Clone Name	FLbaf96p06
Clone Library Name	barley_pub

---

No.	Definition	Score (bits)	E Value
1	Q94AH6:CUL1_ARATH Cullin-1 - Arabidopsis thaliana (Mouse-ear cress)	910	0.0
2	Q13619:CUL4A_HUMAN Cullin-4A - Homo sapiens (Human)	284	e-111
3	Q13620:CUL4B_HUMAN Cullin-4B - Homo sapiens (Human)	281	e-109
4	Q3TCH7:CUL4A_MOUSE Cullin-4A - Mus musculus (Mouse)	281	e-109
5	Q13618:CUL3_HUMAN Cullin-3 - Homo sapiens (Human)	278	e-103
6	Q9JLV5:CUL3_MOUSE Cullin-3 - Mus musculus (Mouse)	277	e-103
7	Q17391:CUL3_CAEEL Cullin-3 - Caenorhabditis elegans	240	3e-84
8	Q5RCF3:CUL2_PONPY Cullin-2 - Pongo pygmaeus (Orangutan)	214	9e-79
9	Q13617:CUL2_HUMAN Cullin-2 - Homo sapiens (Human)	214	9e-79
10	Q17389:CUL1_CAEEL Cullin-1 - Caenorhabditis elegans	233	1e-77
11	Q9D4H8:CUL2_MOUSE Cullin-2 - Mus musculus (Mouse)	209	4e-77
12	O13790:CUL1_SCHPO Cullin-1 - Schizosaccharomyces pombe (Fission ...	213	7e-75
13	Q5R4G6:CUL1_PONPY Cullin-1 - Pongo pygmaeus (Orangutan)	280	2e-74
14	Q9WTX6:CUL1_MOUSE Cullin-1 - Mus musculus (Mouse)	280	2e-74
15	Q13616:CUL1_HUMAN Cullin-1 - Homo sapiens (Human)	280	2e-74
16	Q21346:CUL6_CAEEL Cullin-6 - Caenorhabditis elegans	192	9e-67
17	Q17390:CUL2_CAEEL Cullin-2 - Caenorhabditis elegans	183	1e-65
18	Q24311:CUL1_DROME Cullin homolog 1 - Drosophila melanogaster (Fr...	248	1e-64
19	Q17392:CUL4_CAEEL Cullin-4 - Caenorhabditis elegans	147	2e-57
20	Q09760:CUL3_SCHPO Cullin-3 - Schizosaccharomyces pombe (Fission ...	197	2e-49
21	Q9D5V5:CUL5_MOUSE Cullin-5 - Mus musculus (Mouse)	171	2e-41
22	Q9JJ31:CUL5_RAT Cullin-5 - Rattus norvegicus (Rat)	170	3e-41
23	Q12018:CDC53_YEAST Cell division control protein 53 - Saccharomy...	169	6e-41
24	Q29425:CUL5_RABIT Cullin-5 - Oryctolagus cuniculus (Rabbit)	168	1e-40
25	Q93034:CUL5_HUMAN Cullin-5 - Homo sapiens (Human)	168	1e-40
26	Q5RB36:CUL5_PONPY Cullin-5 - Pongo pygmaeus (Orangutan)	168	1e-40
27	Q23639:CUL5_CAEEL Cullin-5 - Caenorhabditis elegans	147	2e-34
28	O14122:CUL4_SCHPO Cullin-4 - Schizosaccharomyces pombe (Fission ...	147	2e-34
29	P53202:CUL3_YEAST Cullin-3 - Saccharomyces cerevisiae (Baker's y...	87	8e-32
30	Q8BZQ7:ANC2_MOUSE Anaphase-promoting complex subunit 2 - Mus mus...	50	7e-05
31	Q9UJX6:ANC2_HUMAN Anaphase-promoting complex subunit 2 - Homo sa...	49	9e-05
32	P34514:ANC2_CAEEL Anaphase-promoting complex subunit 2 - Caenorh...	42	0.014
33	Q874R3:APC2_SCHPO Anaphase-promoting complex subunit 2 - Schizos...	39	0.16
34	Q68WR2:SYW_RICTY Tryptophanyl-tRNA synthetase - Rickettsia typhi	36	1.0
35	Q9GL21:UACA_CANFA Uveal autoantigen with coiled-coil domains and...	35	1.7
36	Q3TES0:IQEC3_MOUSE IQ motif and Sec7 domain-containing protein 3...	35	2.2
37	Q9HIH6:Y1363_THEAC Putative HTH-type transcriptional regulatory ...	34	2.9
38	P62134:RAD50_METMP DNA double-strand break repair rad50 ATPase -...	34	2.9
39	P31630:VGNM_CPSMV Genome polyprotein M - Cowpea severe mosaic vi...	34	3.8
40	P12270:TPR_HUMAN Nucleoprotein TPR - Homo sapiens (Human)	34	3.8
41	Q53EZ4:CEP55_HUMAN Centrosomal protein of 55 kDa - Homo sapiens ...	34	3.8
42	Q9BZF9:UACA_HUMAN Uveal autoantigen with coiled-coil domains and...	33	5.0
43	Q99N96:RM01_MOUSE 39S ribosomal protein L1, mitochondrial precur...	33	5.0
44	P50491:AMA1_PLAFH Apical membrane antigen 1 precursor - Plasmodi...	33	5.0
45	P50492:AMA1_PLAF8 Apical membrane antigen 1 precursor - Plasmodi...	33	5.0
46	Q76M68:IQEC3_RAT IQ motif and Sec7 domain-containing protein 3 -...	33	6.5
47	Q9X1B6:SYA_THEMA Alanyl-tRNA synthetase - Thermotoga maritima	33	6.6
48	P47849:RF1_COXBU Peptide chain release factor 1 - Coxiella burnetii	33	6.6
49	Q8CGB3:UACA_MOUSE Uveal autoantigen with coiled-coil domains and...	33	8.6
50	Q13439:GOGA4_HUMAN Golgin subfamily A member 4 - Homo sapiens (H...	33	8.6

---

>Q94AH6:CUL1_ARATH Cullin-1 - Arabidopsis thaliana (Mouse-ear cress)|
          Length = 738
 Score =  910 bits (2352), Expect(2) = 0.0
 Identities = 438/548 (79%), Positives = 495/548 (90%)
 Frame = +1

Query: 187  ERKTVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQ 366
            ERKT+DLE+GW +MQ GITKLK ILEG  EP F SE YMMLYTTIYNMCTQKPPHDYSQQ
Sbjct: 2    ERKTIDLEQGWDYMQTGITKLKRILEGLNEPAFDSEQYMMLYTTIYNMCTQKPPHDYSQQ 61

Query: 367  LYDKYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFIS 546
            LYDKYRE+FEEYI+S VLP+LREKHDEFMLREL KRWSNHKVMVRWLSRFF+YLDRYFI+
Sbjct: 62   LYDKYREAFEEYINSTVLPALREKHDEFMLRELFKRWSNHKVMVRWLSRFFYYLDRYFIA 121

Query: 547  RRSLPALREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQIDRALLKNVLDIFVEIG 726
            RRSLP L EVGL+CFRDLVY E+  KVK AVI+L+D+EREGEQIDRALLKNVLDI+VEIG
Sbjct: 122  RRSLPPLNEVGLTCFRDLVYNELHSKVKQAVIALVDKEREGEQIDRALLKNVLDIYVEIG 181

Query: 727  LGSMECYENDFEDFLLKDTADYYSIKAQTWIVEDSCPDYMLKAEECLKREKERVAHYLHS 906
            +G ME YE DFE F+L+DT+ YYS KA +WI EDSCPDYMLK+EECLK+E+ERVAHYLHS
Sbjct: 182  MGQMERYEEDFESFMLQDTSSYYSRKASSWIQEDSCPDYMLKSEECLKKERERVAHYLHS 241

Query: 907  SSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFSRITRGLEPVS 1086
            SSEPKL+EKVQHELL  +ASQLLEKEHSGC ALLRDDKV+DLSRMYRL+ +I RGLEPV+
Sbjct: 242  SSEPKLVEKVQHELLVVFASQLLEKEHSGCRALLRDDKVDDLSRMYRLYHKILRGLEPVA 301

Query: 1087 QIFKQHVTNEGTALVKQAEDAASNKKPEKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQ 1266
             IFKQHVT EG ALV+QAED A+N   +  +   +QEQV +RK+IELHDKY+ YVT+CFQ
Sbjct: 302  NIFKQHVTAEGNALVQQAEDTATN---QVANTASVQEQVLIRKVIELHDKYMVYVTECFQ 358

Query: 1267 GHTLFHKALKEAFEVFCNKGVSGSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVR 1446
             HTLFHKALKEAFE+FCNK V+GSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVV+
Sbjct: 359  NHTLFHKALKEAFEIFCNKTVAGSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVK 418

Query: 1447 LLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDL 1626
            LLAYISDKDLFAEFYRKKLARRLLFD+SAND+HERSILTKLKQQCGGQFTSKMEGMVTDL
Sbjct: 419  LLAYISDKDLFAEFYRKKLARRLLFDRSANDDHERSILTKLKQQCGGQFTSKMEGMVTDL 478

Query: 1627 TVARDHQTKFEEFISTHPELNPGIDLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFKEF 1806
            T+AR++Q  FE+++ ++P  NPGIDL VTVLTTGFWP+YKSFDINLP+EM++CVEVFK F
Sbjct: 479  TLARENQNSFEDYLGSNPAANPGIDLTVTVLTTGFWPSYKSFDINLPSEMIKCVEVFKGF 538

Query: 1807 YQTRTKQK 1830
            Y+T+TK +
Sbjct: 539  YETKTKHR 546



 Score =  293 bits (750), Expect(2) = 0.0
 Identities = 145/193 (75%), Positives = 162/193 (83%)
 Frame = +2

Query: 1826 KKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEIVTQLNLSDDDV 2005
            +KLTWIYSLG CHI  KF+ K IELIV+TYQAA+LLLFN  DKLSY+EI+ QLNLS +D+
Sbjct: 546  RKLTWIYSLGTCHINGKFDQKAIELIVSTYQAAVLLLFNTTDKLSYTEILAQLNLSHEDL 605

Query: 2006 VRLLHSLSCAKYKILTKEPSNRSISPNDVFEFNSKFTDKMRRIKIPLPPXXXXXXXXXXX 2185
            VRLLHSLSCAKYKIL KEP+ +++S ND FEFNSKFTD+MRRIKIPLPP           
Sbjct: 606  VRLLHSLSCAKYKILLKEPNTKTVSQNDAFEFNSKFTDRMRRIKIPLPPVDERKKVVEDV 665

Query: 2186 XXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPDFKAIKKRIEDLITRDYLE 2365
               RRYAIDA+IVRIMKSRKVLGHQ LV ECVEQL RMFKPD KAIKKR+EDLITRDYLE
Sbjct: 666  DKDRRYAIDAAIVRIMKSRKVLGHQQLVSECVEQLSRMFKPDIKAIKKRMEDLITRDYLE 725

Query: 2366 RDKENPNVYRYLA 2404
            RDKENPN++RYLA
Sbjct: 726  RDKENPNMFRYLA 738

---

>Q13619:CUL4A_HUMAN Cullin-4A - Homo sapiens (Human)|
          Length = 759

 Score =  284 bits (727), Expect(2) = e-111
 Identities = 167/505 (33%), Positives = 290/505 (57%), Gaps = 4/505 (0%)
 Frame = +1

Query: 307  LYTTIYNMCTQKPPHDYSQQLYDKYRESFEEYISSMVLPSLREKHDEFM-LRELVKRWSN 483
            LY  + N+C+    H  S  LY + R++ E+++ + +LP   +  D  + L+++   W +
Sbjct: 86   LYQAVENLCS----HKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQD 141

Query: 484  HKVMVRWLSRFFHYLDR-YFISRRSLPALREVGLSCFRDLVYQE--IKGKVKSAVISLID 654
            H   +  +   F +LDR Y +   +LP++ ++GL  FR  +  +  ++ K    ++ LI+
Sbjct: 142  HCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIE 201

Query: 655  QEREGEQIDRALLKNVLDIFVEIGLGSMECYENDFEDFLLKDTADYYSIKAQTWIVEDSC 834
            +ER GE +DR+LL+++L +     L  ++ Y++ FE   L++T   Y+ + Q  + E   
Sbjct: 202  RERSGEAVDRSLLRSLLGM-----LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREV 256

Query: 835  PDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRD 1014
            P+Y+    + L+ E +RV  YL  S++  L+  V+ +LL ++ + +L+K   G   LL +
Sbjct: 257  PEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQK---GLDHLLDE 313

Query: 1015 DKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKKPEKKDIVGLQ 1194
            ++V DL++MY+LFSR+  G + + Q + +++   GTA+V           PEK       
Sbjct: 314  NRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVIN---------PEK------- 357

Query: 1195 EQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKGVSGSSSAELLATFCDN 1374
            ++  V+ +++  DK    +  CFQ +  F   +KE+FE F NK    +  AEL+A   D+
Sbjct: 358  DKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK--RPNKPAELIAKHVDS 415

Query: 1375 ILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERS 1554
             L+ G  E  +DE +E TL+K++ L  +I  KD+F  FY+K LA+RLL  KSA+ + E+S
Sbjct: 416  KLRAGNKEA-TDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKS 474

Query: 1555 ILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNPGIDLAVTVLTTGFW 1734
            +L+KLK +CG  FTSK+EGM  D+ +++D    F++ +    +  P IDL V +LT G+W
Sbjct: 475  MLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP-IDLTVNILTMGYW 533

Query: 1735 PTYKSFDINLPAEMVRCVEVFKEFY 1809
            PTY   +++L  EM++  EVFK FY
Sbjct: 534  PTYTPMEVHLTPEMIKLQEVFKAFY 558



 Score =  140 bits (352), Expect(2) = e-111
 Identities = 82/208 (39%), Positives = 111/208 (53%), Gaps = 4/208 (1%)
 Frame = +2

Query: 1793 FSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEI 1972
            F   ++ +   +KL W  +LG   + A+F+    E  V+ +Q  +LL+FN  D  S+ EI
Sbjct: 554  FKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEI 613

Query: 1973 VTQLNLSDDDVVRLLHSLSCAKYKILTKEPSNRSISPNDVFEFNSKFTDKMRRIKI---- 2140
                 + D ++ R L SL+C K ++L K P  + +   D F FN +F  K+ RIKI    
Sbjct: 614  KMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQ 673

Query: 2141 PLPPXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPDFKA 2320
                              R+Y IDA+IVRIMK RK LGH  LV E   QL    KP    
Sbjct: 674  MKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPG--D 731

Query: 2321 IKKRIEDLITRDYLERDKENPNVYRYLA 2404
            +KKRIE LI RDY+ERDK+NPN Y Y+A
Sbjct: 732  LKKRIESLIDRDYMERDKDNPNQYHYVA 759

---

>Q13620:CUL4B_HUMAN Cullin-4B - Homo sapiens (Human)|
          Length = 895

 Score =  281 bits (719), Expect(2) = e-109
 Identities = 167/538 (31%), Positives = 310/538 (57%), Gaps = 4/538 (0%)
 Frame = +1

Query: 208  EEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQLYDKYRE 387
            +E W  +++ +  ++N    K    ++ E+   LY  + N+C+ K     S  LY + R+
Sbjct: 196  DETWQKLKEAVEAIQNSTSIK----YNLEE---LYQAVENLCSYK----ISANLYKQLRQ 244

Query: 388  SFEEYISSMVLPSLREKHDEFM-LRELVKRWSNHKVMVRWLSRFFHYLDRYFISRRS-LP 561
              E++I + +     +  D  + L+++ + W NH   +  +   F +LDR ++ + S LP
Sbjct: 245  ICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLP 304

Query: 562  ALREVGLSCFRDLVY--QEIKGKVKSAVISLIDQEREGEQIDRALLKNVLDIFVEIGLGS 735
            ++ ++GL  FR  +   Q+++ K    ++ LI++ER GE IDR+LL+++L +     L  
Sbjct: 305  SIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSM-----LSD 359

Query: 736  MECYENDFEDFLLKDTADYYSIKAQTWIVEDSCPDYMLKAEECLKREKERVAHYLHSSSE 915
            ++ Y++ FE   L++T   Y+ + Q  + E   P+Y+    + L+ E +R+  YL  +++
Sbjct: 360  LQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQ 419

Query: 916  PKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFSRITRGLEPVSQIF 1095
              L+  V+ +LL ++ + +L+K   G + LL +++++DLS +Y+LFSR+  G++ + Q +
Sbjct: 420  KSLIATVEKQLLGEHLTAILQK---GLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQW 476

Query: 1096 KQHVTNEGTALVKQAEDAASNKKPEKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHT 1275
             +++   G+ +V           PEK       ++  V+++++  DK    +  CF  + 
Sbjct: 477  IEYIKAFGSTIVIN---------PEK-------DKTMVQELLDFKDKVDHIIDICFLKNE 520

Query: 1276 LFHKALKEAFEVFCNKGVSGSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLA 1455
             F  A+KEAFE F NK    +  AEL+A + D+ L+ G  E  +DE +E  L+K++ +  
Sbjct: 521  KFINAMKEAFETFINK--RPNKPAELIAKYVDSKLRAGNKEA-TDEELEKMLDKIMIIFR 577

Query: 1456 YISDKDLFAEFYRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVA 1635
            +I  KD+F  FY+K LA+RLL  KSA+ + E+S+L+KLK +CG  FTSK+EGM  D+ ++
Sbjct: 578  FIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELS 637

Query: 1636 RDHQTKFEEFISTHPELNPGIDLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFKEFY 1809
            +D   +F++++  +  +   I+L V +LT G+WPTY   +++LP EMV+  E+FK FY
Sbjct: 638  KDIMIQFKQYMQ-NQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFY 694



 Score =  139 bits (349), Expect(2) = e-109
 Identities = 83/208 (39%), Positives = 110/208 (52%), Gaps = 4/208 (1%)
 Frame = +2

Query: 1793 FSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEI 1972
            F   ++ +   +KL W  +LG C + A+F+    EL V+ +Q  +LL+FN  ++ S  EI
Sbjct: 690  FKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEI 749

Query: 1973 VTQLNLSDDDVVRLLHSLSCAKYKILTKEPSNRSISPNDVFEFNSKFTDKMRRIKI---- 2140
                 + D ++ R L SL+C K ++L K P  + I   D F  N  F  K+ RIKI    
Sbjct: 750  KQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQ 809

Query: 2141 PLPPXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPDFKA 2320
                              R+Y IDA+IVRIMK RK L H  LV E   QL    KP    
Sbjct: 810  MKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKP--AD 867

Query: 2321 IKKRIEDLITRDYLERDKENPNVYRYLA 2404
            +KKRIE LI RDY+ERDKENPN Y Y+A
Sbjct: 868  LKKRIESLIDRDYMERDKENPNQYNYIA 895

---

>Q3TCH7:CUL4A_MOUSE Cullin-4A - Mus musculus (Mouse)|
          Length = 759

 Score =  281 bits (718), Expect(2) = e-109
 Identities = 168/505 (33%), Positives = 287/505 (56%), Gaps = 4/505 (0%)
 Frame = +1

Query: 307  LYTTIYNMCTQKPPHDYSQQLYDKYRESFEEYISSMVLPSLREKHDEFM-LRELVKRWSN 483
            LY  + N+C+    H  S  LY + R+  E+++ + +LP   +  D  + L+++   W +
Sbjct: 86   LYQAVENLCS----HKVSPTLYKQLRQVCEDHVQAQILPFREDSLDSVLFLKKINTCWQD 141

Query: 484  HKVMVRWLSRFFHYLDRYFISRRS-LPALREVGLSCFRDLVYQE--IKGKVKSAVISLID 654
            H   +  +   F +LDR ++ + S LP++ ++GL  FR+ +  +  ++ K    ++ LI 
Sbjct: 142  HCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRNHIISDRMVQSKTIDGILLLIG 201

Query: 655  QEREGEQIDRALLKNVLDIFVEIGLGSMECYENDFEDFLLKDTADYYSIKAQTWIVEDSC 834
            +ER GE +DR+LL+++L +     L  ++ Y++ FE   L++T   Y+ + Q  + +   
Sbjct: 202  RERSGEAVDRSLLRSLLSM-----LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQDREV 256

Query: 835  PDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRD 1014
            P+Y+    + L+ E +RV  YL  S++  L+  V+ +LL ++ + +L+K   G   LL +
Sbjct: 257  PEYLNHVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLGEHLTAILQK---GLEHLLDE 313

Query: 1015 DKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKKPEKKDIVGLQ 1194
            ++V DL++MY+LFSR+  G   + Q + +++   GT +V           PEK       
Sbjct: 314  NRVPDLTQMYQLFSRVKGGQHALLQHWSEYIKTFGTTIVIN---------PEK------- 357

Query: 1195 EQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKGVSGSSSAELLATFCDN 1374
            ++  V+ +++  DK    V  CFQ +  F   +KE+FE F NK    +  AEL+A   D+
Sbjct: 358  DKDMVQDLLDFKDKVDHVVEVCFQRNERFINLMKESFETFINK--RPNKPAELIAKHVDS 415

Query: 1375 ILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERS 1554
             L+ G  E  +DE +E  L+K++ L  +I  KD+F  FY+K LA+RLL  KSA+ + E+S
Sbjct: 416  KLRAGNKEA-TDEELERILDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKS 474

Query: 1555 ILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNPGIDLAVTVLTTGFW 1734
            +L+KLK +CG  FTSK+EGM  D+ +++D    F++ +       P IDL V +LT G+W
Sbjct: 475  MLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSAPGP-IDLTVNILTMGYW 533

Query: 1735 PTYKSFDINLPAEMVRCVEVFKEFY 1809
            PTY   +++LP EMVR  EVFK FY
Sbjct: 534  PTYTPMEVHLPPEMVRLQEVFKTFY 558



 Score =  137 bits (344), Expect(2) = e-109
 Identities = 81/208 (38%), Positives = 110/208 (52%), Gaps = 4/208 (1%)
 Frame = +2

Query: 1793 FSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEI 1972
            F   ++ +   +KL W  +LG   + A F+    E  V+ +Q  +LL+FN  D  S+ EI
Sbjct: 554  FKTFYLGKHSGRKLQWQTTLGHAVLKADFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEI 613

Query: 1973 VTQLNLSDDDVVRLLHSLSCAKYKILTKEPSNRSISPNDVFEFNSKFTDKMRRIKI---- 2140
                 + D ++ R L SL+C K ++L K P  + +   D F FN+ F  K+ RIKI    
Sbjct: 614  KMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNADFKHKLFRIKINQIQ 673

Query: 2141 PLPPXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPDFKA 2320
                              R+Y IDA+IVRIMK RK LGH  LV E   QL    KP    
Sbjct: 674  MKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPG--D 731

Query: 2321 IKKRIEDLITRDYLERDKENPNVYRYLA 2404
            +KKRIE LI RDY+ERDK++PN Y Y+A
Sbjct: 732  LKKRIESLIDRDYMERDKDSPNQYHYVA 759

---

>Q13618:CUL3_HUMAN Cullin-3 - Homo sapiens (Human)|
          Length = 768

 Score =  278 bits (711), Expect(2) = e-103
 Identities = 156/524 (29%), Positives = 286/524 (54%), Gaps = 3/524 (0%)
 Frame = +1

Query: 247  LKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQLYDKYRESFEEYISSMVLPS 426
            LKN ++       S   +  LY   Y M      H + ++LY   RE   E++ + V   
Sbjct: 37   LKNAIQEIQRKNNSGLSFEELYRNAYTMVL----HKHGEKLYTGLREVVTEHLINKVRED 92

Query: 427  LREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRRSLPALREVGLSCFRDLV- 603
            +    +   L+ L + W++H+  +  +     Y+DR ++ + ++  +  +GL  FRD V 
Sbjct: 93   VLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVV 152

Query: 604  -YQEIKGKVKSAVISLIDQEREGEQIDRALLKNVLDIFVEIGLGSMECYENDFEDFLLKD 780
             Y  I+  ++  ++ +I +ER+GE +DR  ++N   + + +GL     YE DFE   L+ 
Sbjct: 153  RYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEM 212

Query: 781  TADYYSIKAQTWIVEDSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQY 960
            +A+++ +++Q ++ E+S   Y+ K E  +  E ERV H L  S+E  +++ V+ EL++++
Sbjct: 213  SAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKH 272

Query: 961  ASQLLEKEHSGCHALLRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQA 1140
               ++E E+SG   +L++ K EDL  MY+LFSR+  GL+ + +    ++  +G ALV + 
Sbjct: 273  MKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEE 332

Query: 1141 EDAASNKKPEKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCN 1320
             +             G     +++ +++L  ++  ++ + F    LF + +   FE F N
Sbjct: 333  GE-------------GKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLN 379

Query: 1321 KGVSGSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKK 1500
                 S S E L+ F D+ LKK G + L+++ +E  L+K + L  ++ +KD+F  +Y++ 
Sbjct: 380  ---LNSRSPEYLSLFIDDKLKK-GVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQH 435

Query: 1501 LARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHP 1680
            LARRLL +KS +D+ E+++++KLK +CG QFTSK+EGM  D++++     +F + +    
Sbjct: 436  LARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATG 495

Query: 1681 ELNPGIDLAVTVLTTGFWPTYKSF-DINLPAEMVRCVEVFKEFY 1809
                G+DL V VLTTG+WPT  +    N+P       E+F+ FY
Sbjct: 496  VSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFY 539



 Score =  121 bits (303), Expect(2) = e-103
 Identities = 73/193 (37%), Positives = 106/193 (54%), Gaps = 8/193 (4%)
 Frame = +2

Query: 1850 LGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEIVTQLNLSDDDVVRLLHSLS 2029
            +G   +T     K I L V+T+Q  +L+LFN  +K ++ EI  + ++ + ++VR L SL+
Sbjct: 577  VGGAQVTGSNTRKHI-LQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLA 635

Query: 2030 CAK--YKILTKEPSNRSISPNDVFEFNSKFTDKMRRIKIPL------PPXXXXXXXXXXX 2185
            C K   ++LTKEP ++ I    +F  N +FT K+ R+KI                     
Sbjct: 636  CGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKV 695

Query: 2186 XXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPDFKAIKKRIEDLITRDYLE 2365
               R++ I+A+IVRIMKSRK + H  LV E  +QL   F P    IKKRIE LI R+YL 
Sbjct: 696  DDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLA 755

Query: 2366 RDKENPNVYRYLA 2404
            R  E+  VY Y+A
Sbjct: 756  RTPEDRKVYTYVA 768

---

>Q9JLV5:CUL3_MOUSE Cullin-3 - Mus musculus (Mouse)|
          Length = 768

 Score =  277 bits (709), Expect(2) = e-103
 Identities = 156/524 (29%), Positives = 287/524 (54%), Gaps = 3/524 (0%)
 Frame = +1

Query: 247  LKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQLYDKYRESFEEYISSMVLPS 426
            LKN ++       S   +  LY   Y M      H + ++LY   RE   E++ + V   
Sbjct: 37   LKNAIQEIQRKNNSGLSFEELYRNAYTMVL----HKHGEKLYTGLREVVTEHLINKVRED 92

Query: 427  LREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRRSLPALREVGLSCFRDLV- 603
            +    +   L+ L + W++H+  +  +     Y+DR ++ + ++  +  +GL  FRD V 
Sbjct: 93   VLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVV 152

Query: 604  -YQEIKGKVKSAVISLIDQEREGEQIDRALLKNVLDIFVEIGLGSMECYENDFEDFLLKD 780
             Y  I+  ++  ++ +I +ER+GE +DR  ++N   + + +GL     YE DFE   L+ 
Sbjct: 153  RYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEM 212

Query: 781  TADYYSIKAQTWIVEDSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQY 960
            +A+++ +++Q ++ E+S   Y+ K E  +  E ERV H L  S+E  +++ V+ EL++++
Sbjct: 213  SAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKH 272

Query: 961  ASQLLEKEHSGCHALLRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQA 1140
               ++E E+SG   +L++ K EDL+ MY+LFSR+  GL+ + +    ++  +G ALV + 
Sbjct: 273  MKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSCYLREQGKALVSEE 332

Query: 1141 EDAASNKKPEKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCN 1320
             +             G     +++ +++L  ++  ++ + F    LF + +   FE F N
Sbjct: 333  GE-------------GKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLN 379

Query: 1321 KGVSGSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKK 1500
                 S S E L+ F D+ LKK G + L+++ +E  L+K + L  ++ +KD+F  +Y++ 
Sbjct: 380  ---LNSRSPEYLSLFIDDKLKK-GVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQH 435

Query: 1501 LARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHP 1680
            LARRLL +KS +D+ E+++++KLK +CG QFTSK+EGM  D++++     +F + +    
Sbjct: 436  LARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATG 495

Query: 1681 ELNPGIDLAVTVLTTGFWPTYKSF-DINLPAEMVRCVEVFKEFY 1809
                G+DL V VLTTG+WPT  +    N+P       E+F+ FY
Sbjct: 496  VSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFY 539



 Score =  121 bits (304), Expect(2) = e-103
 Identities = 73/193 (37%), Positives = 106/193 (54%), Gaps = 8/193 (4%)
 Frame = +2

Query: 1850 LGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEIVTQLNLSDDDVVRLLHSLS 2029
            +G   +T     K I L V+T+Q  +L+LFN  +K ++ EI  + ++ + ++VR L SL+
Sbjct: 577  VGGAQVTGSNTRKHI-LQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLA 635

Query: 2030 CAK--YKILTKEPSNRSISPNDVFEFNSKFTDKMRRIKIPL------PPXXXXXXXXXXX 2185
            C K   ++LTKEP ++ I    +F  N +FT K+ R+KI                     
Sbjct: 636  CGKPTQRVLTKEPKSKEIESGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKV 695

Query: 2186 XXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPDFKAIKKRIEDLITRDYLE 2365
               R++ I+A+IVRIMKSRK + H  LV E  +QL   F P    IKKRIE LI R+YL 
Sbjct: 696  DDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLA 755

Query: 2366 RDKENPNVYRYLA 2404
            R  E+  VY Y+A
Sbjct: 756  RTPEDRKVYTYVA 768

---

>Q17391:CUL3_CAEEL Cullin-3 - Caenorhabditis elegans|
          Length = 777

 Score =  240 bits (612), Expect(2) = 3e-84
 Identities = 150/551 (27%), Positives = 287/551 (52%), Gaps = 14/551 (2%)
 Frame = +1

Query: 247  LKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQLYDKYRESFEEYISSMVLPS 426
            LK  ++       S   +  LY   Y M      H + ++LY+  ++  +++++S+ +  
Sbjct: 34   LKRAIQEIQRKNNSGLSFEELYRNAYTMVL----HKHGERLYNGLKDVIQDHMASVRIRI 89

Query: 427  LREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRRS--LPALREVGLSCFRDL 600
            +   +    L  + + W++H V +  +     Y+DR ++++ +  LP    +GL  +R  
Sbjct: 90   IESMNSGSFLETVAESWADHTVAMVMIRDILMYMDRIYVAQNNHVLPVYN-LGLDAYRTE 148

Query: 601  VYQE--IKGKVKSAVISLIDQEREGEQIDRALLKNVLDIFVEIGLGSMECYENDFEDFLL 774
            + ++  I  +++ A++ LI  +R+  QI+   +KN  D+ + +G+ S   YE++FE  LL
Sbjct: 149  ILRQNGIGDRIRDALLELIKLDRKSNQINWHGIKNACDMLISLGIDSRTVYEDEFERPLL 208

Query: 775  KDTADYYSIKAQTWIV--EDSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHEL 948
            K+T+DYY    + W+    D+C  Y+ + E  +  E  R + YL   +E K+L+ +   +
Sbjct: 209  KETSDYYRDVCKNWLSGDNDAC-FYLAQVEIAMHDEASRASRYLDKMTEAKILQVMDDVM 267

Query: 949  LTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFSRITR-------GLEPVSQIFKQHV 1107
            + ++   ++  ++ G   +L   K+EDL+R++R+F RI         GL+ + +   +++
Sbjct: 268  VAEHIQTIVYMQNGGVKFMLEHKKIEDLTRIFRIFKRIGDSVTVPGGGLKALLKAVSEYL 327

Query: 1108 TNEGTALVKQAEDAASNKKPEKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHK 1287
               G+ +VK  ED   N               FV ++++L D + + +T  F     F  
Sbjct: 328  NETGSNIVKN-EDLLKNPVN------------FVNELLQLKDYFSSLLTTAFADDRDFKN 374

Query: 1288 ALKEAFEVFCNKGVSGSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISD 1467
              +  FE F N   S   S E +A + D++L+ G  + +SD  +++ L+ V+ L  Y+ +
Sbjct: 375  RFQHDFETFLN---SNRQSPEFVALYMDDMLRSG-LKCVSDAEMDNKLDNVMILFRYLQE 430

Query: 1468 KDLFAEFYRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQ 1647
            KD+F +++++ LA+RLL DKS +D+ E+++L KLK +CG QFT K+E M  D  +     
Sbjct: 431  KDVFEKYFKQYLAKRLLLDKSCSDDVEKALLAKLKTECGCQFTQKLENMFRDKELWLTLA 490

Query: 1648 TKFEEFISTHPELNPGIDLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFKEFY-QTRTK 1824
            T F ++    P     ID+++ VLT G WPT +   + LP E+    E+F ++Y +  T 
Sbjct: 491  TSFRDWREAQP-TKMSIDISLRVLTAGVWPTVQCNPVVLPQELSVAYEMFTQYYTEKHTG 549

Query: 1825 QKTYMDIFLGN 1857
            +K  ++  LGN
Sbjct: 550  RKLTINTLLGN 560



 Score = 95.5 bits (236), Expect(2) = 3e-84
 Identities = 58/177 (32%), Positives = 92/177 (51%), Gaps = 8/177 (4%)
 Frame = +2

Query: 1898 LIVTTYQAALLLLFNGADKLSYSEIVTQLNLSDDDVVRLLHSLSCAKYK---ILTKEPSN 2068
            L V T+Q  +LL FN  +++S  +++ +L + + ++ R L SL+  K     ++ K    
Sbjct: 601  LQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGK 660

Query: 2069 RSISPNDVFEFNSKFTDKMRRIKIPL-----PPXXXXXXXXXXXXXXRRYAIDASIVRIM 2233
             +I  +D F  N  F  K+ R+K+ +                     R+  ++A+IVRIM
Sbjct: 661  DAIDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIM 720

Query: 2234 KSRKVLGHQTLVMECVEQLGRMFKPDFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
            K+RK L H  LV E  +QL   F P    IK+RIE LI R+YL RD+ +   Y+Y+A
Sbjct: 721  KARKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777

---

>Q5RCF3:CUL2_PONPY Cullin-2 - Pongo pygmaeus (Orangutan)|
          Length = 745

 Score =  214 bits (545), Expect(2) = 9e-79
 Identities = 150/566 (26%), Positives = 268/566 (47%), Gaps = 27/566 (4%)
 Frame = +1

Query: 193  KTVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQLY 372
            + VD +E W    K +T +K ++  +   + +  D    ++ IY +C   P     ++LY
Sbjct: 6    RVVDFDETW---NKLLTTIKAVVMLEYVERATWNDR---FSDIYALCVAYP-EPLGERLY 58

Query: 373  DKYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRR 552
             + +   E ++  +    L  +    ++    + W  +     ++   + YL+  FI + 
Sbjct: 59   TETKIFLENHVRHLHKRVLESEEQVLVMYH--RYWEEYSKGADYMDCLYRYLNTQFIKKN 116

Query: 553  SLPA------------------LREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQI 678
             L                    + E+ L  +R L+ + ++  +   ++  I  +R GE  
Sbjct: 117  KLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDP 176

Query: 679  DRALLKNVLDIFVEIGLGS----MECYENDFEDFLLKDTADYYSIKAQTWIVEDSCPDYM 846
            ++ ++  V++ FV +        ++ Y+  FE   L +T +YY  +A   + E +C  YM
Sbjct: 177  NQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYM 236

Query: 847  LKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVE 1026
             K    LK E+ R   YLH SS  K++ + Q  ++  +   L    H+ CH ++R +K  
Sbjct: 237  EKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFL----HAECHNIIRQEKKN 292

Query: 1027 DLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKKPEKKDIVGLQEQVF 1206
            D++ MY L   ++ GL  + Q  + H+ +EG         A SN   E          +F
Sbjct: 293  DMANMYVLLRAVSTGLPHMIQELQNHIHDEGLR-------ATSNLTQEN------MPTLF 339

Query: 1207 VRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCN--KGVSGSSSAELLATFCDNIL 1380
            V  ++E+H K+V  +     G   F  AL +A     N  +  S   + ELLA +CDN+L
Sbjct: 340  VESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLL 399

Query: 1381 KKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSIL 1560
            KK  ++ +++  +ED L   + +  YI DKD+F +FY + LA+RL+   S + + E +++
Sbjct: 400  KKS-AKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMI 458

Query: 1561 TKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPE-LNPGIDLAVTVLTTGFWP 1737
             KLKQ CG +FTSK+  M TD++V+ D   KF  FI      ++ GI   + VL  G WP
Sbjct: 459  NKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWP 518

Query: 1738 TYK--SFDINLPAEMVRCVEVFKEFY 1809
              +  S    +P E+ + V++F+ FY
Sbjct: 519  LTQAPSSTFAIPQELEKSVQMFELFY 544



 Score =  102 bits (255), Expect(2) = 9e-79
 Identities = 63/205 (30%), Positives = 98/205 (47%), Gaps = 5/205 (2%)
 Frame = +2

Query: 1805 FIKQELS-KKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEIVTQ 1981
            F  Q  S +KLTW++ L    +   +  K    +VTTYQ A+LL FN ++ +SY E+   
Sbjct: 543  FYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDS 602

Query: 1982 LNLSDDDVVRLLHSLSCAKYKILTKEPSNRSISPNDVFEFNSKFTDKMRRIKIPLP---- 2149
              +++ ++ + + SL     K++  +     I     F  N  F+ K  + KI       
Sbjct: 603  TQMNEKELTKTIKSL--LDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD 660

Query: 2150 PXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPDFKAIKK 2329
                           R+  + A+IVRIMK+RKVL H  L+ E + Q    F P    IKK
Sbjct: 661  TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK 720

Query: 2330 RIEDLITRDYLERDKENPNVYRYLA 2404
             IE LI + Y+ER + + + Y Y+A
Sbjct: 721  CIEVLIDKQYIERSQASADEYSYVA 745

---

>Q13617:CUL2_HUMAN Cullin-2 - Homo sapiens (Human)|
          Length = 745

 Score =  214 bits (545), Expect(2) = 9e-79
 Identities = 150/566 (26%), Positives = 268/566 (47%), Gaps = 27/566 (4%)
 Frame = +1

Query: 193  KTVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQLY 372
            + VD +E W    K +T +K ++  +   + +  D    ++ IY +C   P     ++LY
Sbjct: 6    RVVDFDETW---NKLLTTIKAVVMLEYVERATWNDR---FSDIYALCVAYP-EPLGERLY 58

Query: 373  DKYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRR 552
             + +   E ++  +    L  +    ++    + W  +     ++   + YL+  FI + 
Sbjct: 59   TETKIFLENHVRHLHKRVLESEEQVLVMYH--RYWEEYSKGADYMDCLYRYLNTQFIKKN 116

Query: 553  SLPA------------------LREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQI 678
             L                    + E+ L  +R L+ + ++  +   ++  I  +R GE  
Sbjct: 117  KLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDP 176

Query: 679  DRALLKNVLDIFVEIGLGS----MECYENDFEDFLLKDTADYYSIKAQTWIVEDSCPDYM 846
            ++ ++  V++ FV +        ++ Y+  FE   L +T +YY  +A   + E +C  YM
Sbjct: 177  NQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYM 236

Query: 847  LKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVE 1026
             K    LK E+ R   YLH SS  K++ + Q  ++  +   L    H+ CH ++R +K  
Sbjct: 237  EKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFL----HAECHNIIRQEKKN 292

Query: 1027 DLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKKPEKKDIVGLQEQVF 1206
            D++ MY L   ++ GL  + Q  + H+ +EG         A SN   E          +F
Sbjct: 293  DMANMYVLLRAVSTGLPHMIQELQNHIHDEGLR-------ATSNLTQEN------MPTLF 339

Query: 1207 VRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCN--KGVSGSSSAELLATFCDNIL 1380
            V  ++E+H K+V  +     G   F  AL +A     N  +  S   + ELLA +CDN+L
Sbjct: 340  VESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLL 399

Query: 1381 KKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSIL 1560
            KK  ++ +++  +ED L   + +  YI DKD+F +FY + LA+RL+   S + + E +++
Sbjct: 400  KKS-AKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMI 458

Query: 1561 TKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPE-LNPGIDLAVTVLTTGFWP 1737
             KLKQ CG +FTSK+  M TD++V+ D   KF  FI      ++ GI   + VL  G WP
Sbjct: 459  NKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWP 518

Query: 1738 TYK--SFDINLPAEMVRCVEVFKEFY 1809
              +  S    +P E+ + V++F+ FY
Sbjct: 519  LTQAPSSTFAIPQELEKSVQMFELFY 544



 Score =  102 bits (255), Expect(2) = 9e-79
 Identities = 63/205 (30%), Positives = 98/205 (47%), Gaps = 5/205 (2%)
 Frame = +2

Query: 1805 FIKQELS-KKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEIVTQ 1981
            F  Q  S +KLTW++ L    +   +  K    +VTTYQ A+LL FN ++ +SY E+   
Sbjct: 543  FYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDS 602

Query: 1982 LNLSDDDVVRLLHSLSCAKYKILTKEPSNRSISPNDVFEFNSKFTDKMRRIKIPLP---- 2149
              +++ ++ + + SL     K++  +     I     F  N  F+ K  + KI       
Sbjct: 603  TQMNEKELTKTIKSL--LDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD 660

Query: 2150 PXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPDFKAIKK 2329
                           R+  + A+IVRIMK+RKVL H  L+ E + Q    F P    IKK
Sbjct: 661  TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK 720

Query: 2330 RIEDLITRDYLERDKENPNVYRYLA 2404
             IE LI + Y+ER + + + Y Y+A
Sbjct: 721  CIEVLIDKQYIERSQASADEYSYVA 745

---

>Q17389:CUL1_CAEEL Cullin-1 - Caenorhabditis elegans|
          Length = 780

 Score =  233 bits (594), Expect(2) = 1e-77
 Identities = 172/604 (28%), Positives = 298/604 (49%), Gaps = 56/604 (9%)
 Frame = +1

Query: 175  MTTHE--RKTVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPP 348
            MT  E  R T D E  W  +Q G+               + +DYM LYT++Y+ CT    
Sbjct: 1    MTNSEPRRMTCDSEVVWKKLQDGLDVAYR------RENMAPKDYMTLYTSVYDYCTSITL 54

Query: 349  HDYSQQLYDKYRES-------------------FEEYISSMVLPSLREKHDEFMLRELVK 471
                +   D   ES                    EEY+ + V+ ++ EK  E    +L+K
Sbjct: 55   STSRRDGEDGRAESSTPARTAGADFVGHEMYQRVEEYVKAYVI-AVCEKGAELSGEDLLK 113

Query: 472  ----RWSNHKVMVRWLSRFFHYLDRYFISRR------SLPALREVGLSCFRDLVYQEIKG 621
                 W N ++  + +   F YL+R++I R       ++  +  + L  ++  ++ ++K 
Sbjct: 114  YYTTEWENFRISSKVMDGIFAYLNRHWIRRELDEGHENIYMVYTLALVVWKRNLFNDLKD 173

Query: 622  KVKSAVISLIDQEREGEQIDRALLKNVLDIFVEIGLGSMEC-------------YENDFE 762
            KV  A++ LI  ER G  I+   +  V++  VE+G+   E              Y+  FE
Sbjct: 174  KVIDAMLELIRSERTGSMINSRYISGVVECLVELGVDDSETDAKKDAETKKLAVYKEFFE 233

Query: 763  DFLLKDTADYYSIKAQTWIVED-SCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQ 939
               L+ T  +Y+ +A  ++    +  DYM+K E  L +E +R   YL+SS++  L    +
Sbjct: 234  VKFLEATRGFYTQEAANFLSNGGNVTDYMIKVETRLNQEDDRCQLYLNSSTKTPLATCCE 293

Query: 940  HELLTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEG 1119
              L++     L  + H G   LL D + +DLSRM++L  R+  GL+ + +  + H+  EG
Sbjct: 294  SVLISNQLDFL--QRHFG--GLLVDKRDDDLSRMFKLCDRVPNGLDELRKSLENHIAKEG 349

Query: 1120 -TALVKQAEDAASNKKPEKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALK 1296
              AL + A +AA++ K            ++V+ ++E+H++Y + V   F+    F ++L 
Sbjct: 350  HQALERVAMEAATDAK------------LYVKTLLEVHERYQSLVNRSFKNEPGFMQSLD 397

Query: 1297 EAFEVFCNKGVSG---------SSSAELLATFCDNILKKGGSEKLSDEA-IEDTLEKVVR 1446
            +A   F N              + SAELLA +CD +L+K  S K+ DEA +E+   K++ 
Sbjct: 398  KAATSFINNNAVTKRAPPQAQLTKSAELLARYCDQLLRK--SSKMPDEAELEELQTKIMV 455

Query: 1447 LLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDL 1626
            +  YI DKD+F++FY K  ++RL+ + SA+DE E + +TKLK  CG ++T+++  MV D 
Sbjct: 456  VFKYIDDKDVFSKFYTKMFSKRLISELSASDEAEANFITKLKSMCGYEYTARLSKMVNDT 515

Query: 1627 TVARDHQTKFEEFISTHPELNPGIDLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFKEF 1806
             V++D    F+E           ++  V VL++G WPT+ +  I LP ++ + +E+F +F
Sbjct: 516  QVSKDLTADFKE-KKADMLGQKSVEFNVLVLSSGSWPTFPTTPITLPQQLSKTIEIFGQF 574

Query: 1807 YQTR 1818
            Y  +
Sbjct: 575  YNEK 578



 Score = 80.1 bits (196), Expect(2) = 1e-77
 Identities = 60/211 (28%), Positives = 94/211 (44%), Gaps = 7/211 (3%)
 Frame = +2

Query: 1793 FSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEI 1972
            F + + ++   ++LTW+YS     IT+    K      TT Q   +LLFN  D  +  +I
Sbjct: 571  FGQFYNEKFNGRRLTWVYSQSRGEITSTAFPKKYVFTATTAQMCTMLLFNEQDSYTVEQI 630

Query: 1973 VTQLNLSDDD----VVRLLHSLSCAKYKILTKE---PSNRSISPNDVFEFNSKFTDKMRR 2131
                 + +      V  L+ +L       L KE   P   ++S N  +  N K    + +
Sbjct: 631  AAATKMDEKSAPAIVGSLIKNLVLKADTELQKEDEVPMTATVSLNKAY-MNKKVRVDLSK 689

Query: 2132 IKIPLPPXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPD 2311
              +                  R+  I A IVRIMK+RK + HQ L+ E + QL   FKP 
Sbjct: 690  FTMKQDAVRDTENVQKNVEEDRKSVISACIVRIMKTRKRVQHQQLMTEVITQLSGRFKPK 749

Query: 2312 FKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
             + IK+ I  LI ++Y+ R +   ++Y YLA
Sbjct: 750  VEMIKRCIGSLIEKEYMLRTEGQKDLYEYLA 780

---

>Q9D4H8:CUL2_MOUSE Cullin-2 - Mus musculus (Mouse)|
          Length = 745

 Score =  209 bits (531), Expect(2) = 4e-77
 Identities = 146/566 (25%), Positives = 269/566 (47%), Gaps = 27/566 (4%)
 Frame = +1

Query: 193  KTVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQLY 372
            + VD +E W    K +T +K ++  +   + +  D    ++ IY +C   P     ++LY
Sbjct: 6    RVVDFDETW---NKLLTTIKAVVMLEYVERATWNDR---FSDIYALCVAYP-EPLGERLY 58

Query: 373  DKYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRR 552
             + +   E ++  +    L  +    ++    + W  +     ++   + YL+  +I + 
Sbjct: 59   AETKIFLESHVRHLYKRVLESEEQVLVMYH--RYWEEYSKGADYMDCLYRYLNTQYIKKN 116

Query: 553  SLPA------------------LREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQI 678
             L                    + E+ L  +R L+ + ++  +   ++  I  +R GE  
Sbjct: 117  KLTEADIQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQNILIRMLLREIKNDRGGEDP 176

Query: 679  DRALLKNVLDIFVEIGLGS----MECYENDFEDFLLKDTADYYSIKAQTWIVEDSCPDYM 846
            ++ ++  V++ FV +        ++ Y+  F    L +T +YY  +A   + E +C  YM
Sbjct: 177  NQKVIHGVINSFVHVEQYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYM 236

Query: 847  LKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVE 1026
             K    LK E+ R   YLH SS  K++ + Q  ++  +   L    HS CH++++ ++  
Sbjct: 237  EKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFL----HSECHSIIQQERKN 292

Query: 1027 DLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKKPEKKDIVGLQEQVF 1206
            D++ MY L   ++ GL  + +  ++H+ +EG         A SN   E          +F
Sbjct: 293  DMANMYVLLRAVSSGLPHMIEELQKHIHDEGLR-------ATSNLTQEH------MPTLF 339

Query: 1207 VRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCN--KGVSGSSSAELLATFCDNIL 1380
            V  ++E+H K+V  +     G   F  AL +A     N  +  S   + ELLA +CDN+L
Sbjct: 340  VESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLL 399

Query: 1381 KKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSIL 1560
            KK  ++ +++  +ED L   + +  YI DKD+F +FY + LA+RL+   S + + E +++
Sbjct: 400  KKS-AKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMI 458

Query: 1561 TKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPE-LNPGIDLAVTVLTTGFWP 1737
             KLKQ CG +FTSK+  M TD++V+ D   KF  FI      ++ GI   + VL  G WP
Sbjct: 459  NKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQDTVIDLGISFQIYVLQAGAWP 518

Query: 1738 TYK--SFDINLPAEMVRCVEVFKEFY 1809
              +  S    +P E+ + V++F+ FY
Sbjct: 519  LTQAPSSTFAIPQELEKSVQMFELFY 544



 Score =  102 bits (255), Expect(2) = 4e-77
 Identities = 63/205 (30%), Positives = 98/205 (47%), Gaps = 5/205 (2%)
 Frame = +2

Query: 1805 FIKQELS-KKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEIVTQ 1981
            F  Q  S +KLTW++ L    +   +  K    +VTTYQ A+LL FN ++ +SY E+   
Sbjct: 543  FYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDS 602

Query: 1982 LNLSDDDVVRLLHSLSCAKYKILTKEPSNRSISPNDVFEFNSKFTDKMRRIKIPLP---- 2149
              +++ ++ + + SL     K++  +     I     F  N  F+ K  + KI       
Sbjct: 603  TQMNEKELTKTIKSL--LDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKD 660

Query: 2150 PXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPDFKAIKK 2329
                           R+  + A+IVRIMK+RKVL H  L+ E + Q    F P    IKK
Sbjct: 661  TPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK 720

Query: 2330 RIEDLITRDYLERDKENPNVYRYLA 2404
             IE LI + Y+ER + + + Y Y+A
Sbjct: 721  CIEVLIDKQYIERSQASADEYSYVA 745

---

>O13790:CUL1_SCHPO Cullin-1 - Schizosaccharomyces pombe (Fission yeast)|
          Length = 767

 Score =  213 bits (542), Expect(2) = 7e-75
 Identities = 152/571 (26%), Positives = 272/571 (47%), Gaps = 31/571 (5%)
 Frame = +1

Query: 190  RKTVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQ---------- 339
            +K   L   W F++ G++++   L+       +   YM LYT I+N C            
Sbjct: 15   KKYDSLNGTWDFLKTGVSQIFERLD----EGMTITKYMELYTAIHNYCADASKTITVDNF 70

Query: 340  --KPPHDYSQQLYDKYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLSR 513
              +  +   + LY+      EEY++ +    + + + E  L    K W+      R+++ 
Sbjct: 71   NDQTANVLGEALYNNLVLYLEEYLARLRKECISQTNHEEQLAAYAKYWTRFTTSARFINH 130

Query: 514  FFHYLDRYFISRRS------LPALREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQ 675
             F YL+RY++  ++      +  +  + L  +   V+  I+  +   ++ +  ++R  E 
Sbjct: 131  LFGYLNRYWVKLKNRFTETLVYDIYTLCLVSWHHHVFSHIRDSLLQNLLYMFTKKRLYEP 190

Query: 676  IDRALLKNVLDIFVEIGLG-------SMECYENDFEDFLLKDTADYYSIKAQTWIVEDSC 834
             D   ++  +D    +          ++  Y+  FE   +++T ++Y+ ++  ++   S 
Sbjct: 191  TDMKYVEVCVDSITSLSFDKTDMTKPNLSSYKTFFETNFIENTKNFYAKESSEYLASHSI 250

Query: 835  PDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRD 1014
             DY+ KAE  L  E+E V  YLH S+   LLE  +  L+ Q+   L    H+    +L  
Sbjct: 251  TDYLKKAEIRLAEEEELVRLYLHESTLKPLLEATEDVLIAQHEEVL----HNDFARMLDQ 306

Query: 1015 DKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKKPEKKDIVGLQ 1194
            +  ED+ RMYRL SR   GL+P+ Q F++ V   G A V +         P+      + 
Sbjct: 307  NCSEDIIRMYRLMSRTPNGLQPLRQTFEEFVKRSGFAAVAKIV-------PQVGGEADVD 359

Query: 1195 EQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKGV----SGSSSAELLAT 1362
             + ++  ++  +      V   F G T F K+L  AF    N+ V    S S S ELLA 
Sbjct: 360  PKEYMEMLLSTYKASKELVNTAFHGDTDFTKSLDTAFRELVNRNVVCQRSSSRSPELLAK 419

Query: 1363 FCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDE 1542
            + D+IL+K       D+ +ED L  ++ +  Y+ DKD+F  FY K LA+RL+   S + +
Sbjct: 420  YADSILRKSNKNVDIDD-VEDCLSSIIIIFRYVEDKDVFQNFYTKLLAKRLVNGTSNSQD 478

Query: 1543 HERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNPG-IDLAVTVL 1719
             E S+L+KLK+ CG ++TSK++ M  D++++++    F +     P+   G ID +  VL
Sbjct: 479  AESSMLSKLKEVCGFEYTSKLQRMFQDISLSQEITEAFWQL----PQSRAGNIDFSALVL 534

Query: 1720 TTGFWP-TYKSFDINLPAEMVRCVEVFKEFY 1809
             T FWP +  + + +LP E+V   E F+ +Y
Sbjct: 535  GTSFWPLSPNNVNFHLPEELVPLYEGFQNYY 565



 Score = 90.9 bits (224), Expect(2) = 7e-75
 Identities = 59/196 (30%), Positives = 97/196 (49%), Gaps = 7/196 (3%)
 Frame = +2

Query: 1826 KKLTWIYSLGICHITAKFEAKT---IELIVTTYQAALLLLFNGADKLSYSEIVTQLNLSD 1996
            +KL+W++ L    I A+   +T       V+TYQ  +LLL+N  D  +Y E+     LS 
Sbjct: 572  RKLSWLFHLSKGEIKARINPQTNVTYVFQVSTYQMGVLLLYNHRDSYTYEELAKITGLST 631

Query: 1997 DDVVRLLHSLSCAKYKILTKEPSNRSISPNDVFEFNSKFTDKMRRIKIPLP----PXXXX 2164
            D +  +L+     K K+L    +++   PN  ++ N  F  K  R+++ LP         
Sbjct: 632  DFLTGILNIF--LKAKVLLLGDNDKLGDPNSTYKINENFRMKKIRVQLNLPIRSEQKQES 689

Query: 2165 XXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPDFKAIKKRIEDL 2344
                      R+  + ++IVRIMK+R+ L H  LV E ++Q+   F P    IK+ I+ L
Sbjct: 690  LETHKTIEEDRKLLLQSAIVRIMKARRTLKHVVLVKETIDQIKSRFTPKVSDIKQCIDML 749

Query: 2345 ITRDYLERDKENPNVY 2392
            I ++YLER   +  +Y
Sbjct: 750  IEKEYLERQGRDEYIY 765

---

>Q5R4G6:CUL1_PONPY Cullin-1 - Pongo pygmaeus (Orangutan)|
          Length = 776

 Score =  280 bits (717), Expect = 2e-74
 Identities = 181/590 (30%), Positives = 312/590 (52%), Gaps = 45/590 (7%)
 Frame = +1

Query: 184  HERKTVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQK------- 342
            H  K + L++ W  ++ GI ++            +   YM LYT +YN CT         
Sbjct: 10   HGLKQIGLDQIWDDLRAGIQQVYT------RQSMAKSRYMELYTHVYNYCTSVHQSNQAR 63

Query: 343  ----PPHDYSQ------------QLYDKYRESFEEYISSMVLPSLREKHDEFMLRELVKR 474
                PP    +            +LY + +E  + Y++++ L    +  DE +L+   ++
Sbjct: 64   GAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNL-LKDGEDLMDESVLKFYTQQ 122

Query: 475  WSNHKVMVRWLSRFFHYLDRYFI------SRRSLPALREVGLSCFRDLVYQEIKGKVKSA 636
            W +++   + L+    YL+R+++       R+ +  +  + L  +RD +++ +  +V +A
Sbjct: 123  WEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNA 182

Query: 637  VISLIDQEREGEQIDRALLKNVLDIFVEIGLG---------SMECYENDFEDFLLKDTAD 789
            V+ LI++ER GE I+  L+  V+  +VE+GL          ++  Y+  FE   L DT  
Sbjct: 183  VLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTER 242

Query: 790  YYSIKAQTWIVEDSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQ 969
            +Y+ ++  ++ ++   +YM KAE  L  E+ RV  YLH S++ +L  K +  L+ ++   
Sbjct: 243  FYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKH--- 299

Query: 970  LLEKEHSGCHALLRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDA 1149
             LE  H+    LL  DK EDL RMY L SRI  GL  + ++ + H+ N+G A +++  +A
Sbjct: 300  -LEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEA 358

Query: 1150 ASNKKPEKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKGV 1329
            A N             +++V+ ++++H KY A V   F     F  AL +A   F N   
Sbjct: 359  ALN-----------DPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNA 407

Query: 1330 ------SGSSSAELLATFCDNILKKGGSEKLSDEA-IEDTLEKVVRLLAYISDKDLFAEF 1488
                  S S S ELLA +CD++LKK  S K  +EA +EDTL +V+ +  YI DKD+F +F
Sbjct: 408  VTKMAQSSSKSPELLARYCDSLLKK--SSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKF 465

Query: 1489 YRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFI 1668
            Y K LA+RL+   SA+D+ E S+++KLKQ CG ++TSK++ M  D+ V++D   +F++ +
Sbjct: 466  YAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHL 525

Query: 1669 STHPELNPGIDLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFKEFYQTR 1818
            +    L+  +D ++ VL++G WP  +S    LP+E+ R  + F  FY +R
Sbjct: 526  TNSEPLD--LDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASR 573



 Score = 95.5 bits (236), Expect = 1e-18
 Identities = 64/212 (30%), Positives = 100/212 (47%), Gaps = 7/212 (3%)
 Frame = +2

Query: 1790 RFSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSE 1969
            RF+  +  +   +KLTW+Y L    +          L  +T+Q A+LL +N  D  +  +
Sbjct: 565  RFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQ 624

Query: 1970 IVTQLNLSDDDVVRLLHSLSCAKYKILTKEPSNRS---ISPNDVFEFNSKFTDKMRRIKI 2140
            +     +  D + ++L  L  +K  +L  E +N     + P+ + +    + +K  R+ I
Sbjct: 625  LTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNI 684

Query: 2141 PLP----PXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKP 2308
             +P                   R+  I A+IVRIMK RKVL HQ L+ E + QL   FKP
Sbjct: 685  NVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKP 744

Query: 2309 DFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
                IKK I+ LI ++YLER     + Y YLA
Sbjct: 745  RVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776

---

>Q9WTX6:CUL1_MOUSE Cullin-1 - Mus musculus (Mouse)|
          Length = 776

 Score =  280 bits (717), Expect = 2e-74
 Identities = 181/590 (30%), Positives = 312/590 (52%), Gaps = 45/590 (7%)
 Frame = +1

Query: 184  HERKTVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQK------- 342
            H  K + L++ W  ++ GI ++            +   YM LYT +YN CT         
Sbjct: 10   HGLKQIGLDQIWDDLRAGIQQVYT------RQSMAKSRYMELYTHVYNYCTSVHQSNQAR 63

Query: 343  ----PPHDYSQ------------QLYDKYRESFEEYISSMVLPSLREKHDEFMLRELVKR 474
                PP    +            +LY + +E  + Y++++ L    +  DE +L+   ++
Sbjct: 64   GAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNL-LKDGEDLMDESVLKFYTQQ 122

Query: 475  WSNHKVMVRWLSRFFHYLDRYFI------SRRSLPALREVGLSCFRDLVYQEIKGKVKSA 636
            W +++   + L+    YL+R+++       R+ +  +  + L  +RD +++ +  +V +A
Sbjct: 123  WEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNA 182

Query: 637  VISLIDQEREGEQIDRALLKNVLDIFVEIGLG---------SMECYENDFEDFLLKDTAD 789
            V+ LI++ER GE I+  L+  V+  +VE+GL          ++  Y+  FE   L DT  
Sbjct: 183  VLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTER 242

Query: 790  YYSIKAQTWIVEDSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQ 969
            +Y+ ++  ++ ++   +YM KAE  L  E+ RV  YLH S++ +L  K +  L+ ++   
Sbjct: 243  FYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKH--- 299

Query: 970  LLEKEHSGCHALLRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDA 1149
             LE  H+    LL  DK EDL RMY L SRI  GL  + ++ + H+ N+G A +++  +A
Sbjct: 300  -LEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEA 358

Query: 1150 ASNKKPEKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKGV 1329
            A N             +++V+ ++++H KY A V   F     F  AL +A   F N   
Sbjct: 359  ALN-----------DPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNA 407

Query: 1330 ------SGSSSAELLATFCDNILKKGGSEKLSDEA-IEDTLEKVVRLLAYISDKDLFAEF 1488
                  S S S ELLA +CD++LKK  S K  +EA +EDTL +V+ +  YI DKD+F +F
Sbjct: 408  VTKMAQSSSKSPELLARYCDSLLKK--SSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKF 465

Query: 1489 YRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFI 1668
            Y K LA+RL+   SA+D+ E S+++KLKQ CG ++TSK++ M  D+ V++D   +F++ +
Sbjct: 466  YAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHL 525

Query: 1669 STHPELNPGIDLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFKEFYQTR 1818
            +    L+  +D ++ VL++G WP  +S    LP+E+ R  + F  FY +R
Sbjct: 526  TNSEPLD--LDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASR 573



 Score = 95.5 bits (236), Expect = 1e-18
 Identities = 64/212 (30%), Positives = 100/212 (47%), Gaps = 7/212 (3%)
 Frame = +2

Query: 1790 RFSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSE 1969
            RF+  +  +   +KLTW+Y L    +          L  +T+Q A+LL +N  D  +  +
Sbjct: 565  RFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQ 624

Query: 1970 IVTQLNLSDDDVVRLLHSLSCAKYKILTKEPSNRS---ISPNDVFEFNSKFTDKMRRIKI 2140
            +     +  D + ++L  L  +K  +L  E +N     + P+ + +    + +K  R+ I
Sbjct: 625  LTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNI 684

Query: 2141 PLP----PXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKP 2308
             +P                   R+  I A+IVRIMK RKVL HQ L+ E + QL   FKP
Sbjct: 685  NVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKP 744

Query: 2309 DFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
                IKK I+ LI ++YLER     + Y YLA
Sbjct: 745  RVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776

---

>Q13616:CUL1_HUMAN Cullin-1 - Homo sapiens (Human)|
          Length = 776

 Score =  280 bits (717), Expect = 2e-74
 Identities = 181/590 (30%), Positives = 312/590 (52%), Gaps = 45/590 (7%)
 Frame = +1

Query: 184  HERKTVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQK------- 342
            H  K + L++ W  ++ GI ++            +   YM LYT +YN CT         
Sbjct: 10   HGLKQIGLDQIWDDLRAGIQQVYT------RQSMAKSRYMELYTHVYNYCTSVHQSNQAR 63

Query: 343  ----PPHDYSQ------------QLYDKYRESFEEYISSMVLPSLREKHDEFMLRELVKR 474
                PP    +            +LY + +E  + Y++++ L    +  DE +L+   ++
Sbjct: 64   GAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNL-LKDGEDLMDESVLKFYTQQ 122

Query: 475  WSNHKVMVRWLSRFFHYLDRYFI------SRRSLPALREVGLSCFRDLVYQEIKGKVKSA 636
            W +++   + L+    YL+R+++       R+ +  +  + L  +RD +++ +  +V +A
Sbjct: 123  WEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNA 182

Query: 637  VISLIDQEREGEQIDRALLKNVLDIFVEIGLG---------SMECYENDFEDFLLKDTAD 789
            V+ LI++ER GE I+  L+  V+  +VE+GL          ++  Y+  FE   L DT  
Sbjct: 183  VLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTER 242

Query: 790  YYSIKAQTWIVEDSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQ 969
            +Y+ ++  ++ ++   +YM KAE  L  E+ RV  YLH S++ +L  K +  L+ ++   
Sbjct: 243  FYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKH--- 299

Query: 970  LLEKEHSGCHALLRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDA 1149
             LE  H+    LL  DK EDL RMY L SRI  GL  + ++ + H+ N+G A +++  +A
Sbjct: 300  -LEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEA 358

Query: 1150 ASNKKPEKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKGV 1329
            A N             +++V+ ++++H KY A V   F     F  AL +A   F N   
Sbjct: 359  ALN-----------DPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNA 407

Query: 1330 ------SGSSSAELLATFCDNILKKGGSEKLSDEA-IEDTLEKVVRLLAYISDKDLFAEF 1488
                  S S S ELLA +CD++LKK  S K  +EA +EDTL +V+ +  YI DKD+F +F
Sbjct: 408  VTKMAQSSSKSPELLARYCDSLLKK--SSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKF 465

Query: 1489 YRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFI 1668
            Y K LA+RL+   SA+D+ E S+++KLKQ CG ++TSK++ M  D+ V++D   +F++ +
Sbjct: 466  YAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHL 525

Query: 1669 STHPELNPGIDLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFKEFYQTR 1818
            +    L+  +D ++ VL++G WP  +S    LP+E+ R  + F  FY +R
Sbjct: 526  TNSEPLD--LDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASR 573



 Score = 95.5 bits (236), Expect = 1e-18
 Identities = 64/212 (30%), Positives = 100/212 (47%), Gaps = 7/212 (3%)
 Frame = +2

Query: 1790 RFSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSE 1969
            RF+  +  +   +KLTW+Y L    +          L  +T+Q A+LL +N  D  +  +
Sbjct: 565  RFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQ 624

Query: 1970 IVTQLNLSDDDVVRLLHSLSCAKYKILTKEPSNRS---ISPNDVFEFNSKFTDKMRRIKI 2140
            +     +  D + ++L  L  +K  +L  E +N     + P+ + +    + +K  R+ I
Sbjct: 625  LTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNI 684

Query: 2141 PLP----PXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKP 2308
             +P                   R+  I A+IVRIMK RKVL HQ L+ E + QL   FKP
Sbjct: 685  NVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKP 744

Query: 2309 DFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
                IKK I+ LI ++YLER     + Y YLA
Sbjct: 745  RVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776

---

>Q21346:CUL6_CAEEL Cullin-6 - Caenorhabditis elegans|
          Length = 729

 Score =  192 bits (489), Expect(2) = 9e-67
 Identities = 151/565 (26%), Positives = 264/565 (46%), Gaps = 28/565 (4%)
 Frame = +1

Query: 199  VDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCT--------QKPPHD 354
            + +E  W  +Q G+  L            S + YMMLY  +YN+CT           P  
Sbjct: 1    MSIEAVWGTLQDGLNLLYR------REHMSKKYYMMLYDAVYNICTTTTLANSNNNSPEF 54

Query: 355  YSQQLYDKYRESFEEYISSMVLPSLREK----HDEFMLRELVKRWSNHKVMVRWLSRFFH 522
             S+ LY    +  E YI + V+ ++R++      + +L +    W N K   R  +  F 
Sbjct: 55   ASEFLY----KQLENYIRTYVI-AIRDRISACSGDELLGKCTIEWDNFKFSTRICNCIFQ 109

Query: 523  YLDRYFISRR------SLPALREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQIDR 684
            YL+R F+S++       +  + ++ L  ++   +   K K   A++ LI  ER G  I+ 
Sbjct: 110  YLNRNFVSKKVEDKNGEIVEIYKLALDIWKAEFFDNFKVKTIDAILELILLERCGSTINS 169

Query: 685  ALLKNVLDIFVEIGLGSMECYENDFEDFLLKDTADYYSIKAQTWIVEDSCPDYMLKAEEC 864
              + +V++   E+ +     Y+  FE   L  T  +Y  K +    +++  +YM+  E  
Sbjct: 170  THISSVVECLTELDI-----YKVSFEPQFLDATKLFY--KQEVLNSKETVIEYMITVENR 222

Query: 865  LKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVEDLSRMY 1044
            L +E+ R   YL  S+   L++  +  L+    S  L+  HS    LL   K E L+RMY
Sbjct: 223  LFQEEYRSRRYLGPSTNDLLIDSCESILI----SDRLKFLHSEFERLLEARKDEHLTRMY 278

Query: 1045 RLFSRITRGLEPVSQIFKQHVTNEG-TALVKQAEDAASNKKPEKKDIVGLQEQVFVRKII 1221
             L  R+T GLE +    ++ +  EG   L + A+D+     P++          ++ K++
Sbjct: 279  SLCRRVTHGLEDLRVYLEKRILKEGHETLQRLAKDSGLKTTPKE----------YITKLL 328

Query: 1222 ELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKGV---------SGSSSAELLATFCDN 1374
            E+H+ Y   +   F  + LF ++L +A + F                + SA+ LA +CD 
Sbjct: 329  EVHEIYFNLINKAFDRNALFMQSLDKASKDFIEANAVTMLAPEKHRSTRSADYLARYCDQ 388

Query: 1375 ILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERS 1554
            +LKK  + K+ DE     L+K + +L YIS+KD+F  +Y+   + R++ + SA+D+ E  
Sbjct: 389  LLKK--NSKVQDET---ALDKALTVLKYISEKDVFQLYYQNWFSERIINNSSASDDAEEK 443

Query: 1555 ILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNPGIDLAVTVLTTGFW 1734
             +T L    G ++T  +  MV D  +++D  T+F++      +    ID  V + TTG W
Sbjct: 444  FITNLTATEGLEYTRNLVKMVEDAKISKDLTTEFKDI-----KTEKSIDFNVILQTTGAW 498

Query: 1735 PTYKSFDINLPAEMVRCVEVFKEFY 1809
            P+     I LP E+   ++ F  FY
Sbjct: 499  PSLDQIKIILPRELSTILKEFDTFY 523



 Score = 84.3 bits (207), Expect(2) = 9e-67
 Identities = 60/200 (30%), Positives = 89/200 (44%), Gaps = 7/200 (3%)
 Frame = +2

Query: 1826 KKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEIVTQLNLSDDDV 2005
            ++L W YS     + +K   K    IVT  Q   L LFN  D  +  +I   + ++    
Sbjct: 530  RRLNWAYSQCRGEVNSKAFEKKYVFIVTASQLCTLYLFNEQDSFTIEQISKAIEMTAKST 589

Query: 2006 VRLLHSLSCAKYKILTKEPSNRS--ISPNDVFEFNSKFTDKMRRIKIPLP-----PXXXX 2164
              ++ SL+     +L  +  N      P+ V   N+K+ +K  R+ +             
Sbjct: 590  SAIVGSLNPVIDPVLVVDKGNEKDGYPPDAVVSLNTKYANKKVRVDLTTAIKKATADRET 649

Query: 2165 XXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPDFKAIKKRIEDL 2344
                      R+Y I A IVRIMK+RK L H  L+ E + QL   F P+ + IK  IE L
Sbjct: 650  DAVQNTVESDRKYEIKACIVRIMKTRKSLTHTLLINEIISQLKSRFTPNVQMIKICIEIL 709

Query: 2345 ITRDYLERDKENPNVYRYLA 2404
            I + Y+ R +   NVY YLA
Sbjct: 710  IEQLYIRRSENEHNVYEYLA 729

---

>Q17390:CUL2_CAEEL Cullin-2 - Caenorhabditis elegans|
          Length = 776

 Score =  183 bits (464), Expect(2) = 1e-65
 Identities = 138/557 (24%), Positives = 263/557 (47%), Gaps = 42/557 (7%)
 Frame = +1

Query: 193  KTVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQLY 372
            K V+ ++ W  ++  I  + N+   +P    ++  +   ++ +Y++C   P    S++LY
Sbjct: 7    KVVEFDKVWVQLRPSIIDIINL---RP---ITNVQWHHKFSDVYDICVSIPT-PLSERLY 59

Query: 373  DKYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRR 552
            ++ +   +E++       + +   + +L+E  K W        ++ R F YL++ F+ ++
Sbjct: 60   NEVKACIQEHVRQK-RQDIVDVDPDLLLQEYHKMWRVFHEGAIFIHRLFGYLNKQFVKQK 118

Query: 553  ---------------SLPALREVG---LSCFRDLVYQEIKGKVKSAVISLIDQEREGEQI 678
                            +P ++E+G   L  +++ + + I  ++   ++  ID +R+G   
Sbjct: 119  RCTDLDNFAQYAAFLQIPDVKEIGCLALEIWKEDLVKTILPQLVKLLLIAIDNDRKGNFP 178

Query: 679  DRAL-LKNVLDIFVEIGLGSMEC-----------------YENDFEDFLLKDTADYYSIK 804
              A  +  V++ FV++     +                  Y+  FE  LL DT  YYS  
Sbjct: 179  HIANEVSGVINSFVKMEETDFDVVPAEGARYKARESTTAFYQESFEKPLLTDTEQYYSAL 238

Query: 805  AQTWIVEDSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKE 984
            AQ  + + SC +YM +    L++E+ R   YLH SS  K++   Q  ++  +  +L    
Sbjct: 239  AQKMLTDLSCSEYMEQVIVLLEQEEMRAKKYLHESSVEKVITLCQKVMIKAHKDKL---- 294

Query: 985  HSGCHALLRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKK 1164
            H+ CH L+ +++ +DL  MYRL   I  GL  + + F+++V  +G   V +         
Sbjct: 295  HAVCHDLITNEENKDLRNMYRLLKPIQAGLSVMVKEFEEYVKKKGLEAVSRL---TGENV 351

Query: 1165 PEKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKGVSGSS- 1341
            P++          FV  ++ +++K+    T  F     F   L +A +   N    G S 
Sbjct: 352  PQQ----------FVENVLRVYNKFNDMKTAVFMDDGEFSSGLDKALQGVVNSKEPGQSV 401

Query: 1342 --SAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRL 1515
              ++E LA + D +LKK  ++ LS+  +E  L+  + +  YI DKD+F +FY K LA RL
Sbjct: 402  PKASERLARYTDGLLKKS-TKGLSETDLEAKLDSAIVIFRYIEDKDIFQKFYSKMLANRL 460

Query: 1516 LFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNPG 1695
            +   S + + E  ++ KLKQ CG +FTSK+  M TD+ ++++    F++ I+    + P 
Sbjct: 461  IASTSISMDAEELMINKLKQACGYEFTSKLSRMFTDIGLSQELSNNFDKHIADIKTVQPD 520

Query: 1696 IDLAVT---VLTTGFWP 1737
            +    T   +L  G WP
Sbjct: 521  VKFVPTQTMILQAGSWP 537



 Score = 90.1 bits (222), Expect(2) = 1e-65
 Identities = 59/214 (27%), Positives = 103/214 (48%), Gaps = 7/214 (3%)
 Frame = +2

Query: 1784 VSRFSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSY 1963
            +  F K +  +   +KLTW++++    +   +  K     +  YQ A LL F   D +  
Sbjct: 568  IQEFEKFYTGKHNGRKLTWLFNMSQGDVRLTYLDKQYVAQMYVYQMAALLCFERRDAILV 627

Query: 1964 SEIVTQLNLSDDDVVRLLHSLSCAKYKILTKEPSNRSISPNDVFEFNSKFTDKMRRIKIP 2143
             +I  ++ +S D +++ + ++      +LT +  N  ++ + +   N   T K  + ++ 
Sbjct: 628  KDIGEEIGVSGDYLLKTIRTI--LDVTLLTCDDQN--LTADSLVRLNMSMTSKRMKFRLQ 683

Query: 2144 LPPXXXXXXXXXXXXXX-------RRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMF 2302
             P                      R+Y ++ +IVRIMK+RKVL H  LV E ++Q    F
Sbjct: 684  APQVNKAVEKEQEAVANTFQVSQDRKYYMECAIVRIMKTRKVLKHNALVTEIMDQTKGRF 743

Query: 2303 KPDFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
             PD   IKK IEDLI + Y++R  +N + Y+YLA
Sbjct: 744  SPDVPFIKKSIEDLIEKMYIQRTDQN-DEYQYLA 776

---

>Q24311:CUL1_DROME Cullin homolog 1 - Drosophila melanogaster (Fruit fly)|
          Length = 774

 Score =  248 bits (632), Expect = 1e-64
 Identities = 163/582 (28%), Positives = 296/582 (50%), Gaps = 39/582 (6%)
 Frame = +1

Query: 190  RKTVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQ--KPPHDYS- 360
            +K V+L++ W+ + +GI ++      + E   +   YM  YT +Y+ CT     P   S 
Sbjct: 11   QKLVNLDDIWSELVEGIMQVF-----EHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSS 65

Query: 361  ----------QQLYDKYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLS 510
                      ++LYD+  +  + Y+S ++        +E +L    K+W +++     L 
Sbjct: 66   GKTGGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLD 125

Query: 511  RFFHYLDRYFISR------RSLPALREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGE 672
               +YL+R ++ R      + +  +  + L  ++  ++Q +   V  AV+  I++ER+G+
Sbjct: 126  GICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGK 185

Query: 673  QIDRALLKNVLDIFVEIGLGS---------MECYENDFEDFLLKDTADYYSIKAQTWIVE 825
             I+R+L+++V++ +VE+             +  Y+ +FE+  + DT+ +Y  ++  ++  
Sbjct: 186  LINRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLST 245

Query: 826  DSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKE----HSG 993
            ++  +Y+   E  L+ E +RV  +   +    L E     L +     L+EK     H+ 
Sbjct: 246  NTVTEYLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTE 305

Query: 994  CHALLRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQA--EDAASNKKP 1167
               LL  D+ +DL RMY L +  ++ L  +  I + H+ ++GT  + +    DAA++ K 
Sbjct: 306  FQNLLNADRNDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPK- 364

Query: 1168 EKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKGV-----S 1332
                        +V+ I+++H KY A V   F     F  AL +A   F N  V     S
Sbjct: 365  -----------TYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANS 413

Query: 1333 GSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARR 1512
             S S ELLA +CD +LKK  S+   D+ +ED L +V+ +  YI DKD+F ++Y K LA+R
Sbjct: 414  ASKSPELLAKYCDLLLKKS-SKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKR 472

Query: 1513 LLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNP 1692
            L+   SA+D+ E  +++KLKQ CG ++T K++ M  D+ V++D  + F+++++    L  
Sbjct: 473  LVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLA-EKNLTM 531

Query: 1693 GIDLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFKEFYQTR 1818
             ID  + VL++G WP   S +  LP+E+ R V  F EFY  R
Sbjct: 532  EIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAAR 573



 Score = 95.1 bits (235), Expect = 1e-18
 Identities = 63/214 (29%), Positives = 103/214 (48%), Gaps = 7/214 (3%)
 Frame = +2

Query: 1784 VSRFSKSFIKQELSKKLTWIYSL---GICHITAKFEAKTIELIVTTYQAALLLLFNGADK 1954
            V +F++ +  +   +KL W+Y +    +     +  + T  L  +T+Q ++LL FN    
Sbjct: 563  VRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLS 622

Query: 1955 LSYSEIVTQLNLSDDDVVRLLHSLSCAKYKILTKEPSNRSISPNDVFEFNSKFTDKMRRI 2134
             +  ++        ++++++L  L   K K+LT   +  S++P    E    + +K RRI
Sbjct: 623  FTVQQLQDNTQTQQENLIQVLQIL--LKAKVLTSSDNENSLTPESTVELFLDYKNKKRRI 680

Query: 2135 KIPLPPXXXXXXXXXXXXXX----RRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMF 2302
             I  P                   R+  I A+IVRIMK RK L H  L+ E + QL   F
Sbjct: 681  NINQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRF 740

Query: 2303 KPDFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
            KP    IKK I+ LI ++YLER + + + Y YLA
Sbjct: 741  KPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774

---

>Q17392:CUL4_CAEEL Cullin-4 - Caenorhabditis elegans|
          Length = 840

 Score =  147 bits (371), Expect(2) = 2e-57
 Identities = 117/525 (22%), Positives = 239/525 (45%), Gaps = 21/525 (4%)
 Frame = +1

Query: 307  LYTTIYNMCTQKPPHDYSQQLYDK-------YRESFEEYISSMVLPSLREKHDEFMLREL 465
            L++ + ++C +    + S+ LYD+       + +S +E ++++    L E + E  L + 
Sbjct: 145  LFSKVRSVCDK----NQSKVLYDRLVAIVVQFAKSLKESLNAVEQVPLAEDNCEQYLEKF 200

Query: 466  VKRWSNHKVMVRWLSRFFHYLDRYFISRRSLPAL------REVGLSCFRDLVYQEIKG-K 624
             + W  + V +  +   F +LDR  +       L       ++    F   +++E K  K
Sbjct: 201  GQIWQAYPVKINLIRNIFLHLDRIALGATDTEILPLWECFMQIFQKTFFPNIFKEFKATK 260

Query: 625  VKSAVISLIDQEREGEQIDRALLKNVLDIFVEIGLGSMECYENDFEDFLLKDTADYYSIK 804
            + +A+   + +  +   +D  L ++++D+   + +        +F  FL+    ++Y+ +
Sbjct: 261  LFNALYMAMQKIMQRYPVDSPL-RSLVDMLQTVHVSE------EFAKFLISQLREHYNNE 313

Query: 805  AQTWIVEDSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHE----LLTQYASQL 972
                + + +C DYM   E+ + R  + V     +  EP  L+ VQ      L+ Q   ++
Sbjct: 314  RIDKVPKMNCNDYMEYCEDQINRYSQLVKV---NFDEPSALKDVQATVTNCLIQQAIPEI 370

Query: 973  LEKEHSGCHALLRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAA 1152
            L  +      L+  D + D+ RM+ L  +   G + V   F +++   G  L+    D  
Sbjct: 371  LTHDFDD---LIDSDNISDIGRMFNLCRQCVGGEDEVRTQFSKYLKKRGEKLIATCPD-- 425

Query: 1153 SNKKPEKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHT---LFHKALKEAFEVFCNK 1323
                           +  V +++    K    +T  F+         + L +AFE F NK
Sbjct: 426  ---------------EDLVSELLAFKKKVDFIMTGSFKSANDPVKMRQCLSDAFESFVNK 470

Query: 1324 GVSGSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKL 1503
             V    SAEL++     +L         D  ++  +++ + L  Y+  KD+F  +Y++ L
Sbjct: 471  QVD--RSAELISKHFHTLLHSSNKNVSDDTTLDQMVDEAIVLFRYLRGKDVFEAYYKRGL 528

Query: 1504 ARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPE 1683
            A+RL  ++SA+ + E+ +L KLK +CG  FT K+EGM  D+  + ++   F +++  H  
Sbjct: 529  AKRLFLERSASVDAEKMVLCKLKTECGSAFTYKLEGMFKDMDASENYGRLFNQYLE-HMN 587

Query: 1684 LNPGIDLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFKEFYQTR 1818
                 +    V+T  +WPTY +++IN+P EM   +  +++FY+ +
Sbjct: 588  KEKA-NFTARVITPEYWPTYDTYEINIPKEMRDTLTDYQDFYRVQ 631



 Score = 98.6 bits (244), Expect(2) = 2e-57
 Identities = 73/212 (34%), Positives = 106/212 (50%), Gaps = 15/212 (7%)
 Frame = +2

Query: 1814 QELSKKLTWIYSLGICHITAKFEAKTI-ELIVTTYQAALLLLFNGADKLSYSEIVTQLNL 1990
            Q  ++ + W + L    I+A F      ELI T YQ  +LLLFN  +  + +EIV    +
Sbjct: 631  QHGNRNVKWHHGLASAVISASFRPGCKKELIATMYQTVILLLFNKCETWTVAEIVEHTKI 690

Query: 1991 SDDDVVRLLHSLSCA--KYKILTKEPSNRSISP--------NDVFEFNSKFTDKMRRIKI 2140
             + +VV+ + +L     K K+L +     S           N+ F  NSKFT+K  R++I
Sbjct: 691  LEIEVVKNVLALLGGRDKPKVLQRVEGGGSEKKEGTVENLKNEKFVVNSKFTEKRCRVRI 750

Query: 2141 PL----PPXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKP 2308
                                  R+Y IDA++VRIMK+RK L HQTL+ E ++QL   F  
Sbjct: 751  AQVNIKTAVEETKEVKEEVNSDRQYKIDAAVVRIMKARKQLNHQTLMTELLQQL--RFPV 808

Query: 2309 DFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
                IKKR+E LI R+Y+ RD E  + Y Y+A
Sbjct: 809  STADIKKRLESLIEREYISRDPEEASSYNYVA 840

---

>Q09760:CUL3_SCHPO Cullin-3 - Schizosaccharomyces pombe (Fission yeast)|
          Length = 785

 Score =  197 bits (501), Expect = 2e-49
 Identities = 147/578 (25%), Positives = 271/578 (46%), Gaps = 38/578 (6%)
 Frame = +1

Query: 199  VDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQLYDK 378
            VD    W  +Q+ I  +      K   Q S E+   LY   Y +      H Y ++LY+ 
Sbjct: 20   VDFATHWEVLQRAIGDIFQ----KSTSQLSFEE---LYRNAYILVL----HKYGEKLYNH 68

Query: 379  YRESFEEYISSMVLPSLREKHDEFML----------------------------RELVKR 474
             ++     +    +P++ + +D  +L                              LV  
Sbjct: 69   VQDVIRSRLKEETVPAIYKNYDASLLGNALLDIRKNDSYSTSWSRSLEAAHRFLSSLVNS 128

Query: 475  WSNHKVMVRWLSRFFHYLDRYFISRRSLPALREVGLSCFRDLVYQ---EIKGKVKSAVIS 645
            W +H V ++ +S    YLD+ +        + E G+  FR++V     EI  K    ++ 
Sbjct: 129  WKDHIVSMQMISSVLKYLDKVYSKSADKVPVNENGIYIFREVVLLNSFEIGEKCVETILI 188

Query: 646  LIDQEREGEQIDRALLKNVLDIFVEIGLGSME--CYENDFEDFLLKDTADYYSIKAQTWI 819
            L+  ER+G  I+R L+ + LD+   +   + +   Y+  F    L  T ++Y I++ T I
Sbjct: 189  LVYLERKGNTINRPLINDCLDMLNSLPSENKKETLYDVLFAPKFLSYTRNFYEIESSTVI 248

Query: 820  VEDSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCH 999
                  +Y+ KAE+  + EKER  +YL +     LL  V+ ELL+++   LLE + +G  
Sbjct: 249  GVFGVVEYLKKAEKRFEEEKERSKNYLFTKIASPLLSVVEDELLSKHLDDLLENQSTGFF 308

Query: 1000 ALLRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKKPEKK- 1176
            +++     E L  +Y  FSR+  G++ + +   ++V + G  + +    A   K    + 
Sbjct: 309  SMIDSSNFEGLQLVYESFSRVELGVKSLKKYLAKYVAHHGKLINETTSQALEGKMAVGRL 368

Query: 1177 DIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKGVSGSSSA-EL 1353
                    ++V+K++ L D+    ++           +L +AF  F    V G + A E 
Sbjct: 369  SSNATMATLWVQKVLALWDRLNTIISTTMDADRSILNSLSDAFVTF----VDGYTRAPEY 424

Query: 1354 LATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSA 1533
            ++ F D+ LKK  + K  + +IE TL+  V L  +IS+KD+F ++Y+  LA+RLL ++S 
Sbjct: 425  ISLFIDDNLKKD-ARKAIEGSIEATLQNSVTLFRFISEKDVFEKYYKTHLAKRLLNNRSI 483

Query: 1534 NDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNPGIDLAVT 1713
            + + E  ++++LKQ+ G  FT K+EGM  D+ ++++   +++   S      P +DL V+
Sbjct: 484  SSDAELGMISRLKQEAGNVFTQKLEGMFNDMNLSQELLQEYKH-NSALQSAKPALDLNVS 542

Query: 1714 VLTTGFWPTYKS---FDINLPAEMVRCVEVFKEFYQTR 1818
            +L + FWP   S      N P  ++  ++ F +FY ++
Sbjct: 543  ILASTFWPIDLSPHKIKCNFPKVLLAQIDQFTDFYLSK 580



 Score =  134 bits (336), Expect = 3e-30
 Identities = 76/216 (35%), Positives = 112/216 (51%), Gaps = 9/216 (4%)
 Frame = +2

Query: 1784 VSRFSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADK--- 1954
            + +F+  ++ +   +KL W  S+G   +   F+ +  +L V+T  + +LLLF    +   
Sbjct: 570  IDQFTDFYLSKHTGRKLLWYPSMGSADVRVNFKDRKYDLNVSTIASVILLLFQDLKENQC 629

Query: 1955 LSYSEIVTQLNLSDDDVVRLLHSLSCAKYKILTKEPSNRSISPNDVFEFNSKFTDKMRRI 2134
            L + EI+ + N+   D+ R L SL+CAKYKIL K+P  R ++  D F FN  F   + RI
Sbjct: 630  LIFEEILEKTNIEVGDLKRNLQSLACAKYKILLKDPKGREVNAGDKFYFNENFVSNLARI 689

Query: 2135 KIP------LPPXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGR 2296
            KI       +                R++  DA IVR+MK RKV  H  L+ E   QL  
Sbjct: 690  KISTVAQTRVEDDSERKRTLEKVDESRKHQADACIVRVMKDRKVCEHNQLMAEVTRQLNP 749

Query: 2297 MFKPDFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
             F P    IK+RIE LI R+YL+R  +N  +Y YLA
Sbjct: 750  RFHPSPMMIKRRIEALIEREYLQRQADNGRIYEYLA 785

---

>Q9D5V5:CUL5_MOUSE Cullin-5 - Mus musculus (Mouse)|
          Length = 780

 Score =  171 bits (432), Expect = 2e-41
 Identities = 127/572 (22%), Positives = 262/572 (45%), Gaps = 33/572 (5%)
 Frame = +1

Query: 196  TVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQLYD 375
            ++  E+ W FM   + KL        +   + + +  L++ ++ +C        S +++ 
Sbjct: 12   SLQFEDKWDFMHPIVLKLLR------QESVTKQQWFDLFSDVHAVCLWDDKG--SSKIHQ 63

Query: 376  KYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRRS 555
              +E   E+I       L  + D  +L+  +  W         L + F  L+   + ++S
Sbjct: 64   ALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEVTLLGKQS 123

Query: 556  L--------PALREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQIDRALLKNVLDI 711
                       +R++ L  + + ++  IK +++ + + L+  ER GE  D  L+  V + 
Sbjct: 124  SNKKSNMEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRES 183

Query: 712  FVEIGLG---SMECYENDFEDFLLKDTADYYSIKAQTWIVEDSCPDYMLKAEECLKREKE 882
            +V +       ++ Y ++FE   L  T  +Y  +A +++ ++   +YM  A+  LK E++
Sbjct: 184  YVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEK 243

Query: 883  RVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFSRI 1062
            R   YL +  E   +E +    +    +   E   + C  +++ ++ E L  M+ L  ++
Sbjct: 244  RALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKV 303

Query: 1063 TRGLEPVSQIFKQHVTNEGTA-LVKQAEDAASNKKPEKKDIVGLQEQVFVRKIIELHDKY 1239
              G+EP+ +  ++H+ + G A +V  AE   ++             + +V +++ L +++
Sbjct: 304  PNGIEPMLKDLEEHIISAGLADMVAAAETITTD------------SEKYVEQLLTLFNRF 351

Query: 1240 VAYVTDCFQGHTLFHKALKEAFEVFCN-------------KGVS-----GSSSAELLATF 1365
               V + FQ    F  A  +A++   N             KGV       S   ELLA +
Sbjct: 352  SKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANY 411

Query: 1366 CDNILKKGG-SEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDE 1542
            CD +L+K   S+KL+ E IE  L++V+ +L Y+ +KD+F  +++  L RRL+ D SA+ E
Sbjct: 412  CDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSE 471

Query: 1543 HERSILTKLKQ-QCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNPGIDLAVTVL 1719
             E +++  L++      + +K+  M  D+ V+ D    F+E    +    P   + + +L
Sbjct: 472  IEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKIL 531

Query: 1720 TTGFWP-TYKSFDINLPAEMVRCVEVFKEFYQ 1812
              G W  + +   ++LP E+   +   +EFY+
Sbjct: 532  NAGAWSRSSEKVFVSLPTELEDLIPEVEEFYK 563



 Score = 69.3 bits (168), Expect = 8e-11
 Identities = 64/227 (28%), Positives = 101/227 (44%), Gaps = 19/227 (8%)
 Frame = +2

Query: 1781 DVSRFSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGA--DK 1954
            +V  F K   K    +KL W + +    IT K E    +L VTT+Q A+L  +N    +K
Sbjct: 557  EVEEFYK---KNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREK 613

Query: 1955 LSYSEIVTQLNLSDDDVVRLLHSLSC---AKYKILTKEP---SNRSISPNDVFEFNSKFT 2116
            +S+  +     L D ++ R L SL      K ++L  +P   S +  +   +F  N  F+
Sbjct: 614  ISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEGTLFSVNQDFS 673

Query: 2117 -------DKMRRI----KIPLPPXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQT 2263
                    K  +I    ++ L                R      +I++IMK RK + +  
Sbjct: 674  LIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQ 733

Query: 2264 LVMECVEQLGRMFKPDFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
            L  E VE L  MF P  K IK+++E LI   Y+ RD+ + N + Y+A
Sbjct: 734  LQTELVEILKNMFLPQKKMIKEQMEWLIEHRYIRRDEADINTFIYMA 780

---

>Q9JJ31:CUL5_RAT Cullin-5 - Rattus norvegicus (Rat)|
          Length = 780

 Score =  170 bits (431), Expect = 3e-41
 Identities = 127/572 (22%), Positives = 263/572 (45%), Gaps = 33/572 (5%)
 Frame = +1

Query: 196  TVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCTQKPPHDYSQQLYD 375
            ++  E+ W FM+  + KL        +   + + +  L++ ++ +C        S +++ 
Sbjct: 12   SLQFEDKWDFMRPIVLKLLR------QESVTKQQWFDLFSDVHAVCLWDDKG--SSKIHQ 63

Query: 376  KYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRRS 555
              +E   E+I       L  + D  +L+  +  W         L + F  L+   + ++S
Sbjct: 64   ALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEVTLLGKQS 123

Query: 556  L--------PALREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQIDRALLKNVLDI 711
                       +R++ L  + + ++  IK +++ + + L+  ER GE  D  L+  V + 
Sbjct: 124  SNKKSNMEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRES 183

Query: 712  FVEIGLG---SMECYENDFEDFLLKDTADYYSIKAQTWIVEDSCPDYMLKAEECLKREKE 882
            +V +       ++ Y ++FE   L  T  +Y  +A +++ ++   +YM  A+  LK E++
Sbjct: 184  YVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEK 243

Query: 883  RVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFSRI 1062
            R   YL +  E   +E +    +    +   E   + C  +++ ++ E L  M+ L  ++
Sbjct: 244  RALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKV 303

Query: 1063 TRGLEPVSQIFKQHVTNEGTA-LVKQAEDAASNKKPEKKDIVGLQEQVFVRKIIELHDKY 1239
              G+EP+ +  ++H+ + G A +V  AE   ++             + +V +++ L +++
Sbjct: 304  PGGIEPMLKDLEEHIISAGLADMVAAAETITTD------------SEKYVEQLLTLFNRF 351

Query: 1240 VAYVTDCFQGHTLFHKALKEAFEVFCN-------------KGVS-----GSSSAELLATF 1365
               V + FQ    F  A  +A++   N             KGV       S   ELLA +
Sbjct: 352  SKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANY 411

Query: 1366 CDNILKKGG-SEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDE 1542
            CD +L+K   S+KL+ E IE  L++V+ +L Y+ +KD+F  +++  L RRL+ D SA+ E
Sbjct: 412  CDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSE 471

Query: 1543 HERSILTKLKQ-QCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNPGIDLAVTVL 1719
             E +++  L++      + +K+  M  D+ V+ D    F+E    +    P   + + +L
Sbjct: 472  IEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKIL 531

Query: 1720 TTGFWP-TYKSFDINLPAEMVRCVEVFKEFYQ 1812
              G W  + +   ++LP E+   +   +EFY+
Sbjct: 532  NAGAWSRSSEKVFVSLPTELEDLIPEVEEFYK 563



 Score = 70.9 bits (172), Expect = 3e-11
 Identities = 65/227 (28%), Positives = 101/227 (44%), Gaps = 19/227 (8%)
 Frame = +2

Query: 1781 DVSRFSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGA--DK 1954
            +V  F K   K    +KL W + +    IT K E    +L VTT+Q A+L  +N    +K
Sbjct: 557  EVEEFYK---KNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREK 613

Query: 1955 LSYSEIVTQLNLSDDDVVRLLHSLSC---AKYKILTKEP---SNRSISPNDVFEFNSKFT 2116
            +S+  +     L D ++ R L SL      K ++L  +P   S +  +   +F  N  F+
Sbjct: 614  ISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEGTLFSVNQDFS 673

Query: 2117 -------DKMRRI----KIPLPPXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQT 2263
                    K  +I    ++ L                R      +I++IMK RK + +  
Sbjct: 674  LIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQ 733

Query: 2264 LVMECVEQLGRMFKPDFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
            L  E VE L  MF P  K IK++IE LI   Y+ RD+ + N + Y+A
Sbjct: 734  LQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDEADINTFIYMA 780

---

>Q12018:CDC53_YEAST Cell division control protein 53 - Saccharomyces cerevisiae (Baker's|
            yeast)
          Length = 815

 Score =  169 bits (428), Expect = 6e-41
 Identities = 134/596 (22%), Positives = 261/596 (43%), Gaps = 57/596 (9%)
 Frame = +1

Query: 202  DLEEGWAFMQKGITKLKNILEGKPEPQ------FSSEDYMMLYTTIYNMCTQKPPHD--- 354
            DLE  W F++ GI ++    + +           S   YM +YT IYN C  K       
Sbjct: 10   DLEATWNFIEPGINQILGNEKNQASTSKRVYKILSPTMYMEVYTAIYNYCVNKSRSSGHF 69

Query: 355  ------------YSQQLYDKYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMV 498
                           ++Y+K +   + YI +      ++ + E  L+  VKRW    +  
Sbjct: 70   STDSRTGQSTILVGSEIYEKLKNYLKNYILNF-----KQSNSETFLQFYVKRWKRFTIGA 124

Query: 499  RWLSRFFHYLDRYFISRRSLPALREVG------LSCFRDLVYQEIKGKVKSAVISLIDQE 660
             +L+  F Y++RY++ +      R +       L  ++++++   K  + + ++  +   
Sbjct: 125  IFLNHAFDYMNRYWVQKERSDGKRHIFDVNTLCLMTWKEVMFDPSKDVLINELLDQVTLG 184

Query: 661  REGEQIDRALLKNVLDIFVEIGLG-------SMECYENDFEDFLLKDTADYYSIKAQTWI 819
            REG+ I R+ +   +   V +G+        ++  Y   FE   LK T +YY+     ++
Sbjct: 185  REGQIIQRSNISTAIKSLVALGIDPQDLKKLNLNVYIQVFEKPFLKKTQEYYTQYTNDYL 244

Query: 820  VEDSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCH 999
             + S  +Y+ +A E +KRE++ +  Y    ++  L   +   L+T +    +EK  +   
Sbjct: 245  EKHSVTEYIFEAHEIIKREEKAMTIYWDDHTKKPLSMALNKVLITDH----IEKLENEFV 300

Query: 1000 ALLRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGT-------ALVKQAEDAASN 1158
             LL    +E ++ +Y L  R    +  ++ +F+ +V   G        A+ K       N
Sbjct: 301  VLLDARDIEKITSLYALIRRDFTLIPRMASVFENYVKKTGENEISSLLAMHKHNIMKNEN 360

Query: 1159 KKPEKKDIV---GLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKGV 1329
              P+K  ++    L  + +++K++E+HD +     + F       KAL  A   F N   
Sbjct: 361  ANPKKLALMTAHSLSPKDYIKKLLEVHDIFSKIFNESFPDDIPLAKALDNACGAFININE 420

Query: 1330 ----------SGSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLF 1479
                      + S ++E+LA + D +LKK    +++ +  +   E ++ +  Y++DKD F
Sbjct: 421  FALPAGSPKSATSKTSEMLAKYSDILLKKATKPEVASDMSD---EDIITIFKYLTDKDAF 477

Query: 1480 AEFYRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFE 1659
               YR+  A+RL+   S + E E +I+ +L+     ++T K+  M  D+ +++  +  F 
Sbjct: 478  ETHYRRLFAKRLIHGTSTSAEDEENIIQRLQAANSMEYTGKITKMFQDIRLSKILEDDFA 537

Query: 1660 EFISTHPELNPG--IDLAVTVLTTGFWP-TYKSFDINLPAEMVRCVEVFKEFYQTR 1818
              +   P+ +     DL   VL    WP +Y+  +  LP E+V   E  KE Y  +
Sbjct: 538  VALKNEPDYSKAKYPDLQPFVLAENMWPFSYQEVEFKLPKELVPSHEKLKESYSQK 593



 Score = 58.9 bits (141), Expect = 1e-07
 Identities = 54/234 (23%), Positives = 96/234 (41%), Gaps = 29/234 (12%)
 Frame = +2

Query: 1790 RFSKSFIKQELSKKLTWIYSLGICHITA---KFEAKTIELIVTTYQAALLLLFNGADKLS 1960
            +  +S+ ++   + L W++ L    + A   K         VT +Q A+LLL+N AD L+
Sbjct: 585  KLKESYSQKHNGRILKWLWPLCRGELKADIGKPGRMPFNFTVTLFQMAILLLYNDADVLT 644

Query: 1961 YSEIVTQLNLSDDDVVRLLHSLSCAKYKILTKEPSNRS--ISPNDVFEFNSKFTDKMRRI 2134
               I    +L+   +   +  +   K+K++ + P      + P   F+ +  +      I
Sbjct: 645  LENIQEGTSLTIQHIAAAM--VPFIKFKLIQQVPPGLDALVKPETQFKLSRPYKALKTNI 702

Query: 2135 ------------------------KIPLPPXXXXXXXXXXXXXXRRYAIDASIVRIMKSR 2242
                                    K+                  R+  ++A IVRIMK++
Sbjct: 703  NFASGVKNDILQSLSGGGHDNHGNKLGNKRLTEDERIEKELNTERQIFLEACIVRIMKAK 762

Query: 2243 KVLGHQTLVMECVEQLGRMFKPDFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
            + L H TLV EC+ Q  + F      +K+ I+ LI + YL+R  +  + Y YLA
Sbjct: 763  RNLPHTTLVNECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQRGDDGES-YAYLA 815

---

>Q29425:CUL5_RABIT Cullin-5 - Oryctolagus cuniculus (Rabbit)|
          Length = 780

 Score =  168 bits (426), Expect = 1e-40
 Identities = 129/574 (22%), Positives = 262/574 (45%), Gaps = 35/574 (6%)
 Frame = +1

Query: 196  TVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCT--QKPPHDYSQQL 369
            ++  E+ W FM+  + KL        +   + + +  L++ ++ +C    K P    Q L
Sbjct: 12   SLQFEDKWDFMRPIVLKLLR------QESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQAL 65

Query: 370  YDKYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISR 549
                +E   E+I       L  + D  +L+  +  W         L + F  L+   + +
Sbjct: 66   ----KEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGK 121

Query: 550  RSL--------PALREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQIDRALLKNVL 705
            +            +R++ L  + + ++  IK +++ + + L+  ER GE  D  L+  V 
Sbjct: 122  QGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVR 181

Query: 706  DIFVEIGLG---SMECYENDFEDFLLKDTADYYSIKAQTWIVEDSCPDYMLKAEECLKRE 876
            + +V +       ++ Y ++FE   L  T  +Y  +A +++ ++   +YM  A+  LK E
Sbjct: 182  ESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEE 241

Query: 877  KERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFS 1056
            ++R   YL +  E   +E +    +    +   E   + C  +++ ++ E L  M+ L  
Sbjct: 242  EKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMD 301

Query: 1057 RITRGLEPVSQIFKQHVTNEGTA-LVKQAEDAASNKKPEKKDIVGLQEQVFVRKIIELHD 1233
            ++  G+EP+ +  ++H+ + G A +V  AE   ++             + +V +++ L +
Sbjct: 302  KVPNGIEPMLKDLEEHIISAGLADMVAAAETITTD------------SEKYVEQLLTLFN 349

Query: 1234 KYVAYVTDCFQGHTLFHKALKEAFEVFCN-------------KGVS-----GSSSAELLA 1359
            ++   V + FQ    F  A  +A++   N             KGV       S   ELLA
Sbjct: 350  RFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLA 409

Query: 1360 TFCDNILKKGG-SEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSAN 1536
             +CD +L+K   S+KL+ E IE  L++V+ +L Y+ +KD+F  +++  L RRL+ D SA+
Sbjct: 410  NYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISAD 469

Query: 1537 DEHERSILTKLKQ-QCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNPGIDLAVT 1713
             E E +++  L++      + +K+  M  D+ V+ D    F+E    +    P   + + 
Sbjct: 470  SEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIK 529

Query: 1714 VLTTGFWP-TYKSFDINLPAEMVRCVEVFKEFYQ 1812
            +L  G W  + +   ++LP E+   +   +EFY+
Sbjct: 530  ILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYK 563



 Score = 69.3 bits (168), Expect = 8e-11
 Identities = 65/227 (28%), Positives = 100/227 (44%), Gaps = 19/227 (8%)
 Frame = +2

Query: 1781 DVSRFSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFN--GADK 1954
            +V  F K   K    +KL W + +    IT K E    +L VTT+Q A+L  +N    +K
Sbjct: 557  EVEEFYK---KNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREK 613

Query: 1955 LSYSEIVTQLNLSDDDVVRLLHSLSC---AKYKILTKEP---SNRSISPNDVFEFNSKFT 2116
            +S+  +     L D ++ R L SL      K ++L  EP   S +  +   +F  N +F+
Sbjct: 614  ISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFS 673

Query: 2117 -------DKMRRI----KIPLPPXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQT 2263
                    K  +I    ++ L                R        ++IMK RK + +  
Sbjct: 674  LIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTRKLYIQIMKMRKKISNAQ 733

Query: 2264 LVMECVEQLGRMFKPDFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
            L  E VE L  MF P  K IK++IE LI   Y+ RD+ + N + Y+A
Sbjct: 734  LQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780

---

>Q93034:CUL5_HUMAN Cullin-5 - Homo sapiens (Human)|
          Length = 780

 Score =  168 bits (426), Expect = 1e-40
 Identities = 129/574 (22%), Positives = 262/574 (45%), Gaps = 35/574 (6%)
 Frame = +1

Query: 196  TVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCT--QKPPHDYSQQL 369
            ++  E+ W FM+  + KL        +   + + +  L++ ++ +C    K P    Q L
Sbjct: 12   SLQFEDKWDFMRPIVLKLLR------QESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQAL 65

Query: 370  YDKYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISR 549
                +E   E+I       L  + D  +L+  +  W         L + F  L+   + +
Sbjct: 66   ----KEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGK 121

Query: 550  RSL--------PALREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQIDRALLKNVL 705
            +            +R++ L  + + ++  IK +++ + + L+  ER GE  D  L+  V 
Sbjct: 122  QGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVR 181

Query: 706  DIFVEIGLG---SMECYENDFEDFLLKDTADYYSIKAQTWIVEDSCPDYMLKAEECLKRE 876
            + +V +       ++ Y ++FE   L  T  +Y  +A +++ ++   +YM  A+  LK E
Sbjct: 182  ESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEE 241

Query: 877  KERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFS 1056
            ++R   YL +  E   +E +    +    +   E   + C  +++ ++ E L  M+ L  
Sbjct: 242  EKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMD 301

Query: 1057 RITRGLEPVSQIFKQHVTNEGTA-LVKQAEDAASNKKPEKKDIVGLQEQVFVRKIIELHD 1233
            ++  G+EP+ +  ++H+ + G A +V  AE   ++             + +V +++ L +
Sbjct: 302  KVPNGIEPMLKDLEEHIISAGLADMVAAAETITTD------------SEKYVEQLLTLFN 349

Query: 1234 KYVAYVTDCFQGHTLFHKALKEAFEVFCN-------------KGVS-----GSSSAELLA 1359
            ++   V + FQ    F  A  +A++   N             KGV       S   ELLA
Sbjct: 350  RFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLA 409

Query: 1360 TFCDNILKKGG-SEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSAN 1536
             +CD +L+K   S+KL+ E IE  L++V+ +L Y+ +KD+F  +++  L RRL+ D SA+
Sbjct: 410  NYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISAD 469

Query: 1537 DEHERSILTKLKQ-QCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNPGIDLAVT 1713
             E E +++  L++      + +K+  M  D+ V+ D    F+E    +    P   + + 
Sbjct: 470  SEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIK 529

Query: 1714 VLTTGFWP-TYKSFDINLPAEMVRCVEVFKEFYQ 1812
            +L  G W  + +   ++LP E+   +   +EFY+
Sbjct: 530  ILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYK 563



 Score = 73.2 bits (178), Expect = 6e-12
 Identities = 66/227 (29%), Positives = 102/227 (44%), Gaps = 19/227 (8%)
 Frame = +2

Query: 1781 DVSRFSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGA--DK 1954
            +V  F K   K    +KL W + +    IT K E    +L VTT+Q A+L  +N    +K
Sbjct: 557  EVEEFYK---KNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREK 613

Query: 1955 LSYSEIVTQLNLSDDDVVRLLHSLSC---AKYKILTKEP---SNRSISPNDVFEFNSKFT 2116
            +S+  +     L D ++ R L SL      K ++L  EP   S +  +   +F  N +F+
Sbjct: 614  ISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFS 673

Query: 2117 -------DKMRRI----KIPLPPXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQT 2263
                    K  +I    ++ L                R      +I++IMK RK + +  
Sbjct: 674  LIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQ 733

Query: 2264 LVMECVEQLGRMFKPDFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
            L  E VE L  MF P  K IK++IE LI   Y+ RD+ + N + Y+A
Sbjct: 734  LQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780

---

>Q5RB36:CUL5_PONPY Cullin-5 - Pongo pygmaeus (Orangutan)|
          Length = 780

 Score =  168 bits (425), Expect = 1e-40
 Identities = 129/574 (22%), Positives = 262/574 (45%), Gaps = 35/574 (6%)
 Frame = +1

Query: 196  TVDLEEGWAFMQKGITKLKNILEGKPEPQFSSEDYMMLYTTIYNMCT--QKPPHDYSQQL 369
            ++  E+ W FM+  + KL        +   + + +  L++ ++ +C    K P    Q L
Sbjct: 12   SLQFEDKWDFMRPIVLKLLR------QESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQAL 65

Query: 370  YDKYRESFEEYISSMVLPSLREKHDEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISR 549
                +E   E+I       L  + D  +L+  +  W         L + F  L+   + +
Sbjct: 66   ----KEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGK 121

Query: 550  RSL--------PALREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQIDRALLKNVL 705
            +            +R++ L  + + ++  IK +++ + + L+  ER GE  D  L+  V 
Sbjct: 122  QGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVR 181

Query: 706  DIFVEIGLG---SMECYENDFEDFLLKDTADYYSIKAQTWIVEDSCPDYMLKAEECLKRE 876
            + +V +       ++ Y ++FE   L  T  +Y  +A +++ ++   +YM  A+  LK E
Sbjct: 182  ESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEE 241

Query: 877  KERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFS 1056
            ++R   YL +  E   +E +    +    +   E   + C  +++ ++ E L  M+ L  
Sbjct: 242  EKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMD 301

Query: 1057 RITRGLEPVSQIFKQHVTNEGTA-LVKQAEDAASNKKPEKKDIVGLQEQVFVRKIIELHD 1233
            ++  G+EP+ +  ++H+ + G A +V  AE   ++             + +V +++ L +
Sbjct: 302  KVPNGIEPMLKDLEEHIISAGLADMVAAAETITTD------------SEKYVEQLLTLFN 349

Query: 1234 KYVAYVTDCFQGHTLFHKALKEAFEVFCN-------------KGVS-----GSSSAELLA 1359
            ++   V + FQ    F  A  +A++   N             KGV       S   ELLA
Sbjct: 350  RFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLA 409

Query: 1360 TFCDNILKKGG-SEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSAN 1536
             +CD +L+K   S+KL+ E IE  L++V+ +L Y+ +KD+F  +++  L RRL+ D SA+
Sbjct: 410  IYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISAD 469

Query: 1537 DEHERSILTKLKQ-QCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNPGIDLAVT 1713
             E E +++  L++      + +K+  M  D+ V+ D    F+E    +    P   + + 
Sbjct: 470  SEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIK 529

Query: 1714 VLTTGFWP-TYKSFDINLPAEMVRCVEVFKEFYQ 1812
            +L  G W  + +   ++LP E+   +   +EFY+
Sbjct: 530  ILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYK 563



 Score = 73.2 bits (178), Expect = 6e-12
 Identities = 66/227 (29%), Positives = 102/227 (44%), Gaps = 19/227 (8%)
 Frame = +2

Query: 1781 DVSRFSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGA--DK 1954
            +V  F K   K    +KL W + +    IT K E    +L VTT+Q A+L  +N    +K
Sbjct: 557  EVEEFYK---KNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREK 613

Query: 1955 LSYSEIVTQLNLSDDDVVRLLHSLSC---AKYKILTKEP---SNRSISPNDVFEFNSKFT 2116
            +S+  +     L D ++ R L SL      K ++L  EP   S +  +   +F  N +F+
Sbjct: 614  ISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFS 673

Query: 2117 -------DKMRRI----KIPLPPXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQT 2263
                    K  +I    ++ L                R      +I++IMK RK + +  
Sbjct: 674  LIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQ 733

Query: 2264 LVMECVEQLGRMFKPDFKAIKKRIEDLITRDYLERDKENPNVYRYLA 2404
            L  E VE L  MF P  K IK++IE LI   Y+ RD+ + N + Y+A
Sbjct: 734  LQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780

---

>Q23639:CUL5_CAEEL Cullin-5 - Caenorhabditis elegans|
          Length = 741

 Score =  147 bits (372), Expect = 2e-34
 Identities = 122/462 (26%), Positives = 223/462 (48%), Gaps = 31/462 (6%)
 Frame = +1

Query: 442  DEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRRSLP-----ALREVGLSCFRDLVY 606
            D  +L   +K W+        L   F  +D     RRS+P     ++R V L  + ++++
Sbjct: 74   DGSLLIGYIKEWNRFYQQANILPLPFKKIDESS-RRRSVPETPEESIRTVMLEKWNEIIF 132

Query: 607  QEIKGKVKSAVISLIDQEREGEQIDRALLKNVLDIFVEI----GLGSMECYENDFEDFLL 774
              I  ++    + L+ +ER+G  ID   +  + + FV +    G   +  Y   FE   +
Sbjct: 133  MNISEQLLVEALRLVKEERDGNIIDAQNVIGIRESFVALNDRAGEDPLLVYRQSFERQFI 192

Query: 775  KDTADYYSIKAQTWIVEDSCPDYMLKAEECLKREKERVAHYL--HSSSEPKLLEKVQHEL 948
            + T +YY       + E    +YM+ A++ L+ E++R   YL  +S +  K +EK    L
Sbjct: 193  EQTTEYYKKICGNLLNELGVLEYMVYADKKLEEEQQRAKRYLEMNSPTSGKHMEKAVIAL 252

Query: 949  LTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEG-TA 1125
            +  +   +L +    C  L+    VE L R+YRL  R   G++ V +    H+  EG   
Sbjct: 253  VESFEDTILAE----CSKLIASKDVERLQRLYRLIRRTRSGIDTVLKCIDTHIRTEGLND 308

Query: 1126 LVKQAEDAASNKKPEKKDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAF 1305
            +   AE+ +++  PE+          +V++++ + DK+ + V + F        A  +AF
Sbjct: 309  MRNNAENLSTD--PER----------YVQQLLLMFDKFSSLVREGFCDDARLLTARDKAF 356

Query: 1306 EVFCN------------KGVS---GSSSAELLATFCDNILKKGG-SEKLSDEAIEDTLEK 1437
                N            KG +    S  AELLA +CD +L+K   S+KL+ E I++ L +
Sbjct: 357  RAVVNDSSIFKTEMMNKKGRTLSVESKCAELLANYCDLLLRKTQLSKKLTSEEIDEKLNQ 416

Query: 1438 VVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSILTKLKQQCG--GQFTSKMEG 1611
            V+ +L Y+ +KD+F  F+R  L+RRL+ + SA+ E E  ++TKL+ +CG      +K+  
Sbjct: 417  VLLVLKYVENKDVFMRFHRAHLSRRLILEMSADQEKEEMMVTKLR-ECGMPSDAVNKLSR 475

Query: 1612 MVTDLTVARDHQTKFEEFIS-THPELNPGIDLAVTVLTTGFW 1734
            M+ D+ + +D  + F++ ++ T+   +    + + VL  G W
Sbjct: 476  MLQDIELNKDMNSSFKKALTGTNNNKSIADSINMKVLNGGAW 517

---

>O14122:CUL4_SCHPO Cullin-4 - Schizosaccharomyces pombe (Fission yeast)|
          Length = 734

 Score =  147 bits (371), Expect = 2e-34
 Identities = 114/460 (24%), Positives = 211/460 (45%), Gaps = 12/460 (2%)
 Frame = +1

Query: 475  WSNHKVMVRWLSRFFHYLDRYFISRR-SLPALREVGLSCFRD--LVYQEIKGKVKSAVIS 645
            W+     V  +   F+Y+D+ F+S     P + E+ LS FR+  +  + I+    ++++ 
Sbjct: 111  WNKWLERVEIVQNIFYYMDKTFLSHHPDYPTIEELSLSLFREKLMAVKNIQIPFLNSLLQ 170

Query: 646  LIDQEREGEQIDRALLKNVLDIFVEIGLGSMECYENDFEDFLLKDTADYYSIKAQTWIVE 825
              +     +  D A L++ +     + L   E Y + F    L   + +Y  ++   I E
Sbjct: 171  SFENLHSSKSTDHAYLQDAM-----LMLHRTEMYSSVFVPMYLVMLSRFYDTESSQKIQE 225

Query: 826  DSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHAL 1005
                +Y+  A   L+RE   V  +     +  + E VQ  L+T +   L +    G    
Sbjct: 226  LPLEEYLEYAMSSLEREDAYVEKFDIVRDKKSIRETVQRCLITSHLDTLTK----GISQF 281

Query: 1006 LRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKKPEKKDIV 1185
            +          +Y L  +     E + Q +   + + G  LV            E KD  
Sbjct: 282  IEKRDAHSCKLLYALL-QFNHETEYLIQPWSDCLVDVGFKLVND----------ESKDDT 330

Query: 1186 GLQEQVFVRKIIE-------LHDKYVAYVTDCFQGHTLFHKALKEAFEVFCN--KGVSGS 1338
             +QE +   K ++       LHD+ ++Y             A+++AFE F N  KG    
Sbjct: 331  LVQELLSFHKFLQVVVDESFLHDETLSY-------------AMRKAFETFINGAKGSQRE 377

Query: 1339 SSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLL 1518
            + A L+A + D +L+ G  +    + +++   +++ L  YI+ KD+F  +Y+  +A+RLL
Sbjct: 378  APARLIAKYIDYLLRVG-EQASGGKPLKEVFSEILDLFRYIASKDIFEAYYKLDIAKRLL 436

Query: 1519 FDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELNPGI 1698
             +KSA+ ++E  +L  LK+ CG QFT  +EGM  D+ ++++  + F    + H   N   
Sbjct: 437  LNKSASAQNELMLLDMLKKTCGSQFTHSLEGMFRDVNISKEFTSSFRHSKAAH---NLHR 493

Query: 1699 DLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFKEFYQTR 1818
            DL V VL+  +WP+Y    I LP +M + ++ F++FY ++
Sbjct: 494  DLYVNVLSQAYWPSYPESHIRLPDDMQQDLDCFEKFYLSK 533



 Score =  122 bits (305), Expect = 1e-26
 Identities = 71/214 (33%), Positives = 115/214 (53%), Gaps = 7/214 (3%)
 Frame = +2

Query: 1781 DVSRFSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFN---GAD 1951
            D+  F K ++ +++ KK++W  SLG C + A+F     EL ++ +QA +LL FN   G +
Sbjct: 522  DLDCFEKFYLSKQVGKKISWYASLGHCIVKARFPLGNKELSISLFQACVLLQFNNCLGGE 581

Query: 1952 KLSYSEIVTQLNLSDDDVVRLLHSLSCAKYKILTKEPSNRSISPNDVFEFNSKFTDKMRR 2131
             +SY ++     LSD D+ R L SLSCA+ + L   P ++  SP+ +F  N KFTDK+ R
Sbjct: 582  GISYQDLKKSTELSDIDLTRTLQSLSCARIRPLVMVPKSKKPSPDTMFYVNEKFTDKLYR 641

Query: 2132 IKIP----LPPXXXXXXXXXXXXXXRRYAIDASIVRIMKSRKVLGHQTLVMECVEQLGRM 2299
            +KI                      R++ + ASIVR+MK ++ + H  LV   +  +   
Sbjct: 642  VKINQIYLKEERQENSDVQEQVVRDRQFELQASIVRVMKQKEKMKHDDLVQYVINNVKDR 701

Query: 2300 FKPDFKAIKKRIEDLITRDYLERDKENPNVYRYL 2401
              P    +K  IE L+ ++YLER  E+ ++Y Y+
Sbjct: 702  GIPLVSDVKTAIEKLLEKEYLER--EDNDIYTYV 733

---

>P53202:CUL3_YEAST Cullin-3 - Saccharomyces cerevisiae (Baker's yeast)|
          Length = 744

 Score = 87.4 bits (215), Expect(2) = 8e-32
 Identities = 109/529 (20%), Positives = 228/529 (43%), Gaps = 18/529 (3%)
 Frame = +1

Query: 298  YMMLYTTIYNMCTQKPPHDYSQQLYDKYRESFEEYISSMVLPSLREK-HDEFMLRELVKR 474
            +  +Y TIY +   K        LY++ ++   + ++ +    +++  HD   L  + + 
Sbjct: 46   FEQVYKTIYTIVLNKK----GPILYNRLKDYLIQKLALLRETIVKDNTHDYEFLGTMARL 101

Query: 475  WSNHKVMVRWLSRFFHYLDRYFISRRSLPALREVGLSCFRDLVYQEIKGKVKSAVISLID 654
            W       +       Y+D+ +        + ++ L  FR  + Q+    + SA+IS I+
Sbjct: 102  WEVQCHCFKITGDLMMYMDKVYCKPNRCMEVYDMCLDLFRIEILQKCSSSLISALISDIE 161

Query: 655  QEREGEQIDR---ALLKNVLDIFVEIGLGSMECYENDFEDFLLKDTADYYSIKAQTWIVE 825
            + R    +D    +L K ++ +   +       +  DFE  L+  T +YY+      ++ 
Sbjct: 162  RIRNLGSVDSEHTSLWKVLIGMMETLHDNRDSFFLTDFEPVLISATEEYYNKAIDIELLT 221

Query: 826  DSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHAL 1005
                + + K  +  + E    + +L+  S  KL   +++ L+    S ++E      H  
Sbjct: 222  PI--ESLEKIRKLRQFESMLDSSFLNVDSHNKLKTVLENVLIWGKLSDIIEDL---THEA 276

Query: 1006 LRDDKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKKPEKKDIV 1185
            +     + L  +Y L S     +  +  I K ++        K A +   N+   KK   
Sbjct: 277  MVISNGKLLQEIYDLSSEEKYRVTVIESI-KSYIN-------KNAINIPFNEGNRKK--- 325

Query: 1186 GLQEQVFVRKIIELHDKYVAYVTDCFQGHTLFHKA--------LKEAFEVFCNKGVSGSS 1341
            G     +  +I+EL+    +++     G    +          L + F ++ +K   G+ 
Sbjct: 326  GQNAITWSSEIVELYRSQHSFLESIDFGSVRLNNLTGDVSNAILGDVFSMYFSK--EGAL 383

Query: 1342 SAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLF 1521
             +E L+T+ D+ +K+   +      I+  L    +L+  +++KD+F + Y+K+L+RRLL 
Sbjct: 384  PSEYLSTYVDHCMKRTKEKDAEIVKIKQDLLDSTKLIGLLTEKDIFEKIYKKQLSRRLLQ 443

Query: 1522 DKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTVARDHQTKFEEFISTHPELN--PG 1695
             +S   E E+ ++  +K+  G  FTSK+E M+ D++++ +    F+     H  +N    
Sbjct: 444  QRSL-VEIEKWMVQMIKKVLGTFFTSKLEIMLRDISLSSEMYQAFQ-----HSTINSIEY 497

Query: 1696 IDLAVTVLTTGFWPTYKS----FDINLPAEMVRCVEVFKEFYQTRTKQK 1830
            +  A  VLT   WP   +      I+LP  M + +  F+ +Y  + K++
Sbjct: 498  LSFAPQVLTRTSWPFQSTNPIDEGISLPPRMSQILAGFEGYYSLKYKER 546



 Score = 72.8 bits (177), Expect(2) = 8e-32
 Identities = 55/201 (27%), Positives = 92/201 (45%), Gaps = 10/201 (4%)
 Frame = +2

Query: 1832 LTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEIVTQLNLSDDDVVR 2011
            L W + L +  I  +F +   E+  + Y   + LLF   ++L+  EI    ++  DDV  
Sbjct: 548  LKWAHHLSVIEIGCQFNSGYYEISFSVYAGVIFLLFEDYEELTLGEIYELTHIPIDDVKS 607

Query: 2012 LLHSLSCA-KYKILTKEPSNRSISPNDVFEFNSKFTDKMRRIKIPL---PPXXXXXXXXX 2179
            L+ S+S   + KIL K  S    S N  F  N  F+   R++K+P+   P          
Sbjct: 608  LVMSMSTIPRCKILKKSSS----SGNMKFSVNYFFSSPNRKVKVPVIACPLPSQKSDNLA 663

Query: 2180 XXXXXRRY------AIDASIVRIMKSRKVLGHQTLVMECVEQLGRMFKPDFKAIKKRIED 2341
                   Y       + A IVRIMK+   L HQ L+    ++           +K+ I+ 
Sbjct: 664  TASSVDTYDNEIVMELSAIIVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSILKRSIQL 723

Query: 2342 LITRDYLERDKENPNVYRYLA 2404
            LI ++Y++R+ ++P+ Y YL+
Sbjct: 724  LIEKEYIQRNADDPSYYHYLS 744

---

>Q8BZQ7:ANC2_MOUSE Anaphase-promoting complex subunit 2 - Mus musculus (Mouse)|
          Length = 837

 Score = 49.7 bits (117), Expect = 7e-05
 Identities = 35/130 (26%), Positives = 58/130 (44%), Gaps = 1/130 (0%)
 Frame = +1

Query: 1447 LLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDL 1626
            L++    KDLF   YR  LA RLL   S + E E   +  LK + G       E M+ D+
Sbjct: 520  LVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDM 579

Query: 1627 TVARDHQTKFEEFISTHP-ELNPGIDLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFKE 1803
              +R       E     P E  P   +   +L++ FWP +K   + +P ++   ++V+ +
Sbjct: 580  ADSRRINANIREEDEKRPVEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALDVYCK 639

Query: 1804 FYQTRTKQKT 1833
             Y+     +T
Sbjct: 640  KYEKLKAMRT 649



 Score = 32.7 bits (73), Expect = 8.6
 Identities = 15/60 (25%), Positives = 31/60 (51%)
 Frame = +2

Query: 1793 FSKSFIKQELSKKLTWIYSLGICHITAKFEAKTIELIVTTYQAALLLLFNGADKLSYSEI 1972
            + K + K +  + L+W ++LG+  +  +   +T+ + VT  QA +LL F      +  E+
Sbjct: 637  YCKKYEKLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQALVLLYFQNQASWTLEEL 696

---

>Q9UJX6:ANC2_HUMAN Anaphase-promoting complex subunit 2 - Homo sapiens (Human)|
          Length = 822

 Score = 49.3 bits (116), Expect = 9e-05
 Identities = 35/130 (26%), Positives = 57/130 (43%), Gaps = 1/130 (0%)
 Frame = +1

Query: 1447 LLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDL 1626
            L++    KDLF   YR  LA RLL   S + E E   +  LK + G       E M+ D+
Sbjct: 505  LVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDM 564

Query: 1627 TVARDHQTKFEEFISTHP-ELNPGIDLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFKE 1803
              +R       E     P E  P   +   +L++ FWP +K   + +P ++   +E + +
Sbjct: 565  ADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCK 624

Query: 1804 FYQTRTKQKT 1833
             Y+     +T
Sbjct: 625  KYEQLKAMRT 634

---

>P34514:ANC2_CAEEL Anaphase-promoting complex subunit 2 - Caenorhabditis elegans|
          Length = 728

 Score = 42.0 bits (97), Expect = 0.014
 Identities = 32/126 (25%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
 Frame = +1

Query: 1447 LLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDL 1626
            L++    K+LF + YR  LA RL    + + E E+  L  LK +         E M+ D+
Sbjct: 402  LVSVYGSKELFVKEYRNLLAERLSSSDNKDPEFEKRYLDLLKLRFQYSELQHCEVMLRDV 461

Query: 1627 TVARDHQTKFEEFISTHPELN---PGIDLAVTVLTTGFWPTYKS--FDINLPAEMVRCVE 1791
              + D   KFE+ +S     N   P I ++  ++++ +WP  ++   +  +P  +   ++
Sbjct: 462  IHSLDIDKKFED-MSERSAGNYDVPIIPISACIISSHYWPKLETEKTEALMPQPLQAAMD 520

Query: 1792 VFKEFY 1809
            V++E Y
Sbjct: 521  VYQETY 526

---

>Q874R3:APC2_SCHPO Anaphase-promoting complex subunit 2 - Schizosaccharomyces pombe|
            (Fission yeast)
          Length = 681

 Score = 38.5 bits (88), Expect = 0.16
 Identities = 35/140 (25%), Positives = 61/140 (43%), Gaps = 2/140 (1%)
 Frame = +1

Query: 1447 LLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDL 1626
            L++    K+   +  +  LA RLL     + E E   +  LK + G         M+ D+
Sbjct: 379  LISIFKSKEPLVKELQLLLADRLLQLTDYHYEVEAKNIEFLKYRFGETVLQMCSVMLNDI 438

Query: 1627 TVAR--DHQTKFEEFISTHPELNPGIDLAVTVLTTGFWPTYKSFDINLPAEMVRCVEVFK 1800
              +R  D     E ++S          L VT+L+  FWPT      +LP  + + ++ + 
Sbjct: 439  ENSRFIDQSIHMENYVSK--------GLHVTILSRLFWPTLSVRYFHLPGPLKKELDAYA 490

Query: 1801 EFYQTRTKQKTYMDIFLGNL 1860
            E Y+ R +++    +FL NL
Sbjct: 491  EEYRERKRKREL--VFLPNL 508

---

>Q68WR2:SYW_RICTY Tryptophanyl-tRNA synthetase - Rickettsia typhi|
          Length = 330

 Score = 35.8 bits (81), Expect = 1.0
 Identities = 32/129 (24%), Positives = 58/129 (44%), Gaps = 4/129 (3%)
 Frame = +1

Query: 541 ISRRSLPALREVGLSCFRDLVYQEIKGKVKSAVISLIDQEREGEQIDRALLKNVLDIFVE 720
           +S+  +     + L    DL+YQ+IK K K+  +S I  +++     R  + N+LDI+  
Sbjct: 196 MSKSDIADFSRINLKDSNDLIYQKIK-KAKTDHLSFISYDKK----TRPEISNLLDIYKS 250

Query: 721 IGLGSMECYENDFED----FLLKDTADYYSIKAQTWIVEDSCPDYMLKAEECLKREKERV 888
           +   SME   N++++       +D A+      Q   + D C + M         +KE +
Sbjct: 251 LSKESMEKIINNYQNQGFAKFKEDLAEIIITNLQP--IRDKCLELM--------NDKEYL 300

Query: 889 AHYLHSSSE 915
              LH  +E
Sbjct: 301 LKILHKGAE 309

---

>Q9GL21:UACA_CANFA Uveal autoantigen with coiled-coil domains and ankyrin repeats -|
            Canis familiaris (Dog)
          Length = 1415

 Score = 35.0 bits (79), Expect = 1.7
 Identities = 53/209 (25%), Positives = 97/209 (46%), Gaps = 26/209 (12%)
 Frame = +1

Query: 616  KGKVKSAVISLIDQEREGEQIDRAL--LKNVLDIFVEIGLGSMECYENDFEDFLLKDTAD 789
            K K+KS +++   +E++ E+  R +  LKN    F    LGS   + N  ED LLK    
Sbjct: 347  KEKLKSLLVA---KEKQHEESLRTIESLKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQM 403

Query: 790  YYSI-----------KAQTWIVEDSCPDYMLKAE-ECLKREKERVAHYLHSSSEPKLLEK 933
            Y +            ++    +E S P+    +E + LK+E E +  +  S+ + +L  K
Sbjct: 404  YMTCTSPGVPAHMQSRSMLRPLELSLPNQTSYSENDLLKKELEAMRTFCESAKQDRL--K 461

Query: 934  VQHELLTQYA---SQLLE----KEHSGCHALLRDDKVEDL-SRMYRLFSRITRGLEPVSQ 1089
            +Q+EL  + A   +  LE    KE S       +D ++D+  RMY    ++ + ++    
Sbjct: 462  LQNELAHKVAECKALGLECERIKEDSDEQIKQLEDALKDVQKRMYESEGKV-KQMQTHFL 520

Query: 1090 IFKQHVTNEGT----ALVKQAEDAASNKK 1164
              K+H+T+E       L+++ +D   + K
Sbjct: 521  ALKEHLTSEAAIGNHRLMEELKDQLKDMK 549

---

>Q3TES0:IQEC3_MOUSE IQ motif and Sec7 domain-containing protein 3 - Mus musculus (Mouse)|
          Length = 1195

 Score = 34.7 bits (78), Expect = 2.2
 Identities = 38/130 (29%), Positives = 51/130 (39%), Gaps = 3/130 (2%)
 Frame = -3

Query: 2498 AMAQNIASLNSSSLVGIHTRCYRTQHAEPMIKPSIGRRSGSPCPSPGN---PWL*DPQCA 2328
            AMA   A+  SS  V IH R   +QH+     P +G   G+P PSP     P   DPQ +
Sbjct: 1030 AMAGEKAA-ESSGEVSIHNRLQTSQHS-----PKLGVERGAPAPSPPTSPPPLPPDPQPS 1083

Query: 2327 SLLL*SQA*TCDQAAPHTPLLVSGDPRLCGSS*YEQLMHQLRIFDPCQHLQQPSFSHQLE 2148
             L          +  P  PL     P        +Q++  + +  PC    +P  S  L 
Sbjct: 1084 PL---------REQPPPLPLPPPTPPGTLVQC--QQIVKVIVLDKPCLARMEPLLSQALS 1132

Query: 2147 AEVS*FSSSC 2118
               S  S SC
Sbjct: 1133 CYASSSSDSC 1142

---

>Q9HIH6:Y1363_THEAC Putative HTH-type transcriptional regulatory protein Ta1363 -|
           Thermoplasma acidophilum
          Length = 312

 Score = 34.3 bits (77), Expect = 2.9
 Identities = 30/94 (31%), Positives = 49/94 (52%), Gaps = 8/94 (8%)
 Frame = +1

Query: 523 YLDRYF-ISRRSLPALREVGLSCFRDLVYQEIKGKVKSAVIS-------LIDQEREGEQI 678
           YL  Y  +SRRS+ +L E G S   D V+ +++  +KS ++        + D  +E E++
Sbjct: 146 YLSHYLGVSRRSV-SLYENGSSATID-VFLKLQEIIKSDLVDHTDLFKIIPDNFQEEERV 203

Query: 679 DRALLKNVLDIFVEIGLGSMECYENDFEDFLLKD 780
           D   ++ +LDI   IGL +   Y   F D L +D
Sbjct: 204 DDVYIQMLLDILERIGLDTKPAYRMPF-DILARD 236

---

>P62134:RAD50_METMP DNA double-strand break repair rad50 ATPase - Methanococcus|
            maripaludis
          Length = 993

 Score = 34.3 bits (77), Expect = 2.9
 Identities = 61/251 (24%), Positives = 101/251 (40%), Gaps = 28/251 (11%)
 Frame = +1

Query: 607  QEIKGKVKSAVISLIDQEREGEQIDRALLKNVL-DIFVEIGLGSMECYENDFEDFLLKDT 783
            + +K ++K+ + +L     E E   +  LKN+  DI  +IG+  +ECY            
Sbjct: 658  ENLKDELKNTIYNL-----EREINLKKELKNIQNDISSKIGI--VECYVK---------- 700

Query: 784  ADYYSIKAQTWIVEDSCPDYMLKAEECLKREKERVAHYLHSSSEPKLLEK---VQHELLT 954
                      W  E S  D+  K  EC    KE    Y+ S +  K   K   V+   L 
Sbjct: 701  ----------WETEKS--DFENKLSEC----KENYEKYMESLAVLKNYSKTYSVEINNLN 744

Query: 955  QYASQLLEKEHSGCHALLRD---------------DKVEDLSRMYRL----FSRITRGLE 1077
            ++ +Q + ++   C  LL                 +  E+  R+Y      F+ I R LE
Sbjct: 745  EFLNQKIAEKQQFCEKLLETRTEIEKNIQTVNYNPELHENAKRLYENILNEFNDILRTLE 804

Query: 1078 PVSQIFKQHVTNEGTALVKQAEDAASNKKPEKKDIVGLQEQV-FVRKIIELHDKYVAYVT 1254
             +S   K  + NE  + + +     SNKK EKK I   +E +  +++ I   D +  Y+ 
Sbjct: 805  RISSELK--LKNENISYLNEKIQNLSNKKEEKKKIEEFKEYLDKIKREIFSKDGFQKYLR 862

Query: 1255 DCF----QGHT 1275
            + +    Q HT
Sbjct: 863  EKYIPLIQRHT 873

---

>P31630:VGNM_CPSMV Genome polyprotein M - Cowpea severe mosaic virus (strain DG) (CPSMV)|
          Length = 1002

 Score = 33.9 bits (76), Expect = 3.8
 Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 2/81 (2%)
 Frame = +1

Query: 1204 FVRKIIELHDKYVAYVTDCFQGHTLFHKALKEAFEVFCNKG--VSGSSSAELLATFCDNI 1377
            F +K+ ELH+ Y +   D F     F+K   E F+++   G  V  S    LL  F   I
Sbjct: 30   FEKKLAELHEWYWSLALDPFPYSGFFYKCFYELFQLWVKLGLIVQVSYLILLLDFFVYTI 89

Query: 1378 LKKGGSEKLSDEAIEDTLEKV 1440
             KK  S+      IE T+EKV
Sbjct: 90   PKKMASQ------IETTVEKV 104

---

>P12270:TPR_HUMAN Nucleoprotein TPR - Homo sapiens (Human)|
          Length = 2349

 Score = 33.9 bits (76), Expect = 3.8
 Identities = 35/128 (27%), Positives = 59/128 (46%)
 Frame = +1

Query: 856  EECLKREKERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVEDLS 1035
            EE L +EK+ V   +  + E +L E  + +  TQ   +L+E E       L+DDK   + 
Sbjct: 973  EESLNKEKQ-VTEEVRKNIEVRLKESAEFQ--TQLEKKLMEVEKEKQE--LQDDKRRAIE 1027

Query: 1036 RMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKKPEKKDIVGLQEQVFVRK 1215
             M +  S + + L  V         NE    +++A  A SN++  ++D    QEQ  +  
Sbjct: 1028 SMEQQLSELKKTLSSVQ--------NEVQEALQRASTALSNEQQARRD---CQEQAKI-- 1074

Query: 1216 IIELHDKY 1239
             +E  +KY
Sbjct: 1075 AVEAQNKY 1082

---

>Q53EZ4:CEP55_HUMAN Centrosomal protein of 55 kDa - Homo sapiens (Human)|
          Length = 464

 Score = 33.9 bits (76), Expect = 3.8
 Identities = 33/134 (24%), Positives = 55/134 (41%), Gaps = 5/134 (3%)
 Frame = +1

Query: 850  KAEECLKREKERVAHYLHS-----SSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRD 1014
            K+E  L++ K  +AH   S     S + KL +K +H LL +      EKE +      +D
Sbjct: 22   KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKD 81

Query: 1015 DKVEDLSRMYRLFSRITRGLEPVSQIFKQHVTNEGTALVKQAEDAASNKKPEKKDIVGLQ 1194
             +++ L    +     T  LE +     +  T EG     +  +       E+KD++  Q
Sbjct: 82   KEIQRLRDQLKARYSTTALLEQL-----EETTREG-----ERREQVLKALSEEKDVLKQQ 131

Query: 1195 EQVFVRKIIELHDK 1236
                  +I EL  K
Sbjct: 132  LSAATSRIAELESK 145

---

>Q9BZF9:UACA_HUMAN Uveal autoantigen with coiled-coil domains and ankyrin repeats - Homo|
            sapiens (Human)
          Length = 1416

 Score = 33.5 bits (75), Expect = 5.0
 Identities = 50/191 (26%), Positives = 87/191 (45%), Gaps = 23/191 (12%)
 Frame = +1

Query: 622  KVKSAVISLIDQEREGEQIDRALLKNVLDIFVEIGLGSMECYENDFEDFLLKDTADYYS- 798
            K+KS + +   Q  E  +   AL KN    F    LGS   + N  ED LLK    Y + 
Sbjct: 347  KLKSLLAAKEKQHEESLRTIEAL-KNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMAD 405

Query: 799  -----------IKAQTWI--VEDSCPDYMLKAE-ECLKREKERVAHYLHSSSEPKLLEKV 936
                       +++++ +  +E S P     +E E LK+E E +  +  S+ + +L  K+
Sbjct: 406  SQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRL--KL 463

Query: 937  QHELLTQYA---SQLLE----KEHSGCHALLRDDKVEDL-SRMYRLFSRITRGLEPVSQI 1092
            Q+EL  + A   +  LE    KE S       +D ++D+  RMY    ++ + ++     
Sbjct: 464  QNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKV-KQMQTHFLA 522

Query: 1093 FKQHVTNEGTA 1125
             K+H+T+E  +
Sbjct: 523  LKEHLTSEAAS 533

---

>Q99N96:RM01_MOUSE 39S ribosomal protein L1, mitochondrial precursor - Mus musculus|
            (Mouse)
          Length = 314

 Score = 33.5 bits (75), Expect = 5.0
 Identities = 31/98 (31%), Positives = 47/98 (47%)
 Frame = +1

Query: 1339 SSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLL 1518
            ++A   AT     +KKG  EK SDE   D +EK+       SD +   + Y K+L  R +
Sbjct: 22   AAAAAAATKPARKIKKGAKEKTSDEKPVDDIEKIKSYTYMESDPE--DDVYLKRLYPRRI 79

Query: 1519 FDKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDLTV 1632
            +      E E++I    K Q    FT+  +G+  DLT+
Sbjct: 80   Y------EVEKAIHLLKKFQV-LDFTNPKQGVYLDLTL 110

---

>P50491:AMA1_PLAFH Apical membrane antigen 1 precursor - Plasmodium falciparum|
           (isolate thtn / Thailand)
          Length = 622

 Score = 33.5 bits (75), Expect = 5.0
 Identities = 34/148 (22%), Positives = 59/148 (39%), Gaps = 16/148 (10%)
 Frame = +1

Query: 280 QFSSEDYMMLYTTIYNMCTQKPPHDYSQQL--YDKYRESFEEYISSMV----LPSLREKH 441
           +FS+ D       ++ +     P  Y Q L  Y+K +E F+   +SM+    LP+   K 
Sbjct: 328 EFSANDLFECNKLVFELSASDQPKQYEQHLTDYEKIKEGFKNKNASMIKSAFLPTGAFKA 387

Query: 442 DEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRRSLPALREVG----------LSCF 591
           D +  R     W N+    +     F+      I+  S  A   +            S +
Sbjct: 388 DRYKSRGKGYNWGNYNTETQ-KCEIFNVKPTCLINNSSYIATTALSHPNEVENNFPCSLY 446

Query: 592 RDLVYQEIKGKVKSAVISLIDQEREGEQ 675
           +D + +EI+ + K   I L D + EG +
Sbjct: 447 KDEIKKEIERESKR--IKLNDNDDEGNK 472

---

>P50492:AMA1_PLAF8 Apical membrane antigen 1 precursor - Plasmodium falciparum|
           (isolate 7G8)
          Length = 622

 Score = 33.5 bits (75), Expect = 5.0
 Identities = 39/173 (22%), Positives = 69/173 (39%), Gaps = 18/173 (10%)
 Frame = +1

Query: 280 QFSSEDYMMLYTTIYNMCTQKPPHDYSQQL--YDKYRESFEEYISSMV----LPSLREKH 441
           +FS+ D       ++ +     P  Y Q L  Y+K +E F+   +SM+    LP+   K 
Sbjct: 328 EFSANDLFECNKLVFELSASDQPKQYEQHLTDYEKIKEGFKNKNASMIKSAFLPTGAFKA 387

Query: 442 DEFMLRELVKRWSNHKVMVRWLSRFFHYLDRYFISRRSLPALREVG----------LSCF 591
           D +  R     W N+    +     F+      I+  S  A   +            S +
Sbjct: 388 DRYKSRGKGYNWGNYNRKTQ-KCEIFNVKPTCLINNSSYIATTALSHPNEVEHNFPCSLY 446

Query: 592 RDLVYQEIKGKVKSAVISLIDQEREGEQIDRALLKNVL--DIFVEIGLGSMEC 744
           +D + +EI+ + K   I L D + EG        K ++   IF+   + S++C
Sbjct: 447 KDEIKKEIERESKR--IKLNDNDDEGN-------KKIIAPRIFISDDIDSLKC 490

---

>Q76M68:IQEC3_RAT IQ motif and Sec7 domain-containing protein 3 - Rattus norvegicus|
            (Rat)
          Length = 1194

 Score = 33.1 bits (74), Expect = 6.5
 Identities = 38/131 (29%), Positives = 50/131 (38%), Gaps = 4/131 (3%)
 Frame = -3

Query: 2498 AMAQNIASLNSSSLVGIHTRCYRTQHAEPMIKPSIGRRSGSPCPSPGN----PWL*DPQC 2331
            AMA   A+  SS  V IH R    QH+     P +G   G+P PSP      P   DPQ 
Sbjct: 1028 AMAGEKAT-ESSGEVSIHNRLQTFQHS-----PKLGVERGAPAPSPPTSPPPPLPPDPQP 1081

Query: 2330 ASLLL*SQA*TCDQAAPHTPLLVSGDPRLCGSS*YEQLMHQLRIFDPCQHLQQPSFSHQL 2151
            + L          +  P  PL     P        +Q++  + +  PC    +P  S  L
Sbjct: 1082 SPL---------REQPPPLPLPPPTPPGTLVQC--QQIVKVIVLDKPCLARMEPLLSQAL 1130

Query: 2150 EAEVS*FSSSC 2118
                S  S SC
Sbjct: 1131 SCYASSSSDSC 1141

---

>Q9X1B6:SYA_THEMA Alanyl-tRNA synthetase - Thermotoga maritima|
          Length = 863

 Score = 33.1 bits (74), Expect = 6.6
 Identities = 34/155 (21%), Positives = 66/155 (42%), Gaps = 4/155 (2%)
 Frame = +1

Query: 1174 KDIVGLQEQVFVRKIIELHDKYVAYVTDCFQGHT----LFHKALKEAFEVFCNKGVSGSS 1341
            K+I+G +E     +++ L +K         QG      +  K L++  +VF   GV    
Sbjct: 715  KEILGAREDELTDRVLSLREKVKELEKKLSQGRISEERIAMKQLEDGVKVF--HGVFEGV 772

Query: 1342 SAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLF 1521
             A+ L    DN+LKK G   +    +    E  V L+  +S+ +L  ++    +AR +  
Sbjct: 773  EAKHLGGIADNVLKKEGEGIV---ILFSKFENKVSLVVKVSE-NLLGKYDASSIARNIAK 828

Query: 1522 DKSANDEHERSILTKLKQQCGGQFTSKMEGMVTDL 1626
            +   N    ++       Q GG+   +++ ++  L
Sbjct: 829  ELGGNGGGRKNF-----AQAGGRHPERIKDVLERL 858

---

>P47849:RF1_COXBU Peptide chain release factor 1 - Coxiella burnetii|
          Length = 361

 Score = 33.1 bits (74), Expect = 6.6
 Identities = 28/108 (25%), Positives = 46/108 (42%)
 Frame = +1

Query: 913  EPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFSRITRGLEPVSQI 1092
            +P L+EK++           L   +S    LL D  V +    YR   +    LEP+ + 
Sbjct: 2    KPSLIEKLK----------TLTYRYSEIGGLLSDSTVINDQDRYRELGKEYAQLEPIVKC 51

Query: 1093 FKQHVTNEGTALVKQAEDAASNKKPEKKDIVGLQEQVFVRKIIELHDK 1236
            F+Q   NE    ++ AE+    K PE + +   + +    K  EL D+
Sbjct: 52   FQQFQQNE--KAIESAEEMQQEKDPELRKLAEEELEQLTLKKEELEDQ 97

---

>Q8CGB3:UACA_MOUSE Uveal autoantigen with coiled-coil domains and ankyrin repeats - Mus|
            musculus (Mouse)
          Length = 1411

 Score = 32.7 bits (73), Expect = 8.6
 Identities = 53/269 (19%), Positives = 109/269 (40%), Gaps = 10/269 (3%)
 Frame = +1

Query: 910  SEPKLLEKVQH----ELLTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFSRITRGLE 1077
            ++ KLL +  H    E+ T+Y    + +E    H    D  VEDL++  +L     R  E
Sbjct: 726  ADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKRSH----DVNVEDLNK--KLSEATQRYAE 779

Query: 1078 PVSQIFKQHVTNEG-TALVKQAEDAASNKKPEKKDIVGLQEQV--FVRKIIELHDKYVAY 1248
               +  +    N+  T  V + E      +  +K+++GL+  +    +++ EL+ K    
Sbjct: 780  KKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKK---- 835

Query: 1249 VTDCFQGHTLFHKALKEAFEV---FCNKGVSGSSSAELLATFCDNILKKGGSEKLSDEAI 1419
               C +G       + E   +     ++ V   +  E+ A+    + K   +   + +  
Sbjct: 836  ---CGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRF 892

Query: 1420 EDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSILTKLKQQCGGQFTS 1599
            +DT ++V +L     D++       + +  ++  D  + +EH R + T  +        S
Sbjct: 893  DDTSQEVSKL----RDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQ--------S 940

Query: 1600 KMEGMVTDLTVARDHQTKFEEFISTHPEL 1686
              E    +  +  DH+   EE +S H E+
Sbjct: 941  LKEAQEANAAILADHRQGQEEIVSLHAEI 969

---

>Q13439:GOGA4_HUMAN Golgin subfamily A member 4 - Homo sapiens (Human)|
          Length = 2230

 Score = 32.7 bits (73), Expect = 8.6
 Identities = 65/288 (22%), Positives = 116/288 (40%), Gaps = 2/288 (0%)
 Frame = +1

Query: 700  VLDIFVEIGLGSMECYENDFEDFLLKDTADYYSIKAQTWIVEDSCPDYMLKAEECLKREK 879
            V ++ +++ L S E YE D +  LLK+  D  +                 K  +CLK E 
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQN-----------------KRFDCLKGEM 1502

Query: 880  ERVAHYLHSSSEPKLLEKVQHELLTQYASQLLEKEHSGCHALLRDDKVEDLSRMYRLFSR 1059
            E          +   +EK +  L T+  SQ         H   +  ++E L+ + + +++
Sbjct: 1503 E---------DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ 1553

Query: 1060 ITRGLEPVSQIFK-QHVTNEGTALVKQAEDAASNKKPEKKDIVGLQEQVFVRKI-IELHD 1233
              + +E    + K QH    G       E+  +  K  ++ I+ L+ QV+  K  +E   
Sbjct: 1554 -QKDIEHKELVQKLQHFQELG-------EEKDNRVKEAEEKILTLENQVYSMKAELETKK 1605

Query: 1234 KYVAYVTDCFQGHTLFHKALKEAFEVFCNKGVSGSSSAELLATFCDNILKKGGSEKLSDE 1413
            K + +V    +      KAL++  E         S SA  LA      LK+   +K++  
Sbjct: 1606 KELEHVNLSVKSKEEELKALEDRLE---------SESAAKLAE-----LKRKAEQKIA-- 1649

Query: 1414 AIEDTLEKVVRLLAYISDKDLFAEFYRKKLARRLLFDKSANDEHERSI 1557
            AI+       +LL+ + +K+   E Y+K     L    +   E ER +
Sbjct: 1650 AIKK------QLLSQMEEKE---EQYKKGTESHLSELNTKLQEREREV 1688


  Database: uniprot_sprot.fasta.out
    Posted date:  Jul 19, 2007  5:58 PM
  Number of letters in database: 100,686,439
  Number of sequences in database:  274,295
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 274295
Number of Hits to DB: 467,677,610
Number of extensions: 10315483
Number of successful extensions: 29045
Number of sequences better than 10.0: 50
Number of HSP's gapped: 28880
Number of HSP's successfully gapped: 79
Length of query: 941
Length of database: 100,686,439
Length adjustment: 123
Effective length of query: 818
Effective length of database: 66,948,154
Effective search space: 54763589972
Effective search space used: 54763589972
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

---