>MSH2_MAIZE (Q9XGC9) DNA mismatch repair protein MSH2 (MUS1)|
          Length = 942

 Score =  211 bits (538), Expect = 4e-55
 Identities = 101/121 (83%), Positives = 112/121 (92%)
 Frame = +2

Query: 53  MDSEDFLPEGGKLPELKLDARQAQGFISFFKKLPKDPRAIRLFDRRDYYTAHGENATFIA 232
           M+ +DF PEGGKLPE KLDARQAQGFISFFKKLP+DPRA+RLFDRRDYYTAHGENATFIA
Sbjct: 1   MEGDDFTPEGGKLPEFKLDARQAQGFISFFKKLPQDPRAVRLFDRRDYYTAHGENATFIA 60

Query: 233 KAYYHTMTALRQLGGNSDGISSVSVSRAMFETIARNLLLDRTDHTLELYEGSGSSWRLTX 412
           + YYHTM+ALRQLG +SDGI S SVS+AMFETIARN+LL+RTD TLELYEGSGS+WRLT 
Sbjct: 61  RTYYHTMSALRQLGSSSDGILSASVSKAMFETIARNILLERTDCTLELYEGSGSNWRLTK 120

Query: 413 S 415
           S
Sbjct: 121 S 121

>MSH2_ARATH (O24617) DNA mismatch repair protein MSH2 (AtMsh2)|
          Length = 937

 Score =  177 bits (448), Expect = 1e-44
 Identities = 83/110 (75%), Positives = 96/110 (87%)
 Frame = +2

Query: 77  EGGKLPELKLDARQAQGFISFFKKLPKDPRAIRLFDRRDYYTAHGENATFIAKAYYHTMT 256
           E  KLPELKLDA+QAQGF+SF+K LP D RA+R FDR+DYYTAHGEN+ FIAK YYHT T
Sbjct: 7   EQNKLPELKLDAKQAQGFLSFYKTLPNDTRAVRFFDRKDYYTAHGENSVFIAKTYYHTTT 66

Query: 257 ALRQLGGNSDGISSVSVSRAMFETIARNLLLDRTDHTLELYEGSGSSWRL 406
           ALRQLG  S+ +SSVS+SR MFETIAR+LLL+R DHT+ELYEGSGS+WRL
Sbjct: 67  ALRQLGSGSNALSSVSISRNMFETIARDLLLERNDHTVELYEGSGSNWRL 116

>MSH2_NEUCR (O13396) DNA mismatch repair protein msh-2|
          Length = 937

 Score = 75.5 bits (184), Expect = 5e-14
 Identities = 41/87 (47%), Positives = 57/87 (65%), Gaps = 2/87 (2%)
 Frame = +2

Query: 92  PELKLDARQAQGFISFFKKLPK-DPRAIRLFDRRDYYTAHGENATFIAKAYYHTMTALRQ 268
           PELK+D     GFI F+K LP+    AIR+FDR D+YTAHG++ATFIA+  Y T + +RQ
Sbjct: 5   PELKVD--DEHGFIRFYKSLPQLGEEAIRIFDRGDWYTAHGDDATFIARTVYKTTSVIRQ 62

Query: 269 LG-GNSDGISSVSVSRAMFETIARNLL 346
           LG  +  G+ SV+++  +F    R  L
Sbjct: 63  LGRSDHTGLPSVTMTVTVFRQFLREAL 89

>MSH2_CERAE (Q5XXB5) DNA mismatch repair protein Msh2 (MutS protein homolog 2)|
          Length = 933

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 35/97 (36%), Positives = 61/97 (62%), Gaps = 2/97 (2%)
 Frame = +2

Query: 98  LKLDARQAQGFISFFKKLPKDPRA-IRLFDRRDYYTAHGENATFIAKAYYHTMTALRQLG 274
           L+L++    GF+ FF+ +P+ P   +RLFDR D+YTAHGE+A   A+  + T   ++ +G
Sbjct: 9   LQLESAAEVGFVRFFQSMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMG 68

Query: 275 -GNSDGISSVSVSRAMFETIARNLLLDRTDHTLELYE 382
              +  + SV +S+  FE+  ++LLL R  + +E+Y+
Sbjct: 69  PAGAKNLQSVVLSKMNFESFVKDLLLVR-QYRVEVYK 104

>MSH2_MOUSE (P43247) DNA mismatch repair protein Msh2 (MutS protein homolog 2)|
          Length = 935

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 36/102 (35%), Positives = 61/102 (59%), Gaps = 2/102 (1%)
 Frame = +2

Query: 98  LKLDARQAQGFISFFKKLPKDPRA-IRLFDRRDYYTAHGENATFIAKAYYHTMTALRQLG 274
           L+L+     GF+ FF+ +P+ P   +RLFDR D+YTAHGE+A   A+  + T   ++ +G
Sbjct: 9   LQLEGAAEAGFVRFFEGMPEKPSTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMG 68

Query: 275 -GNSDGISSVSVSRAMFETIARNLLLDRTDHTLELYEGSGSS 397
              S  + SV +S+  FE+  ++LLL R  + +E+Y+    +
Sbjct: 69  PAGSKTLQSVVLSKMNFESFVKDLLLVR-QYRVEVYKNKAGN 109

>MSH2_HUMAN (P43246) DNA mismatch repair protein Msh2 (MutS protein homolog 2)|
          Length = 934

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 35/97 (36%), Positives = 61/97 (62%), Gaps = 2/97 (2%)
 Frame = +2

Query: 98  LKLDARQAQGFISFFKKLPKDPRA-IRLFDRRDYYTAHGENATFIAKAYYHTMTALRQLG 274
           L+L++    GF+ FF+ +P+ P   +RLFDR D+YTAHGE+A   A+  + T   ++ +G
Sbjct: 9   LQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMG 68

Query: 275 -GNSDGISSVSVSRAMFETIARNLLLDRTDHTLELYE 382
              +  + SV +S+  FE+  ++LLL R  + +E+Y+
Sbjct: 69  PAGAKNLQSVVLSKMNFESFVKDLLLVR-QYRVEVYK 104

>MSH2_BOVIN (Q3MHE4) DNA mismatch repair protein Msh2 (MutS protein homolog 2)|
          Length = 934

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 35/97 (36%), Positives = 60/97 (61%), Gaps = 2/97 (2%)
 Frame = +2

Query: 98  LKLDARQAQGFISFFKKLPKDPRA-IRLFDRRDYYTAHGENATFIAKAYYHTMTALRQLG 274
           L+LD+    GF+ FF+ +P+ P   +RLFDR D+YTAH E+A   A+  + T   ++ +G
Sbjct: 9   LQLDSAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHREDALLAAREVFKTQGVVKYMG 68

Query: 275 -GNSDGISSVSVSRAMFETIARNLLLDRTDHTLELYE 382
              +  + SV +S+  FE+  ++LLL R  + +E+Y+
Sbjct: 69  PAGAKTLESVVLSKMNFESFVKDLLLVR-QYRVEVYK 104

>MSH2_RAT (P54275) DNA mismatch repair protein Msh2 (MutS protein homolog 2)|
          Length = 933

 Score = 62.0 bits (149), Expect = 5e-10
 Identities = 33/102 (32%), Positives = 60/102 (58%), Gaps = 2/102 (1%)
 Frame = +2

Query: 98  LKLDARQAQGFISFFKKLPKDPRA-IRLFDRRDYYTAHGENATFIAKAYYHTMTALRQLG 274
           L+L+     GF+ FF+ +P+ P   + LFDR D+YTAHGE+A   A+  + T   ++ +G
Sbjct: 9   LQLEGAAEVGFVRFFEGMPEKPSTTVGLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMG 68

Query: 275 -GNSDGISSVSVSRAMFETIARNLLLDRTDHTLELYEGSGSS 397
              +  + +V +S+  FE+  ++LLL R  + +E+Y+    +
Sbjct: 69  PAGAKTLQTVVLSKMNFESFVKDLLLVR-HYRVEVYKNKAGN 109

>MSH2_SCHPO (O74773) DNA mismatch repair protein msh2|
          Length = 982

 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 26/71 (36%), Positives = 46/71 (64%)
 Frame = +2

Query: 134 SFFKKLPKDPRAIRLFDRRDYYTAHGENATFIAKAYYHTMTALRQLGGNSDGISSVSVSR 313
           +F++K+PKD   +R+FDR ++Y A GE+A+F+A+  YHT + L+    N    S  ++S 
Sbjct: 20  NFYEKMPKDTNTVRVFDRGEFYVAIGEDASFVAQNAYHTTSVLKH--HNVSNTSYCNLSP 77

Query: 314 AMFETIARNLL 346
           ++F   A ++L
Sbjct: 78  SLFIKFAEDVL 88

>MSH2_DROME (P43248) DNA mismatch repair protein spellchecker 1|
          Length = 917

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 35/109 (32%), Positives = 54/109 (49%), Gaps = 4/109 (3%)
 Frame = +2

Query: 92  PELKLDARQAQGFISFFKKLPKDPRA-IRLFDRRDYYTAHG-ENATFIAKAYYHTMTALR 265
           P L +D    + FI F  KL + P   +R FD  D YT HG ++   +AK  Y +   + 
Sbjct: 12  PTLNMDTNARRNFIKFHAKLGEKPATTVRFFDHTDRYTVHGSDDCELVAKIVYKSTAFIG 71

Query: 266 QL--GGNSDGISSVSVSRAMFETIARNLLLDRTDHTLELYEGSGSSWRL 406
            L      + +  VS+S+  FE   R LLL R ++ +E+Y  + S W +
Sbjct: 72  ALLPDDKKETLQFVSMSKGNFELAVRELLLVR-NYRVEVYVKNSSDWEI 119

>MSH2_YEAST (P25847) DNA mismatch repair protein MSH2|
          Length = 964

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 39/119 (32%), Positives = 61/119 (51%), Gaps = 11/119 (9%)
 Frame = +2

Query: 92  PELKL-DARQAQGFISFFKKLPKDP-RAIRLFDRRDYYTAHGENATFIAKAYYHTMTALR 265
           PELK  D  + + F   +  LPK P + IRL D+ DYYT  G +A F+A + YHT + L+
Sbjct: 6   PELKFSDVSEERNFYKKYTGLPKKPLKTIRLVDKGDYYTVIGSDAIFVADSVYHTQSVLK 65

Query: 266 QLGGNSDGISS---------VSVSRAMFETIARNLLLDRTDHTLELYEGSGSSWRLTXS 415
                 D +++         V+VS  +  T+ +  LLD   + +E+Y+     W+L  S
Sbjct: 66  NC--QLDPVTAKNFHEPTKYVTVSLQVLATLLKLCLLD-LGYKVEIYD---KGWKLIKS 118

>GFI1_HUMAN (Q99684) Zinc finger protein Gfi-1 (Growth factor independence 1)|
          Length = 422

 Score = 32.7 bits (73), Expect = 0.35
 Identities = 17/36 (47%), Positives = 18/36 (50%)
 Frame = +1

Query: 19  PALPPSTPAGLYGQRRLLAGGGKAPGAQARCEASPG 126
           PA  P  PA LYG +R  A GG   GA   C A  G
Sbjct: 157 PAPEPGHPAALYGPKR--AAGGAGAGAPGSCSAGAG 190

>PI5PA_MOUSE (P59644) Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC|
           3.1.3.56)
          Length = 1003

 Score = 32.3 bits (72), Expect = 0.45
 Identities = 15/40 (37%), Positives = 20/40 (50%)
 Frame = +1

Query: 4   SPSRSPALPPSTPAGLYGQRRLLAGGGKAPGAQARCEASP 123
           SP+RSP LPP+    L       AG G+ P    + + SP
Sbjct: 356 SPNRSPCLPPAPEVALPKPVTQAAGSGRCPSPNLQAQESP 395

>ATM_GIBZE (Q4IB89) Serine/threonine-protein kinase TEL1 (EC 2.7.11.1)|
           (DNA-damage checkpoint kinase TEL1) (Telomere length
           regulation protein 1) (ATM homolog)
          Length = 2813

 Score = 31.6 bits (70), Expect = 0.78
 Identities = 20/47 (42%), Positives = 27/47 (57%)
 Frame = +1

Query: 16  SPALPPSTPAGLYGQRRLLAGGGKAPGAQARCEASPGFHLLLQEVAE 156
           SPAL  S+PA   G  R  +GG   P  Q++  A+PG   LL++V E
Sbjct: 194 SPALTRSSPAPGSGYSR--SGGRSTPSTQSQRRAAPGEGGLLKDVLE 238

>NOTC2_MOUSE (O35516) Neurogenic locus notch homolog protein 2 precursor (Notch|
           2) (Motch B) [Contains: Notch 2 extracellular
           truncation; Notch 2 intracellular domain]
          Length = 2470

 Score = 30.4 bits (67), Expect = 1.7
 Identities = 13/32 (40%), Positives = 17/32 (53%)
 Frame = +1

Query: 256 CLKATGR*L*WNLKCQC*QGYV*DHCPQPFVR 351
           CL   G     + +CQC QG+   HC  P+VR
Sbjct: 198 CLNLPG-----SYRCQCGQGFTGQHCDSPYVR 224

>RASH_MSVHA (P01115) Transforming protein p29 precursor [Contains: Transforming|
           protein p21]
          Length = 241

 Score = 30.4 bits (67), Expect = 1.7
 Identities = 17/47 (36%), Positives = 25/47 (53%)
 Frame = +1

Query: 1   ISPSRSPALPPSTPAGLYGQRRLLAGGGKAPGAQARCEASPGFHLLL 141
           ++P R+PALP   P    G     +GG +APG  A  EA   + L++
Sbjct: 18  VAPVRAPALPRPAP----GAVAPASGGARAPGLAAPVEAMTEYKLVV 60

>PI5PA_RAT (Q9JMC1) Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC|
           3.1.3.56) (Proline-rich inositol polyphosphate
           5-phosphatase)
          Length = 1001

 Score = 30.0 bits (66), Expect = 2.3
 Identities = 15/40 (37%), Positives = 20/40 (50%)
 Frame = +1

Query: 4   SPSRSPALPPSTPAGLYGQRRLLAGGGKAPGAQARCEASP 123
           SP+RSP +PP+    L       AG GK P    + + SP
Sbjct: 356 SPNRSPCVPPAPEVALPRPVTQGAGPGKCPSPNLQTQESP 395

>MURG_BRUME (Q8YI66) UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide)|
           pyrophosphoryl-undecaprenol N-acetylglucosamine
           transferase (EC 2.4.1.227)
           (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc
           transferase)
          Length = 379

 Score = 29.6 bits (65), Expect = 2.9
 Identities = 23/52 (44%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
 Frame = +1

Query: 4   SPSRSPAL----PPSTPAGLYGQRRLLAGGGKAPGAQARCEASPGFHLLLQE 147
           +P RSP L     P TPAG   + RLL  GG + GAQ   +A P    LL E
Sbjct: 166 NPVRSPVLVAAATPYTPAGKDDRFRLLVFGG-SQGAQFFSQAIPAAVALLPE 216

>MURG_BRUAB (Q57C78) UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide)|
           pyrophosphoryl-undecaprenol N-acetylglucosamine
           transferase (EC 2.4.1.227)
           (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc
           transferase)
          Length = 379

 Score = 29.6 bits (65), Expect = 2.9
 Identities = 23/52 (44%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
 Frame = +1

Query: 4   SPSRSPAL----PPSTPAGLYGQRRLLAGGGKAPGAQARCEASPGFHLLLQE 147
           +P RSP L     P TPAG   + RLL  GG + GAQ   +A P    LL E
Sbjct: 166 NPVRSPVLVAAATPYTPAGKDDRFRLLVFGG-SQGAQFFSQAIPAAVALLPE 216

>DPO41_METMA (Q8PYH6) DNA polymerase IV 1 (EC 2.7.7.7) (Pol IV 1)|
          Length = 365

 Score = 29.3 bits (64), Expect = 3.8
 Identities = 20/65 (30%), Positives = 30/65 (46%)
 Frame = +2

Query: 143 KKLPKDPRAIRLFDRRDYYTAHGENATFIAKAYYHTMTALRQLGGNSDGISSVSVSRAMF 322
           KKL  +P A+ L  R+D+YT+  +    I ++Y           GN D    +SV  A  
Sbjct: 68  KKL--NPEAVFLPVRKDFYTSVSDRIMEILRSYADP--------GNGDSFEQISVDEAFL 117

Query: 323 ETIAR 337
           E+  R
Sbjct: 118 ESSER 122

>Y406_METJA (Q57849) Hypothetical sugar kinase MJ0406|
          Length = 302

 Score = 28.9 bits (63), Expect = 5.0
 Identities = 25/112 (22%), Positives = 47/112 (41%), Gaps = 2/112 (1%)
 Frame = +2

Query: 80  GGKLPELKLDARQAQGFISFFKKLPKDPRAIRLFDRRDYYTAHGENATFIAKAYYHTMTA 259
           GGK+ ++      A  +I   +K P+   +I++   R YY     N          T   
Sbjct: 2   GGKMEKITCVGHTALDYIFNVEKFPEPNTSIQIPSARKYYGGAAAN----------TAVG 51

Query: 260 LRQLGGNSDGISSV--SVSRAMFETIARNLLLDRTDHTLELYEGSGSSWRLT 409
           +++LG NS+ +S V      + +E   +NL ++ +       E +  +W  T
Sbjct: 52  IKKLGVNSELLSCVGYDFKNSGYERYLKNLDINISKLYYSEEEETPKAWIFT 103

>KPC2_DROME (P13677) Protein kinase C, eye isozyme (EC 2.7.11.13) (PKC)|
          (dPKC53E(EY)) (Protein INAC) (Inactivation no
          after-potential C protein) (Photoreceptor-specific PKC)
          (Eye-PKC)
          Length = 700

 Score = 28.5 bits (62), Expect = 6.6
 Identities = 12/24 (50%), Positives = 14/24 (58%)
 Frame = +1

Query: 25 LPPSTPAGLYGQRRLLAGGGKAPG 96
          LPPS P+   G +   AG GK PG
Sbjct: 14 LPPSVPSAAPGAKAPAAGAGKGPG 37

>TOPI_DROME (Q9VH70) Testis-specific zinc finger protein topi (Protein|
           matotopetli)
          Length = 814

 Score = 28.5 bits (62), Expect = 6.6
 Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
 Frame = -2

Query: 299 HLRFHQSYRPVALRQSLCD-SMPLQ*RLHSHHEQCN 195
           HLRFHQ  +P   ++  CD    ++  L+ H  +C+
Sbjct: 529 HLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCH 564

>MORC2_HUMAN (Q9Y6X9) MORC family CW-type zinc finger 2 (Zinc finger CW-type|
           coiled-coil domain protein 1)
          Length = 970

 Score = 28.1 bits (61), Expect = 8.6
 Identities = 15/39 (38%), Positives = 21/39 (53%)
 Frame = +1

Query: 4   SPSRSPALPPSTPAGLYGQRRLLAGGGKAPGAQARCEAS 120
           +PSR P+LP   PA    +  +++   K P   AR EAS
Sbjct: 563 APSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAS 601

>SEM6C_HUMAN (Q9H3T2) Semaphorin-6C precursor (Semaphorin Y) (Sema Y)|
          Length = 930

 Score = 28.1 bits (61), Expect = 8.6
 Identities = 18/54 (33%), Positives = 24/54 (44%), Gaps = 9/54 (16%)
 Frame = +1

Query: 4   SPSRSPALPPSTPAGLYGQRRLLAGGGKAP---------GAQARCEASPGFHLL 138
           +P+R     P+   G+ G RRL   G +AP         G  +R    PG HLL
Sbjct: 831 APARPALSAPAPRLGVGGGRRLPFSGHRAPPALLTRVPSGGPSRYSGGPGKHLL 884

>SKI3_YEAST (P17883) Superkiller 3 protein|
          Length = 1432

 Score = 28.1 bits (61), Expect = 8.6
 Identities = 13/26 (50%), Positives = 16/26 (61%)
 Frame = +2

Query: 104 LDARQAQGFISFFKKLPKDPRAIRLF 181
           LD   A   I +FKK PKDP A+ L+
Sbjct: 297 LDNMDAPLIIKYFKKFPKDPLAMILY 322

>CDC2D_ANTMA (Q38775) Cell division control protein 2 homolog D (EC 2.7.11.22)|
           (EC 2.7.11.23)
          Length = 312

 Score = 28.1 bits (61), Expect = 8.6
 Identities = 14/67 (20%), Positives = 29/67 (43%), Gaps = 2/67 (2%)
 Frame = +2

Query: 131 ISFFKKLPKDPRAIRLFDRRDYYTAHGENATFIAKAYYHT--MTALRQLGGNSDGISSVS 304
           +S  + L +DP  +RL D +      G+   ++   Y  T     +R      + I+ ++
Sbjct: 62  VSLLRMLSRDPHVVRLLDVKQGQNKEGKTVLYLVFEYMDTDLKKYIRSFKQTGESIAPMN 121

Query: 305 VSRAMFE 325
           V   M++
Sbjct: 122 VKSLMYQ 128


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,446,324
Number of Sequences: 219361
Number of extensions: 1110670
Number of successful extensions: 3364
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 3220
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3351
length of database: 80,573,946
effective HSP length: 100
effective length of database: 58,637,846
effective search space used: 2228238148
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)