>DLL3_HUMAN (Q9NYJ7) Delta-like protein 3 precursor (Drosophila Delta homolog|
           3)
          Length = 618

 Score = 33.9 bits (76), Expect = 0.11
 Identities = 26/105 (24%), Positives = 38/105 (36%), Gaps = 30/105 (28%)
 Frame = -3

Query: 230 CPCCARFYGM---LALIQCLLHSC*NVSICCGAAE---------------YSCKKFYDEC 105
           C C   FYG+   ++ + C    C N  +C G A+                +C+K  D C
Sbjct: 298 CTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRC 357

Query: 104 LLHSC*NVSIC------------CGAAEYSCKKFYDECLLHSC*N 6
            L  C N  +C             G A   C+   D+C   +C N
Sbjct: 358 SLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACAN 402

>DLL3_MOUSE (O88516) Delta-like protein 3 precursor (Drosophila Delta homolog|
           3) (M-Delta-3)
          Length = 592

 Score = 32.0 bits (71), Expect = 0.43
 Identities = 25/105 (23%), Positives = 37/105 (35%), Gaps = 30/105 (28%)
 Frame = -3

Query: 230 CPCCARFYGM---LALIQCLLHSC*NVSICCGAAE---------------YSCKKFYDEC 105
           C C   FYG+   ++ + C    C N  +C G  +                +C+K  D C
Sbjct: 296 CACPRGFYGLRCEVSGVTCADGPCFNGGLCVGGEDPDSAYVCHCPPGFQGSNCEKRVDRC 355

Query: 104 LLHSC*NVSIC------------CGAAEYSCKKFYDECLLHSC*N 6
            L  C N  +C             G A   C+   D+C   +C N
Sbjct: 356 SLQPCQNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACAN 400

>DLLA_BRARE (Q6DI48) Delta-like protein A precursor (DeltaA protein)|
          Length = 772

 Score = 31.6 bits (70), Expect = 0.56
 Identities = 26/103 (25%), Positives = 36/103 (34%), Gaps = 28/103 (27%)
 Frame = -3

Query: 230 CPCCARFYGM---LALIQCLLHSC*NVSICC-------------GAAEYSCKKFYDECLL 99
           C C   FYG    L+ + C    C N   C              G A ++C+K  D C  
Sbjct: 354 CTCPPGFYGKNCELSAMTCADGPCFNGGRCADNPDGGYFCQCPTGYAGFNCEKKIDHCSS 413

Query: 98  HSC*NVSICC------------GAAEYSCKKFYDECLLHSC*N 6
             C N + C             G    +C +  DEC ++ C N
Sbjct: 414 SPCSNGARCVDLVNSYLCQCPDGFTGMNCDRAGDECSMYPCQN 456

>NOTCH_DROME (P07207) Neurogenic locus Notch protein precursor|
          Length = 2703

 Score = 31.2 bits (69), Expect = 0.73
 Identities = 12/30 (40%), Positives = 20/30 (66%), Gaps = 1/30 (3%)
 Frame = -3

Query: 131 SCKKFYDECLLHSC*NVSICC-GAAEYSCK 45
           +C++ YD+CL H C N   C  G ++Y+C+
Sbjct: 289 NCEQNYDDCLGHLCQNGGTCIDGISDYTCR 318

>SLIT1_RAT (O88279) Slit homolog 1 protein precursor (Slit-1) (Multiple|
            epidermal growth factor-like domains 4)
          Length = 1531

 Score = 30.4 bits (67), Expect = 1.2
 Identities = 26/104 (25%), Positives = 39/104 (37%), Gaps = 29/104 (27%)
 Frame = -3

Query: 230  CPCCARFYGMLALIQ---CLLHSC*NVSICC-GAAEYSCK-----------KFYDECL-- 102
            C C + F G+   +    C+ H C N  +C  G   Y+C+           +  D C   
Sbjct: 991  CSCPSGFEGLTCGMNTDDCVKHDCVNGGVCVDGIGNYTCQCPLQYTGRACEQLVDFCSPD 1050

Query: 101  LHSC*NVSICCGAAEY------------SCKKFYDECLLHSC*N 6
            L+ C + + C G  E             +C K  D+C  H C N
Sbjct: 1051 LNPCQHEAQCVGTPEGPRCECVPGYTGDNCSKNQDDCKDHQCQN 1094

>PALA_SCHPO (Q09807) pH-response regulator protein palA/rim20|
          Length = 701

 Score = 30.4 bits (67), Expect = 1.2
 Identities = 13/53 (24%), Positives = 35/53 (66%), Gaps = 6/53 (11%)
 Frame = +2

Query: 47  YKNIRRLHNKLIHSSRNAKDTRHRIFYKNIRRLHNKL------IHSSKNAKDT 187
           Y++  +  +++I+S +++++ + + FY ++ +LH ++      + +S+NAKDT
Sbjct: 439 YRHCCQALDEIINSVKSSQNMKEKGFYSDVIKLHEEVSLLKVNVENSQNAKDT 491



 Score = 27.7 bits (60), Expect = 8.0
 Identities = 12/42 (28%), Positives = 28/42 (66%), Gaps = 6/42 (14%)
 Frame = +2

Query: 2   IHSSRNAKDTRHRIFYKNIRRLHNKL------IHSSRNAKDT 109
           I+S +++++ + + FY ++ +LH ++      + +S+NAKDT
Sbjct: 450 INSVKSSQNMKEKGFYSDVIKLHEEVSLLKVNVENSQNAKDT 491

>DLLD_BRARE (Q8UWJ4) Delta-like protein D precursor (DeltaD protein) (After|
           eight protein)
          Length = 717

 Score = 30.4 bits (67), Expect = 1.2
 Identities = 26/103 (25%), Positives = 35/103 (33%), Gaps = 28/103 (27%)
 Frame = -3

Query: 230 CPCCARFYGM---LALIQCLLHSC*NVSICC-------------GAAEYSCKKFYDECLL 99
           C C   FYG    L+ + C    C N   C              G A ++C+K  D C  
Sbjct: 350 CTCPPGFYGRNCELSAMTCADGPCFNGGHCADNPEGGYFCQCPMGYAGFNCEKKIDHCSS 409

Query: 98  HSC*NVSICC------------GAAEYSCKKFYDECLLHSC*N 6
           + C N + C             G     C+   DEC  + C N
Sbjct: 410 NPCSNDAQCLDLVDSYLCQCPEGFTGTHCEDNIDECATYPCQN 452

>NOTC2_RAT (Q9QW30) Neurogenic locus notch homolog protein 2 precursor (Notch|
           2) [Contains: Notch 2 extracellular truncation; Notch 2
           intracellular domain]
          Length = 2471

 Score = 30.4 bits (67), Expect = 1.2
 Identities = 24/98 (24%), Positives = 35/98 (35%), Gaps = 28/98 (28%)
 Frame = -3

Query: 230 CPCCARFYGMLA---LIQCLLHSC*NVSICCGAAEYS-------------CKKFYDECLL 99
           C C  RF G       + C    C N   C    +++             C++  D+C  
Sbjct: 207 CQCPQRFTGQHCDSPYVPCAPSPCVNGGTCRQTGDFTSECHCLPGFEGSNCERNIDDCPN 266

Query: 98  HSC*NVSICC-GAAEYSCK-----------KFYDECLL 21
           H C N  +C  G   Y+C+           +  DECLL
Sbjct: 267 HKCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLL 304

>Y244_BUCAP (Q8K9R6) UPF0125 protein BUsg244|
          Length = 95

 Score = 29.3 bits (64), Expect = 2.8
 Identities = 12/31 (38%), Positives = 19/31 (61%)
 Frame = +2

Query: 44  FYKNIRRLHNKLIHSSRNAKDTRHRIFYKNI 136
           FYKN   ++NKL+H + N K+      Y+N+
Sbjct: 47  FYKNNVGIYNKLVHLNENVKNGDRIEIYRNL 77

>DLL3_RAT (O88671) Delta-like protein 3 precursor (Drosophila Delta homolog|
           3)
          Length = 589

 Score = 29.3 bits (64), Expect = 2.8
 Identities = 24/105 (22%), Positives = 36/105 (34%), Gaps = 30/105 (28%)
 Frame = -3

Query: 230 CPCCARFYGM---LALIQCLLHSC*NVSICCGAAE---------------YSCKKFYDEC 105
           C C   FYG    ++ + C    C N  +C G  +                +C++  D C
Sbjct: 300 CACPRGFYGPRCEVSGVTCADGPCFNGGLCVGGEDPDSAYVCHCPPAFQGSNCERRVDRC 359

Query: 104 LLHSC*NVSIC------------CGAAEYSCKKFYDECLLHSC*N 6
            L  C N  +C             G A   C+   D+C   +C N
Sbjct: 360 SLQPCQNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACAN 404

>GSTP_DIRIM (P46426) Glutathione S-transferase (EC 2.5.1.18) (GST class-pi)|
          Length = 208

 Score = 29.3 bits (64), Expect = 2.8
 Identities = 15/45 (33%), Positives = 24/45 (53%)
 Frame = +2

Query: 2   IHSSRNAKDTRHRIFYKNIRRLHNKLIHSSRNAKDTRHRIFYKNI 136
           ++   NA+ +   +FY+ IR LH+K       A +T+   F KNI
Sbjct: 76  LNGENNAETSYVDMFYEGIRDLHSKYTRMIYEAYETQKDPFIKNI 120

>HELS_METJA (Q58524) Putative ski2-type helicase (EC 3.6.1.-) [Contains:|
           Endonuclease PI-MjaHel (EC 3.1.-.-) (Mja Hel intein)
           (Mja Pep3 intein)]
          Length = 1195

 Score = 28.9 bits (63), Expect = 3.6
 Identities = 14/40 (35%), Positives = 22/40 (55%)
 Frame = +2

Query: 65  LHNKLIHSSRNAKDTRHRIFYKNIRRLHNKLIHSSKNAKD 184
           LH K     R +K   H I+ K +R++ NKL   +K+ K+
Sbjct: 490 LHKKYFLKCRISKGVAHYIYSKKLRKIFNKLNMLTKDNKN 529

>CRUM1_MOUSE (Q8VHS2) Crumbs homolog 1 precursor|
          Length = 1405

 Score = 28.5 bits (62), Expect = 4.7
 Identities = 17/46 (36%), Positives = 22/46 (47%), Gaps = 2/46 (4%)
 Frame = -3

Query: 161 VSICC-GAAEYSCKKFYDECLLHSC*NVSICCG-AAEYSCKKFYDE 30
           V IC  G     C++  DECLLH C N   C      Y+C   +D+
Sbjct: 381 VCICQPGFTGIHCEEDVDECLLHPCLNGGTCENLPGNYACHCPFDD 426

>HIS8_BLOFL (Q7VQW9) Histidinol-phosphate aminotransferase (EC 2.6.1.9)|
           (Imidazole acetol-phosphate transaminase)
          Length = 356

 Score = 28.5 bits (62), Expect = 4.7
 Identities = 14/52 (26%), Positives = 26/52 (50%)
 Frame = -1

Query: 181 FCILARMYQFVVEPPNILVKNSMTSVFCIPARMYQFVVEPPNILVKNSMTSV 26
           FC  A + Q + E PN+++  +++  F +      F +  P I+  N +T V
Sbjct: 187 FCRHASLIQLLTEYPNLIILRTLSKAFALAGLRCGFTLANPKII--NLLTKV 236

>CUBN_CANFA (Q9TU53) Cubilin precursor|
          Length = 3620

 Score = 28.5 bits (62), Expect = 4.7
 Identities = 24/83 (28%), Positives = 31/83 (37%), Gaps = 11/83 (13%)
 Frame = -3

Query: 221 CARFYGMLALIQCLLHSC*NVSICCGAAEYSCKKFYDECLLHSC*NVS--------IC-- 72
           C+   G L L  CL     N     G     C +  D CL H C N          +C  
Sbjct: 363 CSSVLGSLPLCTCLPGYTGN-----GYGPNGCAQLSDTCLSHPCLNGQCIETVSGYLCKC 417

Query: 71  -CGAAEYSCKKFYDECLLHSC*N 6
             G A  +C +  +ECL + C N
Sbjct: 418 ESGWAGINCTENINECLSNPCFN 440

>PRP4B_HUMAN (Q13523) Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1)|
           (PRP4 pre-mRNA-processing factor 4 homolog) (PRP4
           kinase)
          Length = 1007

 Score = 28.5 bits (62), Expect = 4.7
 Identities = 15/49 (30%), Positives = 25/49 (51%)
 Frame = +2

Query: 23  KDTRHRIFYKNIRRLHNKLIHSSRNAKDTRHRIFYKNIRRLHNKLIHSS 169
           K +RH+      R  H K  HSS   KD +H+  +K+ +    ++I +S
Sbjct: 39  KHSRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKKHKRKEVIDAS 87

>NOTC1_HUMAN (P46531) Neurogenic locus notch homolog protein 1 precursor (Notch 1)|
            (hN1) (Translocation-associated notch protein TAN-1)
            [Contains: Notch 1 extracellular truncation; Notch 1
            intracellular domain]
          Length = 2556

 Score = 28.1 bits (61), Expect = 6.1
 Identities = 18/53 (33%), Positives = 21/53 (39%), Gaps = 12/53 (22%)
 Frame = -3

Query: 128  CKKFYDECLLHSC*NVSICCG-AAEYSCK-----------KFYDECLLHSC*N 6
            C+   DEC    C N + C      YSCK           +  DECL H C N
Sbjct: 1143 CEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQN 1195

>NOTC2_HUMAN (Q04721) Neurogenic locus notch homolog protein 2 precursor (Notch|
           2) (hN2) [Contains: Notch 2 extracellular truncation;
           Notch 2 intracellular domain]
          Length = 2471

 Score = 28.1 bits (61), Expect = 6.1
 Identities = 23/98 (23%), Positives = 34/98 (34%), Gaps = 28/98 (28%)
 Frame = -3

Query: 230 CPCCARFYGMLA---LIQCLLHSC*NVSICCGAAEYS-------------CKKFYDECLL 99
           C C   F G       + C    C N   C    +++             C++  D+C  
Sbjct: 207 CQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPN 266

Query: 98  HSC*NVSICC-GAAEYSCK-----------KFYDECLL 21
           H C N  +C  G   Y+C+           +  DECLL
Sbjct: 267 HRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLL 304

>PRP4B_MOUSE (Q61136) Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1)|
           (PRP4 pre-mRNA-processing factor 4 homolog) (Pre-mRNA
           protein kinase)
          Length = 1007

 Score = 28.1 bits (61), Expect = 6.1
 Identities = 20/76 (26%), Positives = 33/76 (43%)
 Frame = +2

Query: 23  KDTRHRIFYKNIRRLHNKLIHSSRNAKDTRHRIFYKNIRRLHNKLIHSSKNAKDTG*GLA 202
           K +RH+      R  H K  HSS   +D +H+  +K+ +    ++I +S        GL+
Sbjct: 40  KHSRHKKKKHKHRSKHKKHKHSSEEDRDKKHKHKHKHKKHKRKEVIEASDKE-----GLS 94

Query: 203 SHKTWHNKDIKASSDL 250
             K     D+    DL
Sbjct: 95  PAKRTKLDDLALLEDL 110

>NOTC2_MOUSE (O35516) Neurogenic locus notch homolog protein 2 precursor (Notch|
           2) (Motch B) [Contains: Notch 2 extracellular
           truncation; Notch 2 intracellular domain]
          Length = 2470

 Score = 27.7 bits (60), Expect = 8.0
 Identities = 15/49 (30%), Positives = 23/49 (46%), Gaps = 12/49 (24%)
 Frame = -3

Query: 131 SCKKFYDECLLHSC*NVSICC-GAAEYSCK-----------KFYDECLL 21
           +C++  D+C  H C N  +C  G   Y+C+           +  DECLL
Sbjct: 254 TCERNIDDCPNHKCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLL 302

>NOTCH_XENLA (P21783) Neurogenic locus notch protein homolog precursor (XOTCH|
            protein)
          Length = 2524

 Score = 27.7 bits (60), Expect = 8.0
 Identities = 19/68 (27%), Positives = 27/68 (39%), Gaps = 15/68 (22%)
 Frame = -3

Query: 164  NVSICCGAAEYS---CKKFYDECLLHSC*NVSIC------------CGAAEYSCKKFYDE 30
            N   C   A Y+   C++  DEC  + C N + C             G    +C +  +E
Sbjct: 1126 NTHFCRCQAGYTGSYCEEQVDECSPNPCQNGATCTDYLGGYSCECVAGYHGVNCSEEINE 1185

Query: 29   CLLHSC*N 6
            CL H C N
Sbjct: 1186 CLSHPCQN 1193


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,129,142
Number of Sequences: 219361
Number of extensions: 701110
Number of successful extensions: 1915
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 1449
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1892
length of database: 80,573,946
effective HSP length: 64
effective length of database: 66,534,842
effective search space used: 1596836208
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)