>VPP1_BOVIN (Q29466) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 1 (V-ATPase 116-kDa isoform a1) (Clathrin-coated
           vesicle/synaptic vesicle proton pump 116 kDa subunit)
           (Vacuolar proton pump subunit 1) (Vacuolar adenosine
           triphosphatase
          Length = 838

 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 39/86 (45%), Positives = 58/86 (67%)
 Frame = +1

Query: 205 DLMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMS 384
           +L RSE M L Q+ + +E+A+  VS LG+LG +QF+DLN D + FQR +  +++RC EM 
Sbjct: 3   ELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMD 62

Query: 385 RKLRXFKEQMSKAGIQVPPMQSTETP 462
           RKLR  ++++ KA I  P M + E P
Sbjct: 63  RKLRFVEKEIRKANI--PIMDTGENP 86

>VPP1_PONPY (Q5R422) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 1 (V-ATPase 116-kDa isoform a1)
          Length = 837

 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 39/86 (45%), Positives = 58/86 (67%)
 Frame = +1

Query: 205 DLMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMS 384
           +L RSE M L Q+ + +E+A+  VS LG+LG +QF+DLN D + FQR +  +++RC EM 
Sbjct: 3   ELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMD 62

Query: 385 RKLRXFKEQMSKAGIQVPPMQSTETP 462
           RKLR  ++++ KA I  P M + E P
Sbjct: 63  RKLRFVEKEIRKANI--PIMDTGENP 86

>VPP1_HUMAN (Q93050) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 1 (V-ATPase 116-kDa isoform a1) (Clathrin-coated
           vesicle/synaptic vesicle proton pump 116 kDa subunit)
           (Vacuolar proton pump subunit 1) (Vacuolar adenosine
           triphosphatase
          Length = 837

 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 39/86 (45%), Positives = 58/86 (67%)
 Frame = +1

Query: 205 DLMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMS 384
           +L RSE M L Q+ + +E+A+  VS LG+LG +QF+DLN D + FQR +  +++RC EM 
Sbjct: 3   ELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMD 62

Query: 385 RKLRXFKEQMSKAGIQVPPMQSTETP 462
           RKLR  ++++ KA I  P M + E P
Sbjct: 63  RKLRFVEKEIRKANI--PIMDTGENP 86

>VPP1_MOUSE (Q9Z1G4) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 1 (V-ATPase 116-kDa isoform a1) (Clathrin-coated
           vesicle/synaptic vesicle proton pump 116 kDa subunit)
           (Vacuolar proton pump subunit 1) (Vacuolar adenosine
           triphosphatase
          Length = 839

 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 39/86 (45%), Positives = 58/86 (67%)
 Frame = +1

Query: 205 DLMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMS 384
           +L RSE M L Q+ + +E+A+  VS LG+LG +QF+DLN D + FQR +  +++RC EM 
Sbjct: 3   ELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMD 62

Query: 385 RKLRXFKEQMSKAGIQVPPMQSTETP 462
           RKLR  ++++ KA I  P M + E P
Sbjct: 63  RKLRFVEKEIRKANI--PIMDTGENP 86

>VPP1_CAEEL (P30628) Probable vacuolar proton translocating ATPase 116 kDa|
           subunit a (Uncoordinated protein 32)
          Length = 905

 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 37/89 (41%), Positives = 58/89 (65%)
 Frame = +1

Query: 196 PSMDLMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCA 375
           P   + RSE M L Q+ + +++++  V+ LG+LGL+QF+DLN D S FQR Y  +++RC 
Sbjct: 12  PQPGIYRSEQMCLAQLYLQSDASYQCVAELGELGLVQFRDLNPDVSSFQRKYVNEVRRCD 71

Query: 376 EMSRKLRXFKEQMSKAGIQVPPMQSTETP 462
           EM RKLR  + ++ K   Q+P + + E P
Sbjct: 72  EMERKLRYLEREIKKD--QIPMLDTGENP 98

>VPP1_RAT (P25286) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 1 (V-ATPase 116-kDa isoform a1) (Clathrin-coated
           vesicle/synaptic vesicle proton pump 116 kDa subunit)
           (Vacuolar proton pump subunit 1) (Vacuolar adenosine
           triphosphatase su
          Length = 838

 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 38/86 (44%), Positives = 57/86 (66%)
 Frame = +1

Query: 205 DLMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMS 384
           +L RSE M L Q+ + +E+A+  VS L +LG +QF+DLN D + FQR +  +++RC EM 
Sbjct: 3   ELFRSEEMTLAQLFLQSEAAYCCVSELEELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMD 62

Query: 385 RKLRXFKEQMSKAGIQVPPMQSTETP 462
           RKLR  ++++ KA I  P M + E P
Sbjct: 63  RKLRFVEKEIRKANI--PIMDTGENP 86

>VPP3_HUMAN (Q13488) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 3 (V-ATPase 116-kDa isoform a3) (Osteoclastic
           proton pump 116 kDa subunit) (OC-116 kDa) (OC116)
           (T-cell immune regulator 1) (T cell immune response
           cDNA7 protein) (TIRC7)
          Length = 830

 Score = 75.9 bits (185), Expect = 5e-14
 Identities = 32/78 (41%), Positives = 53/78 (67%)
 Frame = +1

Query: 208 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 387
           + RSE + L+Q+ +PT +A+  VS LG+LGL++F+DLNA  S FQR +   + RC E+ +
Sbjct: 4   MFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVWRCEELEK 63

Query: 388 KLRXFKEQMSKAGIQVPP 441
                +E++ +AG+ +PP
Sbjct: 64  TFTFLQEEVRRAGLVLPP 81

>VPP4_MOUSE (Q920R6) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 4 (V-ATPase 116-kDa isoform a4) (Vacuolar proton
           translocating ATPase 116 kDa subunit a kidney isoform)
          Length = 833

 Score = 75.1 bits (183), Expect = 8e-14
 Identities = 36/86 (41%), Positives = 55/86 (63%)
 Frame = +1

Query: 208 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 387
           + RSE M L QV +  E+A+  V+ LG+LGL+QFKDLNA+ + FQR +  +++RC  + R
Sbjct: 4   VFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCESLER 63

Query: 388 KLRXFKEQMSKAGIQVPPMQSTETPL 465
            LR  +++M    +   P +  ETPL
Sbjct: 64  ILRFLEDEMQNEILIQVPEKDAETPL 89

>VPP4_HUMAN (Q9HBG4) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 4 (V-ATPase 116-kDa isoform a4) (Vacuolar proton
           translocating ATPase 116 kDa subunit a kidney isoform)
          Length = 840

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 33/86 (38%), Positives = 53/86 (61%)
 Frame = +1

Query: 208 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 387
           + RSE M L Q+ +  E+A+  V+ LG+LGL+QFKDLN + + FQR +  +++RC  + R
Sbjct: 4   VFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLER 63

Query: 388 KLRXFKEQMSKAGIQVPPMQSTETPL 465
            LR  +++M    +     +S  TPL
Sbjct: 64  ILRFLEDEMQNEIVVQLLEKSPLTPL 89

>VPP2_MOUSE (P15920) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 2 (V-ATPase 116-kDa isoform a2) (Immune
           suppressor factor J6B7)
          Length = 856

 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 31/77 (40%), Positives = 52/77 (67%)
 Frame = +1

Query: 208 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 387
           L RSE+M L Q+ + + +A+  +S LG+ GL+QF+DLN + S FQR +  ++KRC E+ R
Sbjct: 4   LFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELER 63

Query: 388 KLRXFKEQMSKAGIQVP 438
            L    +++++A I +P
Sbjct: 64  ILVYLVQEITRADIPLP 80

>VPP2_HUMAN (Q9Y487) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 2 (V-ATPase 116-kDa isoform a2) (TJ6)
          Length = 856

 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 31/77 (40%), Positives = 51/77 (66%)
 Frame = +1

Query: 208 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 387
           L RSE M L Q+ + + +A+  +S LG+ GL+QF+DLN + S FQR +  ++KRC E+ R
Sbjct: 4   LFRSETMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELER 63

Query: 388 KLRXFKEQMSKAGIQVP 438
            L    +++++A I +P
Sbjct: 64  ILVYLVQEINRADIPLP 80

>VPP2_BOVIN (O97681) Vacuolar proton translocating ATPase 116 kDa subunit A|
           isoform 2 (V-ATPase 116-kDa isoform a2)
          Length = 854

 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 30/77 (38%), Positives = 51/77 (66%)
 Frame = +1

Query: 208 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 387
           L RSE M L Q+ + + +A+  +S LG+ GL++F+DLN + S FQR +  ++KRC E+ R
Sbjct: 4   LFRSETMCLAQLFLQSGTAYECLSVLGEKGLVEFRDLNQNVSSFQRKFVGEVKRCEELER 63

Query: 388 KLRXFKEQMSKAGIQVP 438
            L    +++++A I +P
Sbjct: 64  ILAYLVQEINRADIPLP 80

>VPH1_NEUCR (Q01290) Vacuolar ATP synthase 98 kDa subunit (Vacuolar ATPase 98|
           kDa subunit)
          Length = 856

 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 33/85 (38%), Positives = 50/85 (58%)
 Frame = +1

Query: 214 RSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSRKL 393
           RS  M ++Q+ I  E      + LG+LGL+ F+DLN++ S FQR +   I+R   + R+L
Sbjct: 10  RSADMSMVQLYISNEIGREVCNALGELGLVHFRDLNSELSAFQRAFTQDIRRLDNVERQL 69

Query: 394 RXFKEQMSKAGIQVPPMQSTETPLD 468
           R F  QM KAGI   P++  +  +D
Sbjct: 70  RYFHSQMEKAGI---PLRKFDPDVD 91

>VPH1_YEAST (P32563) Vacuolar ATP synthase subunit a, vacuolar isoform (EC|
           3.6.3.14) (V-ATPase a subunit) (Vacuolar proton pump a
           subunit) (V-ATPase 95 kDa subunit) (Vacuolar pH protein
           1)
          Length = 839

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 29/76 (38%), Positives = 44/76 (57%)
 Frame = +1

Query: 208 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 387
           + RS  M L+Q  IP E +  +   LG LGL+QF+DLN+    FQRT+  +I+R   + R
Sbjct: 7   IFRSAEMALVQFYIPQEISRDSAYTLGQLGLVQFRDLNSKVRAFQRTFVNEIRRLDNVER 66

Query: 388 KLRXFKEQMSKAGIQV 435
           + R F   + K  I++
Sbjct: 67  QYRYFYSLLKKHDIKL 82

>VPH1_SCHPO (O13742) Probable vacuolar ATP synthase 91 kDa subunit (Vacuolar|
           ATPase 91 kDa subunit)
          Length = 805

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 23/55 (41%), Positives = 32/55 (58%)
 Frame = +1

Query: 274 VSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSRKLRXFKEQMSKAGIQVP 438
           +S LG+L  I FKDLN D   FQR++  +I+R  +  R LR    ++   GI VP
Sbjct: 1   MSALGELSTIHFKDLNPDVVAFQRSFVREIRRLTDTERLLRYLHSEIDLNGIHVP 55

>STV1_YEAST (P37296) Vacuolar ATP synthase subunit a, Golgi isoform (EC|
           3.6.3.14) (V-ATPase 101 kDa subunit) (V-ATPase subunit
           AC115) (Similar to VPH1 protein 1)
          Length = 890

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 23/71 (32%), Positives = 34/71 (47%)
 Frame = +1

Query: 208 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 387
           + RS  M  +Q+ IP E        LG + +    DLN D + FQR Y  Q++R  E+ R
Sbjct: 7   IFRSADMTYVQLYIPLEVIREVTFLLGKMSVFMVMDLNKDLTAFQRGYVNQLRRFDEVER 66

Query: 388 KLRXFKEQMSK 420
            +    E + K
Sbjct: 67  MVGFLNEVVEK 77

>FLCN_BOVIN (Q3B7L5) Folliculin|
          Length = 579

 Score = 30.4 bits (67), Expect = 2.4
 Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 3/57 (5%)
 Frame = -3

Query: 336 RAFVCVEVFELDEAQIAEVGDGEVRGLGGDND---LQELHRLRPHQIHRGAAAPSAA 175
           R   C EV      Q A  GDG  RG   D +   +Q   R+R H    GA+A S++
Sbjct: 17  RTLFCTEVLHAPLPQGAGSGDGAGRGEPADEEEGGIQMSSRIRAHSPAEGASAESSS 73

>ARHG2_MOUSE (Q60875) Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid|
           blast crisis-like 1) (LBC'S first cousin) (Oncogene LFC)
           (RHOBIN)
          Length = 596

 Score = 30.0 bits (66), Expect = 3.1
 Identities = 16/57 (28%), Positives = 32/57 (56%)
 Frame = +1

Query: 238 QVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSRKLRXFKE 408
           Q + P  + +  +  LGDL + QF   NA++   ++TY+   + C+  ++ L+ +KE
Sbjct: 304 QALCPGSTRNFVIHRLGDLLISQFSGSNAEQ--MRKTYS---EFCSRHTKALKLYKE 355

>ASA1_ENTFA (P17953) Aggregation substance precursor|
          Length = 1296

 Score = 29.3 bits (64), Expect = 5.3
 Identities = 14/56 (25%), Positives = 27/56 (48%)
 Frame = +1

Query: 289 DLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSRKLRXFKEQMSKAGIQVPPMQSTE 456
           DLG +  KDL A +    +    Q K+ A+ + +L+   E+++K   ++      E
Sbjct: 189 DLGNVSSKDLAAKEKEVDQLQKEQAKKIAQQAAELKAKNEKIAKENAEIAAKNKAE 244

>PSB4_SCHPO (Q9USQ9) Probable proteasome subunit beta type 4 (EC 3.4.25.1)|
          Length = 262

 Score = 28.5 bits (62), Expect = 9.1
 Identities = 17/49 (34%), Positives = 27/49 (55%), Gaps = 1/49 (2%)
 Frame = -3

Query: 363 DLCSVGALKRAFVCVEVFELDEAQIAEVGDGEVRGLGGD-NDLQELHRL 220
           +L S G+L R +        D  ++ +VGD  + G GGD +D Q++ RL
Sbjct: 61  NLASYGSLARFY--------DVERLTKVGDNTIVGAGGDISDYQQIQRL 101

>GIDA_XANOR (Q5H6D9) tRNA uridine 5-carboxymethylaminomethyl modification|
           enzyme gidA (Glucose-inhibited division protein A)
          Length = 634

 Score = 28.5 bits (62), Expect = 9.1
 Identities = 14/33 (42%), Positives = 18/33 (54%)
 Frame = +1

Query: 271 AVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKR 369
           A++H  DL  IQ++ LNA K P  R    Q  R
Sbjct: 70  AMAHAADLAGIQWRTLNASKGPAVRATRCQADR 102


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,324,383
Number of Sequences: 219361
Number of extensions: 868772
Number of successful extensions: 2893
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 2818
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2893
length of database: 80,573,946
effective HSP length: 103
effective length of database: 57,979,763
effective search space used: 3072927439
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)