ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | FLbaf90j07 |
|---|---|
| Clone Library Name | barley_pub |
>Q9USP8:IDH2_SCHPO Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial precursor -| Schizosaccharomyces pombe (Fission yeast) Length = 378 Score = 490 bits (1262), Expect = e-138 Identities = 253/374 (67%), Positives = 303/374 (81%), Gaps = 4/374 (1%) Frame = +2 Query: 77 MRTA-RLQHISRPAFQIVQSRFASSQVAA--FQGQKGSDGKYTVSLIEGDGIGPEIAQSV 247 +RTA L+ SR A RF+S++ AA ++G K ++G YTV++I GDGIGPEIAQSV Sbjct: 7 LRTAGSLRTFSRSA--CYSFRFSSTKAAAGTYEGVKNANGNYTVTMIAGDGIGPEIAQSV 64 Query: 248 KDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYVALKGPLATPIGKGHVSL 427 + I+ AA VPI+WE + V P L +G T IPD++ S+++N VALKGPLATPIGKGHVS+ Sbjct: 65 ERIFKAAKVPIEWERVKVYPILK-NGTTTIPDDAKESVRKNKVALKGPLATPIGKGHVSM 123 Query: 428 NLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKL 607 NLTLRRTF LFANVRPC SI GYKTPYDNV+TVLIRENTEGEYSGIEH V+ GVVQSIKL Sbjct: 124 NLTLRRTFGLFANVRPCVSITGYKTPYDNVNTVLIRENTEGEYSGIEHEVIPGVVQSIKL 183 Query: 608 ITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAE 787 ITR ASERV+R+AFQYA+ GK + VVHKATIM+M+DGLFL +E+A EYP+IE E Sbjct: 184 ITRAASERVIRYAFQYARQTGKNNITVVHKATIMRMADGLFLECAKELAPEYPDIELREE 243 Query: 788 LLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAV 967 +LDNACLK+VTDP PYN+ V+VMPNLYGDI+SDMCAGLIGGLGLTPSGNIG++ SIFEAV Sbjct: 244 ILDNACLKIVTDPVPYNNTVMVMPNLYGDIVSDMCAGLIGGLGLTPSGNIGNQASIFEAV 303 Query: 968 HGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIFKTLAEGKTI-TGDLGGK 1144 HG+APDIAGKGLANPTALLLSS+MML+HM L ++A +I++AIF TLA T DLGGK Sbjct: 304 HGTAPDIAGKGLANPTALLLSSVMMLKHMNLNDYAKRIESAIFDTLANNPDARTKDLGGK 363 Query: 1145 SKTHEYAAAVIKNL 1186 S +Y A+I L Sbjct: 364 SNNVQYTDAIISKL 377
>P28241:IDH2_YEAST Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial precursor -| Saccharomyces cerevisiae (Baker's yeast) Length = 369 Score = 450 bits (1157), Expect = e-126 Identities = 228/338 (67%), Positives = 278/338 (82%), Gaps = 2/338 (0%) Frame = +2 Query: 179 SDGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIAS 358 S GKYTVS IEGDGIGPEI++SVK I+SAANVPI+WES DV+P + +G T IPD ++ S Sbjct: 33 STGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSP-IFVNGLTTIPDPAVQS 91 Query: 359 IKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRE 538 I +N VALKGPLATPIGKGH SLNLTLR+TF LFANVRP KSI+G+KT Y+NVD VLIRE Sbjct: 92 ITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRE 151 Query: 539 NTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMS 718 NTEGEYSGIEH+V GVVQSIKLITR+ASERV+R+AF+YA+ IG+P+V VVHK+TI +++ Sbjct: 152 NTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLA 211 Query: 719 DGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 DGLF+N+ +E++KEYP++ + EL+DN+ LKVVT+P+ Y D V V PNLYGDILSD+ +G Sbjct: 212 DGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSG 271 Query: 899 L-IGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHAN 1075 L G LGLTPS NIG + SIFEAVHGSAPDIAG+ ANPTALLLSS+MML HMGL HA+ Sbjct: 272 LSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNHMGLTNHAD 331 Query: 1076 KIQAAIFKTLAEG-KTITGDLGGKSKTHEYAAAVIKNL 1186 +IQ A+ T+A G + TGDL G + T + AVIK L Sbjct: 332 QIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL 369
>O94230:IDH2_KLULA Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial precursor -| Kluyveromyces lactis (Yeast) (Candida sphaerica) Length = 368 Score = 438 bits (1126), Expect = e-122 Identities = 222/336 (66%), Positives = 272/336 (80%), Gaps = 2/336 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 GKYTVS IEGDG+GPEI++SVK I+SAA VPI+WES DV+P + +G T IPD ++ASI Sbjct: 34 GKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSP-IFVNGLTTIPDPAVASIN 92 Query: 365 RNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENT 544 +N +ALKGPLATPIGKGH SLNLTLR+TF LFANVRP KSI+GYKT Y+NV+ VLIRENT Sbjct: 93 KNLIALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLIRENT 152 Query: 545 EGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDG 724 EGEYSGIEHVV GVVQSIKLIT++ASERV+R+AF+YA+ + + KV VVHK+TI +++DG Sbjct: 153 EGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTIQRLADG 212 Query: 725 LFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGL- 901 LF+++ ++++ EYP+IE ELLDN LK V P Y+D V+V PNLYGDILSD+ +GL Sbjct: 213 LFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDILSDLNSGLS 272 Query: 902 IGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKI 1081 G LGLTPS NIG SIFEAVHGSAPDIAG+ ANPTALLLSS+MML HMGL EHA+KI Sbjct: 273 AGSLGLTPSANIGHTVSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNHMGLTEHADKI 332 Query: 1082 QAAIFKTLA-EGKTITGDLGGKSKTHEYAAAVIKNL 1186 + A+ T+A + K TGDLGG + T + AVI+ L Sbjct: 333 EKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
>Q9VWH4:IDH3A_DROME Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial| precursor - Drosophila melanogaster (Fruit fly) Length = 377 Score = 428 bits (1101), Expect = e-119 Identities = 211/336 (62%), Positives = 267/336 (79%) Frame = +2 Query: 179 SDGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIAS 358 S G V+LI GDGIGPEI+ +V+ I++AANVPI+WE++DVTP DGK IP +I S Sbjct: 44 SSGTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRGPDGKFGIPQAAIDS 103 Query: 359 IKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRE 538 + N + LKGPL TP+GKGH SLNL LR+ FNL+ANVRPC+S++GYKT YD+VD V IRE Sbjct: 104 VNTNKIGLKGPLMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRE 163 Query: 539 NTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMS 718 NTEGEYSGIEH +VDGVVQSIKLIT EAS+RV +AFQYA++ + KV VVHKA IM+MS Sbjct: 164 NTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMS 223 Query: 719 DGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 DGLFL R++A+++P I+F+ + LD CL +V +P Y+ VLVMPNLYGDILSDMCAG Sbjct: 224 DGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYD--VLVMPNLYGDILSDMCAG 281 Query: 899 LIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANK 1078 L+GGLGLTPSGN+G ++FE+VHG+APDIAGK LANPTALLLS++MML+HM L +A+K Sbjct: 282 LVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADK 341 Query: 1079 IQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 I+ A F+T+ EGK +TGDLGG++K E+ + L Sbjct: 342 IERAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL 377
>Q9D6R2:IDH3A_MOUSE Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor| - Mus musculus (Mouse) Length = 366 Score = 404 bits (1039), Expect = e-112 Identities = 203/335 (60%), Positives = 259/335 (77%), Gaps = 1/335 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 G TV+LI GDGIGPEI+ SV I+ AA PI+WE +VT GK +IP E+ S+ Sbjct: 30 GVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPPEAKESMD 89 Query: 365 RNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENT 544 +N + LKGPL TPI GH S+NL LR+TF+L+ANVRPC SI+GYKTPY +V+ V IRENT Sbjct: 90 KNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENT 149 Query: 545 EGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDG 724 EGEYSGIEHV+VDGVVQSIKLIT EAS+R+ FAF+YA++ + V VHKA IM+MSDG Sbjct: 150 EGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDG 209 Query: 725 LFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLI 904 LFL RE+A+ +I+F+ LD CL +V DP+ ++ VLVMPNLYGDILSD+CAGLI Sbjct: 210 LFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFD--VLVMPNLYGDILSDLCAGLI 267 Query: 905 GGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKI 1081 GGLG+TPSGNIG + +IFE+VHG+APDIAGK +ANPTALLLS++MML+HMGLF+HA KI Sbjct: 268 GGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKI 327 Query: 1082 QAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 +AA F T+ +GK++T DLGG +K ++ + + + Sbjct: 328 EAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRV 362
>Q99NA5:IDH3A_RAT Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor| - Rattus norvegicus (Rat) Length = 366 Score = 400 bits (1027), Expect = e-111 Identities = 202/335 (60%), Positives = 257/335 (76%), Gaps = 1/335 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 G TV+LI GDGIGPEI+ SV I+ AA PI+WE +VT GK +IP E+ S+ Sbjct: 30 GVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPPEAKESMD 89 Query: 365 RNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENT 544 +N + LKGPL TPI GH S+NL LR+TF+L+ANVRPC SI+GYKTPY +V+ V IRENT Sbjct: 90 KNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENT 149 Query: 545 EGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDG 724 EGEYSGIEHV+VDGVVQSIKLIT AS+R+ FAF+YA++ + V VHKA IM+MSDG Sbjct: 150 EGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDG 209 Query: 725 LFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLI 904 LFL RE+A+ +I+F+ LD CL +V DP+ ++ VLVMPNLYGDILSD+CAGLI Sbjct: 210 LFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFD--VLVMPNLYGDILSDLCAGLI 267 Query: 905 GGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKI 1081 GGLG+T SGNIG + +IFE+VHG+APDIAGK +ANPTALLLS++MML+HMGLF+HA KI Sbjct: 268 GGLGVTQSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKI 327 Query: 1082 QAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 +AA F T+ +GK++T DLGG SK ++ + + + Sbjct: 328 EAACFATIKDGKSLTKDLGGNSKCSDFTEEICRRV 362
>Q5R678:IDH3A_PONPY Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor| - Pongo pygmaeus (Orangutan) Length = 366 Score = 400 bits (1027), Expect = e-111 Identities = 200/335 (59%), Positives = 258/335 (77%), Gaps = 1/335 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 G TV+LI GDGIGPEI+ +V I+ AA PI+WE +VT GK +IP E+ S+ Sbjct: 30 GVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMD 89 Query: 365 RNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENT 544 +N + LKGPL TPI GH S+NL LR+TF+L+ANVRPC SI+GYKTPY +V+ V IRENT Sbjct: 90 KNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENT 149 Query: 545 EGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDG 724 EGEYSGIEHV+VDGVVQSIKLIT AS+R+ FAF+YA++ + V VHKA IM+MSDG Sbjct: 150 EGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDG 209 Query: 725 LFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLI 904 LFL RE+A+ +I+F+ LD CL +V DP+ ++ VLVMPNLYGDILSD+CAGLI Sbjct: 210 LFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFD--VLVMPNLYGDILSDLCAGLI 267 Query: 905 GGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKI 1081 GGLG+TPSGNIG + +IFE+VHG+APDIAGK +ANPTALLLS++MML+HMGLF+HA +I Sbjct: 268 GGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARI 327 Query: 1082 QAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 +AA F T+ +GK++T DLGG +K ++ + + + Sbjct: 328 EAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRV 362
>P50213:IDH3A_HUMAN Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor| - Homo sapiens (Human) Length = 366 Score = 400 bits (1027), Expect = e-111 Identities = 200/335 (59%), Positives = 258/335 (77%), Gaps = 1/335 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 G TV+LI GDGIGPEI+ +V I+ AA PI+WE +VT GK +IP E+ S+ Sbjct: 30 GVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMD 89 Query: 365 RNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENT 544 +N + LKGPL TPI GH S+NL LR+TF+L+ANVRPC SI+GYKTPY +V+ V IRENT Sbjct: 90 KNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENT 149 Query: 545 EGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDG 724 EGEYSGIEHV+VDGVVQSIKLIT AS+R+ FAF+YA++ + V VHKA IM+MSDG Sbjct: 150 EGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDG 209 Query: 725 LFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLI 904 LFL RE+A+ +I+F+ LD CL +V DP+ ++ VLVMPNLYGDILSD+CAGLI Sbjct: 210 LFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFD--VLVMPNLYGDILSDLCAGLI 267 Query: 905 GGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKI 1081 GGLG+TPSGNIG + +IFE+VHG+APDIAGK +ANPTALLLS++MML+HMGLF+HA +I Sbjct: 268 GGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARI 327 Query: 1082 QAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 +AA F T+ +GK++T DLGG +K ++ + + + Sbjct: 328 EAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRV 362
>P41563:IDH3A_BOVIN Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor| - Bos taurus (Bovine) Length = 366 Score = 400 bits (1027), Expect = e-111 Identities = 205/354 (57%), Positives = 263/354 (74%), Gaps = 6/354 (1%) Frame = +2 Query: 143 SSQVAAFQGQKG-----SDGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTP 307 S + AF QK + G TV+LI GDGIGPEI+ +V I+ AA PI+WE +V Sbjct: 11 SRLLGAFHNQKQVTRGFAGGVKTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVAA 70 Query: 308 SLNADGKTVIPDESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSI 487 GK +IP E+ S+ +N + LKGPL TPI GH S+NL LR+TF+L+ANVRPC SI Sbjct: 71 IQGPGGKWMIPPEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSI 130 Query: 488 QGYKTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDI 667 +GYKTPY +V+ V IRENTEGEYSGIEHV+VDGVVQSIKLIT AS+R+ FAF+YA++ Sbjct: 131 EGYKTPYHDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEAASKRIAEFAFEYARNN 190 Query: 668 GKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKV 847 + V VHKA IM+MSDGLFL RE+A+ +I+F+ LD CL +V DP+ ++ V Sbjct: 191 HRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFD--V 248 Query: 848 LVMPNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALL 1024 LVMPNLYGDILSD+CAGLIGGLG+TPSGNIG + +IFE+VHG+APDIAGK +ANPTALL Sbjct: 249 LVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALL 308 Query: 1025 LSSIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 LS++MML+HMGLF+HA KI+ A F T+ +GK++T DLGG SK ++ + + + Sbjct: 309 LSAVMMLRHMGLFDHAAKIETACFATIKDGKSLTKDLGGNSKCSDFTEEICRRV 362
>Q28480:IDH3A_MACFA Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor| - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) Length = 347 Score = 398 bits (1023), Expect = e-110 Identities = 199/335 (59%), Positives = 257/335 (76%), Gaps = 1/335 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 G TV+LI GDGIGPEI+ +V I+ AA PI+WE +VT GK +IP E+ S+ Sbjct: 11 GVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMD 70 Query: 365 RNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENT 544 +N + LKGPL TPI GH S+NL LR+TF+L+ANVRPC SI+GYKTPY +V+ V IRENT Sbjct: 71 KNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENT 130 Query: 545 EGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDG 724 EGEYSGIEHV+VDGVVQSIKLIT S+R+ FAF+YA++ + V VHKA IM+MSDG Sbjct: 131 EGEYSGIEHVIVDGVVQSIKLITEGGSKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDG 190 Query: 725 LFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLI 904 LFL RE+A+ +I+F+ LD CL +V DP+ ++ VLVMPNLYGDILSD+CAGLI Sbjct: 191 LFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFD--VLVMPNLYGDILSDLCAGLI 248 Query: 905 GGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKI 1081 GGLG+TPSGNIG + +IFE+VHG+APDIAGK +ANPTALLLS++MML+HMGLF+HA +I Sbjct: 249 GGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARI 308 Query: 1082 QAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 +AA F T+ +GK++T DLGG +K ++ + + + Sbjct: 309 EAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRV 343
>Q93714:IDH3A_CAEEL Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial| precursor - Caenorhabditis elegans Length = 358 Score = 391 bits (1004), Expect = e-108 Identities = 196/326 (60%), Positives = 244/326 (74%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 V+LI GDGIGPEI+ SV+ I+ AA+ PI W+ +DVTP DG IP I + N V Sbjct: 27 VTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRDGVFRIPSRCIELMHANKV 86 Query: 377 ALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENTEGEY 556 LKGPL TPIGKGH SLNL +R+ F+L+ANVRPC+S++G+KT YDNVD V IRENTEGEY Sbjct: 87 GLKGPLETPIGKGHRSLNLAVRKEFSLYANVRPCRSLEGHKTLYDNVDVVTIRENTEGEY 146 Query: 557 SGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLN 736 SGIEH +V GVVQSIKLIT AS V FAF+YA+ G+ V VHKA IM+ SDGLFL+ Sbjct: 147 SGIEHEIVPGVVQSIKLITETASRNVASFAFEYARQNGRKVVTAVHKANIMRQSDGLFLS 206 Query: 737 LGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLG 916 + RE A YP+I+F LD CL +V DP+ Y+ VLVMPNLYGDILSD+CAGL+GGLG Sbjct: 207 ICREQAALYPDIKFKEAYLDTVCLNMVQDPSQYD--VLVMPNLYGDILSDLCAGLVGGLG 264 Query: 917 LTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIF 1096 +TPSGNIG ++FE+VHG+APDIAG+ ANPTALLLS++MML++M L +HA +I+ A+F Sbjct: 265 VTPSGNIGKGAAVFESVHGTAPDIAGQDKANPTALLLSAVMMLRYMNLPQHAARIEKAVF 324 Query: 1097 KTLAEGKTITGDLGGKSKTHEYAAAV 1174 +A+G+ TGDLGG + A V Sbjct: 325 DAIADGRAKTGDLGGTGTCSSFTADV 350
>Q945K7:IDH5_ARATH Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial| precursor - Arabidopsis thaliana (Mouse-ear cress) Length = 374 Score = 385 bits (990), Expect = e-106 Identities = 199/350 (56%), Positives = 257/350 (73%), Gaps = 1/350 (0%) Frame = +2 Query: 140 ASSQVAAFQGQKGSDGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNA 319 ASS AF S T +L GDGIGPEIA+SVK +++ A VPI+WE V ++ Sbjct: 30 ASSVARAFCS---STTPITATLFPGDGIGPEIAESVKKVFTTAGVPIEWEEHYVGTEIDP 86 Query: 320 DGKTVIPDESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYK 499 ++ + ES+ S++RN V LKGP+ATPIGKGH SLNLTLR+ NL+ANVRPC S+ GYK Sbjct: 87 RTQSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYK 146 Query: 500 TPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPK 679 T YD+VD + IRENTEGEYSG+EH VV GVV+S+K+ITR+AS RV +AF YA+ G+ + Sbjct: 147 TRYDDVDLITIRENTEGEYSGLEHQVVRGVVESLKIITRQASLRVAEYAFLYAKTHGRER 206 Query: 680 VRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMP 859 V +HKA IM+ +DGLFL RE+A++YP I ++ ++DN C+ +V +P ++ VLVMP Sbjct: 207 VSAIHKANIMQKTDGLFLKCCREVAEKYPEITYEEVVIDNCCMMLVKNPALFD--VLVMP 264 Query: 860 NLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSSI 1036 NLYGDI+SD+CAGL+GGLGLTPS NIG D ++ EAVHGSAPDIAGK LANPTALLLS + Sbjct: 265 NLYGDIISDLCAGLVGGLGLTPSCNIGEDGVALAEAVHGSAPDIAGKNLANPTALLLSGV 324 Query: 1037 MMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 MML+H+ E A +I +AI T+AEGK T DLGG S T E+ A+ +L Sbjct: 325 MMLRHLKFNEQAEQIHSAIINTIAEGKYRTADLGGSSTTTEFTKAICDHL 374
>Q8LG77:IDH6_ARATH Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial| precursor - Arabidopsis thaliana (Mouse-ear cress) Length = 374 Score = 369 bits (946), Expect = e-101 Identities = 186/330 (56%), Positives = 246/330 (74%), Gaps = 1/330 (0%) Frame = +2 Query: 200 SLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYVA 379 +L GDGIGPEIA+SVK +++AA+V I W+ V ++ + + +++ S+ +N V Sbjct: 47 TLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVG 106 Query: 380 LKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENTEGEYS 559 LKGP+ATPIGKGH SLNLTLR+ NL+ANVRPC S+ GYKT YD+VD + IRENTEGEYS Sbjct: 107 LKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYS 166 Query: 560 GIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNL 739 G+EH VV GVV+S+K+ITR+AS RV +AF YA+ G+ KV +HKA IM+ +DGLFL Sbjct: 167 GLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQC 226 Query: 740 GREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGL 919 E+A +YP I ++ ++DN C+ +V +P ++ VLVMPNLYGDI+SD+CAGL+GGLGL Sbjct: 227 CDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFD--VLVMPNLYGDIISDLCAGLVGGLGL 284 Query: 920 TPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIF 1096 TPS NIG D ++ EAVHGSAPDIAG LANPTALLLS +MML+H+ L + A +I +AI Sbjct: 285 TPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAII 344 Query: 1097 KTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 T+AEGK T DLGG S T ++ A+ +L Sbjct: 345 NTIAEGKYRTADLGGSSTTTDFTKAICDHL 374
>P29696:LEU3_SOLTU 3-isopropylmalate dehydrogenase, chloroplast precursor - Solanum| tuberosum (Potato) Length = 357 Score = 363 bits (933), Expect = e-100 Identities = 182/307 (59%), Positives = 238/307 (77%), Gaps = 1/307 (0%) Frame = +2 Query: 200 SLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYVA 379 +L GDGIGPEIA+SV+ I+ A VPI+WE V ++ + + ES+ S++RN V Sbjct: 40 TLFPGDGIGPEIAESVRQIFKVAEVPIEWEEHYVGTEVDPRTNSFLTWESLESVRRNKVG 99 Query: 380 LKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENTEGEYS 559 LKGP+ATPIGKGH SLNLTLR+ NL+ANVRPC S+ GYKT YD+V+ + IRENTEGEYS Sbjct: 100 LKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVNLITIRENTEGEYS 159 Query: 560 GIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNL 739 G+EH VV GVV+S+K+ITR+AS RV +AF YA+ G+ +V +HKA IM+ +DGLFL Sbjct: 160 GLEHQVVRGVVESLKIITRQASLRVAEYAFHYAKTHGRERVSAIHKANIMQKTDGLFLKC 219 Query: 740 GREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGL 919 RE+A++YP I+++ ++DN C+ +V +P ++ VLVMPNLYGDI+SD+CAGLIGGLGL Sbjct: 220 CREVAEKYPEIKYEEVVIDNCCMMLVKNPALFD--VLVMPNLYGDIISDLCAGLIGGLGL 277 Query: 920 TPSGNIGD-ECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIF 1096 TPS NIG+ ++ EAVHGSAPDIAGK LANPTALLLSS+ ML+H+ L + A++IQ AI Sbjct: 278 TPSCNIGEGGIALAEAVHGSAPDIAGKNLANPTALLLSSVSMLRHLELHDKADRIQDAIL 337 Query: 1097 KTLAEGK 1117 KT+A GK Sbjct: 338 KTIAGGK 344
>O13302:IDH1_AJECA Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial precursor -| Ajellomyces capsulata (Histoplasma capsulatum) Length = 388 Score = 325 bits (832), Expect = 4e-88 Identities = 180/382 (47%), Positives = 253/382 (66%), Gaps = 5/382 (1%) Frame = +2 Query: 56 AAPARQCMRTARLQH-ISRPAFQIVQSRFASSQVAAFQGQKGSDGKYTVSLIEGDGIGPE 232 A PA+ R A + S P I FA+ Q F+ K GKYTV+LI GDGIG E Sbjct: 7 AQPAQSLFRAATNTYSTSLPRSAIAARSFATVQSDIFKPTKYG-GKYTVTLIPGDGIGTE 65 Query: 233 IAQSVKDIYSAANVPIKWESIDVTPSLNADGKTV--IPDESIASIKRNYVALKGPLATPI 406 +A+SVK I+ A NVPI+WE +DV+ L+A K + ESIAS+KRN + LKG L TP+ Sbjct: 66 VAESVKTIFKADNVPIEWEQVDVS-GLDAGNKHSEDLFKESIASLKRNKLGLKGILHTPV 124 Query: 407 GK-GHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENTEGEYSGIEHVVVD 583 + GH S N+ LR+ +++A++ K+I GYKT +DNVD +IRENTEGEYSG+EH V Sbjct: 125 ERSGHQSFNVALRQELDIYASIVLIKNIPGYKTRHDNVDLCIIRENTEGEYSGLEHQSVS 184 Query: 584 GVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEY 763 GVV+S+K+ITR SER+ +FAF +A + KV +HKA IMK++DGLF + ++A+ Y Sbjct: 185 GVVESLKIITRAKSERIAKFAFSFALANNRKKVTCIHKANIMKLADGLFRSTFHKVAESY 244 Query: 764 PNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD 943 P +E + ++DNA ++ V P ++ V+VMPNLYG ILS++ A L+GG G+ P N+G Sbjct: 245 PTLETNDMIVDNASMQAVARPQQFD--VMVMPNLYGGILSNVGAALVGGPGIVPGCNMGR 302 Query: 944 ECSIFE-AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIFKTLAEGKT 1120 + ++FE DI GK ANPTAL+LS M+L+H+GL EHAN+I A++ + EG T Sbjct: 303 DVAVFEPGCRHVGLDIKGKDQANPTALILSGSMLLRHLGLDEHANRISKAVYDVIGEGVT 362 Query: 1121 ITGDLGGKSKTHEYAAAVIKNL 1186 T D+GG++ THE+ AV+ + Sbjct: 363 RTRDMGGQASTHEFTRAVLDKM 384
>O94229:IDH1_KLULA Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial precursor -| Kluyveromyces lactis (Yeast) (Candida sphaerica) Length = 361 Score = 293 bits (749), Expect = 2e-78 Identities = 159/337 (47%), Positives = 220/337 (65%), Gaps = 3/337 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 G+YTV+LI GDG+G E+ SV I+ N+PI WE+ID++ N + ++ S+K Sbjct: 28 GRYTVTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISGLENTENV----QRAVESLK 83 Query: 365 RNYVALKGPLATPIGK-GHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIREN 541 RN V LKG TP + GH SLN+ LR+ ++FANV KSI G KT +N+D V+IREN Sbjct: 84 RNKVGLKGIWHTPADQTGHGSLNVALRKQLDIFANVALFKSIPGVKTRLNNIDMVIIREN 143 Query: 542 TEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSD 721 TEGEYSG+EH V GVV+S+K++TR SER+ RFAF +A + V VHKA IMK+ D Sbjct: 144 TEGEYSGLEHESVPGVVESLKIMTRAKSERIARFAFDFALKNNRKSVCAVHKANIMKLGD 203 Query: 722 GLFLNLGREI-AKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 GLF N EI A EYP ++ ++DNA ++ V P ++ VLV PNLYG IL ++ + Sbjct: 204 GLFRNTVNEIGANEYPELDVKNIIVDNASMQAVAKPHQFD--VLVTPNLYGSILGNIGSA 261 Query: 899 LIGGLGLTPSGNIGDECSIFE-AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHAN 1075 LIGG GL P N G E ++FE DI G+ +ANPTA++LSS +ML+H+GL +A+ Sbjct: 262 LIGGPGLVPGANFGREYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLRHLGLNAYAD 321 Query: 1076 KIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 +I A + ++EGK+ T D+GG + T E+ AVI+ L Sbjct: 322 RISKATYDVISEGKSTTRDIGGSASTSEFTNAVIEKL 358
>P28834:IDH1_YEAST Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial precursor -| Saccharomyces cerevisiae (Baker's yeast) Length = 360 Score = 288 bits (737), Expect = 4e-77 Identities = 152/337 (45%), Positives = 225/337 (66%), Gaps = 3/337 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 G++TV+LI GDG+G EI SV+ I+ A N+PI WE+I++ + + +G E++ S+K Sbjct: 27 GRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVY----EAVESLK 82 Query: 365 RNYVALKGPLATPIGK-GHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIREN 541 RN + LKG TP + GH SLN+ LR+ +++ANV KS++G KT ++D ++IREN Sbjct: 83 RNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIREN 142 Query: 542 TEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSD 721 TEGE+SG+EH V GVV+S+K++TR +ER+ RFAF +A+ + V VHKA IMK+ D Sbjct: 143 TEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGD 202 Query: 722 GLFLNLGREIA-KEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 GLF N+ EI KEYP+I+ + ++DNA ++ V P ++ VLV P++YG IL ++ A Sbjct: 203 GLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFD--VLVTPSMYGTILGNIGAA 260 Query: 899 LIGGLGLTPSGNIGDECSIFE-AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHAN 1075 LIGG GL N G + ++FE DI G+ +ANPTA++LSS +ML H+GL E+A Sbjct: 261 LIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYAT 320 Query: 1076 KIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 +I A+ +T+AEGK T D+GG S T ++ +I L Sbjct: 321 RISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357
>Q8LFC0:IDH1_ARATH Isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial| precursor - Arabidopsis thaliana (Mouse-ear cress) Length = 367 Score = 286 bits (732), Expect = 1e-76 Identities = 153/348 (43%), Positives = 226/348 (64%), Gaps = 6/348 (1%) Frame = +2 Query: 161 FQGQKGSDGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIP 340 + + G V+LI GDGIGP + +V+ + A + PI +E DV ++ +P Sbjct: 28 YMPRPGDGAPRAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKYDVHGEMSR-----VP 82 Query: 341 DESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVD 520 E + SI++N V LKG L TP+G G SLN+ LR+ +LFA++ C ++ G T ++NVD Sbjct: 83 PEVMESIRKNKVCLKGGLKTPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVD 142 Query: 521 TVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKA 700 V+IRENTEGEY+G+EH VV GVV+S+K+IT+ SER+ ++AF+YA + KV VHKA Sbjct: 143 IVVIRENTEGEYAGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKA 202 Query: 701 TIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDIL 880 IMK++DGLFL RE+AK+YP+I ++ ++DN C+++V P ++ V+V PNLYG+++ Sbjct: 203 NIMKLADGLFLESCREVAKKYPSITYNEIIVDNCCMQLVAKPEQFD--VMVTPNLYGNLV 260 Query: 881 SDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGK------GLANPTALLLSSIMM 1042 ++ AG+ GG G+ P GN+G + ++FE G++ GK ANP ALLLSS MM Sbjct: 261 ANTAAGIAGGTGVMPGGNVGADHAVFE--QGASAGNVGKDKIVLENKANPVALLLSSAMM 318 Query: 1043 LQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 L+H+ A++++ A+ K +AEGK T DLGG S T E AVI L Sbjct: 319 LRHLQFPSFADRLETAVKKVIAEGKCRTKDLGGTSTTQEVVDAVIAKL 366
>O13696:IDH1_SCHPO Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial precursor -| Schizosaccharomyces pombe (Fission yeast) Length = 356 Score = 286 bits (731), Expect = 2e-76 Identities = 158/347 (45%), Positives = 227/347 (65%), Gaps = 3/347 (0%) Frame = +2 Query: 155 AAFQGQKGSDGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTP-SLNADGKT 331 +AFQ K GKYTV+LI GDGIG E + +V +I+ ANVPI++E IDVT N Sbjct: 10 SAFQPLKYG-GKYTVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDVTGMEKNNKSSG 68 Query: 332 VIPDESIASIKRNYVALKGPLATPIGKG-HVSLNLTLRRTFNLFANVRPCKSIQGYKTPY 508 E+I S+KRN V LKG L TP KG H S N+ LR+ +++A++ K+I G+KT + Sbjct: 69 DALHEAIQSLKRNKVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGFKTRH 128 Query: 509 DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRV 688 DNVD +IRENTEGEYSG+EH V GVV+S+K+IT S+R+ +FAF +A G+ V Sbjct: 129 DNVDFAIIRENTEGEYSGLEHQSVPGVVESLKIITEYKSKRIAQFAFDFALQNGRKSVTC 188 Query: 689 VHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLY 868 +HKA IMK++DGLF ++A Y I ++DNA ++ V+ P ++ VLVMPNLY Sbjct: 189 IHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFD--VLVMPNLY 246 Query: 869 GDILSDMCAGLIGGLGLTPSGNIGDECSIFE-AVHGSAPDIAGKGLANPTALLLSSIMML 1045 G ILS++ + L+GG G+ P N G + ++FE I G+G ANPTA +LS+ +ML Sbjct: 247 GSILSNIGSALVGGPGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLML 306 Query: 1046 QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 +H+GL ++A+ I AA + + EGKT+T DLGG + T ++ A+++ + Sbjct: 307 RHLGLKDYADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILERM 353
>P33197:IDH_THET8 Isocitrate dehydrogenase [NADP] - Thermus thermophilus (strain HB8 /| ATCC 27634 / DSM 579) Length = 496 Score = 285 bits (730), Expect = 2e-76 Identities = 152/341 (44%), Positives = 224/341 (65%), Gaps = 6/341 (1%) Frame = +2 Query: 182 DGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADG-KTVIPDESIAS 358 DG+ +++I GDGIGPE ++ + AA P+ +E + S+ G + +P E+I S Sbjct: 17 DGRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIES 76 Query: 359 IKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDN--VDTVLI 532 I++ V LKGPL TP+G G S N+TLR+ F +ANVRP + TPY +D V++ Sbjct: 77 IRKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVV 136 Query: 533 RENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMK 712 REN E Y+GIEH+ V Q++KLI+ + SE+++RFAF+ A+ G+ KV K+ IMK Sbjct: 137 RENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMK 196 Query: 713 MSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMC 892 +++G ++A+EYP+IE ++DNA ++V P + +V+V N+ GDILSD+ Sbjct: 197 LAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQF--EVIVTTNMNGDILSDLT 254 Query: 893 AGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHA 1072 +GLIGGLG PS NIG+E +IFEAVHGSAP AGK + NPTA+LLS++MML+++ F A Sbjct: 255 SGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFATA 314 Query: 1073 NKIQAAIFKTLAEGKTITGDLGG---KSKTHEYAAAVIKNL 1186 + I+ A+ TL EG+ +TGD+ G +KT EY A+I+NL Sbjct: 315 DLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNL 355
>O81796:IDH3_ARATH Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial| precursor - Arabidopsis thaliana (Mouse-ear cress) Length = 368 Score = 285 bits (728), Expect = 4e-76 Identities = 154/352 (43%), Positives = 226/352 (64%), Gaps = 5/352 (1%) Frame = +2 Query: 146 SQVAAFQGQKGSDGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADG 325 S+ + + G TV+LI GDGIGP + +V+ + A + P+ +E +V ++ Sbjct: 24 SRSITYMPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVLGNMRK-- 81 Query: 326 KTVIPDESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTP 505 +P+E I S+KRN V LKG LATP+G G SLN+ LR+ ++FA++ C ++ G T Sbjct: 82 ---VPEEVIESVKRNKVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGLVTR 138 Query: 506 YDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVR 685 ++NVD V+IRENTEGEYSG+EH VV GVV+S+K+IT+ SER+ R+AF+YA + KV Sbjct: 139 HENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNNRKKVT 198 Query: 686 VVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNL 865 VHKA IMK++DGLFL RE+AK Y I ++ ++DN C+++V P ++ V+V PNL Sbjct: 199 AVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFD--VMVTPNL 256 Query: 866 YGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGL-----ANPTALLLS 1030 YG+++++ AG+ GG G+ P GN+G E +IFE SA ++ + ANP ALLLS Sbjct: 257 YGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQ-GASAGNVGNDKMVEQKKANPVALLLS 315 Query: 1031 SIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 S MML+H+ A++++ A+ + + EGK T DLGG T E AVI L Sbjct: 316 SAMMLRHLRFPTFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAAL 367
>P93032:IDH2_ARATH Isocitrate dehydrogenase [NAD] regulatory subunit 2, mitochondrial| precursor - Arabidopsis thaliana (Mouse-ear cress) Length = 367 Score = 282 bits (721), Expect = 3e-75 Identities = 150/342 (43%), Positives = 226/342 (66%), Gaps = 7/342 (2%) Frame = +2 Query: 182 DGK-YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIAS 358 DGK V+LI GDG+GP + +V+ + A + P+ +E +V + + +P+ + S Sbjct: 34 DGKPRPVTLIPGDGVGPLVTNAVQQVMEAMHAPVYFEPFEVHGDMKS-----LPEGLLES 88 Query: 359 IKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRE 538 IK+N V LKG L TP+G G SLN+ LR+ +LFA++ C ++ G + ++NVD V+IRE Sbjct: 89 IKKNKVCLKGGLKTPVGGGVSSLNVNLRKELDLFASLVNCFNLPGLASRHENVDIVVIRE 148 Query: 539 NTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMS 718 NTEGEY+G+EH VV GVV+S+K+IT+ SER+ ++AF+YA + KV VHKA IMK++ Sbjct: 149 NTEGEYAGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLA 208 Query: 719 DGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 DGLFL +E+AK+YP+I ++ ++DN C+++V P ++ V+V PNLYG+++++ AG Sbjct: 209 DGLFLESCQEVAKKYPSIAYNEIIVDNCCMQLVARPEQFD--VMVTPNLYGNLVANTAAG 266 Query: 899 LIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGL------ANPTALLLSSIMMLQHMGL 1060 + GG G+ P GN+G E ++FE G++ GK ANP ALLLSS MML+H+ Sbjct: 267 IAGGTGVMPGGNVGAEYAVFE--QGASAGNVGKDTTEEQKNANPVALLLSSAMMLRHLQF 324 Query: 1061 FEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 A++++ A+ + +AEG T DLGG S T E AVI NL Sbjct: 325 PSFADRLETAVKRVIAEGNCRTEDLGGNSTTQEVVDAVIANL 366
>O77784:IDH3B_BOVIN Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor| - Bos taurus (Bovine) Length = 385 Score = 276 bits (707), Expect = 1e-73 Identities = 145/339 (42%), Positives = 227/339 (66%), Gaps = 4/339 (1%) Frame = +2 Query: 182 DGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASI 361 +G + V+++ GDG+GPE+ +VK+++ AA+VP++++ ++ N + + ++ ++S+ Sbjct: 46 EGAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKL-EQVLSSM 104 Query: 362 KRNYVALKGPLATPIG-KGHV-SLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIR 535 K N VA+ G + TP+ KG + S ++ LRR +LFANV KS+ GYKT ++N+D V+IR Sbjct: 105 KENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIR 164 Query: 536 ENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKM 715 E TEGEYS +EH GV++ +K++TR S+R+ +FAF YA G+ KV VHKA IMK+ Sbjct: 165 EQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYATKKGRGKVTAVHKANIMKL 224 Query: 716 SDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCA 895 DGLFL E+A+ YP I+F+ ++DN C+++V + PY VLVMPNLYG+I+ ++ A Sbjct: 225 GDGLFLQCCEEVAELYPKIKFEKMIIDNCCMQLVQN--PYQFDVLVMPNLYGNIIDNLAA 282 Query: 896 GLIGGLGLTPSGNIGDECSIFE--AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEH 1069 GL+GG G+ P + E ++FE A H A + G+ +ANPTA+LLS+ ML+H+ L H Sbjct: 283 GLVGGAGVVPGESYSAEYAVFETGARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEHH 341 Query: 1070 ANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 +N I A+ K + GK T D+GG S T ++ +VI +L Sbjct: 342 SNMIAEAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>Q68FX0:IDH3B_RAT Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor| - Rattus norvegicus (Rat) Length = 385 Score = 276 bits (705), Expect = 2e-73 Identities = 151/358 (42%), Positives = 234/358 (65%), Gaps = 7/358 (1%) Frame = +2 Query: 134 RFASSQVAAFQGQKGS---DGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVT 304 R A+S AA Q Q +G + V+++ GDG+GPE+ +VK+++ AA VP++++ ++ Sbjct: 27 RTAASAQAASQSQAQDVRVEGAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHHLS 86 Query: 305 PSLNADGKTVIPDESIASIKRNYVALKGPLATPIG-KGHV-SLNLTLRRTFNLFANVRPC 478 N + + ++ ++S+K N VA+ G + TP+ KG + S ++ LRR +LFANV Sbjct: 87 EVQNMASEEKL-EQVLSSMKENKVAIIGKIYTPMEYKGELASYDMQLRRKLDLFANVVHV 145 Query: 479 KSIQGYKTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYA 658 KS+ GYKT ++N+D V+IRE TEGEYS +EH GV++ +K++TR S+R+ +FAF YA Sbjct: 146 KSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYA 205 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 G+ KV VHKA IMK+ DGLFL E+A+ YP I+F+ ++DN C+++V + PY Sbjct: 206 TKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQN--PYQ 263 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFE--AVHGSAPDIAGKGLANP 1012 VLVMPNLYG+I+ ++ AGL+GG G+ P + E ++FE A H A + G+ +ANP Sbjct: 264 FDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAV-GRNIANP 322 Query: 1013 TALLLSSIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 TA+LLS+ ML+H+ L H++ I A+ K + GK T D+GG S T ++ +VI +L Sbjct: 323 TAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>P41565:IDH3G_RAT Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor| - Rattus norvegicus (Rat) Length = 393 Score = 273 bits (699), Expect = 1e-72 Identities = 146/337 (43%), Positives = 219/337 (64%), Gaps = 3/337 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 G++TV++I GDGIGPE+ VK ++ A VP+ +E + V S NAD + + +I +I+ Sbjct: 53 GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHV--SSNADEEDI--RNAIMAIR 108 Query: 365 RNYVALKGPLAT--PIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRE 538 RN VALKG + T + H S N LR + +L+ANV CKS+ G T + ++D +++RE Sbjct: 109 RNRVALKGNIETNHDLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRE 168 Query: 539 NTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMS 718 NTEGEYS +EH V GVV+S+K+IT+ S R+ +AF+ AQ+ G+ KV VHKA IMK+ Sbjct: 169 NTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLG 228 Query: 719 DGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 DGLFL RE+A YP I FD+ ++DN +++V+ P ++ V+VMPNLYG+I++++CAG Sbjct: 229 DGLFLQCCREVAARYPQITFDSMIVDNTTMQLVSRPQQFD--VMVMPNLYGNIVNNVCAG 286 Query: 899 LIGGLGLTPSGNIGDECSIFE-AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHAN 1075 L+GG GL N G ++FE A + IA K +ANPTA LL+S MML H+ L +A Sbjct: 287 LVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYAT 346 Query: 1076 KIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 I+ A+ ++ T D+GG+ T + +I+++ Sbjct: 347 SIRKAVLASMDNENMHTPDIGGQGTTSQAIQDIIRHI 383
>P70404:IDH3G_MOUSE Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor| - Mus musculus (Mouse) Length = 393 Score = 273 bits (698), Expect = 1e-72 Identities = 146/337 (43%), Positives = 219/337 (64%), Gaps = 3/337 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 G++TV++I GDGIGPE+ VK ++ A VP+ +E + V S NAD + + +I +I+ Sbjct: 53 GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHV--SSNADEEDI--RNAIMAIR 108 Query: 365 RNYVALKGPLATP--IGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRE 538 RN VALKG + T + H S N LR + +L+ANV CKS+ G T + ++D +++RE Sbjct: 109 RNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRE 168 Query: 539 NTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMS 718 NTEGEYS +EH V GVV+S+K+IT+ S R+ +AF+ AQ+ G+ KV VHKA IMK+ Sbjct: 169 NTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLG 228 Query: 719 DGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 DGLFL RE+A YP I FD+ ++DN +++V+ P ++ V+VMPNLYG+I++++CAG Sbjct: 229 DGLFLQCCREVAAHYPQITFDSMIVDNTTMQLVSRPQQFD--VMVMPNLYGNIVNNVCAG 286 Query: 899 LIGGLGLTPSGNIGDECSIFE-AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHAN 1075 L+GG GL N G ++FE A + IA K +ANPTA LL+S MML H+ L +A Sbjct: 287 LVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYAT 346 Query: 1076 KIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 I+ A+ ++ T D+GG+ T + +I+++ Sbjct: 347 SIRKAVLASMDNENMHTPDIGGQGTTSQAIQDIIRHI 383
>Q28479:IDH3B_MACFA Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor| - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) Length = 385 Score = 273 bits (698), Expect = 1e-72 Identities = 144/339 (42%), Positives = 225/339 (66%), Gaps = 4/339 (1%) Frame = +2 Query: 182 DGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASI 361 +G + V+++ GDG+GPE+ +VK+++ AA VP++++ ++ N + + ++ ++S+ Sbjct: 46 EGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL-EQVLSSM 104 Query: 362 KRNYVALKGPLATPIG-KGHV-SLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIR 535 K N VA+ G + TP+ KG + S ++ LRR +LFANV KS+ GY T ++N+D V+IR Sbjct: 105 KENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIR 164 Query: 536 ENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKM 715 E TEGEYS +EH GV++ +K++TR S+R+ +FAF YA G+ KV VHKA IMK+ Sbjct: 165 EQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRSKVTAVHKANIMKL 224 Query: 716 SDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCA 895 DGLFL E+A+ YP I+F+ ++DN C+++V + PY VLVMPNLYG+I+ ++ A Sbjct: 225 GDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQN--PYQFDVLVMPNLYGNIIDNLAA 282 Query: 896 GLIGGLGLTPSGNIGDECSIFE--AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEH 1069 GL+GG G+ P + E ++FE A H A + G+ +ANPTA+LLS+ ML+H+ L H Sbjct: 283 GLVGGAGVVPGESYSAEYAVFETGARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYH 341 Query: 1070 ANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 +N I A+ K + GK T D+GG S T ++ +VI +L Sbjct: 342 SNMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>P51553:IDH3G_HUMAN Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor| - Homo sapiens (Human) Length = 393 Score = 272 bits (695), Expect = 3e-72 Identities = 147/337 (43%), Positives = 218/337 (64%), Gaps = 3/337 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 G++TV++I GDGIGPE+ VK ++ A VP+ +E + V S NAD + + +I +I+ Sbjct: 53 GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHV--SSNADEEDI--RNAIMAIR 108 Query: 365 RNYVALKGPLATP--IGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRE 538 RN VALKG + T + H S N LR + +L+ANV CKS+ G T + ++D +++RE Sbjct: 109 RNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRE 168 Query: 539 NTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMS 718 NTEGEYS +EH V GVV+S+K+IT+ S R+ +AF+ AQ+ G+ KV VHKA IMK+ Sbjct: 169 NTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLG 228 Query: 719 DGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 DGLFL RE+A YP I F+ ++DN +++V+ P ++ V+VMPNLYG+I++++CAG Sbjct: 229 DGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFD--VMVMPNLYGNIVNNVCAG 286 Query: 899 LIGGLGLTPSGNIGDECSIFE-AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHAN 1075 L+GG GL N G ++FE A + IA K +ANPTA LL+S MML H+ L +A Sbjct: 287 LVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYAT 346 Query: 1076 KIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 I+ A+ ++ T D+GG+ T E VI+++ Sbjct: 347 SIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHI 383
>P41564:IDH3G_MACFA Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor| - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) Length = 355 Score = 271 bits (694), Expect = 4e-72 Identities = 146/337 (43%), Positives = 218/337 (64%), Gaps = 3/337 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 G++TV++I GDGIGPE+ VK ++ A VP+ +E + V S NAD + + +I +I+ Sbjct: 15 GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHV--SSNADEEDI--RNAIMAIR 70 Query: 365 RNYVALKGPLATP--IGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRE 538 RN VALKG + T + H S N LR + +L+ANV CKS+ G T + ++D +++RE Sbjct: 71 RNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRE 130 Query: 539 NTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMS 718 NTEGEYS +EH V GVV+S+K+IT+ S R+ +AF+ AQ+ G+ KV VHKA IMK+ Sbjct: 131 NTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLG 190 Query: 719 DGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 DGLFL RE+A YP I F+ ++DN +++V+ P ++ V+VMPNLYG+I++++CAG Sbjct: 191 DGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFD--VMVMPNLYGNIVNNVCAG 248 Query: 899 LIGGLGLTPSGNIGDECSIFE-AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHAN 1075 L+GG GL N G ++FE A + IA K +ANPTA LL+S MML H+ L +A Sbjct: 249 LVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYAT 308 Query: 1076 KIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 I+ A+ ++ T D+GG+ T E +I+++ Sbjct: 309 SIRKAVLASMDNENMHTPDIGGQGTTSEAIQDIIRHI 345
>O43837:IDH3B_HUMAN Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor| - Homo sapiens (Human) Length = 385 Score = 271 bits (692), Expect = 6e-72 Identities = 143/339 (42%), Positives = 225/339 (66%), Gaps = 4/339 (1%) Frame = +2 Query: 182 DGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASI 361 +G + V+++ GDG+GPE+ +VK+++ AA VP++++ ++ N + + ++ ++S+ Sbjct: 46 EGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL-EQVLSSM 104 Query: 362 KRNYVALKGPLATPIG-KGHV-SLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIR 535 K N VA+ G + TP+ KG + S ++ LRR +LFANV KS+ GY T ++N+D V+IR Sbjct: 105 KENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIR 164 Query: 536 ENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKM 715 E TEGEYS +EH GV++ +K++TR S+R+ +FAF YA G+ KV VHKA IMK+ Sbjct: 165 EQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKL 224 Query: 716 SDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCA 895 DGLFL E+A+ YP I+F+ ++DN C+++V + PY VLVMPNLYG+I+ ++ A Sbjct: 225 GDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQN--PYQFDVLVMPNLYGNIIDNLAA 282 Query: 896 GLIGGLGLTPSGNIGDECSIFE--AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEH 1069 GL+GG G+ P + E ++FE A H A + G+ +ANPTA+LLS+ ML+H+ L H Sbjct: 283 GLVGGAGVVPGESYSAEYAVFETGARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYH 341 Query: 1070 ANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 ++ I A+ K + GK T D+GG S T ++ +VI +L Sbjct: 342 SSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>Q58CP0:IDH3G_BOVIN Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor| - Bos taurus (Bovine) Length = 392 Score = 270 bits (691), Expect = 8e-72 Identities = 146/337 (43%), Positives = 217/337 (64%), Gaps = 3/337 (0%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 G++TV++I GDGIGPE+ VK ++ A VP+ +E + V S AD + + +I +I+ Sbjct: 52 GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHV--SSTADEEDI--RNAIMAIR 107 Query: 365 RNYVALKGPLATP--IGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRE 538 RN VALKG + T + H S N LR + +L+ANV CKS+ G T + ++D +++RE Sbjct: 108 RNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHRDIDILIVRE 167 Query: 539 NTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMS 718 NTEGEYS +EH V GVV+S+K+IT+ S R+ +AFQ AQ+ G+ KV VHKA IMK+ Sbjct: 168 NTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFQLAQESGRKKVTAVHKANIMKLG 227 Query: 719 DGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 DGLFL RE+A YP I F+ ++DN +++V+ P ++ V+VMPNLYG+I++++CAG Sbjct: 228 DGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFD--VMVMPNLYGNIVNNVCAG 285 Query: 899 LIGGLGLTPSGNIGDECSIFE-AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHAN 1075 L+GG GL N G ++FE A + IA K +ANPTA LL+S MML H+ L +A Sbjct: 286 LVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYAT 345 Query: 1076 KIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 I+ A+ ++ T D+GG+ T E +I+++ Sbjct: 346 SIRKAVLASMDNENMHTPDIGGQGTTSEAIQDIIRHI 382
>Q5RBT4:IDH3B_PONPY Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor| - Pongo pygmaeus (Orangutan) Length = 385 Score = 267 bits (682), Expect = 9e-71 Identities = 142/339 (41%), Positives = 224/339 (66%), Gaps = 4/339 (1%) Frame = +2 Query: 182 DGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASI 361 +G + V+++ GDG+GPE+ +VK+++ AA VP++++ ++ N + + ++ ++S+ Sbjct: 46 EGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL-EQVLSSM 104 Query: 362 KRNYVALKGPLATPIG-KGHV-SLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIR 535 K N VA+ G + TP+ KG + S ++ LRR +LFANV KS+ GY T ++N+D V+IR Sbjct: 105 KENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIR 164 Query: 536 ENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKM 715 E TEGE S +EH GV++ +K++TR S+R+ +FAF YA G+ KV VHKA IMK+ Sbjct: 165 EQTEGECSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRSKVIAVHKANIMKL 224 Query: 716 SDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCA 895 DGLFL E+A+ YP I+F+ ++DN C+++V + PY VLVMPNLYG+I+ ++ A Sbjct: 225 GDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQN--PYQFDVLVMPNLYGNIIDNLAA 282 Query: 896 GLIGGLGLTPSGNIGDECSIFE--AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEH 1069 GL+GG G+ P + E ++FE A H A + G+ +ANPTA+LLS+ ML+H+ L H Sbjct: 283 GLVGGAGVVPGESYSAEYAVFETGARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYH 341 Query: 1070 ANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 ++ I A+ K + GK T D+GG S T ++ +VI +L Sbjct: 342 SSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>O29627:LEU3_ARCFU 3-isopropylmalate dehydrogenase - Archaeoglobus fulgidus| Length = 326 Score = 265 bits (676), Expect = 4e-70 Identities = 144/327 (44%), Positives = 215/327 (65%), Gaps = 1/327 (0%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDV-TPSLNADGKTVIPDESIASIKRNY 373 + +I GDGIG E+ ++ I ++P ++ D +L GK +PDE++ + +++ Sbjct: 4 IVVIPGDGIGKEVMEAAMLILEKLDLPFEYSYYDAGDEALEKYGKA-LPDETLEACRKSD 62 Query: 374 VALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENTEGE 553 L G G+ + + LRR FANVRP K+I+G + Y +D V++RENTE Sbjct: 63 AVLFGAA----GETAADVIVRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTECL 118 Query: 554 YSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFL 733 Y G E D V ++I++ITREASER+ R+AF+ A+ G+ KV +HKA +MK + GLF Sbjct: 119 YMGFEFGFGD-VTEAIRVITREASERIARYAFELAKREGRKKVTALHKANVMKKTCGLFR 177 Query: 734 NLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGL 913 ++ RE+AK+YP I+++ +D AC+ +V DP ++ V+V N++GDI+SD+ AGL+GGL Sbjct: 178 DVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFD--VIVTTNMFGDIVSDLAAGLVGGL 235 Query: 914 GLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAI 1093 GL PS N+G+ +IFE VHG+A DIAGKG+ANPTA++L++ MML+H G E A K++ A+ Sbjct: 236 GLAPSANVGERTAIFEPVHGAAFDIAGKGIANPTAMILTACMMLRHFGYVEEAKKVEEAV 295 Query: 1094 FKTLAEGKTITGDLGGKSKTHEYAAAV 1174 KT+ EGK T DLGG KT E+A V Sbjct: 296 EKTIKEGKK-TPDLGGNLKTMEFANEV 321
>Q93353:IDH3B_CAEEL Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial| precursor - Caenorhabditis elegans Length = 379 Score = 253 bits (645), Expect = 2e-66 Identities = 139/337 (41%), Positives = 215/337 (63%), Gaps = 7/337 (2%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKR 367 K V++I GDG+GPE+ +V+DI +PI++E I ++ ++ + ++ SI R Sbjct: 42 KLKVTIIPGDGVGPELIYTVQDIVKQTGIPIEFEEIFLSEVHYTRSSSI--ENAVESIGR 99 Query: 368 NY-VALKGPL---ATPIGKGHVS-LNLTLRRTFNLFANVRPCKSIQGYKTPYDN-VDTVL 529 N VALKG + A +G + LN+ LRR+ +LFANV K++ G KT + +D V+ Sbjct: 100 NNNVALKGAIEESAVLHTEGELQGLNMRLRRSLDLFANVVHIKTLDGIKTRHGKQLDFVI 159 Query: 530 IRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIM 709 +RE TEGEYS +EH +V GV++ +K+ TR +ER+ +FAF YA G+ KV VHKA IM Sbjct: 160 VREQTEGEYSSLEHELVPGVIECLKISTRTKAERIAKFAFDYATKTGRKKVTAVHKANIM 219 Query: 710 KMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDM 889 K+ DGLFL +AK+YP I+F++ ++DN C+++V+ P ++ V+VMPNLYG+I+ ++ Sbjct: 220 KLGDGLFLRTCEGVAKQYPKIQFESMIIDNTCMQLVSKPEQFD--VMVMPNLYGNIIDNL 277 Query: 890 CAGLIGGLGLTPSGNIGDECSIFE-AVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFE 1066 AGL+GG G+ P ++G + IFE S + G+ +ANPTA++L + ML H+ L Sbjct: 278 AAGLVGGAGVVPGQSVGRDFVIFEPGSRHSFQEAMGRSIANPTAMILCAANMLNHLHLDA 337 Query: 1067 HANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVI 1177 N ++ A+ + EGK T DLGG + T ++A AVI Sbjct: 338 WGNSLRQAVADVVKEGKVRTRDLGGYATTVDFADAVI 374
>O27441:LEU3_METTH 3-isopropylmalate dehydrogenase - Methanobacterium| thermoautotrophicum Length = 329 Score = 251 bits (641), Expect = 5e-66 Identities = 138/330 (41%), Positives = 207/330 (62%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 +++I GDGIG E+ ++ I + ++ +++ D + T +P+E++ ++ Sbjct: 6 IAVIPGDGIGVEVMEAALHILNTLDLDLEFIHADAGDACLKRTGTALPEETLEAVGEARA 65 Query: 377 ALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENTEGEY 556 L G G+ + + LRR F+LFAN+RP KS+ G Y ++D V++RENTE Y Sbjct: 66 TLFGAA----GESAADVIVRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENTEDLY 121 Query: 557 SGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLN 736 G E +G V ++ITR AS R+ +FAFQYAQ G KV VHKA ++K +DG+F + Sbjct: 122 VGDEEYTPEGAVAK-RIITRTASRRISQFAFQYAQKEGMQKVTAVHKANVLKKTDGIFRD 180 Query: 737 LGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLG 916 ++A EYP +E +D + ++T P + + +V NL+GDILSD AGLIGGLG Sbjct: 181 EFYKVASEYPQMEATDYYVDATAMYLITQPQEF--QTIVTTNLFGDILSDEAAGLIGGLG 238 Query: 917 LTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIF 1096 L PS NIG++ ++FE VHGSAP IAGK +ANPTA++L++ +ML+H+ + A KI+ A+ Sbjct: 239 LAPSANIGEKNALFEPVHGSAPQIAGKNIANPTAMILTTTLMLKHLNKKQEAQKIEKALQ 298 Query: 1097 KTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 KTLAEG +T DLGGK T E AA + ++L Sbjct: 299 KTLAEG-LVTPDLGGKLGTMEMAAEIARHL 327
>Q1RJU4:ICD_RICBR Isocitrate dehydrogenase [NADP] - Rickettsia bellii (strain RML369-C)| Length = 483 Score = 244 bits (622), Expect = 8e-64 Identities = 143/338 (42%), Positives = 209/338 (61%), Gaps = 8/338 (2%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADG-KTVIPDESIASIKRNY 373 +++ GDGIGPEI ++V I A I+ E+I+V L + I ++S SI+R Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYVKHYSSGISEQSWESIERTG 66 Query: 374 VALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY-KTPYDNVDTVLIRENTEG 550 V LK P+ TP G G+ SLN+T+R+T LFAN+RP S + KT + N++ +IREN E Sbjct: 67 VILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFYPFTKTLHPNLNLTIIRENEED 126 Query: 551 EYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLF 730 Y+GIE+ + +S+KLI+R E+++R+AF+YA + KV + K IMK SDG+F Sbjct: 127 LYAGIEYRQTHNMYESVKLISRTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGIF 186 Query: 731 LNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGG 910 + EIAKEYP I + ++D ++ T P ++ V+V NLYGDI+SD+ A + G Sbjct: 187 HKVFNEIAKEYPQINNEHYIIDIGTARLATKPEIFD--VIVTSNLYGDIISDVAAEISGS 244 Query: 911 LGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAA 1090 +GL S NIG+ ++FEAVHGSAPDIAG+ +ANP+ LL ++IMML H+G + A I+ A Sbjct: 245 VGLAGSANIGEHYAMFEAVHGSAPDIAGQDIANPSGLLNAAIMMLVHIGQGDIATLIENA 304 Query: 1091 IFKTLAEGKTITGDLGGKSK------THEYAAAVIKNL 1186 KT+ +G T D+ K T E+A V+K L Sbjct: 305 WKKTIEDGMH-TADIYNKDHSTKKVGTKEFAEEVVKRL 341
>Q68XA5:IDH_RICTY Isocitrate dehydrogenase [NADP] - Rickettsia typhi| Length = 483 Score = 239 bits (610), Expect = 2e-62 Identities = 143/338 (42%), Positives = 206/338 (60%), Gaps = 8/338 (2%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTV-IPDESIASIKRNY 373 +++ GDGIGPEI +V I A I E+I+V L T I +ES I+R Sbjct: 7 ITIAYGDGIGPEIMDAVLYILRQAEARISLETIEVGEKLYKKHYTSGISEESWNVIQRTG 66 Query: 374 VALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY-KTPYDNVDTVLIRENTEG 550 + LK P+ TP G+ SLN+T+R+T LFAN+RP S + +T + N++ +IREN E Sbjct: 67 IILKAPITTPQSGGYKSLNVTIRKTLQLFANIRPAVSFHPFTRTLHPNLNLTIIRENEED 126 Query: 551 EYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLF 730 YSGIE+ + +S+KLI+ ++++R+AF+YA + KV + K IMK SDG+F Sbjct: 127 LYSGIEYRQTHNMYESLKLISHTGCKKIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGIF 186 Query: 731 LNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGG 910 + EIAKEYP I+ + ++D K+ T P ++ ++V NLYGDI+SD+ A + G Sbjct: 187 HRVFNEIAKEYPQIDNEHYIIDIGTAKLATTPEIFD--IIVTSNLYGDIISDVAAEISGS 244 Query: 911 LGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAA 1090 +GL S NIG ++FEAVHGSAPDIAGKG+ANP+ LL ++IMML H+G + A+ I+ A Sbjct: 245 VGLAGSANIGQHYAMFEAVHGSAPDIAGKGIANPSGLLNAAIMMLVHIGQGDIASLIENA 304 Query: 1091 IFKTLAEGKTITGDL------GGKSKTHEYAAAVIKNL 1186 KT+ +G T D+ K T E+A VIK L Sbjct: 305 WKKTIEDG-VHTFDIYSEHSSSKKVCTKEFAEEVIKRL 341
>Q4UKR1:ICD_RICFE Isocitrate dehydrogenase [NADP] - Rickettsia felis (Rickettsia azadi)| Length = 483 Score = 239 bits (609), Expect = 3e-62 Identities = 143/338 (42%), Positives = 206/338 (60%), Gaps = 8/338 (2%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTV-IPDESIASIKRNY 373 +++ GDGIGPEI ++V I A I+ E+I+V L T I +ES SI+R Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTG 66 Query: 374 VALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYK-TPYDNVDTVLIRENTEG 550 + LK P+ TP G G+ SLN+T+R+T LFAN+RP S + T + +++ +IREN E Sbjct: 67 IILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFHPFTMTLHPHLNLTIIRENEED 126 Query: 551 EYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLF 730 Y+GIE+ + +SIKLI+ E+++R+AF+YA + KV + K IMK SDG+F Sbjct: 127 LYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIMKFSDGVF 186 Query: 731 LNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGG 910 + EIAKEYP I + ++D ++ T P ++ V+V NLYGDI+SD+ A + G Sbjct: 187 HKIFNEIAKEYPQINNEHYIIDIGTARLATKPEIFD--VIVTSNLYGDIISDVAAEISGS 244 Query: 911 LGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAA 1090 +GL S NIG ++FEAVHGSAPDIAGK +ANP+ LL ++IMML H+G + A+ I+ A Sbjct: 245 VGLAGSANIGQHYAMFEAVHGSAPDIAGKDIANPSGLLNAAIMMLVHIGQGDIASLIENA 304 Query: 1091 IFKTLAEGKTITGDL------GGKSKTHEYAAAVIKNL 1186 KT+ +G T D+ K T E+A V K L Sbjct: 305 WKKTIEDG-VHTADIYNEQNSSKKVGTKEFAEEVTKRL 341
>Q9ZDR0:IDH_RICPR Isocitrate dehydrogenase [NADP] - Rickettsia prowazekii| Length = 483 Score = 237 bits (605), Expect = 8e-62 Identities = 142/338 (42%), Positives = 206/338 (60%), Gaps = 8/338 (2%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTV-IPDESIASIKRNY 373 +++ GDGIGPEI ++V I A I E+I+V L T I +ES I+R Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARISLETIEVGEKLYKKHYTSGISEESWDVIQRTG 66 Query: 374 VALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY-KTPYDNVDTVLIRENTEG 550 + LK P+ TP G+ SLN+T+R+T LFAN+RP S + +T + N++ +IREN E Sbjct: 67 IILKAPITTPQSGGYKSLNVTIRKTLQLFANIRPVVSFYPFTRTLHPNLNLTIIRENEED 126 Query: 551 EYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLF 730 YSG+E+ + +S+KLI+ ++++R+AF+YA + KV + K IMK SDG+F Sbjct: 127 LYSGVEYRQTHNMYESMKLISHTGCKKIIRYAFEYAIKNNRKKVTCLTKDNIMKFSDGIF 186 Query: 731 LNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGG 910 + EIAKEYP I + ++D K+ T P ++ ++V NLYGDI+SD+ A + G Sbjct: 187 HRVFNEIAKEYPQINNEHYIIDIGTAKLATKPEIFD--IIVTSNLYGDIISDVAAEISGS 244 Query: 911 LGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAA 1090 +GL S NIG ++FEAVHGSAPDIAGKG+ANP+ LL ++IMML H+G + A+ I+ A Sbjct: 245 VGLAGSANIGQHYAMFEAVHGSAPDIAGKGIANPSGLLNAAIMMLVHIGQGDIASLIENA 304 Query: 1091 IFKTLAEGKTITGDL------GGKSKTHEYAAAVIKNL 1186 KT+ +G T D+ K T E+A VIK L Sbjct: 305 WKKTIEDG-VHTFDIYNEHSSSKKVCTKEFAVEVIKRL 341
>Q92IR7:IDH_RICCN Isocitrate dehydrogenase [NADP] - Rickettsia conorii| Length = 483 Score = 237 bits (605), Expect = 8e-62 Identities = 142/338 (42%), Positives = 205/338 (60%), Gaps = 8/338 (2%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTV-IPDESIASIKRNY 373 +++ GDGIGPEI ++V I A I+ E+I+V L T I +ES SI+R Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYKKHYTSGISEESWESIQRTG 66 Query: 374 VALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY-KTPYDNVDTVLIRENTEG 550 + LK P+ TP G G+ SLN+T+R+T LFAN+RP S+ + +T + N++ +IREN E Sbjct: 67 IILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPAVSLHPFTRTLHPNLNLTIIRENEED 126 Query: 551 EYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLF 730 Y+GIE+ + +S+KLI+ E+++R+AF+YA + KV + K IMK SDG+ Sbjct: 127 LYAGIEYRQTHNMYESMKLISHTGCEKIIRYAFEYAVKNNRKKVMCLSKDNIMKFSDGVL 186 Query: 731 LNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGG 910 + EIAKEYP I ++D ++ T P ++ V+V NLYGDI+SD+ A + G Sbjct: 187 HKVFNEIAKEYPQINNAHYIIDIGTARLATKPEIFD--VIVTSNLYGDIISDVAAEISGS 244 Query: 911 LGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAA 1090 +GL S NIG ++FEAVHGSAPDIAGK +ANP+ LL ++IMML H+G + A I+ A Sbjct: 245 VGLAGSANIGQHYAMFEAVHGSAPDIAGKDIANPSGLLNAAIMMLVHIGQGDIATLIENA 304 Query: 1091 IFKTLAEGKTITGDL------GGKSKTHEYAAAVIKNL 1186 KT+ +G T D+ K T E+A V K L Sbjct: 305 WKKTIEDG-VHTADIYNEQSSSKKVGTKEFAEEVTKRL 341
>Q58130:LEU3_METJA 3-isopropylmalate dehydrogenase - Methanococcus jannaschii| Length = 333 Score = 236 bits (602), Expect = 2e-61 Identities = 132/336 (39%), Positives = 206/336 (61%), Gaps = 4/336 (1%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRN 370 + + +IEGDGIG E+ + + A +P ++ + + +P+E+I + Sbjct: 2 HKICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAGDEVYKRTGKALPEETIETALDC 61 Query: 371 YVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENTEG 550 L G G+ + + LR + +AN+RP K+ +G K ++D V++RENTEG Sbjct: 62 DAVLFGAA----GETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYVIVRENTEG 117 Query: 551 EYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQD---IGKP-KVRVVHKATIMKMS 718 Y GIE + +G+ + ++IT +A ER+ RFAF A++ +GK KV HKA ++K++ Sbjct: 118 LYKGIEAEIDEGITIATRVITEKACERIFRFAFNLARERKKMGKEGKVTCAHKANVLKLT 177 Query: 719 DGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 DGLF + ++A+EY +I+ + +D + ++T P ++ V+V NL+GDILSD AG Sbjct: 178 DGLFKKIFYKVAEEYDDIKAEDYYIDAMNMYIITKPQVFD--VVVTSNLFGDILSDGAAG 235 Query: 899 LIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANK 1078 +GGLGL PS NIGDE +FE VHGSAPDIAGK +ANPTA +LS+++ML+++G +E A+K Sbjct: 236 TVGGLGLAPSANIGDEHGLFEPVHGSAPDIAGKKIANPTATILSAVLMLRYLGEYEAADK 295 Query: 1079 IQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 ++ A+ + LA G T T DLGG T E A V K + Sbjct: 296 VEKALEEVLALGLT-TPDLGGNLNTFEMAEEVAKRV 330
>P50455:LEU3_SULTO 3-isopropylmalate dehydrogenase - Sulfolobus tokodaii| Length = 337 Score = 228 bits (581), Expect = 5e-59 Identities = 132/343 (38%), Positives = 198/343 (57%), Gaps = 11/343 (3%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDESIAS 358 +TV+LI+GDGIGPEI K I + N +PI++ ++ A +P +S+ Sbjct: 3 FTVALIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEVEAGDRALARYGEALPKDSLKI 62 Query: 359 IKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRE 538 I + + LKGP +G+ + + LR+ ++++AN+RP KSI G T Y NVD +++RE Sbjct: 63 IDKADIILKGP----VGESAADVVVKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVRE 118 Query: 539 NTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMS 718 NTE Y G EH+V DGV +K+ITR ASER+ + +A K KV VHKA +M+++ Sbjct: 119 NTEDLYKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFALRRRK-KVTCVHKANVMRIT 177 Query: 719 DGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 DGLF R + K +E+ +D A +V +P ++ V+V N+YGDILSD + Sbjct: 178 DGLFAEACRSVLK--GKVEYSEMYVDAAAANLVRNPQMFD--VIVTENVYGDILSDEASQ 233 Query: 899 LIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHM-------G 1057 + G LG+ PS NIGD+ ++FE VHG+A DIAGK + NPTA LLS MM + M Sbjct: 234 IAGSLGIAPSANIGDKKALFEPVHGAAFDIAGKNIGNPTAFLLSVSMMYERMYELSNDDR 293 Query: 1058 LFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 + + ++ AI+ E K +T D+GG + T + + L Sbjct: 294 YIKASRALENAIYLVYKERKALTPDVGGNATTDDLINEIYNKL 336
>Q9UXB2:LEU3_SULSO 3-isopropylmalate dehydrogenase - Sulfolobus solfataricus| Length = 336 Score = 221 bits (564), Expect = 4e-57 Identities = 138/344 (40%), Positives = 204/344 (59%), Gaps = 14/344 (4%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDI-------YSAANVPIKWESIDVTPSLNADGKTVIPDES 349 + V++I GDGIGPE+ + K I Y+ I+ E+ DV +LN G+ +P + Sbjct: 3 FRVAVIPGDGIGPELYEGSKRIIAKLIEKYNLDIDLIEVEAGDV--ALNKYGEA-LPRHT 59 Query: 350 IASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVL 529 + I++ + LKGP +G+ + + + LR+ ++++AN+RP KS+ ++ Y NVD V+ Sbjct: 60 LDVIEKADMILKGP----VGETAMDVVVKLRQMYDMYANIRPAKSLPNVQSKYPNVDLVI 115 Query: 530 IRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIM 709 +RENTE Y G E V GV +IK+ T AS+R++ A YA + + KV VHKA +M Sbjct: 116 VRENTEDLYKGFEFVTSTGVTIAIKVTTEFASKRIVNVALNYAL-MRRRKVTCVHKANVM 174 Query: 710 KMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDM 889 +++DGLF ++ REI K + F+ +D A +V DPT ++ V+V N+YGDILSD Sbjct: 175 RVTDGLFASVCREILKG--KVNFEEMYVDAAAANLVRDPTRFD--VIVTSNVYGDILSDE 230 Query: 890 CAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEH 1069 + + G LGL PS NIGD S+FE VHG+A DIAGKG+ANPTA LLS MML M Sbjct: 231 ASQIAGSLGLAPSANIGDRKSMFEPVHGAAFDIAGKGIANPTAFLLSVSMMLSRMYELSK 290 Query: 1070 ANK-------IQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIK 1180 NK ++ AI +T G +T D+GG +K + + K Sbjct: 291 ENKYILASKSLENAIIETYKSGNKLTEDVGGSAKLKDMVDEIYK 334
>Q58991:AKSF_METJA Threo-isocitrate dehydrogenase [NAD] - Methanococcus jannaschii| Length = 347 Score = 216 bits (549), Expect = 2e-55 Identities = 135/342 (39%), Positives = 201/342 (58%), Gaps = 15/342 (4%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGK--TVIPDESIASIKRN 370 V +IEGDGIG E+ + + N ++E I L K +P+++I K Sbjct: 4 VCVIEGDGIGKEV---IPEAIKILNELGEFEIIKGEAGLECLKKYGNALPEDTIEKAKEA 60 Query: 371 YVALKGPLATPIG---KGHVSLNLTLRRTFNLFANVRPCKS-----IQGYKTPYD----- 511 + L G + +P + + S +TLR+ F+L+ANVRP + + G Y+ Sbjct: 61 DIILFGAITSPKPGEVQNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIADYEFLNAK 120 Query: 512 NVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVV 691 N+D V+IRENTE Y G E + D + ++ITR+ SER++RFAF+YA + KV + Sbjct: 121 NIDIVIIRENTEDLYVGRERLENDTAIAE-RVITRKGSERIIRFAFEYAIKNNRKKVSCI 179 Query: 692 HKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYG 871 HKA +++++DGLFL + EI K Y NIE D L+D+ + ++ P ++ V+V N++G Sbjct: 180 HKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPEKFD--VIVTTNMFG 236 Query: 872 DILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQH 1051 DILSD + LIGGLGL PS NIGD+ ++FE VHGSAPDIAGKG+ANP A +LS M+ + Sbjct: 237 DILSDEASALIGGLGLAPSANIGDDKALFEPVHGSAPDIAGKGIANPMASILSIAMLFDY 296 Query: 1052 MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVI 1177 +G E + I+ A+ K K +T DLGG KT + ++ Sbjct: 297 IGEKEKGDLIREAV-KYCLINKKVTPDLGGDLKTKDVGDEIL 337
>P40495:LYS12_YEAST Homoisocitrate dehydrogenase, mitochondrial precursor - Saccharomyces| cerevisiae (Baker's yeast) Length = 371 Score = 203 bits (516), Expect = 2e-51 Identities = 136/377 (36%), Positives = 204/377 (54%), Gaps = 20/377 (5%) Frame = +2 Query: 116 FQIVQSRFASSQVAAFQGQKGSDGKYTVSLIEGDGIGPEIAQSVKDIYSAANVP--IKWE 289 F+ V +R ++ + A + S T+ LI GDGIG E+ + K + N + + Sbjct: 2 FRSVATRLSACRGLASNAARKS---LTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFN 58 Query: 290 SIDVTPSLNADGKT--VIPDESIASIKRNYV-ALKGPLATPIGK--GHVSLNLTLRRTFN 454 ID+ +T +PDE++ +K AL G + +P K G+ S + LRR Sbjct: 59 FIDLYAGFQTFQETGKALPDETVKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMG 118 Query: 455 LFANVRPCKSIQGYKTPYDNVDTVLIRENTEGEYSGIEHVVVDG-----VVQSIKLITRE 619 LFANVRP KS++G K +D V++RENTE Y IE +D V + K I+ Sbjct: 119 LFANVRPVKSVEGEKGK--PIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEI 176 Query: 620 ASERVLRFAFQYA----QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAK----EYPNIE 775 A+ R+ A A Q G+ + V HK+ ++ SDGLF + +E+ + +Y I+ Sbjct: 177 ATRRIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIK 236 Query: 776 FDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSI 955 ++ +++D+ ++ +P ++ V+V PNLYGDILSD A L+G LG+ PS N+G E I Sbjct: 237 YNEQIVDSMVYRLFREPQCFD--VIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIVI 294 Query: 956 FEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDL 1135 E HGSAPDIAGKG+ANP A + S+ +ML+ +G E A I A+ L EG T DL Sbjct: 295 GEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDANLREGSIKTPDL 354 Query: 1136 GGKSKTHEYAAAVIKNL 1186 GGK+ T + V+ L Sbjct: 355 GGKASTQQVVDDVLSRL 371
>O29610:IDH_ARCFU Isocitrate dehydrogenase [NADP] - Archaeoglobus fulgidus| Length = 412 Score = 197 bits (500), Expect = 1e-49 Identities = 132/383 (34%), Positives = 200/383 (52%), Gaps = 53/383 (13%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTV----IPDESIASIK 364 + EGDGIG ++ + + AA I E + D + +PD+++ +IK Sbjct: 30 IPYFEGDGIGKDVVPAAIRVLDAAADKIGKEVVWFQVYAGEDAYKLYGNYLPDDTLNAIK 89 Query: 365 RNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY---DNVDTVLIR 535 VALKGPL TP+G G+ SLN+T+R+ +L+ANVRP ++G +P + V+ V+ R Sbjct: 90 EFRVALKGPLTTPVGGGYRSLNVTIRQVLDLYANVRPVYYLKGVPSPIKHPEKVNFVIFR 149 Query: 536 ENTEGEYSGIEH--------------------VVVDGVVQSIKLITREASERVLRFAFQY 655 ENTE Y+GIE + + IK I+ A++R++R A +Y Sbjct: 150 ENTEDVYAGIEWPRGSEEALKLIRFLKNEFGVTIREDSGIGIKPISEFATKRLVRMAIRY 209 Query: 656 AQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAK----EY-----------------PNI 772 A + + V +VHK IMK ++G F + G E+AK EY I Sbjct: 210 AIENNRKSVTLVHKGNIMKYTEGAFRDWGYEVAKQEFGEYCITEDELWDKYGGKQPEGKI 269 Query: 773 EFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECS 952 + DN +++T Y+ V+ +PNL GD LSD A LIGGLG+ P NIGD Sbjct: 270 VVKDRIADNMFQQILTRTDEYD--VIALPNLNGDYLSDAAAALIGGLGIAPGSNIGDGIG 327 Query: 953 IFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGD 1132 +FE VHGSAP AG+ NPTA +L+ +M +++G + + I+ A+ T++ G +T D Sbjct: 328 VFEPVHGSAPKYAGQNKVNPTAEILTGALMFEYIGWKDASEMIKKAVEMTISSG-IVTYD 386 Query: 1133 L-----GGKSKTHEYAAAVIKNL 1186 + G K T E+A AV++NL Sbjct: 387 IHRHMGGTKVGTREFAEAVVENL 409
>O67480:IDH_AQUAE Isocitrate dehydrogenase [NADP] - Aquifex aeolicus| Length = 426 Score = 190 bits (483), Expect = 1e-47 Identities = 127/356 (35%), Positives = 190/356 (53%), Gaps = 51/356 (14%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDVTPSLNADGKTV--IPDES 349 + IEGDGIGPEI Q++ I + A + I W +++ A+ KT +P E+ Sbjct: 41 IPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYW--VELLAGDKAEEKTGERLPQET 98 Query: 350 IASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDN---VD 520 + +K + V +KGPL TP+GKG S+N LRR F+ ++ VRP + G TP N VD Sbjct: 99 LDVLKESIVGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPVYWM-GQATPIPNPERVD 157 Query: 521 TVLIRENTEGEYSGIEHVV-------------------VDGVVQSIKLITREASE----R 631 V+ RENT+ Y+G+E +G + + + + SE R Sbjct: 158 LVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTKR 217 Query: 632 VLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYP--------------- 766 +R A +YA + K V V+ K IMK ++G F+N E+A+E Sbjct: 218 HVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVVTDPEAEPGE 277 Query: 767 -NIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD 943 ++ + D +++V P ++ V++ NL GD +SD+ A LIGG G PSGNIGD Sbjct: 278 GQVKLTKVITDQMLMQLVLKPEAWD--VIIAQNLNGDYVSDLAASLIGGPGFVPSGNIGD 335 Query: 944 ECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIFKTLAE 1111 ++FE+ HG+A DIAGKG+ANP +L LS MML+++G E A K+ A+ +TLAE Sbjct: 336 GYALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEYIGWKEAAQKVYDAVRRTLAE 391
>P94631:LEU3_CORGL 3-isopropylmalate dehydrogenase - Corynebacterium glutamicum| (Brevibacterium flavum) Length = 340 Score = 190 bits (482), Expect = 1e-47 Identities = 118/318 (37%), Positives = 181/318 (56%), Gaps = 14/318 (4%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 +++I GDGIGPE+ + +A I+ D+ ++ DE +AS++ + Sbjct: 3 LAVIGGDGIGPEVTAEALKVLNAVRDDIETTDYDLGARRYLKNGELLTDEDLASLREHDA 62 Query: 377 ALKGPLATP--IGKGHVSLNLTLRRTFNL--FANVRPCKSIQGYKTPYDN---VDTVLIR 535 L G + P + G + L L+ F L N+RP K G ++P N +D V++R Sbjct: 63 ILLGAIGAPGSVPPGILERGLLLKMRFALDHHVNLRPSKLYDGVESPLRNPGKIDFVVVR 122 Query: 536 ENTEGEYSGIEHVVVDGVVQSI----KLITREASERVLRFAFQYAQDIGKPKVRVVHKAT 703 E TEG Y+G + G I + TR +ERV+R+AF+ AQ K K+ +VHK Sbjct: 123 EGTEGAYTGNGGAIRVGTPHEIANETSVNTRYGAERVIRYAFELAQSRRK-KLTLVHKTN 181 Query: 704 IMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILS 883 ++ GL+ E+AKEYP + D +D A + +VTDP+ ++ V+V NL+GDIL+ Sbjct: 182 VLVHGGGLWQRTVDEVAKEYPEVAVDYNHIDAATIYLVTDPSRFD--VIVTDNLFGDILT 239 Query: 884 DMCAGLIGGLGLTPSGNI---GDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHM 1054 D + GG+GL SGNI G S+FE VHGSAPDIAG+G+A+PTA +LS+ M+L+H+ Sbjct: 240 DEAGAVSGGIGLAASGNIDATGTNPSMFEPVHGSAPDIAGQGIADPTAAILSAAMLLRHL 299 Query: 1055 GLFEHANKIQAAIFKTLA 1108 G ++A +I+ AI +A Sbjct: 300 GDEDNAVRIETAIAADVA 317
>Q8FPV5:LEU3_COREF 3-isopropylmalate dehydrogenase - Corynebacterium efficiens| Length = 340 Score = 185 bits (470), Expect = 3e-46 Identities = 118/341 (34%), Positives = 186/341 (54%), Gaps = 14/341 (4%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 +++I GDGIGPE+ + A I+ +D+ ++ DE +A ++ + Sbjct: 3 LAVIGGDGIGPEVTDEALKVLRALRADIETTDLDLGARRYLRNGELLTDEDLALLREHDA 62 Query: 377 ALKGPLATP--IGKGHVSLNLTLRRTFNL--FANVRPCKSIQGYKTPYDN---VDTVLIR 535 L G + P + G + L L+ F L N+RP K +G ++P N +D V++R Sbjct: 63 ILLGAIGAPGSVPPGVLERGLLLKLRFALDHHVNLRPSKLYEGVESPLKNPGEIDFVVVR 122 Query: 536 ENTEGEYSGIEHVVVDGV----VQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKAT 703 E TEG Y+G + G + TR +ERV+R+AF+ AQ + + +VHK Sbjct: 123 EGTEGAYTGNGGAIRVGTPHETANETSVNTRYGAERVIRYAFELAQS-RRRHLTLVHKTN 181 Query: 704 IMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILS 883 ++ GL+ E+A+EYP + D +D A + +VTDP+ ++ V+V NL+GDIL+ Sbjct: 182 VLVHGGGLWQRTVDEVAREYPEVTVDYNHIDAATIYLVTDPSRFD--VIVTDNLFGDILT 239 Query: 884 DMCAGLIGGLGLTPSGNI---GDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHM 1054 D + GG+GL SGNI G S+FE VHGSAPDI GKG+A+PTA +LS+ MML+H+ Sbjct: 240 DEAGAISGGIGLAASGNIDATGTNPSMFEPVHGSAPDIMGKGIADPTAAILSAAMMLRHL 299 Query: 1055 GLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVI 1177 G +A +I+ A+ + +A G+ + AAAV+ Sbjct: 300 GDEANAVRIEEAVARDVA-GRDPEAPISTTEVGDRIAAAVV 339
>Q6NHM7:LEU3_CORDI 3-isopropylmalate dehydrogenase - Corynebacterium diphtheriae| Length = 339 Score = 180 bits (456), Expect = 1e-44 Identities = 115/319 (36%), Positives = 177/319 (55%), Gaps = 14/319 (4%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 +++I GDGIGPE+ + +A I+ D+ ++ D + S++ + Sbjct: 3 LAVIGGDGIGPEVTAEALKVLNAVRDDIEVTDYDLGARRYLRNGELLADADLVSLREHDA 62 Query: 377 ALKGPLATP--IGKGHVSLNLTLRRTFNL--FANVRPCKSIQGYKTPYDN---VDTVLIR 535 L G + P + G + L L+ F L N+RP K +P N +D V++R Sbjct: 63 ILLGAIGAPGEVPPGVLERGLLLKMRFALDHHVNLRPSKLYPTATSPLANPGDIDFVVVR 122 Query: 536 ENTEGEYSGIEHVVVDG----VVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKAT 703 E TEG Y G + +G + + TR ERV+R AF+ AQ+ K + +VHK Sbjct: 123 EGTEGLYCGNGGTLREGTPHEIASEVSQNTRYGVERVVRDAFERAQN-RKKHLTLVHKTN 181 Query: 704 IMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILS 883 ++ + GL+ EIA EYP + D +D A + +VTDP+ Y+ V+V NL+GDIL+ Sbjct: 182 VLVNAGGLWQRTVNEIATEYPEVTVDYNHIDAATIYMVTDPSRYD--VIVTDNLFGDILT 239 Query: 884 DMCAGLIGGLGLTPSGNI---GDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHM 1054 D+ + GG+GL SGNI G S+FE VHGSAPDIAG+G+A+PTA +LS+ M+L+H+ Sbjct: 240 DLAGAVTGGIGLAASGNIDATGVNPSMFEPVHGSAPDIAGQGIADPTAAILSAAMLLRHV 299 Query: 1055 GLFEHANKIQAAIFKTLAE 1111 G +A +I+AA+ +AE Sbjct: 300 GDESNAQRIEAAVTYDVAE 318
>P41560:IDH1_COLMA Isocitrate dehydrogenase [NADP] 1 - Colwellia maris (Vibrio sp.| (strain ABE-1)) Length = 415 Score = 178 bits (451), Expect = 5e-44 Identities = 124/360 (34%), Positives = 180/360 (50%), Gaps = 65/360 (18%) Frame = +2 Query: 182 DGKYTVS------LIEGDGIGPEIAQSVKDIYSAANVPI-----KWESIDVTPSLNA--- 319 DGK +V IEGDGIG ++ + + +AA K E ++V A Sbjct: 18 DGKLSVPNNPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKM 77 Query: 320 -DGKTVIPDESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY 496 D +T +P+E++ ++ V++KGPL TP+G G SLN+ +R+ +L+ RP + G Sbjct: 78 YDSETWLPEETLNILQEYKVSIKGPLTTPVGGGMSSLNVAIRQMLDLYVCQRPVQWFTGV 137 Query: 497 KTPY---DNVDTVLIRENTEGEYSGIEHVVVDGVVQS----------------------- 598 +P VD V+ RENTE Y+GIE+ +S Sbjct: 138 PSPVKRPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFTENCGIG 197 Query: 599 IKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEF 778 IK +++E S+R++R A QYA D K V +VHK IMK ++G F + G E+A E EF Sbjct: 198 IKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAIE----EF 253 Query: 779 DAELL------------------------DNACLKVVTDPTPYNDKVLVMPNLYGDILSD 886 A LL D +V+ P Y+ V+ NL GD LSD Sbjct: 254 GASLLHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYS--VIATLNLNGDYLSD 311 Query: 887 MCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFE 1066 A +GG+G+ P N+GDE ++FEA HG+AP AGK NP +++LS+ MML+HMG E Sbjct: 312 ALAAQVGGIGIAPGANLGDEVAVFEATHGTAPKYAGKNKVNPGSVILSAEMMLRHMGWLE 371
>P08200:IDH_ECOLI Isocitrate dehydrogenase [NADP] - Escherichia coli| Length = 416 Score = 176 bits (447), Expect = 2e-43 Identities = 129/393 (32%), Positives = 194/393 (49%), Gaps = 63/393 (16%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDV-TPSLNADGKTV-IPDES 349 + IEGDGIG ++ ++ + AA I W I S G+ V +P E+ Sbjct: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 Query: 350 IASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDN---VD 520 + I+ VA+KGPL TP+G G SLN+ LR+ +L+ +RP + QG +P + D Sbjct: 89 LDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 148 Query: 521 TVLIRENTEGEYSGIE----HVVVDGVVQ-------------------SIKLITREASER 631 V+ REN+E Y+GIE + V++ IK + E ++R Sbjct: 149 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 208 Query: 632 VLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLK 811 ++R A +YA + V +VHK IMK ++G F + G ++A+E EF EL+D Sbjct: 209 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE----EFGGELIDGGPWL 264 Query: 812 VVTDPT----------------------PYNDKVLVMPNLYGDILSDMCAGLIGGLGLTP 925 V +P P V+ NL GD +SD A +GG+G+ P Sbjct: 265 KVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAP 324 Query: 926 SGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIFKTL 1105 NIGDEC++FEA HG+AP AG+ NP +++LS+ MML+HMG E A+ I + + Sbjct: 325 GANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGM-EGA 383 Query: 1106 AEGKTITGDL-----GGK-SKTHEYAAAVIKNL 1186 KT+T D G K K E+ A+I+N+ Sbjct: 384 INAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
>Q47SB4:LEU3_THEFY 3-isopropylmalate dehydrogenase - Thermobifida fusca (strain YX)| Length = 354 Score = 176 bits (445), Expect = 3e-43 Identities = 118/326 (36%), Positives = 182/326 (55%), Gaps = 21/326 (6%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTP------SLNADGKTVIPDESIAS 358 +++I GDGIGPE+ + SA P ++D T +A G+ V+PD Sbjct: 8 LAVIPGDGIGPEVVAEGLKVLSAV-APRHGLTLDTTEYELGAQRWHATGE-VLPDAVEEE 65 Query: 359 IKRNYVALKGPLATP-IGKGHVSLNLTLRRTFNL--FANVRPCKSIQGYKTPY-----DN 514 ++++ L G + P + G + L LR FN + N+RP + G TP ++ Sbjct: 66 LRQHDAILLGAVGDPTVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGVAPED 125 Query: 515 VDTVLIRENTEGEYSGIEHVVVDGVVQSI----KLITREASERVLRFAFQYAQDIGKPKV 682 +D +++RE TEG Y+G+ V+ G I + TR ERV+R+AF A + K+ Sbjct: 126 IDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVERVVRYAFAKAAERPCHKL 185 Query: 683 RVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPN 862 +VHK ++ + L+ + RE+ EYP +E D +D A + VT P ++ V+V N Sbjct: 186 TLVHKDNVLTYAGELWQRVVREVGAEYPQVEVDYLHVDAATMFFVTQPRRFD--VVVTDN 243 Query: 863 LYGDILSDMCAGLIGGLGLTPSGNI---GDECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 L+GDI++D+ A + GG+GL SGNI GD S+FE VHGSAPDIAG+G A+PTA +LS Sbjct: 244 LFGDIITDLGAAVAGGIGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKADPTATILSV 303 Query: 1034 IMMLQHMGLFEHANKIQAAIFKTLAE 1111 +ML+H+G + A +I A+ + L E Sbjct: 304 SLMLEHLGYADAAAQIDQAVAEDLQE 329
>Q59940:IDH_STRMU Isocitrate dehydrogenase [NADP] - Streptococcus mutans| Length = 393 Score = 176 bits (445), Expect = 3e-43 Identities = 119/367 (32%), Positives = 191/367 (52%), Gaps = 42/367 (11%) Frame = +2 Query: 143 SSQVAAFQGQKGSDGKYTVSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDV 301 + +V+ +G+ K + IEGDG+G +I ++ + ++ A + + W + Sbjct: 2 AEKVSFEEGKLQVPDKPVIPYIEGDGVGQDIWKNAQIVFDKAIAKVYGGHKQVIWREVLA 61 Query: 302 TPSLNADGKTVIPDESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCK 481 + +P+E++ IK + +A+KGPL TP+G G SLN+ LR+ +LFA VRP + Sbjct: 62 GKKAYNETGNWLPNETLEIIKTHLLAIKGPLETPVGGGIRSLNVALRQELDLFACVRPVR 121 Query: 482 SIQGYKTPYDNVDTVLI---RENTEGEYSGIEHVVVDGVVQS------------------ 598 +G +P + + I RENTE Y+GIE VQ Sbjct: 122 YFKGVPSPLKHPEKTAITIFRENTEDIYAGIEWNAGTAEVQKVINFLQDDMQVKKIRFPK 181 Query: 599 -----IKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAK-E 760 IK I+ E S+R++R A +YA KV +VHK I K ++G F G E+AK E Sbjct: 182 SSSIGIKPISIEGSQRLIRAAIEYALANNLTKVTLVHKGNIQKFTEGGFRKWGYELAKRE 241 Query: 761 YP------NIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLT 922 Y + D + DN +++ P ++ V+ + NL GD SD A +GG+G++ Sbjct: 242 YAAELASGQLVVDDIIADNFLQQILLKPERFD--VVALTNLNGDYASDALAAQVGGIGIS 299 Query: 923 PSGNIGDEC--SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIF 1096 P NI + +IFEA HG+APDIAG+ LANP+++LLS M+ ++G + ++ I A+ Sbjct: 300 PGANINYQTGHAIFEATHGTAPDIAGQDLANPSSVLLSGCMLFDYIGWSKVSDLIMKAVE 359 Query: 1097 KTLAEGK 1117 K +A G+ Sbjct: 360 KAIANGQ 366
>Q8CNX4:IDH_STAES Isocitrate dehydrogenase [NADP] - Staphylococcus epidermidis (strain| ATCC 12228) Length = 422 Score = 175 bits (444), Expect = 4e-43 Identities = 131/404 (32%), Positives = 202/404 (50%), Gaps = 74/404 (18%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDVTPSLNADGKTVIPDESIA 355 + I GDGIGP+I ++ + AA I+W+ + + +P E++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAYDETGEWLPQETLE 80 Query: 356 SIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY---DNVDTV 526 +IK +A+KGPL TPIG G SLN+ LR+ +LF +RP + +G +P ++VD V Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPEDVDMV 140 Query: 527 LIRENTEGEYSGIE--------HVVVDGVVQ---------------SIKLITREASERVL 637 + RENTE Y+GIE V+D + IK +++E +ER++ Sbjct: 141 IFRENTEDIYAGIEFKQGTSEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIA-----------KEYPNI---- 772 R A QYA D + V +VHK IMK ++G F G ++A ++Y I Sbjct: 201 RAAIQYALDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAHNEFGDKVFTWQQYDEIVEQK 260 Query: 773 --------EFDAE----------LLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 + AE + D +++T P ++ V+ NL GD +SD A Sbjct: 261 GKDAANEAQSKAEQEGKIIIKDSIADIFLQQILTRPAEHD--VVATMNLNGDYISDALAA 318 Query: 899 LIGGLGLTPSGNIGDEC--SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHA 1072 +GG+G+ P NI E +IFEA HG+AP AG NP++ +LSS++ML+H+G E A Sbjct: 319 QVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSEILSSVLMLEHLGWQEAA 378 Query: 1073 NKIQAAIFKTLAEGKTITGDL-----GGKS-KTHEYAAAVIKNL 1186 +KI +I T+A K +T D G K T ++A +IKN+ Sbjct: 379 DKITDSIEATIA-SKIVTYDFARLMDGAKEVSTSDFADELIKNI 421
>Q5HNL1:IDH_STAEQ Isocitrate dehydrogenase [NADP] - Staphylococcus epidermidis (strain| ATCC 35984 / RP62A) Length = 422 Score = 175 bits (444), Expect = 4e-43 Identities = 131/404 (32%), Positives = 202/404 (50%), Gaps = 74/404 (18%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDVTPSLNADGKTVIPDESIA 355 + I GDGIGP+I ++ + AA I+W+ + + +P E++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAYDETGEWLPQETLE 80 Query: 356 SIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY---DNVDTV 526 +IK +A+KGPL TPIG G SLN+ LR+ +LF +RP + +G +P ++VD V Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPEDVDMV 140 Query: 527 LIRENTEGEYSGIE--------HVVVDGVVQ---------------SIKLITREASERVL 637 + RENTE Y+GIE V+D + IK +++E +ER++ Sbjct: 141 IFRENTEDIYAGIEFKQGTSEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIA-----------KEYPNI---- 772 R A QYA D + V +VHK IMK ++G F G ++A ++Y I Sbjct: 201 RAAIQYALDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAHNEFGDKVFTWQQYDEIVEQK 260 Query: 773 --------EFDAE----------LLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 + AE + D +++T P ++ V+ NL GD +SD A Sbjct: 261 GKDAANEAQSKAEQEGKIIIKDSIADIFLQQILTRPAEHD--VVATMNLNGDYISDALAA 318 Query: 899 LIGGLGLTPSGNIGDEC--SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHA 1072 +GG+G+ P NI E +IFEA HG+AP AG NP++ +LSS++ML+H+G E A Sbjct: 319 QVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSEILSSVLMLEHLGWQEAA 378 Query: 1073 NKIQAAIFKTLAEGKTITGDL-----GGKS-KTHEYAAAVIKNL 1186 +KI +I T+A K +T D G K T ++A +IKN+ Sbjct: 379 DKITDSIEATIA-SKIVTYDFARLMDGAKEVSTSDFADELIKNI 421
>Q48806:DLPA_LEGPH Protein dlpA - Legionella pneumophila subsp. pneumophila (strain| Philadelphia 1 / ATCC 33152 / DSM 7513) Length = 615 Score = 175 bits (444), Expect = 4e-43 Identities = 116/363 (31%), Positives = 183/363 (50%), Gaps = 34/363 (9%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 ++++ GDGIG E+ ++ ++ +VP+ D+ IP + I + Sbjct: 9 IAVLPGDGIGIEVTEATLPVFEVLDVPVILNYGDIGWEFWKKEGAAIPSRTWQLIASSDT 68 Query: 377 ALKGP------------LATPIGKG---HVSLNLTLRRTFNLFANVRPCKSIQGYKTPYD 511 L G L+ + K +VS + LR+ +LFANVRPC SI P++ Sbjct: 69 VLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSIDDQSKPFN 128 Query: 512 NVDTVLIRENTEGEYSGIEHVVVDGVVQSI-------------------KLITREASERV 634 +IREN+EG Y G ++ + + S+ +L ++ R+ Sbjct: 129 ---FCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEASCALRLQSKSGLTRL 185 Query: 635 LRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKV 814 FAF++A G P+V + K +++ S + A+ YP I+ D +D L + Sbjct: 186 FDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPKIQADILNVDAVALWL 245 Query: 815 VTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAG 994 + P + V+V N++GDILSD+ AG++GGLGL PS NIGD+ S FE VHGS P I Sbjct: 246 IKSPEKFG--VIVAENMFGDILSDVGAGVMGGLGLAPSANIGDKGSYFEPVHGSGPRIR- 302 Query: 995 KGLANPTALLLSSIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAV 1174 K ANP+A+ L+ M+L H G + A KI A+ + + E + IT DLGG + T + A AV Sbjct: 303 KNCANPSAMFLTISMLLNHFGYPDRAKKIVNAVMQVIKEKRFITYDLGGHATTTDMANAV 362 Query: 1175 IKN 1183 I++ Sbjct: 363 IEH 365
>O86504:LEU3_STRCO 3-isopropylmalate dehydrogenase - Streptomyces coelicolor| Length = 347 Score = 174 bits (440), Expect = 1e-42 Identities = 118/334 (35%), Positives = 184/334 (55%), Gaps = 17/334 (5%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA---NVPIKWESIDV-TPSLNADGKTVIPDESIASIK 364 +++I GDGIG E+ + SA +V ++ + D +A G+T + D + ++K Sbjct: 7 LAVIPGDGIGQEVVAEGLKVLSAVLPQDVKLETKEFDFGARRYHATGET-LTDADLDALK 65 Query: 365 RNYVALKGPL---ATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY---DNVDTV 526 + L G + + P G L LR F+ N+RP K + G TP +D V Sbjct: 66 AHDAILLGAIGDPSVPSGVLERGFLLKLRFAFDHHVNLRPSKLLPGVATPLAGQPEIDFV 125 Query: 527 LIRENTEGEYSGIEHVVVDG----VVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVH 694 ++RE TEG Y+G + G V + + T ERV+R AF AQ + K+ +VH Sbjct: 126 VVREGTEGPYTGNGGTIRKGTEHEVATEVSVNTAYGVERVVRDAFARAQARPRKKLTLVH 185 Query: 695 KATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGD 874 K ++ + L+ N+ ++A EYP + D +D A + +VTDP ++ V+V NL+GD Sbjct: 186 KNNVLTFAGHLWTNIFNKVAAEYPEVTTDYLHVDAATIFLVTDPARFD--VIVTDNLFGD 243 Query: 875 ILSDMCAGLIGGLGLTPSGNI---GDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMML 1045 I++D+ A + GG+G+ SGNI GD S+FE VHGSAPDIAG+G A+PTA +LS ++L Sbjct: 244 IITDLAAAVSGGIGVAASGNINPSGDFPSMFEPVHGSAPDIAGQGKADPTATVLSVALLL 303 Query: 1046 QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKS 1147 +H+G + A +I+ A+ L E GDL +S Sbjct: 304 RHLGYEDEAARIEDAVSADLGE----RGDLPARS 333
>Q6GG12:IDH_STAAR Isocitrate dehydrogenase [NADP] - Staphylococcus aureus (strain| MRSA252) Length = 422 Score = 173 bits (439), Expect = 1e-42 Identities = 128/404 (31%), Positives = 196/404 (48%), Gaps = 74/404 (18%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDVTPSLNADGKTVIPDESIA 355 + I GDGIGP+I ++ + AA I+W+ + +P E++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 356 SIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY---DNVDTV 526 +IK +A+KGPL TPIG G SLN+ LR+ +LF +RP + +G +P +VD V Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMV 140 Query: 527 LIRENTEGEYSGIE--------HVVVDGVVQ---------------SIKLITREASERVL 637 + RENTE Y+GIE V+D + IK +++E +ER++ Sbjct: 141 IFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLF----------------------------- 730 R A QYA D + V +VHK IMK ++G F Sbjct: 201 RAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFTWQQYDEIVEKE 260 Query: 731 ----LNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 N+ +E A++ I + D +++T P ++ V+ NL GD +SD A Sbjct: 261 GRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHD--VVATMNLNGDYISDALAA 318 Query: 899 LIGGLGLTPSGNIGDEC--SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHA 1072 +GG+G+ P NI E +IFEA HG+AP AG NP++++LSS++ML+H+G E A Sbjct: 319 QVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAA 378 Query: 1073 NKIQAAIFKTLAEGKTITGDL------GGKSKTHEYAAAVIKNL 1186 +KI +I T+A K +T D + T +A +IKNL Sbjct: 379 DKITDSIEDTIA-SKVVTYDFARLMDGAEEVSTSAFADELIKNL 421
>Q8NW61:IDH_STAAW Isocitrate dehydrogenase [NADP] - Staphylococcus aureus (strain MW2)| Length = 422 Score = 172 bits (437), Expect = 2e-42 Identities = 129/402 (32%), Positives = 192/402 (47%), Gaps = 72/402 (17%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDVTPSLNADGKTVIPDESIA 355 + I GDGIGP+I ++ + AA I+W+ + +P E++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 356 SIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY---DNVDTV 526 +IK +A+KGPL TPIG G SLN+ LR+ +LF +RP + +G +P +VD V Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMV 140 Query: 527 LIRENTEGEYSGIE--------HVVVDGVVQ---------------SIKLITREASERVL 637 + RENTE Y+GIE V+D + IK +++E +ER++ Sbjct: 141 IFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIA-KEYPNIEFDAELLDNACLKV 814 R A QYA D + V +VHK IMK ++G F G ++A E+ + F + D K Sbjct: 201 RAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALSEFGDQVFTWQQYDEIVEKE 260 Query: 815 VTDPT------------------------------PYNDKVLVMPNLYGDILSDMCAGLI 904 D P V+ NL GD +SD A + Sbjct: 261 GRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV 320 Query: 905 GGLGLTPSGNIGDEC--SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANK 1078 GG+G+ P NI E +IFEA HG+AP AG NP++++LSS++ML+H+G E A+K Sbjct: 321 GGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADK 380 Query: 1079 IQAAIFKTLAEGKTITGDL------GGKSKTHEYAAAVIKNL 1186 I +I T+A K +T D + T +A +IKNL Sbjct: 381 ITDSIEDTIA-SKVVTYDFARLMDGAEEVSTSAFADELIKNL 421
>Q6G8N2:IDH_STAAS Isocitrate dehydrogenase [NADP] - Staphylococcus aureus (strain| MSSA476) Length = 422 Score = 172 bits (437), Expect = 2e-42 Identities = 129/402 (32%), Positives = 192/402 (47%), Gaps = 72/402 (17%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDVTPSLNADGKTVIPDESIA 355 + I GDGIGP+I ++ + AA I+W+ + +P E++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 356 SIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY---DNVDTV 526 +IK +A+KGPL TPIG G SLN+ LR+ +LF +RP + +G +P +VD V Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMV 140 Query: 527 LIRENTEGEYSGIE--------HVVVDGVVQ---------------SIKLITREASERVL 637 + RENTE Y+GIE V+D + IK +++E +ER++ Sbjct: 141 IFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIA-KEYPNIEFDAELLDNACLKV 814 R A QYA D + V +VHK IMK ++G F G ++A E+ + F + D K Sbjct: 201 RAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALSEFGDQVFTWQQYDEIVEKE 260 Query: 815 VTDPT------------------------------PYNDKVLVMPNLYGDILSDMCAGLI 904 D P V+ NL GD +SD A + Sbjct: 261 GRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV 320 Query: 905 GGLGLTPSGNIGDEC--SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANK 1078 GG+G+ P NI E +IFEA HG+AP AG NP++++LSS++ML+H+G E A+K Sbjct: 321 GGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADK 380 Query: 1079 IQAAIFKTLAEGKTITGDL------GGKSKTHEYAAAVIKNL 1186 I +I T+A K +T D + T +A +IKNL Sbjct: 381 ITDSIEDTIA-SKVVTYDFARLMDGAEEVSTSAFADELIKNL 421
>P99167:IDH_STAAN Isocitrate dehydrogenase [NADP] - Staphylococcus aureus (strain N315)| Length = 422 Score = 172 bits (437), Expect = 2e-42 Identities = 128/404 (31%), Positives = 195/404 (48%), Gaps = 74/404 (18%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDVTPSLNADGKTVIPDESIA 355 + I GDGIGP+I ++ + AA I+W+ + +P E++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 356 SIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY---DNVDTV 526 +IK +A+KGPL TPIG G SLN+ LR+ +LF +RP + +G +P +VD V Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMV 140 Query: 527 LIRENTEGEYSGIE--------HVVVDGVVQ---------------SIKLITREASERVL 637 + RENTE Y+GIE V+D + IK +++E +ER++ Sbjct: 141 IFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLF----------------------------- 730 R A QYA D + V +VHK IMK ++G F Sbjct: 201 RAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALSEFGDQVFTWQQYDEIVENE 260 Query: 731 ----LNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 N +E A++ I + D +++T P ++ V+ NL GD +SD A Sbjct: 261 GRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHD--VVATMNLNGDYISDALAA 318 Query: 899 LIGGLGLTPSGNIGDEC--SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHA 1072 +GG+G+ P NI E +IFEA HG+AP AG NP++++LSS++ML+H+G E A Sbjct: 319 QVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAA 378 Query: 1073 NKIQAAIFKTLAEGKTITGDL------GGKSKTHEYAAAVIKNL 1186 +KI +I T+A K +T D + T +A +IKNL Sbjct: 379 DKITDSIEDTIA-SKVVTYDFARLMDGAEEVSTSAFADELIKNL 421
>P65099:IDH_STAAM Isocitrate dehydrogenase [NADP] - Staphylococcus aureus (strain Mu50| / ATCC 700699) Length = 422 Score = 172 bits (437), Expect = 2e-42 Identities = 128/404 (31%), Positives = 195/404 (48%), Gaps = 74/404 (18%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDVTPSLNADGKTVIPDESIA 355 + I GDGIGP+I ++ + AA I+W+ + +P E++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 356 SIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY---DNVDTV 526 +IK +A+KGPL TPIG G SLN+ LR+ +LF +RP + +G +P +VD V Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMV 140 Query: 527 LIRENTEGEYSGIE--------HVVVDGVVQ---------------SIKLITREASERVL 637 + RENTE Y+GIE V+D + IK +++E +ER++ Sbjct: 141 IFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLF----------------------------- 730 R A QYA D + V +VHK IMK ++G F Sbjct: 201 RAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALSEFGDQVFTWQQYDEIVENE 260 Query: 731 ----LNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 N +E A++ I + D +++T P ++ V+ NL GD +SD A Sbjct: 261 GRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHD--VVATMNLNGDYISDALAA 318 Query: 899 LIGGLGLTPSGNIGDEC--SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHA 1072 +GG+G+ P NI E +IFEA HG+AP AG NP++++LSS++ML+H+G E A Sbjct: 319 QVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAA 378 Query: 1073 NKIQAAIFKTLAEGKTITGDL------GGKSKTHEYAAAVIKNL 1186 +KI +I T+A K +T D + T +A +IKNL Sbjct: 379 DKITDSIEDTIA-SKVVTYDFARLMDGAEEVSTSAFADELIKNL 421
>Q5HF79:IDH_STAAC Isocitrate dehydrogenase [NADP] - Staphylococcus aureus (strain COL)| Length = 422 Score = 172 bits (437), Expect = 2e-42 Identities = 128/404 (31%), Positives = 195/404 (48%), Gaps = 74/404 (18%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDVTPSLNADGKTVIPDESIA 355 + I GDGIGP+I ++ + AA I+W+ + +P E++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 356 SIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY---DNVDTV 526 +IK +A+KGPL TPIG G SLN+ LR+ +LF +RP + +G +P +VD V Sbjct: 81 TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMV 140 Query: 527 LIRENTEGEYSGIE--------HVVVDGVVQ---------------SIKLITREASERVL 637 + RENTE Y+GIE V+D + IK +++E +ER++ Sbjct: 141 IFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLV 200 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLF----------------------------- 730 R A QYA D + V +VHK IMK ++G F Sbjct: 201 RAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALSEFGDQVFTWQQYDEIVENE 260 Query: 731 ----LNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 N +E A++ I + D +++T P ++ V+ NL GD +SD A Sbjct: 261 GRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHD--VVATMNLNGDYISDALAA 318 Query: 899 LIGGLGLTPSGNIGDEC--SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHA 1072 +GG+G+ P NI E +IFEA HG+AP AG NP++++LSS++ML+H+G E A Sbjct: 319 QVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAA 378 Query: 1073 NKIQAAIFKTLAEGKTITGDL------GGKSKTHEYAAAVIKNL 1186 +KI +I T+A K +T D + T +A +IKNL Sbjct: 379 DKITDSIEDTIA-SKVVTYDFARLMDGAEEVSTSAFADELIKNL 421
>P39126:IDH_BACSU Isocitrate dehydrogenase [NADP] - Bacillus subtilis| Length = 423 Score = 172 bits (437), Expect = 2e-42 Identities = 124/404 (30%), Positives = 193/404 (47%), Gaps = 74/404 (18%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDVTPSLNADGKTVIPDESIA 355 + IEGDG GP+I + + AA I W+ + +P E++ Sbjct: 22 IPFIEGDGTGPDIWNAASKVLEAAVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLD 81 Query: 356 SIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY---DNVDTV 526 I+ ++A+KGPL TP+G G SLN+ LR+ +LF +RP + G +P ++ D V Sbjct: 82 VIREYFIAIKGPLTTPVGGGIRSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMV 141 Query: 527 LIRENTEGEYSGIEHVVVDGVVQ-----------------------SIKLITREASERVL 637 + RENTE Y+GIE+ VQ IK ++ E + R++ Sbjct: 142 IFRENTEDIYAGIEYAKGSEEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLV 201 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIA-KEYPNIEF------------ 778 R A YA + G+ V +VHK IMK ++G F N G E+A KEY + F Sbjct: 202 RAAIDYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQ 261 Query: 779 ----------DAELLDNACLK----------VVTDPTPYNDKVLVMPNLYGDILSDMCAG 898 +AE +K ++T P ++ V+ NL GD +SD A Sbjct: 262 GKDAANKAQSEAEAAGKIIIKDSIADIFLQQILTRPNEFD--VVATMNLNGDYISDALAA 319 Query: 899 LIGGLGLTPSGNIGDEC--SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHA 1072 +GG+G+ P NI E +IFEA HG+AP AG NP++++LS +++L+H+G E A Sbjct: 320 QVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAA 379 Query: 1073 NKIQAAIFKTLAEGKTITGDL------GGKSKTHEYAAAVIKNL 1186 + + ++ KT+A K +T D + K E+ +IKN+ Sbjct: 380 DLVIKSMEKTIA-SKVVTYDFARLMDGATEVKCSEFGEELIKNM 422
>Q59985:IDH_STRSL Isocitrate dehydrogenase [NADP] - Streptococcus salivarius| Length = 391 Score = 172 bits (436), Expect = 3e-42 Identities = 121/384 (31%), Positives = 193/384 (50%), Gaps = 42/384 (10%) Frame = +2 Query: 143 SSQVAAFQGQKGSDGKYTVSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDV 301 + ++ GQ + + IEGDG+G +I ++ + I+ A I+W+ + Sbjct: 2 AEKIVMKNGQLQVSDRPIIPFIEGDGVGHDIWKNAQAIFDKAVEVAYEGKRHIEWQELLA 61 Query: 302 TPSLNADGKTVIPDESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCK 481 +P E++ +I+ + VA+KGPL TP+G G SLN+ LR+ +L+A VRP + Sbjct: 62 GKKAYDKTGEWLPKETLEAIRESLVAIKGPLETPVGGGIRSLNVALRQELDLYACVRPVR 121 Query: 482 SIQGYKTPY---DNVDTVLIRENTEGEYSGIEHVV----VDGVVQ--------------- 595 G +P + + + RENTE Y+GIE V V++ Sbjct: 122 YFDGVASPLKEPEKTNITIFRENTEDIYAGIEWEAGTADVKRVIEFLQTEMNVNKIRFPE 181 Query: 596 ----SIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKE- 760 IK I+ E S+R++R A YA KV +VHK I K ++G F G E+A+E Sbjct: 182 SSSIGIKPISIEGSKRLIRSAIDYALKNNLKKVTLVHKGNIQKFTEGGFRKWGYEVAQED 241 Query: 761 ------YPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLT 922 +E + + DN +++ +P ++ V+ + NL GD SD A +GG+G++ Sbjct: 242 YKEELLAGRLEINDIIADNFLQQILLNPEKFD--VVALTNLNGDYASDALAAQVGGIGIS 299 Query: 923 PSGNIGDEC--SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIF 1096 P NI + +IFEA HG+APDIA + ANP ++LLS M+L ++G E A I +AI Sbjct: 300 PGANINYQTGHAIFEATHGTAPDIADQDKANPCSVLLSGCMLLDYIGWTEAAQLITSAIE 359 Query: 1097 KTLAEGKTITGDLGGKSKTHEYAA 1168 KT + T DL + + +A Sbjct: 360 KTF-KADIFTADLAFGKQAYSTSA 382
>Q9ZN36:IDH_HELPJ Isocitrate dehydrogenase [NADP] - Helicobacter pylori J99| (Campylobacter pylori J99) Length = 425 Score = 172 bits (435), Expect = 4e-42 Identities = 129/400 (32%), Positives = 198/400 (49%), Gaps = 70/400 (17%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDVTPSLNA---DGKTVIPDE 346 + IEGDGIG +I ++ + +A I W + V D K + P+E Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEE 91 Query: 347 ------SIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCK---SIQGYK 499 +I +I V++KGPL TPIG+G SLN+ LR+ +L+ +RP + S K Sbjct: 92 QWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVK 151 Query: 500 TPYDNVDTVLIRENTEGEYSGIE------------HVVVDGVV-----------QSIKLI 610 P VD V+ REN+E Y+GIE H + + + IK I Sbjct: 152 EP-QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRFPESSGVGIKPI 210 Query: 611 TREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAEL 790 ++E +ER++R A +YA D KP V VHK IMK ++G F+ G +A++ EF+A++ Sbjct: 211 SKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQK----EFNAQV 266 Query: 791 LDNACLKVVTDP----------------------TPYNDKVLVMPNLYGDILSDMCAGLI 904 +D + +P P V+ NL GD +SD A ++ Sbjct: 267 IDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAAMV 326 Query: 905 GGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQ 1084 GG+G+ P N+ D +FEA HG+AP AG NP +++LS+ MML+HMG E A+ I Sbjct: 327 GGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMGWVEAADLIV 386 Query: 1085 AAIFKTLAEGKTITGDL-----GGKS-KTHEYAAAVIKNL 1186 +A+ K + + K +T D G K K E+A+ +I+N+ Sbjct: 387 SAMEKAI-KSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
>P56063:IDH_HELPY Isocitrate dehydrogenase [NADP] - Helicobacter pylori (Campylobacter| pylori) Length = 425 Score = 171 bits (434), Expect = 5e-42 Identities = 127/401 (31%), Positives = 200/401 (49%), Gaps = 71/401 (17%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESIDVTPS----------LNADG 325 + IEGDGIG +I ++ + +A I W + V L+ + Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDYKELSPEE 91 Query: 326 KTVIPDESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCK---SIQGY 496 + ++PD +I +I V++KGPL TPIG+G SLN+ LR+ +L+ +RP + S Sbjct: 92 QWLLPD-TIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPV 150 Query: 497 KTPYDNVDTVLIRENTEGEYSGIE------------HVVVDGVVQ-----------SIKL 607 K P VD V+ REN+E Y+GIE H + + + +K Sbjct: 151 KEP-QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESSGIGVKP 209 Query: 608 ITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAE 787 I++E +ER++R A +YA D KP V VHK IMK ++G F+ G +A++ EF+A+ Sbjct: 210 ISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQK----EFNAQ 265 Query: 788 LLDNACLKVVTDP----------------------TPYNDKVLVMPNLYGDILSDMCAGL 901 ++D + +P P V+ NL GD +SD A + Sbjct: 266 VIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAAM 325 Query: 902 IGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKI 1081 +GG+G+ P N+ D +FEA HG+AP AG NP +++LS+ MML+HMG E A+ I Sbjct: 326 VGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMGWVEAADLI 385 Query: 1082 QAAIFKTLAEGKTITGDL-----GGKS-KTHEYAAAVIKNL 1186 +A+ K + + K +T D G K K E+A+ +I+N+ Sbjct: 386 VSAMEKAI-KSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
>Q8G500:LEU3_BIFLO 3-isopropylmalate dehydrogenase - Bifidobacterium longum| Length = 343 Score = 170 bits (431), Expect = 1e-41 Identities = 110/328 (33%), Positives = 180/328 (54%), Gaps = 17/328 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI---AQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASI 361 Y +++I GDGIG E+ AQ + + ++E+ D+ ++P++ I Sbjct: 5 YKIAVIPGDGIGKEVTPWAQKALEKAAEGVADFEYENFDLGAERYLRDGAILPEDEEERI 64 Query: 362 KRNYVALKGPLATP-IGKGHVSLNLTLRRTFNL--FANVRPCKSIQGYKTPYDN---VDT 523 K N L G + P I G + L L+ F+L + N+RP K +G +P N +D Sbjct: 65 KANDAILLGAVGDPRIKAGILERGLLLKLRFDLDQYVNLRPSKLYKGVTSPLANPGDIDF 124 Query: 524 VLIRENTEGEYSG----IEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVV 691 V++RE TEG Y G + V + + T ERV+R+AF+ A K V +V Sbjct: 125 VVVREGTEGLYCGAGGAVRRNTPQEVATEVSINTAYGVERVVRYAFKLAMK-RKKHVTLV 183 Query: 692 HKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYG 871 HK ++ + ++ + ++ +EYP + D + +D A + +V+DP+ ++ V++ NL+G Sbjct: 184 HKKNVLVNAGDMWQRIVDKVGEEYPEVTHDYQHIDAATIFLVSDPSRFD--VILTDNLFG 241 Query: 872 DILSDMCAGLIGGLGLTPSG--NIGDEC-SIFEAVHGSAPDIAGKGLANPTALLLSSIMM 1042 DIL+D ++GG+G + SG N DE S+FE +HGSAPDIAG+ ANPTA +LS+ M+ Sbjct: 242 DILTDEAGSVVGGVGYSASGCINASDEFPSMFEPIHGSAPDIAGQNKANPTAAILSAAML 301 Query: 1043 LQHMGLFEHANKIQAAIFKTLAE-GKTI 1123 L+H+G + A KI A+ + E G T+ Sbjct: 302 LEHLGFDDAAKKIHTAVEADIEELGSTV 329
>Q2J6V8:LEU3_FRASC 3-isopropylmalate dehydrogenase - Frankia sp. (strain CcI3)| Length = 342 Score = 169 bits (429), Expect = 2e-41 Identities = 108/318 (33%), Positives = 172/318 (54%), Gaps = 13/318 (4%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 +++I GDGIGPE+ + A + + D+ + +PD + ++ + Sbjct: 3 LAVIGGDGIGPEVVAEGLRVLRAVHPKVDTTEYDLGARRWHETGETLPDSVLEELRGHDA 62 Query: 377 ALKGPLA---TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDN---VDTVLIRE 538 L G + P G L L LR F+ N+RP + G ++P +D +++RE Sbjct: 63 ILLGAVGDPGVPSGVLERGLLLRLRFEFDHHVNLRPVRLYPGVRSPLAGDPAIDMIVVRE 122 Query: 539 NTEGEYSGIEHVVVDGVVQSI----KLITREASERVLRFAFQYAQDIGKPKVRVVHKATI 706 TEG Y+G V+ G + L TR ERV+R AF+ A + + +VHK + Sbjct: 123 GTEGPYAGAGGVLRKGTPHEVATEESLNTRYGVERVVRDAFRRADRRERRHLTLVHKNNV 182 Query: 707 MKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSD 886 + + L+ E+A E+P++ D + +D A + VTDP ++ V+V N++GDIL+D Sbjct: 183 LTKAGDLWSRTVAEVAPEFPDVRVDYQHVDAASMFFVTDPGRFD--VVVTDNMFGDILTD 240 Query: 887 MCAGLIGGLGLTPSGNI---GDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMG 1057 + A + GG+GL SGN+ G S+FE VHGSAPDIAG+ LA+PTA + S M+L H+G Sbjct: 241 IGAAITGGIGLAASGNLDPSGVHPSMFEPVHGSAPDIAGRQLADPTATVASVAMLLDHLG 300 Query: 1058 LFEHANKIQAAIFKTLAE 1111 E A K++AA+ +LA+ Sbjct: 301 HAEEAAKVEAAVASSLAD 318
>Q02143:LEU3_LACLA 3-isopropylmalate dehydrogenase - Lactococcus lactis subsp. lactis| (Streptococcus lactis) Length = 345 Score = 169 bits (428), Expect = 3e-41 Identities = 116/348 (33%), Positives = 188/348 (54%), Gaps = 22/348 (6%) Frame = +2 Query: 206 IEGDGIGPEIAQSVKDIYSAANVPIKWE-SIDVTP----SLNADGKTVIPDESIASIKRN 370 + GDGIGPEI + + A + I +E ++ +++ G +P+E++ ++K Sbjct: 8 LAGDGIGPEIMSAGLSVLKAVSKKIDFEYELEAKDFGGIAIDKHGHP-LPEETLQAVKNA 66 Query: 371 YVALKGPLATPIGKGHVSLN----------LTLRRTFNLFANVRPCKSIQGYKT-----P 505 L + GH N L LR+ L+ANVRP K K Sbjct: 67 DAILLAAI------GHPKYNNAKVRPEQGLLALRKELGLYANVRPLKIYPALKKLSPIRN 120 Query: 506 YDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVR 685 +NVD ++IRE T G Y G +H + D + + + + R+L FAF+ AQ + + Sbjct: 121 VENVDFLVIRELTGGIYFG-QHELADDKARDVNDYSADEIRRILHFAFKSAQSRPRKLLT 179 Query: 686 VVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNL 865 V K ++ S L+ + EIA EYP++ + +L+D+ + ++T+P ++ V+V NL Sbjct: 180 SVDKQNVLATSK-LWRKMADEIADEYPDVRLEHQLVDSCAMLLITNPQQFD--VIVTENL 236 Query: 866 YGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSSIMM 1042 +GDILSD + L G LG+ PS + G + +++E +HGSAPDIAGKG+ANP +++LS MM Sbjct: 237 FGDILSDEASSLAGSLGVMPSSSHGFNGLALYEPIHGSAPDIAGKGIANPVSMILSIAMM 296 Query: 1043 L-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKN 1183 L + G + A I+ A+ +T +G +T DLGG + T E A++KN Sbjct: 297 LRESFGQEDGAAMIEKAVTQTFTDG-ILTKDLGGTATTKEMTEAILKN 343
>P96318:IDH_CALNO Isocitrate dehydrogenase [NADP] - Caldococcus noboribetus| Length = 429 Score = 169 bits (427), Expect = 3e-41 Identities = 124/385 (32%), Positives = 191/385 (49%), Gaps = 53/385 (13%) Frame = +2 Query: 140 ASSQVAAFQ-GQKGSDGKYTVSLIEGDGIGPEIAQSVKDIYSAA-------NVPIKWESI 295 + Q+A F+ G+ V+ +GDGIGPEI +S K + AA I W + Sbjct: 15 SEGQLARFENGKLIVPDNLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRRIVWWEV 74 Query: 296 DVTPSLNADGKTVIPDESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRP 475 + +++PD ++ + K V LKGPL TP+G G SLN+TLR +L++NVRP Sbjct: 75 TAGEEAQKECGSLLPDGTLQAFKLARVNLKGPLTTPVGGGFRSLNVTLRMVLDLYSNVRP 134 Query: 476 CKSIQGYKTPY---DNVDTVLIRENTEGEYSGIEHVVVDGVVQSI--------------- 601 K G TP+ +N+D V+ RENTE Y+GIE Q I Sbjct: 135 VKWY-GQPTPHCHPENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKEFGIELTPD 193 Query: 602 -----KLITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGRE------ 748 K I++ ++R +R A ++A G V ++HK IMK ++G F + Sbjct: 194 TGIGIKPISKWRTQRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEF 253 Query: 749 ----IAKEYPNIEFDAE-----------LLDNACLKVVTDPTPYNDKVLVMPNLYGDILS 883 + +E N ++ + + DN +++T P YN V+V PNL GD +S Sbjct: 254 RDYVVTEEEVNTKYGGKAPEGKIIVNDRIADNMLQQIITRPGEYN--VIVTPNLNGDYIS 311 Query: 884 DMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMML-QHMGL 1060 D L+GG+G+ ++GD ++ E VHGSAP AGK + NPTA +LS + +L +G Sbjct: 312 DEANALVGGIGMAAGLDMGDGIAVAEPVHGSAPKYAGKNVINPTAEILSGMYLLSDFVGW 371 Query: 1061 FEHANKIQAAIFKTLAEGKTITGDL 1135 E ++ A+ + +A K +T DL Sbjct: 372 PEVKLLVEYAVKQAIAH-KQVTYDL 395
>Q5YRX2:LEU3_NOCFA 3-isopropylmalate dehydrogenase - Nocardia farcinica| Length = 335 Score = 167 bits (424), Expect = 7e-41 Identities = 110/331 (33%), Positives = 174/331 (52%), Gaps = 15/331 (4%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 +++I GDGIGPE+ + ++ D+ ++PD + ++ + Sbjct: 3 LAVIPGDGIGPEVIAEALKVLDVVVPGVEKTEYDLGAKRYHATGEILPDSVLPELREHDA 62 Query: 377 ALKGPLATP-IGKGHVSLNLTLRRTFNL--FANVRPCKSIQGYKTPY---DNVDTVLIRE 538 L G + P + G + L LR F L N+RP + G ++P ++D V++RE Sbjct: 63 ILLGAIGDPSVPSGVLERGLLLRTRFELDHHVNLRPSRLFTGVRSPLAGAPDIDFVVVRE 122 Query: 539 NTEGEYSGIEHVV----VDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATI 706 TEG Y+G + V + TR ERV+R+AF AQ K + +VHK + Sbjct: 123 GTEGPYTGTGGAIRVRTPHEVATEVSTNTRFGIERVVRYAFAKAQARRK-HLTLVHKTNV 181 Query: 707 MKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSD 886 + + L+ E+ E+P + + +D A + +VTDP ++ V+V NL+GDI++D Sbjct: 182 LTFAGSLWQRTVDEVGAEFPEVTVAYQHIDAATIHMVTDPGRFD--VIVTDNLFGDIITD 239 Query: 887 MCAGLIGGLGLTPSGNI---GDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMG 1057 + A + GG+GL SGNI G S+FE VHGSAPDIAG+ A+PTA +LS ++L H+G Sbjct: 240 LAAAVSGGIGLAASGNIDASGTNPSMFEPVHGSAPDIAGQSKADPTAAILSVSLLLNHLG 299 Query: 1058 LFEHANKIQAAIFKTLA--EGKTITGDLGGK 1144 E A +I AA+ K LA G T ++G + Sbjct: 300 DTEAAARIDAAVAKDLAARSGTASTVEIGDR 330
>Q4JUQ0:LEU3_CORJK 3-isopropylmalate dehydrogenase - Corynebacterium jeikeium (strain| K411) Length = 338 Score = 167 bits (422), Expect = 1e-40 Identities = 119/344 (34%), Positives = 176/344 (51%), Gaps = 14/344 (4%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 +++I GDGIG E+ + A ++ D+ ++ DE + S++ + Sbjct: 3 LAVIAGDGIGTEVTAEALKVLHALRDDVETTDYDLGARRYLRNGELLTDEDLDSLREHDA 62 Query: 377 ALKG----PLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDN---VDTVLIR 535 L G P P G L L LR + N+RP K G +P N +D V++R Sbjct: 63 ILLGAIGDPRTVPAGVLERGLLLPLRFKLDHAVNLRPSKLYPGSSSPLANPGDIDFVVVR 122 Query: 536 ENTEGEYSGIEHVVVDG----VVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKAT 703 E TEG Y G + G V + T ERV+R AF+ AQ K K+ VHK Sbjct: 123 EGTEGLYCGNGGTLRAGTDYEVASEVSQNTYYGVERVVRDAFERAQSRRK-KLTWVHKTN 181 Query: 704 IMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILS 883 ++ + L+ + +EYP ++ D +D A + +VT P Y+ V+V NL+GDIL+ Sbjct: 182 VLVNAGSLWQRAIETVGQEYPEVQVDYNHIDAATIYMVTKPQEYD--VIVTDNLFGDILT 239 Query: 884 DMCAGLIGGLGLTPSGNIGDEC---SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHM 1054 D+ + GG+GL SGNI S+FE VHGSAPDIAG+G+A+P A +LS +ML+H+ Sbjct: 240 DLAGAVTGGIGLAASGNIDPSRKNPSMFEPVHGSAPDIAGQGIADPCAAILSVALMLRHL 299 Query: 1055 GLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 G +A +I+AA+ LAE + GG KT E V+ NL Sbjct: 300 GDDANAERIEAAV---LAEAGSRD---GGPVKTAEVGDRVVANL 337
>P70792:TTUC4_AGRVI Probable tartrate dehydrogenase/decarboxylase ttuC' - Agrobacterium| vitis (Rhizobium vitis) Length = 358 Score = 166 bits (421), Expect = 2e-40 Identities = 106/349 (30%), Positives = 181/349 (51%), Gaps = 20/349 (5%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSA-----ANVPIKWESIDVTPSLNADGKTVIPDESI 352 +Y ++ I DGIGPE+ + + A + I E+ D ++P + + Sbjct: 3 EYKIAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDWGSDYYKKNGVMMPADGL 62 Query: 353 ASIKRNYVALKGPLATPIGKGHVSL---NLTLRRTFNLFANVRPCKSIQGYKTPYDN--- 514 +K+ G + P H++L L + + F+ +ANVRP K + G P N Sbjct: 63 EQLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLRNCGP 122 Query: 515 --VDTVLIRENTEGEYSG----IEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 +D V++REN+EGEYSG + + V + + TR R++R+AF+ AQ + Sbjct: 123 GDLDWVIVRENSEGEYSGHGGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRK 182 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 + VV K+ + ++ + E++KE+P++ +D L+D +++ P + +V Sbjct: 183 LLTVVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQSLD--TIVA 240 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIGDEC---SIFEAVHGSAPDIAGKGLANPTALLL 1027 NL+ DILSD+ L G LG+ P+ NI E S+FE +HGSA DI GKG+ANP A Sbjct: 241 TNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVATFW 300 Query: 1028 SSIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAV 1174 ++ ML+H+G + A ++ +A+ + + E +T D+GG + T + AV Sbjct: 301 TAAQMLEHLGEKDAATRLMSAV-ERVTEAGILTPDVGGTANTQQVTDAV 348
>P05645:LEU3_BACSU 3-isopropylmalate dehydrogenase - Bacillus subtilis| Length = 365 Score = 166 bits (421), Expect = 2e-40 Identities = 122/363 (33%), Positives = 199/363 (54%), Gaps = 24/363 (6%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIA 355 K ++L+ GDGIGPE+ +S D+ + N ++E + + + +P+E++A Sbjct: 2 KKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIGGAAIDEHHNPLPEETVA 61 Query: 356 SIKRNYVALKGPLATPIGKGHVSLN------LTLRRTFNLFANVRPCKSIQGY------- 496 + K L G + P ++S L++R+ +LFAN+RP K + Sbjct: 62 ACKNADAILLGAVGGPKWDQNLSELRPEKGLLSIRKQLDLFANLRPVKVFESLSDRSPLK 121 Query: 497 KTPYDNVDTVLIRENTEGEYSGI---EHVVVDGVVQSIKLI--TREASERVLRFAFQYAQ 661 K DNVD V++RE T G Y G +V +G +++ + R ERV+R F+ A Sbjct: 122 KEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVDTLFYKRTEIERVIREGFKMAA 181 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 K KV V KA +++ S L+ + ++A+E+P+++ + L+DNA ++++ P ++ Sbjct: 182 -ARKGKVTSVDKANVLE-SSRLWREVAEDVAQEFPDVKLEHMLVDNAAMQLIYAPNQFD- 238 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTA 1018 V+V N++GDILSD + L G LG+ PS ++ +FE VHGSAPDIAGKG+ANP A Sbjct: 239 -VVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHLFEPVHGSAPDIAGKGMANPFA 297 Query: 1019 LLLSSIMMLQ-HMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL*IA 1195 +LS+ M+L+ GL E A ++ A+ K LA GK T DL +S+ A+ + + A Sbjct: 298 AILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKR-TRDL-ARSEEFSSTQAITEEVKAA 355 Query: 1196 IPS 1204 I S Sbjct: 356 IMS 358
>P70787:TTUC2_AGRVI Probable tartrate dehydrogenase/decarboxylase ttuC - Agrobacterium| vitis (Rhizobium vitis) Length = 364 Score = 166 bits (420), Expect = 2e-40 Identities = 106/349 (30%), Positives = 181/349 (51%), Gaps = 20/349 (5%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSA-----ANVPIKWESIDVTPSLNADGKTVIPDESI 352 +Y ++ I DGIGPE+ + + A + I E+ D ++P + + Sbjct: 3 EYKIAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDWGSDYYKKNGVMMPADGL 62 Query: 353 ASIKRNYVALKGPLATPIGKGHVSL---NLTLRRTFNLFANVRPCKSIQGYKTPYDN--- 514 +K+ G + P H++L L + + F+ +ANVRP K + G P N Sbjct: 63 EQLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLRNCGP 122 Query: 515 --VDTVLIRENTEGEYSG----IEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 +D V++REN+EGEYSG + + V + + TR R++R+AF+ AQ + Sbjct: 123 GDLDWVIVRENSEGEYSGHGGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRK 182 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 + VV K+ + ++ + E++KE+P++ +D L+D +++ P + +V Sbjct: 183 LLTVVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQSLD--TIVA 240 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIGDEC---SIFEAVHGSAPDIAGKGLANPTALLL 1027 NL+ DILSD+ L G LG+ P+ NI E S+FE +HGSA DI GKG+ANP A Sbjct: 241 TNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVATFW 300 Query: 1028 SSIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAV 1174 ++ ML+H+G + A ++ +A+ + + E +T D+GG + T + AV Sbjct: 301 TAAQMLEHLGEKDAATRLMSAV-ERVTEAGILTPDVGGTADTQQVTDAV 348
>P94929:LEU3_MYCBO 3-isopropylmalate dehydrogenase - Mycobacterium bovis| Length = 336 Score = 166 bits (419), Expect = 3e-40 Identities = 109/331 (32%), Positives = 180/331 (54%), Gaps = 17/331 (5%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDV-TPSLNADGKTVIPDESIASIKRNY 373 +++I GDGIGPE+ + A ++ S D+ +A G+ V+PD +A ++ + Sbjct: 3 LAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGE-VLPDSVVAELRNHD 61 Query: 374 VALKGPLATP-IGKGHVSLNLTLRRTFNL--FANVRPCKSIQGYKTPYDN---VDTVLIR 535 L G + P + G + L LR F L N+RP + G +P +D V++R Sbjct: 62 AILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVR 121 Query: 536 ENTEGEYSGIEHVVVDG----VVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKAT 703 E TEG Y+G + G V + + T RV+ AF+ A+ K + +VHK Sbjct: 122 EGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVADAFERARRRRK-HLTLVHKTN 180 Query: 704 IMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILS 883 ++ ++ GL+L E+ + YP++E + +D A + ++TDP ++ V+V NL+GDI++ Sbjct: 181 VLTLAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFD--VIVTDNLFGDIIT 238 Query: 884 DMCAGLIGGLGLTPSGNIGD---ECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHM 1054 D+ A + GG+GL SGNI S+FE VHGSAPDIAG+G+A+PTA ++S ++L H+ Sbjct: 239 DLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHL 298 Query: 1055 GLFEHANKIQAAI---FKTLAEGKTITGDLG 1138 G + A ++ A+ T + T D+G Sbjct: 299 GEHDAAARVDRAVEAHLATRGSERLATSDVG 329
>P61495:LEU3_THETH 3-isopropylmalate dehydrogenase - Thermus thermophilus| Length = 345 Score = 165 bits (418), Expect = 4e-40 Identities = 117/349 (33%), Positives = 194/349 (55%), Gaps = 19/349 (5%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQS----VKDIYSAANVPIKWESIDVT-PSLNADGKTVIPDESIASI 361 V+++ GDGIGPE+ ++ ++ + A + + +E +++A G+ P+ + + Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEP-FPEPTRKGV 61 Query: 362 KRNYVALKGPLATPIGKG---HVSLN---LTLRRTFNLFANVRPCKSIQGYK--TPYDN- 514 + L G + P G +S L+LR++ +LFAN+RP K G + +P Sbjct: 62 EEAEAVLLGSVGGPKWDGLPRKISPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEE 121 Query: 515 ----VDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKV 682 VD +++RE T G Y G + + + + ++ ERV R AF+ A+ K V Sbjct: 122 IARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVV 181 Query: 683 RVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPN 862 V KA ++++ + + E+ + YP++ + + +D A + +V P ++ V+V N Sbjct: 182 SV-DKANVLEVGE-FWRKTVEEVGRGYPDVALEHQYVDAAAMHLVRSPARFD--VVVTGN 237 Query: 863 LYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMM 1042 ++GDILSD+ + L G LGL PS ++G +FE VHGSAPDIAGKG+ANPTA +LS+ MM Sbjct: 238 IFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMM 297 Query: 1043 LQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 L+H GL E A K++ A+ K L E T DLGG + T + A V+++L Sbjct: 298 LEHAFGLVELARKVEDAVAKALLE--TPPPDLGGSAGTEAFTATVLRHL 344
>Q82JN6:LEU3_STRAW 3-isopropylmalate dehydrogenase - Streptomyces avermitilis| Length = 347 Score = 165 bits (417), Expect = 5e-40 Identities = 110/322 (34%), Positives = 183/322 (56%), Gaps = 17/322 (5%) Frame = +2 Query: 197 VSLIEGDGIGPEI-AQSVKDIYSAANVPIKWESIDV---TPSLNADGKTVIPDESIASIK 364 +++I GDGIG E+ AQ +K + +A +K E+ + +A G+T + D + ++K Sbjct: 7 LAVIPGDGIGQEVVAQGLKVLSAALPSDVKLETKEFDFGARRYHATGET-LTDADLDALK 65 Query: 365 RNYVALKGPL---ATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY---DNVDTV 526 ++ L G + + P G L LR F+ N+RP K + G +TP +D V Sbjct: 66 QHDAILLGAIGDPSVPSGVLERGFLLKLRFAFDHHVNLRPSKLLPGVETPLAGQPEIDFV 125 Query: 527 LIRENTEGEYSGIEHVVVDG----VVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVH 694 ++RE TEG Y+G + G V + L T ERV+R A+ AQ + K+ +VH Sbjct: 126 VVREGTEGPYTGNGGTIRTGTPHAVATEVSLNTAFGIERVVRDAYARAQARPRKKLALVH 185 Query: 695 KATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGD 874 K ++ + L+ ++ ++ +E+P++ + +D A + +VT P ++ V+V NL+GD Sbjct: 186 KNNVLVHAGHLWTDIFNKVGEEFPDVTTEYMHVDAATIYLVTQPERFD--VIVTDNLFGD 243 Query: 875 ILSDMCAGLIGGLGLTPSGNI---GDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMML 1045 I++D+ A + GG+G+ SGNI G S+FE VHGSAPDIAG+G A+P+A +LS ++L Sbjct: 244 IITDLAAAISGGIGVAASGNINPSGAYPSMFEPVHGSAPDIAGQGKADPSATILSVALLL 303 Query: 1046 QHMGLFEHANKIQAAIFKTLAE 1111 +H+G A +I+ A+ LAE Sbjct: 304 RHLGYEAEAARIEEAVSADLAE 325
>P95313:LEU3_MYCTU 3-isopropylmalate dehydrogenase - Mycobacterium tuberculosis| Length = 336 Score = 165 bits (417), Expect = 5e-40 Identities = 109/331 (32%), Positives = 179/331 (54%), Gaps = 17/331 (5%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDV-TPSLNADGKTVIPDESIASIKRNY 373 +++I GDGIGPE+ + A ++ S D+ +A G+ V+PD +A ++ + Sbjct: 3 LAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGE-VLPDSVVAELRNHD 61 Query: 374 VALKGPLATP-IGKGHVSLNLTLRRTFNL--FANVRPCKSIQGYKTPYDN---VDTVLIR 535 L G + P + G + L LR F L N+RP + G +P +D V++R Sbjct: 62 AILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVR 121 Query: 536 ENTEGEYSGIEHVVVDG----VVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKAT 703 E TEG Y+G + G V + + T RV+ AF+ A+ K + +VHK Sbjct: 122 EGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVADAFERARRRRK-HLTLVHKTN 180 Query: 704 IMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILS 883 ++ + GL+L E+ + YP++E + +D A + ++TDP ++ V+V NL+GDI++ Sbjct: 181 VLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFD--VIVTDNLFGDIIT 238 Query: 884 DMCAGLIGGLGLTPSGNIGD---ECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHM 1054 D+ A + GG+GL SGNI S+FE VHGSAPDIAG+G+A+PTA ++S ++L H+ Sbjct: 239 DLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHL 298 Query: 1055 GLFEHANKIQAAI---FKTLAEGKTITGDLG 1138 G + A ++ A+ T + T D+G Sbjct: 299 GEHDAAARVDRAVEAHLATRGSERLATSDVG 329
>Q44471:TTUC1_AGRVI Probable tartrate dehydrogenase/decarboxylase ttuC - Agrobacterium| vitis (Rhizobium vitis) Length = 364 Score = 164 bits (414), Expect = 1e-39 Identities = 106/349 (30%), Positives = 180/349 (51%), Gaps = 20/349 (5%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSA-----ANVPIKWESIDVTPSLNADGKTVIPDESI 352 +Y ++ I DGIGPE+ + + A + I E+ D ++P + + Sbjct: 3 EYKIAAIPADGIGPEVIAAGLQVLEALEQRSGDFKIHTETFDWGSDYYKKHGVMMPADGL 62 Query: 353 ASIKRNYVALKGPLATPIGKGHVSL---NLTLRRTFNLFANVRPCKSIQGYKTPYDN--- 514 +K+ G + P H++L L + + F+ +ANVRP K + G P N Sbjct: 63 DKLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGITPPLRNCGP 122 Query: 515 --VDTVLIRENTEGEYSG----IEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 +D V++REN+EGEYSG + + V + + TR R++R+AF+ AQ + Sbjct: 123 GDLDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRK 182 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 + VV K+ + ++ + E+A E+P++ +D L+D +++ P + +V Sbjct: 183 LLTVVTKSNAQRHGMVMWDEIAAEVATEFPDVTWDKMLVDAMTVRMTLKPETLD--TIVA 240 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIGDEC---SIFEAVHGSAPDIAGKGLANPTALLL 1027 NL+ DILSD+ L G LG+ P+ NI E S+FE +HGSA DI GKG+ANP A Sbjct: 241 TNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPIATFW 300 Query: 1028 SSIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAV 1174 ++ ML+H+G + A ++ +A+ + + E +T D+GG + T + AV Sbjct: 301 TAAQMLEHLGERDAAARLMSAV-ERVTEAGILTPDVGGTANTRQVTEAV 348
>Q8DTG3:LEU3_STRMU 3-isopropylmalate dehydrogenase - Streptococcus mutans| Length = 344 Score = 164 bits (414), Expect = 1e-39 Identities = 119/345 (34%), Positives = 190/345 (55%), Gaps = 18/345 (5%) Frame = +2 Query: 206 IEGDGIGPEIAQSVKDIYSAANVPIKWE-SIDVTP----SLNADGKTVIPDESIASIKRN 370 + GDGIGPEI + +++ A I ++ I+ ++A G +PD+++A+ K Sbjct: 7 LAGDGIGPEIMAAGLEVFDAVAQKINFDYEIEAKAFGGAGIDASGHP-LPDDTLAAAKTA 65 Query: 371 YVALKGPLATP-IGKGHVSLN---LTLRRTFNLFANVRPCKSIQGYK--TPYD-----NV 517 L + +P K V L +R+ NLFAN+RP + + +P V Sbjct: 66 DAILLAAIGSPQYDKAPVRPEQGLLAIRKELNLFANIRPVRIFDALRHLSPLKAERIAGV 125 Query: 518 DTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHK 697 D V++RE T G Y G +H + + I + R++R AF A+ K KV + K Sbjct: 126 DFVVVRELTGGIYFG-QHTLTENSACDINEYSASEIRRIMRKAFAIARGRSK-KVTSIDK 183 Query: 698 ATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDI 877 ++ S L+ + E+AKEY ++ + +L+D+A + ++T+P ++ V+V NL+GDI Sbjct: 184 QNVLATSK-LWRQIAEEVAKEYSDVTLEHQLVDSAAMVMITNPACFD--VVVTENLFGDI 240 Query: 878 LSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQ-H 1051 LSD + L G LG+ PS + + S++E +HGSAPDIAGKG+ANP +++LS MML+ Sbjct: 241 LSDESSVLPGTLGVMPSASHSESGPSLYEPIHGSAPDIAGKGIANPISMILSVAMMLRDS 300 Query: 1052 MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 G A I+ A+ KTL +G +T DLGG + T + AA+I NL Sbjct: 301 FGETAGAEMIEHAVNKTLTQG-ILTRDLGGLANTKQMTAAIIANL 344
>O34296:TTUC3_AGRVI Probable tartrate dehydrogenase/decarboxylase ttuC' - Agrobacterium| vitis (Rhizobium vitis) Length = 358 Score = 163 bits (413), Expect = 1e-39 Identities = 106/349 (30%), Positives = 180/349 (51%), Gaps = 20/349 (5%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSA-----ANVPIKWESIDVTPSLNADGKTVIPDESI 352 +Y ++ I DGIGPE+ + + A + I E+ D ++P + + Sbjct: 3 EYKIAAIPADGIGPEVIAAGLQVLEALEQRSGDFKIHTETFDWGSDYYKKHGVMMPADGL 62 Query: 353 ASIKRNYVALKGPLATPIGKGHVSL---NLTLRRTFNLFANVRPCKSIQGYKTPYDN--- 514 +K+ G + P H++L L + + F+ +ANVRP K + G P N Sbjct: 63 DKLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGITPPLRNCGP 122 Query: 515 --VDTVLIRENTEGEYSG----IEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 +D V++REN+EGEYSG + + V + + TR R++R+AF+ AQ + Sbjct: 123 GDLDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRK 182 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 + VV K+ + ++ + E+A E+P++ +D L+D +++ P + +V Sbjct: 183 LLTVVTKSNAQRHGMVMWDEIAAEVATEFPDVTWDKMLVDAMTVRMTLKPETLD--TIVA 240 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIGDEC---SIFEAVHGSAPDIAGKGLANPTALLL 1027 NL+ DILSD+ L G LG+ P+ NI E S+FE +HGSA DI GKG+ANP A Sbjct: 241 TNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPIATFW 300 Query: 1028 SSIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAV 1174 ++ ML+H+G + A ++ +A+ + + E +T D+GG + T + AV Sbjct: 301 TAAQMLEHLGERDAAARLMSAV-ERVTEAGILTPDVGGTANTSQVTEAV 348
>Q5M405:LEU3_STRT2 3-isopropylmalate dehydrogenase - Streptococcus thermophilus (strain| ATCC BAA-250 / LMG 18311) Length = 345 Score = 163 bits (413), Expect = 1e-39 Identities = 117/345 (33%), Positives = 190/345 (55%), Gaps = 18/345 (5%) Frame = +2 Query: 206 IEGDGIGPEIAQSVKDIYSAANVPIKWE-SIDVTP----SLNADGKTVIPDESIASIKRN 370 + GDGIGPEI + + I+++ +D P ++A+G +P ++ + K Sbjct: 8 LSGDGIGPEIMAAGLGVLDKVASKIEFDYDVDAKPFGGAGIDAEGHP-LPKATLEAAKSA 66 Query: 371 ----YVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYK-------TPYDNV 517 A+ GP L +R+ NLFAN+RP + K + V Sbjct: 67 DAILLAAIGGPKYDNAPVRPEQGLLAIRKELNLFANIRPVRIFDALKHLSPLKPERIEGV 126 Query: 518 DTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHK 697 D V++RE T G Y G EH++ + + I + + R++R AF+ AQ GK KV + K Sbjct: 127 DFVVVRELTGGIYFG-EHILEEDKARDINDYSADEIRRIMRRAFKIAQGRGK-KVTSIDK 184 Query: 698 ATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDI 877 ++ S L+ + E++ E+P++ + +L+D+A + ++T+P ++ V+V NL+GDI Sbjct: 185 QNVLATSK-LWRKVADEVSLEFPDVTLEHQLVDSAAMIMITNPARFD--VVVTENLFGDI 241 Query: 878 LSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTALLLSSIMML-QH 1051 LSD + L G LG+ PS + + S++E +HGSAPDIAG+G+ANP +++LS MML + Sbjct: 242 LSDESSVLPGTLGVMPSASHSENGPSLYEPIHGSAPDIAGQGIANPISMILSVAMMLRES 301 Query: 1052 MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 E A I+ A+ KTL +G +T DLGG++ T E AA+I NL Sbjct: 302 FNETEGAELIENAVDKTLNQG-ILTRDLGGQASTAEMTAAIISNL 345
>Q5LZF3:LEU3_STRT1 3-isopropylmalate dehydrogenase - Streptococcus thermophilus (strain| CNRZ 1066) Length = 345 Score = 163 bits (413), Expect = 1e-39 Identities = 117/345 (33%), Positives = 190/345 (55%), Gaps = 18/345 (5%) Frame = +2 Query: 206 IEGDGIGPEIAQSVKDIYSAANVPIKWE-SIDVTP----SLNADGKTVIPDESIASIKRN 370 + GDGIGPEI + + I+++ +D P ++A+G +P ++ + K Sbjct: 8 LSGDGIGPEIMAAGLGVLDKVASKIEFDYDVDAKPFGGAGIDAEGHP-LPKATLEAAKSA 66 Query: 371 ----YVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYK-------TPYDNV 517 A+ GP L +R+ NLFAN+RP + K + V Sbjct: 67 DAILLAAIGGPKYDNAPVRPEQGLLAIRKELNLFANIRPVRIFDALKHLSPLKPERIEGV 126 Query: 518 DTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHK 697 D V++RE T G Y G EH++ + + I + + R++R AF+ AQ GK KV + K Sbjct: 127 DFVVVRELTGGIYFG-EHILEEDKARDINDYSADEIRRIMRRAFKIAQGRGK-KVTSIDK 184 Query: 698 ATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDI 877 ++ S L+ + E++ E+P++ + +L+D+A + ++T+P ++ V+V NL+GDI Sbjct: 185 QNVLATSK-LWRKVADEVSLEFPDVTLEHQLVDSAAMIMITNPARFD--VVVTENLFGDI 241 Query: 878 LSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTALLLSSIMML-QH 1051 LSD + L G LG+ PS + + S++E +HGSAPDIAG+G+ANP +++LS MML + Sbjct: 242 LSDESSVLPGTLGVMPSASHSENGPSLYEPIHGSAPDIAGQGIANPISMILSVAMMLRES 301 Query: 1052 MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 E A I+ A+ KTL +G +T DLGG++ T E AA+I NL Sbjct: 302 FNETEGAELIENAVDKTLNQG-ILTRDLGGQASTAEMTAAIISNL 345
>O34295:TTUC5_AGRVI Probable tartrate dehydrogenase/decarboxylase ttuC' - Agrobacterium| vitis (Rhizobium vitis) Length = 358 Score = 163 bits (412), Expect = 2e-39 Identities = 106/349 (30%), Positives = 179/349 (51%), Gaps = 20/349 (5%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSA-----ANVPIKWESIDVTPSLNADGKTVIPDESI 352 +Y ++ I DGIGPE+ + + A + I E+ D ++P + + Sbjct: 3 EYKIAAIPADGIGPEVIAAGLQVLEALEQRSGDFKIHTETFDWGSDYYKKHGVMMPADGL 62 Query: 353 ASIKRNYVALKGPLATPIGKGHVSL---NLTLRRTFNLFANVRPCKSIQGYKTPYDN--- 514 +K+ G + P H++L L + + F+ +ANVRP K + G P N Sbjct: 63 DKLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKILPGITPPLRNCGP 122 Query: 515 --VDTVLIRENTEGEYSG----IEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 +D V++REN+EGEYSG + + V + + TR R++R+AF+ AQ + Sbjct: 123 GDLDWVIVRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRK 182 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 + VV K+ + ++ + E+A E+P++ +D L+D +++ P + +V Sbjct: 183 LLTVVTKSNAQRHGMVMWDEIAAEVATEFPDVTWDKMLVDAMTVRMTLKPETLD--TIVA 240 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIGDEC---SIFEAVHGSAPDIAGKGLANPTALLL 1027 NL+ DILSD+ L G LG+ P+ NI E S+FE +HGSA DI GKG+ANP A Sbjct: 241 TNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPIATFW 300 Query: 1028 SSIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAV 1174 ++ ML+H+G + A ++ A+ + + E +T D+GG + T + AV Sbjct: 301 TAAQMLEHLGERDAAARLMGAV-ERVTEAGILTPDVGGTANTSQVTEAV 348
>Q5SIY4:LEU3_THET8 3-isopropylmalate dehydrogenase - Thermus thermophilus (strain HB8 /| ATCC 27634 / DSM 579) Length = 345 Score = 163 bits (412), Expect = 2e-39 Identities = 116/350 (33%), Positives = 192/350 (54%), Gaps = 20/350 (5%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQS----VKDIYSAANVPIKWESIDVT-PSLNADGKTVIPDESIASI 361 V+++ GDGIGPE+ ++ ++ + A + + +E +++A G+ P+ + + Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEP-FPEPTRKGV 61 Query: 362 KRNYVALKGPLATPIGKG-------HVSLNLTLRRTFNLFANVRPCKSIQGYK--TPYDN 514 + L G + P G L L+LR++ +LFAN+RP K G + +P Sbjct: 62 EEAEAVLLGSVGGPKWDGLPRKIRPETGL-LSLRKSQDLFANLRPAKVFPGLERLSPLKE 120 Query: 515 -----VDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPK 679 VD +++RE T G Y G + + + + ++ ERV R AF+ A+ K Sbjct: 121 EIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHV 180 Query: 680 VRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMP 859 V V KA ++++ + + E+ + YP++ + + +D + +V P ++ V+V Sbjct: 181 VSV-DKANVLEVGE-FWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFD--VVVTG 236 Query: 860 NLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIM 1039 N++GDILSD+ + L G LGL PS ++G +FE VHGSAPDIAGKG+ANPTA +LS+ M Sbjct: 237 NIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAM 296 Query: 1040 MLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 ML+H GL E A K++ A+ K L E T DLGG + T + A V+++L Sbjct: 297 MLEHAFGLVELARKVEDAVAKALLE--TPPPDLGGSAGTEAFTATVLRHL 344
>P61494:LEU3_THET2 3-isopropylmalate dehydrogenase - Thermus thermophilus (strain HB27 /| ATCC BAA-163 / DSM 7039) Length = 345 Score = 162 bits (411), Expect = 2e-39 Identities = 116/350 (33%), Positives = 191/350 (54%), Gaps = 20/350 (5%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQS----VKDIYSAANVPIKWESIDVT-PSLNADGKTVIPDESIASI 361 V+++ GDGIGPE+ ++ ++ + A + + +E +++A G+ P+ + + Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEP-FPEPTRKGV 61 Query: 362 KRNYVALKGPLATPIGKG-------HVSLNLTLRRTFNLFANVRPCKSIQGYK--TPYDN 514 + L G + P G L L+LR++ +LFAN+RP K G + +P Sbjct: 62 EEAEAVLLGSVGGPKWDGLPRKIRPETGL-LSLRKSQDLFANLRPAKVFPGLERLSPLKE 120 Query: 515 -----VDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPK 679 VD +++RE T G Y G + + + + ++ ERV R AF+ A+ K Sbjct: 121 EIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHV 180 Query: 680 VRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMP 859 V V KA ++++ + + E+ + YP++ + + +D + +V P ++ V+V Sbjct: 181 VSV-DKANVLEVGE-FWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFD--VVVTG 236 Query: 860 NLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIM 1039 N++GDILSD+ + L G LGL PS ++G +FE VHGSAPDIAGKGLANPTA +LS+ M Sbjct: 237 NIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGLANPTAAILSAAM 296 Query: 1040 MLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 ML+H GL E A K++ A+ K L E DLGG + T + A V+++L Sbjct: 297 MLEHAFGLVELARKVEDAVAKALLEAP--PPDLGGSAGTEAFTATVLRHL 344
>Q8DPJ4:LEU3_STRR6 3-isopropylmalate dehydrogenase - Streptococcus pneumoniae (strain| ATCC BAA-255 / R6) Length = 345 Score = 161 bits (408), Expect = 5e-39 Identities = 117/351 (33%), Positives = 199/351 (56%), Gaps = 18/351 (5%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWE-SIDVTPSLNADGKTV---IPDESIA 355 K V+L+ GDGIGPEI ++ ++ A ++ ID P AD +PDE++ Sbjct: 3 KKIVALV-GDGIGPEIMEAGLEVLEALAEKTGFDYEIDRRPFGGADIDAAGPPLPDETLK 61 Query: 356 SIKRNYVALKGPLATPIGKGHVSLN-----LTLRRTFNLFANVRPCKSIQG--YKTPY-- 508 + + L + +P G V++ + LR+ NL+AN+RP K Y +P Sbjct: 62 ASREADAILLVAIGSPQYDG-VAVRPEQGLMALRKELNLYANIRPVKIFDSLKYLSPLKP 120 Query: 509 ---DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPK 679 VD V++RE T Y G +H++ + + I + E ER++R AF+ A++ K Sbjct: 121 ERISGVDFVVVRELTGEIYFG-DHILEERKARDINDYSYEEVERIIRKAFEIARNRRKI- 178 Query: 680 VRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMP 859 V + K ++ S L+ + E+A+++P++ + +L+D+A + ++T+P ++ V+V Sbjct: 179 VTSIDKQNVLATSK-LWRKVAEEVAQDFPDVTLEHQLVDSAAMLMITNPAKFD--VIVTE 235 Query: 860 NLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTALLLSSI 1036 NL+GDILSD + L G LG+ PS + + S++E +HGSAPDIAG+G+ANP +++LS + Sbjct: 236 NLFGDILSDESSVLSGTLGVMPSASHSENGPSLYEPIHGSAPDIAGQGIANPISMILSVV 295 Query: 1037 MMLQ-HMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 MML+ G +E +I+ A+ +LA G +T D+GG++ T E A+I L Sbjct: 296 MMLRDSFGRYEDTERIKRAVETSLAAG-ILTRDIGGQASTKEMMEAIIARL 345
>P24098:LEU3_THEAQ 3-isopropylmalate dehydrogenase - Thermus aquaticus| Length = 344 Score = 160 bits (404), Expect = 2e-38 Identities = 115/351 (32%), Positives = 188/351 (53%), Gaps = 21/351 (5%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVI-------PDESIA 355 V+++ GDGIGPE+ ++ + A + + E + +T G I P+ + Sbjct: 3 VAVLPGDGIGPEVTEAALRVLKALD---EREGLGLTYETFPFGGAAIDGYGEPFPEVTRK 59 Query: 356 SIKRNYVALKGPL------ATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYK--TPYD 511 ++ L G + A P S L LR++ +LFAN+RP K G + +P Sbjct: 60 GVEAAEAVLLGSVGGPKWDALPRKIRPESGLLALRKSQDLFANLRPAKVFPGLERLSPLK 119 Query: 512 N-----VDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 VD +++RE T G Y G + + + + ++ ERV + AF+ A+ + Sbjct: 120 EEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVAKVAFEAARK-RRR 178 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 + V KA ++++ + + E+ K YP++ D + +D + +V +P ++ V+V Sbjct: 179 HLTSVDKANVLEVGE-FWRKTVEEVHKGYPDVALDHQYVDAMAMHLVKNPARFD--VVVT 235 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSI 1036 N++GDILSD+ + L G LGL PS ++G +FE VHGSAPDIAGKG+ANPTA +LS+ Sbjct: 236 GNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAA 295 Query: 1037 MMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 MML+H GL E A +++AA+ K L E T DLGG + T + V+++L Sbjct: 296 MMLEHAFGLVELARRVEAAVAKALRE--TPPPDLGGSAGTQAFTEEVLRHL 344
>Q8EN68:LEU3_OCEIH 3-isopropylmalate dehydrogenase - Oceanobacillus iheyensis| Length = 366 Score = 160 bits (404), Expect = 2e-38 Identities = 121/354 (34%), Positives = 194/354 (54%), Gaps = 24/354 (6%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 + L+ GDGIG EI S K + +A N +E + S + T +PD+++ + Sbjct: 5 IILLPGDGIGREIIDSAKQVLTAIASEYNHRFTFEEHAIGGSAIDEYGTPLPDKTVDACS 64 Query: 365 RNYVALKGPLATP---IGKGHVSLN---LTLRRTFNLFANVRPCKSIQG--YKTPY---- 508 + L G + P H+ L +R+ LFAN+RP K+I Y +P Sbjct: 65 KADAILLGAVGGPKWDANPSHLRPEKGLLGIRKQLGLFANLRPVKTISSLLYASPLKEEI 124 Query: 509 -DNVDTVLIRENTEGEYSGI-EHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKV 682 D ++IRE T G Y G +GVV +++ +RE ER++ F+ A+ I K + Sbjct: 125 VSQADMLIIRELTGGIYFGTPSERTTNGVVDTLQY-SREEIERIVERGFEAAR-IRKKHL 182 Query: 683 RVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPN 862 V KA +++ S L+ + E +K+YP++ + L+D A +K+VT P+ ++ V+V N Sbjct: 183 TSVDKANVLESSK-LWREIVEEKSKDYPDVAVNHLLVDAAAMKLVTQPSFFD--VIVTEN 239 Query: 863 LYGDILSDMCAGLIGGLGLTPSGNI-GDECSIFEAVHGSAPDIAGKGLANPTALLLSSIM 1039 L+GDILSD + L G LG+ PS ++ D ++E VHGSAPDIAGKG+ANP A++LS+ + Sbjct: 240 LFGDILSDEASVLTGSLGMLPSASLRADGLGLYEPVHGSAPDIAGKGIANPLAMILSAAL 299 Query: 1040 MLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL----GGKSKTHEYAAAVIKNL 1186 ML+H GL + A +I+ A+ L +G T D+ G + T + AV++N+ Sbjct: 300 MLEHSFGLVDEAKEIERAVNDCLLQG-FHTADIHIPGGVQVGTKQMTDAVLENV 352
>Q6AEP6:LEU3_LEIXX 3-isopropylmalate dehydrogenase - Leifsonia xyli subsp. xyli| Length = 357 Score = 158 bits (399), Expect = 6e-38 Identities = 116/325 (35%), Positives = 179/325 (55%), Gaps = 23/325 (7%) Frame = +2 Query: 203 LIEGDGIGPE-IAQSVKDIYSA-ANVPIKWESIDVTPSLNADGKT----VIPDESIASIK 364 +I GDGIGPE IA++VK + + A + ++ SL AD V+ D+ +A+I+ Sbjct: 9 VIPGDGIGPEVIAEAVKALDAVTAGSGLAFQKTYF--SLGADRYLATGDVLTDDDLAAIR 66 Query: 365 RNYVALKGPLATPIGK-----GHVSLNLTLRRTFNL--FANVRPCKSIQGYKTPY---DN 514 + L G + G +V L LR F+L + N+RP G +P Sbjct: 67 GHDAILLGAVGGRPGDPRLAGANVERGLLLRLRFSLDHYVNLRPTTLFPGIASPLAAPGE 126 Query: 515 VDTVLIRENTEGEYSGIEHVVVDG----VVQSIKLITREASERVLRFAFQYAQDIGKPKV 682 VD V++RE TEG+Y G + G V + + T ERV+R+AF+ A K K+ Sbjct: 127 VDFVVVREGTEGQYVGNGGAIRPGTPHEVANEVSVNTAYGVERVVRYAFEQAGQRRK-KL 185 Query: 683 RVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPN 862 +VHK ++ + L+ + +A E+P + D +D A + +VTDP ++ V+V N Sbjct: 186 TLVHKTNVLTFAGSLWKRIVDALAAEHPEVAVDYLHVDAATIFLVTDPARFD--VIVTDN 243 Query: 863 LYGDILSDMCAGLIGGLGLTPSGNI---GDECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 L+GDIL+D+ A + GG+GL SGNI G+ S+FE VHGSAPDIAG+ A+PTA +LS Sbjct: 244 LFGDILTDLAAAISGGIGLAASGNINPVGEFPSMFEPVHGSAPDIAGEQRADPTAAILSV 303 Query: 1034 IMMLQHMGLFEHANKIQAAIFKTLA 1108 ++L+H+G A +++ A+ LA Sbjct: 304 ALLLRHLGERPLAERVERAVTTDLA 328
>Q5WEN4:LEU3_BACSK 3-isopropylmalate dehydrogenase - Bacillus clausii (strain KSM-K16)| Length = 364 Score = 158 bits (399), Expect = 6e-38 Identities = 117/337 (34%), Positives = 179/337 (53%), Gaps = 31/337 (9%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDI-----------YSAANVPIKWESIDVTPSLNADGKTVIPD 343 + L+ GDGIGPEI K + + I ++ID T S +P+ Sbjct: 5 ILLLPGDGIGPEIIAETKRVLEEIARLYHHTFQFVEGRIGGDAIDATGS-------PLPE 57 Query: 344 ESIASIKRNYVALKGPLATPIGKGHVSLN------LTLRRTFNLFANVRPC---KSIQGY 496 E++ K + L G + P G+ L +R+ L+AN+RP K + G Sbjct: 58 ETLDLAKGSDAILLGAVGGPKWDGNAPEKRPEKGLLQIRKALGLYANLRPVRVLKPLMGA 117 Query: 497 KTPYD----NVDTVLIRENTEGEYSGIEHVV-----VDGVVQSIKLITREASERVLRFAF 649 T + +VD +++RE T G Y G DG V ++ L TR ER++ AF Sbjct: 118 STLKEEVLADVDLLIVRELTGGLYFGEPRERRQINGEDGAVDTL-LYTRGEIERIVHQAF 176 Query: 650 QYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPT 829 Q+A+ K +V V KA +++ S L+ + E+A+EYP++ L+DNA ++++ DP Sbjct: 177 QFART-RKKRVVSVDKANVLE-SSRLWREIADEVAREYPDVTLSHMLVDNAAMQLIRDPR 234 Query: 830 PYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLA 1006 ++ V+V NL+GDILSD + + G LGL PS ++ + +FE VHGSAPDIAG G A Sbjct: 235 QFD--VIVTENLFGDILSDEASMITGSLGLLPSASMNTSKVGLFEPVHGSAPDIAGTGAA 292 Query: 1007 NPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 NP A +LS+ MMLQ+ GL + A I+ A+ + LA+G Sbjct: 293 NPLATILSAAMMLQYSFGLADEAKAIEVAVDRVLAQG 329
>O33117:LEU3_MYCLE 3-isopropylmalate dehydrogenase - Mycobacterium leprae| Length = 336 Score = 157 bits (396), Expect = 1e-37 Identities = 103/330 (31%), Positives = 179/330 (54%), Gaps = 16/330 (4%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 +++I GDGIGPE+ I ++ + D+ ++P+ +A ++ + Sbjct: 3 LAIIGGDGIGPEVVAQAVKILDVVLPGVQKTTYDLGARRYHTTGELLPESVLAELREHDA 62 Query: 377 ALKGPLATP-IGKGHVSLNLTLRRTFNL--FANVRPCKSIQGYKTPY---DNVDTVLIRE 538 L G + P + G + L LR F L N+RP + G + ++D V++RE Sbjct: 63 ILLGAVGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVNSLLAGKPDIDFVVVRE 122 Query: 539 NTEGEYSGIEHVVVDG----VVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATI 706 TEG Y+G + G V + + T RV++ AF+ A+ K + +VHK + Sbjct: 123 GTEGPYTGTGGAIRVGTPNEVATEVSVNTAFGVRRVVQDAFERARQRRK-HLTLVHKNNV 181 Query: 707 MKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSD 886 + + L+ + +E+ ++YP++E + +D A + +VT+P+ ++ V+V NL+GDI++D Sbjct: 182 LTYAGTLWCRIVQEVGEKYPDVEVVYQHIDAATIYLVTEPSRFD--VIVTDNLFGDIITD 239 Query: 887 MCAGLIGGLGLTPSGNIG---DECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMG 1057 + A + GG+ L SGNI S+FE VHGSAPDIAG+G+A+PTA ++S ++L H+G Sbjct: 240 LAAAVCGGIALAASGNIDATRTNPSMFEPVHGSAPDIAGQGIADPTAAIMSLALLLAHLG 299 Query: 1058 LFEHANKIQAAIFKTLA---EGKTITGDLG 1138 E A ++ A+ LA G+ TG++G Sbjct: 300 EDEPAARLDQAVASYLATRGNGRFSTGEVG 329
>Q65GI9:LEU3_BACLD 3-isopropylmalate dehydrogenase - Bacillus licheniformis (strain DSM| 13 / ATCC 14580) Length = 370 Score = 154 bits (390), Expect = 6e-37 Identities = 115/345 (33%), Positives = 188/345 (54%), Gaps = 24/345 (6%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIA 355 K ++L+ GDGIGPE+ + D+ + ++E + + + +P+E++A Sbjct: 2 KKRIALLPGDGIGPEVLDAAVDVLKSVAEHYQHEFEFEYGLIGGAAIDEAGAPLPEETVA 61 Query: 356 SIKRNYVALKGPLATPIGKGHVSLN------LTLRRTFNLFANVRPCKSIQGY------K 499 + K L G + P + S L +R+ +LFAN+RP K + K Sbjct: 62 ACKAADAILLGAVGGPKWDQNPSELRPEKGLLAIRKQLDLFANLRPVKVFESLAGASPLK 121 Query: 500 TPY-DNVDTVLIRENTEGEYSGI---EHVVVDGVVQSIKLITREASE--RVLRFAFQYAQ 661 T Y + VD V++RE T G Y G ++V +G +++ + + SE RV+R AFQ AQ Sbjct: 122 TEYIEGVDFVIVRELTGGLYFGKPSEQYVNQNGEEEAVDTLFYKKSEMERVIREAFQMAQ 181 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 K KV V KA +++ S L+ E+AKE+P+++ + L+DNA ++++ P ++ Sbjct: 182 S-RKGKVTSVDKANVLESSK-LWRKTAEEVAKEFPDVKLEHMLVDNAAMQLIYAPGQFD- 238 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTA 1018 ++V N++GDILSD + L G LG+ PS ++ ++E VHGSAPDIAG+ +ANP A Sbjct: 239 -IIVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHLYEPVHGSAPDIAGQNIANPLA 297 Query: 1019 LLLSSIMMLQ-HMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSK 1150 +LS+ MML+ GL A ++ A+ + L GK T DL S+ Sbjct: 298 AILSAAMMLRTSFGLEAEAQAVEHAVDQVLRAGKR-TKDLAKGSE 341
>P50214:IDH_ANASP Isocitrate dehydrogenase [NADP] - Anabaena sp. (strain PCC 7120)| Length = 473 Score = 154 bits (389), Expect = 8e-37 Identities = 134/446 (30%), Positives = 202/446 (45%), Gaps = 117/446 (26%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVP-------IKWESI---DVTPSLNADGKTVIPDE 346 + I GDG G +I + + + AA I W + D L + +P++ Sbjct: 29 IPFIRGDGTGIDIWPATEKVLDAAVAKAYQGKRKISWFKVYAGDEACDLYGTYQ-YLPED 87 Query: 347 SIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDN---V 517 ++ +I+ VA+KGPL TP+G G SLN+ LR+ F+L+A VRPC+ G +P+ N + Sbjct: 88 TLTAIREYGVAIKGPLTTPVGGGIRSLNVALRQIFDLYACVRPCRYYAGTPSPHKNPEKL 147 Query: 518 DTVLIRENTEGEYSGIE-----------------------------HVVVDGVVQSIKLI 610 D ++ RENTE Y GIE + +D + IK I Sbjct: 148 DVIVYRENTEDIYLGIEWKQGSEIGDRLISILNKELIPATPEHGKKQIPLDSGI-GIKPI 206 Query: 611 TREASERVLRFAFQYAQDIGKPK--VRVVHKATIMKMSDGLFLNLGREIA---------- 754 ++ S+R++R A ++A + K K V +VHK IMK ++G F + G E+A Sbjct: 207 SKTGSQRLVRRAIKHALTLPKDKQQVTLVHKGNIMKYTEGAFRDWGYELATSEFRQETVT 266 Query: 755 ----------KEYPNIE-----------FDAELLDNACLKVVTDPTPYN----------- 838 ++ PNI FDA + V T N Sbjct: 267 ERESWILSNKEKNPNISLEDNARQIDPGFDALTPEKKAQIVKEVETVLNSIWESHGNGKW 326 Query: 839 -DKVLV--------------MPNLY---------GDILSDMCAGLIGGLGLTPSGNIGDE 946 +KVLV P+ Y GD LSD A ++GGLG+ P NIGD Sbjct: 327 KEKVLVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGMGPGANIGDS 386 Query: 947 CSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIFKTLAEGKTIT 1126 C++FEA HG+AP AG NP +++LS +MML++MG E A+ I+ + +A + +T Sbjct: 387 CAVFEATHGTAPKHAGLDRINPGSVILSGVMMLEYMGWQEAADLIKKGLSDAIANSQ-VT 445 Query: 1127 GDLG-------GKSKTHEYAAAVIKN 1183 DL K E+A A+IK+ Sbjct: 446 YDLARLLEPPVEPLKCSEFADAIIKH 471
>Q73VI1:LEU3_MYCPA 3-isopropylmalate dehydrogenase - Mycobacterium paratuberculosis| Length = 336 Score = 154 bits (388), Expect = 1e-36 Identities = 102/317 (32%), Positives = 168/317 (52%), Gaps = 13/317 (4%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 +++I GDGIGPE+ + A + D+ ++PD I ++ + Sbjct: 3 LAVIGGDGIGPEVTAEALKVLDAVLPGVDKTEYDLGARRYHATGELLPDSVIDELRAHDA 62 Query: 377 ALKGPLATP-IGKGHVSLNLTLRRTFNL--FANVRPCKSIQGYKTPY---DNVDTVLIRE 538 L G + P + G + L LR F L N+RP + G +P ++D V++RE Sbjct: 63 ILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPGRLYPGVSSPLAGNPDIDFVVVRE 122 Query: 539 NTEGEYSGIEHVVVDG----VVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATI 706 TEG Y+G + G V + T RV+ AF+ A+ K + +VHK + Sbjct: 123 GTEGPYTGTGGAIRVGTPNEVATEVSQNTAFGVRRVVVDAFERARRRRK-HLTLVHKTNV 181 Query: 707 MKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSD 886 + + L+ + E+ ++YP++E + +D A + +VTDP ++ V+V NL+GDI++D Sbjct: 182 LTFAGKLWSRIVAEVGRDYPDVEVAYQHIDAATIFMVTDPGRFD--VIVTDNLFGDIITD 239 Query: 887 MCAGLIGGLGLTPSGNIGD---ECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMG 1057 + A + GG+GL SGNI S+FE VHGSAPDIAG+G+A+PTA ++S ++L H+G Sbjct: 240 LSAAVCGGIGLAASGNIDGTRTNPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLAHLG 299 Query: 1058 LFEHANKIQAAIFKTLA 1108 A ++ A+ + LA Sbjct: 300 EDAAATRVDRAVERYLA 316
>Q51945:TTUC_PSEPU Tartrate dehydrogenase/decarboxylase - Pseudomonas putida| Length = 365 Score = 152 bits (385), Expect = 2e-36 Identities = 112/362 (30%), Positives = 179/362 (49%), Gaps = 30/362 (8%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVP---------IKWESIDVTPSLNADGKTVIPD 343 + ++ I GDGIG E+ + AA + +W S D GK ++PD Sbjct: 6 FRIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQ---HGK-MMPD 61 Query: 344 ESIASIKRNYVALKGPLATPIG-KGHVSL---NLTLRRTFNLFANVRPCKSIQGYKTPYD 511 + +K+ G + P H+SL L RR F+ + N+RP + G Sbjct: 62 DWAEQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCALA 121 Query: 512 N-----VDTVLIRENTEGEYSGIEHVVVDGVVQSI----KLITREASERVLRFAFQYAQD 664 N +D V++RENTEGEYS + ++ + I + TR +R+L++AF A+ Sbjct: 122 NRKVGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAEK 181 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 + V K+ M +S + +A YP++ +D + +D C + V P + D Sbjct: 182 RERKHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERF-DV 240 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC---SIFEAVHGSAPDIAGKGLANPT 1015 V+V NL+GDILSD+ G +G+ PS N+ E S+FE VHGSAPDI GK +ANP Sbjct: 241 VVVASNLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPI 300 Query: 1016 ALLLSSIMMLQHMGLFEHA-----NKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIK 1180 A++ S +ML+ +G + + + AI + +A+G ++T D+GG T + AA+ Sbjct: 301 AMIWSGALMLEFLGQGDERYQRAHDDMLNAIERVIADG-SVTPDMGGTLSTQQVGAAISD 359 Query: 1181 NL 1186 L Sbjct: 360 TL 361
>P59028:LEU3_CHLTE 3-isopropylmalate dehydrogenase - Chlorobium tepidum| Length = 352 Score = 152 bits (383), Expect = 4e-36 Identities = 116/355 (32%), Positives = 176/355 (49%), Gaps = 23/355 (6%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGK-----TVIPDESIA 355 Y + I GDGIGPE+ D+ +A +E + V L +++ DE++ Sbjct: 3 YKIVSIPGDGIGPEVVAGALDVLNAVAKKHGFE-VSVEEHLFGGASYDVHGSMLTDETLE 61 Query: 356 SIKRNYVALKGPLA------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY------K 499 + K L G + P K + L +R+ LFAN+RP + K Sbjct: 62 ACKNCDAVLLGAVGGYKWENLPHDKKPEAALLKIRKELGLFANLRPARVYDALVASSTLK 121 Query: 500 TPY-DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 T D ++ RE T G Y G + + + R ER+ R AF+YAQ G Sbjct: 122 TEVVQGTDFMVFRELTGGIYFGQPRGYDETRGWNTMVYERYEVERIARLAFEYAQKRGNA 181 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 KV + KA ++++S + N+ E+ +++P IE +DNA ++VV +P + +V+V Sbjct: 182 KVTSIDKANVLEVSQ-FWRNIVHEVHQDFPEIELVDMYVDNAAMQVVRNPKQF--EVIVT 238 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSI 1036 NL+GDILSD+ + G LG+ PS +IG E +++E +HGSAPDIAG+ ANP A + S Sbjct: 239 SNLFGDILSDISGMITGSLGMLPSASIGSEHALYEPIHGSAPDIAGQNKANPIATIASVA 298 Query: 1037 MMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGK----SKTHEYAAAVIKNL 1186 MM ++ E A I AAI LA G TGD+ S T E AA++ + Sbjct: 299 MMFENSFNRPEVAADIYAAIEGALAAGFR-TGDIAAAGEAISSTTEMTAAIVARI 352
>P12010:LEU3_BACCO 3-isopropylmalate dehydrogenase - Bacillus coagulans| Length = 366 Score = 151 bits (381), Expect = 7e-36 Identities = 113/343 (32%), Positives = 185/343 (53%), Gaps = 27/343 (7%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQS----VKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIA 355 K ++++ GDGIGPE+ + +K + +E+ + + + T +P+E++ Sbjct: 2 KMKLAVLPGDGIGPEVMDAAIRVLKTVLDNDGHEAVFENALIGGAAIDEAGTPLPEETLD 61 Query: 356 SIKRNYVALKGPLATPIGKGH-VSLN-----LTLRRTFNLFANVRPCKSIQGY------- 496 +R+ L G + P + SL L LR+ LFAN+RP K+ Sbjct: 62 ICRRSDAILLGAVGGPKWDHNPASLRPEKGLLGLRKEMGLFANLRPVKAYATLLNASPLK 121 Query: 497 KTPYDNVDTVLIRENTEGEYSGI--------EHVVVDGVVQSIKLITREASERVLRFAFQ 652 + +NVD V++RE T G Y G E+ VVD + TRE ER++ AFQ Sbjct: 122 RERVENVDLVIVRELTGGLYFGRPSERRGPGENEVVDTLAY-----TREEIERIIEKAFQ 176 Query: 653 YAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTP 832 AQ I + K+ V KA +++ S ++ + E AK+YP++E L+D+ ++++ +P Sbjct: 177 LAQ-IRRKKLASVDKANVLE-SSRMWREIAEETAKKYPDVELSHMLVDSTSMQLIANPGQ 234 Query: 833 YNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNI-GDECSIFEAVHGSAPDIAGKGLAN 1009 ++ V+V N++GDILSD + + G LG+ PS ++ D ++E VHGSAPDIAG+G AN Sbjct: 235 FD--VIVTENMFGDILSDEASVITGSLGMLPSASLRSDRFGMYEPVHGSAPDIAGQGKAN 292 Query: 1010 PTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 P +LS+ +ML++ GL + A I+ A+ L +G TGDL Sbjct: 293 PLGTVLSAALMLRYSFGLEKEAAAIEKAVDDVLQDG-YCTGDL 334
>P42958:TTUC_BACSU Probable tartrate dehydrogenase/decarboxylase - Bacillus subtilis| Length = 354 Score = 150 bits (379), Expect = 1e-35 Identities = 116/357 (32%), Positives = 187/357 (52%), Gaps = 24/357 (6%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEI-AQSVKDIYSAANV----PIKWESIDVTPSLNADGKTVIPDESI 352 ++ ++ I GDG+G E+ A + K +++AA V + + + + ++P++ I Sbjct: 5 QFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTAFPWSCDYYLEHGKMMPEDGI 64 Query: 353 ASIKRNYVALKGPLATP-IGKGHVSL---NLTLRRTFNLFANVRPCKSIQGYKTPY---D 511 ++ + G + P + H+SL L +RR L N+RP K + G +P + Sbjct: 65 HTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPLLHPN 124 Query: 512 NVDTVLIRENTEGEYS---GIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKV 682 + D V+IREN+EGEYS G H D + + TR+A+ERV+RFAF+ A K Sbjct: 125 DFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVFTRKATERVMRFAFELA------KK 178 Query: 683 RVVHKATIMKMSDGLFLNLG------REIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 R H + K S+G++ + ++ A +Y IE ++ +D VT P ++ Sbjct: 179 RRSHVTSATK-SNGIYHAMPFWDEVFQQTAADYSGIETSSQHIDALAAFFVTRPETFD-- 235 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNI---GDECSIFEAVHGSAPDIAGKGLANPT 1015 V+V L+GDIL+D+ + L+ +G+ P NI G S+FE VHGSAPDIAG+GLANP Sbjct: 236 VIVASKLFGDILTDISSSLMESIGIAPPANINPSGKYPSMFEPVHGSAPDIAGQGLANPI 295 Query: 1016 ALLLSSIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 + ++ +ML H G E KI + + A+G T D+GG+S T E + L Sbjct: 296 GQIWTAKLMLDHFGEEELGAKILDVMEQVTADG-IKTRDIGGQSTTAEVTDEICSRL 351
>Q7M886:LEU3_WOLSU 3-isopropylmalate dehydrogenase - Wolinella succinogenes| Length = 358 Score = 150 bits (379), Expect = 1e-35 Identities = 111/327 (33%), Positives = 172/327 (52%), Gaps = 18/327 (5%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESID---VTPSLNADGKTV-IPDESIA 355 KY +++I+GDGIGPEI K + A + +E + + D V +PDE+I Sbjct: 3 KYEIAIIKGDGIGPEIVDEAKKVLDAISYSHGFELSYHDYLMGGIAVDRAGVPLPDETIE 62 Query: 356 SIKRNYVALKGPL------ATPIGKGHVSLNLTLRRTFNLFANVRPC-------KSIQGY 496 R L G + + P S L LR++ +FAN+RP ++ Sbjct: 63 GCLRADAVLFGAIGGEKWDSLPRELRPESGLLKLRKSLEIFANLRPTVVYDELIEASTLK 122 Query: 497 KTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 ++ VD +++RE G Y G + + + ER+ AF+ A K Sbjct: 123 ESVIKGVDILVVRELIGGIYFGEPKGREGDKAFNTMVYSVPEIERIAHVAFKAAMRRQK- 181 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 +V V KA ++ +S L+ IAKEYP +E +DNA ++++ +P ++ V++ Sbjct: 182 RVCSVDKANVLDVSQ-LWRETVTRIAKEYPEVELSHMYIDNAAMQLIRNPKQFD--VILT 238 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSI 1036 NL+GDILSD + L G +GL PS +IG + +++E +HGSAPDIAG+G+ANP A + S+ Sbjct: 239 GNLFGDILSDEASMLSGSIGLLPSASIGGKAALYEPIHGSAPDIAGQGIANPIATIASAS 298 Query: 1037 MMLQH-MGLFEHANKIQAAIFKTLAEG 1114 MML+H +G E A+ I AI KTL EG Sbjct: 299 MMLRHSLGEVEAADAIDKAIVKTLKEG 325
>Q6HLF2:LEU3_BACHK 3-isopropylmalate dehydrogenase - Bacillus thuringiensis subsp.| konkukian Length = 354 Score = 150 bits (379), Expect = 1e-35 Identities = 113/349 (32%), Positives = 175/349 (50%), Gaps = 22/349 (6%) Frame = +2 Query: 206 IEGDGIGPEIAQSVKDI-----------YSAANVPIKWESIDVTPSLNADGKTVIPDESI 352 + GDG+GPE+ +S K + + + +ID+T +P ++ Sbjct: 8 LAGDGVGPEVMESAKGVLHMVERLYGHHFHLQDEHFGGVAIDLTGQ-------PLPQRTL 60 Query: 353 ASIKRNYVALKGPLATPIGKGHVSLN----LTLRRTFNLFANVRPC--KSIQGYKTPY-- 508 A+ + L G + P G L LR+ +FANVRP +S + +P Sbjct: 61 AACLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK 120 Query: 509 -DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVR 685 D +D V++RE T G Y D V R ER++ +AFQ A K KV Sbjct: 121 ADEIDFVVVRELTGGIYFSYPKKRTDEVATDTLTYHRHEIERIVSYAFQLASK-RKKKVT 179 Query: 686 VVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNL 865 + KA +++ S L+ + E+A YP++E + L+D A ++++ +P ++ V+V NL Sbjct: 180 SIDKANVLESSK-LWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFD--VIVTENL 236 Query: 866 YGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTALLLSSIMM 1042 +GDILSD + L G LG+ PS + ++ S++E +HGSAPDIAGK ANP A++ S MM Sbjct: 237 FGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMM 296 Query: 1043 L-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 L Q GL I+ AI L GK T D+GG T + AV++ + Sbjct: 297 LGQSFGLTREGCAIEEAISAVLKSGK-CTADIGGAETTTSFTKAVMQEM 344
>P76251:TTUC_ECOLI Probable tartrate dehydrogenase/decarboxylase - Escherichia coli| Length = 361 Score = 150 bits (378), Expect = 2e-35 Identities = 117/358 (32%), Positives = 182/358 (50%), Gaps = 30/358 (8%) Frame = +2 Query: 197 VSLIEGDGIGPEIA-QSVKDIYSAAN--------VPIKWESIDVTPSLNADGKTVIPDES 349 ++ I GDGIG E+ + ++ + +AA ++W S + + GK ++PD+ Sbjct: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEY---YSHHGK-MMPDDW 62 Query: 350 IASIKRNYVALKGPLATP-IGKGHVSL---NLTLRRTFNLFANVRPCKSIQGYKTPY--- 508 + R G + P H+SL L RR F+ + N+RP + G P Sbjct: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 Query: 509 --DNVDTVLIRENTEGEYSGIEHVVVDG----VVQSIKLITREASERVLRFAFQYAQDIG 670 ++D ++RENTEGEYS + V +G VV + TR +R+LR+AF+ AQ Sbjct: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 Query: 671 KPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVL 850 + + K+ + +S + +A+ YP I +D + +D C + V P ++ V+ Sbjct: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VV 240 Query: 851 VMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC---SIFEAVHGSAPDIAGKGLANPTAL 1021 V NL+GDILSD+ G +G+ PS N+ E S+FE VHGSAPDI GK +ANP A Sbjct: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 Query: 1022 LLSSIMMLQHMG----LFEHA-NKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIK 1180 + + MML +G F+ A N I AAI + +A G T D+ G + T + A A+ K Sbjct: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICK 357
>Q63DX7:LEU3_BACCZ 3-isopropylmalate dehydrogenase - Bacillus cereus (strain ZK / E33L)| Length = 354 Score = 150 bits (378), Expect = 2e-35 Identities = 113/349 (32%), Positives = 176/349 (50%), Gaps = 22/349 (6%) Frame = +2 Query: 206 IEGDGIGPEIAQSVKDI-----------YSAANVPIKWESIDVTPSLNADGKTVIPDESI 352 + GDG+GPE+ +S K++ + + +ID+T +P ++ Sbjct: 8 LAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQ-------PLPQRTL 60 Query: 353 ASIKRNYVALKGPLATPIGKGHVSLN----LTLRRTFNLFANVRPC--KSIQGYKTPY-- 508 A+ + L G + P G L LR+ +FANVRP +S + +P Sbjct: 61 AACLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESETAHLSPLKK 120 Query: 509 -DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVR 685 D +D V++RE T G Y D V R ER++ +AFQ A K KV Sbjct: 121 ADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSYAFQLASK-RKKKVT 179 Query: 686 VVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNL 865 + KA +++ S L+ + E+A YP++E + L+D A ++++ +P ++ V+V NL Sbjct: 180 SIDKANVLESSK-LWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFD--VIVTENL 236 Query: 866 YGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTALLLSSIMM 1042 +GDILSD + L G LG+ PS + ++ S++E +HGSAPDIAGK ANP A++ S MM Sbjct: 237 FGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMM 296 Query: 1043 L-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 L Q GL I+ AI L GK T D+GG T + AV++ + Sbjct: 297 LGQSFGLTREGCAIEEAISAVLKSGK-CTEDIGGTETTTSFTKAVMQEM 344
>Q81G11:LEU3_BACCR 3-isopropylmalate dehydrogenase - Bacillus cereus (strain ATCC 14579| / DSM 31) Length = 354 Score = 150 bits (378), Expect = 2e-35 Identities = 112/349 (32%), Positives = 175/349 (50%), Gaps = 22/349 (6%) Frame = +2 Query: 206 IEGDGIGPEIAQSVKDI-----------YSAANVPIKWESIDVTPSLNADGKTVIPDESI 352 + GDG+GPE+ +S K++ + + +ID+T +P ++ Sbjct: 8 LAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEYFGGVAIDLTGQ-------PLPQRTL 60 Query: 353 ASIKRNYVALKGPLATPIGKGHVSLN----LTLRRTFNLFANVRP--CKSIQGYKTPY-- 508 A+ + L G + P L LR+ +FANVRP +S + +P Sbjct: 61 AACLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKN 120 Query: 509 -DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVR 685 D +D V++RE T G Y + V R ER++ +AFQ A K KV Sbjct: 121 ADEIDFVVVRELTGGIYFSYPKERTEEVATDTLTYHRHEIERIVSYAFQLANK-RKKKVT 179 Query: 686 VVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNL 865 + KA +++ S L+ + E+A YPN+E + L+D A ++++ +P ++ V+V NL Sbjct: 180 SIDKANVLE-SSKLWRTVTEEVALRYPNVEVEHILVDAAAMELIRNPGRFD--VIVTENL 236 Query: 866 YGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTALLLSSIMM 1042 +GDILSD + L G LG+ PS + ++ S++E +HGSAPDIAGK ANP A++ S MM Sbjct: 237 FGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMM 296 Query: 1043 L-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 L Q GL I+ A+ L GK T D+GG T + AVI+ + Sbjct: 297 LGQSFGLTREGYAIEEAVSAVLKSGK-CTADIGGTETTTSFTKAVIQEM 344
>Q81T67:LEU3_BACAN 3-isopropylmalate dehydrogenase - Bacillus anthracis| Length = 354 Score = 148 bits (374), Expect = 5e-35 Identities = 113/349 (32%), Positives = 175/349 (50%), Gaps = 22/349 (6%) Frame = +2 Query: 206 IEGDGIGPEIAQSVKDI-----------YSAANVPIKWESIDVTPSLNADGKTVIPDESI 352 + GDG+GPE+ +S K++ + + +ID+T +P ++ Sbjct: 8 LAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEHFGGVAIDLTGQ-------PLPQRTL 60 Query: 353 ASIKRNYVALKGPLATPIGKGHVSLN----LTLRRTFNLFANVRPC--KSIQGYKTPY-- 508 A+ + L G + P G L LR+ +FANVRP +S + +P Sbjct: 61 AACLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKK 120 Query: 509 -DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVR 685 D +D V++RE T G Y D V R ER++ AFQ A K KV Sbjct: 121 ADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSCAFQLASK-RKKKVT 179 Query: 686 VVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNL 865 + KA +++ S L+ + E+A YP++E + L+D A ++++ +P ++ V+V NL Sbjct: 180 SIDKANVLESSK-LWRIVTEEVALRYPDVELEHILVDAAAMELIRNPGRFD--VIVTENL 236 Query: 866 YGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTALLLSSIMM 1042 +GDILSD + L G LG+ PS + ++ S++E +HGSAPDIAGK ANP A++ S MM Sbjct: 237 FGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMM 296 Query: 1043 L-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 L Q GL I+ AI L GK T D+GG T + AV++ + Sbjct: 297 LGQSFGLTREGCAIEEAISAVLKSGK-CTADIGGTETTTSFTKAVMQEM 344
>Q73B99:LEU3_BACC1 3-isopropylmalate dehydrogenase - Bacillus cereus (strain ATCC 10987)| Length = 354 Score = 147 bits (372), Expect = 8e-35 Identities = 111/344 (32%), Positives = 179/344 (52%), Gaps = 17/344 (4%) Frame = +2 Query: 206 IEGDGIGPEIAQSVKDIYSAA------NVPIKWESIDVTPSLNADGKTVIPDESIASIKR 367 + GDG+GPE+ +S K++ + ++ E + +++ +G+ +P ++A+ Sbjct: 8 LAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEYFGGS-AIDLNGQP-LPQRTLAACLA 65 Query: 368 NYVALKGPLATPIGKGHVSLN----LTLRRTFNLFANVRP--CKSIQGYKTPY---DNVD 520 + L G + P L LR+ +FANVRP +S + +P D +D Sbjct: 66 SDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKKADEID 125 Query: 521 TVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKA 700 V++RE T G Y D V R ER++ +AFQ A K KV + KA Sbjct: 126 FVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSYAFQLASK-RKKKVTSIDKA 184 Query: 701 TIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDIL 880 +++ S L+ + E+A YP++E + L+D A ++++ +P ++ V+V NL+GDIL Sbjct: 185 NVLE-SSKLWRTVTEEVALRYPDVELEHILVDAAAMELIRNPGRFD--VIVTENLFGDIL 241 Query: 881 SDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTALLLSSIMML-QHM 1054 SD + L G LG+ PS + ++ S++E +HGSAPDIAGK ANP A++ S MML Q Sbjct: 242 SDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVAMMLGQSF 301 Query: 1055 GLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 GL I+ AI L GK T D+GG T + AV++ + Sbjct: 302 GLTREGCAIEEAISAVLKLGK-CTADIGGTETTTSFTKAVMQEM 344
>O66607:LEU3_AQUAE 3-isopropylmalate dehydrogenase - Aquifex aeolicus| Length = 364 Score = 147 bits (371), Expect = 1e-34 Identities = 106/331 (32%), Positives = 178/331 (53%), Gaps = 22/331 (6%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAAN--VPIKWESIDVTPSLNADGKT--VIPDESIA 355 KY +++++GDGIGPEI + + +++E + A KT +P+E++ Sbjct: 3 KYKIAVLKGDGIGPEIVEQALRVLDKIGEIYGVEFEYREGLIGGEAIDKTGDPLPEETLK 62 Query: 356 SIKRNYVALKGPLA------TPIGKGHVSLNLTLRRTFNLFANVRPCK-------SIQGY 496 K + L G + P K L +R+ +L+AN+RP K S Sbjct: 63 ICKESDAILLGAVGGPKWDNLPTDKRPEKGLLRIRKELDLYANLRPAKVWDALISSSPLK 122 Query: 497 KTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASE----RVLRFAFQYAQD 664 + D ++IRE T G Y G + + + + T + +E R++R F+ A+ Sbjct: 123 EEVVKGTDMIVIRELTSGIYYGEPRGIFEENGKRYAINTMKYTEDEIRRIVRKGFEIARK 182 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 K K+ V KA ++++S L+ + E + YP++E + +DN +++V PT ++ Sbjct: 183 RRK-KLTSVDKANVLEVS-ALWRQIVEEEKENYPDVELEHLYIDNCAMQLVRRPTSFD-- 238 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALL 1024 V+V N++GDILSD ++G LG+ PS +IGD +++E VHGSAPDIAGKG+ANP A + Sbjct: 239 VIVTGNIFGDILSDEAGVVVGSLGMLPSASIGDRYALYEPVHGSAPDIAGKGIANPIATI 298 Query: 1025 LSSIMMLQHMGLFEHANK-IQAAIFKTLAEG 1114 LS+ MML++ + A+ I+ AI +TL +G Sbjct: 299 LSAAMMLKYSFNMDKAHDLIEKAIEETLNQG 329
>Q92A27:LEU3_LISIN 3-isopropylmalate dehydrogenase - Listeria innocua| Length = 350 Score = 147 bits (370), Expect = 1e-34 Identities = 113/349 (32%), Positives = 177/349 (50%), Gaps = 17/349 (4%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKDIYSAANVPIKWESIDVTP----SLNADGKTVIPDESIA 355 Y ++ + GDGIGPEI A +K + + A I+ P ++A G + P+ A Sbjct: 3 YKITSLAGDGIGPEIMASGIKILEAIAAKYNHTFEIESHPFGGAGIDAAGDPIPPETLKA 62 Query: 356 SIKRNYV---ALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY-------KTP 505 + + A+ GP K L LR+ LFAN+RP + K Sbjct: 63 CQNADAILLGAIGGPKWDNAPKRPEDGLLALRKALGLFANIRPIQVPSSITHLSPLKKEI 122 Query: 506 YDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPKVR 685 +N D V++RE T G Y G D TR ER++ AF+ A K KV Sbjct: 123 VENTDFVVVRELTGGLYFGEPKHWDDVAAVDSLTYTRVEIERIIEKAFEIASTRNK-KVT 181 Query: 686 VVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNL 865 V KA ++ S L+ + E+A +P+I + +D A + ++ PT ++ V+V NL Sbjct: 182 SVDKANVLASSK-LWRKIAEEVASRHPDITLEHLYVDAAAMLMIQRPTTFD--VIVTENL 238 Query: 866 YGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTALLLS-SIM 1039 +GDILSD + + G LG+ PS + + S++E +HGSAPDIA + +ANP +++ S S+M Sbjct: 239 FGDILSDEASVITGSLGMLPSASHAENGPSLYEPIHGSAPDIANQNIANPMSMISSVSMM 298 Query: 1040 MLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 + Q LF+ A+ I AA +T+ G +T DLGG + T ++ V+K + Sbjct: 299 LRQSFSLFKEADAIDAATARTMQAG-FLTADLGGNTSTTDFTNEVLKQI 346
>Q8Y5R8:LEU3_LISMO 3-isopropylmalate dehydrogenase - Listeria monocytogenes| Length = 350 Score = 144 bits (364), Expect = 7e-34 Identities = 114/357 (31%), Positives = 177/357 (49%), Gaps = 25/357 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAA-----------NVPIKWESIDVTPSLNADGKTVI 337 Y ++ + GDGIGPEI S + A + P IDV + I Sbjct: 3 YKITSLAGDGIGPEIMTSGLQVLEAVAKKYNHTFEIESHPFGGAGIDVA-------QDPI 55 Query: 338 PDESIASIKRNYVALKGPLATP----IGKGHVSLNLTLRRTFNLFANVRPCKSIQGY--- 496 P ++ + + L G + P K L LR+ LFAN+RP + Sbjct: 56 PSSTLKACQDADAILLGAIGGPKWDNAPKRPEDGLLALRKALGLFANIRPIQVPSSITHL 115 Query: 497 ----KTPYDNVDTVLIRENTEGEYSGI-EHVVVDGVVQSIKLITREASERVLRFAFQYAQ 661 K +N D V++RE T G Y G +H V S+ TR ER++ AF+ A Sbjct: 116 SPLKKEIVENTDFVVVRELTGGLYFGEPKHWDESAAVDSLTY-TRAEIERIIEKAFEIAA 174 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 K KV V KA ++ S L+ + E+A +P+I + +D A + ++ PT ++ Sbjct: 175 TRNK-KVTSVDKANVLASSK-LWRKIAEEVASRHPDITLEHLYIDAAAMLMIQRPTTFD- 231 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTA 1018 V+V NL+GDILSD + + G LG+ PS + + S++E +HGSAPDIA + +ANP + Sbjct: 232 -VIVTENLFGDILSDEASVITGSLGMLPSASHAENGPSLYEPIHGSAPDIANQNIANPMS 290 Query: 1019 LLLS-SIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 ++ S S+M+ Q LF+ A+ I AA +T+ G +T DLGG + T ++ V+K + Sbjct: 291 MISSVSMMLRQSFSLFKEADAIDAAATRTMQAG-FLTADLGGNTTTTDFTNEVLKQI 346
>Q71Y34:LEU3_LISMF 3-isopropylmalate dehydrogenase - Listeria monocytogenes serotype 4b| (strain F2365) Length = 350 Score = 144 bits (364), Expect = 7e-34 Identities = 112/356 (31%), Positives = 173/356 (48%), Gaps = 24/356 (6%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAA-----------NVPIKWESIDVTPSLNADGKTVI 337 Y ++ + GDGIGPEI S + A + P IDV + I Sbjct: 3 YKITSLAGDGIGPEIMTSGLQVLEAVAKKYNHTFEIESHPFGGAGIDVA-------QDPI 55 Query: 338 PDESIASIKRNYVALKGPLATP----IGKGHVSLNLTLRRTFNLFANVRPCKSIQGY--- 496 P ++ + + L G + P K L LR+ LFAN+RP + Sbjct: 56 PSSTLKACRDADAILLGAIGGPKWDNAPKRPEDGLLALRKALGLFANIRPIQVPSSITHL 115 Query: 497 ----KTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQD 664 K +N D V++RE T G Y G + TR ER++ AF+ A Sbjct: 116 SPLKKEIVENTDFVVVRELTGGLYFGEPKYWDNEAAVDSLTYTRAEIERIIEKAFEIAAT 175 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 K KV V KA ++ S L+ + E+A +P+I + +D A + ++ PT ++ Sbjct: 176 RNK-KVTSVDKANVLASSK-LWRKIADEVASRHPDITLEHLYVDAAAMLMIQRPTTFD-- 231 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTAL 1021 V+V NL+GDILSD + + G LG+ PS + + S++E +HGSAPDIA + +ANP ++ Sbjct: 232 VIVTENLFGDILSDEASVITGSLGMLPSASHAENGPSLYEPIHGSAPDIANQNIANPMSM 291 Query: 1022 LLS-SIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 + S S+M+ Q LFE A+ I AA +T+ G +T DLGG + T ++ V+K + Sbjct: 292 ISSVSMMLRQSFSLFEEADAIDAATARTMQAG-FLTADLGGNTSTTDFTNEVLKQI 346
>Q2G4X5:LEU3_NOVAD 3-isopropylmalate dehydrogenase - Novosphingobium aromaticivorans| (strain DSM 12444) Length = 352 Score = 144 bits (363), Expect = 9e-34 Identities = 111/355 (31%), Positives = 186/355 (52%), Gaps = 25/355 (7%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANV-PIKWESIDVTPSLNADGKTVIPDESIASIKRNY 373 ++++ GDGIGPE+ + + A + I+ + V + +P E++ + + Sbjct: 3 IAVLPGDGIGPEVTREAVRVIEALGLGDIEMKEAPVGGAAYKAYGHPLPPETLEIARLSD 62 Query: 374 VALKGPLATPIGKG---HVSLN---LTLRRTFNLFANVRPCKSIQGYKT-------PYDN 514 L G + P H+ L LR+ LFAN+RP + +G + Sbjct: 63 GILFGAVGDPDCDSLERHLRPEQAILGLRKALTLFANLRPARVFKGMEDFSALRPEVAGA 122 Query: 515 VDTVLIRENTEGEYSGIE--HVVVDGVVQSIKLITREASE--RVLRFAFQYAQDIGKPKV 682 +D +++RE Y G + +G + +++ SE R+ AF+ A K ++ Sbjct: 123 IDLLIVRELNGDVYFGEKGFRTAANGDREGYDVMSYSESEVRRIAHVAFRAAMG-RKKRL 181 Query: 683 RVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPN 862 V KA +++ S L+ ++ E+AK+YP + + +DNA +++V P N V+V N Sbjct: 182 CSVDKANVLETSQ-LWRDVMLEVAKDYPEVALEHMYVDNAAMQLVR--APGNFDVVVTGN 238 Query: 863 LYGDILSDMCAGLIGGLGLTPSGNIGDE------CSIFEAVHGSAPDIAGKGLANPTALL 1024 L+GDILSD + +G +GL S ++G+ ++E +HGSAPDIAGKGLANP A + Sbjct: 239 LFGDILSDQASMCVGSIGLLASASLGERETEYGTFGLYEPIHGSAPDIAGKGLANPMATI 298 Query: 1025 LSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 LS+ M+L+H +GL A++I+AA+ K LA+G + DLGG + T E AV+ L Sbjct: 299 LSAAMLLRHSLGLEVAADRIEAAVAKALADG-VLGRDLGGTAGTTEIGDAVLARL 352
>Q30RK2:LEU3_THIDN 3-isopropylmalate dehydrogenase - Thiomicrospira denitrificans| (strain ATCC 33889 / DSM 1351) Length = 355 Score = 144 bits (362), Expect = 1e-33 Identities = 109/327 (33%), Positives = 171/327 (52%), Gaps = 19/327 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI---AQSVKD-IYSAANVPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++LI+GDGIGPEI A V D + S ++ +E + +P E+I Sbjct: 4 YKIALIKGDGIGPEIIDEAVKVLDAVASCCDLEFSYEEALMGGCAYDITGDPLPQETINI 63 Query: 359 IKRNYVALKGPLA------TPIGKGHVSLNLTLRRTFNLFANVRPCK------SIQGYKT 502 + L G + P K S L R+ ++AN+RP + K Sbjct: 64 SLNSDAVLFGAIGGAKWDNLPREKRPESGLLRFRKELGVYANLRPANVFDELINASSLKA 123 Query: 503 PY-DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPK 679 VD +++RE G Y G + + + TRE R+ AF+ A K + Sbjct: 124 EVIKGVDLMVVRELIGGIYFGEPKGRDENRGWNTMVYTREEIVRIAHQAFKIAMSRSK-R 182 Query: 680 VRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMP 859 V + KA ++ +S L+ + E+AKEYP +E +DNA ++++ DP ++ V++ Sbjct: 183 VCSIDKANVLDVSQ-LWREVVIEVAKEYPEVELTHMYVDNAAMQLIRDPRQFD--VMLTG 239 Query: 860 NLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIM 1039 N++GDILSD + L G +GL PS ++G + ++E +HGSAPDIAG+G+ANP A +LS+ M Sbjct: 240 NIFGDILSDEASMLSGSIGLLPSASVGAKIGVYEPIHGSAPDIAGQGIANPIATILSASM 299 Query: 1040 MLQHMGLFEH--ANKIQAAIFKTLAEG 1114 ML++ L EH A+KI AA+ + L EG Sbjct: 300 MLRY-ALGEHGAADKIDAAVKRALKEG 325
>Q49Z13:LEU3_STAS1 3-isopropylmalate dehydrogenase - Staphylococcus saprophyticus subsp.| saprophyticus (strain ATCC 15305 / DSM 20229) Length = 346 Score = 144 bits (362), Expect = 1e-33 Identities = 113/351 (32%), Positives = 182/351 (51%), Gaps = 19/351 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWE----SIDVTP-SLNADGKTVIPDESIA 355 Y + + GDGIGPEI +I + +E S D +++ GK +PD ++ Sbjct: 3 YKIVALPGDGIGPEILNGSLEILQQLSKEFHFEYELESHDFGGIAIDNHGKP-LPDSTLN 61 Query: 356 SIKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQG--YKTPYD- 511 + K L G + P + L L +R+ LFAN+RP G + +P Sbjct: 62 ACKNADAILLGAVGGPKWTDPNNRPEQGL-LGIRKALGLFANIRPTTVTNGTSHLSPIKE 120 Query: 512 ----NVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPK 679 N D +L+RE T G Y G + + TR+ ER+ R F+ AQ K K Sbjct: 121 ERVANTDFILVRELTGGIYFGEPKQLSENDALDSLTYTRDEIERIARVGFELAQKRHK-K 179 Query: 680 VRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMP 859 + V K ++ S L+ N+ E+++ YP++E + L+D + ++T+P+ ++ V+V Sbjct: 180 LTSVDKENVLSSSK-LWRNVINEVSQSYPDVEVNHLLVDACAMHLITNPSQFD--VIVTE 236 Query: 860 NLYGDILSDMCAGLIGGLGLTPSGNIGDECS-IFEAVHGSAPDIAGKGLANPTALLLSSI 1036 NL+GDILSD + + G LGL+PS + ++ ++E +HGSAPDIA + +ANP +LLS Sbjct: 237 NLFGDILSDEASVIPGSLGLSPSASFSEQGPRLYEPIHGSAPDIANQDIANPFGMLLSVA 296 Query: 1037 MML-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 M L + + + A+K++ I++ + EGKT T DL G T E V +NL Sbjct: 297 MCLRESLNEDKAADKLENVIYQLIKEGKT-TRDLNGNYLTSEIFNYVKENL 346
>Q7MP78:LEU3_VIBVY 3-isopropylmalate dehydrogenase - Vibrio vulnificus (strain YJ016)| Length = 363 Score = 143 bits (360), Expect = 2e-33 Identities = 104/347 (29%), Positives = 180/347 (51%), Gaps = 26/347 (7%) Frame = +2 Query: 179 SDGKYTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDE 346 +D Y ++++ GDGIGPE+ + A + + E DV + +P Sbjct: 2 TDKTYKIAVLPGDGIGPEVMAQAHKVLDAIEKKHAIHFEREEHDVGGIAIDNHGCPLPQS 61 Query: 347 SIASIKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT 502 ++ + + + L G + P + H+ N L LR+ F LF N+RP + G + Sbjct: 62 TVTACEESDAVLFGSVGGPKWE-HLPPNDQPERGALLPLRKHFQLFCNLRPAQIHSGLEA 120 Query: 503 --------PYDNVDTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFA 646 D V++RE T G Y G E + ++ R ER+ + A Sbjct: 121 FSPLRADISGRGFDIVVVRELTGGIYFGQPKGREGEGANEKAYDTEIYHRFEIERIAKIA 180 Query: 647 FQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDP 826 F+ A+ + + KV + KA +++ S L+ + EIAK+YP++E +DNA ++++ DP Sbjct: 181 FESAR-LRRKKVCSIDKANVLQSSI-LWREVVEEIAKDYPDVELSHMYIDNATMQLIKDP 238 Query: 827 TPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAPDIAGKGL 1003 ++ V++ N++GDI+SD CA + G +G+ PS ++ + + ++E GSAPDIAGK + Sbjct: 239 AQFD--VMLCSNIFGDIISDECAMITGSMGMLPSASLNESKFGLYEPAGGSAPDIAGKNI 296 Query: 1004 ANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGG 1141 ANP A +LS+ +ML++ +G A I+ A+ + LA G+ +T DL G Sbjct: 297 ANPVAQILSAALMLRYSLGEEAAAQDIENAVSQALAAGE-LTADLAG 342
>Q9WZ26:LEU3_THEMA 3-isopropylmalate dehydrogenase - Thermotoga maritima| Length = 354 Score = 143 bits (360), Expect = 2e-33 Identities = 104/326 (31%), Positives = 167/326 (51%), Gaps = 20/326 (6%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNAD-----GKTVIPDESIASI 361 ++++ GDGIGPE+ + + V + D G+ + + + Sbjct: 3 IAVLPGDGIGPEVVREALKVLEVVEKKTGKTFEKVFGHIGGDAIDRFGEPLPEETKKICL 62 Query: 362 KRNYVALK---GPL---ATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY--------K 499 + + + L GP P + + L LR+ NL+AN+RP K + K Sbjct: 63 EADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSPLKEK 122 Query: 500 TPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPK 679 VD V +RE + G Y G + + + R+ ER+ R AF+ A++ K K Sbjct: 123 VIGSGVDLVTVRELSYGVYYGQPRGLDEEKGFDTMIYDRKTVERIARTAFEIAKNRRK-K 181 Query: 680 VRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMP 859 V V KA ++ S L+ + E+A+EYP++E +DNA ++++ P+ ++ V++ Sbjct: 182 VTSVDKANVL-YSSMLWRKVVNEVAREYPDVELTHIYVDNAAMQLILKPSQFD--VILTT 238 Query: 860 NLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIM 1039 N++GDILSD A L G LGL PS + GD+ +++E GSAPDIAGK +ANP A +LS M Sbjct: 239 NMFGDILSDESAALPGSLGLLPSASFGDK-NLYEPAGGSAPDIAGKNIANPIAQILSLAM 297 Query: 1040 MLQH-MGLFEHANKIQAAIFKTLAEG 1114 ML+H G+ E A KI+ A+ + EG Sbjct: 298 MLEHSFGMVEEARKIERAVELVIEEG 323
>Q9RTH9:LEU3_DEIRA 3-isopropylmalate dehydrogenase - Deinococcus radiodurans| Length = 352 Score = 143 bits (360), Expect = 2e-33 Identities = 110/353 (31%), Positives = 180/353 (50%), Gaps = 23/353 (6%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYS--AANVPIKWESIDVTPSLNADGKTVIPDESIASIKRN 370 V + GDGIGPE+ + + A +V ++ +I + +A G+ P + ++K Sbjct: 4 VITLPGDGIGPEVTAAAVQVLREVAPDVTVEEHAIG-GGAYDAHGEP-FPTSTRDALKEA 61 Query: 371 YVALKGPLATPIGKGHVSL-------------NLTLRRTFNLFANVRPCKSIQGYK--TP 505 L G +G H S L LR+ +AN+RP + G + +P Sbjct: 62 DAVLLGT----VGGAHDSAWNQLPRHLRPESGLLALRKALGCYANLRPVRVQPGLEHLSP 117 Query: 506 YD-----NVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIG 670 VD +++RE G Y + + + T ERV + AF +A + Sbjct: 118 LKAELARGVDILIVRELLGGIYFDQDRKIEGDTAYNTMRYTTSEVERVAKVAF-WAAEQR 176 Query: 671 KPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVL 850 K +V V KA ++++S+ ++ ++Y +I + E +D+ + +V DP+ Y+ V+ Sbjct: 177 KGRVTSVDKANVLEVSELWRRDVQALRDRDYRSIHLNHEYVDSVAMLIVADPSRYD--VI 234 Query: 851 VMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLS 1030 + NL+GDILSD+ A + G LGL PS ++GD +FE +HGSAPDIAG+G+ANP A ++S Sbjct: 235 LTENLFGDILSDLAAVIPGSLGLMPSASLGDGAGLFEPIHGSAPDIAGQGVANPAAAIMS 294 Query: 1031 SIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 M+L+H + E AN++ A+ L E T DLGG + T + AV+K L Sbjct: 295 VGMLLRHGLERSEAANQVDRAVALALREQP--TRDLGGSADTQTFTRAVLKAL 345
>Q87SS8:LEU3_VIBPA 3-isopropylmalate dehydrogenase - Vibrio parahaemolyticus| Length = 363 Score = 142 bits (359), Expect = 3e-33 Identities = 103/345 (29%), Positives = 181/345 (52%), Gaps = 26/345 (7%) Frame = +2 Query: 179 SDGKYTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDE 346 +D Y ++++ GDGIGPE+ + A + + E DV + +P+ Sbjct: 2 TDKSYKIAVLPGDGIGPEVMAQAHKVLDAIEQKHGISFEREEHDVGGIAIDNHGCPLPES 61 Query: 347 SIASIKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT 502 ++ + + + L G + P + H+ N L LR+ F LF N+RP + G + Sbjct: 62 TVTACEESDAVLFGSVGGPKWE-HLPPNDQPERGALLPLRKHFQLFCNLRPAQIHAGLEA 120 Query: 503 --------PYDNVDTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFA 646 D V++RE T G Y G E + ++ R ER+ + A Sbjct: 121 FSPLRADISGRGFDIVVVRELTGGIYFGQPKGREGEGANEKAFDTEVYHRYEIERIAKIA 180 Query: 647 FQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDP 826 F+ A+ + + KV + KA +++ S L+ + EIAK+YP++E +DNA ++++ DP Sbjct: 181 FESAR-LRRKKVCSIDKANVLQSSI-LWREVVEEIAKDYPDVELSHMYIDNATMQLIKDP 238 Query: 827 TPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAPDIAGKGL 1003 ++ V++ N++GDI+SD CA + G +G+ PS ++ + + ++E GSAPDIAGK + Sbjct: 239 AQFD--VMLCSNIFGDIISDECAMITGSMGMLPSASLNESKFGLYEPAGGSAPDIAGKNI 296 Query: 1004 ANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 ANP A +LS+ +ML++ +G A I++A+ K L+ G+ +T DL Sbjct: 297 ANPVAQILSAALMLRYSLGEEAAAQDIESAVSKALSAGE-LTADL 340
>Q2IJK7:LEU3_ANADE 3-isopropylmalate dehydrogenase - Anaeromyxobacter dehalogenans| (strain 2CP-C) Length = 353 Score = 142 bits (359), Expect = 3e-33 Identities = 117/354 (33%), Positives = 187/354 (52%), Gaps = 24/354 (6%) Frame = +2 Query: 197 VSLIEGDGIGPEI-AQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIASI 361 + ++ GDGIGPE+ A++V+ + + A + E + S++A G + P E +A Sbjct: 5 IVVLPGDGIGPEVTAEAVRVLEAVARRGGHALSFTERLMGGCSIDAHGTALTP-EVLADC 63 Query: 362 KRNYVALKGPLA-----TPIGKGHVSLNLT-LRRTFNLFANVRPCK-------SIQGYKT 502 + L G + P K L LR+ +FAN+RP + S Sbjct: 64 QAADAVLLGAVGGPKWDDPRAKVRPEQGLLGLRKGLGVFANLRPVRVHPSLLDSSPLRPE 123 Query: 503 PYDNVDTVLIRENTEGEYSGIE--HVVVDGVVQSIKLITREASE--RVLRFAFQYAQDIG 670 VD ++IRE T G Y G V DG +++ + + E RV+ AF+ A+ Sbjct: 124 KLRGVDIMVIRELTGGLYFGQPKGRDVKDGHARAVDTLEYQDFEVRRVVELAFRIAKG-R 182 Query: 671 KPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVL 850 K KV V KA +++ S L+ L I + P++ D L+D A +++VT P + V+ Sbjct: 183 KKKVTSVDKANVLE-SSRLWRELATAIGQANPDVALDHMLVDTAAMRLVTSPATLD--VV 239 Query: 851 VMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTALLL 1027 V N++GDIL+D + L G +G+ PS +IG++ ++E +HGSAPDIAGKG+ANP +L Sbjct: 240 VTENMFGDILTDEASVLAGSMGMLPSASIGEQGPGLYEPIHGSAPDIAGKGIANPVGTVL 299 Query: 1028 SSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 S+ ++L+H +GL A I+ A+ +T+ +G T DLGGK T A ++K L Sbjct: 300 SAALLLRHSLGLEPEAAAIERAVDQTITDG-CRTADLGGKLSTRAMADEILKRL 352
>Q8DEE0:LEU3_VIBVU 3-isopropylmalate dehydrogenase - Vibrio vulnificus| Length = 363 Score = 142 bits (358), Expect = 3e-33 Identities = 103/347 (29%), Positives = 180/347 (51%), Gaps = 26/347 (7%) Frame = +2 Query: 179 SDGKYTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDE 346 +D Y ++++ GDGIGPE+ + A + + E DV + +P Sbjct: 2 TDKTYKIAVLPGDGIGPEVMAQAHKVLDAIEKKHAIHFEREEHDVGGIAIDNHGCPLPQS 61 Query: 347 SIASIKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT 502 ++ + + + L G + P + H+ N L LR+ F LF N+RP + G + Sbjct: 62 TVTACEESDAVLFGSVGGPKWE-HLPPNDQPERGALLPLRKHFQLFCNLRPAQIHSGLEA 120 Query: 503 --------PYDNVDTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFA 646 D V++RE T G Y G E + ++ R ER+ + A Sbjct: 121 FSPLRADISGRGFDIVVVRELTGGIYFGQPKGREGEGANEKAYDTEIYHRFEIERIAKIA 180 Query: 647 FQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDP 826 F+ A+ + + KV + KA +++ S L+ + E+AK+YP++E +DNA ++++ DP Sbjct: 181 FESAR-LRRKKVCSIDKANVLQSSI-LWREVVEELAKDYPDVELSHMYIDNATMQLIKDP 238 Query: 827 TPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAPDIAGKGL 1003 ++ V++ N++GDI+SD CA + G +G+ PS ++ + + ++E GSAPDIAGK + Sbjct: 239 AQFD--VMLCSNIFGDIISDECAMITGSMGMLPSASLNESKFGLYEPAGGSAPDIAGKNI 296 Query: 1004 ANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGG 1141 ANP A +LS+ +ML++ +G A I+ A+ + LA G+ +T DL G Sbjct: 297 ANPVAQILSAALMLRYSLGEEAAAQDIENAVSQALAAGE-LTADLAG 342
>Q9KP82:LEU3_VIBCH 3-isopropylmalate dehydrogenase - Vibrio cholerae| Length = 363 Score = 142 bits (358), Expect = 3e-33 Identities = 107/347 (30%), Positives = 178/347 (51%), Gaps = 26/347 (7%) Frame = +2 Query: 179 SDGKYTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDE 346 +D Y ++++ GDGIGPE+ + A + E DV + +P+ Sbjct: 2 TDRDYKIAVLPGDGIGPEVMAQAHKVLDAIEQKHGIRFSREEHDVGGIAIDNHGCPLPES 61 Query: 347 SIASIKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT 502 ++ + + L G + P + H+ N L LR+ F LF N+RP + QG + Sbjct: 62 TLRACEEADAVLFGSVGGPKWE-HLPPNEQPERGALLPLRKHFQLFCNLRPAQIHQGLEA 120 Query: 503 --------PYDNVDTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFA 646 D V++RE T G Y G E ++ R ER+ R A Sbjct: 121 FSPLRADISARGFDIVVVRELTGGIYFGQPKGREGEGAHEKAFDTEVYHRFEIERIARIA 180 Query: 647 FQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDP 826 F+ A+ + + KV + KA +++ S L+ + EIAKEYP++ +DNA ++++ DP Sbjct: 181 FESAR-LRRKKVCSIDKANVLQSSI-LWREVVSEIAKEYPDVSLSHMYIDNATMQLIKDP 238 Query: 827 TPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAPDIAGKGL 1003 ++ V++ N++GDILSD CA + G +G+ PS ++ + + ++E GSAPDIAGK + Sbjct: 239 AQFD--VMLCSNIFGDILSDECAMITGSMGMLPSASMNESKFGLYEPAGGSAPDIAGKNI 296 Query: 1004 ANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGG 1141 ANP A +LS+ +ML++ +G A I+ A+ + LA G+ +T DL G Sbjct: 297 ANPVAQILSAALMLRYSLGEEAAARDIENAVSQALAAGE-LTADLAG 342
>Q1IZK2:LEU3_DEIGD 3-isopropylmalate dehydrogenase - Deinococcus geothermalis (strain| DSM 11300) Length = 351 Score = 142 bits (358), Expect = 3e-33 Identities = 110/351 (31%), Positives = 181/351 (51%), Gaps = 24/351 (6%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYS--AANVPIKWESI-------------DVTPSLNADGKT 331 V + GDGIGPE+ + ++ A +V I+ +I T D Sbjct: 4 VVTLPGDGIGPEVTAAAAEVLREVAPDVHIEEHAIGGAAYEQFGDPFPQRTRDALGDADA 63 Query: 332 VIPDESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYK--TP 505 V+ + + +L PL G L LRR +AN+RP + + G + +P Sbjct: 64 VLLGTVGGAQNSPWNSLPRPLRPESGL------LALRRALGCYANLRPVRVLPGLEHLSP 117 Query: 506 YD-----NVDTVLIRENTEGEY-SGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDI 667 VD +++RE G Y G + D +++ T E ERV R AF +A + Sbjct: 118 LKPELARGVDILIVRELLGGIYFDGDRKIEGDTAYNTMRYTTPEV-ERVARVAF-WAAEQ 175 Query: 668 GKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKV 847 + +V V KA ++++S+ ++ +EY N+ + E +D+ + +V +P+ Y+ V Sbjct: 176 RRGRVTSVDKANVLEVSELWRRDVQALRDREYRNVHLNHEYVDSVAMLIVANPSRYD--V 233 Query: 848 LVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLL 1027 ++ NL+GDILSD+ A + G LGL PS ++GD +FE +HGSAPDIAG+G+ANP A ++ Sbjct: 234 ILTENLFGDILSDLAAVIPGSLGLMPSASLGDGPGLFEPIHGSAPDIAGQGIANPAAAIM 293 Query: 1028 SSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVI 1177 S M+L+H + + AN+++ A+ L E T DLGG++ T + AV+ Sbjct: 294 SVAMLLRHGLERPQVANQVERAVALALREHP--TRDLGGQADTRTFTHAVL 342
>Q9PLW0:LEU3_CAMJE 3-isopropylmalate dehydrogenase - Campylobacter jejuni| Length = 358 Score = 142 bits (358), Expect = 3e-33 Identities = 114/342 (33%), Positives = 185/342 (54%), Gaps = 23/342 (6%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDI--YSAANVPIKWESIDVT---PSLNADGKTVIPDESIA 355 Y V+++ GDGIGP + + I + A +E + S++A G + DE++ Sbjct: 4 YKVAVLAGDGIGPLVMKEALKILTFIAQKYNFSFEFNEAKIGGASIDAYG-VALSDETLK 62 Query: 356 SIKRNYVALKGPLATPIGKG--------HVSLNLTLRRTFNLFANVRPCKSIQG--YKTP 505 +++ L G + P SL L LR+ FNLFAN+RPCK + + +P Sbjct: 63 LCEQSDAILFGSVGGPKWDNLPIDQRPERASL-LPLRKHFNLFANLRPCKIYESLTHASP 121 Query: 506 YDN------VDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDI 667 N VD + +RE T G Y G + + + + ++ T++ ER+ R AF+ A+ I Sbjct: 122 LKNEIIQKGVDILCVRELTGGIYFGKQDLGKESAYDT-EIYTKKEIERIARIAFESAR-I 179 Query: 668 GKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKV 847 K KV ++ KA ++ S L+ + +AK+Y +I + +DNA +++V +P+ ++ V Sbjct: 180 RKKKVHLIDKANVLASSI-LWREVVANVAKDYQDINLEYMYVDNAAMQIVKNPSIFD--V 236 Query: 848 LVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTALL 1024 ++ NL+GDILSD A + G LGL S ++ D+ ++E GSAPDIA +ANP A + Sbjct: 237 MLCSNLFGDILSDELAAINGSLGLLSSASLNDKGFGLYEPAGGSAPDIAHLNIANPIAQI 296 Query: 1025 LSSIMMLQHMGLFEH-ANKIQAAIFKTLAEGKTITGDLGGKS 1147 LS+ +ML++ E A I+ AI LA+GK +T DL KS Sbjct: 297 LSAALMLKYSFKEEQAAQDIENAISLALAQGK-MTKDLNAKS 337
>Q5E857:LEU3_VIBF1 3-isopropylmalate dehydrogenase - Vibrio fischeri (strain ATCC 700601| / ES114) Length = 363 Score = 142 bits (357), Expect = 4e-33 Identities = 102/343 (29%), Positives = 177/343 (51%), Gaps = 26/343 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ + + A + E DV + +P+ ++ Sbjct: 6 YKIAVLPGDGIGPEVMEQAHKVLDAIEKKHAISFSREQHDVGGIAIDNHGCPLPESTVKG 65 Query: 359 IKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT---- 502 + + L G + P + H+ N L LR+ F LF N+RP + +G + Sbjct: 66 CEESDAVLFGSVGGPKWE-HLPPNDQPERGALLPLRKHFQLFCNLRPAQIHKGLENFSPL 124 Query: 503 ----PYDNVDTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFAFQYA 658 D V++RE T G Y G E ++ R ER+ + AF+ A Sbjct: 125 RADISERGFDIVVVRELTGGIYFGQPKGREGEGPQEKAYDTEIYHRYEIERIAKIAFESA 184 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 + + V + KA +++ S L+ + E+AK YP++ + +DNA ++++ DP+ ++ Sbjct: 185 R-LRNKNVYSIDKANVLQSSI-LWREVVEEVAKGYPDVTLNHMYIDNATMQLIKDPSQFD 242 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPT 1015 V++ N++GDI+SD CA + G +G+ PS ++ + ++E GSAPDIAGK +ANP Sbjct: 243 --VMLCSNIFGDIISDECAMITGSMGMLPSASLNESNFGLYEPAGGSAPDIAGKNIANPV 300 Query: 1016 ALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGG 1141 A +LS+ +ML++ +G E A I+AA+ K L+ G+ +T DL G Sbjct: 301 AQILSAALMLRYSLGEEEAAQSIEAAVSKALSAGE-LTADLAG 342
>Q3IJS3:LEU3_PSEHT 3-isopropylmalate dehydrogenase - Pseudoalteromonas haloplanktis| (strain TAC 125) Length = 358 Score = 142 bits (357), Expect = 4e-33 Identities = 112/364 (30%), Positives = 191/364 (52%), Gaps = 28/364 (7%) Frame = +2 Query: 179 SDGKYTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVT-PSLNADGKTVIPD 343 S Y+V+++ GDGIGPEI + + + A + + E + +++ GK +P Sbjct: 2 SKTNYSVAVLAGDGIGPEIMAAAEQVLDAVSNKFGFTLNREHHAIGGAAIDKHGKA-LPQ 60 Query: 344 ESIASIKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYK 499 ++ + + L G + P + H+ + L LR+ F LF N+RP + + Sbjct: 61 STVTACENADAILFGAVGGPKWE-HLPPDEQPERGSLLPLRKHFGLFCNLRPAQLLPALS 119 Query: 500 TPY--------DNVDTVLIRENTEGEYSGIEHVVVDGVVQSI---KLITREASERVLRFA 646 T D + +RE T G Y G + +G +S + +R+ ER+ RFA Sbjct: 120 TASPLRADISEQGFDILCVRELTGGIYFGEKGRSGEGENESAFDTQRYSRKEIERIARFA 179 Query: 647 FQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDP 826 F+ A+ + V V KA ++ S L+ + E++K+YP ++ D +DNA +++V P Sbjct: 180 FEAAK-LRSSHVTSVDKANVLA-SSVLWREVVTEVSKDYPEVKLDYIYVDNAAMQLVKQP 237 Query: 827 TPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGL 1003 + ++ VL+ NL+GDILSD CA + G +GL PS ++ ++E GSAPDIAGKG+ Sbjct: 238 SQFD--VLLCDNLFGDILSDECAMITGSMGLLPSASLNQSGFGLYEPAGGSAPDIAGKGV 295 Query: 1004 ANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL--GGKSKTHEYAAAV 1174 ANP A +LS+ +ML++ +G E A I+ A+ + +A G T D+ T++ AAA+ Sbjct: 296 ANPIAQILSAALMLRYSLGQDEAARTIEKAVAEAVAAG-VGTPDIFPNAGYTTNDVAAAI 354 Query: 1175 IKNL 1186 + + Sbjct: 355 VARI 358
>Q4L7U1:LEU3_STAHJ 3-isopropylmalate dehydrogenase - Staphylococcus haemolyticus (strain| JCSC1435) Length = 346 Score = 141 bits (356), Expect = 6e-33 Identities = 107/350 (30%), Positives = 180/350 (51%), Gaps = 19/350 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWE----SIDVTPSLNADGKTVIPDESIAS 358 Y + + GDGIGPEI ++ + K++ S D + +PD+++ + Sbjct: 3 YNIVALPGDGIGPEILSGTLELLELISKKYKFDYQLTSYDFGGAAIDSHGVPLPDDTLNA 62 Query: 359 IKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY-------KT 502 K L G + P + L L LR++ LFAN+RP K +G ++ Sbjct: 63 CKNADAILLGAVGGPQWTDPNNRPEQGL-LALRKSLGLFANIRPTKVTEGTSHFSPIKES 121 Query: 503 PYDNVDTVLIRENTEGEYSGI-EHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPK 679 D +++RE T G Y G H+ + S+ T++ ER+ AF+ A K K Sbjct: 122 RVKGTDFIIVRELTSGLYFGEPRHIDNQSALDSLTY-TKKEIERIAMVAFELASQ-RKKK 179 Query: 680 VRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMP 859 + V K ++ S L+ EI+ E+P+++ + L+D +++++ PT ++ V+V Sbjct: 180 LTSVDKENVLATSK-LWRKTINEISHEFPDVKVNHLLVDACSMQLISQPTNFD--VIVTE 236 Query: 860 NLYGDILSDMCAGLIGGLGLTPSGNIGDECS-IFEAVHGSAPDIAGKGLANPTALLLSSI 1036 NL+GDILSD + + G LGL+PS + E ++E +HGSAPDIA + LANP ++LS Sbjct: 237 NLFGDILSDEASTIPGSLGLSPSASFSLEGPRLYEPIHGSAPDIANQNLANPFGMILSLA 296 Query: 1037 MMLQHMGLFEH-ANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKN 1183 M L+ FE A++++ A+++ + +GKT T DL G T + + KN Sbjct: 297 MCLRESFNFEDAASELEQAVYQLIKDGKT-TKDLNGHYTTSDIFNELKKN 345
>Q3B595:LEU3_PELLD 3-isopropylmalate dehydrogenase - Pelodictyon luteolum (strain DSM| 273) (Chlorobium luteolum (strain DSM 273)) Length = 353 Score = 141 bits (356), Expect = 6e-33 Identities = 111/355 (31%), Positives = 179/355 (50%), Gaps = 23/355 (6%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQS----VKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y + I GDGIGPE+ ++ I I+ E + +++ DE++ + Sbjct: 2 YKIVSIPGDGIGPEVVAGALAVIRQITKKHGFEIQVEEHPFGGASYDLHGSMLTDETLNA 61 Query: 359 IKRNYVALKGPLATPIG-------KGHVSLNLTLRRTFNLFANVRPCKS----IQGYKTP 505 + L G + P K +L L +RR LFAN+RP K + Sbjct: 62 CRDCDAVLLGAVGGPKWENLPHEHKPEAAL-LKIRRELGLFANLRPAKVYDALVDASSLK 120 Query: 506 YDNV---DTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 D V D ++ RE T G Y G + + + + ER+ R AF+ AQ G Sbjct: 121 ADVVRGTDFMVFRELTGGIYFGEPRGFDEKRGWNTMVYEKHEVERIARLAFEAAQKRGSK 180 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 +V + KA ++++S + N + +++P++E +DNA +++V +P ++ V+V Sbjct: 181 RVMSIDKANVLEVSQ-FWRNEVHRVHRDFPDVELSDMYVDNAAMQIVRNPKQFD--VIVT 237 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSI 1036 NL+GDILSD+ + G LG+ PS +IG +++E +HGSAPDIAGK +ANP A + S Sbjct: 238 GNLFGDILSDIAGMITGSLGMLPSASIGRVHALYEPIHGSAPDIAGKNIANPIATIASVA 297 Query: 1037 MMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL---GGKS-KTHEYAAAVIKNL 1186 MM +H + + +N+I AAI L+EG T D+ G KS T E +I++L Sbjct: 298 MMFEHSFCMADISNEIHAAIEGALSEGLR-TADIAAPGQKSVSTTEMTEGIIRHL 351
>Q5KWJ4:LEU3_GEOKA 3-isopropylmalate dehydrogenase - Geobacillus kaustophilus| Length = 371 Score = 141 bits (355), Expect = 7e-33 Identities = 105/333 (31%), Positives = 175/333 (52%), Gaps = 23/333 (6%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANV----PIKWESIDVTPSLNADGKTVIPDESI 352 G Y ++++ GDGIG E+ ++ A + +E + + + T +P+E++ Sbjct: 2 GNYRIAVLPGDGIGKEVTSGAVEVLKAVGIRFGHEFTFEYGLIGGAAIDEAGTPLPEETL 61 Query: 353 ASIKRNYVALKGPLATPI---GKGHVSLN---LTLRRTFNLFANVRP--CKSIQGYKTPY 508 + + L G + P H+ L +R+ +L+AN+RP C +P Sbjct: 62 RLCRESDAVLLGAVGGPKWDDNPPHLRPEKGLLAIRKQLDLYANLRPVVCYDSLVSASPL 121 Query: 509 -----DNVDTVLIRENTEGEYSGIE--HVVVDGVVQSIK--LITREASERVLRFAFQYAQ 661 VD V++RE T G Y G VV +G +++ L +E ER++R AF A+ Sbjct: 122 KPDLVQGVDFVIVRELTGGIYFGQPSGRVVENGEEKAVDTLLYKKEEIERIVRMAFILAR 181 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 K KV V KA ++ S L+ + E+AK++P++ + L+DNA ++++ P ++ Sbjct: 182 G-RKKKVTSVDKANVLS-SSRLWREVAEEVAKQFPDVTLEHMLVDNAAMQLIRAPKQFD- 238 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTA 1018 V+V N++GDILSD + L G LG+ PS ++ S++E VHGSAPDIAG ANP A Sbjct: 239 -VIVTENMFGDILSDEASMLSGSLGMLPSASLSASGPSLYEPVHGSAPDIAGMNKANPIA 297 Query: 1019 LLLSSIMMLQ-HMGLFEHANKIQAAIFKTLAEG 1114 +LS+ MML+ GL A ++ A+ + L +G Sbjct: 298 AILSAAMMLRLSFGLTAEAEAVEHAVRQALDQG 330
>O31292:LEU3_BUCTS 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp. Thelaxes| suberi Length = 364 Score = 141 bits (355), Expect = 7e-33 Identities = 101/311 (32%), Positives = 166/311 (53%), Gaps = 24/311 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTP-SLNADGKTVIPDESIA 355 Y ++++ GDGIGPEI Q I + +K D+ S++ G T + E+I Sbjct: 6 YKIAVLPGDGIGPEIIQEAYKIIDVLQKKFSFNVKMHEYDIGGISIDKHG-TALTQETIE 64 Query: 356 SIKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYK--TPY 508 + + L G + I K + L LR+ FNLFAN+RPCK Q +P Sbjct: 65 GCENSDAILFGSVGGSKWDHLPEIEKPEKAGLLKLRKHFNLFANIRPCKLSQHLLDISPL 124 Query: 509 DN------VDTVLIRENTEGEYSGIEHVVV---DGVVQSIKLITREASERVLRFAFQYAQ 661 N +D + IRE T G Y G + + D ++ R +R+ + AFQ AQ Sbjct: 125 KNSIIKKGIDLICIRELTGGIYFGKSNKITNIDDPYAFDTEIYFRSEIKRIAKIAFQIAQ 184 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 K K+ + KA ++K S L+ + ++A ++PN++ + +DNA ++++ +P+ ++ Sbjct: 185 S-RKKKIVSIDKANVLKSSI-LWRDTVNKMAYKFPNVKLEHMYIDNATMELIKNPSSFD- 241 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTA 1018 V++ NL+GDI+SD CA +IG +GL PS ++ ++E GSAP+IAGK +ANP A Sbjct: 242 -VILCSNLFGDIISDECAAIIGSIGLLPSASLNKSGFGLYEPAGGSAPNIAGKTIANPIA 300 Query: 1019 LLLSSIMMLQH 1051 +LS M+L++ Sbjct: 301 QILSLSMLLKY 311
>Q9EVH5:LEU3_BUCUE 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Uroleucon erigeronensis Length = 364 Score = 140 bits (354), Expect = 1e-32 Identities = 110/363 (30%), Positives = 182/363 (50%), Gaps = 38/363 (10%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDESIA 355 KY ++++ GDGIGPE+ Q I + +P++ + ++ G I E IA Sbjct: 4 KYRIAVLPGDGIGPEVMQEAYKILNILKDHFLLPLEMKEFNI-------GGIAIDQEGIA 56 Query: 356 SIKRNYVALKGPLATPIGK------GHVSLN--------LTLRRTFNLFANVRPCKSIQG 493 K + + A G ++S++ L LR+ FNLF+N+RP K Sbjct: 57 LPKNTLLGCENSDAILFGSVGGKKWDYLSIDKRPERAALLPLRKHFNLFSNLRPAKLYAD 116 Query: 494 --YKTPY------DNVDTVLIRENTEGEYSG----------IEHVVVDGVVQSIKLITRE 619 Y +P D D + +RE T G Y G IE+ V ++ Sbjct: 117 LKYLSPLRSNIIKDGFDILCVRELTGGIYFGKPNGHSKKNDIEYAFDTEVYYDYEI---- 172 Query: 620 ASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDN 799 R+ AFQ A++ K KV + K+ ++K S L+ + +I+K YP++ +DN Sbjct: 173 --SRIAHLAFQLARN-RKKKVCSLDKSNVLKSSI-LWKEIVEKISKNYPDVHLSHLYIDN 228 Query: 800 ACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGS 976 A ++++ DP+ ++ V++ NL+GDI+SD CA + G +G+ PS ++ ++ ++E GS Sbjct: 229 AIMQIIKDPSQFD--VILCSNLFGDIVSDECAAITGSIGMLPSASLNEKNFGLYEPAGGS 286 Query: 977 APDIAGKGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 APDIAGK +ANP A +LS M+++H M L + A+KI ++ L +G T D+ S Sbjct: 287 APDIAGKNIANPIAQILSVSMLVRHGMNLKKIADKIDESVVSVLKQGYR-TADISNNS-- 343 Query: 1154 HEY 1162 H Y Sbjct: 344 HNY 346
>Q9K8E9:LEU3_BACHD 3-isopropylmalate dehydrogenase - Bacillus halodurans| Length = 363 Score = 140 bits (352), Expect = 2e-32 Identities = 107/330 (32%), Positives = 172/330 (52%), Gaps = 24/330 (7%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 ++++ GDGIGPE+ + ++ A ++ + + T +P+E++ + Sbjct: 5 IAVLPGDGIGPEVTDAAIEVLQAVADRFGHTFSYKKALLGGCAIDEVGTPLPEETLDVCR 64 Query: 365 RNYVALKGPLATPIGK---GHVSLN---LTLRRTFNLFANVRPCK---SIQGYKT----P 505 L G + P GH+ L LR+ NLFAN+RP S+ T Sbjct: 65 HADGILLGAVGGPKWDTLPGHLRPEKGLLGLRKGLNLFANLRPVTVYDSLADASTLKNDV 124 Query: 506 YDNVDTVLIRENTEGEYSGIEHV-----VVDGVVQSIKLITREASERVLRFAFQYAQDIG 670 D VD +++RE T G Y G + VV ++ L TR R++R AF+ A + Sbjct: 125 IDGVDLLIVRELTGGLYFGEPRERRGEGETEEVVDTL-LYTRGEMRRIIRKAFELAM-VR 182 Query: 671 KPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVL 850 V V KA +++ S ++ + E+A+E+P + + L+DNA ++++ P ++ VL Sbjct: 183 NKHVTSVDKANVLE-SSRMWREVANEVAQEFPEVTLEHMLVDNAAMQLIRRPKQFD--VL 239 Query: 851 VMPNLYGDILSDMCAGLIGGLGLTPSGNI-GDECSIFEAVHGSAPDIAGKGLANPTALLL 1027 V NL+GDILSD + + G LG+ PS ++ D ++E +HGSAPDIAGKG+ANP A + Sbjct: 240 VTENLFGDILSDEASMVTGSLGMLPSASLTSDGPGLYEPIHGSAPDIAGKGVANPLATIA 299 Query: 1028 SSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 S MML++ GL E A I+ AI L +G Sbjct: 300 SCAMMLKYSFGLHEEAKTIEDAIEAVLKQG 329
>Q5NPQ9:LEU3_ZYMMO 3-isopropylmalate dehydrogenase - Zymomonas mobilis| Length = 349 Score = 139 bits (350), Expect = 3e-32 Identities = 112/352 (31%), Positives = 184/352 (52%), Gaps = 22/352 (6%) Frame = +2 Query: 197 VSLIEGDGIGPEI-AQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNY 373 ++L+ GDGIGPEI A++VK + + I+++ + + + +P+E++ K + Sbjct: 3 IALLAGDGIGPEITAEAVKILKAVVGQEIEFDEALIGGAAWKVTGSPLPEETLKLCKNSD 62 Query: 374 VALKGPLATPIGKGHVSLNLT-------LRRTFNLFANVRPCK---SIQGYKTPYDNV-- 517 L G + P H+ L LR+ +LFAN+RP + +Q +N+ Sbjct: 63 AILFGSVGDP-ECDHLERALRPEQAILGLRKELDLFANLRPARLFPELQAESPLKENIVT 121 Query: 518 --DTVLIRENTEGEYSGIEHVV-VDGVVQSIKLITREASE----RVLRFAFQYAQDIGKP 676 D +++RE T Y G D + T +E R+ R F+ A+ Sbjct: 122 GTDLMIVRELTGDVYFGTPRGQRKDDQNRREGFDTMRYNEDEVKRIARIGFETARS-RSG 180 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 + + K+ +++ S L+ + EIA+EYP++E +DNA +++V P ++ V+V Sbjct: 181 NLCSIDKSNVLETSQ-LWRTVVLEIAQEYPDVELSHMYVDNAAMQLVRAPDQFD--VIVT 237 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIGDECS-IFEAVHGSAPDIAGKGLANPTALLLSS 1033 NL+GDILSD+ + +G +GL PS ++ E ++E +HGSAPDIAG G ANP A +LS Sbjct: 238 GNLFGDILSDLASACVGSIGLLPSASLNSEGKGLYEPIHGSAPDIAGLGKANPLATILSG 297 Query: 1034 IMMLQHMGLFE-HANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 MML++ E A++I+ A+ L +G T DLGGK T E AV+ L Sbjct: 298 AMMLRYSLKREADADRIEKAVSTALEKGAR-TADLGGKMTTSEMGNAVLAAL 348
>Q7N128:LEU3_PHOLL 3-isopropylmalate dehydrogenase - Photorhabdus luminescens subsp.| laumondii Length = 363 Score = 139 bits (350), Expect = 3e-32 Identities = 108/345 (31%), Positives = 176/345 (51%), Gaps = 25/345 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ I A N+ I DV +P +++A Sbjct: 5 YHIAVLPGDGIGPEVMAQAYKILDAIRKRFNICITTSEYDVGGIAIDRHGCSLPAKTVAG 64 Query: 359 IKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT--PYD 511 ++ L G + P + L LR+ F LF+N+RP + G + P Sbjct: 65 CEQADAILFGSVGGPKWEHLPPAEQPERGALLPLRKHFKLFSNLRPARLYAGLEVFCPLR 124 Query: 512 N------VDTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQ 661 N D + +RE T G Y G E ++ R ER+ R AF+ A+ Sbjct: 125 NDIAAKGFDILCVRELTGGIYFGQPKGREGQGKYERAFDTEVYHRFEIERIARIAFESAR 184 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 KV + KA +++ S L+ + EIAK YP++E + +DNA ++++ DP+ ++ Sbjct: 185 KRSN-KVTSIDKANVLQ-SSVLWREVVTEIAKAYPDVEINHMYIDNATMQLIKDPSQFD- 241 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTA 1018 V++ N++GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGKG+ANP A Sbjct: 242 -VMLCSNIFGDILSDECAMITGSMGMLPSASLNEKGFGLYEPAGGSAPDIAGKGIANPIA 300 Query: 1019 LLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSK 1150 +LS+ ++L++ +G + AN I+ A+ L +G T DL G K Sbjct: 301 QILSAALLLRYSLGHNDAANAIEQAVNYALEQGYRTT-DLAGNGK 344
>Q5HMF8:LEU3_STAEQ 3-isopropylmalate dehydrogenase - Staphylococcus epidermidis (strain| ATCC 35984 / RP62A) Length = 347 Score = 138 bits (348), Expect = 5e-32 Identities = 108/349 (30%), Positives = 179/349 (51%), Gaps = 26/349 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWE-----------SIDVTPSLNADGKTVI 337 Y + + GDGIGPEI ++ + +E SID T + Sbjct: 3 YKIVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVSIDYYG-------TPL 55 Query: 338 PDESIASIKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQG--Y 496 +E++ S K L G + P + L L LR++ NLFAN+RP +G + Sbjct: 56 TNETLQSCKNADAILLGAIGGPKWTDPNNRPEHGL-LKLRKSLNLFANIRPTFVTKGASH 114 Query: 497 KTPY-----DNVDTVLIRENTEGEYSGI-EHVVVDGVVQSIKLITREASERVLRFAFQYA 658 +P + D V++RE T G Y G +V + S+K ++E ER++R AF A Sbjct: 115 LSPLKQDIVEGTDLVIVRELTSGIYFGEPSYVKKTEALDSLKYSSQEI-ERIVRIAFNLA 173 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 K K+ V K ++ S L+ + ++ K+YP +E + L+D + ++T PT ++ Sbjct: 174 NRRRK-KLTSVDKENVLSSSK-LWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQPTQFD 231 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPT 1015 V+V NL+GDILSD + + G LGL+PS + G ++E +HGSAPDIA + ANP Sbjct: 232 --VIVTENLFGDILSDEASVIPGSLGLSPSASFGQTGTRLYEPIHGSAPDIANEDKANPF 289 Query: 1016 ALLLS-SIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHE 1159 ++LS ++ + + + + AN++++ ++ + KT T DLGG+ +T E Sbjct: 290 GMVLSLALCLRESLNQNDAANELESIVYSFIQSNKT-TADLGGQYRTSE 337
>Q5HS77:LEU3_CAMJR 3-isopropylmalate dehydrogenase - Campylobacter jejuni (strain| RM1221) Length = 358 Score = 138 bits (348), Expect = 5e-32 Identities = 111/342 (32%), Positives = 183/342 (53%), Gaps = 23/342 (6%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVT-PSLNADGKTVIPDESIA 355 Y V+++ GDGIGP + + I + N ++ + S++A G + DE++ Sbjct: 4 YKVAVLAGDGIGPLVMKEALKILTFISQKYNFSFEFNEAKIGGASIDAYG-VALSDETLK 62 Query: 356 SIKRNYVALKGPLATPIGKG--------HVSLNLTLRRTFNLFANVRPCKSIQG--YKTP 505 +++ L G + P SL L LR+ FNLFAN+RPCK + + +P Sbjct: 63 LCEQSDAILFGSVGGPKWDNLPIDQRPERASL-LPLRKHFNLFANLRPCKIYESLTHASP 121 Query: 506 YDN------VDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDI 667 N VD + +RE T G Y G + + + + ++ T++ ER+ AF+ A+ I Sbjct: 122 LKNEIIQKGVDILCVRELTGGIYFGKQDLGKESAYDT-EIYTKKEIERIAHIAFESAR-I 179 Query: 668 GKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKV 847 K KV ++ KA ++ S L+ + + K+Y +I + +DNA +++V +P+ ++ V Sbjct: 180 RKKKVHLIDKANVLASSI-LWREVVANVVKDYQDINLEYMYVDNAAMQIVKNPSIFD--V 236 Query: 848 LVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTALL 1024 ++ NL+GDILSD A + G LGL S ++ D+ ++E GSAPDIA +ANP A + Sbjct: 237 MLCSNLFGDILSDELAAINGSLGLLSSASLNDKGFGLYEPAGGSAPDIAHLNIANPIAQI 296 Query: 1025 LSSIMMLQHMGLFEH-ANKIQAAIFKTLAEGKTITGDLGGKS 1147 LS+ +ML++ E A I+ AI LA+GK +T DL KS Sbjct: 297 LSAALMLKYSFKEEQAAQDIENAISLALAQGK-MTKDLNAKS 337
>P87256:LEU3A_ASPNG 3-isopropylmalate dehydrogenase A - Aspergillus niger| Length = 363 Score = 138 bits (348), Expect = 5e-32 Identities = 113/362 (31%), Positives = 174/362 (48%), Gaps = 30/362 (8%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKDIYSAANVPIKWESIDVTPSLN---ADGKTV------IP 340 Y + + GD GPE+ A+++K + I+ D+T +L G ++ + Sbjct: 4 YNIVVFAGDHWGPEVTAEAIKVLRV-----IEKSRDDITLNLQDHLLGGASIDATANPLT 58 Query: 341 DESIASIKRNYVALKGPLATPI-GKGHVSLN---LTLRRTFNLFANVRPCKSIQGYKTPY 508 DE++A+ K L G + P G G V L +R+ F N+RPC + Sbjct: 59 DEALAAAKNADAVLLGAIGGPKWGTGAVRPEQGLLNVRKEMGTFGNLRPCNFAAPSLVEH 118 Query: 509 --------DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQD 664 + VD +IRE T G Y G + + +R ER+ A Q Sbjct: 119 SPLKASVCEGVDFNIIRELTGGIYFGDRKKMTAAATMDTEPYSRAEIERITPRAHLALQH 178 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 V + KA ++ S + +AKE+P ++ + +L+D+A + +V +P N Sbjct: 179 NPPLPVWSLDKANVLATSRLWRKTVTEIMAKEFPQLKIEHQLIDSAAMIMVKNPRQLNG- 237 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNI-------GDECSIFEAVHGSAPDIAGKGL 1003 ++V NL+GDI+SD + + G LGL PS ++ G I+E +HGSAPDIAGKG+ Sbjct: 238 IIVTSNLFGDIISDEASVIPGSLGLLPSASLSGIPDGKGRVNGIYEPIHGSAPDIAGKGI 297 Query: 1004 ANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIK 1180 NP A +LS MM+Q+ G F+ A I+AA+ L G TGD+GGK+ T E AV Sbjct: 298 VNPVAAILSVAMMMQYSFGRFDEARAIEAAVRNVLESG-VRTGDIGGKATTSEVGDAVAA 356 Query: 1181 NL 1186 L Sbjct: 357 EL 358
>Q8FL76:LEU3_ECOL6 3-isopropylmalate dehydrogenase - Escherichia coli O6| Length = 363 Score = 138 bits (347), Expect = 6e-32 Identities = 110/342 (32%), Positives = 182/342 (53%), Gaps = 27/342 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKDIYSAAN---VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ Q++K + + N + I DV + + +P ++ Sbjct: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Query: 359 IKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT---- 502 ++ L G + P + H+ + L LR+ F LF+N+RP K QG + Sbjct: 65 CEQADAVLFGSVGGPKWE-HLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 Query: 503 ----PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQY 655 + D + +RE T G Y G + +G Q K E ER+ R AF+ Sbjct: 124 RADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 Query: 656 AQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPY 835 A+ + KV + KA +++ S L+ + EIA EYP++E +DNA ++++ DP+ + Sbjct: 183 ARK-RRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELTHMYIDNATMQLIKDPSQF 240 Query: 836 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANP 1012 + VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 241 D--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 Query: 1013 TALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS ++L++ + + A+ I+ AI + L EG TGDL Sbjct: 299 IAQILSLALLLRYSLDADDAASAIERAINRALEEG-IRTGDL 339
>Q8X9Z9:LEU3_ECO57 3-isopropylmalate dehydrogenase - Escherichia coli O157:H7| Length = 363 Score = 138 bits (347), Expect = 6e-32 Identities = 111/342 (32%), Positives = 182/342 (53%), Gaps = 27/342 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKDIYSAAN---VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ Q++K + + N + I DV + + +P ++ Sbjct: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Query: 359 IKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT---- 502 ++ L G + P + H+ + L LR+ F LF+N+RP K QG + Sbjct: 65 CEQADAVLFGSVGGPKWE-HLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 Query: 503 ----PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQY 655 + D + +RE T G Y G + +G Q K E ER+ R AF+ Sbjct: 124 RADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 Query: 656 AQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPY 835 A+ + KV + KA +++ S L+ + EIA EYP+IE +DNA ++++ DP+ + Sbjct: 183 ARK-RRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDIELAHMYIDNATMQLIKDPSQF 240 Query: 836 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANP 1012 + VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 241 D--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 Query: 1013 TALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS ++L++ + + A+ I+ AI + L EG TGDL Sbjct: 299 IAQILSLALLLRYSLDADDAASAIERAINRALEEG-IRTGDL 339
>Q2KYL5:LEU3_BORA1 3-isopropylmalate dehydrogenase - Bordetella avium (strain 197N)| Length = 358 Score = 138 bits (347), Expect = 6e-32 Identities = 115/357 (32%), Positives = 184/357 (51%), Gaps = 27/357 (7%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 ++++ GDGIGPEI + + A N+P++ + V + + +P ++ K ++ Sbjct: 5 IAVLPGDGIGPEIVEQAVRVLQALNLPLELQEAKVGGAAFDAFEHPLPPATLGLAKSSHA 64 Query: 377 ALKGPL------ATPIGKGHVSLNLTLRRTFNLFANVRPC------KSIQGYKTPY-DNV 517 L G + + P L LRR LFAN+RP S K + Sbjct: 65 VLFGAVGDWKYDSLPREFRPEQAILGLRRALGLFANLRPAILYPELASASSLKPEIVAGL 124 Query: 518 DTVLIRENTEGEYSGIEHVV---VDGVVQSIKL---ITREASERVLRFA---FQYAQDIG 670 D ++IRE T Y G V DGV + R A V R A F+ A+ Sbjct: 125 DIIIIRELTGDIYFGTPRGVRSAPDGVFSGEREGYDTMRYAESEVRRIAHVGFETARKRN 184 Query: 671 KPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVL 850 K K+ V KA +++ S + ++ E+A+EYP++E +DNA +++V +P ++ V+ Sbjct: 185 K-KLCSVDKANVLETSQ-FWRDIVIEVAREYPDVELSHMYVDNAAMQLVRNPRQFD--VI 240 Query: 851 VMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECS-IFEAVHGSAPDIAGKGLANPTALLL 1027 V NL+GDILSD A L G +G+ PS ++ ++E HGSAPDIAG+G+ANP A +L Sbjct: 241 VTGNLFGDILSDEAAMLTGSIGMLPSASLNASGQGLYEPSHGSAPDIAGQGIANPLATIL 300 Query: 1028 SSIMMLQH-MGLFEHANKIQAAIFKTLAEG-KTITGDLGGKSK--THEYAAAVIKNL 1186 S+ M+L++ + A++I+AA+ K LA+G +T G +K T + AV+K L Sbjct: 301 SAAMLLRYSLNQPAQADRIEAAVRKVLAQGLRTADIHEAGTTKVSTSQMGDAVLKAL 357
>Q7VC80:LEU3_PROMA 3-isopropylmalate dehydrogenase - Prochlorococcus marinus| Length = 362 Score = 137 bits (346), Expect = 8e-32 Identities = 113/350 (32%), Positives = 180/350 (51%), Gaps = 42/350 (12%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANV-----------PIKWESIDVTPSLNADGKTVI 337 + ++L+ GDGIGPEI+ K I +A + P ++I++T GK + Sbjct: 4 HKITLLTGDGIGPEISIVAKKILAALSEKHSITFTIEEKPFGGQAIELT------GKP-L 56 Query: 338 PDESIASIKRNYVALKGPLATPIG-------KGHVSLNLTLRRTFNLFANVRPCKSIQGY 496 P++++ S K + L + P + L L LR NLFAN+RP K Q Sbjct: 57 PEDTLNSCKASDAVLLAAIGDPKYDDLPRDLRPETGL-LNLRAGLNLFANIRPIKIRQAL 115 Query: 497 KTPYD-------NVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASER-------- 631 + +VD V++RE T G Y G ++ T EA ER Sbjct: 116 ISSSSLKSEIIKDVDLVVVRELTGGIYFG---------QPKGRISTEEAGERAFNTMTYS 166 Query: 632 ------VLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELL 793 + + AF ++ K K+ + KA ++++S L+ + ++YPNIE + + Sbjct: 167 DYEIDRIAKIAFDLSETRRK-KICSIDKANVLEVSQ-LWRERVIKAQEQYPNIELTHQYV 224 Query: 794 DNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVH 970 DNA +++V +P ++ V++ NL+GDI+SD A L G +G+ PS ++G++ +FE VH Sbjct: 225 DNAAMQLVREPAQFD--VILTSNLFGDIISDEAAMLTGSIGMLPSASLGEDGPGVFEPVH 282 Query: 971 GSAPDIAGKGLANPTALLLSSIMMLQHMGLFEH--ANKIQAAIFKTLAEG 1114 GSAPDIA K LANP A++LS+ MML+ GL E+ A ++ AI K L +G Sbjct: 283 GSAPDIAHKNLANPIAMILSTAMMLR-TGLMEYKAATDLENAIDKVLGKG 331
>Q1RGC4:LEU3_ECOUT 3-isopropylmalate dehydrogenase - Escherichia coli (strain UTI89 /| UPEC) Length = 364 Score = 137 bits (346), Expect = 8e-32 Identities = 110/342 (32%), Positives = 182/342 (53%), Gaps = 27/342 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKDIYSAAN---VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ Q++K + + N + I DV + + +P ++ Sbjct: 6 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 65 Query: 359 IKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT---- 502 ++ L G + P + H+ + L LR+ F LF+N+RP K QG + Sbjct: 66 CEQADAVLFGSVGGPKWE-HLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 124 Query: 503 ----PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQY 655 + D + +RE T G Y G + +G Q K E ER+ R AF+ Sbjct: 125 RADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 183 Query: 656 AQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPY 835 A+ + KV + KA +++ S L+ + EIA EYP++E +DNA ++++ DP+ + Sbjct: 184 ARK-RRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 241 Query: 836 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANP 1012 + VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 242 D--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 299 Query: 1013 TALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS ++L++ + + A+ I+ AI + L EG TGDL Sbjct: 300 IAQILSLALLLRYSLDADDAASAIERAINRALEEG-IRTGDL 340
>Q9CJN6:LEU3_PASMU 3-isopropylmalate dehydrogenase - Pasteurella multocida| Length = 359 Score = 137 bits (345), Expect = 1e-31 Identities = 106/345 (30%), Positives = 175/345 (50%), Gaps = 25/345 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKD---IYSAANVPIKWESIDVTPSLNADGKTVIPDESIAS 358 + ++++ GDGIGPEI A+++K + + + + DV + T +P+ ++ Sbjct: 4 FNIAVLSGDGIGPEIIAEAIKVLDVVQQKYAFKLNYRTFDVGGIAIDNHGTPLPEATLKG 63 Query: 359 IKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 + + L G + P + L LR+ F LF N+RP +G + Sbjct: 64 CEESDAILFGSVGGPKWEHLPPAQQPERGALLPLRKHFALFCNLRPATLYKGLEKFCPLR 123 Query: 503 ---PYDNVDTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQ 661 D V +RE T G Y G E + ++ R ER+ R AF+ A Sbjct: 124 ADISAKGFDMVTVRELTGGIYFGQPKGREGEGANEKAFDTEVYHRYEIERIARVAFETAM 183 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 K V V KA ++ +S L+ + ++AK+YP + D +DNA ++++ P ++ Sbjct: 184 KRSK-HVTSVDKANVL-ISSVLWREVVCDVAKDYPEVTLDHIYIDNATMQLIKQPEFFD- 240 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTA 1018 VL+ N++GDI+SD CA + G +G+ PS ++ ++ ++E GSAPDIAGKG+ANP A Sbjct: 241 -VLLCSNIFGDIISDECAMITGSMGMLPSASLNEKGFGLYEPAGGSAPDIAGKGIANPIA 299 Query: 1019 LLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSK 1150 +LS+ MML+H L + A I+ A+ LAEG T DL +S+ Sbjct: 300 QILSAAMMLRHSFNLNDAATAIENAVKNVLAEGHR-TADLADESQ 343
>Q24XT2:LEU3_DESHY 3-isopropylmalate dehydrogenase - Desulfitobacterium hafniense| (strain Y51) Length = 352 Score = 137 bits (345), Expect = 1e-31 Identities = 107/335 (31%), Positives = 172/335 (51%), Gaps = 22/335 (6%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSA--ANVPIKWESIDVT---PSLNADGKTVIPDESIASI 361 ++++ GDGIG EI + A A ++E D ++ GK +PDE++ Sbjct: 4 IAVLPGDGIGQEIIPQAVRVLKAVLAETDAEFEFQDYPIGGAAIELVGKA-LPDETLQGC 62 Query: 362 KRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY-------K 499 + L G + + + L LR+ N +AN+RP + I + Sbjct: 63 READAVLLGAVGGHQWDHLPASERPETAALLGLRKGLNFYANIRPVRMIPSLLATSTLKE 122 Query: 500 TPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASE--RVLRFAFQYAQDIGK 673 D VD V+IRE T G Y G E D + +T E R+L F+ A + Sbjct: 123 NVLDGVDMVVIRELTGGVYFG-EKGRSDNPRSAYDKMTYSEEEIRRILIQGFETAM-LRS 180 Query: 674 PKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLV 853 K+ V KA +++ S L+ + E+AKEYP +E +DNA +++V +P ++ V+V Sbjct: 181 KKLCSVDKANVLETSR-LWREIANELAKEYPEVELTHMYVDNAAMQLVRNPKQFD--VIV 237 Query: 854 MPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 N++GDIL+D+ + L G +G+ S ++ ++E HGSAPDIAGK LANP A +LS+ Sbjct: 238 TENMFGDILTDLASMLGGSIGMLSSASLSGTQGMYEPAHGSAPDIAGKNLANPLATILSA 297 Query: 1034 IMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 +ML++ G+ A +I++A+ K L +G TGDL Sbjct: 298 ALMLRYSFGMEAEALRIESAVEKVLEQGYR-TGDL 331
>Q8CNL2:LEU3_STAES 3-isopropylmalate dehydrogenase - Staphylococcus epidermidis (strain| ATCC 12228) Length = 347 Score = 137 bits (344), Expect = 1e-31 Identities = 107/347 (30%), Positives = 178/347 (51%), Gaps = 26/347 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWE-----------SIDVTPSLNADGKTVI 337 Y + + GDGIGPEI ++ + +E SID T + Sbjct: 3 YKIVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVSIDYYG-------TPL 55 Query: 338 PDESIASIKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQG--Y 496 +E++ S K L G + P + L L LR++ NLFAN+RP +G + Sbjct: 56 TNETLQSCKNADAILLGAIGGPKWTDPNNRPEHGL-LKLRKSLNLFANIRPTFVTKGASH 114 Query: 497 KTPY-----DNVDTVLIRENTEGEYSGI-EHVVVDGVVQSIKLITREASERVLRFAFQYA 658 +P + D V++RE T G Y G +V + S+K ++E ER++R AF A Sbjct: 115 LSPLKQDIVEGTDLVIVRELTSGIYFGEPSYVKKTEALDSLKYSSQEI-ERIVRIAFNLA 173 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 K K+ V K ++ S L+ + ++ K+YP +E + L+D + ++T PT ++ Sbjct: 174 NRRRK-KLTSVDKENVLSSSK-LWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQPTQFD 231 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPT 1015 V+V NL+GDILSD + + G LGL+PS + G ++E +HGSAPDIA + ANP Sbjct: 232 --VIVTENLFGDILSDEASVIPGSLGLSPSASFGQTGTRLYEPIHGSAPDIANEDKANPF 289 Query: 1016 ALLLS-SIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 ++LS ++ + + + + AN++++ ++ + KT T DLGG+ +T Sbjct: 290 GMVLSLALCLRESLNQNDAANELESIVYSFIQSNKT-TADLGGQYRT 335
>Q3Z5T7:LEU3_SHISS 3-isopropylmalate dehydrogenase - Shigella sonnei (strain Ss046)| Length = 363 Score = 137 bits (344), Expect = 1e-31 Identities = 110/342 (32%), Positives = 181/342 (52%), Gaps = 27/342 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKDIYSAAN---VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ Q++K + + N + I DV + + +P ++ Sbjct: 5 YHIAVLPGDGIGPEVMTQALKVLNAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Query: 359 IKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT---- 502 ++ L G + P + H+ + L LR+ F LF+N+RP K QG + Sbjct: 65 CEQADAVLFGSVGGPKWE-HLPPDQQPERGALLPLRKRFKLFSNLRPAKLYQGLEAFCPL 123 Query: 503 ----PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQY 655 + D + +RE T G Y G + +G Q K E ER+ R AF+ Sbjct: 124 RADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 Query: 656 AQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPY 835 A+ + KV + KA +++ S L+ + EIA EYP++E +DNA ++++ DP+ + Sbjct: 183 ARK-RRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 Query: 836 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANP 1012 + VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 241 D--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 Query: 1013 TALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS ++L++ + + A I+ AI + L EG TGDL Sbjct: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDL 339
>Q83SP1:LEU3_SHIFL 3-isopropylmalate dehydrogenase - Shigella flexneri| Length = 363 Score = 137 bits (344), Expect = 1e-31 Identities = 110/342 (32%), Positives = 181/342 (52%), Gaps = 27/342 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKDIYSAAN---VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ Q++K + + N + I DV + + +P ++ Sbjct: 5 YHIAVLPGDGIGPEVMTQALKVLNAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Query: 359 IKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT---- 502 ++ L G + P + H+ + L LR+ F LF+N+RP K QG + Sbjct: 65 CEQADAVLFGSVGGPKWE-HLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 Query: 503 ----PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQY 655 + D +RE T G Y G + +G Q K E ER+ R AF+ Sbjct: 124 RADIAANGFDIQCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 Query: 656 AQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPY 835 A+ + KV + KA +++ S L+ + EIA EYP++E +DNA ++++ DP+ + Sbjct: 183 ARK-RRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 Query: 836 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANP 1012 + VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 241 D--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 Query: 1013 TALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS ++L++ + + A+ I+ AI + L EG TGDL Sbjct: 299 IAQILSLALLLRYSLDADDAASAIERAINRALEEG-IRTGDL 339
>Q6LV25:LEU3_PHOPR 3-isopropylmalate dehydrogenase - Photobacterium profundum| (Photobacterium sp. (strain SS9)) Length = 362 Score = 137 bits (344), Expect = 1e-31 Identities = 101/346 (29%), Positives = 179/346 (51%), Gaps = 26/346 (7%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDESI 352 G Y ++++ GDGIGPE+ + A ++ DV + +P+ ++ Sbjct: 3 GTYKIAVLPGDGIGPEVMLQAHKVLDAVEEKFGFTLERSEHDVGGIAIDNHGCPLPESTM 62 Query: 353 ASIKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCK---SIQGYK 499 + + L G + P + H++ N L LR+ F LF N+RP + ++G+ Sbjct: 63 KGCEESDAILFGSVGGPKWE-HLAPNDQPERGALLPLRKHFQLFCNLRPAQIHSGLEGFS 121 Query: 500 TPYDNV-----DTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFAFQ 652 ++ D V++RE T G Y G E ++ R ER+ R AF+ Sbjct: 122 PLRADISERGFDIVVVRELTGGIYFGQPKGREGEGPQEKAYDTEIYHRYEIERIARIAFE 181 Query: 653 YAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTP 832 A + + V + KA +++ S L+ + E+AK+YP + + +DNA ++++ DP+ Sbjct: 182 SAM-LREKNVYSIDKANVLQSSI-LWREVVEEVAKDYPEVTLNHMYIDNATMQLIKDPSQ 239 Query: 833 YNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLAN 1009 ++ V++ N++GDI+SD CA + G +G+ PS ++ E ++E GSAPDIAGK +AN Sbjct: 240 FD--VMLCSNIFGDIISDECAMITGSMGMLPSASLNQEKFGMYEPAGGSAPDIAGKNIAN 297 Query: 1010 PTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGK 1144 P A +LS+ +ML++ + + A I+ A+ + L G+ +T DL GK Sbjct: 298 PVAQILSAALMLRYSLDEEKAARAIEQAVSQALEAGE-LTADLAGK 342
>Q5FUG5:LEU3_GLUOX 3-isopropylmalate dehydrogenase - Gluconobacter oxydans| (Gluconobacter suboxydans) Length = 369 Score = 136 bits (343), Expect = 2e-31 Identities = 117/348 (33%), Positives = 178/348 (51%), Gaps = 33/348 (9%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDI--YSAANVPIKWESIDV---TPSLNADGKTVIPDESIA 355 Y + ++ GDGIGPE+ + V I + +A+ +K E + SL G I DE I Sbjct: 5 YKLLVLAGDGIGPEVMREVARIVHWMSAHRGLKLEITEELVGAASLAVHG-VPIRDEVIE 63 Query: 356 SIKRNYVALKGPLATPIGKGHVSLN-------LTLRRTFNLFANVRPCKSIQGY------ 496 +++ L G + P HV + L LR+ LFAN+RP K Sbjct: 64 LARQSDAVLFGSVGDPAWS-HVGFDKRPEVAILKLRKELELFANLRPAKLFDALIDASAL 122 Query: 497 -KTPYDNVDTVLIRENTEGEY----SGIEHVVVDGVVQSI--KLITREASERVLRFAFQY 655 +D +++RE G Y GIE + DG + I ++ T ERV R AF Sbjct: 123 KPEVVRGLDLMIVRETVGGIYFGEPRGIE-TLPDGSRRGINTEVYTTSEIERVARVAFDL 181 Query: 656 AQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAK-EYPNIEFDAELLDNACLKVVTDPTP 832 A+ +V V K +M+ S L+ + ++ K EYP+++ L DN +++V DP Sbjct: 182 ARKRDN-RVCSVEKCNVME-SGLLWKEVVTDVHKREYPDVQLSHMLADNCAMQLVRDPNQ 239 Query: 833 YNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD------ECSIFEAVHGSAPDIAG 994 ++ V+V NL+GDILSD+ + L G LG+ PS +G +++E +HGSAPDIAG Sbjct: 240 FD--VIVTGNLFGDILSDLASMLTGSLGMLPSATLGPVRADGKRNALYEPIHGSAPDIAG 297 Query: 995 KGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 KG+ANP A +LS M+L++ + E A+ I+ A+ LA G TGD+ Sbjct: 298 KGIANPLAQILSFAMLLRYSLNRAEDADLIEMAVSNVLASGLR-TGDI 344
>P30125:LEU3_ECOLI 3-isopropylmalate dehydrogenase - Escherichia coli| Length = 363 Score = 136 bits (342), Expect = 2e-31 Identities = 110/342 (32%), Positives = 181/342 (52%), Gaps = 27/342 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKDIYSAAN---VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ Q++K + + N + I DV + + +P ++ Sbjct: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Query: 359 IKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT---- 502 ++ L G + P + H+ + L LR+ F LF+N+RP K QG + Sbjct: 65 CEQADAVLFGSVGGPKWE-HLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 Query: 503 ----PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQY 655 + D + +RE T G Y G + +G Q K E ER+ R AF+ Sbjct: 124 RADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 Query: 656 AQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPY 835 A+ + KV + KA +++ S L+ + EIA EYP++E +DNA ++++ DP+ + Sbjct: 183 ARK-RRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 Query: 836 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANP 1012 + VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 241 D--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 Query: 1013 TALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS ++L++ + + A I+ AI + L EG TGDL Sbjct: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDL 339
>P37412:LEU3_SALTY 3-isopropylmalate dehydrogenase - Salmonella typhimurium| Length = 363 Score = 135 bits (341), Expect = 3e-31 Identities = 108/341 (31%), Positives = 178/341 (52%), Gaps = 26/341 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVK---DIYSAANVPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ AQ++K + S ++ I DV + +P ++ Sbjct: 5 YHIAVLPGDGIGPEVMAQALKVMDAVRSRFDMRITTSHYDVGGIAIDNHGHPLPKATVEG 64 Query: 359 IKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 ++ L G + P + L LR+ F LF+N+RP K QG + Sbjct: 65 CEQADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 Query: 503 ---PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQYA 658 + D + +RE T G Y G + +G Q K E ER+ R AF+ A Sbjct: 125 ADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 + + KV + KA +++ S L+ + ++AK YP++E +DNA ++++ DP+ ++ Sbjct: 184 RK-RRRKVTSIDKANVLQSSI-LWREIVNDVAKTYPDVELAHMYIDNATMQLIKDPSQFD 241 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPT 1015 VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 242 --VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 Query: 1016 ALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS ++L++ + + A I+ AI + L EG TGDL Sbjct: 300 AQILSLALLLRYSLDANDAATAIEQAINRALEEG-VRTGDL 339
>Q8Z9I1:LEU3_SALTI 3-isopropylmalate dehydrogenase - Salmonella typhi| Length = 363 Score = 135 bits (341), Expect = 3e-31 Identities = 106/334 (31%), Positives = 174/334 (52%), Gaps = 26/334 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVK---DIYSAANVPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ AQ++K + S ++ I DV + +P ++ Sbjct: 5 YHIAVLPGDGIGPEVMAQALKVMDAVRSRFDMRITTSRYDVGGIAIDNHGHPLPKATVEG 64 Query: 359 IKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 ++ L G + P + L LR+ F LF+N+RP K QG + Sbjct: 65 CEQADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 Query: 503 ---PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQYA 658 + D + +RE T G Y G + +G Q K E ER+ R AF+ A Sbjct: 125 ADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 + + KV + KA +++ S L+ + ++AK YP++E +DNA ++++ DP+ ++ Sbjct: 184 RK-RRRKVTSIDKANVLQSSI-LWREIVNDVAKAYPDVELAHMYIDNATMQLIKDPSQFD 241 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAPDIAGKGLANPT 1015 VL+ NL+GDILSD CA + G +G+ PS ++ + E ++E GSAPDIAGK +ANP Sbjct: 242 --VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQEFGLYEPAGGSAPDIAGKNIANPI 299 Query: 1016 ALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 A +LS ++L++ + E A I+ AI + L EG Sbjct: 300 AQILSLALLLRYSLDADEAATAIEQAINRALEEG 333
>Q5PDG2:LEU3_SALPA 3-isopropylmalate dehydrogenase - Salmonella paratyphi-a| Length = 363 Score = 135 bits (341), Expect = 3e-31 Identities = 108/341 (31%), Positives = 178/341 (52%), Gaps = 26/341 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVK---DIYSAANVPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ AQ++K + S ++ I DV + +P ++ Sbjct: 5 YHIAVLPGDGIGPEVMAQALKVMDAVRSRFDMRITTSRYDVGGIAIDNHGHPLPKATVEG 64 Query: 359 IKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 ++ L G + P + L LR+ F LF+N+RP K QG + Sbjct: 65 CEQADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 Query: 503 ---PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQYA 658 + D + +RE T G Y G + +G Q K E ER+ R AF+ A Sbjct: 125 ADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 + + KV + KA +++ S L+ + ++AK YP++E +DNA ++++ DP+ ++ Sbjct: 184 RK-RRRKVTSIDKANVLQSSI-LWREIVNDVAKTYPDVELAHMYIDNATMQLIKDPSQFD 241 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPT 1015 VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 242 --VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 Query: 1016 ALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS ++L++ + + A I+ AI + L EG TGDL Sbjct: 300 AQILSLALLLRYSLDANDAATAIEQAINRALEEG-VRTGDL 339
>Q57TE7:LEU3_SALCH 3-isopropylmalate dehydrogenase - Salmonella choleraesuis| Length = 363 Score = 135 bits (341), Expect = 3e-31 Identities = 108/341 (31%), Positives = 178/341 (52%), Gaps = 26/341 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVK---DIYSAANVPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ AQ++K + S ++ I DV + +P ++ Sbjct: 5 YHIAVLPGDGIGPEVMAQALKVMDAVRSRFDMRITTSHYDVGGIAIDNHGHPLPKATVEG 64 Query: 359 IKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 ++ L G + P + L LR+ F LF+N+RP K QG + Sbjct: 65 CEQADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 Query: 503 ---PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQYA 658 + D + +RE T G Y G + +G Q K E ER+ R AF+ A Sbjct: 125 ADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 + + KV + KA +++ S L+ + ++AK YP++E +DNA ++++ DP+ ++ Sbjct: 184 RK-RRRKVTSIDKANVLQSSI-LWREIVNDVAKTYPDVELAHMYIDNATMQLIKDPSQFD 241 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPT 1015 VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 242 --VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 Query: 1016 ALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS ++L++ + + A I+ AI + L EG TGDL Sbjct: 300 AQILSLALLLRYSLDANDAATAIEQAINRALEEG-VRTGDL 339
>Q6GF15:LEU3_STAAR 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain| MRSA252) Length = 348 Score = 135 bits (340), Expect = 4e-31 Identities = 107/341 (31%), Positives = 176/341 (51%), Gaps = 20/341 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQ---SVKDIYSAA---NVPIKWESIDVTPSLNADGKTVIPDESI 352 Y + + GDGIGPEI S+ +I S N I+ S++ G+ + ++++ Sbjct: 3 YNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGA-SIDTFGEP-LTEKTL 60 Query: 353 ASIKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 + KR L G + P + L L LR++ NLFAN+RP ++G + Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGL-LKLRKSLNLFANIRPTTVVKGASSLSPLK 119 Query: 503 --PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 + D V++RE T G Y G + TRE ER++ AF+ A + Sbjct: 120 AERVEGTDLVIVRELTSGIYFGEPRYFNNHEALDSLTYTREEIERIVHVAFKLAAS-RRG 178 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 K+ V K ++ S L+ + E+++ YP + + L+D + ++T+P ++ V+V Sbjct: 179 KLTSVDKENVLASSK-LWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFD--VIVY 235 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 NL+GDILSD + + G LGL+PS + D ++E +HGSAPDIAGK +ANP ++LS Sbjct: 236 ENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSL 295 Query: 1034 IMML-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 M L + + + A++++ I+ + G+T T DLGGK T Sbjct: 296 AMCLRESLNQPDAADELEQHIYNMIEHGQT-TADLGGKLNT 335
>Q3AEQ2:LEU3_CARHZ 3-isopropylmalate dehydrogenase - Carboxydothermus hydrogenoformans| (strain Z-2901 / DSM 6008) Length = 374 Score = 135 bits (340), Expect = 4e-31 Identities = 101/345 (29%), Positives = 177/345 (51%), Gaps = 28/345 (8%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDESI 352 G + + ++ GDGIGPEI + + A + ++ + + + +P+E++ Sbjct: 8 GPFKILVLPGDGIGPEIIKEAVKVLKALGEKKGITFNFQYGLIGGAAIDERGVPLPEETV 67 Query: 353 ASIKRNYVALKGPLATPIG-------KGHVSLNLTLRRTFNLFANVRPCKSIQGYKTP-- 505 K+ L G + P + + L +R+ F+L+AN+RP K Sbjct: 68 ELGKQCDAILLGAVGGPKWDNLPPEIRPELGGLLKIRKVFDLYANLRPVMFFPELKNASP 127 Query: 506 -----YDNVDTVLIRENTEGEYSGI---------EHVVVDGVVQSIKLITREASERVLRF 643 + VD +++RE T G Y G E V+D ++ + K + ERV+R Sbjct: 128 LKPDIIEGVDILMVRELTGGLYFGEKKRFTTEQGEQAVIDTLIYTEKEV-----ERVVRL 182 Query: 644 AFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTD 823 F+ AQ + K+ +V KA +++ S + + EI KEYP++E +DN ++++ + Sbjct: 183 GFELAQK-RRGKLTLVDKANVLE-SSRFWREITGEIKKEYPDVELSYMYVDNCAMQLIRN 240 Query: 824 PTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGL 1003 P ++ V+V N++GDIL+D + L G +GL PS ++ + ++E +HGSAPDIAG+ Sbjct: 241 PRQFD--VIVTENMFGDILTDEGSVLAGSIGLLPSASLNGKFGLYEPIHGSAPDIAGQNK 298 Query: 1004 ANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 ANP A +LS+ MML++ + E A I+ A+ L +G TGD+ Sbjct: 299 ANPLATILSAGMMLRYSLDCPEEALLIEKAVKAVLQKGYR-TGDI 342
>Q7W929:LEU3_BORPA 3-isopropylmalate dehydrogenase - Bordetella parapertussis| Length = 358 Score = 135 bits (340), Expect = 4e-31 Identities = 109/359 (30%), Positives = 185/359 (51%), Gaps = 27/359 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRN 370 + ++++ GDGIGPEI + + + A ++P++ V + + +P ++ + + Sbjct: 3 HQIAVLPGDGIGPEIVEQAERVLKALDLPLELRQAPVGGAAFDQFEHPLPPATLELAQGS 62 Query: 371 YVALKGPLAT------PIGKGHVSLNLTLRRTFNLFANVRPC------KSIQGYKTPY-D 511 + L G + P L LR+ LFAN+RP S K Sbjct: 63 HAVLFGAVGDWKYDTLPREFRPEQAILGLRKALGLFANLRPAILYPELASASSLKPEIVS 122 Query: 512 NVDTVLIRENTEGEYSGIEHVV---VDGVV----QSIKLITREASE--RVLRFAFQYAQD 664 +D ++IRE T Y G V DG + + SE R+ R F+ A+ Sbjct: 123 GLDILIIRELTGDIYFGTPRGVRTAADGAFAGEREGYDTMRYAESEVRRIARIGFESARK 182 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 K K+ V KA +++ S + +L E++++YP++E +DNA +++V +P ++ Sbjct: 183 RNK-KLCSVDKANVLETSQ-FWRDLVIEVSRDYPDVELSHMYVDNAAMQLVRNPRQFD-- 238 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECS-IFEAVHGSAPDIAGKGLANPTAL 1021 V+V NL+GDILSD A L G +G+ PS ++ ++E HGSAPDIAG+G+ANP A Sbjct: 239 VIVTGNLFGDILSDEAAMLTGSIGMLPSASLNAAGQGLYEPSHGSAPDIAGQGIANPLAT 298 Query: 1022 LLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG-KTITGDLGGKSK--THEYAAAVIKNL 1186 +LS+ M+L++ + L A++++AA+ K LA+G +T G +K T + AV+K L Sbjct: 299 ILSAAMLLRYSLNLAPQADRVEAAVRKVLADGLRTADIHEAGTTKVSTSQMGDAVLKAL 357
>Q7VQJ7:LEU3_BLOFL 3-isopropylmalate dehydrogenase - Blochmannia floridanus| Length = 364 Score = 135 bits (340), Expect = 4e-31 Identities = 104/345 (30%), Positives = 172/345 (49%), Gaps = 33/345 (9%) Frame = +2 Query: 179 SDGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTV------IP 340 ++ Y ++++ GDGIGPEI Q I + V K++ +T G + +P Sbjct: 2 NNNTYHIAILPGDGIGPEIMQQAYKILNT--VKNKFKINIITTEYKVGGNALDLEGSPLP 59 Query: 341 DESIASIKRNYVALKGPLATP-------IGKGHVSLNLTLRRTFNLFANVRPCK------ 481 ++I + +++ L G + P + LTLR+ FNLF N+RP Sbjct: 60 KDTIKNCEKSNAILFGAVGGPKWNNINETSRPEFGALLTLRKHFNLFINLRPIYLPIELI 119 Query: 482 SIQGYKTPY--DNVDTVLIRENTEGEY-------SGI---EHVVVDGVVQSIKLITREAS 625 ++ K +D + IRE G Y SGI EH + ++ Sbjct: 120 NLSPLKPEIISQGLDMICIRELIGGIYFGKPQGKSGIRSQEHAFDTAIYHRFEI------ 173 Query: 626 ERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNAC 805 ER+ FAF+ AQ K V + KA ++ S L+ + E+A YPN+ +DNA Sbjct: 174 ERIAHFAFKLAQKRRK-HVTSIDKANVLHTSM-LWRKVVSEVASNYPNVHLQHLYVDNAS 231 Query: 806 LKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAP 982 ++++ +P+ ++ V++ PNL+GDILSD CA + G +G+ PS ++ + ++E GSAP Sbjct: 232 MQLIRNPSAFD--VILCPNLFGDILSDECAEINGSIGILPSASLNEHNFGLYEPAGGSAP 289 Query: 983 DIAGKGLANPTALLLSSIMMLQHMGLFEH-ANKIQAAIFKTLAEG 1114 DIAGK +ANP A +LS+ ++ ++ H A I+ A++K L G Sbjct: 290 DIAGKNIANPIAQILSTALLFRYSLKLNHVAITIEKAVYKALTLG 334
>Q7WKH4:LEU32_BORBR 3-isopropylmalate dehydrogenase 2 - Bordetella bronchiseptica| (Alcaligenes bronchisepticus) Length = 358 Score = 135 bits (340), Expect = 4e-31 Identities = 109/359 (30%), Positives = 185/359 (51%), Gaps = 27/359 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRN 370 + ++++ GDGIGPEI + + + A ++P++ V + + +P ++ + + Sbjct: 3 HQIAVLPGDGIGPEIVEQAERVLKALDLPLELRQAPVGGAAFDQFEHPLPPATLELAQGS 62 Query: 371 YVALKGPLAT------PIGKGHVSLNLTLRRTFNLFANVRPC------KSIQGYKTPY-D 511 + L G + P L LR+ LFAN+RP S K Sbjct: 63 HAVLFGAVGDWKYDTLPREFRPEQAILGLRKALGLFANLRPAILYPELASASSLKPEIVS 122 Query: 512 NVDTVLIRENTEGEYSGIEHVV---VDGVV----QSIKLITREASE--RVLRFAFQYAQD 664 +D ++IRE T Y G V DG + + SE R+ R F+ A+ Sbjct: 123 GLDILIIRELTGDIYFGTPRGVRTAADGAFAGEREGYDTMRYAESEVRRIARIGFESARK 182 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 K K+ V KA +++ S + +L E++++YP++E +DNA +++V +P ++ Sbjct: 183 RNK-KLCSVDKANVLETSQ-FWRDLVIEVSRDYPDVELSHMYVDNAAMQLVRNPRQFD-- 238 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECS-IFEAVHGSAPDIAGKGLANPTAL 1021 V+V NL+GDILSD A L G +G+ PS ++ ++E HGSAPDIAG+G+ANP A Sbjct: 239 VIVTGNLFGDILSDEAAMLTGSIGMLPSASLNAAGQGLYEPSHGSAPDIAGQGIANPLAT 298 Query: 1022 LLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG-KTITGDLGGKSK--THEYAAAVIKNL 1186 +LS+ M+L++ + L A++++AA+ K LA+G +T G +K T + AV+K L Sbjct: 299 ILSAAMLLRYSLNLAPQADRVEAAVRKVLADGLRTADIHEAGTTKVSTSQMGDAVLKAL 357
>Q32K21:LEU3_SHIDS 3-isopropylmalate dehydrogenase - Shigella dysenteriae serotype 1| (strain Sd197) Length = 363 Score = 135 bits (339), Expect = 5e-31 Identities = 106/335 (31%), Positives = 177/335 (52%), Gaps = 27/335 (8%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKDIYSAAN---VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++ + GDGIGPE+ Q++K + + N + I DV + + +P ++ Sbjct: 5 YHIAALPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Query: 359 IKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT---- 502 ++ L G + P + H+ + L LR+ F LF+N+RP K QG + Sbjct: 65 CEQADAVLFGSVGGPKWE-HLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 Query: 503 ----PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQY 655 + D + +RE T G Y G + +G Q K E ER+ R AF+ Sbjct: 124 RADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 Query: 656 AQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPY 835 A+ + KV + KA +++ S L+ + EIA EYP++E +DNA ++++ DP+ + Sbjct: 183 ARK-RRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 Query: 836 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANP 1012 + VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 241 D--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 Query: 1013 TALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 A +LS ++L++ + + A+ I+ AI + L EG Sbjct: 299 IAQILSLALLLRYSLDADDAASAIERAINRALEEG 333
>Q46LE2:LEU3_PROMT 3-isopropylmalate dehydrogenase - Prochlorococcus marinus (strain| NATL2A) Length = 359 Score = 135 bits (339), Expect = 5e-31 Identities = 111/336 (33%), Positives = 174/336 (51%), Gaps = 28/336 (8%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPS-LNADGKTVIPDESIA 355 Y ++L+ GDGIGPEI I + IK++ + S +++DG PD ++ Sbjct: 4 YKITLLPGDGIGPEITNVTHKILDLVSRKFGFEIKFKEMPFGGSAIDSDG-IPFPDRTLQ 62 Query: 356 SIKRNYVALKGPLATPI------GKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYD-- 511 K + L + P K + L LR + +LFAN+RP K I Sbjct: 63 ECKNSDAVLLAAIGDPKYDELPREKRPETGLLNLRSSLDLFANIRPVKIIPSLTKASSLK 122 Query: 512 -----NVDTVLIRENTEGEYSGIE--HVVVDGVVQSIKLITREASE--RVLRFAFQYAQD 664 VD V++RE T G Y G + D ++ +T + E R+ AF+ A+ Sbjct: 123 EDFVKEVDLVVVRELTSGIYFGEPKGRIKTDKGERAFNTMTYTSEEVNRIAEIAFKLAKQ 182 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGRE----IAKEYPNIEFDAELLDNACLKVVTDPTP 832 + KV V KA ++ +S L RE ++ +Y +IE + +DNA +++V +P+ Sbjct: 183 RNQ-KVCSVDKANVLDVSQ-----LWREETILVSNKYKDIELTHQYVDNAAMQLVRNPSQ 236 Query: 833 YNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLAN 1009 ++ V++ NL+GDILSD+ A L G +G+ PS ++ D +FE VHGSAPDIAGK +AN Sbjct: 237 FD--VILTGNLFGDILSDIAAMLTGSIGMLPSASLTTDGPGVFEPVHGSAPDIAGKDIAN 294 Query: 1010 PTALLLSSIMMLQ-HMGLFEHANKIQAAIFKTLAEG 1114 P A+LLS+ MML+ + E A ++ AI + L +G Sbjct: 295 PIAMLLSAAMMLKIALNETEAATFLENAINEILNDG 330
>Q31B91:LEU3_PROM9 3-isopropylmalate dehydrogenase - Prochlorococcus marinus (strain MIT| 9312) Length = 357 Score = 135 bits (339), Expect = 5e-31 Identities = 109/339 (32%), Positives = 173/339 (51%), Gaps = 31/339 (9%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGK-----TVIPDESIA 355 Y + L+ GDGIGPEI++ K + + + +I++ L T PDE++ Sbjct: 4 YKIVLLSGDGIGPEISEVSKKVLKKLSRKHNF-NIEIIEKLFGGIAYEKYGTPAPDETLD 62 Query: 356 SIKR------------NYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY- 496 K+ Y +L L G L LR LFAN+RP K + Sbjct: 63 QCKKCDAVLLACVGDIKYDSLARELRPESGL------LKLRSALGLFANIRPVKIRKSLV 116 Query: 497 ------KTPYDNVDTVLIRENTEGEYSGIE--HVVVDGVVQSIKLITREASE--RVLRFA 646 K +NVD +++RE G Y G H+ + ++ + +++E R+ A Sbjct: 117 NTSTLKKEIVENVDLIVVRELIGGIYFGKPRGHITNTKIPKAFNTMVYDSAEIERITEIA 176 Query: 647 FQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDP 826 + A K K+ V K+ ++++S L+ + I + NI +DNA +++V DP Sbjct: 177 IKIANQRNK-KICSVDKSNVLEVSQ-LWRDTVLNITLKDKNISLSNMYVDNAAMQLVRDP 234 Query: 827 TPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGL 1003 + ++ V++ NL+GDILSD+ A L G +G+ PS ++ + +FE VHGSAPDIAGK + Sbjct: 235 SQFD--VILTSNLFGDILSDLAAMLTGSIGMLPSASLNNNGPGVFEPVHGSAPDIAGKNI 292 Query: 1004 ANPTALLLSSIMMLQHMGLFEH--ANKIQAAIFKTLAEG 1114 ANP A+LLS+ MML+ +GL E A ++ A+ K LAEG Sbjct: 293 ANPIAMLLSASMMLK-IGLNEEEAAKNLETAVDKVLAEG 330
>Q66EM2:LEU3_YERPS 3-isopropylmalate dehydrogenase - Yersinia pseudotuberculosis| Length = 363 Score = 134 bits (338), Expect = 7e-31 Identities = 107/358 (29%), Positives = 177/358 (49%), Gaps = 28/358 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ + A + I DV + + +P ++A Sbjct: 5 YHIAVLPGDGIGPEVMAQASKVLDAVRQRFGLKISTSVYDVGGAAIDRHGSPLPAATVAG 64 Query: 359 IKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 ++ L G + P + L LR+ F LF+N+RP + QG + Sbjct: 65 CEQADAILFGSVGGPKWEHLPPAEQPERGALLPLRKHFKLFSNLRPARLYQGLEDFCPLR 124 Query: 503 ---PYDNVDTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQ 661 D + +RE T G Y G E + ++ R ER+ R AF+ A+ Sbjct: 125 SDIAARGFDILCVRELTGGIYFGQPKGREGQGMHERAFDTEVYHRFEIERIARIAFESAR 184 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 + KV + KA +++ S L+ + IA +YP++ +DNA ++++ DP+ ++ Sbjct: 185 K-RRSKVTSIDKANVLQSSI-LWREVVNGIAADYPDVALSHMYIDNATMQLIKDPSQFD- 241 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTA 1018 VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP A Sbjct: 242 -VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 Query: 1019 LLLSSIMMLQ-HMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSK---THEYAAAVIK 1180 +LS I++L+ +G + A+ I+ AI + L +G T DL G THE + K Sbjct: 301 QILSLILLLRFSLGKDDAADAIERAINQALEQGYR-TADLAGDGHAIGTHEMGDIIAK 357
>Q6G7Q0:LEU3_STAAS 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain| MSSA476) Length = 348 Score = 134 bits (338), Expect = 7e-31 Identities = 107/341 (31%), Positives = 176/341 (51%), Gaps = 20/341 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQ---SVKDIYSAA---NVPIKWESIDVTPSLNADGKTVIPDESI 352 Y + + GDGIGPEI S+ +I S N I+ S++ G+ + ++++ Sbjct: 3 YNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGA-SIDTFGEP-LTEKTL 60 Query: 353 ASIKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 + KR L G + P + L L LR++ NLFAN+RP ++G + Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGL-LKLRKSLNLFANIRPTTVVKGASSLSPLK 119 Query: 503 --PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 + D V++RE T G Y G + TRE ER++ AF+ A + Sbjct: 120 EERVEGTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLAAS-RRG 178 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 K+ V K ++ S L+ + E+++ YP + + L+D + ++T+P ++ V+V Sbjct: 179 KLTSVDKENVLASSK-LWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFD--VIVC 235 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 NL+GDILSD + + G LGL+PS + D ++E +HGSAPDIAGK +ANP ++LS Sbjct: 236 ENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSL 295 Query: 1034 IMML-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 M L + + + A++++ I+ + G+T T DLGGK T Sbjct: 296 AMCLRESLNQPDAADELEQHIYNMIEHGQT-TADLGGKLNT 335
>P65101:LEU3_STAAN 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain N315)| Length = 348 Score = 134 bits (338), Expect = 7e-31 Identities = 107/341 (31%), Positives = 176/341 (51%), Gaps = 20/341 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQ---SVKDIYSAA---NVPIKWESIDVTPSLNADGKTVIPDESI 352 Y + + GDGIGPEI S+ +I S N I+ S++ G+ + ++++ Sbjct: 3 YNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGA-SIDTFGEP-LTEKTL 60 Query: 353 ASIKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 + KR L G + P + L L LR++ NLFAN+RP ++G + Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGL-LKLRKSLNLFANIRPTTVVKGASSLSPLK 119 Query: 503 --PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 + D V++RE T G Y G + TRE ER++ AF+ A + Sbjct: 120 EERVEGTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLAAS-RRG 178 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 K+ V K ++ S L+ + E+++ YP + + L+D + ++T+P ++ V+V Sbjct: 179 KLTSVDKENVLASSK-LWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFD--VIVC 235 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 NL+GDILSD + + G LGL+PS + D ++E +HGSAPDIAGK +ANP ++LS Sbjct: 236 ENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSL 295 Query: 1034 IMML-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 M L + + + A++++ I+ + G+T T DLGGK T Sbjct: 296 AMCLRESLNQPDAADELEQHIYNMIEHGQT-TADLGGKLNT 335
>P65100:LEU3_STAAM 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain Mu50| / ATCC 700699) Length = 348 Score = 134 bits (338), Expect = 7e-31 Identities = 107/341 (31%), Positives = 176/341 (51%), Gaps = 20/341 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQ---SVKDIYSAA---NVPIKWESIDVTPSLNADGKTVIPDESI 352 Y + + GDGIGPEI S+ +I S N I+ S++ G+ + ++++ Sbjct: 3 YNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGA-SIDTFGEP-LTEKTL 60 Query: 353 ASIKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 + KR L G + P + L L LR++ NLFAN+RP ++G + Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGL-LKLRKSLNLFANIRPTTVVKGASSLSPLK 119 Query: 503 --PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 + D V++RE T G Y G + TRE ER++ AF+ A + Sbjct: 120 EERVEGTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLAAS-RRG 178 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 K+ V K ++ S L+ + E+++ YP + + L+D + ++T+P ++ V+V Sbjct: 179 KLTSVDKENVLASSK-LWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFD--VIVC 235 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 NL+GDILSD + + G LGL+PS + D ++E +HGSAPDIAGK +ANP ++LS Sbjct: 236 ENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSL 295 Query: 1034 IMML-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 M L + + + A++++ I+ + G+T T DLGGK T Sbjct: 296 AMCLRESLNQPDAADELEQHIYNMIEHGQT-TADLGGKLNT 335
>Q326G2:LEU3_SHIBS 3-isopropylmalate dehydrogenase - Shigella boydii serotype 4 (strain| Sb227) Length = 363 Score = 134 bits (338), Expect = 7e-31 Identities = 109/342 (31%), Positives = 180/342 (52%), Gaps = 27/342 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKDIYSAAN---VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ Q++K + + N + I DV + + +P ++ Sbjct: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Query: 359 IKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCKSIQGYKT---- 502 ++ L G + P + H+ + L LR+ F LF+N+RP K QG + Sbjct: 65 CEQADAVLFGSVGGPKWE-HLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 Query: 503 ----PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQY 655 + D + +RE T G Y G + +G Q K E ER+ R AF+ Sbjct: 124 RADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 Query: 656 AQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPY 835 A+ + KV + KA +++ S L+ + EIA EYP++E +DNA ++++ DP+ + Sbjct: 183 ARK-RRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 Query: 836 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANP 1012 + VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDI GK +ANP Sbjct: 241 D--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDITGKNIANP 298 Query: 1013 TALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS ++L++ + + A I+ AI + L EG TGDL Sbjct: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDL 339
>P48572:LEU3_BUCRP 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Rhopalosiphum padi Length = 363 Score = 134 bits (338), Expect = 7e-31 Identities = 106/372 (28%), Positives = 185/372 (49%), Gaps = 39/372 (10%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTP-SLNADGKTVIPDESI 352 K+ ++++ GDGIGPEI + I + ++P++ V +++ +G +P+E++ Sbjct: 4 KFRIAVLPGDGIGPEIMREAYKILNILEKNFSLPLEIREFSVGGIAIDREG-IALPEETL 62 Query: 353 ASIKRNYVALKGPLA------TPI-GKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT--- 502 + + L G + PI + + L LR+ FNLF+N+RP K K Sbjct: 63 RGCENSDAILFGSVGGKKWDYLPIESRPERASLLPLRKHFNLFSNLRPAKLYSDLKNLSP 122 Query: 503 -----PYDNVDTVLIRE---------------NTEGEYSGIEHVVVDGVVQSIKLITREA 622 + D + +RE N GEYS + D ++ Sbjct: 123 LRSNIVRNGFDILCVRELTGGIYFGKPKGRSKNENGEYSFDTEIYYDFEIK--------- 173 Query: 623 SERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNA 802 R+ AF+ A + KV + K+ ++ S L+ + E++K YPNI +DNA Sbjct: 174 --RIAHLAFELASS-RRCKVCSIDKSNVLASSI-LWREIVEEVSKNYPNIILSHLYIDNA 229 Query: 803 CLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSA 979 C++++ +P+ ++ VL+ N++GDI+SD CA + G +G+ PS ++ + ++E GSA Sbjct: 230 CMQIIKNPSQFD--VLLCSNIFGDIISDECAMITGSIGMLPSASLNSKKFGLYEPAGGSA 287 Query: 980 PDIAGKGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKS--K 1150 PDI GK +ANP A +LS M+++H M L E A+KI +++++ L G GK+ K Sbjct: 288 PDIEGKNIANPIAQILSLSMLIRHSMNLNEIADKIDSSVYRALKAGYRTLDISDGKNYIK 347 Query: 1151 THEYAAAVIKNL 1186 T+E + K L Sbjct: 348 TNEMGDIIAKFL 359
>Q493R1:LEU3_BLOPB 3-isopropylmalate dehydrogenase - Blochmannia pennsylvanicus (strain| BPEN) Length = 366 Score = 134 bits (337), Expect = 9e-31 Identities = 113/375 (30%), Positives = 189/375 (50%), Gaps = 41/375 (10%) Frame = +2 Query: 182 DGKYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPS--------LNADGKTVI 337 + Y ++++ GDGIGPE + + +Y NV K I++ + +N++G T Sbjct: 2 NNNYHIAVLPGDGIGPE---TTRQVYKILNVIKKQFQINIVTTEHKIGGDAINSEG-TPF 57 Query: 338 PDESIASIKRNYVALKGPLATPIG---KGHVSLN----LTLRRTFNLFANVRPCKSIQGY 496 P ++ +++ L G + P KG S L LR+ FNLFAN+RP Sbjct: 58 PKSTLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADEL 117 Query: 497 K--TPYD------NVDTVLIRENTEGEY---------SGIEHVVVDGVVQSIKLITREAS 625 K +P + +D + +RE T G Y +G+ D V R Sbjct: 118 KELSPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGLNEYAFDTAVYH-----RFEI 172 Query: 626 ERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNAC 805 ER+ AF+ AQ K +V + KA ++ S L+ + +AK YP++E + +DNA Sbjct: 173 ERIANIAFKLAQKRRK-RVSSIDKANVLHTSM-LWREVVSHLAKNYPDVELEHLYIDNAS 230 Query: 806 LKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAP 982 ++++ +P+ ++ +++ PNL+GDILSD CA + G +G+ PS +I + ++E GSAP Sbjct: 231 MQLINNPSKFD--IILCPNLFGDILSDECAMISGSIGMLPSASINEHNFGLYEPAGGSAP 288 Query: 983 DIAGKGLANPTALLLSSIMMLQHMGLFEH-ANKIQAAIFKTLAEGKTITGDLGGK----- 1144 DIA K +ANP A +LS ++ ++ +H A KI+ A+ + L G T D+ K Sbjct: 289 DIAEKNIANPIAHILSIALLFRYSLKLDHIAIKIEKAVSQALMLGYR-TIDIAKKHEKSI 347 Query: 1145 --SKTHEYAAAVIKN 1183 ++ + AA+IKN Sbjct: 348 STNEMGDIIAALIKN 362
>Q9FMT1:LEU33_ARATH 3-isopropylmalate dehydrogenase 3, chloroplast precursor -| Arabidopsis thaliana (Mouse-ear cress) Length = 409 Score = 134 bits (337), Expect = 9e-31 Identities = 110/385 (28%), Positives = 191/385 (49%), Gaps = 39/385 (10%) Frame = +2 Query: 98 HISRPAFQIVQSRFASSQVAAFQGQ------KGSDGK--YTVSLIEGDGIGPEIAQSVKD 253 +IS A +IV +++S F+ S GK Y ++L+ GDGIGPE+ K+ Sbjct: 8 NISLNAIKIVPGKYSSLTDHQFRAPYRIRCAAASPGKKRYNIALLPGDGIGPEVISVAKN 67 Query: 254 IYSAAN-----------VPIKWESIDVTPSLNADGKTVIPDESIASIKRNYVALKGPLAT 400 + A +P+ ++D+ +P+E+ + K + L G + Sbjct: 68 VLQKAGSLEGLEFDFKEMPVGGAALDLVG-------VPLPEETFTAAKLSDAILLGAIGG 120 Query: 401 ---PIGKGHVSLNLTL---RRTFNLFANVRPCKSIQGY-------KTPYDNVDTVLIREN 541 + H+ + L RR +FAN+RP + K + VD +++RE Sbjct: 121 YKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVAEGVDMMIVREL 180 Query: 542 TEGEYSGIEHVVV-----DGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRVVHKATI 706 T G Y G + + V S ++ +R+ R AF+ A+ + K+ V KA + Sbjct: 181 TGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFETARK-RRGKLCSVDKANV 239 Query: 707 MKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSD 886 + S L+ +A EYP++E +DNA ++++ DP ++ +V N++GDILSD Sbjct: 240 LDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFD--TIVTNNIFGDILSD 296 Query: 887 MCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQH-MGL 1060 + + G +G+ PS ++G+ +FE +HGSAPDIAG+ ANP A +LS+ M+L++ +G Sbjct: 297 EASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGE 356 Query: 1061 FEHANKIQAAIFKTLAEGKTITGDL 1135 + A +I+ A+ L +G TGD+ Sbjct: 357 EKAAKRIEDAVVDALNKGFR-TGDI 380
>Q9LQK9:IDH4_ARATH Putative isocitrate dehydrogenase [NAD] subunit-like 4 - Arabidopsis| thaliana (Mouse-ear cress) Length = 294 Score = 134 bits (337), Expect = 9e-31 Identities = 102/324 (31%), Positives = 169/324 (52%), Gaps = 2/324 (0%) Frame = +2 Query: 221 IGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYVALKGPLAT 400 I + +V + A P+ +E T + + E + SI++N V L G + Sbjct: 8 IDSNVTNAVHQVMDAMQAPVYFE----TYIIKGKNMNHLTWEVVDSIRKNKVCLNGRVNN 63 Query: 401 PIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYDNVDTVLIRENTEGEYSGIEHVVV 580 + G R+ +LFA++ C ++ G + ++NVD V+IRENTEGEY+G EH VV Sbjct: 64 SLCGG-------ARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVV 116 Query: 581 DGVVQSIKL-ITREASERVLRFAFQYAQDIGKPKVRVVH-KATIMKMSDGLFLNLGREIA 754 GV++S ++ +T+ S+R+ ++AF+YA + KV VH K++D FL +E+A Sbjct: 117 PGVIESFQVTMTKFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVA 176 Query: 755 KEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGN 934 K YPNI ++ + A + N K L I++++ +G+ G G+ Sbjct: 177 KMYPNITYN----EIASRETRAIRRHSNSKSL------WAIIANIASGVAG-------GS 219 Query: 935 IGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLFEHANKIQAAIFKTLAEG 1114 GD+ +IFE V GS + NP ALL SS+MML+H+ L A++++ A+ + ++EG Sbjct: 220 FGDDYAIFEQV-GSVGN-----HKNPVALLFSSVMMLRHLLLPLFADRLKTAVTRVISEG 273 Query: 1115 KTITGDLGGKSKTHEYAAAVIKNL 1186 K + + T E +VI NL Sbjct: 274 KCGNSN----TTTQEVVDSVIANL 293
>Q7U840:LEU3_SYNPX 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain WH8102)| Length = 357 Score = 134 bits (336), Expect = 1e-30 Identities = 113/341 (33%), Positives = 178/341 (52%), Gaps = 25/341 (7%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWE-----SIDVTPSLNADGKTVIPDESI 352 ++ V L+ GDGIGPEI + + A + +E + +++A G+ +P ++ Sbjct: 3 QHRVVLLPGDGIGPEITAVARQLLEAVSQRHGFELCFDGQLIGGSAIDACGEP-LPASTL 61 Query: 353 ASIKRNYVALKGPLATPI------GKGHVSLNLTLRRTFNLFANVRPCKSIQGY------ 496 + K L + +P K + L LR LFAN+RP K + Sbjct: 62 DACKAADAVLLAAIGSPRFDNLPRDKRPETGLLGLRSGMALFANLRPVKIVPALIGASSL 121 Query: 497 -KTPYDNVDTVLIRENTEGEYSGIE--HVVVDGVVQSIKLITREASE--RVLRFAFQYAQ 661 + VD +++RE T G Y G + DG + +T +SE R+ R AF A+ Sbjct: 122 RPEVIEGVDLMVVRELTGGIYFGQPKGRIQADGEERGFNTMTYSSSEVDRIARVAFDLAR 181 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 + + + V KA ++ +S L+ + +A Y ++E +DNA +++V P ++ Sbjct: 182 E-RRGNLCSVDKANVLDVSQ-LWRDRVDAMAPAYSDVEVSHMYVDNAAMQLVRSPRQFD- 238 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTA 1018 VL+ NL+GDILSD A L G +G+ PS ++G +C +FE VHGSAPDIAG+ ANP A Sbjct: 239 -VLLTGNLFGDILSDEAAMLTGSIGMLPSASLGSDCPGLFEPVHGSAPDIAGQDKANPMA 297 Query: 1019 LLLSSIMMLQHMGL--FEHANKIQAAIFKTLAEGKTITGDL 1135 ++LS+ MML+ +GL E A ++AA+ K LA G TGDL Sbjct: 298 MVLSAAMMLR-IGLKQTEAAADLEAAVDKVLAAGFR-TGDL 336
>Q8NVJ0:LEU3_STAAW 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain MW2)| Length = 348 Score = 134 bits (336), Expect = 1e-30 Identities = 107/341 (31%), Positives = 176/341 (51%), Gaps = 20/341 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQ---SVKDIYSAA---NVPIKWESIDVTPSLNADGKTVIPDESI 352 Y + + GDGIGPEI S+ +I S N I+ S++ G+ + ++++ Sbjct: 3 YNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGA-SIDTFGEP-LTEKTL 60 Query: 353 ASIKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 + KR L G + P + L L LR++ NLFAN+RP ++G + Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGL-LKLRKSLNLFANIRPTTVVKGASSLSPLK 119 Query: 503 --PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 + D V++RE T G Y G + TRE ER++ AF+ A + Sbjct: 120 EERVEGKDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLAAS-RRG 178 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 K+ V K ++ S L+ + E+++ YP + + L+D + ++T+P ++ V+V Sbjct: 179 KLTSVDKENVLASSK-LWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFD--VIVC 235 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 NL+GDILSD + + G LGL+PS + D ++E +HGSAPDIAGK +ANP ++LS Sbjct: 236 ENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSL 295 Query: 1034 IMML-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 M L + + + A++++ I+ + G+T T DLGGK T Sbjct: 296 AMCLRESLNQPDAADELEQHIYNMIEHGQT-TADLGGKLNT 335
>Q65V05:LEU3_MANSM 3-isopropylmalate dehydrogenase - Mannheimia succiniciproducens| (strain MBEL55E) Length = 358 Score = 134 bits (336), Expect = 1e-30 Identities = 112/352 (31%), Positives = 170/352 (48%), Gaps = 33/352 (9%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKDI-----------------YSAANVPIKWESIDVTPSLN 316 Y V+++ GDGIGPE+ A+++K + A + K E + Sbjct: 4 YNVAVLPGDGIGPEVMAEAIKVLDKVQAKFGFKLNFTQYLVGGAAIDAKGEPLPAETLQG 63 Query: 317 ADGKTVIPDESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY 496 D I S+ K ++ P + L LR+ F LF N+RP +G Sbjct: 64 CDNADAILFGSVGGPKWTHLP-------PDQQPERGALLPLRKHFKLFCNLRPATLYKGL 116 Query: 497 KT--------PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVL 637 + D V++RE T G Y G + DG + E ER+ Sbjct: 117 EKFCPLRADIAAKGFDMVVVRELTGGIYFG-QPKGRDGEGSDTRAFDTEVYYKYEIERIA 175 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVV 817 R AF A K +V V KA +++ S L+ EIAKEYP ++ + +DNA ++++ Sbjct: 176 RAAFDAAMKRRK-QVTSVDKANVLQSSI-LWRETVAEIAKEYPEVQVENMYIDNATMQLI 233 Query: 818 TDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAG 994 P ++ VL+ N++GDI+SD A + G +G+ PS ++ +E ++E GSAPDIAG Sbjct: 234 KAPESFD--VLLCSNIFGDIISDEAAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAG 291 Query: 995 KGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKS 1147 KG+ANP A +LS+ MML++ L E A I+ A+ K LA+G TGDL S Sbjct: 292 KGIANPIAQILSAAMMLRYSFNLNEAATAIENAVQKVLADGHR-TGDLADNS 342
>Q2YUF1:LEU3_STAAB 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain| bovine RF122) Length = 348 Score = 133 bits (335), Expect = 2e-30 Identities = 107/341 (31%), Positives = 175/341 (51%), Gaps = 20/341 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQ---SVKDIYSAA---NVPIKWESIDVTPSLNADGKTVIPDESI 352 Y + + GDGIGPEI S+ +I S N I+ S++ G+ + ++++ Sbjct: 3 YNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGA-SIDTFGEP-LTEKTL 60 Query: 353 ASIKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 + KR L G + P + L L LR++ NLFAN+RP +G + Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGL-LKLRKSLNLFANIRPTTVFKGASSLSPLK 119 Query: 503 --PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 + D V++RE T G Y G + TRE ER++ AF+ A + Sbjct: 120 QERVEGTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLAAS-RRG 178 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 K+ V K ++ S L+ + E+++ YP + + L+D + ++T+P ++ V+V Sbjct: 179 KLTSVDKENVLASSK-LWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFD--VIVC 235 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 NL+GDILSD + + G LGL+PS + D ++E +HGSAPDIAGK +ANP ++LS Sbjct: 236 ENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSL 295 Query: 1034 IMML-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 M L + + + A++++ I+ + G+T T DLGGK T Sbjct: 296 AMCLRESLNQPDAADELEQHIYNMIENGQT-TADLGGKLNT 335
>Q2NVW4:LEU3_SODGM 3-isopropylmalate dehydrogenase - Sodalis glossinidius (strain| morsitans) Length = 364 Score = 133 bits (335), Expect = 2e-30 Identities = 103/342 (30%), Positives = 177/342 (51%), Gaps = 25/342 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ I A NV I DV + + +P ++A Sbjct: 6 YHIAVLPGDGIGPEVMAQAYKILDAVRQRFNVRISTSEYDVGGAAIDRQGSPLPAGTVAG 65 Query: 359 IKRNYVALKGPLATPIGKGHVSLN-------LTLRRTFNLFANVRPCK---SIQGYKTPY 508 ++ L G + P + + L LR+ F LF+N+RP + ++ Y Sbjct: 66 CEQADAILFGSVGGPKWEHLPAAEQPERGALLPLRKHFKLFSNLRPSRLYPGLEAYCPLR 125 Query: 509 DNV-----DTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQ 661 N+ D + +RE T G Y G E ++ R ER+ R AF+ A+ Sbjct: 126 ANIAERGFDILCVRELTGGIYFGQPKGREGTGPHEHAFDTEVYYRFEIERIARIAFESAR 185 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 + KV + KA +++ S L+ + ++A +YP++ +DNA ++++ DP+ ++ Sbjct: 186 K-RRGKVTSIDKANVLQSSI-LWRKVVSQVAPDYPDVALSHLYIDNATMQLIKDPSQFD- 242 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTA 1018 V++ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP A Sbjct: 243 -VMLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGMYEPAGGSAPDIAGKDIANPVA 301 Query: 1019 LLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGG 1141 +LS+ ++L++ +GL + A+ I+ A+ + L G T DL G Sbjct: 302 QILSASLLLRYSLGLDDAADAIELAVNQALEAGHR-TADLAG 342
>Q47WG3:LEU3_COLP3 3-isopropylmalate dehydrogenase - Colwellia psychrerythraea (strain| 34H / ATCC BAA-681) (Vibrio psychroerythus) Length = 362 Score = 133 bits (335), Expect = 2e-30 Identities = 106/343 (30%), Positives = 169/343 (49%), Gaps = 30/343 (8%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIASIK 364 ++++ GDGIGPE+ K + + + I + D+ + + +PD ++A Sbjct: 4 IAILAGDGIGPEVMVEAKKVLNTVASKFDFEITTQDYDIGGAAIDNHGNALPDSTMAGCI 63 Query: 365 RNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCK---SIQGYKTPYDN 514 + L G + P + L LR F+LF N+RP ++ T + Sbjct: 64 ESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLSTLRSD 123 Query: 515 V-----DTVLIRENTEGEY---------SGIEHVVVDGVVQSIKLITREASERVLRFAFQ 652 + D ++IRE T Y G E D + S R +R+ AFQ Sbjct: 124 ISEQGFDVLVIRELTGDIYFGEPKGRRGEGEEETGFDSMFYS-----RREVKRISHLAFQ 178 Query: 653 YAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTP 832 AQ KV V KA ++ S L+ + E+A EYP++E + +DNA +++V DP Sbjct: 179 AAQKRNN-KVTSVDKANVLATSQ-LWRQVVEEVAVEYPDVELEHLYVDNAAMQLVRDPNQ 236 Query: 833 YNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNI-GDECSIFEAVHGSAPDIAGKGLAN 1009 ++ V++ PNL+GDILSD+CA + G +GL PS ++ D ++E GSAPDIAG G+AN Sbjct: 237 FD--VMLCPNLFGDILSDICAMITGSMGLLPSASLNSDGFGMYEPAGGSAPDIAGLGVAN 294 Query: 1010 PTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 P A +LS+ +ML++ + A I+ A+ L G +T DL Sbjct: 295 PIAQILSAALMLRYSLNQGAAAKAIEDAVSNALDNG-VLTADL 336
>Q9EVE1:LEU3_BUCUD 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Uroleucon rudbeckiae Length = 363 Score = 133 bits (335), Expect = 2e-30 Identities = 104/367 (28%), Positives = 184/367 (50%), Gaps = 34/367 (9%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIA 355 KY ++++ GDGIGPE+ + I + ++P++ ++ S T +P +++ Sbjct: 4 KYRIAVLPGDGIGPEVMREAYKILNILKNHFSLPLETREFNIGGSAIDQEGTALPKKTLL 63 Query: 356 SIKRNYVALKGPLA------TPIGKGHVSLNLT-LRRTFNLFANVRPCK--SIQGYKTPY 508 + + L G + PI + +L LR+ FNLFAN+RP K S Y +P Sbjct: 64 GCENSDAILFGSVGGKKWDDLPINQRPERASLLPLRKHFNLFANLRPAKLYSELKYLSPL 123 Query: 509 ------DNVDTVLIRENTEGEYSG----------IEHVVVDGVVQSIKLITREASERVLR 640 + D + IRE T G Y G IE+ + + ++ R+ Sbjct: 124 RSDIIKNGFDILCIRELTGGLYFGKPTGRLKKNNIEYAFDTEIYYNYEIT------RIAH 177 Query: 641 FAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVT 820 AFQ AQ K+ + K+ ++ S L+ + ++++K YP++ +DNA ++++ Sbjct: 178 LAFQLAQTRNF-KICSIDKSNVLN-SSVLWREIVKKVSKNYPDVHLSHLYIDNATMQIIK 235 Query: 821 DPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAPDIAGK 997 DP ++ +L+ NL+GDI+SD CA + G +G+ PS ++ + + ++E GSAPDI GK Sbjct: 236 DPNQFD--ILLCSNLFGDIISDECAIITGSIGMLPSASLNEKKFGLYEPAGGSAPDIEGK 293 Query: 998 GLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKS---KTHEYA 1165 +ANP A +LS M++++ M L A+KI ++ L +G T D+ + KT+E Sbjct: 294 NIANPIAQILSVSMLVRYGMNLKTIADKIDQSVISVLKKGYR-TADISNNNNYLKTNEMG 352 Query: 1166 AAVIKNL 1186 + L Sbjct: 353 DVIANTL 359
>Q5HEE3:LEU3_STAAC 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain COL)| Length = 348 Score = 133 bits (334), Expect = 2e-30 Identities = 106/341 (31%), Positives = 175/341 (51%), Gaps = 20/341 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQ---SVKDIYSAA---NVPIKWESIDVTPSLNADGKTVIPDESI 352 Y + + GDGIGPEI S+ +I S N I+ S++ G+ + ++++ Sbjct: 3 YNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGA-SIDTFGEP-LTEKTL 60 Query: 353 ASIKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 + KR L G + P + L L LR++ NLF N+RP ++G + Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGL-LKLRKSLNLFVNIRPTTVVKGASSLSPLK 119 Query: 503 --PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 + D V++RE T G Y G + TRE ER++ AF+ A + Sbjct: 120 EERVEGTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLAAS-RRG 178 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 K+ V K ++ S L+ + E+++ YP + + L+D + ++T+P ++ V+V Sbjct: 179 KLTSVDKENVLASSK-LWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFD--VIVC 235 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 NL+GDILSD + + G LGL+PS + D ++E +HGSAPDIAGK +ANP ++LS Sbjct: 236 ENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSL 295 Query: 1034 IMML-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 M L + + + A++++ I+ + G+T T DLGGK T Sbjct: 296 AMCLRESLNQPDAADELEQHIYSMIEHGQT-TADLGGKLNT 335
>Q2FF66:LEU3_STAA3 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain| USA300) Length = 348 Score = 133 bits (334), Expect = 2e-30 Identities = 106/341 (31%), Positives = 175/341 (51%), Gaps = 20/341 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQ---SVKDIYSAA---NVPIKWESIDVTPSLNADGKTVIPDESI 352 Y + + GDGIGPEI S+ +I S N I+ S++ G+ + ++++ Sbjct: 3 YNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGA-SIDTFGEP-LTEKTL 60 Query: 353 ASIKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 + KR L G + P + L L LR++ NLF N+RP ++G + Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGL-LKLRKSLNLFVNIRPTTVVKGASSLSPLK 119 Query: 503 --PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 + D V++RE T G Y G + TRE ER++ AF+ A + Sbjct: 120 EERVEGTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLAAS-RRG 178 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 K+ V K ++ S L+ + E+++ YP + + L+D + ++T+P ++ V+V Sbjct: 179 KLTSVDKENVLASSK-LWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFD--VIVC 235 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 NL+GDILSD + + G LGL+PS + D ++E +HGSAPDIAGK +ANP ++LS Sbjct: 236 ENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSL 295 Query: 1034 IMML-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 M L + + + A++++ I+ + G+T T DLGGK T Sbjct: 296 AMCLRESLNQPDAADELEQHIYSMIEHGQT-TADLGGKLNT 335
>Q8ZIG9:LEU3_YERPE 3-isopropylmalate dehydrogenase - Yersinia pestis| Length = 363 Score = 132 bits (333), Expect = 3e-30 Identities = 106/358 (29%), Positives = 176/358 (49%), Gaps = 28/358 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ + A + I DV + + +P ++A Sbjct: 5 YHIAVLPGDGIGPEVMAQASKVLDAVRQRFGLKISTSVYDVGGAAIDRHGSPLPAATVAG 64 Query: 359 IKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 ++ L G + P + L LR+ F LF+N+RP + QG + Sbjct: 65 CEQADAILFGSVGGPKWEHLPPAEQPERGALLPLRKHFKLFSNLRPARLYQGLEDFCPLR 124 Query: 503 ---PYDNVDTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQ 661 D + +RE T G Y G E + ++ R ER+ R AF+ A+ Sbjct: 125 SDIAARGFDILCVRELTGGIYFGQPKGREGQGMHERAFDTEVYHRFEIERIARIAFESAR 184 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 + KV + KA +++ S L+ + IA +YP++ +DNA ++++ DP+ ++ Sbjct: 185 K-RRSKVTSIDKANVLQSSI-LWREVVNGIAADYPDVALSHMYIDNATMQLIKDPSQFD- 241 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTA 1018 VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP A Sbjct: 242 -VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 Query: 1019 LLLSSIMMLQ-HMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSK---THEYAAAVIK 1180 +LS ++L+ +G + A+ I+ AI + L +G T DL G THE + K Sbjct: 301 QILSLTLLLRFSLGKDDAADAIERAINQALEQGYR-TADLAGDGHAIGTHEMGDIIAK 357
>Q8RDK0:LEU3_THETN 3-isopropylmalate dehydrogenase - Thermoanaerobacter tengcongensis| Length = 355 Score = 132 bits (333), Expect = 3e-30 Identities = 107/346 (30%), Positives = 168/346 (48%), Gaps = 30/346 (8%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAAN-----------VPIKWESIDVTPSLNADGKTVI 337 Y ++++ GDGIGPE+ + + A P E+ID Sbjct: 2 YRIAVLPGDGIGPEVIEEGLKVLKAVEEKYGLRFDIKKYPFGGEAIDKYGE-------PY 54 Query: 338 PDESIASIKRNYVALKGPLATPIGKGHVSLN------LTLRRTFNLFANVRPCKSIQGYK 499 P+E+ + L G + P G L LR++ ++AN+RP K Sbjct: 55 PEETRNGCLSSDAVLLGAVGGPKWDGLEGDKRPEAGLLALRKSLGVYANLRPAVLYPSLK 114 Query: 500 --TPYDN------VDTVLIRENTEGEYSGIEHVVVDGV---VQSIKLITREASERVLRFA 646 +P N +D +++RE T G Y G G ++ + ER+ A Sbjct: 115 DASPLKNELLEKGLDILVVRELTGGIYFGPRGKEAIGYGFRAYDTEVYETQEIERIAVIA 174 Query: 647 FQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDP 826 F+ A K K+ V KA +++ S L+ E+AK YP +E + +DN +++V +P Sbjct: 175 FEAALRRRK-KITSVDKANVLE-SSRLWRKTVEEVAKRYPEVELNHMYVDNCAMQLVKNP 232 Query: 827 TPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNI-GDECSIFEAVHGSAPDIAGKGL 1003 ++ V++ N++GDILSD A ++G +G+ PS ++ GD ++E +HGSAPDIAGK + Sbjct: 233 FQFD--VILTNNMFGDILSDEAAQIVGSIGILPSASLRGDRVGLYEPIHGSAPDIAGKKI 290 Query: 1004 ANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLG 1138 ANP A +LS MMLQ+ G E A I+ A+ + L EG T DLG Sbjct: 291 ANPLATILSVAMMLQYSFGEEEAAQDIRKAVERALEEGFR-TADLG 335
>Q97EE2:LEU3_CLOAB 3-isopropylmalate dehydrogenase - Clostridium acetobutylicum| Length = 357 Score = 132 bits (333), Expect = 3e-30 Identities = 108/341 (31%), Positives = 171/341 (50%), Gaps = 25/341 (7%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTV------IPDES 349 +Y V++I GDGIG EI + V K+++ + A G + +P+E+ Sbjct: 3 EYKVAVIPGDGIGVEIVGEALKVLE--KVGAKYDTKFNFTEVKAGGCAIDEFGVPLPNET 60 Query: 350 IASIKRNYVALKGPLATPIG------KGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYD 511 + K + L G + P K + LR L+AN+RP K K+ Sbjct: 61 LEICKNSDAVLLGAVGGPKWDTLPGEKRPEKALMGLRGGLGLYANLRPAKVYDILKSASP 120 Query: 512 --------NVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITR---EASERVLRFAFQYA 658 VD +++RE T G Y G + + S R E +R+ AF+ A Sbjct: 121 LKEEIINKGVDLLVVRELTGGIYFGERGRDIQNGINSAYDTERYNVEEIKRIAHVAFKAA 180 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 K KV V KA I++ S L+ E+AKEYP +E + +DNA +++V +P+ ++ Sbjct: 181 LKRNK-KVTSVDKANILE-SSRLWRETVTEVAKEYPEVELNYLYVDNAAMQLVREPSQFD 238 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNI-GDECSIFEAVHGSAPDIAGKGLANPT 1015 V+V N++GDIL+D + + G +G+ PS ++ D ++E +HGSAPDIAG+ LANP Sbjct: 239 --VIVTSNIFGDILTDEASMVTGSIGMLPSASLRNDTFGMYEPIHGSAPDIAGQDLANPL 296 Query: 1016 ALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS MML++ + E A ++ A+ K L G TGD+ Sbjct: 297 AQILSVAMMLEYSFNMTEAARDVEDAVEKVLNSGYR-TGDI 336
>Q1QUR0:LEU3_CHRSD 3-isopropylmalate dehydrogenase - Chromohalobacter salexigens (strain| DSM 3043 / ATCC BAA-138 / NCIMB 13768) Length = 359 Score = 132 bits (333), Expect = 3e-30 Identities = 106/329 (32%), Positives = 169/329 (51%), Gaps = 23/329 (6%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESID--VTPSLNADGKTV-IPDESIASIKR 367 + ++ GDGIGPEI + I +A SI+ + D V +PDE++AS K Sbjct: 5 ILVLPGDGIGPEITREAVKILNACREAGLEASIEEGLVGGAGIDAHGVPLPDETLASAKA 64 Query: 368 NYVALKGPLATP-------IGKGHVSLNLTLRRTFNLFANVRPC------KSIQGYKTPY 508 L G + P + K L LR+ NLF N+RP S K Sbjct: 65 ADAVLLGAVGGPQWDKIEDLSKRPEKGLLGLRKNLNLFGNLRPALLYPQLASASSLKPEI 124 Query: 509 -DNVDTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGK 673 +D +++RE T G Y GIE + V + + ER+ R AF+ A++ G Sbjct: 125 VAGLDIMIVRELTGGIYFGQPRGIEERDGERVGYNTYIYAEHEIERIGRVAFEMARERGG 184 Query: 674 PKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLV 853 K+ V KA +++ + L+ + +A EYP++ +DNA +++V P ++ V+V Sbjct: 185 -KLCSVDKANVLEATI-LWREVMERLAPEYPDVALSHMYVDNAAMQLVRAPKQFD--VIV 240 Query: 854 MPNLYGDILSDMCAGLIGGLGLTPSGNIGDECS-IFEAVHGSAPDIAGKGLANPTALLLS 1030 N++GDILSD A L G +G+ PS ++ ++ ++E HGSAPDIAG+G+ANP A +LS Sbjct: 241 TGNMFGDILSDAAAMLTGSIGMLPSASLNEQRQGMYEPCHGSAPDIAGQGIANPLATILS 300 Query: 1031 SIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 MML++ + + A +I+ A+ L +G Sbjct: 301 VAMMLRYSLEAPQLAERIERAVGTVLDQG 329
>O85071:LEU3_BUCDN 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Diuraphis noxia Length = 363 Score = 132 bits (333), Expect = 3e-30 Identities = 101/338 (29%), Positives = 172/338 (50%), Gaps = 29/338 (8%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIA 355 +Y ++++ GDGIGPE+ Q I ++ IK + D+ + +P +++ Sbjct: 4 QYHIAVLPGDGIGPEVMQEAYKILQVLREHFSLFIKTKEFDIGGIAIDNHGIALPKKTLI 63 Query: 356 SIKRNYVALKGPLA------TPIGKGHVSLNLT-LRRTFNLFANVRPCKSIQ--GYKTPY 508 + + L G + PI + +L LR+ FN F N+RP + + +P Sbjct: 64 GCENSDAILLGSIGGKKWDTLPINERPERASLLPLRKHFNFFCNLRPSNLYKELNFLSPL 123 Query: 509 DN------VDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASE--------RVLRFA 646 N D + +RE T G Y G G V KL+ +E R+ A Sbjct: 124 RNDIVKHGFDILCVRELTGGIYFGKPR----GRVTKKKLMYAFDTEIYYKFEIVRIAHLA 179 Query: 647 FQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDP 826 F+ A+ K K+ + KA +++ S L+ + E++KEYP++ +DN C++++ DP Sbjct: 180 FKLARS-RKHKLCSIDKANVLESSI-LWREVVEEVSKEYPDVILSHLYIDNVCMQIIKDP 237 Query: 827 TPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGL 1003 ++ VL+ NL+GDI+SD CA + G +G+ PS ++ ++ ++E GSAPDI GK + Sbjct: 238 NQFD--VLLCSNLFGDIISDECAMITGSIGMLPSASLNEKNFGLYEPAGGSAPDIQGKNI 295 Query: 1004 ANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 ANP A +LS M++++ M L + ANKI A+ L +G Sbjct: 296 ANPIAQILSLSMLIRYSMNLNKIANKIDNAVINVLKKG 333
>P29102:LEU3_BRANA 3-isopropylmalate dehydrogenase, chloroplast precursor - Brassica| napus (Rape) Length = 406 Score = 132 bits (333), Expect = 3e-30 Identities = 103/358 (28%), Positives = 183/358 (51%), Gaps = 31/358 (8%) Frame = +2 Query: 155 AAFQGQKGSDGKYTVSLIEGDGIGPEIAQSVKDI-----------YSAANVPIKWESIDV 301 AA G+K +Y ++L+ GDGIGPE+ K++ +S +P+ ++D+ Sbjct: 36 AASPGKK----RYNITLLPGDGIGPEVISIAKNVLQQAGSLEGLEFSFQEMPVGGAALDL 91 Query: 302 TPSLNADGKTVIPDESIASIKRNYVALKGPLAT---PIGKGHVSLN---LTLRRTFNLFA 463 +P+E++++ K + L G + + H+ L LR +FA Sbjct: 92 VG-------VPLPEETVSAAKESDAVLLGAIGGYKWDKNEKHLKPETGLLQLRAGLKVFA 144 Query: 464 NVRPCKSIQGY-------KTPYDNVDTVLIRENTEGEYSGIEHVVV-----DGVVQSIKL 607 N+RP + + + VD +++RE T G Y G+ + + V + ++ Sbjct: 145 NLRPATVLPQLVDASTLKREVAEGVDLMVVRELTGGIYFGVPRGIKTNENGEEVGYNTEV 204 Query: 608 ITREASERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAE 787 +R+ R AF+ A+ + K+ V KA ++ S L+ +A EYP++E Sbjct: 205 YAAHEIDRIARVAFETARK-RRGKLCSVDKANVLDASI-LWRRRVTALAAEYPDVELSHM 262 Query: 788 LLDNACLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEA 964 +DNA +++V DP ++ +V N++GDILSD + + G +G+ PS ++ D +FE Sbjct: 263 YVDNAAMQLVRDPKQFD--TIVTNNIFGDILSDEASMITGSIGMLPSASLSDSGPGLFEP 320 Query: 965 VHGSAPDIAGKGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 +HGSAPDIAG+ ANP A +LS+ M+L++ +G + A +I+ A+ L +G TGD+ Sbjct: 321 IHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVLGALNKGFR-TGDI 377
>P93832:LEU32_ARATH 3-isopropylmalate dehydrogenase 2, chloroplast precursor -| Arabidopsis thaliana (Mouse-ear cress) Length = 405 Score = 132 bits (333), Expect = 3e-30 Identities = 110/391 (28%), Positives = 193/391 (49%), Gaps = 31/391 (7%) Frame = +2 Query: 56 AAPARQCMRTARLQHISRPAFQIVQSRFASSQVAAFQGQKGSDGKYTVSLIEGDGIGPEI 235 AA + +RT ++ R + + F A G+K +YT++L+ GDGIGPE+ Sbjct: 2 AAALQTNIRTVKVPATFRAVSKQSLAPFRVRCAVASPGKK----RYTITLLPGDGIGPEV 57 Query: 236 AQSVKDIYSAAN-----------VPIKWESIDVTPSLNADGKTVIPDESIASIKRNYVAL 382 K++ A +PI ++D+ +P+E+I++ K + L Sbjct: 58 VSIAKNVLQQAGSLEGVEFNFREMPIGGAALDLVG-------VPLPEETISAAKESDAVL 110 Query: 383 KGPLAT---PIGKGHVSLN---LTLRRTFNLFANVRPCKSIQGY-------KTPYDNVDT 523 G + + H+ L +R +FAN+RP + + + VD Sbjct: 111 LGAIGGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPATVLPQLVDASTLKREVAEGVDL 170 Query: 524 VLIRENTEGEYSGIEHVVV-----DGVVQSIKLITREASERVLRFAFQYAQDIGKPKVRV 688 +++RE T G Y G + + V + ++ +R+ R AF+ A+ + K+ Sbjct: 171 MVVRELTGGIYFGEPRGIKTNENGEEVGFNTEVYAAHEIDRIARVAFETARK-RRGKLCS 229 Query: 689 VHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVMPNLY 868 V KA +++ S L+ +A EYP++E +DNA +++V DP ++ +V N++ Sbjct: 230 VDKANVLEASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFD--TIVTNNIF 286 Query: 869 GDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTALLLSSIMML 1045 GDILSD + + G +G+ PS ++ D +FE +HGSAPDIAG+ ANP A +LS+ M+L Sbjct: 287 GDILSDEASMITGSIGMLPSASLSDSGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLL 346 Query: 1046 QH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 ++ +G + A +I+ A+ L G TGD+ Sbjct: 347 KYGLGEEKAAKRIEDAVLVALNNGFR-TGDI 376
>Q3AIH4:LEU3_SYNSC 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain CC9605)| Length = 357 Score = 132 bits (332), Expect = 3e-30 Identities = 112/341 (32%), Positives = 180/341 (52%), Gaps = 25/341 (7%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPS-LNADGKTVIPDESI 352 ++ V L+ GDGIGPEI + + + + +E + S ++A G+ +P ++ Sbjct: 3 QHRVVLLPGDGIGPEITAVARQLLEVVSRRHGFSLSFEEQPIGGSAIDATGEP-LPASTL 61 Query: 353 ASIKRNYVALKGPLATPI------GKGHVSLNLTLRRTFNLFANVRPCKSIQGY------ 496 + K L + +P K + L LR LFAN+RP K + Sbjct: 62 DACKAADAVLLAAIGSPCFDSLPREKRPETGLLGLRAGMELFANLRPVKIVPALIDASSL 121 Query: 497 -KTPYDNVDTVLIRENTEGEYSGIE--HVVVDGVVQSIKLITREASE--RVLRFAFQYAQ 661 + + VD +++RE T G Y G + +G + +T ASE R+ + AF+ AQ Sbjct: 122 KREVIEGVDLMVVRELTGGIYFGQPKGRIETEGDERGFNTMTYSASEVDRIAKVAFEIAQ 181 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 + + ++ V KA ++ +S L+ + +A Y +E +DNA +++V DP ++ Sbjct: 182 E-RRGRLCSVDKANVLDVSQ-LWRDRVDAMAPSYGPVEVSHMYVDNAAMQLVRDPRQFD- 238 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTA 1018 VL+ NL+GDILSD A L G +G+ PS ++G E +FE VHGSAPDIAG+ ANP A Sbjct: 239 -VLLTGNLFGDILSDEAAMLTGSIGMLPSASLGSEGPGLFEPVHGSAPDIAGQDKANPMA 297 Query: 1019 LLLSSIMMLQHMGLFE--HANKIQAAIFKTLAEGKTITGDL 1135 ++LS+ MML+ +GL + A+ ++AA+ LA G TGDL Sbjct: 298 MVLSAAMMLR-IGLKQAAAADDLEAAVDAVLAGGFR-TGDL 336
>Q8A6M0:LEU3_BACTN 3-isopropylmalate dehydrogenase - Bacteroides thetaiotaomicron| Length = 353 Score = 132 bits (332), Expect = 3e-30 Identities = 98/326 (30%), Positives = 164/326 (50%), Gaps = 19/326 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWE-SIDVTPSLNADGKTVIPDESIA 355 + ++++ GDGIGPEI+ D+ SA + +E +I +++ G P+E+ Sbjct: 3 FKIAVLAGDGIGPEISVQGVDVMSAVCEKFGHKVSYEYAICGADAIDKVGDP-FPEETYE 61 Query: 356 SIKRNYVALKGPLATPIGKGHVSLN-------LTLRRTFNLFANVRPCKSIQG--YKTPY 508 K L + P + L +R+ LFAN+RP ++ + +K+P Sbjct: 62 VCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLIHKSPL 121 Query: 509 -----DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGK 673 +N D + IRE T G Y G ++ D + TR ER+L+ AF+YA K Sbjct: 122 RAELVENADFICIRELTGGMYFGEKYQDNDKAYDT-NYYTRPEIERILKVAFEYAMKRRK 180 Query: 674 PKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLV 853 + VV KA ++ S L+ + +E+A YP + D +DNA +K++ +P ++ V+V Sbjct: 181 -HLTVVDKANVLA-SSRLWRQIAQEMAPNYPEVTTDYMFVDNAAMKMIQEPAFFD--VMV 236 Query: 854 MPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 N +GDIL+D + + G +GL PS + G+ +FE +HGS P G +ANP A +LS Sbjct: 237 TENTFGDILTDEGSVISGSMGLLPSASTGESTPVFEPIHGSWPQAKGLNIANPLAQILSV 296 Query: 1034 IMMLQHMGLFEHANKIQAAIFKTLAE 1111 M+ ++ E I+ A+ +L E Sbjct: 297 AMLFEYFDCKEEGALIRKAVDASLDE 322
>Q2S0M8:LEU3_SALRD 3-isopropylmalate dehydrogenase - Salinibacter ruber (strain DSM| 13855) Length = 365 Score = 132 bits (331), Expect = 4e-30 Identities = 98/328 (29%), Positives = 160/328 (48%), Gaps = 20/328 (6%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVI-------PDES 349 Y ++ + GDGIGPE+ + + A VT + + G + PD + Sbjct: 7 YDIAWLPGDGIGPEVTREALRVLEAVGSA---HGFSVTATEHRMGGVALDETGMPLPDST 63 Query: 350 IASIKRNYVALKGPLATPIGKGHV------SLNLTLRRTFNLFANVRPCK--SIQGYKTP 505 + + L G + P + S L LR+ ++AN+RP + + +P Sbjct: 64 RDACLESDAVLLGAVGGPKWADNTGDQRPESGLLALRKALGVYANLRPVRVPAALADASP 123 Query: 506 Y-----DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIG 670 D + +RE T G Y G D +S + + ER+ AFQ A+ Sbjct: 124 LRPDRVGGTDILFVRELTGGIYFGTPEGRTDDGARSTMAYSDDEIERIAHVAFQRARR-R 182 Query: 671 KPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVL 850 V V KA ++++S+ L+ + E+ + P++ +DNA ++VV DP ++ V+ Sbjct: 183 DGNVTSVDKANVLEVSE-LWREVVTEVHDDCPDVTLRHLYVDNAAMQVVRDPRQFD--VV 239 Query: 851 VMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLS 1030 + NL+GDILSD+ A L G LGL PS ++G +FE VHGSAPDIAG+ +ANPTA +LS Sbjct: 240 LTGNLFGDILSDLAAALPGSLGLLPSASVGGTVGLFEPVHGSAPDIAGQDVANPTAAILS 299 Query: 1031 SIMMLQHMGLFEHANKIQAAIFKTLAEG 1114 + ++L +G A+ ++ + L G Sbjct: 300 AALLLDEVGETAAADAVRHGVDAALDAG 327
>Q2RGA0:LEU3_MOOTA 3-isopropylmalate dehydrogenase - Moorella thermoacetica (strain ATCC| 39073) Length = 357 Score = 132 bits (331), Expect = 4e-30 Identities = 98/331 (29%), Positives = 166/331 (50%), Gaps = 23/331 (6%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAAN--VPIKWESIDVT---PSLNADGKTVIPDESIA 355 Y ++++ GDGIGPEI + A + V I+++ + +++A G +P E++ Sbjct: 2 YKIAVLPGDGIGPEIVPEAVKVLEAVSRRVGIEFQFTEALVGGAAIDARG-IALPPETLE 60 Query: 356 SIKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY------ 496 +++ L G + P + + L LR+ L+AN+RP Sbjct: 61 LCRQSDAVLLGAVGGPKWDTLPPAERPETAALLPLRKELGLYANLRPAFLYDSLVEASPL 120 Query: 497 -KTPYDNVDTVLIRENTEGEYSGI---EHVVVDGVVQSIKLITREASERVLRFAFQYAQD 664 K D +++RE T G Y G E + TR ER++R AF A+ Sbjct: 121 KKEIVTGTDLIIVRELTGGLYFGAKKREQTAEGEMAYDTMYYTRAEIERIVRLAFTIARQ 180 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 + + V KA ++ S L+ + +I E+P + + +DN +++V P ++ Sbjct: 181 -RRCHLTSVDKANVLTTSR-LWRDTVEDIKGEFPEVTVEHMYVDNCAMQLVRRPAQFD-- 236 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALL 1024 V+V N +GDILSD + L G +G+ PS +IG +++E HGSAPDIAG+ ANP A + Sbjct: 237 VIVTENTFGDILSDQASVLTGSIGMLPSASIGGAVALYEPCHGSAPDIAGQQKANPLATI 296 Query: 1025 LSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 LS+ MML++ + + A I+AA+ + LA+G Sbjct: 297 LSAAMMLKYSFKMDQAAAAIEAAVGRVLAKG 327
>Q6D0G7:LEU3_ERWCT 3-isopropylmalate dehydrogenase - Erwinia carotovora subsp.| atroseptica (Pectobacterium atrosepticum) Length = 363 Score = 132 bits (331), Expect = 4e-30 Identities = 103/345 (29%), Positives = 171/345 (49%), Gaps = 26/345 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ + A + I DV T +P ++A Sbjct: 5 YHIAVLPGDGIGPEVMAQAHKVLDAVRQRFGIRITTSEYDVGGIAIDRQGTPLPQATVAG 64 Query: 359 IKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 ++ L G + P + L LR+ F LF+N+RP + QG + Sbjct: 65 CEQADAILFGSVGGPKWEHLPPAEQPERGALLPLRKHFKLFSNLRPARLYQGLEAFCPLR 124 Query: 503 ---PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQYA 658 D + +RE T G Y G + +G Q + E ER+ AF+ A Sbjct: 125 SDIAAKGFDILCVRELTGGIYFG-QPKGREGSGQYERAFDTEVYHRFEIERIAHIAFESA 183 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 + + V + KA +++ S L+ + E+AK YP+++ +DNA ++++ DP+ ++ Sbjct: 184 RK-RRSIVTSIDKANVLQSSI-LWREIVTEVAKAYPDVKLSHLYIDNATMQLIKDPSQFD 241 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPT 1015 V++ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 242 --VMLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKDIANPI 299 Query: 1016 ALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKS 1147 A +LS ++L++ +G + A I+ A+ LAEG T DL S Sbjct: 300 AQILSLALLLRYSLGADDAAEAIEKAVNTALAEGYR-TADLASAS 343
>Q9ABN3:LEU3_CAUCR 3-isopropylmalate dehydrogenase - Caulobacter crescentus (Caulobacter| vibrioides) Length = 350 Score = 132 bits (331), Expect = 4e-30 Identities = 118/355 (33%), Positives = 178/355 (50%), Gaps = 24/355 (6%) Frame = +2 Query: 194 TVSLIEGDGIGPEIAQSVKDIYSAANVPIKW-ESIDVTPSLNADGKTVIPDESIASIKRN 370 T+ L+ GDGIGPE+ V+ + +A +K E++ S + G T + DE + Sbjct: 3 TLLLLPGDGIGPEVCAQVRRVAAALTPDLKVDEALYGGASYDTHG-TPLTDEVREQALAS 61 Query: 371 YVALKGPLATPI---GKGHVSLN---LTLRRTFNLFANVRPCKSIQGYKTP-------YD 511 L G + P H+ L LR+ ++FAN+RP + Sbjct: 62 DAVLMGAVGGPKWADAPRHLRPEAGLLNLRKAMDVFANLRPAYCFEALAGASSLKPELVS 121 Query: 512 NVDTVLIRENTEGEY----SGIEHVVVDGVVQSI--KLITREASERVLRFAFQYAQDIGK 673 +D + +RE G Y GIE + DG + ++ T ERV R AF+ A+ Sbjct: 122 GLDIMFVRELVGGVYFGQPRGIEDLA-DGQKKGFDTQVYTTSEIERVGRVAFELARGRTN 180 Query: 674 PKVRVVHKATIMKMSDGLFLNLGREI-AKEYPNIEFDAELLDNACLKVVTDPTPYNDKVL 850 KV K+ +M+ S L+ + E+ A+EYP+++ + L DN +++V P ++ V+ Sbjct: 181 -KVHSAEKSNVME-SGLLWKQVITELHAREYPDVQLEHILADNCAMQLVRAPKQFD--VI 236 Query: 851 VMPNLYGDILSDMCAGLIGGLGLTPSGNIG--DECSIFEAVHGSAPDIAGKGLANPTALL 1024 V NL+GDILSD A L G LG+ PS +G + ++E +HGSAPDIAGKGLANP A + Sbjct: 237 VTDNLFGDILSDAAAMLTGSLGMLPSAALGAPGKPGLYEPIHGSAPDIAGKGLANPLAAI 296 Query: 1025 LSSIMMLQ-HMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL 1186 LS M L+ + E A+ + AA+ L G T DLGG T + AV+ L Sbjct: 297 LSFEMALRWSLKQTEAADALLAAVKAALDNGAR-TRDLGGSLTTTQMGDAVLAAL 350
>Q2FWK2:LEU3_STAA8 3-isopropylmalate dehydrogenase - Staphylococcus aureus (strain NCTC| 8325) Length = 348 Score = 131 bits (330), Expect = 6e-30 Identities = 105/341 (30%), Positives = 174/341 (51%), Gaps = 20/341 (5%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQ---SVKDIYSAA---NVPIKWESIDVTPSLNADGKTVIPDESI 352 Y + + GDGIGPEI S+ +I S N I+ S++ G+ + ++++ Sbjct: 3 YNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGA-SIDTFGEP-LTEKTL 60 Query: 353 ASIKRNYVALKGPLA-----TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 + KR L G + P + L L LR++ NLF N+RP ++G + Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGL-LKLRKSLNLFVNIRPTTVVKGASSLSPLK 119 Query: 503 --PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKP 676 + D V++RE T G Y G + TRE ER++ AF+ A + Sbjct: 120 EERVEGTDLVIVRELTSGIYFGEPRHFNNHEALDSLTYTREEIERIVHVAFKLAAS-RRG 178 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 K+ V K ++ S L+ + E+++ YP + + +D + ++T+P ++ V+V Sbjct: 179 KLTSVDKENVLASSK-LWRKVVNEVSQLYPEVTVNHLFVDACSMHLITNPKQFD--VIVC 235 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 NL+GDILSD + + G LGL+PS + D ++E +HGSAPDIAGK +ANP ++LS Sbjct: 236 ENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILSL 295 Query: 1034 IMML-QHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 M L + + + A++++ I+ + G+T T DLGGK T Sbjct: 296 AMCLRESLNQPDAADELEQHIYSMIEHGQT-TADLGGKLNT 335
>Q726X1:LEU3_DESVH 3-isopropylmalate dehydrogenase - Desulfovibrio vulgaris (strain| Hildenborough / ATCC 29579 / NCIMB 8303) Length = 357 Score = 131 bits (330), Expect = 6e-30 Identities = 116/352 (32%), Positives = 177/352 (50%), Gaps = 33/352 (9%) Frame = +2 Query: 197 VSLIEGDGIGPEI-AQSVKDI----------YSAANVPIKWESIDVTPSLNADGKTVIPD 343 + L+ GDGIGPEI AQ K + S ++ I +ID T S +PD Sbjct: 5 ICLLPGDGIGPEIVAQGTKVLDAVARRFGHTVSTSSALIGGAAIDATGS-------PLPD 57 Query: 344 ESIASIKRNYVALKGPLATPIGKGHVSLN------LTLRRTFNLFANVRPCK-------- 481 ++ + + + L G + P S L +R+ LFAN+RP Sbjct: 58 ATVEACRTSDAVLLGAVGGPKWDDLPSEKRPEKGLLGIRKALGLFANLRPAALFPELAGA 117 Query: 482 SIQGYKTPYDNVDTVLIRENTE----GEYSGIEHVVVDGVVQSIKLITREASE--RVLRF 643 + +D V++RE T G+ +GIE DG+ + + E R+ R Sbjct: 118 CLLRADIAAAGLDLVVVRELTGDVYFGQPAGIE--TRDGLRTGFNTMIYDEDEVRRIARV 175 Query: 644 AFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTD 823 AF A+ K +V V KA ++ S L+ + E+A++YP++E +DNA +++V Sbjct: 176 AFDTAR-ARKRRVCSVDKANVLATSR-LWREVVEEVARDYPDVELSHMYVDNAAMQLVRW 233 Query: 824 PTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKG 1000 P ++ V+V NL+GDILSD A + G +G+ PS ++G ++FE +HGSAPDIAG+ Sbjct: 234 PAQFD--VIVTGNLFGDILSDEAAVITGSIGMLPSASMGSGGPALFEPIHGSAPDIAGQD 291 Query: 1001 LANPTALLLSSIMMLQ-HMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 ANP A +LS MML+ GL A+ I AA+ + LAEG TGD+ +T Sbjct: 292 KANPIATILSVGMMLRLGFGLAAEADAIDAAVRRVLAEGYR-TGDIMENGRT 342
>Q7VY73:LEU3_BORPE 3-isopropylmalate dehydrogenase - Bordetella pertussis| Length = 358 Score = 131 bits (330), Expect = 6e-30 Identities = 108/359 (30%), Positives = 184/359 (51%), Gaps = 27/359 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRN 370 + ++++ GDGIGPEI + + + A ++P++ V + + +P ++ + + Sbjct: 3 HQIAVLPGDGIGPEIVEQAERVLKALDLPLELRQAPVGGAAFDQFEHPLPPATLELAQGS 62 Query: 371 YVALKGPLAT------PIGKGHVSLNLTLRRTFNLFANVRPC------KSIQGYKTPY-D 511 + L G + P L LR+ LFAN+RP S K Sbjct: 63 HAVLFGAVGDWKYDTLPREFRPEQAILGLRKALGLFANLRPAILYPELASASSLKPEIVS 122 Query: 512 NVDTVLIRENTEGEYSGIEHVV---VDGVV----QSIKLITREASE--RVLRFAFQYAQD 664 +D ++IRE T Y G V DG + + SE R+ R F+ A+ Sbjct: 123 GLDILIIRELTGDIYFGTPRGVRTAADGAFAGEREGYDTMRYAESEVRRIARIGFESARK 182 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 K K+ V KA +++ S + +L E++++Y ++E +DNA +++V +P ++ Sbjct: 183 RNK-KLCSVDKANVLETSQ-FWRDLVIEVSRDYLDVELSHMYVDNAAMQLVRNPRQFD-- 238 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECS-IFEAVHGSAPDIAGKGLANPTAL 1021 V+V NL+GDILSD A L G +G+ PS ++ ++E HGSAPDIAG+G+ANP A Sbjct: 239 VIVTGNLFGDILSDEAAMLTGSIGMLPSASLNAAGQGLYEPSHGSAPDIAGQGIANPLAT 298 Query: 1022 LLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG-KTITGDLGGKSK--THEYAAAVIKNL 1186 +LS+ M+L++ + L A++++AA+ K LA+G +T G +K T + AV+K L Sbjct: 299 ILSAAMLLRYSLNLAPQADRVEAAVRKVLADGLRTADIHEAGTTKVSTSQMGDAVLKAL 357
>P05644:LEU3_BACCA 3-isopropylmalate dehydrogenase - Bacillus caldotenax| Length = 366 Score = 131 bits (330), Expect = 6e-30 Identities = 108/360 (30%), Positives = 186/360 (51%), Gaps = 22/360 (6%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAANV----PIKWESIDVTPSLNADGKTVIPDESI 352 G Y ++++ GDGIG E+ ++ A + +E + + + T +P+E++ Sbjct: 2 GNYRIAVLPGDGIGKEVTSGAVEVLKAVGIRFGHEFTFEYGLIGGAAIDEAGTPLPEETV 61 Query: 353 ASIKRNYVALKGPLATPI---GKGHVSLN---LTLRRTFNLFANVRP--CKSIQGYKTPY 508 + + L G + P H+ L +R+ +L+AN+RP C ++P Sbjct: 62 RLCRESDAVLLGAVGGPKWDDNPPHLRPEKGLLAIRKQLDLYANLRPVVCYDSLVSRSPL 121 Query: 509 -----DNVDTVLIRENTEGEYSGIEHVVVD-GVVQSIK--LITREASERVLRFAFQYAQD 664 VD V++RE T G Y G VV+ G +++ L +E ER++R AF+ A+ Sbjct: 122 KPDLVQGVDFVIVRELTGGIYFGQPSAVVENGEEKAVDTLLYKKEEIERIVRMAFELARG 181 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 K KV V KA ++ S L+ + E+A E+P++ + L+D ++++ P ++ Sbjct: 182 RRK-KVTSVDKANVLS-SSRLWREVAEEVANEFPDVTLEHMLVDMR-MQLIRAPKQFD-- 236 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTAL 1021 V+V N++GDILSD + L G LG+ PS ++ S++E VHGSAPDIAG ANP A Sbjct: 237 VIVTENMFGDILSDEASMLSGSLGMLPSASLSASGPSLYEPVHGSAPDIAGMNKANPIAA 296 Query: 1022 LLSSIMMLQ-HMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAVIKNL*IAI 1198 +LS+ MML+ GL A +A +++ LA G +G G+ + H +++ + A+ Sbjct: 297 ILSAAMMLRLSFGLTAEAGG-RARVWQALALG---SGSRLGQRRPHLSTNEMVEEIKAAV 352
>P43860:LEU3_HAEIN 3-isopropylmalate dehydrogenase - Haemophilus influenzae| Length = 358 Score = 131 bits (329), Expect = 8e-30 Identities = 106/344 (30%), Positives = 171/344 (49%), Gaps = 25/344 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVK---DIYSAANVPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ A+++K + + + V + +P E++ Sbjct: 4 YNIAVLAGDGIGPEVMAEAIKVLNRVQEKFGFKLNFNEFFVGGAAIEHCGYPLPAETLKG 63 Query: 359 IKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 + L G + P + L LR+ F LF N+RP +G + Sbjct: 64 CDQADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFCPLR 123 Query: 503 ---PYDNVDTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQ 661 D V++RE T G Y G E V ++ + ER+ R AF+ A Sbjct: 124 ADIAAKGFDMVVVRELTGGIYFGQPKGREGDGVQTKAFDTEVYYKYEIERIARAAFEAAM 183 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 K KV V KA +++ S L+ E+AK+YP + + +DNA ++++ P ++ Sbjct: 184 KRNK-KVTSVDKANVLQSSI-LWRETVTEMAKDYPEVTLEHIYIDNATMQLIKSPESFD- 240 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTA 1018 VL+ N++GDI+SD A + G +G+ PS ++ +E ++E GSAPDIAGKG+ANP A Sbjct: 241 -VLLCSNIFGDIISDEAAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKGIANPIA 299 Query: 1019 LLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKS 1147 +LS+ MML++ L E A+ I++A+ K LA G T DL S Sbjct: 300 QILSAAMMLRYSFNLNEAADAIESAVQKVLASGHR-TADLADDS 342
>P59027:LEU3_BUCPS 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Pemphigus spyrothecae Length = 363 Score = 131 bits (329), Expect = 8e-30 Identities = 103/334 (30%), Positives = 177/334 (52%), Gaps = 26/334 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQ---SVKDIYSAANVPIKWESIDVTP-SLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ Q + K + + I D+ +++ GK +P E++ Sbjct: 5 YNLAILPGDGIGPELLQKDLNFKVLKEQYKLKINTTEYDIGGIAIDKYGKA-LPKETLDG 63 Query: 359 IKRNYVALKGPLATPIGKGHVSLN--------LTLRRTFNLFANVRPCK--SIQGYKTPY 508 K + L G + P + H+ + L +R+ FNLF+N+RP K S + +P Sbjct: 64 CKESDSILFGSVGGPKWQ-HLPPDQQPERAALLPIRKYFNLFSNLRPAKLYSTLNHLSPL 122 Query: 509 ------DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITR--EASE--RVLRFAFQYA 658 D + +RE T G Y G + ++ T ASE R+ F+ A Sbjct: 123 RRDISEKGFDILCVRELTGGIYFGKPKGYIKNIIDKKAFDTEIYYASEIKRIAHIGFKLA 182 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 Q+ K K+ V KA +++ S L+ I+KEYP+++ +D+A ++++ +P ++ Sbjct: 183 QN-RKYKITSVDKANVLE-SSVLWRETVNTISKEYPDVKLSHLYIDHAAMQIIKNPDKFD 240 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAPDIAGKGLANPT 1015 V++ NL+GDILSD CA + G +G+ PS ++ D ++E GSAPDIAGK +ANP Sbjct: 241 --VILTSNLFGDILSDECAMITGSIGMLPSASLNDSNFGLYEPAGGSAPDIAGKNIANPI 298 Query: 1016 ALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 A +LS M++++ M L ++ I++A+ TL +G Sbjct: 299 AQILSIAMLVRYTMKLPMISDHIESAVIDTLKKG 332
>O85064:LEU3_BUCAP 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Schizaphis graminum Length = 363 Score = 131 bits (329), Expect = 8e-30 Identities = 102/361 (28%), Positives = 185/361 (51%), Gaps = 37/361 (10%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAANV-------PIKWESIDVTP-SLNADGKTVIPD 343 K+ ++++ GDGIGPE+ +++ Y N+ ++ D+ +++ +G +P+ Sbjct: 4 KFRIAVLPGDGIGPEV---MREAYKILNILERKFFLKLELREFDIGGIAIDREG-IALPE 59 Query: 344 ESIASIKRNYVALKGPLA------TPI-GKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT 502 +++ + + L G + PI + + L LR+ FNLF+N+RP K K Sbjct: 60 KTLRGCENSDAILFGSVGGKKWDYLPIESRPERASLLPLRKHFNLFSNLRPAKLRVDLKN 119 Query: 503 --------PYDNVDTVLIRENTEGEYSGI----------EHVVVDGVVQSIKLITREASE 628 D D + IRE T G Y G E+ + ++ E Sbjct: 120 LSPLRSDIVRDGFDILCIRELTGGIYFGKPKGRFKNKNGEYAFDTEIYYDFEI------E 173 Query: 629 RVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACL 808 R+ AF+ A + KV + KA +++ S L+ + ++++K YP++ +DNAC+ Sbjct: 174 RIANLAFELASS-RRCKVCSIDKANVLE-SSVLWREIVKKVSKNYPDVHLSHLYIDNACM 231 Query: 809 KVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPD 985 +++ +PT ++ +L+ N++GDI+SD CA + G +G+ PS ++ ++ ++E GSAPD Sbjct: 232 QIIKNPTQFD--ILLCSNIFGDIISDECAMITGSIGMLPSASLNNQKFGLYEPAGGSAPD 289 Query: 986 IAGKGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKS--KTH 1156 I GK +ANP A +LS M++++ M L E A+KI ++ L EG GK+ KT+ Sbjct: 290 IEGKNIANPIAQILSLSMLIRYSMNLNEIADKIDLSVHYALKEGYRTLDISDGKNYIKTN 349 Query: 1157 E 1159 E Sbjct: 350 E 350
>Q9SA14:LEU31_ARATH 3-isopropylmalate dehydrogenase 1, chloroplast precursor -| Arabidopsis thaliana (Mouse-ear cress) Length = 404 Score = 131 bits (329), Expect = 8e-30 Identities = 102/347 (29%), Positives = 174/347 (50%), Gaps = 31/347 (8%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAAN-----------VPIKWESIDVTPSLNADGKTV 334 +Y ++L+ GDGIGPE+ K++ A +P ++D+ Sbjct: 43 RYNITLLPGDGIGPEVISVAKNVLQKAGFLQGLEFDFQEMPFGGAALDLVG-------VP 95 Query: 335 IPDESIASIKRNYVALKGPLAT-PIGKGHVSLN-----LTLRRTFNLFANVRPCKSIQGY 496 +P+E+ + K++ L G + K L L +RR N+FAN+RP + Sbjct: 96 LPEETSTAAKQSDAILLGAIGGYKWDKNEKHLRPEMGLLNIRRDLNVFANLRPATVLPQL 155 Query: 497 -------KTPYDNVDTVLIRENTEGEYSGIEHVVV-----DGVVQSIKLITREASERVLR 640 K VD +++RE T G Y G + + V + ++ +R+ R Sbjct: 156 VDASTLKKEVAQGVDMMIVRELTGGIYFGEPRGITINENGEEVGFNTEIYAAHEIDRIAR 215 Query: 641 FAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVT 820 AF+ A+ + K+ V KA ++ S L+ +A EYP++E +DNA +++V Sbjct: 216 VAFETARK-RRGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLVR 273 Query: 821 DPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGK 997 DP ++ +V N++GDILSD + + G +G+ PS ++G+ +FE +HGSAPDIAG+ Sbjct: 274 DPKQFD--TIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQ 331 Query: 998 GLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 ANP A +LS+ M+L++ +G + A I+ A+ L +G TGD+ Sbjct: 332 DKANPLATILSAAMLLKYGLGEEKAAKMIEDAVVDALNKGFR-TGDI 377
>Q39Y29:LEU3_GEOMG 3-isopropylmalate dehydrogenase - Geobacter metallireducens (strain| GS-15 / ATCC 53774 / DSM 7210) Length = 362 Score = 130 bits (328), Expect = 1e-29 Identities = 109/334 (32%), Positives = 170/334 (50%), Gaps = 26/334 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAAN--VPIKWESIDVT---PSLNADGKTVIPDESIA 355 + V+++ GDGIGPE+ + A +K+E ++ +GK +P+ +I Sbjct: 5 FKVAVLPGDGIGPEVMAEALRVLDAIEKKYDVKFERTHANVGGAGIDLEGKA-LPETTIT 63 Query: 356 SIKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPC---KSIQGYKTP 505 K + L G + P + L LR+ F L+AN+RP S+ G + Sbjct: 64 ICKTSDAILFGSVGGPKWETLPPDEQPERGALLPLRKIFGLYANLRPAIIFPSLTGASSL 123 Query: 506 YDNV-----DTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFAFQYA 658 + V + ++IRE T G Y GIE D V + ER+ AFQ A Sbjct: 124 KEEVIAGGFNVLVIRELTGGIYFAQPKGIEGEGRDRVGFDTMRYSVPEIERITHVAFQAA 183 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 + GK KV + KA ++ S L+ + IAKEYP++E +DNA +++V P ++ Sbjct: 184 RKRGK-KVCSIDKANVLS-SSVLWREVVTGIAKEYPDVELSHMYVDNAAMQLVRWPKQFD 241 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPT 1015 V++ N++GDILSD A L G LG+ PS ++ + ++E GSAPDIAG+G+ANP Sbjct: 242 --VILCENMFGDILSDEAAMLTGSLGMLPSASLAEGTFGMYEPSGGSAPDIAGQGIANPI 299 Query: 1016 ALLLSSIMMLQ-HMGLFEHANKIQAAIFKTLAEG 1114 A +LS MML+ G+ + A+ I A+ K L +G Sbjct: 300 AQILSMGMMLRFSFGMVDAADAIDNAVAKVLDQG 333
>Q30WD0:LEU3_DESDG 3-isopropylmalate dehydrogenase - Desulfovibrio desulfuricans (strain| G20) Length = 358 Score = 130 bits (328), Expect = 1e-29 Identities = 106/342 (30%), Positives = 171/342 (50%), Gaps = 29/342 (8%) Frame = +2 Query: 197 VSLIEGDGIGPEIA-QSVKDIYSAANV---PIKWESIDVTPSLNADGKTVIPDESIASIK 364 + L+ GDGIGPEI Q V+ + + A +++ + + + +P E++ + K Sbjct: 5 ICLLAGDGIGPEIMEQGVRVLETVAGKFGHDMEFTDALIGGAAIDETGDPLPQETVEACK 64 Query: 365 RNYVALKGPLATPIGKGHVSLN------LTLRRTFNLFANVRPCKSIQGYKTPY------ 508 L G + P L +R+ LFAN+RP K + Sbjct: 65 AAQAVLLGAVGGPRWDNLTGAERPEAGLLGIRKALGLFANLRPAKLFPELASACFLRPDI 124 Query: 509 --DNVDTVLIRENTEGEYSGIE--HVVVDGVVQSIKLITREASE--RVLRFAFQYAQDIG 670 + +D +++RE T G Y G DG+ + + E R+ R AF+ A+ Sbjct: 125 VANGIDVMVVRELTGGIYFGTPAGEETRDGLRTAFNTMVYNEEEVRRIARVAFEAARK-R 183 Query: 671 KPKVRVVHKATIMKMSDGLFLNLGREI-----AKEYPNIEFDAELLDNACLKVVTDPTPY 835 +V V KA ++ +S L REI A E+P++E +DNA +++V DP+ + Sbjct: 184 SGRVCSVDKANVLAVS-----RLWREIVTATHADEFPDVELSHMYVDNAAMQLVRDPSQF 238 Query: 836 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANP 1012 + V+V NL+GDILSD + + G +G+ PS ++G +FE +HGSAPDIAG+ ANP Sbjct: 239 D--VIVTGNLFGDILSDEASVITGSIGMLPSASLGAGGPGLFEPIHGSAPDIAGQNKANP 296 Query: 1013 TALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS+ MML+H GL + A ++ A+ + L G TGD+ Sbjct: 297 LATILSTAMMLRHSFGLEKEAEAVEGAVQQVLKAGYR-TGDI 337
>Q12545:LEU3_CEPAC 3-isopropylmalate dehydrogenase - Cephalosporium acremonium| (Acremonium chrysogenum) Length = 380 Score = 130 bits (328), Expect = 1e-29 Identities = 117/370 (31%), Positives = 186/370 (50%), Gaps = 38/370 (10%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTP------SLNADGKTV---IPD 343 Y + ++ GD IGPEI + + ++T S++ G + + D Sbjct: 5 YKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTTDLVGGTSIDTHGVPITQSVLD 64 Query: 344 ESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCK----SIQGYKTPYD 511 + AS + ++ GP + S L LR+ + FAN+RPC+ S+ G + Sbjct: 65 AAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGASPIRE 124 Query: 512 NVDT----VLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGKPK 679 +V +++REN G Y G E + V + + TR ER+ R + A+ +G+ + Sbjct: 125 HVVKGTRFIVVRENCGGAYFG-EKKEEEDVASDLWVYTRPEIERLARVSAAVARIMGRSE 183 Query: 680 -------VRVVHKATIMKMSDGLFLNLGREI-AKEYPNIEFDAELLDNACLKVVTDPTPY 835 V KA ++ S L+ + +I AKE+P+I +L D+ + +V DP + Sbjct: 184 DDNQAATVWSADKANVLA-SGRLWRRITSDIFAKEFPDITLQHQLADSMAMLMVRDPRRF 242 Query: 836 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNI------GDECS-IFEAVHGSAPDIAG 994 N V+ N +GDILSD+ + G LGL PS ++ G + I+E VHGSAPDI+G Sbjct: 243 NG-VIHTDNTFGDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGSAPDISG 301 Query: 995 KGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTL---AEG--KTITGDLGGKSKTH 1156 KGLANP A +LS MML++ MGL + A ++ A+ K L +EG + TGDLGG++ Sbjct: 302 KGLANPVAQILSVAMMLRYSMGLEKEATAVERAVVKVLDAKSEGGLEIRTGDLGGRATCS 361 Query: 1157 EYAAAVIKNL 1186 + AV + L Sbjct: 362 QVGDAVCEVL 371
>Q47HR1:LEU31_DECAR 3-isopropylmalate dehydrogenase 1 - Dechloromonas aromatica (strain| RCB) Length = 350 Score = 130 bits (327), Expect = 1e-29 Identities = 113/356 (31%), Positives = 185/356 (51%), Gaps = 26/356 (7%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWE-------SIDVTPSLNADGKTVIPDESIA 355 + ++ GDGIGPEI + ++ ++ + E ++D T + + + + A Sbjct: 3 ICVLPGDGIGPEITAQAVRVLNSLDLKFEMEEALLGGGAVDATGNPYPEATQKLARAADA 62 Query: 356 SIKRNYVALKGPL--ATPIGKGHVSLNLTLRRTFNLFANVRPC---KSIQGYKTPYDNV- 517 + A+ GP + P + L +R+ NLFAN+RP + T V Sbjct: 63 VLLG---AVGGPKWDSLPREQRPERGLLGIRKDLNLFANLRPAILYPELANASTLKPEVV 119 Query: 518 ---DTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLR----FAFQYAQDIGKP 676 D ++IRE T Y G V + + + T SE +R AFQ AQ K Sbjct: 120 AGLDILIIRELTGDIYFGQPRGVREENGERVGFNTMVYSESEIRRIGHVAFQAAQKRDK- 178 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLVM 856 ++ V K +++ + L+ ++ EI+++YP++E L+DNA +++V P ++ V+V Sbjct: 179 RLCSVDKMNVLECTQ-LWRDVMIEISRDYPDVELSHMLVDNAAMQLVKAPKQFD--VMVT 235 Query: 857 PNLYGDILSDMCAGLIGGLGLTPSGNIGDECS-IFEAVHGSAPDIAGKGLANPTALLLSS 1033 N++GDILSD + L G +G+ PS ++ D+ ++E HGSAPDIAGKG+ANP A +LS+ Sbjct: 236 GNMFGDILSDEASMLTGSIGMLPSASLDDKNKGLYEPSHGSAPDIAGKGVANPLATILSA 295 Query: 1034 IMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL----GGKSKTHEYAAAVIKNL 1186 MML++ GL E A +++ A+ K LA+G TGD+ K T E AV+ L Sbjct: 296 AMMLRYTFGLEEQALRVENAVKKVLAQGYR-TGDIYERGTNKVGTREMGDAVLAAL 350
>Q6ANR1:LEU3_DESPS 3-isopropylmalate dehydrogenase - Desulfotalea psychrophila| Length = 357 Score = 130 bits (326), Expect = 2e-29 Identities = 100/331 (30%), Positives = 161/331 (48%), Gaps = 25/331 (7%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDESIASIK 364 ++++ GDGIGPE+ + + A + ++ DV + +P+ ++ Sbjct: 4 IAVLAGDGIGPEVMEQALKVLVAVQKKFGFELSFQHADVGGAAIDSHGVALPESTLTLCA 63 Query: 365 RNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPY----- 508 + L G + P + + L LR+ F+LF N RP + + Sbjct: 64 ESDAILFGSVGGPKWEHLPPAEQPERAALLPLRKHFDLFCNYRPARVFKSLTAACPLRAD 123 Query: 509 ---DNVDTVLIRENTEGEYSGI----EHVVVDGVVQSIKLITREASERVLRFAFQYAQDI 667 D D + +RE T G Y G E D R R+ AF A+ Sbjct: 124 IIGDGFDILCVRELTSGIYFGTPKGREGAGEDEYAYDTMGYKRSEVRRIAHMAFAAARQ- 182 Query: 668 GKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKV 847 KV V KA ++ L+ + E+AKEYP+++ + +DNA +++V DP ++ V Sbjct: 183 RSGKVTSVDKANVLTTMV-LWREVVLEVAKEYPDVKLNHIYVDNATMQLVRDPHQFD--V 239 Query: 848 LVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTALL 1024 ++ N++GDI+SD A L G +GL S ++ E +FE GSAPDIAG+G+ANP A + Sbjct: 240 MLCGNMFGDIISDEAAMLTGSMGLLASASLNTENFGLFEPAGGSAPDIAGQGIANPIAEI 299 Query: 1025 LSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 LS+ MML++ +G E A+ I+AA+ KTL G Sbjct: 300 LSAAMMLRYSLGYGEAADAIEAAVEKTLDRG 330
>Q9EVI1:LEU3_BUCUO 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Uroleucon obscurum Length = 364 Score = 130 bits (326), Expect = 2e-29 Identities = 105/368 (28%), Positives = 182/368 (49%), Gaps = 35/368 (9%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDESIA 355 +Y ++++ GDGIGPE+ + I + + E +V +P +++ Sbjct: 4 QYRIAVLPGDGIGPEVMREAYKILKILKNNFLLSFEIEEFNVGGIAIDQEGLALPKKTLL 63 Query: 356 SIKRNYVALKGPLAT------PIG-KGHVSLNLTLRRTFNLFANVRPCKSIQGYK--TPY 508 +++ L G + PI + + L LR+ FNLFAN+RP K K +P Sbjct: 64 GCEKSDAILFGSVGGKKWDNFPIEERPERAALLPLRKHFNLFANLRPAKIYSELKHLSPL 123 Query: 509 ------DNVDTVLIRENTEGEYSG-----------IEHVVVDGVVQSIKLITREASERVL 637 D D + IRE T G Y G IE+ + ++ R+ Sbjct: 124 RSNIVRDGFDILCIRELTGGIYFGQPSGRRLEKNNIEYAFDTEIYYDYEI------NRIA 177 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVV 817 AFQ AQ KV + K+ ++ S L+ + ++++K YP+++ +DNA ++++ Sbjct: 178 HLAFQLAQSRSH-KVCSIDKSNVLNSSI-LWKEIVQKVSKNYPDVDLSHLYIDNAIMQII 235 Query: 818 TDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAPDIAG 994 +P ++ VL+ PNL+GDI+SD CA + G +G+ PS ++ + + ++E GSAPDIAG Sbjct: 236 KNPNQFD--VLLCPNLFGDIISDECAIITGSIGMLPSASLNEKKFGLYEPAGGSAPDIAG 293 Query: 995 KGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKS---KTHEY 1162 K +ANP A +LS M++++ M L + A+KI ++ L +G T D+ + KT+E Sbjct: 294 KNIANPIAQILSLSMLVRYGMNLKDIADKIDKSVLSVLKKGYR-TADISNNNNYLKTNEM 352 Query: 1163 AAAVIKNL 1186 + L Sbjct: 353 GDVIANAL 360
>Q3AYS1:LEU3_SYNS9 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain CC9902)| Length = 357 Score = 129 bits (324), Expect = 3e-29 Identities = 113/347 (32%), Positives = 177/347 (51%), Gaps = 31/347 (8%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEI---AQSVKDIYSAAN--------VPIKWESIDVTPSLNADGKTV 334 +Y V L+ GDGIGPEI A+ + D+ + + PI +ID T Sbjct: 3 QYRVVLLPGDGIGPEITAVARQLLDVVAQRHGFQLMFEEQPIGGSAIDATGE-------P 55 Query: 335 IPDESIASIKRNYVALKGPLATPI------GKGHVSLNLTLRRTFNLFANVRPCKSIQGY 496 +P ++ + + L + +P K + L LR LFAN+RP K + Sbjct: 56 LPASTLTACRSADAVLLAAIGSPRFDSLPREKRPETGLLGLRSGLELFANLRPVKIVPAL 115 Query: 497 -------KTPYDNVDTVLIRENTEGEYSGIE--HVVVDGVVQSIKLITREASE--RVLRF 643 + + VD +++RE T G Y G + DG + +T ASE R+ + Sbjct: 116 IGASSLKQEVIEGVDLMVVRELTGGIYFGQPKGRIEADGDERGFNTMTYSASEVDRIAKV 175 Query: 644 AFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTD 823 AF+ A + ++ V KA ++ +S L+ + +A Y ++ +DNA +++V D Sbjct: 176 AFEIAGERNN-RLCSVDKANVLDVSQ-LWRDRVDAMAPRYGEVDVSHMYVDNAAMQLVRD 233 Query: 824 PTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKG 1000 P ++ VL+ NL+GDILSD A L G +G+ PS ++G D +FE VHGSAPDIAG+ Sbjct: 234 PRQFD--VLLTGNLFGDILSDEAAMLTGSIGMLPSASLGSDGPGLFEPVHGSAPDIAGQD 291 Query: 1001 LANPTALLLSSIMMLQHMGLFEH--ANKIQAAIFKTLAEGKTITGDL 1135 ANP A++LS+ MML+ +GL + A+ ++ A+ LA G TGDL Sbjct: 292 KANPMAMVLSAAMMLR-IGLKQSSAADDLERAVDAVLASGFR-TGDL 336
>Q9EVG3:LEU3_BUCML 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Macrosiphoniella ludovicianae Length = 365 Score = 129 bits (324), Expect = 3e-29 Identities = 106/343 (30%), Positives = 176/343 (51%), Gaps = 34/343 (9%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDI------YSAANVPIKWESIDVTPSLNADGKTVIPDES 349 +Y ++++ GDGIGPE+ + I Y + ++ IK +I +L+ +G +P ++ Sbjct: 4 QYRIAVLPGDGIGPEVMKEAYKILKILQNYFSLHIEIKEFNIGGI-ALDKEG-VALPKDT 61 Query: 350 IASIKRNYVALKGPLA------TPIGKGHVSLNLT-LRRTFNLFANVRPCK--------S 484 + + + L G + PI K +L LR+ FNLF N+RP K S Sbjct: 62 LLGCENSDAILFGSVGGKKWNNLPIEKRPERASLLPLRKHFNLFYNLRPAKLYSELRFLS 121 Query: 485 IQGYKTPYDN-VDTVLIRENTEGEYSG----------IEHVVVDGVVQSIKLITREASER 631 KT N D + IRE T G Y G IE+ V ++ R Sbjct: 122 PLRSKTXIKNGFDILCIRELTGGIYFGEPRGRLKKNNIEYAFDTEVYYDYEI------NR 175 Query: 632 VLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLK 811 + AFQ A+ K KV + KA ++ S L+ + +++K YP++ +DNA ++ Sbjct: 176 IAHVAFQLART-RKNKVCSIDKANVLN-SSLLWREIVTKVSKNYPDVHLSHLYIDNATMQ 233 Query: 812 VVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDI 988 ++ +P ++ +L+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDI Sbjct: 234 IIQNPNQFD--ILLCSNLFGDILSDECAIITGSIGMLPSASLNEKNFGLYEPAGGSAPDI 291 Query: 989 AGKGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 AGK +ANP A +LS M++++ M L + ANKI ++ L +G Sbjct: 292 AGKNIANPIAQILSLSMLVRYGMNLKKIANKIDQSVISVLKKG 334
>Q5LWZ5:LEU3_SILPO 3-isopropylmalate dehydrogenase - Silicibacter pomeroyi| Length = 367 Score = 129 bits (323), Expect = 4e-29 Identities = 112/363 (30%), Positives = 177/363 (48%), Gaps = 35/363 (9%) Frame = +2 Query: 203 LIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGK-----TVIPDESIASIKR 367 ++ GDGIGPE+ V+ I + + DV+ L + DE++A + Sbjct: 8 ILPGDGIGPEVMAEVRKIIGWFGDK-RGLNFDVSEDLVGGAAYDVHGVPLADETMAKAQE 66 Query: 368 NYVALKGPLATP-------IGKGHVSLNLTLRRTFNLFANVRPCKSIQGY-------KTP 505 L G + P K L L LR+ +LF+N+RP + K Sbjct: 67 ADAVLLGAVGGPKYDDLDFSVKPERGL-LRLRKEMDLFSNLRPAQCFDALADFSSLKKDI 125 Query: 506 YDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASE----RVLRFAFQYAQDIGK 673 +D +++RE T G Y G + + + + + T+ +E RV R AF+ A K Sbjct: 126 VAGLDIMIVRELTSGVYFGEPRGIFEEGNERVGINTQRYTESEIERVARSAFELAMRRSK 185 Query: 674 PKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLV 853 K+ + KA +M+ S L+ + +AK+YP +E DN +++V P ++ V++ Sbjct: 186 -KLCSMEKANVME-SGILWREVVTRVAKDYPEVELSHMYADNGAMQLVRAPKQFD--VIL 241 Query: 854 MPNLYGDILSDMCAGLIGGLGLTPSGNIGDECS------IFEAVHGSAPDIAGKGLANPT 1015 NL+GDILSD A L G LG+ PS ++G + ++E VHGSAPDIAG+G ANP Sbjct: 242 TDNLFGDILSDCAAMLTGSLGMLPSASLGAPMANGRPKALYEPVHGSAPDIAGQGKANPI 301 Query: 1016 ALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKS-----KTHEYAAAVI 1177 A +LS M L++ A++++AA+ + LA+G T DL G T E AA++ Sbjct: 302 ACILSFAMALRYSFDQGAEADRLEAAVEQVLADG-VRTADLLGTEGVTPVSTTEMGAAIL 360 Query: 1178 KNL 1186 L Sbjct: 361 AKL 363
>Q9EVG9:LEU3_BUCUM 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Uroleucon ambrosiae Length = 365 Score = 129 bits (323), Expect = 4e-29 Identities = 106/372 (28%), Positives = 181/372 (48%), Gaps = 39/372 (10%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKR 367 KY +S++ GDGIGPE+ +++ Y N+ S+ + G I E +A K+ Sbjct: 4 KYRISVLPGDGIGPEV---MREAYKILNILKNHFSLPLEIKEFNIGGAAIDQEGVALPKK 60 Query: 368 NYVALKGPLATPIGK------GHVSLN--------LTLRRTFNLFANVRPCK--SIQGYK 499 + + A G H+ ++ L LR+ FNLFAN+RP + S Y Sbjct: 61 TLLGCENSDAILFGSVGGKKWDHLPIDKRPERASLLPLRKHFNLFANLRPAQLYSELKYL 120 Query: 500 TPY-------DNVDTVLIRENTEGEYSG-----------IEHVVVDGVVQSIKLITREAS 625 +P + + + IRE T G Y G IE+ + ++ Sbjct: 121 SPLRSDIXIKNGFNILCIRELTGGIYFGKPTGRXLKKNNIEYAFDTEIYYDYEI------ 174 Query: 626 ERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNAC 805 R+ AFQ AQ KV + K+ ++ S L+ ++++K YP++ +DNA Sbjct: 175 NRIAHLAFQLAQTRNY-KVCSIDKSNVLN-SSVLWRETVQKVSKNYPDVHLSHLYIDNAT 232 Query: 806 LKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAP 982 ++++ DP ++ +L+ NL+GDI+SD CA + G +G+ PS ++ + + ++E GSAP Sbjct: 233 MQIIKDPNQFD--ILLCSNLFGDIVSDECAIITGSIGMLPSASLNEKKFGLYEPAGGSAP 290 Query: 983 DIAGKGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKS---K 1150 DI GK +ANP A +LS M++++ M L + A+KI ++ L +G T D+ + K Sbjct: 291 DIEGKNIANPIAQILSVSMLVRYGMNLKKIADKIDQSVISVLKKGYR-TADISNNNNYLK 349 Query: 1151 THEYAAAVIKNL 1186 T+E + L Sbjct: 350 TNEMGDVIANTL 361
>Q748X2:LEU3_GEOSL 3-isopropylmalate dehydrogenase - Geobacter sulfurreducens| Length = 362 Score = 128 bits (322), Expect = 5e-29 Identities = 108/334 (32%), Positives = 169/334 (50%), Gaps = 26/334 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSA--ANVPIKWESIDVT---PSLNADGKTVIPDESIA 355 + V+++ GDGIGPE+ + A A +K+E ++ +GK +P+ ++ Sbjct: 5 FKVAVLPGDGIGPEVMAEALRVLDAVEAKYDVKFERTHANVGGAGIDIEGKA-LPETTVN 63 Query: 356 SIKRNYVALKGPLATPIGKG-------HVSLNLTLRRTFNLFANVRPC---KSIQGYKTP 505 K L G + P + L LR+ F L+AN+RP S+ G + Sbjct: 64 ICKAADAILFGSVGGPKWESLPPDEQPERGALLPLRKIFGLYANLRPAIIFPSLTGASSL 123 Query: 506 YDNV-----DTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFAFQYA 658 + V + ++IRE T G Y GIE D V + ER+ AFQ A Sbjct: 124 KEEVIAGGFNVLVIRELTGGIYFAQPKGIEGEGRDRVGFDTMRYSVPEIERITHVAFQAA 183 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 + GK KV + KA ++ S L+ + IAKEYP++E +DNA +++V P ++ Sbjct: 184 RKRGK-KVCSIDKANVLS-SSVLWREVVTGIAKEYPDVELSHMYVDNAAMQLVRWPKQFD 241 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPT 1015 V++ N++GDILSD A L G LG+ PS ++ + ++E GSAPDIAG+G+ANP Sbjct: 242 --VILCENMFGDILSDEAAMLTGSLGMLPSASLAEGTFGMYEPSGGSAPDIAGQGIANPI 299 Query: 1016 ALLLSSIMMLQ-HMGLFEHANKIQAAIFKTLAEG 1114 A +LS MML+ G+ + A+ I A+ L +G Sbjct: 300 AQILSMGMMLKFSFGMVDAADAIDNAVATVLDQG 333
>Q21CS1:LEU3_RHOPB 3-isopropylmalate dehydrogenase - Rhodopseudomonas palustris (strain| BisB18) Length = 370 Score = 128 bits (321), Expect = 6e-29 Identities = 114/350 (32%), Positives = 176/350 (50%), Gaps = 33/350 (9%) Frame = +2 Query: 203 LIEGDGIGPEIAQSVKDIYSAANVP--IKWESIDVT---PSLNADGKTVIPDESIASIKR 367 L+ GDGIG E+ VK + N +E+ D + +AD K I D ++A + Sbjct: 8 LLPGDGIGTEVMAEVKRLIDWLNAQGIAHFETEDGLVGGAAYDAD-KVAITDATMAKAQA 66 Query: 368 NYVALKGPLA------TPIGKGHVSLNLTLRRTFNLFANVRPC-------KSIQGYKTPY 508 + + G + P + L LR+ LFAN+RP S + Sbjct: 67 SDAVIFGAVGGAKWDGVPYEARPEAGLLRLRKDLGLFANLRPAVCYPALADSSSLKREVV 126 Query: 509 DNVDTVLIRENTEGEYSGIEHVVVD---GVVQSIKLITREASE--RVLRFAFQYAQDIGK 673 + +D +++RE T G Y G + D G ++I ++ E R+ R AF A+ + Sbjct: 127 EGLDIMIVRELTGGVYFGEPKTITDLGNGQKRAIDTQVYDSYEIDRIARVAFDLARK-RR 185 Query: 674 PKVRVVHKATIMKMSDGLFLN--LGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKV 847 KV + K +MK G+ N + R A++Y +++ + +L D+ + +V P ++ V Sbjct: 186 NKVTSMEKRNVMK--SGVLWNEVVTRVHAEDYKDVQLEHQLADSGGMNLVKWPKQFD--V 241 Query: 848 LVMPNLYGDILSDMCAGLIGGLGLTPSG-------NIGDECSIFEAVHGSAPDIAGKGLA 1006 +V NL+GDILSD+ A L G LG+ PS N G S++E VHGSAPDIAGKGLA Sbjct: 242 IVTDNLFGDILSDIAAMLTGSLGMLPSASLGAVDANTGKRKSMYEPVHGSAPDIAGKGLA 301 Query: 1007 NPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 NP A+L S M L++ + + E A+K+ AAI LA+G T D+ + T Sbjct: 302 NPVAMLASFGMALRYSLDMGELADKLDAAIAAVLAKGLR-TADIKSEGST 350
>P87257:LEU3B_ASPNG 3-isopropylmalate dehydrogenase B - Aspergillus niger| Length = 371 Score = 127 bits (320), Expect = 8e-29 Identities = 109/364 (29%), Positives = 180/364 (49%), Gaps = 32/364 (8%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVKDIYSAANVPIKW---ESIDVTPSLNADGKTV---IPDES 349 Y + ++ GDGIGPE+ A+++K + + + +++ E + S++ G +V + D + Sbjct: 7 YNILVLPGDGIGPEVMAEAIKVLRTFNSSSMQFHLQEELIGGISIDTHGHSVTQPVKDAA 66 Query: 350 IASIKRNYVALKGPLATPIGKGHVSLN---LTLRRTFNLFANVRPC------KSIQGYKT 502 +A+ + A+ G I +G L +R+ +++AN+RPC + I + Sbjct: 67 VAADAVLFAAVGGSKVDHIRRGLDGPEGGLLQVRKAMDIYANLRPCSVDVPSREIARDFS 126 Query: 503 PY-----DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDI 667 P+ + VD V++REN G Y G + + + T E +R+ R A + A Sbjct: 127 PFRQEVIEGVDFVVVRENCGGAYFGKKVEEENYAMDEWGYSTTEI-QRIARLAAELALRH 185 Query: 668 GKP-KVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 P V + KA ++ S + I+ EYP ++ +L D+A L + TDP N Sbjct: 186 DPPWPVISLDKANVLASSRLWRRVVENTISVEYPQVKLVHQLADSASLIMATDPRVLNG- 244 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD---------ECSIFEAVHGSAPDIAGK 997 V++ N +GD+LSD LIG LG+ PS ++ ++E HGSAP IAGK Sbjct: 245 VILADNTFGDMLSDQAGSLIGTLGVLPSASLDGLPHPGKQEKVRGLYEPTHGSAPTIAGK 304 Query: 998 GLANPTALLLS-SIMMLQHMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAV 1174 +ANPTA++L S+M + A +I+ A+ L G T DLGG S T E+ AV Sbjct: 305 NIANPTAMILCVSLMFRYSFNMENEARQIEDAVRAVLDRGLR-TPDLGGNSSTQEFGDAV 363 Query: 1175 IKNL 1186 + L Sbjct: 364 VAAL 367
>P59029:LEU3_SYNEL 3-isopropylmalate dehydrogenase - Synechococcus elongatus| (Thermosynechococcus elongatus) Length = 361 Score = 127 bits (318), Expect = 1e-28 Identities = 115/345 (33%), Positives = 179/345 (51%), Gaps = 30/345 (8%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSL------NADGKTVIPDESI 352 Y ++++ GDGIGPEI D+ A P D P+L +A G+ +P ++ Sbjct: 5 YRIAVLAGDGIGPEITAVALDVLRAI-APRFGLDFDFVPALVGGCAIDAVGEP-LPAATL 62 Query: 353 ASIKRNYVALKGPLATPIGKGHVSLN---------LTLRRTFNLFANVRPCKSIQGYKTP 505 A+ +++ L LA G SL L LR LFAN+RP K Sbjct: 63 ATCRQSDAVL---LAAIGGTQWDSLPRHLRPETGLLALRSGLGLFANLRPAKIFPQLLHA 119 Query: 506 YD-------NVDTVLIRENTEGEYSGIEHVVVD---GVVQSIKLITREASE--RVLRFAF 649 VD +++RE T G Y G + G + + + A+E R+ R AF Sbjct: 120 SSLKPEVIAGVDLMVVRELTGGIYFGQPRGIFTTETGEQRGVNTMAYTATEIDRIGRVAF 179 Query: 650 QYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPT 829 + A+ + K+ V KA ++++S L+ + ++ EYP++E +DNA +++V P Sbjct: 180 ETARK-RQGKLCSVDKANVLEVSQ-LWRDRLTALSAEYPDVELTHLYVDNAAMQLVRAPK 237 Query: 830 PYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLA 1006 ++ +V NL+GDILSD+ A L G +G+ PS ++G+ ++FE VHGSAPDIAG+ A Sbjct: 238 QFD--TIVTSNLFGDILSDIAAMLTGSIGMLPSASLGESGPALFEPVHGSAPDIAGQDKA 295 Query: 1007 NPTALLLSSIMMLQHMGLFE--HANKIQAAIFKTLAEGKTITGDL 1135 NP A++LS+ MML++ GL + A I+ AI L +G TGDL Sbjct: 296 NPLAMVLSAAMMLRY-GLNQPAAAQAIEEAITAVLDQGYR-TGDL 338
>Q8E9N3:LEU3_SHEON 3-isopropylmalate dehydrogenase - Shewanella oneidensis| Length = 364 Score = 127 bits (318), Expect = 1e-28 Identities = 107/354 (30%), Positives = 175/354 (49%), Gaps = 26/354 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++++ GDGIGPE+ + + A + I++ DV + +P+ ++ Sbjct: 3 YQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKG 62 Query: 359 IKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQG--YKTPYD 511 + L G + P + L LR F LF N+RP K G + +P Sbjct: 63 CEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLR 122 Query: 512 N------VDTVLIRENTEGEYSGIE-----HVVVDGVVQSIKLITREASERVLRFAFQYA 658 + D + +RE T G Y G + +++ RE S R+ R AF+ A Sbjct: 123 SDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREIS-RIARIAFEAA 181 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 + K KV V KA ++ S L+ + E+A ++P++E + +DNA ++++ P ++ Sbjct: 182 RGRRK-KVTSVDKANVLACSV-LWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFD 239 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPT 1015 V++ NL+GDILSD A L G +GL S ++ +FE GSAPDIAGKG+ANP Sbjct: 240 --VMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPI 297 Query: 1016 ALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAAV 1174 A +LS+ +ML+H + E A+ I+ A+ K L G +TG+L + H+ V Sbjct: 298 AQILSAALMLRHSLKQEEAASAIERAVTKALNSG-YLTGELLSSDQRHKAKTTV 350
>Q1LKH7:LEU3_RALME 3-isopropylmalate dehydrogenase - Ralstonia metallidurans (strain| CH34 / ATCC 43123 / DSM 2839) Length = 355 Score = 127 bits (318), Expect = 1e-28 Identities = 106/333 (31%), Positives = 171/333 (51%), Gaps = 27/333 (8%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPS-LNADGKTVIPDESIASIKRNY 373 ++++ GDGIGPEI + +A + + E+ V + A+G +PD ++ K Sbjct: 3 IAVLPGDGIGPEIVAEAVKVLNALDEKFEMETAPVGGAGYEAEGHP-LPDNTLKLAKEAD 61 Query: 374 VALKGP--------LATPIGKGHVSLNLTLRRTFNLFANVRPC---KSIQGYKTPYDNV- 517 L G L P+ L L R+ LFAN RP + G + + Sbjct: 62 AILFGAVGDWKYDSLDRPLRPEQAILGL--RKHLQLFANFRPAICYPELTGASSLKPELV 119 Query: 518 ---DTVLIRENTEGEYSGIEHVV---VDGVVQSIK--LITREASE----RVLRFAFQYAQ 661 D +++RE Y G V DG+ + + T SE R+ AFQ A Sbjct: 120 AGLDILIVRELNGDIYFGQPRGVREAPDGLFKGAREGFDTMRYSEPEVRRIAHVAFQAAA 179 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 GK K+ V KA +++ + ++ +++KEYP++E +DNA +++V P ++ Sbjct: 180 KRGK-KLCSVDKANVLETFQ-FWKDIVIDVSKEYPDVELSHMYVDNAAMQLVKAPKSFD- 236 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNI-GDECSIFEAVHGSAPDIAGKGLANPTA 1018 V+V N++GDILSD A L G +G+ PS ++ + ++E HGSAPDIAGKG+ANP A Sbjct: 237 -VIVTGNMFGDILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGVANPLA 295 Query: 1019 LLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 +LS+ MML++ + E A++I+ A+ K LA+G Sbjct: 296 TILSAAMMLRYSLNRAEQADRIENAVKKVLAQG 328
>P31958:LEU3_CLOPA 3-isopropylmalate dehydrogenase - Clostridium pasteurianum| Length = 357 Score = 127 bits (318), Expect = 1e-28 Identities = 104/333 (31%), Positives = 170/333 (51%), Gaps = 24/333 (7%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAAN--VPIKWESIDVTP---SLNADGKTVIPDESI 352 ++ +++I GDGIGP+I + I + K+ ++V +++A G+ +P E+I Sbjct: 3 EFKIAVIPGDGIGPDIVREAVKIMTKVGEKYDTKFNFVEVKAGGDAIDAYGEP-LPKETI 61 Query: 353 ASIKRNYVALKGPLATPI------GKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT--PY 508 K + L G + P K L LR L+AN+RP K K+ P Sbjct: 62 DVCKSSAAVLLGAVGGPKWDNLEGSKRPERALLGLRGALGLYANLRPAKVYNVLKSASPL 121 Query: 509 DN------VDTVLIRENTEGEYSGIEHVV-VDGVVQSIKLITREASE--RVLRFAFQYAQ 661 N VD +++RE G Y G V+GV + E R+ AF+ A Sbjct: 122 KNEIIDEGVDLLVVRELIGGIYFGDRGTKEVNGVETAFDTEKYNVDEVKRIAHSAFKAAM 181 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 K KV V KA ++ S L+ E++KEYP +E +DN +++V P+ ++ Sbjct: 182 KRRK-KVTSVDKANVLDASR-LWRKTVNEVSKEYPEVELSHLYVDNTAMQLVRKPSQFD- 238 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTA 1018 V++ N++GDILSD + + G +G+ S +I D ++E +HGSAPDIAG +ANP A Sbjct: 239 -VILTNNIFGDILSDEASMITGSIGMLASSSIREDSFGMYEPIHGSAPDIAGLDIANPLA 297 Query: 1019 LLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 +LS+ M++++ + + E A ++AA+ K L EG Sbjct: 298 QILSAAMLMEYSLDMSEAARDVEAAVEKVLNEG 330
>Q9EVH8:LEU3_BUCUH 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Uroleucon helianthicola Length = 363 Score = 127 bits (318), Expect = 1e-28 Identities = 102/343 (29%), Positives = 171/343 (49%), Gaps = 34/343 (9%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKR 367 KY ++++ GDGIGPE+ +++ Y ++ S+ + G + I E IA K+ Sbjct: 4 KYRIAILPGDGIGPEV---MREAYKILSILKDHFSLSLEIQEFNIGGSAIDQEGIALPKK 60 Query: 368 NYVALKGPLATPIGK------GHVSLN--------LTLRRTFNLFANVRPCK---SIQGY 496 + + A G H+ +N L LR+ FNLFAN+RP K +Q Sbjct: 61 TLLGCQNSDAILFGSVGGKRWDHLPINERPERASLLPLRKHFNLFANLRPAKLYSELQHL 120 Query: 497 KTPYDNV-----DTVLIRENTEGEYSG----------IEHVVVDGVVQSIKLITREASER 631 N+ D + +RE T G Y G +E+ V ++ R Sbjct: 121 SPIRSNIIKNGFDILCVRELTGGIYFGKPSDRVKKNNVEYAFDTEVYYDYEI------NR 174 Query: 632 VLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLK 811 + AFQ A+ K KV + K+ ++ S L+ + +++K YP++ +DNA ++ Sbjct: 175 IAHLAFQLART-RKFKVCSIDKSNVLNSSI-LWREVVEKVSKMYPDVHLSHLYIDNATMQ 232 Query: 812 VVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDI 988 ++ +P ++ VL+ NL+GDI+SD CA + G +G+ PS + ++ ++E GSAPDI Sbjct: 233 IIKNPNQFD--VLLCSNLFGDIISDECAVITGSIGMLPSASFNEKNFGLYEPAGGSAPDI 290 Query: 989 AGKGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 AGK ANP A +LS M++++ M L + A+KI A+ +L G Sbjct: 291 AGKNTANPIAQILSLSMLVRYGMKLNKIADKIDDAVALSLKAG 333
>Q7V842:LEU3_PROMM 3-isopropylmalate dehydrogenase - Prochlorococcus marinus (strain MIT| 9313) Length = 357 Score = 126 bits (317), Expect = 2e-28 Identities = 108/341 (31%), Positives = 179/341 (52%), Gaps = 25/341 (7%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDV-TPSLNADGKTVIPDESI 352 ++ + L+ GDGIGPEI K + A + +E + +++A G + +P ++ Sbjct: 3 QHRIVLLPGDGIGPEITAVAKLLLDALGHQHGFKLNFEQHPIGGVAIDASG-SPLPASTL 61 Query: 353 ASIKRNYVALKGPL------ATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY------ 496 + + + L + A P + + L+LR LFAN+RP + Sbjct: 62 EACQASDAVLLAAIGSPRFDALPREQRPETGLLSLRAGLKLFANLRPVTILPALIDASSL 121 Query: 497 -KTPYDNVDTVLIRENTEGEYSGIE--HVVVDGVVQSIKLIT--REASERVLRFAFQYAQ 661 VD +++RE T G Y G + DG ++ +T R +R+ + AF+ A+ Sbjct: 122 KANVIKGVDLMVVRELTGGIYFGQPKGRIEADGDERAFNTMTYSRTEVDRIAKVAFELAR 181 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 D K+ V KA ++ +S L+ + +A Y ++E +DNA +++V +P ++ Sbjct: 182 D-RSGKLCSVDKANVLDVSQ-LWRDRVDALAANYGDVELSHMYVDNAAMQLVRNPRQFD- 238 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPTA 1018 VL+ NL+GDILSD A L G +G+ PS ++G E +FE VHGSAPDIAG+ LANP A Sbjct: 239 -VLLTGNLFGDILSDEAAMLTGSIGMLPSASLGSEGPGLFEPVHGSAPDIAGQDLANPMA 297 Query: 1019 LLLSSIMMLQHMGLFEH--ANKIQAAIFKTLAEGKTITGDL 1135 ++L + MML+ +GL E+ A ++ ++ + LA G TGDL Sbjct: 298 MVLCAAMMLR-IGLKENDAARALEGSVERVLAAGFR-TGDL 336
>Q9Y897:LEU3_MYCGR 3-isopropylmalate dehydrogenase - Mycosphaerella graminicola| (Septoria tritici) Length = 365 Score = 126 bits (317), Expect = 2e-28 Identities = 115/365 (31%), Positives = 180/365 (49%), Gaps = 33/365 (9%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI---AQSVKDIYSAANVPIKWESIDVTP------SLNADGKTVIPD 343 Y + + GD GPE+ A V D+ +N + + ++ P S++A G+ + D Sbjct: 4 YNIVVFGGDHCGPEVTAEALKVLDVIDNSNADVHF---NIQPHLLGGASIDAHGEP-LTD 59 Query: 344 ESIASIKRNYVALKGPLATPI-GKGHVSLN---LTLRRTFNLFANVRPC--------KSI 487 E++A+ K + G + P G G V L LR+ + N+RPC K+ Sbjct: 60 EALAAAKAADAVILGAIGGPKWGTGKVRPEQGILRLRKEMGTYGNLRPCFFASESLVKTS 119 Query: 488 QGYKTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKL--ITREASERVLRFA--FQY 655 + V+ ++RE T G Y G E DG ++ +R ERV R A Sbjct: 120 PLKEEVCRGVNFNIVRELTGGIYFG-ERTEDDGSGYAVDTEPYSRAEIERVARLAGFLAL 178 Query: 656 AQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPY 835 A+D P V + KA +M S + A E+P ++ L+D+A + +V +P Sbjct: 179 AEDPPCP-VWSLDKANVMATSRLWRKTVTDVFANEFPQLKIGHHLIDSAAMLMVKNPRAL 237 Query: 836 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIG------DECS-IFEAVHGSAPDIAG 994 N V+V NL+GDI+SD + + G LGL PS ++ +C+ I+E +HGSAPDI+G Sbjct: 238 NG-VIVTSNLFGDIISDEASVIPGSLGLLPSASLTASPDGKSKCNGIYEPIHGSAPDISG 296 Query: 995 KGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTHEYAAA 1171 KG+ NP A++LS MM ++ + E A KI A+ + +G T D+GG +KT E A Sbjct: 297 KGIVNPVAMILSLGMMCKYSLQQPELAKKIDEAVRNVIEKGIN-TADIGGSAKTAEVGDA 355 Query: 1172 VIKNL 1186 + K L Sbjct: 356 IAKEL 360
>Q4QLS3:LEU3_HAEI8 3-isopropylmalate dehydrogenase - Haemophilus influenzae (strain| 86-028NP) Length = 358 Score = 126 bits (317), Expect = 2e-28 Identities = 107/345 (31%), Positives = 169/345 (48%), Gaps = 26/345 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEI-AQSVK---DIYSAANVPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y V+++ GDGIGPE+ A+++K + + + V + +P E++ Sbjct: 4 YNVAVLAGDGIGPEVMAEAMKVLNKVQEKFGFKLNFNEFFVGGAAIDHCGYPLPAETLKG 63 Query: 359 IKRNYVALKGPLA-------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKT----- 502 L G + P + L LR+ F LF N+RP +G + Sbjct: 64 CDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFCPLR 123 Query: 503 ---PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQYA 658 D V++RE T G Y G + +G K E ER+ R AF+ A Sbjct: 124 ADIAAKGFDMVVVRELTGGIYFG-QPKGREGEGSQTKAFDTEVYYKYEIERIARAAFEAA 182 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 K KV V KA +++ S L+ E+AK+YP + + +DNA ++++ P ++ Sbjct: 183 MKRNK-KVTSVDKANVLQSSI-LWRETVTEMAKDYPEVTLEHIYIDNATMQLIKAPESFD 240 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLANPT 1015 VL+ N++GDI+SD A + G +G+ PS ++ + ++E GSAPDIAGKG+ANP Sbjct: 241 --VLLCSNIFGDIISDEAAMITGSMGMLPSASLNEAGFGLYEPAGGSAPDIAGKGIANPI 298 Query: 1016 ALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKS 1147 A +LS+ MML++ L E A+ I++A+ K LA G T DL S Sbjct: 299 AQILSAAMMLRYSFNLNEAADAIESAVQKVLASGHR-TADLADDS 342
>Q9EVI7:LEU3_BUCUN 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Uroleucon sonchi Length = 364 Score = 126 bits (317), Expect = 2e-28 Identities = 99/341 (29%), Positives = 171/341 (50%), Gaps = 32/341 (9%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIA 355 KY ++++ GDGIGPE+ + I + ++P++ E DV S +P +++ Sbjct: 4 KYRIAVLPGDGIGPEVMREAYKILNILKYHFSLPLEIEEFDVGGSAIDKEGVALPKKTLL 63 Query: 356 SIKRNYVALKGPL------ATPIGKGHVSLNLT-LRRTFNLFANVRPCK--SIQGYKTPY 508 + L G + + PI + +L LR+ FNLFAN+RP + S Y +P Sbjct: 64 GCENADAILFGSVGGRKWDSLPIDQRPERASLLPLRKHFNLFANLRPAQLYSELKYLSPL 123 Query: 509 -------DNVDTVLIRENTEGEYSG----------IEHVVVDGVVQSIKLITREASERVL 637 + + + +RE T G Y G E+ V ++ R+ Sbjct: 124 AFLIVIKNGFNILCVRELTGGIYFGQPSGRSKTNNFEYAFDTEVYYDYEI------NRIA 177 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVV 817 AFQ AQ KV + K+ ++ S L+ + ++++ YPN+ +DNA ++++ Sbjct: 178 HLAFQLAQTRNY-KVCSIDKSNVLNSSI-LWREIVKKVSLSYPNVHLSHLYIDNATMQII 235 Query: 818 TDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAPDIAG 994 DP ++ VL+ NL+GDI+SD CA + G +G+ PS ++ + + ++E GSAPDI G Sbjct: 236 KDPNQFD--VLLCSNLFGDIISDECAIITGSIGMLPSASLNEKKFGLYEPAGGSAPDIEG 293 Query: 995 KGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 K +ANP A +LS M++++ M L A+KI ++ L +G Sbjct: 294 KNIANPIAQILSVSMLVRYSMNLKNIADKIDYSVISILKKG 334
>Q3M8T9:LEU3_ANAVT 3-isopropylmalate dehydrogenase - Anabaena variabilis (strain ATCC| 29413 / PCC 7937) Length = 362 Score = 126 bits (317), Expect = 2e-28 Identities = 103/340 (30%), Positives = 176/340 (51%), Gaps = 25/340 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIK-----WESIDVTPSLNADGKTVIPDESIA 355 Y ++L+ GDGIGPEI D+ E++ +++A G+ +P ++ Sbjct: 5 YRITLLPGDGIGPEIMAVAVDVLKVVGQQFDIQFDFQEALIGGAAIDATGEP-LPSATLD 63 Query: 356 SIKRNYVALKGPL------ATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY------- 496 + +++ L + + P + L LR LFAN+RP + + Sbjct: 64 TCRQSDAVLLAAIGGYKWDSLPPHQRPEGGLLGLRAGLELFANLRPAQILPQLIDASTLK 123 Query: 497 KTPYDNVDTVLIRENTEGEYSGIEHVVVD---GVVQSIKLITREASE--RVLRFAFQYAQ 661 + + VD +++RE T G Y G + G + + + SE R+ R AF+ A+ Sbjct: 124 REVVEGVDIMVVRELTGGIYFGKPRGIFTTETGEKRGVNTMVYTESEIDRIGRIAFETAR 183 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 + K+ V KA ++ +S L+ + ++++EYP++E +DNA +++V P ++ Sbjct: 184 K-RRGKLCSVDKANVLDVSQ-LWRDRITKLSQEYPDVELSHLYVDNAAMQLVRAPKQFD- 240 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTA 1018 +V NL+GDILSD A L G +G+ PS ++G +FE VHGSAPDIAG ANP A Sbjct: 241 -TIVTGNLFGDILSDAAAMLTGSIGMLPSASLGASGPGVFEPVHGSAPDIAGLDKANPLA 299 Query: 1019 LLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 +LS+ MML++ + + A+KI+ A+ + L +G TGD+ Sbjct: 300 QVLSAAMMLRYALNQPQAADKIEQAVLQVLEQGDR-TGDI 338
>Q8YXA2:LEU3_ANASP 3-isopropylmalate dehydrogenase - Anabaena sp. (strain PCC 7120)| Length = 362 Score = 126 bits (317), Expect = 2e-28 Identities = 103/340 (30%), Positives = 175/340 (51%), Gaps = 25/340 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIK-----WESIDVTPSLNADGKTVIPDESIA 355 Y ++L+ GDGIGPEI D+ E++ +++A G+ +P ++ Sbjct: 5 YRITLLPGDGIGPEIMAVAVDVLKVVGQQFDIQFDFQEALIGGAAIDATGEP-LPSATLD 63 Query: 356 SIKRNYVALKGPL------ATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY------- 496 + + + L + + P + L LR LFAN+RP + + Sbjct: 64 TCRHSDAVLLAAIGGYKWDSLPPHQRPEGGLLGLRAGLELFANLRPAQILPQLIDASTLK 123 Query: 497 KTPYDNVDTVLIRENTEGEYSGIEHVVVD---GVVQSIKLITREASE--RVLRFAFQYAQ 661 + + VD +++RE T G Y G + G + + + SE R+ R AF+ A+ Sbjct: 124 REVVEGVDIMVVRELTGGIYFGKPRGIFTTETGEKRGVNTMVYTESEIDRIGRIAFETAR 183 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 + K+ V KA ++ +S L+ + +++EYP++E +DNA +++V P ++ Sbjct: 184 K-RRGKLCSVDKANVLDVSQ-LWRDRITNLSQEYPDVELSHLYVDNAAMQLVRAPKQFD- 240 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTA 1018 +V NL+GDILSD A L G +G+ PS ++G +FE VHGSAPDIAG+ ANP A Sbjct: 241 -TIVTGNLFGDILSDAAAMLTGSIGMLPSASLGASGPGVFEPVHGSAPDIAGQDKANPLA 299 Query: 1019 LLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 +LS+ MML++ + + A+KI+ A+ + L +G TGD+ Sbjct: 300 QVLSAAMMLRYALDQPQAADKIEQAVLQVLEQGDR-TGDI 338
>Q31N34:LEU3_SYNP7 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain PCC 7942)| (Anacystis nidulans R2) Length = 365 Score = 126 bits (316), Expect = 2e-28 Identities = 109/346 (31%), Positives = 181/346 (52%), Gaps = 25/346 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPS-LNADGKTVIPDESIA 355 Y ++L+ GDGIGPEI DI A ++ ++E + S ++A G+ +P+ ++A Sbjct: 5 YRITLLPGDGIGPEIMAVTVDILRAIGRQFDLNFEFEEALIGGSAIDATGEP-LPEATLA 63 Query: 356 SIKRNYVALKGPL------ATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY------- 496 + + + L + + P + + L LR LFAN+RP + Sbjct: 64 TCRNSDAVLLAAIGGYKWDSLPRSQRPETGLLGLRAGLGLFANLRPAAILPQLVDASSLK 123 Query: 497 KTPYDNVDTVLIRENTEGEYSGIEHVVV---DGVVQSIKLITREASE--RVLRFAFQYAQ 661 + + VD +++RE T G Y G G ++ + E R+ R AF A+ Sbjct: 124 REVIEGVDLMVVRELTGGIYFGEPKGCFADEQGRQRAFNTMVYREDEIDRIGRVAFDIAR 183 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 GK ++ V KA ++++S L+ + + +Y ++E +DNA +++V P ++ Sbjct: 184 KRGK-RLCSVDKANVLEVSQ-LWRDRMTLLGSDYADVELSHLYVDNAAMQLVRWPKQFD- 240 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTA 1018 +V NL+GDILSD+ A L G +G+ PS ++G E +FE VHGSAPDIAG+ ANP A Sbjct: 241 -TIVTGNLFGDILSDIAAMLTGSIGMLPSASLGAEGPGVFEPVHGSAPDIAGQDKANPLA 299 Query: 1019 LLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 +LS+ MML++ + E A +I+AA+ + L +G TGDL + T Sbjct: 300 QVLSAAMMLRYGLDEPEAAARIEAAVNQVLDQGYR-TGDLYSEGMT 344
>Q5MZ40:LEU3_SYNP6 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain ATCC| 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) Length = 365 Score = 126 bits (316), Expect = 2e-28 Identities = 109/346 (31%), Positives = 181/346 (52%), Gaps = 25/346 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPS-LNADGKTVIPDESIA 355 Y ++L+ GDGIGPEI DI A ++ ++E + S ++A G+ +P+ ++A Sbjct: 5 YRITLLPGDGIGPEIMAVTVDILRAIGRQFDLNFEFEEALIGGSAIDATGEP-LPEATLA 63 Query: 356 SIKRNYVALKGPL------ATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY------- 496 + + + L + + P + + L LR LFAN+RP + Sbjct: 64 TCRNSDAVLLAAIGGYKWDSLPRSQRPETGLLGLRAGLGLFANLRPAAILPQLVDASSLK 123 Query: 497 KTPYDNVDTVLIRENTEGEYSGIEHVVV---DGVVQSIKLITREASE--RVLRFAFQYAQ 661 + + VD +++RE T G Y G G ++ + E R+ R AF A+ Sbjct: 124 REVIEGVDLMVVRELTGGIYFGEPKGCFADEQGRQRAFNTMVYREDEIDRIGRVAFDIAR 183 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 GK ++ V KA ++++S L+ + + +Y ++E +DNA +++V P ++ Sbjct: 184 KRGK-RLCSVDKANVLEVSQ-LWRDRMTLLGSDYADVELSHLYVDNAAMQLVRWPKQFD- 240 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTA 1018 +V NL+GDILSD+ A L G +G+ PS ++G E +FE VHGSAPDIAG+ ANP A Sbjct: 241 -TIVTGNLFGDILSDIAAMLTGSIGMLPSASLGAEGPGVFEPVHGSAPDIAGQDKANPLA 299 Query: 1019 LLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKT 1153 +LS+ MML++ + E A +I+AA+ + L +G TGDL + T Sbjct: 300 QVLSAAMMLRYGLDEPEAAARIEAAVNQVLDQGYR-TGDLYSEGMT 344
>Q3A3B2:LEU3_PELCD 3-isopropylmalate dehydrogenase - Pelobacter carbinolicus (strain DSM| 2380 / Gra Bd 1) Length = 365 Score = 126 bits (316), Expect = 2e-28 Identities = 105/342 (30%), Positives = 171/342 (50%), Gaps = 26/342 (7%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAAN----VPIKWESIDVT-PSLNADGKTVIPDESI 352 ++ ++++ GDGIGPEI + A V + + +V +++ DGK +PD ++ Sbjct: 4 EFKLAVLPGDGIGPEIMAEAMKVLDAVEQKFQVRFERQFANVGGAAIDRDGKA-LPDATV 62 Query: 353 ASIKRNYVALKGPLATPIG-------KGHVSLNLTLRRTFNLFANVRPC------KSIQG 493 + + L G + P + L LRR F LF N+RP S Sbjct: 63 EICQASDAILFGSVGGPKWDTLPAEERPERGALLPLRRIFGLFCNLRPAIVFPALTSASS 122 Query: 494 YKTPY--DNVDTVLIRENTEGEY----SGIEHVVVDGVVQSIKLITREASERVLRFAFQY 655 K D +++RE T G Y G+E + T ER+ R AF Sbjct: 123 LKEEVIAGGFDILVVRELTGGIYFAQPKGVEGEGGERRGFDTMAYTDAEVERITRVAFDA 182 Query: 656 AQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPY 835 A+ GK K+ + KA ++ S L+ + ++ +YP++ +DNA +++V P + Sbjct: 183 ARKRGK-KLVSIDKANVLSTSV-LWREVVERVSADYPDVVLSHMYVDNAAMQLVKAPKQF 240 Query: 836 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAPDIAGKGLANP 1012 + VL+ PN++GDILSD A L G LG+ PS ++ + ++E GSAPDIAGK +ANP Sbjct: 241 D--VLLCPNMFGDILSDEAAMLTGSLGMLPSASLAEGSFGMYEPAGGSAPDIAGKNIANP 298 Query: 1013 TALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS+ M+L++ GL + A+ ++ A+ LA G TGD+ Sbjct: 299 VAQILSAAMLLRYSCGLADAADAVEKAVENCLAAGLR-TGDI 339
>Q9EVG6:LEU3_BUCUA 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Uroleucon aeneum Length = 363 Score = 126 bits (316), Expect = 2e-28 Identities = 100/367 (27%), Positives = 184/367 (50%), Gaps = 34/367 (9%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIA 355 KY ++++ GDGIGPE+ + I + ++P++ + ++ + +P +++ Sbjct: 4 KYRIAVLPGDGIGPEVMREAYKILNILKDDFSLPLEIKEFNIGGAAIDQEGVALPKKTLL 63 Query: 356 SIKRNYVALKGPLA------TPIGKGHVSLNLT-LRRTFNLFANVRPCKSIQGYK--TPY 508 + + L G + PI + +L LR+ FNLFAN+RP + K +P Sbjct: 64 GCENSDAILFGSVGGKKWDNLPINQRPERASLLPLRKHFNLFANLRPAQLYSELKNLSPL 123 Query: 509 ------DNVDTVLIRENTEGEYSG----------IEHVVVDGVVQSIKLITREASERVLR 640 + + + IRE T G Y G IE+ + + ++ R+ Sbjct: 124 RSNIIKNGFNILCIRELTGGIYFGKPTGRLKKNNIEYAFDTEIYYNYEI------NRIAH 177 Query: 641 FAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVT 820 AFQ +Q KV + K+ ++ S L+ + ++++K YP++ +DNA ++++ Sbjct: 178 LAFQLSQTRNY-KVCSIDKSNVLNSSI-LWREIVKKVSKHYPDVHLSHLYIDNATMQIIK 235 Query: 821 DPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGD-ECSIFEAVHGSAPDIAGK 997 DP ++ VL+ NL+GDI+SD CA + G +G+ PS ++ + + ++E GSAPDI GK Sbjct: 236 DPNQFD--VLLCSNLFGDIISDECAMITGSIGMLPSASLNEKKFGLYEPAGGSAPDIEGK 293 Query: 998 GLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKS---KTHEYA 1165 +ANP A +LS M++++ M L + A+KI ++ L +G T D+ + KT+E Sbjct: 294 NIANPIAQILSLSMLVRYSMNLKKIADKIDQSVISVLKKGYR-TADISNNNDYLKTNEMG 352 Query: 1166 AAVIKNL 1186 + L Sbjct: 353 DVIASAL 359
>Q3SHL3:LEU3_THIDA 3-isopropylmalate dehydrogenase - Thiobacillus denitrificans (strain| ATCC 25259) Length = 353 Score = 125 bits (315), Expect = 3e-28 Identities = 103/338 (30%), Positives = 175/338 (51%), Gaps = 25/338 (7%) Frame = +2 Query: 197 VSLIEGDGIGPEI-AQSVK--DIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKR 367 ++++ GDGIGPEI +Q+VK + + I+ E+ + + +P+ ++ + Sbjct: 3 IAVLPGDGIGPEIISQAVKVLEALKSEGAKIEMETAPIGGAGYDAAGDPLPEATLKLARE 62 Query: 368 NYVALKGPLATPIGKGHVSLN---------LTLRRTFNLFANVRPC------KSIQGYKT 502 L G + P + +L+ L +R+ NLFAN+RP S K Sbjct: 63 ADAVLLGAVGGP---QYDTLDRPLRPERGLLRIRKELNLFANLRPALLYPELASASSLKP 119 Query: 503 PY-DNVDTVLIRENTE----GEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDI 667 +D +++RE T G+ GIE + V + L + RV AF A Sbjct: 120 EVVSGLDLMIVRELTGDVYFGQPRGIETRNGERVGFNTMLYSESEVRRVAHVAFGIAMKR 179 Query: 668 GKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKV 847 GK K+ V KA +++ S+ L+ + E+AK+YP +E +DNA ++++ P ++ Sbjct: 180 GK-KLCSVEKANVLECSE-LWKEIMIEVAKDYPEVELSHMYVDNAAMQLIRAPKQFD--T 235 Query: 848 LVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECS-IFEAVHGSAPDIAGKGLANPTALL 1024 +V N++GDILSD + L G +G+ PS ++ + ++E +HGSAPDIAGK LANP A + Sbjct: 236 IVTGNIFGDILSDAASMLSGSIGMLPSASLDEHNKGMYEPIHGSAPDIAGKNLANPLATI 295 Query: 1025 LSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 LS MM ++ A++I+ A+ + +A+G TGD+ Sbjct: 296 LSVAMMYRYTFADLATADRIENAVKQVIAKGYR-TGDI 332
>Q2JL30:LEU3_SYNJB 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain| JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) Length = 371 Score = 125 bits (315), Expect = 3e-28 Identities = 105/332 (31%), Positives = 170/332 (51%), Gaps = 24/332 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWESIDVTPSLNADGKTVIPDESIAS 358 Y ++ + GDGIGPEI + + + A ++W+ + + +P E++ Sbjct: 11 YRITALAGDGIGPEIMRVGRAVLDAVARQMGFALQWQEGLIGGAAYDQTGDPLPAETLKM 70 Query: 359 IKRN---YVALKGPL---ATPIGKGHVSLNLTLRRTFNLFANVRPCK---SIQGYKTPYD 511 + + Y+A G A P K L LR LFAN+RP K + G + Sbjct: 71 AQESDAVYLAAVGDFKYDALPPEKRPERALLGLRAGLGLFANLRPVKVFPQLVGASSLKP 130 Query: 512 NV----DTVLIRENTEGEYSGIEHVVVDGVVQSIK----LITREAS-ERVLRFAFQYAQD 664 V D V++RE T G Y G + S + ++ EA +R+ R AF+ A+ Sbjct: 131 EVIAGIDLVVVRELTGGIYFGQPKGIFTDAQGSRRGVNTMVYSEAEVDRIARVAFELARK 190 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 + K+ V KA ++++S L+ IA EYP +E +DNA +++V P ++ Sbjct: 191 -RRRKLCSVDKANVLEVSQ-LWRERVNAIAAEYPEVELSHLYIDNAAMQLVRWPKQFD-- 246 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTAL 1021 V++ NL+GDILSD A L G +G+ PS ++G ++E VHGSAPDIAG+ ANP A Sbjct: 247 VILTGNLFGDILSDEAAMLTGSIGMLPSASLGSSGPGLYEPVHGSAPDIAGQDKANPIAQ 306 Query: 1022 LLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 +LS +ML++ + + A++I+ A+ LA+G Sbjct: 307 VLSGALMLRYSLDQPQAADRIEQAVEAVLAQG 338
>Q2JTN8:LEU3_SYNJA 3-isopropylmalate dehydrogenase - Synechococcus sp. (strain JA-3-3Ab)| (Cyanobacteria bacterium Yellowstone A-Prime) Length = 381 Score = 125 bits (315), Expect = 3e-28 Identities = 103/332 (31%), Positives = 168/332 (50%), Gaps = 24/332 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPI----KWESIDVTPSLNADGKTVIPDESIAS 358 Y ++ + GDGIGPEI Q + + A + +W+ + + +P E++ Sbjct: 11 YRITALAGDGIGPEIMQVGRAVLDAVAAQVGFSLQWQEGLIGGAAYEATGDPLPPETLKM 70 Query: 359 IKRN---YVALKGPL---ATPIGKGHVSLNLTLRRTFNLFANVRPCKS----IQGYKTPY 508 + + Y+A G P K L LR LFAN+RP K +Q Sbjct: 71 AQESDAVYLAAVGDFKYDTLPREKRPERALLGLRAGLGLFANLRPVKIFPQLVQASSLKP 130 Query: 509 D---NVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREAS-----ERVLRFAFQYAQD 664 + +D V++RE T G Y G + S + + A +R+ R AF+ A+ Sbjct: 131 EVVAGIDLVVVRELTGGIYFGQPKGIFTDAKGSRRGVNTMAYSEAEVDRIARVAFELARK 190 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 + K+ V KA ++++S L+ IA EYP++E +DNA +++V P ++ Sbjct: 191 -RRRKLCSVDKANVLEVSQ-LWRERVTAIAAEYPDVELSHLYVDNAAMQLVRWPKQFD-- 246 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPTAL 1021 V++ NL+GDILSD A L G +G+ PS ++G ++E VHGSAPDIAG+ ANP A Sbjct: 247 VILTENLFGDILSDEAAMLTGSIGMLPSASLGSSGPGVYEPVHGSAPDIAGQDKANPIAQ 306 Query: 1022 LLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 +LS M+L++ + + A++I+ A+ LA+G Sbjct: 307 VLSGAMLLRYSLDQPQAADRIEQAVEAVLAQG 338
>Q7UIE1:LEU3_RHOBA 3-isopropylmalate dehydrogenase - Rhodopirellula baltica| Length = 359 Score = 125 bits (315), Expect = 3e-28 Identities = 105/365 (28%), Positives = 176/365 (48%), Gaps = 34/365 (9%) Frame = +2 Query: 194 TVSLIEGDGIGPEIAQSVKDI-----------YSAANVPIKWESIDVTPSLNADGKTVIP 340 ++ L+ GDGIGPEI + + + + ++ I +ID T +P Sbjct: 4 SIVLLPGDGIGPEIVEQARLVLVKVAERFGHTFDFSSHQIGGIAIDETGD-------PLP 56 Query: 341 DESIASIKRNYVALKGPLATPIGKGHVSLN------LTLRRTFNLFANVRPCKSIQGYKT 502 +I + + L G + P + L +R+ LFAN+RP K Sbjct: 57 QPTIDACRNAAAILLGAVGGPKWDDPSAKTRPEAGLLKIRKELGLFANLRPIKLFDELAD 116 Query: 503 P-------YDNVDTVLIRENTEGEYSGIEHVVVDGVVQS-IKLITREASE--RVLRFAFQ 652 D + RE T G Y G G ++ + +T E R++R A Q Sbjct: 117 ASPLRADIVKGTDILFFRELTGGIYFGESGTSGSGEEETAFQSMTYSVGEVKRIVRMAAQ 176 Query: 653 YAQDIGKPKVRVVHKATIMKMSDGLFLNLGREI-AKEYPNIEFDAELLDNACLKVVTDPT 829 A+ ++ V KA +++ S L+ + E+ A E+P++++D L+D+ + ++ P+ Sbjct: 177 AARGRSN-RLTSVDKANVLEPSR-LWRRVAAEVMANEFPDVQYDVVLVDSMAMHLINRPS 234 Query: 830 PYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLA 1006 ++ V+V N++GDIL+D + L G LG+ PS ++GD ++E +HGSAPDIAGK +A Sbjct: 235 EFD--VVVTGNMFGDILTDEASMLPGSLGMLPSASLGDGGPGLYEPIHGSAPDIAGKSVA 292 Query: 1007 NPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG----KTITGDLGGKSKTHEYAAA 1171 NP A +L++ MML+H +GL + A I+ A+ + +G GD T E AA Sbjct: 293 NPLATILAAAMMLRHSLGLTDEAEAIEKAVAGVITDGLRTPDLARGDQSKSVSTEEMGAA 352 Query: 1172 VIKNL 1186 V+ L Sbjct: 353 VVAKL 357
>Q4KF05:LEU3_PSEF5 3-isopropylmalate dehydrogenase - Pseudomonas fluorescens (strain| Pf-5 / ATCC BAA-477) Length = 360 Score = 125 bits (315), Expect = 3e-28 Identities = 114/358 (31%), Positives = 176/358 (49%), Gaps = 28/358 (7%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAAN--VPIKWE-SIDVTPSLNADGKTV-IPDESIASIK 364 + ++ GDGIGPEI + AN + +E S DV D V + DE++ + Sbjct: 5 ILILPGDGIGPEIMAEAVKVLELANDKYSLGFELSHDVIGGAAIDKHGVPLADETLDRAR 64 Query: 365 RNYVALKGPLATPI-GKGHVSLN-----LTLRRTFNLFANVRPC------KSIQGYKTPY 508 L G + P K + L +R LF N+RP K Sbjct: 65 AADAVLLGAVGGPKWDKIERDIRPERGLLKIRAQLGLFGNLRPAILYPQLADASSLKPEI 124 Query: 509 -DNVDTVLIRENTEGEYSGIEH---VVVDGVVQSIKLITREASE--RVLRFAFQYAQDIG 670 +D +++RE T G Y G + +G QS + SE R+ R F A+ G Sbjct: 125 VSGLDILIVRELTGGIYFGAPRGTRELENGERQSYDTLPYSESEIRRIARVGFDMARVRG 184 Query: 671 KPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVL 850 K K+ V KA ++ S L+ + ++AK+YP++E +DNA +++V P ++ V+ Sbjct: 185 K-KLCSVDKANVLASSQ-LWREVVEQVAKDYPDVELSHMYVDNAAMQLVRAPKQFD--VI 240 Query: 851 VMPNLYGDILSDMCAGLIGGLGLTPSGNI-GDECSIFEAVHGSAPDIAGKGLANPTALLL 1027 V N++GDILSD + L G +G+ PS ++ + ++E HGSAPDIAG+G+ANP A +L Sbjct: 241 VTDNMFGDILSDEASMLTGSIGMLPSASLDANNKGMYEPCHGSAPDIAGQGIANPLATIL 300 Query: 1028 SSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGG----KSKTHEYAAAVIKNL 1186 S MML++ L E A+ I+ A+ + L +G TGD+ K T E AV+ L Sbjct: 301 SVSMMLRYSFNLTEAADAIEQAVSRVLDQGLR-TGDIWSAGCTKVGTQEMGDAVVAAL 357
>Q8XXX5:LEU3_RALSO 3-isopropylmalate dehydrogenase - Ralstonia solanacearum (Pseudomonas| solanacearum) Length = 356 Score = 125 bits (314), Expect = 4e-28 Identities = 106/337 (31%), Positives = 166/337 (49%), Gaps = 24/337 (7%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 ++++ GDGIG EI + + E+ V + +P++++ K Sbjct: 4 IAVLPGDGIGTEIVAEAVKVLKTLGETFEMETAPVGGAGYEAKGHPLPEDTLKLAKEADA 63 Query: 377 ALKGPLAT------PIGKGHVSLNLTLRRTFNLFANVRPC---KSIQGYKTPYDNV---- 517 L G + P L LR+ LFAN RP + G + + Sbjct: 64 ILFGAVGDWKYDTLPRELRPEQAILGLRKHLQLFANFRPAICYPELAGASSMKPEIVAGL 123 Query: 518 DTVLIRENTEGEYSGIEHVV---VDGVVQSIK--LITREASE----RVLRFAFQYAQDIG 670 D +++RE T Y G V DG+ + T SE R+ AFQ A G Sbjct: 124 DILIVRELTGDIYFGQPRGVRAAPDGLFAGAREGFDTMRYSEPEIRRIAHVAFQAAAKRG 183 Query: 671 KPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVL 850 K K+ V KA +++ + ++ ++ KEYP +E +DNA +++V P N V+ Sbjct: 184 K-KLCSVDKANVLETFQ-FWKDIVTDVHKEYPEVELSHMYVDNAAMQLVK--APKNFDVV 239 Query: 851 VMPNLYGDILSDMCAGLIGGLGLTPSGNI-GDECSIFEAVHGSAPDIAGKGLANPTALLL 1027 V N++GDILSD A L G +G+ PS ++ + ++E HGSAPDIAGKG+ANP A +L Sbjct: 240 VTGNMFGDILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGIANPLATIL 299 Query: 1028 SSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 S+ MML++ +G E A++I+ A+ K LA+G TGD+ Sbjct: 300 SAAMMLRYTLGKAEQADRIENAVKKVLAQGYR-TGDI 335
>Q46YW0:LEU3_RALEJ 3-isopropylmalate dehydrogenase - Ralstonia eutropha (strain JMP134)| (Alcaligenes eutrophus) Length = 355 Score = 125 bits (313), Expect = 5e-28 Identities = 108/341 (31%), Positives = 176/341 (51%), Gaps = 28/341 (8%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPS-LNADGKTVIPDESIASIKRNY 373 ++++ GDGIGPEI + +A + + E+ V + A+G +P+ ++ K Sbjct: 3 IAVLPGDGIGPEIVAEAVKVLNALDEKFEMETAPVGGAGYEAEGHP-LPENTLKLAKEAD 61 Query: 374 VALKGPLATPIGKGHVSLN---------LTLRRTFNLFANVRPC---KSIQGYKTPYDNV 517 L G + + SL L LR+ LFAN RP + G + + Sbjct: 62 AILFGAVGD---WKYDSLERALRPEQAILGLRKHLQLFANFRPAICYPELTGASSLKPEL 118 Query: 518 ----DTVLIRENTEGEYSGIEHVV---VDGVVQSIK--LITREASE----RVLRFAFQYA 658 D +++RE Y G V DG+ + + T SE R+ AFQ A Sbjct: 119 VAGLDILIVRELNGDIYFGQPRGVREAPDGLFKGAREGFDTMRYSEPEIRRIAHVAFQAA 178 Query: 659 QDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYN 838 GK K+ V KA +++ + ++ +++KEYP++E +DNA +++V P ++ Sbjct: 179 AKRGK-KLCSVDKANVLETFQ-FWKDIVIDVSKEYPDVELSHMYVDNAAMQLVKAPKSFD 236 Query: 839 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNI-GDECSIFEAVHGSAPDIAGKGLANPT 1015 V+V N++GDILSD A L G +G+ PS ++ + ++E HGSAPDIAGKG+ANP Sbjct: 237 --VIVTGNMFGDILSDEAAMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGKGVANPL 294 Query: 1016 ALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 A +LS+ MML++ + E A++I+ A+ K LA+G TGD+ Sbjct: 295 ATILSAAMMLRYSLNKAEQADRIENAVKKVLAQGYR-TGDI 334
>Q3KF21:LEU3_PSEPF 3-isopropylmalate dehydrogenase - Pseudomonas fluorescens (strain| PfO-1) Length = 360 Score = 125 bits (313), Expect = 5e-28 Identities = 115/359 (32%), Positives = 175/359 (48%), Gaps = 29/359 (8%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAAN--VPIKWE-SIDVTPSLNADGKTV-IPDESIASIK 364 + ++ GDGIGPEI + AN + +E S DV D V + DE++ + Sbjct: 5 ILILPGDGIGPEIMAEAVKVLELANEKYSLGFELSHDVIGGAAIDKHGVPLADETLDRAR 64 Query: 365 RNYVALKGPLATPIG-------KGHVSLNLTLRRTFNLFANVRPC------KSIQGYKTP 505 L G + P + L L +R LF N+RP K Sbjct: 65 AADAVLLGAVGGPKWDTIERDIRPERGL-LKIRAQLGLFGNLRPAILYPQLADASSLKPE 123 Query: 506 YD-NVDTVLIRENTEGEYSGIEH---VVVDGVVQSIKLITREASE--RVLRFAFQYAQDI 667 +D +++RE T G Y G + +G QS + SE R+ R F A+ Sbjct: 124 IAAGLDILIVRELTGGIYFGAPRGTRTLENGERQSYDTLPYSESEIRRIARVGFDMARVR 183 Query: 668 GKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKV 847 GK K+ V KA ++ S L+ + ++AK+YP++E +DNA +++V P ++ V Sbjct: 184 GK-KLCSVDKANVLASSQ-LWREVVEQVAKDYPDVELSHMYVDNAAMQLVRAPKQFD--V 239 Query: 848 LVMPNLYGDILSDMCAGLIGGLGLTPSGNI-GDECSIFEAVHGSAPDIAGKGLANPTALL 1024 +V N++GDILSD + L G +G+ PS ++ + ++E HGSAPDIAGKG+ANP A + Sbjct: 240 IVTDNMFGDILSDEASMLTGSIGMLPSASLDANNKGMYEPCHGSAPDIAGKGIANPLATI 299 Query: 1025 LSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGG----KSKTHEYAAAVIKNL 1186 LS MML++ L E A+ I+ A+ L +G TGD+ K T E AV+ L Sbjct: 300 LSVSMMLRYSFNLHEAADAIEKAVSVVLDQGLR-TGDIFSTGCTKVGTQEMGDAVVAAL 357
>Q89X19:LEU32_BRAJA 3-isopropylmalate dehydrogenase 2 - Bradyrhizobium japonicum| Length = 370 Score = 125 bits (313), Expect = 5e-28 Identities = 117/365 (32%), Positives = 184/365 (50%), Gaps = 37/365 (10%) Frame = +2 Query: 203 LIEGDGIGPEIAQSVKDIY----SAANVPIKWESIDVTPSLNADGKTVIPD----ESIAS 358 L+ GDGIGPE+ VK + SA + ++ V S K I + +++A+ Sbjct: 8 LLPGDGIGPEVMGEVKRLIDWLNSAGIAKFETDTGLVGGSAYDAHKVSISEGDMAKALAA 67 Query: 359 IKRNYVALKGPL--ATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY-------KTPYD 511 + A+ GP A P + L LR+ LFAN+RP + + Sbjct: 68 DAIIFGAVGGPKWDAVPYEVRPEAGLLRLRKDLGLFANLRPAVCYPALADASSLKREAVE 127 Query: 512 NVDTVLIRENTEGEYSGIEHVVVD---GVVQSI--KLITREASERVLRFAFQYAQDIGKP 676 +D +++RE T G Y G + D G ++I ++ ER+ R AF A+ K Sbjct: 128 GLDIMIVRELTGGVYFGEPKTITDLGNGQKRAIDTQVYDTYEIERIARVAFDLAKK-RKN 186 Query: 677 KVRVVHKATIMKMSDGLFLNLGREIAK-EYPNIEFDAELLDNACLKVVTDPTPYNDKVLV 853 KV + K +MK S L+ + ++ K EYP++ + +L D+ + +V P ++ V+V Sbjct: 187 KVTSMEKRNVMK-SGVLWNEVVTQVHKREYPDVTLEHQLADSGGMMLVKWPKQFD--VIV 243 Query: 854 MPNLYGDILSDMCAGLIGGLGLTPSGNIGD-------ECSIFEAVHGSAPDIAGKGLANP 1012 NL+GD+LSD+ A L G LG+ PS ++G+ +++E VHGSAPDIAGKGLANP Sbjct: 244 TDNLFGDMLSDIAAMLTGSLGMLPSASLGEVDVKSKKRKALYEPVHGSAPDIAGKGLANP 303 Query: 1013 TALLLSSIMMLQH---MGLFEHANKIQAAIFKTLAEGKTITGDLGGK----SKTHEYAAA 1171 A++ S M L++ MG A+K+ AAI LA G T D+ + + T + A Sbjct: 304 IAMISSFGMALRYSFDMGAL--ADKVDAAIAAVLASGLR-TADIKSEGTTAASTTQMGEA 360 Query: 1172 VIKNL 1186 ++K L Sbjct: 361 ILKEL 365
>Q56268:LEU3_THIFE 3-isopropylmalate dehydrogenase - Thiobacillus ferrooxidans| (Acidithiobacillus ferrooxidans) Length = 358 Score = 124 bits (312), Expect = 7e-28 Identities = 96/331 (29%), Positives = 168/331 (50%), Gaps = 25/331 (7%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 +++ GDGIGPEI + + + A + + T L D+ + + Sbjct: 4 IAIFAGDGIGPEIVAAARQVLDAVDQAAHL-GLRCTEGLVGGAALDASDDPLPAASLQLA 62 Query: 377 ---------ALKGPL--ATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYD---- 511 A+ GP A P K L LR+ +L+AN+RP + Sbjct: 63 MAADAVILGAVGGPRWDAYPPAKRPEQGLLRLRKGLDLYANLRPAQIFPQLLDASPLRPE 122 Query: 512 ---NVDTVLIRENTE----GEYSGIEHVVVDGVVQSIKLITREASE--RVLRFAFQYAQD 664 +VD +++RE T G+ G+E V+DG + + + E R+ AF+ AQ Sbjct: 123 LVRDVDILVVRELTGDIYFGQPRGLE--VIDGKRRGFNTMVYDEDEIRRIAHVAFRAAQG 180 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 K ++ V KA +++ + L+ + E+A++YP++ +DNA ++++ P ++ Sbjct: 181 RRK-QLCSVDKANVLETTR-LWREVVTEVARDYPDVRLSHMYVDNAAMQLIRAPAQFD-- 236 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALL 1024 VL+ N++GDILSD + L G +G+ PS ++G+ +++E +HGSAPDIAG+ ANP A + Sbjct: 237 VLLTGNMFGDILSDEASQLTGSIGMLPSASLGEGRAMYEPIHGSAPDIAGQDKANPLATI 296 Query: 1025 LSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 LS MML+H + A +++AA+ + L +G Sbjct: 297 LSVAMMLRHSLNAEPWAQRVEAAVQRVLDQG 327
>P73960:LEU3_SYNY3 3-isopropylmalate dehydrogenase - Synechocystis sp. (strain PCC 6803)| Length = 362 Score = 124 bits (312), Expect = 7e-28 Identities = 102/340 (30%), Positives = 175/340 (51%), Gaps = 25/340 (7%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKW-----ESIDVTPSLNADGKTVIPDESIA 355 Y V+L+ GDGIGPEI + + E++ +++A G+ +P+ ++A Sbjct: 5 YNVTLLPGDGIGPEIMAVAVAVLGKVADQFGFAFNFQEALIGGAAIDATGQP-LPEATLA 63 Query: 356 SIKRNYVALKGPLA------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGY------- 496 K + L + P + + L +R LFAN+RP Sbjct: 64 QAKDSDAVLLAAIGGYAWDNLPRSQRPETGLLAIREGLGLFANLRPATIFPQLIDASSLK 123 Query: 497 KTPYDNVDTVLIRENTEGEYSGIEHVVVD---GVVQSIKLITREASE--RVLRFAFQYAQ 661 + + VD +++RE T G Y G + + G + + + E R+ + AF+ A+ Sbjct: 124 REVVEGVDIMVVRELTGGIYFGKPKGIFETETGEKRGVNTMAYTVGEIDRIAKVAFETAR 183 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 + ++ V KA ++ +S L+ + IA +YP++E +DNA +++V P ++ Sbjct: 184 K-RRGQLCSVDKANVLDVSQ-LWRDRVMAIAVDYPDVELSHLYVDNAAMQLVRSPRQFD- 240 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIG-DECSIFEAVHGSAPDIAGKGLANPTA 1018 +V NL+GDILSD+ A L G +G+ PS ++G D +FE VHGSAPDIAG+ ANP A Sbjct: 241 -TIVTGNLFGDILSDIAAMLTGSIGMLPSASLGSDGPGLFEPVHGSAPDIAGQDKANPLA 299 Query: 1019 LLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 +LS+ MML++ + + A++++ A+ K L +G TGD+ Sbjct: 300 QVLSAAMMLRYGLDQPQAADRLEDAVKKVLEQGYR-TGDI 338
>Q21XI1:LEU3_RHOFD 3-isopropylmalate dehydrogenase - Rhodoferax ferrireducens (strain| DSM 15236 / ATCC BAA-621 / T118) Length = 356 Score = 124 bits (312), Expect = 7e-28 Identities = 109/360 (30%), Positives = 171/360 (47%), Gaps = 30/360 (8%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRNYV 376 ++++ GDGIG EI + +A ++ ++ E+ V + +PD ++ K Sbjct: 3 IAVLPGDGIGTEIVAEAVKVLNALDLKLEMETALVGGAAYEAFGHPLPDATLKLAKEADA 62 Query: 377 ALKGP--------LATPIGKGHVSLNLTLRRTFNLFANVRPCKSIQGYKTPYD------- 511 L G L P+ L L R+ LFAN RP + Sbjct: 63 VLFGAVGDWKYDKLDRPLRPEQAILGL--RKNLGLFANFRPAICYEQLVDASSLKPELIA 120 Query: 512 NVDTVLIRENTEGEYSGI---EHVVVDGVVQSIK------LITREASERVLRFAFQYAQD 664 +D ++IRE T Y G DG + +R ER+ AFQ A+ Sbjct: 121 GLDILIIRELTGDIYFGQPRGRRTATDGHFPGAEEAFDTMRYSRPEIERIAHVAFQAARK 180 Query: 665 IGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDK 844 K +V V KA +++ + ++ E+ ++YP++E D +DNA +++V P ++ Sbjct: 181 RSK-RVTSVDKANVLETFQ-FWRDVLTEVGQQYPDVELDHMYVDNAAMQLVRAPKKFD-- 236 Query: 845 VLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECS-IFEAVHGSAPDIAGKGLANPTAL 1021 V+V NL+GDILSD A L G +G+ PS ++ ++E HGSAPDIAGKG+ANP A Sbjct: 237 VVVTGNLFGDILSDEAAMLTGSIGMLPSASLNASSQGLYEPSHGSAPDIAGKGVANPLAT 296 Query: 1022 LLSSIMMLQ-HMGLFEHANKIQAAIFKTLAEGKTITGDLGGKSKTH----EYAAAVIKNL 1186 +LS+ MML+ + A +I+AA+ L +G T D+ T E AAV+K L Sbjct: 297 ILSAAMMLRFSLNQEVAAQRIEAAVKDVLVQGLR-TADIFSTGTTRVSTVEMGAAVVKAL 355
>Q7V1R9:LEU3_PROMP 3-isopropylmalate dehydrogenase - Prochlorococcus marinus subsp.| pastoris (strain CCMP 1378 / MED4) Length = 357 Score = 124 bits (312), Expect = 7e-28 Identities = 106/347 (30%), Positives = 168/347 (48%), Gaps = 38/347 (10%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQ-----------------SVKD------IYSAANVPIKWESID 298 +Y V L+ GDGIGPEI++ +K+ Y N P E++D Sbjct: 3 RYKVVLLSGDGIGPEISEISITILKKLSKKYGFNLDIKEEYFGGIAYEKHNDPAPKETLD 62 Query: 299 VTPSLNADGKTVIPDESIASIKRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPC 478 + +A + D ++ R G L LR NLFAN+RP Sbjct: 63 QCKASDAVLLACVGDVKYDTLPRELRPESG-------------LLKLREALNLFANIRPV 109 Query: 479 K-------SIQGYKTPYDNVDTVLIRENTEGEYSG-----IEHVVVDGVVQSIKLITREA 622 K S K +NVD +++RE G Y G I + ++ + E Sbjct: 110 KIRKSLLDSSSFKKEVIENVDLIVVRELIGGIYFGQPRGEITQTKIKKAFNTMVYDSNEI 169 Query: 623 SERVLRFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNA 802 ER+ A + A K K+ V K+ ++++S L+ + +A + ++ +DNA Sbjct: 170 -ERITEVAIKIANQRSK-KICSVDKSNVLEVSQ-LWRDTVSLVASKENDLALSNMYVDNA 226 Query: 803 CLKVVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSA 979 +++V DP ++ V++ NL+GDILSD+ A + G +G+ PS ++ + +FE VHGSA Sbjct: 227 AMQLVKDPGQFD--VILTSNLFGDILSDLAAMITGSIGMLPSASLSNSGPGVFEPVHGSA 284 Query: 980 PDIAGKGLANPTALLLSSIMMLQHMGL--FEHANKIQAAIFKTLAEG 1114 PDIAGK +ANP A+ LS+ MML+ +GL E A+ I+ AI L++G Sbjct: 285 PDIAGKNIANPIAMALSTSMMLK-IGLNEIEAADDIEIAIDNVLSKG 330
>Q5WPZ9:LEU3_BUCCC 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp. Cinara| cedri Length = 367 Score = 124 bits (312), Expect = 7e-28 Identities = 99/340 (29%), Positives = 173/340 (50%), Gaps = 31/340 (9%) Frame = +2 Query: 188 KYTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTV------IPDES 349 +Y ++++ GDGIGPE+ Q I + N K++ T + G + +P ++ Sbjct: 6 EYRIAVLPGDGIGPEVMQEAYKILNVINK--KFDFNIYTNEYDIGGIAIDKYGAPLPKKT 63 Query: 350 IASIKRNYVALKGPLATPIGKGHVSLN----------LTLRRTFNLFANVRPCKSIQGYK 499 + ++ L G + GK L L LR+ FNLF N+RP K K Sbjct: 64 LNGCIESHAILFGSIG---GKEWTHLPADEQPERGGLLPLRKFFNLFVNLRPIKLHFSLK 120 Query: 500 --TPY------DNVDTVLIRENTEGEYSGIEHVVVDGVVQSI-----KLITREASERVLR 640 +P D D + +RE G Y G+ ++I ++ + + E++ Sbjct: 121 KLSPLKKEIIQDGFDILCVRELIGGIYFGLPKGKNTFDKKNISAFDTEIYSTKEIEKIAD 180 Query: 641 FAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVT 820 AFQ + K KV + KA +++ S L+ + +++K YPN+E +DNA ++++ Sbjct: 181 IAFQLSLK-RKKKVFSIDKANVLE-SSMLWREVVIQVSKRYPNVELIHLYIDNAAMQLIK 238 Query: 821 DPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGK 997 +P ++ V++ NL+GDILSD CA L G LG+ PS ++ + +FE GSAPD+ GK Sbjct: 239 NPNQFD--VILCSNLFGDILSDECAALTGSLGMLPSASLNESFFGLFEPAGGSAPDLKGK 296 Query: 998 GLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 +ANP A +LS ++ ++ + L + ++ I+ ++ KTL +G Sbjct: 297 NIANPIAQILSLALLFKYSLQLEKISHLIELSVLKTLEKG 336
>P56933:LEU3_BUCAI 3-isopropylmalate dehydrogenase - Buchnera aphidicola subsp.| Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) Length = 363 Score = 124 bits (312), Expect = 7e-28 Identities = 105/363 (28%), Positives = 176/363 (48%), Gaps = 31/363 (8%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVIPDESIASIKRN 370 Y ++++ GDGIGPE+ Q I NV K+ + + G I E +A K Sbjct: 5 YRIAVLSGDGIGPEVMQEACKIL---NVLKKYFFLSLEIQKFNIGGIAIEREGVALPKTT 61 Query: 371 YVALKGPLATPIG--------------KGHVSLNLTLRRTFNLFANVRPCKSIQGYK--T 502 + + + +G + + L LR+ FNLF+N+RP K K + Sbjct: 62 LLGCENSDSILLGSVGGKKWDNLPVEQRPERAALLPLRKHFNLFSNLRPAKLYPELKCLS 121 Query: 503 PY------DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASE----RVLRFAFQ 652 P + D + +RE T G Y G V+ T E R+ AF+ Sbjct: 122 PLRSDIVKNGFDILCVRELTGGIYFGEPKGFVNKNNTKYAFDTEIYHEYEIIRIAHLAFK 181 Query: 653 YAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTP 832 A+ K KV + K+ +++ S L+ + ++K+YP++ +DNA ++++ DP Sbjct: 182 LARS-RKKKVCSIDKSNVLQSSI-LWREVVESVSKKYPDVHLSHLYIDNAAMQIIKDPNQ 239 Query: 833 YNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLAN 1009 ++ VL+ NL+GDI+SD CA + G +G+ PS + ++ ++E GSAPDI GK +AN Sbjct: 240 FD--VLLCSNLFGDIISDECATITGSIGMLPSASFNEKNFGLYEPAGGSAPDIEGKNIAN 297 Query: 1010 PTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDLGGKS---KTHEYAAAVI 1177 P A +LS M++++ M L + A+KI A+ L +G T D+ + KT E ++ Sbjct: 298 PIAQILSLSMLVRYGMNLNQIADKIDKAVNNVLKKGYR-TSDISHDNNFLKTDEMGDLIV 356 Query: 1178 KNL 1186 +L Sbjct: 357 DSL 359
>P54354:LEU3_BACFR 3-isopropylmalate dehydrogenase - Bacteroides fragilis| Length = 353 Score = 124 bits (312), Expect = 7e-28 Identities = 101/351 (28%), Positives = 174/351 (49%), Gaps = 22/351 (6%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWE-SIDVTPSLNADGKTVIPDESIA 355 + ++++ GDGIGPEI+ ++ SA + +E +I +++ G P+E+ Sbjct: 3 FKIAVLAGDGIGPEISVQGVEVMSAVCEKFGHKVNYEYAICGADAIDKVGDP-FPEETYR 61 Query: 356 SIKRNYVALKGPLATPIGKGHVSLN-------LTLRRTFNLFANVRPCKSIQG--YKTPY 508 K L + P + L +R+ LFAN+RP ++ + +K+P Sbjct: 62 VCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKSPL 121 Query: 509 -----DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGK 673 + D + IRE T G Y G ++ D + + TR ER+L+ F+YA K Sbjct: 122 RAELVEGADFLCIRELTGGMYFGEKYQDNDKAYDT-NMYTRPEIERILKVGFEYAMKRRK 180 Query: 674 PKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLV 853 + VV KA ++ S L+ + +E+A +YP + D +DNA +K++ +P ++ V+V Sbjct: 181 -HLTVVDKANVLA-SSRLWRQIAQEMAPQYPEVTTDYMFVDNAAMKMIQEPKFFD--VMV 236 Query: 854 MPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 N +GDIL+D + + G +GL PS + G+ +FE +HGS P G +ANP A +LS Sbjct: 237 TENTFGDILTDEGSVISGSMGLLPSASTGESTPVFEPIHGSWPQAKGLNIANPLAQILSV 296 Query: 1034 IMMLQHMGLFEHANKIQAAIFKTL-AEGKT--ITGDLGGKSKTHEYAAAVI 1177 M+ ++ I+ A+ +L A +T I + G K T E A ++ Sbjct: 297 AMLFEYFDCKAEGALIRKAVDASLDANVRTPEIQVEGGEKFGTKEVGAWIV 347
>Q5LAB4:LEU3_BACFN 3-isopropylmalate dehydrogenase - Bacteroides fragilis (strain ATCC| 25285 / NCTC 9343) Length = 353 Score = 124 bits (312), Expect = 7e-28 Identities = 101/351 (28%), Positives = 174/351 (49%), Gaps = 22/351 (6%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAA----NVPIKWE-SIDVTPSLNADGKTVIPDESIA 355 + ++++ GDGIGPEI+ ++ SA + +E +I +++ G P+E+ Sbjct: 3 FKIAVLAGDGIGPEISVQGVEVMSAVCEKFGHKVNYEYAICGADAIDKVGDP-FPEETYR 61 Query: 356 SIKRNYVALKGPLATPIGKGHVSLN-------LTLRRTFNLFANVRPCKSIQG--YKTPY 508 K L + P + L +R+ LFAN+RP ++ + +K+P Sbjct: 62 VCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKSPL 121 Query: 509 -----DNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGK 673 + D + IRE T G Y G ++ D + + TR ER+L+ F+YA K Sbjct: 122 RAELVEGADFLCIRELTGGMYFGEKYQDNDKAYDT-NMYTRPEIERILKVGFEYAMKRRK 180 Query: 674 PKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYNDKVLV 853 + VV KA ++ S L+ + +E+A +YP + D +DNA +K++ +P ++ V+V Sbjct: 181 -HLTVVDKANVLA-SSRLWRQIAQEMAPQYPEVTTDYMFVDNAAMKMIQEPKFFD--VMV 236 Query: 854 MPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSS 1033 N +GDIL+D + + G +GL PS + G+ +FE +HGS P G +ANP A +LS Sbjct: 237 TENTFGDILTDEGSVISGSMGLLPSASTGESTPVFEPIHGSWPQAKGLNIANPLAQILSV 296 Query: 1034 IMMLQHMGLFEHANKIQAAIFKTL-AEGKT--ITGDLGGKSKTHEYAAAVI 1177 M+ ++ I+ A+ +L A +T I + G K T E A ++ Sbjct: 297 AMLFEYFDCKAEGALIRKAVDASLDANVRTPEIQVEGGEKFGTKEVGAWIV 347
>Q67JY2:LEU3_SYMTH 3-isopropylmalate dehydrogenase - Symbiobacterium thermophilum| Length = 368 Score = 124 bits (311), Expect = 9e-28 Identities = 104/342 (30%), Positives = 172/342 (50%), Gaps = 34/342 (9%) Frame = +2 Query: 191 YTVSLIEGDGIGPEIAQSVKDIYSAANVPIKW-----ESIDVTPSLNADGKTVIPDESIA 355 Y ++ + GDGIGPE+ + + AA + E + + +A G T PDE+ Sbjct: 6 YHIACLPGDGIGPEVTRGAVTVLQAAAAAYGFRLEFSEYLVGGAAYDAVG-TPFPDETRD 64 Query: 356 SIKRNYVALKGPLATPIGKG-------HVSLNLTLRRTFNLFANVRPCKSIQGYK--TPY 508 + R L G + P +G L L +R+ ++L+AN+RP K +P Sbjct: 65 ACDRADAILFGAVGGPRYEGLPWDLRPEAGL-LAIRKRYDLYANLRPILLYPPLKDASPL 123 Query: 509 DN------VDTVLIRENTEGEY----SGIEHVVVDGVVQSI--KLITREASERVLRFAFQ 652 N VD +++RE G Y GIE + DG + + ++ T R+ R F+ Sbjct: 124 KNEIIGGGVDFIIVRELVGGIYFGEPRGIE-TLPDGTRRGVNTEVYTDAEIARIARMGFE 182 Query: 653 YAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTP 832 A+ + ++ V K +M+ L+ + E+A+E+P++E + L DNA ++++ P Sbjct: 183 IARG-RRRRLTSVDKGNVMEAGK-LWRTVVDEVAREFPDVEVEHLLADNAAMQILRRPGD 240 Query: 833 YNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIF-------EAVHGSAPDIA 991 ++ V++ NL+GD LSD A L G +GL PS ++G + F E +HGSAPDIA Sbjct: 241 FD--VMLASNLFGDFLSDEAAMLTGSIGLLPSASLGAARNRFGLPKGFYEPIHGSAPDIA 298 Query: 992 GKGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG 1114 G+ ANP A +L M+L+H +G + A ++ A+ L EG Sbjct: 299 GQDRANPLAAILCGAMLLRHSLGREDAARAVEQAVAAVLEEG 340
>Q2SJD6:LEU3_HAHCH 3-isopropylmalate dehydrogenase - Hahella chejuensis (strain KCTC| 2396) Length = 360 Score = 124 bits (310), Expect = 1e-27 Identities = 110/360 (30%), Positives = 178/360 (49%), Gaps = 30/360 (8%) Frame = +2 Query: 197 VSLIEGDGIGPEIAQSVKDIYSAANVPIKWESIDVTPSLNADGKTVI-------PDESIA 355 V ++ GDGIGPEI +++ N S+ +T + G I P+E++A Sbjct: 5 VLILPGDGIGPEIVAQARNVLDVVNNKF---SLGLTFTEGLVGGAAIDTTGVPFPEETLA 61 Query: 356 SIKRNYVALKGPLATPI-GKGHVSLN-----LTLRRTFNLFANVRPC-------KSIQGY 496 + + L G + P K +++ L LR LFAN+RP ++ Sbjct: 62 TAEAADAILLGAVGGPKWDKLDMAIRPEKGLLGLRSGLELFANLRPAILYPQLAEASSLR 121 Query: 497 KTPYDNVDTVLIRENTEGEYSGIEHVV---VDGVVQSIKLITREASE--RVLRFAFQYAQ 661 +D +++RE T G Y G V +G + SE R+ R AF+ AQ Sbjct: 122 PEVVAGLDILIVRELTGGIYFGKPRGVRTLENGEREGFNTYVYSESEIRRIGRVAFEAAQ 181 Query: 662 DIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVVTDPTPYND 841 K ++ V KA +++++ L+ + E+AKEYP++E +DNA +++V P ++ Sbjct: 182 KRNK-RLCSVDKANVLEVTV-LWREVMDELAKEYPDVELSHMYVDNAAMQLVRAPKQFD- 238 Query: 842 KVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECS-IFEAVHGSAPDIAGKGLANPTA 1018 V+V N++GDILSD A L G +G+ PS ++ ++E HGSAPDIAG+ +ANP A Sbjct: 239 -VIVTGNMFGDILSDEAAMLTGSIGMLPSASLNAAGKGMYEPCHGSAPDIAGQNMANPLA 297 Query: 1019 LLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEG---KTITGDLGGKSKTHEYAAAVIKNL 1186 +LS+ MML++ + + A I+ A+ L +G + I G G T AV + L Sbjct: 298 TILSAAMMLRYSLAAEDAAAAIEQAVSDVLDQGLRTRDIAGSSGESVSTQAMGEAVARVL 357
>Q7NFH4:LEU3_GLOVI 3-isopropylmalate dehydrogenase - Gloeobacter violaceus| Length = 362 Score = 124 bits (310), Expect = 1e-27 Identities = 106/348 (30%), Positives = 170/348 (48%), Gaps = 31/348 (8%) Frame = +2 Query: 185 GKYTVSLIEGDGIGPEIAQSVKDIYSAA-----------NVPIKWESIDVTPSLNADGKT 331 G+Y ++++ GDGIG EI Q + AA PI +ID T Sbjct: 3 GRYKIAVLPGDGIGTEIVQVGVAMLEAAARRFDFAFDFEEAPIGGAAIDATGE------- 55 Query: 332 VIPDESIASIKRNYVALKGPLA------TPIGKGHVSLNLTLRRTFNLFANVRPCKSIQG 493 +P ++ K + G + P K L LR LFAN+RP + + Sbjct: 56 PLPAATLELCKASDAVFLGAVGGPQWDTLPSDKRPEKALLGLRAGLGLFANLRPARILPQ 115 Query: 494 YKTP-------YDNVDTVLIRENTEGEYSGIEHVVVD---GVVQSIKLITREASE--RVL 637 + VD +++RE T G Y GI + G + + ++ A E R+ Sbjct: 116 LVAASALKPEVVEGVDILVVRELTGGLYFGIPKGIFPEKKGGRRGVNTMSYSAFEIERIG 175 Query: 638 RFAFQYAQDIGKPKVRVVHKATIMKMSDGLFLNLGREIAKEYPNIEFDAELLDNACLKVV 817 R AF+ A++ + K+ V KA ++++S L+ + +A EYP++E +DN +++V Sbjct: 176 RVAFEAARE-RRGKLCSVDKANVLEVSQ-LWREVLVGLAPEYPDVELTHMYVDNCAMQLV 233 Query: 818 TDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAG 994 P ++ +V N++GDILSD A L G +G+ PS ++G ++E VHGSAPDIAG Sbjct: 234 RRPRQFD--TIVTENMFGDILSDEAAMLTGSIGMLPSASLGSGGPGLYEPVHGSAPDIAG 291 Query: 995 KGLANPTALLLSSIMMLQH-MGLFEHANKIQAAIFKTLAEGKTITGDL 1135 + ANP A +LS M+L+H + E A ++ A+ L +G TGD+ Sbjct: 292 QDKANPLAQVLSGAMLLRHSLRQPEAAQAVERAVQTVLEQGYR-TGDI 338 Database: uniprot_sprot.fasta.out Posted date: Jul 19, 2007 5:58 PM Number of letters in database: 100,686,439 Number of sequences in database: 274,295 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 274295 Number of Hits to DB: 214,908,769 Number of extensions: 4808153 Number of successful extensions: 19518 Number of sequences better than 10.0: 375 Number of HSP's gapped: 18254 Number of HSP's successfully gapped: 387 Length of query: 463 Length of database: 100,686,439 Length adjustment: 117 Effective length of query: 346 Effective length of database: 68,593,924 Effective search space: 23733497704 Effective search space used: 23733497704 Neighboring words threshold: 12 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
