>VILI2_ARATH (O81644) Villin-2|
Length = 976
Score = 213 bits (543), Expect = 1e-55
Identities = 96/146 (65%), Positives = 123/146 (84%)
Frame = +1
Query: 1 LKEKYHGGVCDVAIVDDGKLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYS 180
LK+KYH G CDVAIVDDGKL ESDSG FWVLFGGFAPIG+K +DDD+V E+T PKLY
Sbjct: 197 LKDKYHEGTCDVAIVDDGKLDTESDSGAFWVLFGGFAPIGRKVANDDDIVPESTPPKLYC 256
Query: 181 INGGELKFEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQK 360
I G+++ D L+K++LENT+C+LLDCGAE+++WVGRVTQ+++RKAA+++ EEF+ ++
Sbjct: 257 ITDGKMEPIDGDLSKSMLENTKCYLLDCGAEIYIWVGRVTQVDERKAASQSAEEFLASEN 316
Query: 361 RPKTTRVTQVIQGYESHSLKSKFESW 438
RPK T VT+VIQGYESHS KS F+SW
Sbjct: 317 RPKATHVTRVIQGYESHSFKSNFDSW 342
Score = 37.4 bits (85), Expect = 0.016
Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Frame = +1
Query: 91 VLFGGFAPIGKKTVSDDDVVLETTAPK---LYSINGGEL---KFEDIPLTKAVLENTRCF 252
VL GG + K ++ + + ET P+ L ++G + K + L + CF
Sbjct: 490 VLKGGLSSGYKSSMGESESTDETYTPESIALVQVSGTGVHNNKAVQVETVATSLNSYECF 549
Query: 253 LLDCGAEMFVWVGRVTQLEDRKAATKAIE 339
LL G MF+W G + E + ATK E
Sbjct: 550 LLQSGTSMFLWHGNQSTHEQLELATKVAE 578
Score = 37.0 bits (84), Expect = 0.021
Identities = 25/96 (26%), Positives = 46/96 (47%), Gaps = 3/96 (3%)
Frame = +1
Query: 70 SDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSI--NGGELKFEDI-PLTKAVLEN 240
++S FW GG K S + + P L+S N G+ + E+I + L
Sbjct: 593 TESSTFWFALGGKQNFTSKKASSETI----RDPHLFSFAFNRGKFQVEEIYNFAQDDLLT 648
Query: 241 TRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFI 348
+ LD AE+FVWVG+ + ++++ + +++I
Sbjct: 649 EDIYFLDTHAEVFVWVGQCVEPKEKQTVFEIGQKYI 684
>VILI3_ARATH (O81645) Villin-3|
Length = 966
Score = 206 bits (524), Expect = 2e-53
Identities = 92/146 (63%), Positives = 120/146 (82%)
Frame = +1
Query: 1 LKEKYHGGVCDVAIVDDGKLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYS 180
LK+K+H G DVAIVDDGKL ESDSGEFWVLFGGFAPI +K S+D+++ ETT PKLYS
Sbjct: 199 LKDKFHEGTSDVAIVDDGKLDTESDSGEFWVLFGGFAPIARKVASEDEIIPETTPPKLYS 258
Query: 181 INGGELKFEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQK 360
I G+++ D L+K++LEN +C+LLDCG+E+F+WVGRVTQ+E+RK A +A E+F+ ++
Sbjct: 259 IADGQVESIDGDLSKSMLENNKCYLLDCGSEIFIWVGRVTQVEERKTAIQAAEDFVASEN 318
Query: 361 RPKTTRVTQVIQGYESHSLKSKFESW 438
RPK TR+T+VIQGYE HS KS F+SW
Sbjct: 319 RPKATRITRVIQGYEPHSFKSNFDSW 344
Score = 40.0 bits (92), Expect = 0.003
Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 3/96 (3%)
Frame = +1
Query: 70 SDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSI--NGGELKFEDIP-LTKAVLEN 240
++S FW GG K VS + V P L+S N G+ + E+I + L
Sbjct: 595 TESSSFWFALGGKQNFTSKKVSSETV----RDPHLFSFSFNRGKFQVEEIHNFDQDDLLT 650
Query: 241 TRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFI 348
LLD AE+FVWVG+ ++++ A + + +I
Sbjct: 651 EEMHLLDTHAEVFVWVGQCVDPKEKQTAFEIGQRYI 686
Score = 38.1 bits (87), Expect = 0.010
Identities = 35/114 (30%), Positives = 55/114 (48%), Gaps = 6/114 (5%)
Frame = +1
Query: 91 VLFGGFAPIGKKTVSDDDVVLETTAPK---LYSINGGELKFEDIPLTKAV---LENTRCF 252
VL GG + K ++++ ET P+ L ++G + +AV L + CF
Sbjct: 492 VLKGGLSSGYKNSMTEKGSSGETYTPESIALIQVSGTGVHNNKALQVEAVATSLNSYDCF 551
Query: 253 LLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHS 414
LL G MF+WVG + E ++ A K + EF+ +P TT + +G ES S
Sbjct: 552 LLQSGTSMFLWVGNHSTHEQQELAAK-VAEFL----KPGTT-IKHAKEGTESSS 599
>VILI4_ARATH (O65570) Villin-4|
Length = 974
Score = 151 bits (382), Expect = 6e-37
Identities = 68/147 (46%), Positives = 104/147 (70%), Gaps = 1/147 (0%)
Frame = +1
Query: 1 LKEKYHGGVCDVAIVDDGKLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYS 180
+K+ YH G C+VA V+DGKL A++DSGEFW FGGFAP+ +KT +D+D + +L+
Sbjct: 199 IKDTYHDGTCEVATVEDGKLMADADSGEFWGFFGGFAPLPRKTANDEDKTYNSDITRLFC 258
Query: 181 INGGELK-FEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQ 357
+ G+ E L + +L+ +C++LDCG E+FVW+GR T L+DRK A+KA EE I +
Sbjct: 259 VEKGQANPVEGDTLKREMLDTNKCYILDCGIEVFVWMGRTTSLDDRKIASKAAEEMIRSS 318
Query: 358 KRPKTTRVTQVIQGYESHSLKSKFESW 438
+RPK +++ ++I+G+E+ +SKFESW
Sbjct: 319 ERPK-SQMIRIIEGFETVPFRSKFESW 344
Score = 42.0 bits (97), Expect = 7e-04
Identities = 35/140 (25%), Positives = 61/140 (43%), Gaps = 17/140 (12%)
Frame = +1
Query: 70 SDSGEFWVLFGGFAPIGKKTVSDDDV-------------VLETTAPKLYSINGGELKFED 210
S+S +FW L GG A + ++ + VL+ T ++Y+ +L ED
Sbjct: 594 SESEQFWELLGGKAEYSSQKLTKEPERDPHLFSCTFTKEVLKVT--EIYNFTQDDLMTED 651
Query: 211 IPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFI----INQKRPKTTR 378
I F++DC +E+FVWVG+ +++ A E+FI + +K
Sbjct: 652 I------------FIIDCHSEIFVWVGQEVVPKNKLLALTIGEKFIEKDSLLEKLSPEAP 699
Query: 379 VTQVIQGYESHSLKSKFESW 438
+ +++G E F SW
Sbjct: 700 IYVIMEGGEPSFFTRFFTSW 719
Score = 29.3 bits (64), Expect = 4.4
Identities = 25/123 (20%), Positives = 53/123 (43%), Gaps = 6/123 (4%)
Frame = +1
Query: 85 FWVLFGGFAPIGKKTVSD---DDVVLETTAPKLYSINGG---ELKFEDIPLTKAVLENTR 246
F V GG + KK +++ DD L+ I G ++ + A L ++
Sbjct: 489 FIVFKGGISSGYKKYIAEKEVDDDTYNENGVALFRIQGSGPENMQAIQVDPVAASLNSSY 548
Query: 247 CFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHSLKSK 426
++L + +F W G ++ D++ A + ++ NQ+ ++ Q +E K++
Sbjct: 549 YYILHNDSSVFTWAGNLSTATDQELAERQLDLIKPNQQSRAQKEGSESEQFWELLGGKAE 608
Query: 427 FES 435
+ S
Sbjct: 609 YSS 611
>VILI1_ARATH (O81643) Villin-1|
Length = 910
Score = 113 bits (283), Expect = 2e-25
Identities = 56/148 (37%), Positives = 86/148 (58%), Gaps = 2/148 (1%)
Frame = +1
Query: 1 LKEKYHGGVCDVAIVDDGKLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYS 180
+K+ H G C+VA ++DGK +SD+GEFW FGG+API K + S +T +L+
Sbjct: 198 IKDNKHDGRCEVATIEDGKFSGDSDAGEFWSFFGGYAPIPKLSSSTTQEQTQTPCAELFW 257
Query: 181 IN--GGELKFEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIIN 354
I+ G L K +LE +C++LDC +E+FVW+GR T L +RK + + EEF+
Sbjct: 258 IDTKGNLHPTGTSSLDKDMLEKNKCYMLDCHSEVFVWMGRNTSLTERKTSISSSEEFLRK 317
Query: 355 QKRPKTTRVTQVIQGYESHSLKSKFESW 438
+ R TT + + +G E+ +S F W
Sbjct: 318 EGRSTTTSLVLLTEGLENARFRSFFNKW 345
Score = 39.3 bits (90), Expect = 0.004
Identities = 33/128 (25%), Positives = 60/128 (46%), Gaps = 7/128 (5%)
Frame = +1
Query: 70 SDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLY--SINGGELKFEDI-PLTKAVLEN 240
+++ FW L GG + K + ++ + P L+ S + LK ++I + L
Sbjct: 592 NETDTFWNLLGGKSEYPK----EKEMRKQIEEPHLFTCSCSSDVLKVKEIYNFVQDDLTT 647
Query: 241 TRCFLLDCGAEMFVWVGRVTQLEDRKAA----TKAIEEFIINQKRPKTTRVTQVIQGYES 408
FLLDC +E++VW+G + ++ ++ A K +E I+ + T V V +G+E
Sbjct: 648 EDVFLLDCQSEVYVWIGSNSNIKSKEEALTLGLKFLEMDILEEGLTMRTPVYVVTEGHEP 707
Query: 409 HSLKSKFE 432
FE
Sbjct: 708 PFFTRFFE 715
Score = 28.5 bits (62), Expect = 7.6
Identities = 14/68 (20%), Positives = 35/68 (51%)
Frame = +1
Query: 196 LKFEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQKRPKTT 375
++ +++P ++ L + F+LD +++F++ G + ++ KA + E+I + K
Sbjct: 149 VRVKEVPFLRSSLNHDDVFILDTASKVFLFAGCNSSTQE-KAKAMEVVEYIKDNKHDGRC 207
Query: 376 RVTQVIQG 399
V + G
Sbjct: 208 EVATIEDG 215
>GELS_DROME (Q07171) Gelsolin precursor|
Length = 798
Score = 82.4 bits (202), Expect = 4e-16
Identities = 53/157 (33%), Positives = 89/157 (56%), Gaps = 11/157 (7%)
Frame = +1
Query: 1 LKEKYHGGVCDVAIVDDGKLQAESDSGEFWVLFGGFAP--IGKKTVSDDDVVLETT---A 165
++++ H G V IVDD ++D F+ + G + + ++ +D+D E T A
Sbjct: 252 IRDQDHNGRARVQIVDD--FSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAA 309
Query: 166 PKLYSIN--GGELKFEDI---PLTKAVLENTRCFLLDCGAEMFVWVGR-VTQLEDRKAAT 327
LY ++ G+LK + I PLT+A+L+ CF+LD G+ +FVWVG+ TQ E A
Sbjct: 310 VSLYKVSDASGKLKVDIIGQKPLTQAMLDTRECFILDTGSGIFVWVGKGATQKEKTDAMA 369
Query: 328 KAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
KA +EF+ +K P T++ ++++G ES K F++W
Sbjct: 370 KA-QEFLRTKKYPAWTQIHRIVEGSESAPFKQYFDTW 405
Score = 42.4 bits (98), Expect = 5e-04
Identities = 34/132 (25%), Positives = 60/132 (45%), Gaps = 4/132 (3%)
Frame = +1
Query: 55 KLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSINGGELKFEDIP-LTKAV 231
+++ ++ EFW G + D +LE+ + +GG LK E++ +
Sbjct: 642 QVEEGAEPDEFWEELNGEGQYDRSLGDDGAPLLESRLFHCHLSSGGFLKVEEVAQYEQED 701
Query: 232 LENTRCFLLDCGAEMFVWVG-RVTQLEDRKAATKAIEEFII--NQKRPKTTRVTQVIQGY 402
L++ LLD G E+++WVG V++ E+ K A F + + T + +V QG
Sbjct: 702 LDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYFNLEPTARSFDTVSIIRVPQGK 761
Query: 403 ESHSLKSKFESW 438
E K F +W
Sbjct: 762 EPRVFKRMFPNW 773
Score = 32.3 bits (72), Expect = 0.52
Identities = 20/88 (22%), Positives = 45/88 (51%), Gaps = 1/88 (1%)
Frame = +1
Query: 169 KLYSINGGE-LKFEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEF 345
+L+ + G ++ + L+ + + CF+LD G++++V+VG + ++ A A +
Sbjct: 193 RLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQ- 251
Query: 346 IINQKRPKTTRVTQVIQGYESHSLKSKF 429
I +Q RV Q++ + + + K F
Sbjct: 252 IRDQDHNGRARV-QIVDDFSTDADKQHF 278
>GELS_HUMAN (P06396) Gelsolin precursor (Actin-depolymerizing factor) (ADF)|
(Brevin) (AGEL)
Length = 782
Score = 63.2 bits (152), Expect = 3e-10
Identities = 37/117 (31%), Positives = 60/117 (51%), Gaps = 8/117 (6%)
Frame = +1
Query: 112 PIGKKTVSDDDVVLETTAPKLYSINGG------ELKFEDIPLTKAVLENTRCFLLDCGAE 273
P G + + +D A KLY ++ G L ++ P + L++ CF+LD G +
Sbjct: 281 PAGTEDTAKEDAANRKLA-KLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKD 339
Query: 274 --MFVWVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
+FVW G+ E+RKAA K +FI PK T+V+ + +G E+ K F++W
Sbjct: 340 GKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNW 396
Score = 48.1 bits (113), Expect = 9e-06
Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 6/129 (4%)
Frame = +1
Query: 70 SDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSING--GELKFEDIP--LTKAVLE 237
S+ FW GG A + + D ++ P+L++ + G E++P L + L
Sbjct: 636 SEPDGFWEALGGKAAY-RTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLA 694
Query: 238 NTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQ--KRPKTTRVTQVIQGYESH 411
LLD ++FVWVG+ +Q E++ A + + +I R + T +T V QG+E
Sbjct: 695 TDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPP 754
Query: 412 SLKSKFESW 438
S F W
Sbjct: 755 SFVGWFLGW 763
Score = 35.0 bits (79), Expect = 0.081
Identities = 28/107 (26%), Positives = 53/107 (49%), Gaps = 1/107 (0%)
Frame = +1
Query: 100 GGFAPIGKKTVSDDDVVLETTAPKLYSINGGEL-KFEDIPLTKAVLENTRCFLLDCGAEM 276
GG A G K V ++VV++ +L+ + G + + ++P++ N CF+LD G +
Sbjct: 170 GGVAS-GFKHVVPNEVVVQ----RLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNI 224
Query: 277 FVWVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHSL 417
W G + +R AT+ + + I + +R RV +G E ++
Sbjct: 225 HQWCGSNSNRYERLKATQ-VSKGIRDNERSGRARVHVSEEGTEPEAM 270
>GELS_MOUSE (P13020) Gelsolin precursor (Actin-depolymerizing factor) (ADF)|
(Brevin)
Length = 780
Score = 62.4 bits (150), Expect = 5e-10
Identities = 36/117 (30%), Positives = 61/117 (52%), Gaps = 8/117 (6%)
Frame = +1
Query: 112 PIGKKTVSDDDVVLETTAPKLYSINGG------ELKFEDIPLTKAVLENTRCFLLDCGAE 273
P G + + +D A KLY ++ G L ++ P + L + CF+LD G +
Sbjct: 279 PEGTEDTAKEDAANRRLA-KLYKVSNGAGSMSVSLVADENPFAQGALRSEDCFILDHGRD 337
Query: 274 --MFVWVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
+FVW G+ +E+RKAA K +FI + P+ T+V+ + +G E+ K F++W
Sbjct: 338 GKIFVWKGKQANMEERKAALKTASDFISKMQYPRQTQVSVLPEGGETPLFKQFFKNW 394
Score = 47.4 bits (111), Expect = 2e-05
Identities = 35/134 (26%), Positives = 62/134 (46%), Gaps = 6/134 (4%)
Frame = +1
Query: 55 KLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSING--GELKFEDIP--LT 222
+++ S+ FW GG + + D ++ P+L++ + G E++P L
Sbjct: 629 QVEEGSEPDAFWEALGGKTAY-RTSPRLKDKKMDAHPPRLFACSNRIGRFVIEEVPGELM 687
Query: 223 KAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQ--KRPKTTRVTQVIQ 396
+ L LLD ++FVWVG+ +Q E++ A + + +I R + T +T V Q
Sbjct: 688 QEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVRQ 747
Query: 397 GYESHSLKSKFESW 438
G+E S F W
Sbjct: 748 GFEPPSFVGWFLGW 761
Score = 33.9 bits (76), Expect = 0.18
Identities = 23/88 (26%), Positives = 45/88 (51%), Gaps = 1/88 (1%)
Frame = +1
Query: 100 GGFAPIGKKTVSDDDVVLETTAPKLYSINGGEL-KFEDIPLTKAVLENTRCFLLDCGAEM 276
GG A G K V ++VV++ +L+ + G + + ++P++ N CF+LD G +
Sbjct: 168 GGVAS-GFKHVVPNEVVVQ----RLFQVKGRRVVRATEVPVSWDSFNNGDCFILDLGNNI 222
Query: 277 FVWVGRVTQLEDRKAATKAIEEFIINQK 360
+ W G + +R AT+ + N++
Sbjct: 223 YQWCGSGSNKFERLKATQVSKGIRDNER 250
>GELS_PIG (P20305) Gelsolin precursor (Actin-depolymerizing factor) (ADF)|
(Brevin) (Fragment)
Length = 772
Score = 61.6 bits (148), Expect = 8e-10
Identities = 37/112 (33%), Positives = 58/112 (51%), Gaps = 12/112 (10%)
Frame = +1
Query: 139 DDVVLETTA----PKLYSINGG------ELKFEDIPLTKAVLENTRCFLLDCGAE--MFV 282
+D V E A KLY ++ G L ++ P + L++ CF+LD G + +FV
Sbjct: 275 EDTVKEDAANRKLAKLYKVSNGAGTMTVSLVADENPFAQGALKSEDCFILDHGKDGKIFV 334
Query: 283 WVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
W G+ E+RKAA K +FI PK T+V+ + +G E+ K F++W
Sbjct: 335 WKGKQANTEERKAALKTASDFISKMNYPKQTQVSVLPEGGETPLFKQFFKNW 386
Score = 46.6 bits (109), Expect = 3e-05
Identities = 35/129 (27%), Positives = 59/129 (45%), Gaps = 6/129 (4%)
Frame = +1
Query: 70 SDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSING--GELKFEDIP--LTKAVLE 237
S+ FW GG A + + D ++ P+L++ + G E++P L + L
Sbjct: 626 SEPDSFWEALGGKAAY-RTSPRLKDKKMDAHPPRLFACSNKIGRFVVEEVPGELMQEDLA 684
Query: 238 NTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQ--KRPKTTRVTQVIQGYESH 411
LLD ++FVWVG+ +Q E++ A + + +I R + T + V QG+E
Sbjct: 685 TDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPINVVKQGFEPP 744
Query: 412 SLKSKFESW 438
S F W
Sbjct: 745 SFVGWFLGW 753
Score = 31.6 bits (70), Expect = 0.89
Identities = 15/70 (21%), Positives = 34/70 (48%), Gaps = 1/70 (1%)
Frame = +1
Query: 154 ETTAPKLYSINGGEL-KFEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATK 330
E +L+ + G + + ++P++ CF+LD G +++ W G + +R AT+
Sbjct: 173 EVAVQRLFQVKGRRVVRATEVPVSWESFNRGDCFILDLGNDIYQWCGSNSNRYERLKATQ 232
Query: 331 AIEEFIINQK 360
+ N++
Sbjct: 233 VSKGIRDNER 242
>GELS_HORSE (Q28372) Gelsolin (Actin-depolymerizing factor) (ADF) (Brevin)|
Length = 730
Score = 60.8 bits (146), Expect = 1e-09
Identities = 36/112 (32%), Positives = 58/112 (51%), Gaps = 12/112 (10%)
Frame = +1
Query: 139 DDVVLETTA----PKLYSINGG------ELKFEDIPLTKAVLENTRCFLLDCGAE--MFV 282
+D V E A KLY ++ G L ++ P + L + CF+LD G + +FV
Sbjct: 233 EDTVKEDAANRKLAKLYKVSNGAGPMVVSLVADENPFAQGALRSEDCFILDHGKDGKIFV 292
Query: 283 WVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
W G+ +E+RKAA K +FI PK T+V+ + +G E+ + F++W
Sbjct: 293 WKGKQANMEERKAALKTASDFISKMDYPKQTQVSVLPEGGETPLFRQFFKNW 344
Score = 46.6 bits (109), Expect = 3e-05
Identities = 35/129 (27%), Positives = 59/129 (45%), Gaps = 6/129 (4%)
Frame = +1
Query: 70 SDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSING--GELKFEDIP--LTKAVLE 237
S+ FW GG A + + D ++ P+L++ + G E++P + L
Sbjct: 584 SEPDSFWEALGGKATY-RTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGEFMQEDLA 642
Query: 238 NTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQ--KRPKTTRVTQVIQGYESH 411
LLD ++FVWVG+ +Q E++ A + + +I R + T +T V QG+E
Sbjct: 643 TDDVMLLDTWDQVFVWVGKDSQDEEKTEALTSAKRYIDTDPAHRDRRTPITVVKQGFEPP 702
Query: 412 SLKSKFESW 438
S F W
Sbjct: 703 SFVGWFLGW 711
Score = 35.0 bits (79), Expect = 0.081
Identities = 27/107 (25%), Positives = 54/107 (50%), Gaps = 1/107 (0%)
Frame = +1
Query: 100 GGFAPIGKKTVSDDDVVLETTAPKLYSINGGEL-KFEDIPLTKAVLENTRCFLLDCGAEM 276
GG A G K V ++VV++ +L + G + + ++P++ N CF+LD G +
Sbjct: 118 GGVAS-GFKHVVPNEVVVQ----RLLQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNI 172
Query: 277 FVWVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHSL 417
+ W G + +R AT+ + + I + +R +V+ +G E ++
Sbjct: 173 YQWCGSKSNRFERLKATQ-VSKGIRDNERSGRAQVSVFEEGAEPEAM 218
>ADSV_HUMAN (Q9Y6U3) Adseverin (Scinderin)|
Length = 715
Score = 60.1 bits (144), Expect = 2e-09
Identities = 36/112 (32%), Positives = 61/112 (54%), Gaps = 11/112 (9%)
Frame = +1
Query: 136 DDDVVLETT---APKLYSIN--GGELKF----EDIPLTKAVLENTRCFLLDCGA--EMFV 282
DDD++ + + KLY ++ G ++ E+ P + A+L + CF+LD GA ++FV
Sbjct: 236 DDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFV 295
Query: 283 WVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
W G+ ++RKAA K EEF+ K T++ + +G E+ K F+ W
Sbjct: 296 WKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDW 347
Score = 45.4 bits (106), Expect = 6e-05
Identities = 36/138 (26%), Positives = 60/138 (43%), Gaps = 10/138 (7%)
Frame = +1
Query: 55 KLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETTA----PKLYSING--GELKFEDIP 216
++Q + EFW GG K +LET A P+LY + G E+IP
Sbjct: 579 RIQEGEEPEEFWNSLGG------KKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIP 632
Query: 217 --LTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQK--RPKTTRVT 384
T+ L LLD ++F+W+G+ ++K + K+ + ++ R K T +
Sbjct: 633 GEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIV 692
Query: 385 QVIQGYESHSLKSKFESW 438
+ QG+E + F W
Sbjct: 693 IIKQGHEPPTFTGWFLGW 710
Score = 33.5 bits (75), Expect = 0.24
Identities = 20/89 (22%), Positives = 41/89 (46%), Gaps = 1/89 (1%)
Frame = +1
Query: 154 ETTAPKLYSINGGEL-KFEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATK 330
+ TA +L + G + + ++PL+ CF++D G E++ W G +R A +
Sbjct: 133 DLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQ 192
Query: 331 AIEEFIINQKRPKTTRVTQVIQGYESHSL 417
N+++ ++ + V +G E L
Sbjct: 193 VATGIRYNERKGRSELIV-VEEGSEPSEL 220
>ADSV_MOUSE (Q60604) Adseverin (Scinderin) (Gelsolin-like protein)|
Length = 715
Score = 58.9 bits (141), Expect = 5e-09
Identities = 37/113 (32%), Positives = 60/113 (53%), Gaps = 11/113 (9%)
Frame = +1
Query: 133 SDDDVVLETT---APKLYSIN--GGELKF----EDIPLTKAVLENTRCFLLDCGA--EMF 279
+DDDVV + + KLY ++ G +K E+ P + +L + CF+LD GA ++F
Sbjct: 235 NDDDVVADISNRKMAKLYMVSDASGSMKVTLVAEENPFSMGMLLSEECFILDHGAAKQIF 294
Query: 280 VWVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
VW G+ ++RK A K EEF+ K T++ + +G E+ K F+ W
Sbjct: 295 VWKGKNANPQERKTAMKTAEEFLQKMKYSTNTQIQVLPEGGETPIFKQFFKDW 347
Score = 46.2 bits (108), Expect = 4e-05
Identities = 39/155 (25%), Positives = 65/155 (41%), Gaps = 10/155 (6%)
Frame = +1
Query: 4 KEKYHGGVCDVAIVDDGKLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETTA----PK 171
+EK V DV ++Q + EFW GG +LET A P+
Sbjct: 562 EEKGAEYVADVLKCKASRIQEGKEPEEFWNSLGGRGDY------QTSPLLETRAEDHPPR 615
Query: 172 LYSING--GELKFEDIP--LTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIE 339
LY + G E++P T+ L LLD ++F+W+G+ ++K + K+ +
Sbjct: 616 LYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESVKSAK 675
Query: 340 EFIINQK--RPKTTRVTQVIQGYESHSLKSKFESW 438
++ R K T + + QG+E + F W
Sbjct: 676 MYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 710
Score = 32.7 bits (73), Expect = 0.40
Identities = 24/90 (26%), Positives = 44/90 (48%), Gaps = 2/90 (2%)
Frame = +1
Query: 154 ETTAPKLYSINGGEL-KFEDIPLTKAVLENTRCFLLDCGAEMFVWVG-RVTQLEDRKAAT 327
+ TA +L + G + + ++PL+ CF++D G E++ W G + E KA+
Sbjct: 133 DLTAKRLLHVKGRRVVRATEVPLSWESFNKGDCFIIDLGTEIYQWCGSSCNKYERLKASQ 192
Query: 328 KAIEEFIINQKRPKTTRVTQVIQGYESHSL 417
AI I + +R +++ V +G E L
Sbjct: 193 VAIG--IRDNERKGRSQLIVVEEGSEPSEL 220
>ADSV_BOVIN (Q28046) Adseverin (Scinderin) (SC)|
Length = 715
Score = 58.9 bits (141), Expect = 5e-09
Identities = 44/157 (28%), Positives = 76/157 (48%), Gaps = 11/157 (7%)
Frame = +1
Query: 1 LKEKYHGGVCDVAIVDDGKLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETT---APK 171
+++ G + +V++G S+ E + G P + DDD+ + T K
Sbjct: 197 IRDNERKGRAQLIVVEEG-----SEPSELTKVLGE-KPKLRDGEDDDDIKADITNRKMAK 250
Query: 172 LYSIN--GGELKF----EDIPLTKAVLENTRCFLLDCGA--EMFVWVGRVTQLEDRKAAT 327
LY ++ G +K E+ P + A+L + CF+LD GA ++FVW G+ ++RKAA
Sbjct: 251 LYMVSDASGSMKVSLVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAM 310
Query: 328 KAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
K EEF+ T++ + +G E+ K F+ W
Sbjct: 311 KTAEEFLQQMNYSTNTQIQVLPEGGETPIFKQFFKDW 347
Score = 42.0 bits (97), Expect = 7e-04
Identities = 32/143 (22%), Positives = 59/143 (41%), Gaps = 6/143 (4%)
Frame = +1
Query: 28 CDVAIVDDGKLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSING--GELK 201
C + + +GK + EFW GG + + E P+LY + G
Sbjct: 575 CKTSTIQEGK-----EPEEFWNSLGGKKDYQTSPLLESQA--EDHPPRLYGCSNKTGRFI 627
Query: 202 FEDIP--LTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQK--RPK 369
E++P T+ L LLD ++F+W+G+ ++ + K+ + ++ R K
Sbjct: 628 IEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKSESLKSAKIYLETDPSGRDK 687
Query: 370 TTRVTQVIQGYESHSLKSKFESW 438
T + + QG+E + F W
Sbjct: 688 RTPIVIIKQGHEPPTFTGWFLGW 710
Score = 32.0 bits (71), Expect = 0.68
Identities = 24/90 (26%), Positives = 43/90 (47%), Gaps = 2/90 (2%)
Frame = +1
Query: 154 ETTAPKLYSINGGEL-KFEDIPLTKAVLENTRCFLLDCGAEMFVWVG-RVTQLEDRKAAT 327
+ TA +L + G + + ++PL+ CF++D G E++ W G + E KA+
Sbjct: 133 DLTAQRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKASQ 192
Query: 328 KAIEEFIINQKRPKTTRVTQVIQGYESHSL 417
AI I + +R ++ V +G E L
Sbjct: 193 VAIG--IRDNERKGRAQLIVVEEGSEPSEL 220
>GELS_CHICK (O93510) Gelsolin precursor (Actin-depolymerizing factor) (ADF)|
(Brevin) (Homogenin)
Length = 778
Score = 57.4 bits (137), Expect = 2e-08
Identities = 36/113 (31%), Positives = 56/113 (49%), Gaps = 11/113 (9%)
Frame = +1
Query: 133 SDDDVVLETT---APKLYSINGG------ELKFEDIPLTKAVLENTRCFLLDCGAE--MF 279
+ DD +T KLY ++ G L ++ P ++A L CF+LD G + +F
Sbjct: 280 ASDDTKTDTANRKLAKLYKVSNGAGNMAVSLVADENPFSQAALNTEDCFILDHGTDGKIF 339
Query: 280 VWVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
VW GR ++RKAA K +FI PK T+V + + E+ K F++W
Sbjct: 340 VWKGRSANSDERKAALKTATDFIDKMGYPKHTQVQVLPESGETPLFKQFFKNW 392
Score = 55.5 bits (132), Expect = 6e-08
Identities = 38/124 (30%), Positives = 60/124 (48%), Gaps = 6/124 (4%)
Frame = +1
Query: 85 FWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSING--GELKFEDIP--LTKAVLENTRCF 252
FWV GG AP + + D ++ P+L++ + G E++P LT+ L
Sbjct: 637 FWVALGGKAPY-RTSPRLKDKKMDAYPPRLFACSNKSGRFTIEEVPGDLTQDDLATDDVM 695
Query: 253 LLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQ--KRPKTTRVTQVIQGYESHSLKSK 426
+LD ++FVW+G+ Q E++ A K+ + +I R K T VT V QG E +
Sbjct: 696 ILDTWDQVFVWIGKDAQEEEKTEALKSAKRYIETDPASRDKRTPVTLVKQGLEPPTFSGW 755
Query: 427 FESW 438
F W
Sbjct: 756 FLGW 759
Score = 33.9 bits (76), Expect = 0.18
Identities = 17/70 (24%), Positives = 34/70 (48%), Gaps = 1/70 (1%)
Frame = +1
Query: 154 ETTAPKLYSINGGE-LKFEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATK 330
E T +L + G ++ ++P++ CF+LD G+ ++ W G + ++R AT
Sbjct: 179 EVTVQRLLQVKGRRTVRATEVPVSWESFNTGDCFILDLGSNIYQWCGSNSNRQERLKATV 238
Query: 331 AIEEFIINQK 360
+ N+K
Sbjct: 239 LAKGIRDNEK 248
>FLII_HUMAN (Q13045) Protein flightless-1 homolog|
Length = 1269
Score = 56.6 bits (135), Expect = 3e-08
Identities = 44/141 (31%), Positives = 68/141 (48%), Gaps = 22/141 (15%)
Frame = +1
Query: 82 EFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSINGG----EL---------------KF 204
EFW GG KK V +D PKLY + G EL K
Sbjct: 701 EFWEALGGEPSEIKKHVPED---FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKV 757
Query: 205 EDIPLTKAV--LENTRC-FLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQKRPKTT 375
E +P + + L +TRC ++LDC +++F+W+GR + R AA K +E RP+
Sbjct: 758 ELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHA 817
Query: 376 RVTQVIQGYESHSLKSKFESW 438
V++ ++G E+ K+KF++W
Sbjct: 818 TVSRSLEGTEAQVFKAKFKNW 838
Score = 40.4 bits (93), Expect = 0.002
Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 1/103 (0%)
Frame = +1
Query: 100 GGFAPIGKKTVSDDDVVLETTAPKLYSINGGE-LKFEDIPLTKAVLENTRCFLLDCGAEM 276
GG A G TV D V ++Y + G + +K E +PL L+ FLLD G ++
Sbjct: 603 GGTAS-GFYTVEDTHYVT-----RMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDI 656
Query: 277 FVWVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYE 405
+VW G L A E+ N+++ K +T ++QG E
Sbjct: 657 YVWRGAQATLSSTTKARLFAEKINKNERKGK-AEITLLVQGQE 698
Score = 37.4 bits (85), Expect = 0.016
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 5/67 (7%)
Frame = +1
Query: 253 LLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQK-----RPKTTRVTQVIQGYESHSL 417
LLD G E+++WVG T + K + KA + +I + + RP+ R+ V +G E H+
Sbjct: 1197 LLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRL--VRKGNEQHAF 1254
Query: 418 KSKFESW 438
F +W
Sbjct: 1255 TRCFHAW 1261
>FLII_MOUSE (Q9JJ28) Protein flightless-1 homolog|
Length = 1271
Score = 55.1 bits (131), Expect = 8e-08
Identities = 39/141 (27%), Positives = 66/141 (46%), Gaps = 23/141 (16%)
Frame = +1
Query: 85 FWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSINGGELKFEDIP---------------- 216
FW + GG K V DD PKLY + G L + ++P
Sbjct: 702 FWDVLGGEPSEIKNHVPDD---FWPPQPKLYKVGLG-LGYLELPQINYKLSVEHKKRPKV 757
Query: 217 -------LTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQKRPKTT 375
L +++L+ ++LDC +++F+W+GR + R AA K +E RP+ T
Sbjct: 758 ELMPGMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHT 817
Query: 376 RVTQVIQGYESHSLKSKFESW 438
V++ ++G E+ K+KF++W
Sbjct: 818 VVSRSLEGTEAQVFKAKFKNW 838
Score = 41.2 bits (95), Expect = 0.001
Identities = 32/103 (31%), Positives = 51/103 (49%), Gaps = 1/103 (0%)
Frame = +1
Query: 100 GGFAPIGKKTVSDDDVVLETTAPKLYSINGGE-LKFEDIPLTKAVLENTRCFLLDCGAEM 276
GG A G TV D V ++Y + G + +K E +PL + L+ FLLD G ++
Sbjct: 603 GGTAS-GFYTVEDTHYVT-----RMYRVYGKKNIKLEPVPLKGSSLDPRFVFLLDQGLDI 656
Query: 277 FVWVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYE 405
+VW G L + A E+ N+++ K +T ++QG E
Sbjct: 657 YVWRGAQATLSNTTKARLFAEKINKNERKGK-AEITLLVQGQE 698
Score = 33.9 bits (76), Expect = 0.18
Identities = 19/65 (29%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Frame = +1
Query: 253 LLDCGAEMFVWVGRVTQLEDRKAATKAIEEFI---INQKRPKTTRVTQVIQGYESHSLKS 423
LLD G E+++WVG T + K + KA + +I +++ + R+ V +G E +
Sbjct: 1199 LLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHTRSKEHERPRRLRLVRKGNEQRAFTR 1258
Query: 424 KFESW 438
F +W
Sbjct: 1259 CFHAW 1263
>VILI_MOUSE (Q62468) Villin-1|
Length = 826
Score = 53.9 bits (128), Expect = 2e-07
Identities = 43/156 (27%), Positives = 75/156 (48%), Gaps = 10/156 (6%)
Frame = +1
Query: 1 LKEKYHGGVCDVAIVDDGKLQAESDSGEFWVLFGG-FAPIGKKTVSDDDVVLETTAP--- 168
++++ GG V +VD K E DS + + P + + D V+E A
Sbjct: 196 IRDQERGGRTYVGVVDGEK---EGDSPQLMAIMNHVLGPRKELKAAISDSVVEPAAKAAL 252
Query: 169 KLYSING--GELKFEDI---PLTKAVLENTRCFLLDCGA-EMFVWVGRVTQLEDRKAATK 330
KLY ++ G+L ++ PLT+ +L++ C++LD G ++FVW G+ ++R A
Sbjct: 253 KLYHVSDSEGKLVVREVATRPLTQDLLKHEDCYILDQGGLKIFVWKGKNANAQERSGAMS 312
Query: 331 AIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
FI ++ P +T+V G ES + F+ W
Sbjct: 313 QALNFIKAKQYPPSTQVEVQNDGAESPIFQQLFQKW 348
Score = 51.6 bits (122), Expect = 8e-07
Identities = 33/125 (26%), Positives = 57/125 (45%), Gaps = 3/125 (2%)
Frame = +1
Query: 73 DSGEFWVLFGGFAPIGK-KTVSDDDVVLETTAPKLYSINGGELKFEDIPLTKAVLENTRC 249
+ FW+ GG AP K + +++ V+ + + G L E + LE
Sbjct: 589 EPANFWMALGGKAPYANTKRLQEENQVITPRLFECSNQTGRFLATEIFDFNQDDLEEEDV 648
Query: 250 FLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQ--KRPKTTRVTQVIQGYESHSLKS 423
FLLD ++F W+G+ E++KAA ++E++ R T + V QG+E +
Sbjct: 649 FLLDVWDQVFFWIGKHANEEEKKAAATTVQEYLKTHPGNRDLETPIIVVKQGHEPPTFTG 708
Query: 424 KFESW 438
F +W
Sbjct: 709 WFLAW 713
>GELS_HOMAM (Q27319) Gelsolin, cytoplasmic (Actin-depolymerizing factor) (ADF)|
Length = 754
Score = 53.5 bits (127), Expect = 2e-07
Identities = 39/155 (25%), Positives = 76/155 (49%), Gaps = 14/155 (9%)
Frame = +1
Query: 16 HGGVCDVAIVDDGKLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSINGGE 195
H G V ++D+ + S++GE GG +P V+D+D ++ +A + +N
Sbjct: 197 HAGKAKVIVIDE--TASGSEAGESSPGLGGGSP---DDVADEDTGVDDSAFERSEVNVVT 251
Query: 196 LK--FED------------IPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKA 333
L FED PL +++L++ CFLLD G ++VW+G + +++ + +
Sbjct: 252 LHHIFEDGDGVIQTNMIGEKPLLQSMLDSGDCFLLDTGVGVYVWIGSGSSKKEKVKSMEL 311
Query: 334 IEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
++ + P T V +V++ E K+ F++W
Sbjct: 312 AAGYMEKKGYPTYTNVQRVVEKAEPAVFKAYFKTW 346
Score = 31.6 bits (70), Expect = 0.89
Identities = 13/56 (23%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Frame = +1
Query: 169 KLYSINGGE-LKFEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKA 333
+L+ + G ++ + + + CF+LDCG++++ ++G ++ DR A +A
Sbjct: 133 RLFHVKGRRNIRIRQVEVGVGSMNKGDCFILDCGSQVYAYMGPSSRKMDRLKAIQA 188
>VILL_HUMAN (O15195) Villin-like protein|
Length = 856
Score = 52.8 bits (125), Expect = 4e-07
Identities = 43/146 (29%), Positives = 68/146 (46%), Gaps = 6/146 (4%)
Frame = +1
Query: 19 GGVCDVAIVDDGKLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSI--NGG 192
GG + +VDD + VL + T S D L+ +LY + G
Sbjct: 202 GGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQKANVRLYHVYEKGK 261
Query: 193 ELKFEDI---PLTKAVLENTRCFLLDCGA-EMFVWVGRVTQLEDRKAATKAIEEFIINQK 360
+L ++ PLT+ +L+ ++LD G +++VW GR++ L++RKAA FI +
Sbjct: 262 DLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAFSRAVGFIQAKG 321
Query: 361 RPKTTRVTQVIQGYESHSLKSKFESW 438
P T V V G ES + K F +W
Sbjct: 322 YPTYTNVEVVNDGAESAAFKQLFRTW 347
Score = 30.4 bits (67), Expect = 2.0
Identities = 30/123 (24%), Positives = 52/123 (42%), Gaps = 5/123 (4%)
Frame = +1
Query: 85 FWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSING--GELKFEDIPL-TKAVLENTRCFL 255
FW GG AP ++V + P+L+ + G L ++ ++ L+ L
Sbjct: 587 FWEALGGRAPYPSNKRLPEEV--PSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIML 644
Query: 256 LDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQK--RPKTTRVTQVIQGYESHSLKSKF 429
LD E+F+W+G + K A +E++ R T + V QG+E + F
Sbjct: 645 LDTWQEIFLWLGEAA--SEWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWF 702
Query: 430 ESW 438
+W
Sbjct: 703 FTW 705
>VILI_DICDI (P36418) Protovillin (100 kDa actin-binding protein)|
Length = 959
Score = 52.0 bits (123), Expect = 6e-07
Identities = 39/148 (26%), Positives = 64/148 (43%), Gaps = 13/148 (8%)
Frame = +1
Query: 34 VAIVDDGKLQAESDSGEFWVLFGGFAP-IGKKTVSDDDVVLETTAP---KLYSING--GE 195
+ ++D+ + D EFW GG + K DD E + KLY + E
Sbjct: 263 IIVMDEN--DTDKDHPEFWKRLGGCKDDVQKAEQGGDDFAYEKKSVEQIKLYQVENLNYE 320
Query: 196 LKFEDIPLTKAVLENTR-----CFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQK 360
+ I V T+ C++LDC E++VW+G+ + + R A + +
Sbjct: 321 VHLHLIDPIGDVYSTTQLNAEFCYILDCETELYVWLGKASANDQRTVAMANAMDLLHEDN 380
Query: 361 RPKTTRVTQVIQGYESHSLKSKFE--SW 438
RP T + ++ QG E+ K KF+ SW
Sbjct: 381 RPSWTPIIKMTQGSENTLFKDKFKKGSW 408
Score = 37.4 bits (85), Expect = 0.016
Identities = 25/89 (28%), Positives = 42/89 (47%), Gaps = 2/89 (2%)
Frame = +1
Query: 178 SINGGELK-FEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIIN 354
S N G K FE ++ L++ +LD ++FVWVG+ + ++ A + E+I+N
Sbjct: 707 SNNSGVFKVFEIHDFSQDDLDSDDVMILDNQKQIFVWVGKESSDTEKLMANETALEYIMN 766
Query: 355 QKRPKTTRVTQVIQ-GYESHSLKSKFESW 438
+ IQ G+E H F +W
Sbjct: 767 APTHRRDDPIFTIQDGFEPHEFTFNFHAW 795
>VILI_HUMAN (P09327) Villin-1|
Length = 826
Score = 51.2 bits (121), Expect = 1e-06
Identities = 35/128 (27%), Positives = 61/128 (47%), Gaps = 6/128 (4%)
Frame = +1
Query: 73 DSGEFWVLFGGFAPIGK-KTVSDDDVVLETTAPKLYSING--GELKFEDIP-LTKAVLEN 240
+ FW+ GG AP K + ++++V+ P+L+ + G +IP + LE
Sbjct: 589 EPANFWMALGGKAPYANTKRLQEENLVI---TPRLFECSNKTGRFLATEIPDFNQDDLEE 645
Query: 241 TRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQK--RPKTTRVTQVIQGYESHS 414
FLLD ++F W+G+ E++KAA +E++ R T + V QG+E +
Sbjct: 646 DDVFLLDVWDQVFFWIGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPT 705
Query: 415 LKSKFESW 438
F +W
Sbjct: 706 FTGWFLAW 713
Score = 46.2 bits (108), Expect = 4e-05
Identities = 32/108 (29%), Positives = 55/108 (50%), Gaps = 9/108 (8%)
Frame = +1
Query: 142 DVVLETT---APKLYSING--GELKFEDI---PLTKAVLENTRCFLLDCGA-EMFVWVGR 294
D V+E A KLY ++ G L ++ PLT+ +L + C++LD G +++VW G+
Sbjct: 241 DTVVEPALKAALKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGLKIYVWKGK 300
Query: 295 VTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
+++K A FI ++ P +T+V G ES + F+ W
Sbjct: 301 KANEQEKKGAMSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKW 348
>VILL_MOUSE (Q91YD6) Villin-like protein (EF-6)|
Length = 859
Score = 51.2 bits (121), Expect = 1e-06
Identities = 44/161 (27%), Positives = 77/161 (47%), Gaps = 15/161 (9%)
Frame = +1
Query: 1 LKEKYHGGVCDVAIVDDGKLQAESDSGEFWVLF--------GGFAP-IGKKTVSDDDVVL 153
L+++ GG +A+VD AE+++ + G P + +VS L
Sbjct: 197 LRDRERGGRAQIAVVD-----AENEATNLLRIMEAVLGCRSGSLCPSVPSNSVSQ----L 247
Query: 154 ETTAPKLYSI--NGGELKFEDI---PLTKAVLENTRCFLLDCGA-EMFVWVGRVTQLEDR 315
+ +LY + G +L +++ PLT+ +L+ C+LLD G ++++W GR + +++
Sbjct: 248 QKANVRLYHVCEKGTDLVVQELATRPLTQDLLQEDGCYLLDQGGFKIYMWQGRKSSPQEK 307
Query: 316 KAATKAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
KAA FI + P T V V G ES + + F SW
Sbjct: 308 KAALSRAVGFIQAKGYPNYTNVEVVNDGAESTAFQQLFWSW 348
Score = 30.8 bits (68), Expect = 1.5
Identities = 29/122 (23%), Positives = 51/122 (41%), Gaps = 4/122 (3%)
Frame = +1
Query: 85 FWVLFGGFAPIGKKTVSDDDVVLETTAPKLYSIN---GGELKFEDIPLTKAVLENTRCFL 255
FW GG AP ++V + P+L+ + G + E + + L+ L
Sbjct: 587 FWEALGGRAPYPSNKRLPEEVW--SIQPRLFECSSHAGCLVLTEVLFFGQEDLDKYDIML 644
Query: 256 LDCGAEMFVWVGRVTQLEDRKAATKAIEEFIIN-QKRPKTTRVTQVIQGYESHSLKSKFE 432
LD E+F+W+G ++A +E + +R T + V QG+E + F
Sbjct: 645 LDTCQEIFLWLGEAAGEWKKEAVAWGLEYLRTHPAERSLATPIFVVKQGHEPATFTGWFV 704
Query: 433 SW 438
+W
Sbjct: 705 TW 706
>AVIL_MOUSE (O88398) Advillin (p92) (Actin-binding protein DOC6)|
Length = 819
Score = 50.8 bits (120), Expect = 1e-06
Identities = 43/156 (27%), Positives = 81/156 (51%), Gaps = 10/156 (6%)
Frame = +1
Query: 1 LKEKYHGGVCDVAIVDDGKLQAESDSGEFWVLFG--GFAPIGKKTVSDDDV-VLETTAPK 171
++++ GG ++ +++ K A G VL G + K VSD+ + + ++
Sbjct: 194 IRDRERGGRAEIGVIEGDKEAASP--GLMTVLQDTLGRRSMIKPAVSDEIMDQQQKSSIM 251
Query: 172 LYSIN--GGELKFEDI---PLTKAVLENTRCFLLD-CGAEMFVWVGR-VTQLEDRKAATK 330
LY ++ G+L ++ PL + +L + C++LD G +++VW G+ T++E + A +K
Sbjct: 252 LYHVSDTAGQLSVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSK 311
Query: 331 AIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
A+ +FI + P +T V V G ES K F+ W
Sbjct: 312 AL-DFIKMKGYPSSTNVETVNDGAESAMFKQLFQKW 346
Score = 41.2 bits (95), Expect = 0.001
Identities = 29/122 (23%), Positives = 52/122 (42%), Gaps = 3/122 (2%)
Frame = +1
Query: 82 EFWVLFGG-FAPIGKKTVSDDDVVLETTAPKLYSINGGELKFEDIPLTKAVLENTRCFLL 258
EFW L GG A K + + + ++ + + G L E T+ L LL
Sbjct: 590 EFWDLLGGKTAYANDKRLQQETLDVQVRLFECSNKTGRFLVTEVTDFTQEDLSPGDVMLL 649
Query: 259 DCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQK--RPKTTRVTQVIQGYESHSLKSKFE 432
D ++F+W+G ++K A +E+++ R T + + QG+E + F
Sbjct: 650 DTWDQVFLWIGAEANATEKKGALSTAQEYLVTHPSGRDPDTPILIIKQGFEPPTFTGWFL 709
Query: 433 SW 438
+W
Sbjct: 710 AW 711
>VILD_DICDI (Q8WQ85) Villidin|
Length = 1704
Score = 50.1 bits (118), Expect = 2e-06
Identities = 39/160 (24%), Positives = 74/160 (46%), Gaps = 14/160 (8%)
Frame = +1
Query: 1 LKEKYHGGVCDVAIVDDGKLQAESDSGEFWVLFGGFA--PIGKKTVSDDDVVLETTAPKL 174
++ K GG + +D G+ + S +FW + GG + PI T + ++ E+ +
Sbjct: 1087 IRTKERGGKSTLIQLDQGR---DEQSFDFWEILGGNSSDPIAT-TPTPEEQDTESIKTTI 1142
Query: 175 YSINGGELKFEDIPL------------TKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRK 318
Y + G ++K + K +L +++DC E+FVWVG+ + RK
Sbjct: 1143 YRV-GLDVKKNSLRARLAWEGTDWKLPNKEILNTKFVYVVDCVTEIFVWVGKESSSIQRK 1201
Query: 319 AATKAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
ATK + R T++T++ + E++ K KF ++
Sbjct: 1202 MATKVALVLQAQKDRVDWTKITRLTEFGENNLFKEKFANY 1241
Score = 34.3 bits (77), Expect = 0.14
Identities = 31/159 (19%), Positives = 67/159 (42%), Gaps = 13/159 (8%)
Frame = +1
Query: 1 LKEKYHGGVCDVAIVDDGKLQAESDSGEFWVLFGGFAPIGKKTVSDDDVVLETTAPKLYS 180
+ E ++ + I+ +G S+S EFW F G++ +D ++ ++ P ++
Sbjct: 1464 IAENFNSTSAPIEILKEG-----SESNEFWSAFESTG--GRQKYFNDIMIQSSSIPTSFT 1516
Query: 181 I----------NGGELKFEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATK 330
+G E+ P ++ L+ +LD + +++W+G ++A+ +
Sbjct: 1517 YKPRFFVCSNASGIVEVTEESPFSQDDLDIGSVCILDVQSHIYLWIGSRATHRTKRASME 1576
Query: 331 AIEEFIINQKRPKTTRVTQVIQG---YESHSLKSKFESW 438
+ FI K + T+V+ E KS F +W
Sbjct: 1577 VVLNFIETSKLGHSKEHTKVLIATPFEEPIGFKSYFRAW 1615
Score = 31.2 bits (69), Expect = 1.2
Identities = 20/82 (24%), Positives = 37/82 (45%)
Frame = +1
Query: 193 ELKFEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQKRPKT 372
+++ + L+ + L F+LD G +FVW G T ++ A ++ K+
Sbjct: 1037 KIRVRMVKLSTSSLNCHNSFILDAGPRIFVWAGSKTSRVNKAKALDFANRIRTKERGGKS 1096
Query: 373 TRVTQVIQGYESHSLKSKFESW 438
T + Q+ QG + S F+ W
Sbjct: 1097 TLI-QLDQGRDEQS----FDFW 1113
>VILI_CHICK (P02640) Villin-1|
Length = 826
Score = 46.2 bits (108), Expect = 4e-05
Identities = 35/145 (24%), Positives = 67/145 (46%), Gaps = 7/145 (4%)
Frame = +1
Query: 25 VCDVAIVDDGKLQAES-DSGEFWVLFGGFAPIGK-KTVSDDDVVLETTAPKLYSIN---G 189
V D+ + + AE + EFWV GG K + +++ + P+L+ + G
Sbjct: 573 VADIISKTEKPVVAEGQEPPEFWVALGGKTSYANSKRLQEEN---PSVPPRLFECSNKTG 629
Query: 190 GELKFEDIPLTKAVLENTRCFLLDCGAEMFVWVGRVTQLEDRKAATKAIEEFIINQ--KR 363
L E + T+ L+ +LLD ++F W+G+ +++AA + +E++ + R
Sbjct: 630 RFLATEIVDFTQDDLDENDVYLLDTWDQIFFWIGKGANESEKEAAAETAQEYLRSHPGSR 689
Query: 364 PKTTRVTQVIQGYESHSLKSKFESW 438
T + V QG+E + F +W
Sbjct: 690 DLDTPIIVVKQGFEPPTFTGWFMAW 714
Score = 45.4 bits (106), Expect = 6e-05
Identities = 32/113 (28%), Positives = 57/113 (50%), Gaps = 8/113 (7%)
Frame = +1
Query: 124 KTVSDDDVVLET--TAPKLYSIN--GGELKFEDI---PLTKAVLENTRCFLLD-CGAEMF 279
K + D+ V + +A KLY ++ G L +++ PLT+ +L++ C++LD G ++F
Sbjct: 237 KAATPDEQVHQALNSALKLYHVSDASGNLVIQEVAIRPLTQDMLQHEDCYILDQAGLKIF 296
Query: 280 VWVGRVTQLEDRKAATKAIEEFIINQKRPKTTRVTQVIQGYESHSLKSKFESW 438
VW G+ E+++ A FI + +T V G ES + F+ W
Sbjct: 297 VWKGKNANKEEKQQAMSRALGFIKAKNYLASTSVETENDGSESAVFRQLFQKW 349
>MUC5B_HUMAN (Q9HC84) Mucin-5B precursor (Mucin 5 subtype B, tracheobronchial)|
(High molecular weight salivary mucin MG1) (Sublingual
gland mucin)
Length = 5703
Score = 28.5 bits (62), Expect = 7.6
Identities = 13/31 (41%), Positives = 19/31 (61%), Gaps = 2/31 (6%)
Frame = -3
Query: 104 PPK--RTQNSPESDSACSFPSSTIATSHTPP 18
PP+ T +P + S+ PSS + T+HTPP
Sbjct: 3915 PPELTTTATTPAATSSTVTPSSALGTTHTPP 3945
Score = 28.1 bits (61), Expect = 9.9
Identities = 11/25 (44%), Positives = 16/25 (64%)
Frame = -3
Query: 92 TQNSPESDSACSFPSSTIATSHTPP 18
T +P + S+ PSS + T+HTPP
Sbjct: 3392 TATTPAATSSTVTPSSALGTTHTPP 3416
Score = 28.1 bits (61), Expect = 9.9
Identities = 11/25 (44%), Positives = 16/25 (64%)
Frame = -3
Query: 92 TQNSPESDSACSFPSSTIATSHTPP 18
T +P + S+ PSS + T+HTPP
Sbjct: 2694 TATTPAATSSTVTPSSALGTTHTPP 2718
Score = 28.1 bits (61), Expect = 9.9
Identities = 11/25 (44%), Positives = 16/25 (64%)
Frame = -3
Query: 92 TQNSPESDSACSFPSSTIATSHTPP 18
T +P + S+ PSS + T+HTPP
Sbjct: 2165 TATTPAATSSTVTPSSALGTTHTPP 2189
>SYW_BLOFL (Q7VRN5) Tryptophanyl-tRNA synthetase (EC 6.1.1.2)|
(Tryptophan--tRNA ligase) (TrpRS)
Length = 334
Score = 28.1 bits (61), Expect = 9.9
Identities = 19/46 (41%), Positives = 24/46 (52%), Gaps = 1/46 (2%)
Frame = -2
Query: 342 LLNGFSG-SFSVLELCYPTNPYKHFSPTVK*ETSCVLKDCFCKRYI 208
+L+G SG S LE + + Y V E SC+LKD C RYI
Sbjct: 249 ILSGISGQSILNLEESFQSKTYAQLKDVVIQELSCMLKDLQC-RYI 293
Database: uniprot_sprot.fasta
Posted date: May 25, 2006 5:36 PM
Number of letters in database: 80,573,946
Number of sequences in database: 219,361
Lambda K H
0.317 0.136 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,067,834
Number of Sequences: 219361
Number of extensions: 1169491
Number of successful extensions: 3554
Number of sequences better than 10.0: 54
Number of HSP's better than 10.0 without gapping: 3369
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3536
length of database: 80,573,946
effective HSP length: 101
effective length of database: 58,418,485
effective search space used: 2570413340
frameshift window, decay const: 50, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)