>TOP1_ARATH (P30181) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
          Length = 916

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 39/47 (82%), Positives = 44/47 (93%)
 Frame = -3

Query: 460  TSKINYLDPRITVAWCKTHEVPIEKIFSKTILAKFGWAMDVEPDFRF 320
            TSKINYLDPRITVAWCK HEVPIEKIF+K++L KF WAMDVEP++RF
Sbjct: 867  TSKINYLDPRITVAWCKRHEVPIEKIFTKSLLEKFAWAMDVEPEYRF 913

>TOP1_DAUCA (P93119) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
          Length = 790

 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 38/47 (80%), Positives = 42/47 (89%)
 Frame = -3

Query: 460 TSKINYLDPRITVAWCKTHEVPIEKIFSKTILAKFGWAMDVEPDFRF 320
           TSKINYLDPRITVAWCK H+VPIEKIF+K++LAKF WAMDV   FRF
Sbjct: 744 TSKINYLDPRITVAWCKRHDVPIEKIFNKSLLAKFAWAMDVVLIFRF 790

>TOP1_DROME (P30189) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
          Length = 972

 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 31/48 (64%), Positives = 40/48 (83%), Gaps = 1/48 (2%)
 Frame = -3

Query: 460  TSKINYLDPRITVAWCKTHEVPIEKIFSKTILAKFGWAMDV-EPDFRF 320
            TSK+NYLDPRI+VAWCK H+VPIEKIF+KT   KF WA+ + + ++RF
Sbjct: 925  TSKLNYLDPRISVAWCKKHDVPIEKIFNKTQRTKFLWAVHMADENYRF 972

>TOP1_RAT (Q9WUL0) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
          Length = 767

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 31/48 (64%), Positives = 38/48 (79%), Gaps = 1/48 (2%)
 Frame = -3

Query: 460 TSKINYLDPRITVAWCKTHEVPIEKIFSKTILAKFGWAMDV-EPDFRF 320
           TSK+NYLDPRITVAWCK   VPIEKI++KT   KF WA+D+ + D+ F
Sbjct: 720 TSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF 767

>TOP1_MOUSE (Q04750) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
          Length = 767

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 31/48 (64%), Positives = 38/48 (79%), Gaps = 1/48 (2%)
 Frame = -3

Query: 460 TSKINYLDPRITVAWCKTHEVPIEKIFSKTILAKFGWAMDV-EPDFRF 320
           TSK+NYLDPRITVAWCK   VPIEKI++KT   KF WA+D+ + D+ F
Sbjct: 720 TSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF 767

>TOP1_CRIGR (Q07050) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
          Length = 767

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 31/48 (64%), Positives = 38/48 (79%), Gaps = 1/48 (2%)
 Frame = -3

Query: 460 TSKINYLDPRITVAWCKTHEVPIEKIFSKTILAKFGWAMDV-EPDFRF 320
           TSK+NYLDPRITVAWCK   VPIEKI++KT   KF WA+D+ + D+ F
Sbjct: 720 TSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF 767

>TOP1_CERAE (Q7YR26) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
          Length = 767

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 31/48 (64%), Positives = 38/48 (79%), Gaps = 1/48 (2%)
 Frame = -3

Query: 460 TSKINYLDPRITVAWCKTHEVPIEKIFSKTILAKFGWAMDV-EPDFRF 320
           TSK+NYLDPRITVAWCK   VPIEKI++KT   KF WA+D+ + D+ F
Sbjct: 720 TSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF 767

>TOP1_HUMAN (P11387) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
          Length = 765

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 31/48 (64%), Positives = 38/48 (79%), Gaps = 1/48 (2%)
 Frame = -3

Query: 460 TSKINYLDPRITVAWCKTHEVPIEKIFSKTILAKFGWAMDV-EPDFRF 320
           TSK+NYLDPRITVAWCK   VPIEKI++KT   KF WA+D+ + D+ F
Sbjct: 718 TSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF 765

>TOP1_SCHPO (P07799) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
          Length = 814

 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 28/47 (59%), Positives = 37/47 (78%)
 Frame = -3

Query: 460 TSKINYLDPRITVAWCKTHEVPIEKIFSKTILAKFGWAMDVEPDFRF 320
           TSKINY+DPR+T ++ K  +VPIEK+FSKTI  KF WA D  PD+++
Sbjct: 768 TSKINYIDPRLTYSFSKREDVPIEKLFSKTIRDKFNWAADTPPDWKW 814

>TOP1_YEAST (P04786) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
           (Maintenance of killer protein 1)
          Length = 769

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 28/48 (58%), Positives = 41/48 (85%), Gaps = 1/48 (2%)
 Frame = -3

Query: 460 TSKINYLDPRITVAWCKTHEVPIEKIFSKTILAKFGWAMD-VEPDFRF 320
           TSKINY+DPR++V +CK ++VPIEKIF+KT+  KF WA++ V+ ++RF
Sbjct: 722 TSKINYIDPRLSVVFCKKYDVPIEKIFTKTLREKFKWAIESVDENWRF 769

>TOP1M_HUMAN (Q969P6) DNA topoisomerase I, mitochondrial precursor (EC 5.99.1.2)|
           (TOP1mt)
          Length = 601

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 28/48 (58%), Positives = 36/48 (75%), Gaps = 1/48 (2%)
 Frame = -3

Query: 460 TSKINYLDPRITVAWCKTHEVPIEKIFSKTILAKFGWAMDVE-PDFRF 320
           TSK+NYLDPRI++AWCK   VP+EKI+SKT   +F WA+ +   DF F
Sbjct: 554 TSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFAWALAMAGEDFEF 601

>TOP1_XENLA (P41512) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
          Length = 829

 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 23/30 (76%), Positives = 28/30 (93%)
 Frame = -3

Query: 460 TSKINYLDPRITVAWCKTHEVPIEKIFSKT 371
           TSK+NYLDPRI+VAWCK + VPIEKI++KT
Sbjct: 774 TSKLNYLDPRISVAWCKKYGVPIEKIYNKT 803

>TOP1_CANAL (Q00313) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
          Length = 778

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 24/48 (50%), Positives = 37/48 (77%), Gaps = 1/48 (2%)
 Frame = -3

Query: 460 TSKINYLDPRITVAWCKTHEVPIEKIFSKTILAKFGWAMD-VEPDFRF 320
           TSK+NY+DPR+ V + K  +VPIEK+F+KT+  KF WA++  + ++RF
Sbjct: 731 TSKMNYIDPRLIVMFSKKFDVPIEKLFTKTLREKFIWAIESADENWRF 778

>TOP1_USTMA (P41511) DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)|
          Length = 1019

 Score = 34.7 bits (78), Expect = 0.12
 Identities = 13/17 (76%), Positives = 16/17 (94%)
 Frame = -3

Query: 460 TSKINYLDPRITVAWCK 410
           TSK+NY+DPRIT+AW K
Sbjct: 817 TSKLNYIDPRITLAWLK 833

>CASP2_HUMAN (P42575) Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1|
           protease) (ICH-1L/1S) [Contains: Caspase-2 subunit p18;
           Caspase-2 subunit p13; Caspase-2 subunit p12]
          Length = 452

 Score = 28.9 bits (63), Expect = 6.7
 Identities = 22/69 (31%), Positives = 29/69 (42%)
 Frame = +2

Query: 254 EGLEAESNLPRGHWLIQNPILLESEIRLDIHCPSKLCKNRLAENLLNRDFMGFAPCYRNS 433
           +G  A  N  RG W I+    + SE   D+H    L K     N L +D  G+AP     
Sbjct: 372 KGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVK----VNALIKDREGYAPGTEFH 427

Query: 434 RIKVVDL*C 460
           R K +   C
Sbjct: 428 RCKEMSEYC 436


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,444,228
Number of Sequences: 219361
Number of extensions: 1416288
Number of successful extensions: 3295
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 3255
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3294
length of database: 80,573,946
effective HSP length: 102
effective length of database: 58,199,124
effective search space used: 2968155324
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)