>IDE_DROME (P22817) Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin)|
            (Insulinase) (Insulin protease)
          Length = 989

 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 27/91 (29%), Positives = 50/91 (54%), Gaps = 5/91 (5%)
 Frame = -1

Query: 416  EISQGTLKFDRKEAEVAALGELKKEELIEFFDNYVKVGAPEKKILSIQIYGGL----HAS 249
            EI+  T  F+R+EAEVA L ++ K + +++F  ++     E+++LS+ I          S
Sbjct: 883  EIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQTDENATS 942

Query: 248  EYEKIVHDVPPPHSHR-ITDIFSFRRSRPLY 159
            E E +  ++     H+ I+DI +F+  + LY
Sbjct: 943  EAEPV--EITNMERHKPISDIVTFKSCKELY 971

>IDE_RAT (P35559) Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin)|
            (Insulinase) (Insulin protease)
          Length = 1019

 Score = 39.7 bits (91), Expect = 0.003
 Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 10/96 (10%)
 Frame = -1

Query: 416  EISQGTLKFDRKEAEVAALGELKKEELIEFFDNYVKVGAPEKKILSIQIYG--------- 264
            EI      +DR   EVA L  L K+++I+F+   + V AP +  +S+ +           
Sbjct: 910  EIISQQYNYDRDNIEVAYLKTLSKDDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVV 969

Query: 263  GLHASEYEKIVHDVPP-PHSHRITDIFSFRRSRPLY 159
            G   S+ +  + + PP P    I ++  F+R  PL+
Sbjct: 970  GEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLF 1005

>IDE_MOUSE (Q9JHR7) Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin)|
            (Insulinase) (Insulin protease)
          Length = 1019

 Score = 39.3 bits (90), Expect = 0.004
 Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 10/96 (10%)
 Frame = -1

Query: 416  EISQGTLKFDRKEAEVAALGELKKEELIEFFDNYVKVGAPEKKILSIQIYG--------- 264
            EI      +DR   EVA L  L K+++I F+   + V AP +  +S+ +           
Sbjct: 910  EIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLAREMDSCPVV 969

Query: 263  GLHASEYEKIVHDVPP-PHSHRITDIFSFRRSRPLY 159
            G   S+ +  + + PP P    I ++  F+R  PL+
Sbjct: 970  GEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLF 1005

>IDE_HUMAN (P14735) Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin)|
            (Insulinase) (Insulin protease)
          Length = 1018

 Score = 36.6 bits (83), Expect = 0.024
 Identities = 18/49 (36%), Positives = 27/49 (55%)
 Frame = -1

Query: 416  EISQGTLKFDRKEAEVAALGELKKEELIEFFDNYVKVGAPEKKILSIQI 270
            EI      FDR   EVA L  L KE++I+F+   + V AP +  +S+ +
Sbjct: 909  EIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHV 957

>YJU7_YEAST (P39526) Hypothetical 229.9 kDa protein in NUC1-NCE1 intergenic|
           region
          Length = 2014

 Score = 30.4 bits (67), Expect = 1.7
 Identities = 18/61 (29%), Positives = 30/61 (49%)
 Frame = +3

Query: 180 EAEYISYSMRMRGRNIMNNLFVLRGMETTIDLYAKDLLFWCADLDIIIKELYQLFLLKLP 359
           E++YISY + MR      +        T+ +LY K LL W   + ++  +  Q   L++P
Sbjct: 551 ESDYISYELIMRITVFSTSFIKNNTTSTSSNLYFKGLLCWILLIGLMNYKDEQYLKLQIP 610

Query: 360 Q 362
           Q
Sbjct: 611 Q 611

>VATB_CHLCV (Q822J9) V-type ATP synthase beta chain (EC 3.6.3.14) (V-type|
           ATPase subunit B)
          Length = 438

 Score = 29.6 bits (65), Expect = 2.9
 Identities = 15/40 (37%), Positives = 25/40 (62%)
 Frame = -1

Query: 380 EAEVAALGELKKEELIEFFDNYVKVGAPEKKILSIQIYGG 261
           EAE A LGEL + E ++   +Y  V   + K +++Q++GG
Sbjct: 19  EAEGARLGELAEIERVDGRSSYASVLRFDAKKVTLQVFGG 58

>TLK2_MOUSE (O55047) Serine/threonine-protein kinase tousled-like 2 (EC|
           2.7.11.1) (Tousled-like kinase 2)
          Length = 718

 Score = 28.9 bits (63), Expect = 5.0
 Identities = 24/86 (27%), Positives = 36/86 (41%)
 Frame = -1

Query: 413 ISQGTLKFDRKEAEVAALGELKKEELIEFFDNYVKVGAPEKKILSIQIYGGLHASEYEKI 234
           +S+G L  +     + ++G L  +E          V  PEKK  + Q      A  Y+  
Sbjct: 25  VSKGPLNSESSNQSLCSVGSLSDKE----------VETPEKK-QNDQRNRKRKAEPYDTS 73

Query: 233 VHDVPPPHSHRITDIFSFRRSRPLYG 156
                 P  H+I+D F  R  +PLYG
Sbjct: 74  -QGKGTPRGHKISDYFERRAEQPLYG 98

>Y859_METJA (Q58269) Hypothetical protein MJ0859|
          Length = 164

 Score = 28.5 bits (62), Expect = 6.6
 Identities = 16/54 (29%), Positives = 27/54 (50%)
 Frame = -1

Query: 398 LKFDRKEAEVAALGELKKEELIEFFDNYVKVGAPEKKILSIQIYGGLHASEYEK 237
           +KF  K+ E    G++  + + + FDNYV +G   K ++     GG+    Y K
Sbjct: 31  IKFLDKDEEYEGDGKVLYQVIYDDFDNYVLMGTVTKDMIIEYEVGGVRQITYIK 84

>YIF1_YEAST (P53845) Protein YIF1 (YIP1-interacting factor 1)|
          Length = 314

 Score = 28.5 bits (62), Expect = 6.6
 Identities = 24/63 (38%), Positives = 29/63 (46%), Gaps = 6/63 (9%)
 Frame = +3

Query: 225 IMNNLFVLRGMETTIDLYAK---DLLFWCADLDIIIKELYQLFLLKLPQCS---NLCFLS 386
           I N    L+G     DLY K    L F C DL I+   LY L   K+P  S    LC++ 
Sbjct: 167 IWNTQQGLKGSFNPEDLYYKLSSTLAFVCLDLLILKLGLYLLIDSKIPSFSLVELLCYVG 226

Query: 387 IKF 395
            KF
Sbjct: 227 YKF 229

>STE23_YEAST (Q06010) A-factor-processing enzyme (EC 3.4.99.-)|
          Length = 1027

 Score = 28.5 bits (62), Expect = 6.6
 Identities = 10/44 (22%), Positives = 24/44 (54%)
 Frame = -1

Query: 404  GTLKFDRKEAEVAALGELKKEELIEFFDNYVKVGAPEKKILSIQ 273
            G   F  ++ +   +  + K+++I+F++NY+      K IL ++
Sbjct: 923  GDYNFTHRQKKAKLVANITKQQMIDFYENYIMSENASKLILHLK 966

>VATB_CHLMU (Q9PK86) V-type ATP synthase beta chain (EC 3.6.3.14) (V-type|
           ATPase subunit B)
          Length = 438

 Score = 28.5 bits (62), Expect = 6.6
 Identities = 15/40 (37%), Positives = 25/40 (62%)
 Frame = -1

Query: 380 EAEVAALGELKKEELIEFFDNYVKVGAPEKKILSIQIYGG 261
           EAE A+LGEL + E  +   +Y  V   + K +++Q++GG
Sbjct: 19  EAEGASLGELVQIERADGRSSYASVLRFDAKKVTLQVFGG 58

>S6A18_HUMAN (Q96N87) Sodium- and chloride-dependent transporter XTRP2 (Solute|
           carrier family 6 member 18)
          Length = 628

 Score = 28.1 bits (61), Expect = 8.6
 Identities = 10/33 (30%), Positives = 16/33 (48%)
 Frame = -3

Query: 153 IQRWCWSDEAIGQLCFVSYLHSTCIFPKENNVW 55
           + RW   +   G +C V +L +TC   +  N W
Sbjct: 435 LPRWVPKEALTGLVCLVCFLSATCFTLQSGNYW 467

>YN60_YEAST (P42840) Hypothetical 32.3 kDa protein in KRE1-HXT14 intergenic|
           region
          Length = 284

 Score = 28.1 bits (61), Expect = 8.6
 Identities = 21/60 (35%), Positives = 26/60 (43%), Gaps = 1/60 (1%)
 Frame = -1

Query: 287 ILSIQIYGGLHASEYEK-IVHDVPPPHSHRITDIFSFRRSRPLYGSFKGGAGQMKL*DNF 111
           I S + YG    S  EK +  D     SH  TD F  +R   LYG   GGA  + +   F
Sbjct: 111 IYSYRGYGNSEGSPSEKGLKLDADCVISHLSTDSFHSKRKLVLYGRSLGGANALYIASKF 170

>Y110_DEIRA (Q9RY41) UPF0135 protein DR0110|
          Length = 263

 Score = 28.1 bits (61), Expect = 8.6
 Identities = 11/33 (33%), Positives = 22/33 (66%), Gaps = 1/33 (3%)
 Frame = -1

Query: 359 GELKKEELIEFFDNYVKVGA-PEKKILSIQIYG 264
           GE+ ++EL+ +   Y+++GA P+  +  +QI G
Sbjct: 12  GEIGRDELVRWLGEYLRIGAYPDPSLNGLQIQG 44

>HME2_CHICK (Q05917) Homeobox protein engrailed-2 (Gg-En-2)|
          Length = 288

 Score = 28.1 bits (61), Expect = 8.6
 Identities = 13/29 (44%), Positives = 15/29 (51%)
 Frame = -1

Query: 221 PPPHSHRITDIFSFRRSRPLYGSFKGGAG 135
           P PH HRIT+ F     RP +G  K   G
Sbjct: 41  PHPHPHRITNFFIDNILRPEFGRRKEAGG 69


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,807,212
Number of Sequences: 219361
Number of extensions: 1150019
Number of successful extensions: 2709
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 2655
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2708
length of database: 80,573,946
effective HSP length: 100
effective length of database: 58,637,846
effective search space used: 2228238148
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)