>CN12L_MOUSE (Q8BFV2) CSN12-like protein|
          Length = 399

 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 38/89 (42%), Positives = 61/89 (68%), Gaps = 1/89 (1%)
 Frame = -3

Query: 483 LEKLELQVYRRLVKKIHIIQREKEPSKAHQIKLEVLVKTLQWLGIT-MDVDEVECIMACL 307
           LEKL++  YR L KK++++       K HQ+ L+  +  L+++ +  +D+DEV+CI+A L
Sbjct: 314 LEKLKIITYRNLFKKVYLLL------KTHQLSLDAFLVALKFMHVEDVDIDEVQCILANL 367

Query: 306 IYKNLIKGYFAHKSKVLVLSKQDPFPKLN 220
           IY   IKGY +H+ + LV+SKQ+PFP L+
Sbjct: 368 IYMGHIKGYISHQHQKLVVSKQNPFPPLS 396

>CN12L_HUMAN (Q5JVF3) CSN12-like protein|
          Length = 399

 Score = 75.9 bits (185), Expect = 5e-14
 Identities = 37/89 (41%), Positives = 61/89 (68%), Gaps = 1/89 (1%)
 Frame = -3

Query: 483 LEKLELQVYRRLVKKIHIIQREKEPSKAHQIKLEVLVKTLQWLGIT-MDVDEVECIMACL 307
           LEKL++  YR L KK++++       K HQ+ L+  +  L+++ +  +D+DEV+CI+A L
Sbjct: 314 LEKLKIITYRNLFKKVYLLL------KTHQLSLDAFLVALKFMQVEDVDIDEVQCILANL 367

Query: 306 IYKNLIKGYFAHKSKVLVLSKQDPFPKLN 220
           IY   +KGY +H+ + LV+SKQ+PFP L+
Sbjct: 368 IYMGHVKGYISHQHQKLVVSKQNPFPPLS 396

>CN12L_XENLA (Q5FWP8) CSN12-like protein|
          Length = 399

 Score = 75.1 bits (183), Expect = 9e-14
 Identities = 38/89 (42%), Positives = 61/89 (68%), Gaps = 1/89 (1%)
 Frame = -3

Query: 483 LEKLELQVYRRLVKKIHIIQREKEPSKAHQIKLEVLVKTLQWLGI-TMDVDEVECIMACL 307
           LEKL++  YR L KK++++       K HQ+ L+  +  L+++ +  +D+DEV+CI+A L
Sbjct: 314 LEKLKIISYRNLFKKVYLLL------KTHQLSLDAFLVALKFMEVGDVDIDEVQCIIANL 367

Query: 306 IYKNLIKGYFAHKSKVLVLSKQDPFPKLN 220
           IY   IKGY +H+ + LV+SKQ+PFP L+
Sbjct: 368 IYMGHIKGYISHQHQKLVVSKQNPFPPLS 396

>CN12L_BRARE (Q5U3P0) CSN12-like protein|
          Length = 399

 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 39/89 (43%), Positives = 58/89 (65%), Gaps = 1/89 (1%)
 Frame = -3

Query: 483 LEKLELQVYRRLVKKIHIIQREKEPSKAHQIKLEVLVKTLQWLGIT-MDVDEVECIMACL 307
           LEKL++  YR L KK++ + R       HQ+ L   + +LQ   +  +D+DEV+CI+A L
Sbjct: 314 LEKLKIITYRNLFKKVYHLLR------THQLPLAAFLVSLQMTKVEDVDIDEVQCILANL 367

Query: 306 IYKNLIKGYFAHKSKVLVLSKQDPFPKLN 220
           IY   IKGY +H+ + LV+SKQ+PFP L+
Sbjct: 368 IYMGHIKGYISHQHQKLVVSKQNPFPPLS 396

>CN12L_DROME (Q9VTL1) CSN12-like protein|
          Length = 395

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 37/89 (41%), Positives = 57/89 (64%), Gaps = 1/89 (1%)
 Frame = -3

Query: 483 LEKLELQVYRRLVKKIHIIQREKEPSKAHQIKLEVLVKTLQWLGIT-MDVDEVECIMACL 307
           +EKL+  VYR L KK+ +I+      K+HQ+ +   +  L ++G+T + +DE  CI+A L
Sbjct: 312 VEKLKFLVYRNLFKKVFVIR------KSHQLDMGDFLSALHFVGLTDVSLDETHCIVANL 365

Query: 306 IYKNLIKGYFAHKSKVLVLSKQDPFPKLN 220
           IY   IKGY +H    LV+SKQ+PFP ++
Sbjct: 366 IYDGKIKGYISHAHNKLVVSKQNPFPSVS 394

>CN12L_CAEEL (Q95QU0) CSN12-like protein|
          Length = 413

 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 37/90 (41%), Positives = 55/90 (61%), Gaps = 1/90 (1%)
 Frame = -3

Query: 483 LEKLELQVYRRLVKKIHIIQREKEPSKAHQIKLEVLVKTLQWLGIT-MDVDEVECIMACL 307
           LEKL +  +R L KK+  I          QI L+     L+++G+T +D+DE+ECI+A L
Sbjct: 326 LEKLRMITFRTLFKKVSQIVGTA------QIPLDAFQTALRFVGVTDVDMDELECIIANL 379

Query: 306 IYKNLIKGYFAHKSKVLVLSKQDPFPKLNG 217
           I    IKGY +H+ + LV+SK + FP L+G
Sbjct: 380 IASKKIKGYLSHQHQKLVISKMNAFPTLSG 409

>CN12L_CAEBR (Q60YJ7) CSN12-like protein|
          Length = 413

 Score = 62.0 bits (149), Expect = 8e-10
 Identities = 36/89 (40%), Positives = 55/89 (61%), Gaps = 1/89 (1%)
 Frame = -3

Query: 483 LEKLELQVYRRLVKKIHIIQREKEPSKAHQIKLEVLVKTLQWLGIT-MDVDEVECIMACL 307
           LEKL    YR L KK+  +  +       QI L+     L+++G+T +D+DE+ECI+A L
Sbjct: 326 LEKLRTITYRNLFKKVSQMVGKV------QIPLDAFQAALRFVGVTDVDMDELECIIANL 379

Query: 306 IYKNLIKGYFAHKSKVLVLSKQDPFPKLN 220
           I +  +KGY AH+ + LV+SK + FP L+
Sbjct: 380 IAEKKVKGYLAHQHQKLVISKTNAFPTLS 408

>CSN12_CRYNE (Q5KAS8) COP9 signalosome complex subunit 12|
          Length = 403

 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 24/62 (38%), Positives = 44/62 (70%)
 Frame = -3

Query: 405 KAHQIKLEVLVKTLQWLGITMDVDEVECIMACLIYKNLIKGYFAHKSKVLVLSKQDPFPK 226
           K+ ++ +E     L+  G+ ++ DEVEC++A +IY+  +KGY +H+ K++VL K +PFPK
Sbjct: 338 KSTRVPIETFRLALKLHGVDVESDEVECMVANMIYRGYLKGYISHEKKMVVLGKTNPFPK 397

Query: 225 LN 220
           ++
Sbjct: 398 MS 399

>CSN12_DEBHA (Q6BGR7) COP9 signalosome complex subunit 12|
          Length = 438

 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 10/99 (10%)
 Frame = -3

Query: 480 EKLELQVYRRLVKK-IHIIQREKEPSKAHQIKLEVLVKTLQWLG---------ITMDVDE 331
           E ++   Y +LVKK + II      +K+H + L  +   L++              ++D 
Sbjct: 340 EMMKSLCYLKLVKKTVSIIHSLNSETKSHIVPLSAIQLALEFSTNDSYKESDKFAYNLDA 399

Query: 330 VECIMACLIYKNLIKGYFAHKSKVLVLSKQDPFPKLNGK 214
           VECI+A LI    IKGY +H ++ +VLSK + FP L  K
Sbjct: 400 VECILANLISSGKIKGYLSHANRCIVLSKANAFPSLEYK 438

>CSN12_GIBZE (Q4IMN9) COP9 signalosome complex subunit 12|
          Length = 502

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 31/84 (36%), Positives = 46/84 (54%), Gaps = 8/84 (9%)
 Frame = -3

Query: 456 RRLVKKIHI---IQREKEPSKAHQIKLEVLVKTLQWL-----GITMDVDEVECIMACLIY 301
           R L++K+ I       KE   A   +  + V   Q       G  +D DEVEC++A +IY
Sbjct: 368 RNLLRKVFIAGGFDEAKEADAAPVRRTRIPVAEFQAAISMGSGHLVDPDEVECMLANMIY 427

Query: 300 KNLIKGYFAHKSKVLVLSKQDPFP 229
           K+L+KGY A +  ++VLSK+  FP
Sbjct: 428 KDLMKGYIARERGIVVLSKKGAFP 451

>CSN12_USTMA (Q4P8T5) COP9 signalosome complex subunit 12|
          Length = 454

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 22/39 (56%), Positives = 28/39 (71%)
 Frame = -3

Query: 339 VDEVECIMACLIYKNLIKGYFAHKSKVLVLSKQDPFPKL 223
           + E+E I+A LIYK  +KGY AH+  VLVLS +D FP L
Sbjct: 408 IKELEWILATLIYKGYVKGYIAHERGVLVLSAKDAFPAL 446

>CSN12_KLULA (Q6CPB1) COP9 signalosome complex subunit 12|
          Length = 424

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 24/45 (53%), Positives = 33/45 (73%)
 Frame = -3

Query: 342 DVDEVECIMACLIYKNLIKGYFAHKSKVLVLSKQDPFPKLNGKPV 208
           ++DE+ECI+A LI KN IKGY +H  +V++ SK  PFP L  KP+
Sbjct: 380 ELDELECILATLISKNYIKGYLSHSHRVMMTSK-TPFPGL-AKPL 422

>CSN12_ASHGO (Q75BU2) COP9 signalosome complex subunit 12|
          Length = 412

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 18/39 (46%), Positives = 30/39 (76%)
 Frame = -3

Query: 339 VDEVECIMACLIYKNLIKGYFAHKSKVLVLSKQDPFPKL 223
           +D  EC++A LI +  +KGY +H ++VLV+S+ +PFP+L
Sbjct: 367 LDHTECLLANLIARGYVKGYLSHGNRVLVVSRTEPFPRL 405

>CSN12_ASPFU (Q4WJX0) COP9 signalosome complex subunit 12|
          Length = 455

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 19/34 (55%), Positives = 28/34 (82%)
 Frame = -3

Query: 345 MDVDEVECIMACLIYKNLIKGYFAHKSKVLVLSK 244
           +D+DEVEC+++ LIYK L+KGY A +  ++VLSK
Sbjct: 412 VDIDEVECLLSNLIYKGLMKGYIARERGMVVLSK 445

>CSN12_CANGA (Q6FJ48) COP9 signalosome complex subunit 12|
          Length = 449

 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 19/37 (51%), Positives = 26/37 (70%)
 Frame = -3

Query: 339 VDEVECIMACLIYKNLIKGYFAHKSKVLVLSKQDPFP 229
           +DE+EC +A LI    IKGY +H  + +VLSK +PFP
Sbjct: 410 LDELECRIANLIANGRIKGYLSHSQRCMVLSKTEPFP 446

>CSN12_NEUCR (Q7SD63) COP9 signalosome complex subunit 12|
          Length = 461

 Score = 42.0 bits (97), Expect = 9e-04
 Identities = 21/48 (43%), Positives = 29/48 (60%), Gaps = 9/48 (18%)
 Frame = -3

Query: 345 MDVDEVECIMACLIYK---------NLIKGYFAHKSKVLVLSKQDPFP 229
           ++ DE+EC+MA +IYK         NL+KGY A +   +VLSK   FP
Sbjct: 410 LETDEIECLMANMIYKLVTNQSGIKNLMKGYIARERGFVVLSKSGAFP 457

>CSN12_SCHPO (O13873) COP9 signalosome complex subunit 12|
          Length = 423

 Score = 41.2 bits (95), Expect = 0.001
 Identities = 26/77 (33%), Positives = 40/77 (51%)
 Frame = -3

Query: 456 RRLVKKIHIIQREKEPSKAHQIKLEVLVKTLQWLGITMDVDEVECIMACLIYKNLIKGYF 277
           R L +K  II       K+ ++ + V    LQ  G  +    VE I+A +I K  ++GY 
Sbjct: 348 RNLFRKTWIIC-----GKSTRLPVSVFQIALQVAGTDLPKLHVEAILANMISKGYMRGYI 402

Query: 276 AHKSKVLVLSKQDPFPK 226
           +   + +VLS +DPFPK
Sbjct: 403 SRNFETVVLSAKDPFPK 419

>CSN12_YARLI (Q6C1L4) COP9 signalosome complex subunit 12|
          Length = 396

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 21/88 (23%), Positives = 48/88 (54%)
 Frame = -3

Query: 483 LEKLELQVYRRLVKKIHIIQREKEPSKAHQIKLEVLVKTLQWLGITMDVDEVECIMACLI 304
           +EK+ + V+ +L  ++ + +      KA +I ++      + +G+ +  D +E  ++ +I
Sbjct: 311 VEKMRVFVFEKLFYRVFLAK-----DKATRITIDDYQAAAKLVGVDVSPDFLEATVSNMI 365

Query: 303 YKNLIKGYFAHKSKVLVLSKQDPFPKLN 220
           Y + +KGY + +   +VL  +  FPKL+
Sbjct: 366 YHDRLKGYISRERHTVVLRAEGAFPKLD 393

>CSN12_YEAST (P47130) Cop9 signalosome complex subunit 12|
          Length = 423

 Score = 38.5 bits (88), Expect = 0.010
 Identities = 14/37 (37%), Positives = 25/37 (67%)
 Frame = -3

Query: 339 VDEVECIMACLIYKNLIKGYFAHKSKVLVLSKQDPFP 229
           +D +EC +A  I   L++ Y +H ++ +V SK++PFP
Sbjct: 384 LDALECRLASAIASGLLRAYLSHSNRCIVFSKKEPFP 420

>GLMU_HELPY (O25393) Bifunctional protein glmU [Includes:|
           UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23)
           (N-acetylglucosamine-1-phosphate uridyltransferase);
           Glucosamine-1-phosphate N-acetyltransferase (EC
           2.3.1.157)]
          Length = 433

 Score = 30.0 bits (66), Expect = 3.4
 Identities = 26/95 (27%), Positives = 36/95 (37%), Gaps = 19/95 (20%)
 Frame = -3

Query: 429 IQREKEPSKAHQIKLEVLVKTLQWLGITMDVDEV-----------ECIMA--------CL 307
           +  + E +KA +I LE L K    LG+ M +              EC++         CL
Sbjct: 223 VNSQTERAKAEEIMLERLRKNAMDLGVVMQLPNSIYLEKGVSFKGECVLEQGVRLIGNCL 282

Query: 306 IYKNLIKGYFAHKSKVLVLSKQDPFPKLNGKPV*C 202
           I    IK Y   +   +V S   PF     K V C
Sbjct: 283 IENAHIKAYSVIEESQIVNSSVGPFAHARPKSVIC 317

>GLMU_HELPJ (Q9ZLF6) Bifunctional protein glmU [Includes:|
           UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23)
           (N-acetylglucosamine-1-phosphate uridyltransferase);
           Glucosamine-1-phosphate N-acetyltransferase (EC
           2.3.1.157)]
          Length = 433

 Score = 30.0 bits (66), Expect = 3.4
 Identities = 25/95 (26%), Positives = 36/95 (37%), Gaps = 19/95 (20%)
 Frame = -3

Query: 429 IQREKEPSKAHQIKLEVLVKTLQWLGITMDVDEV-----------ECIMA--------CL 307
           +  + E +KA +I LE L K    LG+ M +              EC++         CL
Sbjct: 223 VNSQTERAKAEEIMLERLRKNAMDLGVVMQLPSSIYLEKGVSFKGECVLEQGVRLIGNCL 282

Query: 306 IYKNLIKGYFAHKSKVLVLSKQDPFPKLNGKPV*C 202
           I    IK Y   +   ++ S   PF     K V C
Sbjct: 283 IENARIKAYSVIEESQIINSSVGPFAHARPKSVIC 317

>POLG_ZYMVS (O36979) Genome polyprotein [Contains: P1 proteinase (N-terminal|
            protein); Helper component proteinase (EC 3.4.22.45)
            (HC-pro); Protein P3; 6 kDa protein 1 (6K1); Cytoplasmic
            inclusion protein (EC 3.6.1.-) (CI); 6 kDa protein 2
            (6K2); Viral ge
          Length = 3083

 Score = 29.6 bits (65), Expect = 4.4
 Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 2/45 (4%)
 Frame = +1

Query: 157  IETFIRCTKLTRYRYALNGLPVQLWEGV--LFAEHKNFAFVGKVS 285
            I   I+C + TR  +  NG+P +++E +     E+KN A  GK+S
Sbjct: 1646 IGVHIQCHESTRIPFYTNGIPDKVYERIWKCIQENKNDALFGKLS 1690

>ELYA_BACYA (P20724) Alkaline elastase YaB precursor (EC 3.4.21.-)|
          Length = 378

 Score = 29.3 bits (64), Expect = 5.8
 Identities = 15/36 (41%), Positives = 21/36 (58%)
 Frame = -2

Query: 481 GET*TPGLPKISEENPYHTEGEGTI*SASNQAGGLG 374
           G +  PG P IS+ N + T+  GTI + +N  G LG
Sbjct: 155 GASFVPGEPNISDGNGHGTQVAGTIAALNNSIGVLG 190

>POLG_ZYMVR (Q89330) Genome polyprotein [Contains: P1 proteinase (N-terminal|
            protein); Helper component proteinase (EC 3.4.22.45)
            (HC-pro); Protein P3; 6 kDa protein 1 (6K1); Cytoplasmic
            inclusion protein (EC 3.6.1.-) (CI); 6 kDa protein 2
            (6K2); Viral ge
          Length = 3083

 Score = 28.9 bits (63), Expect = 7.6
 Identities = 15/45 (33%), Positives = 26/45 (57%), Gaps = 2/45 (4%)
 Frame = +1

Query: 157  IETFIRCTKLTRYRYALNGLPVQLWEGV--LFAEHKNFAFVGKVS 285
            I   I+C + TR  +  NG+P +++E +     E+KN A  G++S
Sbjct: 1646 IGVHIQCNENTRIPFYTNGIPDRVYEKIWKCIQENKNDALFGRLS 1690

>UBX2_YEAST (Q04228) UBX domain-containing protein 2 (Secretion lowering|
           protein 1)
          Length = 584

 Score = 28.9 bits (63), Expect = 7.6
 Identities = 14/50 (28%), Positives = 28/50 (56%), Gaps = 2/50 (4%)
 Frame = -3

Query: 483 LEKLELQVYRRLVK--KIHIIQREKEPSKAHQIKLEVLVKTLQWLGITMD 340
           ++KL+   Y++ ++  +I  I++EK    A  +KL    + L+WL   +D
Sbjct: 371 IKKLQEDAYKKSLEMDRIKAIEKEKSLKHAQDLKLNSTARQLKWLKACID 420

>TRUA_PROMP (Q7TU31) tRNA pseudouridine synthase A (EC 5.4.99.12) (tRNA-uridine|
           isomerase I) (tRNA pseudouridylate synthase I)
          Length = 268

 Score = 28.5 bits (62), Expect = 9.9
 Identities = 18/72 (25%), Positives = 37/72 (51%), Gaps = 2/72 (2%)
 Frame = +1

Query: 61  KCLQTLQLK--YKCCYNQSHGNFTYTYVFSTSKIIETFIRCTKLTRYRYALNGLPVQLWE 234
           + L+++++K  +  CY+  + +  Y YV + +KI   F+      RY+  L+ + + +  
Sbjct: 88  RILESVEVKSSWHACYSAVYRH--YRYVINNNKIPNLFLNKWSWHRYQKYLDEVSMSIAL 145

Query: 235 GVLFAEHKNFAF 270
             +  EH  FAF
Sbjct: 146 DGMIGEHDFFAF 157


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,567,443
Number of Sequences: 219361
Number of extensions: 1310657
Number of successful extensions: 2942
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 2890
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2934
length of database: 80,573,946
effective HSP length: 103
effective length of database: 57,979,763
effective search space used: 3362826254
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)