + A R+E AVK V+A+G YRT D+ Sbjct: 295 TILSAAMMLRYSFGQEAAARRVEDAVKKVLAQG-YRTADI 333
>Q1QUR0:LEU3_CHRSD 3-isopropylmalate dehydrogenase - Chromohalobacter salexigens (strain| DSM 3043 / ATCC BAA-138 / NCIMB 13768) Length = 359 Score = 121 bits (303), Expect = 9e-27 Identities = 113/362 (31%), Positives = 174/362 (48%), Gaps = 35/362 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYE----------VHGDMPSVPTEVIE 386 R + ++PGDGIGP +T +++ A + E HG +P E + Sbjct: 3 RKILVLPGDGIGPEITREAVKILNACREAGLEASIEEGLVGGAGIDAHG--VPLPDETLA 60 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL------ 527 S + L G + P + L+ L LRK L+L+ +L P L Sbjct: 61 SAKAADAVLLGAVGGPQWDKIEDLSKRPEKGLLGLRKNLNLFGNLRPALLYPQLASASSL 120 Query: 528 -PTRHENVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAY 692 P +DI ++RE T G Y G+E V + + + ERI + AFE A Sbjct: 121 KPEIVAGLDIMIVRELTGGIYFGQPRGIEERDGERVGYNTYIYAEHEIERIGRVAFEMAR 180 Query: 693 LNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDV 872 K+ +V KAN+++ A L+ E +A +YP + + + VDN MQLV P+QFDV Sbjct: 181 -ERGGKLCSVDKANVLE-ATILWREVMERLAPEYPDVALSHMYVDNAAMQLVRAPKQFDV 238 Query: 873 MVTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKAN 1046 +VT N++G+++S+ AA + Q ++E SA ++ I AN Sbjct: 239 IVTGNMFGDILSDAAAMLTGSIGMLPSASLNEQRQGMYEPCHGSAPDIAGQGI-----AN 293 Query: 1047 PVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLG--GTS--TTQEVTDAV 1211 P+A LS AMMLR+ L+ P A+R+E AV V+ +G RT D+ GT+ +TQ + DAV Sbjct: 294 PLATILSVAMMLRYSLEAPQLAERIERAVGTVLDQG-LRTADIAFEGTAPVSTQAMGDAV 352 Query: 1212 IA 1217 +A Sbjct: 353 LA 354
>Q3AYS1:LEU3_SYNS9 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain CC9902)| Length = 357 Score = 120 bits (302), Expect = 1e-26 Identities = 111/340 (32%), Positives = 163/340 (47%), Gaps = 30/340 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHA----PVCFETYEVHGDM-----PSVPTEVIESIR 395 V L+PGDGIGP +T RQ+++ + + FE + G +P + + R Sbjct: 6 VVLLPGDGIGPEITAVARQLLDVVAQRHGFQLMFEEQPIGGSAIDATGEPLPASTLTACR 65 Query: 396 RNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGLPTRH------ 539 L + +P + L LR L+L+A+L +P L Sbjct: 66 SADAVLLAAIGSPRFDSLPREKRPETGLLGLRSGLELFANLRPVKIVPALIGASSLKQEV 125 Query: 540 -ENVDIAVIRENTEGEYSGLEHEVVP--GVVESLKVMTKFCSE--RIAKYAFEYAYLNNR 704 E VD+ V+RE T G Y G + G MT SE RIAK AFE A N Sbjct: 126 IEGVDLMVVRELTGGIYFGQPKGRIEADGDERGFNTMTYSASEVDRIAKVAFEIAGERNN 185 Query: 705 KKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTP 884 + + +V KAN++ ++ L+ + +A +Y + + + VDN MQLV P QFDV++T Sbjct: 186 R-LCSVDKANVLDVSQ-LWRDRVDAMAPRYGEVDVSHMYVDNAAMQLVRDPRQFDVLLTG 243 Query: 885 NLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQKKANPVA 1055 NL+G+++S+ AA + D +FE G++ G D KANP+A Sbjct: 244 NLFGDILSDEAAMLTGSIGMLPSASLGSDGPGLFEPVHGSAPDIAGQD------KANPMA 297 Query: 1056 LFLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDL 1172 + LS+AMMLR L+ S AD LE AV V+A G +RT DL Sbjct: 298 MVLSAAMMLRIGLKQSSAADDLERAVDAVLASG-FRTGDL 336
>Q2RGA0:LEU3_MOOTA 3-isopropylmalate dehydrogenase - Moorella thermoacetica (strain ATCC| 39073) Length = 357 Score = 120 bits (302), Expect = 1e-26 Identities = 105/337 (31%), Positives = 166/337 (49%), Gaps = 27/337 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE---TYEVHGDMP------SVPTEVIESIR 395 + ++PGDGIGP + +V+EA+ V E T + G ++P E +E R Sbjct: 4 IAVLPGDGIGPEIVPEAVKVLEAVSRRVGIEFQFTEALVGGAAIDARGIALPPETLELCR 63 Query: 396 RNKVCLKGGLATPVGGGV-------SSLNLQLRKELDLYASLVNCFNLPGL----PTRHE 542 ++ L G + P + ++ L LRKEL LYA+L F L P + E Sbjct: 64 QSDAVLLGAVGGPKWDTLPPAERPETAALLPLRKELGLYANLRPAFLYDSLVEASPLKKE 123 Query: 543 NV---DIAVIRENTEGEYSGL---EHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNR 704 V D+ ++RE T G Y G E + T+ ERI + AF A R Sbjct: 124 IVTGTDLIIVRELTGGLYFGAKKREQTAEGEMAYDTMYYTRAEIERIVRLAFTIAR-QRR 182 Query: 705 KKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTP 884 +T+V KAN++ + L+ ++ ++ ++P + + VDNC MQLV +P QFDV+VT Sbjct: 183 CHLTSVDKANVLTTSR-LWRDTVEDIKGEFPEVTVEHMYVDNCAMQLVRRPAQFDVIVTE 241 Query: 885 NLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFL 1064 N +G+++S+ A+ + A++E + I Q+KANP+A L Sbjct: 242 NTFGDILSDQASVLTGSIGMLPSASIGGAVALYEPCHGSA----PDIAGQQKANPLATIL 297 Query: 1065 SSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL 1172 S+AMML++ + A +E+AV V+A+G YRT DL Sbjct: 298 SAAMMLKYSFKMDQAAAAIEAAVGRVLAKG-YRTPDL 333
>Q8G500:LEU3_BIFLO 3-isopropylmalate dehydrogenase - Bifidobacterium longum| Length = 343 Score = 120 bits (302), Expect = 1e-26 Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 24/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVC---FETYEVHG-----DMPSVPTEVIESIRR 398 + +IPGDGIG VT ++ +E V +E +++ D +P + E I+ Sbjct: 7 IAVIPGDGIGKEVTPWAQKALEKAAEGVADFEYENFDLGAERYLRDGAILPEDEEERIKA 66 Query: 399 NKVCLKGGLATP-VGGGV--SSLNLQLRKELDLYASLVNCFNLPGLPTRHEN---VDIAV 560 N L G + P + G+ L L+LR +LD Y +L G+ + N +D V Sbjct: 67 NDAILLGAVGDPRIKAGILERGLLLKLRFDLDQYVNLRPSKLYKGVTSPLANPGDIDFVV 126 Query: 561 IRENTEGEYSG----LEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHK 728 +RE TEG Y G + V + + T + ER+ +YAF+ A + +K VT VHK Sbjct: 127 VREGTEGLYCGAGGAVRRNTPQEVATEVSINTAYGVERVVRYAFKLA-MKRKKHVTLVHK 185 Query: 729 ANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVS 908 N++ A ++ +V +YP + ++ +D + LV+ P +FDV++T NL+G++++ Sbjct: 186 KNVLVNAGDMWQRIVDKVGEEYPEVTHDYQHIDAATIFLVSDPSRFDVILTDNLFGDILT 245 Query: 909 NVAAGIAXXXXXXXXXXXXQDH---AVFE--QGASAGNVGNDKILQQKKANPVALFLSSA 1073 + A + ++FE G++ G Q KANP A LS+A Sbjct: 246 DEAGSVVGGVGYSASGCINASDEFPSMFEPIHGSAPDIAG------QNKANPTAAILSAA 299 Query: 1074 MMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGT-STTQEVTDAVIAKL 1223 M+L HL F A ++ +AV+ I E LG T +T +V ++A++ Sbjct: 300 MLLEHLGFDDAAKKIHTAVEADIEE-------LGSTVRSTDQVGKDILARM 343
>Q4FP17:LEU3_PELUB 3-isopropylmalate dehydrogenase - Pelagibacter ubique| Length = 368 Score = 120 bits (301), Expect = 1e-26 Identities = 112/371 (30%), Positives = 182/371 (49%), Gaps = 42/371 (11%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE-----------TYEVHGDMPSVPTEVI 383 R + L+PGDGIGP V V++V+ +++ + +Y+ HG + EV Sbjct: 7 RKILLLPGDGIGPEVIQEVKKVILWLNSNKSLDFEIDEDLAGGCSYDKHGT--PITDEVF 64 Query: 384 ESIRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL------ 527 ++ + G + P + L+LRKEL L+A+L L Sbjct: 65 YKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLVDASTL 124 Query: 528 -PTRHENVDIAVIRENTEGEYSGLEHEVVP---GVVESLKVMTKFCSE--RIAKYAFEYA 689 P +DI ++RE T G Y G + P G + + + SE R+AK AF+ A Sbjct: 125 KPEIVSGLDIMIVRELTGGIYFGEPRGIKPIENGERKGINTHSYTTSEIVRVAKVAFDLA 184 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVATK-YPGIQYNEIIVDNCCMQLVAKPEQF 866 + + VT+ K+N+M+ A L+ E +E+ K Y ++ + ++ DNC MQL+ P+QF Sbjct: 185 RKRSNR-VTSCEKSNVME-AGQLWKEEVQELHDKEYKDVELSHMLADNCAMQLLKNPKQF 242 Query: 867 DVMVTPNLYGNLVSNVAA------GIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKI 1025 DV+VT NL+G+++S+ A+ G+ + A++E SA ++ +I Sbjct: 243 DVIVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEI 302 Query: 1026 LQQKKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS----TT 1190 ANP+A LS AM LR+ L S AD LE AV+ V+ +G RT+D+ +T Sbjct: 303 -----ANPIASILSFAMALRYSLDLDSEADALEKAVQDVLNDG-LRTKDILSQGKKEVST 356 Query: 1191 QEVTDAVIAKL 1223 + DA+I+KL Sbjct: 357 SAMGDAIISKL 367
>Q65V05:LEU3_MANSM 3-isopropylmalate dehydrogenase - Mannheimia succiniciproducens| (strain MBEL55E) Length = 358 Score = 120 bits (301), Expect = 1e-26 Identities = 108/346 (31%), Positives = 168/346 (48%), Gaps = 31/346 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFET----YEVHGDM-----PSVPTEVIESIR 395 V ++PGDGIGP V +V++ + A F+ Y V G +P E ++ Sbjct: 6 VAVLPGDGIGPEVMAEAIKVLDKVQAKFGFKLNFTQYLVGGAAIDAKGEPLPAETLQGCD 65 Query: 396 RNKVCLKGGLATPVGGGVS-------SLNLQLRKELDLYASLVNCFNLPGL----PTRHE 542 L G + P + L LRK L+ +L GL P R + Sbjct: 66 NADAILFGSVGGPKWTHLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFCPLRAD 125 Query: 543 ----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 D+ V+RE T G Y G + E +V K+ ERIA+ AF+ A + Sbjct: 126 IAAKGFDMVVVRELTGGIYFGQPKGRDGEGSDTRAFDTEVYYKYEIERIARAAFDAA-MK 184 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 RK+VT+V KAN+++ + L+ E+ E+A +YP +Q + +DN MQL+ PE FDV++ Sbjct: 185 RRKQVTSVDKANVLQ-SSILWRETVAEIAKEYPEVQVENMYIDNATMQLIKAPESFDVLL 243 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE-QGASAGNVGNDKILQQKKANPV 1052 N++G+++S+ AA I ++ ++E G SA ++ I ANP+ Sbjct: 244 CSNIFGDIISDEAAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKGI-----ANPI 298 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST 1187 A LS+AMMLR+ A +E+AV+ V+A+G +RT DL ST Sbjct: 299 AQILSAAMMLRYSFNLNEAATAIENAVQKVLADG-HRTGDLADNST 343
>Q9RTH9:LEU3_DEIRA 3-isopropylmalate dehydrogenase - Deinococcus radiodurans| Length = 352 Score = 120 bits (301), Expect = 1e-26 Identities = 114/365 (31%), Positives = 174/365 (47%), Gaps = 31/365 (8%) Frame = +3 Query: 234 PRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE-------TYEVHGDMPSVPTEVIESI 392 P+ +TL PGDGIGP VT A QV+ + V E Y+ HG+ PT +++ Sbjct: 2 PKVITL-PGDGIGPEVTAAAVQVLREVAPDVTVEEHAIGGGAYDAHGE--PFPTSTRDAL 58 Query: 393 RRNKVCLKGGLATPVGGGVSSL-------------NLQLRKELDLYASLVNCFNLPGL-- 527 + L G VGG S L LRK L YA+L PGL Sbjct: 59 KEADAVLLG----TVGGAHDSAWNQLPRHLRPESGLLALRKALGCYANLRPVRVQPGLEH 114 Query: 528 --PTRHE---NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAY 692 P + E VDI ++RE G Y + ++ + T ER+AK AF +A Sbjct: 115 LSPLKAELARGVDILIVRELLGGIYFDQDRKIEGDTAYNTMRYTTSEVERVAKVAF-WAA 173 Query: 693 LNNRKKVTAVHKANIMKLADGLFLESCREVATK-YPGIQYNEIIVDNCCMQLVAKPEQFD 869 + +VT+V KAN++++++ L+ + + + Y I N VD+ M +VA P ++D Sbjct: 174 EQRKGRVTSVDKANVLEVSE-LWRRDVQALRDRDYRSIHLNHEYVDSVAMLIVADPSRYD 232 Query: 870 VMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKA 1043 V++T NL+G+++S++AA I +FE G++ G Q A Sbjct: 233 VILTENLFGDILSDLAAVIPGSLGLMPSASLGDGAGLFEPIHGSAPDIAG------QGVA 286 Query: 1044 NPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAK 1220 NP A +S M+LRH L+ A++++ AV +A + TRDLGG++ TQ T AV+ Sbjct: 287 NPAAAIMSVGMLLRHGLERSEAANQVDRAV--ALALREQPTRDLGGSADTQTFTRAVLKA 344 Query: 1221 LD*PP 1235 L P Sbjct: 345 LGSSP 349
>Q8FPV5:LEU3_COREF 3-isopropylmalate dehydrogenase - Corynebacterium efficiens| Length = 340 Score = 120 bits (301), Expect = 1e-26 Identities = 106/348 (30%), Positives = 171/348 (49%), Gaps = 23/348 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV---------HGDMPSVPTEVIESIR 395 + +I GDGIGP VT +V+ A+ A + ET ++ +G++ + E + +R Sbjct: 3 LAVIGGDGIGPEVTDEALKVLRALRADI--ETTDLDLGARRYLRNGEL--LTDEDLALLR 58 Query: 396 RNKVCLKGGLATP--VGGGV--SSLNLQLRKELDLYASLVNCFNLPGLPTRHEN---VDI 554 + L G + P V GV L L+LR LD + +L G+ + +N +D Sbjct: 59 EHDAILLGAIGAPGSVPPGVLERGLLLKLRFALDHHVNLRPSKLYEGVESPLKNPGEIDF 118 Query: 555 AVIRENTEGEYSGLEHEVVPGV----VESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 V+RE TEG Y+G + G V T++ +ER+ +YAFE A + R+ +T V Sbjct: 119 VVVREGTEGAYTGNGGAIRVGTPHETANETSVNTRYGAERVIRYAFELAQ-SRRRHLTLV 177 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 HK N++ GL+ + EVA +YP + + +D + LV P +FDV+VT NL+G++ Sbjct: 178 HKTNVLVHGGGLWQRTVDEVAREYPEVTVDYNHIDAATIYLVTDPSRFDVIVTDNLFGDI 237 Query: 903 VSNVAAGIA---XXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSA 1073 +++ A I+ + ++FE + I+ + A+P A LS+A Sbjct: 238 LTDEAGAISGGIGLAASGNIDATGTNPSMFEPVHGSA----PDIMGKGIADPTAAILSAA 293 Query: 1074 MMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIA 1217 MMLRHL + A R+E AV +A RD +T EV D + A Sbjct: 294 MMLRHLGDEANAVRIEEAVARDVA-----GRDPEAPISTTEVGDRIAA 336
>Q6NHM7:LEU3_CORDI 3-isopropylmalate dehydrogenase - Corynebacterium diphtheriae| Length = 339 Score = 120 bits (301), Expect = 1e-26 Identities = 104/353 (29%), Positives = 172/353 (48%), Gaps = 26/353 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV-------HGDMPSVPTEVIESIRRN 401 + +I GDGIGP VT +V+ A+ + Y++ +G++ + + S+R + Sbjct: 3 LAVIGGDGIGPEVTAEALKVLNAVRDDIEVTDYDLGARRYLRNGEL--LADADLVSLREH 60 Query: 402 KVCLKGGLATP--VGGGV--SSLNLQLRKELDLYASLVNCFNLPGLPTRHEN---VDIAV 560 L G + P V GV L L++R LD + +L P + N +D V Sbjct: 61 DAILLGAIGAPGEVPPGVLERGLLLKMRFALDHHVNLRPSKLYPTATSPLANPGDIDFVV 120 Query: 561 IRENTEGEY--------SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVT 716 +RE TEG Y G HE+ V ++ T++ ER+ + AFE A N +K +T Sbjct: 121 VREGTEGLYCGNGGTLREGTPHEIASEVSQN----TRYGVERVVRDAFERAQ-NRKKHLT 175 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 VHK N++ A GL+ + E+AT+YP + + +D + +V P ++DV+VT NL+G Sbjct: 176 LVHKTNVLVNAGGLWQRTVNEIATEYPEVTVDYNHIDAATIYMVTDPSRYDVIVTDNLFG 235 Query: 897 NLVSNVAAGIAXXXXXXXXXXXXQ---DHAVFEQ-GASAGNVGNDKILQQKKANPVALFL 1064 ++++++A + + ++FE SA ++ I A+P A L Sbjct: 236 DILTDLAGAVTGGIGLAASGNIDATGVNPSMFEPVHGSAPDIAGQGI-----ADPTAAIL 290 Query: 1065 SSAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 S+AM+LRH+ S A R+E+AV +AE G T EV D ++A L Sbjct: 291 SAAMLLRHVGDESNAQRIEAAVTYDVAERP------AGPVKTVEVGDRIVAAL 337
>Q51945:TTUC_PSEPU Tartrate dehydrogenase/decarboxylase - Pseudomonas putida| Length = 365 Score = 120 bits (300), Expect = 2e-26 Identities = 114/370 (30%), Positives = 183/370 (49%), Gaps = 42/370 (11%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP----VCFETYE--------VHGDMPSVPTEVIE 386 + IPGDGIG V +V+EA + F+T+E HG M +P + E Sbjct: 8 IAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKM--MPDDWAE 65 Query: 387 SIRRNKVCLKGGLATP--VGGGVSSLN--LQLRKELDLYASLVNCFNLPGLPTRHEN--- 545 +++ G + P V +S L+ R+E D Y ++ PG+P N Sbjct: 66 QLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCALANRKV 125 Query: 546 --VDIAVIRENTEGEYSGL--------EHEVVPGVVESLKVMTKFCSERIAKYAFEYAYL 695 +D V+RENTEGEYS L E+E+V + ES + T+ +RI KYAF+ A Sbjct: 126 GDIDFVVVRENTEGEYSSLGGIMFENTENEIV--IQES--IFTRRGVDRILKYAFDLAEK 181 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD-V 872 RK VT+ K+N M ++ + + +A YP + +++ +D C + V +PE+FD V Sbjct: 182 RERKHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERFDVV 241 Query: 873 MVTPNLYGNLVSNV---AAGIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKK 1040 +V NL+G+++S++ AG ++FE SA ++ I Sbjct: 242 VVASNLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNI----- 296 Query: 1041 ANPVALFLSSAMMLRHL-----QFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTD 1205 ANP+A+ S A+ML L ++ D + +A++ VIA+G T D+GGT +TQ+V Sbjct: 297 ANPIAMIWSGALMLEFLGQGDERYQRAHDDMLNAIERVIADGSV-TPDMGGTLSTQQVGA 355 Query: 1206 AV---IAKLD 1226 A+ +A+LD Sbjct: 356 AISDTLARLD 365
>Q5NPQ9:LEU3_ZYMMO 3-isopropylmalate dehydrogenase - Zymomonas mobilis| Length = 349 Score = 120 bits (300), Expect = 2e-26 Identities = 109/358 (30%), Positives = 177/358 (49%), Gaps = 30/358 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM--------HAPVCFETYEVHGDMPSVPTEVIESIRR 398 + L+ GDGIGP +T ++++A+ A + ++V G +P E ++ + Sbjct: 3 IALLAGDGIGPEITAEAVKILKAVVGQEIEFDEALIGGAAWKVTGS--PLPEETLKLCKN 60 Query: 399 NKVCLKGGLATPVGGGVS------SLNLQLRKELDLYASLVNCFNLPGLPTRH---ENV- 548 + L G + P + L LRKELDL+A+L P L EN+ Sbjct: 61 SDAILFGSVGDPECDHLERALRPEQAILGLRKELDLFANLRPARLFPELQAESPLKENIV 120 Query: 549 ---DIAVIRENTEGEYSGL---EHEVVPGVVESLKVMTKFCSE--RIAKYAFEYAYLNNR 704 D+ ++RE T Y G + + E M E RIA+ FE A + Sbjct: 121 TGTDLMIVRELTGDVYFGTPRGQRKDDQNRREGFDTMRYNEDEVKRIARIGFETAR-SRS 179 Query: 705 KKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTP 884 + ++ K+N+++ + L+ E+A +YP ++ + + VDN MQLV P+QFDV+VT Sbjct: 180 GNLCSIDKSNVLETSQ-LWRTVVLEIAQEYPDVELSHMYVDNAAMQLVRAPDQFDVIVTG 238 Query: 885 NLYGNLVSNVA-AGIAXXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVA 1055 NL+G+++S++A A + + ++E G++ G KANP+A Sbjct: 239 NLFGDILSDLASACVGSIGLLPSASLNSEGKGLYEPIHGSAPDIAG------LGKANPLA 292 Query: 1056 LFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 LS AMMLR+ L+ + ADR+E AV + +G RT DLGG TT E+ +AV+A L+ Sbjct: 293 TILSGAMMLRYSLKREADADRIEKAVSTALEKGA-RTADLGGKMTTSEMGNAVLAALN 349
>Q46LE2:LEU3_PROMT 3-isopropylmalate dehydrogenase - Prochlorococcus marinus (strain| NATL2A) Length = 359 Score = 120 bits (300), Expect = 2e-26 Identities = 106/349 (30%), Positives = 163/349 (46%), Gaps = 30/349 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETY---------EVHGDMPSVPTEVIESIR 395 +TL+PGDGIGP +T ++++ + FE + D P ++ + Sbjct: 6 ITLLPGDGIGPEITNVTHKILDLVSRKFGFEIKFKEMPFGGSAIDSDGIPFPDRTLQECK 65 Query: 396 RNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGLPTRH------ 539 + L + P + L LR LDL+A++ +P L Sbjct: 66 NSDAVLLAAIGDPKYDELPREKRPETGLLNLRSSLDLFANIRPVKIIPSLTKASSLKEDF 125 Query: 540 -ENVDIAVIRENTEGEYSGLEHEVVPGVV--ESLKVMTKFCSE--RIAKYAFEYAYLNNR 704 + VD+ V+RE T G Y G + + MT E RIA+ AF+ A N+ Sbjct: 126 VKEVDLVVVRELTSGIYFGEPKGRIKTDKGERAFNTMTYTSEEVNRIAEIAFKLAKQRNQ 185 Query: 705 KKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTP 884 K V +V KAN++ ++ L+ E V+ KY I+ VDN MQLV P QFDV++T Sbjct: 186 K-VCSVDKANVLDVSQ-LWREETILVSNKYKDIELTHQYVDNAAMQLVRNPSQFDVILTG 243 Query: 885 NLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQKKANPVA 1055 NL+G+++S++AA + D VFE G++ G D ANP+A Sbjct: 244 NLFGDILSDIAAMLTGSIGMLPSASLTTDGPGVFEPVHGSAPDIAGKD------IANPIA 297 Query: 1056 LFLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEV 1199 + LS+AMML+ L A LE+A+ ++ +G YRT DL TT++V Sbjct: 298 MLLSAAMMLKIALNETEAATFLENAINEILNDG-YRTSDLMSIQTTKQV 345
>Q5YRX2:LEU3_NOCFA 3-isopropylmalate dehydrogenase - Nocardia farcinica| Length = 335 Score = 119 bits (299), Expect = 3e-26 Identities = 100/347 (28%), Positives = 163/347 (46%), Gaps = 22/347 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV-----HGDMPSVPTEVIESIRRNKV 407 + +IPGDGIGP V +V++ + V Y++ H +P V+ +R + Sbjct: 3 LAVIPGDGIGPEVIAEALKVLDVVVPGVEKTEYDLGAKRYHATGEILPDSVLPELREHDA 62 Query: 408 CLKGGLATP-VGGGVSSLNLQLRK--ELDLYASLVNCFNLPGLPTR---HENVDIAVIRE 569 L G + P V GV L LR ELD + +L G+ + ++D V+RE Sbjct: 63 ILLGAIGDPSVPSGVLERGLLLRTRFELDHHVNLRPSRLFTGVRSPLAGAPDIDFVVVRE 122 Query: 570 NTEGEYSGL--------EHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVH 725 TEG Y+G HEV V + T+F ER+ +YAF A RK +T VH Sbjct: 123 GTEGPYTGTGGAIRVRTPHEVATEVSTN----TRFGIERVVRYAFAKAQAR-RKHLTLVH 177 Query: 726 KANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLV 905 K N++ A L+ + EV ++P + +D + +V P +FDV+VT NL+G+++ Sbjct: 178 KTNVLTFAGSLWQRTVDEVGAEFPEVTVAYQHIDAATIHMVTDPGRFDVIVTDNLFGDII 237 Query: 906 SNVAAGIA---XXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVALFLSSAM 1076 +++AA ++ + ++FE + I Q KA+P A LS ++ Sbjct: 238 TDLAAAVSGGIGLAASGNIDASGTNPSMFEPVHGSA----PDIAGQSKADPTAAILSVSL 293 Query: 1077 MLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIA 1217 +L HL A R+++AV +A GT++T E+ D + A Sbjct: 294 LLNHLGDTEAAARIDAAVAKDLAA-------RSGTASTVEIGDRIAA 333
>P43860:LEU3_HAEIN 3-isopropylmalate dehydrogenase - Haemophilus influenzae| Length = 358 Score = 119 bits (299), Expect = 3e-26 Identities = 110/346 (31%), Positives = 164/346 (47%), Gaps = 31/346 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTG----AVRQVMEAMHAPVCFETYEVHGDMPS-----VPTEVIESIR 395 + ++ GDGIGP V + +V E + F + V G +P E ++ Sbjct: 6 IAVLAGDGIGPEVMAEAIKVLNRVQEKFGFKLNFNEFFVGGAAIEHCGYPLPAETLKGCD 65 Query: 396 RNKVCLKGGLATPVGGGVS-------SLNLQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+ +L GL P R + Sbjct: 66 QADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFCPLRAD 125 Query: 543 ----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 D+ V+RE T G Y G E + V +V K+ ERIA+ AFE A Sbjct: 126 IAAKGFDMVVVRELTGGIYFGQPKGREGDGVQTKAFDTEVYYKYEIERIARAAFEAAMKR 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 N KKVT+V KAN+++ + L+ E+ E+A YP + I +DN MQL+ PE FDV++ Sbjct: 186 N-KKVTSVDKANVLQ-SSILWRETVTEMAKDYPEVTLEHIYIDNATMQLIKSPESFDVLL 243 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE-QGASAGNVGNDKILQQKKANPV 1052 N++G+++S+ AA I ++ ++E G SA ++ I ANP+ Sbjct: 244 CSNIFGDIISDEAAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKGI-----ANPI 298 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST 1187 A LS+AMMLR+ AD +ESAV+ V+A G +RT DL ST Sbjct: 299 AQILSAAMMLRYSFNLNEAADAIESAVQKVLASG-HRTADLADDST 343
>Q7U840:LEU3_SYNPX 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain WH8102)| Length = 357 Score = 119 bits (298), Expect = 3e-26 Identities = 109/344 (31%), Positives = 165/344 (47%), Gaps = 30/344 (8%) Frame = +3 Query: 231 APRTVTLIPGDGIGPLVTGAVRQVMEAMHA----PVCFETYEVHGDM-----PSVPTEVI 383 A V L+PGDGIGP +T RQ++EA+ +CF+ + G +P + Sbjct: 2 AQHRVVLLPGDGIGPEITAVARQLLEAVSQRHGFELCFDGQLIGGSAIDACGEPLPASTL 61 Query: 384 ESIRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL------ 527 ++ + L + +P + L LR + L+A+L +P L Sbjct: 62 DACKAADAVLLAAIGSPRFDNLPRDKRPETGLLGLRSGMALFANLRPVKIVPALIGASSL 121 Query: 528 -PTRHENVDIAVIRENTEGEYSGLEHEVVP--GVVESLKVMTKFCSE--RIAKYAFEYAY 692 P E VD+ V+RE T G Y G + G MT SE RIA+ AF+ A Sbjct: 122 RPEVIEGVDLMVVRELTGGIYFGQPKGRIQADGEERGFNTMTYSSSEVDRIARVAFDLAR 181 Query: 693 LNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDV 872 R + +V KAN++ ++ L+ + +A Y ++ + + VDN MQLV P QFDV Sbjct: 182 -ERRGNLCSVDKANVLDVSQ-LWRDRVDAMAPAYSDVEVSHMYVDNAAMQLVRSPRQFDV 239 Query: 873 MVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQKKA 1043 ++T NL+G+++S+ AA + D +FE G++ G D KA Sbjct: 240 LLTGNLFGDILSDEAAMLTGSIGMLPSASLGSDCPGLFEPVHGSAPDIAGQD------KA 293 Query: 1044 NPVALFLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDL 1172 NP+A+ LS+AMMLR L+ A LE+AV V+A G +RT DL Sbjct: 294 NPMAMVLSAAMMLRIGLKQTEAAADLEAAVDKVLAAG-FRTGDL 336
>P73960:LEU3_SYNY3 3-isopropylmalate dehydrogenase - Synechocystis sp. (strain PCC 6803)| Length = 362 Score = 119 bits (297), Expect = 4e-26 Identities = 113/341 (33%), Positives = 162/341 (47%), Gaps = 31/341 (9%) Frame = +3 Query: 243 VTLIPGDGIGP----LVTGAVRQVMEAMHAPVCFETYEVHG------DMPSVPTEVIESI 392 VTL+PGDGIGP + + +V + F+ + G P + ++ Sbjct: 7 VTLLPGDGIGPEIMAVAVAVLGKVADQFGFAFNFQEALIGGAAIDATGQPLPEATLAQAK 66 Query: 393 RRNKVCLK--GGLA---TPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRH------ 539 + V L GG A P + L +R+ L L+A+L P L Sbjct: 67 DSDAVLLAAIGGYAWDNLPRSQRPETGLLAIREGLGLFANLRPATIFPQLIDASSLKREV 126 Query: 540 -ENVDIAVIRENTEGEYSGLEH---EVVPGVVESLKVMTKFCSE--RIAKYAFEYAYLNN 701 E VDI V+RE T G Y G E G + M E RIAK AFE A Sbjct: 127 VEGVDIMVVRELTGGIYFGKPKGIFETETGEKRGVNTMAYTVGEIDRIAKVAFETAR-KR 185 Query: 702 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 R ++ +V KAN++ ++ L+ + +A YP ++ + + VDN MQLV P QFD +VT Sbjct: 186 RGQLCSVDKANVLDVSQ-LWRDRVMAIAVDYPDVELSHLYVDNAAMQLVRSPRQFDTIVT 244 Query: 882 PNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S++AA + D +FE G++ G D KANP+ Sbjct: 245 GNLFGDILSDIAAMLTGSIGMLPSASLGSDGPGLFEPVHGSAPDIAGQD------KANPL 298 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL 1172 A LS+AMMLR+ L P ADRLE AVK V+ +G YRT D+ Sbjct: 299 AQVLSAAMMLRYGLDQPQAADRLEDAVKKVLEQG-YRTGDI 338
>Q8FVF3:LEU3_BRUSU 3-isopropylmalate dehydrogenase - Brucella suis| Length = 370 Score = 119 bits (297), Expect = 4e-26 Identities = 118/378 (31%), Positives = 173/378 (45%), Gaps = 48/378 (12%) Frame = +3 Query: 231 APRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVC--FET---------YEVHGDMPSVPTE 377 A R + L+PGDGIGP VR+V+ +++ + FET Y+ HG ++ Sbjct: 2 ASRKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAYDAHGQ--AISDA 59 Query: 378 VIESIRRNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGL---- 527 +E L G + P V + L+LRK++ LYA+L P L Sbjct: 60 DMEKALAADAVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 528 ---PTRHENVDIAVIRENTEGEYSGLEHEVVP-------GVVESLKVMTKFCSERIAKYA 677 P E +DI ++RE T G Y G E++ G+ +V + ERIA A Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIIDLGNGQKRGI--DTQVYDTYEIERIADVA 177 Query: 678 FEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKP 857 FE A R KVT++ K N+MK K+ +Q ++ D MQLV P Sbjct: 178 FELAR-TRRNKVTSMEKRNVMKSGVLWNQVVTARHKEKHADVQLEHMLADAGGMQLVRWP 236 Query: 858 EQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQK 1037 +QFDV++T NL+G+L+S+VAA + GA+ G K L + Sbjct: 237 KQFDVILTDNLFGDLLSDVAAMLTGSLGMLPSA---------SLGAADSKTGKRKALYEP 287 Query: 1038 K------------ANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL-- 1172 ANP+A+ S AM LR+ + ADRLE+A+ GV+ +G RT D+ Sbjct: 288 VHGSAPDIAGKGIANPIAMIASLAMCLRYSFGLVAEADRLEAAIAGVLDDG-IRTADIWS 346 Query: 1173 -GGTST-TQEVTDAVIAK 1220 G T T E+ DA++AK Sbjct: 347 EGNTKVGTTEMGDAILAK 364
>Q65GI9:LEU3_BACLD 3-isopropylmalate dehydrogenase - Bacillus licheniformis (strain DSM| 13 / ATCC 14580) Length = 370 Score = 119 bits (297), Expect = 4e-26 Identities = 117/362 (32%), Positives = 180/362 (49%), Gaps = 33/362 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAM--HAPVCFE-TYEVHGDMP------SVPTEVIES 389 + + L+PGDGIGP V A V++++ H FE Y + G +P E + + Sbjct: 3 KRIALLPGDGIGPEVLDAAVDVLKSVAEHYQHEFEFEYGLIGGAAIDEAGAPLPEETVAA 62 Query: 390 IRRNKVCLKGGLATPVGG-GVSSLN-----LQLRKELDLYASL--VNCF-NLPG---LPT 533 + L G + P S L L +RK+LDL+A+L V F +L G L T Sbjct: 63 CKAADAILLGAVGGPKWDQNPSELRPEKGLLAIRKQLDLFANLRPVKVFESLAGASPLKT 122 Query: 534 RH-ENVDIAVIRENTEGEYSGLEHEVVP---GVVESLKVM--TKFCSERIAKYAFEYAYL 695 + E VD ++RE T G Y G E G E++ + K ER+ + AF+ A Sbjct: 123 EYIEGVDFVIVRELTGGLYFGKPSEQYVNQNGEEEAVDTLFYKKSEMERVIREAFQMAQ- 181 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 + + KVT+V KAN+++ + L+ ++ EVA ++P ++ ++VDN MQL+ P QFD++ Sbjct: 182 SRKGKVTSVDKANVLE-SSKLWRKTAEEVAKEFPDVKLEHMLVDNAAMQLIYAPGQFDII 240 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD--HAVFEQGASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ A+ + H SA ++ I ANP Sbjct: 241 VTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHLYEPVHGSAPDIAGQNI-----ANP 295 Query: 1050 VALFLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDLGGTS---TTQEVTDAVIA 1217 +A LS+AMMLR + A +E AV V+ GK RT+DL S TTQ +T V A Sbjct: 296 LAAILSAAMMLRTSFGLEAEAQAVEHAVDQVLRAGK-RTKDLAKGSEHCTTQSITGEVKA 354 Query: 1218 KL 1223 L Sbjct: 355 AL 356
>O66607:LEU3_AQUAE 3-isopropylmalate dehydrogenase - Aquifex aeolicus| Length = 364 Score = 119 bits (297), Expect = 4e-26 Identities = 102/362 (28%), Positives = 173/362 (47%), Gaps = 34/362 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----------HAPVCFETYEVHGDMPSVPTEVIES 389 + ++ GDGIGP + +V++ + + E + GD +P E ++ Sbjct: 6 IAVLKGDGIGPEIVEQALRVLDKIGEIYGVEFEYREGLIGGEAIDKTGD--PLPEETLKI 63 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASL----VNCFNLPGLPTRH 539 + + L G + P + + L++RKELDLYA+L V + P + Sbjct: 64 CKESDAILLGAVGGPKWDNLPTDKRPEKGLLRIRKELDLYANLRPAKVWDALISSSPLKE 123 Query: 540 ENV---DIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSE----RIAKYAFEYAYLN 698 E V D+ VIRE T G Y G + + + T +E RI + FE A Sbjct: 124 EVVKGTDMIVIRELTSGIYYGEPRGIFEENGKRYAINTMKYTEDEIRRIVRKGFEIAR-K 182 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 RKK+T+V KAN+++++ L+ + E YP ++ + +DNC MQLV +P FDV+V Sbjct: 183 RRKKLTSVDKANVLEVS-ALWRQIVEEEKENYPDVELEHLYIDNCAMQLVRRPTSFDVIV 241 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVA 1055 T N++G+++S+ A + +A++E SA ++ I ANP+A Sbjct: 242 TGNIFGDILSDEAGVVVGSLGMLPSASIGDRYALYEPVHGSAPDIAGKGI-----ANPIA 296 Query: 1056 LFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVIAK 1220 LS+AMML++ D +E A++ + +G YRT D+ T+E+TD ++ Sbjct: 297 TILSAAMMLKYSFNMDKAHDLIEKAIEETLNQG-YRTPDIYSEGCIKVGTKEITDKILEN 355 Query: 1221 LD 1226 L+ Sbjct: 356 LE 357
>Q7NFH4:LEU3_GLOVI 3-isopropylmalate dehydrogenase - Gloeobacter violaceus| Length = 362 Score = 118 bits (296), Expect = 6e-26 Identities = 108/348 (31%), Positives = 165/348 (47%), Gaps = 33/348 (9%) Frame = +3 Query: 228 GAPRTVTLIPGDGIGPLVTGAVRQVMEAM-----------HAPVCFETYEVHGDMPSVPT 374 G + ++PGDGIG + ++EA AP+ + G+ +P Sbjct: 2 GGRYKIAVLPGDGIGTEIVQVGVAMLEAAARRFDFAFDFEEAPIGGAAIDATGE--PLPA 59 Query: 375 EVIESIRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL--- 527 +E + + G + P + S L LR L L+A+L LP L Sbjct: 60 ATLELCKASDAVFLGAVGGPQWDTLPSDKRPEKALLGLRAGLGLFANLRPARILPQLVAA 119 Query: 528 ----PTRHENVDIAVIRENTEGEYSGLEHEVVP---GVVESLKVMT--KFCSERIAKYAF 680 P E VDI V+RE T G Y G+ + P G + M+ F ERI + AF Sbjct: 120 SALKPEVVEGVDILVVRELTGGLYFGIPKGIFPEKKGGRRGVNTMSYSAFEIERIGRVAF 179 Query: 681 EYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPE 860 E A R K+ +V KAN+++++ L+ E +A +YP ++ + VDNC MQLV +P Sbjct: 180 EAAR-ERRGKLCSVDKANVLEVSQ-LWREVLVGLAPEYPDVELTHMYVDNCAMQLVRRPR 237 Query: 861 QFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQ-DHAVFE--QGASAGNVGNDKILQ 1031 QFD +VT N++G+++S+ AA + ++E G++ G D Sbjct: 238 QFDTIVTENMFGDILSDEAAMLTGSIGMLPSASLGSGGPGLYEPVHGSAPDIAGQD---- 293 Query: 1032 QKKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL 1172 KANP+A LS AM+LRH L+ P A +E AV+ V+ +G YRT D+ Sbjct: 294 --KANPLAQVLSGAMLLRHSLRQPEAAQAVERAVQTVLEQG-YRTGDI 338
>Q8YCX4:LEU3_BRUME 3-isopropylmalate dehydrogenase - Brucella melitensis| Length = 370 Score = 118 bits (296), Expect = 6e-26 Identities = 118/378 (31%), Positives = 172/378 (45%), Gaps = 48/378 (12%) Frame = +3 Query: 231 APRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVC--FET---------YEVHGDMPSVPTE 377 A R + L+PGDGIGP VR+V+ +++ + FET Y+ HG ++ Sbjct: 2 ASRKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAYDAHGQ--AISDA 59 Query: 378 VIESIRRNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGL---- 527 +E L G + P V L+LRK++ LYA+L P L Sbjct: 60 DMEKALAADAVLFGAVGGPKWDSVPYEVRPEGGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 528 ---PTRHENVDIAVIRENTEGEYSGLEHEVVP-------GVVESLKVMTKFCSERIAKYA 677 P E +DI ++RE T G Y G E++ G+ +V + ERIA A Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIIDLGNGQKRGI--DTQVYDTYEIERIADVA 177 Query: 678 FEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKP 857 FE A R KVT++ K N+MK K+ +Q ++ D MQLV P Sbjct: 178 FELAR-TRRNKVTSMEKRNVMKSGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWP 236 Query: 858 EQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQK 1037 +QFDV++T NL+G+L+S+VAA + GA+ G K L + Sbjct: 237 KQFDVILTDNLFGDLLSDVAAMLTGSLGMLPSA---------SLGAADSKTGKRKALYEP 287 Query: 1038 K------------ANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL-- 1172 ANP+A+ S AM LR+ + ADRLE+A+ GV+ +G RT D+ Sbjct: 288 VHGSAPDIAGKGIANPIAMIASLAMCLRYSFGLVAEADRLEAAIAGVLDDG-IRTADIWS 346 Query: 1173 -GGTST-TQEVTDAVIAK 1220 G T T E+ DA++AK Sbjct: 347 EGNTKVGTTEMGDAILAK 364
>Q579B1:LEU3_BRUAB 3-isopropylmalate dehydrogenase - Brucella abortus| Length = 370 Score = 118 bits (296), Expect = 6e-26 Identities = 119/378 (31%), Positives = 177/378 (46%), Gaps = 48/378 (12%) Frame = +3 Query: 231 APRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVC--FET---------YEVHGDMPSVPTE 377 A R + L+PGDGIGP VR+V+ +++ + FET Y+ HG S + Sbjct: 2 ASRKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAYDAHGQAIS-DAD 60 Query: 378 VIESIRRNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGL---- 527 + +++ + V L G + P V + L+LRK++ LYA+L P L Sbjct: 61 MEKALAADSV-LFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 528 ---PTRHENVDIAVIRENTEGEYSGLEHEVVP-------GVVESLKVMTKFCSERIAKYA 677 P E +DI ++RE T G Y G E++ G+ +V + ERIA A Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIIDLGNGQKRGI--DTQVYDTYEIERIADVA 177 Query: 678 FEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKP 857 FE A R KVT++ K N+MK K+ +Q ++ D MQLV P Sbjct: 178 FELAR-TRRNKVTSMEKRNVMKSGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWP 236 Query: 858 EQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQK 1037 +QFDV++T NL+G+L+S+VAA + GA+ G K L + Sbjct: 237 KQFDVILTDNLFGDLLSDVAAMLTGSLGMLPSA---------SLGAADSKTGKRKALYEP 287 Query: 1038 K------------ANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL-- 1172 ANP+A+ S AM LR+ + ADRLE+A+ GV+ +G RT D+ Sbjct: 288 VHGSAPDIAGKGIANPIAMIASLAMCLRYSFGLVAEADRLEAAIAGVLDDG-IRTADIWS 346 Query: 1173 -GGTST-TQEVTDAVIAK 1220 G T T E+ DA++AK Sbjct: 347 EGNTKVGTTEMGDAILAK 364
>Q2YL58:LEU3_BRUA2 3-isopropylmalate dehydrogenase - Brucella abortus (strain 2308)| Length = 370 Score = 118 bits (296), Expect = 6e-26 Identities = 119/378 (31%), Positives = 177/378 (46%), Gaps = 48/378 (12%) Frame = +3 Query: 231 APRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVC--FET---------YEVHGDMPSVPTE 377 A R + L+PGDGIGP VR+V+ +++ + FET Y+ HG S + Sbjct: 2 ASRKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAYDAHGQAIS-DAD 60 Query: 378 VIESIRRNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGL---- 527 + +++ + V L G + P V + L+LRK++ LYA+L P L Sbjct: 61 MEKALAADSV-LFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 528 ---PTRHENVDIAVIRENTEGEYSGLEHEVVP-------GVVESLKVMTKFCSERIAKYA 677 P E +DI ++RE T G Y G E++ G+ +V + ERIA A Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIIDLGNGQKRGI--DTQVYDTYEIERIADVA 177 Query: 678 FEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKP 857 FE A R KVT++ K N+MK K+ +Q ++ D MQLV P Sbjct: 178 FELAR-TRRNKVTSMEKRNVMKSGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWP 236 Query: 858 EQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQK 1037 +QFDV++T NL+G+L+S+VAA + GA+ G K L + Sbjct: 237 KQFDVILTDNLFGDLLSDVAAMLTGSLGMLPSA---------SLGAADSKTGKRKALYEP 287 Query: 1038 K------------ANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL-- 1172 ANP+A+ S AM LR+ + ADRLE+A+ GV+ +G RT D+ Sbjct: 288 VHGSAPDIAGKGIANPIAMIASLAMCLRYSFGLVAEADRLEAAIAGVLDDG-IRTADIWS 346 Query: 1173 -GGTST-TQEVTDAVIAK 1220 G T T E+ DA++AK Sbjct: 347 EGNTKVGTTEMGDAILAK 364
>Q2KYL5:LEU3_BORA1 3-isopropylmalate dehydrogenase - Bordetella avium (strain 197N)| Length = 358 Score = 118 bits (296), Expect = 6e-26 Identities = 114/360 (31%), Positives = 175/360 (48%), Gaps = 33/360 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM-----PSVPTEVIESIRRNKV 407 + ++PGDGIGP + +V++A++ P+ + +V G +P + + + Sbjct: 5 IAVLPGDGIGPEIVEQAVRVLQALNLPLELQEAKVGGAAFDAFEHPLPPATLGLAKSSHA 64 Query: 408 CLKGGL------ATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGL-------PTRHENV 548 L G + + P L LR+ L L+A+L P L P + Sbjct: 65 VLFGAVGDWKYDSLPREFRPEQAILGLRRALGLFANLRPAILYPELASASSLKPEIVAGL 124 Query: 549 DIAVIRENTEGEYSGLEHEV-------VPGVVESLKVMTKFCSE--RIAKYAFEYAYLNN 701 DI +IRE T Y G V G E M SE RIA FE A N Sbjct: 125 DIIIIRELTGDIYFGTPRGVRSAPDGVFSGEREGYDTMRYAESEVRRIAHVGFETARKRN 184 Query: 702 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 KK+ +V KAN+++ + + + EVA +YP ++ + + VDN MQLV P QFDV+VT Sbjct: 185 -KKLCSVDKANVLETSQ-FWRDIVIEVAREYPDVELSHMYVDNAAMQLVRNPRQFDVIVT 242 Query: 882 PNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGN-DKILQQKKANPVAL 1058 NL+G+++S+ AA + QG + G+ I Q ANP+A Sbjct: 243 GNLFGDILSDEAAMLTGSIGMLPSASLNAS----GQGLYEPSHGSAPDIAGQGIANPLAT 298 Query: 1059 FLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTS--TTQEVTDAVIAKL 1223 LS+AM+LR+ L P+ ADR+E+AV+ V+A+G RT D+ GT+ +T ++ DAV+ L Sbjct: 299 ILSAAMLLRYSLNQPAQADRIEAAVRKVLAQG-LRTADIHEAGTTKVSTSQMGDAVLKAL 357
>P61495:LEU3_THETH 3-isopropylmalate dehydrogenase - Thermus thermophilus| Length = 345 Score = 118 bits (295), Expect = 7e-26 Identities = 105/351 (29%), Positives = 163/351 (46%), Gaps = 24/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP----VCFETYEVHGDMPSV-----PTEVIESIR 395 V ++PGDGIGP VT A +V+ A+ + +E + G P + + Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVE 62 Query: 396 RNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGL----PTRHE- 542 + L G + P G+ + L LRK DL+A+L PGL P + E Sbjct: 63 EAEAVLLGSVGGPKWDGLPRKISPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEI 122 Query: 543 --NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVT 716 VD+ ++RE T G Y G + + + +K ER+A+ AFE A RK V Sbjct: 123 ARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAAR-KRRKHVV 181 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 +V KAN++++ + + ++ EV YP + VD M LV P +FDV+VT N++G Sbjct: 182 SVDKANVLEVGE-FWRKTVEEVGRGYPDVALEHQYVDAAAMHLVRSPARFDVVVTGNIFG 240 Query: 897 NLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSA 1073 +++S++A+ + + VFE SA ++ I ANP A LS+A Sbjct: 241 DILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGI-----ANPTAAILSAA 295 Query: 1074 MMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 MML H A ++E AV + E DLGG++ T+ T V+ L Sbjct: 296 MMLEHAFGLVELARKVEDAVAKALLETP--PPDLGGSAGTEAFTATVLRHL 344
>Q49Z13:LEU3_STAS1 3-isopropylmalate dehydrogenase - Staphylococcus saprophyticus subsp.| saprophyticus (strain ATCC 15305 / DSM 20229) Length = 346 Score = 118 bits (295), Expect = 7e-26 Identities = 104/349 (29%), Positives = 161/349 (46%), Gaps = 26/349 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV------------HGDMPSVPTEVIE 386 + +PGDGIGP + ++++ + FE YE+ HG +P + Sbjct: 5 IVALPGDGIGPEILNGSLEILQQLSKEFHFE-YELESHDFGGIAIDNHGK--PLPDSTLN 61 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLNLQ----LRKELDLYASLVNCFNLPGL----PTRHE 542 + + L G + P ++ Q +RK L L+A++ G P + E Sbjct: 62 ACKNADAILLGAVGGPKWTDPNNRPEQGLLGIRKALGLFANIRPTTVTNGTSHLSPIKEE 121 Query: 543 ---NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKV 713 N D ++RE T G Y G ++ T+ ERIA+ FE A KK+ Sbjct: 122 RVANTDFILVRELTGGIYFGEPKQLSENDALDSLTYTRDEIERIARVGFELAQ-KRHKKL 180 Query: 714 TAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 893 T+V K N++ + L+ EV+ YP ++ N ++VD C M L+ P QFDV+VT NL+ Sbjct: 181 TSVDKENVLS-SSKLWRNVINEVSQSYPDVEVNHLLVDACAMHLITNPSQFDVIVTENLF 239 Query: 894 GNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLS 1067 G+++S+ A+ I Q ++E SA ++ N I ANP + LS Sbjct: 240 GDILSDEASVIPGSLGLSPSASFSEQGPRLYEPIHGSAPDIANQDI-----ANPFGMLLS 294 Query: 1068 SAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAV 1211 AM LR L AD+LE+ + +I EGK TRDL G T E+ + V Sbjct: 295 VAMCLRESLNEDKAADKLENVIYQLIKEGK-TTRDLNGNYLTSEIFNYV 342
>Q5SIY4:LEU3_THET8 3-isopropylmalate dehydrogenase - Thermus thermophilus (strain HB8 /| ATCC 27634 / DSM 579) Length = 345 Score = 117 bits (294), Expect = 1e-25 Identities = 105/351 (29%), Positives = 163/351 (46%), Gaps = 24/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP----VCFETYEVHGDMPSV-----PTEVIESIR 395 V ++PGDGIGP VT A +V+ A+ + +E + G P + + Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVE 62 Query: 396 RNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGL----PTRHE- 542 + L G + P G+ + L LRK DL+A+L PGL P + E Sbjct: 63 EAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEI 122 Query: 543 --NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVT 716 VD+ ++RE T G Y G + + + +K ER+A+ AFE A RK V Sbjct: 123 ARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAAR-KRRKHVV 181 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 +V KAN++++ + + ++ EV YP + VD M LV P +FDV+VT N++G Sbjct: 182 SVDKANVLEVGE-FWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFG 240 Query: 897 NLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSA 1073 +++S++A+ + + VFE SA ++ I ANP A LS+A Sbjct: 241 DILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGI-----ANPTAAILSAA 295 Query: 1074 MMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 MML H A ++E AV + E DLGG++ T+ T V+ L Sbjct: 296 MMLEHAFGLVELARKVEDAVAKALLETP--PPDLGGSAGTEAFTATVLRHL 344
>P61494:LEU3_THET2 3-isopropylmalate dehydrogenase - Thermus thermophilus (strain HB27 /| ATCC BAA-163 / DSM 7039) Length = 345 Score = 117 bits (294), Expect = 1e-25 Identities = 104/351 (29%), Positives = 163/351 (46%), Gaps = 24/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP----VCFETYEVHGDMPSV-----PTEVIESIR 395 V ++PGDGIGP VT A +V+ A+ + +E + G P + + Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVE 62 Query: 396 RNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGL----PTRHE- 542 + L G + P G+ + L LRK DL+A+L PGL P + E Sbjct: 63 EAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEI 122 Query: 543 --NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVT 716 VD+ ++RE T G Y G + + + +K ER+A+ AFE A RK V Sbjct: 123 ARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAAR-KRRKHVV 181 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 +V KAN++++ + + ++ EV YP + VD M LV P +FDV+VT N++G Sbjct: 182 SVDKANVLEVGE-FWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFG 240 Query: 897 NLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSA 1073 +++S++A+ + + VFE SA ++ + ANP A LS+A Sbjct: 241 DILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGL-----ANPTAAILSAA 295 Query: 1074 MMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 MML H A ++E AV + E DLGG++ T+ T V+ L Sbjct: 296 MMLEHAFGLVELARKVEDAVAKALLEAP--PPDLGGSAGTEAFTATVLRHL 344
>Q4L7U1:LEU3_STAHJ 3-isopropylmalate dehydrogenase - Staphylococcus haemolyticus (strain| JCSC1435) Length = 346 Score = 117 bits (294), Expect = 1e-25 Identities = 101/343 (29%), Positives = 166/343 (48%), Gaps = 24/343 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE----TYEVHG---DMPSVPT--EVIESIR 395 + +PGDGIGP + +++E + F+ +Y+ G D VP + + + + Sbjct: 5 IVALPGDGIGPEILSGTLELLELISKKYKFDYQLTSYDFGGAAIDSHGVPLPDDTLNACK 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASL--------VNCFNLPGLPTRH 539 L G + P ++ L LRK L L+A++ + F+ P +R Sbjct: 65 NADAILLGAVGGPQWTDPNNRPEQGLLALRKSLGLFANIRPTKVTEGTSHFS-PIKESRV 123 Query: 540 ENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTA 719 + D ++RE T G Y G + TK ERIA AFE A +KK+T+ Sbjct: 124 KGTDFIIVRELTSGLYFGEPRHIDNQSALDSLTYTKKEIERIAMVAFELAS-QRKKKLTS 182 Query: 720 VHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGN 899 V K N++ + L+ ++ E++ ++P ++ N ++VD C MQL+++P FDV+VT NL+G+ Sbjct: 183 VDKENVLATSK-LWRKTINEISHEFPDVKVNHLLVDACSMQLISQPTNFDVIVTENLFGD 241 Query: 900 LVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSA 1073 ++S+ A+ I + ++E SA ++ N Q ANP + LS A Sbjct: 242 ILSDEASTIPGSLGLSPSASFSLEGPRLYEPIHGSAPDIAN-----QNLANPFGMILSLA 296 Query: 1074 MMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEV 1199 M LR F A LE AV +I +GK T+DL G TT ++ Sbjct: 297 MCLRESFNFEDAASELEQAVYQLIKDGK-TTKDLNGHYTTSDI 338
>Q3APC4:LEU3_CHLCH 3-isopropylmalate dehydrogenase - Chlorobium chlorochromatii (strain| CaD3) Length = 352 Score = 117 bits (294), Expect = 1e-25 Identities = 108/360 (30%), Positives = 173/360 (48%), Gaps = 33/360 (9%) Frame = +3 Query: 243 VTLIPGDGIGP-LVTGAV---RQVMEAMHAPVCFE-------TYEVHGDMPSVPTEVIES 389 + IPGDGIG +V GAV RQ+ + V E +Y+VHG+M + T +E+ Sbjct: 5 IVSIPGDGIGTEVVAGAVAVLRQLEKKYGFTVEIEEHLFGGASYDVHGEMLTDAT--LEA 62 Query: 390 IRRNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASL---------VNCFNLPG 524 + L G + P + + L++RKEL L+A+L V+ +L Sbjct: 63 CKNCDAVLLGAVGGPKWENLPHEHKPEAALLKIRKELGLFANLRPAKVYDALVDASSLKA 122 Query: 525 LPTRHENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNR 704 R D V RE T G Y G + V K+ ERIA+ AFE A + Sbjct: 123 DVVR--GTDFVVFRELTGGIYFGQPRGYDENKGWNTMVYEKYEVERIARLAFEAAR-QRQ 179 Query: 705 KKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTP 884 +V ++ KAN+++++ L+ V Y ++ +++ VDN MQ+V P+QFDV+VT Sbjct: 180 GRVMSIDKANVLEVSQ-LWRNVVHAVHADYQDVELSDMYVDNAAMQIVRNPKQFDVIVTG 238 Query: 885 NLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPVAL 1058 NL+G+++S+++ I HA++E G++ G Q KANP+A Sbjct: 239 NLFGDILSDISGMITGSLGMLPSASIGSKHALYEPIHGSAPDIAG------QNKANPIAT 292 Query: 1059 FLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS----TTQEVTDAVIAKL 1223 S AMM H + A +E A++ +A G RT D+ +T +T+A+I++L Sbjct: 293 IASVAMMFEHSFKRTDIARDIEQAIEAALATG-VRTADIAAAGDTAVSTTAMTEAIISQL 351
>Q24XT2:LEU3_DESHY 3-isopropylmalate dehydrogenase - Desulfitobacterium hafniense| (strain Y51) Length = 352 Score = 117 bits (293), Expect = 1e-25 Identities = 111/361 (30%), Positives = 174/361 (48%), Gaps = 34/361 (9%) Frame = +3 Query: 243 VTLIPGDGIG----PLVTGAVRQVMEAMHAPVCFETYEVHGDM-----PSVPTEVIESIR 395 + ++PGDGIG P ++ V+ A F+ Y + G ++P E ++ R Sbjct: 4 IAVLPGDGIGQEIIPQAVRVLKAVLAETDAEFEFQDYPIGGAAIELVGKALPDETLQGCR 63 Query: 396 RNKVCLKGGLATPVGGGV-----------SSLNLQLRKELDLYASLVNCFNLPGL---PT 533 L G VGG ++ L LRK L+ YA++ +P L T Sbjct: 64 EADAVLLGA----VGGHQWDHLPASERPETAALLGLRKGLNFYANIRPVRMIPSLLATST 119 Query: 534 RHENV----DIAVIRENTEGEYSGLE-HEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 ENV D+ VIRE T G Y G + P ++ RI FE A L Sbjct: 120 LKENVLDGVDMVVIRELTGGVYFGEKGRSDNPRSAYDKMTYSEEEIRRILIQGFETAMLR 179 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 + KK+ +V KAN+++ + L+ E E+A +YP ++ + VDN MQLV P+QFDV+V Sbjct: 180 S-KKLCSVDKANVLETSR-LWREIANELAKEYPEVELTHMYVDNAAMQLVRNPKQFDVIV 237 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQG-ASAGNVGNDKILQQKKANPVA 1055 T N++G++++++A+ + ++E SA ++ + ANP+A Sbjct: 238 TENMFGDILTDLASMLGGSIGMLSSASLSGTQGMYEPAHGSAPDIAGKNL-----ANPLA 292 Query: 1056 LFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVIAK 1220 LS+A+MLR+ + A R+ESAV+ V+ +G YRT DL T E+ DAV+A Sbjct: 293 TILSAALMLRYSFGMEAEALRIESAVEKVLEQG-YRTGDLAQAGDKVVGTIEMGDAVLAA 351 Query: 1221 L 1223 L Sbjct: 352 L 352
>Q9K8E9:LEU3_BACHD 3-isopropylmalate dehydrogenase - Bacillus halodurans| Length = 363 Score = 117 bits (293), Expect = 1e-25 Identities = 109/361 (30%), Positives = 183/361 (50%), Gaps = 35/361 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM----------PSVPTEVIE 386 + + ++PGDGIGP VT A +V++A+ A T+ + +P E ++ Sbjct: 3 KQIAVLPGDGIGPEVTDAAIEVLQAV-ADRFGHTFSYKKALLGGCAIDEVGTPLPEETLD 61 Query: 387 SIRRNKVCLKGGLATP----VGGGVSSLN--LQLRKELDLYASL--VNCFNLPGLPTRHE 542 R L G + P + G + L LRK L+L+A+L V ++ + + Sbjct: 62 VCRHADGILLGAVGGPKWDTLPGHLRPEKGLLGLRKGLNLFANLRPVTVYDSLADASTLK 121 Query: 543 N-----VDIAVIRENTEGEYSGLEHE-----VVPGVVESLKVMTKFCSERIAKYAFEYAY 692 N VD+ ++RE T G Y G E VV++L + T+ RI + AFE A Sbjct: 122 NDVIDGVDLLIVRELTGGLYFGEPRERRGEGETEEVVDTL-LYTRGEMRRIIRKAFELAM 180 Query: 693 LNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDV 872 + N K VT+V KAN+++ + ++ E EVA ++P + ++VDN MQL+ +P+QFDV Sbjct: 181 VRN-KHVTSVDKANVLE-SSRMWREVANEVAQEFPEVTLEHMLVDNAAMQLIRRPKQFDV 238 Query: 873 MVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQ-GASAGNVGNDKILQQKKAN 1046 +VT NL+G+++S+ A+ + D ++E SA ++ + AN Sbjct: 239 LVTENLFGDILSDEASMVTGSLGMLPSASLTSDGPGLYEPIHGSAPDIAGKGV-----AN 293 Query: 1047 PVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLG----GTSTTQEVTDAV 1211 P+A S AMML++ A +E A++ V+ +G YRT D+ +S+T+ +TDAV Sbjct: 294 PLATIASCAMMLKYSFGLHEEAKTIEDAIEAVLKQG-YRTADIAKPGEESSSTKAITDAV 352 Query: 1212 I 1214 + Sbjct: 353 V 353
>Q4QLS3:LEU3_HAEI8 3-isopropylmalate dehydrogenase - Haemophilus influenzae (strain| 86-028NP) Length = 358 Score = 117 bits (292), Expect = 2e-25 Identities = 111/346 (32%), Positives = 161/346 (46%), Gaps = 31/346 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTG----AVRQVMEAMHAPVCFETYEVHGDMPS-----VPTEVIESIR 395 V ++ GDGIGP V + +V E + F + V G +P E ++ Sbjct: 6 VAVLAGDGIGPEVMAEAMKVLNKVQEKFGFKLNFNEFFVGGAAIDHCGYPLPAETLKGCD 65 Query: 396 RNKVCLKGGLATPVGGGVS-------SLNLQLRKELDLYASLVNCFNLPGL----PTRHE 542 L G + P + L LRK L+ +L GL P R + Sbjct: 66 EADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFCPLRAD 125 Query: 543 ----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 D+ V+RE T G Y G E E +V K+ ERIA+ AFE A Sbjct: 126 IAAKGFDMVVVRELTGGIYFGQPKGREGEGSQTKAFDTEVYYKYEIERIARAAFEAAMKR 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 N KKVT+V KAN+++ + L+ E+ E+A YP + I +DN MQL+ PE FDV++ Sbjct: 186 N-KKVTSVDKANVLQ-SSILWRETVTEMAKDYPEVTLEHIYIDNATMQLIKAPESFDVLL 243 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQ-DHAVFE-QGASAGNVGNDKILQQKKANPV 1052 N++G+++S+ AA I + ++E G SA ++ I ANP+ Sbjct: 244 CSNIFGDIISDEAAMITGSMGMLPSASLNEAGFGLYEPAGGSAPDIAGKGI-----ANPI 298 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST 1187 A LS+AMMLR+ AD +ESAV+ V+A G +RT DL ST Sbjct: 299 AQILSAAMMLRYSFNLNEAADAIESAVQKVLASG-HRTADLADDST 343
>Q30RK2:LEU3_THIDN 3-isopropylmalate dehydrogenase - Thiomicrospira denitrificans| (strain ATCC 33889 / DSM 1351) Length = 355 Score = 116 bits (291), Expect = 2e-25 Identities = 106/336 (31%), Positives = 165/336 (49%), Gaps = 26/336 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE-----------TYEVHGDMPSVPTEVIES 389 + LI GDGIGP + +V++A+ + E Y++ GD +P E I Sbjct: 6 IALIKGDGIGPEIIDEAVKVLDAVASCCDLEFSYEEALMGGCAYDITGD--PLPQETINI 63 Query: 390 IRRNKVCLKGGLA------TPVGGGVSSLNLQLRKELDLYASL--VNCF----NLPGLPT 533 + L G + P S L+ RKEL +YA+L N F N L Sbjct: 64 SLNSDAVLFGAIGGAKWDNLPREKRPESGLLRFRKELGVYANLRPANVFDELINASSLKA 123 Query: 534 RH-ENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKK 710 + VD+ V+RE G Y G + V T+ RIA AF+ A ++ K+ Sbjct: 124 EVIKGVDLMVVRELIGGIYFGEPKGRDENRGWNTMVYTREEIVRIAHQAFKIA-MSRSKR 182 Query: 711 VTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNL 890 V ++ KAN++ ++ L+ E EVA +YP ++ + VDN MQL+ P QFDVM+T N+ Sbjct: 183 VCSIDKANVLDVSQ-LWREVVIEVAKEYPEVELTHMYVDNAAMQLIRDPRQFDVMLTGNI 241 Query: 891 YGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLS 1067 +G+++S+ A+ ++ V+E SA ++ I ANP+A LS Sbjct: 242 FGDILSDEASMLSGSIGLLPSASVGAKIGVYEPIHGSAPDIAGQGI-----ANPIATILS 296 Query: 1068 SAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL 1172 ++MMLR+ L AD++++AVK + EG YRT+DL Sbjct: 297 ASMMLRYALGEHGAADKIDAAVKRALKEG-YRTKDL 331
>Q5KWJ4:LEU3_GEOKA 3-isopropylmalate dehydrogenase - Geobacillus kaustophilus| Length = 371 Score = 116 bits (291), Expect = 2e-25 Identities = 116/369 (31%), Positives = 171/369 (46%), Gaps = 36/369 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE-TYE--------VHGDMPSVPTEVIESIR 395 + ++PGDGIG VT +V++A+ E T+E + +P E + R Sbjct: 6 IAVLPGDGIGKEVTSGAVEVLKAVGIRFGHEFTFEYGLIGGAAIDEAGTPLPEETLRLCR 65 Query: 396 RNKVCLKGGLATPVGGGVSSLN----------LQLRKELDLYASL--VNCFNL-----PG 524 + L G VGG N L +RK+LDLYA+L V C++ P Sbjct: 66 ESDAVLLGA----VGGPKWDDNPPHLRPEKGLLAIRKQLDLYANLRPVVCYDSLVSASPL 121 Query: 525 LPTRHENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCS----ERIAKYAFEYAY 692 P + VD ++RE T G Y G V E V T ERI + AF A Sbjct: 122 KPDLVQGVDFVIVRELTGGIYFGQPSGRVVENGEEKAVDTLLYKKEEIERIVRMAFILAR 181 Query: 693 LNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDV 872 +KKVT+V KAN++ + L+ E EVA ++P + ++VDN MQL+ P+QFDV Sbjct: 182 -GRKKKVTSVDKANVLS-SSRLWREVAEEVAKQFPDVTLEHMLVDNAAMQLIRAPKQFDV 239 Query: 873 MVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPV 1052 +VT N++G+++S+ A+ ++ + I KANP+ Sbjct: 240 IVTENMFGDILSDEASMLSGSLGMLPSASLSASGPSLYEPVHG---SAPDIAGMNKANPI 296 Query: 1053 ALFLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDL---GG--TSTTQEVTDAVI 1214 A LS+AMMLR + A+ +E AV+ + +G RT DL GG ST + V + Sbjct: 297 AAILSAAMMLRLSFGLTAEAEAVEHAVRQALDQG-LRTADLAPSGGRIVSTNEMVEEIKT 355 Query: 1215 AKLD*PPIA 1241 A LD IA Sbjct: 356 AVLDYTAIA 364
>P42958:TTUC_BACSU Probable tartrate dehydrogenase/decarboxylase - Bacillus subtilis| Length = 354 Score = 116 bits (290), Expect = 3e-25 Identities = 99/352 (28%), Positives = 167/352 (47%), Gaps = 25/352 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEA---MHAPVCF---------ETYEVHGDMPSVPTEVIE 386 + IPGDG+G V A +V+ +H + F + Y HG M +P + I Sbjct: 8 IAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTAFPWSCDYYLEHGKM--MPEDGIH 65 Query: 387 SIRRNKVCLKGGLATP--VGGGVS--SLNLQLRKELDLYASLVNCFNLPGL--PTRHEN- 545 ++ + + G + P V +S L L++R+EL+L ++ + G+ P H N Sbjct: 66 TLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPLLHPND 125 Query: 546 VDIAVIRENTEGEYS---GLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVT 716 D VIREN+EGEYS G H + V T+ +ER+ ++AFE A R VT Sbjct: 126 FDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVFTRKATERVMRFAFELAK-KRRSHVT 184 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 + K+N + A + E ++ A Y GI+ + +D V +PE FDV+V L+G Sbjct: 185 SATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQHIDALAAFFVTRPETFDVIVASKLFG 244 Query: 897 NLVSNVAAGIAXXXXXXXXXXXXQD---HAVFEQGASAGNVGNDKILQQKKANPVALFLS 1067 ++++++++ + ++FE + I Q ANP+ + Sbjct: 245 DILTDISSSLMESIGIAPPANINPSGKYPSMFEPVHGSA----PDIAGQGLANPIGQIWT 300 Query: 1068 SAMMLRHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 + +ML H ++ ++ V A+G +TRD+GG STT EVTD + ++L Sbjct: 301 AKLMLDHFGEEELGAKILDVMEQVTADG-IKTRDIGGQSTTAEVTDEICSRL 351
>P05645:LEU3_BACSU 3-isopropylmalate dehydrogenase - Bacillus subtilis| Length = 365 Score = 116 bits (290), Expect = 3e-25 Identities = 111/362 (30%), Positives = 171/362 (47%), Gaps = 33/362 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLV----TGAVRQVMEAMHAPVCFETYEVHGDMPS-----VPTEVIES 389 + + L+PGDGIGP V T ++ V E + FE + G +P E + + Sbjct: 3 KRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIGGAAIDEHHNPLPEETVAA 62 Query: 390 IRRNKVCLKGGLATPVGG-GVSSLN-----LQLRKELDLYASLVNCFNLPGLPTRH---- 539 + L G + P +S L L +RK+LDL+A+L L R Sbjct: 63 CKNADAILLGAVGGPKWDQNLSELRPEKGLLSIRKQLDLFANLRPVKVFESLSDRSPLKK 122 Query: 540 ---ENVDIAVIRENTEGEYSGLEHE-VVPGVVESLKVMTKFCS----ERIAKYAFEYAYL 695 +NVD ++RE T G Y G + V E V T F ER+ + F+ A Sbjct: 123 EYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVDTLFYKRTEIERVIREGFKMAAA 182 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 + KVT+V KAN+++ + L+ E +VA ++P ++ ++VDN MQL+ P QFDV+ Sbjct: 183 R-KGKVTSVDKANVLE-SSRLWREVAEDVAQEFPDVKLEHMLVDNAAMQLIYAPNQFDVV 240 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD--HAVFEQGASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ A+ + H SA ++ + ANP Sbjct: 241 VTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHLFEPVHGSAPDIAG-----KGMANP 295 Query: 1050 VALFLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDLGGT---STTQEVTDAVIA 1217 A LS+AM+LR A +E AV V+A GK RTRDL + S+TQ +T+ V A Sbjct: 296 FAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGK-RTRDLARSEEFSSTQAITEEVKA 354 Query: 1218 KL 1223 + Sbjct: 355 AI 356
>Q7MP78:LEU3_VIBVY 3-isopropylmalate dehydrogenase - Vibrio vulnificus (strain YJ016)| Length = 363 Score = 115 bits (289), Expect = 4e-25 Identities = 110/358 (30%), Positives = 170/358 (47%), Gaps = 35/358 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM---HAPVCFETYE-------VHGDMPSVPTEVIESI 392 + ++PGDGIGP V +V++A+ HA + FE E + +P + + Sbjct: 8 IAVLPGDGIGPEVMAQAHKVLDAIEKKHA-IHFEREEHDVGGIAIDNHGCPLPQSTVTAC 66 Query: 393 RRNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRH 539 + L G + P + + L LRK L+ +L GL P R Sbjct: 67 EESDAVLFGSVGGPKWEHLPPNDQPERGALLPLRKHFQLFCNLRPAQIHSGLEAFSPLRA 126 Query: 540 E----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYL 695 + DI V+RE T G Y G E E ++ +F ERIAK AFE A L Sbjct: 127 DISGRGFDIVVVRELTGGIYFGQPKGREGEGANEKAYDTEIYHRFEIERIAKIAFESARL 186 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 RKKV ++ KAN+++ + L+ E E+A YP ++ + + +DN MQL+ P QFDVM Sbjct: 187 R-RKKVCSIDKANVLQ-SSILWREVVEEIAKDYPDVELSHMYIDNATMQLIKDPAQFDVM 244 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE-QGASAGNVGNDKILQQKKANP 1049 + N++G+++S+ A I + ++E G SA ++ I ANP Sbjct: 245 LCSNIFGDIISDECAMITGSMGMLPSASLNESKFGLYEPAGGSAPDIAGKNI-----ANP 299 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS---TTQEVTDAV 1211 VA LS+A+MLR+ L + A +E+AV +A G+ T DL G +T E+ D + Sbjct: 300 VAQILSAALMLRYSLGEEAAAQDIENAVSQALAAGEL-TADLAGDKPALSTAEMGDKI 356
>Q3JCC4:LEU3_NITOC 3-isopropylmalate dehydrogenase - Nitrosococcus oceani (strain ATCC| 19707 / NCIMB 11848) Length = 362 Score = 115 bits (289), Expect = 4e-25 Identities = 113/362 (31%), Positives = 174/362 (48%), Gaps = 37/362 (10%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAM----HAPVCFET-------YEVHGDMPSVPTEVI 383 + + L+ GDGIGP + +V+ A+ V E+ YEV G +P E + Sbjct: 3 KKIALLAGDGIGPEIIAEAVKVLAALGEHGELDVVLESGLIGGAAYEVTGT--PLPAETL 60 Query: 384 ESIRRNKVCLKGGLATPVGGGVSSLNLQLRKE---------LDLYASLVNCFNLPGL--- 527 + + L G + P +L++++R E L L+A+L P L Sbjct: 61 ALAQDSDAILLGAVGGPQW---ETLDIKVRPEKGLLGIRSALGLFANLRPAILYPQLVGA 117 Query: 528 ----PTRHENVDIAVIRENTEGEYSG-------LEHEVVPGVVESLKVMTKFCSERIAKY 674 P +D+ ++RE T G Y G LEH G + V + RIA+ Sbjct: 118 STLKPEVVSGLDLMIVRELTGGIYFGQPRGVCRLEHGERQGF--NTLVYKESEIRRIAQV 175 Query: 675 AFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAK 854 AF A +R+ V +V KAN+++ + L+ E EVA ++P ++ + + VDN MQLV Sbjct: 176 AFTIAMKRDRR-VCSVDKANVLEATE-LWREVMSEVAAEFPEVELSHMYVDNAAMQLVRA 233 Query: 855 PEQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQ-GASAGNVGNDKIL 1028 P+QFDV+VT N++G+++S+ AA + Q ++E SA ++ I Sbjct: 234 PKQFDVVVTTNMFGDILSDCAAMLTGSIGMLPSASLDQSGRGMYEPIHGSAPDIAGQGI- 292 Query: 1029 QQKKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTD 1205 ANP+A LS AMMLR+ L P+ A RLE AV V+ +G RT D+ TTQ T Sbjct: 293 ----ANPLATILSVAMMLRYSLDSPAQATRLEKAVGAVLDQG-LRTPDIYSPGTTQVSTG 347 Query: 1206 AV 1211 A+ Sbjct: 348 AM 349
>Q2J6V8:LEU3_FRASC 3-isopropylmalate dehydrogenase - Frankia sp. (strain CcI3)| Length = 342 Score = 115 bits (289), Expect = 4e-25 Identities = 98/325 (30%), Positives = 158/325 (48%), Gaps = 23/325 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV-----HGDMPSVPTEVIESIRRNKV 407 + +I GDGIGP V +V+ A+H V Y++ H ++P V+E +R + Sbjct: 3 LAVIGGDGIGPEVVAEGLRVLRAVHPKVDTTEYDLGARRWHETGETLPDSVLEELRGHDA 62 Query: 408 CLKGGLATP-VGGGV--SSLNLQLRKELDLYASLVNCFNLPGLPTRHEN---VDIAVIRE 569 L G + P V GV L L+LR E D + +L PG+ + +D+ V+RE Sbjct: 63 ILLGAVGDPGVPSGVLERGLLLRLRFEFDHHVNLRPVRLYPGVRSPLAGDPAIDMIVVRE 122 Query: 570 NTEGEYSGL--------EHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVH 725 TEG Y+G HEV ESL T++ ER+ + AF A R+ +T VH Sbjct: 123 GTEGPYAGAGGVLRKGTPHEVA--TEESLN--TRYGVERVVRDAFRRADRRERRHLTLVH 178 Query: 726 KANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLV 905 K N++ A L+ + EVA ++P ++ + VD M V P +FDV+VT N++G+++ Sbjct: 179 KNNVLTKAGDLWSRTVAEVAPEFPDVRVDYQHVDAASMFFVTDPGRFDVVVTDNMFGDIL 238 Query: 906 SNVAAGIAXXXXXXXXXXXXQD---HAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSA 1073 +++ A I ++FE SA ++ ++ A+P A S A Sbjct: 239 TDIGAAITGGIGLAASGNLDPSGVHPSMFEPVHGSAPDIAGRQL-----ADPTATVASVA 293 Query: 1074 MMLRHLQFPSFADRLESAVKGVIAE 1148 M+L HL A ++E+AV +A+ Sbjct: 294 MLLDHLGHAEEAAKVEAAVASSLAD 318
>P31958:LEU3_CLOPA 3-isopropylmalate dehydrogenase - Clostridium pasteurianum| Length = 357 Score = 115 bits (289), Expect = 4e-25 Identities = 117/366 (31%), Positives = 179/366 (48%), Gaps = 39/366 (10%) Frame = +3 Query: 243 VTLIPGDGIGP-LVTGAVR---QVMEAMHAPVCFETYEVHGDM-----PSVPTEVIESIR 395 + +IPGDGIGP +V AV+ +V E F + GD +P E I+ + Sbjct: 6 IAVIPGDGIGPDIVREAVKIMTKVGEKYDTKFNFVEVKAGGDAIDAYGEPLPKETIDVCK 65 Query: 396 RNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASL--VNCFNL--PGLPTRHE- 542 + L G + P + L LR L LYA+L +N+ P ++E Sbjct: 66 SSAAVLLGAVGGPKWDNLEGSKRPERALLGLRGALGLYANLRPAKVYNVLKSASPLKNEI 125 Query: 543 ---NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSE--------RIAKYAFEYA 689 VD+ V+RE G Y G G E V T F +E RIA AF+ A Sbjct: 126 IDEGVDLLVVRELIGGIYFGDR-----GTKEVNGVETAFDTEKYNVDEVKRIAHSAFKAA 180 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD 869 + RKKVT+V KAN++ A L+ ++ EV+ +YP ++ + + VDN MQLV KP QFD Sbjct: 181 -MKRRKKVTSVDKANVLD-ASRLWRKTVNEVSKEYPEVELSHLYVDNTAMQLVRKPSQFD 238 Query: 870 VMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQKK 1040 V++T N++G+++S+ A+ I +D ++E G++ G D Sbjct: 239 VILTNNIFGDILSDEASMITGSIGMLASSSIREDSFGMYEPIHGSAPDIAGLD------I 292 Query: 1041 ANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTD 1205 ANP+A LS+AM++ + L A +E+AV+ V+ EG YRT D+ T T E+ + Sbjct: 293 ANPLAQILSAAMLMEYSLDMSEAARDVEAAVEKVLNEG-YRTADIYIEGTKKVGTSEMGN 351 Query: 1206 AVIAKL 1223 V+ +L Sbjct: 352 LVLERL 357
>Q7W929:LEU3_BORPA 3-isopropylmalate dehydrogenase - Bordetella parapertussis| Length = 358 Score = 115 bits (289), Expect = 4e-25 Identities = 114/360 (31%), Positives = 170/360 (47%), Gaps = 33/360 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM-----PSVPTEVIESIRRNKV 407 + ++PGDGIGP + +V++A+ P+ V G +P +E + + Sbjct: 5 IAVLPGDGIGPEIVEQAERVLKALDLPLELRQAPVGGAAFDQFEHPLPPATLELAQGSHA 64 Query: 408 CLKGGLAT------PVGGGVSSLNLQLRKELDLYASLVNCFNLPGL-------PTRHENV 548 L G + P L LRK L L+A+L P L P + Sbjct: 65 VLFGAVGDWKYDTLPREFRPEQAILGLRKALGLFANLRPAILYPELASASSLKPEIVSGL 124 Query: 549 DIAVIRENTEGEYSGLEHEV-------VPGVVESLKVMTKFCSE--RIAKYAFEYAYLNN 701 DI +IRE T Y G V G E M SE RIA+ FE A N Sbjct: 125 DILIIRELTGDIYFGTPRGVRTAADGAFAGEREGYDTMRYAESEVRRIARIGFESARKRN 184 Query: 702 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 KK+ +V KAN+++ + + + EV+ YP ++ + + VDN MQLV P QFDV+VT Sbjct: 185 -KKLCSVDKANVLETSQ-FWRDLVIEVSRDYPDVELSHMYVDNAAMQLVRNPRQFDVIVT 242 Query: 882 PNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGN-DKILQQKKANPVAL 1058 NL+G+++S+ AA + QG + G+ I Q ANP+A Sbjct: 243 GNLFGDILSDEAAMLTGSIGMLPSASLN----AAGQGLYEPSHGSAPDIAGQGIANPLAT 298 Query: 1059 FLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTS--TTQEVTDAVIAKL 1223 LS+AM+LR+ L ADR+E+AV+ V+A+G RT D+ GT+ +T ++ DAV+ L Sbjct: 299 ILSAAMLLRYSLNLAPQADRVEAAVRKVLADG-LRTADIHEAGTTKVSTSQMGDAVLKAL 357
>Q7WKH4:LEU32_BORBR 3-isopropylmalate dehydrogenase 2 - Bordetella bronchiseptica| (Alcaligenes bronchisepticus) Length = 358 Score = 115 bits (289), Expect = 4e-25 Identities = 114/360 (31%), Positives = 170/360 (47%), Gaps = 33/360 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM-----PSVPTEVIESIRRNKV 407 + ++PGDGIGP + +V++A+ P+ V G +P +E + + Sbjct: 5 IAVLPGDGIGPEIVEQAERVLKALDLPLELRQAPVGGAAFDQFEHPLPPATLELAQGSHA 64 Query: 408 CLKGGLAT------PVGGGVSSLNLQLRKELDLYASLVNCFNLPGL-------PTRHENV 548 L G + P L LRK L L+A+L P L P + Sbjct: 65 VLFGAVGDWKYDTLPREFRPEQAILGLRKALGLFANLRPAILYPELASASSLKPEIVSGL 124 Query: 549 DIAVIRENTEGEYSGLEHEV-------VPGVVESLKVMTKFCSE--RIAKYAFEYAYLNN 701 DI +IRE T Y G V G E M SE RIA+ FE A N Sbjct: 125 DILIIRELTGDIYFGTPRGVRTAADGAFAGEREGYDTMRYAESEVRRIARIGFESARKRN 184 Query: 702 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 KK+ +V KAN+++ + + + EV+ YP ++ + + VDN MQLV P QFDV+VT Sbjct: 185 -KKLCSVDKANVLETSQ-FWRDLVIEVSRDYPDVELSHMYVDNAAMQLVRNPRQFDVIVT 242 Query: 882 PNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGN-DKILQQKKANPVAL 1058 NL+G+++S+ AA + QG + G+ I Q ANP+A Sbjct: 243 GNLFGDILSDEAAMLTGSIGMLPSASLN----AAGQGLYEPSHGSAPDIAGQGIANPLAT 298 Query: 1059 FLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTS--TTQEVTDAVIAKL 1223 LS+AM+LR+ L ADR+E+AV+ V+A+G RT D+ GT+ +T ++ DAV+ L Sbjct: 299 ILSAAMLLRYSLNLAPQADRVEAAVRKVLADG-LRTADIHEAGTTKVSTSQMGDAVLKAL 357
>Q8Y5R8:LEU3_LISMO 3-isopropylmalate dehydrogenase - Listeria monocytogenes| Length = 350 Score = 115 bits (288), Expect = 5e-25 Identities = 106/355 (29%), Positives = 174/355 (49%), Gaps = 27/355 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGD----------MPSVPTEVIESI 392 +T + GDGIGP + + QV+EA+ A T+E+ +P+ +++ Sbjct: 5 ITSLAGDGIGPEIMTSGLQVLEAV-AKKYNHTFEIESHPFGGAGIDVAQDPIPSSTLKAC 63 Query: 393 RRNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGLPTRH------- 539 + L G + P L LRK L L+A+ + +P T Sbjct: 64 QDADAILLGAIGGPKWDNAPKRPEDGLLALRKALGLFAN-IRPIQVPSSITHLSPLKKEI 122 Query: 540 -ENVDIAVIRENTEGEYSGL-EHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKV 713 EN D V+RE T G Y G +H V+SL T+ ERI + AFE A N KKV Sbjct: 123 VENTDFVVVRELTGGLYFGEPKHWDESAAVDSL-TYTRAEIERIIEKAFEIAATRN-KKV 180 Query: 714 TAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 893 T+V KAN++ + L+ + EVA+++P I + +D M ++ +P FDV+VT NL+ Sbjct: 181 TSVDKANVLA-SSKLWRKIAEEVASRHPDITLEHLYIDAAAMLMIQRPTTFDVIVTENLF 239 Query: 894 GNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQ-GASAGNVGNDKILQQKKANPVALFLS 1067 G+++S+ A+ I ++ +++E SA ++ N I ANP+++ S Sbjct: 240 GDILSDEASVITGSLGMLPSASHAENGPSLYEPIHGSAPDIANQNI-----ANPMSMISS 294 Query: 1068 SAMMLRHLQFPSF--ADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 +MMLR F F AD +++A + G + T DLGG +TT + T+ V+ +++ Sbjct: 295 VSMMLRQ-SFSLFKEADAIDAAATRTMQAG-FLTADLGGNTTTTDFTNEVLKQIE 347
>Q8DEE0:LEU3_VIBVU 3-isopropylmalate dehydrogenase - Vibrio vulnificus| Length = 363 Score = 115 bits (287), Expect = 6e-25 Identities = 110/358 (30%), Positives = 170/358 (47%), Gaps = 35/358 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM---HAPVCFETYE-------VHGDMPSVPTEVIESI 392 + ++PGDGIGP V +V++A+ HA + FE E + +P + + Sbjct: 8 IAVLPGDGIGPEVMAQAHKVLDAIEKKHA-IHFEREEHDVGGIAIDNHGCPLPQSTVTAC 66 Query: 393 RRNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRH 539 + L G + P + + L LRK L+ +L GL P R Sbjct: 67 EESDAVLFGSVGGPKWEHLPPNDQPERGALLPLRKHFQLFCNLRPAQIHSGLEAFSPLRA 126 Query: 540 E----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYL 695 + DI V+RE T G Y G E E ++ +F ERIAK AFE A L Sbjct: 127 DISGRGFDIVVVRELTGGIYFGQPKGREGEGANEKAYDTEIYHRFEIERIAKIAFESARL 186 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 RKKV ++ KAN+++ + L+ E E+A YP ++ + + +DN MQL+ P QFDVM Sbjct: 187 R-RKKVCSIDKANVLQ-SSILWREVVEELAKDYPDVELSHMYIDNATMQLIKDPAQFDVM 244 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE-QGASAGNVGNDKILQQKKANP 1049 + N++G+++S+ A I + ++E G SA ++ I ANP Sbjct: 245 LCSNIFGDIISDECAMITGSMGMLPSASLNESKFGLYEPAGGSAPDIAGKNI-----ANP 299 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS---TTQEVTDAV 1211 VA LS+A+MLR+ L + A +E+AV +A G+ T DL G +T E+ D + Sbjct: 300 VAQILSAALMLRYSLGEEAAAQDIENAVSQALAAGEL-TADLAGDKPALSTAEMGDKI 356
>Q97EE2:LEU3_CLOAB 3-isopropylmalate dehydrogenase - Clostridium acetobutylicum| Length = 357 Score = 115 bits (287), Expect = 6e-25 Identities = 113/361 (31%), Positives = 171/361 (47%), Gaps = 34/361 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFETYEVHGDMPSV-------PTEVIESIR 395 V +IPGDGIG + G +V+E + A F EV ++ P E +E + Sbjct: 6 VAVIPGDGIGVEIVGEALKVLEKVGAKYDTKFNFTEVKAGGCAIDEFGVPLPNETLEICK 65 Query: 396 RNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASL----VNCFNLPGLPTRHE- 542 + L G + P + + LR L LYA+L V P + E Sbjct: 66 NSDAVLLGAVGGPKWDTLPGEKRPEKALMGLRGGLGLYANLRPAKVYDILKSASPLKEEI 125 Query: 543 ---NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSE---RIAKYAFEYAYLNNR 704 VD+ V+RE T G Y G + + S ++ E RIA AF+ A L Sbjct: 126 INKGVDLLVVRELTGGIYFGERGRDIQNGINSAYDTERYNVEEIKRIAHVAFKAA-LKRN 184 Query: 705 KKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTP 884 KKVT+V KANI++ + L+ E+ EVA +YP ++ N + VDN MQLV +P QFDV+VT Sbjct: 185 KKVTSVDKANILE-SSRLWRETVTEVAKEYPEVELNYLYVDNAAMQLVREPSQFDVIVTS 243 Query: 885 NLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQKKANPVA 1055 N++G+++++ A+ + D ++E G++ G D ANP+A Sbjct: 244 NIFGDILTDEASMVTGSIGMLPSASLRNDTFGMYEPIHGSAPDIAGQD------LANPLA 297 Query: 1056 LFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVIAK 1220 LS AMML + A +E AV+ V+ G YRT D+ + T+E+ V+A+ Sbjct: 298 QILSVAMMLEYSFNMTEAARDVEDAVEKVLNSG-YRTGDIYTEGSKKVGTKEMGKLVLAE 356 Query: 1221 L 1223 L Sbjct: 357 L 357
>Q87SS8:LEU3_VIBPA 3-isopropylmalate dehydrogenase - Vibrio parahaemolyticus| Length = 363 Score = 114 bits (286), Expect = 8e-25 Identities = 108/357 (30%), Positives = 167/357 (46%), Gaps = 34/357 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFETYE-------VHGDMPSVPTEVIESIR 395 + ++PGDGIGP V +V++A+ + FE E + +P + + Sbjct: 8 IAVLPGDGIGPEVMAQAHKVLDAIEQKHGISFEREEHDVGGIAIDNHGCPLPESTVTACE 67 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + + L LRK L+ +L GL P R + Sbjct: 68 ESDAVLFGSVGGPKWEHLPPNDQPERGALLPLRKHFQLFCNLRPAQIHAGLEAFSPLRAD 127 Query: 543 ----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 DI V+RE T G Y G E E +V ++ ERIAK AFE A L Sbjct: 128 ISGRGFDIVVVRELTGGIYFGQPKGREGEGANEKAFDTEVYHRYEIERIAKIAFESARLR 187 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 RKKV ++ KAN+++ + L+ E E+A YP ++ + + +DN MQL+ P QFDVM+ Sbjct: 188 -RKKVCSIDKANVLQ-SSILWREVVEEIAKDYPDVELSHMYIDNATMQLIKDPAQFDVML 245 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE-QGASAGNVGNDKILQQKKANPV 1052 N++G+++S+ A I + ++E G SA ++ I ANPV Sbjct: 246 CSNIFGDIISDECAMITGSMGMLPSASLNESKFGLYEPAGGSAPDIAGKNI-----ANPV 300 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS---TTQEVTDAV 1211 A LS+A+MLR+ L + A +ESAV ++ G+ T DL TT E+ D + Sbjct: 301 AQILSAALMLRYSLGEEAAAQDIESAVSKALSAGEL-TADLASDKPALTTSEMGDKI 356
>Q5HMF8:LEU3_STAEQ 3-isopropylmalate dehydrogenase - Staphylococcus epidermidis (strain| ATCC 35984 / RP62A) Length = 347 Score = 114 bits (286), Expect = 8e-25 Identities = 104/343 (30%), Positives = 161/343 (46%), Gaps = 24/343 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVM----EAMHAPVCFETYEVHG---DMPSVP--TEVIESIR 395 + +PGDGIGP + +++ E H E++ G D P E ++S + Sbjct: 5 IVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVSIDYYGTPLTNETLQSCK 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGL----PTRH---E 542 L G + P ++ L+LRK L+L+A++ F G P + E Sbjct: 65 NADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLSPLKQDIVE 124 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPG-VVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTA 719 D+ ++RE T G Y G V ++SLK ++ ERI + AF A RKK+T+ Sbjct: 125 GTDLVIVRELTSGIYFGEPSYVKKTEALDSLKYSSQEI-ERIVRIAFNLAN-RRRKKLTS 182 Query: 720 VHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGN 899 V K N++ + L+ + +V YP ++ N ++VD C M L+ +P QFDV+VT NL+G+ Sbjct: 183 VDKENVLS-SSKLWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQPTQFDVIVTENLFGD 241 Query: 900 LVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ--GASAGNVGNDKILQQKKANPVALFLSSA 1073 ++S+ A+ I Q + SA ++ N + KANP + LS A Sbjct: 242 ILSDEASVIPGSLGLSPSASFGQTGTRLYEPIHGSAPDIAN-----EDKANPFGMVLSLA 296 Query: 1074 MMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEV 1199 + LR L A+ LES V I K T DLGG T E+ Sbjct: 297 LCLRESLNQNDAANELESIVYSFIQSNK-TTADLGGQYRTSEI 338
>Q92A27:LEU3_LISIN 3-isopropylmalate dehydrogenase - Listeria innocua| Length = 350 Score = 114 bits (285), Expect = 1e-24 Identities = 107/357 (29%), Positives = 176/357 (49%), Gaps = 29/357 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVH------------GDMPSVPTEVIE 386 +T + GDGIGP + + +++EA+ A T+E+ GD +P E ++ Sbjct: 5 ITSLAGDGIGPEIMASGIKILEAIAAKYN-HTFEIESHPFGGAGIDAAGD--PIPPETLK 61 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGLPTRH----- 539 + + L G + P L LRK L L+A+ + +P T Sbjct: 62 ACQNADAILLGAIGGPKWDNAPKRPEDGLLALRKALGLFAN-IRPIQVPSSITHLSPLKK 120 Query: 540 ---ENVDIAVIRENTEGEYSGL-EHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRK 707 EN D V+RE T G Y G +H V+SL T+ ERI + AFE A N K Sbjct: 121 EIVENTDFVVVRELTGGLYFGEPKHWDDVAAVDSL-TYTRVEIERIIEKAFEIASTRN-K 178 Query: 708 KVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPN 887 KVT+V KAN++ + L+ + EVA+++P I + VD M ++ +P FDV+VT N Sbjct: 179 KVTSVDKANVLA-SSKLWRKIAEEVASRHPDITLEHLYVDAAAMLMIQRPTTFDVIVTEN 237 Query: 888 LYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQ-GASAGNVGNDKILQQKKANPVALF 1061 L+G+++S+ A+ I ++ +++E SA ++ N I ANP+++ Sbjct: 238 LFGDILSDEASVITGSLGMLPSASHAENGPSLYEPIHGSAPDIANQNI-----ANPMSMI 292 Query: 1062 LSSAMMLRHLQFPSF--ADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 S +MMLR F F AD +++A + G + T DLGG ++T + T+ V+ +++ Sbjct: 293 SSVSMMLRQ-SFSLFKEADAIDAATARTMQAG-FLTADLGGNTSTTDFTNEVLKQIE 347
>Q9CJN6:LEU3_PASMU 3-isopropylmalate dehydrogenase - Pasteurella multocida| Length = 359 Score = 113 bits (283), Expect = 2e-24 Identities = 105/357 (29%), Positives = 168/357 (47%), Gaps = 34/357 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE----TYEVHGDM-----PSVPTEVIESIR 395 + ++ GDGIGP + +V++ + F+ T++V G +P ++ Sbjct: 6 IAVLSGDGIGPEIIAEAIKVLDVVQQKYAFKLNYRTFDVGGIAIDNHGTPLPEATLKGCE 65 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+ +L GL P R + Sbjct: 66 ESDAILFGSVGGPKWEHLPPAQQPERGALLPLRKHFALFCNLRPATLYKGLEKFCPLRAD 125 Query: 543 ----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 D+ +RE T G Y G E E +V ++ ERIA+ AFE A + Sbjct: 126 ISAKGFDMVTVRELTGGIYFGQPKGREGEGANEKAFDTEVYHRYEIERIARVAFETA-MK 184 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 K VT+V KAN++ ++ L+ E +VA YP + + I +DN MQL+ +PE FDV++ Sbjct: 185 RSKHVTSVDKANVL-ISSVLWREVVCDVAKDYPEVTLDHIYIDNATMQLIKQPEFFDVLL 243 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQ-DHAVFE-QGASAGNVGNDKILQQKKANPV 1052 N++G+++S+ A I + ++E G SA ++ I ANP+ Sbjct: 244 CSNIFGDIISDECAMITGSMGMLPSASLNEKGFGLYEPAGGSAPDIAGKGI-----ANPI 298 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS---TTQEVTDAV 1211 A LS+AMMLRH A +E+AVK V+AEG +RT DL S +T+++ D + Sbjct: 299 AQILSAAMMLRHSFNLNDAATAIENAVKNVLAEG-HRTADLADESQPLSTKQMGDLI 354
>Q73VI1:LEU3_MYCPA 3-isopropylmalate dehydrogenase - Mycobacterium paratuberculosis| Length = 336 Score = 113 bits (283), Expect = 2e-24 Identities = 103/346 (29%), Positives = 166/346 (47%), Gaps = 19/346 (5%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEV-----HGDMPSVPTEVIESIRRNKV 407 + +I GDGIGP VT +V++A+ V Y++ H +P VI+ +R + Sbjct: 3 LAVIGGDGIGPEVTAEALKVLDAVLPGVDKTEYDLGARRYHATGELLPDSVIDELRAHDA 62 Query: 408 CLKGGLATP-VGGGV--SSLNLQLRKELDLYASLVNCFNLPGLPTR---HENVDIAVIRE 569 L G + P V GV L L+LR ELD + +L PG+ + + ++D V+RE Sbjct: 63 ILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPGRLYPGVSSPLAGNPDIDFVVVRE 122 Query: 570 NTEGEYSGLEHEVVPG----VVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAVHKANI 737 TEG Y+G + G V + T F R+ AFE A RK +T VHK N+ Sbjct: 123 GTEGPYTGTGGAIRVGTPNEVATEVSQNTAFGVRRVVVDAFERAR-RRRKHLTLVHKTNV 181 Query: 738 MKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLVSNVA 917 + A L+ EV YP ++ +D + +V P +FDV+VT NL+G+++++++ Sbjct: 182 LTFAGKLWSRIVAEVGRDYPDVEVAYQHIDAATIFMVTDPGRFDVIVTDNLFGDIITDLS 241 Query: 918 AGIA---XXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSAMMLR 1085 A + + ++FE SA ++ I A+P A +S A++L Sbjct: 242 AAVCGGIGLAASGNIDGTRTNPSMFEPVHGSAPDIAGQGI-----ADPTAAIMSVALLLA 296 Query: 1086 HLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 HL + A R++ AV+ +A TR +TT EV + + A L Sbjct: 297 HLGEDAAATRVDRAVERYLA-----TRGNERPATT-EVGERIAAAL 336
>P29102:LEU3_BRANA 3-isopropylmalate dehydrogenase, chloroplast precursor - Brassica| napus (Rape) Length = 406 Score = 113 bits (283), Expect = 2e-24 Identities = 111/367 (30%), Positives = 173/367 (47%), Gaps = 39/367 (10%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHA----PVCFETYEVHG---DMPSVPT--EVIESIR 395 +TL+PGDGIGP V + V++ + F+ V G D+ VP E + + + Sbjct: 46 ITLLPGDGIGPEVISIAKNVLQQAGSLEGLEFSFQEMPVGGAALDLVGVPLPEETVSAAK 105 Query: 396 RNKVCLKGGLATPVGGGVSSLN----------LQLRKELDLYASLVNCFNLPGLPTRH-- 539 + L G +GG N LQLR L ++A+L LP L Sbjct: 106 ESDAVLLGA----IGGYKWDKNEKHLKPETGLLQLRAGLKVFANLRPATVLPQLVDASTL 161 Query: 540 -----ENVDIAVIRENTEGEYSGLEHEVVPG-----VVESLKVMTKFCSERIAKYAFEYA 689 E VD+ V+RE T G Y G+ + V + +V +RIA+ AFE A Sbjct: 162 KREVAEGVDLMVVRELTGGIYFGVPRGIKTNENGEEVGYNTEVYAAHEIDRIARVAFETA 221 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD 869 R K+ +V KAN++ A L+ +A +YP ++ + + VDN MQLV P+QFD Sbjct: 222 R-KRRGKLCSVDKANVLD-ASILWRRRVTALAAEYPDVELSHMYVDNAAMQLVRDPKQFD 279 Query: 870 VMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQKK 1040 +VT N++G+++S+ A+ I +FE G++ G D K Sbjct: 280 TIVTNNIFGDILSDEASMITGSIGMLPSASLSDSGPGLFEPIHGSAPDIAGQD------K 333 Query: 1041 ANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTD 1205 ANP+A LS+AM+L++ L A R+E AV G + +G +RT D+ T +E+ + Sbjct: 334 ANPLATILSAAMLLKYGLGEEKAAKRIEDAVLGALNKG-FRTGDIYSAGTKLVGCKEMGE 392 Query: 1206 AVIAKLD 1226 V+ +D Sbjct: 393 EVLKSVD 399
>Q8YXA2:LEU3_ANASP 3-isopropylmalate dehydrogenase - Anabaena sp. (strain PCC 7120)| Length = 362 Score = 113 bits (283), Expect = 2e-24 Identities = 107/346 (30%), Positives = 163/346 (47%), Gaps = 36/346 (10%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM--HAPVCFETYE-------VHGDMPSVPTEVIESIR 395 +TL+PGDGIGP + V++ + + F+ E + +P+ +++ R Sbjct: 7 ITLLPGDGIGPEIMAVAVDVLKVVGQQFDIQFDFQEALIGGAAIDATGEPLPSATLDTCR 66 Query: 396 RNKVCLKGGLA-----------TPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRH- 539 + L + P GG L LR L+L+A+L LP L Sbjct: 67 HSDAVLLAAIGGYKWDSLPPHQRPEGG-----LLGLRAGLELFANLRPAQILPQLIDAST 121 Query: 540 ------ENVDIAVIRENTEGEYSGLEHEVVP---GVVESLKVMTKFCSE--RIAKYAFEY 686 E VDI V+RE T G Y G + G + M SE RI + AFE Sbjct: 122 LKREVVEGVDIMVVRELTGGIYFGKPRGIFTTETGEKRGVNTMVYTESEIDRIGRIAFET 181 Query: 687 AYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQF 866 A R K+ +V KAN++ ++ L+ + ++ +YP ++ + + VDN MQLV P+QF Sbjct: 182 AR-KRRGKLCSVDKANVLDVSQ-LWRDRITNLSQEYPDVELSHLYVDNAAMQLVRAPKQF 239 Query: 867 DVMVTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQK 1037 D +VT NL+G+++S+ AA + VFE G++ G D Sbjct: 240 DTIVTGNLFGDILSDAAAMLTGSIGMLPSASLGASGPGVFEPVHGSAPDIAGQD------ 293 Query: 1038 KANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL 1172 KANP+A LS+AMMLR+ L P AD++E AV V+ +G RT D+ Sbjct: 294 KANPLAQVLSAAMMLRYALDQPQAADKIEQAVLQVLEQGD-RTGDI 338
>Q8CNL2:LEU3_STAES 3-isopropylmalate dehydrogenase - Staphylococcus epidermidis (strain| ATCC 12228) Length = 347 Score = 113 bits (282), Expect = 2e-24 Identities = 103/343 (30%), Positives = 161/343 (46%), Gaps = 24/343 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVM----EAMHAPVCFETYEVHG---DMPSVP--TEVIESIR 395 + +PGDGIGP + +++ E H E++ G D P E ++S + Sbjct: 5 IVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVSIDYYGTPLTNETLQSCK 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGL----PTRH---E 542 L G + P ++ L+LRK L+L+A++ F G P + E Sbjct: 65 NADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLSPLKQDIVE 124 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPG-VVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTA 719 D+ ++RE T G Y G V ++SLK ++ ERI + AF A RKK+T+ Sbjct: 125 GTDLVIVRELTSGIYFGEPSYVKKTEALDSLKYSSQEI-ERIVRIAFNLAN-RRRKKLTS 182 Query: 720 VHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGN 899 V K N++ + L+ + +V YP ++ N ++VD C M L+ +P QFDV+VT NL+G+ Sbjct: 183 VDKENVLS-SSKLWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQPTQFDVIVTENLFGD 241 Query: 900 LVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ--GASAGNVGNDKILQQKKANPVALFLSSA 1073 ++S+ A+ I Q + SA ++ N + KANP + LS A Sbjct: 242 ILSDEASVIPGSLGLSPSASFGQTGTRLYEPIHGSAPDIAN-----EDKANPFGMVLSLA 296 Query: 1074 MMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEV 1199 + LR L A+ LES V I K T DLGG T ++ Sbjct: 297 LCLRESLNQNDAANELESIVYSFIQSNK-TTADLGGQYRTSKI 338
>Q3IJS3:LEU3_PSEHT 3-isopropylmalate dehydrogenase - Pseudoalteromonas haloplanktis| (strain TAC 125) Length = 358 Score = 113 bits (282), Expect = 2e-24 Identities = 110/363 (30%), Positives = 169/363 (46%), Gaps = 35/363 (9%) Frame = +3 Query: 240 TVTLIPGDGIGPLVTGAVRQVMEAM-----------HAPVCFETYEVHGDMPSVPTEVIE 386 +V ++ GDGIGP + A QV++A+ H + + HG ++P + Sbjct: 7 SVAVLAGDGIGPEIMAAAEQVLDAVSNKFGFTLNREHHAIGGAAIDKHGK--ALPQSTVT 64 Query: 387 SIRRNKVCLKGGLATPVGGGV--------SSLNLQLRKELDLYASLVNCFNLPGLPTR-- 536 + L G + P + SL L LRK L+ +L LP L T Sbjct: 65 ACENADAILFGAVGGPKWEHLPPDEQPERGSL-LPLRKHFGLFCNLRPAQLLPALSTASP 123 Query: 537 ------HENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCS---ERIAKYAFEYA 689 + DI +RE T G Y G + G ES ++ ERIA++AFE A Sbjct: 124 LRADISEQGFDILCVRELTGGIYFGEKGRSGEGENESAFDTQRYSRKEIERIARFAFEAA 183 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD 869 L + VT+V KAN++ + L+ E EV+ YP ++ + I VDN MQLV +P QFD Sbjct: 184 KLRS-SHVTSVDKANVLA-SSVLWREVVTEVSKDYPEVKLDYIYVDNAAMQLVKQPSQFD 241 Query: 870 VMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE-QGASAGNVGNDKILQQKKA 1043 V++ NL+G+++S+ A I Q ++E G SA ++ + A Sbjct: 242 VLLCDNLFGDILSDECAMITGSMGLLPSASLNQSGFGLYEPAGGSAPDIAGKGV-----A 296 Query: 1044 NPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVI 1214 NP+A LS+A+MLR+ L A +E AV +A G T D+ TT +V A++ Sbjct: 297 NPIAQILSAALMLRYSLGQDEAARTIEKAVAEAVAAG-VGTPDIFPNAGYTTNDVAAAIV 355 Query: 1215 AKL 1223 A++ Sbjct: 356 ARI 358
>Q3M8T9:LEU3_ANAVT 3-isopropylmalate dehydrogenase - Anabaena variabilis (strain ATCC| 29413 / PCC 7937) Length = 362 Score = 113 bits (282), Expect = 2e-24 Identities = 107/346 (30%), Positives = 165/346 (47%), Gaps = 36/346 (10%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM--HAPVCFETYE-------VHGDMPSVPTEVIESIR 395 +TL+PGDGIGP + V++ + + F+ E + +P+ +++ R Sbjct: 7 ITLLPGDGIGPEIMAVAVDVLKVVGQQFDIQFDFQEALIGGAAIDATGEPLPSATLDTCR 66 Query: 396 RNKVCLKGGLA-----------TPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRH- 539 ++ L + P GG L LR L+L+A+L LP L Sbjct: 67 QSDAVLLAAIGGYKWDSLPPHQRPEGG-----LLGLRAGLELFANLRPAQILPQLIDAST 121 Query: 540 ------ENVDIAVIRENTEGEYSGLEHEVVP---GVVESLKVMTKFCSE--RIAKYAFEY 686 E VDI V+RE T G Y G + G + M SE RI + AFE Sbjct: 122 LKREVVEGVDIMVVRELTGGIYFGKPRGIFTTETGEKRGVNTMVYTESEIDRIGRIAFET 181 Query: 687 AYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQF 866 A R K+ +V KAN++ ++ L+ + +++ +YP ++ + + VDN MQLV P+QF Sbjct: 182 AR-KRRGKLCSVDKANVLDVSQ-LWRDRITKLSQEYPDVELSHLYVDNAAMQLVRAPKQF 239 Query: 867 DVMVTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQK 1037 D +VT NL+G+++S+ AA + VFE G++ G D Sbjct: 240 DTIVTGNLFGDILSDAAAMLTGSIGMLPSASLGASGPGVFEPVHGSAPDIAGLD------ 293 Query: 1038 KANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL 1172 KANP+A LS+AMMLR+ L P AD++E AV V+ +G RT D+ Sbjct: 294 KANPLAQVLSAAMMLRYALNQPQAADKIEQAVLQVLEQGD-RTGDI 338
>Q7M886:LEU3_WOLSU 3-isopropylmalate dehydrogenase - Wolinella succinogenes| Length = 358 Score = 112 bits (281), Expect = 3e-24 Identities = 104/334 (31%), Positives = 167/334 (50%), Gaps = 24/334 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFET----YEVHG---DMPSVPT--EVIESIR 395 + +I GDGIGP + ++V++A+ FE Y + G D VP E IE Sbjct: 6 IAIIKGDGIGPEIVDEAKKVLDAISYSHGFELSYHDYLMGGIAVDRAGVPLPDETIEGCL 65 Query: 396 RNKVCLKGGL------ATPVGGGVSSLNLQLRKELDLYASL---VNCFNLPGLPTRHENV 548 R L G + + P S L+LRK L+++A+L V L T E+V Sbjct: 66 RADAVLFGAIGGEKWDSLPRELRPESGLLKLRKSLEIFANLRPTVVYDELIEASTLKESV 125 Query: 549 ----DIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVT 716 DI V+RE G Y G + V + ERIA AF+ A + +K+V Sbjct: 126 IKGVDILVVRELIGGIYFGEPKGREGDKAFNTMVYSVPEIERIAHVAFKAA-MRRQKRVC 184 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 +V KAN++ ++ L+ E+ +A +YP ++ + + +DN MQL+ P+QFDV++T NL+G Sbjct: 185 SVDKANVLDVSQ-LWRETVTRIAKEYPEVELSHMYIDNAAMQLIRNPKQFDVILTGNLFG 243 Query: 897 NLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPVALFLSSA 1073 +++S+ A+ ++ A++E SA ++ I ANP+A S++ Sbjct: 244 DILSDEASMLSGSIGLLPSASIGGKAALYEPIHGSAPDIAGQGI-----ANPIATIASAS 298 Query: 1074 MMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL 1172 MMLRH L AD ++ A+ + EG YRT+D+ Sbjct: 299 MMLRHSLGEVEAADAIDKAIVKTLKEG-YRTKDI 331
>Q7N128:LEU3_PHOLL 3-isopropylmalate dehydrogenase - Photorhabdus luminescens subsp.| laumondii Length = 363 Score = 112 bits (281), Expect = 3e-24 Identities = 103/343 (30%), Positives = 164/343 (47%), Gaps = 31/343 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFET--YEVHGDMP-----SVPTEVIESIR 395 + ++PGDGIGP V ++++A+ +C T Y+V G S+P + + Sbjct: 7 IAVLPGDGIGPEVMAQAYKILDAIRKRFNICITTSEYDVGGIAIDRHGCSLPAKTVAGCE 66 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+++L GL P R++ Sbjct: 67 QADAILFGSVGGPKWEHLPPAEQPERGALLPLRKHFKLFSNLRPARLYAGLEVFCPLRND 126 Query: 543 ----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G E + +V +F ERIA+ AFE A Sbjct: 127 IAAKGFDILCVRELTGGIYFGQPKGREGQGKYERAFDTEVYHRFEIERIARIAFESARKR 186 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 + K VT++ KAN+++ + L+ E E+A YP ++ N + +DN MQL+ P QFDVM+ Sbjct: 187 SNK-VTSIDKANVLQ-SSVLWREVVTEIAKAYPDVEINHMYIDNATMQLIKDPSQFDVML 244 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQ-DHAVFE-QGASAGNVGNDKILQQKKANPV 1052 N++G+++S+ A I + ++E G SA ++ I ANP+ Sbjct: 245 CSNIFGDILSDECAMITGSMGMLPSASLNEKGFGLYEPAGGSAPDIAGKGI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGG 1178 A LS+A++LR+ L A+ +E AV + +G YRT DL G Sbjct: 300 AQILSAALLLRYSLGHNDAANAIEQAVNYALEQG-YRTTDLAG 341
>Q606F4:LEU3_METCA 3-isopropylmalate dehydrogenase - Methylococcus capsulatus| Length = 360 Score = 112 bits (281), Expect = 3e-24 Identities = 109/363 (30%), Positives = 169/363 (46%), Gaps = 36/363 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----------HAPVCFETYEVHGDMPSVPTEVIES 389 + ++PGDGIGP + +V++ + HA + Y+ HG P E +E Sbjct: 5 IAVLPGDGIGPEIVAEALKVLDCLRSDFGLAVETEHALIGGAAYDAHGT--PFPKETLEL 62 Query: 390 IRRNKVCLKGGLATPVGGGVS-SLN-----LQLRKELDLYASLVNCFNLPGL-------P 530 R L G + P + SL L LR EL+L+++L P L P Sbjct: 63 CRAADSILLGAVGGPKWEPLDYSLRPERGLLGLRSELELFSNLRPAVLYPQLVSASTLKP 122 Query: 531 TRHENVDIAVIRENTEGEYSGLEHEV---VPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE T G Y G G E + SE RIA AF+ A Sbjct: 123 EVVAGLDIMIVRELTGGIYFGKPRGRRINEDGEREGYNTLVYSESEIRRIAHSAFQIARK 182 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 NR+ + ++ KAN+++ + L+ E EV YP + + + VDN MQLV P+QFDVM Sbjct: 183 RNRR-LCSIDKANVLECTE-LWREVVIEVGKDYPDVALSHMYVDNAAMQLVRNPKQFDVM 240 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQ-GASAGNVGNDKILQQKKANP 1049 +T N++G+++S+ AA + + ++E SA ++ I ANP Sbjct: 241 LTDNMFGDILSDCAAMLTGSIGMLPSASLAESGKGMYEPIHGSAPDIAGRGI-----ANP 295 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVI 1214 +A LS AMMLR+ A+R+ AV+ + +G +RT D+ T T + DA++ Sbjct: 296 IATILSLAMMLRYSFDDAVSAERIGKAVQTALDQG-FRTADIASEGTVEVGTAAMGDAIV 354 Query: 1215 AKL 1223 A L Sbjct: 355 AAL 357
>P24404:LEU3_AGRT5 3-isopropylmalate dehydrogenase - Agrobacterium tumefaciens (strain| C58 / ATCC 33970) Length = 370 Score = 112 bits (281), Expect = 3e-24 Identities = 112/373 (30%), Positives = 177/373 (47%), Gaps = 45/373 (12%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAP-----------VCFETYEVHGDMPSVPTEVI 383 R++ L+PGDGIGP VR+++E M++ V Y+ HG ++ + Sbjct: 4 RSLFLLPGDGIGPEAMTEVRKLIEYMNSAHNAGFTVSEGLVGGSAYDAHG--VAISDADM 61 Query: 384 ESIRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL------ 527 E L G + P GV + L+LRK+L+L+A+L P L Sbjct: 62 EKALAADAILFGAVGGPKWDGVPYEHRPEAGLLRLRKDLELFANLRPAICYPALAAASSL 121 Query: 528 -PTRHENVDIAVIRENTEGEYSGLEHEVVP-------GVVESLKVMTKFCSERIAKYAFE 683 P E +DI ++RE T G Y G +++ G+ ++ F ERIA AFE Sbjct: 122 KPELVEGLDILIVRELTGGVYFGEPKQIIDLGNGQKRGI--DTQIYDTFEIERIASVAFE 179 Query: 684 YAYLNNRKKVTAVHKANIMKLADGLFLESCREV-ATKYPGIQYNEIIVDNCCMQLVAKPE 860 A + + V ++ K N+MK + L+ + E A KY +Q ++ D MQLV KP+ Sbjct: 180 LARSRDNR-VCSMEKRNVMK-SGVLWNQVVTETHAAKYKDVQLEHMLADAGGMQLVRKPK 237 Query: 861 QFDVMVTPNLYGNLVSNVAAGIA-------XXXXXXXXXXXXQDHAVFEQ-GASAGNVGN 1016 QFDV+VT NL+G+++S+VAA + + A++E SA ++ Sbjct: 238 QFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGAPDAKTGKRKAMYEPVHGSAPDIAG 297 Query: 1017 DKILQQKKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST-- 1187 I ANP+A+ S AM LR+ A +LE+A+ V+ +G RT D+ Sbjct: 298 KSI-----ANPIAMIASFAMCLRYSFNMVDEATKLEAAIANVLDKG-IRTADIMADGCRQ 351 Query: 1188 --TQEVTDAVIAK 1220 T ++ DAV+A+ Sbjct: 352 VGTSDMGDAVLAE 364
>Q71Y34:LEU3_LISMF 3-isopropylmalate dehydrogenase - Listeria monocytogenes serotype 4b| (strain F2365) Length = 350 Score = 112 bits (280), Expect = 4e-24 Identities = 106/355 (29%), Positives = 174/355 (49%), Gaps = 27/355 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGD----------MPSVPTEVIESI 392 +T + GDGIGP + + QV+EA+ A T+E+ +P+ +++ Sbjct: 5 ITSLAGDGIGPEIMTSGLQVLEAV-AKKYNHTFEIESHPFGGAGIDVAQDPIPSSTLKAC 63 Query: 393 RRNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGLPTRH------- 539 R L G + P L LRK L L+A+ + +P T Sbjct: 64 RDADAILLGAIGGPKWDNAPKRPEDGLLALRKALGLFAN-IRPIQVPSSITHLSPLKKEI 122 Query: 540 -ENVDIAVIRENTEGEYSGL-EHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKV 713 EN D V+RE T G Y G ++ V+SL T+ ERI + AFE A N KKV Sbjct: 123 VENTDFVVVRELTGGLYFGEPKYWDNEAAVDSL-TYTRAEIERIIEKAFEIAATRN-KKV 180 Query: 714 TAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 893 T+V KAN++ + L+ + EVA+++P I + VD M ++ +P FDV+VT NL+ Sbjct: 181 TSVDKANVLA-SSKLWRKIADEVASRHPDITLEHLYVDAAAMLMIQRPTTFDVIVTENLF 239 Query: 894 GNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQ-GASAGNVGNDKILQQKKANPVALFLS 1067 G+++S+ A+ I ++ +++E SA ++ N I ANP+++ S Sbjct: 240 GDILSDEASVITGSLGMLPSASHAENGPSLYEPIHGSAPDIANQNI-----ANPMSMISS 294 Query: 1068 SAMMLRHLQFPSF--ADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 +MMLR F F AD +++A + G + T DLGG ++T + T+ V+ +++ Sbjct: 295 VSMMLRQ-SFSLFEEADAIDAATARTMQAG-FLTADLGGNTSTTDFTNEVLKQIE 347
>Q81G11:LEU3_BACCR 3-isopropylmalate dehydrogenase - Bacillus cereus (strain ATCC 14579| / DSM 31) Length = 354 Score = 112 bits (280), Expect = 4e-24 Identities = 101/352 (28%), Positives = 163/352 (46%), Gaps = 22/352 (6%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVM---EAMHAPVCFETYEVHGDMP------SVPTEVIES 389 + + + GDG+GP V + ++V+ E ++ E G + +P + + Sbjct: 3 KRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEYFGGVAIDLTGQPLPQRTLAA 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASL----VNCFNLPGLPTRH-E 542 + L G + P L LRK L ++A++ V P ++ + Sbjct: 63 CLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKNAD 122 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 +D V+RE T G Y E V + ERI YAF+ A +KKVT++ Sbjct: 123 EIDFVVVRELTGGIYFSYPKERTEEVATDTLTYHRHEIERIVSYAFQLAN-KRKKKVTSI 181 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 KAN+++ + L+ EVA +YP ++ I+VD M+L+ P +FDV+VT NL+G++ Sbjct: 182 DKANVLE-SSKLWRTVTEEVALRYPNVEVEHILVDAAAMELIRNPGRFDVIVTENLFGDI 240 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAG---NVGNDKILQQKKANPVALFLSSA 1073 +S+ A+ +A HA E+G S + I + KANP+A+ S A Sbjct: 241 LSDEASVLA----GSLGMLPSASHA--EKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVA 294 Query: 1074 MML-RHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 MML + +E AV V+ GK T D+GGT TT T AVI +++ Sbjct: 295 MMLGQSFGLTREGYAIEEAVSAVLKSGKC-TADIGGTETTTSFTKAVIQEME 345
>Q5P1J6:LEU3_AZOSE 3-isopropylmalate dehydrogenase - Azoarcus sp. (strain EbN1)| (Aromatoleum aromaticum (strain EbN1)) Length = 350 Score = 112 bits (280), Expect = 4e-24 Identities = 108/356 (30%), Positives = 170/356 (47%), Gaps = 29/356 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSV-----PTEVIESIRRNKV 407 + ++PGDGIGP +T +V+EA+ E + G P + R Sbjct: 3 ICILPGDGIGPEITAEAVRVIEALDLKFEMEEALLGGAAVDATGDPYPEATRKLAREADA 62 Query: 408 CLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------PTRHENV 548 L G + P + L +RK+L L+A+L P L P + Sbjct: 63 VLLGAVGGPKWDTLPREQRPERGLLGIRKDLGLFANLRPAILYPELANASSLKPEVVAGL 122 Query: 549 DIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSE----RIAKYAFEYAYLNNRKKVT 716 DI ++RE T Y G + E T SE RI + AFE A NR+ + Sbjct: 123 DILIVRELTGDIYFGQPRGLEVRDGERFGFNTMHYSESEIRRIGRVAFEAARKRNRR-LC 181 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 +V K N+++ L+ + E+A +YP ++ + ++VDN MQLV P+QFDVMVT N++G Sbjct: 182 SVDKMNVLETTQ-LWRDVMIELAAEYPDVELSHMLVDNAAMQLVRAPKQFDVMVTGNMFG 240 Query: 897 NLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQG-ASAGNVGNDKILQQKKANPVALFLSS 1070 +++S+ A+ + ++ ++E SA ++ I ANP+A LS Sbjct: 241 DILSDEASMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGQGI-----ANPLATILSV 295 Query: 1071 AMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVIAKL 1223 AMMLR+ + A R+E+AVK V+A+G RT D+ T T+++ DAV+A L Sbjct: 296 AMMLRYTFNQENGALRIENAVKKVLAQG-LRTGDIFEPGTTKVGTKQMGDAVLAAL 350
>Q6FEV6:LEU3_ACIAD 3-isopropylmalate dehydrogenase - Acinetobacter sp. (strain ADP1)| Length = 359 Score = 112 bits (280), Expect = 4e-24 Identities = 111/367 (30%), Positives = 175/367 (47%), Gaps = 38/367 (10%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAM-----------HAPVCFETYEVHGDMPSVPTEVI 383 + + ++ GDGIGP + GA QV+ + H + + HG+ P Sbjct: 3 KQILILAGDGIGPEIVGAAEQVLTKVNEKFELGLTWEHGLLGGSAIDAHGE--PYPAVTS 60 Query: 384 ESIRRNKVCLKGGLATPVGGGVS-SLN-----LQLRKELDLYASLVNCFNLPGL------ 527 E ++ L G + P + S+ L++R EL+L+A+L P L Sbjct: 61 EQAKKADAILLGAVGGPKWDTIERSIRPERGLLKIRSELNLFANLRPALLYPQLADASSL 120 Query: 528 -PTRHENVDIAVIRENTEGEYSG-------LEHEVVPGVVESLKVMTKFCSERIAKYAFE 683 P +DI ++RE T G Y G LE+ G + V ++ +RIAK AFE Sbjct: 121 KPEIVAGLDILIVRELTGGIYFGQPRGIRELENGEKQGY--NTDVYSESEIKRIAKVAFE 178 Query: 684 YAYLNNRKKVTAVHKANIMKLADGLFLESCREVA-TKYPGIQYNEIIVDNCCMQLVAKPE 860 A L KV +V KAN++++ + L+ ++ E+ +YP IQ + + VDN MQLV P+ Sbjct: 179 LAALRG-SKVCSVDKANVLEVTE-LWKQTVTELQQAQYPNIQLSHMYVDNAAMQLVRAPK 236 Query: 861 QFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQGASAGNVGNDKILQQK 1037 QFDV+VT NL+G+++S+ AA + ++ ++E + I Q Sbjct: 237 QFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSA----PDIAGQN 292 Query: 1038 KANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVT 1202 ANP+A LS AMMLR+ + + A +E AV V+ +G RT D+ T E+ Sbjct: 293 VANPLATILSVAMMLRYTFREEAAAKAIEDAVGQVLDQG-LRTADIMSEGMQRVGTVEMG 351 Query: 1203 DAVIAKL 1223 AV+A L Sbjct: 352 QAVVAAL 358
>Q5E857:LEU3_VIBF1 3-isopropylmalate dehydrogenase - Vibrio fischeri (strain ATCC 700601| / ES114) Length = 363 Score = 112 bits (279), Expect = 5e-24 Identities = 105/357 (29%), Positives = 162/357 (45%), Gaps = 34/357 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSV---------PTEVIESIR 395 + ++PGDGIGP V +V++A+ D+ + P ++ Sbjct: 8 IAVLPGDGIGPEVMEQAHKVLDAIEKKHAISFSREQHDVGGIAIDNHGCPLPESTVKGCE 67 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + + L LRK L+ +L GL P R + Sbjct: 68 ESDAVLFGSVGGPKWEHLPPNDQPERGALLPLRKHFQLFCNLRPAQIHKGLENFSPLRAD 127 Query: 543 ----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 DI V+RE T G Y G E E ++ ++ ERIAK AFE A L Sbjct: 128 ISERGFDIVVVRELTGGIYFGQPKGREGEGPQEKAYDTEIYHRYEIERIAKIAFESARLR 187 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 N K V ++ KAN+++ + L+ E EVA YP + N + +DN MQL+ P QFDVM+ Sbjct: 188 N-KNVYSIDKANVLQ-SSILWREVVEEVAKGYPDVTLNHMYIDNATMQLIKDPSQFDVML 245 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFE-QGASAGNVGNDKILQQKKANPV 1052 N++G+++S+ A I + + ++E G SA ++ I ANPV Sbjct: 246 CSNIFGDIISDECAMITGSMGMLPSASLNESNFGLYEPAGGSAPDIAGKNI-----ANPV 300 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS---TTQEVTDAV 1211 A LS+A+MLR+ L A +E+AV ++ G+ T DL G TT + D + Sbjct: 301 AQILSAALMLRYSLGEEEAAQSIEAAVSKALSAGEL-TADLAGDKPALTTSAMGDKI 356
>Q6LV25:LEU3_PHOPR 3-isopropylmalate dehydrogenase - Photobacterium profundum| (Photobacterium sp. (strain SS9)) Length = 362 Score = 112 bits (279), Expect = 5e-24 Identities = 106/359 (29%), Positives = 163/359 (45%), Gaps = 34/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSV---------PTEVIESIR 395 + ++PGDGIGP V +V++A+ F D+ + P ++ Sbjct: 7 IAVLPGDGIGPEVMLQAHKVLDAVEEKFGFTLERSEHDVGGIAIDNHGCPLPESTMKGCE 66 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P ++ + L LRK L+ +L GL P R + Sbjct: 67 ESDAILFGSVGGPKWEHLAPNDQPERGALLPLRKHFQLFCNLRPAQIHSGLEGFSPLRAD 126 Query: 543 ----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 DI V+RE T G Y G E E ++ ++ ERIA+ AFE A L Sbjct: 127 ISERGFDIVVVRELTGGIYFGQPKGREGEGPQEKAYDTEIYHRYEIERIARIAFESAMLR 186 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 K V ++ KAN+++ + L+ E EVA YP + N + +DN MQL+ P QFDVM+ Sbjct: 187 E-KNVYSIDKANVLQ-SSILWREVVEEVAKDYPEVTLNHMYIDNATMQLIKDPSQFDVML 244 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE-QGASAGNVGNDKILQQKKANPV 1052 N++G+++S+ A I Q+ ++E G SA ++ I ANPV Sbjct: 245 CSNIFGDIISDECAMITGSMGMLPSASLNQEKFGMYEPAGGSAPDIAGKNI-----ANPV 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS---TTQEVTDAVIA 1217 A LS+A+MLR+ L A +E AV + G+ T DL G +T E+ D + A Sbjct: 300 AQILSAALMLRYSLDEEKAARAIEQAVSQALEAGEL-TADLAGKGAALSTSEMGDKIAA 357
>Q8EN68:LEU3_OCEIH 3-isopropylmalate dehydrogenase - Oceanobacillus iheyensis| Length = 366 Score = 112 bits (279), Expect = 5e-24 Identities = 106/354 (29%), Positives = 176/354 (49%), Gaps = 30/354 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPV----CFETYEVHGDM-----PSVPTEVIESIR 395 + L+PGDGIG + + +QV+ A+ + FE + + G +P + +++ Sbjct: 5 IILLPGDGIGREIIDSAKQVLTAIASEYNHRFTFEEHAIGGSAIDEYGTPLPDKTVDACS 64 Query: 396 RNKVCLKGGLATPV-GGGVSSLN-----LQLRKELDLYASLVNCFNLPGL----PTRHEN 545 + L G + P S L L +RK+L L+A+L + L P + E Sbjct: 65 KADAILLGAVGGPKWDANPSHLRPEKGLLGIRKQLGLFANLRPVKTISSLLYASPLKEEI 124 Query: 546 V---DIAVIRENTEGEYSGLEHE-VVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKV 713 V D+ +IRE T G Y G E GVV++L+ + ERI + FE A + +K + Sbjct: 125 VSQADMLIIRELTGGIYFGTPSERTTNGVVDTLQYSREEI-ERIVERGFEAARIR-KKHL 182 Query: 714 TAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 893 T+V KAN+++ + L+ E E + YP + N ++VD M+LV +P FDV+VT NL+ Sbjct: 183 TSVDKANVLE-SSKLWREIVEEKSKDYPDVAVNHLLVDAAAMKLVTQPSFFDVIVTENLF 241 Query: 894 GNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQ-GASAGNVGNDKILQQKKANPVALFLS 1067 G+++S+ A+ + D ++E SA ++ I ANP+A+ LS Sbjct: 242 GDILSDEASVLTGSLGMLPSASLRADGLGLYEPVHGSAPDIAGKGI-----ANPLAMILS 296 Query: 1068 SAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL---GGTST-TQEVTDAVI 1214 +A+ML H A +E AV + +G + T D+ GG T+++TDAV+ Sbjct: 297 AALMLEHSFGLVDEAKEIERAVNDCLLQG-FHTADIHIPGGVQVGTKQMTDAVL 349
>Q2SJD6:LEU3_HAHCH 3-isopropylmalate dehydrogenase - Hahella chejuensis (strain KCTC| 2396) Length = 360 Score = 112 bits (279), Expect = 5e-24 Identities = 109/357 (30%), Positives = 165/357 (46%), Gaps = 32/357 (8%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHG-------DMPSVP--TEVIES 389 + V ++PGDGIGP + R V++ ++ G D VP E + + Sbjct: 3 KQVLILPGDGIGPEIVAQARNVLDVVNNKFSLGLTFTEGLVGGAAIDTTGVPFPEETLAT 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------P 530 L G + P + L LR L+L+A+L P L P Sbjct: 63 AEAADAILLGAVGGPKWDKLDMAIRPEKGLLGLRSGLELFANLRPAILYPQLAEASSLRP 122 Query: 531 TRHENVDIAVIRENTEGEYSGLEHEVVP---GVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE T G Y G V G E SE RI + AFE A Sbjct: 123 EVVAGLDILIVRELTGGIYFGKPRGVRTLENGEREGFNTYVYSESEIRRIGRVAFEAAQK 182 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 N K++ +V KAN++++ L+ E E+A +YP ++ + + VDN MQLV P+QFDV+ Sbjct: 183 RN-KRLCSVDKANVLEVTV-LWREVMDELAKEYPDVELSHMYVDNAAMQLVRAPKQFDVI 240 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPVA 1055 VT N++G+++S+ AA + +A + + I Q ANP+A Sbjct: 241 VTGNMFGDILSDEAAMLTGSIGMLPSASL---NAAGKGMYEPCHGSAPDIAGQNMANPLA 297 Query: 1056 LFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTS----TTQEVTDAV 1211 LS+AMMLR+ L A +E AV V+ +G RTRD+ G+S +TQ + +AV Sbjct: 298 TILSAAMMLRYSLAAEDAAAAIEQAVSDVLDQG-LRTRDIAGSSGESVSTQAMGEAV 353
>Q7VY73:LEU3_BORPE 3-isopropylmalate dehydrogenase - Bordetella pertussis| Length = 358 Score = 112 bits (279), Expect = 5e-24 Identities = 113/360 (31%), Positives = 169/360 (46%), Gaps = 33/360 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM-----PSVPTEVIESIRRNKV 407 + ++PGDGIGP + +V++A+ P+ V G +P +E + + Sbjct: 5 IAVLPGDGIGPEIVEQAERVLKALDLPLELRQAPVGGAAFDQFEHPLPPATLELAQGSHA 64 Query: 408 CLKGGLAT------PVGGGVSSLNLQLRKELDLYASLVNCFNLPGL-------PTRHENV 548 L G + P L LRK L L+A+L P L P + Sbjct: 65 VLFGAVGDWKYDTLPREFRPEQAILGLRKALGLFANLRPAILYPELASASSLKPEIVSGL 124 Query: 549 DIAVIRENTEGEYSGLEHEV-------VPGVVESLKVMTKFCSE--RIAKYAFEYAYLNN 701 DI +IRE T Y G V G E M SE RIA+ FE A N Sbjct: 125 DILIIRELTGDIYFGTPRGVRTAADGAFAGEREGYDTMRYAESEVRRIARIGFESARKRN 184 Query: 702 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 KK+ +V KAN+++ + + + EV+ Y ++ + + VDN MQLV P QFDV+VT Sbjct: 185 -KKLCSVDKANVLETSQ-FWRDLVIEVSRDYLDVELSHMYVDNAAMQLVRNPRQFDVIVT 242 Query: 882 PNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGN-DKILQQKKANPVAL 1058 NL+G+++S+ AA + QG + G+ I Q ANP+A Sbjct: 243 GNLFGDILSDEAAMLTGSIGMLPSASLN----AAGQGLYEPSHGSAPDIAGQGIANPLAT 298 Query: 1059 FLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTS--TTQEVTDAVIAKL 1223 LS+AM+LR+ L ADR+E+AV+ V+A+G RT D+ GT+ +T ++ DAV+ L Sbjct: 299 ILSAAMLLRYSLNLAPQADRVEAAVRKVLADG-LRTADIHEAGTTKVSTSQMGDAVLKAL 357
>P59029:LEU3_SYNEL 3-isopropylmalate dehydrogenase - Synechococcus elongatus| (Thermosynechococcus elongatus) Length = 361 Score = 111 bits (278), Expect = 7e-24 Identities = 103/344 (29%), Positives = 161/344 (46%), Gaps = 34/344 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM---------HAPVCFETYEVHGDMPSVPTEVIESIR 395 + ++ GDGIGP +T V+ A+ P + +P + + R Sbjct: 7 IAVLAGDGIGPEITAVALDVLRAIAPRFGLDFDFVPALVGGCAIDAVGEPLPAATLATCR 66 Query: 396 RNKVCLKGGLATPVGGGVSSLNLQLRKE---------LDLYASLVNCFNLPGL------- 527 ++ L LA G SL LR E L L+A+L P L Sbjct: 67 QSDAVL---LAAIGGTQWDSLPRHLRPETGLLALRSGLGLFANLRPAKIFPQLLHASSLK 123 Query: 528 PTRHENVDIAVIRENTEGEYSGLEHEVVP---GVVESLKVMTKFCSE--RIAKYAFEYAY 692 P VD+ V+RE T G Y G + G + M +E RI + AFE A Sbjct: 124 PEVIAGVDLMVVRELTGGIYFGQPRGIFTTETGEQRGVNTMAYTATEIDRIGRVAFETAR 183 Query: 693 LNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDV 872 + K+ +V KAN+++++ L+ + ++ +YP ++ + VDN MQLV P+QFD Sbjct: 184 -KRQGKLCSVDKANVLEVSQ-LWRDRLTALSAEYPDVELTHLYVDNAAMQLVRAPKQFDT 241 Query: 873 MVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQKKA 1043 +VT NL+G+++S++AA + + A+FE G++ G D KA Sbjct: 242 IVTSNLFGDILSDIAAMLTGSIGMLPSASLGESGPALFEPVHGSAPDIAGQD------KA 295 Query: 1044 NPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL 1172 NP+A+ LS+AMMLR+ L P+ A +E A+ V+ +G YRT DL Sbjct: 296 NPLAMVLSAAMMLRYGLNQPAAAQAIEEAITAVLDQG-YRTGDL 338
>Q1MA50:LEU3_RHIL3 3-isopropylmalate dehydrogenase - Rhizobium leguminosarum bv. viciae| (strain 3841) Length = 370 Score = 111 bits (278), Expect = 7e-24 Identities = 116/377 (30%), Positives = 175/377 (46%), Gaps = 49/377 (12%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVM----EAMHAPVCFE-------TYEVHGDMPSVPTEVI 383 R + L+PGDGIGP G VR+++ EAM+A + Y+ HG S ++ Sbjct: 4 RNLFLLPGDGIGPEAMGEVRKIIAYMNEAMNAGFVTDEGLVGGCAYDAHGAAIS-EADMQ 62 Query: 384 ESIRRNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGL------ 527 +++ + V L G + P V + L+LRK+L L+A+L P L Sbjct: 63 KALAADAV-LFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALAAASSL 121 Query: 528 -PTRHENVDIAVIRENTEGEYSGLEHEVVP-------GVVESLKVMTKFCSERIAKYAFE 683 P E +DI +IRE T G Y G E++ G+ +V + ERIA AFE Sbjct: 122 KPELVEGLDILIIRELTGGVYFGEPKEIIDLGNGQKRGI--DTQVYDTYEIERIAGVAFE 179 Query: 684 YAYLNNRKKVTAVHKANIMKLADGLFLESCREV-ATKYPGIQYNEIIVDNCCMQLVAKPE 860 A + +V ++ K N+MK + L+ + E KY +Q ++ D MQLV +P+ Sbjct: 180 MAR-TRQNRVCSMEKRNVMK-SGVLWNQVVTETHKAKYSDVQLEHMLADAGGMQLVRQPK 237 Query: 861 QFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKK 1040 QFDV+VT NL+G+++S+VAA + GA G G K L + Sbjct: 238 QFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSA---------SLGAPDGKTGKRKALYEPV 288 Query: 1041 ------------ANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGT 1181 ANP+A+ S AM LR+ AD LE A+ V+ +G RT D+ Sbjct: 289 HGSAPDIAGKGIANPIAMIASFAMCLRYSFNLVKEADDLEKAIANVLDKG-IRTGDIMAD 347 Query: 1182 STTQ----EVTDAVIAK 1220 Q E+ DA++A+ Sbjct: 348 GARQVGTVEMGDAILAE 364
>Q47HR1:LEU31_DECAR 3-isopropylmalate dehydrogenase 1 - Dechloromonas aromatica (strain| RCB) Length = 350 Score = 111 bits (278), Expect = 7e-24 Identities = 106/356 (29%), Positives = 170/356 (47%), Gaps = 29/356 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSV-----PTEVIESIRRNKV 407 + ++PGDGIGP +T +V+ ++ E + G P + R Sbjct: 3 ICVLPGDGIGPEITAQAVRVLNSLDLKFEMEEALLGGGAVDATGNPYPEATQKLARAADA 62 Query: 408 CLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------PTRHENV 548 L G + P + L +RK+L+L+A+L P L P + Sbjct: 63 VLLGAVGGPKWDSLPREQRPERGLLGIRKDLNLFANLRPAILYPELANASTLKPEVVAGL 122 Query: 549 DIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSE----RIAKYAFEYAYLNNRKKVT 716 DI +IRE T Y G V E + T SE RI AF+ A + K++ Sbjct: 123 DILIIRELTGDIYFGQPRGVREENGERVGFNTMVYSESEIRRIGHVAFQAAQKRD-KRLC 181 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 +V K N+++ L+ + E++ YP ++ + ++VDN MQLV P+QFDVMVT N++G Sbjct: 182 SVDKMNVLECTQ-LWRDVMIEISRDYPDVELSHMLVDNAAMQLVKAPKQFDVMVTGNMFG 240 Query: 897 NLVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQG-ASAGNVGNDKILQQKKANPVALFLSS 1070 +++S+ A+ + ++ ++E SA ++ + ANP+A LS+ Sbjct: 241 DILSDEASMLTGSIGMLPSASLDDKNKGLYEPSHGSAPDIAGKGV-----ANPLATILSA 295 Query: 1071 AMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVIAKL 1223 AMMLR+ A R+E+AVK V+A+G YRT D+ T T+E+ DAV+A L Sbjct: 296 AMMLRYTFGLEEQALRVENAVKKVLAQG-YRTGDIYERGTNKVGTREMGDAVLAAL 350
>Q3IZJ3:LEU3_RHOS4 3-isopropylmalate dehydrogenase - Rhodobacter sphaeroides (strain| ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) Length = 369 Score = 111 bits (277), Expect = 9e-24 Identities = 116/372 (31%), Positives = 179/372 (48%), Gaps = 43/372 (11%) Frame = +3 Query: 240 TVTLIPGDGIGPLVTGAVRQVM-----------EAMHAPVCFETYEVHGDMPSVPTEVIE 386 ++ ++ GDGIGP V V++++ + V Y+ HG + E + Sbjct: 5 SLLILAGDGIGPEVMAEVKRIIGWFGEKRGVSFDVSEDLVGGAAYDAHGT--PLADETMA 62 Query: 387 SIRRNKVCLKGGLATPVGGGVS-SLN-----LQLRKELDLYASL--VNCFN-LPGLPTRH 539 + L G + P + S+ L+LRKE+DLYA+L CF+ L + Sbjct: 63 RAQEVDAVLLGAVGGPKYDVLDFSVKPERGLLRLRKEMDLYANLRPAQCFDALADFSSLK 122 Query: 540 ENV----DIAVIRENTEGEYSGLEHEVVPGV------VESLKVMTKFCSERIAKYAFEYA 689 ++ DI ++RE T G Y G + P V + + T+ R+A+ AFE A Sbjct: 123 RDIVAGLDIMIVRELTSGVYFGEPRGIFPDNEGGRFGVNTQRYTTEEI-RRVARSAFELA 181 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVA-TKYPGIQYNEIIVDNCCMQLVAKPEQF 866 N + V ++ KAN+M+ + L+ E + V +YP ++ + + DN MQLV P QF Sbjct: 182 RRRNNR-VCSMEKANVME-SGILWREEVQWVHDNEYPDVELSHMYADNGAMQLVRWPRQF 239 Query: 867 DVMVTPNLYGNLVSNVAA------GIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKIL 1028 DV+VT NL+G+++S+ AA G+ + A++E + I Sbjct: 240 DVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAPMANGRPKALYEPVHGSA----PDIA 295 Query: 1029 QQKKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL----GGTS-TT 1190 Q KANP+A LS AM LR+ A RLE AV+ V+A+G RT DL GGT +T Sbjct: 296 GQGKANPIACILSFAMALRYSFDMGEEATRLEKAVETVLADG-VRTADLMGPEGGTPVST 354 Query: 1191 QEVTDAVIAKLD 1226 + DAV+A LD Sbjct: 355 SGMGDAVLAALD 366
>Q63DX7:LEU3_BACCZ 3-isopropylmalate dehydrogenase - Bacillus cereus (strain ZK / E33L)| Length = 354 Score = 111 bits (277), Expect = 9e-24 Identities = 100/353 (28%), Positives = 162/353 (45%), Gaps = 23/353 (6%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVC--FETYEVHGDMPSV-------PTEVIES 389 + + + GDG+GP V + ++V+ + F + H ++ P + + Sbjct: 3 KRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAA 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASL------VNCFNLPGLPTRH 539 + L G + P G L LRK L ++A++ +L L Sbjct: 63 CLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESETAHLSPLKKAD 122 Query: 540 ENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTA 719 E +D V+RE T G Y E V + ERI YAF+ A +KKVT+ Sbjct: 123 E-IDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSYAFQLAS-KRKKKVTS 180 Query: 720 VHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGN 899 + KAN+++ + L+ EVA +YP ++ I+VD M+L+ P +FDV+VT NL+G+ Sbjct: 181 IDKANVLE-SSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFGD 239 Query: 900 LVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAG---NVGNDKILQQKKANPVALFLSS 1070 ++S+ A+ +A HA E+G S + I + KANP+A+ S Sbjct: 240 ILSDEASVLA----GSLGMLPSASHA--EKGPSLYEPIHGSAPDIAGKNKANPIAMMRSV 293 Query: 1071 AMML-RHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 AMML + +E A+ V+ GK T D+GGT TT T AV+ +++ Sbjct: 294 AMMLGQSFGLTREGCAIEEAISAVLKSGKC-TEDIGGTETTTSFTKAVMQEME 345
>Q88LE5:LEU3_PSEPK 3-isopropylmalate dehydrogenase - Pseudomonas putida (strain KT2440)| Length = 360 Score = 110 bits (275), Expect = 2e-23 Identities = 108/363 (29%), Positives = 172/363 (47%), Gaps = 34/363 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHG-------DMPSVPT--EVIES 389 + + ++PGDGIGP + +V+E + H D VP E +E Sbjct: 3 KQILILPGDGIGPEIMAEAVKVLELANDKFQLGFSLAHDVIGGAAIDKHGVPLADETLER 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------P 530 R+ L G + P + L++R +L L+A+L P L P Sbjct: 63 ARKADAVLLGAVGGPKWDKIERDIRPERGLLKIRSQLGLFANLRPAILYPQLADASSLKP 122 Query: 531 TRHENVDIAVIRENTEGEYSGL---EHEVVPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE T G Y G + E+ G ++ + SE RIA+ F+ A + Sbjct: 123 EIVSGLDILIVRELTGGIYFGAPRGQRELEGGERQAYDTLPYSESEVRRIARVGFDMARV 182 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V KAN++ + L+ E +VA YP ++ + + VDN MQLV P+QFDVM Sbjct: 183 RG-KKLCSVDKANVLASSQ-LWREVVEDVAKDYPDVELSHMYVDNAAMQLVRAPKQFDVM 240 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQ-GASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ A+ + D+ ++E SA ++ I ANP Sbjct: 241 VTDNMFGDILSDEASMLTGSIGMLPSASLDADNKGMYEPCHGSAPDIAGLGI-----ANP 295 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVI 1214 +A LS +MMLR+ + A+ +E AV V+ +G RT D+ TQE+ DAV+ Sbjct: 296 LATILSVSMMLRYSFNQSAAAEAIEKAVSLVLDQG-LRTGDIFSEGCRKVGTQEMGDAVV 354 Query: 1215 AKL 1223 A L Sbjct: 355 AAL 357
>Q6D0G7:LEU3_ERWCT 3-isopropylmalate dehydrogenase - Erwinia carotovora subsp.| atroseptica (Pectobacterium atrosepticum) Length = 363 Score = 110 bits (275), Expect = 2e-23 Identities = 109/357 (30%), Positives = 163/357 (45%), Gaps = 34/357 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP----VCFETYEVHG-----DMPSVPTEVIESIR 395 + ++PGDGIGP V +V++A+ + Y+V G +P + Sbjct: 7 IAVLPGDGIGPEVMAQAHKVLDAVRQRFGIRITTSEYDVGGIAIDRQGTPLPQATVAGCE 66 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+++L GL P R + Sbjct: 67 QADAILFGSVGGPKWEHLPPAEQPERGALLPLRKHFKLFSNLRPARLYQGLEAFCPLRSD 126 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVE---SLKVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA AFE A Sbjct: 127 IAAKGFDILCVRELTGGIYFGQPKGREGSGQYERAFDTEVYHRFEIERIAHIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R VT++ KAN+++ + L+ E EVA YP ++ + + +DN MQL+ P QFDVM+ Sbjct: 186 RRSIVTSIDKANVLQ-SSILWREIVTEVAKAYPDVKLSHLYIDNATMQLIKDPSQFDVML 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKDI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST---TQEVTDAV 1211 A LS A++LR+ L A+ +E AV +AEG YRT DL S T E+ D + Sbjct: 300 AQILSLALLLRYSLGADDAAEAIEKAVNTALAEG-YRTADLASASNAIGTSEMGDVI 355
>Q726X1:LEU3_DESVH 3-isopropylmalate dehydrogenase - Desulfovibrio vulgaris (strain| Hildenborough / ATCC 29579 / NCIMB 8303) Length = 357 Score = 110 bits (275), Expect = 2e-23 Identities = 106/341 (31%), Positives = 157/341 (46%), Gaps = 31/341 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMH---------APVCFETYEVHGDMPSVPTEVIESIR 395 + L+PGDGIGP + +V++A+ + + +P +E+ R Sbjct: 5 ICLLPGDGIGPEIVAQGTKVLDAVARRFGHTVSTSSALIGGAAIDATGSPLPDATVEACR 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGLP--------T 533 + L G + P + S L +RK L L+A+L P L Sbjct: 65 TSDAVLLGAVGGPKWDDLPSEKRPEKGLLGIRKALGLFANLRPAALFPELAGACLLRADI 124 Query: 534 RHENVDIAVIRENTEGEYSGLEH--EVVPGVVESLKVMTKFCSE--RIAKYAFEYAYLNN 701 +D+ V+RE T Y G E G+ M E RIA+ AF+ A Sbjct: 125 AAAGLDLVVVRELTGDVYFGQPAGIETRDGLRTGFNTMIYDEDEVRRIARVAFDTARARK 184 Query: 702 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 R+ V +V KAN++ + L+ E EVA YP ++ + + VDN MQLV P QFDV+VT Sbjct: 185 RR-VCSVDKANVLATSR-LWREVVEEVARDYPDVELSHMYVDNAAMQLVRWPAQFDVIVT 242 Query: 882 PNLYGNLVSNVAAGIAXXXXXXXXXXXXQ-DHAVFE--QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ AA I A+FE G++ G D KANP+ Sbjct: 243 GNLFGDILSDEAAVITGSIGMLPSASMGSGGPALFEPIHGSAPDIAGQD------KANPI 296 Query: 1053 ALFLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDL 1172 A LS MMLR + AD +++AV+ V+AEG YRT D+ Sbjct: 297 ATILSVGMMLRLGFGLAAEADAIDAAVRRVLAEG-YRTGDI 336
>Q4KF05:LEU3_PSEF5 3-isopropylmalate dehydrogenase - Pseudomonas fluorescens (strain| Pf-5 / ATCC BAA-477) Length = 360 Score = 110 bits (274), Expect = 2e-23 Identities = 109/363 (30%), Positives = 174/363 (47%), Gaps = 34/363 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVC--FE-TYEVHG----DMPSVPT--EVIES 389 + + ++PGDGIGP + +V+E + FE +++V G D VP E ++ Sbjct: 3 KQILILPGDGIGPEIMAEAVKVLELANDKYSLGFELSHDVIGGAAIDKHGVPLADETLDR 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------P 530 R L G + P + L++R +L L+ +L P L P Sbjct: 63 ARAADAVLLGAVGGPKWDKIERDIRPERGLLKIRAQLGLFGNLRPAILYPQLADASSLKP 122 Query: 531 TRHENVDIAVIRENTEGEYSGLEH---EVVPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE T G Y G E+ G +S + SE RIA+ F+ A + Sbjct: 123 EIVSGLDILIVRELTGGIYFGAPRGTRELENGERQSYDTLPYSESEIRRIARVGFDMARV 182 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V KAN++ + L+ E +VA YP ++ + + VDN MQLV P+QFDV+ Sbjct: 183 RG-KKLCSVDKANVLASSQ-LWREVVEQVAKDYPDVELSHMYVDNAAMQLVRAPKQFDVI 240 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQ-GASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ A+ + ++ ++E SA ++ I ANP Sbjct: 241 VTDNMFGDILSDEASMLTGSIGMLPSASLDANNKGMYEPCHGSAPDIAGQGI-----ANP 295 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVI 1214 +A LS +MMLR+ AD +E AV V+ +G RT D+ TQE+ DAV+ Sbjct: 296 LATILSVSMMLRYSFNLTEAADAIEQAVSRVLDQG-LRTGDIWSAGCTKVGTQEMGDAVV 354 Query: 1215 AKL 1223 A L Sbjct: 355 AAL 357
>Q32K21:LEU3_SHIDS 3-isopropylmalate dehydrogenase - Shigella dysenteriae serotype 1| (strain Sd197) Length = 363 Score = 109 bits (273), Expect = 3e-23 Identities = 106/359 (29%), Positives = 164/359 (45%), Gaps = 33/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS---------VPTEVIESIR 395 + +PGDGIGP V +V++A+ H D+ +P +E Sbjct: 7 IAALPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 Query: 396 RNKVCLKGGLATPVGGGVS-------SLNLQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+++L GL P R + Sbjct: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVESL---KVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA+ AFE A Sbjct: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R KVT++ KAN+++ + L+ E E+AT+YP ++ + +DN MQL+ P QFDV++ Sbjct: 186 RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVIAK 1220 A LS A++LR+ L A +E A+ + EG RTRDL G + + + +IA+ Sbjct: 300 AQILSLALLLRYSLDADDAASAIERAINRALEEG-IRTRDLARGAAAVSTDEMGDIIAR 357
>Q9KP82:LEU3_VIBCH 3-isopropylmalate dehydrogenase - Vibrio cholerae| Length = 363 Score = 109 bits (272), Expect = 3e-23 Identities = 103/344 (29%), Positives = 158/344 (45%), Gaps = 31/344 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSV---------PTEVIESIR 395 + ++PGDGIGP V +V++A+ D+ + P + + Sbjct: 8 IAVLPGDGIGPEVMAQAHKVLDAIEQKHGIRFSREEHDVGGIAIDNHGCPLPESTLRACE 67 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 L G + P + L LRK L+ +L GL P R + Sbjct: 68 EADAVLFGSVGGPKWEHLPPNEQPERGALLPLRKHFQLFCNLRPAQIHQGLEAFSPLRAD 127 Query: 543 ----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 DI V+RE T G Y G E E +V +F ERIA+ AFE A L Sbjct: 128 ISARGFDIVVVRELTGGIYFGQPKGREGEGAHEKAFDTEVYHRFEIERIARIAFESARLR 187 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 RKKV ++ KAN+++ + L+ E E+A +YP + + + +DN MQL+ P QFDVM+ Sbjct: 188 -RKKVCSIDKANVLQ-SSILWREVVSEIAKEYPDVSLSHMYIDNATMQLIKDPAQFDVML 245 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE-QGASAGNVGNDKILQQKKANPV 1052 N++G+++S+ A I + ++E G SA ++ I ANPV Sbjct: 246 CSNIFGDILSDECAMITGSMGMLPSASMNESKFGLYEPAGGSAPDIAGKNI-----ANPV 300 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGT 1181 A LS+A+MLR+ L + A +E+AV +A G+ T DL G+ Sbjct: 301 AQILSAALMLRYSLGEEAAARDIENAVSQALAAGEL-TADLAGS 343
>Q6G7Q0:LEU3_STAAS 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain| MSSA476) Length = 348 Score = 109 bits (272), Expect = 3e-23 Identities = 97/351 (27%), Positives = 158/351 (45%), Gaps = 23/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM--PSVPT-------EVIESIR 395 + +PGDGIGP + ++E + F H + S+ T + + + + Sbjct: 5 IVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLNACK 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGLPT-------RHE 542 R L G + P ++ L+LRK L+L+A++ + G + R E Sbjct: 65 RADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKEERVE 124 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 D+ ++RE T G Y G T+ ERI AF+ A + R K+T+V Sbjct: 125 GTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLA-ASRRGKLTSV 183 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 K N++ + L+ + EV+ YP + N ++VD C M L+ P+QFDV+V NL+G++ Sbjct: 184 DKENVLA-SSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIVCENLFGDI 242 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQ--GASAGNVGNDKILQQKKANPVALFLSSAM 1076 +S+ A+ I D + SA ++ + ANP + LS AM Sbjct: 243 LSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNV-----ANPFGMILSLAM 297 Query: 1077 MLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 LR L P AD LE + +I G+ T DLGG T ++ + + KL+ Sbjct: 298 CLRESLNQPDAADELEQHIYNMIEHGQ-TTADLGGKLNTTDIFEILSQKLN 347
>P65101:LEU3_STAAN 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain N315)| Length = 348 Score = 109 bits (272), Expect = 3e-23 Identities = 97/351 (27%), Positives = 158/351 (45%), Gaps = 23/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM--PSVPT-------EVIESIR 395 + +PGDGIGP + ++E + F H + S+ T + + + + Sbjct: 5 IVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLNACK 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGLPT-------RHE 542 R L G + P ++ L+LRK L+L+A++ + G + R E Sbjct: 65 RADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKEERVE 124 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 D+ ++RE T G Y G T+ ERI AF+ A + R K+T+V Sbjct: 125 GTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLA-ASRRGKLTSV 183 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 K N++ + L+ + EV+ YP + N ++VD C M L+ P+QFDV+V NL+G++ Sbjct: 184 DKENVLA-SSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIVCENLFGDI 242 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQ--GASAGNVGNDKILQQKKANPVALFLSSAM 1076 +S+ A+ I D + SA ++ + ANP + LS AM Sbjct: 243 LSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNV-----ANPFGMILSLAM 297 Query: 1077 MLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 LR L P AD LE + +I G+ T DLGG T ++ + + KL+ Sbjct: 298 CLRESLNQPDAADELEQHIYNMIEHGQ-TTADLGGKLNTTDIFEILSQKLN 347
>P65100:LEU3_STAAM 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain Mu50| / ATCC 700699) Length = 348 Score = 109 bits (272), Expect = 3e-23 Identities = 97/351 (27%), Positives = 158/351 (45%), Gaps = 23/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM--PSVPT-------EVIESIR 395 + +PGDGIGP + ++E + F H + S+ T + + + + Sbjct: 5 IVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLNACK 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGLPT-------RHE 542 R L G + P ++ L+LRK L+L+A++ + G + R E Sbjct: 65 RADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKEERVE 124 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 D+ ++RE T G Y G T+ ERI AF+ A + R K+T+V Sbjct: 125 GTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLA-ASRRGKLTSV 183 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 K N++ + L+ + EV+ YP + N ++VD C M L+ P+QFDV+V NL+G++ Sbjct: 184 DKENVLA-SSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIVCENLFGDI 242 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQ--GASAGNVGNDKILQQKKANPVALFLSSAM 1076 +S+ A+ I D + SA ++ + ANP + LS AM Sbjct: 243 LSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNV-----ANPFGMILSLAM 297 Query: 1077 MLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 LR L P AD LE + +I G+ T DLGG T ++ + + KL+ Sbjct: 298 CLRESLNQPDAADELEQHIYNMIEHGQ-TTADLGGKLNTTDIFEILSQKLN 347
>Q92KY8:LEU3_RHIME 3-isopropylmalate dehydrogenase - Rhizobium meliloti (Sinorhizobium| meliloti) Length = 370 Score = 109 bits (272), Expect = 3e-23 Identities = 114/377 (30%), Positives = 172/377 (45%), Gaps = 49/377 (12%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAP-----------VCFETYEVHGDMPSVPTEVI 383 R + L+PGDGIGP VR+++ M+A V Y+ HG S ++ Sbjct: 4 RNLFLLPGDGIGPEAMAEVRKIIAYMNAERDAGFVTDEGLVGGSAYDAHGAAIS-EGDMA 62 Query: 384 ESIRRNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGL------ 527 +++ + V L G + P V + L+LRK+L+L+A+L P L Sbjct: 63 KALAADAV-LFGAVGGPKWDAVPYEVRPEAGLLRLRKDLELFANLRPAICYPALANASSL 121 Query: 528 -PTRHENVDIAVIRENTEGEYSGLEHEVVP-------GVVESLKVMTKFCSERIAKYAFE 683 P E +DI ++RE T G Y G E+V G+ +V + ERIA AFE Sbjct: 122 KPELVEGLDILIVRELTGGVYFGEPKEIVDLGNGQKRGI--DTQVYDTYEIERIAGVAFE 179 Query: 684 YAYLNNRKKVTAVHKANIMKLADGLFLESCREV-ATKYPGIQYNEIIVDNCCMQLVAKPE 860 A N + V ++ K N+MK + L+ + E KY +Q ++ D MQLV +P+ Sbjct: 180 LARTRNNR-VCSMEKRNVMK-SGVLWNQVVTETHKAKYSDVQLEHMLADAGGMQLVRQPK 237 Query: 861 QFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQK- 1037 QFDV+VT NL+G+++S+VAA + GA G K L + Sbjct: 238 QFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSA---------SLGAPDAKTGKRKALYEPV 288 Query: 1038 -----------KANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGT 1181 ANP+A+ S AM LR+ AD LE A+ V+ +G RT D+ Sbjct: 289 HGSAPDIAGTGVANPIAMIASFAMCLRYSFNLVKEADDLEKAIANVLDQG-IRTGDIMAE 347 Query: 1182 ST----TQEVTDAVIAK 1220 T E+ DA++A+ Sbjct: 348 GCRKVGTAEMGDAILAE 364
>Q9JZI9:LEU3_NEIMB 3-isopropylmalate dehydrogenase - Neisseria meningitidis serogroup B| Length = 356 Score = 109 bits (272), Expect = 3e-23 Identities = 106/361 (29%), Positives = 174/361 (48%), Gaps = 34/361 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM----------HAPVCFETYEVHGDMPSVPTEVIESI 392 + ++ GDGIGP + +V++ + +AP+ E Y+ +G P Sbjct: 5 IAILRGDGIGPEIVAETVRVLDKLIAQGLDAGYEYAPLGGEAYDEYGH--PYPEFTQNLC 62 Query: 393 RRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------PT 533 R+ L G + +P + L +RK+L+L+A+L P L P Sbjct: 63 RKADAVLLGAVGSPQYDNLDRPLRPERGLLAIRKDLNLFANLRPAVLYPELANASTLKPE 122 Query: 534 RHENVDIAVIRENTEGEYSGLEHEV---VPGVVESLKVMTKFCSE--RIAKYAFEYAYLN 698 +DI ++RE T Y G + G E M SE RIA AF+ A Sbjct: 123 IVAGLDILIVRELTGDIYFGEPRGIRVLENGEREGYNTMKYSESEIRRIAHVAFQSAQKR 182 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 + KKV +V KAN+++ + L+ E E+ +YP ++ + + VDN MQLV P+QFDV+ Sbjct: 183 S-KKVCSVGKANVLETTE-LWREIFEEIGKEYPDVELSHMYVDNAAMQLVRAPKQFDVIA 240 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQGASAGNVGNDKILQQKKANPVA 1055 T N++G+++S+ A+ + ++ ++E + I Q KANP+A Sbjct: 241 TGNIFGDILSDEASMLTGSIGMLPSASLDENGKGLYEPSHGSA----PDIAGQNKANPLA 296 Query: 1056 LFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTS--TTQEVTDAVIAK 1220 LS AM+LR+ L + A ++E+AV+ V+ +G RT D+ GT + E+ DAV+A Sbjct: 297 TILSLAMLLRYSLNDEARAQQVENAVQKVLQQG-LRTSDIYEEGTKLVSCSEMGDAVLAA 355 Query: 1221 L 1223 L Sbjct: 356 L 356
>P93832:LEU32_ARATH 3-isopropylmalate dehydrogenase 2, chloroplast precursor -| Arabidopsis thaliana (Mouse-ear cress) Length = 405 Score = 109 bits (272), Expect = 3e-23 Identities = 110/369 (29%), Positives = 173/369 (46%), Gaps = 40/369 (10%) Frame = +3 Query: 240 TVTLIPGDGIGPLVTGAVRQVMEAMHA----PVCFETYEVHG---DMPSVPT--EVIESI 392 T+TL+PGDGIGP V + V++ + F + G D+ VP E I + Sbjct: 44 TITLLPGDGIGPEVVSIAKNVLQQAGSLEGVEFNFREMPIGGAALDLVGVPLPEETISAA 103 Query: 393 RRNKVCLKGGLATPVGGGVSSLN-----------LQLRKELDLYASLVNCFNLPGLPTRH 539 + + L G + GG N LQ+R L ++A+L LP L Sbjct: 104 KESDAVLLGAI-----GGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPATVLPQLVDAS 158 Query: 540 -------ENVDIAVIRENTEGEYSGLEHEVVPG-----VVESLKVMTKFCSERIAKYAFE 683 E VD+ V+RE T G Y G + V + +V +RIA+ AFE Sbjct: 159 TLKREVAEGVDLMVVRELTGGIYFGEPRGIKTNENGEEVGFNTEVYAAHEIDRIARVAFE 218 Query: 684 YAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQ 863 A R K+ +V KAN+++ A L+ + +A++YP ++ + + VDN MQLV P+Q Sbjct: 219 TAR-KRRGKLCSVDKANVLE-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQ 276 Query: 864 FDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQ 1034 FD +VT N++G+++S+ A+ I +FE G++ G D Sbjct: 277 FDTIVTNNIFGDILSDEASMITGSIGMLPSASLSDSGPGLFEPIHGSAPDIAGQD----- 331 Query: 1035 KKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEV 1199 KANP+A LS+AM+L++ L A R+E AV + G +RT D+ T +E+ Sbjct: 332 -KANPLATILSAAMLLKYGLGEEKAAKRIEDAVLVALNNG-FRTGDIYSAGTKLVGCKEM 389 Query: 1200 TDAVIAKLD 1226 + V+ +D Sbjct: 390 GEEVLKSVD 398
>Q8NVJ0:LEU3_STAAW 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain MW2)| Length = 348 Score = 108 bits (271), Expect = 4e-23 Identities = 98/351 (27%), Positives = 159/351 (45%), Gaps = 23/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM--PSVPT-------EVIESIR 395 + +PGDGIGP + ++E + F H + S+ T + + + + Sbjct: 5 IVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLNACK 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGL----PTRHENV- 548 R L G + P ++ L+LRK L+L+A++ + G P + E V Sbjct: 65 RADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKEERVE 124 Query: 549 --DIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 D+ ++RE T G Y G T+ ERI AF+ A + R K+T+V Sbjct: 125 GKDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLA-ASRRGKLTSV 183 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 K N++ + L+ + EV+ YP + N ++VD C M L+ P+QFDV+V NL+G++ Sbjct: 184 DKENVLA-SSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIVCENLFGDI 242 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQ--GASAGNVGNDKILQQKKANPVALFLSSAM 1076 +S+ A+ I D + SA ++ + ANP + LS AM Sbjct: 243 LSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNV-----ANPFGMILSLAM 297 Query: 1077 MLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 LR L P AD LE + +I G+ T DLGG T ++ + + KL+ Sbjct: 298 CLRESLNQPDAADELEQHIYNMIEHGQ-TTADLGGKLNTTDIFEILSQKLN 347
>Q6GF15:LEU3_STAAR 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain| MRSA252) Length = 348 Score = 108 bits (271), Expect = 4e-23 Identities = 98/356 (27%), Positives = 163/356 (45%), Gaps = 28/356 (7%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM--PSVPT-------EVIESIR 395 + +PGDGIGP + ++E + F H + S+ T + + + + Sbjct: 5 IVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLNACK 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGLPT-------RHE 542 R L G + P ++ L+LRK L+L+A++ + G + R E Sbjct: 65 RADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKAERVE 124 Query: 543 NVDIAVIRENTEGEYSGL-----EHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRK 707 D+ ++RE T G Y G HE + + + + + ERI AF+ A + R Sbjct: 125 GTDLVIVRELTSGIYFGEPRYFNNHEALDSLTYTREEI-----ERIVHVAFKLA-ASRRG 178 Query: 708 KVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPN 887 K+T+V K N++ + L+ + EV+ YP + N ++VD C M L+ P+QFDV+V N Sbjct: 179 KLTSVDKENVLA-SSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIVYEN 237 Query: 888 LYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQ--GASAGNVGNDKILQQKKANPVALF 1061 L+G+++S+ A+ I D + SA ++ + ANP + Sbjct: 238 LFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNV-----ANPFGMI 292 Query: 1062 LSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 LS AM LR L P AD LE + +I G+ T DLGG T ++ + + KL+ Sbjct: 293 LSLAMCLRESLNQPDAADELEQHIYNMIEHGQ-TTADLGGKLNTTDIFEILSQKLN 347
>Q2YUF1:LEU3_STAAB 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain| bovine RF122) Length = 348 Score = 108 bits (271), Expect = 4e-23 Identities = 97/351 (27%), Positives = 157/351 (44%), Gaps = 23/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM--PSVPT-------EVIESIR 395 + +PGDGIGP + ++E + F H + S+ T + + + + Sbjct: 5 IVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLNACK 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGLPT-------RHE 542 R L G + P ++ L+LRK L+L+A++ G + R E Sbjct: 65 RADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVFKGASSLSPLKQERVE 124 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 D+ ++RE T G Y G T+ ERI AF+ A + R K+T+V Sbjct: 125 GTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLA-ASRRGKLTSV 183 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 K N++ + L+ + EV+ YP + N ++VD C M L+ P+QFDV+V NL+G++ Sbjct: 184 DKENVLA-SSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIVCENLFGDI 242 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQ--GASAGNVGNDKILQQKKANPVALFLSSAM 1076 +S+ A+ I D + SA ++ + ANP + LS AM Sbjct: 243 LSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNV-----ANPFGMILSLAM 297 Query: 1077 MLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 LR L P AD LE + +I G+ T DLGG T ++ + + KL+ Sbjct: 298 CLRESLNQPDAADELEQHIYNMIENGQ-TTADLGGKLNTTDIFEILSQKLN 347
>Q2NVW4:LEU3_SODGM 3-isopropylmalate dehydrogenase - Sodalis glossinidius (strain| morsitans) Length = 364 Score = 108 bits (271), Expect = 4e-23 Identities = 106/359 (29%), Positives = 165/359 (45%), Gaps = 34/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM----HAPVCFETYEVHGDM-----PSVPTEVIESIR 395 + ++PGDGIGP V ++++A+ + + Y+V G +P + Sbjct: 8 IAVLPGDGIGPEVMAQAYKILDAVRQRFNVRISTSEYDVGGAAIDRQGSPLPAGTVAGCE 67 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTR-- 536 + L G + P + + L LRK L+++L PGL P R Sbjct: 68 QADAILFGSVGGPKWEHLPAAEQPERGALLPLRKHFKLFSNLRPSRLYPGLEAYCPLRAN 127 Query: 537 --HENVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G E +V +F ERIA+ AFE A Sbjct: 128 IAERGFDILCVRELTGGIYFGQPKGREGTGPHEHAFDTEVYYRFEIERIARIAFESAR-K 186 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R KVT++ KAN+++ + L+ + +VA YP + + + +DN MQL+ P QFDVM+ Sbjct: 187 RRGKVTSIDKANVLQ-SSILWRKVVSQVAPDYPDVALSHLYIDNATMQLIKDPSQFDVML 245 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANPV Sbjct: 246 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGMYEPAGGSAPDIAGKDI-----ANPV 300 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST---TQEVTDAVIA 1217 A LS++++LR+ L AD +E AV + G +RT DL G + T E+ D + A Sbjct: 301 AQILSASLLLRYSLGLDDAADAIELAVNQALEAG-HRTADLAGGGSAVGTGEMGDIIAA 358
>Q8Z9I1:LEU3_SALTI 3-isopropylmalate dehydrogenase - Salmonella typhi| Length = 363 Score = 108 bits (271), Expect = 4e-23 Identities = 106/359 (29%), Positives = 168/359 (46%), Gaps = 33/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP----VCFETYEVHGDMPS-----VPTEVIESIR 395 + ++PGDGIGP V +VM+A+ + + Y+V G +P +E Sbjct: 7 IAVLPGDGIGPEVMAQALKVMDAVRSRFDMRITTSRYDVGGIAIDNHGHPLPKATVEGCE 66 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + + L LRK L+++L GL P R + Sbjct: 67 QADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVESL---KVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA+ AFE A Sbjct: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R+KVT++ KAN+++ + L+ E +VA YP ++ + +DN MQL+ P QFDV++ Sbjct: 186 RRRKVTSIDKANVLQ-SSILWREIVNDVAKAYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q+ ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQEFGLYEPAGGSAPDIAGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVIAK 1220 A LS A++LR+ L A +E A+ + EG RT DL G + + + +IA+ Sbjct: 300 AQILSLALLLRYSLDADEAATAIEQAINRALEEG-VRTSDLARGAAAVSTDEMGDIIAR 357
>Q2K2V0:LEU3_RHIEC 3-isopropylmalate dehydrogenase - Rhizobium etli (strain CFN 42 /| ATCC 51251) Length = 370 Score = 108 bits (271), Expect = 4e-23 Identities = 115/377 (30%), Positives = 174/377 (46%), Gaps = 49/377 (12%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVM----EAMHAPVCFE-------TYEVHGDMPSVPTEVI 383 R + L+PGDGIGP G VR+++ EAM A + Y+ HG S ++ Sbjct: 4 RNLFLLPGDGIGPEAMGEVRKIIAYMNEAMDAGFVTDEGLVGGCAYDAHGAAIS-EADMQ 62 Query: 384 ESIRRNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGL------ 527 +++ + V L G + P V + L+LRK+L L+A+L P L Sbjct: 63 KALAADAV-LFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASASSL 121 Query: 528 -PTRHENVDIAVIRENTEGEYSGLEHEVVP-------GVVESLKVMTKFCSERIAKYAFE 683 P E +DI +IRE T G Y G E++ G+ +V + ERIA AFE Sbjct: 122 KPELVEGLDILIIRELTGGVYFGEPKEIIDLGNGQKRGI--DTQVYDTYEIERIAGVAFE 179 Query: 684 YAYLNNRKKVTAVHKANIMKLADGLFLESCREV-ATKYPGIQYNEIIVDNCCMQLVAKPE 860 A + +V ++ K N+MK + L+ + E KY +Q ++ D MQLV +P+ Sbjct: 180 MAR-TRQNRVCSMEKRNVMK-SGVLWNQVVTETHKAKYSDVQLEHMLADAGGMQLVRQPK 237 Query: 861 QFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKK 1040 QFDV+VT NL+G+++S+VAA + GA G G K L + Sbjct: 238 QFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSA---------SLGAPDGKTGKRKALYEPV 288 Query: 1041 ------------ANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGT 1181 ANP+A+ S AM LR+ AD LE A+ V+ +G RT D+ Sbjct: 289 HGSAPDIAGKGIANPIAMIASFAMCLRYSFNMVKEADDLEKAIANVLDKG-IRTGDIMAD 347 Query: 1182 STTQ----EVTDAVIAK 1220 Q E+ +A++A+ Sbjct: 348 GCRQVGTVEMGEAILAE 364
>Q5FUG5:LEU3_GLUOX 3-isopropylmalate dehydrogenase - Gluconobacter oxydans| (Gluconobacter suboxydans) Length = 369 Score = 108 bits (271), Expect = 4e-23 Identities = 111/350 (31%), Positives = 167/350 (47%), Gaps = 42/350 (12%) Frame = +3 Query: 249 LIPGDGIGPLVTGAVRQVMEAM--HAPVCFETYE---------VHGDMPSVPTEVIESIR 395 ++ GDGIGP V V +++ M H + E E VHG + EVIE R Sbjct: 9 VLAGDGIGPEVMREVARIVHWMSAHRGLKLEITEELVGAASLAVHG--VPIRDEVIELAR 66 Query: 396 RNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------PTR 536 ++ L G + P V L+LRKEL+L+A+L L P Sbjct: 67 QSDAVLFGSVGDPAWSHVGFDKRPEVAILKLRKELELFANLRPAKLFDALIDASALKPEV 126 Query: 537 HENVDIAVIRENTEGEYSGLEH--EVVPGVVE---SLKVMTKFCSERIAKYAFEYAYLNN 701 +D+ ++RE G Y G E +P + +V T ER+A+ AF+ A + Sbjct: 127 VRGLDLMIVRETVGGIYFGEPRGIETLPDGSRRGINTEVYTTSEIERVARVAFDLARKRD 186 Query: 702 RKKVTAVHKANIMKLADGLFLESCREVAT-----KYPGIQYNEIIVDNCCMQLVAKPEQF 866 + V +V K N+M+ GL +EV T +YP +Q + ++ DNC MQLV P QF Sbjct: 187 NR-VCSVEKCNVME--SGLLW---KEVVTDVHKREYPDVQLSHMLADNCAMQLVRDPNQF 240 Query: 867 DVMVTPNLYGNLVSNVAA------GIAXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKI 1025 DV+VT NL+G+++S++A+ G+ + +A++E SA ++ I Sbjct: 241 DVIVTGNLFGDILSDLASMLTGSLGMLPSATLGPVRADGKRNALYEPIHGSAPDIAGKGI 300 Query: 1026 LQQKKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL 1172 ANP+A LS AM+LR+ L AD +E AV V+A G RT D+ Sbjct: 301 -----ANPLAQILSFAMLLRYSLNRAEDADLIEMAVSNVLASG-LRTGDI 344
>P37412:LEU3_SALTY 3-isopropylmalate dehydrogenase - Salmonella typhimurium| Length = 363 Score = 108 bits (270), Expect = 6e-23 Identities = 105/359 (29%), Positives = 165/359 (45%), Gaps = 33/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSV---------PTEVIESIR 395 + ++PGDGIGP V +VM+A+ + H D+ + P +E Sbjct: 7 IAVLPGDGIGPEVMAQALKVMDAVRSRFDMRITTSHYDVGGIAIDNHGHPLPKATVEGCE 66 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + + L LRK L+++L GL P R + Sbjct: 67 QADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVESL---KVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA+ AFE A Sbjct: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R+KVT++ KAN+++ + L+ E +VA YP ++ + +DN MQL+ P QFDV++ Sbjct: 186 RRRKVTSIDKANVLQ-SSILWREIVNDVAKTYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVIAK 1220 A LS A++LR+ L A +E A+ + EG RT DL G + + + +IA+ Sbjct: 300 AQILSLALLLRYSLDANDAATAIEQAINRALEEG-VRTGDLARGAAAVSTDEMGDIIAR 357
>Q57TE7:LEU3_SALCH 3-isopropylmalate dehydrogenase - Salmonella choleraesuis| Length = 363 Score = 108 bits (270), Expect = 6e-23 Identities = 105/359 (29%), Positives = 165/359 (45%), Gaps = 33/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPSV---------PTEVIESIR 395 + ++PGDGIGP V +VM+A+ + H D+ + P +E Sbjct: 7 IAVLPGDGIGPEVMAQALKVMDAVRSRFDMRITTSHYDVGGIAIDNHGHPLPKATVEGCE 66 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + + L LRK L+++L GL P R + Sbjct: 67 QADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVESL---KVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA+ AFE A Sbjct: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R+KVT++ KAN+++ + L+ E +VA YP ++ + +DN MQL+ P QFDV++ Sbjct: 186 RRRKVTSIDKANVLQ-SSILWREIVNDVAKTYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVIAK 1220 A LS A++LR+ L A +E A+ + EG RT DL G + + + +IA+ Sbjct: 300 AQILSLALLLRYSLDANDAATAIEQAINRALEEG-VRTGDLARGAAAVSTDEMGDIIAR 357
>Q3KF21:LEU3_PSEPF 3-isopropylmalate dehydrogenase - Pseudomonas fluorescens (strain| PfO-1) Length = 360 Score = 108 bits (270), Expect = 6e-23 Identities = 109/363 (30%), Positives = 174/363 (47%), Gaps = 34/363 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVC--FE-TYEVHG----DMPSVPT--EVIES 389 + + ++PGDGIGP + +V+E + FE +++V G D VP E ++ Sbjct: 3 KQILILPGDGIGPEIMAEAVKVLELANEKYSLGFELSHDVIGGAAIDKHGVPLADETLDR 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------P 530 R L G + P + L++R +L L+ +L P L P Sbjct: 63 ARAADAVLLGAVGGPKWDTIERDIRPERGLLKIRAQLGLFGNLRPAILYPQLADASSLKP 122 Query: 531 TRHENVDIAVIRENTEGEYSGLEH---EVVPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE T G Y G + G +S + SE RIA+ F+ A + Sbjct: 123 EIAAGLDILIVRELTGGIYFGAPRGTRTLENGERQSYDTLPYSESEIRRIARVGFDMARV 182 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V KAN++ + L+ E +VA YP ++ + + VDN MQLV P+QFDV+ Sbjct: 183 RG-KKLCSVDKANVLASSQ-LWREVVEQVAKDYPDVELSHMYVDNAAMQLVRAPKQFDVI 240 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQ-GASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ A+ + ++ ++E SA ++ I ANP Sbjct: 241 VTDNMFGDILSDEASMLTGSIGMLPSASLDANNKGMYEPCHGSAPDIAGKGI-----ANP 295 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVI 1214 +A LS +MMLR+ AD +E AV V+ +G RT D+ T TQE+ DAV+ Sbjct: 296 LATILSVSMMLRYSFNLHEAADAIEKAVSVVLDQG-LRTGDIFSTGCTKVGTQEMGDAVV 354 Query: 1215 AKL 1223 A L Sbjct: 355 AAL 357
>Q7V842:LEU3_PROMM 3-isopropylmalate dehydrogenase - Prochlorococcus marinus (strain MIT| 9313) Length = 357 Score = 108 bits (270), Expect = 6e-23 Identities = 105/347 (30%), Positives = 166/347 (47%), Gaps = 30/347 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM---HA-PVCFETYEVHG-----DMPSVPTEVIESIR 395 + L+PGDGIGP +T + +++A+ H + FE + + G +P +E+ + Sbjct: 6 IVLLPGDGIGPEITAVAKLLLDALGHQHGFKLNFEQHPIGGVAIDASGSPLPASTLEACQ 65 Query: 396 RNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGLPTRH------ 539 + L + +P + L LR L L+A+L LP L Sbjct: 66 ASDAVLLAAIGSPRFDALPREQRPETGLLSLRAGLKLFANLRPVTILPALIDASSLKANV 125 Query: 540 -ENVDIAVIRENTEGEYSGLEHEVVP--GVVESLKVMTKFCSE--RIAKYAFEYAYLNNR 704 + VD+ V+RE T G Y G + G + MT +E RIAK AFE A + Sbjct: 126 IKGVDLMVVRELTGGIYFGQPKGRIEADGDERAFNTMTYSRTEVDRIAKVAFELAR-DRS 184 Query: 705 KKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTP 884 K+ +V KAN++ ++ L+ + +A Y ++ + + VDN MQLV P QFDV++T Sbjct: 185 GKLCSVDKANVLDVSQ-LWRDRVDALAANYGDVELSHMYVDNAAMQLVRNPRQFDVLLTG 243 Query: 885 NLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFE--QGASAGNVGNDKILQQKKANPVA 1055 NL+G+++S+ AA + + +FE G++ G D ANP+A Sbjct: 244 NLFGDILSDEAAMLTGSIGMLPSASLGSEGPGLFEPVHGSAPDIAGQD------LANPMA 297 Query: 1056 LFLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQ 1193 + L +AMMLR L+ A LE +V+ V+A G +RT DL TQ Sbjct: 298 MVLCAAMMLRIGLKENDAARALEGSVERVLAAG-FRTGDLMSEGCTQ 343
>Q8FL76:LEU3_ECOL6 3-isopropylmalate dehydrogenase - Escherichia coli O6| Length = 363 Score = 108 bits (270), Expect = 6e-23 Identities = 105/359 (29%), Positives = 164/359 (45%), Gaps = 33/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS---------VPTEVIESIR 395 + ++PGDGIGP V +V++A+ H D+ +P +E Sbjct: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 Query: 396 RNKVCLKGGLATPVGGGVS-------SLNLQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+++L GL P R + Sbjct: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVESL---KVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA+ AFE A Sbjct: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R KVT++ KAN+++ + L+ E E+AT+YP ++ + +DN MQL+ P QFDV++ Sbjct: 186 RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELTHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVIAK 1220 A LS A++LR+ L A +E A+ + EG RT DL G + + + +IA+ Sbjct: 300 AQILSLALLLRYSLDADDAASAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIAR 357
>Q31N34:LEU3_SYNP7 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain PCC 7942)| (Anacystis nidulans R2) Length = 365 Score = 108 bits (269), Expect = 8e-23 Identities = 108/365 (29%), Positives = 172/365 (47%), Gaps = 35/365 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM--HAPVCFETYE-------VHGDMPSVPTEVIESIR 395 +TL+PGDGIGP + ++ A+ + FE E + +P + + R Sbjct: 7 ITLLPGDGIGPEIMAVTVDILRAIGRQFDLNFEFEEALIGGSAIDATGEPLPEATLATCR 66 Query: 396 RNKVCLKGGL------ATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRH------ 539 + L + + P + L LR L L+A+L LP L Sbjct: 67 NSDAVLLAAIGGYKWDSLPRSQRPETGLLGLRAGLGLFANLRPAAILPQLVDASSLKREV 126 Query: 540 -ENVDIAVIRENTEGEYSG-----LEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNN 701 E VD+ V+RE T G Y G E + V + +RI + AF+ A Sbjct: 127 IEGVDLMVVRELTGGIYFGEPKGCFADEQGRQRAFNTMVYREDEIDRIGRVAFDIARKRG 186 Query: 702 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 K++ +V KAN+++++ L+ + + + Y ++ + + VDN MQLV P+QFD +VT Sbjct: 187 -KRLCSVDKANVLEVSQ-LWRDRMTLLGSDYADVELSHLYVDNAAMQLVRWPKQFDTIVT 244 Query: 882 PNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S++AA + + VFE G++ G D KANP+ Sbjct: 245 GNLFGDILSDIAAMLTGSIGMLPSASLGAEGPGVFEPVHGSAPDIAGQD------KANPL 298 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTT----QEVTDAVIA 1217 A LS+AMMLR+ L P A R+E+AV V+ +G YRT DL T + + DA++A Sbjct: 299 AQVLSAAMMLRYGLDEPEAAARIEAAVNQVLDQG-YRTGDLYSEGMTLVGCKGMGDALLA 357 Query: 1218 KLD*P 1232 L+ P Sbjct: 358 ALESP 362
>Q5MZ40:LEU3_SYNP6 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain ATCC| 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) Length = 365 Score = 108 bits (269), Expect = 8e-23 Identities = 108/365 (29%), Positives = 172/365 (47%), Gaps = 35/365 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM--HAPVCFETYE-------VHGDMPSVPTEVIESIR 395 +TL+PGDGIGP + ++ A+ + FE E + +P + + R Sbjct: 7 ITLLPGDGIGPEIMAVTVDILRAIGRQFDLNFEFEEALIGGSAIDATGEPLPEATLATCR 66 Query: 396 RNKVCLKGGL------ATPVGGGVSSLNLQLRKELDLYASLVNCFNLPGLPTRH------ 539 + L + + P + L LR L L+A+L LP L Sbjct: 67 NSDAVLLAAIGGYKWDSLPRSQRPETGLLGLRAGLGLFANLRPAAILPQLVDASSLKREV 126 Query: 540 -ENVDIAVIRENTEGEYSG-----LEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNN 701 E VD+ V+RE T G Y G E + V + +RI + AF+ A Sbjct: 127 IEGVDLMVVRELTGGIYFGEPKGCFADEQGRQRAFNTMVYREDEIDRIGRVAFDIARKRG 186 Query: 702 RKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 K++ +V KAN+++++ L+ + + + Y ++ + + VDN MQLV P+QFD +VT Sbjct: 187 -KRLCSVDKANVLEVSQ-LWRDRMTLLGSDYADVELSHLYVDNAAMQLVRWPKQFDTIVT 244 Query: 882 PNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE--QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S++AA + + VFE G++ G D KANP+ Sbjct: 245 GNLFGDILSDIAAMLTGSIGMLPSASLGAEGPGVFEPVHGSAPDIAGQD------KANPL 298 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTT----QEVTDAVIA 1217 A LS+AMMLR+ L P A R+E+AV V+ +G YRT DL T + + DA++A Sbjct: 299 AQVLSAAMMLRYGLDEPEAAARIEAAVNQVLDQG-YRTGDLYSEGMTLVGCKGMGDALLA 357 Query: 1218 KLD*P 1232 L+ P Sbjct: 358 ALESP 362
>Q2RV53:LEU3_RHORT 3-isopropylmalate dehydrogenase - Rhodospirillum rubrum (strain ATCC| 11170 / NCIB 8255) Length = 370 Score = 108 bits (269), Expect = 8e-23 Identities = 109/366 (29%), Positives = 170/366 (46%), Gaps = 37/366 (10%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFET---------YEVHGDMPSVPTEVI 383 + + + GDGIGP V VR+VM+ ++ FE Y+ G P V Sbjct: 5 KKILFLAGDGIGPEVMAQVRRVMDWLNQTGRTAFEVEDALVGGAAYDAQGT-PLHDDTVA 63 Query: 384 ESIRRNKVCLKGGLATPVGGGVSSLNLQ-------LRKELDLYASLVNCFNLPGLPTRH- 539 ++ + V L G + P L+ LRK+L+L+A+L L Sbjct: 64 LALAADAVLL-GAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFDALAEAST 122 Query: 540 ------ENVDIAVIRENTEGEYSGLEHEVVP---GVVESLKVMTKFCSE--RIAKYAFEY 686 +D+ ++RE T G Y G + G + E R+AK AF+ Sbjct: 123 LKTELVSGLDVMIVRELTGGVYFGQPRGISALPNGERRGVNTQVYDTHEIVRVAKVAFDL 182 Query: 687 AYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQF 866 A K++ +V KAN+M+ + L+ E ++ YP I + + DNC MQLV +P+QF Sbjct: 183 AGKRG-KRLCSVEKANVME-SGLLWREEVTKLGADYPEIALSHMYADNCAMQLVRQPKQF 240 Query: 867 DVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGND--KILQQKK 1040 DV+VT NL+G+++S+ AA + A + A V I Q K Sbjct: 241 DVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAGQDK 300 Query: 1041 ANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL---GGTST-TQEVTD 1205 ANP+A LS +MMLR+ AD +++AV+GV+A+G RT D+ G T T + D Sbjct: 301 ANPLATILSFSMMLRYSFDLAEEADLVDNAVRGVLAKG-LRTGDIFQPGKTLVGTTGMGD 359 Query: 1206 AVIAKL 1223 A++A++ Sbjct: 360 ALLAEM 365
>Q7VC80:LEU3_PROMA 3-isopropylmalate dehydrogenase - Prochlorococcus marinus| Length = 362 Score = 108 bits (269), Expect = 8e-23 Identities = 100/350 (28%), Positives = 169/350 (48%), Gaps = 36/350 (10%) Frame = +3 Query: 231 APRTVTLIPGDGIGPLVTGAVRQVMEAM-----------HAPVCFETYEVHGDMPSVPTE 377 A +TL+ GDGIGP ++ ++++ A+ P + E+ G +P + Sbjct: 2 ASHKITLLTGDGIGPEISIVAKKILAALSEKHSITFTIEEKPFGGQAIELTGK--PLPED 59 Query: 378 VIESIRRNKVCLKGGLATPVGGGVSSLNLQLRKE---LDLYASLVNCFNLPGLPTRH--- 539 + S + + L + P L LR E L+L A L N+ + R Sbjct: 60 TLNSCKASDAVLLAAIGDPK---YDDLPRDLRPETGLLNLRAGLNLFANIRPIKIRQALI 116 Query: 540 ----------ENVDIAVIRENTEGEYSG-----LEHEVVPGVVESLKVMTKFCSERIAKY 674 ++VD+ V+RE T G Y G + E + + + +RIAK Sbjct: 117 SSSSLKSEIIKDVDLVVVRELTGGIYFGQPKGRISTEEAGERAFNTMTYSDYEIDRIAKI 176 Query: 675 AFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAK 854 AF+ + RKK+ ++ KAN+++++ L+ E + +YP I+ VDN MQLV + Sbjct: 177 AFDLSE-TRRKKICSIDKANVLEVSQ-LWRERVIKAQEQYPNIELTHQYVDNAAMQLVRE 234 Query: 855 PEQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQ-GASAGNVGNDKIL 1028 P QFDV++T NL+G+++S+ AA + +D VFE SA ++ + + Sbjct: 235 PAQFDVILTSNLFGDIISDEAAMLTGSIGMLPSASLGEDGPGVFEPVHGSAPDIAHKNL- 293 Query: 1029 QQKKANPVALFLSSAMMLRH--LQFPSFADRLESAVKGVIAEGKYRTRDL 1172 ANP+A+ LS+AMMLR +++ + D LE+A+ V+ +G +RT DL Sbjct: 294 ----ANPIAMILSTAMMLRTGLMEYKAATD-LENAIDKVLGKG-FRTIDL 337
>Q8X9Z9:LEU3_ECO57 3-isopropylmalate dehydrogenase - Escherichia coli O157:H7| Length = 363 Score = 108 bits (269), Expect = 8e-23 Identities = 106/359 (29%), Positives = 164/359 (45%), Gaps = 33/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS---------VPTEVIESIR 395 + ++PGDGIGP V +V++A+ H D+ +P +E Sbjct: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 Query: 396 RNKVCLKGGLATPVGGGVS-------SLNLQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+++L GL P R + Sbjct: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVESL---KVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA+ AFE A Sbjct: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R KVT++ KAN+++ + L+ E E+AT+YP I+ + +DN MQL+ P QFDV++ Sbjct: 186 RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDIELAHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVIAK 1220 A LS A++LR+ L A +E A+ + EG RT DL G + + + +IA+ Sbjct: 300 AQILSLALLLRYSLDADDAASAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIAR 357
>Q73B99:LEU3_BACC1 3-isopropylmalate dehydrogenase - Bacillus cereus (strain ATCC 10987)| Length = 354 Score = 108 bits (269), Expect = 8e-23 Identities = 99/354 (27%), Positives = 165/354 (46%), Gaps = 24/354 (6%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAM------HAPVCFETY-----EVHGDMPSVPTEVI 383 + + + GDG+GP V + ++V+ + H + E + +++G +P + Sbjct: 3 KRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEYFGGSAIDLNGQ--PLPQRTL 60 Query: 384 ESIRRNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASL----VNCFNLPGLPTRH 539 + + L G + P L LRK L ++A++ V P + Sbjct: 61 AACLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK 120 Query: 540 -ENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVT 716 + +D V+RE T G Y E V + ERI YAF+ A +KKVT Sbjct: 121 ADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSYAFQLAS-KRKKKVT 179 Query: 717 AVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYG 896 ++ KAN+++ + L+ EVA +YP ++ I+VD M+L+ P +FDV+VT NL+G Sbjct: 180 SIDKANVLE-SSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFG 238 Query: 897 NLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAG---NVGNDKILQQKKANPVALFLS 1067 +++S+ A+ +A HA E+G S + I + KANP+A+ S Sbjct: 239 DILSDEASVLA----GSLGMLPSASHA--EKGPSLYEPIHGSAPDIAGKNKANPIAMMRS 292 Query: 1068 SAMML-RHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 AMML + +E A+ V+ GK T D+GGT TT T AV+ +++ Sbjct: 293 VAMMLGQSFGLTREGCAIEEAISAVLKLGKC-TADIGGTETTTSFTKAVMQEME 345
>Q8ZIG9:LEU3_YERPE 3-isopropylmalate dehydrogenase - Yersinia pestis| Length = 363 Score = 107 bits (268), Expect = 1e-22 Identities = 106/360 (29%), Positives = 163/360 (45%), Gaps = 34/360 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHA----PVCFETYEVHGDM-----PSVPTEVIESIR 395 + ++PGDGIGP V +V++A+ + Y+V G +P + Sbjct: 7 IAVLPGDGIGPEVMAQASKVLDAVRQRFGLKISTSVYDVGGAAIDRHGSPLPAATVAGCE 66 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+++L GL P R + Sbjct: 67 QADAILFGSVGGPKWEHLPPAEQPERGALLPLRKHFKLFSNLRPARLYQGLEDFCPLRSD 126 Query: 543 ----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G E + + +V +F ERIA+ AFE A Sbjct: 127 IAARGFDILCVRELTGGIYFGQPKGREGQGMHERAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R KVT++ KAN+++ + L+ E +A YP + + + +DN MQL+ P QFDV++ Sbjct: 186 RRSKVTSIDKANVLQ-SSILWREVVNGIAADYPDVALSHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDLGGTS---TTQEVTDAVIAK 1220 A LS ++LR L AD +E A+ + +G YRT DL G T E+ D +IAK Sbjct: 300 AQILSLTLLLRFSLGKDDAADAIERAINQALEQG-YRTADLAGDGHAIGTHEMGD-IIAK 357
>Q5M405:LEU3_STRT2 3-isopropylmalate dehydrogenase - Streptococcus thermophilus (strain| ATCC BAA-250 / LMG 18311) Length = 345 Score = 107 bits (268), Expect = 1e-22 Identities = 98/353 (27%), Positives = 172/353 (48%), Gaps = 24/353 (6%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHG----------DMPSVPTEVIE 386 + + + GDGIGP + A V++ + + + F+ Y+V + +P +E Sbjct: 3 KKIVTLSGDGIGPEIMAAGLGVLDKVASKIEFD-YDVDAKPFGGAGIDAEGHPLPKATLE 61 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASL--VNCFNL-----PGLPT 533 + + L + P L +RKEL+L+A++ V F+ P P Sbjct: 62 AAKSADAILLAAIGGPKYDNAPVRPEQGLLAIRKELNLFANIRPVRIFDALKHLSPLKPE 121 Query: 534 RHENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKV 713 R E VD V+RE T G Y G EH + + + RI + AF+ A KKV Sbjct: 122 RIEGVDFVVVRELTGGIYFG-EHILEEDKARDINDYSADEIRRIMRRAFKIAQ-GRGKKV 179 Query: 714 TAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 893 T++ K N++ + L+ + EV+ ++P + +VD+ M ++ P +FDV+VT NL+ Sbjct: 180 TSIDKQNVLATSK-LWRKVADEVSLEFPDVTLEHQLVDSAAMIMITNPARFDVVVTENLF 238 Query: 894 GNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQ-GASAGNVGNDKILQQKKANPVALFLS 1067 G+++S+ ++ + ++ +++E SA ++ I ANP+++ LS Sbjct: 239 GDILSDESSVLPGTLGVMPSASHSENGPSLYEPIHGSAPDIAGQGI-----ANPISMILS 293 Query: 1068 SAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 AMMLR A+ +E+AV + +G TRDLGG ++T E+T A+I+ L Sbjct: 294 VAMMLRESFNETEGAELIENAVDKTLNQG-ILTRDLGGQASTAEMTAAIISNL 345
>Q5LZF3:LEU3_STRT1 3-isopropylmalate dehydrogenase - Streptococcus thermophilus (strain| CNRZ 1066) Length = 345 Score = 107 bits (268), Expect = 1e-22 Identities = 98/353 (27%), Positives = 172/353 (48%), Gaps = 24/353 (6%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHG----------DMPSVPTEVIE 386 + + + GDGIGP + A V++ + + + F+ Y+V + +P +E Sbjct: 3 KKIVTLSGDGIGPEIMAAGLGVLDKVASKIEFD-YDVDAKPFGGAGIDAEGHPLPKATLE 61 Query: 387 SIRRNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASL--VNCFNL-----PGLPT 533 + + L + P L +RKEL+L+A++ V F+ P P Sbjct: 62 AAKSADAILLAAIGGPKYDNAPVRPEQGLLAIRKELNLFANIRPVRIFDALKHLSPLKPE 121 Query: 534 RHENVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKV 713 R E VD V+RE T G Y G EH + + + RI + AF+ A KKV Sbjct: 122 RIEGVDFVVVRELTGGIYFG-EHILEEDKARDINDYSADEIRRIMRRAFKIAQ-GRGKKV 179 Query: 714 TAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 893 T++ K N++ + L+ + EV+ ++P + +VD+ M ++ P +FDV+VT NL+ Sbjct: 180 TSIDKQNVLATSK-LWRKVADEVSLEFPDVTLEHQLVDSAAMIMITNPARFDVVVTENLF 238 Query: 894 GNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQ-GASAGNVGNDKILQQKKANPVALFLS 1067 G+++S+ ++ + ++ +++E SA ++ I ANP+++ LS Sbjct: 239 GDILSDESSVLPGTLGVMPSASHSENGPSLYEPIHGSAPDIAGQGI-----ANPISMILS 293 Query: 1068 SAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 AMMLR A+ +E+AV + +G TRDLGG ++T E+T A+I+ L Sbjct: 294 VAMMLRESFNETEGAELIENAVDKTLNQG-ILTRDLGGQASTAEMTAAIISNL 345
>Q5HEE3:LEU3_STAAC 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain COL)| Length = 348 Score = 107 bits (268), Expect = 1e-22 Identities = 96/351 (27%), Positives = 157/351 (44%), Gaps = 23/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM--PSVPT-------EVIESIR 395 + +PGDGIGP + ++E + F H + S+ T + + + + Sbjct: 5 IVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLNACK 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGLPT-------RHE 542 R L G + P ++ L+LRK L+L+ ++ + G + R E Sbjct: 65 RADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFVNIRPTTVVKGASSLSPLKEERVE 124 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 D+ ++RE T G Y G T+ ERI AF+ A + R K+T+V Sbjct: 125 GTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLA-ASRRGKLTSV 183 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 K N++ + L+ + EV+ YP + N ++VD C M L+ P+QFDV+V NL+G++ Sbjct: 184 DKENVLA-SSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIVCENLFGDI 242 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQ--GASAGNVGNDKILQQKKANPVALFLSSAM 1076 +S+ A+ I D + SA ++ + ANP + LS AM Sbjct: 243 LSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNV-----ANPFGMILSLAM 297 Query: 1077 MLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 LR L P AD LE + +I G+ T DLGG T ++ + + KL+ Sbjct: 298 CLRESLNQPDAADELEQHIYSMIEHGQ-TTADLGGKLNTTDIFEILSQKLN 347
>Q2FF66:LEU3_STAA3 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain| USA300) Length = 348 Score = 107 bits (268), Expect = 1e-22 Identities = 96/351 (27%), Positives = 157/351 (44%), Gaps = 23/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM--PSVPT-------EVIESIR 395 + +PGDGIGP + ++E + F H + S+ T + + + + Sbjct: 5 IVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLNACK 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGLPT-------RHE 542 R L G + P ++ L+LRK L+L+ ++ + G + R E Sbjct: 65 RADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFVNIRPTTVVKGASSLSPLKEERVE 124 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 D+ ++RE T G Y G T+ ERI AF+ A + R K+T+V Sbjct: 125 GTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLA-ASRRGKLTSV 183 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 K N++ + L+ + EV+ YP + N ++VD C M L+ P+QFDV+V NL+G++ Sbjct: 184 DKENVLA-SSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIVCENLFGDI 242 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQ--GASAGNVGNDKILQQKKANPVALFLSSAM 1076 +S+ A+ I D + SA ++ + ANP + LS AM Sbjct: 243 LSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNV-----ANPFGMILSLAM 297 Query: 1077 MLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 LR L P AD LE + +I G+ T DLGG T ++ + + KL+ Sbjct: 298 CLRESLNQPDAADELEQHIYSMIEHGQ-TTADLGGKLNTTDIFEILSQKLN 347
>Q4ZUZ4:LEU3_PSEU2 3-isopropylmalate dehydrogenase - Pseudomonas syringae pv. syringae| (strain B728a) Length = 360 Score = 107 bits (268), Expect = 1e-22 Identities = 111/363 (30%), Positives = 173/363 (47%), Gaps = 34/363 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFE-TYEVHG----DMPSVPT--EVIES 389 + + ++PGDGIGP + +V+E + + FE T++V G D VP E +E Sbjct: 3 KQILILPGDGIGPEIMTEAVKVLELANEKYQLGFELTHDVIGGAAIDKHGVPLADETLER 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------P 530 R L G + P + L++R +L L+ +L P L P Sbjct: 63 ARAADAVLLGAVGGPKWDTIERDIRPERGLLKIRSQLGLFGNLRPAILYPQLADASSLKP 122 Query: 531 TRHENVDIAVIRENTEGEYSGLEHE---VVPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE T G Y G + G ++ + SE RIAK F+ A + Sbjct: 123 EIVAGLDIMIVRELTGGIYFGAPRGTRVLDNGERQAYDTLPYSESEIRRIAKVGFDMAMV 182 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V KAN++ + L+ E +VA YP ++ + + VDN MQLV P+QFDV+ Sbjct: 183 RG-KKLCSVDKANVLASSQ-LWREIVEQVARDYPEVELSHMYVDNAAMQLVRAPKQFDVI 240 Query: 876 VTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANP 1049 VT NL+G+++S+ A+ + + ++E SA ++ I ANP Sbjct: 241 VTDNLFGDILSDQASMLTGSIGMLPSASLDTANKGMYEPCHGSAPDIAGKGI-----ANP 295 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVI 1214 +A LS +MMLR+ AD +E AV V+ +G RT D+ TQE+ DAV+ Sbjct: 296 LATILSVSMMLRYSFNLTDAADAIEKAVSLVLDQG-IRTGDIWSEGKVKVGTQEMGDAVV 354 Query: 1215 AKL 1223 A L Sbjct: 355 AAL 357
>Q9JU79:LEU3_NEIMA 3-isopropylmalate dehydrogenase - Neisseria meningitidis serogroup A| Length = 356 Score = 107 bits (268), Expect = 1e-22 Identities = 105/361 (29%), Positives = 173/361 (47%), Gaps = 34/361 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM----------HAPVCFETYEVHGDMPSVPTEVIESI 392 + ++ GDGIGP + +V++ + +AP+ E Y+ +G P Sbjct: 5 IAILRGDGIGPEIVAETVRVLDKLIAQGLDVGYEYAPLGGEAYDEYGH--PYPEFTQNLC 62 Query: 393 RRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGLPTRHE---- 542 R+ L G + +P + L +RK+L+L+A+L P L Sbjct: 63 RKADAVLLGAVGSPQYDNLDRPLRPERGLLAIRKDLNLFANLRPAILYPELANASTLKSE 122 Query: 543 ---NVDIAVIRENTEGEYSGLEHEV---VPGVVESLKVMTKFCSE--RIAKYAFEYAYLN 698 +DI ++RE T Y G + G E M SE RIA AF+ A Sbjct: 123 IVAGLDILIVRELTGDIYFGEPRGIRVLENGEREGYNTMKYSESEIRRIAHVAFQSAQKR 182 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 + KKV +V KAN+++ + L+ E E+ +YP ++ + + VDN MQLV P+QFDV+ Sbjct: 183 S-KKVCSVGKANVLETTE-LWREIFEEIGKEYPDVELSHMYVDNAAMQLVRAPKQFDVIA 240 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQGASAGNVGNDKILQQKKANPVA 1055 T N++G+++S+ A+ + ++ ++E + I Q KANP+A Sbjct: 241 TGNIFGDILSDEASMLTGSIGMLPSASLDENGKGLYEPSHGSA----PDIAGQNKANPLA 296 Query: 1056 LFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTS--TTQEVTDAVIAK 1220 LS AM+LR+ L + A ++E+AV+ V+ +G RT D+ GT + E+ DAV+A Sbjct: 297 TVLSLAMLLRYSLNDEARAQQVENAVQKVLQQG-LRTGDIYEEGTKLVSCSEMGDAVLAT 355 Query: 1221 L 1223 L Sbjct: 356 L 356
>Q1RGC4:LEU3_ECOUT 3-isopropylmalate dehydrogenase - Escherichia coli (strain UTI89 /| UPEC) Length = 364 Score = 107 bits (268), Expect = 1e-22 Identities = 105/359 (29%), Positives = 164/359 (45%), Gaps = 33/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS---------VPTEVIESIR 395 + ++PGDGIGP V +V++A+ H D+ +P +E Sbjct: 8 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 67 Query: 396 RNKVCLKGGLATPVGGGVS-------SLNLQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+++L GL P R + Sbjct: 68 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 127 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVESL---KVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA+ AFE A Sbjct: 128 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 186 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R KVT++ KAN+++ + L+ E E+AT+YP ++ + +DN MQL+ P QFDV++ Sbjct: 187 RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 245 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 246 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 300 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVIAK 1220 A LS A++LR+ L A +E A+ + EG RT DL G + + + +IA+ Sbjct: 301 AQILSLALLLRYSLDADDAASAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIAR 358
>Q66EM2:LEU3_YERPS 3-isopropylmalate dehydrogenase - Yersinia pseudotuberculosis| Length = 363 Score = 107 bits (267), Expect = 1e-22 Identities = 106/360 (29%), Positives = 163/360 (45%), Gaps = 34/360 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHA----PVCFETYEVHGDM-----PSVPTEVIESIR 395 + ++PGDGIGP V +V++A+ + Y+V G +P + Sbjct: 7 IAVLPGDGIGPEVMAQASKVLDAVRQRFGLKISTSVYDVGGAAIDRHGSPLPAATVAGCE 66 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+++L GL P R + Sbjct: 67 QADAILFGSVGGPKWEHLPPAEQPERGALLPLRKHFKLFSNLRPARLYQGLEDFCPLRSD 126 Query: 543 ----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G E + + +V +F ERIA+ AFE A Sbjct: 127 IAARGFDILCVRELTGGIYFGQPKGREGQGMHERAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R KVT++ KAN+++ + L+ E +A YP + + + +DN MQL+ P QFDV++ Sbjct: 186 RRSKVTSIDKANVLQ-SSILWREVVNGIAADYPDVALSHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDLGGTS---TTQEVTDAVIAK 1220 A LS ++LR L AD +E A+ + +G YRT DL G T E+ D +IAK Sbjct: 300 AQILSLILLLRFSLGKDDAADAIERAINQALEQG-YRTADLAGDGHAIGTHEMGD-IIAK 357
>Q1LKH7:LEU3_RALME 3-isopropylmalate dehydrogenase - Ralstonia metallidurans (strain| CH34 / ATCC 43123 / DSM 2839) Length = 355 Score = 107 bits (267), Expect = 1e-22 Identities = 107/363 (29%), Positives = 168/363 (46%), Gaps = 36/363 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMH-------APVCFETYEVHGDMPSVPTEVIESIRRN 401 + ++PGDGIGP + +V+ A+ APV YE G +P ++ + Sbjct: 3 IAVLPGDGIGPEIVAEAVKVLNALDEKFEMETAPVGGAGYEAEGH--PLPDNTLKLAKEA 60 Query: 402 KVCLKGGLATPVGGGVS------SLNLQLRKELDLYASLVNCFNLPGL-------PTRHE 542 L G + + L LRK L L+A+ P L P Sbjct: 61 DAILFGAVGDWKYDSLDRPLRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA 120 Query: 543 NVDIAVIRENTEGEYSGLEHEV-------VPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE Y G V G E M E RIA AF+ A Sbjct: 121 GLDILIVRELNGDIYFGQPRGVREAPDGLFKGAREGFDTMRYSEPEVRRIAHVAFQAA-A 179 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V KAN+++ + + +V+ +YP ++ + + VDN MQLV P+ FDV+ Sbjct: 180 KRGKKLCSVDKANVLETFQ-FWKDIVIDVSKEYPDVELSHMYVDNAAMQLVKAPKSFDVI 238 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQG-ASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ AA + ++ ++E SA ++ + ANP Sbjct: 239 VTGNMFGDILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGV-----ANP 293 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVI 1214 +A LS+AMMLR+ L ADR+E+AVK V+A+G YRT D+ T+E+ +AV+ Sbjct: 294 LATILSAAMMLRYSLNRAEQADRIENAVKKVLAQG-YRTADIVTPGCKQVGTREMGEAVL 352 Query: 1215 AKL 1223 A L Sbjct: 353 AAL 355
>Q51375:LEU3_PSEAE 3-isopropylmalate dehydrogenase - Pseudomonas aeruginosa| Length = 360 Score = 107 bits (267), Expect = 1e-22 Identities = 108/363 (29%), Positives = 176/363 (48%), Gaps = 34/363 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHA--PVCFETYE--VHG---DMPSVPT--EVIES 389 + + ++PGDGIGP + +V+E + + FE E + G D VP + ++ Sbjct: 3 KQILVLPGDGIGPEIMAEAVKVLELANDRFQLGFELAEDVIGGAAIDKHGVPLADQTLQR 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------P 530 R+ L G + P + L++R +L L+A+L P L P Sbjct: 63 ARQADAVLLGAVGGPKWDRIERDIRPERGLLKIRSQLGLFANLRPAILYPQLAAASSLKP 122 Query: 531 TRHENVDIAVIRENTEGEYSGLEHE---VVPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE T G Y G E + G ++ + SE RIA+ F+ A + Sbjct: 123 EVVAGLDILIVRELTGGIYFGQPREQRVLENGERQAYDTLPYSESEIRRIARVGFDMARV 182 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 N + + +V KAN++ + L+ E EVA YP ++ + + VDN MQLV P+QFDVM Sbjct: 183 RNNR-LCSVDKANVLASSQ-LWREVVEEVAKDYPDVELSHMYVDNAAMQLVRAPKQFDVM 240 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQ-GASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ A+ + ++ ++E SA ++ I ANP Sbjct: 241 VTDNMFGDILSDEASMLTGSIGMLPSASLDANNKGMYEPCHGSAPDIAGQGI-----ANP 295 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVI 1214 +A LS +MMLR+ + AD +E AV V+ +G RT D+ T+E+ DAV+ Sbjct: 296 LATILSVSMMLRYSFSQATAADAIEQAVSKVLDQG-LRTGDIWSEGCRKVGTREMGDAVV 354 Query: 1215 AKL 1223 A L Sbjct: 355 AAL 357
>Q2FWK2:LEU3_STAA8 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain NCTC| 8325) Length = 348 Score = 107 bits (266), Expect = 2e-22 Identities = 96/351 (27%), Positives = 156/351 (44%), Gaps = 23/351 (6%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDM--PSVPT-------EVIESIR 395 + +PGDGIGP + ++E + F H + S+ T + + + + Sbjct: 5 IVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLNACK 64 Query: 396 RNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASLVNCFNLPGLPT-------RHE 542 R L G + P ++ L+LRK L+L+ ++ + G + R E Sbjct: 65 RADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFVNIRPTTVVKGASSLSPLKEERVE 124 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 D+ ++RE T G Y G T+ ERI AF+ A + R K+T+V Sbjct: 125 GTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLA-ASRRGKLTSV 183 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 K N++ + L+ + EV+ YP + N + VD C M L+ P+QFDV+V NL+G++ Sbjct: 184 DKENVLA-SSKLWRKVVNEVSQLYPEVTVNHLFVDACSMHLITNPKQFDVIVCENLFGDI 242 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQ--GASAGNVGNDKILQQKKANPVALFLSSAM 1076 +S+ A+ I D + SA ++ + ANP + LS AM Sbjct: 243 LSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNV-----ANPFGMILSLAM 297 Query: 1077 MLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 LR L P AD LE + +I G+ T DLGG T ++ + + KL+ Sbjct: 298 CLRESLNQPDAADELEQHIYSMIEHGQ-TTADLGGKLNTTDIFEILSQKLN 347
>Q83SP1:LEU3_SHIFL 3-isopropylmalate dehydrogenase - Shigella flexneri| Length = 363 Score = 107 bits (266), Expect = 2e-22 Identities = 105/359 (29%), Positives = 163/359 (45%), Gaps = 33/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS---------VPTEVIESIR 395 + ++PGDGIGP V +V+ A+ H D+ +P +E Sbjct: 7 IAVLPGDGIGPEVMTQALKVLNAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 Query: 396 RNKVCLKGGLATPVGGGVS-------SLNLQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+++L GL P R + Sbjct: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVESL---KVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA+ AFE A Sbjct: 127 IAANGFDIQCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R KVT++ KAN+++ + L+ E E+AT+YP ++ + +DN MQL+ P QFDV++ Sbjct: 186 RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVIAK 1220 A LS A++LR+ L A +E A+ + EG RT DL G + + + +IA+ Sbjct: 300 AQILSLALLLRYSLDADDAASAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIAR 357
>Q5PDG2:LEU3_SALPA 3-isopropylmalate dehydrogenase - Salmonella paratyphi-a| Length = 363 Score = 107 bits (266), Expect = 2e-22 Identities = 106/359 (29%), Positives = 167/359 (46%), Gaps = 33/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP----VCFETYEVHGDMPS-----VPTEVIESIR 395 + ++PGDGIGP V +VM+A+ + + Y+V G +P +E Sbjct: 7 IAVLPGDGIGPEVMAQALKVMDAVRSRFDMRITTSRYDVGGIAIDNHGHPLPKATVEGCE 66 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + + L LRK L+++L GL P R + Sbjct: 67 QADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVESL---KVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA+ AFE A Sbjct: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R+KVT++ KAN+++ + L+ E +VA YP ++ + +DN MQL+ P QFDV++ Sbjct: 186 RRRKVTSIDKANVLQ-SSILWREIVNDVAKTYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVIAK 1220 A LS A++LR+ L A +E A+ + EG RT DL G + + + +IA+ Sbjct: 300 AQILSLALLLRYSLDANDAATAIEQAINRALEEG-VRTGDLARGAAAVSTDEMGDIIAR 357
>Q7UIE1:LEU3_RHOBA 3-isopropylmalate dehydrogenase - Rhodopirellula baltica| Length = 359 Score = 107 bits (266), Expect = 2e-22 Identities = 105/361 (29%), Positives = 175/361 (48%), Gaps = 33/361 (9%) Frame = +3 Query: 240 TVTLIPGDGIGPLVTGAVRQVM----EAMHAPVCFETYEVHGDM-----PSVPTEVIESI 392 ++ L+PGDGIGP + R V+ E F ++++ G +P I++ Sbjct: 4 SIVLLPGDGIGPEIVEQARLVLVKVAERFGHTFDFSSHQIGGIAIDETGDPLPQPTIDAC 63 Query: 393 RRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASL--VNCFN--LPGLPTRHE 542 R L G + P S+ L++RKEL L+A+L + F+ P R + Sbjct: 64 RNAAAILLGAVGGPKWDDPSAKTRPEAGLLKIRKELGLFANLRPIKLFDELADASPLRAD 123 Query: 543 NV---DIAVIRENTEGEYSGLEHEVVPGVVES-LKVMTKFCSE--RIAKYAFEYAYLNNR 704 V DI RE T G Y G G E+ + MT E RI + A + A Sbjct: 124 IVKGTDILFFRELTGGIYFGESGTSGSGEEETAFQSMTYSVGEVKRIVRMAAQAAR-GRS 182 Query: 705 KKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTP 884 ++T+V KAN+++ + + +A ++P +QY+ ++VD+ M L+ +P +FDV+VT Sbjct: 183 NRLTSVDKANVLEPSRLWRRVAAEVMANEFPDVQYDVVLVDSMAMHLINRPSEFDVVVTG 242 Query: 885 NLYGNLVSNVAAGIAXXXXXXXXXXXXQ-DHAVFEQ-GASAGNVGNDKILQQKKANPVAL 1058 N++G+++++ A+ + ++E SA ++ + ANP+A Sbjct: 243 NMFGDILTDEASMLPGSLGMLPSASLGDGGPGLYEPIHGSAPDIAGKSV-----ANPLAT 297 Query: 1059 FLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL-----GGTSTTQEVTDAVIAK 1220 L++AMMLRH L A+ +E AV GVI +G RT DL + +T+E+ AV+AK Sbjct: 298 ILAAAMMLRHSLGLTDEAEAIEKAVAGVITDG-LRTPDLARGDQSKSVSTEEMGAAVVAK 356 Query: 1221 L 1223 L Sbjct: 357 L 357
>Q48K97:LEU3_PSE14 3-isopropylmalate dehydrogenase - Pseudomonas syringae pv.| phaseolicola (strain 1448A / Race 6) Length = 360 Score = 107 bits (266), Expect = 2e-22 Identities = 110/363 (30%), Positives = 173/363 (47%), Gaps = 34/363 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFE-TYEVHG----DMPSVPT--EVIES 389 + + ++PGDGIGP + +V+E + + FE T++V G D VP E ++ Sbjct: 3 KQILILPGDGIGPEIMTEAVKVLELANEKYQLGFELTHDVIGGAAIDKHGVPLADETLDR 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------P 530 R L G + P + L++R +L L+ +L P L P Sbjct: 63 ARAADAVLLGAVGGPKWDTIERDIRPERGLLKIRSQLGLFGNLRPAILYPQLADASSLKP 122 Query: 531 TRHENVDIAVIRENTEGEYSGLEHE---VVPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE T G Y G + G ++ + SE RIAK F+ A + Sbjct: 123 EIVAGLDILIVRELTGGIYFGAPRGTRVLDNGERQAYDTLPYSESEIRRIAKVGFDMAMV 182 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V KAN++ + L+ E +VA YP ++ + + VDN MQLV P+QFDV+ Sbjct: 183 RG-KKLCSVDKANVLASSQ-LWREIVEQVAKDYPEVELSHMYVDNAAMQLVRAPKQFDVI 240 Query: 876 VTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANP 1049 VT NL+G+++S+ A+ + + ++E SA ++ I ANP Sbjct: 241 VTDNLFGDILSDQASMLTGSIGMLPSASLDTANKGMYEPCHGSAPDIAGKGI-----ANP 295 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVI 1214 +A LS +MMLR+ AD +E AV V+ +G RT D+ TQE+ DAV+ Sbjct: 296 LATILSVSMMLRYSFNLTDAADAIEKAVSVVLDQG-IRTGDIWSEGKVKVGTQEMGDAVV 354 Query: 1215 AKL 1223 A L Sbjct: 355 AAL 357
>Q5F8T6:LEU3_NEIG1 3-isopropylmalate dehydrogenase - Neisseria gonorrhoeae (strain ATCC| 700825 / FA 1090) Length = 356 Score = 107 bits (266), Expect = 2e-22 Identities = 105/361 (29%), Positives = 173/361 (47%), Gaps = 34/361 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM----------HAPVCFETYEVHGDMPSVPTEVIESI 392 + ++ GDGIGP + +V++ +AP+ E Y+ +G P Sbjct: 5 IAILRGDGIGPEIVAETVRVLDKFIAQGLDADYEYAPLGGEAYDEYGH--PYPEFTQNLC 62 Query: 393 RRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------PT 533 R+ L G + +P + L +RK+L+L+A+L P L P Sbjct: 63 RKADAVLLGAVGSPQYDNLDRPLRPERGLLAIRKDLNLFANLRPAVLYPELANASTLKPE 122 Query: 534 RHENVDIAVIRENTEGEYSGLEHEV---VPGVVESLKVMTKFCSE--RIAKYAFEYAYLN 698 +DI ++RE T Y G + G E M SE RIA AF+ A Sbjct: 123 IVAGLDILIVRELTGDIYFGEPRGIRVLENGEHEGYNTMKYSESEIRRIAHVAFQSAQKR 182 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 + KKV +V KAN+++ + L+ E E+ +YP ++ + + VDN MQLV P+QFDV+ Sbjct: 183 S-KKVCSVGKANVLETTE-LWREIFEEIGKQYPDVELSHMYVDNAAMQLVRAPKQFDVIA 240 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQD-HAVFEQGASAGNVGNDKILQQKKANPVA 1055 T N++G+++S+ A+ + ++ ++E + I Q KANP+A Sbjct: 241 TGNIFGDILSDEASMLTGSIGMLPSASLDENGKGLYEPSHGSA----PDIAGQNKANPLA 296 Query: 1056 LFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTS--TTQEVTDAVIAK 1220 LS AM+LR+ L + A ++E++V+ V+ +G RT D+ GT + E+ DAV+A Sbjct: 297 TILSLAMLLRYSLNDEARAQQVENSVQKVLQQG-LRTGDIYEEGTKLVSCSEMGDAVLAA 355 Query: 1221 L 1223 L Sbjct: 356 L 356
>P05644:LEU3_BACCA 3-isopropylmalate dehydrogenase - Bacillus caldotenax| Length = 366 Score = 107 bits (266), Expect = 2e-22 Identities = 99/311 (31%), Positives = 148/311 (47%), Gaps = 30/311 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFE-TYE--------VHGDMPSVPTEVIESIR 395 + ++PGDGIG VT +V++A+ E T+E + +P E + R Sbjct: 6 IAVLPGDGIGKEVTSGAVEVLKAVGIRFGHEFTFEYGLIGGAAIDEAGTPLPEETVRLCR 65 Query: 396 RNKVCLKGGLATPVGGGVSSLN----------LQLRKELDLYASL--VNCFNL-----PG 524 + L G VGG N L +RK+LDLYA+L V C++ P Sbjct: 66 ESDAVLLGA----VGGPKWDDNPPHLRPEKGLLAIRKQLDLYANLRPVVCYDSLVSRSPL 121 Query: 525 LPTRHENVDIAVIRENTEGEYSGLEHEVVPG----VVESLKVMTKFCSERIAKYAFEYAY 692 P + VD ++RE T G Y G VV V++L + K ERI + AFE A Sbjct: 122 KPDLVQGVDFVIVRELTGGIYFGQPSAVVENGEEKAVDTL-LYKKEEIERIVRMAFELAR 180 Query: 693 LNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDV 872 RKKVT+V KAN++ + L+ E EVA ++P + ++VD MQL+ P+QFDV Sbjct: 181 -GRRKKVTSVDKANVLS-SSRLWREVAEEVANEFPDVTLEHMLVD-MRMQLIRAPKQFDV 237 Query: 873 MVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDKILQQKKANPV 1052 +VT N++G+++S+ A+ ++ + I KANP+ Sbjct: 238 IVTENMFGDILSDEASMLSGSLGMLPSASLSASGPSLYEPVHG---SAPDIAGMNKANPI 294 Query: 1053 ALFLSSAMMLR 1085 A LS+AMMLR Sbjct: 295 AAILSAAMMLR 305
>Q81T67:LEU3_BACAN 3-isopropylmalate dehydrogenase - Bacillus anthracis| Length = 354 Score = 107 bits (266), Expect = 2e-22 Identities = 98/352 (27%), Positives = 161/352 (45%), Gaps = 22/352 (6%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVC--FETYEVHGDMPSV-------PTEVIES 389 + + + GDG+GP V + ++V+ + F + H ++ P + + Sbjct: 3 KRIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAA 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASL----VNCFNLPGLPTRH-E 542 + L G + P G L LRK L ++A++ V P + + Sbjct: 63 CLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKKAD 122 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 +D V+RE T G Y E V + ERI AF+ A +KKVT++ Sbjct: 123 EIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSCAFQLAS-KRKKKVTSI 181 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 KAN+++ + L+ EVA +YP ++ I+VD M+L+ P +FDV+VT NL+G++ Sbjct: 182 DKANVLE-SSKLWRIVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFGDI 240 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAG---NVGNDKILQQKKANPVALFLSSA 1073 +S+ A+ +A HA E+G S + I + KANP+A+ S A Sbjct: 241 LSDEASVLA----GSLGMLPSASHA--EKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVA 294 Query: 1074 MML-RHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 MML + +E A+ V+ GK T D+GGT TT T AV+ +++ Sbjct: 295 MMLGQSFGLTREGCAIEEAISAVLKSGKC-TADIGGTETTTSFTKAVMQEME 345
>Q46YW0:LEU3_RALEJ 3-isopropylmalate dehydrogenase - Ralstonia eutropha (strain JMP134)| (Alcaligenes eutrophus) Length = 355 Score = 106 bits (265), Expect = 2e-22 Identities = 107/363 (29%), Positives = 168/363 (46%), Gaps = 36/363 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMH-------APVCFETYEVHGDMPSVPTEVIESIRRN 401 + ++PGDGIGP + +V+ A+ APV YE G +P ++ + Sbjct: 3 IAVLPGDGIGPEIVAEAVKVLNALDEKFEMETAPVGGAGYEAEGH--PLPENTLKLAKEA 60 Query: 402 KVCLKGGLATPVGGGVS------SLNLQLRKELDLYASLVNCFNLPGL-------PTRHE 542 L G + + L LRK L L+A+ P L P Sbjct: 61 DAILFGAVGDWKYDSLERALRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPELVA 120 Query: 543 NVDIAVIRENTEGEYSGLEHEV-------VPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE Y G V G E M E RIA AF+ A Sbjct: 121 GLDILIVRELNGDIYFGQPRGVREAPDGLFKGAREGFDTMRYSEPEIRRIAHVAFQAA-A 179 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V KAN+++ + + +V+ +YP ++ + + VDN MQLV P+ FDV+ Sbjct: 180 KRGKKLCSVDKANVLETFQ-FWKDIVIDVSKEYPDVELSHMYVDNAAMQLVKAPKSFDVI 238 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQG-ASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ AA + ++ ++E SA ++ + ANP Sbjct: 239 VTGNMFGDILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGV-----ANP 293 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVI 1214 +A LS+AMMLR+ L ADR+E+AVK V+A+G YRT D+ T+E+ +AV+ Sbjct: 294 LATILSAAMMLRYSLNKAEQADRIENAVKKVLAQG-YRTGDILTPGCKQVGTREMGEAVL 352 Query: 1215 AKL 1223 A L Sbjct: 353 AAL 355
>P30125:LEU3_ECOLI 3-isopropylmalate dehydrogenase - Escherichia coli| Length = 363 Score = 106 bits (265), Expect = 2e-22 Identities = 105/359 (29%), Positives = 164/359 (45%), Gaps = 33/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS---------VPTEVIESIR 395 + ++PGDGIGP V +V++A+ H D+ +P +E Sbjct: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 Query: 396 RNKVCLKGGLATPVGGGVS-------SLNLQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+++L GL P R + Sbjct: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVESL---KVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA+ AFE A Sbjct: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R KVT++ KAN+++ + L+ E E+AT+YP ++ + +DN MQL+ P QFDV++ Sbjct: 186 RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVIAK 1220 A LS A++LR+ L A +E A+ + EG RT DL G + + + +IA+ Sbjct: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIAR 357
>Q2IJK7:LEU3_ANADE 3-isopropylmalate dehydrogenase - Anaeromyxobacter dehalogenans| (strain 2CP-C) Length = 353 Score = 106 bits (265), Expect = 2e-22 Identities = 106/358 (29%), Positives = 168/358 (46%), Gaps = 31/358 (8%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-----HAPVCFE------TYEVHGDMPSVPTEVIES 389 + ++PGDGIGP VT +V+EA+ HA E + + HG ++ EV+ Sbjct: 5 IVVLPGDGIGPEVTAEAVRVLEAVARRGGHALSFTERLMGGCSIDAHG--TALTPEVLAD 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSL------NLQLRKELDLYASLVNCFNLPGL-------P 530 + L G + P + L LRK L ++A+L P L P Sbjct: 63 CQAADAVLLGAVGGPKWDDPRAKVRPEQGLLGLRKGLGVFANLRPVRVHPSLLDSSPLRP 122 Query: 531 TRHENVDIAVIRENTEGEYSGLE--HEVVPGVVESLKVM--TKFCSERIAKYAFEYAYLN 698 + VDI VIRE T G Y G +V G ++ + F R+ + AF A Sbjct: 123 EKLRGVDIMVIRELTGGLYFGQPKGRDVKDGHARAVDTLEYQDFEVRRVVELAFRIA-KG 181 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 +KKVT+V KAN+++ + L+ E + P + + ++VD M+LV P DV+V Sbjct: 182 RKKKVTSVDKANVLE-SSRLWRELATAIGQANPDVALDHMLVDTAAMRLVTSPATLDVVV 240 Query: 879 TPNLYGNLVSNVAAGIA-XXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANPV 1052 T N++G+++++ A+ +A Q ++E SA ++ I ANPV Sbjct: 241 TENMFGDILTDEASVLAGSMGMLPSASIGEQGPGLYEPIHGSAPDIAGKGI-----ANPV 295 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKL 1223 LS+A++LRH L A +E AV I +G RT DLGG +T+ + D ++ +L Sbjct: 296 GTVLSAALLLRHSLGLEPEAAAIERAVDQTITDG-CRTADLGGKLSTRAMADEILKRL 352
>Q3BPJ8:LEU3_XANC5 3-isopropylmalate dehydrogenase - Xanthomonas campestris pv.| vesicatoria (strain 85-10) Length = 357 Score = 106 bits (264), Expect = 3e-22 Identities = 112/365 (30%), Positives = 171/365 (46%), Gaps = 36/365 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFE---------TYEVHGDMPSVPTEVI 383 + + ++PGDGIGP + +V++ + A + FE Y+ +G + E + Sbjct: 3 KQILILPGDGIGPEIMAEAVKVLKRIDAQHGLGFELVYDELGGAAYDKYGS--PLADETL 60 Query: 384 ESIRRNKVCLKGGLATPVGGGVS-SLN-----LQLRKELDLYASLVNCFNLPGL------ 527 E R L G + P + SL L++R +L L+A+L P L Sbjct: 61 ERARAADAVLLGAVGGPQWDTIDPSLRPERGLLKIRSQLGLFANLRPALLYPQLADASTL 120 Query: 528 -PTRHENVDIAVIRENTEGEYSGL---EHEVVPGVVESLKVMTKFCSE--RIAKYAFEYA 689 P +D+ ++RE T G Y G + G ++ + SE RIAK FE A Sbjct: 121 KPEVVAGLDLLILRELTGGIYFGQPRGNRTLDNGERQAYDTLPYSESEIRRIAKAGFEMA 180 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD 869 L KK+ +V KAN++ + L+ EVA YP I + + VDN MQLV P+QFD Sbjct: 181 RLRG-KKLCSVDKANVLASSQ-LWRAVVEEVAKDYPDIALSHMYVDNAAMQLVRAPKQFD 238 Query: 870 VMVTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKA 1043 V+VT N++G+++S+ A+ + ++E SA ++ I A Sbjct: 239 VIVTDNMFGDILSDQASMLTGSIGMLPSASLDANSKGMYEPCHGSAPDIAGKGI-----A 293 Query: 1044 NPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVT----DA 1208 NP+A LS AMMLR+ AD +E AV V+ +G RT D+ TT+ T DA Sbjct: 294 NPLATILSVAMMLRYTFAQADAADAIERAVGKVLDQG-LRTADIWSEGTTKVGTVAMGDA 352 Query: 1209 VIAKL 1223 V+A L Sbjct: 353 VVAAL 357
>Q884C0:LEU3_PSESM 3-isopropylmalate dehydrogenase - Pseudomonas syringae pv. tomato| Length = 360 Score = 106 bits (264), Expect = 3e-22 Identities = 109/363 (30%), Positives = 174/363 (47%), Gaps = 34/363 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFE-TYEVHG----DMPSVPT--EVIES 389 + + ++PGDGIGP + +V+E + + FE T++V G D VP E ++ Sbjct: 3 KQILILPGDGIGPEIMTEAVKVLELANQKYQLGFELTHDVIGGAAIDKHGVPLADETLDR 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------P 530 R L G + P + L++R +L L+ +L P L P Sbjct: 63 ARAADAVLLGAVGGPKWDTIERDIRPERGLLKIRSQLGLFGNLRPAILYPQLADASSLKP 122 Query: 531 TRHENVDIAVIRENTEGEYSGLEHE---VVPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE T G Y G + G ++ + SE RIAK F+ A + Sbjct: 123 EIVAGLDILIVRELTGGIYFGAPRGTRVLDNGERQAYDTLPYSESEIRRIAKVGFDMAMV 182 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V KAN++ + L+ E +VA YP ++ + + VDN MQLV P+QFDV+ Sbjct: 183 RG-KKLCSVDKANVLASSQ-LWREIVEQVAKDYPEVELSHLYVDNAAMQLVRAPKQFDVI 240 Query: 876 VTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANP 1049 VT NL+G+++S+ A+ + + ++E SA ++ I ANP Sbjct: 241 VTDNLFGDILSDQASMLTGSIGMLPSASLDTANKGMYEPCHGSAPDIAGQGI-----ANP 295 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST----TQEVTDAVI 1214 +A LS +MMLR+ + AD +E AV V+ +G RT D+ T+E+ DAV+ Sbjct: 296 LATILSVSMMLRYSFNLTAAADAIEQAVSLVLDQG-IRTGDIWSEGKVKVGTKEMGDAVV 354 Query: 1215 AKL 1223 A L Sbjct: 355 AAL 357
>Q2VZV2:LEU3_MAGMM 3-isopropylmalate dehydrogenase - Magnetospirillum magneticum (strain| AMB-1 / ATCC 700264) Length = 369 Score = 106 bits (264), Expect = 3e-22 Identities = 107/374 (28%), Positives = 173/374 (46%), Gaps = 42/374 (11%) Frame = +3 Query: 231 APRTVTLIPGDGIGPLVTGAVRQVMEAM--HAPVCFE---------TYEVHGDMPSVPTE 377 A + + ++PGDGIG V VR++++ M + FE Y+VHG P E Sbjct: 2 AAKKLLILPGDGIGVEVMAQVRRIIDWMGRKRKIEFEITEGLLGGAAYDVHGT--PYPAE 59 Query: 378 VIESIRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGLPTRH 539 +E+ L G + P + L +RK++ L+A+L L L Sbjct: 60 TLEAALAADAVLLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADAS 119 Query: 540 -------ENVDIAVIRENTEGEYSGLEH--EVVPGVVE---SLKVMTKFCSERIAKYAFE 683 +DI ++RE T G Y G + +P + V T +RI + AF+ Sbjct: 120 TLKAEVVSGLDIMILRELTGGLYFGQPRGIDTLPDGTRKGYNTLVYTTPEIQRIGRVAFD 179 Query: 684 YAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQ 863 A N KK+ +V KAN+++ E + ++P ++ + VDN MQLV P+Q Sbjct: 180 LARKRN-KKLCSVDKANVLECTVLWREEMIKLQKEEFPDVELTHMYVDNAAMQLVRNPKQ 238 Query: 864 FDVMVTPNLYGNLVSNVAA------GIAXXXXXXXXXXXXQDHAVFE--QGASAGNVGND 1019 FDVMVT N++G+++S+ AA G+ + A++E G++ G D Sbjct: 239 FDVMVTENMFGDILSDCAAMLTGSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIAGKD 298 Query: 1020 KILQQKKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL----GGTS 1184 ANP+A +S AM LR+ + AD +E+AVK V+ +G RT D+ Sbjct: 299 ------MANPLATIMSFAMCLRYSFDMAAEADLIETAVKNVL-KGGLRTADIMQPGKAKV 351 Query: 1185 TTQEVTDAVIAKLD 1226 +T + +AV+ +LD Sbjct: 352 STTVMGEAVVRELD 365
>Q6HLF2:LEU3_BACHK 3-isopropylmalate dehydrogenase - Bacillus thuringiensis subsp.| konkukian Length = 354 Score = 106 bits (264), Expect = 3e-22 Identities = 97/352 (27%), Positives = 160/352 (45%), Gaps = 22/352 (6%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVC--FETYEVHGDMPSV-------PTEVIES 389 + + + GDG+GP V + + V+ + F + H ++ P + + Sbjct: 3 KRIVCLAGDGVGPEVMESAKGVLHMVERLYGHHFHLQDEHFGGVAIDLTGQPLPQRTLAA 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN----LQLRKELDLYASL----VNCFNLPGLPTRH-E 542 + L G + P G L LRK L ++A++ V P + + Sbjct: 63 CLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKKAD 122 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLNNRKKVTAV 722 +D V+RE T G Y + V + ERI YAF+ A +KKVT++ Sbjct: 123 EIDFVVVRELTGGIYFSYPKKRTDEVATDTLTYHRHEIERIVSYAFQLAS-KRKKKVTSI 181 Query: 723 HKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNL 902 KAN+++ + L+ EVA +YP ++ I+VD M+L+ P +FDV+VT NL+G++ Sbjct: 182 DKANVLE-SSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFDVIVTENLFGDI 240 Query: 903 VSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAG---NVGNDKILQQKKANPVALFLSSA 1073 +S+ A+ +A HA E+G S + I + KANP+A+ S A Sbjct: 241 LSDEASVLA----GSLGMLPSASHA--EKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVA 294 Query: 1074 MML-RHLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTDAVIAKLD 1226 MML + +E A+ V+ GK T D+GG TT T AV+ +++ Sbjct: 295 MMLGQSFGLTREGCAIEEAISAVLKSGKC-TADIGGAETTTSFTKAVMQEME 345
>Q3Z5T7:LEU3_SHISS 3-isopropylmalate dehydrogenase - Shigella sonnei (strain Ss046)| Length = 363 Score = 105 bits (263), Expect = 4e-22 Identities = 105/359 (29%), Positives = 163/359 (45%), Gaps = 33/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS---------VPTEVIESIR 395 + ++PGDGIGP V +V+ A+ H D+ +P +E Sbjct: 7 IAVLPGDGIGPEVMTQALKVLNAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 Query: 396 RNKVCLKGGLATPVGGGVS-------SLNLQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+++L GL P R + Sbjct: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKRFKLFSNLRPAKLYQGLEAFCPLRAD 126 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVESL---KVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA+ AFE A Sbjct: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R KVT++ KAN+++ + L+ E E+AT+YP ++ + +DN MQL+ P QFDV++ Sbjct: 186 RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVIAK 1220 A LS A++LR+ L A +E A+ + EG RT DL G + + + +IA+ Sbjct: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIAR 357
>Q326G2:LEU3_SHIBS 3-isopropylmalate dehydrogenase - Shigella boydii serotype 4 (strain| Sb227) Length = 363 Score = 105 bits (263), Expect = 4e-22 Identities = 105/359 (29%), Positives = 164/359 (45%), Gaps = 33/359 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS---------VPTEVIESIR 395 + ++PGDGIGP V +V++A+ H D+ +P +E Sbjct: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 Query: 396 RNKVCLKGGLATPVGGGVS-------SLNLQLRKELDLYASLVNCFNLPGL----PTRHE 542 + L G + P + L LRK L+++L GL P R + Sbjct: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 Query: 543 ----NVDIAVIRENTEGEYSGL-EHEVVPGVVESL---KVMTKFCSERIAKYAFEYAYLN 698 DI +RE T G Y G + G E +V +F ERIA+ AFE A Sbjct: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 185 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R KVT++ KAN+++ + L+ E E+AT+YP ++ + +DN MQL+ P QFDV++ Sbjct: 186 RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANPV 1052 NL+G+++S+ A I Q ++E G SA ++ I ANP+ Sbjct: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDITGKNI-----ANPI 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL--GGTSTTQEVTDAVIAK 1220 A LS A++LR+ L A +E A+ + EG RT DL G + + + +IA+ Sbjct: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIAR 357
>Q98E57:LEU3_RHILO 3-isopropylmalate dehydrogenase - Rhizobium loti (Mesorhizobium loti)| Length = 367 Score = 105 bits (262), Expect = 5e-22 Identities = 110/375 (29%), Positives = 181/375 (48%), Gaps = 45/375 (12%) Frame = +3 Query: 231 APRTVTLIPGDGIGPLVTGAVRQVMEAMHAPVC--FET---------YEVHGDMPSVPTE 377 A + + L+PGDGIGP V++++ AM+ + F T Y+ HG S + Sbjct: 2 ATKHLFLLPGDGIGPEAMAEVKKLISAMNEKLGSGFATDEGLVGGCAYDAHGAAIS-DAD 60 Query: 378 VIESIRRNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGLPTRH 539 + +++ + V L G + P V + L+LRK+++L+A+L P L Sbjct: 61 MAKAMAADAV-LFGAVGGPKWDAVPYEVRPEAGLLRLRKDMELFANLRPAICYPALAASS 119 Query: 540 -------ENVDIAVIRENTEGEYSGLEHEVVP-------GVVESLKVMTKFCSERIAKYA 677 E +DI ++RE T G Y G +++ G+ +V F ERI+ A Sbjct: 120 SLKQEVVEGLDILIVRELTGGVYFGEPKQIIDLGNGQKRGI--DTQVYDTFEIERISGVA 177 Query: 678 FEYAYLNNRKKVTAVHKANIMKLADGLFLESCREV-ATKYPGIQYNEIIVDNCCMQLVAK 854 FE A + VT++ K N+MK + L+ E + +Y ++ + ++ D MQLV Sbjct: 178 FELAR-TRKNHVTSMEKRNVMK-SGVLWNEVVTQTHKARYADVKLDHMLADAGGMQLVRW 235 Query: 855 PEQFDVMVTPNLYGNLVSNVAAGIA-------XXXXXXXXXXXXQDHAVFEQ-GASAGNV 1010 P+QFDV+VT NL+G+++S++AA + + A++E SA ++ Sbjct: 236 PKQFDVIVTDNLFGDMLSDIAAMLTGSIGMLPSASLGAPDVKTKKRKALYEPVHGSAPDI 295 Query: 1011 GNDKILQQKKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTST 1187 I ANP+A+ S AM LR+ ADRLE A+ V+ +G RT+D+ Sbjct: 296 AGKGI-----ANPIAMIASFAMCLRYSFGMVDEADRLEGAIAAVLDQG-LRTKDIFSPGM 349 Query: 1188 TQ----EVTDAVIAK 1220 T+ E+ DA+IAK Sbjct: 350 TEVGTVEMGDAIIAK 364
>Q8XXX5:LEU3_RALSO 3-isopropylmalate dehydrogenase - Ralstonia solanacearum (Pseudomonas| solanacearum) Length = 356 Score = 105 bits (262), Expect = 5e-22 Identities = 112/363 (30%), Positives = 168/363 (46%), Gaps = 36/363 (9%) Frame = +3 Query: 243 VTLIPGDGIGP-LVTGAVR------QVMEAMHAPVCFETYEVHGDMPSVPTEVIESIRRN 401 + ++PGDGIG +V AV+ + E APV YE G +P + ++ + Sbjct: 4 IAVLPGDGIGTEIVAEAVKVLKTLGETFEMETAPVGGAGYEAKGH--PLPEDTLKLAKEA 61 Query: 402 KVCLKGGLAT------PVGGGVSSLNLQLRKELDLYASLVNCFNLPGL-------PTRHE 542 L G + P L LRK L L+A+ P L P Sbjct: 62 DAILFGAVGDWKYDTLPRELRPEQAILGLRKHLQLFANFRPAICYPELAGASSMKPEIVA 121 Query: 543 NVDIAVIRENTEGEYSGLEHEV-------VPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE T Y G V G E M E RIA AF+ A Sbjct: 122 GLDILIVRELTGDIYFGQPRGVRAAPDGLFAGAREGFDTMRYSEPEIRRIAHVAFQAA-A 180 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V KAN+++ + + +V +YP ++ + + VDN MQLV P+ FDV+ Sbjct: 181 KRGKKLCSVDKANVLETFQ-FWKDIVTDVHKEYPEVELSHMYVDNAAMQLVKAPKNFDVV 239 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQG-ASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ AA + ++ ++E SA ++ I ANP Sbjct: 240 VTGNMFGDILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGI-----ANP 294 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQ----EVTDAVI 1214 +A LS+AMMLR+ L ADR+E+AVK V+A+G YRT D+ Q E+ DAV+ Sbjct: 295 LATILSAAMMLRYTLGKAEQADRIENAVKKVLAQG-YRTGDILTPGCKQVGTVEMGDAVV 353 Query: 1215 AKL 1223 A L Sbjct: 354 AAL 356
>Q5H4C7:LEU3_XANOR 3-isopropylmalate dehydrogenase - Xanthomonas oryzae pv. oryzae| Length = 357 Score = 105 bits (261), Expect = 6e-22 Identities = 111/365 (30%), Positives = 170/365 (46%), Gaps = 36/365 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFE---------TYEVHGDMPSVPTEVI 383 + + ++PGDGIGP + +V++ + + FE Y+ +G + E + Sbjct: 3 KQILILPGDGIGPEIMAEAVKVLQRIDTQHGLGFELVYDELGGAAYDKYGS--PLADETL 60 Query: 384 ESIRRNKVCLKGGLATPVGGGVS-SLN-----LQLRKELDLYASLVNCFNLPGL------ 527 E R L G + P + SL L++R +L L+A+L P L Sbjct: 61 ERARAADAVLLGAVGGPQWDTIDPSLRPERGLLKIRSQLGLFANLRPALLYPQLADASTL 120 Query: 528 -PTRHENVDIAVIRENTEGEYSGL---EHEVVPGVVESLKVMTKFCSE--RIAKYAFEYA 689 P +D+ ++RE T G Y G + G ++ + SE RIAK FE A Sbjct: 121 KPEVVAGLDLLILRELTGGIYFGQPRGNRTLDNGERQAYDTLPYSESEICRIAKAGFEMA 180 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD 869 L KK+ +V KAN++ + L+ EVA YP I + + VDN MQLV P+QFD Sbjct: 181 RLRG-KKLCSVDKANVLASSQ-LWRAVVEEVAKDYPDIALSHMYVDNAAMQLVRAPKQFD 238 Query: 870 VMVTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKA 1043 V+VT N++G+++S+ A+ + ++E SA ++ I A Sbjct: 239 VIVTDNMFGDILSDQASMLTGSIGMLPSASLDANSKGMYEPCHGSAPDIAGKGI-----A 293 Query: 1044 NPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVT----DA 1208 NP+A LS AMMLR+ AD +E AV V+ +G RT D+ TT+ T DA Sbjct: 294 NPLATILSVAMMLRYTFAQADAADAIERAVGKVLDQG-LRTADIWSEGTTKVGTVAMGDA 352 Query: 1209 VIAKL 1223 V+A L Sbjct: 353 VVAAL 357
>Q2P762:LEU3_XANOM 3-isopropylmalate dehydrogenase - Xanthomonas oryzae pv. oryzae| (strain MAFF 311018) Length = 357 Score = 105 bits (261), Expect = 6e-22 Identities = 111/365 (30%), Positives = 170/365 (46%), Gaps = 36/365 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFE---------TYEVHGDMPSVPTEVI 383 + + ++PGDGIGP + +V++ + + FE Y+ +G + E + Sbjct: 3 KQILILPGDGIGPEIMAEAVKVLQRIDTQHGLGFELVYDELGGAAYDKYGS--PLADETL 60 Query: 384 ESIRRNKVCLKGGLATPVGGGVS-SLN-----LQLRKELDLYASLVNCFNLPGL------ 527 E R L G + P + SL L++R +L L+A+L P L Sbjct: 61 ERARAADAVLLGAVGGPQWDTIDPSLRPERGLLKIRSQLGLFANLRPALLYPQLADASTL 120 Query: 528 -PTRHENVDIAVIRENTEGEYSGL---EHEVVPGVVESLKVMTKFCSE--RIAKYAFEYA 689 P +D+ ++RE T G Y G + G ++ + SE RIAK FE A Sbjct: 121 KPEVVAGLDLLILRELTGGIYFGQPRGNRTLDNGERQAYDTLPYSESEICRIAKAGFEMA 180 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD 869 L KK+ +V KAN++ + L+ EVA YP I + + VDN MQLV P+QFD Sbjct: 181 RLRG-KKLCSVDKANVLASSQ-LWRAVVEEVAKDYPDIALSHMYVDNAAMQLVRAPKQFD 238 Query: 870 VMVTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKA 1043 V+VT N++G+++S+ A+ + ++E SA ++ I A Sbjct: 239 VIVTDNMFGDILSDQASMLTGSIGMLPSASLDANSKGMYEPCHGSAPDIAGKGI-----A 293 Query: 1044 NPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVT----DA 1208 NP+A LS AMMLR+ AD +E AV V+ +G RT D+ TT+ T DA Sbjct: 294 NPLATILSVAMMLRYTFAQADAADAIERAVGKVLDQG-LRTADIWSEGTTKVGTVAMGDA 352 Query: 1209 VIAKL 1223 V+A L Sbjct: 353 VVAAL 357
>Q21XI1:LEU3_RHOFD 3-isopropylmalate dehydrogenase - Rhodoferax ferrireducens (strain| DSM 15236 / ATCC BAA-621 / T118) Length = 356 Score = 105 bits (261), Expect = 6e-22 Identities = 109/355 (30%), Positives = 166/355 (46%), Gaps = 35/355 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAPVCFET-------YEVHGDMPSVPTEVIESIRRN 401 + ++PGDGIG + +V+ A+ + ET YE G +P ++ + Sbjct: 3 IAVLPGDGIGTEIVAEAVKVLNALDLKLEMETALVGGAAYEAFGH--PLPDATLKLAKEA 60 Query: 402 KVCLKGG--------LATPVGGGVSSLNLQLRKELDLYAS---------LVNCFNLPGLP 530 L G L P+ + L L RK L L+A+ LV+ +L P Sbjct: 61 DAVLFGAVGDWKYDKLDRPLRPEQAILGL--RKNLGLFANFRPAICYEQLVDASSLK--P 116 Query: 531 TRHENVDIAVIRENTEGEYSGLEHEV-------VPGVVESLKVM--TKFCSERIAKYAFE 683 +DI +IRE T Y G PG E+ M ++ ERIA AF+ Sbjct: 117 ELIAGLDILIIRELTGDIYFGQPRGRRTATDGHFPGAEEAFDTMRYSRPEIERIAHVAFQ 176 Query: 684 YAYLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQ 863 A + K+VT+V KAN+++ + + EV +YP ++ + + VDN MQLV P++ Sbjct: 177 AARKRS-KRVTSVDKANVLETFQ-FWRDVLTEVGQQYPDVELDHMYVDNAAMQLVRAPKK 234 Query: 864 FDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGN-DKILQQKK 1040 FDV+VT NL+G+++S+ AA + QG + G+ I + Sbjct: 235 FDVVVTGNLFGDILSDEAAMLTGSIGMLPSASLNAS----SQGLYEPSHGSAPDIAGKGV 290 Query: 1041 ANPVALFLSSAMMLR-HLQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVT 1202 ANP+A LS+AMMLR L A R+E+AVK V+ +G RT D+ T TT+ T Sbjct: 291 ANPLATILSAAMMLRFSLNQEVAAQRIEAAVKDVLVQG-LRTADIFSTGTTRVST 344
>Q3A3B2:LEU3_PELCD 3-isopropylmalate dehydrogenase - Pelobacter carbinolicus (strain DSM| 2380 / Gra Bd 1) Length = 365 Score = 105 bits (261), Expect = 6e-22 Identities = 102/363 (28%), Positives = 164/363 (45%), Gaps = 36/363 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFETY-------EVHGDMPSVPTEVIESIR 395 + ++PGDGIGP + +V++A+ V FE + D ++P +E + Sbjct: 7 LAVLPGDGIGPEIMAEAMKVLDAVEQKFQVRFERQFANVGGAAIDRDGKALPDATVEICQ 66 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASLVNCFNLPGLPTRHE---- 542 + L G + P + + L LR+ L+ +L P L + Sbjct: 67 ASDAILFGSVGGPKWDTLPAEERPERGALLPLRRIFGLFCNLRPAIVFPALTSASSLKEE 126 Query: 543 ----NVDIAVIRENTEGEY----SGLEHEVVPGVVESLKVMTKFCSERIAKYAFEYAYLN 698 DI V+RE T G Y G+E E T ERI + AF+ A Sbjct: 127 VIAGGFDILVVRELTGGIYFAQPKGVEGEGGERRGFDTMAYTDAEVERITRVAFDAARKR 186 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 KK+ ++ KAN++ + L+ E V+ YP + + + VDN MQLV P+QFDV++ Sbjct: 187 G-KKLVSIDKANVLSTSV-LWREVVERVSADYPDVVLSHMYVDNAAMQLVKAPKQFDVLL 244 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQ-DHAVFE-QGASAGNVGNDKILQQKKANPV 1052 PN++G+++S+ AA + + ++E G SA ++ I ANPV Sbjct: 245 CPNMFGDILSDEAAMLTGSLGMLPSASLAEGSFGMYEPAGGSAPDIAGKNI-----ANPV 299 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGK-----YRTRDLGGTSTTQEVTDAVI 1214 A LS+AM+LR+ AD +E AV+ +A G Y+ D +T + DAV+ Sbjct: 300 AQILSAAMLLRYSCGLADAADAVEKAVENCLAAGLRTGDIYQDADGEQLVSTSAMGDAVV 359 Query: 1215 AKL 1223 A+L Sbjct: 360 AEL 362
>Q7VQJ7:LEU3_BLOFL 3-isopropylmalate dehydrogenase - Blochmannia floridanus| Length = 364 Score = 105 bits (261), Expect = 6e-22 Identities = 95/353 (26%), Positives = 163/353 (46%), Gaps = 32/353 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP----VCFETYEVHGDM-----PSVPTEVIESIR 395 + ++PGDGIGP + +++ + + Y+V G+ +P + I++ Sbjct: 8 IAILPGDGIGPEIMQQAYKILNTVKNKFKINIITTEYKVGGNALDLEGSPLPKDTIKNCE 67 Query: 396 RNKVCLKGGLATPVGGGVSSLN-------LQLRKELDLYASL------VNCFNLPGLPTR 536 ++ L G + P ++ + L LRK +L+ +L + NL L Sbjct: 68 KSNAILFGAVGGPKWNNINETSRPEFGALLTLRKHFNLFINLRPIYLPIELINLSPLKPE 127 Query: 537 --HENVDIAVIRENTEGEYSGLEHEVVPGVVES-----LKVMTKFCSERIAKYAFEYAYL 695 + +D+ IRE G Y G + + G+ + +F ERIA +AF+ A Sbjct: 128 IISQGLDMICIRELIGGIYFG-KPQGKSGIRSQEHAFDTAIYHRFEIERIAHFAFKLAQ- 185 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 RK VT++ KAN++ + L+ + EVA+ YP + + VDN MQL+ P FDV+ Sbjct: 186 KRRKHVTSIDKANVLHTSM-LWRKVVSEVASNYPNVHLQHLYVDNASMQLIRNPSAFDVI 244 Query: 876 VTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFE-QGASAGNVGNDKILQQKKANP 1049 + PNL+G+++S+ A I + ++E G SA ++ I ANP Sbjct: 245 LCPNLFGDILSDECAEINGSIGILPSASLNEHNFGLYEPAGGSAPDIAGKNI-----ANP 299 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVTD 1205 +A LS+A++ R+ L+ A +E AV + G YRT+D+ TD Sbjct: 300 IAQILSTALLFRYSLKLNHVAITIEKAVYKALTLG-YRTQDIAYNKQKSVNTD 351
>Q30WD0:LEU3_DESDG 3-isopropylmalate dehydrogenase - Desulfovibrio desulfuricans (strain| G20) Length = 358 Score = 104 bits (260), Expect = 8e-22 Identities = 109/356 (30%), Positives = 162/356 (45%), Gaps = 43/356 (12%) Frame = +3 Query: 243 VTLIPGDGIGP-----------LVTGAVRQVMEAMHAPVCFETYEVHGDMPSVPTEVIES 389 + L+ GDGIGP V G ME A + + GD +P E +E+ Sbjct: 5 ICLLAGDGIGPEIMEQGVRVLETVAGKFGHDMEFTDALIGGAAIDETGD--PLPQETVEA 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASL----------VNCFNLP 521 + + L G + P ++ L +RK L L+A+L CF P Sbjct: 63 CKAAQAVLLGAVGGPRWDNLTGAERPEAGLLGIRKALGLFANLRPAKLFPELASACFLRP 122 Query: 522 GLPTRHENVDIAVIRENTEGEYSGLE--HEVVPGVVESLKVMTKFCSE--RIAKYAFEYA 689 + +D+ V+RE T G Y G E G+ + M E RIA+ AFE A Sbjct: 123 DIVAN--GIDVMVVRELTGGIYFGTPAGEETRDGLRTAFNTMVYNEEEVRRIARVAFEAA 180 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVAT-----KYPGIQYNEIIVDNCCMQLVAK 854 + + V +V KAN++ ++ RE+ T ++P ++ + + VDN MQLV Sbjct: 181 RKRSGR-VCSVDKANVLAVS-----RLWREIVTATHADEFPDVELSHMYVDNAAMQLVRD 234 Query: 855 PEQFDVMVTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQ-DHAVFE--QGASAGNVGNDKI 1025 P QFDV+VT NL+G+++S+ A+ I +FE G++ G Sbjct: 235 PSQFDVIVTGNLFGDILSDEASVITGSIGMLPSASLGAGGPGLFEPIHGSAPDIAG---- 290 Query: 1026 LQQKKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL---GGT 1181 Q KANP+A LS+AMMLRH A+ +E AV+ V+ G YRT D+ GGT Sbjct: 291 --QNKANPLATILSTAMMLRHSFGLEKEAEAVEGAVQQVLKAG-YRTGDIMDQGGT 343
>Q8P5L1:LEU3_XANCP 3-isopropylmalate dehydrogenase - Xanthomonas campestris pv.| campestris Length = 357 Score = 104 bits (259), Expect = 1e-21 Identities = 106/363 (29%), Positives = 166/363 (45%), Gaps = 34/363 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS---------VPTEVIES 389 + + ++PGDGIGP + +V+ + V+ ++ + E +E Sbjct: 3 KQILILPGDGIGPEIMAEAVKVLTRIDTQHTLGVTLVYDELGGAAYDKYGSPLADETLER 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------P 530 R L G + P + L++R +L L+A+L P L P Sbjct: 63 ARAADAVLLGAVGGPQWDTIDPALRPERGLLKIRSQLGLFANLRPALLYPQLADASTLKP 122 Query: 531 TRHENVDIAVIRENTEGEYSGLEH---EVVPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +D+ ++RE T G Y G + G ++ + SE RIAK FE A L Sbjct: 123 EVVSGLDLLILRELTGGIYFGQPRGTRTLDNGERQAYDTLPYSESEIRRIAKAGFEMARL 182 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V KAN++ + L+ EVA YP I + + VDN MQLV P+QFDV+ Sbjct: 183 RG-KKLCSVDKANVLASSQ-LWRAVVEEVAKDYPDIALSHMYVDNAAMQLVRAPKQFDVI 240 Query: 876 VTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ A+ + ++E SA ++ I ANP Sbjct: 241 VTDNMFGDILSDQASMLTGSIGMLPSASLDANSKGMYEPCHGSAPDIAGQGI-----ANP 295 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVT----DAVI 1214 +A LS AMMLR+ + AD +E+AV V+ +G RT D+ TT+ T DAV+ Sbjct: 296 LATILSVAMMLRYTFAQAAAADAIEAAVGKVLDQG-LRTADIWSEGTTKVGTAAMGDAVV 354 Query: 1215 AKL 1223 A L Sbjct: 355 AAL 357
>Q4UYG2:LEU3_XANC8 3-isopropylmalate dehydrogenase - Xanthomonas campestris pv.| campestris (strain 8004) Length = 357 Score = 104 bits (259), Expect = 1e-21 Identities = 106/363 (29%), Positives = 166/363 (45%), Gaps = 34/363 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAPVCFETYEVHGDMPS---------VPTEVIES 389 + + ++PGDGIGP + +V+ + V+ ++ + E +E Sbjct: 3 KQILILPGDGIGPEIMAEAVKVLTRIDTQHTLGVTLVYDELGGAAYDKYGSPLADETLER 62 Query: 390 IRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL-------P 530 R L G + P + L++R +L L+A+L P L P Sbjct: 63 ARAADAVLLGAVGGPQWDTIDPALRPERGLLKIRSQLGLFANLRPALLYPQLADASTLKP 122 Query: 531 TRHENVDIAVIRENTEGEYSGLEH---EVVPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +D+ ++RE T G Y G + G ++ + SE RIAK FE A L Sbjct: 123 EVVSGLDLLILRELTGGIYFGQPRGTRTLDNGERQAYDTLPYSESEIRRIAKAGFEMARL 182 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V KAN++ + L+ EVA YP I + + VDN MQLV P+QFDV+ Sbjct: 183 RG-KKLCSVDKANVLASSQ-LWRAVVEEVAKDYPDIALSHMYVDNAAMQLVRAPKQFDVI 240 Query: 876 VTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ A+ + ++E SA ++ I ANP Sbjct: 241 VTDNMFGDILSDQASMLTGSIGMLPSASLDANSKGMYEPCHGSAPDIAGQGI-----ANP 295 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVT----DAVI 1214 +A LS AMMLR+ + AD +E+AV V+ +G RT D+ TT+ T DAV+ Sbjct: 296 LATILSVAMMLRYTFAQAAAADAIEAAVGKVLDQG-LRTADIWSEGTTKVGTAAMGDAVV 354 Query: 1215 AKL 1223 A L Sbjct: 355 AAL 357
>Q67JY2:LEU3_SYMTH 3-isopropylmalate dehydrogenase - Symbiobacterium thermophilum| Length = 368 Score = 103 bits (258), Expect = 1e-21 Identities = 106/351 (30%), Positives = 155/351 (44%), Gaps = 41/351 (11%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAMHAP----VCFETYEVHGDMPSV-----PTEVIESIR 395 + +PGDGIGP VT V++A A + F Y V G P E ++ Sbjct: 8 IACLPGDGIGPEVTRGAVTVLQAAAAAYGFRLEFSEYLVGGAAYDAVGTPFPDETRDACD 67 Query: 396 RNKVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGL----PTRHE- 542 R L G + P G+ + L +RK DLYA+L P L P ++E Sbjct: 68 RADAILFGAVGGPRYEGLPWDLRPEAGLLAIRKRYDLYANLRPILLYPPLKDASPLKNEI 127 Query: 543 ---NVDIAVIRENTEGEYSGLEH--EVVPGVVE---SLKVMTKFCSERIAKYAFEYAYLN 698 VD ++RE G Y G E +P + +V T RIA+ FE A Sbjct: 128 IGGGVDFIIVRELVGGIYFGEPRGIETLPDGTRRGVNTEVYTDAEIARIARMGFEIAR-G 186 Query: 699 NRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVMV 878 R+++T+V K N+M+ A L+ EVA ++P ++ ++ DN MQ++ +P FDVM+ Sbjct: 187 RRRRLTSVDKGNVME-AGKLWRTVVDEVAREFPDVEVEHLLADNAAMQILRRPGDFDVML 245 Query: 879 TPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDK------------ 1022 NL+G+ +S+ AA + GA+ G K Sbjct: 246 ASNLFGDFLSDEAAMLTGSIGLLPSA---------SLGAARNRFGLPKGFYEPIHGSAPD 296 Query: 1023 ILQQKKANPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL 1172 I Q +ANP+A L AM+LRH L A +E AV V+ EG RT D+ Sbjct: 297 IAGQDRANPLAAILCGAMLLRHSLGREDAARAVEQAVAAVLEEG-LRTADI 346
>Q393X4:LEU3_BURS3 3-isopropylmalate dehydrogenase - Burkholderia sp. (strain 383)| (Burkholderia cepacia (strain ATCC 17760 / NCIB 9086 / R18194)) Length = 355 Score = 103 bits (258), Expect = 1e-21 Identities = 107/363 (29%), Positives = 168/363 (46%), Gaps = 36/363 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-------HAPVCFETYEVHGDMPSVPTEVIESIRRN 401 + ++PGDGIGP + +V+ A+ APV YE G +P ++ + Sbjct: 3 IAVLPGDGIGPEIVNEAVKVLNALDEKFELEQAPVGGAGYEASGH--PLPDATLKLAKEA 60 Query: 402 KVCLKGGLATPVGGGVS------SLNLQLRKELDLYASLVNCFNLPGL-------PTRHE 542 L G + + L LRK L+L+A+ P L P Sbjct: 61 DAILFGAVGDWKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASPLKPELVA 120 Query: 543 NVDIAVIRENTEGEYSGLEHEV-------VPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE Y G V G E M E RIA AF+ A Sbjct: 121 GLDILIVRELNGDIYFGQPRGVRTAPDGLFAGEREGFDTMRYSEPEVRRIAHVAFQAAR- 179 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V KAN+++ + + + +V+ +Y ++ + + VDN MQL P+QFDV+ Sbjct: 180 KRAKKLLSVDKANVLETSQ-FWRDIMIDVSKEYADVELSHMYVDNAAMQLAKAPKQFDVI 238 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQG-ASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ A+ + +++ ++E SA ++ I ANP Sbjct: 239 VTGNMFGDILSDEASMLTGSIGMLPSASLDKNNKGLYEPSHGSAPDIAGKGI-----ANP 293 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL---GGTST-TQEVTDAVI 1214 +A LS+AMMLR+ L ADR+E AVK V+ +G YRT D+ GG T + DAV+ Sbjct: 294 LATILSAAMMLRYSLNRAEQADRIERAVKTVLEQG-YRTGDIATPGGQQVGTTAMGDAVV 352 Query: 1215 AKL 1223 A L Sbjct: 353 AAL 355
>Q3SNU3:LEU3_NITWN 3-isopropylmalate dehydrogenase - Nitrobacter winogradskyi (strain| Nb-255 / ATCC 25391) Length = 370 Score = 103 bits (257), Expect = 2e-21 Identities = 109/363 (30%), Positives = 169/363 (46%), Gaps = 37/363 (10%) Frame = +3 Query: 249 LIPGDGIGPLVTGAVRQVMEAMHAP--VCFETYE-------VHGDMPSVPTEVIESIRRN 401 L+PGDGIGP V V++++ + A FET E D S+ + Sbjct: 8 LLPGDGIGPEVMAEVKRLVGWLDAQGIAKFETEEGLVGGASYDADKVSITDATMAKALAA 67 Query: 402 KVCLKGGLATPVGGGV------SSLNLQLRKELDLYASLVNCFNLPGL-------PTRHE 542 L G + P V + L+LRK+L LYA+L P L P E Sbjct: 68 DAVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLALYANLRPAICYPALAESSSLKPEVVE 127 Query: 543 NVDIAVIRENTEGEYSGLEHEVVPGVVESLK------VMTKFCSERIAKYAFEYAYLNNR 704 +DI ++RE T G Y G E + V + K V + ERIA+ AF+ A R Sbjct: 128 GLDIMIVRELTGGVYFG-EPKTVTDLGNGQKRAVDTQVYDTYEIERIARVAFDLAR-KRR 185 Query: 705 KKVTAVHKANIMKLADGLFLESCREVATK-YPGIQYNEIIVDNCCMQLVAKPEQFDVMVT 881 K+T++ K N+MK L+ E +V + Y + + D+ MQLV P+QFDV+VT Sbjct: 186 NKLTSMEKRNVMKTGV-LWHEVVTQVHQREYKDVALQHQLADSGGMQLVRWPKQFDVIVT 244 Query: 882 PNLYGNLVSNVAAGIAXXXXXXXXXXXXQDHAVFEQGASAGNVGNDK---ILQQKKANPV 1052 NL+G+++S++AA + E+ + + I Q ANP+ Sbjct: 245 DNLFGDMLSDIAAMLTGSLGMLPSASLGDTDPKTEKRRALYEPVHGSAPDIAGQGLANPI 304 Query: 1053 ALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDL---GGT-STTQEVTDAVIA 1217 A+ S M LR+ AD+L++A+ V+A+G RT DL G T +T ++ +A++ Sbjct: 305 AMLASFGMALRYSFDRGDLADKLDAAIAAVLAKG-LRTADLKSEGATVVSTSQMGEAIVK 363 Query: 1218 KLD 1226 +L+ Sbjct: 364 ELE 366
>Q2T7H6:LEU3_BURTA 3-isopropylmalate dehydrogenase - Burkholderia thailandensis (strain| E264 / ATCC 700388 / DSM 13276 / CIP 106301) Length = 355 Score = 103 bits (257), Expect = 2e-21 Identities = 105/363 (28%), Positives = 166/363 (45%), Gaps = 36/363 (9%) Frame = +3 Query: 243 VTLIPGDGIGPLVTGAVRQVMEAM-------HAPVCFETYEVHGDMPSVPTEVIESIRRN 401 + ++PGDGIGP + +V+ A+ HAPV YE G +P + + Sbjct: 3 IAVLPGDGIGPEIVNEAVKVLNALDEKFELEHAPVGGAGYEASGH--PLPDATLALAKEA 60 Query: 402 KVCLKGGLATPVGGGVS------SLNLQLRKELDLYASLVNCFNLPGL-------PTRHE 542 L G + + L LRK L+L+A+ P L P Sbjct: 61 DAILFGAVGDWKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASPLKPELVA 120 Query: 543 NVDIAVIRENTEGEYSGLEHEV-------VPGVVESLKVMTKFCSE--RIAKYAFEYAYL 695 +DI ++RE Y G V G E M E RIA AF+ A Sbjct: 121 GLDILIVRELNGDIYFGQPRGVRAAPDGPFAGEREGFDTMRYSEPEVRRIAHVAFQAAQ- 179 Query: 696 NNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFDVM 875 KK+ +V K+N+++ + + + +V+ +Y ++ + + VDN MQL P+QFDV+ Sbjct: 180 KRAKKLLSVDKSNVLETSQ-FWRDVMIDVSKEYADVELSHMYVDNAAMQLAKAPKQFDVI 238 Query: 876 VTPNLYGNLVSNVAAGIAXXXXXXXXXXXXQDH-AVFEQG-ASAGNVGNDKILQQKKANP 1049 VT N++G+++S+ A+ + +++ ++E SA ++ I ANP Sbjct: 239 VTGNMFGDILSDEASMLTGSIGMLPSASLDKNNKGLYEPSHGSAPDIAGKGI-----ANP 293 Query: 1050 VALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVT----DAVI 1214 +A LS+AM+LR+ L ADR+E AVK V+ +G YRT D+ Q T DAV+ Sbjct: 294 LATILSAAMLLRYSLNRAEQADRIERAVKTVLEQG-YRTGDIATPGCRQVGTAAMGDAVV 352 Query: 1215 AKL 1223 A L Sbjct: 353 AAL 355
>Q8PH05:LEU3_XANAC 3-isopropylmalate dehydrogenase - Xanthomonas axonopodis pv. citri| Length = 357 Score = 103 bits (256), Expect = 2e-21 Identities = 108/365 (29%), Positives = 170/365 (46%), Gaps = 36/365 (9%) Frame = +3 Query: 237 RTVTLIPGDGIGPLVTGAVRQVMEAMHAP--VCFE---------TYEVHGDMPSVPTEVI 383 + + ++PGDGIGP + +V++ + A + F+ Y+ +G + E + Sbjct: 3 KQILILPGDGIGPEIMAEAVKVLKRIDAQHGLGFQLVYDELGGTAYDKYGS--PLADETL 60 Query: 384 ESIRRNKVCLKGGLATPVGGGVSSLN------LQLRKELDLYASLVNCFNLPGL------ 527 E R L G + P + L++R +L L+A+L P L Sbjct: 61 ERARGADAVLLGAVGGPQWDTIDPALRPERGLLKIRSQLGLFANLRPALLYPQLADASTL 120 Query: 528 -PTRHENVDIAVIRENTEGEYSGL---EHEVVPGVVESLKVMTKFCSE--RIAKYAFEYA 689 P +D+ ++RE T G Y G + G ++ + SE RIAK F+ A Sbjct: 121 KPEVVAGLDLLILRELTGGIYFGQPRGNRTLDNGERQAYDTLPYSESEIRRIAKAGFDMA 180 Query: 690 YLNNRKKVTAVHKANIMKLADGLFLESCREVATKYPGIQYNEIIVDNCCMQLVAKPEQFD 869 L KK+ +V KAN++ + L+ EVA YP I + + VDN MQLV P+QFD Sbjct: 181 RLRG-KKLCSVDKANVLASSQ-LWRAVVEEVAKDYPDIALSHMYVDNAAMQLVRAPKQFD 238 Query: 870 VMVTPNLYGNLVSNVAAGI-AXXXXXXXXXXXXQDHAVFEQ-GASAGNVGNDKILQQKKA 1043 V+VT N++G+++S+ A+ + ++E SA ++ I A Sbjct: 239 VIVTDNMFGDILSDQASMLTGSIGMLPSASLDANSKGMYEPCHGSAPDIAGKGI-----A 293 Query: 1044 NPVALFLSSAMMLRH-LQFPSFADRLESAVKGVIAEGKYRTRDLGGTSTTQEVT----DA 1208 NP+A LS AMMLR+ + AD +E AV V+ +G RT D+ TT+ T DA Sbjct: 294 NPLATILSVAMMLRYTFARATAADAIEHAVGKVLDQG-LRTADIWSEGTTKVGTVAMGDA 352 Query: 1209 VIAKL 1223 V+A L Sbjct: 353 VVAAL 357 Database: uniprot_sprot.fasta.out Posted date: Jul 19, 2007 5:58 PM Number of letters in database: 100,686,439 Number of sequences in database: 274,295 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 274295 Number of Hits to DB: 220,046,168 Number of extensions: 4616568 Number of successful extensions: 15095 Number of sequences better than 10.0: 352 Number of HSP's gapped: 14209 Number of HSP's successfully gapped: 361 Length of query: 494 Length of database: 100,686,439 Length adjustment: 117 Effective length of query: 377 Effective length of database: 68,593,924 Effective search space: 25859909348 Effective search space used: 25859909348 Neighboring words threshold: 12 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
