ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | FLbaf97k03 |
|---|---|
| Clone Library Name | barley_pub |
>Q09499:IRE1_CAEEL Serine/threonine-protein kinase/endoribonuclease ire-1 precursor -| Caenorhabditis elegans Length = 967 Score = 292 bits (747), Expect = 2e-78 Identities = 162/398 (40%), Positives = 238/398 (59%), Gaps = 9/398 (2%) Frame = +3 Query: 6 GSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVY 185 G GTVV+ G++DGREVAVKR++ A +E L SD P+++R + + D F Y Sbjct: 527 GCEGTVVYRGTFDGREVAVKRVVSEFVKFAHREADLLRESDTHPHVIRYFCMESDSQFRY 586 Query: 186 ISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSL 365 ++LE C SL D ++Q +V++ +V + +D +M+ G+ HLH+ Sbjct: 587 LALELCIASLNDYVEQ------KEVQQ-NVTIALRD---------IMKQATDGLAHLHAS 630 Query: 366 GIIHRDLKPQNVLI---SKEGSLSAKLSDMGISKRLQEDMSSLSHH-GTGY-GSSGWQAP 530 I+HRD+KPQNVLI S+ G + A +SD G+ KR+Q +S+S +G G+ GW AP Sbjct: 631 KIVHRDMKPQNVLITMASQRGEMRAVISDFGLCKRVQPGKNSISRGIASGLAGTDGWIAP 690 Query: 531 EQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPE--- 701 E L AS + +D+FSLGC+ +Y +T G HPFG+ R NI+NG + L + + + Sbjct: 691 EVLISASTSYPVDIFSLGCIFYYVLTSGTHPFGKSLHRQANIVNGEYTLNKLADLDDWSL 750 Query: 702 AVHLISLLLQPKPDERPTAMYAINHPLFWSPELRLLFLRDTSDRIEKTTETD-LLNALES 878 A LIS +L +P R TA +NHP FW+ E RL + D SDR+EK + ++ +E+ Sbjct: 751 ADDLISSMLNVEPLHRLTADAVLNHPFFWTSEKRLAYFSDVSDRVEKEEDNSPVVRRIET 810 Query: 879 IGHQAFGGKWREKLDDGLVADVGRYRKYNFESTRDLLRLIRNKSGHYRELPTDLKESLGS 1058 G WREK+ D L D+ ++R Y S RDLLR +RNK HYRELP D+++SLG Sbjct: 811 DARIVVCGGWREKICDALKEDLRKFRTYKSFSVRDLLRAMRNKKHHYRELPEDVRQSLGD 870 Query: 1059 LPEGFDRYFSSRFPKLLIEVYKVMSVYCKDEEDFRKYF 1172 +P+ F YF+SRFP+LL+ VYK + YC E F++Y+ Sbjct: 871 IPDQFLHYFTSRFPRLLLHVYKA-TEYCSGEAVFKRYY 907
>Q9EQY0:ERN1_MOUSE Serine/threonine-protein kinase/endoribonuclease IRE1 precursor - Mus| musculus (Mouse) Length = 977 Score = 277 bits (709), Expect = 6e-74 Identities = 153/400 (38%), Positives = 228/400 (57%), Gaps = 11/400 (2%) Frame = +3 Query: 6 GSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVY 185 G+ GT+V++G +D R+VAVKR+L A +E+Q L SD PN++R + ++D F Y Sbjct: 580 GAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQY 639 Query: 186 ISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSL 365 I++E C +L + ++Q D + +E T L+ +G+ HLHSL Sbjct: 640 IAIELCAATLQEYVEQ------KDFAHLGLEPIT-----------LLHQTTSGLAHLHSL 682 Query: 366 GIIHRDLKPQNVLISK---EGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQ 536 I+HRDLKP N+L+S G + A +SD G+ K+L S S G+ GW APE Sbjct: 683 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 742 Query: 537 LR---RASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIING--HFDLFVVDHIPE 701 L + + T +D+FS GC+ +Y I++G HPFG+ +R NI+ G + D F D + Sbjct: 743 LSEDCKDNPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACNLDCFHSDKHED 802 Query: 702 AV--HLISLLLQPKPDERPTAMYAINHPLFWSPELRLLFLRDTSDRIEKTT-ETDLLNAL 872 + LI ++ P +RP+A + + HP FWS E +L F +D SDRIEK + ++ L Sbjct: 803 VIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPIVRQL 862 Query: 873 ESIGHQAFGGKWREKLDDGLVADVGRYRKYNFESTRDLLRLIRNKSGHYRELPTDLKESL 1052 E G WRE + L D+ ++R Y S RDLLR +RNK HYRELP +++E+L Sbjct: 863 ERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPVEVQETL 922 Query: 1053 GSLPEGFDRYFSSRFPKLLIEVYKVMSVYCKDEEDFRKYF 1172 GS+P+ F RYF+SRFP LL Y+ M + C+ E F+ Y+ Sbjct: 923 GSIPDDFVRYFTSRFPHLLSHTYQAMEL-CRHERLFQTYY 961
>O94537:PPK4_SCHPO Serine/threonine-protein kinase ppk4 precursor - Schizosaccharomyces| pombe (Fission yeast) Length = 1072 Score = 274 bits (701), Expect = 5e-73 Identities = 158/421 (37%), Positives = 233/421 (55%), Gaps = 33/421 (7%) Frame = +3 Query: 6 GSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVY 185 GS+GT+V+ G Y+ REVAVKR+L D+A +EI L SD PNIVR Y + D F+Y Sbjct: 663 GSHGTIVYRGVYEDREVAVKRVLMEFYDLASREITLLQQSDNHPNIVRYYCKQKSDQFLY 722 Query: 186 ISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSL 365 I +E C C+L+DLI++ ++ D+ K S L+ L+ + G+ HLHSL Sbjct: 723 IVIELCKCNLSDLIEKPI--AYDDLFK------------SIDLVSLLYQIAFGVSHLHSL 768 Query: 366 GIIHRDLKPQNVLISKEGS-------LSAKLSDMGISKRLQEDMSSLSHHG-TGYGSSGW 521 ++HRDLKPQN+L+ S + A +SD G+SK+L + SSL + GS GW Sbjct: 769 DLVHRDLKPQNILLVVNNSPNLSKTRVRALISDFGLSKKLDFNQSSLRNTTFEAAGSYGW 828 Query: 522 QAPEQL------------------RRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERD 647 ++PE L R + A D+F+LGC+ +Y +T G HPFG +Y+ + Sbjct: 829 RSPEILSGSLSQQSKEIQVKTREGRIRQASHATDIFALGCIFYYTLTGGMHPFGSHYDCE 888 Query: 648 INIINGHFDLFVVDHIPE----AVHLISLLLQPKPDERPTAMYAINHPLFWSPELRLLFL 815 NI+ G++ L + + E A LI ++ +P +RPT +NHPLFW +L FL Sbjct: 889 GNILKGNYCLVHLQSLGECGVLAADLIEDMIAFEPSKRPTIEVVLNHPLFWDYAKKLDFL 948 Query: 816 RDTSDRIE---KTTETDLLNALESIGHQAFGGKWREKLDDGLVADVGRYRKYNFESTRDL 986 D SDR E + + LL LE+ G W L LV ++G+YRKY+ D+ Sbjct: 949 IDVSDRFEVEERDPPSPLLQMLENNSKSVIGENWTTCLHSSLVDNLGKYRKYDGSKILDI 1008 Query: 987 LRLIRNKSGHYRELPTDLKESLGSLPEGFDRYFSSRFPKLLIEVYKVMSVYCKDEEDFRK 1166 LR++RNK HY++LP ++ LG LP+GF YF +FP LL+ Y ++ +E F++ Sbjct: 1009 LRVLRNKRHHYQDLPESVRRVLGDLPDGFTSYFVEKFPMLLLHCYHLVKDVLYEESQFKR 1068 Query: 1167 Y 1169 Y Sbjct: 1069 Y 1069
>P32361:IRE1_YEAST Serine/threonine-protein kinase/endoribonuclease IRE1 precursor -| Saccharomyces cerevisiae (Baker's yeast) Length = 1115 Score = 273 bits (699), Expect = 9e-73 Identities = 163/441 (36%), Positives = 238/441 (53%), Gaps = 53/441 (12%) Frame = +3 Query: 6 GSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVY 185 GS+GTVVF+GS+ GR VAVKR+L DIA EI+ L SD PN++R Y + D F+Y Sbjct: 683 GSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLY 742 Query: 186 ISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSL 365 I+LE C+ +L DL++ +V +++L + + L+R + +G+ HLHSL Sbjct: 743 IALELCNLNLQDLVES------KNVSDENLKLQKEYNP-----ISLLRQIASGVAHLHSL 791 Query: 366 GIIHRDLKPQNVLISKEGSLSAK-----------LSDMGISKRLQEDMSSL-SHHGTGYG 509 IIHRDLKPQN+L+S +A +SD G+ K+L SS ++ G Sbjct: 792 KIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSG 851 Query: 510 SSGWQAPEQLRRASQ-------------------------------TRAMDLFSLGCLIF 596 +SGW+APE L ++ TR++D+FS+GC+ + Sbjct: 852 TSGWRAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFY 911 Query: 597 YCITKGKHPFGEYYERDINIINGHFDLFVV------DHIPEAVHLISLLLQPKPDERPTA 758 Y ++KGKHPFG+ Y R+ NII G F L + I EA LIS ++ P +RPTA Sbjct: 912 YILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTA 971 Query: 759 MYAINHPLFWSPELRLLFLRDTSDRIE---KTTETDLLNALESIGHQAF-GGKWREKLDD 926 M + HPLFW +L FL SDR+E + + LL ++ G W K D Sbjct: 972 MKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIPSGDWTVKFDK 1031 Query: 927 GLVADVGRYRKYNFESTRDLLRLIRNKSGHYRELPTDLKESLGSLPEGFDRYFSSRFPKL 1106 + ++ RYRKY+ DLLR +RNK H+ +LP D+ E +G +P+GF YF+ RFP L Sbjct: 1032 TFMDNLERYRKYHSSKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGFYDYFTKRFPNL 1091 Query: 1107 LIEVYKVMSVYCKDEEDFRKY 1169 LI VY ++ D++ R++ Sbjct: 1092 LIGVYMIVKENLSDDQILREF 1112
>O75460:ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 precursor -| Homo sapiens (Human) Length = 977 Score = 273 bits (699), Expect = 9e-73 Identities = 154/402 (38%), Positives = 226/402 (56%), Gaps = 13/402 (3%) Frame = +3 Query: 6 GSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVY 185 G+ GT+V+ G +D R+VAVKR+L A +E+Q L SD PN++R + ++D F Y Sbjct: 580 GAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQY 639 Query: 186 ISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSL 365 I++E C +L + ++Q D + +E T L++ +G+ HLHSL Sbjct: 640 IAIELCAATLQEYVEQ------KDFAHLGLEPIT-----------LLQQTTSGLAHLHSL 682 Query: 366 GIIHRDLKPQNVLISK---EGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQ 536 I+HRDLKP N+LIS G + A +SD G+ K+L S S G+ GW APE Sbjct: 683 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 742 Query: 537 LR---RASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPE-- 701 L + + T +D+FS GC+ +Y +++G HPFG+ +R NI+ G L + PE Sbjct: 743 LSEDCKENPTYTVDIFSAGCVFYYVVSEGSHPFGKSLQRQANILLGACSLDCLH--PEKH 800 Query: 702 ----AVHLISLLLQPKPDERPTAMYAINHPLFWSPELRLLFLRDTSDRIEKTT-ETDLLN 866 A LI ++ P +RP+A + HP FWS E +L F +D SDRIEK + + ++ Sbjct: 801 EDVIARELIEKMIAMDPQKRPSANDVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVK 860 Query: 867 ALESIGHQAFGGKWREKLDDGLVADVGRYRKYNFESTRDLLRLIRNKSGHYRELPTDLKE 1046 LE G WRE + D L D+ ++R Y S RDLLR +RNK HYRELP +++E Sbjct: 861 QLERGGRAVVKMDWRENITDPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRE 920 Query: 1047 SLGSLPEGFDRYFSSRFPKLLIEVYKVMSVYCKDEEDFRKYF 1172 +LG+LP+ F YF+SRFP LL Y+ M + C E F+ Y+ Sbjct: 921 TLGTLPDDFVCYFTSRFPHLLAHTYRAMEL-CSHERLFQPYY 961
>Q9Z2E3:ERN2_MOUSE Serine/threonine-protein kinase/endoribonuclease IRE2 precursor - Mus| musculus (Mouse) Length = 911 Score = 272 bits (696), Expect = 2e-72 Identities = 157/400 (39%), Positives = 228/400 (57%), Gaps = 10/400 (2%) Frame = +3 Query: 3 KGSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFV 182 +G+ GT VF G ++GR VAVKRLLR + ++E+Q L SDR PN++R + + F Sbjct: 516 RGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQFH 575 Query: 183 YISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHS 362 YI+LE C SL + VE D++ W GL +L+ M ++G+ HLHS Sbjct: 576 YIALELCQASLQEY-----------VESPDLDRW---GLEPTTVLQQM---MSGLAHLHS 618 Query: 363 LGIIHRDLKPQNVLIS---KEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPE 533 L I+HRDLKP N+L++ +G +SD G+ K+L S S H G+ GW APE Sbjct: 619 LHIVHRDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPE 678 Query: 534 --QLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPE-- 701 QL S T A+D+FS GC+ +Y ++ G HPFGE R NI++G L + Sbjct: 679 LLQLPPDSPTNAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDPCLAQLQEETHDK 738 Query: 702 --AVHLISLLLQPKPDERPTAMYAINHPLFWSPELRLLFLRDTSDRIEKTTETD-LLNAL 872 A+ L+ +L P +RP+A + + HPLFWS L F +D SD +EK + L++AL Sbjct: 739 VVALDLVRAMLSLLPQDRPSAGWVLAHPLFWSRAKELQFFQDVSDWLEKEPDQGPLVSAL 798 Query: 873 ESIGHQAFGGKWREKLDDGLVADVGRYRKYNFESTRDLLRLIRNKSGHYRELPTDLKESL 1052 E+ ++ W + + L AD+ R+R Y S RDLLR +RNK HYRELP +++++L Sbjct: 799 EAGSYKVVREDWHKHISAPLQADLKRFRSYKGTSVRDLLRAMRNKKHHYRELPAEVRQTL 858 Query: 1053 GSLPEGFDRYFSSRFPKLLIEVYKVMSVYCKDEEDFRKYF 1172 G LP GF +YF+ RFP+LL+ ++ M C E F Y+ Sbjct: 859 GQLPAGFIQYFTQRFPRLLLHTHRAMRT-CASESLFLPYY 897
>Q76MJ5:ERN2_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE2 precursor -| Homo sapiens (Human) Length = 925 Score = 271 bits (692), Expect = 6e-72 Identities = 154/403 (38%), Positives = 234/403 (58%), Gaps = 14/403 (3%) Frame = +3 Query: 6 GSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVY 185 G+ GT VF G ++GR VAVKRLLR + ++E+Q L SDR PN++R + ++ F Y Sbjct: 528 GAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHY 587 Query: 186 ISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSL 365 I+LE C SL + ++ D+++ +E P+++ ++ +++G+ HLHSL Sbjct: 588 IALELCRASLQEYVEN------PDLDRGGLE---------PEVV--LQQLMSGLAHLHSL 630 Query: 366 GIIHRDLKPQNVLIS---KEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQ 536 I+HRDLKP N+LI+ +G LSD G+ K+L S S H G+ GW APE Sbjct: 631 HIVHRDLKPGNILITGPDTQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPEL 690 Query: 537 LRRA---SQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPEAV 707 L+ S T A+D+FS GC+ +Y ++ G HPFG+ R NI+ G + + H+ E V Sbjct: 691 LQLLPPNSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTG---VPCLAHLEEEV 747 Query: 708 H-------LISLLLQPKPDERPTAMYAINHPLFWSPELRLLFLRDTSDRIEKTTETD-LL 863 H L++ +L P RP+A + HP FWS +L F +D SD +EK +E + L+ Sbjct: 748 HDKVVARDLVAAMLSLLPQARPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLM 807 Query: 864 NALESIGHQAFGGKWREKLDDGLVADVGRYRKYNFESTRDLLRLIRNKSGHYRELPTDLK 1043 ALE+ G W E + L D+ ++R Y S RDLLR +RNK HYRELP +++ Sbjct: 808 RALEAGGCTVVRDNWHEHISMPLQIDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVR 867 Query: 1044 ESLGSLPEGFDRYFSSRFPKLLIEVYKVMSVYCKDEEDFRKYF 1172 ++LG +P+GF +YF++RFP+LL+ ++VM C E F Y+ Sbjct: 868 QALGQVPDGFVQYFTNRFPQLLLHTHRVMR-SCASESLFLPYY 909
>Q05921:RN5A_MOUSE 2-5A-dependent ribonuclease - Mus musculus (Mouse)| Length = 735 Score = 110 bits (274), Expect = 2e-23 Identities = 111/403 (27%), Positives = 172/403 (42%), Gaps = 14/403 (3%) Frame = +3 Query: 6 GSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVY 185 G++ V+ G YD REVAVK + R ++ KE+ L N+V YG + D +Y Sbjct: 372 GTSEGAVYLGIYDNREVAVK-VFRENSPRGCKEVSCLRDCGDHSNLVAFYGREDDKGCLY 430 Query: 186 ISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSL 365 + + C +L + ++ P VE +D LL + G+ LH Sbjct: 431 VCVSLCEWTLEEFLRL---PREEPVEN------GEDKFAHSILLSIFE----GVQKLHLH 477 Query: 366 GIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRR 545 G H+DL+PQN+LI + + +L+D S R W Q+ R Sbjct: 478 GYSHQDLQPQNILI--DSKKAVRLADFDQSIR-------------------WMGESQMVR 516 Query: 546 ASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPEAVHLISLL 725 DL LG L+ Y + KG+ PF ++ + L + E LI L Sbjct: 517 ------RDLEDLGRLVLYVVMKGEIPFETLKTQNDEV------LLTMSPDEETKDLIHCL 564 Query: 726 LQPKPDERPTAMYAINHPLFWSPELRLLFLRDT---SDRIEKTTETDLLNALESIGHQAF 896 P + + + + HP FW+ E R LR+ SD + ++DLL L+ HQ Sbjct: 565 FSPGENVKNCLVDLLGHPFFWTWENRYRTLRNVGNESDIKVRKCKSDLLRLLQ---HQTL 621 Query: 897 G-----GKWREKLDDGLVADVGRY---RKYN--FESTRDLLRLIRNKSGHY-RELPTDLK 1043 +W K+D ++ ++ + RK N ++ DLL+ IRN H E +K Sbjct: 622 EPPRSFDQWTSKIDKNVMDEMNHFYEKRKKNPYQDTVGDLLKFIRNIGEHINEEKKRGMK 681 Query: 1044 ESLGSLPEGFDRYFSSRFPKLLIEVYKVMSVYCKDEEDFRKYF 1172 E LG RYF FP L+I +YK + E ++RK+F Sbjct: 682 EILGDP----SRYFQETFPDLVIYIYKKLK-----ETEYRKHF 715
>Q05823:RN5A_HUMAN 2-5A-dependent ribonuclease - Homo sapiens (Human)| Length = 741 Score = 89.0 bits (219), Expect = 4e-17 Identities = 96/394 (24%), Positives = 166/394 (42%), Gaps = 11/394 (2%) Frame = +3 Query: 24 VFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERC 203 ++ G Y+ +EVAVK + AQ+E+ L +S + ++V YG + +++ + C Sbjct: 379 IYLGFYEKQEVAVKTFCEG-SPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLC 437 Query: 204 HCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLH-SLGIIHR 380 +L + H DVE + E ++ + + LH S G H+ Sbjct: 438 EQTLEACLDVHRG---EDVENEEDEF----------ARNVLSSIFKAVQELHLSCGYTHQ 484 Query: 381 DLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTR 560 DL+PQN+LI + +A L+D S + D P++++R Sbjct: 485 DLQPQNILI--DSKKAAHLADFDKSIKWAGD------------------PQEVKR----- 519 Query: 561 AMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPKP 740 DL LG L+ Y + KG F + + + ++ + E LI L P Sbjct: 520 --DLEDLGRLVLYVVKKGSISFEDLKAQ------SNEEVVQLSPDEETKDLIHRLFHPGE 571 Query: 741 DERPTAMYAINHPLFWSPELRLLFLRDT---SDRIEKTTETDLLNALE--SIGHQAFGGK 905 R + HP FW+ E R LR+ SD + +E+++L L+ H K Sbjct: 572 HVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDK 631 Query: 906 WREKLDDGLVADVGRY--RKYNF--ESTRDLLRLIRNKSGHY-RELPTDLKESLGSLPEG 1070 W K+++ ++ + ++ ++ NF + DLL+ IRN H E +K +G Sbjct: 632 WTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDP--- 688 Query: 1071 FDRYFSSRFPKLLIEVYKVMSVYCKDEEDFRKYF 1172 YF FP L+I VY + ++RK+F Sbjct: 689 -SLYFQKTFPDLVIYVYTKL-----QNTEYRKHF 716
>Q6P3R8:NEK5_HUMAN Serine/threonine-protein kinase Nek5 - Homo sapiens (Human)| Length = 708 Score = 86.7 bits (213), Expect = 2e-16 Identities = 69/256 (26%), Positives = 116/256 (45%), Gaps = 6/256 (2%) Frame = +3 Query: 30 EGSYDGREVAVKRLLRSHTDIAQKEIQN----LIASDRDPNIVRLYGCDQDDNFVYISLE 197 +G D + +K + I +KE L+ + PNIV + Q++ ++I +E Sbjct: 22 KGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAFFNSFQENGRLFIVME 81 Query: 198 RCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIH 377 +C DL+++ + + L+++D Q+L + G+ H+H I+H Sbjct: 82 --YCDGGDLMKR--------INRQRGVLFSED-----QILGWFVQISLGLKHIHDRKILH 126 Query: 378 RDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQT 557 RD+K QN+ +SK G + AKL D GI++ L M T G+ + +PE + Sbjct: 127 RDIKAQNIFLSKNG-MVAKLGDFGIARVLNNSMELAR---TCIGTPYYLSPEICQNKPYN 182 Query: 558 RAMDLFSLGCLIFYCITKGKHPF--GEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQ 731 D++SLGC+++ T KHPF + + I HF E LIS L Q Sbjct: 183 NKTDIWSLGCVLYELCTL-KHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQ 241 Query: 732 PKPDERPTAMYAINHP 779 P +RP+ + P Sbjct: 242 VSPRDRPSINSILKRP 257
>O00444:PLK4_HUMAN Serine/threonine-protein kinase PLK4 - Homo sapiens (Human)| Length = 970 Score = 85.5 bits (210), Expect = 5e-16 Identities = 73/267 (27%), Positives = 132/267 (49%), Gaps = 8/267 (2%) Frame = +3 Query: 3 KGS-NGTVVFEGSYDGREVAVKRLLRSHTDIAQ--KEIQNLIASD---RDPNIVRLYGCD 164 KGS G E + G EVA+K + + A + +QN + + P+I+ LY Sbjct: 20 KGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYF 79 Query: 165 QDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAG 344 +D N+VY+ LE CH + ++ FS+ E M ++ G Sbjct: 80 EDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEA----------------RHFMHQIITG 123 Query: 345 IVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQ 524 +++LHS GI+HRDL N+L+++ +++ K++D G++ +L+ H T G+ + Sbjct: 124 MLYLHSHGILHRDLTLSNLLLTR--NMNIKIADFGLATQLKMPHEK---HYTLCGTPNYI 178 Query: 525 APEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFG-EYYERDIN-IINGHFDLFVVDHIP 698 +PE R++ D++SLGC+ FY + G+ PF + + +N ++ +++ I Sbjct: 179 SPEIATRSAHGLESDVWSLGCM-FYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSI- 236 Query: 699 EAVHLISLLLQPKPDERPTAMYAINHP 779 EA LI LL+ P +R + ++HP Sbjct: 237 EAKDLIHQLLRRNPADRLSLSSVLDHP 263
>O70405:ULK1_MOUSE Serine/threonine-protein kinase ULK1 - Mus musculus (Mouse)| Length = 1051 Score = 84.7 bits (208), Expect = 8e-16 Identities = 74/229 (32%), Positives = 115/229 (50%), Gaps = 17/229 (7%) Frame = +3 Query: 21 VVFEGSYDGR---EVAVK-----RLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDN 176 VVF+G + + EVAVK L +S T + KEI+ ++ + NIV LY + N Sbjct: 29 VVFKGRHREKHDLEVAVKCINKKNLAKSQT-LLGKEIK-ILKELKHENIVALYDFQEMAN 86 Query: 177 FVYISLERCHCS-LADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVH 353 VY+ +E C+ LAD + HT + S+ ++L +AG + Sbjct: 87 SVYLVMEYCNGGDLADYL--HTMRTLSE-----------------DTVRLFLQQIAGAMR 127 Query: 354 L-HSLGIIHRDLKPQNVLISKEG-------SLSAKLSDMGISKRLQEDMSSLSHHGTGYG 509 L HS GIIHRDLKPQN+L+S G ++ K++D G ++ LQ +M + T G Sbjct: 128 LLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMA----ATLCG 183 Query: 510 SSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINI 656 S + APE + DL+S+G +++ C+T GK PF +D+ + Sbjct: 184 SPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLT-GKAPFQASSPQDLRL 231
>Q64702:PLK4_MOUSE Serine/threonine-protein kinase PLK4 - Mus musculus (Mouse)| Length = 925 Score = 84.7 bits (208), Expect = 8e-16 Identities = 72/272 (26%), Positives = 128/272 (47%), Gaps = 13/272 (4%) Frame = +3 Query: 3 KGS-NGTVVFEGSYDGREVAVKRLLRSHTDIAQ--KEIQNLIASD---RDPNIVRLYGCD 164 KGS G E + G EVA+K + + A + +QN + + P+++ LY Sbjct: 20 KGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYF 79 Query: 165 QDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAG 344 +D+N+VY+ LE CH + ++ FS+ E M ++ G Sbjct: 80 EDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREA----------------RHFMHQIITG 123 Query: 345 IVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQ 524 +++LHS GI+HRDL N+L+++ +++ K++D G++ +L H T G+ + Sbjct: 124 MLYLHSHGILHRDLTLSNILLTR--NMNIKIADFGLATQLNMPHEK---HYTLCGTPNYI 178 Query: 525 APEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP-- 698 +PE R++ D++SLGC+ FY + G+ PF D + + + V+ Sbjct: 179 SPEIATRSAHGLESDIWSLGCM-FYTLLIGRPPF------DTDTVKNTLNKVVLADYEMP 231 Query: 699 -----EAVHLISLLLQPKPDERPTAMYAINHP 779 EA LI LL+ P +R + ++HP Sbjct: 232 AFLSREAQDLIHQLLRRNPADRLSLSSVLDHP 263
>Q2TA25:PLK1_BOVIN Serine/threonine-protein kinase PLK1 - Bos taurus (Bovine)| Length = 602 Score = 84.3 bits (207), Expect = 1e-15 Identities = 67/252 (26%), Positives = 116/252 (46%), Gaps = 1/252 (0%) Frame = +3 Query: 39 YDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLA 218 + G+ V LL+ H ++ S ++V +G +D++FV++ LE C Sbjct: 77 FAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCR--RR 134 Query: 219 DLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQN 398 L++ H + L P+ +R +V G +LH +IHRDLK N Sbjct: 135 SLLELHK---------------RRKALTEPEARYYLRQIVLGCQYLHGNRVIHRDLKLGN 179 Query: 399 VLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFS 578 + ++++ L K+ D G++ +++ D T G+ + APE L + + +D++S Sbjct: 180 LFLNED--LEVKIGDFGLATKVEYDG---ERKKTLCGTPNYIAPEVLSKKGHSFEVDVWS 234 Query: 579 LGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHI-PEAVHLISLLLQPKPDERPT 755 +GC I Y + GK PF ++ + + + + HI P A LI +LQP P RPT Sbjct: 235 IGC-IMYTLLVGKPPFETSCLKETYLRIKNNEYSIPKHINPVASSLIKKMLQPDPTARPT 293 Query: 756 AMYAINHPLFWS 791 +N F S Sbjct: 294 IHELLNDEFFTS 305
>Q19192:E2AK3_CAEEL Eukaryotic translation initiation factor 2-alpha kinase precursor -| Caenorhabditis elegans Length = 1077 Score = 84.3 bits (207), Expect = 1e-15 Identities = 71/277 (25%), Positives = 122/277 (44%), Gaps = 21/277 (7%) Frame = +3 Query: 9 SNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQN---LIASDRDPNIVRLYGCDQDDNF 179 S G +GS D AVK + I + I N ++ ++ VR D + Sbjct: 820 SGGIEFVDGSDDVDNEAVKETKKEIAVIEELSIHNRAMIVETENQELEVRERNDTGDCAY 879 Query: 180 VYISLERC-HCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHL 356 +YI ++ C +L D I++ T + P + ++ + +G+ +L Sbjct: 880 LYIVMQLCAEKTLEDWIRRSK---------------TMESRPLFTMKNWIKQLASGLEYL 924 Query: 357 HSLGIIHRDLKPQNV---LISKEGSLSAKLSDMGISKR--------LQEDMSSLSHHGTG 503 H+ G IHRDLKP NV L S G K+ D+G++ + +++D S + H Sbjct: 925 HNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLATKTDGAPKITVRQDSDSSAKHTKN 984 Query: 504 YGSSGWQAPEQLRRASQTRAMDLFSLG------CLIFYCITKGKHPFGEYYERDINIING 665 G+ + +PEQL+ T +D+F+LG + F ++ H F ++ + DI I Sbjct: 985 VGTRSYMSPEQLKHQQYTEKVDIFALGLVATELIISFSTASERIHTFADFQKGDIPAI-- 1042 Query: 666 HFDLFVVDHIPEAVHLISLLLQPKPDERPTAMYAINH 776 +D++PE+ + L +P ERPTA H Sbjct: 1043 ------LDNVPESRDFLLQLTSLEPSERPTAHEVATH 1073
>Q4FZD7:PLK5_MOUSE Serine/threonine-protein kinase PLK5 - Mus musculus (Mouse)| Length = 595 Score = 83.6 bits (205), Expect = 2e-15 Identities = 68/224 (30%), Positives = 108/224 (48%), Gaps = 5/224 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 R NIV + D + VY+ LE C + S + V K+ + L P Sbjct: 83 RHRNIVAFHAHFADRDHVYMVLEYC-----------SRQSLAHVLKV------RRTLTEP 125 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLS 488 ++ +R +V+G+ +LH I+HRDLKP N ++K ++ K+ D+G++ R+ + Sbjct: 126 EVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNK--NMEVKIGDLGLAARVG---PAGR 180 Query: 489 HHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-----GEYYERDIN 653 H G+ +QAPE + R + D+++LGC I Y + G PF E Y+ N Sbjct: 181 CHRVLCGTPNFQAPEVVSRNGHSCKSDIWALGC-IMYTVLTGTPPFAAAPLSEMYQ---N 236 Query: 654 IINGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMYAINHPLF 785 I +GH+ L P A LI+ LL P P ERP+ + + F Sbjct: 237 IRDGHY-LEPTHLSPSARSLIARLLAPDPAERPSLDHLLQDDFF 279
>Q9FZ36:M3K2_ARATH Mitogen-activated protein kinase kinase kinase 2 - Arabidopsis| thaliana (Mouse-ear cress) Length = 651 Score = 83.2 bits (204), Expect = 2e-15 Identities = 74/277 (26%), Positives = 131/277 (47%), Gaps = 18/277 (6%) Frame = +3 Query: 3 KGSNGTVVFEGSYDGREV-AVKRLL-----------RSHTDIAQKEIQNLIASDRDPNIV 146 +G+ GTV + D E+ AVK++L ++H ++E++ L+ + PNIV Sbjct: 76 RGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVK-LLKNLSHPNIV 134 Query: 147 RLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLM 326 R G ++D + I LE F I L P + Sbjct: 135 RYLGTVREDETLNILLE-----------------FVPGGSISSLLEKFGAFPESVVRTYT 177 Query: 327 RDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGY 506 ++ G+ +LH+ I+HRD+K N+L+ +G + KL+D G SK++ E ++++S + Sbjct: 178 NQLLLGLEYLHNHAIMHRDIKGANILVDNQGCI--KLADFGASKQVAE-LATISGAKSMK 234 Query: 507 GSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYER-----DINIINGHF 671 G+ W APE + + + + D++S+GC + +T GK P+ + Y+ I H Sbjct: 235 GTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVT-GKAPWSQQYKEIAAIFHIGTTKSHP 293 Query: 672 DLFVVDHI-PEAVHLISLLLQPKPDERPTAMYAINHP 779 + D+I +A + LQ +P+ RPTA + HP Sbjct: 294 P--IPDNISSDANDFLLKCLQQEPNLRPTASELLKHP 328
>Q7TSC3:NEK5_MOUSE Serine/threonine-protein kinase Nek5 - Mus musculus (Mouse)| Length = 627 Score = 82.8 bits (203), Expect = 3e-15 Identities = 67/262 (25%), Positives = 119/262 (45%), Gaps = 2/262 (0%) Frame = +3 Query: 60 VKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHT 239 +K + + A K L+A PNIV + Q++ ++I +E +C DL+Q+ Sbjct: 32 IKEISLTKEKEASKNEVILLARMEHPNIVTFFSSFQENGRLFIVME--YCDGGDLMQR-- 87 Query: 240 DPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEG 419 +++ ++++D Q+L + G+ H+H I+HRD+K QN+ +SK G Sbjct: 88 ------IQRQRGVMFSED-----QILCWFVQISLGLKHIHDRKILHRDIKSQNIFLSKNG 136 Query: 420 SLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFY 599 + AKL D G ++ L + M T G+ + +PE + D++SLGC+++ Sbjct: 137 -MVAKLGDFGTARTLNDSMELAQ---TCAGTPYYLSPEICQNRPYNNKTDIWSLGCVLYE 192 Query: 600 CITKGKHPF--GEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMYAIN 773 T KHPF ++ + I G + LI L + P +RP+ + Sbjct: 193 LCTL-KHPFESNNFHHLVLKICQGRVAPISPHFSRDLQSLIPQLFRVSPQDRPSVTSLLK 251 Query: 774 HPLFWSPELRLLFLRDTSDRIE 839 P + R L+ S RI+ Sbjct: 252 RPFLETLIARSLYPEVCSRRIQ 273
>O75385:ULK1_HUMAN Serine/threonine-protein kinase ULK1 - Homo sapiens (Human)| Length = 1050 Score = 82.4 bits (202), Expect = 4e-15 Identities = 87/284 (30%), Positives = 133/284 (46%), Gaps = 23/284 (8%) Frame = +3 Query: 21 VVFEGSYDGR---EVAVK-----RLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDN 176 VVF+G + + EVAVK L +S T + KEI+ ++ + NIV LY + N Sbjct: 29 VVFKGRHREKHDLEVAVKCINKKNLAKSQT-LLGKEIK-ILKELKHENIVALYDFQEMAN 86 Query: 177 FVYISLERCHCS-LADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVH 353 VY+ +E C+ LAD + H + S+ ++L +AG + Sbjct: 87 SVYLVMEYCNGGDLADYL--HAMRTLSE-----------------DTIRLFLQQIAGAMR 127 Query: 354 L-HSLGIIHRDLKPQNVLIS-------KEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYG 509 L HS GIIHRDLKPQN+L+S S+ K++D G ++ LQ +M + T G Sbjct: 128 LLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMA----ATLCG 183 Query: 510 SSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVD 689 S + APE + DL+S+G +++ C+T GK PF +D+ + + +V Sbjct: 184 SPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLT-GKAPFQASSPQDLRLFY-EKNKTLVP 241 Query: 690 HIPEAV-----HLISLLLQPKPDERPTAMYAINHP-LFWSPELR 803 IP L+ LLQ +R +HP L SP +R Sbjct: 242 TIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVR 285
>O15865:CDPK2_PLAFK Calcium-dependent protein kinase 2 - Plasmodium falciparum (isolate| K1 / Thailand) Length = 513 Score = 82.4 bits (202), Expect = 4e-15 Identities = 69/223 (30%), Positives = 104/223 (46%), Gaps = 8/223 (3%) Frame = +3 Query: 135 PNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQL 314 PNIV+LY ++DN++Y+ +E C S E D + Sbjct: 127 PNIVKLYETYENDNYIYLIMELC----------------SGRELFD-SIIENGSFTEKNA 169 Query: 315 LKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLS-AKLSDMGISKRLQEDMSSLSH 491 +M+ + + I +LHSL I+HRDLKP+N L E S K+ D G+SK L + + Sbjct: 170 ATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTK 229 Query: 492 HGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINII---- 659 GT Y + AP Q+ + D++S G +I Y + G PF Y + D ++ Sbjct: 230 AGTPY----YVAP-QVLDGKYDKKCDIWSSG-VIMYTLLCGYPPF--YGDTDNEVLKKVK 281 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G F + D +A +LI+ LL P+ER T A+NHP Sbjct: 282 KGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHP 324
>Q8ICR0:CDPK2_PLAF7 Calcium-dependent protein kinase 2 - Plasmodium falciparum (isolate| 3D7) Length = 509 Score = 82.4 bits (202), Expect = 4e-15 Identities = 69/223 (30%), Positives = 104/223 (46%), Gaps = 8/223 (3%) Frame = +3 Query: 135 PNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQL 314 PNIV+LY ++DN++Y+ +E C S E D + Sbjct: 127 PNIVKLYETYENDNYIYLIMELC----------------SGRELFD-SIIENGSFTEKNA 169 Query: 315 LKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLS-AKLSDMGISKRLQEDMSSLSH 491 +M+ + + I +LHSL I+HRDLKP+N L E S K+ D G+SK L + + Sbjct: 170 ATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTK 229 Query: 492 HGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINII---- 659 GT Y + AP Q+ + D++S G +I Y + G PF Y + D ++ Sbjct: 230 AGTPY----YVAP-QVLDGKYDKKCDIWSSG-VIMYTLLCGYPPF--YGDTDNEVLKKVK 281 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G F + D +A +LI+ LL P+ER T A+NHP Sbjct: 282 KGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHP 324
>P28829:BYR2_SCHPO Protein kinase byr2 - Schizosaccharomyces pombe (Fission yeast)| Length = 659 Score = 82.4 bits (202), Expect = 4e-15 Identities = 50/157 (31%), Positives = 83/157 (52%), Gaps = 5/157 (3%) Frame = +3 Query: 324 MRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHG-- 497 ++ + G+ +LHS GI+HRD+K N+L+ +G + K+SD GISK+L+ + +S G Sbjct: 503 IKQTLKGLEYLHSRGIVHRDIKGANILVDNKGKI--KISDFGISKKLELNSTSTKTGGAR 560 Query: 498 -TGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFG--EYYERDINIINGH 668 + GSS W APE +++ T D++SLGCL+ +T KHP+ + + I Sbjct: 561 PSFQGSSFWMAPEVVKQTMHTEKTDIWSLGCLVIEMLT-SKHPYPNCDQMQAIFRIGENI 619 Query: 669 FDLFVVDHIPEAVHLISLLLQPKPDERPTAMYAINHP 779 F + A+ + + RPTA ++HP Sbjct: 620 LPEFPSNISSSAIDFLEKTFAIDCNLRPTASELLSHP 656
>O22040:ANP1_ARATH Mitogen-activated protein kinase kinase kinase ANP1 - Arabidopsis| thaliana (Mouse-ear cress) Length = 666 Score = 82.4 bits (202), Expect = 4e-15 Identities = 75/279 (26%), Positives = 137/279 (49%), Gaps = 20/279 (7%) Frame = +3 Query: 3 KGSNGTVVFEGSYDGREV-AVKRLL-----------RSHTDIAQKEIQNLIASDRDPNIV 146 +G+ GTV + D E+ AVK++L ++H ++E++ L+ + PNIV Sbjct: 77 RGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVK-LLKNLSHPNIV 135 Query: 147 RLYGCDQDDNFVYISLERCHC-SLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKL 323 R G ++D+ + I LE S++ L+++ F + V +T Sbjct: 136 RYLGTVREDDTLNILLEFVPGGSISSLLEK-----FGPFPESVVRTYT------------ 178 Query: 324 MRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTG 503 R ++ G+ +LH+ I+HRD+K N+L+ +G + KL+D G SK++ E +++++ + Sbjct: 179 -RQLLLGLEYLHNHAIMHRDIKGANILVDNKGCI--KLADFGASKQVAE-LATMTGAKSM 234 Query: 504 YGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFV 683 G+ W APE + + + + D++S+GC + +T GK P+ + Y+ I F Sbjct: 235 KGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVT-GKAPWSQQYKEVAAIF---FIGTT 290 Query: 684 VDHIP-------EAVHLISLLLQPKPDERPTAMYAINHP 779 H P +A + LQ P+ RPTA + HP Sbjct: 291 KSHPPIPDTLSSDAKDFLLKCLQEVPNLRPTASELLKHP 329
>Q8T0S6:HIPPO_DROME Serine/threonine-protein kinase hippo - Drosophila melanogaster| (Fruit fly) Length = 669 Score = 81.6 bits (200), Expect = 7e-15 Identities = 71/272 (26%), Positives = 123/272 (45%), Gaps = 14/272 (5%) Frame = +3 Query: 3 KGSNGTVVFEGSYDGREVAVKRLLRSHTDIAQ--KEIQNLIASDRDPNIVRLYGCDQDDN 176 +GS G+V + + +L+ +D+ + KEI + D P +VR YG Sbjct: 50 EGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIMQQCD-SPYVVRYYGSYFKQY 108 Query: 177 FVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHL 356 ++I +E C S SD+ ++ + T+D ++ ++ D + G+V+L Sbjct: 109 DLWICMEYCGAG-----------SVSDIMRLRKKTLTED-----EIATILSDTLQGLVYL 152 Query: 357 HSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQ 536 H IHRD+K N+L++ EG AKL+D G++ +L + M+ T G+ W APE Sbjct: 153 HLRRKIHRDIKAANILLNTEG--YAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEV 207 Query: 537 LRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------ 698 + D++SLG + +GK P+GE I+ +F++ P Sbjct: 208 IEEIGYDCVADIWSLGITALE-MAEGKPPYGE--------IHPMRAIFMIPQKPPPSFRE 258 Query: 699 ------EAVHLISLLLQPKPDERPTAMYAINH 776 E + +S L +PD+R TA + H Sbjct: 259 PDRWSTEFIDFVSKCLVKEPDDRATATELLEH 290
>O22042:M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 - Arabidopsis| thaliana (Mouse-ear cress) Length = 651 Score = 80.9 bits (198), Expect = 1e-14 Identities = 63/246 (25%), Positives = 118/246 (47%), Gaps = 5/246 (2%) Frame = +3 Query: 57 AVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQH 236 A K + H ++E+Q L+ + PNIVR G ++ + + I +E Sbjct: 106 ASKEKTQGHIRELEEEVQ-LLKNLSHPNIVRYLGTVRESDSLNILME------------- 151 Query: 237 TDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKE 416 F I L P P ++ + ++ G+ +LH+ GI+HRD+K N+L+ + Sbjct: 152 ----FVPGGSISSLLEKFGSFPEPVIIMYTKQLLLGLEYLHNNGIMHRDIKGANILVDNK 207 Query: 417 GSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIF 596 G + +L+D G SK++ E +++++ + G+ W APE + + + + D++S+GC + Sbjct: 208 GCI--RLADFGASKKVVE-LATVNGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVI 264 Query: 597 YCITKGKHPFGEYYERDINIIN-----GHFDLFVVDHIPEAVHLISLLLQPKPDERPTAM 761 T GK P+ E Y++ +++ H + D PEA + L +P R +A Sbjct: 265 EMAT-GKPPWSEQYQQFAAVLHIGRTKAHPPI-PEDLSPEAKDFLMKCLHKEPSLRLSAT 322 Query: 762 YAINHP 779 + HP Sbjct: 323 ELLQHP 328
>Q9C098:DCLK3_HUMAN Serine/threonine-protein kinase DCLK3 - Homo sapiens (Human)| Length = 648 Score = 80.9 bits (198), Expect = 1e-14 Identities = 74/249 (29%), Positives = 119/249 (47%), Gaps = 10/249 (4%) Frame = +3 Query: 63 KRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTD 242 K L+ D+ EI +I S PNIV+L+ + D +Y+ LE Q D Sbjct: 389 KSRLKGKEDMVDSEIL-IIQSLSHPNIVKLHEVYETDMEIYLILEYV---------QGGD 438 Query: 243 PSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI--SKE 416 + +E + P P ++ D+ +VH+H I+HRDLKP+N+L+ +++ Sbjct: 439 LFDAIIESVK--------FPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNED 490 Query: 417 GSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIF 596 S + KL+D G++K + + ++ G+ + APE L +D+++ G +I Sbjct: 491 KSTTLKLADFGLAKHVVRPIFTVC------GTPTYVAPEILSEKGYGLEVDMWAAG-VIL 543 Query: 597 YCITKGKHPFGEYYERD----INIIN-GHFDLF--VVDHIPEAV-HLISLLLQPKPDERP 752 Y + G PF ERD NII GHF+ D+I +A L+S LL P +R Sbjct: 544 YILLCGFPPF-RSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRY 602 Query: 753 TAMYAINHP 779 TA + HP Sbjct: 603 TAHQVLQHP 611
>P53350:PLK1_HUMAN Serine/threonine-protein kinase PLK1 - Homo sapiens (Human)| Length = 603 Score = 80.5 bits (197), Expect = 1e-14 Identities = 66/252 (26%), Positives = 114/252 (45%), Gaps = 1/252 (0%) Frame = +3 Query: 39 YDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLA 218 + G+ V LL+ H ++ S ++V +G +D++FV++ LE C Sbjct: 79 FAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCR--RR 136 Query: 219 DLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQN 398 L++ H + L P+ +R +V G +LH +IHRDLK N Sbjct: 137 SLLELHK---------------RRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGN 181 Query: 399 VLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFS 578 + ++++ L K+ D G++ +++ D T G+ + APE L + + +D++S Sbjct: 182 LFLNED--LEVKIGDFGLATKVEYDG---ERKKTLCGTPNYIAPEVLSKKGHSFEVDVWS 236 Query: 579 LGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHI-PEAVHLISLLLQPKPDERPT 755 +GC I Y + GK PF ++ + + + HI P A LI +LQ P RPT Sbjct: 237 IGC-IMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPT 295 Query: 756 AMYAINHPLFWS 791 +N F S Sbjct: 296 INELLNDEFFTS 307
>Q9S2C0:PKSC_STRCO Serine/threonine protein kinase pksC - Streptomyces coelicolor| Length = 556 Score = 80.5 bits (197), Expect = 1e-14 Identities = 59/222 (26%), Positives = 107/222 (48%), Gaps = 15/222 (6%) Frame = +3 Query: 6 GSNGTVVFEGSYDG---REVAVKRLLRSHTDIAQKEI--------QNLIASDRDPNIVRL 152 G G +YD R+VA+K L HT++ +++ +A NIV + Sbjct: 27 GEGGMASVHLAYDSVLDRQVAIKTL---HTELGREQAFRERFRREAQAVAKLTHTNIVSV 83 Query: 153 YGCDQDD----NFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLK 320 + +DD YI +E + +D ++ Q +P+ + LK Sbjct: 84 FDTGEDDLDGMTTPYIVMEYVEGRPLGSV-------------LDEDVRQQGAMPADKALK 130 Query: 321 LMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT 500 + DV+A + H +G++HRD+KP NV+++K G + K+ D GI++ +Q ++S++ G Sbjct: 131 ITADVLAALEISHEMGLVHRDIKPGNVMMTKRGVV--KVMDFGIARAMQSGVTSMTQTGM 188 Query: 501 GYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF 626 G+ + +PEQ DL+S+G ++F +T G+ PF Sbjct: 189 VVGTPQYLSPEQALGRGVDARSDLYSVGIMLFQLVT-GRLPF 229
>P43637:KGS9_YEAST Probable serine/threonine-protein kinase YGL179C - Saccharomyces| cerevisiae (Baker's yeast) Length = 560 Score = 80.5 bits (197), Expect = 1e-14 Identities = 69/230 (30%), Positives = 109/230 (47%), Gaps = 26/230 (11%) Frame = +3 Query: 138 NIVRLYGC--DQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQ 311 N+V LY D + VY+ LE C + K++++ L Q Sbjct: 115 NVVELYEILNDPESTKVYLVLEYC---------SRGPVKWCPENKMEIKAVGPSILTFQQ 165 Query: 312 LLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSL-- 485 K++ DVV+G+ +LHS GI HRD+KP N+LIS G++ K+SD G++ +++ Sbjct: 166 SRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTV--KISDFGVAMSTATGSTNIQS 223 Query: 486 SHH----GTGYGSSGWQAPEQL---RRASQTRAMDLFSLGCLIFYCITKGKHPFG----- 629 SH G+ + APE + S + A+D++SLG I YC+ GK PF Sbjct: 224 SHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTI-YCLLFGKLPFNANSGL 282 Query: 630 EYYERDIN----------IINGHFDLFVVDHIPEAVHLISLLLQPKPDER 749 E ++ IN ++NG ++ +A L+ LLQ PD+R Sbjct: 283 ELFDSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPDKR 332
>Q9LX30:GCN2_ARATH Probable serine/threonine-protein kinase GCN2 - Arabidopsis thaliana| (Mouse-ear cress) Length = 1241 Score = 80.5 bits (197), Expect = 1e-14 Identities = 73/253 (28%), Positives = 110/253 (43%), Gaps = 23/253 (9%) Frame = +3 Query: 162 DQDDN----FVYISLERCHCSLADLIQQ--HTDPSFSDVEKIDVELWTQDGLPSPQLLKL 323 +QD+N ++YI +E C +L + + H D F+ W L Sbjct: 527 EQDNNLESTYLYIQMEYCPRTLRQVFESYNHFDKDFA---------W-----------HL 566 Query: 324 MRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRL------QEDMSSL 485 +R +V G+ H+H GIIHRD P N+ + K+ D G++K L Q+ S Sbjct: 567 IRQIVEGLAHIHGQGIIHRDFTPNNIFFDARNDI--KIGDFGLAKFLKLEQLDQDGGFST 624 Query: 486 SHHGTGYGSSG------WQAPE-QLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYER 644 G+G S+G + APE + D++SLG + F + HPFG ER Sbjct: 625 DVAGSGVDSTGQAGTYFYTAPEIEQDWPKIDEKADMYSLGVVFF----ELWHPFGTAMER 680 Query: 645 DINIIN----GHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMYAINHPLFWSPELRLLF 812 + + N G L V+ PE L+ L+ P P +RP+A + H E LL Sbjct: 681 HVILTNLKLKGELPLKWVNEFPEQASLLRRLMSPSPSDRPSATELLKHAFPPRMESELL- 739 Query: 813 LRDTSDRIEKTTE 851 D RI +T+E Sbjct: 740 --DNILRIMQTSE 750
>Q6RET6:CCAMK_PEA Calcium and calcium/calmodulin-dependent serine/threonine-protein| kinase - Pisum sativum (Garden pea) Length = 527 Score = 80.5 bits (197), Expect = 1e-14 Identities = 76/268 (28%), Positives = 120/268 (44%), Gaps = 10/268 (3%) Frame = +3 Query: 6 GSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVY 185 G N T R+V+V L ++ + + I ++ PN++ LY +D N V+ Sbjct: 73 GENSTETMMKFPTMRQVSVSDALLTNEILVMRRIVENVSPH--PNVIDLYDVYEDTNGVH 130 Query: 186 ISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSL 365 + LE C S E D + QD + ++ +VAG+ +H Sbjct: 131 LVLELC----------------SGGELFD-RIVAQDKYSETEASTVVHQIVAGLEAIHRA 173 Query: 366 GIIHRDLKPQNVL---ISKEGSLSAKLSDMGIS--KRLQEDMSSLSHHGTGYGSSGWQAP 530 IIHRDLKP+N L + K+ SL K+ D G+S + + + L +GS + +P Sbjct: 174 NIIHRDLKPENCLFLDVGKDSSL--KIMDFGLSSVEEFTDPVVGL------FGSIDYVSP 225 Query: 531 EQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDIN--IINGHFDLFVVDH---I 695 E L + T D++SLG +I Y + G PF R I+NG+F + Sbjct: 226 EALSQGKITTKSDMWSLG-VILYILLSGYPPFIAQNNRQKQQMILNGNFSFYEKTWKGIS 284 Query: 696 PEAVHLISLLLQPKPDERPTAMYAINHP 779 A +LIS LL P +RP+A ++ P Sbjct: 285 QSAKNLISSLLTVDPAKRPSAQELLSDP 312
>O34507:PRKC_BACSU Serine/threonine-protein kinase prkC - Bacillus subtilis| Length = 648 Score = 80.1 bits (196), Expect = 2e-14 Identities = 61/201 (30%), Positives = 103/201 (51%), Gaps = 8/201 (3%) Frame = +3 Query: 48 REVAVKRLLRSHTDIAQ------KEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHC 209 REVA+K L + + + +E Q+ + D PNIV +Y ++D+ YI +E Sbjct: 35 REVAIKILRFDYANDNEFIRRFRREAQSASSLDH-PNIVSIYDLGEEDDIYYIVMEY--- 90 Query: 210 SLADLIQQHTDPSFSDVEKIDV-ELWTQDGLPSP-QLLKLMRDVVAGIVHLHSLGIIHRD 383 VE + + E T +G P + L +M +V+ I H H I+HRD Sbjct: 91 ----------------VEGMTLKEYITANGPLHPKEALNIMEQIVSAIAHAHQNQIVHRD 134 Query: 384 LKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRA 563 +KP N+LI G++ K++D GI+ L ++++H + GS + +PEQ R T+ Sbjct: 135 IKPHNILIDHMGNI--KVTDFGIATALSS--TTITHTNSVLGSVHYLSPEQARGGLATKK 190 Query: 564 MDLFSLGCLIFYCITKGKHPF 626 D+++LG ++F +T G+ PF Sbjct: 191 SDIYALGIVLFELLT-GRIPF 210
>Q62673:PLK1_RAT Serine/threonine-protein kinase PLK1 - Rattus norvegicus (Rat)| Length = 603 Score = 80.1 bits (196), Expect = 2e-14 Identities = 65/252 (25%), Positives = 113/252 (44%), Gaps = 1/252 (0%) Frame = +3 Query: 39 YDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLA 218 + G+ V LL+ H ++ S ++V +G +D +FV++ LE C Sbjct: 79 FPGKIVPKSLLLKPHQKEKMSMETSIHRSLEHQHVVGFHGFFEDSDFVFVVLELCR--RR 136 Query: 219 DLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQN 398 L++ H + L P+ +R +V G +LH +IHRDLK N Sbjct: 137 SLLELHK---------------RRKALTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGN 181 Query: 399 VLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFS 578 + ++++ L K+ D G++ +++ + T G+ + APE L + + +D++S Sbjct: 182 LFLNED--LEVKIGDFGLATKVEYEG---ERKKTLCGTPNYIAPEVLSKKGHSFEVDVWS 236 Query: 579 LGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHI-PEAVHLISLLLQPKPDERPT 755 +GC I Y + GK PF ++ + + + HI P A LI +LQ P RPT Sbjct: 237 IGC-IMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPAARPT 295 Query: 756 AMYAINHPLFWS 791 +N F S Sbjct: 296 IHELLNDEFFTS 307
>Q5QN75:M2K1_ORYSJ Mitogen-activated protein kinase kinase 1 - Oryza sativa subsp.| japonica (Rice) Length = 355 Score = 79.7 bits (195), Expect = 2e-14 Identities = 81/294 (27%), Positives = 135/294 (45%), Gaps = 15/294 (5%) Frame = +3 Query: 3 KGSNGTV-VFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQD--- 170 KGS G V + + G A+K + + + +K+I + ++ + C Q Sbjct: 79 KGSGGIVQLVRHKWVGTLYALKGIQMNIQEAVRKQIVQELKINQATQNAHIVLCHQSFYH 138 Query: 171 DNFVYISLERC-HCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGI 347 + +Y+ LE SLAD+I+Q + P L L + V+ G+ Sbjct: 139 NGVIYLVLEYMDRGSLADIIKQVKT------------------ILEPYLAVLCKQVLEGL 180 Query: 348 VHLH-SLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQ 524 ++LH +IHRD+KP N+L++++G + K++D G+S L SS+ T G+ + Sbjct: 181 LYLHHERHVIHRDIKPSNLLVNRKGEV--KITDFGVSAVL---ASSMGQRDTFVGTYNYM 235 Query: 525 APEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF----GE----YYERDINIINGHFDLF 680 APE++ +S D++SLG +I C G+ P+ GE +YE I++ Sbjct: 236 APERISGSSYDYKSDIWSLGLVILECAI-GRFPYIPSEGEGWLSFYELLEAIVDQPPPSA 294 Query: 681 VVDHI-PEAVHLISLLLQPKPDERPTAMYAINHPLFWSPELRLLFLRDTSDRIE 839 D PE IS +Q P ER +A +NHP E + L LR + +E Sbjct: 295 PADQFSPEFCAFISSCIQKDPAERMSASELLNHPFIKKFEDKDLDLRILVESLE 348
>P41892:CDC7_SCHPO Cell division control protein 7 - Schizosaccharomyces pombe| (Fission yeast) Length = 1062 Score = 79.7 bits (195), Expect = 2e-14 Identities = 74/276 (26%), Positives = 129/276 (46%), Gaps = 8/276 (2%) Frame = +3 Query: 48 REVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERC-HCSLADL 224 ++V + ++L+S + + EI L D PNIV+ G Q ++ + I LE C + SL + Sbjct: 38 KKVKLSKMLKSDLSVIKMEIDLLKNLDH-PNIVKYRGSYQTNDSLCIILEYCENGSLRSI 96 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + +F + + V L+T V+ G+++LH+ G+IHRD+K N+L Sbjct: 97 CK-----NFGKIPENLVALYTFQ-------------VLQGLLYLHNQGVIHRDIKGANIL 138 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 +K+G++ KL+D G++ ++ ++L H GS W APE + T A D++S+G Sbjct: 139 TTKDGTI--KLADFGVATKI----NALEDHSV-VGSPYWMAPEVIELVGATTASDIWSVG 191 Query: 585 CLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP-------EAVHLISLLLQPKPD 743 C + + G P YY D++ + F + +H P A + Q P+ Sbjct: 192 CTVIE-LLDGNPP---YY--DLDPTSALFRMVKDEHPPLPSNISSAAKSFLMQCFQKDPN 245 Query: 744 ERPTAMYAINHPLFWSPELRLLFLRDTSDRIEKTTE 851 R + HP + F D D ++K E Sbjct: 246 LRIKTRKLLKHPWVIMNQTSSKF-SDAIDEVQKYNE 280
>Q9CEF5:PKNB_LACLA Probable serine/threonine-protein kinase pknB - Lactococcus lactis| subsp. lactis (Streptococcus lactis) Length = 627 Score = 79.3 bits (194), Expect = 3e-14 Identities = 61/205 (29%), Positives = 107/205 (52%), Gaps = 6/205 (2%) Frame = +3 Query: 30 EGSYDGREVAVKRLLRSH---TDIAQKEIQN---LIASDRDPNIVRLYGCDQDDNFVYIS 191 E ++ G + ++LRS+ DIA Q +A PNIV + + ++ YI Sbjct: 30 EDTFLGDRLVAIKVLRSNFENDDIAIARFQREAFAMAELSHPNIVGISDVGEFESQQYIV 89 Query: 192 LERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGI 371 +E F D + + L + + ++++ ++++ + HS GI Sbjct: 90 ME-----------------FVDGMTLKQYINQNAPLANDEAIEIITEILSAMDMAHSHGI 132 Query: 372 IHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRAS 551 IHRDLKPQNVL+S G++ K++D GI+K L E +SL+ T +GS + +PEQ R ++ Sbjct: 133 IHRDLKPQNVLVSSSGTV--KVTDFGIAKALSE--TSLTQTNTMFGSVHYLSPEQARGSN 188 Query: 552 QTRAMDLFSLGCLIFYCITKGKHPF 626 T D++++G ++F +T G+ PF Sbjct: 189 ATVQSDIYAIGIILFELLT-GQIPF 212
>Q39008:M3K1_ARATH Mitogen-activated protein kinase kinase kinase 1 - Arabidopsis| thaliana (Mouse-ear cress) Length = 608 Score = 79.3 bits (194), Expect = 3e-14 Identities = 82/282 (29%), Positives = 129/282 (45%), Gaps = 18/282 (6%) Frame = +3 Query: 3 KGSNGTVVFEGSYDGREVAVKRL-LRSHTDIAQKEIQNL------IASDRDPNIVRLYGC 161 +GS G+V S DG AVK + L AQ+ IQ L ++ + NIVR G Sbjct: 341 RGSFGSVYEGISGDGDFFAVKEVSLLDQGSQAQECIQQLEGEIKLLSQLQHQNIVRYRGT 400 Query: 162 DQDDNFVYISLERC-HCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVV 338 +D + +YI LE SL L Q++ + V L+T R ++ Sbjct: 401 AKDGSNLYIFLELVTQGSLLKLYQRY------QLRDSVVSLYT-------------RQIL 441 Query: 339 AGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSG 518 G+ +LH G IHRD+K N+L+ G++ KL+D G++K +S + + G+ Sbjct: 442 DGLKYLHDKGFIHRDIKCANILVDANGAV--KLADFGLAK-----VSKFNDIKSCKGTPF 494 Query: 519 WQAPEQLRRASQT---RAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDL--FV 683 W APE + R D++SLGC + T G+ P+ D+ + F + Sbjct: 495 WMAPEVINRKDSDGYGSPADIWSLGCTVLEMCT-GQIPYS-----DLEPVQALFRIGRGT 548 Query: 684 VDHIPEAVHLISLL-----LQPKPDERPTAMYAINHPLFWSP 794 + +P+ + L + L L+ P+ERPTA +NHP P Sbjct: 549 LPEVPDTLSLDARLFILKCLKVNPEERPTAAELLNHPFVRRP 590
>Q7T6Y2:YR831_MIMIV Putative serine/threonine-protein kinase/receptor R831 precursor -| Mimivirus Length = 1624 Score = 79.0 bits (193), Expect = 4e-14 Identities = 73/259 (28%), Positives = 123/259 (47%), Gaps = 9/259 (3%) Frame = +3 Query: 6 GSNGTVVFEGSYDGREVAVKRLLR---SHTDIAQKEIQNLIASD-RDPNIVRLYG-CDQD 170 GS G +VF G + G +VAVK+ ++ S T + + + S+ + NIV G C + Sbjct: 1373 GSYG-IVFNGKWKGVDVAVKKFVKQKLSETQLLEFRAEMAFLSELKHSNIVTFIGACIKK 1431 Query: 171 DNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIV 350 N ++ +L D+++ + D + K LKL+ GI Sbjct: 1432 PNICIVTEYMRMGNLRDVLK-NPDIKITFANK----------------LKLLYGAAMGID 1474 Query: 351 HLHSLG--IIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQ 524 +LHS I+HRD+KP N+L+ + + K++D G + R++ED ++++ GT W Sbjct: 1475 YLHSSNPMIVHRDIKPANILVDEH--FNVKIADFGFA-RIKEDNTTMTRCGT----PCWT 1527 Query: 525 APEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGE--YYERDINIINGHFDLFVVDHIP 698 APE +R D+FS G +++ +T GK PF E + + ++I+ G + D Sbjct: 1528 APEVIRGEKYCEKADVFSFGVVMWEVLT-GKEPFAECNFMKVSLDILEGGRPIIPSDCPH 1586 Query: 699 EAVHLISLLLQPKPDERPT 755 E LI K +RPT Sbjct: 1587 EFAKLIKKCWHAKAHKRPT 1605 Score = 58.2 bits (139), Expect = 8e-08 Identities = 51/203 (25%), Positives = 91/203 (44%), Gaps = 7/203 (3%) Frame = +3 Query: 24 VFEGSYDGREVAVKRLLRSHTDIAQK----EIQNLIASDRDPNIVRLYGCDQDDNFVYIS 191 V++ + G EVAVK + H + E ++ S R PN+V + I Sbjct: 800 VYKSIWKGTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAASTKSPNMCIV 859 Query: 192 LERCHC-SLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLG 368 +E SL DL+ P +P +K+ G+ LHS G Sbjct: 860 MEFMSLGSLYDLLGNELIPE----------------IPYALKIKMAYQASKGMHFLHSSG 903 Query: 369 IIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRA 548 I+HRDLK N+L+ + + K+SD G++K ++ ++ + G+ W APE L + Sbjct: 904 IVHRDLKSLNLLL--DSKWNVKVSDFGLTK-VKSELDKKKTNDNIIGTIHWIAPEILNDS 960 Query: 549 SQTRAM--DLFSLGCLIFYCITK 611 ++ + D++S G +++ +T+ Sbjct: 961 TEVDYILADVYSFGIILWELLTR 983
>P51957:NEK4_HUMAN Serine/threonine-protein kinase Nek4 - Homo sapiens (Human)| Length = 841 Score = 79.0 bits (193), Expect = 4e-14 Identities = 78/275 (28%), Positives = 128/275 (46%), Gaps = 16/275 (5%) Frame = +3 Query: 3 KGSNGTVVF-EGSYDGREVAVKRL-LRSHTD----IAQKEIQNLIASDRDPNIVRLY-GC 161 KGS G V + DG++ +K+L LR+ + A++E Q L++ + PNIV Sbjct: 14 KGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQ-LLSQLKHPNIVTYKESW 72 Query: 162 DQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDG--LPSPQLLKLMRDV 335 + D +YI + C DL ++ L Q G LP Q+++ + Sbjct: 73 EGGDGLLYIVMG--FCEGGDLYRK---------------LKEQKGQLLPENQVVEWFVQI 115 Query: 336 VAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQE--DMSSLSHHGTGYG 509 + +LH I+HRDLK QNV +++ + K+ D+GI++ L+ DM+S T G Sbjct: 116 AMALQYLHEKHILHRDLKTQNVFLTRTNII--KVGDLGIARVLENHCDMAS-----TLIG 168 Query: 510 SSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDIN-----IINGHFD 674 + + +PE D+++LGC ++ T KH F +D+N II G Sbjct: 169 TPYYMSPELFSNKPYNYKSDVWALGCCVYEMATL-KHAFN---AKDMNSLVYRIIEGKLP 224 Query: 675 LFVVDHIPEAVHLISLLLQPKPDERPTAMYAINHP 779 D+ PE LI +L +P+ERP+ + P Sbjct: 225 AMPRDYSPELAELIRTMLSKRPEERPSVRSILRQP 259
>Q03963:E2AK2_MOUSE Interferon-induced, double-stranded RNA-activated protein kinase -| Mus musculus (Mouse) Length = 515 Score = 79.0 bits (193), Expect = 4e-14 Identities = 70/248 (28%), Positives = 124/248 (50%), Gaps = 11/248 (4%) Frame = +3 Query: 42 DGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLAD 221 DG+ A+KR+ + +T+ A+ E+Q L A NIV+ + C + + + H S++D Sbjct: 264 DGKRYAIKRV-KYNTEKAEHEVQAL-AELNHVNIVQYHSCWEG-----VDYDPEH-SMSD 315 Query: 222 LIQQHTDPSFSDVEKID---VELW----TQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHR 380 + T F +E D +E W Q + +L L +V G+ ++HS G+IHR Sbjct: 316 TSRYKTRCLFIQMEFCDKGTLEQWMRNRNQSKVDKALILDLYEQIVTGVEYIHSKGLIHR 375 Query: 381 DLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTR 560 DLKP N+ + E + K+ D G++ L+ D S + G+ + +PEQL + Sbjct: 376 DLKPGNIFLVDERHI--KIGDFGLATALENDGKSRTRR---TGTLQYMSPEQLFLKHYGK 430 Query: 561 AMDLFSLGC----LIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPEAVHLISLLL 728 +D+F+LG L+ C T+ + +++E ++ G F + D+ ++ L+ LL Sbjct: 431 EVDIFALGLILAELLHTCFTESEKI--KFFE---SLRKGDFSNDIFDNKEKS--LLKKLL 483 Query: 729 QPKPDERP 752 KP +RP Sbjct: 484 SEKPKDRP 491
>P39009:DUN1_YEAST DNA damage response protein kinase DUN1 - Saccharomyces cerevisiae| (Baker's yeast) Length = 513 Score = 79.0 bits (193), Expect = 4e-14 Identities = 84/306 (27%), Positives = 133/306 (43%), Gaps = 39/306 (12%) Frame = +3 Query: 45 GREVAVKRLLRSHTDIAQKEIQ-----NLIASDRDPNIVRLYGCDQDDNFVYISLERCHC 209 G++VAVK D +K Q N++ + PNIV L D+FV Sbjct: 223 GQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQHPNIVNLL-----DSFV--------- 268 Query: 210 SLADLIQQHTDPSFSDVEKID-----VELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGII 374 + I + + +EKID + + L + L + ++ G+ +LH II Sbjct: 269 ---EPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGLKYLHEQNII 325 Query: 375 HRDLKPQNVLIS-----------------KEGSLSAKLSDMGISKRLQEDMSSLSHHGTG 503 HRD+KP+N+L++ E + K++D G++K E + T Sbjct: 326 HRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGE----MQFTNTL 381 Query: 504 YGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYY---ERDINIINGHFD 674 G+ + APE L + T +DL+S G +++ C+ G PF + I+ + Sbjct: 382 CGTPSYVAPEVLTKKGYTSKVDLWSAGVILYVCLC-GFPPFSDQLGPPSLKEQILQAKYA 440 Query: 675 LF--VVDHIPEAV-HLISLLLQPKPDERPTAMYAINHPLF------WSPELRLLFLRDTS 827 + D I ++V HLIS LL PDER A+NHP F S L L L+ T Sbjct: 441 FYSPYWDKIDDSVLHLISNLLVLNPDERYNIDEALNHPWFNDIQQQSSVSLELQRLQITD 500 Query: 828 DRIEKT 845 ++I KT Sbjct: 501 NKIPKT 506
>Q8WMV0:GRK7_BOVIN G protein-coupled receptor kinase 7 precursor - Bos taurus (Bovine)| Length = 552 Score = 78.6 bits (192), Expect = 6e-14 Identities = 43/120 (35%), Positives = 74/120 (61%), Gaps = 1/120 (0%) Frame = +3 Query: 288 QDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQ 467 + GL +++ + G++HLHSLGI++RD+KP+NVL+ G + +LSD+G++ ++Q Sbjct: 285 EPGLDMSRVIFYSAQITCGVLHLHSLGIVYRDMKPENVLLDDLG--NCRLSDLGLAVQIQ 342 Query: 468 EDMSSLSHHGTGYGSSGWQAPEQL-RRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYER 644 + GT +G+ APE L +AS + +D F++GC I Y + G+ PF +Y E+ Sbjct: 343 DGKPITQRAGT----NGYMAPEILMEKASYSYPVDWFAMGCSI-YEMVAGRTPFRDYKEK 397
>Q91736:EPB1B_XENLA Ephrin type-B receptor 1-B - Xenopus laevis (African clawed frog)| Length = 902 Score = 78.6 bits (192), Expect = 6e-14 Identities = 60/229 (26%), Positives = 109/229 (47%), Gaps = 6/229 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +++ +++ +++ PNI+RL G V I E D Sbjct: 566 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDS 625 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 626 FLRQNDGQFTVI----------------QLVGMLRGIAAGMKYLSEMNYVHRDLAARNIL 669 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ LQ+D S ++ + G W APE +R T A D++S Sbjct: 670 VN--SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIRYRKFTSASDVWS 727 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL 722 G +++ ++ G+ P+ + +D IN I + L P A+H + L Sbjct: 728 YGIVMWEVMSYGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLML 776
>P62343:CDPK1_PLAFK Calcium-dependent protein kinase 1 - Plasmodium falciparum (isolate| K1 / Thailand) Length = 524 Score = 78.6 bits (192), Expect = 6e-14 Identities = 73/274 (26%), Positives = 128/274 (46%), Gaps = 9/274 (3%) Frame = +3 Query: 87 DIAQKEIQN---LIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSD 257 D +EI N L+ S PNI++L+ +D + Y+ E F + Sbjct: 107 DKIHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTE-----------------FYE 149 Query: 258 VEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAK 434 ++ ++ + +M+ +++GI +LH I+HRD+KP+N+L+ +K L+ K Sbjct: 150 GGELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKHSLLNIK 209 Query: 435 LSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKG 614 + D G+S +D GT Y + APE LR+ + D++S G +I Y + G Sbjct: 210 IVDFGLSSFFSKDNKLRDRLGTAY----YIAPEVLRKKYNEKC-DVWSCG-VILYILLCG 263 Query: 615 KHPFGEYYERDI--NIING--HFDLFVVDHI-PEAVHLISLLLQPKPDERPTAMYAINHP 779 PFG ++DI + G +FD +I EA LI L+L ++R TA A+N Sbjct: 264 YPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEAKELIKLMLTYDYNKRITAKEALNSK 323 Query: 780 LFWSPELRLLFLRDTSDRIEKTTETDLLNALESI 881 +++ ++ I K+ + L AL ++ Sbjct: 324 ----------WIKKYANNINKSDQKTLCGALSNM 347
>P62344:CDPK1_PLAF7 Calcium-dependent protein kinase 1 - Plasmodium falciparum (isolate| 3D7) Length = 524 Score = 78.6 bits (192), Expect = 6e-14 Identities = 73/274 (26%), Positives = 128/274 (46%), Gaps = 9/274 (3%) Frame = +3 Query: 87 DIAQKEIQN---LIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSD 257 D +EI N L+ S PNI++L+ +D + Y+ E F + Sbjct: 107 DKIHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTE-----------------FYE 149 Query: 258 VEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAK 434 ++ ++ + +M+ +++GI +LH I+HRD+KP+N+L+ +K L+ K Sbjct: 150 GGELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKHSLLNIK 209 Query: 435 LSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKG 614 + D G+S +D GT Y + APE LR+ + D++S G +I Y + G Sbjct: 210 IVDFGLSSFFSKDNKLRDRLGTAY----YIAPEVLRKKYNEKC-DVWSCG-VILYILLCG 263 Query: 615 KHPFGEYYERDI--NIING--HFDLFVVDHI-PEAVHLISLLLQPKPDERPTAMYAINHP 779 PFG ++DI + G +FD +I EA LI L+L ++R TA A+N Sbjct: 264 YPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEAKELIKLMLTYDYNKRITAKEALNSK 323 Query: 780 LFWSPELRLLFLRDTSDRIEKTTETDLLNALESI 881 +++ ++ I K+ + L AL ++ Sbjct: 324 ----------WIKKYANNINKSDQKTLCGALSNM 347
>P23561:STE11_YEAST Serine/threonine-protein kinase STE11 - Saccharomyces cerevisiae| (Baker's yeast) Length = 738 Score = 78.2 bits (191), Expect = 7e-14 Identities = 53/187 (28%), Positives = 85/187 (45%) Frame = +3 Query: 75 RSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFS 254 R D Q E+ NL+ NIV YG Q+ + I LE + + P Sbjct: 516 RKMVDALQHEM-NLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYGPFEE 574 Query: 255 DVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAK 434 + + R ++ G+ +LH IIHRD+K N+LI +G + K Sbjct: 575 SL-----------------ITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCV--K 615 Query: 435 LSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKG 614 ++D GISK+L + + GS W +PE +++ + T D++S GC++ T G Sbjct: 616 ITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFT-G 674 Query: 615 KHPFGEY 635 KHPF ++ Sbjct: 675 KHPFPDF 681
>Q8C1R0:TSSK5_MOUSE Testis-specific serine/threonine-protein kinase 5 - Mus musculus| (Mouse) Length = 372 Score = 77.8 bits (190), Expect = 9e-14 Identities = 72/219 (32%), Positives = 109/219 (49%), Gaps = 2/219 (0%) Frame = +3 Query: 99 KEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVE 278 +EI +L A+ + NIV+LY Q+ Y+ LE + DL++ S + Sbjct: 90 REILSLNATYKHMNIVQLYETYQNSQRSYLVLELA--ARGDLLEHINAVS---------D 138 Query: 279 LWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISK 458 L GL + +L +V+ + H H++GI+HRDLK +N+L+ +G + KL+D G + Sbjct: 139 LRCCPGLEEEEARRLFWQLVSAVAHCHNVGIVHRDLKCENILLDDQGFI--KLTDFGFAN 196 Query: 459 RLQEDMSSLSHHGTGYGSSGWQAPEQL-RRASQTRAMDLFSLGCLIFYCITKGKHPFGEY 635 + S LS T GS + APE L + DL+SLG +I + + GK PF E+ Sbjct: 197 WVGLKNSLLS---TFCGSVAYTAPEILMSKKYNGEQADLWSLG-IILHAMVSGKLPFKEH 252 Query: 636 Y-ERDINIINGHFDLFVVDHIPEAVHLISLLLQPKPDER 749 R +N+I +F PE LI LLQ P ER Sbjct: 253 QPHRMLNLIR-RGPIFRPGLSPECRDLIRGLLQLHPCER 290
>Q8WP15:GRK7_PIG G protein-coupled receptor kinase 7 precursor - Sus scrofa (Pig)| Length = 553 Score = 77.8 bits (190), Expect = 9e-14 Identities = 44/118 (37%), Positives = 73/118 (61%), Gaps = 1/118 (0%) Frame = +3 Query: 294 GLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQED 473 GL +++ + G++HLHSLGI++RDLKP+NVL+ G + +LSD+G++ ++Q+ Sbjct: 287 GLDMNRVIFYSAQMTCGVLHLHSLGIVYRDLKPENVLLDDLG--NCRLSDLGLAVQIQDG 344 Query: 474 MSSLSHHGTGYGSSGWQAPEQL-RRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYER 644 GT +G+ APE L +AS + +D F++GC I Y + G+ PF +Y E+ Sbjct: 345 KPVTQRAGT----NGYMAPEILMEKASYSYPVDWFAMGCSI-YEMVAGRTPFKDYKEK 397
>Q8IYT8:ULK2_HUMAN Serine/threonine-protein kinase ULK2 - Homo sapiens (Human)| Length = 1036 Score = 77.4 bits (189), Expect = 1e-13 Identities = 67/227 (29%), Positives = 110/227 (48%), Gaps = 15/227 (6%) Frame = +3 Query: 21 VVFEGSYDGR---EVAVKRLLRSHTDIAQ----KEIQNLIASDRDPNIVRLYGCDQDDNF 179 VVF G + + EVA+K + + + +Q KEI+ ++ + NIV LY + N Sbjct: 22 VVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIK-ILKELQHENIVALYDVQELPNS 80 Query: 180 VYISLERCHCS-LADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHL 356 V++ +E C+ LAD +Q + L + + + A + L Sbjct: 81 VFLVMEYCNGGDLADYLQ------------------AKGTLSEDTIRVFLHQIAAAMRIL 122 Query: 357 HSLGIIHRDLKPQNVLIS----KEGSLSA---KLSDMGISKRLQEDMSSLSHHGTGYGSS 515 HS GIIHRDLKPQN+L+S ++ S+S K++D G ++ L +M + T GS Sbjct: 123 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMA----ATLCGSP 178 Query: 516 GWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINI 656 + APE + DL+S+G +I+ C+ GK PF +D+ + Sbjct: 179 MYMAPEVIMSQHYDAKADLWSIGTVIYQCLV-GKPPFQANSPQDLRM 224
>P51955:NEK2_HUMAN Serine/threonine-protein kinase Nek2 - Homo sapiens (Human)| Length = 445 Score = 77.4 bits (189), Expect = 1e-13 Identities = 71/261 (27%), Positives = 120/261 (45%), Gaps = 14/261 (5%) Frame = +3 Query: 42 DGREVAVKRLLRSHTDIAQKEIQ----NLIASDRDPNIVRLYG--CDQDDNFVYISLERC 203 DG+ + K L A+K++ NL+ + PNIVR Y D+ + +YI +E C Sbjct: 30 DGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYC 89 Query: 204 HCS-LADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLG---- 368 LA +I + T + + +D E +L++M + + H Sbjct: 90 EGGDLASVITKGT----KERQYLDEEF----------VLRVMTQLTLALKECHRRSDGGH 135 Query: 369 -IIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRR 545 ++HRDLKP NV + +G + KL D G+++ L D S T G+ + +PEQ+ R Sbjct: 136 TVLHRDLKPANVFL--DGKQNVKLGDFGLARILNHDTSFAK---TFVGTPYYMSPEQMNR 190 Query: 546 ASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NIINGHFDLFVVDHIPEAVHLIS 719 S D++SLGCL+ Y + PF + ++++ I G F + E +I+ Sbjct: 191 MSYNEKSDIWSLGCLL-YELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIIT 249 Query: 720 LLLQPKPDERPTAMYAINHPL 782 +L K RP+ + +PL Sbjct: 250 RMLNLKDYHRPSVEEILENPL 270
>O14328:KSP1_SCHPO Serine/threonine-protein kinase ksp1 - Schizosaccharomyces pombe| (Fission yeast) Length = 474 Score = 77.4 bits (189), Expect = 1e-13 Identities = 68/230 (29%), Positives = 112/230 (48%), Gaps = 15/230 (6%) Frame = +3 Query: 3 KGSNGTVVFEGSY------DGREVAVKRLLR-SHTDIAQKEIQNLIASDRDPNIVRLYGC 161 KGS GTVV + A+K + + ++T + + I ++ R NI+ Sbjct: 17 KGSYGTVVLAHRLFRTPRCKDLKYAIKCIKKPAYTFLQEVNILRQLSRSRHRNIIHFVES 76 Query: 162 DQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLK-LMRDVV 338 +D+ + Y+ LE +C L DL + + F + + P+++K + ++ Sbjct: 77 FEDNVYYYVVLE--YCPLGDLYECILNNDFPNAKN------------QPEMIKNIFLQII 122 Query: 339 AGIVHLHSLGIIHRDLKPQNVL--ISKEGS-LSAKLSDMGISKRLQEDMSSLSHHGTGYG 509 G+ HLHS GI HRDLKP+N L +S++GS L K+SD G++ R D S + G G Sbjct: 123 DGVAHLHSHGIYHRDLKPENFLLSLSEDGSELVVKISDFGLACR---DKIS---YDFGTG 176 Query: 510 SSGWQAPEQLRRAS----QTRAMDLFSLGCLIFYCITKGKHPFGEYYERD 647 S + APEQ RA D+++LG + I ++PF +E+D Sbjct: 177 SDRYMAPEQFEEVDGAGYSPRAADIWALGICLLNLIF-ARNPFTYPHEKD 225
>Q00168:KCC2A_DROME Calcium/calmodulin-dependent protein kinase type II alpha chain -| Drosophila melanogaster (Fruit fly) Length = 530 Score = 77.4 bits (189), Expect = 1e-13 Identities = 60/224 (26%), Positives = 112/224 (50%), Gaps = 9/224 (4%) Frame = +3 Query: 135 PNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQL 314 PNIVRL+ Q++N+ Y+ + DL+ F D+ + E +++ Sbjct: 71 PNIVRLHDSIQEENYHYL--------VFDLVTG--GELFEDI--VAREFYSE-----ADA 113 Query: 315 LKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSH 491 ++ ++ + H H G++HRDLKP+N+L+ SK + KL+D G++ +Q D + Sbjct: 114 SHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFG 173 Query: 492 HGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHF 671 G+ G+ +PE L++ +++D+++ G +I Y + G PF ++ D + + Sbjct: 174 FA---GTPGYLSPEVLKKEPYGKSVDIWACG-VILYILLVGYPPF---WDEDQHRLYSQI 226 Query: 672 DLFVVDH--------IPEAVHLISLLLQPKPDERPTAMYAINHP 779 D+ PEA +LI+ +L P++R TA A+ HP Sbjct: 227 KAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHP 270
>Q96NX5:KCC1G_HUMAN Calcium/calmodulin-dependent protein kinase type 1G - Homo sapiens| (Human) Length = 476 Score = 77.4 bits (189), Expect = 1e-13 Identities = 53/159 (33%), Positives = 88/159 (55%), Gaps = 6/159 (3%) Frame = +3 Query: 321 LMRDVVAGIVHLHSLGIIHRDLKPQNVL-ISKEGSLSAKLSDMGISKRLQEDMSSLSHHG 497 +++ V++ + +LH GI+HRDLKP+N+L ++ E + ++D G+SK Q + S Sbjct: 123 VIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMS----- 177 Query: 498 TGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NIINGHF 671 T G+ G+ APE L + ++A+D +S+G +I Y + G PF E E + I G++ Sbjct: 178 TACGTPGYVAPEVLAQKPYSKAVDCWSIG-VITYILLCGYPPFYEETESKLFEKIKEGYY 236 Query: 672 DL---FVVDHIPEAVHLISLLLQPKPDERPTAMYAINHP 779 + F D A I LL+ P+ER T A++HP Sbjct: 237 EFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHP 275
>P54756:EPHA5_HUMAN Ephrin type-A receptor 5 precursor - Homo sapiens (Human)| Length = 1037 Score = 77.4 bits (189), Expect = 1e-13 Identities = 86/354 (24%), Positives = 153/354 (43%), Gaps = 15/354 (4%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PNI+ L G V I E D Sbjct: 704 VAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDT 763 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L +G +HRDL +N+L Sbjct: 764 FLKKNDGQFTVI----------------QLVGMLRGISAGMKYLSDMGYVHRDLAARNIL 807 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 I+ +L K+SD G+S+ L++D + G W APE + T A D++S G Sbjct: 808 IN--SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYG 865 Query: 585 CLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERPTA 758 +++ ++ G+ P+ E +D I + + L P A++ + L Q + + RP Sbjct: 866 IVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKF 925 Query: 759 MYAIN--HPLFWSPELRLLFLRDTSDRIEKTTETDLLNALESIGHQAFG--GKWREKLDD 926 +N L +P L L + S R+ ++LL +G A+ G+W E + Sbjct: 926 DEIVNMLDKLIRNPS-SLKTLVNASCRV-----SNLLAEHSPLGSGAYRSVGEWLEAIKM 979 Query: 927 GLVADVGRYRKYNF------ESTRDLLRLIRNKSGHYRELPTDLKESLGSLPEG 1070 G ++ Y+ + DL RL GH +++ L+E L G Sbjct: 980 GRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNG 1033
>P70032:PLK1_XENLA Serine/threonine-protein kinase PLK1 - Xenopus laevis (African| clawed frog) Length = 598 Score = 77.0 bits (188), Expect = 2e-13 Identities = 68/256 (26%), Positives = 118/256 (46%), Gaps = 5/256 (1%) Frame = +3 Query: 39 YDGREVAVKRLLRSHTDIAQKEIQNL-IASDRD---PNIVRLYGCDQDDNFVYISLERCH 206 + G+ V LL+ H QK+ + IA R ++V +G +D++FVY+ LE C Sbjct: 70 FAGKIVPKTMLLKPH----QKDKMTMEIAIQRSLDHRHVVGFHGFFEDNDFVYVVLELCR 125 Query: 207 CSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDL 386 L++ H + + P+ ++ ++G +LHS +IHRDL Sbjct: 126 --RRSLLELHK---------------RRKAVTEPEARYYLKQTISGCQYLHSNRVIHRDL 168 Query: 387 KPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAM 566 K N+ ++ E + K+ D G++ +++ D T G+ + APE L + + + Sbjct: 169 KLGNLFLNDE--MEVKIGDFGLATKVEYDG---ERKKTLCGTPNYIAPEVLGKKGHSFEV 223 Query: 567 DLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHI-PEAVHLISLLLQPKPD 743 D++S+GC I Y + GK PF ++ + + + HI P A LI +L+ P Sbjct: 224 DIWSIGC-IMYTLLVGKPPFETSCLKETYMRIKKNEYSIPKHINPVAAALIQKMLRSDPT 282 Query: 744 ERPTAMYAINHPLFWS 791 RPT +N F S Sbjct: 283 SRPTIDDLLNDEFFTS 298
>Q7TNJ7:KCC1G_RAT Calcium/calmodulin-dependent protein kinase type 1G - Rattus| norvegicus (Rat) Length = 476 Score = 77.0 bits (188), Expect = 2e-13 Identities = 53/159 (33%), Positives = 87/159 (54%), Gaps = 6/159 (3%) Frame = +3 Query: 321 LMRDVVAGIVHLHSLGIIHRDLKPQNVL-ISKEGSLSAKLSDMGISKRLQEDMSSLSHHG 497 +++ V++ + +LH GI+HRDLKP+N+L ++ E + ++D G+SK Q + S Sbjct: 123 VIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGVMS----- 177 Query: 498 TGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NIINGHF 671 T G+ G+ APE L + ++A+D +S+G +I Y + G PF E E + I G++ Sbjct: 178 TACGTPGYVAPEVLAQKPYSKAVDCWSIG-VITYILLCGYPPFYEETESKLFEKIKEGYY 236 Query: 672 DL---FVVDHIPEAVHLISLLLQPKPDERPTAMYAINHP 779 + F D A I LL+ P+ER T A+ HP Sbjct: 237 EFESPFWDDISESAKDFICHLLEKDPNERYTCEKALRHP 275
>Q91VB2:KCC1G_MOUSE Calcium/calmodulin-dependent protein kinase type 1G - Mus musculus| (Mouse) Length = 477 Score = 77.0 bits (188), Expect = 2e-13 Identities = 53/159 (33%), Positives = 87/159 (54%), Gaps = 6/159 (3%) Frame = +3 Query: 321 LMRDVVAGIVHLHSLGIIHRDLKPQNVL-ISKEGSLSAKLSDMGISKRLQEDMSSLSHHG 497 +++ V++ + +LH GI+HRDLKP+N+L ++ E + ++D G+SK Q + S Sbjct: 123 VIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGVMS----- 177 Query: 498 TGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NIINGHF 671 T G+ G+ APE L + ++A+D +S+G +I Y + G PF E E + I G++ Sbjct: 178 TACGTPGYVAPEVLAQKPYSKAVDCWSIG-VITYILLCGYPPFYEETESKLFEKIKEGYY 236 Query: 672 DL---FVVDHIPEAVHLISLLLQPKPDERPTAMYAINHP 779 + F D A I LL+ P+ER T A+ HP Sbjct: 237 EFESPFWDDISESAKDFICHLLEKDPNERYTCEKALRHP 275
>Q7RAH3:CDPK1_PLAYO Calcium-dependent protein kinase 1 - Plasmodium yoelii yoelii| Length = 535 Score = 77.0 bits (188), Expect = 2e-13 Identities = 73/279 (26%), Positives = 131/279 (46%), Gaps = 6/279 (2%) Frame = +3 Query: 63 KRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTD 242 K + + H +I EI L + D PNI++L+ +D + Y+ E Sbjct: 103 KNIEKFHEEI-YNEISLLKSLDH-PNIIKLFDVFEDKKYFYLVTE--------------- 145 Query: 243 PSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGS 422 F + ++ ++ + +M+ +++GI +LH I+HRD+KP+N+L+ + S Sbjct: 146 --FYEGGELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNS 203 Query: 423 -LSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFY 599 L+ K+ D G+S +D GT Y + APE L++ + D++S G +I Y Sbjct: 204 LLNIKIVDFGLSSFFSKDYKLRDRLGTAY----YIAPEVLKKKYNEKC-DVWSCG-VIMY 257 Query: 600 CITKGKHPFGEYYERDI--NIING--HFDLFVVDHI-PEAVHLISLLLQPKPDERPTAMY 764 + G PFG ++DI + G +FD +I EA LI L+L ++R TA Sbjct: 258 ILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCTAEE 317 Query: 765 AINHPLFWSPELRLLFLRDTSDRIEKTTETDLLNALESI 881 A+N +++ ++ I K+ + L AL ++ Sbjct: 318 ALNS----------RWIKKYANNINKSDQKTLCGALSNM 346
>Q9N2L7:PLK2_CAEEL Serine/threonine-protein kinase plk-2 - Caenorhabditis elegans| Length = 632 Score = 76.6 bits (187), Expect = 2e-13 Identities = 59/208 (28%), Positives = 95/208 (45%), Gaps = 1/208 (0%) Frame = +3 Query: 138 NIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLL 317 N+V+LY +D + VYI+LE C L++ H + + P+ Sbjct: 95 NVVKLYHFFEDKSNVYITLELC--PRRSLMELHK---------------RRKAVTEPEAR 137 Query: 318 KLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHG 497 +V G+++LH+L I+HRDLK N+ ++ E L K+ D G++ D Sbjct: 138 YFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDE--LQVKIGDFGLATTCDND----ERKK 191 Query: 498 TGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-GEYYERDINIINGHFD 674 T G+ + APE L + + +DL+++GC I Y + G PF + E + I + Sbjct: 192 TLCGTPNYIAPEVLNKIGHSFEVDLWAIGC-ILYILLFGHPPFESKSLEETYSRIKNNNY 250 Query: 675 LFVVDHIPEAVHLISLLLQPKPDERPTA 758 + A LI +LL P P RP A Sbjct: 251 VIPTSASAAASQLIRVLLDPVPSRRPNA 278
>P62205:PLK1_XENTR Serine/threonine-protein kinase PLK1 - Xenopus tropicalis (Western| clawed frog) (Silurana tropicalis) Length = 598 Score = 76.6 bits (187), Expect = 2e-13 Identities = 68/254 (26%), Positives = 117/254 (46%), Gaps = 5/254 (1%) Frame = +3 Query: 39 YDGREVAVKRLLRSHTDIAQKEIQNL-IASDRD---PNIVRLYGCDQDDNFVYISLERCH 206 + G+ V LL+ H QK+ + IA R ++V +G +D++FVY+ LE C Sbjct: 70 FAGKIVPKTMLLKPH----QKDKMTMEIAIQRSLDHRHVVGFHGFFEDNDFVYVVLELCR 125 Query: 207 CSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDL 386 L++ H + + P+ ++ + G +LHS +IHRDL Sbjct: 126 --RRSLLELHK---------------RRKAVTEPEARYYLKQTILGCQYLHSNRVIHRDL 168 Query: 387 KPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAM 566 K N+ ++ E + K+ D G++ +++ D T G+ + APE L + + + Sbjct: 169 KLGNLFLNDE--MEVKIGDFGLATKVEYDG---ERKKTLCGTPNYIAPEVLGKKGHSFEV 223 Query: 567 DLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHI-PEAVHLISLLLQPKPD 743 D++S+GC I Y + GK PF ++ + + V HI P A LI +L+ +P Sbjct: 224 DIWSIGC-IMYTLLVGKPPFETSCLKETYMRIKKNEYSVPKHINPMATALIQKMLRSEPT 282 Query: 744 ERPTAMYAINHPLF 785 RPT +N F Sbjct: 283 SRPTIDDLLNDEFF 296
>Q9Z2G7:GRK7_SPETR G protein-coupled receptor kinase 7 precursor - Spermophilus| tridecemlineatus (Thirteen-lined ground squirrel) Length = 548 Score = 76.6 bits (187), Expect = 2e-13 Identities = 43/118 (36%), Positives = 72/118 (61%), Gaps = 1/118 (0%) Frame = +3 Query: 294 GLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQED 473 GL +++ + G++HLH LGI++RDLKP+NVL+ G + +LSD+G++ +Q+D Sbjct: 282 GLAMSRVIFYTAQMTCGVLHLHGLGIVYRDLKPENVLLDDLG--NCRLSDLGLAVEVQDD 339 Query: 474 MSSLSHHGTGYGSSGWQAPEQLR-RASQTRAMDLFSLGCLIFYCITKGKHPFGEYYER 644 GT +G+ APE L +AS + +D F++GC I Y + G+ PF ++ E+ Sbjct: 340 KPITQRAGT----NGYMAPEILMDKASYSYPVDWFAMGCSI-YEMVAGRTPFKDFKEK 392
>P09759:EPHB1_RAT Ephrin type-B receptor 1 precursor - Rattus norvegicus (Rat)| Length = 984 Score = 76.6 bits (187), Expect = 2e-13 Identities = 81/346 (23%), Positives = 149/346 (43%), Gaps = 21/346 (6%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +++ +++ +++ PNI+RL G V I E D Sbjct: 648 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDS 707 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 708 FLRQNDGQFTVI----------------QLVGMLRGIAAGMKYLSEMNYVHRDLAARNIL 751 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ LQ+D S ++ + G W APE + T A D++S Sbjct: 752 VN--SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWS 809 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERP 752 G +++ ++ G+ P+ + +D IN I + L P A+H + L Q + RP Sbjct: 810 YGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRP 869 Query: 753 TAMYAIN--HPLFWSP------------ELRLLFLRDTSDRIEKTTETDLLNALESIGHQ 890 +N + +P + L R D TT D L+A++ + ++ Sbjct: 870 RFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYR 929 Query: 891 AFGGKWREKLDDGLVADVGRYRKYNFESTRDLLRLIRNKSGHYREL 1028 D L A + ++ DLLR+ +GH +++ Sbjct: 930 ----------DSFLTAGFTSLQLVTQMTSEDLLRIGVTLAGHQKKI 965
>Q8CBF3:EPHB1_MOUSE Ephrin type-B receptor 1 precursor - Mus musculus (Mouse)| Length = 984 Score = 76.6 bits (187), Expect = 2e-13 Identities = 81/346 (23%), Positives = 149/346 (43%), Gaps = 21/346 (6%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +++ +++ +++ PNI+RL G V I E D Sbjct: 648 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDS 707 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 708 FLRQNDGQFTVI----------------QLVGMLRGIAAGMKYLSEMNYVHRDLAARNIL 751 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ LQ+D S ++ + G W APE + T A D++S Sbjct: 752 VN--SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWS 809 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERP 752 G +++ ++ G+ P+ + +D IN I + L P A+H + L Q + RP Sbjct: 810 YGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRP 869 Query: 753 TAMYAIN--HPLFWSP------------ELRLLFLRDTSDRIEKTTETDLLNALESIGHQ 890 +N + +P + L R D TT D L+A++ + ++ Sbjct: 870 RFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYR 929 Query: 891 AFGGKWREKLDDGLVADVGRYRKYNFESTRDLLRLIRNKSGHYREL 1028 D L A + ++ DLLR+ +GH +++ Sbjct: 930 ----------DSFLTAGFTSLQLVTQMTSEDLLRIGVTLAGHQKKI 965
>Q56UN5:YSK4_HUMAN SPS1/STE20-related protein kinase YSK4 - Homo sapiens (Human)| Length = 1328 Score = 76.3 bits (186), Expect = 3e-13 Identities = 77/278 (27%), Positives = 118/278 (42%), Gaps = 20/278 (7%) Frame = +3 Query: 3 KGSNGTVVFEGSYDGREVAVKRLL--RSHTDIAQKEIQ------NLIASDRDPNIVRLYG 158 KG+ GTV + G+ +AVK++ S+ A+KE + +L+ + + NIV G Sbjct: 1069 KGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLG 1128 Query: 159 CDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVV 338 +N V I +E I P LP K + ++ Sbjct: 1129 TCLQENTVSIFMEFVPGGSISSIINRFGP-----------------LPEMVFCKYTKQIL 1171 Query: 339 AGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRL--------QEDMSSLSHH 494 G+ +LH ++HRD+K NV++ G + KL D G ++RL DM S H Sbjct: 1172 QGVAYLHENCVVHRDIKGNNVMLMPTGII--KLIDFGCARRLAWAGLNGTHSDMLK-SMH 1228 Query: 495 GTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYE-RDINIINGHF 671 GT Y W APE + + R D++S+GC +F T GK P + I H Sbjct: 1229 GTPY----WMAPEVINESGYGRKSDIWSIGCTVFEMAT-GKPPLASMDRMAAMFYIGAHR 1283 Query: 672 DLF--VVDHIPE-AVHLISLLLQPKPDERPTAMYAINH 776 L + DH E A + + L ERP+A+ + H Sbjct: 1284 GLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKH 1321
>Q07832:PLK1_MOUSE Serine/threonine-protein kinase PLK1 - Mus musculus (Mouse)| Length = 603 Score = 76.3 bits (186), Expect = 3e-13 Identities = 64/252 (25%), Positives = 112/252 (44%), Gaps = 1/252 (0%) Frame = +3 Query: 39 YDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLA 218 + G+ V LL+ H ++ S ++V + +D +FV++ LE C Sbjct: 79 FAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQHVVGFHDFFEDSDFVFVVLELCR--RR 136 Query: 219 DLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQN 398 L++ H + L P+ +R +V G +LH +IHRDLK N Sbjct: 137 SLLELHK---------------RRKALTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGN 181 Query: 399 VLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFS 578 + ++++ L K+ D G++ +++ + T G+ + APE L + + +D++S Sbjct: 182 LFLNED--LEVKIGDFGLATKVEYEG---ERKKTLCGTPNYIAPEVLSKKGHSFEVDVWS 236 Query: 579 LGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHI-PEAVHLISLLLQPKPDERPT 755 +GC I Y + GK PF ++ + + + HI P A LI +LQ P RPT Sbjct: 237 IGC-IMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPT 295 Query: 756 AMYAINHPLFWS 791 +N F S Sbjct: 296 IHELLNDEFFTS 307
>Q9Y6R4:M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 - Homo sapiens| (Human) Length = 1607 Score = 76.3 bits (186), Expect = 3e-13 Identities = 61/224 (27%), Positives = 103/224 (45%), Gaps = 8/224 (3%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PN+VR +G + +YI +E C + + +V ++ GL Sbjct: 1397 KHPNLVRYFGVELHREEMYIFMEYCD-----------EGTLEEVSRL--------GLQEH 1437 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSL- 485 + + + I LH GI+HRD+K N+ ++ G + KL D G S +L+ + ++ Sbjct: 1438 VIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLI--KLGDFGCSVKLKNNAQTMP 1495 Query: 486 SHHGTGYGSSGWQAPEQLRRA---SQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINI 656 + G++ + APE + RA RA D++SLGC++ +T GK P+ E YE + I Sbjct: 1496 GEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVT-GKRPWHE-YEHNFQI 1553 Query: 657 I----NGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMYAINH 776 + GH PE +S L+ P R TA ++H Sbjct: 1554 MYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDH 1597
>Q5XIS9:KPCD2_RAT Serine/threonine-protein kinase D2 - Rattus norvegicus (Rat)| Length = 875 Score = 76.3 bits (186), Expect = 3e-13 Identities = 76/264 (28%), Positives = 126/264 (47%), Gaps = 11/264 (4%) Frame = +3 Query: 21 VVFEGSY--DGREVAVKRLLRSHTDIAQK-EIQNLIA---SDRDPNIVRLYGCDQDDNFV 182 VV+ G + GR+VAVK + + Q+ +++N +A S R P IV L + V Sbjct: 565 VVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKV 624 Query: 183 YISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLK-LMRDVVAGIVHLH 359 ++ +E+ H + ++I L ++ G +L K L+ ++ + HLH Sbjct: 625 FVVMEKLHGDMLEMI-----------------LSSEKGRLPERLTKFLITQILVALRHLH 667 Query: 360 SLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQ 536 I+H DLKP+NVL+ S + KL D G ++ + E S + G+ + APE Sbjct: 668 FKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK----SFRRSVVGTPAYLAPEV 723 Query: 537 LRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHF--DLFVVDHIPE-AV 707 L R++D++S+G +I Y G PF E + + I N F HI A+ Sbjct: 724 LLNQGYNRSLDMWSVG-VIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISSGAI 782 Query: 708 HLISLLLQPKPDERPTAMYAINHP 779 LI+ LLQ K +R + +++HP Sbjct: 783 DLINNLLQVKMRKRYSVDKSLSHP 806
>Q8BZ03:KPCD2_MOUSE Serine/threonine-protein kinase D2 - Mus musculus (Mouse)| Length = 875 Score = 76.3 bits (186), Expect = 3e-13 Identities = 76/264 (28%), Positives = 126/264 (47%), Gaps = 11/264 (4%) Frame = +3 Query: 21 VVFEGSY--DGREVAVKRLLRSHTDIAQK-EIQNLIA---SDRDPNIVRLYGCDQDDNFV 182 VV+ G + GR+VAVK + + Q+ +++N +A S R P IV L + V Sbjct: 565 VVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKV 624 Query: 183 YISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLK-LMRDVVAGIVHLH 359 ++ +E+ H + ++I L ++ G +L K L+ ++ + HLH Sbjct: 625 FVVMEKLHGDMLEMI-----------------LSSEKGRLPERLTKFLITQILVALRHLH 667 Query: 360 SLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQ 536 I+H DLKP+NVL+ S + KL D G ++ + E S + G+ + APE Sbjct: 668 FKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK----SFRRSVVGTPAYLAPEV 723 Query: 537 LRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHF--DLFVVDHIPE-AV 707 L R++D++S+G +I Y G PF E + + I N F HI A+ Sbjct: 724 LLNQGYNRSLDMWSVG-VIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISSGAI 782 Query: 708 HLISLLLQPKPDERPTAMYAINHP 779 LI+ LLQ K +R + +++HP Sbjct: 783 DLINNLLQVKMRKRYSVDKSLSHP 806
>Q07497:EPHB5_CHICK Ephrin type-B receptor 5 precursor - Gallus gallus (Chicken)| Length = 1002 Score = 76.3 bits (186), Expect = 3e-13 Identities = 59/230 (25%), Positives = 110/230 (47%), Gaps = 7/230 (3%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +TD ++E +++ PN++ L G V I E D Sbjct: 666 VAIKTLKSGYTDEQRREFLSEASIMGQFEHPNVIHLEGVVTKSRPVMIVTEFMENGSLDS 725 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + + FS + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 726 FLRQKEGQFSVL----------------QLVGMLRGIAAGMRYLSDMNYVHRDLAARNIL 769 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSS---GWQAPEQLRRASQTRAMDLF 575 ++ +L K+SD G+S+ L++D S+ ++ G G W APE ++ T + D++ Sbjct: 770 VN--SNLVCKVSDFGLSRFLEDDASNPTYTG-ALGCKIPIRWTAPEAVQYRKFTSSSDVW 826 Query: 576 SLGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL 722 S G +++ ++ G+ P+ + +D IN I+ + L P +HL+ L Sbjct: 827 SYGIVMWEVMSYGERPYWDMSNQDVINAIDQDYRLPPPPDCPTVLHLLML 876
>P54762:EPHB1_HUMAN Ephrin type-B receptor 1 precursor - Homo sapiens (Human)| Length = 984 Score = 76.3 bits (186), Expect = 3e-13 Identities = 81/346 (23%), Positives = 149/346 (43%), Gaps = 21/346 (6%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +++ +++ +++ PNI+RL G V I E D Sbjct: 648 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDS 707 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 708 FLRQNDGQFTVI----------------QLVGMLRGIAAGMKYLAEMNYVHRDLAARNIL 751 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ LQ+D S ++ + G W APE + T A D++S Sbjct: 752 VN--SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWS 809 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERP 752 G +++ ++ G+ P+ + +D IN I + L P A+H + L Q + RP Sbjct: 810 YGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRP 869 Query: 753 TAMYAIN--HPLFWSP------------ELRLLFLRDTSDRIEKTTETDLLNALESIGHQ 890 +N + +P + L R D TT D L+A++ + ++ Sbjct: 870 RFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYR 929 Query: 891 AFGGKWREKLDDGLVADVGRYRKYNFESTRDLLRLIRNKSGHYREL 1028 D L A + ++ DLLR+ +GH +++ Sbjct: 930 ----------DSFLTAGFTSLQLVTQMTSEDLLRIGITLAGHQKKI 965
>Q8BWQ5:DCLK3_MOUSE Serine/threonine-protein kinase DCLK3 - Mus musculus (Mouse)| Length = 619 Score = 76.3 bits (186), Expect = 3e-13 Identities = 71/249 (28%), Positives = 120/249 (48%), Gaps = 10/249 (4%) Frame = +3 Query: 63 KRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTD 242 K L+ DI EI +I S PNIV+L+ + + +Y+ +E Q D Sbjct: 376 KSQLKGKEDIVDSEIL-IIQSLSHPNIVKLHEVYETEAEIYLIMEYV---------QGGD 425 Query: 243 PSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI--SKE 416 + VE + P P+ ++ D+ +VH+H I+HRD+KP+N+L+ +++ Sbjct: 426 LFDAIVENVK--------FPEPEAAVMITDLCKALVHMHDKNIVHRDVKPENLLVQRNED 477 Query: 417 GSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIF 596 S++ KL+D G++K + + ++ G+ + APE L +D+++ G +I Sbjct: 478 KSITLKLADFGLAKYVVRPIFTVC------GTPTYVAPEILSEKGYGLEVDMWAAG-VIL 530 Query: 597 YCITKGKHPFGEYYERD----INIIN-GHFDLF--VVDHIPEAV-HLISLLLQPKPDERP 752 Y + G PF ERD NII G F+ D+I +A L+ LL+ P +R Sbjct: 531 YILLCGFPPF-RSPERDQDELFNIIQVGQFEFLSPYWDNISDAAKDLVRNLLEVDPKKRY 589 Query: 753 TAMYAINHP 779 TA + HP Sbjct: 590 TAEQVLQHP 598
>P22216:RAD53_YEAST Serine/threonine-protein kinase RAD53 - Saccharomyces cerevisiae| (Baker's yeast) Length = 821 Score = 75.9 bits (185), Expect = 4e-13 Identities = 72/271 (26%), Positives = 119/271 (43%), Gaps = 28/271 (10%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCS-LADLI 227 ++ KR + + D +E++ ++ P IVRL G +D Y+ +E L D + Sbjct: 227 KIISKRKVIGNMDGVTRELE-VLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFV 285 Query: 228 QQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI 407 H + ++ R ++ I ++HS+GI HRDLKP N+LI Sbjct: 286 AAH------------------GAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILI 327 Query: 408 SKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLR-------------RA 548 ++ + K++D G++K +Q + S + T G+ + APE +R R Sbjct: 328 EQDDPVLVKITDFGLAK-VQGNGSFMK---TFCGTLAYVAPEVIRGKDTSVSPDEYEERN 383 Query: 549 SQTRAMDLFSLGCLIFYCITKGKHPF--------------GEYYERDINIINGHFDLFVV 686 + +D++S+GCL+ Y I G PF G Y+E + D + Sbjct: 384 EYSSLVDMWSMGCLV-YVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLK------DFRIS 436 Query: 687 DHIPEAVHLISLLLQPKPDERPTAMYAINHP 779 + EA I LLQ P+ R TA A+NHP Sbjct: 437 E---EARDFIDSLLQVDPNNRSTAAKALNHP 464
>P34331:PLK1_CAEEL Serine/threonine-protein kinase plk-1 - Caenorhabditis elegans| Length = 649 Score = 75.9 bits (185), Expect = 4e-13 Identities = 61/212 (28%), Positives = 103/212 (48%), Gaps = 5/212 (2%) Frame = +3 Query: 138 NIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLL 317 NIV+L+ +D+ VYI+LE C + L++ H + + P+ Sbjct: 98 NIVKLFNFFEDNLNVYITLELC--ARRSLMELHK---------------RRKAVTEPEAR 140 Query: 318 KLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHG 497 +V G+++LH L IIHRD+K N+ ++ + L K+ D G++ + D Sbjct: 141 YFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDD--LVVKIGDFGLATTVNGD----ERKK 194 Query: 498 TGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-----GEYYERDINIIN 662 T G+ + APE L +A + +D++++GC I Y + G+ PF E Y R I + Sbjct: 195 TLCGTPNYIAPEVLNKAGHSFEVDIWAVGC-ILYILLFGQPPFESKSLEETYSR---IRH 250 Query: 663 GHFDLFVVDHIPEAVHLISLLLQPKPDERPTA 758 ++ + + P A LI +L P+P RPTA Sbjct: 251 NNYTIPSIATQP-AASLIRKMLDPEPTRRPTA 281
>Q8FUI5:PKN1_COREF Probable serine/threonine protein kinase CE0033 - Corynebacterium| efficiens Length = 660 Score = 75.9 bits (185), Expect = 4e-13 Identities = 63/219 (28%), Positives = 104/219 (47%), Gaps = 20/219 (9%) Frame = +3 Query: 45 GREVAVKRLLRSHTDIAQ---------KEIQNLIASDRDPNIVRLYGCDQDD----NFVY 185 GREVAVK L TD+A+ +E QN P+IV ++ + D + Y Sbjct: 32 GREVAVKML---RTDLAKDVNFRERFRREAQNA-GKLSHPSIVAVFDTGEVDRDGISVPY 87 Query: 186 ISLERCHC-SLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP-QLLKLMRDVVAGIVHLH 359 I +ER H L D++++ DG SP Q +M V + H Sbjct: 88 IVMERVHGRDLRDIVRE-------------------DGPYSPSQAATIMIPVCHALQSSH 128 Query: 360 SLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQL 539 GIIHRD+KP N++I+ G + K+ D GI++ L + S+++ G++ + +PEQ Sbjct: 129 EAGIIHRDVKPANIMINNTGGV--KVMDFGIARALDDSTSAMTQTAAVIGTAQYLSPEQA 186 Query: 540 RRASQTRAMDLFSLGCLIFYCIT-----KGKHPFGEYYE 641 R D+++ GC+++ +T +G+ PF Y+ Sbjct: 187 RGKPADARSDVYAAGCVLYELVTGRPPFEGESPFAVAYQ 225
>Q96PY6:NEK1_HUMAN Serine/threonine-protein kinase Nek1 - Homo sapiens (Human)| Length = 1258 Score = 75.9 bits (185), Expect = 4e-13 Identities = 62/257 (24%), Positives = 122/257 (47%), Gaps = 6/257 (2%) Frame = +3 Query: 3 KGSNG-TVVFEGSYDGREVAVKRLLRSHTDIAQKEIQN----LIASDRDPNIVRLYGCDQ 167 +GS G ++ + + DGR+ +K + S ++E ++A+ + PNIV+ + Sbjct: 12 EGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFE 71 Query: 168 DDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGI 347 ++ +YI ++ +C DL F + L+ +D Q+L + + Sbjct: 72 ENGSLYIVMD--YCEGGDL--------FKRINAQKGVLFQED-----QILDWFVQICLAL 116 Query: 348 VHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQA 527 H+H I+HRD+K QN+ ++K+G++ +L D GI++ L S++ T G+ + + Sbjct: 117 KHVHDRKILHRDIKSQNIFLTKDGTV--QLGDFGIARVLN---STVELARTCIGTPYYLS 171 Query: 528 PEQLRRASQTRAMDLFSLGCLIF-YCITKGKHPFGEYYERDINIINGHFDLFVVDHIPEA 704 PE D+++LGC+++ C K G + II+G F + + + Sbjct: 172 PEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDL 231 Query: 705 VHLISLLLQPKPDERPT 755 L+S L + P +RP+ Sbjct: 232 RSLVSQLFKRNPRDRPS 248
>O08648:M3K4_MOUSE Mitogen-activated protein kinase kinase kinase 4 - Mus musculus| (Mouse) Length = 1597 Score = 75.9 bits (185), Expect = 4e-13 Identities = 61/224 (27%), Positives = 103/224 (45%), Gaps = 8/224 (3%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PN+VR +G + +YI +E C + + +V ++ GL Sbjct: 1387 KHPNLVRYFGVELHREEMYIFMEYCD-----------EGTLEEVSRL--------GLQEH 1427 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSL- 485 + + + I LH GI+HRD+K N+ ++ G + KL D G S +L+ + ++ Sbjct: 1428 VIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLI--KLGDFGCSVKLKNNAQTMP 1485 Query: 486 SHHGTGYGSSGWQAPEQLRRA---SQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINI 656 + G++ + APE + RA RA D++SLGC++ +T GK P+ E YE + I Sbjct: 1486 GEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVT-GKRPWHE-YEHNFQI 1543 Query: 657 I----NGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMYAINH 776 + GH PE +S L+ P R TA ++H Sbjct: 1544 MYKVGMGHKPPIPERLSPEGKAFLSHCLESDPKIRWTASQLLDH 1587
>Q9BZL6:KPCD2_HUMAN Serine/threonine-protein kinase D2 - Homo sapiens (Human)| Length = 878 Score = 75.9 bits (185), Expect = 4e-13 Identities = 76/264 (28%), Positives = 126/264 (47%), Gaps = 11/264 (4%) Frame = +3 Query: 21 VVFEGSY--DGREVAVKRLLRSHTDIAQK-EIQNLIA---SDRDPNIVRLYGCDQDDNFV 182 VV+ G + GR+VAVK + + Q+ +++N +A S R P IV L + V Sbjct: 564 VVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKV 623 Query: 183 YISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLK-LMRDVVAGIVHLH 359 ++ +E+ H + ++I L ++ G +L K L+ ++ + HLH Sbjct: 624 FVVMEKLHGDMLEMI-----------------LSSEKGRLPERLTKFLITQILVALRHLH 666 Query: 360 SLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQ 536 I+H DLKP+NVL+ S + KL D G ++ + E S + G+ + APE Sbjct: 667 FKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK----SFRRSVVGTPAYLAPEV 722 Query: 537 LRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHF--DLFVVDHIPE-AV 707 L R++D++S+G +I Y G PF E + + I N F HI A+ Sbjct: 723 LLNQGYNRSLDMWSVG-VIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAI 781 Query: 708 HLISLLLQPKPDERPTAMYAINHP 779 LI+ LLQ K +R + +++HP Sbjct: 782 DLINNLLQVKMRKRYSVDKSLSHP 805
>Q07250:KCCS_MALDO Calcium/calmodulin-dependent serine/threonine-protein kinase -| Malus domestica (Apple) (Malus sylvestris) Length = 415 Score = 75.9 bits (185), Expect = 4e-13 Identities = 66/253 (26%), Positives = 119/253 (47%), Gaps = 9/253 (3%) Frame = +3 Query: 48 REVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCS-LADL 224 ++V++ +L ++ + ++I ++ PN++ LY +D+N V++ LE C L D Sbjct: 81 KQVSISNVLLTNEILVMRKIVENVSPH--PNVIDLYDVYEDENGVHLVLELCSGGELFDR 138 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 I + E +++ G + ++R + G+ LH I+HRDLKP+N L Sbjct: 139 I-------------VKQERYSEVGAAA-----VVRQIAQGLAALHRSNIVHRDLKPENCL 180 Query: 405 -ISKEGSLSAKLSDMGIS--KRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLF 575 + K+ D G+S + + + L +GS + +PE L + T D++ Sbjct: 181 FLDNTVDSPLKIMDFGLSSVEEFTDPVVGL------FGSIDYVSPEALSQGQVTSKSDMW 234 Query: 576 SLGCLIFYCITKGKHPFGEYYERDIN--IINGHFDLFV---VDHIPEAVHLISLLLQPKP 740 +LG +I Y + G PF R I+ G F + + + LIS LL+ P Sbjct: 235 ALG-VILYILLSGYPPFIAQSNRQKQQMIMAGEFSFYEKTWKGFLCQPKQLISSLLKVDP 293 Query: 741 DERPTAMYAINHP 779 D+RP+A ++HP Sbjct: 294 DKRPSAQELLDHP 306
>Q07494:EPHB1_CHICK Ephrin type-B receptor 1 - Gallus gallus (Chicken)| Length = 984 Score = 75.9 bits (185), Expect = 4e-13 Identities = 63/247 (25%), Positives = 114/247 (46%), Gaps = 7/247 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +++ +++ +++ PNI+RL G V I E D Sbjct: 648 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDS 707 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 708 FLRQNDGQFTVI----------------QLVGMLRGIAAGMKYLAEMNYVHRDLAARNIL 751 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ LQ+D S ++ + G W APE + T A D++S Sbjct: 752 VN--SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWS 809 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERP 752 G +++ ++ G+ P+ + +D IN I + L P A+H + L Q + RP Sbjct: 810 YGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNTRP 869 Query: 753 TAMYAIN 773 +N Sbjct: 870 RLAEIVN 876
>O09127:EPHA8_MOUSE Ephrin type-A receptor 8 precursor - Mus musculus (Mouse)| Length = 1004 Score = 75.9 bits (185), Expect = 4e-13 Identities = 62/228 (27%), Positives = 106/228 (46%), Gaps = 5/228 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEIQN---LIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ + ++ PNI+RL G I E Sbjct: 663 VAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTE--------- 713 Query: 225 IQQHTDPSFSDVEKIDVELWTQDG-LPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 + + +D L T DG QL+ ++R V AG+ +L LG IHRDL +NV Sbjct: 714 --------YMENGSLDAFLRTHDGQFTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNV 765 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L+ +G L K+SD G+S+ L++D + G W APE + + + A D++S Sbjct: 766 LV--DGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSF 823 Query: 582 GCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL 722 G +++ + G+ P+ +D I+ + + L P A+H + L Sbjct: 824 GVVMWEVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLML 871
>P54755:EPHA5_CHICK Ephrin type-A receptor 5 precursor - Gallus gallus (Chicken)| Length = 1013 Score = 75.9 bits (185), Expect = 4e-13 Identities = 84/354 (23%), Positives = 153/354 (43%), Gaps = 15/354 (4%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PNI+ L G V I E D Sbjct: 680 VAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDT 739 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + +G+ +L +G +HRDL +N+L Sbjct: 740 FLKKNDGQFTVI----------------QLVGMLRGIASGMKYLSDMGYVHRDLAARNIL 783 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 I+ +L K+SD G+S+ L++D + G W APE + T A D++S G Sbjct: 784 IN--SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYG 841 Query: 585 CLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERP-- 752 +++ ++ G+ P+ E +D I + + L P A++ + L Q + RP Sbjct: 842 IVMWEVMSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKF 901 Query: 753 TAMYAINHPLFWSPELRLLFLRDTSDRIEKTTETDLLNALESIGHQAFG--GKWREKLDD 926 + ++ L +P L L + S R+ ++LL +G A+ G+W E + Sbjct: 902 DEIVSMLDKLIRNPS-SLKTLVNASSRV-----SNLLVEHSPVGSGAYRSVGEWLEAIKM 955 Query: 927 GLVADVGRYRKYNFEST------RDLLRLIRNKSGHYRELPTDLKESLGSLPEG 1070 G ++ Y+ + DL RL GH +++ L+E L G Sbjct: 956 GRYTEIFMENGYSSMDSVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNG 1009
>Q43531:CCAMK_LILLO Calcium and calcium/calmodulin-dependent serine/threonine-protein| kinase - Lilium longiflorum (Trumpet lily) Length = 520 Score = 75.9 bits (185), Expect = 4e-13 Identities = 70/254 (27%), Positives = 119/254 (46%), Gaps = 10/254 (3%) Frame = +3 Query: 48 REVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLI 227 ++V+V L ++ + + I ++ PN++ L+ +D N V++ LE C Sbjct: 75 KQVSVSDALLTNEILVMRRIVEDVSPH--PNVIHLHDVYEDANGVHLVLELC-------- 124 Query: 228 QQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL- 404 S E D + QD + ++++ + +G+ LH IIHRDLKP+N L Sbjct: 125 --------SGGELFD-RIVAQDRYSESEAAEVVQQIASGLAALHKSTIIHRDLKPENCLF 175 Query: 405 ISKEGSLSAKLSDMGIS--KRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFS 578 +++E + K+ D G+S + + + +L +GS + +PE L + + A D++S Sbjct: 176 LNQEKRSTLKIMDFGLSSVEDFTDPIVAL------FGSIDYVSPEALSQRQVSSASDMWS 229 Query: 579 LGCLIFYCITKGKHPF--GEYYERDINIINGHFDLFVVDH-----IPEAVHLISLLLQPK 737 LG +I Y + G PF E+ I+ G F +H A LIS LL Sbjct: 230 LG-VILYILLSGCPPFHAPSNREKQQRILAGDFSF--EEHTWKTITSSAKDLISSLLSVD 286 Query: 738 PDERPTAMYAINHP 779 P +RPTA + HP Sbjct: 287 PYKRPTANDLLKHP 300
>Q23023:UNC51_CAEEL Serine/threonine-protein kinase unc-51 - Caenorhabditis elegans| Length = 856 Score = 75.5 bits (184), Expect = 5e-13 Identities = 81/312 (25%), Positives = 134/312 (42%), Gaps = 31/312 (9%) Frame = +3 Query: 21 VVFEGSYDGRE---VAVKRLLRSHT----DIAQKEIQNL--IASDRDPNIVRLYGCDQDD 173 +V+ G Y R VA+K + + + ++ KEI+ L ++S + N+V L C + Sbjct: 22 IVYRGRYVDRTDVPVAIKAIAKKNISKSKNLLTKEIKILKELSSLKHENLVGLLKCTETP 81 Query: 174 NFVYISLERCHCS-LADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIV 350 VY+ +E C+ LAD +QQ T + ++ V+ + + Sbjct: 82 THVYLVMEFCNGGDLADYLQQKTTLNEDTIQHFVVQ------------------IAHALE 123 Query: 351 HLHSLGIIHRDLKPQNVLISKEG--------SLSAKLSDMGISKRLQEDMSSLSHHGTGY 506 ++ GI+HRDLKPQN+L+ + KL+D G ++ L + + + T Sbjct: 124 AINKKGIVHRDLKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVMA----ATLC 179 Query: 507 GSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF--------GEYYERDINIIN 662 GS + APE + DL+S+G ++F C+T GK PF YYE+ + Sbjct: 180 GSPMYMAPEVIMSMQYDAKADLWSIGTILFQCLT-GKAPFVAQTPPQLKAYYEKTREL-- 236 Query: 663 GHFDLFVVDHIPE-----AVHLISLLLQPKPDERPTAMYAINHPLFWSPELRLLFLRDTS 827 +IPE L+ LL+ +R + NHP SP L S Sbjct: 237 -------RPNIPEWCSPNLRDLLLRLLKRNAKDRISFEDFFNHPFLTSP-----LLPSPS 284 Query: 828 DRIEKTTETDLL 863 RI ++ + LL Sbjct: 285 KRILESARSPLL 296
>Q9UEE5:ST17A_HUMAN Serine/threonine-protein kinase 17A - Homo sapiens (Human)| Length = 414 Score = 75.5 bits (184), Expect = 5e-13 Identities = 66/208 (31%), Positives = 107/208 (51%), Gaps = 8/208 (3%) Frame = +3 Query: 288 QDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSL-SAKLSDMGISKRL 464 ++ + +LMR ++ G+ LH+ ++H DLKPQN+L++ E L K+ D G+S+ L Sbjct: 155 EEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRIL 214 Query: 465 Q--EDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF--GE 632 + E++ + G+ + APE L + A D++S+G L + +T G PF + Sbjct: 215 KNSEELREI------MGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLT-GISPFLGND 267 Query: 633 YYERDINI--INGHFDLFVVDHIPE-AVHLISLLLQPKPDERPTAMYAINHPLFWSPELR 803 E +NI +N + D + E AV I LL KP++R TA + HP W L Sbjct: 268 KQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHP--W---LT 322 Query: 804 LLFLRDTSDRIEKTTETDLLNALESIGH 887 +++ S R+EK E NAL+ GH Sbjct: 323 QSSIQEPSFRMEKALEE--ANALQE-GH 347
>P08413:KCC2B_RAT Calcium/calmodulin-dependent protein kinase type II beta chain -| Rattus norvegicus (Rat) Length = 542 Score = 75.5 bits (184), Expect = 5e-13 Identities = 48/158 (30%), Positives = 88/158 (55%), Gaps = 6/158 (3%) Frame = +3 Query: 324 MRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGT 500 ++ ++ ++H H +G++HRDLKP+N+L+ SK + KL+D G++ +Q D + Sbjct: 117 IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFA- 175 Query: 501 GYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NIINGHFD 674 G+ G+ +PE LR+ + + +D+++ G +I Y + G PF + + + I G +D Sbjct: 176 --GTPGYLSPEVLRKEAYGKPVDIWACG-VILYILLVGYPPFWDEDQHKLYQQIKAGAYD 232 Query: 675 LFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 + PEA +LI+ +L P +R TA A+ HP Sbjct: 233 FPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHP 270
>P28652:KCC2B_MOUSE Calcium/calmodulin-dependent protein kinase type II beta chain -| Mus musculus (Mouse) Length = 542 Score = 75.5 bits (184), Expect = 5e-13 Identities = 48/158 (30%), Positives = 88/158 (55%), Gaps = 6/158 (3%) Frame = +3 Query: 324 MRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGT 500 ++ ++ ++H H +G++HRDLKP+N+L+ SK + KL+D G++ +Q D + Sbjct: 117 IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFA- 175 Query: 501 GYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NIINGHFD 674 G+ G+ +PE LR+ + + +D+++ G +I Y + G PF + + + I G +D Sbjct: 176 --GTPGYLSPEVLRKEAYGKPVDIWACG-VILYILLVGYPPFWDEDQHKLYQQIKAGAYD 232 Query: 675 LFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 + PEA +LI+ +L P +R TA A+ HP Sbjct: 233 FPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHP 270
>Q13554:KCC2B_HUMAN Calcium/calmodulin-dependent protein kinase type II beta chain -| Homo sapiens (Human) Length = 664 Score = 75.5 bits (184), Expect = 5e-13 Identities = 48/158 (30%), Positives = 88/158 (55%), Gaps = 6/158 (3%) Frame = +3 Query: 324 MRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGT 500 ++ ++ ++H H +G++HRDLKP+N+L+ SK + KL+D G++ +Q D + Sbjct: 117 IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFA- 175 Query: 501 GYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NIINGHFD 674 G+ G+ +PE LR+ + + +D+++ G +I Y + G PF + + + I G +D Sbjct: 176 --GTPGYLSPEVLRKEAYGKPVDIWACG-VILYILLVGYPPFWDEDQHKLYQQIKAGAYD 232 Query: 675 LFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 + PEA +LI+ +L P +R TA A+ HP Sbjct: 233 FPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHP 270
>Q2TA06:STK6_BOVIN Serine/threonine-protein kinase 6 - Bos taurus (Bovine)| Length = 402 Score = 75.1 bits (183), Expect = 6e-13 Identities = 63/219 (28%), Positives = 98/219 (44%), Gaps = 2/219 (0%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 R PNI+RLYG D VY+ LE ++ + + EL Sbjct: 189 RHPNILRLYGYFHDATRVYLILE-----------------YAPLGAVYRELQKLSKFDEQ 231 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLS 488 + + ++ + + HS +IHRD+KP+N+L+ G L K++D G S + S Sbjct: 232 RTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL--KIADFGWSVH-----APSS 284 Query: 489 HHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-GEYYERDINIING 665 T G+ + PE + +DL+SLG L + + GK PF + Y+ I+ Sbjct: 285 RRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPPFEADTYQETYRRIS- 342 Query: 666 HFDLFVVDHIPE-AVHLISLLLQPKPDERPTAMYAINHP 779 + D +PE A LIS LL+ P +RPT + HP Sbjct: 343 RVEFTFPDCVPEGARDLISRLLKHNPSQRPTLKEVLEHP 381
>P54761:EPHB4_MOUSE Ephrin type-B receptor 4 precursor - Mus musculus (Mouse)| Length = 987 Score = 75.1 bits (183), Expect = 6e-13 Identities = 81/342 (23%), Positives = 150/342 (43%), Gaps = 17/342 (4%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ ++E +++ PNI+RL G + V I E D Sbjct: 644 VAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDS 703 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + +G+ +L + +HRDL +N+L Sbjct: 704 FLRLNDGQFTVI----------------QLVGMLRGIASGMRYLAEMSYVHRDLAARNIL 747 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ L+E+ S ++ + G S W APE + T A D +S Sbjct: 748 VN--SNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKISIRWTAPEAIAFRKFTSASDAWS 805 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERP 752 G +++ ++ G+ P+ + +D IN I + L P ++H + L Q + RP Sbjct: 806 YGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARP 865 Query: 753 TAMYAIN--HPLFWSPELRLLFLRDTSDRIEKTTETDLLNALESIGHQAFG--GKWREKL 920 ++ + +P + R+ LL+ + + AFG G+W + Sbjct: 866 RFPQVVSALDKMIRNPASLKIVARENGG-----ASHPLLDQRQP-HYSAFGSVGEWLRAI 919 Query: 921 DDG------LVADVGRYRKYNFESTRDLLRLIRNKSGHYREL 1028 G A G + + S DLLR+ +GH +++ Sbjct: 920 KMGRYEESFAAAGFGSFEVVSQISAEDLLRIGVTLAGHQKKI 961
>Q60629:EPHA5_MOUSE Ephrin type-A receptor 5 precursor - Mus musculus (Mouse)| Length = 877 Score = 75.1 bits (183), Expect = 6e-13 Identities = 60/242 (24%), Positives = 107/242 (44%), Gaps = 3/242 (1%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PNI+ L G V I E D Sbjct: 543 VAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDT 602 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L +G +HRDL +N+L Sbjct: 603 FLKKNDGQFTVI----------------QLVGMLRGIAAGMKYLSDMGYVHRDLAARNIL 646 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 I+ +L K+SD G+S+ L++D + G W APE + T A D++S G Sbjct: 647 IN--SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYG 704 Query: 585 CLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMY 764 +++ ++ G+ P+ E +D V+ + E L P P + P A+Y Sbjct: 705 IVMWEVVSYGERPYWEMTNQD-----------VIKAVEEGYRL------PSPMDCPAALY 747 Query: 765 AI 770 + Sbjct: 748 QL 749
>Q6RET7:CCAMK_MEDTR Calcium and calcium/calmodulin-dependent serine/threonine-protein| kinase DMI-3 - Medicago truncatula (Barrel medic) Length = 523 Score = 75.1 bits (183), Expect = 6e-13 Identities = 69/254 (27%), Positives = 116/254 (45%), Gaps = 10/254 (3%) Frame = +3 Query: 48 REVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLI 227 R+V+V L ++ + + I ++ PN++ LY +D N V++ LE C Sbjct: 79 RQVSVSDTLLTNEILVMRRIVENVSPH--PNVIDLYDVYEDTNGVHLVLELC-------- 128 Query: 228 QQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL- 404 S E D + QD + ++ + +G+ +H I+HRDLKP+N L Sbjct: 129 --------SGGELFD-RIVAQDKYSETEAATVVHQIASGLEAVHRANIVHRDLKPENCLF 179 Query: 405 --ISKEGSLSAKLSDMGIS--KRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDL 572 + K+ L K+ D G+S + + + L +GS + +PE L + T D+ Sbjct: 180 LDVRKDSPL--KIMDFGLSSVEEFTDPVVGL------FGSIDYVSPEALSQGKITTKSDM 231 Query: 573 FSLGCLIFYCITKGKHPFGEYYERDIN--IINGHFDLFVVDH---IPEAVHLISLLLQPK 737 +SLG +I Y + G PF R I+NG+F + A +LIS LL Sbjct: 232 WSLG-VILYILLSGYPPFIAQNNRQKQQMIMNGNFSFYEKTWKGISQPAKNLISSLLTVD 290 Query: 738 PDERPTAMYAINHP 779 P +RP+A+ ++ P Sbjct: 291 PSKRPSALELLSDP 304
>Q20845:PLK3_CAEEL Serine/threonine-protein kinase plk-3 - Caenorhabditis elegans| Length = 615 Score = 74.7 bits (182), Expect = 8e-13 Identities = 60/209 (28%), Positives = 97/209 (46%), Gaps = 2/209 (0%) Frame = +3 Query: 138 NIVRLYGCDQDDNFVYISLERCHC-SLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQL 314 NIV+ + +D VY +LE C SL +L +Q + + ++ Sbjct: 94 NIVQFHHFFEDSQNVYFTLELCSKNSLMELNKQRGPLTEHEARFYTIQ------------ 141 Query: 315 LKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHH 494 V G+ HLH+L IIHRDLK N+ +++ L K+ D G++ +++ ++ Sbjct: 142 ------VAEGVKHLHNLQIIHRDLKLGNLFLNEH--LQVKIGDFGLATFCEKNEKKMTRG 193 Query: 495 GTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFD 674 GT + APE L +D++++GC I Y + G PF ++ + + D Sbjct: 194 GT----PNYIAPEVLNETGHAFEVDIWAIGC-ILYVLLFGSPPFESRRVQETYVRIKNND 248 Query: 675 LFVVDHI-PEAVHLISLLLQPKPDERPTA 758 V ++ P A LI LL P PD RPTA Sbjct: 249 YVVPENASPTANRLIRSLLDPVPDRRPTA 277
>Q8G6P9:PKNB_BIFLO Probable serine/threonine-protein kinase pknB - Bifidobacterium| longum Length = 690 Score = 74.7 bits (182), Expect = 8e-13 Identities = 58/205 (28%), Positives = 105/205 (51%), Gaps = 11/205 (5%) Frame = +3 Query: 45 GREVAVKRLLRSHTDIAQKEI--------QNLIASDRDPNIVRLYGCDQDDNFVYIS--- 191 GR VAVK + D+A +I + +A +PNIV +Y D + V Sbjct: 37 GRTVAVKIM---RADLANDDIFLARFRREAHAVAQMNNPNIVNIY--DSGEELVSSESGD 91 Query: 192 LERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGI 371 ER + + ++ T D+ K++ L +D ++M V+ + + H +GI Sbjct: 92 AERLPYIVMEYVKGQT---LRDIIKVNGALSQRD------CEQVMLGVLNALDYSHRMGI 142 Query: 372 IHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRAS 551 IHRD+KP N++IS++G + K+ D GI++ L + ++++ G++ + +PEQ R + Sbjct: 143 IHRDIKPGNIMISEQGVV--KVMDFGIARALDDSAATMTQSQGVVGTAQYLSPEQARGET 200 Query: 552 QTRAMDLFSLGCLIFYCITKGKHPF 626 DL+S GC+++ +T G+ PF Sbjct: 201 VDMRSDLYSAGCVLYEMLT-GRPPF 224
>Q9R0A5:NEK3_MOUSE Serine/threonine-protein kinase Nek3 - Mus musculus (Mouse)| Length = 511 Score = 74.7 bits (182), Expect = 8e-13 Identities = 62/234 (26%), Positives = 107/234 (45%), Gaps = 3/234 (1%) Frame = +3 Query: 66 RLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDP 245 RLL+S T ++KE L+A + PNIV + + ++YI +E +C DL+Q+ Sbjct: 36 RLLKSDTQTSRKEAV-LLAKMKHPNIVAFKESFEAEGYLYIVME--YCDGGDLMQR---- 88 Query: 246 SFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSL 425 ++ + P +L + G+ H+H ++HRD+K +NV ++ G + Sbjct: 89 ---------IKQQKGNLFPEDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKV 139 Query: 426 SAKLSDMGISKRLQEDMS-SLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYC 602 KL D G ++ L M+ + ++ GT Y + PE D++SLGC I Y Sbjct: 140 --KLGDFGSARLLSSPMAFACTYVGTPY----YVPPEIWENLPYNNKSDIWSLGC-ILYE 192 Query: 603 ITKGKHPF--GEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPKPDERPTA 758 + KHPF + + I G + + L+ +L+ P RP+A Sbjct: 193 LCALKHPFQANSWKNLILKICQGPIHPLPALYSCKLQGLVKQMLKRNPSHRPSA 246
>P06240:LCK_MOUSE Proto-oncogene tyrosine-protein kinase LCK - Mus musculus (Mouse)| Length = 509 Score = 74.7 bits (182), Expect = 8e-13 Identities = 70/251 (27%), Positives = 119/251 (47%), Gaps = 4/251 (1%) Frame = +3 Query: 24 VFEGSYDGR-EVAVKRLLR-SHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLE 197 V+ G Y+G +VAVK L + S + A NL+ + P +VRLY + I+ Sbjct: 259 VWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIYIITEY 318 Query: 198 RCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIH 377 + SL D ++ + K++V +LL + + G+ + IH Sbjct: 319 MENGSLVDFLKTPSGI------KLNVN----------KLLDMAAQIAEGMAFIEEQNYIH 362 Query: 378 RDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQT 557 RDL+ N+L+S +LS K++D G++ RL ED + G + W APE + + T Sbjct: 363 RDLRAANILVS--DTLSCKIADFGLA-RLIEDNEYTAREGAKFPIK-WTAPEAINYGTFT 418 Query: 558 RAMDLFSLGCLIFYCITKGKHPF-GEYYERDINIINGHFDLFVVDHIPEAV-HLISLLLQ 731 D++S G L+ +T G+ P+ G I + + + D+ PE + HL+ L + Sbjct: 419 IKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWK 478 Query: 732 PKPDERPTAMY 764 +P++RPT Y Sbjct: 479 ERPEDRPTFDY 489
>P29322:EPHA8_HUMAN Ephrin type-A receptor 8 precursor - Homo sapiens (Human)| Length = 1005 Score = 74.7 bits (182), Expect = 8e-13 Identities = 61/228 (26%), Positives = 106/228 (46%), Gaps = 5/228 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PNI+RL G I E Sbjct: 664 VAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTE--------- 714 Query: 225 IQQHTDPSFSDVEKIDVELWTQDG-LPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 + + +D L T DG QL+ ++R V AG+ +L LG +HRDL +NV Sbjct: 715 --------YMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNV 766 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L+ + +L K+SD G+S+ L++D + G W APE + + + A D++S Sbjct: 767 LV--DSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSF 824 Query: 582 GCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL 722 G +++ + G+ P+ RD I+ + + L P A+H + L Sbjct: 825 GVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLML 872
>Q9CAL3:CRK2_ARATH Cysteine-rich receptor-like protein kinase 2 precursor -| Arabidopsis thaliana (Mouse-ear cress) Length = 649 Score = 74.7 bits (182), Expect = 8e-13 Identities = 58/207 (28%), Positives = 99/207 (47%), Gaps = 5/207 (2%) Frame = +3 Query: 3 KGSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQ--NLIASDRDPNIVRLYGCDQDDN 176 +G GTV DGR++AVKRL ++ A N+I++ N+VRL GC Sbjct: 333 QGGFGTVYKGVLPDGRDIAVKRLFFNNRHRATDFYNEVNMISTVEHKNLVRLLGCS---- 388 Query: 177 FVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHL 356 CS + + + +++ ++ L + ++ G+V+L Sbjct: 389 ----------CSGPESLLVYEYLQNKSLDRFIFDVNRGKTLDWQRRYTIIVGTAEGLVYL 438 Query: 357 H---SLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQA 527 H S+ IIHRD+K N+L+ + L AK++D G+++ Q+D S +S G+ G+ A Sbjct: 439 HEQSSVKIIHRDIKASNILL--DSKLQAKIADFGLARSFQDDKSHIS--TAIAGTLGYMA 494 Query: 528 PEQLRRASQTRAMDLFSLGCLIFYCIT 608 PE L T +D++S G L+ +T Sbjct: 495 PEYLAHGQLTEMVDVYSFGVLVLEIVT 521
>Q9Z265:CHK2_MOUSE Serine/threonine-protein kinase Chk2 - Mus musculus (Mouse)| Length = 546 Score = 74.7 bits (182), Expect = 8e-13 Identities = 59/159 (37%), Positives = 86/159 (54%), Gaps = 10/159 (6%) Frame = +3 Query: 333 VVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYG 509 ++ + +LH GIIHRDLKP+NVL+ S+E K++D G SK L E +SL T G Sbjct: 335 MLVAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGE--TSLMR--TLCG 390 Query: 510 SSGWQAPEQL---RRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYER---DINIINGHF 671 + + APE L A +RA+D +SLG ++F C++ G PF E+ + I +G + Sbjct: 391 TPTYLAPEVLVSNGTAGYSRAVDCWSLGVILFICLS-GYPPFSEHKTQVSLKDQITSGKY 449 Query: 672 DLFV---VDHIPEAVHLISLLLQPKPDERPTAMYAINHP 779 + D EA+ L+ LL P R T A+NHP Sbjct: 450 NFIPEVWTDVSEEALDLVKKLLVVDPKARLTTEEALNHP 488
>Q09170:CDS1_SCHPO Serine/threonine-protein kinase cds1 - Schizosaccharomyces pombe| (Fission yeast) Length = 460 Score = 74.7 bits (182), Expect = 8e-13 Identities = 67/278 (24%), Positives = 129/278 (46%), Gaps = 30/278 (10%) Frame = +3 Query: 48 REVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLI 227 R++ + + T++ Q+EI +++ S P +V+ + ++D+ ++I +E + DL+ Sbjct: 201 RKILLTSSEKRATEMFQREI-DILKSLHHPGVVQCHEIFENDDELFIVME--YVEGGDLM 257 Query: 228 QQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI 407 D + + QD P L++ ++ ++HLH G+ HRD+KP+N+LI Sbjct: 258 ---------DFLIANGSIDEQDCKP------LLKQLLETLLHLHKQGVTHRDIKPENILI 302 Query: 408 SKEGSLSAKLSDMGISKRLQEDMSSLSHHGTG------YGSSGWQAPEQLRR------AS 551 + + L K+SD G++K + HGTG G+ G+ APE L+ Sbjct: 303 TNDFHL--KISDFGLAKVI---------HGTGTFLETFCGTMGYLAPEVLKSKNVNLDGG 351 Query: 552 QTRAMDLFSLGCLIFYCIT------------------KGKHPFGEYYERDINIINGHFDL 677 +D++SLGC+++ +T KG +P E +I+ Sbjct: 352 YDDKVDIWSLGCVLYVMLTASIPFASSSQAKCIELISKGAYPIEPLLENEIS-------- 403 Query: 678 FVVDHIPEAVHLISLLLQPKPDERPTAMYAINHPLFWS 791 E + LI+ +L+ P++R + A+ HP F++ Sbjct: 404 ------EEGIDLINRMLEINPEKRISESEALQHPWFYT 435
>P43063:CDC28_CANAL Cell division control protein 28 - Candida albicans (Yeast)| Length = 317 Score = 74.7 bits (182), Expect = 8e-13 Identities = 62/205 (30%), Positives = 105/205 (51%), Gaps = 9/205 (4%) Frame = +3 Query: 3 KGSNGTV--VFEGSYDGREVAVKRLLRSHTD-----IAQKEIQNLIASDRDPNIVRLYGC 161 +G+ G V + ++ R VA+K++ D A +EI +L+ +D NIVRLY Sbjct: 15 EGTYGVVYKALDTKHNNRVVALKKIRLESEDEGVPSTAIREI-SLLKEMKDDNIVRLYDI 73 Query: 162 DQDDNF-VYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVV 338 D+ +Y+ E DL D++K + GL + + + M ++ Sbjct: 74 IHSDSHKLYLVFE-----FLDL----------DLKKYMESIPQGVGLGANMIKRFMNQLI 118 Query: 339 AGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSG 518 GI H HS ++HRDLKPQN+LI KEG+L KL+D G+++ + + +H + Sbjct: 119 RGIKHCHSHRVLHRDLKPQNLLIDKEGNL--KLADFGLARAFGVPLRAYTHEVV---TLW 173 Query: 519 WQAPEQLRRASQ-TRAMDLFSLGCL 590 ++APE L Q + +D++S+GC+ Sbjct: 174 YRAPEILLGGKQYSTGVDMWSVGCI 198
>P54736:PKN2_MYXXA Serine/threonine-protein kinase pkn2 - Myxococcus xanthus| Length = 830 Score = 74.3 bits (181), Expect = 1e-12 Identities = 60/201 (29%), Positives = 98/201 (48%), Gaps = 7/201 (3%) Frame = +3 Query: 45 GREVAVKRL---LRSHTDIAQ--KEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHC 209 GR+VA+K L L + +A+ K L+++ P +VR+ + + + +E Sbjct: 36 GRKVAIKVLHHDLHAQAGMAERFKREARLLSAVEHPAVVRIVDFGESGDHACLVME---- 91 Query: 210 SLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLK 389 F + E + ++ T +P + L L++ + G+ +H GIIHRDLK Sbjct: 92 -------------FVEGESL-YDVLTPGPMPPGRALPLLQQLAEGLAAIHDKGIIHRDLK 137 Query: 390 PQNVLISKEG-SLSAKLSDMGISKRLQED-MSSLSHHGTGYGSSGWQAPEQLRRASQTRA 563 P+NV ISK A+L D GI++ ++ D SS+S G G+ + +PEQ A Sbjct: 138 PENVFISKSARGEQARLLDFGIARLVEPDAASSVSQIGVVLGTPEYLSPEQAVGAKVDTR 197 Query: 564 MDLFSLGCLIFYCITKGKHPF 626 DL+S G L Y + G+ PF Sbjct: 198 SDLYSFGVLT-YRVLSGRLPF 217
>Q62101:KPCD1_MOUSE Serine/threonine-protein kinase D1 - Mus musculus (Mouse)| Length = 918 Score = 74.3 bits (181), Expect = 1e-12 Identities = 77/286 (26%), Positives = 136/286 (47%), Gaps = 14/286 (4%) Frame = +3 Query: 21 VVFEGSY--DGREVAVKRLLRSHTDIAQK-EIQNLIASDRD---PNIVRLYGCDQDDNFV 182 +V+ G + GR+VA+K + + Q+ +++N +A ++ P +V L + V Sbjct: 602 IVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERV 661 Query: 183 YISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDG-LPSPQLLKLMRDVVAGIVHLH 359 ++ +E+ H + ++I L ++ G LP L+ ++ + HLH Sbjct: 662 FVVMEKLHGDMLEMI-----------------LSSEKGWLPEHITKFLITQILVALRHLH 704 Query: 360 SLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQ 536 I+H DLKP+NVL+ S + KL D G ++ + E S + G+ + APE Sbjct: 705 FKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK----SFRRSVVGTPAYLAPEV 760 Query: 537 LRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHF-----DLFVVDHIPE 701 LR R++D++S+G +I+ ++ G PF E + I N F + H E Sbjct: 761 LRNKGYNRSLDMWSVGVIIYVSLS-GTFPFNEDEDIHDQIQNAAFMYPPNPWKEISH--E 817 Query: 702 AVHLISLLLQPKPDERPTAMYAINHPLFWSPELRL-LFLRDTSDRI 836 A+ LI+ LLQ K +R + ++HP W + + L LR+ RI Sbjct: 818 AIDLINNLLQVKMRKRYSVDKTLSHP--WLQDYQTWLDLRELECRI 861
>Q15139:KPCD1_HUMAN Serine/threonine-protein kinase D1 - Homo sapiens (Human)| Length = 912 Score = 74.3 bits (181), Expect = 1e-12 Identities = 82/307 (26%), Positives = 145/307 (47%), Gaps = 17/307 (5%) Frame = +3 Query: 21 VVFEGSY--DGREVAVKRLLRSHTDIAQK-EIQNLIASDRD---PNIVRLYGCDQDDNFV 182 +V+ G + GR+VA+K + + Q+ +++N +A ++ P +V L + V Sbjct: 596 IVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERV 655 Query: 183 YISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDG-LPSPQLLKLMRDVVAGIVHLH 359 ++ +E+ H + ++I L ++ G LP L+ ++ + HLH Sbjct: 656 FVVMEKLHGDMLEMI-----------------LSSEKGRLPEHITKFLITQILVALRHLH 698 Query: 360 SLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQ 536 I+H DLKP+NVL+ S + KL D G ++ + E S + G+ + APE Sbjct: 699 FKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK----SFRRSVVGTPAYLAPEV 754 Query: 537 LRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHF-----DLFVVDHIPE 701 LR R++D++S+G +I+ ++ G PF E + I N F + H E Sbjct: 755 LRNKGYNRSLDMWSVGVIIYVSLS-GTFPFNEDEDIHDQIQNAAFMYPPNPWKEISH--E 811 Query: 702 AVHLISLLLQPKPDERPTAMYAINHPLFWSPELRL-LFLRDTSDRIEK---TTETDLLNA 869 A+ LI+ LLQ K +R + ++HP W + + L LR+ +I + T E+D L Sbjct: 812 AIDLINNLLQVKMRKRYSVDKTLSHP--WLQDYQTWLDLRELECKIGERYITHESDDLRW 869 Query: 870 LESIGHQ 890 + G Q Sbjct: 870 EKYAGEQ 876
>P28693:EPHB2_CHICK Ephrin type-B receptor 2 precursor - Gallus gallus (Chicken)| Length = 1004 Score = 74.3 bits (181), Expect = 1e-12 Identities = 57/229 (24%), Positives = 108/229 (47%), Gaps = 6/229 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PN++ L G + V I E D Sbjct: 668 VAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDS 727 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 728 FLRQNDGQFTVI----------------QLVGMLRGIAAGMKYLADMNYVHRDLAARNIL 771 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ L++D S ++ G W APE ++ T A D++S Sbjct: 772 VN--SNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWS 829 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL 722 G +++ ++ G+ P+ + +D IN I + L P A+H + L Sbjct: 830 YGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPNALHQLML 878
>Q9QY01:ULK2_MOUSE Serine/threonine-protein kinase ULK2 - Mus musculus (Mouse)| Length = 1037 Score = 73.9 bits (180), Expect = 1e-12 Identities = 64/227 (28%), Positives = 105/227 (46%), Gaps = 15/227 (6%) Frame = +3 Query: 21 VVFEGSYDGR---EVAVKRLLRSHTDIAQ----KEIQNLIASDRDPNIVRLYGCDQDDNF 179 VVF G + + EVA+K + + + +Q KEI+ ++ + NIV LY + N Sbjct: 22 VVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIK-ILKELQHENIVALYDVQELPNS 80 Query: 180 VYISLERCHCS-LADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHL 356 V++ +E C+ LAD +Q + L + + + A + L Sbjct: 81 VFLVMEYCNGGDLADYLQ------------------AKGTLSEDTIRVFLHQIAAAMRIL 122 Query: 357 HSLGIIHRDLKPQNVLI-------SKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSS 515 HS GIIHRDLKPQN+L+ S + K++D G ++ L + + T GS Sbjct: 123 HSKGIIHRDLKPQNILLSYANRRKSNVSGIRIKIADFGFARYLHSNTMA----ATLCGSP 178 Query: 516 GWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINI 656 + APE + DL+S+G +I+ C+ GK PF +D+ + Sbjct: 179 MYMAPEVIMSQHYDAKADLWSIGTVIYQCLV-GKPPFQANSPQDLRM 224
>Q9ESG9:PMYT1_MOUSE Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase - Mus musculus (Mouse) Length = 490 Score = 73.9 bits (180), Expect = 1e-12 Identities = 79/273 (28%), Positives = 114/273 (41%), Gaps = 10/273 (3%) Frame = +3 Query: 6 GSNGTVV-FEGSYDGREVAVKRLL---RSHTDIAQK--EIQNLIASDRDPNIVRLYGCDQ 167 GS G V DGR AVKR + R D +K E+ + P+ VRL + Sbjct: 110 GSYGEVFKVRSKEDGRLYAVKRYMSPFRGPKDRTRKLAEVGGHEKVGQHPHCVRLERAWE 169 Query: 168 DDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGI 347 + +Y+ E C SL QQH E W LP Q+ +RD++ + Sbjct: 170 EGGILYLQTELCGPSL----QQHC------------EAWGAS-LPEAQVWGYLRDILLAL 212 Query: 348 VHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSG--- 518 HLHS G++H D+KP N+ + G KL D G+ + L G G G Sbjct: 213 DHLHSQGLVHLDVKPANIFLGPRG--RCKLGDFGL-------LVELGSTGAGEAQEGDPR 263 Query: 519 WQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHF-DLFVVDHI 695 + APE L + S A D+FSLG I + P G E + G+ F Sbjct: 264 YMAPE-LLQGSYGTAADVFSLGLTILEVACNMELPHGG--EGWQQLRQGYLPPEFTAGLS 320 Query: 696 PEAVHLISLLLQPKPDERPTAMYAINHPLFWSP 794 E +++++L+P P R TA + P+ P Sbjct: 321 SELRSVLAMMLEPDPQLRATAEALLALPMLRQP 353
>O18209:PMY13_CAEEL Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase wee-1.3 - Caenorhabditis elegans Length = 677 Score = 73.9 bits (180), Expect = 1e-12 Identities = 64/241 (26%), Positives = 108/241 (44%), Gaps = 4/241 (1%) Frame = +3 Query: 72 LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSF 251 +R H+ +E ++ + N+V+ Y ++ +YI E C SL + Sbjct: 143 IRQHSISKYREAESHMIIPPHKNLVKFYRAWEETGRLYIQTELCDQSLLKYCTE------ 196 Query: 252 SDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSA 431 + LP ++ + D++ + HLHS +IH D+KP+N+ ++K+ + Sbjct: 197 ------------KHALPEDEIWNIFVDLLQAVHHLHSNDMIHDDIKPENIFLTKD--MIC 242 Query: 432 KLSDMGISKRLQ--EDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCI 605 KL D G+ L+ D+ S G S + APE L T++ D+FSLG I Sbjct: 243 KLGDFGLVINLKNPNDVKSAEE-----GDSKYLAPEVL-NGRPTKSSDIFSLGMTILEAT 296 Query: 606 TKGKHPF-GEYYERDINIINGHF-DLFVVDHIPEAVHLISLLLQPKPDERPTAMYAINHP 779 T P G+ + + I NG D F + LI+L+L P RPT+ ++HP Sbjct: 297 TDLDVPSNGDSWHQ---IRNGQIPDRFFAGISTDLRSLIALMLDSDPRIRPTSRDLLDHP 353 Query: 780 L 782 + Sbjct: 354 V 354
>Q15349:KS6A2_HUMAN Ribosomal protein S6 kinase alpha-2 - Homo sapiens (Human)| Length = 733 Score = 73.9 bits (180), Expect = 1e-12 Identities = 77/254 (30%), Positives = 117/254 (46%), Gaps = 11/254 (4%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCS-LADLI 227 E AVK + +S D ++ EI+ L+ + PNI+ L D FVY+ +E L D I Sbjct: 440 EYAVKIIDKSKRDPSE-EIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRI 498 Query: 228 QQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI 407 + FS+ E DV + + + +LHS G++HRDLKP N+L Sbjct: 499 LRQR--YFSEREASDV----------------LCTITKTMDYLHSQGVVHRDLKPSNILY 540 Query: 408 SKEGSL--SAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 E S ++ D G +K+L+ L T ++ + APE L+R A D++SL Sbjct: 541 RDESGSPESIRVCDFGFAKQLRAGNGLLM---TPCYTANFVAPEVLKRQGYDAACDIWSL 597 Query: 582 GCLIFYCITKGKHPFGE-----YYERDINIINGHFDLF--VVDHIPEAV-HLISLLLQPK 737 G L+ Y + G PF E I +G + L D I +A ++S +L Sbjct: 598 GILL-YTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVD 656 Query: 738 PDERPTAMYAINHP 779 P +R TAM + HP Sbjct: 657 PHQRLTAMQVLKHP 670 Score = 71.6 bits (174), Expect = 7e-12 Identities = 64/219 (29%), Positives = 107/219 (48%), Gaps = 11/219 (5%) Frame = +3 Query: 3 KGSNGTVVF----EGSYDGREVAVKRL----LRSHTDIAQKEIQNLIASDRDPNIVRLYG 158 +GS G V +GS G+ A+K L L+ + K ++++A P IV+L+ Sbjct: 67 QGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHY 126 Query: 159 CDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVV 338 Q + +Y+ L+ DL + + E DV+ + + ++ Sbjct: 127 AFQTEGKLYLILDFLRGG--DLFTRLSKEVMFTEE--DVKFY-------------LAELA 169 Query: 339 AGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGY---G 509 + HLHSLGII+RDLKP+N+L+ +EG + K++D G+SK ++ H Y G Sbjct: 170 LALDHLHSLGIIYRDLKPENILLDEEGHI--KITDFGLSK------EAIDHDKRAYSFCG 221 Query: 510 SSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF 626 + + APE + R T++ D +S G L+F +T G PF Sbjct: 222 TIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT-GSLPF 259
>P54763:EPHB2_MOUSE Ephrin type-B receptor 2 precursor - Mus musculus (Mouse)| Length = 994 Score = 73.9 bits (180), Expect = 1e-12 Identities = 57/229 (24%), Positives = 107/229 (46%), Gaps = 6/229 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PN++ L G V I E D Sbjct: 658 VAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDS 717 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 718 FLRQNDGQFTVI----------------QLVGMLRGIAAGMKYLADMNYVHRDLAARNIL 761 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ L++D S ++ G W APE ++ T A D++S Sbjct: 762 VN--SNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWS 819 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL 722 G +++ ++ G+ P+ + +D IN I + L P A+H + L Sbjct: 820 YGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLML 868
>P29323:EPHB2_HUMAN Ephrin type-B receptor 2 precursor - Homo sapiens (Human)| Length = 1055 Score = 73.9 bits (180), Expect = 1e-12 Identities = 57/229 (24%), Positives = 107/229 (46%), Gaps = 6/229 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PN++ L G V I E D Sbjct: 650 VAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDS 709 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 710 FLRQNDGQFTVI----------------QLVGMLRGIAAGMKYLADMNYVHRDLAARNIL 753 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ L++D S ++ G W APE ++ T A D++S Sbjct: 754 VN--SNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWS 811 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL 722 G +++ ++ G+ P+ + +D IN I + L P A+H + L Sbjct: 812 YGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLML 860
>P54757:EPHA5_RAT Ephrin type-A receptor 5 precursor - Rattus norvegicus (Rat)| Length = 1005 Score = 73.9 bits (180), Expect = 1e-12 Identities = 60/242 (24%), Positives = 106/242 (43%), Gaps = 3/242 (1%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA K L +T+ +++ +++ PNI+ L G V I E D Sbjct: 706 VATKTLKVGYTEKQRRDFLSEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDT 765 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L +G +HRDL +N+L Sbjct: 766 FLKKNDGQFTVI----------------QLVGMLRGIAAGMKYLSDMGYVHRDLAARNIL 809 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 I+ +L K+SD G+S+ L++D + G W APE + T A D++S G Sbjct: 810 IN--SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYG 867 Query: 585 CLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMY 764 +++ ++ G+ P+ E +D V+ + E L P P + P A+Y Sbjct: 868 IVMWEVVSYGERPYWEMTNQD-----------VIKAVEEGYRL------PSPMDCPAALY 910 Query: 765 AI 770 + Sbjct: 911 QL 912
>Q6PA14:STK4_XENLA Serine/threonine-protein kinase 4 - Xenopus laevis (African clawed| frog) Length = 485 Score = 73.6 bits (179), Expect = 2e-12 Identities = 66/273 (24%), Positives = 125/273 (45%), Gaps = 14/273 (5%) Frame = +3 Query: 3 KGSNGTVVFEGSYDGREVAVKRLLRSHTDIAQ--KEIQNLIASDRDPNIVRLYGCDQDDN 176 +GS G+V + ++ + + +D+ + KEI + D P++V+ YG + Sbjct: 38 EGSYGSVYKASHKETSQIVAIKQIPVESDLQEIIKEISIMQQCD-SPHVVKYYGSYFKNT 96 Query: 177 FVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHL 356 ++I +E C S SD+ ++ + +D ++ +++ + G+ +L Sbjct: 97 DLWIVMEFCGGG-----------SVSDIIRLRKQTLNED-----EIATILQSTLKGLEYL 140 Query: 357 HSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQ 536 H + IHRD+K N+L+S EG +AKL+D G++ +L + M+ T G+ W APE Sbjct: 141 HFMRKIHRDIKAGNILLSCEG--TAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEV 195 Query: 537 LRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------ 698 ++ D++SLG + +GK P+ E I+ +F++ P Sbjct: 196 IQEIGYNCVADIWSLGITAIE-MAEGKPPYAE--------IHPMRAIFMIPSNPPPTFRK 246 Query: 699 ------EAVHLISLLLQPKPDERPTAMYAINHP 779 + V I+L L P+ R +A + HP Sbjct: 247 PELWSKDFVDFINLCLVKNPELRSSATELLQHP 279
>Q17446:PMK1_CAEEL Mitogen-activated protein kinase pmk-1 - Caenorhabditis elegans| Length = 377 Score = 73.6 bits (179), Expect = 2e-12 Identities = 75/303 (24%), Positives = 130/303 (42%), Gaps = 46/303 (15%) Frame = +3 Query: 6 GSNGTV-VFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFV 182 G+ GTV E + G VA+K+ R Q++I + R +RL C Sbjct: 44 GAYGTVCAAECTRSGTRVAIKKFNRP--------FQSIIHARRTYRELRLLRC------- 88 Query: 183 YISLERCHCSLADLIQQHT-DPSFSDVEKIDVELWTQDGLPSPQLLKLMR---------- 329 CH ++ DL+ T + + +D+E + G +LK+ R Sbjct: 89 -----MCHENIIDLLDVFTPNENVNDIEDVYFVSMLM-GADLSNILKIQRLNDDHIQFLV 142 Query: 330 -DVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGY 506 ++ G+ ++HS IIHRDLKP N+ ++++ L K+ D G++++ +M TGY Sbjct: 143 YQILRGLKYIHSADIIHRDLKPSNIAVNEDCEL--KILDFGLARQTDSEM-------TGY 193 Query: 507 GSSGW-QAPE-QLRRASQTRAMDLFSLGCLIFYCIT-KGKHPFGEYYERDINIIN----- 662 ++ W +APE L T+ +D++S+GC++ IT K P ++ ++ I++ Sbjct: 194 VATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELITGKTLFPGSDHIDQLTRIMSVTGTP 253 Query: 663 -------------------------GHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMYA 767 F P+A+ L+ +L PD RPTA A Sbjct: 254 DEEFLKKISSEEARNYIRNLPKMTRRDFKRLFAQATPQAIDLLEKMLHLDPDRRPTAKEA 313 Query: 768 INH 776 + H Sbjct: 314 MEH 316
>P50528:PLO1_SCHPO Serine/threonine-protein kinase plo1 - Schizosaccharomyces pombe| (Fission yeast) Length = 683 Score = 73.6 bits (179), Expect = 2e-12 Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 9/226 (3%) Frame = +3 Query: 135 PNIVRLYGCDQDDNFVYISLERC-HCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQ 311 PNIV C +D +Y+ LE C H SL +L+++ L P+ Sbjct: 98 PNIVGFIDCFEDSTNIYLILELCEHKSLMELLRKRKQ------------------LTEPE 139 Query: 312 LLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSH 491 + LM ++ + ++H +IHRDLK N+++ + S + K+ D G++ L +D Sbjct: 140 VRYLMMQILGALKYMHKKRVIHRDLKLGNIMLDE--SNNVKIGDFGLAALLMDDE---ER 194 Query: 492 HGTGYGSSGWQAPEQLRRASQTRA--MDLFSLGCLIFYCITKGKHPFGEYYERDINII-- 659 T G+ + APE L + + + +DL+S G ++ Y + GK PF ++++ I Sbjct: 195 KMTICGTPNYIAPEILFNSKEGHSFEVDLWSAG-VVMYALLIGKPPF---QDKEVKTIYR 250 Query: 660 ----NGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMYAINHPLF 785 N + VD EA LIS LL P RP+ ++H F Sbjct: 251 KIKANSYSFPSNVDISAEAKDLISSLLTHDPSIRPSIDDIVDHEFF 296
>Q8XJL8:PKN2_CLOPE Probable serine/threonine protein kinase CPE1738 - Clostridium| perfringens Length = 685 Score = 73.6 bits (179), Expect = 2e-12 Identities = 59/199 (29%), Positives = 102/199 (51%), Gaps = 6/199 (3%) Frame = +3 Query: 48 REVAVKRL---LRSHTDIAQ--KEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHC- 209 R VAVK L +++ +I + K+ IA+ +PN+V + D+ YI +E Sbjct: 34 RFVAVKILKDEFKNNEEIVRRFKKEATAIANLSNPNVVNVLDVGTQDDINYIVMEYVEGK 93 Query: 210 SLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLK 389 +L D+I++ + LP + + V + H GIIHRD+K Sbjct: 94 TLKDIIKE------------------KGALPYEVAISIGIKVAKALECAHKSGIIHRDVK 135 Query: 390 PQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMD 569 PQN+L+++EG + K++D GI+K + D S+++H + GS+ + +PEQ + D Sbjct: 136 PQNILVTEEGVV--KVTDFGIAKSM--DSSTIAHTNSVMGSAHYFSPEQAKGTYTDYRTD 191 Query: 570 LFSLGCLIFYCITKGKHPF 626 L+SLG +++ +T G PF Sbjct: 192 LYSLGIVLYEMVT-GVVPF 209
>Q9S7U9:M2K2_ARATH Mitogen-activated protein kinase kinase 2 - Arabidopsis thaliana| (Mouse-ear cress) Length = 363 Score = 73.6 bits (179), Expect = 2e-12 Identities = 74/277 (26%), Positives = 128/277 (46%), Gaps = 18/277 (6%) Frame = +3 Query: 3 KGSNGTV-VFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIA---SDRDPNIVRLYGCDQD 170 KGS+G V + + + G+ A+K + + + +K I + S + PN+V Y D Sbjct: 78 KGSSGVVQLVQHKWTGQFFALKVIQLNIDEAIRKAIAQELKINQSSQCPNLVTSYQSFYD 137 Query: 171 DNFVYISLERCHC-SLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGI 347 + + + LE SLAD ++ + +P L + R V+ G+ Sbjct: 138 NGAISLILEYMDGGSLADFLK------------------SVKAIPDSYLSAIFRQVLQGL 179 Query: 348 VHLH-SLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQ 524 ++LH IIHRDLKP N+LI+ G + K++D G+S + + + L++ T G+ + Sbjct: 180 IYLHHDRHIIHRDLKPSNLLINHRGEV--KITDFGVS-TVMTNTAGLAN--TFVGTYNYM 234 Query: 525 APEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLF--VVDHIP 698 +PE++ D++SLG ++ C T GK P+ + + F+L +VD P Sbjct: 235 SPERIVGNKYGNKSDIWSLGLVVLECAT-GKFPYAPPNQEE--TWTSVFELMEAIVDQPP 291 Query: 699 EAV----------HLISLLLQPKPDERPTAMYAINHP 779 A+ IS LQ P+ R +A + HP Sbjct: 292 PALPSGNFSPELSSFISTCLQKDPNSRSSAKELMEHP 328
>Q9WUT3:KS6A2_MOUSE Ribosomal protein S6 kinase alpha-2 - Mus musculus (Mouse)| Length = 733 Score = 73.6 bits (179), Expect = 2e-12 Identities = 77/254 (30%), Positives = 120/254 (47%), Gaps = 11/254 (4%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCS-LADLI 227 E AVK + +S D ++ EI+ L+ + PNI+ L D +VY+ +E L D I Sbjct: 440 EYAVKIIDKSKRDPSE-EIEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRI 498 Query: 228 QQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI 407 + FS+ E DV L+T + + +LHS G++HRDLKP N+L Sbjct: 499 LRQR--CFSEREASDV-LYT---------------IARTMDYLHSQGVVHRDLKPSNILY 540 Query: 408 SKEGS--LSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 E S ++ D G +K+L+ + L T ++ + APE L+R A D++SL Sbjct: 541 MDESGNPESIRICDFGFAKQLRAENGLLM---TPCYTANFVAPEVLKRQGYDAACDVWSL 597 Query: 582 GCLIFYCITKGKHPFGE-----YYERDINIINGHFDLF--VVDHIPEAV-HLISLLLQPK 737 G L+ Y + G PF E I +G + L D I +A ++S +L Sbjct: 598 GILL-YTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVD 656 Query: 738 PDERPTAMYAINHP 779 P +R TA+ + HP Sbjct: 657 PQQRLTAVQVLKHP 670 Score = 68.9 bits (167), Expect = 4e-11 Identities = 57/199 (28%), Positives = 96/199 (48%), Gaps = 1/199 (0%) Frame = +3 Query: 33 GSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCS 212 G +V K L+ + K ++++A P IV+L+ Q + +Y+ L+ Sbjct: 85 GQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGG 144 Query: 213 LADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKP 392 DL + + E DV+ + + ++ + HLH LGII+RDLKP Sbjct: 145 --DLFTRLSKEVMFTEE--DVKFY-------------LAELALALDHLHGLGIIYRDLKP 187 Query: 393 QNVLISKEGSLSAKLSDMGISKRLQE-DMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMD 569 +N+L+ +EG + K++D G+SK + D + S GT + APE + R T++ D Sbjct: 188 ENILLDEEGHI--KITDFGLSKEATDHDKRAYSFCGT----IEYMAPEVVNRRGHTQSAD 241 Query: 570 LFSLGCLIFYCITKGKHPF 626 +S G L+F +T G PF Sbjct: 242 WWSFGVLMFEMLT-GSLPF 259
>P54760:EPHB4_HUMAN Ephrin type-B receptor 4 precursor - Homo sapiens (Human)| Length = 987 Score = 73.6 bits (179), Expect = 2e-12 Identities = 80/342 (23%), Positives = 149/342 (43%), Gaps = 17/342 (4%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ ++E +++ PNI+RL G + V I E D Sbjct: 644 VAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDS 703 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + +G+ +L + +HRDL +N+L Sbjct: 704 FLRLNDGQFTVI----------------QLVGMLRGIASGMRYLAEMSYVHRDLAARNIL 747 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ L+E+ S ++ + G W APE + T A D +S Sbjct: 748 VN--SNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWS 805 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERP 752 G +++ ++ G+ P+ + +D IN I + L P ++H + L Q + RP Sbjct: 806 YGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARP 865 Query: 753 TAMYAIN--HPLFWSPELRLLFLRDTSDRIEKTTETDLLNALESIGHQAFG--GKWREKL 920 ++ + +P + R+ LL+ + + AFG G+W + Sbjct: 866 RFPQVVSALDKMIRNPASLKIVARENGG-----ASHPLLDQRQP-HYSAFGSVGEWLRAI 919 Query: 921 DDG------LVADVGRYRKYNFESTRDLLRLIRNKSGHYREL 1028 G A G + + S DLLR+ +GH +++ Sbjct: 920 KMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKKI 961
>P29321:EPHA8_RAT Ephrin type-A receptor 8 - Rattus norvegicus (Rat)| Length = 372 Score = 73.6 bits (179), Expect = 2e-12 Identities = 60/228 (26%), Positives = 105/228 (46%), Gaps = 5/228 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEIQN---LIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ ++ PNI+RL G I E Sbjct: 31 VAIKALKAGYTERQRQDFLREAAIMGQFDHPNIIRLEGVVTRGRLAMIVTE--------- 81 Query: 225 IQQHTDPSFSDVEKIDVELWTQDG-LPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 + + +D L T DG QL+ +++ V AG+ +L LG IHRDL +N+ Sbjct: 82 --------YMENGSLDAFLRTHDGQFTILQLVGMLKGVGAGMRYLSDLGYIHRDLAARNI 133 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L+ +G L K+SD G+S+ L++D + G W APE + + + A D++S Sbjct: 134 LV--DGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSF 191 Query: 582 GCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL 722 G +++ + G+ P+ +D I+ + + L P A+H + L Sbjct: 192 GVVMWEVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLML 239
>O42422:EPHA7_CHICK Ephrin type-A receptor 7 precursor - Gallus gallus (Chicken)| Length = 993 Score = 73.6 bits (179), Expect = 2e-12 Identities = 59/238 (24%), Positives = 111/238 (46%), Gaps = 5/238 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PN+V L G V I +E D Sbjct: 657 VAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEYMENGALDA 716 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L +G +HRDL +N+L Sbjct: 717 FLRKHDGQFTVI----------------QLVGMLRGIAAGMRYLADMGYVHRDLAARNIL 760 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 ++ +L K+SD G+S+ +++D ++ G W APE ++ T A D++S G Sbjct: 761 VNS--NLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYG 818 Query: 585 CLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERP 752 +++ ++ G+ P+ + +D I I + L P +H + L Q + ERP Sbjct: 819 IVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERGERP 876
>P29320:EPHA3_HUMAN Ephrin type-A receptor 3 precursor - Homo sapiens (Human)| Length = 983 Score = 73.6 bits (179), Expect = 2e-12 Identities = 59/242 (24%), Positives = 108/242 (44%), Gaps = 3/242 (1%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PNI+RL G V I E D Sbjct: 650 VAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDS 709 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + +G+ +L +G +HRDL +N+L Sbjct: 710 FLRKHDAQFTVI----------------QLVGMLRGIASGMKYLSDMGYVHRDLAARNIL 753 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 I+ +L K+SD G+S+ L++D + G W +PE + T A D++S G Sbjct: 754 IN--SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYG 811 Query: 585 CLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMY 764 +++ ++ G+ P+ E +D V+ + E L P P + P A+Y Sbjct: 812 IVLWEVMSYGERPYWEMSNQD-----------VIKAVDEGYRL------PPPMDCPAALY 854 Query: 765 AI 770 + Sbjct: 855 QL 856
>O13146:EPHA3_DANRE Ephrin type-A receptor 3 precursor - Danio rerio (Zebrafish)| (Brachydanio rerio) Length = 981 Score = 73.6 bits (179), Expect = 2e-12 Identities = 52/203 (25%), Positives = 97/203 (47%), Gaps = 3/203 (1%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLAD 221 +VA+K L +++ +++ +++ PNI+RL G V I E D Sbjct: 654 QVAIKSLKAGYSEHQRRDFLSEASIMGQFDHPNIIRLEGVVTRCKPVMIVTEYMENGSLD 713 Query: 222 LIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 + D F+ + QLL ++R + AG+ +L + +HRDL +N+ Sbjct: 714 TFLKKHDGQFTVI----------------QLLGMLRGIAAGMQYLSEMNYVHRDLAARNI 757 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L+++ +L K+SD G+S+ L++D + G W APE + T A D++S Sbjct: 758 LVNR--NLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAITYRKFTSASDVWSY 815 Query: 582 GCLIFYCITKGKHPFGEYYERDI 650 G +++ I+ G+ P+ E +D+ Sbjct: 816 GIVMWEVISYGERPYWEMSNQDV 838
>Q7RZD3:STE20_NEUCR Serine/threonine-protein kinase ste-20 - Neurospora crassa| Length = 954 Score = 73.2 bits (178), Expect = 2e-12 Identities = 57/199 (28%), Positives = 93/199 (46%), Gaps = 1/199 (0%) Frame = +3 Query: 33 GSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFV-YISLERCHC 209 G Y G E RL+ I Q ++ D N + + N V +I C Sbjct: 687 GVYTGHERGSNRLVA----IKQMNLEQQPKKDLIINEILVMKESSHPNIVNFIDSYLCAG 742 Query: 210 SLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLK 389 L +++ S +DV ++ + Q+ + R+ + G+ HLHS G+IHRD+K Sbjct: 743 ELWVVMEYMEGGSLTDVVTFNI-------MTEGQIASVCRETLRGLQHLHSKGVIHRDIK 795 Query: 390 PQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMD 569 N+L+S EG++ KL+D G + E S + T G+ W APE + R R +D Sbjct: 796 SDNILLSMEGNI--KLTDFGFCATINEAQSKRT---TMVGTPYWMAPEVVTRKEYGRKVD 850 Query: 570 LFSLGCLIFYCITKGKHPF 626 ++SLG + I +G+ P+ Sbjct: 851 IWSLGIMAIEMI-EGEPPY 868
>Q5BBL3:STE20_EMENI Serine/threonine-protein kinase ste20 - Emericella nidulans| (Aspergillus nidulans) Length = 848 Score = 73.2 bits (178), Expect = 2e-12 Identities = 49/165 (29%), Positives = 86/165 (52%), Gaps = 4/165 (2%) Frame = +3 Query: 297 LPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDM 476 + PQ+ + R+ + G+ HLHS G+IHRD+K N+L+S +G++ KL+D G ++ + Sbjct: 658 MSEPQIAAVCRETLNGLQHLHSKGVIHRDIKSDNILLSLDGNI--KLTDFGFCAQIND-- 713 Query: 477 SSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-GEYYERDIN 653 S + T G+ W APE + R R +D++SLG + I +G+ P+ E R + Sbjct: 714 -SQNKRNTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMI-EGEPPYLTESPLRALY 771 Query: 654 IINGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 +I + + D P + L+ P++R +A + HP Sbjct: 772 LIATNGTPKIKDEHNLSPVFKDFLHFALRVDPEKRASAHDLLKHP 816
>O55173:PDPK1_RAT 3-phosphoinositide-dependent protein kinase 1 - Rattus norvegicus| (Rat) Length = 559 Score = 73.2 bits (178), Expect = 2e-12 Identities = 71/252 (28%), Positives = 118/252 (46%), Gaps = 10/252 (3%) Frame = +3 Query: 3 KGSNGTVVFEGSY-DGREVAVKRLLRSHTDIAQKEIQNLIASDRD-------PNIVRLYG 158 +GS TVV RE A+K L + H I ++ + +RD P V+LY Sbjct: 93 EGSFSTVVLARELATSREYAIKILEKRH--IIKENKVPYVTRERDVMSRLDHPFFVKLYF 150 Query: 159 CDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVV 338 QDD +Y L + +L++ ++ +T + +V Sbjct: 151 TFQDDEKLYFGLS--YAKNGELLKYIR--KIGSFDETCTRFYTAE-------------IV 193 Query: 339 AGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSG 518 + + +LH GIIHRDLKP+N+L++++ + +++D G +K L D S + + G++ Sbjct: 194 SALEYLHGKGIIHRDLKPENILLNED--MHIQITDFGTAKVLSPD-SKQARANSFVGTAQ 250 Query: 519 WQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF--GEYYERDINIINGHFDLFVVDH 692 + +PE L S ++ DL++LGC+I Y + G PF G Y II +D F Sbjct: 251 YVSPELLTEKSACKSSDLWALGCII-YQLVAGLPPFRAGNEYLIFQKIIKLEYD-FPEKF 308 Query: 693 IPEAVHLISLLL 728 P+A L+ LL Sbjct: 309 FPKARDLVEKLL 320
>P51954:NEK1_MOUSE Serine/threonine-protein kinase Nek1 - Mus musculus (Mouse)| Length = 1203 Score = 73.2 bits (178), Expect = 2e-12 Identities = 65/259 (25%), Positives = 122/259 (47%), Gaps = 8/259 (3%) Frame = +3 Query: 3 KGSNG-TVVFEGSYDGREVAVKRLLRSHTDIAQKEIQN------LIASDRDPNIVRLYGC 161 +GS G V+ + + DGR +K + S ++ KE Q ++A+ + PNIV+ Sbjct: 12 EGSFGKAVLVKSTEDGRHYVIKEINISR--MSDKERQESRREVAVLANMKHPNIVQYKES 69 Query: 162 DQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVA 341 +++ +YI ++ +C DL F + L+ +D Q+L + Sbjct: 70 FEENGSLYIVMD--YCEGGDL--------FKRINAQKGALFQED-----QILDWFVQICL 114 Query: 342 GIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGW 521 + H+H I+HRD+K QN+ ++K+G++ +L D GI++ L S++ T G+ + Sbjct: 115 ALKHVHDRKILHRDIKSQNIFLTKDGTV--QLGDFGIARVLN---STVELARTCIGTPYY 169 Query: 522 QAPEQLRRASQTRAMDLFSLGCLIF-YCITKGKHPFGEYYERDINIINGHFDLFVVDHIP 698 +PE D+++LGC+++ C K G + II+G F + Sbjct: 170 LSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSY 229 Query: 699 EAVHLISLLLQPKPDERPT 755 + L+S L + P +RP+ Sbjct: 230 DLRSLLSQLFKRNPRDRPS 248
>Q3MHJ9:KCC2B_BOVIN Calcium/calmodulin-dependent protein kinase type II beta chain -| Bos taurus (Bovine) Length = 542 Score = 73.2 bits (178), Expect = 2e-12 Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 6/158 (3%) Frame = +3 Query: 324 MRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGT 500 ++ ++ ++H H +G++HRDLKP+N+L+ SK + KL+D G++ +Q D + Sbjct: 117 IQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFA- 175 Query: 501 GYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NIINGHFD 674 G+ G+ +PE LR+ + + +D+++ G +I Y + G PF + + + I G +D Sbjct: 176 --GTPGYLSPEVLRKEAYGKPVDIWACG-VILYILLVGYPPFWDEDQHKLYQQIKAGAYD 232 Query: 675 LFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 + PEA +LI+ +L P +R A A+ HP Sbjct: 233 FPSPEWDTVTPEAKNLINQMLTINPAKRIMAHEALKHP 270
>P11275:KCC2A_RAT Calcium/calmodulin-dependent protein kinase type II alpha chain -| Rattus norvegicus (Rat) Length = 478 Score = 73.2 bits (178), Expect = 2e-12 Identities = 61/223 (27%), Positives = 107/223 (47%), Gaps = 6/223 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PNIVRL+ IS E H + DL+ F D+ ++ Sbjct: 68 KHPNIVRLHDS--------ISEEGHHYLIFDLVTG--GELFEDIV-------AREYYSEA 110 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSL 485 ++ ++ ++H H +G++HRDLKP+N+L+ SK + KL+D G++ ++ + + Sbjct: 111 DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAW 170 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NII 659 G+ G+ +PE LR+ + +DL++ G +I Y + G PF + + + I Sbjct: 171 FGFA---GTPGYLSPEVLRKDPYGKPVDLWACG-VILYILLVGYPPFWDEDQHRLYQQIK 226 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G +D + PEA LI+ +L P +R TA A+ HP Sbjct: 227 AGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHP 269
>Q5RCC4:KCC2A_PONPY Calcium/calmodulin-dependent protein kinase type II alpha chain -| Pongo pygmaeus (Orangutan) Length = 478 Score = 73.2 bits (178), Expect = 2e-12 Identities = 61/223 (27%), Positives = 107/223 (47%), Gaps = 6/223 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PNIVRL+ IS E H + DL+ F D+ ++ Sbjct: 68 KHPNIVRLHDS--------ISEEGHHYLIFDLVTG--GELFEDIV-------AREYYSEA 110 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSL 485 ++ ++ ++H H +G++HRDLKP+N+L+ SK + KL+D G++ ++ + + Sbjct: 111 DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAW 170 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NII 659 G+ G+ +PE LR+ + +DL++ G +I Y + G PF + + + I Sbjct: 171 FGFA---GTPGYLSPEVLRKDPYGKPVDLWACG-VILYILLVGYPPFWDEDQHRLYQQIK 226 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G +D + PEA LI+ +L P +R TA A+ HP Sbjct: 227 AGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHP 269
>P11798:KCC2A_MOUSE Calcium/calmodulin-dependent protein kinase type II alpha chain -| Mus musculus (Mouse) Length = 478 Score = 73.2 bits (178), Expect = 2e-12 Identities = 61/223 (27%), Positives = 107/223 (47%), Gaps = 6/223 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PNIVRL+ IS E H + DL+ F D+ ++ Sbjct: 68 KHPNIVRLHDS--------ISEEGHHYLIFDLVTG--GELFEDIV-------AREYYSEA 110 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSL 485 ++ ++ ++H H +G++HRDLKP+N+L+ SK + KL+D G++ ++ + + Sbjct: 111 DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAW 170 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NII 659 G+ G+ +PE LR+ + +DL++ G +I Y + G PF + + + I Sbjct: 171 FGFA---GTPGYLSPEVLRKDPYGKPVDLWACG-VILYILLVGYPPFWDEDQHRLYQQIK 226 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G +D + PEA LI+ +L P +R TA A+ HP Sbjct: 227 AGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHP 269
>Q9UQM7:KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II alpha chain -| Homo sapiens (Human) Length = 478 Score = 73.2 bits (178), Expect = 2e-12 Identities = 61/223 (27%), Positives = 107/223 (47%), Gaps = 6/223 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PNIVRL+ IS E H + DL+ F D+ ++ Sbjct: 68 KHPNIVRLHDS--------ISEEGHHYLIFDLVTG--GELFEDIV-------AREYYSEA 110 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSL 485 ++ ++ ++H H +G++HRDLKP+N+L+ SK + KL+D G++ ++ + + Sbjct: 111 DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAW 170 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NII 659 G+ G+ +PE LR+ + +DL++ G +I Y + G PF + + + I Sbjct: 171 FGFA---GTPGYLSPEVLRKDPYGKPVDLWACG-VILYILLVGYPPFWDEDQHRLYQQIK 226 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G +D + PEA LI+ +L P +R TA A+ HP Sbjct: 227 AGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHP 269
>O70150:KCC1B_RAT Calcium/calmodulin-dependent protein kinase type 1B - Rattus| norvegicus (Rat) Length = 343 Score = 73.2 bits (178), Expect = 2e-12 Identities = 73/247 (29%), Positives = 112/247 (45%), Gaps = 9/247 (3%) Frame = +3 Query: 63 KRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCS-LADLIQQHT 239 K+ LR + + EI ++ PNIV L + + +Y+++E L D I + Sbjct: 48 KKALRGKEALVENEIA-VLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERG 106 Query: 240 DPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEG 419 + D L+ V+ + +LHSLGI+HRDLKP+N+L + Sbjct: 107 SYTEKDASH------------------LVGQVLGAVSYLHSLGIVHRDLKPENLLYATPF 148 Query: 420 SLS-AKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIF 596 S +SD G+SK +M GT G+ G+ APE L + +A+D+++LG +I Sbjct: 149 EDSKIMVSDFGLSKIQAGNML-----GTACGTPGYVAPELLEQKPYGKAVDVWALG-VIS 202 Query: 597 YCITKGKHPFGEYYERDINIING------HFDLFVVDHIPE-AVHLISLLLQPKPDERPT 755 Y + G PF Y E D + + FD D I E A I LL+ P +R T Sbjct: 203 YILLCGYPPF--YDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFT 260 Query: 756 AMYAINH 776 A+ H Sbjct: 261 CQQALQH 267
>Q9QYK9:KCC1B_MOUSE Calcium/calmodulin-dependent protein kinase type 1B - Mus musculus| (Mouse) Length = 343 Score = 73.2 bits (178), Expect = 2e-12 Identities = 73/247 (29%), Positives = 112/247 (45%), Gaps = 9/247 (3%) Frame = +3 Query: 63 KRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCS-LADLIQQHT 239 K+ LR + + EI ++ PNIV L + + +Y+++E L D I + Sbjct: 48 KKALRGKEALVENEIA-VLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERG 106 Query: 240 DPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEG 419 + D L+ V+ + +LHSLGI+HRDLKP+N+L + Sbjct: 107 SYTEKDASH------------------LVGQVLGAVSYLHSLGIVHRDLKPENLLYATPF 148 Query: 420 SLS-AKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIF 596 S +SD G+SK +M GT G+ G+ APE L + +A+D+++LG +I Sbjct: 149 EDSKIMVSDFGLSKIQAGNML-----GTACGTPGYVAPELLEQKPYGKAVDVWALG-VIS 202 Query: 597 YCITKGKHPFGEYYERDINIING------HFDLFVVDHIPE-AVHLISLLLQPKPDERPT 755 Y + G PF Y E D + + FD D I E A I LL+ P +R T Sbjct: 203 YILLCGYPPF--YDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFT 260 Query: 756 AMYAINH 776 A+ H Sbjct: 261 CQQALQH 267
>Q6P2M8:KCC1B_HUMAN Calcium/calmodulin-dependent protein kinase type 1B - Homo sapiens| (Human) Length = 343 Score = 73.2 bits (178), Expect = 2e-12 Identities = 73/247 (29%), Positives = 112/247 (45%), Gaps = 9/247 (3%) Frame = +3 Query: 63 KRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCS-LADLIQQHT 239 K+ LR + + EI ++ PNIV L + + +Y+++E L D I + Sbjct: 48 KKALRGKEALVENEIA-VLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERG 106 Query: 240 DPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEG 419 + D L+ V+ + +LHSLGI+HRDLKP+N+L + Sbjct: 107 SYTEKDASH------------------LVGQVLGAVSYLHSLGIVHRDLKPENLLYATPF 148 Query: 420 SLS-AKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIF 596 S +SD G+SK +M GT G+ G+ APE L + +A+D+++LG +I Sbjct: 149 EDSKIMVSDFGLSKIQAGNML-----GTACGTPGYVAPELLEQKPYGKAVDVWALG-VIS 202 Query: 597 YCITKGKHPFGEYYERDINIING------HFDLFVVDHIPE-AVHLISLLLQPKPDERPT 755 Y + G PF Y E D + + FD D I E A I LL+ P +R T Sbjct: 203 YILLCGYPPF--YDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFT 260 Query: 756 AMYAINH 776 A+ H Sbjct: 261 CQQALRH 267
>Q63450:KCC1A_RAT Calcium/calmodulin-dependent protein kinase type 1 - Rattus| norvegicus (Rat) Length = 374 Score = 73.2 bits (178), Expect = 2e-12 Identities = 56/162 (34%), Positives = 85/162 (52%), Gaps = 8/162 (4%) Frame = +3 Query: 318 KLMRDVVAGIVHLHSLGIIHRDLKPQNVL-ISKEGSLSAKLSDMGISKRLQEDMSSLSHH 494 +L+ V+ + +LH LGI+HRDLKP+N+L S + +SD G+SK ED S+ Sbjct: 120 RLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSK--MEDPGSVL-- 175 Query: 495 GTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIING--- 665 T G+ G+ APE L + ++A+D +S+G +I Y + G PF Y E D + Sbjct: 176 STACGTPGYVAPEVLAQKPYSKAVDCWSIG-VIAYILLCGYPPF--YDENDAKLFEQILK 232 Query: 666 ---HFDLFVVDHIPE-AVHLISLLLQPKPDERPTAMYAINHP 779 FD D I + A I L++ P++R T A+ HP Sbjct: 233 AEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHP 274
>Q91YS8:KCC1A_MOUSE Calcium/calmodulin-dependent protein kinase type 1 - Mus musculus| (Mouse) Length = 374 Score = 73.2 bits (178), Expect = 2e-12 Identities = 56/162 (34%), Positives = 85/162 (52%), Gaps = 8/162 (4%) Frame = +3 Query: 318 KLMRDVVAGIVHLHSLGIIHRDLKPQNVL-ISKEGSLSAKLSDMGISKRLQEDMSSLSHH 494 +L+ V+ + +LH LGI+HRDLKP+N+L S + +SD G+SK ED S+ Sbjct: 120 RLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSK--MEDPGSVL-- 175 Query: 495 GTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIING--- 665 T G+ G+ APE L + ++A+D +S+G +I Y + G PF Y E D + Sbjct: 176 STACGTPGYVAPEVLAQKPYSKAVDCWSIG-VIAYILLCGYPPF--YDENDAKLFEQILK 232 Query: 666 ---HFDLFVVDHIPE-AVHLISLLLQPKPDERPTAMYAINHP 779 FD D I + A I L++ P++R T A+ HP Sbjct: 233 AEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHP 274
>Q14012:KCC1A_HUMAN Calcium/calmodulin-dependent protein kinase type 1 - Homo sapiens| (Human) Length = 370 Score = 73.2 bits (178), Expect = 2e-12 Identities = 56/162 (34%), Positives = 85/162 (52%), Gaps = 8/162 (4%) Frame = +3 Query: 318 KLMRDVVAGIVHLHSLGIIHRDLKPQNVL-ISKEGSLSAKLSDMGISKRLQEDMSSLSHH 494 +L+ V+ + +LH LGI+HRDLKP+N+L S + +SD G+SK ED S+ Sbjct: 120 RLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSK--MEDPGSVL-- 175 Query: 495 GTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIING--- 665 T G+ G+ APE L + ++A+D +S+G +I Y + G PF Y E D + Sbjct: 176 STACGTPGYVAPEVLAQKPYSKAVDCWSIG-VIAYILLCGYPPF--YDENDAKLFEQILK 232 Query: 666 ---HFDLFVVDHIPE-AVHLISLLLQPKPDERPTAMYAINHP 779 FD D I + A I L++ P++R T A+ HP Sbjct: 233 AEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHP 274
>Q12263:GIN4_YEAST Serine/threonine-protein kinase GIN4 - Saccharomyces cerevisiae| (Baker's yeast) Length = 1142 Score = 73.2 bits (178), Expect = 2e-12 Identities = 61/222 (27%), Positives = 109/222 (49%), Gaps = 6/222 (2%) Frame = +3 Query: 135 PNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQL 314 PN++RLY + + +Y+ LE +++ ++ L + LP + Sbjct: 91 PNVLRLYDVWETNTDLYLVLE-----------------YAEKGELFNLLVERGPLPEHEA 133 Query: 315 LKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHH 494 ++ R ++ G+ + H+LGI+HRDLKP+N+L+ + ++ K++D G++ L+ + L Sbjct: 134 IRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNI--KIADFGMA-ALETEGKLLE-- 188 Query: 495 GTGYGSSGWQAPEQLRRAS-QTRAMDLFSLGCLIFYCITKGKHPF----GEYYERDINII 659 T GS + APE + Q A D++S G ++F +T G+ PF G + + Sbjct: 189 -TSCGSPHYAAPEIVSGIPYQGFASDVWSCGVILFALLT-GRLPFDEEDGNIRTLLLKVQ 246 Query: 660 NGHFDLFVVDHIP-EAVHLISLLLQPKPDERPTAMYAINHPL 782 G F++ D I EA LI +L P+ R + HPL Sbjct: 247 KGEFEMPSDDEISREAQDLIRKILTVDPERRIKTRDILKHPL 288
>P54754:EPHB3_MOUSE Ephrin type-B receptor 3 precursor - Mus musculus (Mouse)| Length = 993 Score = 73.2 bits (178), Expect = 2e-12 Identities = 58/229 (25%), Positives = 108/229 (47%), Gaps = 6/229 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PNI+RL G V I E D Sbjct: 657 VAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDS 716 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 717 FLRLNDGQFTVI----------------QLVGMLRGIAAGMKYLSEMNYVHRDLAARNIL 760 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ L++D S ++ + G W APE + T A D++S Sbjct: 761 VN--SNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWS 818 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL 722 G +++ ++ G+ P+ + +D IN + + L P A+H + L Sbjct: 819 YGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLML 867
>P54753:EPHB3_HUMAN Ephrin type-B receptor 3 precursor - Homo sapiens (Human)| Length = 998 Score = 73.2 bits (178), Expect = 2e-12 Identities = 58/229 (25%), Positives = 108/229 (47%), Gaps = 6/229 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PNI+RL G V I E D Sbjct: 662 VAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDS 721 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 722 FLRLNDGQFTVI----------------QLVGMLRGIAAGMKYLSEMNYVHRDLAARNIL 765 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ L++D S ++ + G W APE + T A D++S Sbjct: 766 VN--SNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWS 823 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL 722 G +++ ++ G+ P+ + +D IN + + L P A+H + L Sbjct: 824 YGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLML 872
>Q91571:EPB1A_XENLA Ephrin type-B receptor 1-A precursor - Xenopus laevis (African clawed| frog) Length = 985 Score = 73.2 bits (178), Expect = 2e-12 Identities = 64/256 (25%), Positives = 116/256 (45%), Gaps = 9/256 (3%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +++ +++ +++ PNI+RL G V I E D Sbjct: 649 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDS 708 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 709 FLRQNDGQFTVI----------------QLVGMLRGIAAGMKYLSEMNYVHRDLAARNIL 752 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ LQ+D S ++ + G W A E + T A D++S Sbjct: 753 VN--SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAQEAIAYRKFTSASDVWS 810 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERP 752 G +++ ++ G+ P+ +D IN I + L P A+H + L Q + RP Sbjct: 811 YGIVMWEVMSYGERPYWTMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRP 870 Query: 753 TAMYAIN--HPLFWSP 794 +N P+ +P Sbjct: 871 RLAEIVNTLRPMIRNP 886
>Q6DFJ6:TBK1_XENLA Serine/threonine-protein kinase TBK1 - Xenopus laevis (African| clawed frog) Length = 725 Score = 72.8 bits (177), Expect = 3e-12 Identities = 56/190 (29%), Positives = 92/190 (48%), Gaps = 10/190 (5%) Frame = +3 Query: 87 DIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEK 266 D+ +E + ++ NIV+L+ +++ + + L C A L +P+ S Sbjct: 50 DVQMREFE-VLKKLNHKNIVKLFAIEEEMSSRHKVLVMEFCPCASLYSVLEEPTNSY--- 105 Query: 267 IDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL--ISKEGSLSAKLS 440 GLP + L + RDVVAG+ HL GIIHRD+KP N++ I ++G KL+ Sbjct: 106 ---------GLPESEFLIVSRDVVAGMNHLRENGIIHRDIKPGNIMREIGEDGKSVYKLT 156 Query: 441 DMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRA--------SQTRAMDLFSLGCLIF 596 D G ++ L++D +S YG+ + P+ RA + +DL+S+G + F Sbjct: 157 DFGAARELEDDEQFVSL----YGTEEYLHPDMYERAVLRKEHQKKYSATVDLWSIG-VTF 211 Query: 597 YCITKGKHPF 626 Y G PF Sbjct: 212 YHAATGSLPF 221
>A4K2S1:STK4_LEMCA Serine/threonine-protein kinase 4 - Lemur catta (Ring-tailed lemur)| Length = 487 Score = 72.8 bits (177), Expect = 3e-12 Identities = 64/258 (24%), Positives = 118/258 (45%), Gaps = 13/258 (5%) Frame = +3 Query: 45 GREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLAD 221 G+ VA+K++ + S KEI + D P++V+ YG + ++I +E C Sbjct: 53 GQIVAIKQVPVESDLQEIIKEISIMQQCD-SPHVVKYYGSYFKNTDLWIVMEYCGAG--- 108 Query: 222 LIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 S SD+ ++ + T+D ++ +++ + G+ +LH + IHRD+K N+ Sbjct: 109 --------SVSDIIRLRNKTLTED-----EIATILQSTLKGLEYLHFMRKIHRDIKAGNI 155 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L++ EG AKL+D G++ +L + M+ T G+ W APE ++ D++SL Sbjct: 156 LLNTEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEVIQEIGYNCVADIWSL 210 Query: 582 GCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------------EAVHLISLL 725 G + +GK P+ + I+ +F++ P + + Sbjct: 211 GITAIE-MAEGKPPYAD--------IHPMRAIFMIPTNPPPTFRKPELWSDNFMDFVRQC 261 Query: 726 LQPKPDERPTAMYAINHP 779 L PD+R TA + HP Sbjct: 262 LVKSPDQRATATQLLQHP 279
>Q63531:KS6A1_RAT Ribosomal protein S6 kinase alpha-1 - Rattus norvegicus (Rat)| Length = 735 Score = 72.8 bits (177), Expect = 3e-12 Identities = 57/195 (29%), Positives = 96/195 (49%), Gaps = 3/195 (1%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQ 230 +V K L+ + K ++++A P +V+L+ Q + +Y+ L+ DL Sbjct: 94 KVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGG--DLFT 151 Query: 231 QHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLIS 410 + + E DV+ + + ++ G+ HLHSLGII+RDLKP+N+L+ Sbjct: 152 RLSKEVMFTEE--DVKFY-------------LAELALGLDHLHSLGIIYRDLKPENILLD 196 Query: 411 KEGSLSAKLSDMGISKRLQEDMSSLSHHGTGY---GSSGWQAPEQLRRASQTRAMDLFSL 581 +EG + KL+D G+SK ++ H Y G+ + APE + R T + D +S Sbjct: 197 EEGHI--KLTDFGLSK------EAIDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSY 248 Query: 582 GCLIFYCITKGKHPF 626 G L+F +T G PF Sbjct: 249 GVLMFEMLT-GSLPF 262 Score = 67.8 bits (164), Expect = 1e-10 Identities = 69/253 (27%), Positives = 112/253 (44%), Gaps = 10/253 (3%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQ 230 E AVK + +S D ++ EI+ L+ + PNI+ L D VY+ E +L+ Sbjct: 443 EYAVKVIDKSKRDPSE-EIEILLRYGQHPNIITLKDVYDDSKHVYLVTELMRGG--ELLD 499 Query: 231 QHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL-I 407 + F + L+T + + +LHS G++HRDLKP N+L + Sbjct: 500 KILRQKFFSEREASFVLYT---------------ISKTVEYLHSQGVVHRDLKPSNILYV 544 Query: 408 SKEGSLSA-KLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 + G+ ++ D G +K+L+ + L T ++ + APE L+R D++SLG Sbjct: 545 DESGNPECLRICDFGFAKQLRAENGLLM---TPCYTANFVAPEVLKRQGYDEGCDIWSLG 601 Query: 585 CLIFYCITKGKHPFGE-----YYERDINIINGHFDLFVVDH---IPEAVHLISLLLQPKP 740 L+ Y + G PF E I +G F L + A L+S +L P Sbjct: 602 VLL-YTMLAGYTPFANGPSDTPEEILTRISSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 660 Query: 741 DERPTAMYAINHP 779 +R TA + HP Sbjct: 661 HQRLTAKQVLQHP 673
>P15791:KCC2D_RAT Calcium/calmodulin-dependent protein kinase type II delta chain -| Rattus norvegicus (Rat) Length = 533 Score = 72.8 bits (177), Expect = 3e-12 Identities = 61/223 (27%), Positives = 106/223 (47%), Gaps = 6/223 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PNIVRL+ ++ F Y+ + DL+ F D+ ++ Sbjct: 69 KHPNIVRLHDSISEEGFHYL--------VFDLVTG--GELFEDIV-------AREYYSEA 111 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSL 485 ++ ++ + H H GI+HRDLKP+N+L+ SK + KL+D G++ +Q D + Sbjct: 112 DASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAW 171 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NII 659 G+ G+ +PE LR+ + +D+++ G +I Y + G PF + + + I Sbjct: 172 FGFA---GTPGYLSPEVLRKDPYGKPVDMWACG-VILYILLVGYPPFWDEDQHRLYQQIK 227 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G +D + PEA LI+ +L P +R TA A+ HP Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
>O77708:KCC2D_RABIT Calcium/calmodulin-dependent protein kinase type II delta chain -| Oryctolagus cuniculus (Rabbit) Length = 533 Score = 72.8 bits (177), Expect = 3e-12 Identities = 61/223 (27%), Positives = 106/223 (47%), Gaps = 6/223 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PNIVRL+ ++ F Y+ + DL+ F D+ ++ Sbjct: 69 KHPNIVRLHDSISEEGFHYL--------VFDLVTG--GELFEDIV-------AREYYSEA 111 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSL 485 ++ ++ + H H GI+HRDLKP+N+L+ SK + KL+D G++ +Q D + Sbjct: 112 DASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAW 171 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NII 659 G+ G+ +PE LR+ + +D+++ G +I Y + G PF + + + I Sbjct: 172 FGFA---GTPGYLSPEVLRKDPYGKPVDMWACG-VILYILLVGYPPFWDEDQHRLYQQIK 227 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G +D + PEA LI+ +L P +R TA A+ HP Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
>Q95266:KCC2D_PIG Calcium/calmodulin-dependent protein kinase type II delta chain -| Sus scrofa (Pig) Length = 499 Score = 72.8 bits (177), Expect = 3e-12 Identities = 61/223 (27%), Positives = 106/223 (47%), Gaps = 6/223 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PNIVRL+ ++ F Y+ + DL+ F D+ ++ Sbjct: 69 KHPNIVRLHDSISEEGFHYL--------VFDLVTG--GELFEDIV-------AREYYSEA 111 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSL 485 ++ ++ + H H GI+HRDLKP+N+L+ SK + KL+D G++ +Q D + Sbjct: 112 DASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAW 171 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NII 659 G+ G+ +PE LR+ + +D+++ G +I Y + G PF + + + I Sbjct: 172 FGFA---GTPGYLSPEVLRKDPYGKPVDMWACG-VILYILLVGYPPFWDEDQHRLYQQIK 227 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G +D + PEA LI+ +L P +R TA A+ HP Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
>Q6PHZ2:KCC2D_MOUSE Calcium/calmodulin-dependent protein kinase type II delta chain -| Mus musculus (Mouse) Length = 499 Score = 72.8 bits (177), Expect = 3e-12 Identities = 61/223 (27%), Positives = 106/223 (47%), Gaps = 6/223 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PNIVRL+ ++ F Y+ + DL+ F D+ ++ Sbjct: 69 KHPNIVRLHDSISEEGFHYL--------VFDLVTG--GELFEDIV-------AREYYSEA 111 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSL 485 ++ ++ + H H GI+HRDLKP+N+L+ SK + KL+D G++ +Q D + Sbjct: 112 DASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAW 171 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NII 659 G+ G+ +PE LR+ + +D+++ G +I Y + G PF + + + I Sbjct: 172 FGFA---GTPGYLSPEVLRKDPYGKPVDMWACG-VILYILLVGYPPFWDEDQHRLYQQIK 227 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G +D + PEA LI+ +L P +R TA A+ HP Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
>Q13557:KCC2D_HUMAN Calcium/calmodulin-dependent protein kinase type II delta chain -| Homo sapiens (Human) Length = 499 Score = 72.8 bits (177), Expect = 3e-12 Identities = 61/223 (27%), Positives = 106/223 (47%), Gaps = 6/223 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PNIVRL+ ++ F Y+ + DL+ F D+ ++ Sbjct: 69 KHPNIVRLHDSISEEGFHYL--------VFDLVTG--GELFEDIV-------AREYYSEA 111 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSL 485 ++ ++ + H H GI+HRDLKP+N+L+ SK + KL+D G++ +Q D + Sbjct: 112 DASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAW 171 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NII 659 G+ G+ +PE LR+ + +D+++ G +I Y + G PF + + + I Sbjct: 172 FGFA---GTPGYLSPEVLRKDPYGKPVDMWACG-VILYILLVGYPPFWDEDQHRLYQQIK 227 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G +D + PEA LI+ +L P +R TA A+ HP Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
>Q2HJF7:KCC2D_BOVIN Calcium/calmodulin-dependent protein kinase type II delta chain -| Bos taurus (Bovine) Length = 488 Score = 72.8 bits (177), Expect = 3e-12 Identities = 61/223 (27%), Positives = 106/223 (47%), Gaps = 6/223 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PNIVRL+ ++ F Y+ + DL+ F D+ ++ Sbjct: 69 KHPNIVRLHDSISEEGFHYL--------VFDLVTG--GELFEDIV-------AREYYSEA 111 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSL 485 ++ ++ + H H GI+HRDLKP+N+L+ SK + KL+D G++ +Q D + Sbjct: 112 DASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAW 171 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NII 659 G+ G+ +PE LR+ + +D+++ G +I Y + G PF + + + I Sbjct: 172 FGFA---GTPGYLSPEVLRKDPYGKPVDMWACG-VILYILLVGYPPFWDEDQHRLYQQIK 227 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G +D + PEA LI+ +L P +R TA A+ HP Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
>P54759:EPHA7_RAT Ephrin type-A receptor 7 precursor - Rattus norvegicus (Rat)| Length = 998 Score = 72.8 bits (177), Expect = 3e-12 Identities = 59/238 (24%), Positives = 111/238 (46%), Gaps = 5/238 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PN+V L G V I +E D Sbjct: 662 VAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDA 721 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L +G +HRDL +N+L Sbjct: 722 FLRKHDGQFTVI----------------QLVGMLRGIAAGMRYLADMGYVHRDLAARNIL 765 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 ++ +L K+SD G+S+ +++D ++ G W APE ++ T A D++S G Sbjct: 766 VNS--NLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYG 823 Query: 585 CLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERP 752 +++ ++ G+ P+ + +D I I + L P +H + L Q + ERP Sbjct: 824 IVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERP 881
>Q15375:EPHA7_HUMAN Ephrin type-A receptor 7 precursor - Homo sapiens (Human)| Length = 998 Score = 72.8 bits (177), Expect = 3e-12 Identities = 59/238 (24%), Positives = 111/238 (46%), Gaps = 5/238 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PN+V L G V I +E D Sbjct: 662 VAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDA 721 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L +G +HRDL +N+L Sbjct: 722 FLRKHDGQFTVI----------------QLVGMLRGIAAGMRYLADMGYVHRDLAARNIL 765 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 ++ +L K+SD G+S+ +++D ++ G W APE ++ T A D++S G Sbjct: 766 VNS--NLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYG 823 Query: 585 CLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERP 752 +++ ++ G+ P+ + +D I I + L P +H + L Q + ERP Sbjct: 824 IVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERP 881
>P38147:CHK1_YEAST Serine/threonine-protein kinase CHK1 - Saccharomyces cerevisiae| (Baker's yeast) Length = 527 Score = 72.8 bits (177), Expect = 3e-12 Identities = 69/252 (27%), Positives = 116/252 (46%), Gaps = 13/252 (5%) Frame = +3 Query: 63 KRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTD 242 K++ S DI KE+ + PN++RL C+ +++I LE DL Sbjct: 53 KKMGLSDKDIT-KEVVLQSKCSKHPNVLRLIDCNVSKEYMWIILEMADGG--DLF----- 104 Query: 243 PSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLH-SLGIIHRDLKPQNVLISKEG 419 +KI+ ++ G+ S + +V+ I +LH G+ HRD+KP+N+L+ K G Sbjct: 105 ------DKIEPDV----GVDSDVAQFYFQQLVSAINYLHVECGVAHRDIKPENILLDKNG 154 Query: 420 SLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQL--RRASQTRAMDLFSLGCLI 593 +L KL+D G++ + + +L GS + APE L D++S+G L+ Sbjct: 155 NL--KLADFGLASQFRRKDGTLRVSMDQRGSPPYMAPEVLYSEEGYYADRTDIWSIGILL 212 Query: 594 FYCITKGKHP----------FGEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPKPD 743 F +T G+ P F + E D N+ G + H+ +L+ +LQP P+ Sbjct: 213 FVLLT-GQTPWELPSLENEDFVFFIENDGNLNWGPWSKIEFTHL----NLLRKILQPDPN 267 Query: 744 ERPTAMYAINHP 779 +R T HP Sbjct: 268 KRVTLKALKLHP 279
>Q802A6:STK4_SQUAC Serine/threonine-protein kinase 3/4 - Squalus acanthias (Spiny| dogfish) Length = 491 Score = 72.4 bits (176), Expect = 4e-12 Identities = 69/274 (25%), Positives = 126/274 (45%), Gaps = 15/274 (5%) Frame = +3 Query: 3 KGSNGTVVFEGSY--DGREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDD 173 +GS G+V F+ + G+ VA+K++ + S KEI + D P++V+ YG + Sbjct: 40 EGSYGSV-FKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCD-SPHVVKYYGSYFKN 97 Query: 174 NFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVH 353 ++I +E C S SD+ +I + T+D ++ +++ + G+ + Sbjct: 98 TDLWIVMEYCGAG-----------SVSDLIRIRNKTLTED-----EIATILQSTLKGLEY 141 Query: 354 LHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPE 533 LH + IHRD+K N+L++ EG AKL+D G++ +L + M+ T G+ W APE Sbjct: 142 LHFMRKIHRDIKAGNILLNNEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPE 196 Query: 534 QLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP----- 698 ++ D++SLG + +GK P+ + I+ +F++ P Sbjct: 197 VIQEIGYNCVADIWSLGISAIE-MAEGKPPYAD--------IHPMRAIFMIPTNPPPTFR 247 Query: 699 -------EAVHLISLLLQPKPDERPTAMYAINHP 779 E + L P++R A + HP Sbjct: 248 KPELWTDEFTDFVKQCLVKNPEQRAAATQLLQHP 281
>A4K2Q5:STK4_OTOGA Serine/threonine-protein kinase 4 - Otolemur garnettii (Small-eared| galago) (Garnett's greater bushbaby) Length = 487 Score = 72.4 bits (176), Expect = 4e-12 Identities = 64/258 (24%), Positives = 117/258 (45%), Gaps = 13/258 (5%) Frame = +3 Query: 45 GREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLAD 221 G+ VA+K++ + S KEI + D P++V+ YG + ++I +E C Sbjct: 53 GQIVAIKQVPVESDLQEIIKEISIMQQCD-SPHVVKYYGSYFKNTDLWIVMEYCGAG--- 108 Query: 222 LIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 S SD+ ++ + T+D ++ +++ + G+ +LH + IHRD+K N+ Sbjct: 109 --------SVSDIIRLRNKTLTED-----EIATILQSTLKGLEYLHFMRKIHRDIKAGNI 155 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L++ EG AKL+D G++ +L + M+ T G+ W APE ++ D++SL Sbjct: 156 LLNTEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEVIQEIGYNCVADIWSL 210 Query: 582 GCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------------EAVHLISLL 725 G + +GK P+ + I+ +F++ P + Sbjct: 211 GITAIE-MAEGKPPYAD--------IHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVRQC 261 Query: 726 LQPKPDERPTAMYAINHP 779 L PD+R TA + HP Sbjct: 262 LVKSPDQRATATQLLQHP 279
>O54748:STK3_RAT Serine/threonine-protein kinase 3 - Rattus norvegicus (Rat)| Length = 491 Score = 72.4 bits (176), Expect = 4e-12 Identities = 68/274 (24%), Positives = 127/274 (46%), Gaps = 15/274 (5%) Frame = +3 Query: 3 KGSNGTVVFEGSY--DGREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDD 173 +GS G+V F+ + G+ VA+K++ + S KEI + D P +V+ YG + Sbjct: 35 EGSYGSV-FKAIHKESGQVVAIKQVPVESDVQEIIKEISIMQQCD-SPYVVKYYGSYFKN 92 Query: 174 NFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVH 353 ++I +E C S SD+ ++ + T+D ++ +++ + G+ + Sbjct: 93 TDLWIVMEYCGAG-----------SVSDIIRLRNKTLTED-----EIATILKSTLKGLEY 136 Query: 354 LHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPE 533 LH + IHRD+K N+L++ EG AKL+D G++ +L + M+ T G+ W APE Sbjct: 137 LHFMRKIHRDIKAGNILLNTEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPE 191 Query: 534 QLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP----- 698 ++ D++SLG + + +GK P+ + I+ +F++ P Sbjct: 192 VIQEIGYNCVADIWSLG-ITSIEMAEGKPPYAD--------IHPMRAIFMIPTNPPPTFR 242 Query: 699 -------EAVHLISLLLQPKPDERPTAMYAINHP 779 + + L P++R TA + HP Sbjct: 243 KPELWSDDFTDFVKKCLVKSPEQRATATQLLQHP 276
>Q7ZUQ3:STK3_DANRE Serine/threonine-protein kinase 3 - Danio rerio (Zebrafish)| (Brachydanio rerio) Length = 492 Score = 72.4 bits (176), Expect = 4e-12 Identities = 70/266 (26%), Positives = 128/266 (48%), Gaps = 7/266 (2%) Frame = +3 Query: 3 KGSNGTVVFEGSY--DGREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDD 173 +GS G+V F+ + G+ VA+K++ + S KEI + D P +V+ YG + Sbjct: 34 EGSYGSV-FKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCD-SPYVVKYYGSYFKN 91 Query: 174 NFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVH 353 ++I +E C S SD+ ++ + T+D ++ +++ + G+ + Sbjct: 92 TDLWIVMEYCGAG-----------SVSDIIRLRNKTLTED-----EIATVLKSTLKGLEY 135 Query: 354 LHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPE 533 LH + IHRD+K N+L++ EG AKL+D G++ +L + M+ T G+ W APE Sbjct: 136 LHFMRKIHRDIKAGNILLNTEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPE 190 Query: 534 QLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYE-RDINII--NGHFDLFVVDH-IPE 701 ++ D++SLG + + +GK P+ + + R I +I N +H + Sbjct: 191 VIQEIGYNCVADIWSLG-ITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEHWSDD 249 Query: 702 AVHLISLLLQPKPDERPTAMYAINHP 779 + L P++R TA + HP Sbjct: 250 FTDFVKKCLVKNPEQRATATQLLQHP 275
>Q2VWQ3:STE20_PENMA Serine/threonine-protein kinase pakA - Penicillium marneffei| Length = 642 Score = 72.4 bits (176), Expect = 4e-12 Identities = 49/161 (30%), Positives = 85/161 (52%), Gaps = 4/161 (2%) Frame = +3 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLS 488 Q+ + R+ ++G+ HLHS G+IHRD+K N+L+S +G + KL+D G ++ + S + Sbjct: 456 QIAAVCRETLSGLQHLHSKGVIHRDIKSDNILLSMDGEI--KLTDFGFCAQIND---SQN 510 Query: 489 HHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-GEYYERDINIING 665 T G+ W APE + R R +D++SLG + I +G+ P+ E R + +I Sbjct: 511 KRNTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMI-EGEPPYLTESPLRALYLIAT 569 Query: 666 HFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 + + D P + L L+ P++R +A + HP Sbjct: 570 NGTPKIKDEQNLSPVFRDFLHLALRVDPEKRASAHDLLKHP 610
>Q9FJV0:M2K6_ARATH Mitogen-activated protein kinase kinase 6 - Arabidopsis thaliana| (Mouse-ear cress) Length = 356 Score = 72.4 bits (176), Expect = 4e-12 Identities = 71/276 (25%), Positives = 127/276 (46%), Gaps = 17/276 (6%) Frame = +3 Query: 3 KGSNGTV-VFEGSYDGREVAVKRLLRSHTDIAQKEIQNLI----ASDRDPNIVRLYGCDQ 167 KGS G V + + G+ A+K + + + +K+I + AS + P++V Y Sbjct: 78 KGSGGVVQLVRHKWVGKFFAMKVIQMNIQEEIRKQIVQELKINQASSQCPHVVVCYHSFY 137 Query: 168 DDNFVYISLERC-HCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAG 344 + + LE SLAD+I+Q + P L + + V+ G Sbjct: 138 HNGAFSLVLEYMDRGSLADVIRQVKT------------------ILEPYLAVVCKQVLLG 179 Query: 345 IVHLHS-LGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGW 521 +V+LH+ +IHRD+KP N+L++ +G + K+SD G+S L SS+ T G+ + Sbjct: 180 LVYLHNERHVIHRDIKPSNLLVNHKGEV--KISDFGVSASL---ASSMGQRDTFVGTYNY 234 Query: 522 QAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGE---------YYERDINIINGHFD 674 +PE++ ++ + D++SLG + C G+ P+ E +YE I+ Sbjct: 235 MSPERISGSTYDYSSDIWSLGMSVLECAI-GRFPYLESEDQQNPPSFYELLAAIVENPPP 293 Query: 675 LFVVDHI-PEAVHLISLLLQPKPDERPTAMYAINHP 779 D PE +S +Q P R +++ ++HP Sbjct: 294 TAPSDQFSPEFCSFVSACIQKDPPARASSLDLLSHP 329
>P10665:KS6AA_XENLA Ribosomal protein S6 kinase 2 alpha - Xenopus laevis (African| clawed frog) Length = 733 Score = 72.4 bits (176), Expect = 4e-12 Identities = 57/195 (29%), Positives = 96/195 (49%), Gaps = 3/195 (1%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQ 230 +V K L+ + K ++++A P +VRL+ Q + +Y+ L+ DL Sbjct: 94 KVLKKATLKVRDRVRTKMERDILADVHHPFVVRLHYAFQTEGKLYLILDFLRGG--DLFT 151 Query: 231 QHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLIS 410 + + E DV+ + + ++ G+ HLHSLGII+RDLKP+N+L+ Sbjct: 152 RLSKEVMFTEE--DVKFY-------------LAELALGLDHLHSLGIIYRDLKPENILLD 196 Query: 411 KEGSLSAKLSDMGISKRLQEDMSSLSHHGTGY---GSSGWQAPEQLRRASQTRAMDLFSL 581 +EG + KL+D G+SK ++ H Y G+ + APE + R + + D +S Sbjct: 197 EEGHI--KLTDFGLSK------EAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSY 248 Query: 582 GCLIFYCITKGKHPF 626 G L+F +T G PF Sbjct: 249 GVLMFEMLT-GSLPF 262 Score = 65.1 bits (157), Expect = 6e-10 Identities = 70/252 (27%), Positives = 113/252 (44%), Gaps = 10/252 (3%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQ 230 E AVK + ++ D ++ EI+ L + PNI+ L ++ N +Y+ E +L+ Sbjct: 441 EYAVKVIDKTKRDPSE-EIEILRRYGQHPNIIALKDVYKEGNSIYVVTELMRGG--ELLD 497 Query: 231 QHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLIS 410 + F + L+T V + +LHS G++HRDLKP N+L Sbjct: 498 RILRQKFFSEREASSVLFT---------------VCKTVENLHSQGVVHRDLKPSNILYV 542 Query: 411 KEGS--LSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 E S ++ D G +K+L+ D L T ++ + APE L+R D++SLG Sbjct: 543 DESGDPESIRICDFGFAKQLRADNGLLM---TPCYTANFVAPEVLKRQGYDEGCDIWSLG 599 Query: 585 CLIFYCITKGKHPF----GEYYERDI-NIINGHFDLFVVDH---IPEAVHLISLLLQPKP 740 L+ Y + G PF G+ E + I +G F L + A L+S +L P Sbjct: 600 ILL-YTMLAGYTPFANGLGDTPEEILARIGSGKFTLRGGNWNTVSAAAKDLVSRMLHVDP 658 Query: 741 DERPTAMYAINH 776 +R TA + H Sbjct: 659 HKRLTAKQVLQH 670
>P18654:KS6A3_MOUSE Ribosomal protein S6 kinase alpha-3 - Mus musculus (Mouse)| Length = 740 Score = 72.4 bits (176), Expect = 4e-12 Identities = 70/253 (27%), Positives = 112/253 (44%), Gaps = 10/253 (3%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQ 230 E AVK + +S D + EI+ L+ + PNI+ L D +VY+ E +L+ Sbjct: 447 EFAVKIIDKSKRDPTE-EIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGG--ELLD 503 Query: 231 QHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLIS 410 + F + L+T + + +LH+ G++HRDLKP N+L Sbjct: 504 KILRQKFFSEREASAVLFT---------------ITKTVEYLHAQGVVHRDLKPSNILYV 548 Query: 411 KEGS--LSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 E S ++ D G +K+L+ + L T ++ + APE L+R A D++SLG Sbjct: 549 DESGNPESIRICDFGFAKQLRAENGLLM---TPCYTANFVAPEVLKRQGYDAACDIWSLG 605 Query: 585 CLIFYCITKGKHPFGE-----YYERDINIINGHFDL---FVVDHIPEAVHLISLLLQPKP 740 L++ +T G PF E I +G F L + A L+S +L P Sbjct: 606 VLLYTMLT-GYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDP 664 Query: 741 DERPTAMYAINHP 779 +R TA + HP Sbjct: 665 HQRLTAALVLRHP 677 Score = 72.0 bits (175), Expect = 5e-12 Identities = 49/146 (33%), Positives = 78/146 (53%), Gaps = 4/146 (2%) Frame = +3 Query: 324 MRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTG 503 + ++ + HLHSLGII+RDLKP+N+L+ +EG + KL+D G+SK S+ H Sbjct: 174 LAELALALDHLHSLGIIYRDLKPENILLDEEGHI--KLTDFGLSK------ESIDHEKKA 225 Query: 504 Y---GSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFD 674 Y G+ + APE + R T++ D +S G L+F +T G PF ++ + Sbjct: 226 YSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT-GTLPFQGKDRKETMTMILKAK 284 Query: 675 LFVVDHI-PEAVHLISLLLQPKPDER 749 L + + PEA L+ +L + P R Sbjct: 285 LGMPQFLSPEAQSLLRMLFKRNPANR 310
>P51812:KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 - Homo sapiens (Human)| Length = 740 Score = 72.4 bits (176), Expect = 4e-12 Identities = 70/253 (27%), Positives = 112/253 (44%), Gaps = 10/253 (3%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQ 230 E AVK + +S D + EI+ L+ + PNI+ L D +VY+ E +L+ Sbjct: 447 EFAVKIIDKSKRDPTE-EIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGG--ELLD 503 Query: 231 QHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLIS 410 + F + L+T + + +LH+ G++HRDLKP N+L Sbjct: 504 KILRQKFFSEREASAVLFT---------------ITKTVEYLHAQGVVHRDLKPSNILYV 548 Query: 411 KEGS--LSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 E S ++ D G +K+L+ + L T ++ + APE L+R A D++SLG Sbjct: 549 DESGNPESIRICDFGFAKQLRAENGLLM---TPCYTANFVAPEVLKRQGYDAACDIWSLG 605 Query: 585 CLIFYCITKGKHPFGE-----YYERDINIINGHFDL---FVVDHIPEAVHLISLLLQPKP 740 L++ +T G PF E I +G F L + A L+S +L P Sbjct: 606 VLLYTMLT-GYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDP 664 Query: 741 DERPTAMYAINHP 779 +R TA + HP Sbjct: 665 HQRLTAALVLRHP 677 Score = 72.0 bits (175), Expect = 5e-12 Identities = 49/146 (33%), Positives = 78/146 (53%), Gaps = 4/146 (2%) Frame = +3 Query: 324 MRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTG 503 + ++ + HLHSLGII+RDLKP+N+L+ +EG + KL+D G+SK S+ H Sbjct: 174 LAELALALDHLHSLGIIYRDLKPENILLDEEGHI--KLTDFGLSK------ESIDHEKKA 225 Query: 504 Y---GSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFD 674 Y G+ + APE + R T++ D +S G L+F +T G PF ++ + Sbjct: 226 YSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT-GTLPFQGKDRKETMTMILKAK 284 Query: 675 LFVVDHI-PEAVHLISLLLQPKPDER 749 L + + PEA L+ +L + P R Sbjct: 285 LGMPQFLSPEAQSLLRMLFKRNPANR 310
>O94806:KPCD3_HUMAN Serine/threonine-protein kinase D3 - Homo sapiens (Human)| Length = 890 Score = 72.4 bits (176), Expect = 4e-12 Identities = 75/286 (26%), Positives = 135/286 (47%), Gaps = 14/286 (4%) Frame = +3 Query: 21 VVFEGSY--DGREVAVKRLLRSHTDIAQK-EIQNLIASDRD---PNIVRLYGCDQDDNFV 182 +V+ G + GR+VA+K + + Q+ +++N +A ++ P IV L + V Sbjct: 589 IVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERV 648 Query: 183 YISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHS 362 ++ +E+ H + ++I + LP ++ ++ + +LH Sbjct: 649 FVVMEKLHGDMLEMILSSE----------------KSRLPERITKFMVTQILVALRNLHF 692 Query: 363 LGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQL 539 I+H DLKP+NVL+ S E KL D G ++ + E S + G+ + APE L Sbjct: 693 KNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEK----SFRRSVVGTPAYLAPEVL 748 Query: 540 RRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------E 701 R R++D++S+G +I+ ++ G PF E + + I N F+ P E Sbjct: 749 RSKGYNRSLDMWSVGVIIYVSLS-GTFPFNEDEDINDQIQNA---AFMYPPNPWREISGE 804 Query: 702 AVHLISLLLQPKPDERPTAMYAINHPLFWSPELRL-LFLRDTSDRI 836 A+ LI+ LLQ K +R + +++HP W + + L LR+ RI Sbjct: 805 AIDLINNLLQVKMRKRYSVDKSLSHP--WLQDYQTWLDLREFETRI 848
>P29318:EPHA3_CHICK Ephrin type-A receptor 3 precursor - Gallus gallus (Chicken)| Length = 983 Score = 72.4 bits (176), Expect = 4e-12 Identities = 59/242 (24%), Positives = 107/242 (44%), Gaps = 3/242 (1%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PNI+RL G V I E D Sbjct: 650 VAIKTLKAGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDS 709 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + +G+ +L +G +HRDL +N+L Sbjct: 710 FLRKHDAQFTVI----------------QLVGMLRGIASGMKYLSDMGYVHRDLAARNIL 753 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 I+ +L K+SD G+S+ L++D + G W +PE + T A D +S G Sbjct: 754 IN--SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDAWSYG 811 Query: 585 CLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMY 764 +++ ++ G+ P+ E +D V+ + E L P P + P A+Y Sbjct: 812 IVLWEVMSYGERPYWEMSFQD-----------VIKAVDEGYRL------PPPMDCPAALY 854 Query: 765 AI 770 + Sbjct: 855 QL 856
>Q8TFN2:ATG1_PICAN Serine/threonine-protein kinase ATG1 - Pichia angusta (Yeast)| (Hansenula polymorpha) Length = 804 Score = 72.4 bits (176), Expect = 4e-12 Identities = 85/293 (29%), Positives = 130/293 (44%), Gaps = 40/293 (13%) Frame = +3 Query: 24 VFEGSYDGRE---VAVKRLLRSHTDIAQKEIQNL------IASDRDPNIVRLYGCDQDDN 176 V++G YD R VAVK + RS QK ++NL + + ++P+IV L C + D Sbjct: 26 VYKG-YDNRTKAPVAVKSVFRSRLK-NQKLVENLEIEISILKNLKNPHIVALLDCVKTDQ 83 Query: 177 FVYISLERCHCSLADL----------IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLM 326 + ++ +E +CSL DL +Q H P S + + GL ++ + Sbjct: 84 YFHLFME--YCSLGDLSYFIRRRDQLVQTH--PLISSILERYPSPPNSHGLNKVLVVNFL 139 Query: 327 RDVVAGIVHLHSLGIIHRDLKPQNVLIS---------KEGSLSA-------KLSDMGISK 458 + + + + L ++HRD+KPQN+L+S K S K++D G ++ Sbjct: 140 KQLASALEFLRDQNLVHRDIKPQNLLLSPPVHSKEEFKRKGYSGLWELPVLKIADFGFAR 199 Query: 459 RLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF--GE 632 L S S T GS + APE LR DL+S+G +I Y ++ GK PF Sbjct: 200 FL----PSTSMAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVI-YEMSVGKPPFRASN 254 Query: 633 YYE--RDINIINGHFDLFVVDHIP-EAVHLISLLLQPKPDERPTAMYAINHPL 782 + E R I V +P + V LI LL+ P ER N PL Sbjct: 255 HVELLRKIEKSKDEITFPVSAEVPDDLVRLICGLLKANPTERMGFQEFFNDPL 307
>Q9JI10:STK3_MOUSE Serine/threonine-protein kinase 3 - Mus musculus (Mouse)| Length = 497 Score = 72.0 bits (175), Expect = 5e-12 Identities = 68/274 (24%), Positives = 127/274 (46%), Gaps = 15/274 (5%) Frame = +3 Query: 3 KGSNGTVVFEGSY--DGREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDD 173 +GS G+V F+ + G+ VA+K++ + S KEI + D P +V+ YG + Sbjct: 35 EGSYGSV-FKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCD-SPYVVKYYGSYFKN 92 Query: 174 NFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVH 353 ++I +E C S SD+ ++ + T+D ++ +++ + G+ + Sbjct: 93 TDLWIVMEYCGAG-----------SVSDIIRLRNKTLTED-----EIATILKSTLKGLEY 136 Query: 354 LHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPE 533 LH + IHRD+K N+L++ EG AKL+D G++ +L + M+ T G+ W APE Sbjct: 137 LHFMRKIHRDIKAGNILLNTEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPE 191 Query: 534 QLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP----- 698 ++ D++SLG + + +GK P+ + I+ +F++ P Sbjct: 192 VIQEIGYNCVADIWSLG-ITSIEMAEGKPPYAD--------IHPMRAIFMIPTNPPPTFR 242 Query: 699 -------EAVHLISLLLQPKPDERPTAMYAINHP 779 + + L P++R TA + HP Sbjct: 243 KPELWSDDFTDFVKKCLVKSPEQRATATQLLQHP 276
>Q9NRH2:SNRK_HUMAN SNF-related serine/threonine-protein kinase - Homo sapiens (Human)| Length = 765 Score = 72.0 bits (175), Expect = 5e-12 Identities = 71/255 (27%), Positives = 112/255 (43%), Gaps = 8/255 (3%) Frame = +3 Query: 39 YDGREVAVKRLLRSHTDIAQ-----KEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERC 203 + G +VAVK + ++ D +E++ + + PNIVRLY +Y+ LE Sbjct: 37 FTGEKVAVKVIDKTKLDTLATGHLFQEVR-CMKLVQHPNIVRLYEVIDTQTKLYLILELG 95 Query: 204 HCS-LADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHR 380 + D I +H ++GL K +V I + H L ++HR Sbjct: 96 DGGDMFDYIMKH-----------------EEGLNEDLAKKYFAQIVHAISYCHKLHVVHR 138 Query: 381 DLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPE-QLRRASQT 557 DLKP+NV+ ++ L KL+D G S + Q T GS + APE L Sbjct: 139 DLKPENVVFFEKQGL-VKLTDFGFSNKFQPGKKLT----TSCGSLAYSAPEILLGDEYDA 193 Query: 558 RAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHI-PEAVHLISLLLQP 734 A+D++SLG ++F + G+ PF E + + + V H+ E LI+ +LQ Sbjct: 194 PAVDIWSLGVILFMLVC-GQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQR 252 Query: 735 KPDERPTAMYAINHP 779 P R + NHP Sbjct: 253 DPKRRASLEEIENHP 267
>Q13882:PTK6_HUMAN Tyrosine-protein kinase 6 - Homo sapiens (Human)| Length = 451 Score = 72.0 bits (175), Expect = 5e-12 Identities = 70/250 (28%), Positives = 118/250 (47%), Gaps = 7/250 (2%) Frame = +3 Query: 24 VFEGSYDGR-EVAVKRLLRS---HTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYIS 191 VFEG + R +VA+K + R H + Q EIQ + R +I+ LY + VYI Sbjct: 205 VFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAM-KKLRHKHILALYAVVSVGDPVYII 263 Query: 192 LE-RCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLG 368 E SL +L++ SD EK+ LP +LL + V G+ +L S Sbjct: 264 TELMAKGSLLELLRD------SD-EKV---------LPVSELLDIAWQVAEGMCYLESQN 307 Query: 369 IIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRA 548 IHRDL +N+L+ + + K+ D G+++ ++ED+ H Y W APE L R Sbjct: 308 YIHRDLAARNILVGE--NTLCKVGDFGLARLIKEDVYLSHDHNIPY---KWTAPEALSRG 362 Query: 549 SQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINI-INGHFDLFVVDHIPEAVHLISLL 725 + D++S G L+ ++G+ P+ + + ++ + + P +VH + L Sbjct: 363 HYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLT 422 Query: 726 LQPK-PDERP 752 + P++RP Sbjct: 423 CWCRDPEQRP 432
>Q8G4G1:PKNA2_BIFLO Probable serine/threonine-protein kinase pknA2 - Bifidobacterium| longum Length = 757 Score = 72.0 bits (175), Expect = 5e-12 Identities = 63/253 (24%), Positives = 117/253 (46%), Gaps = 16/253 (6%) Frame = +3 Query: 45 GREVAVKRLLRSHTDIAQ-----------KEIQNLIASDRDPNIVRLYGCDQDDNFVYIS 191 GR VA+K + HT +A+ + N AS +P+IV++Y + + ++ Sbjct: 37 GRTVAIKVM---HTQLAKGPHREQFVERFRREANSAASIANPHIVQVYDTGEFNGLDFLV 93 Query: 192 LERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGI 371 +E H + +H E+ Q + L+++ + + G+ H G+ Sbjct: 94 MEYVH----GVNLRH-------------EMNAQGTFSVRETLRVVAETLDGLASAHRAGV 136 Query: 372 IHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRAS 551 +HRD+KP+N+LI+ G + +++D G++K + ++LS G G++ + APE + Sbjct: 137 VHRDIKPENILINDRGHV--QITDFGLAKAASQ--ATLSSTGMLLGTAAYLAPEMIENNQ 192 Query: 552 QTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHI-----PEAVHLI 716 T DL+S+G + + +T GK PF + + H D+ V + P I Sbjct: 193 ATAQGDLYSVGIMAWEMLT-GKVPFDSDNPVTLVFKHVHEDVPSVATVCQGIDPSVAAFI 251 Query: 717 SLLLQPKPDERPT 755 + L + D RPT Sbjct: 252 AHLTARQVDARPT 264
>O08874:PKN2_RAT Serine/threonine-protein kinase N2 - Rattus norvegicus (Rat)| Length = 985 Score = 72.0 bits (175), Expect = 5e-12 Identities = 68/228 (29%), Positives = 105/228 (46%), Gaps = 8/228 (3%) Frame = +3 Query: 90 IAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQ-HTDPSFSDVEK 266 + +K I + S R P +V L+ C Q V +E + + DL+ HTD FS+ Sbjct: 704 MCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVME--YAAGGDLMMHIHTDV-FSE--- 757 Query: 267 IDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDM 446 P+ + VV G+ +LH I++RDLK N+L+ E S+ K++D Sbjct: 758 -------------PRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEASV--KIADF 802 Query: 447 GISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF 626 G+ K E M T G+ + APE L S TRA+D + LG LI+ + G+ PF Sbjct: 803 GLCK---EGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLV-GESPF 858 Query: 627 GEYYERDINIINGHFDLFVVDHI-------PEAVHLISLLLQPKPDER 749 E ++ FD V D + EA+ ++ LL+ P+ R Sbjct: 859 PGDDEEEV------FDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERR 900
>Q8BWW9:PKN2_MOUSE Serine/threonine-protein kinase N2 - Mus musculus (Mouse)| Length = 983 Score = 72.0 bits (175), Expect = 5e-12 Identities = 68/228 (29%), Positives = 105/228 (46%), Gaps = 8/228 (3%) Frame = +3 Query: 90 IAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQ-HTDPSFSDVEK 266 + +K I + S R P +V L+ C Q V +E + + DL+ HTD FS+ Sbjct: 702 MCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVME--YAAGGDLMMHIHTDV-FSE--- 755 Query: 267 IDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDM 446 P+ + VV G+ +LH I++RDLK N+L+ EG + K++D Sbjct: 756 -------------PRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFV--KIADF 800 Query: 447 GISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF 626 G+ K E M T G+ + APE L S TRA+D + LG LI+ + G+ PF Sbjct: 801 GLCK---EGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLV-GESPF 856 Query: 627 GEYYERDINIINGHFDLFVVDHI-------PEAVHLISLLLQPKPDER 749 E ++ FD V D + EA+ ++ LL+ P+ R Sbjct: 857 PGDDEEEV------FDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERR 898
>Q16513:PKN2_HUMAN Serine/threonine-protein kinase N2 - Homo sapiens (Human)| Length = 984 Score = 72.0 bits (175), Expect = 5e-12 Identities = 68/228 (29%), Positives = 105/228 (46%), Gaps = 8/228 (3%) Frame = +3 Query: 90 IAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQ-HTDPSFSDVEK 266 + +K I + S R P +V L+ C Q V +E + + DL+ HTD FS+ Sbjct: 703 MCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVME--YAAGGDLMMHIHTDV-FSE--- 756 Query: 267 IDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDM 446 P+ + VV G+ +LH I++RDLK N+L+ EG + K++D Sbjct: 757 -------------PRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFV--KIADF 801 Query: 447 GISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF 626 G+ K E M T G+ + APE L S TRA+D + LG LI+ + G+ PF Sbjct: 802 GLCK---EGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLV-GESPF 857 Query: 627 GEYYERDINIINGHFDLFVVDHI-------PEAVHLISLLLQPKPDER 749 E ++ FD V D + EA+ ++ LL+ P+ R Sbjct: 858 PGDDEEEV------FDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERR 899
>Q10407:MKH1_SCHPO MAP kinase kinase kinase mkh1 - Schizosaccharomyces pombe (Fission| yeast) Length = 1116 Score = 72.0 bits (175), Expect = 5e-12 Identities = 57/175 (32%), Positives = 87/175 (49%), Gaps = 18/175 (10%) Frame = +3 Query: 309 QLLKLM-RDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISK---RLQEDM 476 QL++ + R V+ G+ +LHS GIIHRDLK N+LI +G K+SD GISK + ++ Sbjct: 930 QLVRFVSRQVLYGLSYLHSKGIIHRDLKADNLLIDFDG--VCKISDFGISKHSDNVYDND 987 Query: 477 SSLSHHGTGYGSSGWQAPEQLRRASQ--TRAMDLFSLGCLIFYCITKGKHPFGEYYERDI 650 ++LS G+ + W APE + Q + +D++SLGC++ + G+ P+ Sbjct: 988 ANLSMQGSIF----WMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLA-GRRPWS-----TD 1037 Query: 651 NIINGHFDL------------FVVDHIPEAVHLISLLLQPKPDERPTAMYAINHP 779 I F L V PEA+ ++ D RPTA +NHP Sbjct: 1038 EAIQAMFKLGTEKKAPPIPSELVSQVSPEAIQFLNACFTVNADVRPTAEELLNHP 1092
>O80397:M2K4_ARATH Mitogen-activated protein kinase kinase 4 - Arabidopsis thaliana| (Mouse-ear cress) Length = 366 Score = 72.0 bits (175), Expect = 5e-12 Identities = 69/260 (26%), Positives = 120/260 (46%), Gaps = 16/260 (6%) Frame = +3 Query: 48 REVAVKRLLRSHTDIAQKEIQNLIASDRD---PNIVRLYGCDQDDNFVYISLERCHCSLA 218 R A+K + +H + +++I I RD PN+V+ + + + + LE Sbjct: 103 RLYALKVIYGNHEETVRRQICREIEILRDVNHPNVVKCHEMFDQNGEIQVLLE------- 155 Query: 219 DLIQQHTDPSFSDVEKID-VELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQ 395 F D ++ +W + QL L R +++G+ +LHS I+HRD+KP Sbjct: 156 ----------FMDKGSLEGAHVWKEQ-----QLADLSRQILSGLAYLHSRHIVHRDIKPS 200 Query: 396 NVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRR-ASQTR---- 560 N+LI+ + + K++D G+S+ L + M + + G+ + +PE++ +Q + Sbjct: 201 NLLIN--SAKNVKIADFGVSRILAQTMDPCN---SSVGTIAYMSPERINTDLNQGKYDGY 255 Query: 561 AMDLFSLGCLI--FYCITKGKHPF-----GEYYERDINIINGHFDLFVVDHIPEAVHLIS 719 A D++SLG I FY G+ PF G++ I PE H IS Sbjct: 256 AGDIWSLGVSILEFYL---GRFPFPVSRQGDWASLMCAICMSQPPEAPATASPEFRHFIS 312 Query: 720 LLLQPKPDERPTAMYAINHP 779 LQ +P +R +AM + HP Sbjct: 313 CCLQREPGKRRSAMQLLQHP 332
>P10666:KS6AB_XENLA Ribosomal protein S6 kinase 2 beta - Xenopus laevis (African clawed| frog) Length = 629 Score = 72.0 bits (175), Expect = 5e-12 Identities = 57/195 (29%), Positives = 95/195 (48%), Gaps = 3/195 (1%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQ 230 +V K L+ + K ++++A P +VRL+ Q + +Y+ L+ DL Sbjct: 94 KVLKKATLKVRDRVRTKMERDILADVHHPFVVRLHYAFQTEGKLYLILDFLRGG--DLFT 151 Query: 231 QHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLIS 410 + + E DV+ + + ++ G+ HLHSLGII+RDLKP+N+L+ Sbjct: 152 RLSKEVMFTEE--DVKFY-------------LAELALGLDHLHSLGIIYRDLKPENILLD 196 Query: 411 KEGSLSAKLSDMGISKRLQEDMSSLSHHGTGY---GSSGWQAPEQLRRASQTRAMDLFSL 581 +EG + KL+D G+SK ++ H Y G+ + APE + R + D +S Sbjct: 197 EEGHI--KLTDFGLSK------EAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHGADWWSY 248 Query: 582 GCLIFYCITKGKHPF 626 G L+F +T G PF Sbjct: 249 GVLMFEMLT-GSLPF 262 Score = 62.8 bits (151), Expect = 3e-09 Identities = 61/195 (31%), Positives = 93/195 (47%), Gaps = 3/195 (1%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCS-LADLI 227 E AVK + +S D ++ EI+ L + PNI+ L ++ N +Y+ E L D I Sbjct: 441 EYAVKVIDKSKRDPSE-EIEILRRYGQHPNIITLKDVYEECNSIYLVTELMRGGELLDRI 499 Query: 228 QQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI 407 + FS+ E V L+T V + +LHS G++HRDLKP N+L Sbjct: 500 LRQK--FFSEREACSV-LFT---------------VCKTVEYLHSQGVVHRDLKPSNILY 541 Query: 408 SKEGS--LSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 E S ++ D G SK+L+ + L T ++ + APE L+R D++SL Sbjct: 542 VDESGDPESIRICDFGFSKQLRAENGLLM---TPCYTANFVAPEVLKRQGYDEGCDIWSL 598 Query: 582 GCLIFYCITKGKHPF 626 G L+ Y + G PF Sbjct: 599 GILL-YTMLAGYTPF 612
>Q8K1Y2:KPCD3_MOUSE Serine/threonine-protein kinase D3 - Mus musculus (Mouse)| Length = 889 Score = 72.0 bits (175), Expect = 5e-12 Identities = 74/286 (25%), Positives = 135/286 (47%), Gaps = 14/286 (4%) Frame = +3 Query: 21 VVFEGSY--DGREVAVKRLLRSHTDIAQK-EIQNLIASDRD---PNIVRLYGCDQDDNFV 182 +V+ G + GR+VA+K + + Q+ +++N +A ++ P IV L + V Sbjct: 588 IVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERV 647 Query: 183 YISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHS 362 ++ +E+ H + ++I + LP ++ ++ + +LH Sbjct: 648 FVVMEKLHGDMLEMILSSE----------------KSRLPERITKFMVTQILVALRNLHF 691 Query: 363 LGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQL 539 I+H DLKP+NVL+ S E KL D G ++ + E S + G+ + APE L Sbjct: 692 KNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEK----SFRRSVVGTPAYLAPEVL 747 Query: 540 RRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------E 701 R R++D++S+G +++ ++ G PF E + + I N F+ P E Sbjct: 748 RSKGYNRSLDMWSVGVIVYVSLS-GTFPFNEDEDINDQIQNA---AFMYPPNPWREISSE 803 Query: 702 AVHLISLLLQPKPDERPTAMYAINHPLFWSPELRL-LFLRDTSDRI 836 A+ LI+ LLQ K +R + +++HP W + + L LR+ RI Sbjct: 804 AIDLINNLLQVKMRKRYSVDKSLSHP--WLQDYQTWLDLREFETRI 847
>Q8BW96:KCC1D_MOUSE Calcium/calmodulin-dependent protein kinase type 1D - Mus musculus| (Mouse) Length = 385 Score = 72.0 bits (175), Expect = 5e-12 Identities = 75/264 (28%), Positives = 121/264 (45%), Gaps = 11/264 (4%) Frame = +3 Query: 21 VVFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRD---PNIVRLYGCDQDDNFVYIS 191 V+ E G+ AVK + + + I+N IA R NIV L + N +Y+ Sbjct: 38 VLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLV 97 Query: 192 LERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGI 371 ++ S +L + + F +T+ + L+R V+ + +LH +GI Sbjct: 98 MQLV--SGGELFDRIVEKGF----------YTEKDAST-----LIRQVLDAVYYLHRMGI 140 Query: 372 IHRDLKPQNVL-ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRA 548 +HRDLKP+N+L S++ +SD G+SK E + T G+ G+ APE L + Sbjct: 141 VHRDLKPENLLYYSQDEESKIMISDFGLSK--MEGKGDVM--STACGTPGYVAPEVLAQK 196 Query: 549 SQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIING------HFDLFVVDHIPE-AV 707 ++A+D +S+G +I Y + G PF Y E D + FD D I + A Sbjct: 197 PYSKAVDCWSIG-VIAYILLCGYPPF--YDENDSKLFEQILKAEYEFDSPYWDDISDSAK 253 Query: 708 HLISLLLQPKPDERPTAMYAINHP 779 I L++ P++R T A HP Sbjct: 254 DFIRNLMEKDPNKRYTCEQAARHP 277
>Q8IU85:KCC1D_HUMAN Calcium/calmodulin-dependent protein kinase type 1D - Homo sapiens| (Human) Length = 385 Score = 72.0 bits (175), Expect = 5e-12 Identities = 75/264 (28%), Positives = 121/264 (45%), Gaps = 11/264 (4%) Frame = +3 Query: 21 VVFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRD---PNIVRLYGCDQDDNFVYIS 191 V+ E G+ AVK + + + I+N IA R NIV L + N +Y+ Sbjct: 38 VLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLV 97 Query: 192 LERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGI 371 ++ S +L + + F +T+ + L+R V+ + +LH +GI Sbjct: 98 MQLV--SGGELFDRIVEKGF----------YTEKDAST-----LIRQVLDAVYYLHRMGI 140 Query: 372 IHRDLKPQNVL-ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRA 548 +HRDLKP+N+L S++ +SD G+SK E + T G+ G+ APE L + Sbjct: 141 VHRDLKPENLLYYSQDEESKIMISDFGLSK--MEGKGDVM--STACGTPGYVAPEVLAQK 196 Query: 549 SQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIING------HFDLFVVDHIPE-AV 707 ++A+D +S+G +I Y + G PF Y E D + FD D I + A Sbjct: 197 PYSKAVDCWSIG-VIAYILLCGYPPF--YDENDSKLFEQILKAEYEFDSPYWDDISDSAK 253 Query: 708 HLISLLLQPKPDERPTAMYAINHP 779 I L++ P++R T A HP Sbjct: 254 DFIRNLMEKDPNKRYTCEQAARHP 277
>Q5ZJB4:IKKA_CHICK Inhibitor of nuclear factor kappa-B kinase subunit alpha - Gallus| gallus (Chicken) Length = 759 Score = 72.0 bits (175), Expect = 5e-12 Identities = 53/170 (31%), Positives = 83/170 (48%), Gaps = 6/170 (3%) Frame = +3 Query: 135 PNIVRLYGCDQDDNFVY-----ISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGL 299 PN+VR ++ NF+ +++E C S D+ K+ + GL Sbjct: 85 PNVVRACEVPEEMNFLVNDVPLLAMEYC--------------SGGDLRKLLNKPENCCGL 130 Query: 300 PSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKE-GSLSAKLSDMGISKRLQEDM 476 Q+L L+ D+ +GI +LH IIHRDLKP+N+++ E G + K+ D+G +K L + Sbjct: 131 KESQILSLLSDIGSGIQYLHENRIIHRDLKPENIVLQDEGGKIIHKIIDLGYAKDLDQGS 190 Query: 477 SSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF 626 S GT + APE S + +D +S G ++F CI G PF Sbjct: 191 LCTSFVGT----LQYLAPELFENKSYSVTVDYWSFGTMVFECIA-GFRPF 235
>Q61772:EPHA7_MOUSE Ephrin type-A receptor 7 precursor - Mus musculus (Mouse)| Length = 998 Score = 72.0 bits (175), Expect = 5e-12 Identities = 59/238 (24%), Positives = 110/238 (46%), Gaps = 5/238 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PN+V L G V I +E D Sbjct: 662 VAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDA 721 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L +G +HRDL +N+L Sbjct: 722 FLRKHDGQFTVI----------------QLVGMLRGIAAGMRYLADMGYVHRDLAARNIL 765 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 ++ +L K+SD G+S+ +++D ++ G W APE ++ T A D++S G Sbjct: 766 VNS--NLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYG 823 Query: 585 CLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQPKPDERP 752 +++ ++ G+ P+ + +D I I + L P +H + L Q ERP Sbjct: 824 IVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKDRAERP 881
>O08680:EPHA3_RAT Ephrin type-A receptor 3 precursor - Rattus norvegicus (Rat)| Length = 984 Score = 72.0 bits (175), Expect = 5e-12 Identities = 59/242 (24%), Positives = 107/242 (44%), Gaps = 3/242 (1%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PNI+RL G V I E D Sbjct: 651 VAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDS 710 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + +G+ +L +G +HRDL +N+L Sbjct: 711 FLRKHDAQFTVI----------------QLVGMLRGIASGMKYLSDMGYVHRDLAARNIL 754 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 I+ +L K+SD G+S+ L++D + G W +PE T A D++S G Sbjct: 755 IN--SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPVRWTSPEATAYRKFTSASDVWSYG 812 Query: 585 CLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMY 764 +++ ++ G+ P+ E +D V+ + E L P P + P A+Y Sbjct: 813 IVLWEVMSYGERPYWEMSNQD-----------VIKAVDEGYRL------PLPMDCPAALY 855 Query: 765 AI 770 + Sbjct: 856 QL 857
>O13148:EPA4A_DANRE Ephrin type-A receptor 4a - Danio rerio (Zebrafish) (Brachydanio| rerio) Length = 292 Score = 72.0 bits (175), Expect = 5e-12 Identities = 66/254 (25%), Positives = 116/254 (45%), Gaps = 14/254 (5%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +TD +++ +++ PNI+RL G V I E D Sbjct: 24 VAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIRLEGVVTKCKPVMIITEYMENGSLDA 83 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + +G+ +L + +HRDL +N+L Sbjct: 84 FLRKNDGRFTVI----------------QLVGILRGIASGMKYLSDMSYVHRDLAARNIL 127 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSS--LSHHGTG-YGSSG------WQAPEQLRRASQT 557 ++ +L K+SD G+S+ L+ED + + TG Y S G W APE + T Sbjct: 128 VN--SNLVCKVSDFGMSRVLEEDPDAAYTTREITGTYQSQGGKIPIRWTAPEAITYRKFT 185 Query: 558 RAMDLFSLGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL-LLQ 731 A D++S G +++ ++ G+ P+ + +D I I + L P ++H + L Q Sbjct: 186 SASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPVSLHQLMLDCWQ 245 Query: 732 PKPDERPTAMYAIN 773 + ERP +N Sbjct: 246 KERAERPKFSQIVN 259
>A4K2M3:STK4_PAPAN Serine/threonine-protein kinase 4 - Papio anubis (Olive baboon)| Length = 487 Score = 71.6 bits (174), Expect = 7e-12 Identities = 63/258 (24%), Positives = 117/258 (45%), Gaps = 13/258 (5%) Frame = +3 Query: 45 GREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLAD 221 G+ VA+K++ + S KEI + D P++V+ YG + ++I +E C Sbjct: 53 GQIVAIKQVPVESDLQEIIKEISIMQQCD-SPHVVKYYGSYFKNTDLWIVMEYCGAG--- 108 Query: 222 LIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 S SD+ ++ + T+D ++ +++ + G+ +LH + IHRD+K N+ Sbjct: 109 --------SVSDIIRLRNKTLTED-----EIATILQSTLKGLEYLHFMRKIHRDIKAGNI 155 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L++ EG AKL+D G++ +L + M+ T G+ W APE ++ D++SL Sbjct: 156 LLNTEG--QAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEVIQEIGYNCVADIWSL 210 Query: 582 GCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------------EAVHLISLL 725 G + +GK P+ + I+ +F++ P + Sbjct: 211 GITAIE-MAEGKPPYAD--------IHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQC 261 Query: 726 LQPKPDERPTAMYAINHP 779 L P++R TA + HP Sbjct: 262 LVKSPEQRATATQLLQHP 279
>Q9JI11:STK4_MOUSE Serine/threonine-protein kinase 4 - Mus musculus (Mouse)| Length = 487 Score = 71.6 bits (174), Expect = 7e-12 Identities = 63/258 (24%), Positives = 118/258 (45%), Gaps = 13/258 (5%) Frame = +3 Query: 45 GREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLAD 221 G+ VA+K++ + S KEI + D P++V+ YG + ++I +E C Sbjct: 53 GQIVAIKQVPVESDLQEIIKEISIMQQCD-SPHVVKYYGSYFKNTDLWIVMEYCGAG--- 108 Query: 222 LIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 S SD+ ++ + T+D ++ +++ + G+ +LH + IHRD+K N+ Sbjct: 109 --------SVSDIIRLRNKTLTED-----EIATILQSTLKGLEYLHFMRKIHRDIKAGNI 155 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L++ EG AKL+D G++ +L + M+ T G+ W APE ++ D++SL Sbjct: 156 LLNTEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEVIQEIGYNCVADIWSL 210 Query: 582 GCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------------EAVHLISLL 725 G + +GK P+ + I+ +F++ P + + Sbjct: 211 GITAIE-MAEGKPPYAD--------IHPMRAIFMIPTNPPPTFRKPELWSDNFMDFVKQC 261 Query: 726 LQPKPDERPTAMYAINHP 779 L P++R TA + HP Sbjct: 262 LVKSPEQRATATQLLQHP 279
>Q5E9L6:STK4_BOVIN Serine/threonine-protein kinase 4 - Bos taurus (Bovine)| Length = 487 Score = 71.6 bits (174), Expect = 7e-12 Identities = 63/258 (24%), Positives = 118/258 (45%), Gaps = 13/258 (5%) Frame = +3 Query: 45 GREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLAD 221 G+ VA+K++ + S KEI + D P++V+ YG + ++I +E C Sbjct: 53 GQIVAIKQVPVESDLQEIIKEISIMQQCD-SPHVVKYYGSYFKNTDLWIVMEYCGAG--- 108 Query: 222 LIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 S SD+ ++ + T+D ++ +++ + G+ +LH + IHRD+K N+ Sbjct: 109 --------SVSDIIRLRNKTLTED-----EIATILQSTLKGLEYLHFMRKIHRDIKAGNI 155 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L++ EG AKL+D G++ +L + M+ T G+ W APE ++ D++SL Sbjct: 156 LLNTEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEVIQEIGYNCVADIWSL 210 Query: 582 GCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------------EAVHLISLL 725 G + +GK P+ + I+ +F++ P + + Sbjct: 211 GITAIE-MAEGKPPYAD--------IHPMRAIFMIPTNPPPTFRKPELWSDSFMDFVKQC 261 Query: 726 LQPKPDERPTAMYAINHP 779 L P++R TA + HP Sbjct: 262 LVKSPEQRATATQLLQHP 279
>Q7Z8E9:STE20_MAGGR Serine/threonine-protein kinase MST20 - Magnaporthe grisea (Rice| blast fungus) (Pyricularia grisea) Length = 914 Score = 71.6 bits (174), Expect = 7e-12 Identities = 56/199 (28%), Positives = 93/199 (46%), Gaps = 1/199 (0%) Frame = +3 Query: 33 GSYDGREVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFV-YISLERCHC 209 G Y G E RL+ I Q ++ D N + + N V +I C Sbjct: 647 GVYTGHERGSNRLVA----IKQMNLEQQPKKDLIINEILVMKDSSHPNIVNFIDSYLCGG 702 Query: 210 SLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLK 389 L +++ S +DV ++ + Q+ + R+ + G+ HLHS G+IHRD+K Sbjct: 703 ELWVVMEFMEGGSLTDVVTFNI-------MTEGQIASVCRETLLGLQHLHSKGVIHRDIK 755 Query: 390 PQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMD 569 N+L+S EG++ KL+D G + E + + T G+ W APE + R R +D Sbjct: 756 SDNILLSMEGNI--KLTDFGFCATINEAQNKRT---TMVGTPYWMAPEVVTRKEYGRKVD 810 Query: 570 LFSLGCLIFYCITKGKHPF 626 ++SLG + I +G+ P+ Sbjct: 811 IWSLGIMAIEMI-EGEPPY 828
>Q2ULU3:STE20_ASPOR Serine/threonine-protein kinase ste20 - Aspergillus oryzae| Length = 848 Score = 71.6 bits (174), Expect = 7e-12 Identities = 49/161 (30%), Positives = 85/161 (52%), Gaps = 4/161 (2%) Frame = +3 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLS 488 Q+ + R+ + G+ HLHS G+IHRD+K N+L+S +G++ KL+D G ++ + S + Sbjct: 662 QIAAVCRETLNGLQHLHSKGVIHRDIKSDNILLSLDGNI--KLTDFGFCAQIND---SHN 716 Query: 489 HHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-GEYYERDINIING 665 T G+ W APE + R R +D++SLG + I +G+ P+ E R + +I Sbjct: 717 KRNTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMI-EGEPPYLTESPLRALYLIAT 775 Query: 666 HFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 + + D P + L L+ P++R +A + HP Sbjct: 776 NGTPTIKDEQSLTPVFRDFLHLALKVDPEKRASAHDLLKHP 816
>O15530:PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 - Homo sapiens| (Human) Length = 556 Score = 71.6 bits (174), Expect = 7e-12 Identities = 70/252 (27%), Positives = 118/252 (46%), Gaps = 10/252 (3%) Frame = +3 Query: 3 KGSNGTVVFEGSY-DGREVAVKRLLRSHTDIAQKEIQNLIASDRD-------PNIVRLYG 158 +GS TVV RE A+K L + H I ++ + +RD P V+LY Sbjct: 90 EGSFSTVVLARELATSREYAIKILEKRH--IIKENKVPYVTRERDVMSRLDHPFFVKLYF 147 Query: 159 CDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVV 338 QDD +Y L + +L++ ++ +T + +V Sbjct: 148 TFQDDEKLYFGLS--YAKNGELLKYIR--KIGSFDETCTRFYTAE-------------IV 190 Query: 339 AGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSG 518 + + +LH GIIHRDLKP+N+L++++ + +++D G +K L + S + + G++ Sbjct: 191 SALEYLHGKGIIHRDLKPENILLNED--MHIQITDFGTAKVLSPE-SKQARANSFVGTAQ 247 Query: 519 WQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF--GEYYERDINIINGHFDLFVVDH 692 + +PE L S ++ DL++LGC+I Y + G PF G Y II +D F Sbjct: 248 YVSPELLTEKSACKSSDLWALGCII-YQLVAGLPPFRAGNEYLIFQKIIKLEYD-FPEKF 305 Query: 693 IPEAVHLISLLL 728 P+A L+ LL Sbjct: 306 FPKARDLVEKLL 317
>P29317:EPHA2_HUMAN Ephrin type-A receptor 2 precursor - Homo sapiens (Human)| Length = 976 Score = 71.6 bits (174), Expect = 7e-12 Identities = 60/236 (25%), Positives = 106/236 (44%), Gaps = 4/236 (1%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ + + ++ NI+RL G + I E D Sbjct: 643 VAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDK 702 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D FS + QL+ ++R + AG+ +L ++ +HRDL +N+L Sbjct: 703 FLREKDGEFSVL----------------QLVGMLRGIAAGMKYLANMNYVHRDLAARNIL 746 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 ++ +L K+SD G+S+ L++D + G W APE + T A D++S G Sbjct: 747 VNS--NLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFG 804 Query: 585 CLIFYCITKGKHPFGEYYERDI-NIINGHFDLFVVDHIPEAVHLISLLLQPKPDER 749 +++ +T G+ P+ E ++ IN F L P A++ L++Q ER Sbjct: 805 IVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIY--QLMMQCWQQER 858
>Q9Z2B5:E2AK3_MOUSE Eukaryotic translation initiation factor 2-alpha kinase 3 precursor -| Mus musculus (Mouse) Length = 1114 Score = 71.6 bits (174), Expect = 7e-12 Identities = 45/169 (26%), Positives = 80/169 (47%), Gaps = 12/169 (7%) Frame = +3 Query: 315 LKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQED------- 473 L + + + LHS G++HRDLKP N+ + + + K+ D G+ + +D Sbjct: 913 LHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVV--KVGDFGLVTAMDQDEEEQTVL 970 Query: 474 --MSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERD 647 M + + H G+ + +PEQ+ + + +D+FSLG ++F + +PF ER Sbjct: 971 TPMPAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELL----YPFSTQMERV 1026 Query: 648 ---INIINGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMYAINHPLF 785 ++ N F L P+ ++ +L P P ERP A I + +F Sbjct: 1027 RILTDVRNLKFPLLFTQKYPQEHMMVQDMLSPSPTERPEATDIIENAIF 1075
>O14965:STK6_HUMAN Serine/threonine-protein kinase 6 - Homo sapiens (Human)| Length = 403 Score = 71.2 bits (173), Expect = 9e-12 Identities = 64/222 (28%), Positives = 98/222 (44%), Gaps = 5/222 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 R PNI+RLYG D VY+ LE ++ + + EL Sbjct: 189 RHPNILRLYGYFHDATRVYLILE-----------------YAPLGTVYRELQKLSKFDEQ 231 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLS 488 + + ++ + + HS +IHRD+KP+N+L+ G L K++D G S + S Sbjct: 232 RTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL--KIADFGWSVH-----APSS 284 Query: 489 HHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-----GEYYERDIN 653 T G+ + PE + +DL+SLG L + + GK PF E Y+R I+ Sbjct: 285 RRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPPFEANTYQETYKR-IS 342 Query: 654 IINGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMYAINHP 779 + F FV + A LIS LL+ P +RP + HP Sbjct: 343 RVEFTFPDFVTE---GARDLISRLLKHNPSQRPMLREVLEHP 381
>A4K2T0:STK4_MACMU Serine/threonine-protein kinase 4 - Macaca mulatta (Rhesus macaque)| Length = 487 Score = 71.2 bits (173), Expect = 9e-12 Identities = 63/258 (24%), Positives = 117/258 (45%), Gaps = 13/258 (5%) Frame = +3 Query: 45 GREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLAD 221 G+ VA+K++ + S KEI + D P++V+ YG + ++I +E C Sbjct: 53 GQIVAIKQVPVESDLQEIIKEISIMQQCD-SPHVVKYYGSYFKNTDLWIVMEYCGAG--- 108 Query: 222 LIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 S SD+ ++ + T+D ++ +++ + G+ +LH + IHRD+K N+ Sbjct: 109 --------SVSDIIRLRNKTLTED-----EIATILQSTLKGLEYLHFMRKIHRDIKAGNI 155 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L++ EG AKL+D G++ +L + M+ T G+ W APE ++ D++SL Sbjct: 156 LLNTEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEVIQEIGYNCVADIWSL 210 Query: 582 GCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------------EAVHLISLL 725 G + +GK P+ + I+ +F++ P + Sbjct: 211 GITAIE-MAEGKPPYAD--------IHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQC 261 Query: 726 LQPKPDERPTAMYAINHP 779 L P++R TA + HP Sbjct: 262 LVKSPEQRATATQLLQHP 279
>Q13043:STK4_HUMAN Serine/threonine-protein kinase 4 - Homo sapiens (Human)| Length = 487 Score = 71.2 bits (173), Expect = 9e-12 Identities = 63/258 (24%), Positives = 117/258 (45%), Gaps = 13/258 (5%) Frame = +3 Query: 45 GREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLAD 221 G+ VA+K++ + S KEI + D P++V+ YG + ++I +E C Sbjct: 53 GQIVAIKQVPVESDLQEIIKEISIMQQCD-SPHVVKYYGSYFKNTDLWIVMEYCGAG--- 108 Query: 222 LIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 S SD+ ++ + T+D ++ +++ + G+ +LH + IHRD+K N+ Sbjct: 109 --------SVSDIIRLRNKTLTED-----EIATILQSTLKGLEYLHFMRKIHRDIKAGNI 155 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L++ EG AKL+D G++ +L + M+ T G+ W APE ++ D++SL Sbjct: 156 LLNTEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEVIQEIGYNCVADIWSL 210 Query: 582 GCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------------EAVHLISLL 725 G + +GK P+ + I+ +F++ P + Sbjct: 211 GITAIE-MAEGKPPYAD--------IHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQC 261 Query: 726 LQPKPDERPTAMYAINHP 779 L P++R TA + HP Sbjct: 262 LVKSPEQRATATQLLQHP 279
>A4K2Y1:STK4_CERAE Serine/threonine-protein kinase 4 - Cercopithecus aethiops (Green| monkey) (Grivet) Length = 487 Score = 71.2 bits (173), Expect = 9e-12 Identities = 63/258 (24%), Positives = 117/258 (45%), Gaps = 13/258 (5%) Frame = +3 Query: 45 GREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLAD 221 G+ VA+K++ + S KEI + D P++V+ YG + ++I +E C Sbjct: 53 GQIVAIKQVPVESDLQEIIKEISIMQQCD-SPHVVKYYGSYFKNTDLWIVMEYCGAG--- 108 Query: 222 LIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 S SD+ ++ + T+D ++ +++ + G+ +LH + IHRD+K N+ Sbjct: 109 --------SVSDIIRLRNKTLTED-----EIATILQSTLKGLEYLHFMRKIHRDIKAGNI 155 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L++ EG AKL+D G++ +L + M+ T G+ W APE ++ D++SL Sbjct: 156 LLNTEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEVIQEIGYNCVADIWSL 210 Query: 582 GCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------------EAVHLISLL 725 G + +GK P+ + I+ +F++ P + Sbjct: 211 GITAIE-MAEGKPPYAD--------IHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQC 261 Query: 726 LQPKPDERPTAMYAINHP 779 L P++R TA + HP Sbjct: 262 LVKSPEQRATATQLLQHP 279
>Q63651:RK_RAT Rhodopsin kinase precursor - Rattus norvegicus (Rat)| Length = 564 Score = 71.2 bits (173), Expect = 9e-12 Identities = 36/111 (32%), Positives = 65/111 (58%) Frame = +3 Query: 294 GLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQED 473 G P P+ + +++G+ HLH I++RDLKP+NVL+ +G++ ++SD+G++ L+E Sbjct: 288 GFPEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNI--RISDLGLAVELKEG 345 Query: 474 MSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF 626 + + G+ G+ APE LR ++D F+LG ++ I + PF Sbjct: 346 QNKTKGYA---GTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIA-ARGPF 392
>Q9H4B4:PLK3_HUMAN Serine/threonine-protein kinase PLK3 - Homo sapiens (Human)| Length = 646 Score = 71.2 bits (173), Expect = 9e-12 Identities = 68/256 (26%), Positives = 115/256 (44%), Gaps = 6/256 (2%) Frame = +3 Query: 36 SYDGREVAVKRLLRSHTDIAQKEIQNLIASDRD---PNIVRLYGCDQDDNFVYISLERCH 206 +Y + + R+ + H +++I N I RD +IVR +D + +YI LE C Sbjct: 87 AYAVKVIPQSRVAKPHQ---REKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCS 143 Query: 207 CSLADLIQQHTDPSFSDVEKIDVELW-TQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRD 383 K +W + L P++ +R +++G+ +LH GI+HRD Sbjct: 144 ------------------RKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 185 Query: 384 LKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRA 563 LK N I++ ++ K+ D G++ RL+ T G+ + APE L R Sbjct: 186 LKLGNFFITE--NMELKVGDFGLAARLEPPE---QRKKTICGTPNYVAPEVLLRQGHGPE 240 Query: 564 MDLFSLGCLIFYCITKGKHPF--GEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPK 737 D++SLGC + Y + G PF + E I H+ L +P A L++ +L+ Sbjct: 241 ADVWSLGC-VMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLP-ARQLLAAILRAS 298 Query: 738 PDERPTAMYAINHPLF 785 P +RP+ + H F Sbjct: 299 PRDRPSIDQILRHDFF 314
>Q15418:KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 - Homo sapiens (Human)| Length = 735 Score = 71.2 bits (173), Expect = 9e-12 Identities = 56/195 (28%), Positives = 96/195 (49%), Gaps = 3/195 (1%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQ 230 +V K L+ + K ++++A P +V+L+ Q + +Y+ L+ DL Sbjct: 94 KVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGG--DLFT 151 Query: 231 QHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLIS 410 + + E DV+ + + ++ G+ HLHSLGII+RDLKP+N+L+ Sbjct: 152 RLSKEVMFTEE--DVKFY-------------LAELALGLDHLHSLGIIYRDLKPENILLD 196 Query: 411 KEGSLSAKLSDMGISKRLQEDMSSLSHHGTGY---GSSGWQAPEQLRRASQTRAMDLFSL 581 +EG + KL+D G+SK ++ H Y G+ + APE + R + + D +S Sbjct: 197 EEGHI--KLTDFGLSK------EAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSY 248 Query: 582 GCLIFYCITKGKHPF 626 G L+F +T G PF Sbjct: 249 GVLMFEMLT-GSLPF 262 Score = 64.7 bits (156), Expect = 8e-10 Identities = 69/253 (27%), Positives = 111/253 (43%), Gaps = 10/253 (3%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQ 230 E AVK + +S D ++ EI+ L+ + PNI+ L D VY+ E +L+ Sbjct: 443 EYAVKVIDKSKRDPSE-EIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGG--ELLD 499 Query: 231 QHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL-I 407 + F + L T + + +LHS G++HRDLKP N+L + Sbjct: 500 KILRQKFFSEREASFVLHT---------------IGKTVEYLHSQGVVHRDLKPSNILYV 544 Query: 408 SKEGSLSA-KLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 + G+ ++ D G +K+L+ + L T ++ + APE L+R D++SLG Sbjct: 545 DESGNPECLRICDFGFAKQLRAENGLLM---TPCYTANFVAPEVLKRQGYDEGCDIWSLG 601 Query: 585 CLIFYCITKGKHPFGE-----YYERDINIINGHFDLFVVDH---IPEAVHLISLLLQPKP 740 L+ Y + G PF E I +G F L + A L+S +L P Sbjct: 602 ILL-YTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 660 Query: 741 DERPTAMYAINHP 779 +R TA + HP Sbjct: 661 HQRLTAKQVLQHP 673
>Q39030:KPK19_ARATH Serine/threonine-protein kinase AtPK19 - Arabidopsis thaliana| (Mouse-ear cress) Length = 471 Score = 71.2 bits (173), Expect = 9e-12 Identities = 50/143 (34%), Positives = 81/143 (56%), Gaps = 3/143 (2%) Frame = +3 Query: 330 DVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYG 509 ++V+ + HLH GI+HRDLKP+N+L+ +G + L+D G++K +E+ S S GT Sbjct: 246 EIVSAVSHLHEKGIMHRDLKPENILMDVDGHV--MLTDFGLAKEFEENTRSNSMCGT--- 300 Query: 510 SSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-GEYYERDINIINGHFDL--F 680 + + APE +R +A D +S+G L++ +T GK PF G + I+ L F Sbjct: 301 -TEYMAPEIVRGKGHDKAADWWSVGILLYEMLT-GKPPFLGSKGKIQQKIVKDKIKLPQF 358 Query: 681 VVDHIPEAVHLISLLLQPKPDER 749 + + EA L+ LLQ +P+ R Sbjct: 359 LSN---EAHALLKGLLQKEPERR 378
>Q5ZKI0:KCC2D_CHICK Calcium/calmodulin-dependent protein kinase type II delta chain -| Gallus gallus (Chicken) Length = 479 Score = 71.2 bits (173), Expect = 9e-12 Identities = 60/223 (26%), Positives = 106/223 (47%), Gaps = 6/223 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PNIVRL+ ++ F Y+ + DL+ F D+ ++ Sbjct: 69 KHPNIVRLHDSISEEGFHYL--------VFDLVTG--GELFEDIV-------AREYYSEA 111 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSL 485 ++ ++ + H H GI+HRDLKP+N+L+ SK + KL+D G++ +Q + + Sbjct: 112 DASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGEQQAW 171 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NII 659 G+ G+ +PE LR+ + +D+++ G +I Y + G PF + + + I Sbjct: 172 FGFA---GTPGYLSPEVLRKDPYGKPVDMWACG-VILYILLVGYPPFWDEDQHRLYQQIK 227 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G +D + PEA LI+ +L P +R TA A+ HP Sbjct: 228 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
>Q1KL86:EPHA2_MACFA Ephrin type-A receptor 2 precursor - Macaca fascicularis (Crab eating| macaque) (Cynomolgus monkey) Length = 976 Score = 71.2 bits (173), Expect = 9e-12 Identities = 60/236 (25%), Positives = 106/236 (44%), Gaps = 4/236 (1%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ + + ++ NI+RL G + I E D Sbjct: 643 VAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEFMENGALDK 702 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D FS + QL+ ++R + AG+ +L ++ +HRDL +N+L Sbjct: 703 FLREKDGEFSVL----------------QLVGMLRGIAAGMKYLANMNYVHRDLAARNIL 746 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 ++ +L K+SD G+S+ L++D + G W APE + T A D++S G Sbjct: 747 VNS--NLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFG 804 Query: 585 CLIFYCITKGKHPFGEYYERDI-NIINGHFDLFVVDHIPEAVHLISLLLQPKPDER 749 +++ +T G+ P+ E ++ IN F L P A++ L++Q ER Sbjct: 805 IVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIY--QLMMQCWQQER 858
>O96017:CHK2_HUMAN Serine/threonine-protein kinase Chk2 - Homo sapiens (Human)| Length = 543 Score = 71.2 bits (173), Expect = 9e-12 Identities = 61/187 (32%), Positives = 94/187 (50%), Gaps = 10/187 (5%) Frame = +3 Query: 333 VVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYG 509 ++ + +LH GIIHRDLKP+NVL+ S+E K++D G SK L E +SL T G Sbjct: 331 MLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGE--TSLMR--TLCG 386 Query: 510 SSGWQAPEQL---RRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYER---DINIINGHF 671 + + APE L A RA+D +SLG ++F C++ G PF E+ + I +G + Sbjct: 387 TPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEHRTQVSLKDQITSGKY 445 Query: 672 DLFV---VDHIPEAVHLISLLLQPKPDERPTAMYAINHPLFWSPELRLLFLRDTSDRIEK 842 + + +A+ L+ LL P R T A+ HP +++ F S+ E Sbjct: 446 NFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENES 505 Query: 843 TTETDLL 863 T +L Sbjct: 506 TALPQVL 512
>Q63699:CDK2_RAT Cell division protein kinase 2 - Rattus norvegicus (Rat)| Length = 298 Score = 71.2 bits (173), Expect = 9e-12 Identities = 58/195 (29%), Positives = 98/195 (50%), Gaps = 6/195 (3%) Frame = +3 Query: 45 GREVAVKRL-LRSHTD----IAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHC 209 G VA+K++ L + T+ A +EI +L+ PNIV+L +N +Y+ E H Sbjct: 27 GEVVALKKIRLDTETEGVPSTAIREI-SLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ 85 Query: 210 SLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLK 389 L F D + GLP P + + ++ G+ HS ++HRDLK Sbjct: 86 DLK---------KFMDASALT-------GLPLPLIKSYLFQLLQGLAFCHSHRVLHRDLK 129 Query: 390 PQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRAS-QTRAM 566 PQN+LI+ EGS+ KL+D G+++ + + +H + ++APE L + A+ Sbjct: 130 PQNLLINAEGSI--KLADFGLARAFGVPVRTYTHEVV---TLWYRAPEILLGCKYYSTAV 184 Query: 567 DLFSLGCLIFYCITK 611 D++SLGC+ +T+ Sbjct: 185 DIWSLGCIFAEMVTR 199
>P48963:CDK2_MESAU Cell division protein kinase 2 - Mesocricetus auratus (Golden| hamster) Length = 298 Score = 71.2 bits (173), Expect = 9e-12 Identities = 57/195 (29%), Positives = 98/195 (50%), Gaps = 6/195 (3%) Frame = +3 Query: 45 GREVAVKRL-LRSHTD----IAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHC 209 G VA+K++ L + T+ A +EI +L+ PNIV+L +N +Y+ E H Sbjct: 27 GEVVALKKIRLDTETEGVPSTAIREI-SLLKELNHPNIVKLLDVIHTENKLYLVFELLHQ 85 Query: 210 SLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLK 389 L F D + G+P P + + ++ G+ HS ++HRDLK Sbjct: 86 DLK---------KFMDASAVT-------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLK 129 Query: 390 PQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRAS-QTRAM 566 PQN+LI+ EGS+ KL+D G+++ + + +H + ++APE L + A+ Sbjct: 130 PQNLLINAEGSI--KLADFGLARAFGVPVRTYTHEVV---TLWYRAPEILLGCKYYSTAV 184 Query: 567 DLFSLGCLIFYCITK 611 D++SLGC+ +T+ Sbjct: 185 DIWSLGCIFAEMVTR 199
>P09324:YES_CHICK Tyrosine-protein kinase Yes - Gallus gallus (Chicken)| Length = 541 Score = 70.9 bits (172), Expect = 1e-11 Identities = 47/158 (29%), Positives = 79/158 (50%), Gaps = 2/158 (1%) Frame = +3 Query: 297 LPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDM 476 L PQL+ + + G+ ++ + IHRDL+ N+L+ +L K++D G++ RL ED Sbjct: 366 LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG--DNLVCKIADFGLA-RLIEDN 422 Query: 477 SSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI-N 653 + G + W APE T D++S G L+ +TKG+ P+ R++ Sbjct: 423 EYTARQGAKFPIK-WTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLE 481 Query: 654 IINGHFDLFVVDHIPEAVH-LISLLLQPKPDERPTAMY 764 + + + PE++H L+ L + PDERPT Y Sbjct: 482 QVERGYRMPCPQGCPESLHELMKLCWKKDPDERPTFEY 519
>P00527:YES_AVISY Tyrosine-protein kinase transforming protein YES - Avian sarcoma| virus (strain Y73) Length = 528 Score = 70.9 bits (172), Expect = 1e-11 Identities = 47/158 (29%), Positives = 79/158 (50%), Gaps = 2/158 (1%) Frame = +3 Query: 297 LPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDM 476 L PQL+ + + G+ ++ + IHRDL+ N+L+ +L K++D G++ RL ED Sbjct: 358 LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG--DNLVCKIADFGLA-RLIEDN 414 Query: 477 SSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI-N 653 + G + W APE T D++S G L+ +TKG+ P+ R++ Sbjct: 415 EYTARQGAKFPIK-WTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLE 473 Query: 654 IINGHFDLFVVDHIPEAVH-LISLLLQPKPDERPTAMY 764 + + + PE++H L+ L + PDERPT Y Sbjct: 474 QVERGYRMPCPQGCPESLHELMKLCWKKDPDERPTFEY 511
>Q02858:TIE2_MOUSE Angiopoietin-1 receptor precursor - Mus musculus (Mouse)| Length = 1122 Score = 70.9 bits (172), Expect = 1e-11 Identities = 67/250 (26%), Positives = 114/250 (45%), Gaps = 15/250 (6%) Frame = +3 Query: 51 EVAVKRLLR-----SHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERC-HCS 212 + A+KR+ H D A E++ L PNI+ L G + ++Y+++E H + Sbjct: 849 DAAIKRMKEYASKDDHRDFAG-ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGN 907 Query: 213 LADLIQQ----HTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHR 380 L D +++ TDP+F+ T L S QLL DV G+ +L IHR Sbjct: 908 LLDFLRKSRVLETDPAFAIANS------TASTLSSQQLLHFAADVARGMDYLSQKQFIHR 961 Query: 381 DLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTR 560 DL +N+L+ + + AK++D G+S+ + + G W A E L + T Sbjct: 962 DLAARNILVGE--NYIAKIADFGLSRGQEVYVKKT----MGRLPVRWMAIESLNYSVYTT 1015 Query: 561 AMDLFSLGCLIFYCITKGKHPF-----GEYYERDINIINGHFDLFVVDHIPEAVHLISLL 725 D++S G L++ ++ G P+ E YE+ + G+ ++ E L+ Sbjct: 1016 NSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEK---LPQGYRLEKPLNCDDEVYDLMRQC 1072 Query: 726 LQPKPDERPT 755 + KP ERP+ Sbjct: 1073 WREKPYERPS 1082
>Q02763:TIE2_HUMAN Angiopoietin-1 receptor precursor - Homo sapiens (Human)| Length = 1124 Score = 70.9 bits (172), Expect = 1e-11 Identities = 67/250 (26%), Positives = 114/250 (45%), Gaps = 15/250 (6%) Frame = +3 Query: 51 EVAVKRLLR-----SHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERC-HCS 212 + A+KR+ H D A E++ L PNI+ L G + ++Y+++E H + Sbjct: 851 DAAIKRMKEYASKDDHRDFAG-ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGN 909 Query: 213 LADLIQQ----HTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHR 380 L D +++ TDP+F+ T L S QLL DV G+ +L IHR Sbjct: 910 LLDFLRKSRVLETDPAFAIANS------TASTLSSQQLLHFAADVARGMDYLSQKQFIHR 963 Query: 381 DLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTR 560 DL +N+L+ + + AK++D G+S+ + + G W A E L + T Sbjct: 964 DLAARNILVGE--NYVAKIADFGLSRGQEVYVKKT----MGRLPVRWMAIESLNYSVYTT 1017 Query: 561 AMDLFSLGCLIFYCITKGKHPF-----GEYYERDINIINGHFDLFVVDHIPEAVHLISLL 725 D++S G L++ ++ G P+ E YE+ + G+ ++ E L+ Sbjct: 1018 NSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEK---LPQGYRLEKPLNCDDEVYDLMRQC 1074 Query: 726 LQPKPDERPT 755 + KP ERP+ Sbjct: 1075 WREKPYERPS 1084
>Q06807:TIE2_BOVIN Angiopoietin-1 receptor precursor - Bos taurus (Bovine)| Length = 1125 Score = 70.9 bits (172), Expect = 1e-11 Identities = 67/250 (26%), Positives = 114/250 (45%), Gaps = 15/250 (6%) Frame = +3 Query: 51 EVAVKRLLR-----SHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERC-HCS 212 + A+KR+ H D A E++ L PNI+ L G + ++Y+++E H + Sbjct: 852 DAAIKRMKEYASKDDHRDFAG-ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGN 910 Query: 213 LADLIQQ----HTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHR 380 L D +++ TDP+F+ T L S QLL DV G+ +L IHR Sbjct: 911 LLDFLRKSRVLETDPAFAIANS------TASTLSSQQLLHFAADVARGMDYLSQKQFIHR 964 Query: 381 DLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTR 560 DL +N+L+ + + AK++D G+S+ + + G W A E L + T Sbjct: 965 DLAARNILVGE--NYVAKIADFGLSRGQEVYVKKT----MGRLPVRWMAIESLNYSVYTT 1018 Query: 561 AMDLFSLGCLIFYCITKGKHPF-----GEYYERDINIINGHFDLFVVDHIPEAVHLISLL 725 D++S G L++ ++ G P+ E YE+ + G+ ++ E L+ Sbjct: 1019 NSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEK---LPQGYRLEKPLNCDDEVYDLMRQC 1075 Query: 726 LQPKPDERPT 755 + KP ERP+ Sbjct: 1076 WREKPYERPS 1085
>A4K2P5:STK4_COLGU Serine/threonine-protein kinase 4 - Colobus guereza| (Black-and-white colobus monkey) Length = 487 Score = 70.9 bits (172), Expect = 1e-11 Identities = 63/258 (24%), Positives = 117/258 (45%), Gaps = 13/258 (5%) Frame = +3 Query: 45 GREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLAD 221 G+ VA+K++ + S KEI + D P++V+ YG + ++I +E C Sbjct: 53 GQIVAIKQVPVESDLQEIIKEISIMQQCD-SPHVVKYYGSYFKNTDLWIVMEYCGAG--- 108 Query: 222 LIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNV 401 S SD+ ++ + T+D ++ +++ + G+ +LH + IHRD+K N+ Sbjct: 109 --------SVSDIIRLRNKTLTED-----EIATVLQSTLKGLEYLHFMRKIHRDIKAGNI 155 Query: 402 LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSL 581 L++ EG AKL+D G++ +L + M+ T G+ W APE ++ D++SL Sbjct: 156 LLNTEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEVIQEIGYNCVADIWSL 210 Query: 582 GCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP------------EAVHLISLL 725 G + +GK P+ + I+ +F++ P + Sbjct: 211 GITAIE-MAEGKPPYAD--------IHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQC 261 Query: 726 LQPKPDERPTAMYAINHP 779 L P++R TA + HP Sbjct: 262 LVKSPEQRATATQLLQHP 279
>Q6IP06:STK3_XENLA Serine/threonine-protein kinase 3 - Xenopus laevis (African clawed| frog) Length = 493 Score = 70.9 bits (172), Expect = 1e-11 Identities = 69/274 (25%), Positives = 126/274 (45%), Gaps = 15/274 (5%) Frame = +3 Query: 3 KGSNGTVVFEGSY--DGREVAVKRL-LRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDD 173 +GS G+V F+ + G+ VA+K++ + S KEI + D +V+ YG + Sbjct: 34 EGSYGSV-FKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSH-YVVKYYGSYFKN 91 Query: 174 NFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVH 353 ++I +E C S SD+ ++ + T+D ++ ++R + G+ + Sbjct: 92 TDLWIVMEYCGAG-----------SVSDIIRLRNKTLTED-----EIATILRSTLKGLEY 135 Query: 354 LHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPE 533 LH + IHRD+K N+L++ EG AKL+D G++ +L + M+ T G+ W APE Sbjct: 136 LHFMRKIHRDIKAGNILLNTEG--HAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPE 190 Query: 534 QLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIP----- 698 ++ D++SLG + + +GK P+ + I+ +F++ P Sbjct: 191 VIQEIGYNCVADIWSLG-ITSIEMAEGKPPYAD--------IHPMRAIFMIPTNPPPTFR 241 Query: 699 -------EAVHLISLLLQPKPDERPTAMYAINHP 779 E + L P++R TA + HP Sbjct: 242 KPELWTDEFTDFVKKCLVKNPEQRATATQLLQHP 275
>Q4WHP3:STE20_ASPFU Serine/threonine-protein kinase ste20 - Aspergillus fumigatus| (Sartorya fumigata) Length = 815 Score = 70.9 bits (172), Expect = 1e-11 Identities = 49/161 (30%), Positives = 85/161 (52%), Gaps = 4/161 (2%) Frame = +3 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLS 488 Q+ + R+ + G+ HLHS G+IHRD+K N+L+S +G++ KL+D G ++ + S + Sbjct: 629 QIAAVCRETLNGLQHLHSKGVIHRDIKSDNILLSLDGNI--KLTDFGFCAQIND---SQN 683 Query: 489 HHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-GEYYERDINIING 665 T G+ W APE + R R +D++SLG + I +G+ P+ E R + +I Sbjct: 684 KRNTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMI-EGEPPYLTESPLRALYLIAT 742 Query: 666 HFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 + + D P + L L+ P++R +A + HP Sbjct: 743 NGTPTIKDEHNLSPVFRDFLHLALKVDPEKRASAHDLLMHP 783
>Q12706:PSK1_SCHPO Serine/threonine-protein kinase psk1 - Schizosaccharomyces pombe| (Fission yeast) Length = 436 Score = 70.9 bits (172), Expect = 1e-11 Identities = 62/215 (28%), Positives = 99/215 (46%), Gaps = 7/215 (3%) Frame = +3 Query: 3 KGSNGTVVF-EGSYDGREVAVKRLLRSHTDIAQKEIQN------LIASDRDPNIVRLYGC 161 +GS G V+ + GR A K+L ++ + K ++ ++ R P I RLY Sbjct: 99 RGSYGKVLLVKQKNTGRLFAQKQLKKASIVLRAKGLEQTKNERQILEEVRHPFICRLYYA 158 Query: 162 DQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVA 341 QD + +Y+ L+ ++ ++ L Q LP + ++ Sbjct: 159 FQDHDRLYLILQ-----------------YAPGGELFSHLAEQRMLPEDVVAFYTAELTL 201 Query: 342 GIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGW 521 ++HLH LGI++RDLKP+N L+ EG + L+D G+SK + S GT + Sbjct: 202 ALIHLHKLGIVYRDLKPENCLLDAEGHI--LLTDFGLSKVAENGADCRSFVGT----EEY 255 Query: 522 QAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF 626 APE L A+D +S+G LIF +T G PF Sbjct: 256 CAPEILLEQPYDHAVDWWSMGILIFDLLT-GSPPF 289
>Q496M5:PLK5_HUMAN Serine/threonine-protein kinase PLK5 - Homo sapiens (Human)| Length = 552 Score = 70.9 bits (172), Expect = 1e-11 Identities = 66/232 (28%), Positives = 104/232 (44%), Gaps = 13/232 (5%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERC-HCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPS 305 R NIV +G D + VY+ LE C SLA +++ + L Sbjct: 86 RPRNIVAFHGHFADRDHVYMVLEYCSRQSLAHVLR------------------ARQILTE 127 Query: 306 PQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSL 485 P++ +R +V+G+ +LH I+HRDLK N ++K ++ K+ D+G++ ++ Sbjct: 128 PEVRYYLRGLVSGLRYLHQRCILHRDLKLSNFFLNK--NMEVKIGDLGLAAKVGPGGRC- 184 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-----GEYYERDI 650 H G+ + APE + R + D+++LGC I Y + G PF E Y+ Sbjct: 185 --HRVLCGTPNFLAPEVVSRNGHS-CQDIWALGC-IMYTVLTGTPPFMASPLSEMYQ--- 237 Query: 651 NIINGHFDLFVVDHIPEAVH-------LISLLLQPKPDERPTAMYAINHPLF 785 NI GH+ PE H LI LL P P ERP+ + + F Sbjct: 238 NIREGHY--------PEPAHLSANARRLIVHLLAPNPAERPSLDHLLQDDFF 281
>Q60806:PLK3_MOUSE Serine/threonine-protein kinase PLK3 - Mus musculus (Mouse)| Length = 631 Score = 70.9 bits (172), Expect = 1e-11 Identities = 68/256 (26%), Positives = 114/256 (44%), Gaps = 6/256 (2%) Frame = +3 Query: 36 SYDGREVAVKRLLRSHTDIAQKEIQNLIASDRD---PNIVRLYGCDQDDNFVYISLERCH 206 +Y + + R+ + H +++I N I RD +IVR +D + +YI LE C Sbjct: 88 AYAVKVIPQSRVAKPHQ---REKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCS 144 Query: 207 CSLADLIQQHTDPSFSDVEKIDVELW-TQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRD 383 K +W + L P++ +R +++G+ +LH GI+HRD Sbjct: 145 ------------------RKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 186 Query: 384 LKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRA 563 LK N I+ ++ K+ D G++ RL+ T G+ + APE L R Sbjct: 187 LKLGNFFIT--DNMELKVGDFGLAARLEPPE---QRKKTICGTPNYVAPEVLLRQGHGPE 241 Query: 564 MDLFSLGCLIFYCITKGKHPF--GEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPK 737 D++SLGC + Y + G PF + E I H+ L +P A L++ +L+ Sbjct: 242 ADVWSLGC-VMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLP-ARQLLAAILRAS 299 Query: 738 PDERPTAMYAINHPLF 785 P +RP+ + H F Sbjct: 300 PRDRPSIEQILRHDFF 315
>P28178:PK2_DICDI Protein kinase 2 - Dictyostelium discoideum (Slime mold)| Length = 479 Score = 70.9 bits (172), Expect = 1e-11 Identities = 68/261 (26%), Positives = 125/261 (47%), Gaps = 12/261 (4%) Frame = +3 Query: 3 KGSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQN------LIASDRDPNIVRLYGCD 164 KGS G V+ ++ ++LR IA+K++ + ++ P IV L+ Sbjct: 161 KGSFGKVMQVKKKGEDKIFAMKVLRKDAIIARKQVNHTKSEKTILQCISHPFIVNLHYAF 220 Query: 165 QDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAG 344 Q + +Y+ L+ F + ++ L + P++ ++V+ Sbjct: 221 QTKDKLYMVLD-----------------FVNGGELFFHLKREGRFSEPRVKIYAAEIVSA 263 Query: 345 IVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQ 524 + HLH I++RDLKP+N+L+ EG + ++D G+SK+++ + + GT + Sbjct: 264 LDHLHKQDIVYRDLKPENILLDSEGHIC--ITDFGLSKKIETTDGTFTFCGT----PEYL 317 Query: 525 APEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDIN-----IINGHFDLFVVD 689 APE L A+D +SLG L++ +T G PF Y ++++ I+NG +L + Sbjct: 318 APEVLNGHGHGCAVDWWSLGTLLYEMLT-GLPPF---YSQNVSTMYQKILNG--ELKIPT 371 Query: 690 HI-PEAVHLISLLLQPKPDER 749 +I PEA L+ LL + D+R Sbjct: 372 YISPEAKSLLEGLLTREVDKR 392
>Q9Z1J2:NEK4_MOUSE Serine/threonine-protein kinase Nek4 - Mus musculus (Mouse)| Length = 792 Score = 70.9 bits (172), Expect = 1e-11 Identities = 75/275 (27%), Positives = 126/275 (45%), Gaps = 16/275 (5%) Frame = +3 Query: 3 KGSNGTVVF-EGSYDGREVAVKRL-LRSHTD----IAQKEIQNLIASDRDPNIVRLY-GC 161 +GS G V + DG++ +K+L LR+ + A++E Q L++ + PNIV Sbjct: 14 RGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQ-LLSQLKHPNIVTYKESW 72 Query: 162 DQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDG--LPSPQLLKLMRDV 335 + D +YI + C DL ++ L Q G LP Q+++ + Sbjct: 73 EGGDGLLYIVMG--FCEGGDLYRK---------------LKEQKGQLLPESQVVEWFVQI 115 Query: 336 VAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQE--DMSSLSHHGTGYG 509 + +LH I+HRDLK QNV +++ + K+ D+GI++ L+ DM+S T G Sbjct: 116 AMALQYLHEKHILHRDLKTQNVFLTRTNII--KVGDLGIARVLENHGDMAS-----TLIG 168 Query: 510 SSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDIN-----IINGHFD 674 + + +PE D+++LGC ++ T KH F +D+N II G Sbjct: 169 TPYYMSPELFSNKPYNYKSDVWALGCCVYEMATL-KHAFN---AKDMNSLVYRIIEGKLP 224 Query: 675 LFVVDHIPEAVHLISLLLQPKPDERPTAMYAINHP 779 + E LI +L +P+ERP+ + P Sbjct: 225 PMPKVYSTELAELIRTMLSRRPEERPSVRSILRQP 259
>P18652:KS6AA_CHICK Ribosomal protein S6 kinase 2 alpha - Gallus gallus (Chicken)| Length = 752 Score = 70.9 bits (172), Expect = 1e-11 Identities = 56/195 (28%), Positives = 96/195 (49%), Gaps = 3/195 (1%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQ 230 +V K L+ + K ++++A P +V+L+ Q + +Y+ L+ DL Sbjct: 112 KVLKKATLKVRDRVRTKIERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGG--DLFT 169 Query: 231 QHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLIS 410 + + E DV+ + + ++ G+ HLHSLGII+RDLKP+N+L+ Sbjct: 170 RLSKEVMFTEE--DVKFY-------------LAELALGLDHLHSLGIIYRDLKPENILLD 214 Query: 411 KEGSLSAKLSDMGISKRLQEDMSSLSHHGTGY---GSSGWQAPEQLRRASQTRAMDLFSL 581 +EG + KL+D G+SK ++ H Y G+ + APE + R + + D +S Sbjct: 215 EEGHI--KLTDFGLSK------EAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSY 266 Query: 582 GCLIFYCITKGKHPF 626 G L+F +T G PF Sbjct: 267 GVLMFEMLT-GSLPF 280 Score = 69.7 bits (169), Expect = 3e-11 Identities = 68/257 (26%), Positives = 112/257 (43%), Gaps = 14/257 (5%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQ 230 E AVK + +S D ++ EI+ L+ + PNI+ L D +VY+ E Sbjct: 460 EYAVKVIDKSKRDPSE-EIEILLRYGQHPNIITLKDVYDDGKYVYLVTELMRGG------ 512 Query: 231 QHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLIS 410 E +D ++ Q + ++ + + +LHS G++HRDLKP N+L Sbjct: 513 ----------ELLD-KILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKPSNILYV 561 Query: 411 KEGS--LSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 E S ++ D G +K+L+ + L T ++ + APE L+R D++SLG Sbjct: 562 DESGNPESIRICDFGFAKQLRAENGLLM---TPCYTANFVAPEVLKRQGYDEGCDIWSLG 618 Query: 585 CLIFYCITKGKHPFG--------EYYER----DINIINGHFDLFVVDHIPEAVHLISLLL 728 L+ Y + G PF E R ++ G++D A L+S +L Sbjct: 619 VLL-YTMLAGCTPFANGPSDTPEEILTRIGGGKFSVNGGNWDTI----SDVAKDLVSKML 673 Query: 729 QPKPDERPTAMYAINHP 779 P +R TA + HP Sbjct: 674 HVDPHQRLTAKQVLQHP 690
>P42818:KPK1_ARATH Serine/threonine-protein kinase AtPK1/AtPK6 - Arabidopsis thaliana| (Mouse-ear cress) Length = 465 Score = 70.9 bits (172), Expect = 1e-11 Identities = 49/143 (34%), Positives = 81/143 (56%), Gaps = 3/143 (2%) Frame = +3 Query: 330 DVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYG 509 ++V+ + HLH GI+HRDLKP+N+L+ +G + L+D G++K +E+ S S GT Sbjct: 240 EIVSAVSHLHEKGIMHRDLKPENILMDTDGHV--MLTDFGLAKEFEENTRSNSMCGT--- 294 Query: 510 SSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-GEYYERDINIINGHFDL--F 680 + + APE +R +A D +S+G L++ +T GK PF G + I+ L F Sbjct: 295 -TEYMAPEIVRGKGHDKAADWWSVGILLYEMLT-GKPPFLGSKGKIQQKIVKDKIKLPQF 352 Query: 681 VVDHIPEAVHLISLLLQPKPDER 749 + + EA ++ LLQ +P+ R Sbjct: 353 LSN---EAHAILKGLLQKEPERR 372
>Q6DGS3:KCC2D_DANRE Calcium/calmodulin-dependent protein kinase type II delta chain -| Danio rerio (Zebrafish) (Brachydanio rerio) Length = 493 Score = 70.9 bits (172), Expect = 1e-11 Identities = 61/223 (27%), Positives = 105/223 (47%), Gaps = 6/223 (2%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 + PNIVRL+ ++ F Y+ + DL+ F D+ ++ Sbjct: 68 KHPNIVRLHDSISEEGFHYL--------VFDLVTG--GELFEDIV-------AREYYSEA 110 Query: 309 QLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLI-SKEGSLSAKLSDMGISKRLQEDMSSL 485 ++ ++ + H H GI+HRDLKP+N+L+ SK + KL+D G++ +Q D + Sbjct: 111 DASHCIQQILESVHHCHVNGIVHRDLKPENLLLASKMKGAAVKLADFGLAIEVQGDQQAW 170 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NII 659 G+ G+ +PE LR+ + +D+++ G +I Y + G PF + + + I Sbjct: 171 FGFA---GTPGYLSPEVLRKDPYGKPVDMWACG-VILYILLVGYPPFWDEDQHRLYQQIK 226 Query: 660 NGHFDLFVVDH---IPEAVHLISLLLQPKPDERPTAMYAINHP 779 G +D + PEA LI+ +L P +R TA A HP Sbjct: 227 AGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEAPKHP 269
>Q8WTQ7:GRK7_HUMAN G protein-coupled receptor kinase 7 precursor - Homo sapiens| (Human) Length = 553 Score = 70.9 bits (172), Expect = 1e-11 Identities = 40/118 (33%), Positives = 69/118 (58%), Gaps = 1/118 (0%) Frame = +3 Query: 294 GLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQED 473 GL +++ + G++HLH LGI++RD+KP+NVL+ G + +LSD+G++ ++ Sbjct: 287 GLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLG--NCRLSDLGLAVEMKGG 344 Query: 474 MSSLSHHGTGYGSSGWQAPEQL-RRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYER 644 GT +G+ APE L + S + +D F++GC I Y + G+ PF +Y E+ Sbjct: 345 KPITQRAGT----NGYMAPEILMEKVSYSYPVDWFAMGCSI-YEMVAGRTPFKDYKEK 397
>Q91735:EPHB3_XENLA Ephrin type-B receptor 3 precursor - Xenopus laevis (African clawed| frog) Length = 974 Score = 70.9 bits (172), Expect = 1e-11 Identities = 57/229 (24%), Positives = 105/229 (45%), Gaps = 6/229 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PNI+RL G V I E D Sbjct: 638 VAIKTLKAGYTEQQRRDFLGEASIMGQFDHPNIIRLEGVVTRSRPVMILTEFMENGALDS 697 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + +G+ +L + +HRDL +N+L Sbjct: 698 FLRMNDGQFTVI----------------QLVGILRGIASGMKYLSEMNYVHRDLAARNIL 741 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ L+ S ++ G W APE + T A D++S Sbjct: 742 VN--SNLVCKVSDFGLSRFLENSRSDPTYTSALGGKIPIRWTAPEAISYRKFTSASDVWS 799 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL 722 G +++ ++ G+ P+ + +D IN I + L P A+H + L Sbjct: 800 YGIVMWEVMSYGERPYWDMSNQDVINAIEQDYRLPPPMDCPSALHQLML 848
>Q9FNE1:CRK42_ARATH Cysteine-rich receptor-like protein kinase 42 precursor -| Arabidopsis thaliana (Mouse-ear cress) Length = 651 Score = 70.9 bits (172), Expect = 1e-11 Identities = 60/203 (29%), Positives = 98/203 (48%), Gaps = 6/203 (2%) Frame = +3 Query: 3 KGSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQ--NLIASDRDPNIVRLYGCDQDDN 176 +G NGTV +G+ VAVKRL+ + D ++ NLI+ + N+V+L GC + Sbjct: 323 QGGNGTVFLGILPNGKNVAVKRLVFNTRDWVEEFFNEVNLISGIQHKNLVKLLGCSIEGP 382 Query: 177 FVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHL 356 + E + + D D + V W+ Q L ++ G+ +L Sbjct: 383 ESLLVYEY-------VPNKSLDQFLFDESQSKVLNWS-------QRLNIILGTAEGLAYL 428 Query: 357 HS---LGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGY-GSSGWQ 524 H + IIHRD+K NVL+ + L+ K++D G+++ D + LS TG G+ G+ Sbjct: 429 HGGSPVRIIHRDIKTSNVLL--DDQLNPKIADFGLARCFGLDKTHLS---TGIAGTLGYM 483 Query: 525 APEQLRRASQTRAMDLFSLGCLI 593 APE + R T D++S G L+ Sbjct: 484 APEYVVRGQLTEKADVYSFGVLV 506
>O55076:CDK2_CRIGR Cell division protein kinase 2 - Cricetulus griseus (Chinese| hamster) Length = 298 Score = 70.9 bits (172), Expect = 1e-11 Identities = 57/195 (29%), Positives = 98/195 (50%), Gaps = 6/195 (3%) Frame = +3 Query: 45 GREVAVKRL-LRSHTD----IAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHC 209 G VA+K++ L + T+ A +EI +L+ PNIV+L +N +Y+ E H Sbjct: 27 GEVVALKKIRLDTETEGVPSTAIREI-SLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ 85 Query: 210 SLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLK 389 L F D + G+P P + + ++ G+ HS ++HRDLK Sbjct: 86 DLK---------KFMDASAVT-------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLK 129 Query: 390 PQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRAS-QTRAM 566 PQN+LI+ EGS+ KL+D G+++ + + +H + ++APE L + A+ Sbjct: 130 PQNLLINAEGSI--KLADFGLARAFGVPVRTYTHEVV---TLWYRAPEILLGCKYYSTAV 184 Query: 567 DLFSLGCLIFYCITK 611 D++SLGC+ +T+ Sbjct: 185 DIWSLGCIFAEMVTR 199
>P10506:BYR1_SCHPO Protein kinase byr1 - Schizosaccharomyces pombe (Fission yeast)| Length = 340 Score = 70.9 bits (172), Expect = 1e-11 Identities = 50/162 (30%), Positives = 78/162 (48%), Gaps = 1/162 (0%) Frame = +3 Query: 129 RDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSP 308 R P IV YG Q N + + +E C D I + P +P Sbjct: 118 RSPYIVGFYGAFQYKNNISLCMEYMDCGSLDAILREGGP-----------------IPLD 160 Query: 309 QLLKLMRDVVAGIVHLHS-LGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSL 485 L K++ +V G+++L++ L IIHRDLKP NV+++ G + KL D G+S L ++ Sbjct: 161 ILGKIINSMVKGLIYLYNVLHIIHRDLKPSNVVVNSRGEI--KLCDFGVSGELVNSVAQ- 217 Query: 486 SHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITK 611 T G+S + +PE++R T D++SLG I T+ Sbjct: 218 ----TFVGTSTYMSPERIRGGKYTVKSDIWSLGISIIELATQ 255
>Q06806:TIE1_MOUSE Tyrosine-protein kinase receptor Tie-1 precursor - Mus musculus| (Mouse) Length = 1134 Score = 70.5 bits (171), Expect = 2e-11 Identities = 57/198 (28%), Positives = 97/198 (48%), Gaps = 10/198 (5%) Frame = +3 Query: 81 HTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERC-HCSLADLIQQ----HTDP 245 H D A E++ L PNI+ L G ++ ++YI++E + +L D +++ TDP Sbjct: 877 HRDFAG-ELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDP 935 Query: 246 SFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSL 425 +F+ E T L S QLL+ D G+ +L IHRDL +NVL+ + +L Sbjct: 936 AFAR------EHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGE--NL 987 Query: 426 SAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCI 605 ++K++D G+S+ + + G W A E L + T D++S G L++ + Sbjct: 988 ASKIADFGLSRGEEVYVKKT----MGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIV 1043 Query: 606 TKGKHPF-----GEYYER 644 + G P+ E YE+ Sbjct: 1044 SLGGTPYCGMTCAELYEK 1061
>Q06805:TIE1_BOVIN Tyrosine-protein kinase receptor Tie-1 precursor - Bos taurus| (Bovine) Length = 1136 Score = 70.5 bits (171), Expect = 2e-11 Identities = 57/198 (28%), Positives = 97/198 (48%), Gaps = 10/198 (5%) Frame = +3 Query: 81 HTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERC-HCSLADLIQQ----HTDP 245 H D A E++ L PNI+ L G ++ ++YI++E + +L D +++ TDP Sbjct: 879 HRDFAG-ELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDP 937 Query: 246 SFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSL 425 +F+ E T L S QLL+ D G+ +L IHRDL +NVL+ + +L Sbjct: 938 AFAR------EHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGE--NL 989 Query: 426 SAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCI 605 ++K++D G+S+ + + G W A E L + T D++S G L++ + Sbjct: 990 ASKIADFGLSRGEEVYVKKT----MGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIV 1045 Query: 606 TKGKHPF-----GEYYER 644 + G P+ E YE+ Sbjct: 1046 SLGGTPYCGMTCAELYEK 1063
>Q99640:PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase - Homo sapiens (Human) Length = 499 Score = 70.5 bits (171), Expect = 2e-11 Identities = 80/273 (29%), Positives = 113/273 (41%), Gaps = 10/273 (3%) Frame = +3 Query: 6 GSNGTVV-FEGSYDGREVAVKRLL---RSHTDIAQK--EIQNLIASDRDPNIVRLYGCDQ 167 GS G V DGR AVKR + R D A+K E+ + + P VRL + Sbjct: 119 GSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWE 178 Query: 168 DDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGI 347 + +Y+ E C SL QQH E W LP Q+ +RD + + Sbjct: 179 EGGILYLQTELCGPSL----QQHC------------EAWGAS-LPEAQVWGYLRDTLLAL 221 Query: 348 VHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTG---YGSSG 518 HLHS G++H D+KP N+ + G KL D G+ + L G G G Sbjct: 222 AHLHSQGLVHLDVKPANIFLGPRG--RCKLGDFGL-------LVELGTAGAGEVQEGDPR 272 Query: 519 WQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHF-DLFVVDHI 695 + APE L + S A D+FSLG I + P G E + G+ F Sbjct: 273 YMAPE-LLQGSYGTAADVFSLGLTILEVACNMELPHGG--EGWQQLRQGYLPPEFTAGLS 329 Query: 696 PEAVHLISLLLQPKPDERPTAMYAINHPLFWSP 794 E ++ ++L+P P R TA + P+ P Sbjct: 330 SELRSVLVMMLEPDPKLRATAEALLALPVLRQP 362
>Q9R011:PLK3_RAT Serine/threonine-protein kinase PLK3 - Rattus norvegicus (Rat)| Length = 615 Score = 70.5 bits (171), Expect = 2e-11 Identities = 68/256 (26%), Positives = 114/256 (44%), Gaps = 6/256 (2%) Frame = +3 Query: 36 SYDGREVAVKRLLRSHTDIAQKEIQNLIASDRD---PNIVRLYGCDQDDNFVYISLERCH 206 +Y + + R+ + H +++I N I RD +IVR +D + +YI LE C Sbjct: 56 AYAVKVIPQSRVAKPHQ---REKIINEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCS 112 Query: 207 CSLADLIQQHTDPSFSDVEKIDVELW-TQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRD 383 K +W + L P++ +R +++G+ +LH GI+HRD Sbjct: 113 ------------------RKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 154 Query: 384 LKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRA 563 LK N I+ ++ K+ D G++ RL+ T G+ + APE L R Sbjct: 155 LKLGNFFIT--DNMELKVGDFGLAARLEPPE---QRKKTICGTPNYVAPEVLLRQGHGPE 209 Query: 564 MDLFSLGCLIFYCITKGKHPF--GEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPK 737 D++SLGC + Y + G PF + E I H+ L +P A L++ +L+ Sbjct: 210 ADVWSLGC-VMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLP-ARQLLAAILRAS 267 Query: 738 PDERPTAMYAINHPLF 785 P +RP+ + H F Sbjct: 268 PRDRPSIEQILRHDFF 283
>P10741:MOS_CHICK Serine/threonine-protein kinase mos - Gallus gallus (Chicken)| Length = 349 Score = 70.5 bits (171), Expect = 2e-11 Identities = 65/230 (28%), Positives = 107/230 (46%), Gaps = 21/230 (9%) Frame = +3 Query: 6 GSNGT-VVFEGSYDGREVAVKRLLRSHTDIAQKEIQNLIASDR----DPNIVRLYGCDQD 170 GS G V++ +Y G VAVK++ +K +N +AS + + N+ RL Q Sbjct: 71 GSGGFGAVYKATYHGVTVAVKQV--------KKSSKNRLASRQSFWAELNVARL----QH 118 Query: 171 DNFV-YISLERC----HCSLADLIQQHT-DPSFSDVEKIDVELWTQD----------GLP 302 DN V ++ C SL +I ++ + + V + W Q L Sbjct: 119 DNVVRVVAASTCAPASQNSLGTIIMEYVGNVTLHHVIYGTRDAWRQGEEEEGGCGRKALS 178 Query: 303 SPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSS 482 + + D+V G+ LHS GI+H DLKP N+LI++ G + K+ D G S+RL+E +S Sbjct: 179 MAEAVCYSCDIVTGLAFLHSQGIVHLDLKPANILITEHG--ACKIGDFGCSQRLEEGLSQ 236 Query: 483 LSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGE 632 H G+ +APE L+ T D++S ++ + + + GE Sbjct: 237 SHHVCQQGGTYTHRAPELLKGERVTAKADIYSFAITLWQIVMREQPYLGE 286
>Q9UBS0:KS6B2_HUMAN Ribosomal protein S6 kinase beta-2 - Homo sapiens (Human)| Length = 482 Score = 70.5 bits (171), Expect = 2e-11 Identities = 75/261 (28%), Positives = 127/261 (48%), Gaps = 12/261 (4%) Frame = +3 Query: 3 KGSNGTVV----FEGSYDGREVAVK-----RLLRSHTDIAQKEIQ-NLIASDRDPNIVRL 152 KG G V +G+ G+ A+K +++R+ D A + N++ S + P IV L Sbjct: 75 KGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVEL 134 Query: 153 YGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRD 332 Q +Y+ LE C + F+ +E+ + L + + Sbjct: 135 AYAFQTGGKLYLILE---CLSGGEL-------FTHLEREGIFL-------EDTACFYLAE 177 Query: 333 VVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGS 512 + + HLHS GII+RDLKP+N+++S +G + KL+D G+ K + +++H T G+ Sbjct: 178 ITLALGHLHSQGIIYRDLKPENIMLSSQGHI--KLTDFGLCKESIHE-GAVTH--TFCGT 232 Query: 513 SGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF-GEYYERDIN-IINGHFDLFVV 686 + APE L R+ RA+D +SLG L++ +T G PF E ++ ++ II G L Sbjct: 233 IEYMAPEILVRSGHNRAVDWWSLGALMYDMLT-GSPPFTAENRKKTMDKIIRGKLAL-PP 290 Query: 687 DHIPEAVHLISLLLQPKPDER 749 P+A L+ L+ P +R Sbjct: 291 YLTPDARDLVKKFLKRNPSQR 311
>P25389:KCC4_YEAST Probable serine/threonine-protein kinase KCC4 - Saccharomyces| cerevisiae (Baker's yeast) Length = 1037 Score = 70.5 bits (171), Expect = 2e-11 Identities = 63/223 (28%), Positives = 106/223 (47%), Gaps = 7/223 (3%) Frame = +3 Query: 135 PNIVRLYGCDQDDNFVYISLERCHCS-LADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQ 311 PN++ LY + +N +Y+ LE L +L+ H LP + Sbjct: 87 PNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGP------------------LPERE 128 Query: 312 LLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSH 491 + R ++ GI + H+LGI+HRDLKP+N+L+ + + K++D G++ LQ D L Sbjct: 129 AINCFRQIIIGISYCHALGIVHRDLKPENLLL--DSFYNIKIADFGMA-ALQTDADLLE- 184 Query: 492 HGTGYGSSGWQAPEQLRRAS-QTRAMDLFSLGCLIFYCITKGKHPF----GEYYERDINI 656 T GS + APE + + A D++S G ++F +T G+ PF G + + + Sbjct: 185 --TSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLT-GRLPFDEENGNVRDLLLKV 241 Query: 657 INGHFDLFVVDHIP-EAVHLISLLLQPKPDERPTAMYAINHPL 782 G F++ I +A LI +L P +R ++HPL Sbjct: 242 QKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHPL 284
>Q00771:KCC1_EMENI Calcium/calmodulin-dependent protein kinase - Emericella nidulans| (Aspergillus nidulans) Length = 414 Score = 70.5 bits (171), Expect = 2e-11 Identities = 51/158 (32%), Positives = 82/158 (51%), Gaps = 6/158 (3%) Frame = +3 Query: 324 MRDVVAGIVHLHSLGIIHRDLKPQNVL-ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT 500 +R V+ + +LH I+HRDLKP+N+L ++++ L+D GI+K L L+ Sbjct: 123 IRQVLDAVNYLHQRNIVHRDLKPENLLYLTRDLDSQLVLADFGIAKMLDNPAEVLTSMA- 181 Query: 501 GYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NIINGH-- 668 GS G+ APE + + +A+D++SLG +I Y + G PF D+ +G Sbjct: 182 --GSFGYAAPEVMLKQGHGKAVDIWSLG-VITYTLLCGYSPFRSENLTDLIEECRSGRVV 238 Query: 669 -FDLFVVDHIPEAVHLISLLLQPKPDERPTAMYAINHP 779 + + D +A I LLQ P +RPT+ A+ HP Sbjct: 239 FHERYWKDVSKDAKDFILSLLQVDPAQRPTSEEALKHP 276
>Q6BVA0:IPL1_DEBHA Spindle assembly checkpoint kinase - Debaryomyces hansenii (Yeast)| (Torulaspora hansenii) Length = 412 Score = 70.5 bits (171), Expect = 2e-11 Identities = 66/216 (30%), Positives = 98/216 (45%), Gaps = 1/216 (0%) Frame = +3 Query: 135 PNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQL 314 P I RLYG D VY+ LE S+ + H + V+ D S + Sbjct: 206 PKISRLYGFFYDHKNVYLILEY---SIHGELYHH----------LKVQRRFNDATASHYI 252 Query: 315 LKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHH 494 + V + +LH+ IIHRD+KP+N+L+S + + KLSD G S ++ SS + Sbjct: 253 YQ----VALALDYLHTKHIIHRDIKPENILLSTDNCI--KLSDFGWS--VKSLPSSSTKR 304 Query: 495 GTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIINGHFD 674 T G+ + PE + +D++SLG L + + GK PF E + D Sbjct: 305 LTICGTLDYLPPEMIESNEHDYTVDIWSLGILCYEFLV-GKPPFEEIDKNSTYKRIAKVD 363 Query: 675 LFVVDHI-PEAVHLISLLLQPKPDERPTAMYAINHP 779 L + + EA LI LLQ P +R T +NHP Sbjct: 364 LKIPSFLSSEATDLILRLLQKSPKKRITLAEVMNHP 399
>P29319:EPHA3_MOUSE Ephrin type-A receptor 3 precursor - Mus musculus (Mouse)| Length = 983 Score = 70.5 bits (171), Expect = 2e-11 Identities = 57/242 (23%), Positives = 107/242 (44%), Gaps = 3/242 (1%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PNI+RL G I E D Sbjct: 650 VAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPEMIVTEYMENGSLDS 709 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + +G+ +L +G +HRDL +N+L Sbjct: 710 FLRKHDAQFTVI----------------QLVGMLRGIASGMKYLSDMGYVHRDLAARNIL 753 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 I+ +L K+SD G+S+ L++D + G W +PE + T A D++S G Sbjct: 754 IN--SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAMSYRKFTSASDVWSYG 811 Query: 585 CLIFYCITKGKHPFGEYYERDINIINGHFDLFVVDHIPEAVHLISLLLQPKPDERPTAMY 764 +++ ++ G+ P+ + +D V+ + E L P P + P A+Y Sbjct: 812 IVLWEVMSYGERPYSQMSNQD-----------VIKAVDERYRL------PPPMDCPAALY 854 Query: 765 AI 770 + Sbjct: 855 QL 856
>Q01389:BCK1_YEAST Serine/threonine-protein kinase BCK1/SLK1/SSP31 - Saccharomyces| cerevisiae (Baker's yeast) Length = 1478 Score = 70.5 bits (171), Expect = 2e-11 Identities = 49/171 (28%), Positives = 88/171 (51%), Gaps = 13/171 (7%) Frame = +3 Query: 306 PQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSL 485 P + L V+ G+ +LHS GI+HRD+K N+L+ ++G K+SD GIS++ ++ S+ Sbjct: 1278 PLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDG--ICKISDFGISRKSKDIYSNS 1335 Query: 486 SHHGTGYGSSGWQAPEQL-RRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINIIN 662 T G+ W APE + + + +D++SLGC++ GK P+ ++ ++ Sbjct: 1336 DM--TMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFA-GKRPWS-----NLEVVA 1387 Query: 663 GHFDLFVVDHIP----EAVHLISLL--------LQPKPDERPTAMYAINHP 779 F + P + + LIS + + P++RPTA ++HP Sbjct: 1388 AMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHP 1438
>Q04736:YES_MOUSE Proto-oncogene tyrosine-protein kinase Yes - Mus musculus (Mouse)| Length = 541 Score = 70.1 bits (170), Expect = 2e-11 Identities = 47/158 (29%), Positives = 80/158 (50%), Gaps = 2/158 (1%) Frame = +3 Query: 297 LPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDM 476 L PQL+ + + G+ ++ + IHRDL+ N+L+ + +L K++D G++ RL ED Sbjct: 366 LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE--NLICKIADFGLA-RLIEDN 422 Query: 477 SSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI-N 653 + G + W APE T D++S G L +TKG+ P+ R++ Sbjct: 423 EYTARQGAKFPIK-WTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLE 481 Query: 654 IINGHFDLFVVDHIPEAVH-LISLLLQPKPDERPTAMY 764 + + + PE++H L++L + PDERPT Y Sbjct: 482 QVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEY 519
>P07947:YES_HUMAN Proto-oncogene tyrosine-protein kinase Yes - Homo sapiens (Human)| Length = 543 Score = 70.1 bits (170), Expect = 2e-11 Identities = 47/158 (29%), Positives = 80/158 (50%), Gaps = 2/158 (1%) Frame = +3 Query: 297 LPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDM 476 L PQL+ + + G+ ++ + IHRDL+ N+L+ + +L K++D G++ RL ED Sbjct: 368 LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE--NLVCKIADFGLA-RLIEDN 424 Query: 477 SSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI-N 653 + G + W APE T D++S G L +TKG+ P+ R++ Sbjct: 425 EYTARQGAKFPIK-WTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLE 483 Query: 654 IINGHFDLFVVDHIPEAVH-LISLLLQPKPDERPTAMY 764 + + + PE++H L++L + PDERPT Y Sbjct: 484 QVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEY 521
>P35590:TIE1_HUMAN Tyrosine-protein kinase receptor Tie-1 precursor - Homo sapiens| (Human) Length = 1138 Score = 70.1 bits (170), Expect = 2e-11 Identities = 57/198 (28%), Positives = 97/198 (48%), Gaps = 10/198 (5%) Frame = +3 Query: 81 HTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERC-HCSLADLIQQ----HTDP 245 H D A E++ L PNI+ L G ++ ++YI++E + +L D +++ TDP Sbjct: 881 HRDFAG-ELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDP 939 Query: 246 SFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVLISKEGSL 425 +F+ E T L S QLL+ D G+ +L IHRDL +NVL+ + +L Sbjct: 940 AFAR------EHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGE--NL 991 Query: 426 SAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLGCLIFYCI 605 ++K++D G+S+ + + G W A E L + T D++S G L++ + Sbjct: 992 ASKIADFGLSRGEEVYVKKT----MGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIV 1047 Query: 606 TKGKHPF-----GEYYER 644 + G P+ E YE+ Sbjct: 1048 SLGGTPYCGMTCAELYEK 1065
>Q9UHD2:TBK1_HUMAN Serine/threonine-protein kinase TBK1 - Homo sapiens (Human)| Length = 729 Score = 70.1 bits (170), Expect = 2e-11 Identities = 54/186 (29%), Positives = 89/186 (47%), Gaps = 6/186 (3%) Frame = +3 Query: 87 DIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEK 266 D+ +E + ++ NIV+L+ +++ + L C L +PS Sbjct: 50 DVQMREFE-VLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS------ 102 Query: 267 IDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL--ISKEGSLSAKLS 440 GLP + L ++RDVV G+ HL GI+HRD+KP N++ I ++G KL+ Sbjct: 103 ------NAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLT 156 Query: 441 DMGISKRLQEDMSSLSHHGT-GYGSSGWQAPEQLRRASQTR---AMDLFSLGCLIFYCIT 608 D G ++ L++D +S +GT Y LR+ Q + +DL+S+G + FY Sbjct: 157 DFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIG-VTFYHAA 215 Query: 609 KGKHPF 626 G PF Sbjct: 216 TGSLPF 221
>Q99KH8:STK24_MOUSE Serine/threonine-protein kinase 24 - Mus musculus (Mouse)| Length = 431 Score = 70.1 bits (170), Expect = 2e-11 Identities = 67/288 (23%), Positives = 124/288 (43%), Gaps = 8/288 (2%) Frame = +3 Query: 3 KGSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQNL------IASDRDPNIVRLYGCD 164 KGS G V F+G D R V + + A+ EI+++ ++ P + + YG Sbjct: 32 KGSFGEV-FKG-IDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSY 89 Query: 165 QDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAG 344 D ++I +E A ++L L Q+ ++R+++ G Sbjct: 90 LKDTKLWIIMEYLGGGSA------------------LDLLEPGPLDEIQIATILREILKG 131 Query: 345 IVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQ 524 + +LHS IHRD+K NVL+S+ G + KL+D G++ +L + T G+ W Sbjct: 132 LDYLHSEKKIHRDIKAANVLLSEHGEV--KLADFGVAGQLTDTQIK---RNTFVGTPFWM 186 Query: 525 APEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINII--NGHFDLFVVDHIP 698 APE +++++ D++SLG + KG+ P E + + + + ++ Sbjct: 187 APEVIKQSAYDSKADIWSLGITAIE-LAKGEPPHSELHPMKVLFLIPKNNPPTLEGNYSK 245 Query: 699 EAVHLISLLLQPKPDERPTAMYAINHPLFWSPELRLLFLRDTSDRIEK 842 + L +P RPTA + H + +L + DR ++ Sbjct: 246 PLKEFVEACLNKEPSFRPTAKELLKHKFIIRNAKKTSYLTELIDRYKR 293
>Q9Y6E0:STK24_HUMAN Serine/threonine-protein kinase 24 - Homo sapiens (Human)| Length = 443 Score = 70.1 bits (170), Expect = 2e-11 Identities = 66/288 (22%), Positives = 124/288 (43%), Gaps = 8/288 (2%) Frame = +3 Query: 3 KGSNGTVVFEGSYDGREVAVKRLLRSHTDIAQKEIQNL------IASDRDPNIVRLYGCD 164 KGS G V F+G D R V + + A+ EI+++ ++ P + + YG Sbjct: 44 KGSFGEV-FKG-IDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSY 101 Query: 165 QDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAG 344 D ++I +E A ++L L Q+ ++R+++ G Sbjct: 102 LKDTKLWIIMEYLGGGSA------------------LDLLEPGPLDETQIATILREILKG 143 Query: 345 IVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQ 524 + +LHS IHRD+K NVL+S+ G + KL+D G++ +L + T G+ W Sbjct: 144 LDYLHSEKKIHRDIKAANVLLSEHGEV--KLADFGVAGQLTDTQIK---RNTFVGTPFWM 198 Query: 525 APEQLRRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDINII--NGHFDLFVVDHIP 698 APE +++++ D++SLG + +G+ P E + + + + ++ Sbjct: 199 APEVIKQSAYDSKADIWSLGITAIE-LARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSK 257 Query: 699 EAVHLISLLLQPKPDERPTAMYAINHPLFWSPELRLLFLRDTSDRIEK 842 + L +P RPTA + H + +L + DR ++ Sbjct: 258 PLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKR 305
>P54744:PKNB_MYCLE Probable serine/threonine-protein kinase pknB - Mycobacterium| leprae Length = 622 Score = 70.1 bits (170), Expect = 2e-11 Identities = 58/214 (27%), Positives = 101/214 (47%), Gaps = 22/214 (10%) Frame = +3 Query: 51 EVAVKRLLRSHTDIAQKEIQNLIASD-----------------RDPNIVRLYGCDQDDNF 179 EV + R +R H D+A K ++ +A D P+IV +Y + + Sbjct: 24 EVHLARDIRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPSIVAVYDTGEAETS 83 Query: 180 V----YISLERCH-CSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAG 344 YI +E +L D++ HTD +P Q ++++ D Sbjct: 84 AGPLPYIVMEYVDGATLRDIV--HTDGP----------------MPPQQAIEIVADACQA 125 Query: 345 IVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQ 524 + H GIIHRD+KP N++IS ++ K+ D GI++ + D +S++ G++ + Sbjct: 126 LNFSHQNGIIHRDVKPANIMISATNAV--KVMDFGIARAI-ADSTSVTQTAAVIGTAQYL 182 Query: 525 APEQLRRASQTRAMDLFSLGCLIFYCITKGKHPF 626 +PEQ R S D++SLGC+++ +T G+ PF Sbjct: 183 SPEQARGDSVDARSDVYSLGCVLYEILT-GEPPF 215
>Q8TD19:NEK9_HUMAN Serine/threonine-protein kinase Nek9 - Homo sapiens (Human)| Length = 979 Score = 70.1 bits (170), Expect = 2e-11 Identities = 62/249 (24%), Positives = 111/249 (44%), Gaps = 4/249 (1%) Frame = +3 Query: 48 REVAVKRLLRSHTDIAQKEIQNLIASDRDPNIVRLYGCDQDDNFVYISLERCHC-SLADL 224 +EV + RL A EI L D NI+ Y D+ + I LE C+ +L D Sbjct: 81 KEVDLTRLSEKERRDALNEIVILALLQHD-NIIAYYNHFMDNTTLLIELEYCNGGNLYDK 139 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 I + D F + ++ +W + +V+ + +H GI+HRD+K N+ Sbjct: 140 ILRQKDKLFEE----EMVVW------------YLFQIVSAVSCIHKAGILHRDIKTLNIF 183 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDLFSLG 584 ++K + KL D G++K+L + S T G+ + +PE + D++++G Sbjct: 184 LTKANLI--KLGDYGLAKKLNSEYSMAE---TLVGTPYYMSPELCQGVKYNFKSDIWAVG 238 Query: 585 CLIFYCIT-KGKHPFGEYYERDINIING--HFDLFVVDHIPEAVHLISLLLQPKPDERPT 755 C+IF +T K + I+ G ++ + E + ++ L P++RPT Sbjct: 239 CVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPT 298 Query: 756 AMYAINHPL 782 A ++ PL Sbjct: 299 ADELLDRPL 307
>Q1HKZ5:M3K13_MOUSE Mitogen-activated protein kinase kinase kinase 13 - Mus musculus| (Mouse) Length = 959 Score = 70.1 bits (170), Expect = 2e-11 Identities = 72/262 (27%), Positives = 119/262 (45%), Gaps = 5/262 (1%) Frame = +3 Query: 6 GSNGTVVFEGSYDGREVAVKRLL-RSHTDIAQKEIQNLIASDRDPNIVRLYG-CDQDDNF 179 G+ G V F G + EVA+K++ ++ TDI K ++ L + PNI+ G C Q + Sbjct: 176 GAQGAV-FLGKFRAEEVAIKKVREQNETDI--KHLRKL----KHPNIIAFKGVCTQAPCY 228 Query: 180 VYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLH 359 I H L ++++ KI L L+ + +G+ +LH Sbjct: 229 CIIMEYCAHGQLYEVLRAG--------RKITPRL----------LVDWSTGIASGMNYLH 270 Query: 360 SLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQL 539 IIHRDLK NVL++ ++ K+SD G SK L + + +S GT W APE + Sbjct: 271 LHKIIHRDLKSPNVLVTHTDAV--KISDFGTSKELSDKSTKMSFAGT----VAWMAPEVI 324 Query: 540 RRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NIINGHFDLFVVDHIPEAVH- 710 R + +D++S G +++ +T G+ P+ + I + + L V P+ Sbjct: 325 RNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 383 Query: 711 LISLLLQPKPDERPTAMYAINH 776 L+ Q KP RP+ + H Sbjct: 384 LMKQTWQSKPRNRPSFRQTLMH 405
>O43283:M3K13_HUMAN Mitogen-activated protein kinase kinase kinase 13 - Homo sapiens| (Human) Length = 966 Score = 70.1 bits (170), Expect = 2e-11 Identities = 72/262 (27%), Positives = 119/262 (45%), Gaps = 5/262 (1%) Frame = +3 Query: 6 GSNGTVVFEGSYDGREVAVKRLL-RSHTDIAQKEIQNLIASDRDPNIVRLYG-CDQDDNF 179 G+ G V F G + EVA+K++ ++ TDI K ++ L + PNI+ G C Q + Sbjct: 177 GAQGAV-FLGKFRAEEVAIKKVREQNETDI--KHLRKL----KHPNIIAFKGVCTQAPCY 229 Query: 180 VYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLH 359 I H L ++++ KI L L+ + +G+ +LH Sbjct: 230 CIIMEYCAHGQLYEVLRAG--------RKITPRL----------LVDWSTGIASGMNYLH 271 Query: 360 SLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQL 539 IIHRDLK NVL++ ++ K+SD G SK L + + +S GT W APE + Sbjct: 272 LHKIIHRDLKSPNVLVTHTDAV--KISDFGTSKELSDKSTKMSFAGT----VAWMAPEVI 325 Query: 540 RRASQTRAMDLFSLGCLIFYCITKGKHPFGEYYERDI--NIINGHFDLFVVDHIPEAVH- 710 R + +D++S G +++ +T G+ P+ + I + + L V P+ Sbjct: 326 RNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 384 Query: 711 LISLLLQPKPDERPTAMYAINH 776 L+ Q KP RP+ + H Sbjct: 385 LMKQTWQSKPRNRPSFRQTLMH 406
>Q9R0T8:IKKE_MOUSE Inhibitor of nuclear factor kappa-B kinase subunit epsilon - Mus| musculus (Mouse) Length = 717 Score = 70.1 bits (170), Expect = 2e-11 Identities = 54/173 (31%), Positives = 84/173 (48%), Gaps = 10/173 (5%) Frame = +3 Query: 138 NIVRLYGCDQDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLL 317 NIV+L+ ++ L +CS L+ DP GL + L Sbjct: 66 NIVKLFAVEETGGSRQKVLIMEYCSSGSLLSVLEDPE------------NTFGLSEEEFL 113 Query: 318 KLMRDVVAGIVHLHSLGIIHRDLKPQNV--LISKEGSLSAKLSDMGISKRLQEDMSSLSH 491 ++R VVAG+ HL GI+HRD+KP N+ L+ +EG KLSD G +++L +D +S Sbjct: 114 VVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDDDEKFVS- 172 Query: 492 HGTGYGSSGWQAPEQLRRA----SQTRA----MDLFSLGCLIFYCITKGKHPF 626 YG+ + P+ RA Q +A +DL+S+G +++ T G PF Sbjct: 173 ---VYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAAT-GSLPF 221
>Q14164:IKKE_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit epsilon - Homo| sapiens (Human) Length = 716 Score = 70.1 bits (170), Expect = 2e-11 Identities = 60/208 (28%), Positives = 98/208 (47%), Gaps = 14/208 (6%) Frame = +3 Query: 45 GREVAVKRLLRSHTDIAQKEIQ----NLIASDRDPNIVRLYGCDQDDNFVYISLERCHCS 212 G VAVK + + + + +E+Q ++ NIV+L+ ++ L +CS Sbjct: 32 GELVAVK-VFNTTSYLRPREVQVREFEVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCS 90 Query: 213 LADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKP 392 L+ P GLP + L ++R VVAG+ HL GI+HRD+KP Sbjct: 91 SGSLLSVLESPE------------NAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKP 138 Query: 393 QNV--LISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRA----SQ 554 N+ L+ +EG KL+D G ++ L +D +S YG+ + P+ RA Q Sbjct: 139 GNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVS----VYGTEEYLHPDMYERAVLRKPQ 194 Query: 555 TRA----MDLFSLGCLIFYCITKGKHPF 626 +A +DL+S+G +++ T G PF Sbjct: 195 QKAFGVTVDLWSIGVTLYHAAT-GSLPF 221
>Q07498:EPHB3_CHICK Ephrin type-B receptor 3 - Gallus gallus (Chicken)| Length = 988 Score = 70.1 bits (170), Expect = 2e-11 Identities = 56/229 (24%), Positives = 107/229 (46%), Gaps = 6/229 (2%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEI---QNLIASDRDPNIVRLYGCDQDDNFVYISLERCHCSLADL 224 VA+K L +T+ +++ +++ PNI+ L G V I E D Sbjct: 652 VAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIHLEGVVTKSRPVMIITEFMENCALDS 711 Query: 225 IQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKPQNVL 404 + D F+ + QL+ ++R + AG+ +L + +HRDL +N+L Sbjct: 712 FLRLNDGQFTVI----------------QLVGMLRGIAAGMKYLSEMNYVHRDLAARNIL 755 Query: 405 ISKEGSLSAKLSDMGISKRLQEDMSSLSHHGT--GYGSSGWQAPEQLRRASQTRAMDLFS 578 ++ +L K+SD G+S+ L++D + ++ + G W APE + T A D++S Sbjct: 756 VN--SNLVCKVSDFGLSRFLEDDPADPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWS 813 Query: 579 LGCLIFYCITKGKHPFGEYYERD-INIINGHFDLFVVDHIPEAVHLISL 722 G +++ ++ G+ P+ + +D IN + + L P A+H + L Sbjct: 814 YGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLML 862
>Q8AYC9:CHK1_CHICK Serine/threonine-protein kinase Chk1 - Gallus gallus (Chicken)| Length = 476 Score = 70.1 bits (170), Expect = 2e-11 Identities = 57/210 (27%), Positives = 104/210 (49%), Gaps = 22/210 (10%) Frame = +3 Query: 30 EGSYDGREVAVKRLLRSHTDIAQKEIQNLIASD---------------RDPNIVRLYGCD 164 EG+Y ++AV R R+ +A K + A+D N+V+ YG Sbjct: 17 EGAYGEVQLAVNR--RTEEAVAVKIVDMKRAADCPENIKKEICINKMLNHENVVKFYGHR 74 Query: 165 QDDNFVYISLERCHCSLADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAG 344 ++ Y+ LE +CS +L ++I+ ++ G+P P+ + + ++AG Sbjct: 75 REGATQYLFLE--YCSGGELF-----------DRIEPDI----GMPEPEAQRFFQQLIAG 117 Query: 345 IVHLHSLGIIHRDLKPQNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTG------Y 506 +V+LHS+GI HRDLKP+N+L+ + +L K+SD G++ + H+G Sbjct: 118 VVYLHSMGITHRDLKPENLLLDERDNL--KISDFGLA-------TVFKHNGRERLLNKMC 168 Query: 507 GSSGWQAPEQLRRAS-QTRAMDLFSLGCLI 593 G+ + APE LRR + +D+++ G ++ Sbjct: 169 GTLPYVAPELLRRPEFRAEPVDVWACGVVL 198
>O59790:ARK1_SCHPO Serine/threonine-protein kinase ark1 - Schizosaccharomyces pombe| (Fission yeast) Length = 355 Score = 70.1 bits (170), Expect = 2e-11 Identities = 71/273 (26%), Positives = 121/273 (44%), Gaps = 14/273 (5%) Frame = +3 Query: 54 VAVKRLLRSHTDIAQKEIQNLIASD-------RDPNIVRLYGCDQDDNFVYISLERCHCS 212 VA+K L +S ++ Q +I+ + + R NI+RLYG D+ +Y+ LE Sbjct: 115 VALKTLHKS--ELVQSKIEKQVRREIEIQSNLRHKNILRLYGHFHDEKRIYLILE----- 167 Query: 213 LADLIQQHTDPSFSDVEKIDVELWTQDGLPSPQLLKLMRDVVAGIVHLHSLGIIHRDLKP 392 F+ ++ L K + + + +LH +IHRD+KP Sbjct: 168 ------------FAGRGELYQHLRRAKRFSEEVASKYIFQMANALSYLHKKHVIHRDIKP 215 Query: 393 QNVLISKEGSLSAKLSDMGISKRLQEDMSSLSHHGTGYGSSGWQAPEQLRRASQTRAMDL 572 +N+L+ +G + KLSD G S + + T G+ + PE + T +DL Sbjct: 216 ENILLGIDGEI--KLSDFGWSVHAPSNRRT-----TLCGTLDYLPPEMVEGKEHTEKVDL 268 Query: 573 FSLGCLIFYCITKGKHPFGEY------YERDINIINGHFDLFVVDHI-PEAVHLISLLLQ 731 +SLG L + + G PF + Y+R + DL + + P+A LIS LLQ Sbjct: 269 WSLGVLTYEFLV-GAPPFEDMSGHSATYKRIAKV-----DLKIPSFVPPDARDLISRLLQ 322 Query: 732 PKPDERPTAMYAINHPLFWSPELRLLFLRDTSD 830 P++R + + HP W + + + R +S+ Sbjct: 323 HNPEKRMSLEQVMRHP--WIVKYKDSWTRKSSE 353 Database: uniprot_sprot.fasta.out Posted date: Jul 19, 2007 5:58 PM Number of letters in database: 100,686,439 Number of sequences in database: 274,295 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 274295 Number of Hits to DB: 235,234,461 Number of extensions: 5240746 Number of successful extensions: 18076 Number of sequences better than 10.0: 2547 Number of HSP's gapped: 16783 Number of HSP's successfully gapped: 2622 Length of query: 441 Length of database: 100,686,439 Length adjustment: 116 Effective length of query: 325 Effective length of database: 68,868,219 Effective search space: 22382171175 Effective search space used: 22382171175 Neighboring words threshold: 12 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
