>VPP1_MOUSE (Q9Z1G4) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 1 (V-ATPase 116-kDa isoform a1) (Clathrin-coated
           vesicle/synaptic vesicle proton pump 116 kDa subunit)
           (Vacuolar proton pump subunit 1) (Vacuolar adenosine
           triphosphatase
          Length = 839

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 44/109 (40%), Positives = 68/109 (62%), Gaps = 3/109 (2%)
 Frame = +3

Query: 180 DLMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMS 359
           +L RSE M L Q+ + +E+A+  VS LG+LG +QF+DLN D + FQR +  +++RC EM 
Sbjct: 3   ELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMD 62

Query: 360 RKLRFFKEQMSKAGIQVPPM---PSTETPLDFDDMEVKLGELES*LTEV 497
           RKLRF ++++ KA I +      P    P D  D+E    ++E+ L E+
Sbjct: 63  RKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEI 111

>VPP1_BOVIN (Q29466) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 1 (V-ATPase 116-kDa isoform a1) (Clathrin-coated
           vesicle/synaptic vesicle proton pump 116 kDa subunit)
           (Vacuolar proton pump subunit 1) (Vacuolar adenosine
           triphosphatase
          Length = 838

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 44/109 (40%), Positives = 68/109 (62%), Gaps = 3/109 (2%)
 Frame = +3

Query: 180 DLMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMS 359
           +L RSE M L Q+ + +E+A+  VS LG+LG +QF+DLN D + FQR +  +++RC EM 
Sbjct: 3   ELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMD 62

Query: 360 RKLRFFKEQMSKAGIQVPPM---PSTETPLDFDDMEVKLGELES*LTEV 497
           RKLRF ++++ KA I +      P    P D  D+E    ++E+ L E+
Sbjct: 63  RKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEI 111

>VPP1_PONPY (Q5R422) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 1 (V-ATPase 116-kDa isoform a1)
          Length = 837

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 44/109 (40%), Positives = 68/109 (62%), Gaps = 3/109 (2%)
 Frame = +3

Query: 180 DLMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMS 359
           +L RSE M L Q+ + +E+A+  VS LG+LG +QF+DLN D + FQR +  +++RC EM 
Sbjct: 3   ELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMD 62

Query: 360 RKLRFFKEQMSKAGIQVPPM---PSTETPLDFDDMEVKLGELES*LTEV 497
           RKLRF ++++ KA I +      P    P D  D+E    ++E+ L E+
Sbjct: 63  RKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEI 111

>VPP1_HUMAN (Q93050) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 1 (V-ATPase 116-kDa isoform a1) (Clathrin-coated
           vesicle/synaptic vesicle proton pump 116 kDa subunit)
           (Vacuolar proton pump subunit 1) (Vacuolar adenosine
           triphosphatase
          Length = 837

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 44/109 (40%), Positives = 68/109 (62%), Gaps = 3/109 (2%)
 Frame = +3

Query: 180 DLMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMS 359
           +L RSE M L Q+ + +E+A+  VS LG+LG +QF+DLN D + FQR +  +++RC EM 
Sbjct: 3   ELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMD 62

Query: 360 RKLRFFKEQMSKAGIQVPPM---PSTETPLDFDDMEVKLGELES*LTEV 497
           RKLRF ++++ KA I +      P    P D  D+E    ++E+ L E+
Sbjct: 63  RKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEI 111

>VPP1_RAT (P25286) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 1 (V-ATPase 116-kDa isoform a1) (Clathrin-coated
           vesicle/synaptic vesicle proton pump 116 kDa subunit)
           (Vacuolar proton pump subunit 1) (Vacuolar adenosine
           triphosphatase su
          Length = 838

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 43/109 (39%), Positives = 67/109 (61%), Gaps = 3/109 (2%)
 Frame = +3

Query: 180 DLMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMS 359
           +L RSE M L Q+ + +E+A+  VS L +LG +QF+DLN D + FQR +  +++RC EM 
Sbjct: 3   ELFRSEEMTLAQLFLQSEAAYCCVSELEELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMD 62

Query: 360 RKLRFFKEQMSKAGIQVPPM---PSTETPLDFDDMEVKLGELES*LTEV 497
           RKLRF ++++ KA I +      P    P D  D+E    ++E+ L E+
Sbjct: 63  RKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEI 111

>VPP1_CAEEL (P30628) Probable vacuolar proton translocating ATPase 116 kDa|
           subunit a (Uncoordinated protein 32)
          Length = 905

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 44/114 (38%), Positives = 69/114 (60%), Gaps = 5/114 (4%)
 Frame = +3

Query: 171 PPMDLMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCA 350
           P   + RSE M L Q+ + +++++  V+ LG+LGL+QF+DLN D S FQR Y  +++RC 
Sbjct: 12  PQPGIYRSEQMCLAQLYLQSDASYQCVAELGELGLVQFRDLNPDVSSFQRKYVNEVRRCD 71

Query: 351 EMSRKLRFFKEQMSKAGIQVPPM-----PSTETPLDFDDMEVKLGELES*LTEV 497
           EM RKLR+ + ++ K   Q+P +     P    P +  D+E    +LE+ L EV
Sbjct: 72  EMERKLRYLEREIKKD--QIPMLDTGENPDAPLPREMIDLEATFEKLENELREV 123

>VPP4_MOUSE (Q920R6) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 4 (V-ATPase 116-kDa isoform a4) (Vacuolar proton
           translocating ATPase 116 kDa subunit a kidney isoform)
          Length = 833

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 44/109 (40%), Positives = 65/109 (59%), Gaps = 2/109 (1%)
 Frame = +3

Query: 183 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 362
           + RSE M L QV +  E+A+  V+ LG+LGL+QFKDLNA+ + FQR +  +++RC  + R
Sbjct: 4   VFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCESLER 63

Query: 363 KLRFFKEQMSKAGIQVPPMPSTETPL--DFDDMEVKLGELES*LTEVMQ 503
            LRF +++M    +   P    ETPL  +   +E  L +LE  L E  Q
Sbjct: 64  ILRFLEDEMQNEILIQVPEKDAETPLPREMITLETTLEKLEGELQEANQ 112

>VPP3_HUMAN (Q13488) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 3 (V-ATPase 116-kDa isoform a3) (Osteoclastic
           proton pump 116 kDa subunit) (OC-116 kDa) (OC116)
           (T-cell immune regulator 1) (T cell immune response
           cDNA7 protein) (TIRC7)
          Length = 830

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 33/78 (42%), Positives = 54/78 (69%)
 Frame = +3

Query: 183 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 362
           + RSE + L+Q+ +PT +A+  VS LG+LGL++F+DLNA  S FQR +   + RC E+ +
Sbjct: 4   MFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVWRCEELEK 63

Query: 363 KLRFFKEQMSKAGIQVPP 416
              F +E++ +AG+ +PP
Sbjct: 64  TFTFLQEEVRRAGLVLPP 81

>VPP4_HUMAN (Q9HBG4) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 4 (V-ATPase 116-kDa isoform a4) (Vacuolar proton
           translocating ATPase 116 kDa subunit a kidney isoform)
          Length = 840

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 40/109 (36%), Positives = 63/109 (57%), Gaps = 2/109 (1%)
 Frame = +3

Query: 183 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 362
           + RSE M L Q+ +  E+A+  V+ LG+LGL+QFKDLN + + FQR +  +++RC  + R
Sbjct: 4   VFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLER 63

Query: 363 KLRFFKEQMSKAGI--QVPPMPSTETPLDFDDMEVKLGELES*LTEVMQ 503
            LRF +++M    +   +   P T  P +   +E  L +LE  L E  Q
Sbjct: 64  ILRFLEDEMQNEIVVQLLEKSPLTPLPREMITLETVLEKLEGELQEANQ 112

>VPP2_MOUSE (P15920) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 2 (V-ATPase 116-kDa isoform a2) (Immune
           suppressor factor J6B7)
          Length = 856

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 41/111 (36%), Positives = 68/111 (61%), Gaps = 6/111 (5%)
 Frame = +3

Query: 183 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 362
           L RSE+M L Q+ + + +A+  +S LG+ GL+QF+DLN + S FQR +  ++KRC E+ R
Sbjct: 4   LFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELER 63

Query: 363 KLRFFKEQMSKAGIQV------PPMPSTETPLDFDDMEVKLGELES*LTEV 497
            L +  +++++A I +      PP P  +  L   +M+ +L +LE  L EV
Sbjct: 64  ILVYLVQEITRADIPLPEGEASPPAPPLKHVL---EMQEQLQKLEVELREV 111

>VPP2_HUMAN (Q9Y487) Vacuolar proton translocating ATPase 116 kDa subunit a|
           isoform 2 (V-ATPase 116-kDa isoform a2) (TJ6)
          Length = 856

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 41/111 (36%), Positives = 67/111 (60%), Gaps = 6/111 (5%)
 Frame = +3

Query: 183 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 362
           L RSE M L Q+ + + +A+  +S LG+ GL+QF+DLN + S FQR +  ++KRC E+ R
Sbjct: 4   LFRSETMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELER 63

Query: 363 KLRFFKEQMSKAGIQV------PPMPSTETPLDFDDMEVKLGELES*LTEV 497
            L +  +++++A I +      PP P  +  L   +M+ +L +LE  L EV
Sbjct: 64  ILVYLVQEINRADIPLPEGEASPPAPPLKQVL---EMQEQLQKLEVELREV 111

>VPP2_BOVIN (O97681) Vacuolar proton translocating ATPase 116 kDa subunit A|
           isoform 2 (V-ATPase 116-kDa isoform a2)
          Length = 854

 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 40/111 (36%), Positives = 67/111 (60%), Gaps = 6/111 (5%)
 Frame = +3

Query: 183 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 362
           L RSE M L Q+ + + +A+  +S LG+ GL++F+DLN + S FQR +  ++KRC E+ R
Sbjct: 4   LFRSETMCLAQLFLQSGTAYECLSVLGEKGLVEFRDLNQNVSSFQRKFVGEVKRCEELER 63

Query: 363 KLRFFKEQMSKAGIQV------PPMPSTETPLDFDDMEVKLGELES*LTEV 497
            L +  +++++A I +      PP P  +  L   +M+ +L +LE  L EV
Sbjct: 64  ILAYLVQEINRADIPLPEGDTSPPAPPLKQVL---EMQEQLQKLEVELREV 111

>VPH1_NEUCR (Q01290) Vacuolar ATP synthase 98 kDa subunit (Vacuolar ATPase 98|
           kDa subunit)
          Length = 856

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 31/72 (43%), Positives = 45/72 (62%)
 Frame = +3

Query: 189 RSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSRKL 368
           RS  M ++Q+ I  E      + LG+LGL+ F+DLN++ S FQR +   I+R   + R+L
Sbjct: 10  RSADMSMVQLYISNEIGREVCNALGELGLVHFRDLNSELSAFQRAFTQDIRRLDNVERQL 69

Query: 369 RFFKEQMSKAGI 404
           R+F  QM KAGI
Sbjct: 70  RYFHSQMEKAGI 81

>VPH1_YEAST (P32563) Vacuolar ATP synthase subunit a, vacuolar isoform (EC|
           3.6.3.14) (V-ATPase a subunit) (Vacuolar proton pump a
           subunit) (V-ATPase 95 kDa subunit) (Vacuolar pH protein
           1)
          Length = 839

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 29/76 (38%), Positives = 45/76 (59%)
 Frame = +3

Query: 183 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 362
           + RS  M L+Q  IP E +  +   LG LGL+QF+DLN+    FQRT+  +I+R   + R
Sbjct: 7   IFRSAEMALVQFYIPQEISRDSAYTLGQLGLVQFRDLNSKVRAFQRTFVNEIRRLDNVER 66

Query: 363 KLRFFKEQMSKAGIQV 410
           + R+F   + K  I++
Sbjct: 67  QYRYFYSLLKKHDIKL 82

>VPH1_SCHPO (O13742) Probable vacuolar ATP synthase 91 kDa subunit (Vacuolar|
           ATPase 91 kDa subunit)
          Length = 805

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 30/91 (32%), Positives = 52/91 (57%), Gaps = 6/91 (6%)
 Frame = +3

Query: 249 VSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSRKLRFFKEQMSKAGIQVPP---M 419
           +S LG+L  I FKDLN D   FQR++  +I+R  +  R LR+   ++   GI VP     
Sbjct: 1   MSALGELSTIHFKDLNPDVVAFQRSFVREIRRLTDTERLLRYLHSEIDLNGIHVPDHNLP 60

Query: 420 PSTETPLD---FDDMEVKLGELES*LTEVMQ 503
           PS E+ L+    +D+  ++  LE+ + ++++
Sbjct: 61  PSYESVLESSTIEDIIERITRLEARVRQLVE 91

>STV1_YEAST (P37296) Vacuolar ATP synthase subunit a, Golgi isoform (EC|
           3.6.3.14) (V-ATPase 101 kDa subunit) (V-ATPase subunit
           AC115) (Similar to VPH1 protein 1)
          Length = 890

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 24/71 (33%), Positives = 35/71 (49%)
 Frame = +3

Query: 183 LMRSEAMQLLQVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSR 362
           + RS  M  +Q+ IP E        LG + +    DLN D + FQR Y  Q++R  E+ R
Sbjct: 7   IFRSADMTYVQLYIPLEVIREVTFLLGKMSVFMVMDLNKDLTAFQRGYVNQLRRFDEVER 66

Query: 363 KLRFFKEQMSK 395
            + F  E + K
Sbjct: 67  MVGFLNEVVEK 77

>FLCN_BOVIN (Q3B7L5) Folliculin|
          Length = 579

 Score = 30.4 bits (67), Expect = 3.1
 Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 3/57 (5%)
 Frame = -2

Query: 311 RAFVCVEVFELDEAQIAEVGDGEVRGLGGDND---LQELHRLRPHQIHRGAAAPSAA 150
           R   C EV      Q A  GDG  RG   D +   +Q   R+R H    GA+A S++
Sbjct: 17  RTLFCTEVLHAPLPQGAGSGDGAGRGEPADEEEGGIQMSSRIRAHSPAEGASAESSS 73

>ARHG2_MOUSE (Q60875) Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid|
           blast crisis-like 1) (LBC'S first cousin) (Oncogene LFC)
           (RHOBIN)
          Length = 596

 Score = 30.4 bits (67), Expect = 3.1
 Identities = 16/57 (28%), Positives = 32/57 (56%)
 Frame = +3

Query: 213 QVIIPTESAHLAVSHLGDLGLIQFKDLNADKSPFQRTYAAQIKRCAEMSRKLRFFKE 383
           Q + P  + +  +  LGDL + QF   NA++   ++TY+   + C+  ++ L+ +KE
Sbjct: 304 QALCPGSTRNFVIHRLGDLLISQFSGSNAEQ--MRKTYS---EFCSRHTKALKLYKE 355

>SYS_METMA (Q8PYJ6) Seryl-tRNA synthetase (EC 6.1.1.11) (Serine--tRNA ligase)|
           (SerRS)
          Length = 422

 Score = 29.3 bits (64), Expect = 6.9
 Identities = 15/60 (25%), Positives = 29/60 (48%)
 Frame = +3

Query: 273 LIQFKDLNADKSPFQRTYAAQIKRCAEMSRKLRFFKEQMSKAGIQVPPMPSTETPLDFDD 452
           + Q K  N D +           R  E+  K+R +K ++++  + +P +PS  TP+  D+
Sbjct: 59  IAQLKKENKDAASRINEMQGINSRIKELDDKIRDYKSKINEIMLSIPNIPSETTPVGKDE 118

>PCSK9_RAT (P59996) Proprotein convertase subtilisin/kexin type 9 precursor|
           (EC 3.4.21.-) (Proprotein convertase PC9)
           (Subtilisin/kexin-like protease PC9) (Neural
           apoptosis-regulated convertase 1) (NARC-1)
          Length = 691

 Score = 29.3 bits (64), Expect = 6.9
 Identities = 16/34 (47%), Positives = 20/34 (58%), Gaps = 5/34 (14%)
 Frame = -3

Query: 250 TARCADSVGIMTCRSCIAS-----DRIRSIGGQQ 164
           TARCA    +++C S   S     DRI +IGGQQ
Sbjct: 473 TARCAPEEELLSCSSFSRSGRRRGDRIEAIGGQQ 506


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,469,744
Number of Sequences: 219361
Number of extensions: 1032944
Number of successful extensions: 3075
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 3018
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3073
length of database: 80,573,946
effective HSP length: 104
effective length of database: 57,760,402
effective search space used: 3985467738
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)