ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bart32g12 |
|---|---|
| Clone Library Name | barley_pub |
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 126 bits (316), Expect = 3e-29 Identities = 67/142 (47%), Positives = 97/142 (68%), Gaps = 4/142 (2%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV---EIIHRDVKT 252 +LVY F++NG++ D L+G A + L WP RL+IA+ A LAYLH +IHRDVK+ Sbjct: 665 ILVYPFMSNGSLLDRLYGEPAKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKS 724 Query: 251 TNILLDNSFHVKVADFGLSRLFPLEV-THVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTS 75 +NILLD+S KVADFG S+ P E ++VS +GT GY+DP Y++ +L++KSDV + Sbjct: 725 SNILLDHSMCAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSF 784 Query: 74 GVVLVELISSKPGVNMSRSHSE 9 GVVL+E++S + +N+ R E Sbjct: 785 GVVLLEIVSGREPLNIKRPRVE 806
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 125 bits (313), Expect = 7e-29 Identities = 66/142 (46%), Positives = 96/142 (67%), Gaps = 4/142 (2%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV---EIIHRDVKT 252 +LVY F++NG++ D L+G + + L WP RL+IA+ A LAYLH +IHRDVK+ Sbjct: 666 ILVYPFMSNGSLLDRLYGEASKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKS 725 Query: 251 TNILLDNSFHVKVADFGLSRLFPLEV-THVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTS 75 +NILLD S KVADFG S+ P E ++VS +GT GY+DP Y++ +L++KSDV + Sbjct: 726 SNILLDQSMCAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSF 785 Query: 74 GVVLVELISSKPGVNMSRSHSE 9 GVVL+E++S + +N+ R E Sbjct: 786 GVVLLEIVSGREPLNIKRPRIE 807
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 118 bits (296), Expect = 7e-27 Identities = 63/144 (43%), Positives = 94/144 (65%), Gaps = 5/144 (3%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRA-AERGLTWPLRLNIAIETAEALAYLHPVE---IIHRDVK 255 LLVYEF+A+G++ HLHG ++ L W R+ IA++ A + YLH +IHRD+K Sbjct: 577 LLVYEFMAHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIK 636 Query: 254 TTNILLDNSFHVKVADFGLSRLFPLEV-THVSTVPQGTPGYVDPVYHQCYKLTDKSDVST 78 ++NIL+D + +VADFGLS L P + T +S +P GT GY+DP Y++ + LT KSDV + Sbjct: 637 SSNILIDEDHNARVADFGLSILGPADSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYS 696 Query: 77 SGVVLVELISSKPGVNMSRSHSEI 6 GVVL+E++S + ++M I Sbjct: 697 FGVVLLEILSGRKAIDMQFEEGNI 720
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 114 bits (285), Expect = 1e-25 Identities = 63/144 (43%), Positives = 88/144 (61%), Gaps = 4/144 (2%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE---IIHRDVKT 252 LLVYEF+ G++ DHLH + L W +R+ IA A+ L +LH +I+RD K+ Sbjct: 157 LLVYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKS 216 Query: 251 TNILLDNSFHVKVADFGLSRLFPL-EVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTS 75 +NILLD FH K++DFGL++L P + +HVST GT GY P Y +LT KSDV + Sbjct: 217 SNILLDEGFHPKLSDFGLAKLGPTGDKSHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYSF 276 Query: 74 GVVLVELISSKPGVNMSRSHSEIN 3 GVV +ELI+ + ++ H E N Sbjct: 277 GVVFLELITGRKAIDSEMPHGEQN 300
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 114 bits (284), Expect = 2e-25 Identities = 61/140 (43%), Positives = 94/140 (67%), Gaps = 4/140 (2%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH---PVEIIHRDVK 255 ++L+YE++AN + D+L G R+ L+W RL I+++ A+ L YLH I+HRDVK Sbjct: 642 MVLIYEYMANENLGDYLAGKRSFI--LSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVK 699 Query: 254 TTNILLDNSFHVKVADFGLSRLFPLEVT-HVSTVPQGTPGYVDPVYHQCYKLTDKSDVST 78 TNILL+ K+ADFGLSR F +E + +STV G+ GY+DP Y+ ++ +KSDV + Sbjct: 700 PTNILLNEKLQAKMADFGLSRSFSVEGSGQISTVVAGSIGYLDPEYYSTRQMNEKSDVYS 759 Query: 77 SGVVLVELISSKPGVNMSRS 18 GVVL+E+I+ +P + S++ Sbjct: 760 LGVVLLEVITGQPAIASSKT 779
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 113 bits (283), Expect = 2e-25 Identities = 65/145 (44%), Positives = 83/145 (57%), Gaps = 3/145 (2%) Frame = -2 Query: 434 SRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHP---VEIIHR 264 S + LLVYE++ NG++ L L W RL IA+ A LA+LH IIHR Sbjct: 983 SEEKLLVYEYMVNGSLDHWLRNQTGMLEVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHR 1042 Query: 263 DVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDV 84 D+K +NILLD F KVADFGL+RL +HVSTV GT GY+ P Y Q + T K DV Sbjct: 1043 DIKASNILLDGDFEPKVADFGLARLISACESHVSTVIAGTFGYIPPEYGQSARATTKGDV 1102 Query: 83 STSGVVLVELISSKPGVNMSRSHSE 9 + GV+L+EL++ K SE Sbjct: 1103 YSFGVILLELVTGKEPTGPDFKESE 1127
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 113 bits (282), Expect = 3e-25 Identities = 64/143 (44%), Positives = 93/143 (65%), Gaps = 3/143 (2%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE--IIHRDVKTT 249 LLVYEF+ G++ +HL + L+W LRL +A+ A+ LA+LH E +I+RD KT+ Sbjct: 148 LLVYEFMPRGSLENHLFRRGLYFQPLSWKLRLKVALGAAKGLAFLHSSETRVIYRDFKTS 207 Query: 248 NILLDNSFHVKVADFGLSRLFPL-EVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSG 72 NILLD+ ++ K++DFGL++ P+ + +HVST GT GY P Y LT KSDV + G Sbjct: 208 NILLDSEYNAKLSDFGLAKDGPIGDKSHVSTRVMGTHGYAAPEYLATGHLTTKSDVYSFG 267 Query: 71 VVLVELISSKPGVNMSRSHSEIN 3 VVL+EL+S + V+ +R E N Sbjct: 268 VVLLELLSGRRAVDKNRPSGERN 290
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 112 bits (279), Expect = 6e-25 Identities = 59/137 (43%), Positives = 87/137 (63%), Gaps = 4/137 (2%) Frame = -2 Query: 440 RMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHP---VEII 270 ++ + LLVYE++ G++ D LH + L WP R IAI A LA+LH II Sbjct: 952 KVGEERLLVYEYMKYGSLEDVLHDRKKTGIKLNWPARRKIAIGAARGLAFLHHNCIPHII 1011 Query: 269 HRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVS-TVPQGTPGYVDPVYHQCYKLTDK 93 HRD+K++N+LLD + +V+DFG++RL TH+S + GTPGYV P Y+Q ++ + K Sbjct: 1012 HRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTK 1071 Query: 92 SDVSTSGVVLVELISSK 42 DV + GVVL+EL++ K Sbjct: 1072 GDVYSYGVVLLELLTGK 1088
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 111 bits (278), Expect = 8e-25 Identities = 60/137 (43%), Positives = 88/137 (64%), Gaps = 4/137 (2%) Frame = -2 Query: 440 RMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH---PVEII 270 ++ + LLVYEF+ G++ D LH + A L W R IAI +A LA+LH II Sbjct: 947 KVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHII 1006 Query: 269 HRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVS-TVPQGTPGYVDPVYHQCYKLTDK 93 HRD+K++N+LLD + +V+DFG++RL TH+S + GTPGYV P Y+Q ++ + K Sbjct: 1007 HRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTK 1066 Query: 92 SDVSTSGVVLVELISSK 42 DV + GVVL+EL++ K Sbjct: 1067 GDVYSYGVVLLELLTGK 1083
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 111 bits (278), Expect = 8e-25 Identities = 59/137 (43%), Positives = 87/137 (63%), Gaps = 4/137 (2%) Frame = -2 Query: 440 RMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHP---VEII 270 ++ + LLVYE++ G++ D LH + L WP R IAI A LA+LH II Sbjct: 952 KVGEERLLVYEYMKYGSLEDVLHDRKKIGIKLNWPARRKIAIGAARGLAFLHHNCIPHII 1011 Query: 269 HRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVS-TVPQGTPGYVDPVYHQCYKLTDK 93 HRD+K++N+LLD + +V+DFG++RL TH+S + GTPGYV P Y+Q ++ + K Sbjct: 1012 HRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTK 1071 Query: 92 SDVSTSGVVLVELISSK 42 DV + GVVL+EL++ K Sbjct: 1072 GDVYSYGVVLLELLTGK 1088
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 110 bits (275), Expect = 2e-24 Identities = 61/137 (44%), Positives = 86/137 (62%), Gaps = 3/137 (2%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHP---VEIIHRDVKT 252 LLVY ++ANG+VA L ++ L WP R IA+ +A LAYLH +IIHRDVK Sbjct: 360 LLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKA 419 Query: 251 TNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSG 72 NILLD F V DFGL++L + THV+T +GT G++ P Y K ++K+DV G Sbjct: 420 ANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYG 479 Query: 71 VVLVELISSKPGVNMSR 21 V+L+ELI+ + +++R Sbjct: 480 VMLLELITGQRAFDLAR 496
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 109 bits (273), Expect = 3e-24 Identities = 62/141 (43%), Positives = 92/141 (65%), Gaps = 3/141 (2%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE--IIHRDVKTT 249 LLVYEF+ G++ +HL + + L+W LRL +A+ A+ LA+LH E +I+RD KT+ Sbjct: 149 LLVYEFMPRGSLENHLFRRGSYFQPLSWTLRLKVALGAAKGLAFLHNAETSVIYRDFKTS 208 Query: 248 NILLDNSFHVKVADFGLSRLFPL-EVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSG 72 NILLD+ ++ K++DFGL++ P + +HVST GT GY P Y LT KSDV + G Sbjct: 209 NILLDSEYNAKLSDFGLAKDGPTGDKSHVSTRIMGTYGYAAPEYLATGHLTTKSDVYSYG 268 Query: 71 VVLVELISSKPGVNMSRSHSE 9 VVL+E++S + V+ +R E Sbjct: 269 VVLLEVLSGRRAVDKNRPPGE 289
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 108 bits (269), Expect = 9e-24 Identities = 58/133 (43%), Positives = 87/133 (65%), Gaps = 6/133 (4%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH---PVEIIHRDVKT 252 LLVYE++ NG++AD LHG R L WP RL IA++ AE L+YLH I+HRDVK+ Sbjct: 763 LLVYEYMPNGSLADVLHGDRKGGVVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVKS 822 Query: 251 TNILLDNSFHVKVADFGLSRLFPL---EVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVS 81 +NILLD+ + KVADFG++++ + + + G+ GY+ P Y ++ +KSD+ Sbjct: 823 SNILLDSDYGAKVADFGIAKVGQMSGSKTPEAMSGIAGSCGYIAPEYVYTLRVNEKSDIY 882 Query: 80 TSGVVLVELISSK 42 + GVVL+EL++ K Sbjct: 883 SFGVVLLELVTGK 895
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 107 bits (267), Expect = 2e-23 Identities = 60/139 (43%), Positives = 87/139 (62%), Gaps = 6/139 (4%) Frame = -2 Query: 440 RMSRDLLLVYEFIANGTVADHLHGCRAAE--RGLTWPLRLNIAIETAEALAYLHP---VE 276 ++ + LLVYEF+ G++ + LHG R E R L W R IA A+ L +LH Sbjct: 902 KIGEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPH 961 Query: 275 IIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVS-TVPQGTPGYVDPVYHQCYKLT 99 IIHRD+K++N+LLD +V+DFG++RL TH+S + GTPGYV P Y+Q ++ T Sbjct: 962 IIHRDMKSSNVLLDQDMEARVSDFGMARLISALDTHLSVSTLAGTPGYVPPEYYQSFRCT 1021 Query: 98 DKSDVSTSGVVLVELISSK 42 K DV + GVV++E++S K Sbjct: 1022 AKGDVYSIGVVMLEILSGK 1040
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 107 bits (267), Expect = 2e-23 Identities = 60/143 (41%), Positives = 89/143 (62%), Gaps = 6/143 (4%) Frame = -2 Query: 440 RMSRDLLLVYEFIANGTVADHLHGCRAAERG--LTWPLRLNIAIETAEALAYLHPV---E 276 ++ + LLVYE++ G++ LH + + G L W R IAI A LA+LH Sbjct: 923 KVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPH 982 Query: 275 IIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVS-TVPQGTPGYVDPVYHQCYKLT 99 IIHRD+K++N+LLD F +V+DFG++RL TH+S + GTPGYV P Y+Q ++ T Sbjct: 983 IIHRDMKSSNVLLDEDFEARVSDFGMARLVSALDTHLSVSTLAGTPGYVPPEYYQSFRCT 1042 Query: 98 DKSDVSTSGVVLVELISSKPGVN 30 K DV + GV+L+EL+S K ++ Sbjct: 1043 AKGDVYSYGVILLELLSGKKPID 1065
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 107 bits (266), Expect = 2e-23 Identities = 62/139 (44%), Positives = 83/139 (59%), Gaps = 3/139 (2%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHP---VEIIHRDV 258 D LL+Y ++ NG++ LH L W RL IA A+ L YLH I+HRD+ Sbjct: 802 DRLLIYSYMENGSLDYWLHERNDGPALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDI 861 Query: 257 KTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVST 78 K++NILLD +F+ +ADFGL+RL THVST GT GY+ P Y Q T K DV + Sbjct: 862 KSSNILLDENFNSHLADFGLARLMSPYETHVSTDLVGTLGYIPPEYGQASVATYKGDVYS 921 Query: 77 SGVVLVELISSKPGVNMSR 21 GVVL+EL++ K V+M + Sbjct: 922 FGVVLLELLTDKRPVDMCK 940
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 106 bits (265), Expect = 3e-23 Identities = 58/144 (40%), Positives = 89/144 (61%), Gaps = 4/144 (2%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHP---VEIIHRDVKT 252 LLVYE++ G++ DHLH + ++ L W R+ IA A L YLH +I+RD+K Sbjct: 174 LLVYEYMPQGSLEDHLHVLPSGKKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKC 233 Query: 251 TNILLDNSFHVKVADFGLSRLFPL-EVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTS 75 +NILL + K++DFGL+++ P + THVST GT GY P Y +LT KSD+ + Sbjct: 234 SNILLGEDYQPKLSDFGLAKVGPSGDKTHVSTRVMGTYGYCAPDYAMTGQLTFKSDIYSF 293 Query: 74 GVVLVELISSKPGVNMSRSHSEIN 3 GVVL+ELI+ + ++ +++ + N Sbjct: 294 GVVLLELITGRKAIDNTKTRKDQN 317
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 104 bits (260), Expect = 1e-22 Identities = 60/144 (41%), Positives = 89/144 (61%), Gaps = 7/144 (4%) Frame = -2 Query: 440 RMSRDLLLVYEFIANGTVADHLHGCRAAERG---LTWPLRLNIAIETAEALAYLHPV--- 279 ++ + LLVYE++ G++ LH ++G L W R IAI A LA+LH Sbjct: 922 KIGEERLLVYEYMKYGSLETVLH--EKTKKGGIFLDWSARKKIAIGAARGLAFLHHSCIP 979 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVS-TVPQGTPGYVDPVYHQCYKL 102 IIHRD+K++N+LLD F +V+DFG++RL TH+S + GTPGYV P Y+Q ++ Sbjct: 980 HIIHRDMKSSNVLLDQDFVARVSDFGMARLVSALDTHLSVSTLAGTPGYVPPEYYQSFRC 1039 Query: 101 TDKSDVSTSGVVLVELISSKPGVN 30 T K DV + GV+L+EL+S K ++ Sbjct: 1040 TAKGDVYSYGVILLELLSGKKPID 1063
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 103 bits (257), Expect = 2e-22 Identities = 58/143 (40%), Positives = 91/143 (63%), Gaps = 3/143 (2%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE--IIHRDVKTT 249 LLVYEF+ G++ +HL + L+W R+ +A+ A LA+LH + +I+RD K + Sbjct: 148 LLVYEFMTRGSLENHLFRRGTFYQPLSWNTRVRMALGAARGLAFLHNAQPQVIYRDFKAS 207 Query: 248 NILLDNSFHVKVADFGLSRLFPL-EVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSG 72 NILLD++++ K++DFGL+R P+ + +HVST GT GY P Y L+ KSDV + G Sbjct: 208 NILLDSNYNAKLSDFGLARDGPMGDNSHVSTRVMGTQGYAAPEYLATGHLSVKSDVYSFG 267 Query: 71 VVLVELISSKPGVNMSRSHSEIN 3 VVL+EL+S + ++ ++ E N Sbjct: 268 VVLLELLSGRRAIDKNQPVGEHN 290
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 101 bits (251), Expect = 1e-21 Identities = 59/132 (44%), Positives = 79/132 (59%), Gaps = 3/132 (2%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV---EIIHRDV 258 D LL+Y ++ NG++ LH L W RL IA AE LAYLH I+HRD+ Sbjct: 811 DKLLIYSYMDNGSLDYWLHEKVDGPPSLDWKTRLRIARGAAEGLAYLHQSCEPHILHRDI 870 Query: 257 KTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVST 78 K++NILL ++F +ADFGL+RL THV+T GT GY+ P Y Q T K DV + Sbjct: 871 KSSNILLSDTFVAHLADFGLARLILPYDTHVTTDLVGTLGYIPPEYGQASVATYKGDVYS 930 Query: 77 SGVVLVELISSK 42 GVVL+EL++ + Sbjct: 931 FGVVLLELLTGR 942
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 100 bits (250), Expect = 1e-21 Identities = 60/147 (40%), Positives = 85/147 (57%), Gaps = 3/147 (2%) Frame = -2 Query: 440 RMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV--EIIH 267 R ++LLLVYEF+ G++ HL W LR+ I I A LA+LH + E+I+ Sbjct: 160 REDKELLLVYEFMPKGSLESHLF---RRNDPFPWDLRIKIVIGAARGLAFLHSLQREVIY 216 Query: 266 RDVKTTNILLDNSFHVKVADFGLSRLFPL-EVTHVSTVPQGTPGYVDPVYHQCYKLTDKS 90 RD K +NILLD+++ K++DFGL++L P E +HV+T GT GY P Y L KS Sbjct: 217 RDFKASNILLDSNYDAKLSDFGLAKLGPADEKSHVTTRIMGTYGYAAPEYMATGHLYVKS 276 Query: 89 DVSTSGVVLVELISSKPGVNMSRSHSE 9 DV GVVL+E+++ N R + Sbjct: 277 DVFAFGVVLLEIMTGLTAHNTKRPRGQ 303
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 99.0 bits (245), Expect = 5e-21 Identities = 58/135 (42%), Positives = 83/135 (61%), Gaps = 5/135 (3%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH----PVEIIHRDVK 255 LL+YE++ NG++ + LHG + L W R +A+E A+ L YLH P+ I+HRDVK Sbjct: 763 LLLYEYMPNGSLGELLHGSKGGH--LQWETRHRVAVEAAKGLCYLHHDCSPL-ILHRDVK 819 Query: 254 TTNILLDNSFHVKVADFGLSR-LFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVST 78 + NILLD+ F VADFGL++ L + + G+ GY+ P Y K+ +KSDV + Sbjct: 820 SNNILLDSDFEAHVADFGLAKFLVDGAASECMSSIAGSYGYIAPEYAYTLKVDEKSDVYS 879 Query: 77 SGVVLVELISSKPGV 33 GVVL+ELI+ K V Sbjct: 880 FGVVLLELIAGKKPV 894
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 95.5 bits (236), Expect = 6e-20 Identities = 58/146 (39%), Positives = 84/146 (57%), Gaps = 6/146 (4%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLT---WPLRLNIAIETAEALAYLHPV---EIIHRD 261 LLVYE++ GT++ HL +E GL W RL +A++ A + YLH + IHRD Sbjct: 660 LLVYEYMPQGTLSRHLF--EWSEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQSFIHRD 717 Query: 260 VKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVS 81 +K +NILL + KVADFGL RL P + T GT GY+ P Y ++T K DV Sbjct: 718 LKPSNILLGDDMRAKVADFGLVRLAPEGKGSIETRIAGTFGYLAPEYAVTGRVTTKVDVY 777 Query: 80 TSGVVLVELISSKPGVNMSRSHSEIN 3 + GV+L+ELI+ + ++ S+ I+ Sbjct: 778 SFGVILMELITGRKSLDESQPEESIH 803
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 89.0 bits (219), Expect = 6e-18 Identities = 54/137 (39%), Positives = 79/137 (57%), Gaps = 4/137 (2%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH---PVEIIHRDVKT 252 L++Y ++ NG++ D LH + L W R NIA+ TA LAYLH I+HRD+K Sbjct: 887 LILYTYMENGSLHDILHETNPP-KPLDWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKP 945 Query: 251 TNILLDNSFHVKVADFGLSRLFPLEVTHV-STVPQGTPGYVDPVYHQCYKLTDKSDVSTS 75 NILLD+ ++DFG+++L T + S QGT GY+ P + +SDV + Sbjct: 946 MNILLDSDLEPHISDFGIAKLLDQSATSIPSNTVQGTIGYMAPENAFTTVKSRESDVYSY 1005 Query: 74 GVVLVELISSKPGVNMS 24 GVVL+ELI+ K ++ S Sbjct: 1006 GVVLLELITRKKALDPS 1022
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 88.2 bits (217), Expect = 9e-18 Identities = 49/131 (37%), Positives = 78/131 (59%), Gaps = 4/131 (3%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHP---VEIIHRDVKT 252 +L+YE++ N ++ +L G + L W R +I A L YLH IIHRD+K Sbjct: 598 MLIYEYLENLSLDSYLFG-KTRRSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKV 656 Query: 251 TNILLDNSFHVKVADFGLSRLFPLEVTHVSTVP-QGTPGYVDPVYHQCYKLTDKSDVSTS 75 +NILLD + K++DFG++R+F + T +T+ GT GY+ P Y ++KSDV + Sbjct: 657 SNILLDKNMIPKISDFGMARIFERDETEANTMKVVGTYGYMSPEYAMYGIFSEKSDVFSF 716 Query: 74 GVVLVELISSK 42 GV+++E++S K Sbjct: 717 GVIVLEIVSGK 727
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 87.0 bits (214), Expect = 2e-17 Identities = 53/137 (38%), Positives = 80/137 (58%), Gaps = 1/137 (0%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 DL LVY ++ NG++ D L C L+W +R IA A + +LH IHRD+K+ Sbjct: 257 DLCLVYVYMPNGSLLDRL-SCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSA 315 Query: 248 NILLDNSFHVKVADFGLSRLF-PLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSG 72 NILLD +F K++DFGL+R T +++ GT Y+ P + ++T KSD+ + G Sbjct: 316 NILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFG 374 Query: 71 VVLVELISSKPGVNMSR 21 VVL+E+I+ P V+ R Sbjct: 375 VVLLEIITGLPAVDEHR 391
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 86.7 bits (213), Expect = 3e-17 Identities = 54/139 (38%), Positives = 81/139 (58%), Gaps = 1/139 (0%) Frame = -2 Query: 434 SRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVK 255 S +L LVY ++ NG++ D L C L+W R +A TA + +LH IHRD+K Sbjct: 255 SDNLCLVYAYMPNGSLLDRL-SCLDGTPPLSWHTRCKVAQGTANGIRFLHENHHIHRDIK 313 Query: 254 TTNILLDNSFHVKVADFGLSRLFP-LEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVST 78 + NILLD F K++DFGL+R L T +++ GT Y+ P + ++T KSD+ + Sbjct: 314 SANILLDKDFTAKISDFGLARASARLAQTVMTSRIVGTTAYMAPEALR-GEITPKSDIYS 372 Query: 77 SGVVLVELISSKPGVNMSR 21 GVVL+ELI+ V+ +R Sbjct: 373 FGVVLLELITGLAAVDENR 391
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 81.6 bits (200), Expect = 9e-16 Identities = 55/133 (41%), Positives = 75/133 (56%), Gaps = 8/133 (6%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV---EIIHRDVKT 252 LLV E++ NG++A+ L L W R NIA+ A+ LAYLH +IH DVK Sbjct: 603 LLVSEYVENGSLANILFS-EGGNILLDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKP 661 Query: 251 TNILLDNSFHVKVADFGLSRLF-----PLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSD 87 NILLD +F K+ DFGL +L V+HV +GT GY+ P + +T K D Sbjct: 662 ENILLDQAFEPKITDFGLVKLLNRGGSTQNVSHV----RGTLGYIAPEWVSSLPITAKVD 717 Query: 86 VSTSGVVLVELIS 48 V + GVVL+EL++ Sbjct: 718 VYSYGVVLLELLT 730
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 81.3 bits (199), Expect = 1e-15 Identities = 45/133 (33%), Positives = 73/133 (54%), Gaps = 4/133 (3%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHP---VEIIHRDVKT 252 LL+Y+++ N ++ D LH + + L W R IA+ A LAYLH V IIH ++++ Sbjct: 444 LLIYDYLPNISLHDLLHESKPRKPALNWARRHKIALGIARGLAYLHTGQEVPIIHGNIRS 503 Query: 251 TNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSG 72 N+L+D+ F ++ +FGL ++ V + GY P H+ K +SDV G Sbjct: 504 KNVLVDDFFFARLTEFGLDKIMVQAVADEIVSQAKSDGYKAPELHKMKKCNPRSDVYAFG 563 Query: 71 VVLVE-LISSKPG 36 ++L+E L+ KPG Sbjct: 564 ILLLEILMGKKPG 576
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 79.0 bits (193), Expect = 6e-15 Identities = 50/140 (35%), Positives = 76/140 (54%), Gaps = 11/140 (7%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH--PVEIIHRDVKTTN 246 LVY F+ NG++ D LH A L+WP RL+I + TA A+ +LH +IH D+K++N Sbjct: 286 LVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSN 345 Query: 245 ILLDNSFHVKVADFGLSRLFPL---------EVTHVSTVPQGTPGYVDPVYHQCYKLTDK 93 +LLD K+ DFGL+R V STV +GT Y+ Y + +L Sbjct: 346 VLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTV-RGTLAYLPEEYIKTGRLAVD 404 Query: 92 SDVSTSGVVLVELISSKPGV 33 +D + GVV++E ++ + V Sbjct: 405 TDTFSFGVVILETLAGQRAV 424
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 77.0 bits (188), Expect = 2e-14 Identities = 49/140 (35%), Positives = 75/140 (53%), Gaps = 11/140 (7%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH--PVEIIHRDVKTTN 246 LVY F+ NG++ D LH A L+WP RL+I + TA A+ +LH +IH D+K++N Sbjct: 286 LVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSN 345 Query: 245 ILLDNSFHVKVADFGLSRLFPLE---------VTHVSTVPQGTPGYVDPVYHQCYKLTDK 93 +LLD K+ DFGL+R V TV +GT Y+ Y + +L Sbjct: 346 VLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTV-RGTLAYLPEEYIKTGRLAVD 404 Query: 92 SDVSTSGVVLVELISSKPGV 33 +D + GVV++E ++ + V Sbjct: 405 TDTFSFGVVVLETLAGQRAV 424
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 75.9 bits (185), Expect = 5e-14 Identities = 48/135 (35%), Positives = 77/135 (57%), Gaps = 9/135 (6%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE--IIHRDVKTTN 246 +V E++ NG++ + LH + + WPLR I E A + YLH + ++H D+KT N Sbjct: 93 IVTEYMPNGSLNELLHR-KTEYPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQN 151 Query: 245 ILLDNSFHVKVADFGLSRLFPLEV----THVSTVPQGTPGYVDPVYH---QCYKLTDKSD 87 ILLDN FHVK+ADFGLS+ + + ++ S GT Y+ P + Q + + K D Sbjct: 152 ILLDNEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHD 211 Query: 86 VSTSGVVLVELISSK 42 + + V++ E++S K Sbjct: 212 IYSYAVIMWEVLSRK 226
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 74.3 bits (181), Expect = 1e-13 Identities = 51/135 (37%), Positives = 78/135 (57%), Gaps = 9/135 (6%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE--IIHRDVKTTN 246 +V E++ NG++ + LH + + WPLR I E A + YLH + ++H D+KT N Sbjct: 93 IVTEYMPNGSLNELLHR-KTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQN 151 Query: 245 ILLDNSFHVKVADFGLS--RLFPLEVTHVS-TVPQ-GTPGYVDPVYH---QCYKLTDKSD 87 ILLDN FHVK+ADFGLS R+ L + S + P+ GT Y+ P + Q + + K D Sbjct: 152 ILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHD 211 Query: 86 VSTSGVVLVELISSK 42 + + V+ E++S K Sbjct: 212 IYSYAVITWEVLSRK 226
>CLA4_ASHGO (Q9HFW2) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 793 Score = 72.0 bits (175), Expect = 7e-13 Identities = 43/133 (32%), Positives = 73/133 (54%), Gaps = 3/133 (2%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLH---GCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDV 258 DL +V E++ G++ D + G A+E +T P I ET + L +LH IIHRD+ Sbjct: 586 DLWVVMEYMEGGSLTDVIENSIGSDASESPMTEPQIAYIVRETCQGLKFLHDKHIIHRDI 645 Query: 257 KTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVST 78 K+ N+LLD VK+ DFG + + +T+ GTP ++ P + + +K DV + Sbjct: 646 KSDNVLLDTHGRVKITDFGFCAKLTDKRSKRATM-VGTPYWMAPEVVKQREYDEKVDVWS 704 Query: 77 SGVVLVELISSKP 39 G++ +E++ +P Sbjct: 705 LGIMTIEMLEGEP 717
>SHK2_SCHPO (Q10056) Serine/threonine-protein kinase shk2 (EC 2.7.11.1)| Length = 589 Score = 70.9 bits (172), Expect = 2e-12 Identities = 42/132 (31%), Positives = 75/132 (56%), Gaps = 1/132 (0%) Frame = -2 Query: 431 RDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKT 252 R L +V E++ G++ D + + E + I +ET + + +LH IIHRD+K+ Sbjct: 383 RHLWVVMEYMNAGSLTDIIEKSKLTEAQIA-----RICLETCKGIQHLHARNIIHRDIKS 437 Query: 251 TNILLDNSFHVKVADFGL-SRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTS 75 N+LLDNS ++K+ DFG +RL V+ V GTP ++ P + + K D+ + Sbjct: 438 DNVLLDNSGNIKITDFGFCARLSNRTNKRVTMV--GTPYWMAPEVVKQNEYGTKVDIWSL 495 Query: 74 GVVLVELISSKP 39 G++++E+I ++P Sbjct: 496 GIMIIEMIENEP 507
>CLA4_YEAST (P48562) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 842 Score = 70.9 bits (172), Expect = 2e-12 Identities = 45/138 (32%), Positives = 71/138 (51%), Gaps = 4/138 (2%) Frame = -2 Query: 440 RMSRDLLLVYEFIANGTVADHLHGCRAAERG---LTWPLRLNIAIETAEALAYLHPVEII 270 R DL +V EF+ G++ D + + LT P I ET + L +LH II Sbjct: 631 RTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHII 690 Query: 269 HRDVKTTNILLDNSFHVKVADFGL-SRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDK 93 HRD+K+ N+LLD VK+ DFG +RL + V GTP ++ P + + +K Sbjct: 691 HRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMV--GTPYWMAPEVVKQREYDEK 748 Query: 92 SDVSTSGVVLVELISSKP 39 DV + G++ +E++ +P Sbjct: 749 IDVWSLGIMTIEMLEGEP 766
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 70.9 bits (172), Expect = 2e-12 Identities = 49/139 (35%), Positives = 77/139 (55%), Gaps = 2/139 (1%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 ++L+ +L +V E+++ G++ LH A E+ L RL++A + A+ + YLH Sbjct: 608 IVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQ-LDERRRLSMAYDVAKGMNYLH 666 Query: 284 PVE--IIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQC 111 I+HRD+K+ N+L+D + VKV DFGLSRL S GTP ++ P + Sbjct: 667 NRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRL-KASTFLSSKSAAGTPEWMAPEVLRD 725 Query: 110 YKLTDKSDVSTSGVVLVEL 54 +KSDV + GV+L EL Sbjct: 726 EPSNEKSDVYSFGVILWEL 744
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 70.1 bits (170), Expect = 3e-12 Identities = 47/146 (32%), Positives = 75/146 (51%), Gaps = 7/146 (4%) Frame = -2 Query: 458 LYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAER--GLTWPLRLNIAIETAEALAYLH 285 LYG + + + L VY+ + G++ L +A LTW R +I++ TA + +LH Sbjct: 277 LYGYSIKGGKPCL-VYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLH 335 Query: 284 PVE---IIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQ--GTPGYVDPVY 120 +IH D+K NILLD K+ DFGL R P + V V + GT Y+ P + Sbjct: 336 TARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLDAVVEVNKVFGTKIYLPPEF 395 Query: 119 HQCYKLTDKSDVSTSGVVLVELISSK 42 +L+ DV + G+VL+E+ + + Sbjct: 396 RNFRQLSTGVDVYSFGIVLLEVFTGR 421
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 69.7 bits (169), Expect = 3e-12 Identities = 46/153 (30%), Positives = 86/153 (56%), Gaps = 5/153 (3%) Frame = -2 Query: 461 ILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHP 282 +L C +R +Y ++ANG++ D L G + L WP R++I A+ YLH Sbjct: 272 VLGFCAARQFHSF--IYPYMANGSLQDRLQG-QGGSDPLPWPQRVSICSGLLCAVEYLHG 328 Query: 281 VEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPL----EVTHVST-VPQGTPGYVDPVYH 117 +EIIH +VK++N+LLD + K+A ++ L P+ + T + T + + + Y+ + Sbjct: 329 LEIIHSNVKSSNVLLDQNLTPKLA-HPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFI 387 Query: 116 QCYKLTDKSDVSTSGVVLVELISSKPGVNMSRS 18 + +LT + D+ + G+VL E+++ P ++ +RS Sbjct: 388 RVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRS 420
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 68.6 bits (166), Expect = 8e-12 Identities = 51/159 (32%), Positives = 85/159 (53%), Gaps = 13/159 (8%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V +YG + L +V EF+A+G++ L L WPL+L I ET+ A+ +LH Sbjct: 96 VSIYGVCKQ---PLGIVMEFMASGSLEKTL-----PTHSLCWPLKLRIIHETSLAMNFLH 147 Query: 284 PVE--IIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTH---VSTVPQGTPGYVDPVY 120 ++ ++H D+K NILLDN+ HVK++DFGLS+ + +GT Y+ P Sbjct: 148 SIKPPLLHLDLKPGNILLDNNMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYIPP-- 205 Query: 119 HQCYKLTDKS-----DVSTSGVVLVELISSK---PGVNM 27 + + +K+ DV + +V+ E+++ K G+NM Sbjct: 206 -EMFLENNKAPGPEYDVYSFAIVIWEILTQKKPYAGLNM 243
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 68.2 bits (165), Expect = 1e-11 Identities = 43/134 (32%), Positives = 73/134 (54%), Gaps = 8/134 (5%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH---PVEIIHRDVK 255 L LVY +++NGT+ D L C L+W +R+++ I A+A+ YLH P +I +V Sbjct: 250 LCLVYPYMSNGTLFDRLQ-CTNGTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVS 308 Query: 254 TTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPG-----YVDPVYHQCYKLTDKS 90 + NILLD+ K+ DF + P ST+ G Y+ Y + +L+ K+ Sbjct: 309 SANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKT 368 Query: 89 DVSTSGVVLVELIS 48 DV + G+V++E+++ Sbjct: 369 DVYSFGIVIMEVLT 382
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 67.4 bits (163), Expect = 2e-11 Identities = 44/140 (31%), Positives = 76/140 (54%), Gaps = 6/140 (4%) Frame = -2 Query: 443 SRMSRDLLLVY-EFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIH 267 S ++ D L ++ E++ G+VA L + E L N +T + L YLH I+H Sbjct: 465 SNLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLV----KNFIKQTLKGLEYLHSRGIVH 520 Query: 266 RDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVP-----QGTPGYVDPVYHQCYKL 102 RD+K NIL+DN +K++DFG+S+ L T T QG+ ++ P + Sbjct: 521 RDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAPEVVKQTMH 580 Query: 101 TDKSDVSTSGVVLVELISSK 42 T+K+D+ + G +++E+++SK Sbjct: 581 TEKTDIWSLGCLVIEMLTSK 600
>M3K3_MOUSE (Q61084) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 66.6 bits (161), Expect = 3e-11 Identities = 45/143 (31%), Positives = 73/143 (51%), Gaps = 4/143 (2%) Frame = -2 Query: 455 YGCTSRMSRDLLLVY-EFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 YGC + +L ++ E++ G+V D L A +T I E ++YLH Sbjct: 428 YGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQIL----EGMSYLHSN 483 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFP---LEVTHVSTVPQGTPGYVDPVYHQCY 108 I+HRD+K NIL D++ +VK+ DFG S+ + T + +V GTP ++ P Sbjct: 484 MIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSV-TGTPYWMSPEVISGE 542 Query: 107 KLTDKSDVSTSGVVLVELISSKP 39 K+DV + G +VE+++ KP Sbjct: 543 GYGRKADVWSLGCTVVEMLTEKP 565
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 66.2 bits (160), Expect = 4e-11 Identities = 42/130 (32%), Positives = 68/130 (52%), Gaps = 6/130 (4%) Frame = -2 Query: 410 EFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNILL-- 237 E++ GT+ L ++ L+WP+RL++A++ A+ L YLH + HRD+ + N L+ Sbjct: 125 EYMNGGTLEQLL----SSPEPLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRR 180 Query: 236 -DNSFHVKVADFGLSRLFPLEVTHVSTVP---QGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 D F V DFGL+ P+ P G+P ++ P + +K+DV G+ Sbjct: 181 EDRGFTAVVGDFGLAEKIPVYREGTRKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGI 240 Query: 68 VLVELISSKP 39 VL ELI+ P Sbjct: 241 VLCELIARVP 250
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 66.2 bits (160), Expect = 4e-11 Identities = 41/127 (32%), Positives = 71/127 (55%), Gaps = 1/127 (0%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 +V E++ T+ +++ A L LNI + A+A+ H +I+HRD+K NIL Sbjct: 86 IVMEYVEGMTLKEYI----TANGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNIL 141 Query: 239 LDNSFHVKVADFGL-SRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVL 63 +D+ ++KV DFG+ + L +TH ++V G+ Y+ P + T KSD+ G+VL Sbjct: 142 IDHMGNIKVTDFGIATALSSTTITHTNSV-LGSVHYLSPEQARGGLATKKSDIYALGIVL 200 Query: 62 VELISSK 42 EL++ + Sbjct: 201 FELLTGR 207
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 66.2 bits (160), Expect = 4e-11 Identities = 42/130 (32%), Positives = 68/130 (52%), Gaps = 6/130 (4%) Frame = -2 Query: 410 EFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNILL-- 237 E++ GT+ L ++ L+WP+RL++A++ A+ L YLH + HRD+ + N L+ Sbjct: 125 EYMNGGTLEQLL----SSPEPLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRR 180 Query: 236 -DNSFHVKVADFGLSRLFPLEVTHVSTVP---QGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 D F V DFGL+ P+ P G+P ++ P + +K+DV G+ Sbjct: 181 EDGGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGI 240 Query: 68 VLVELISSKP 39 VL ELI+ P Sbjct: 241 VLCELIARVP 250
>M3K3_HUMAN (Q99759) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 66.2 bits (160), Expect = 4e-11 Identities = 46/143 (32%), Positives = 72/143 (50%), Gaps = 4/143 (2%) Frame = -2 Query: 455 YGCT-SRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 YGC R + L + E++ G+V D L A +T I E ++YLH Sbjct: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQIL----EGMSYLHSN 483 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFP---LEVTHVSTVPQGTPGYVDPVYHQCY 108 I+HRD+K NIL D++ +VK+ DFG S+ + T + +V GTP ++ P Sbjct: 484 MIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSV-TGTPYWMSPEVISGE 542 Query: 107 KLTDKSDVSTSGVVLVELISSKP 39 K+DV + G +VE+++ KP Sbjct: 543 GYGRKADVWSLGCTVVEMLTEKP 565
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 65.9 bits (159), Expect = 5e-11 Identities = 41/131 (31%), Positives = 73/131 (55%), Gaps = 2/131 (1%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE--IIHRDVK 255 ++ +V E++ G + D L + + +T+ +L + A + YLH I+HRD+K Sbjct: 1433 NICIVTEYMRMGNLRDVL---KNPDIKITFANKLKLLYGAAMGIDYLHSSNPMIVHRDIK 1489 Query: 254 TTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTS 75 NIL+D F+VK+ADFG +R ++ + + GTP + P + K +K+DV + Sbjct: 1490 PANILVDEHFNVKIADFGFAR---IKEDNTTMTRCGTPCWTAPEVIRGEKYCEKADVFSF 1546 Query: 74 GVVLVELISSK 42 GVV+ E+++ K Sbjct: 1547 GVVMWEVLTGK 1557 Score = 64.3 bits (155), Expect = 1e-10 Identities = 42/142 (29%), Positives = 82/142 (57%), Gaps = 3/142 (2%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V+L+ S S ++ +V EF++ G++ D L E + + L++ +A + ++ + +LH Sbjct: 843 VVLFMAASTKSPNMCIVMEFMSLGSLYDLLGNELIPE--IPYALKIKMAYQASKGMHFLH 900 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRL-FPLEVTHVSTVPQGTPGYVDPVYHQCY 108 I+HRD+K+ N+LLD+ ++VKV+DFGL+++ L+ + GT ++ P Sbjct: 901 SSGIVHRDLKSLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIAPEILNDS 960 Query: 107 KLTD--KSDVSTSGVVLVELIS 48 D +DV + G++L EL++ Sbjct: 961 TEVDYILADVYSFGIILWELLT 982
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 65.9 bits (159), Expect = 5e-11 Identities = 48/138 (34%), Positives = 81/138 (58%), Gaps = 3/138 (2%) Frame = -2 Query: 452 GCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE- 276 G S +D LL+ E++ G++ ++L+G E + +R A++ A+ALAYLH ++ Sbjct: 71 GRASNGKKDYLLM-EYLEEGSLHNYLYGDDKWEYTVEQAVRW--ALQCAKALAYLHSLDR 127 Query: 275 -IIHRDVKTTNILLDNSFH-VKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKL 102 I+HRD+K N+LL N +K+ DFGL+ ++++ T QGT Y+ P + K Sbjct: 128 PIVHRDIKPQNMLLYNQHEDLKICDFGLA----TDMSNNKTDMQGTLRYMAPEAIKHLKY 183 Query: 101 TDKSDVSTSGVVLVELIS 48 T K DV + G++L EL++ Sbjct: 184 TAKCDVYSFGIMLWELMT 201
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 65.9 bits (159), Expect = 5e-11 Identities = 52/157 (33%), Positives = 85/157 (54%), Gaps = 11/157 (7%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V +YG + L +V EF+ANG++ L + L W LR I ET+ A+ +LH Sbjct: 84 VSIYGVCKQ---PLGIVMEFMANGSLEKVL-----STHSLCWKLRFRIIHETSLAMNFLH 135 Query: 284 PVE--IIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVP----QGTPGYVDP- 126 ++ ++H D+K NILLD++ HVK++DFGLS+ + T + + +G Y+ P Sbjct: 136 SIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWME-QSTRMQYIERSALRGMLSYIPPE 194 Query: 125 VYHQCYKLT-DKSDVSTSGVVLVELISSK---PGVNM 27 ++ + K K DV + +V+ EL++ K G NM Sbjct: 195 MFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNM 231
>SGK3_MOUSE (Q9ERE3) Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) (Cytokine independent survival kinase) Length = 496 Score = 65.9 bits (159), Expect = 5e-11 Identities = 44/129 (34%), Positives = 64/129 (49%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L V +F+ G + HL ER P A E A AL YLH ++I++RD+K N Sbjct: 236 LYFVLDFVNGGELFFHLQ----RERSFPEPRARFYAAEIASALGYLHSIKIVYRDLKPEN 291 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 ILLD+ HV + DFGL + + ++ +T GTP Y+ P + + D G V Sbjct: 292 ILLDSMGHVVLTDFGLCK-EGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAV 350 Query: 65 LVELISSKP 39 L E++ P Sbjct: 351 LYEMLYGLP 359
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 65.5 bits (158), Expect = 7e-11 Identities = 48/155 (30%), Positives = 83/155 (53%), Gaps = 2/155 (1%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGL-TWPLRLNIAIETAEALAYL 288 V LYG + + LV+EF+ +G ++D+L ++RGL L + ++ E +AYL Sbjct: 424 VQLYGVCLEQA-PICLVFEFMEHGCLSDYLR----SQRGLFAAETLLGMCLDVCEGMAYL 478 Query: 287 HPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP-GYVDPVYHQC 111 +IHRD+ N L+ + +KV+DFG++R F L+ + S+ P + P Sbjct: 479 EKACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASPEVFSF 537 Query: 110 YKLTDKSDVSTSGVVLVELISSKPGVNMSRSHSEI 6 + + KSDV + GV++ E+ S +RS+SE+ Sbjct: 538 SRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEV 572
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 65.5 bits (158), Expect = 7e-11 Identities = 42/130 (32%), Positives = 67/130 (51%), Gaps = 6/130 (4%) Frame = -2 Query: 410 EFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNILL-- 237 E++ GT+ L ++ L+WP+RL++A++ A L YLH + HRD+ + N L+ Sbjct: 130 EYMNGGTLEQLL----SSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRR 185 Query: 236 -DNSFHVKVADFGLSRLFPLEVTHVSTVP---QGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 D F V DFGL+ P+ P G+P ++ P + +K+DV G+ Sbjct: 186 EDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGI 245 Query: 68 VLVELISSKP 39 VL ELI+ P Sbjct: 246 VLCELIARVP 255
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 65.5 bits (158), Expect = 7e-11 Identities = 45/140 (32%), Positives = 76/140 (54%), Gaps = 1/140 (0%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V YG S+ + +V E+I+NG + ++L R+ +GL L + + E +A+L Sbjct: 473 VKFYGVCSK-EYPIYIVTEYISNGCLLNYL---RSHGKGLEPSQLLEMCYDVCEGMAFLE 528 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP-GYVDPVYHQCY 108 + IHRD+ N L+D VKV+DFG++R + L+ +VS+V P + P + Sbjct: 529 SHQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAPEVFHYF 587 Query: 107 KLTDKSDVSTSGVVLVELIS 48 K + KSDV G+++ E+ S Sbjct: 588 KYSSKSDVWAFGILMWEVFS 607
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 65.1 bits (157), Expect = 9e-11 Identities = 48/155 (30%), Positives = 82/155 (52%), Gaps = 2/155 (1%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGL-TWPLRLNIAIETAEALAYL 288 V LYG + + LV+EF+ +G ++D+L +RGL L + ++ E +AYL Sbjct: 419 VQLYGVCLEQA-PICLVFEFMEHGCLSDYLR----TQRGLFAAETLLGMCLDVCEGMAYL 473 Query: 287 HPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP-GYVDPVYHQC 111 +IHRD+ N L+ + +KV+DFG++R F L+ + S+ P + P Sbjct: 474 EEACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASPEVFSF 532 Query: 110 YKLTDKSDVSTSGVVLVELISSKPGVNMSRSHSEI 6 + + KSDV + GV++ E+ S +RS+SE+ Sbjct: 533 SRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEV 567
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 65.1 bits (157), Expect = 9e-11 Identities = 43/136 (31%), Positives = 72/136 (52%), Gaps = 4/136 (2%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + +V EF+ +G++ + L + LT P +++A + AE +AY+ ++ IHRD++ N Sbjct: 353 IYIVTEFMCHGSLLEFLKDQEGQD--LTLPQLVDMAAQVAEGMAYMERMDYIHRDLRAAN 410 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 IL+ K+ADFGL+RL + + + P + T KSDV + G++ Sbjct: 411 ILVGERLVCKIADFGLARLIEDNEYNPRQGAKFPIKWTAPEAALFGRFTIKSDVWSFGIL 470 Query: 65 LVELISS----KPGVN 30 L ELIS PG+N Sbjct: 471 LTELISKGRVPYPGMN 486
>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)| (NimA-related protein kinase 8) Length = 697 Score = 65.1 bits (157), Expect = 9e-11 Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 1/129 (0%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L++ E+ GT+AD++ + L L+ ++ AL ++H I+HRD+KT N Sbjct: 76 LMIAMEYAPGGTLADYIQ--KRCNSLLDEDTILHSFVQILLALYHVHNKLILHRDLKTQN 133 Query: 245 ILLD-NSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 ILLD + VK+ DFG+S++ + + V GTP Y+ P + KSD+ G Sbjct: 134 ILLDKHQMIVKIGDFGISKILVSKSKAYTVV--GTPCYISPELCEGKPYNQKSDIWALGC 191 Query: 68 VLVELISSK 42 VL EL S K Sbjct: 192 VLYELASLK 200
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 64.7 bits (156), Expect = 1e-10 Identities = 42/133 (31%), Positives = 70/133 (52%), Gaps = 9/133 (6%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH---PVEIIHRDVKTT 249 L+Y ++ NGT+ D L C L W +R+ I I ++A+ YLH P +I + + Sbjct: 239 LIYPYMRNGTLFDRLQ-CVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSA 297 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPG------YVDPVYHQCYKLTDKSD 87 NILLD+ F K+ DF ++ F + H S T Y+ Y + KL+ K+D Sbjct: 298 NILLDDQFQPKLTDFAMAH-FRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTD 356 Query: 86 VSTSGVVLVELIS 48 V + G+V++E+++ Sbjct: 357 VYSFGIVIMEVLT 369
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 64.7 bits (156), Expect = 1e-10 Identities = 44/140 (31%), Positives = 76/140 (54%), Gaps = 1/140 (0%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V YG S+ + +V E+I NG + ++L ++ +GL L + + E +A+L Sbjct: 449 VKFYGVCSK-KYPIYIVTEYITNGCLLNYL---KSHGKGLESCQLLEMCYDVCEGMAFLE 504 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP-GYVDPVYHQCY 108 + IHRD+ N L+D+ VKV+DFG++R + L+ +VS+V P + P + Sbjct: 505 SHQFIHRDLAARNCLVDSDLSVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAPEVFHYF 563 Query: 107 KLTDKSDVSTSGVVLVELIS 48 K + KSDV G+++ E+ S Sbjct: 564 KYSSKSDVWAFGILMWEVFS 583
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 64.3 bits (155), Expect = 1e-10 Identities = 49/152 (32%), Positives = 78/152 (51%), Gaps = 7/152 (4%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY SR R + +V E+++ G++ L R L P +++A + A +AY+ Sbjct: 323 VQLYAVVSR--RPIYIVTEYMSKGSLLIFLKDGEG--RALKLPNLVDMAAQVAAGMAYIE 378 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + IHRD+++ NIL+ N K+ADFGL+RL + T QG + P Sbjct: 379 RMNYIHRDLRSANILVGNGLICKIADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 435 Query: 113 CYKLTDKSDVSTSGVVLVELISS----KPGVN 30 + T KSDV + G++L EL++ PG+N Sbjct: 436 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMN 467
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 64.3 bits (155), Expect = 1e-10 Identities = 48/152 (31%), Positives = 77/152 (50%), Gaps = 7/152 (4%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V E+++ G++ D L R L P +++A + A +AY+ Sbjct: 326 VQLYAVVSE--EPIYIVTEYMSKGSLLDFLKDGEG--RALKLPNLVDMAAQVARGMAYIE 381 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + IHRD+++ NIL+ N K+ADFGL+RL + T QG + P Sbjct: 382 RMNYIHRDLRSANILVGNGLICKIADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 438 Query: 113 CYKLTDKSDVSTSGVVLVELISS----KPGVN 30 + T KSDV + G++L EL++ PG+N Sbjct: 439 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMN 470
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 64.3 bits (155), Expect = 1e-10 Identities = 46/149 (30%), Positives = 75/149 (50%), Gaps = 4/149 (2%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V EF+ +G++ D L + L P +++A + AE +AY+ Sbjct: 319 VQLYAVVSE--EPIYIVTEFMCHGSLLDFLKNPEGQD--LRLPQLVDMAAQVAEGMAYME 374 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 + IHRD++ NIL+ K+ADFGL+RL + + + + P + Sbjct: 375 RMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGR 434 Query: 104 LTDKSDVSTSGVVLVELISS----KPGVN 30 T KSDV + G++L ELI+ PG+N Sbjct: 435 FTIKSDVWSFGILLTELITKGRIPYPGMN 463
>STE11_YEAST (P23561) Serine/threonine-protein kinase STE11 (EC 2.7.11.1)| Length = 738 Score = 63.9 bits (154), Expect = 2e-10 Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 2/143 (1%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 ++ Y S+ +L + E++ G+V+ L+ E L I I +AYLH Sbjct: 537 IVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYGPFEESLITNFTRQILI----GVAYLH 592 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLS-RLFPLEVTHVSTVP-QGTPGYVDPVYHQC 111 IIHRD+K NIL+D VK+ DFG+S +L PL QG+ ++ P + Sbjct: 593 KKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQ 652 Query: 110 YKLTDKSDVSTSGVVLVELISSK 42 T K+D+ ++G V++E+ + K Sbjct: 653 TATTAKADIWSTGCVVIEMFTGK 675
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 63.9 bits (154), Expect = 2e-10 Identities = 48/152 (31%), Positives = 77/152 (50%), Gaps = 7/152 (4%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V E+++ G++ D L R L P +++A + A +AY+ Sbjct: 323 VQLYAVVSE--EPIYIVTEYMSKGSLLDFLKDGEG--RALKLPNLVDMAAQVAAGMAYIE 378 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + IHRD+++ NIL+ N K+ADFGL+RL + T QG + P Sbjct: 379 RMNYIHRDLRSANILVGNGLICKIADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 435 Query: 113 CYKLTDKSDVSTSGVVLVELISS----KPGVN 30 + T KSDV + G++L EL++ PG+N Sbjct: 436 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMN 467
>SKM1_YEAST (Q12469) Serine/threonine-protein kinase SKM1 (EC 2.7.11.1)| (Protein kinase 75490 D) Length = 655 Score = 63.9 bits (154), Expect = 2e-10 Identities = 45/138 (32%), Positives = 73/138 (52%), Gaps = 8/138 (5%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGL-TWPLRLN----IAIETAEALAYLHPVEIIHR 264 +L ++ E++ G + D L + G + PL N I ET + L +LH +IIHR Sbjct: 447 ELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHR 506 Query: 263 DVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVST---VPQGTPGYVDPVYHQCYKLTDK 93 D+K+ NILL++ VK+ DFG F +E+T + GTP ++ P +K Sbjct: 507 DIKSDNILLNSQGLVKITDFG----FCVELTEKRSKRATMVGTPYWMAPEIVNQKGYDEK 562 Query: 92 SDVSTSGVVLVELISSKP 39 DV + G++L+E+I +P Sbjct: 563 VDVWSLGIMLIEMIEGEP 580
>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.11.1)| (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2) Length = 487 Score = 63.5 bits (153), Expect = 3e-10 Identities = 45/142 (31%), Positives = 71/142 (50%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V+ Y + + DL +V E+ G+V+D + R + LT I T + L YLH Sbjct: 85 VVKYYGSYFKNTDLWIVMEYCGAGSVSDII---RLRNKTLTEDEIATILQSTLKGLEYLH 141 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 + IHRD+K NILL+ H K+ADFG++ + +TV GTP ++ P Q Sbjct: 142 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTV-IGTPFWMAPEVIQEIG 200 Query: 104 LTDKSDVSTSGVVLVELISSKP 39 +D+ + G+ +E+ KP Sbjct: 201 YNCVADIWSLGITAIEMAEGKP 222
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 63.2 bits (152), Expect = 3e-10 Identities = 44/129 (34%), Positives = 71/129 (55%), Gaps = 3/129 (2%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE--IIHRDVKTTN 246 +V ++I+ G++ LH +R L +L IA++ A+ + YLH + IIHRD+ + N Sbjct: 536 IVTQYISGGSLFSLLH---EQKRILDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHN 592 Query: 245 ILLDNSFHVKVADFGLSR-LFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 ILL H VADFG SR L L+ +++ P V+ QC + T K+DV + + Sbjct: 593 ILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYSL 652 Query: 68 VLVELISSK 42 L EL++ + Sbjct: 653 CLWELLTGE 661
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 63.2 bits (152), Expect = 3e-10 Identities = 40/130 (30%), Positives = 70/130 (53%), Gaps = 3/130 (2%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 +V E++ T+ + LH + R L L + I +AL Y H I+HRD+K N++ Sbjct: 90 IVMEYVDGSTLRELLH----SGRKLLPERTLEMTIGILQALEYSHRAGIVHRDIKPANVM 145 Query: 239 LDNSFHVKVADFGLSRLF---PLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 L + VKV DFG++R + +T + V GT Y+ P + ++ +SD+ ++G Sbjct: 146 LTRNGQVKVMDFGIARAMGDSGMTMTQTAAV-IGTAQYLSPEQAKGEQVDARSDLYSTGC 204 Query: 68 VLVELISSKP 39 +L EL++ +P Sbjct: 205 LLYELLTVRP 214
>KPCD_HUMAN (Q05655) Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta)| Length = 676 Score = 63.2 bits (152), Expect = 3e-10 Identities = 45/134 (33%), Positives = 65/134 (48%), Gaps = 1/134 (0%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNI-AIETAEALAYLHPVEI 273 CT + L V EF+ G + H+ ++G R A E L +LH I Sbjct: 415 CTFQTKDHLFFVMEFLNGGDLMYHIQ-----DKGRFELYRATFYAAEIMCGLQFLHSKGI 469 Query: 272 IHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDK 93 I+RD+K N+LLD H+K+ADFG+ + + ST GTP Y+ P Q K T Sbjct: 470 IYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTF-CGTPDYIAPEILQGLKYTFS 528 Query: 92 SDVSTSGVVLVELI 51 D + GV+L E++ Sbjct: 529 VDWWSFGVLLYEML 542
>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) Length = 698 Score = 63.2 bits (152), Expect = 3e-10 Identities = 43/129 (33%), Positives = 67/129 (51%), Gaps = 1/129 (0%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L++ E+ GT+A+ + + L L+ ++ AL ++H I+HRD+KT N Sbjct: 76 LMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQN 133 Query: 245 ILLD-NSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 ILLD + VK+ DFG+S++ + + V GTP Y+ P + KSD+ G Sbjct: 134 ILLDKHRMVVKIGDFGISKILSSKSKAYTVV--GTPCYISPELCEGKPYNQKSDIWALGC 191 Query: 68 VLVELISSK 42 VL EL S K Sbjct: 192 VLYELASLK 200
>KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC 2.7.11.11) (PKA| 3) Length = 398 Score = 63.2 bits (152), Expect = 3e-10 Identities = 43/133 (32%), Positives = 70/133 (52%) Frame = -2 Query: 446 TSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIH 267 T + S+ + +V ++I G + L R ++R P+ A E AL YLH +II+ Sbjct: 154 TFQDSQQVFMVMDYIEGGELFSLL---RKSQR-FPNPVAKFYAAEVCLALEYLHSKDIIY 209 Query: 266 RDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSD 87 RD+K NILLD + H+K+ DFG ++ P +VT+ GTP Y+ P D Sbjct: 210 RDLKPENILLDKNGHIKITDFGFAKYVP-DVTYTLC---GTPDYIAPEVVSTKPYNKSVD 265 Query: 86 VSTSGVVLVELIS 48 + GV++ E+++ Sbjct: 266 WWSFGVLIYEMLA 278
>STK3_MOUSE (Q9JI10) Serine/threonine-protein kinase 3 (EC 2.7.11.1)| (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) Length = 497 Score = 63.2 bits (152), Expect = 3e-10 Identities = 45/142 (31%), Positives = 71/142 (50%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V+ Y + + DL +V E+ G+V+D + R + LT I T + L YLH Sbjct: 82 VVKYYGSYFKNTDLWIVMEYCGAGSVSDII---RLRNKTLTEDEIATILKSTLKGLEYLH 138 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 + IHRD+K NILL+ H K+ADFG++ + +TV GTP ++ P Q Sbjct: 139 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTV-IGTPFWMAPEVIQEIG 197 Query: 104 LTDKSDVSTSGVVLVELISSKP 39 +D+ + G+ +E+ KP Sbjct: 198 YNCVADIWSLGITSIEMAEGKP 219
>KPCT_HUMAN (Q04759) Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)| Length = 706 Score = 63.2 bits (152), Expect = 3e-10 Identities = 41/133 (30%), Positives = 62/133 (46%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEII 270 CT + +L V E++ G + H+ C + A E L +LH I+ Sbjct: 446 CTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRA----TFYAAEIILGLQFLHSKGIV 501 Query: 269 HRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKS 90 +RD+K NILLD H+K+ADFG+ + L +T GTP Y+ P K Sbjct: 502 YRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTF-CGTPDYIAPEILLGQKYNHSV 560 Query: 89 DVSTSGVVLVELI 51 D + GV+L E++ Sbjct: 561 DWWSFGVLLYEML 573
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 63.2 bits (152), Expect = 3e-10 Identities = 49/141 (34%), Positives = 77/141 (54%), Gaps = 2/141 (1%) Frame = -2 Query: 464 VILYG-CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYL 288 V LYG CT + R + ++ E++ANG + ++L R R T L L + + EA+ YL Sbjct: 457 VQLYGVCTKQ--RPIFIITEYMANGCLLNYLREMR--HRFQTQQL-LEMCKDVCEAMEYL 511 Query: 287 HPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCY 108 + +HRD+ N L+++ VKV+DFGLSR + L+ + S+V P P Y Sbjct: 512 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVLMY 570 Query: 107 -KLTDKSDVSTSGVVLVELIS 48 K + KSD+ GV++ E+ S Sbjct: 571 SKFSSKSDIWAFGVLMWEIYS 591
>BTK_HUMAN (Q06187) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 658 Score = 63.2 bits (152), Expect = 3e-10 Identities = 49/141 (34%), Positives = 77/141 (54%), Gaps = 2/141 (1%) Frame = -2 Query: 464 VILYG-CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYL 288 V LYG CT + R + ++ E++ANG + ++L R R T L L + + EA+ YL Sbjct: 457 VQLYGVCTKQ--RPIFIITEYMANGCLLNYLREMR--HRFQTQQL-LEMCKDVCEAMEYL 511 Query: 287 HPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCY 108 + +HRD+ N L+++ VKV+DFGLSR + L+ + S+V P P Y Sbjct: 512 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVLMY 570 Query: 107 -KLTDKSDVSTSGVVLVELIS 48 K + KSD+ GV++ E+ S Sbjct: 571 SKFSSKSDIWAFGVLMWEIYS 591
>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a) Length = 692 Score = 63.2 bits (152), Expect = 3e-10 Identities = 43/129 (33%), Positives = 67/129 (51%), Gaps = 1/129 (0%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L++ E+ GT+A+ + + L L+ ++ AL ++H I+HRD+KT N Sbjct: 76 LMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQN 133 Query: 245 ILLD-NSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 ILLD + VK+ DFG+S++ + + V GTP Y+ P + KSD+ G Sbjct: 134 ILLDKHRMVVKIGDFGISKILSSKSKAYTVV--GTPCYISPELCEGKPYNQKSDIWALGC 191 Query: 68 VLVELISSK 42 VL EL S K Sbjct: 192 VLYELASLK 200
>PKN1_CORGL (Q8NU98) Probable serine/threonine protein kinase pknB (EC| 2.7.11.1) Length = 646 Score = 62.8 bits (151), Expect = 4e-10 Identities = 42/110 (38%), Positives = 58/110 (52%), Gaps = 4/110 (3%) Frame = -2 Query: 356 ERGLTWPLRL-NIAIETAEALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLF-- 186 E G+ P+ NI I EAL H IIHRDVK NI++ N+ VKV DFG++R Sbjct: 104 EDGVFTPVEAANILIPVCEALQASHDAGIIHRDVKPANIMITNTGGVKVMDFGIARAVND 163 Query: 185 -PLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLVELISSKP 39 +T S V GT Y+ P + +SD+ +G V+ EL++ KP Sbjct: 164 STSAMTQTSAV-IGTAQYLSPEQARGKPADARSDIYATGCVMYELVTGKP 212
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 62.8 bits (151), Expect = 4e-10 Identities = 48/152 (31%), Positives = 76/152 (50%), Gaps = 7/152 (4%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V E++ G++ D L R L P +++A + A +AY+ Sbjct: 326 VQLYAVVSE--EPIYIVTEYMNKGSLLDFLKDGEG--RALKLPNLVDMAAQVAAGMAYIE 381 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + IHRD+++ NIL+ N K+ADFGL+RL + T QG + P Sbjct: 382 RMNYIHRDLRSANILVGNGLICKIADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 438 Query: 113 CYKLTDKSDVSTSGVVLVELISS----KPGVN 30 + T KSDV + G++L EL++ PG+N Sbjct: 439 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMN 470
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 62.8 bits (151), Expect = 4e-10 Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 7/152 (4%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V EF++ G++ D L R L P +++A + A +AY+ Sbjct: 325 VQLYAVVSE--EPIYIVTEFMSQGSLLDFLKD--GDGRYLKLPQLVDMAAQIAAGMAYIE 380 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + IHRD++ NIL+ ++ K+ADFGL+RL + T QG + P Sbjct: 381 RMNYIHRDLRAANILVGDNLVCKIADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 437 Query: 113 CYKLTDKSDVSTSGVVLVELISS----KPGVN 30 K T KSDV + G++L EL++ PG+N Sbjct: 438 FGKFTIKSDVWSFGILLTELVTKGRVPYPGMN 469
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 62.8 bits (151), Expect = 4e-10 Identities = 35/88 (39%), Positives = 50/88 (56%) Frame = -2 Query: 302 ALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPV 123 AL YLH I+HRD+K N+LLD + H K+ DFGL+R L THV T +GTP Y+ P Sbjct: 112 ALYYLHSNRILHRDLKPQNVLLDKNMHAKLCDFGLARNMTLG-THVLTSIKGTPLYMAPE 170 Query: 122 YHQCYKLTDKSDVSTSGVVLVELISSKP 39 +D+ + G + E ++ +P Sbjct: 171 LLAEQPYDHHADMWSLGCIAYESMAGQP 198
>KPC1_CAEEL (P34722) Protein kinase C-like 1 (EC 2.7.11.13) (PKC)| (Tetradecanoyl phorbol acetate resistant protein 1) Length = 704 Score = 62.8 bits (151), Expect = 4e-10 Identities = 41/147 (27%), Positives = 70/147 (47%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEII 270 C+ + + L V E++ G + H+ + + T A E AL +LH II Sbjct: 441 CSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEART----RFYACEIVVALQFLHTNNII 496 Query: 269 HRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKS 90 +RD+K N+LLD H+K+ADFG+++ +++ GTP Y+ P + + Sbjct: 497 YRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAV 556 Query: 89 DVSTSGVVLVELISSKPGVNMSRSHSE 9 D + GV++ E++ V S H E Sbjct: 557 DFWSFGVLMYEML-----VGQSPFHGE 578
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 62.4 bits (150), Expect = 6e-10 Identities = 47/152 (30%), Positives = 78/152 (51%), Gaps = 7/152 (4%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V E+++ G++ D L R L P +++A + A +AY+ Sbjct: 326 VQLYAVVSE--EPIYIVTEYMSKGSLLDFLKDGEG--RALKLPNLVDMAAQVAAGMAYIE 381 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + IHRD+++ NIL+ ++ K+ADFGL+RL + T QG + P Sbjct: 382 RMNYIHRDLRSANILVGDNLVCKIADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 438 Query: 113 CYKLTDKSDVSTSGVVLVELISS----KPGVN 30 + T KSDV + G++L EL++ PG+N Sbjct: 439 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMN 470
>KPCT_MOUSE (Q02111) Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)| Length = 707 Score = 62.4 bits (150), Expect = 6e-10 Identities = 40/133 (30%), Positives = 62/133 (46%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEII 270 CT + +L V E++ G + H+ C + A E L +LH I+ Sbjct: 446 CTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRA----TFYAAEVILGLQFLHSKGIV 501 Query: 269 HRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKS 90 +RD+K NILLD H+K+ADFG+ + L +T GTP Y+ P K Sbjct: 502 YRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTF-CGTPDYIAPEILLGQKYNHSV 560 Query: 89 DVSTSGVVLVELI 51 D + GV++ E++ Sbjct: 561 DWWSFGVLVYEML 573
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 62.4 bits (150), Expect = 6e-10 Identities = 46/138 (33%), Positives = 66/138 (47%), Gaps = 4/138 (2%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHL--HGCRAAERGLTWPLRLNIAIETAEALAYLHPVE 276 C + + L LV E++ G++ D+L H A+ L A + E +AYLH Sbjct: 966 CEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQL-------LLFAQQICEGMAYLHAQH 1018 Query: 275 IIHRDVKTTNILLDNSFHVKVADFGLSRLFP--LEVTHVSTVPQGTPGYVDPVYHQCYKL 102 IHRD+ N+LLDN VK+ DFGL++ P E V + P + YK Sbjct: 1019 YIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKF 1078 Query: 101 TDKSDVSTSGVVLVELIS 48 SDV + GV L EL++ Sbjct: 1079 YYASDVWSFGVTLYELLT 1096
>KPC2_DROME (P13677) Protein kinase C, eye isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(EY)) (Protein INAC) (Inactivation no after-potential C protein) (Photoreceptor-specific PKC) (Eye-PKC) Length = 700 Score = 62.4 bits (150), Expect = 6e-10 Identities = 46/141 (32%), Positives = 69/141 (48%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V ++ C M R L V E+ G + H+ + + + A+E A AL +LH Sbjct: 433 VSMHSCFQTMDR-LFFVMEYCKGGDLMYHMQQYGRFKESVA----IFYAVEVAIALFFLH 487 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 +II+RD+K NILLD HVK+ DFGLS+ E T GTP Y+ P Sbjct: 488 ERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTF-CGTPNYMAPEIVSYDP 546 Query: 104 LTDKSDVSTSGVVLVELISSK 42 + +D + GV+L E ++ + Sbjct: 547 YSIAADWWSFGVLLFEFMAGQ 567
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 62.4 bits (150), Expect = 6e-10 Identities = 44/126 (34%), Positives = 69/126 (54%), Gaps = 3/126 (2%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE--IIHRDVKTTN 246 +V ++I+ G++ LH +R L +L IA++ A+ + YLH + IIHRD+ + N Sbjct: 535 IVTQYISGGSLFSLLH---EQKRILDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHN 591 Query: 245 ILLDNSFHVKVADFGLSR-LFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 ILL H VADFG SR L L+ +++ P V+ QC + T K+DV + + Sbjct: 592 ILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYAL 651 Query: 68 VLVELI 51 L EL+ Sbjct: 652 CLWELL 657
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 62.0 bits (149), Expect = 7e-10 Identities = 42/131 (32%), Positives = 74/131 (56%), Gaps = 7/131 (5%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGL----TWPLRLNIAIETAEALAYLH---PVEIIHRD 261 +V E+ + G++ D+++ R+ E + TW A + A+ + YLH PV++IHRD Sbjct: 80 IVTEYASLGSLYDYINSNRSEEMDMEHIMTW------ATDVAKGMHYLHMEAPVKVIHRD 133 Query: 260 VKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVS 81 +K+ N+++ +K+ DFG SR F TH+S V GT ++ P Q +++ D Sbjct: 134 LKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLV--GTFPWMAPEVIQSLPVSETCDTY 190 Query: 80 TSGVVLVELIS 48 + GVVL E+++ Sbjct: 191 SYGVVLWEMLT 201
>PKN2_COREF (Q8FUI4) Serine/threonine protein kinases drp72 (EC 2.7.11.1)| Length = 520 Score = 62.0 bits (149), Expect = 7e-10 Identities = 38/126 (30%), Positives = 68/126 (53%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 +V E+I ++AD L E L L L++ + A L+ +H + ++HRD+K N+L Sbjct: 100 IVLEYIRGESLADMLE----REGALPEELALDVMEQAAHGLSVIHRMGLVHRDIKPGNML 155 Query: 239 LDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLV 60 + + +K+ DFG+++ + + GT YV P Q +++T SDV + GVV Sbjct: 156 ITANGILKITDFGIAKAAASVPLTRTGMVVGTAQYVSPEQAQGHQVTPASDVYSLGVVGY 215 Query: 59 ELISSK 42 E++S + Sbjct: 216 EMLSGR 221
>GAD8_SCHPO (Q9P7J8) Serine/threonine-protein kinase gad8 (EC 2.7.11.1)| Length = 569 Score = 62.0 bits (149), Expect = 7e-10 Identities = 45/131 (34%), Positives = 64/131 (48%), Gaps = 2/131 (1%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLH--GCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKT 252 L LV F+ G + HL GC R + L +A+E LH +I+RD+K Sbjct: 303 LYLVLAFVNGGELFHHLQREGCFDTYRAKFYIAELLVALEC------LHEFNVIYRDLKP 356 Query: 251 TNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSG 72 NILLD + H+ + DFGL +L + +T GTP Y+ P + T D T G Sbjct: 357 ENILLDYTGHIALCDFGLCKLNMAKTDRTNTF-CGTPEYLAPELLLGHGYTKVVDWWTLG 415 Query: 71 VVLVELISSKP 39 V+L E+I+ P Sbjct: 416 VLLYEMITGLP 426
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 62.0 bits (149), Expect = 7e-10 Identities = 44/133 (33%), Positives = 68/133 (51%) Frame = -2 Query: 446 TSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIH 267 T + +R++ +V ++I G + L R ++R P+ A E AL YLH II+ Sbjct: 136 TFQDARNIFMVMDYIEGGELFSLL---RKSQR-FPNPVAKFYAAEVILALEYLHAHNIIY 191 Query: 266 RDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSD 87 RD+K NILLD + H+K+ DFG F EV V+ GTP Y+ P D Sbjct: 192 RDLKPENILLDRNGHIKITDFG----FAKEVQTVTWTLCGTPDYIAPEVITTKPYNKSVD 247 Query: 86 VSTSGVVLVELIS 48 + GV++ E+++ Sbjct: 248 WWSLGVLIYEMLA 260
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 62.0 bits (149), Expect = 7e-10 Identities = 40/144 (27%), Positives = 70/144 (48%), Gaps = 10/144 (6%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEII 270 CT +L++ E++ NG++ ++L + L +++ E +E +AYL +++ Sbjct: 282 CTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQ--MVHMMAEISEGMAYLESEKVV 339 Query: 269 HRDVKTTNILLDNSFHVKVADFGLSRLF----------PLEVTHVSTVPQGTPGYVDPVY 120 HRD++ NIL+ N KVADFGL+ L L + T P+ V Sbjct: 340 HRDLRADNILVANDLTRKVADFGLTELTDGSLGDQEKKTLRFPYKWTAPEAAKSKV---- 395 Query: 119 HQCYKLTDKSDVSTSGVVLVELIS 48 T KSDV + G+V+ E+++ Sbjct: 396 -----FTSKSDVWSYGIVMFEILT 414
>SGK3_HUMAN (Q96BR1) Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) Length = 496 Score = 62.0 bits (149), Expect = 7e-10 Identities = 43/129 (33%), Positives = 63/129 (48%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L V +F+ G + HL ER A E A AL YLH ++I++RD+K N Sbjct: 236 LYFVLDFVNGGELFFHLQ----RERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPEN 291 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 ILLD+ HV + DFGL + + ++ +T GTP Y+ P + + D G V Sbjct: 292 ILLDSVGHVVLTDFGLCK-EGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAV 350 Query: 65 LVELISSKP 39 L E++ P Sbjct: 351 LYEMLYGLP 359
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 62.0 bits (149), Expect = 7e-10 Identities = 37/134 (27%), Positives = 67/134 (50%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEII 270 CT + + ++ E + +G++ ++L R L +++A + A +AYL I Sbjct: 310 CT--VEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYI 367 Query: 269 HRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKS 90 HRD+ N+L+ + VK+ADFGL+RL + + + P K + KS Sbjct: 368 HRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKS 427 Query: 89 DVSTSGVVLVELIS 48 DV + G++L EL++ Sbjct: 428 DVWSFGILLTELVT 441
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 62.0 bits (149), Expect = 7e-10 Identities = 42/131 (32%), Positives = 74/131 (56%), Gaps = 7/131 (5%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGL----TWPLRLNIAIETAEALAYLH---PVEIIHRD 261 +V E+ + G++ D+++ R+ E + TW A + A+ + YLH PV++IHRD Sbjct: 80 IVTEYASLGSLYDYINSNRSEEMDMDHIMTW------ATDVAKGMHYLHMEAPVKVIHRD 133 Query: 260 VKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVS 81 +K+ N+++ +K+ DFG SR F TH+S V GT ++ P Q +++ D Sbjct: 134 LKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLV--GTFPWMAPEVIQSLPVSETCDTY 190 Query: 80 TSGVVLVELIS 48 + GVVL E+++ Sbjct: 191 SYGVVLWEMLT 201
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 62.0 bits (149), Expect = 7e-10 Identities = 43/129 (33%), Positives = 71/129 (55%), Gaps = 3/129 (2%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE--IIHRDVKTTN 246 +V ++I+ G++ LH +R L +L IA++ A+ + YLH + IIHRD+ + N Sbjct: 638 IVTQYISGGSLFSLLH---EQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHN 694 Query: 245 ILLDNSFHVKVADFGLSR-LFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 ILL H VADFG SR L L+ +++ P V+ QC + T K+DV + + Sbjct: 695 ILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYAL 754 Query: 68 VLVELISSK 42 L E+++ + Sbjct: 755 CLWEILTGE 763
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 61.6 bits (148), Expect = 1e-09 Identities = 44/141 (31%), Positives = 69/141 (48%), Gaps = 9/141 (6%) Frame = -2 Query: 437 MSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDV 258 M+ + LV E+ G +AD+LH R +RL + + A A+ LH IIHRD+ Sbjct: 84 MANSVYLVMEYCNGGDLADYLHAMRTLSEDT---IRLFLQ-QIAGAMRLLHSKGIIHRDL 139 Query: 257 KTTNILLD---------NSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 K NILL NS VK+ADFG +R L+ ++ G+P Y+ P Sbjct: 140 KPQNILLSNPAGRRANPNSIRVKIADFGFARY--LQSNMMAATLCGSPMYMAPEVIMSQH 197 Query: 104 LTDKSDVSTSGVVLVELISSK 42 K+D+ + G ++ + ++ K Sbjct: 198 YDGKADLWSIGTIVYQCLTGK 218
>SGK1_HUMAN (O00141) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 61.6 bits (148), Expect = 1e-09 Identities = 48/133 (36%), Positives = 65/133 (48%), Gaps = 4/133 (3%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L V ++I G + HL ER P A E A AL YLH + I++RD+K N Sbjct: 172 LYFVLDYINGGELFYHLQ----RERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPEN 227 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQ--GTPGYVDP--VYHQCYKLTDKSDVST 78 ILLD+ H+ + DFGL + + H ST GTP Y+ P ++ Q Y T D Sbjct: 228 ILLDSQGHIVLTDFGLCK---ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRT--VDWWC 282 Query: 77 SGVVLVELISSKP 39 G VL E++ P Sbjct: 283 LGAVLYEMLYGLP 295
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 61.6 bits (148), Expect = 1e-09 Identities = 47/141 (33%), Positives = 76/141 (53%), Gaps = 2/141 (1%) Frame = -2 Query: 464 VILYG-CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYL 288 V LYG CT + R + ++ E++ANG + + L R +R L + + EA+ YL Sbjct: 456 VQLYGVCTKQ--RPIFIITEYMANGCLLNFL---RETQRRFQPAELLEMCKDVCEAMEYL 510 Query: 287 HPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCY 108 + +HRD+ N L+++ VKV+DFGLSR + L+ + S++ P P Y Sbjct: 511 ESKQFLHRDLAARNCLVNDQGIVKVSDFGLSR-YVLDDEYTSSMGSKFPVRWSPPEVLLY 569 Query: 107 -KLTDKSDVSTSGVVLVELIS 48 K + KSDV + GV++ E+ S Sbjct: 570 SKFSSKSDVWSFGVLMWEVYS 590
>PAK1_CAEEL (Q17850) Serine/threonine-protein kinase pak-1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK1) (CePAK) Length = 572 Score = 61.6 bits (148), Expect = 1e-09 Identities = 40/131 (30%), Positives = 70/131 (53%), Gaps = 1/131 (0%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++A G++ D + C+ + + R E +AL +LH +IHRD+K+ Sbjct: 364 ELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCR-----EVLQALEFLHSRHVIHRDIKSD 418 Query: 248 NILLDNSFHVKVADFGL-SRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSG 72 NILL VK+ DFG ++L P + + V GTP ++ P + K DV + G Sbjct: 419 NILLGMDGSVKLTDFGFCAQLSPEQRKRTTMV--GTPYWMAPEVVTRKQYGPKVDVWSLG 476 Query: 71 VVLVELISSKP 39 ++ +E++ +P Sbjct: 477 IMAIEMVEGEP 487
>KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC 2.7.11.11) (PKA| 1) (CDC25-suppressing protein kinase) (PK-25) Length = 397 Score = 61.6 bits (148), Expect = 1e-09 Identities = 40/133 (30%), Positives = 70/133 (52%) Frame = -2 Query: 446 TSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIH 267 T + ++ + ++ ++I G + L R ++R P+ A E AL YLH +II+ Sbjct: 153 TFQDAQQIFMIMDYIEGGELFSLL---RKSQR-FPNPVAKFYAAEVCLALEYLHSKDIIY 208 Query: 266 RDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSD 87 RD+K NILLD + H+K+ DFG ++ P +VT+ GTP Y+ P D Sbjct: 209 RDLKPENILLDKNGHIKITDFGFAKYVP-DVTYTLC---GTPDYIAPEVVSTKPYNKSID 264 Query: 86 VSTSGVVLVELIS 48 + G+++ E+++ Sbjct: 265 WWSFGILIYEMLA 277
>AKL1_YEAST (P38080) Serine/threonine-protein kinase AKL1 (EC 2.7.11.1)| Length = 1108 Score = 61.6 bits (148), Expect = 1e-09 Identities = 44/141 (31%), Positives = 75/141 (53%), Gaps = 15/141 (10%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH--PVEIIHRDVK 255 ++LL+ E N ++ D+++ + LT + I + A +++ +H PV +IHRD+K Sbjct: 126 EVLLLMELCPNKSLLDYMN--QRLSTKLTEAEIVKIMYDVALSISQMHYLPVSLIHRDIK 183 Query: 254 TTNILLDNSFHVKVADFG-LSRLFPLEVTH-----------VSTVPQ-GTPGYVDPVYHQ 114 N+L+D + K+ADFG S FP+ TH V T PQ +P +D ++ Sbjct: 184 IENVLVDAKNNFKLADFGSTSTCFPIVTTHQDIALLTQNIYVHTTPQYRSPEMID--LYR 241 Query: 113 CYKLTDKSDVSTSGVVLVELI 51 C + +KSD+ GV L +L+ Sbjct: 242 CLPINEKSDIWALGVFLYKLL 262
>RIPK3_MOUSE (Q9QZL0) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) Length = 486 Score = 61.6 bits (148), Expect = 1e-09 Identities = 47/154 (30%), Positives = 76/154 (49%), Gaps = 13/154 (8%) Frame = -2 Query: 464 VILYGCTSRMSRDLL----LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEAL 297 ++L G T + D + LV F+ NG++A G E WPL + E + Sbjct: 74 LLLLGVTEDLQWDFVSGQALVTRFMENGSLA----GLLQPECPRPWPLLCRLLQEVVLGM 129 Query: 296 AYLHPVE--IIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVT-----HVSTVPQGTPG 138 YLH ++ ++HRD+K +NILLD H K+ADFGLS + S GT Sbjct: 130 CYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLA 189 Query: 137 YVDP--VYHQCYKLTDKSDVSTSGVVLVELISSK 42 Y+DP ++ K + SDV + G+++ +++ + Sbjct: 190 YLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 61.2 bits (147), Expect = 1e-09 Identities = 43/137 (31%), Positives = 69/137 (50%), Gaps = 4/137 (2%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 ++ EF+ G + D+L C E ++ + L +A + + A+ YL IHRD+ N L Sbjct: 313 IITEFMTYGNLLDYLRECNRQE--VSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 370 Query: 239 LDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLV 60 + + VKVADFGLSRL + + + P K + KSDV GV+L Sbjct: 371 VGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLW 430 Query: 59 EL----ISSKPGVNMSR 21 E+ +S PG+++S+ Sbjct: 431 EIATYGMSPYPGIDLSQ 447
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 61.2 bits (147), Expect = 1e-09 Identities = 43/137 (31%), Positives = 69/137 (50%), Gaps = 4/137 (2%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 ++ EF+ G + D+L C E ++ + L +A + + A+ YL IHRD+ N L Sbjct: 199 IITEFMTYGNLLDYLRECNRQE--VSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 256 Query: 239 LDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLV 60 + + VKVADFGLSRL + + + P K + KSDV GV+L Sbjct: 257 VGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLW 316 Query: 59 EL----ISSKPGVNMSR 21 E+ +S PG+++S+ Sbjct: 317 EIATYGMSPYPGIDLSQ 333
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 61.2 bits (147), Expect = 1e-09 Identities = 46/140 (32%), Positives = 71/140 (50%), Gaps = 3/140 (2%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V E+I+ G++ D L G R L P +++A + A +AY+ Sbjct: 321 VQLYAVVSE--EPIYIVTEYISKGSLLDFLKG--EMGRYLRLPQLVDMAAQIASGMAYVE 376 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + +HRD++ NIL+ + KVADFGL+RL + T QG + P Sbjct: 377 RMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 433 Query: 113 CYKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 434 YGRFTIKSDVWSFGILLTEL 453
>PLO1_SCHPO (P50528) Serine/threonine-protein kinase plo1 (EC 2.7.11.21)| Length = 683 Score = 61.2 bits (147), Expect = 1e-09 Identities = 41/134 (30%), Positives = 72/134 (53%), Gaps = 2/134 (1%) Frame = -2 Query: 434 SRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVK 255 S ++ L+ E + ++ + L + LT P + ++ AL Y+H +IHRD+K Sbjct: 110 STNIYLILELCEHKSLMELLR----KRKQLTEPEVRYLMMQILGALKYMHKKRVIHRDLK 165 Query: 254 TTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDP--VYHQCYKLTDKSDVS 81 NI+LD S +VK+ DFGL+ L + T+ GTP Y+ P +++ + + D+ Sbjct: 166 LGNIMLDESNNVKIGDFGLAALLMDDEERKMTI-CGTPNYIAPEILFNSKEGHSFEVDLW 224 Query: 80 TSGVVLVELISSKP 39 ++GVV+ L+ KP Sbjct: 225 SAGVVMYALLIGKP 238
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 61.2 bits (147), Expect = 1e-09 Identities = 46/149 (30%), Positives = 73/149 (48%), Gaps = 4/149 (2%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V EF+ G++ D L + L P +++A + AE +AY+ Sbjct: 307 VQLYAVVSE--EPIYIVTEFMCYGSLLDFLKDREG--QNLMLPHLVDMAAQVAEGMAYME 362 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 + IHRD++ NIL+ K+ADFGL+RL + + + P + Sbjct: 363 RMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPIKWTAPEAALFGR 422 Query: 104 LTDKSDVSTSGVVLVELISS----KPGVN 30 T KSDV + G++L ELI+ PG+N Sbjct: 423 FTVKSDVWSFGILLTELITKGRVPYPGMN 451
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 61.2 bits (147), Expect = 1e-09 Identities = 45/144 (31%), Positives = 73/144 (50%), Gaps = 7/144 (4%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++ G + D L + + PL + E L +LH + HRD+K Sbjct: 243 ELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLL----ETLLHLHKQGVTHRDIKPE 298 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT------DKSD 87 NIL+ N FH+K++DFGL+++ T + T GT GY+ P + + DK D Sbjct: 299 NILITNDFHLKISDFGLAKVIHGTGTFLETF-CGTMGYLAPEVLKSKNVNLDGGYDDKVD 357 Query: 86 VSTSGVVL-VELISSKPGVNMSRS 18 + + G VL V L +S P + S++ Sbjct: 358 IWSLGCVLYVMLTASIPFASSSQA 381
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 60.8 bits (146), Expect = 2e-09 Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 3/142 (2%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V EF+ G++ D L + L P +++A + A+ +AY+ Sbjct: 323 VPLYAVVSE--EPIYIVTEFMTKGSLLDFLK--EGEGKFLKLPQLVDMAAQIADGMAYIE 378 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + IHRD++ NIL+ ++ K+ADFGL+RL + T QG + P Sbjct: 379 RMNYIHRDLRAANILVGDNLVCKIADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 435 Query: 113 CYKLTDKSDVSTSGVVLVELIS 48 + T KSDV + G++L EL++ Sbjct: 436 YGRFTIKSDVWSFGILLTELVT 457
>JAK3_MOUSE (Q62137) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3)| (JAK-3) Length = 1299 Score = 60.8 bits (146), Expect = 2e-09 Identities = 45/133 (33%), Positives = 68/133 (51%), Gaps = 5/133 (3%) Frame = -2 Query: 431 RDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKT 252 + L LV E++ +G + D L RAA L L A + + + YL +HRD+ Sbjct: 1105 QSLRLVMEYLPSGCLRDFLQRHRAA---LHTDRLLLFAWQICKGMEYLGARRCVHRDLAA 1161 Query: 251 TNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD-----KSD 87 NIL+++ HVK+ADFGL++L PL + PG ++ L+D +SD Sbjct: 1162 RNILVESEAHVKIADFGLAKLLPLGKDYYVV---REPGQSPIFWYAPESLSDNIFSRQSD 1218 Query: 86 VSTSGVVLVELIS 48 V + GVVL EL + Sbjct: 1219 VWSFGVVLYELFT 1231
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 60.8 bits (146), Expect = 2e-09 Identities = 46/149 (30%), Positives = 77/149 (51%), Gaps = 8/149 (5%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHG----CRAAERGLTWPLRLNIAIETAEAL 297 + L+G +S L++ EF G++ + LHG + ++W A + AE L Sbjct: 73 IALHGISSYQQATYLIM-EFAEGGSLHNFLHGKVKPAYSLAHAMSW------ARQCAEGL 125 Query: 296 AYLH---PVEIIHRDVKTTNILLDN-SFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVD 129 AYLH P +IHRDVK N+LL N ++K+ DFG + + + T +G+ ++ Sbjct: 126 AYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGT----VADKSTMMTNNRGSAAWMA 181 Query: 128 PVYHQCYKLTDKSDVSTSGVVLVELISSK 42 P + K T+K D+ + +VL E++S K Sbjct: 182 PEVFEGSKYTEKCDIFSWAIVLWEVLSRK 210
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 60.8 bits (146), Expect = 2e-09 Identities = 43/137 (31%), Positives = 67/137 (48%), Gaps = 4/137 (2%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 ++ EF+ G + D+L C E + L +A + + A+ YL IHRD+ N L Sbjct: 313 IITEFMTYGNLLDYLRECNRQEVNAV--VLLYMATQISSAMEYLEKKNFIHRDLAARNCL 370 Query: 239 LDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLV 60 + + VKVADFGLSRL + + + P K + KSDV GV+L Sbjct: 371 VGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLW 430 Query: 59 EL----ISSKPGVNMSR 21 E+ +S PG+++S+ Sbjct: 431 EIATYGMSPYPGIDLSQ 447
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 60.8 bits (146), Expect = 2e-09 Identities = 42/138 (30%), Positives = 67/138 (48%), Gaps = 13/138 (9%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L + E+I GT+ + ++ + W R++ A + A +AYLH + IIHRD+ + N Sbjct: 409 LNFITEYIKGGTLRGII---KSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHN 465 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQ-------------GTPGYVDPVYHQCYK 105 L+ + +V VADFGL+RL E T + G P ++ P Sbjct: 466 CLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRS 525 Query: 104 LTDKSDVSTSGVVLVELI 51 +K DV + G+VL E+I Sbjct: 526 YDEKVDVFSFGIVLCEII 543
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 60.8 bits (146), Expect = 2e-09 Identities = 44/142 (30%), Positives = 73/142 (51%), Gaps = 3/142 (2%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V EF+ G++ D L + L P +++A + A+ +AY+ Sbjct: 330 VPLYAVVSE--EPIYIVTEFMTKGSLLDFLK--EGEGKFLKLPQLVDMAAQIADGMAYIE 385 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + IHRD++ NIL+ ++ K+ADFGL+RL + T QG + P Sbjct: 386 RMNYIHRDLRAANILVGDNLVCKIADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 442 Query: 113 CYKLTDKSDVSTSGVVLVELIS 48 + T KSDV + G++L EL++ Sbjct: 443 YGRFTIKSDVWSFGILLTELVT 464
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 60.8 bits (146), Expect = 2e-09 Identities = 43/137 (31%), Positives = 67/137 (48%), Gaps = 4/137 (2%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 ++ EF+ G + D+L C E + L +A + + A+ YL IHRD+ N L Sbjct: 262 IITEFMTYGNLLDYLRECNRQEVNAV--VLLYMATQISSAMEYLEKKNFIHRDLAARNCL 319 Query: 239 LDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLV 60 + + VKVADFGLSRL + + + P K + KSDV GV+L Sbjct: 320 VGENHLVKVADFGLSRLMTGDTYTAHAGTKFPIKWTAPESLAYNKFSIKSDVWAFGVLLW 379 Query: 59 EL----ISSKPGVNMSR 21 E+ +S PG+++S+ Sbjct: 380 EIATYGMSPYPGIDLSQ 396
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 60.8 bits (146), Expect = 2e-09 Identities = 44/138 (31%), Positives = 67/138 (48%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + L+ EF G + HL R A+R + + + A AL+YLH +IHRD+K N Sbjct: 162 IYLILEFAGRGELYQHL---RRAKR-FSEEVASKYIFQMANALSYLHKKHVIHRDIKPEN 217 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 ILL +K++DFG S P ++ T GT Y+ P + + T+K D+ + GV+ Sbjct: 218 ILLGIDGEIKLSDFGWSVHAP---SNRRTTLCGTLDYLPPEMVEGKEHTEKVDLWSLGVL 274 Query: 65 LVELISSKPGVNMSRSHS 12 E + P HS Sbjct: 275 TYEFLVGAPPFEDMSGHS 292
>STK3_HUMAN (Q13188) Serine/threonine-protein kinase 3 (EC 2.7.11.1)| (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1) Length = 491 Score = 60.8 bits (146), Expect = 2e-09 Identities = 44/142 (30%), Positives = 70/142 (49%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V+ Y + + DL +V E+ G+V+D + R + L I T + L YLH Sbjct: 82 VVKYYGSYFKNTDLWIVMEYCGAGSVSDII---RLRNKTLIEDEIATILKSTLKGLEYLH 138 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 + IHRD+K NILL+ H K+ADFG++ + +TV GTP ++ P Q Sbjct: 139 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTV-IGTPFWMAPEVIQEIG 197 Query: 104 LTDKSDVSTSGVVLVELISSKP 39 +D+ + G+ +E+ KP Sbjct: 198 YNCVADIWSLGITSIEMAEGKP 219
>PKN2_CORGL (Q8NU97) Serine/threonine protein kinases pknA (EC 2.7.11.1)| Length = 469 Score = 60.5 bits (145), Expect = 2e-09 Identities = 37/126 (29%), Positives = 68/126 (53%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 +V EF+ ++AD L E L L L++ + A L+ +H ++++HRD+K N+L Sbjct: 100 IVMEFVRGESLADLLE----REGRLPEDLALDVMEQAAHGLSVIHRMDMVHRDIKPGNML 155 Query: 239 LDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLV 60 + + VK+ DFG+++ + + GT YV P Q ++T SD+ + GVV Sbjct: 156 ITANGIVKITDFGIAKAAAAVPLTRTGMVVGTAQYVSPEQAQGKEVTAASDIYSLGVVGY 215 Query: 59 ELISSK 42 E+++ + Sbjct: 216 EMMAGR 221
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 60.5 bits (145), Expect = 2e-09 Identities = 42/132 (31%), Positives = 69/132 (52%), Gaps = 6/132 (4%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE--IIHRDVKTTN 246 LV E++ G++ L A L W LR I ETA + +LH + ++H D+K N Sbjct: 94 LVMEYMETGSLEKLL-----ASEPLPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPAN 148 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQ--GTPGYVDP--VYHQCYKLTDKSDVST 78 ILLD +HVK++DFGL++ L +H ++ GT Y+ P + + K DV + Sbjct: 149 ILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYS 208 Query: 77 SGVVLVELISSK 42 +V+ +++ K Sbjct: 209 FAIVIWGVLTQK 220
>PAK7_MOUSE (Q8C015) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5) Length = 719 Score = 60.5 bits (145), Expect = 2e-09 Identities = 36/130 (27%), Positives = 67/130 (51%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V EF+ G + D + R E + + + +AL+YLH +IHRD+K+ Sbjct: 518 ELWVVMEFLEGGALTDIVTHTRMNEEQIA-----TVCLSVLKALSYLHNQGVIHRDIKSD 572 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 +ILL + +K++DFG EV ++ GTP ++ P + D+ + G+ Sbjct: 573 SILLTSDGRIKLSDFGFCAQVSKEVPKRKSL-VGTPYWMAPEVISRLPYGTEVDIWSLGI 631 Query: 68 VLVELISSKP 39 +++E+I +P Sbjct: 632 MVIEMIDGEP 641
>PKN6_MYXXA (P54738) Serine/threonine-protein kinase pkn6 (EC 2.7.11.1)| Length = 710 Score = 60.5 bits (145), Expect = 2e-09 Identities = 40/117 (34%), Positives = 56/117 (47%), Gaps = 9/117 (7%) Frame = -2 Query: 365 RAAERGLTWPLRLNIAIETAEALAYLH---------PVEIIHRDVKTTNILLDNSFHVKV 213 RAAE L + AE LAY H P+ +IHRDV NIL+ VKV Sbjct: 100 RAAEEALPPAFCAKVVAAAAEGLAYAHEFRDVETGEPLGLIHRDVSPDNILVSRQGAVKV 159 Query: 212 ADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLVELISSK 42 DFG++++ ++ V +G Y+ P Q + + DV GVVL EL++ K Sbjct: 160 VDFGIAKVAGQGHRTLTGVVKGKVAYMPPEQLQAKAMDRRVDVYALGVVLYELLTGK 216
>JAK3_RAT (Q63272) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3)| (JAK-3) Length = 1100 Score = 60.5 bits (145), Expect = 2e-09 Identities = 46/134 (34%), Positives = 73/134 (54%), Gaps = 6/134 (4%) Frame = -2 Query: 431 RDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKT 252 ++L LV E++ +G + D L RA L L A + + + YL +HRD+ Sbjct: 892 QELRLVMEYLPSGCLRDFLQRHRAR---LHNDRLLLFAWQICKGMEYLGARRCVHRDLAA 948 Query: 251 TNILLDNSFHVKVADFGLSRLFPL-EVTHVSTVPQGTPGYVDPVYHQCYKLTD-----KS 90 NIL+++ HVK+ADFGL++L PL + +V VP +P + ++ L+D +S Sbjct: 949 RNILVESEAHVKIADFGLAKLLPLGKDYYVVRVPGQSPIF----WYAPESLSDNIFSRQS 1004 Query: 89 DVSTSGVVLVELIS 48 DV + GVVL EL + Sbjct: 1005 DVWSFGVVLYELFT 1018
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 60.5 bits (145), Expect = 2e-09 Identities = 46/141 (32%), Positives = 69/141 (48%), Gaps = 15/141 (10%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 LV E++ G + L AE ++ I +E E + YLH +IH+D+K NIL Sbjct: 90 LVMEYMEKGNLMHVLK----AEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENIL 145 Query: 239 LDNSFHVKVADFGLSRLFPL-------------EVTHVSTVPQGTPGYVDPVYHQCY--K 105 +DN FH+K+AD GL+ F + EV + GT Y+ P + K Sbjct: 146 VDNDFHIKIADLGLAS-FKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAK 204 Query: 104 LTDKSDVSTSGVVLVELISSK 42 T+KSDV + VVL + ++K Sbjct: 205 PTEKSDVYSFAVVLWAIFANK 225
>KPCD_RAT (P09215) Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta)| Length = 673 Score = 60.1 bits (144), Expect = 3e-09 Identities = 43/134 (32%), Positives = 64/134 (47%), Gaps = 1/134 (0%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNI-AIETAEALAYLHPVEI 273 CT + L V EF+ G + H+ ++G R A E L +LH I Sbjct: 413 CTFQTKDHLFFVMEFLNGGDLMFHIQ-----DKGRFELYRATFYAAEIICGLQFLHGKGI 467 Query: 272 IHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDK 93 I+RD+K N++LD H+K+ADFG+ + ST GTP Y+ P Q K + Sbjct: 468 IYRDLKLDNVMLDKDGHIKIADFGMCKENIFGENRASTF-CGTPDYIAPEILQGLKYSFS 526 Query: 92 SDVSTSGVVLVELI 51 D + GV+L E++ Sbjct: 527 VDWWSFGVLLYEML 540
>KPCD_CANFA (Q5PU49) Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta)| Length = 674 Score = 60.1 bits (144), Expect = 3e-09 Identities = 43/134 (32%), Positives = 64/134 (47%), Gaps = 1/134 (0%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNI-AIETAEALAYLHPVEI 273 CT + L V EF+ G + H+ ++G R A E L +LH I Sbjct: 413 CTFQTKDHLFFVMEFLNGGDLMYHIQ-----DKGRFELYRATFYAAEIVCGLQFLHNKGI 467 Query: 272 IHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDK 93 I+RD+K N++LD H+K+ADFG+ + ST GTP Y+ P Q K + Sbjct: 468 IYRDLKLDNVMLDQDGHIKIADFGMCKENIFGEKQASTF-CGTPDYIAPEILQGLKYSFS 526 Query: 92 SDVSTSGVVLVELI 51 D + GV+L E++ Sbjct: 527 VDWWSFGVLLYEML 540
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 60.1 bits (144), Expect = 3e-09 Identities = 45/140 (32%), Positives = 71/140 (50%), Gaps = 3/140 (2%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V E+++ G++ D L G R L P +++A + A +AY+ Sbjct: 321 VQLYAVVSE--EPIYIVTEYMSKGSLLDFLKG--EMGRYLRLPQLVDMAAQIASGMAYVE 376 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + +HRD++ NIL+ + KVADFGL+RL + T QG + P Sbjct: 377 RMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 433 Query: 113 CYKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 434 YGRFTIKSDVWSFGILLTEL 453
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 60.1 bits (144), Expect = 3e-09 Identities = 46/131 (35%), Positives = 65/131 (49%), Gaps = 3/131 (2%) Frame = -2 Query: 431 RDLLLVYEFIANGTVADHL--HGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDV 258 + L LV E+ + G V D+L HG R E+ R + A+ Y H I+HRD+ Sbjct: 130 KTLYLVMEYASGGEVFDYLVAHG-RMKEKEARAKFR-----QIVSAVQYCHQKYIVHRDL 183 Query: 257 KTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT-DKSDVS 81 K N+LLD ++K+ADFG S F V + G+P Y P Q K + DV Sbjct: 184 KAENLLLDGDMNIKIADFGFSNEF--TVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 241 Query: 80 TSGVVLVELIS 48 + GV+L L+S Sbjct: 242 SLGVILYTLVS 252
>SGK1_RABIT (Q9XT18) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 60.1 bits (144), Expect = 3e-09 Identities = 46/131 (35%), Positives = 65/131 (49%), Gaps = 2/131 (1%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L V ++I G + HL ER P A E A AL YLH + I++RD+K N Sbjct: 172 LYFVLDYINGGELFYHLQ----RERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPEN 227 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDP--VYHQCYKLTDKSDVSTSG 72 ILLD+ H+ + DFGL + +E ++ GTP Y+ P ++ Q Y T D G Sbjct: 228 ILLDSQGHIVLTDFGLCK-ENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRT--VDWWCLG 284 Query: 71 VVLVELISSKP 39 VL E++ P Sbjct: 285 AVLYEMLYGLP 295
>SGK1_MOUSE (Q9WVC6) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 60.1 bits (144), Expect = 3e-09 Identities = 46/131 (35%), Positives = 65/131 (49%), Gaps = 2/131 (1%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L V ++I G + HL ER P A E A AL YLH + I++RD+K N Sbjct: 172 LYFVLDYINGGELFYHLQ----RERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPEN 227 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDP--VYHQCYKLTDKSDVSTSG 72 ILLD+ H+ + DFGL + +E ++ GTP Y+ P ++ Q Y T D G Sbjct: 228 ILLDSQGHIVLTDFGLCK-ENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRT--VDWWCLG 284 Query: 71 VVLVELISSKP 39 VL E++ P Sbjct: 285 AVLYEMLYGLP 295
>NRKB_TRYBB (Q03428) Putative serine/threonine-protein kinase B (EC 2.7.11.1)| Length = 431 Score = 60.1 bits (144), Expect = 3e-09 Identities = 40/130 (30%), Positives = 70/130 (53%), Gaps = 2/130 (1%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAE-RGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 LL+V EF +G + + + + R L + ++ AL Y+H +++HRD+K+ Sbjct: 92 LLIVMEFADSGNLDEQIKPWGTGDARYFQEHEALFLFLQLCLALDYIHSHKMLHRDIKSA 151 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTH-VSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSG 72 N+LL ++ VK+ DFG S + V+ V++ GTP Y+ P + K+DV + G Sbjct: 152 NVLLTSTGLVKLGDFGFSHQYEDTVSGVVASTFCGTPYYLAPELWNNLRYNKKADVWSLG 211 Query: 71 VVLVELISSK 42 V+L E++ K Sbjct: 212 VLLYEIMGMK 221
>M3K2_HUMAN (Q9Y2U5) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 60.1 bits (144), Expect = 3e-09 Identities = 43/143 (30%), Positives = 69/143 (48%), Gaps = 4/143 (2%) Frame = -2 Query: 455 YGCTSRMSRDLLLVY-EFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 YGC L ++ E++ G++ D L A +T I E + YLH Sbjct: 422 YGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQIL----EGVHYLHSN 477 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFP---LEVTHVSTVPQGTPGYVDPVYHQCY 108 I+HRD+K NIL D++ +VK+ DFG S+ L T + +V GTP ++ P Sbjct: 478 MIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSV-TGTPYWMSPEVISGE 536 Query: 107 KLTDKSDVSTSGVVLVELISSKP 39 K+D+ + +VE+++ KP Sbjct: 537 GYGRKADIWSVACTVVEMLTEKP 559
>SGK1_RAT (Q06226) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 430 Score = 60.1 bits (144), Expect = 3e-09 Identities = 46/131 (35%), Positives = 65/131 (49%), Gaps = 2/131 (1%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L V ++I G + HL ER P A E A AL YLH + I++RD+K N Sbjct: 172 LYFVLDYINGGELFYHLQ----RERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPEN 227 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDP--VYHQCYKLTDKSDVSTSG 72 ILLD+ H+ + DFGL + +E ++ GTP Y+ P ++ Q Y T D G Sbjct: 228 ILLDSQGHIVLTDFGLCK-ENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRT--VDWWCLG 284 Query: 71 VVLVELISSKP 39 VL E++ P Sbjct: 285 AVLYEMLYGLP 295
>PAK7_HUMAN (Q9P286) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (PAK-5) Length = 719 Score = 60.1 bits (144), Expect = 3e-09 Identities = 36/130 (27%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V EF+ G + D + R E + + + AL+YLH +IHRD+K+ Sbjct: 518 ELWVVMEFLEGGALTDIVTHTRMNEEQIA-----TVCLSVLRALSYLHNQGVIHRDIKSD 572 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 +ILL + +K++DFG EV ++ GTP ++ P + D+ + G+ Sbjct: 573 SILLTSDGRIKLSDFGFCAQVSKEVPKRKSL-VGTPYWMAPEVISRLPYGTEVDIWSLGI 631 Query: 68 VLVELISSKP 39 +++E+I +P Sbjct: 632 MVIEMIDGEP 641
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 60.1 bits (144), Expect = 3e-09 Identities = 40/139 (28%), Positives = 70/139 (50%), Gaps = 13/139 (9%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + ++ E++ NG++ D L + LT L++A + AE +A++ IHRD++ N Sbjct: 311 IYIITEYMENGSLVDFLKTPSGIK--LTINKLLDMAAQIAEGMAFIEERNYIHRDLRAAN 368 Query: 245 ILLDNSFHVKVADFGLSRL-------------FPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 IL+ ++ K+ADFGL+RL FP++ T + GT Sbjct: 369 ILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGT------------- 415 Query: 104 LTDKSDVSTSGVVLVELIS 48 T KSDV + G++L E+++ Sbjct: 416 FTIKSDVWSFGILLTEIVT 434
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 60.1 bits (144), Expect = 3e-09 Identities = 40/139 (28%), Positives = 70/139 (50%), Gaps = 13/139 (9%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + ++ E++ NG++ D L + LT L++A + AE +A++ IHRD++ N Sbjct: 311 IYIITEYMENGSLVDFLKTPSGIK--LTINKLLDMAAQIAEGMAFIEERNYIHRDLRAAN 368 Query: 245 ILLDNSFHVKVADFGLSRL-------------FPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 IL+ ++ K+ADFGL+RL FP++ T + GT Sbjct: 369 ILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGT------------- 415 Query: 104 LTDKSDVSTSGVVLVELIS 48 T KSDV + G++L E+++ Sbjct: 416 FTIKSDVWSFGILLTEIVT 434
>NEK2_MOUSE (O35942) Serine/threonine-protein kinase Nek2 (EC 2.7.11.1)| (NimA-related protein kinase 2) Length = 443 Score = 60.1 bits (144), Expect = 3e-09 Identities = 39/139 (28%), Positives = 64/139 (46%), Gaps = 5/139 (3%) Frame = -2 Query: 440 RMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE----- 276 R + L +V E+ G +A + + L L + + AL H Sbjct: 77 RTNTTLYIVMEYCEGGDLASVISKGTKDRQYLEEEFVLRVMTQLTLALKECHRRSDGGHT 136 Query: 275 IIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD 96 ++HRD+K N+ LD+ +VK+ DFGL+R+ + + T GTP Y+ P C + Sbjct: 137 VLHRDLKPANVFLDSKHNVKLGDFGLARILNHDTSFAKTF-VGTPYYMSPEQMSCLSYNE 195 Query: 95 KSDVSTSGVVLVELISSKP 39 KSD+ + +L EL + P Sbjct: 196 KSDIWSLACLLYELCALMP 214
>KPCD_MOUSE (P28867) Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta)| Length = 674 Score = 59.7 bits (143), Expect = 4e-09 Identities = 43/134 (32%), Positives = 64/134 (47%), Gaps = 1/134 (0%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNI-AIETAEALAYLHPVEI 273 CT + L V EF+ G + H+ ++G R A E L +LH I Sbjct: 413 CTFQTKDHLFFVMEFLNGGDLMFHIQ-----DKGRFELYRATFYAAEIICGLQFLHSKGI 467 Query: 272 IHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDK 93 I+RD+K N++LD H+K+ADFG+ + ST GTP Y+ P Q K + Sbjct: 468 IYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTF-CGTPDYIAPEILQGLKYSFS 526 Query: 92 SDVSTSGVVLVELI 51 D + GV+L E++ Sbjct: 527 VDWWSFGVLLYEML 540
>KPCE_RABIT (P10830) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 736 Score = 59.7 bits (143), Expect = 4e-09 Identities = 44/140 (31%), Positives = 65/140 (46%) Frame = -2 Query: 458 LYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 LY C R L V E++ G + + R + P A E AL +LH Sbjct: 471 LYCCFQTKDR-LFFVMEYVNGGDLMFQIQRSRKFDE----PRSRFYAAEVTSALMFLHQH 525 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT 99 +I+RD+K NILLD H K+ADFG+ + L +T GTP Y+ P Q + Sbjct: 526 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTF-CGTPDYIAPEILQELEYG 584 Query: 98 DKSDVSTSGVVLVELISSKP 39 D GV++ E+++ +P Sbjct: 585 PSVDWWALGVLMYEMMAGQP 604
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 59.7 bits (143), Expect = 4e-09 Identities = 33/95 (34%), Positives = 54/95 (56%) Frame = -2 Query: 323 IAIETAEALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGT 144 I ET + L +LH IIHRD+K+ N+LLD +VK+ DFG + +T+ GT Sbjct: 783 ICFETLKGLQHLHKKHIIHRDIKSDNVLLDAYGNVKITDFGFCAKLTDQRNKRATM-VGT 841 Query: 143 PGYVDPVYHQCYKLTDKSDVSTSGVVLVELISSKP 39 P ++ P + + +K DV + G++ +E+I +P Sbjct: 842 PYWMAPEVVKQKEYDEKVDVWSLGIMTIEMIEGEP 876
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 59.7 bits (143), Expect = 4e-09 Identities = 33/103 (32%), Positives = 58/103 (56%), Gaps = 2/103 (1%) Frame = -2 Query: 317 IETAEALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLF--PLEVTHVSTVPQGT 144 ++ EALAY+H ++HRD+K +NI++D+ V++ DFGL++ +T + GT Sbjct: 226 LQICEALAYIHGHGLVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAAITEAGKL-VGT 284 Query: 143 PGYVDPVYHQCYKLTDKSDVSTSGVVLVELISSKPGVNMSRSH 15 Y+ P L ++D+ + GV+L EL+S +P + H Sbjct: 285 YRYMAPEQILGEPLDGRADLYSLGVILYELLSGRPPFDAKTPH 327
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 59.7 bits (143), Expect = 4e-09 Identities = 34/102 (33%), Positives = 54/102 (52%) Frame = -2 Query: 353 RGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEV 174 R L P L A + AE ++YL ++HRD+ N+L+D+ KVADFGL+RL ++ Sbjct: 320 RALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDI 379 Query: 173 THVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLVELIS 48 S+ + + P + KSDV + GV+L E+ + Sbjct: 380 YSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFT 421
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 59.7 bits (143), Expect = 4e-09 Identities = 40/129 (31%), Positives = 66/129 (51%), Gaps = 2/129 (1%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 +V E++ T+ D +H + + + I + +AL + H IIHRDVK NI+ Sbjct: 90 IVMEYVDGATLRDIVH----TDGPMPPQQAIEIVADACQALNFSHQNGIIHRDVKPANIM 145 Query: 239 LDNSFHVKVADFGLSRLF--PLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 + + VKV DFG++R VT + V GT Y+ P + + +SDV + G V Sbjct: 146 ISATNAVKVMDFGIARAIADSTSVTQTAAV-IGTAQYLSPEQARGDSVDARSDVYSLGCV 204 Query: 65 LVELISSKP 39 L E+++ +P Sbjct: 205 LYEILTGEP 213
>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8) Length = 979 Score = 59.7 bits (143), Expect = 4e-09 Identities = 38/128 (29%), Positives = 65/128 (50%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 LL+ E+ G + D + R ++ + + + A++ +H I+HRD+KT N Sbjct: 124 LLIELEYCNGGNLYDKI--LRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLN 181 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 I L + +K+ D+GL++ E + T+ GTP Y+ P Q K KSD+ G V Sbjct: 182 IFLTKANLIKLGDYGLAKKLNSEYSMAETL-VGTPYYMSPELCQGVKYNFKSDIWAVGCV 240 Query: 65 LVELISSK 42 + EL++ K Sbjct: 241 IFELLTLK 248
>KPCE_HUMAN (Q02156) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 59.7 bits (143), Expect = 4e-09 Identities = 44/140 (31%), Positives = 65/140 (46%) Frame = -2 Query: 458 LYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 LY C R L V E++ G + + R + P A E AL +LH Sbjct: 472 LYCCFQTKDR-LFFVMEYVNGGDLMFQIQRSRKFDE----PRSRFYAAEVTSALMFLHQH 526 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT 99 +I+RD+K NILLD H K+ADFG+ + L +T GTP Y+ P Q + Sbjct: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTF-CGTPDYIAPEILQELEYG 585 Query: 98 DKSDVSTSGVVLVELISSKP 39 D GV++ E+++ +P Sbjct: 586 PSVDWWALGVLMYEMMAGQP 605
>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) Length = 984 Score = 59.7 bits (143), Expect = 4e-09 Identities = 38/128 (29%), Positives = 65/128 (50%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 LL+ E+ G + D + R ++ + + + A++ +H I+HRD+KT N Sbjct: 124 LLIELEYCNGGNLYDKI--LRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLN 181 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 I L + +K+ D+GL++ E + T+ GTP Y+ P Q K KSD+ G V Sbjct: 182 IFLTKANLIKLGDYGLAKKLNSEYSMAETL-VGTPYYMSPELCQGVKYNFKSDIWAVGCV 240 Query: 65 LVELISSK 42 + EL++ K Sbjct: 241 IFELLTLK 248
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 59.7 bits (143), Expect = 4e-09 Identities = 41/130 (31%), Positives = 67/130 (51%), Gaps = 3/130 (2%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 +V E++ T+ D +H E +T + + + +AL + H IIHRDVK NI+ Sbjct: 90 IVMEYVDGVTLRDIVH----TEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIM 145 Query: 239 LDNSFHVKVADFGLSRLFP---LEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 + + VKV DFG++R VT + V GT Y+ P + + +SDV + G Sbjct: 146 ISATNAVKVMDFGIARAIADSGNSVTQTAAV-IGTAQYLSPEQARGDSVDARSDVYSLGC 204 Query: 68 VLVELISSKP 39 VL E+++ +P Sbjct: 205 VLYEVLTGEP 214
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 59.7 bits (143), Expect = 4e-09 Identities = 41/130 (31%), Positives = 67/130 (51%), Gaps = 3/130 (2%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 +V E++ T+ D +H E +T + + + +AL + H IIHRDVK NI+ Sbjct: 90 IVMEYVDGVTLRDIVH----TEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIM 145 Query: 239 LDNSFHVKVADFGLSRLFP---LEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 + + VKV DFG++R VT + V GT Y+ P + + +SDV + G Sbjct: 146 ISATNAVKVMDFGIARAIADSGNSVTQTAAV-IGTAQYLSPEQARGDSVDARSDVYSLGC 204 Query: 68 VLVELISSKP 39 VL E+++ +P Sbjct: 205 VLYEVLTGEP 214
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 59.7 bits (143), Expect = 4e-09 Identities = 37/130 (28%), Positives = 64/130 (49%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 DL ++ E++ G++ D + C E + R ET L +LH ++HRD+K+ Sbjct: 689 DLWVIMEYMEGGSLTDVVTHCILTEGQIGAVCR-----ETLSGLEFLHSKGVLHRDIKSD 743 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 NILL +K+ DFG E+ T GTP ++ P + K D+ + G+ Sbjct: 744 NILLSMEGDIKLTDFGFCAQIN-ELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGI 802 Query: 68 VLVELISSKP 39 +++E+I +P Sbjct: 803 MIIEMIEGEP 812
>TNIK_MOUSE (P83510) Traf2 and NCK-interacting kinase (EC 2.7.11.1) (Fragments)| Length = 916 Score = 59.3 bits (142), Expect = 5e-09 Identities = 43/138 (31%), Positives = 64/138 (46%), Gaps = 5/138 (3%) Frame = -2 Query: 437 MSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDV 258 M L LV EF G+V D + + W I E L++LH ++IHRD+ Sbjct: 97 MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY--ICREILRGLSHLHQHKVIHRDI 154 Query: 257 KTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD-----K 93 K N+LL + VK+ DFG+S V +T GTP ++ P C + D K Sbjct: 155 KGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTF-IGTPYWMAPEVIACDENPDATYDFK 213 Query: 92 SDVSTSGVVLVELISSKP 39 SD+ + G+ +E+ P Sbjct: 214 SDLWSLGITAIEMAEGAP 231
>JAK3_HUMAN (P52333) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3)| (JAK-3) (Leukocyte janus kinase) (L-JAK) Length = 1124 Score = 59.3 bits (142), Expect = 5e-09 Identities = 43/133 (32%), Positives = 68/133 (51%), Gaps = 5/133 (3%) Frame = -2 Query: 431 RDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKT 252 + L LV E++ +G + D L RA L L + + + + YL +HRD+ Sbjct: 896 QSLRLVMEYLPSGCLRDFLQRHRAR---LDASRLLLYSSQICKGMEYLGSRRCVHRDLAA 952 Query: 251 TNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD-----KSD 87 NIL+++ HVK+ADFGL++L PL+ + PG ++ L+D +SD Sbjct: 953 RNILVESEAHVKIADFGLAKLLPLDKDYYVV---REPGQSPIFWYAPESLSDNIFSRQSD 1009 Query: 86 VSTSGVVLVELIS 48 V + GVVL EL + Sbjct: 1010 VWSFGVVLYELFT 1022
>TNIK_HUMAN (Q9UKE5) TRAF2 and NCK-interacting kinase (EC 2.7.11.1)| Length = 1360 Score = 59.3 bits (142), Expect = 5e-09 Identities = 43/138 (31%), Positives = 64/138 (46%), Gaps = 5/138 (3%) Frame = -2 Query: 437 MSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDV 258 M L LV EF G+V D + + W I E L++LH ++IHRD+ Sbjct: 97 MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY--ICREILRGLSHLHQHKVIHRDI 154 Query: 257 KTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD-----K 93 K N+LL + VK+ DFG+S V +T GTP ++ P C + D K Sbjct: 155 KGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTF-IGTPYWMAPEVIACDENPDATYDFK 213 Query: 92 SDVSTSGVVLVELISSKP 39 SD+ + G+ +E+ P Sbjct: 214 SDLWSLGITAIEMAEGAP 231
>NRKA_TRYBB (Q08942) Putative serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 431 Score = 59.3 bits (142), Expect = 5e-09 Identities = 43/131 (32%), Positives = 71/131 (54%), Gaps = 3/131 (2%) Frame = -2 Query: 425 LLLVYEFIANGTVADH--LHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKT 252 LL+V EF +G + + L G A R L + ++ AL Y+H +++HRD+K+ Sbjct: 92 LLIVMEFADSGNLDEQIKLRGSGDA-RYFQEHEALFLFLQLCLALDYIHSHKMLHRDIKS 150 Query: 251 TNILLDNSFHVKVADFGLSRLFPLEVTH-VSTVPQGTPGYVDPVYHQCYKLTDKSDVSTS 75 N+LL ++ VK+ DFG S + V+ V++ GTP Y+ P + K+DV + Sbjct: 151 ANVLLTSTGLVKLGDFGFSHQYEDTVSGVVASTFCGTPYYLAPELWNNKRYNKKADVWSL 210 Query: 74 GVVLVELISSK 42 GV+L E++ K Sbjct: 211 GVLLYEIMGMK 221
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 59.3 bits (142), Expect = 5e-09 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 5/142 (3%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERG--LTWPLRLNIAIETAEALAY 291 V LY S + +V E+++ G++ D L G E G L P +++A + A +AY Sbjct: 322 VQLYAVVSE--EPIYIVIEYMSKGSLLDFLKG----EMGKYLRLPQLVDMAAQIASGMAY 375 Query: 290 LHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVY 120 + + +HRD++ NIL+ + KVADFGL+RL + T QG + P Sbjct: 376 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTAPEA 432 Query: 119 HQCYKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 433 ALYGRFTIKSDVWSFGILLTEL 454
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 59.3 bits (142), Expect = 5e-09 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 5/142 (3%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERG--LTWPLRLNIAIETAEALAY 291 V LY S + +V E+++ G++ D L G E G L P +++A + A +AY Sbjct: 322 VQLYAVVSE--EPIYIVIEYMSKGSLLDFLKG----EMGKYLRLPQLVDMAAQIASGMAY 375 Query: 290 LHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVY 120 + + +HRD++ NIL+ + KVADFGL+RL + T QG + P Sbjct: 376 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTAPEA 432 Query: 119 HQCYKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 433 ALYGRFTIKSDVWSFGILLTEL 454
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 59.3 bits (142), Expect = 5e-09 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 5/142 (3%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERG--LTWPLRLNIAIETAEALAY 291 V LY S + +V E+++ G++ D L G E G L P +++A + A +AY Sbjct: 322 VQLYAVVSE--EPIYIVIEYMSKGSLLDFLKG----EMGKYLRLPQLVDMAAQIASGMAY 375 Query: 290 LHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVY 120 + + +HRD++ NIL+ + KVADFGL+RL + T QG + P Sbjct: 376 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTAPEA 432 Query: 119 HQCYKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 433 ALYGRFTIKSDVWSFGILLTEL 454
>KIN15_CAEEL (P34891) Receptor-like tyrosine-protein kinase kin-15 precursor (EC| 2.7.10.1) Length = 488 Score = 59.3 bits (142), Expect = 5e-09 Identities = 37/109 (33%), Positives = 62/109 (56%), Gaps = 5/109 (4%) Frame = -2 Query: 329 LNIAIETAEALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQ 150 L+ + + AE + YL + +HRD+ N+LL+ + +++ADFGL+R + ++ + T Sbjct: 297 LSFSYQIAEGMEYLASIPCVHRDLALRNVLLNKNKTIRIADFGLARKYQVDGYYRITKGV 356 Query: 149 GTP---GYVDPVYHQCYKLTDKSDVSTSGVVLVELIS--SKPGVNMSRS 18 GTP ++ P + K T+KSDV + GV L E+ S P N+S S Sbjct: 357 GTPMPARWMAPEVMREGKCTEKSDVWSYGVSLYEMFSLGELPYSNVSNS 405
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 59.3 bits (142), Expect = 5e-09 Identities = 44/141 (31%), Positives = 69/141 (48%), Gaps = 7/141 (4%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHL--HGCRAAERGLTWPLRLNIAIETAEALAYLHPVE 276 C S R+L L+ E++ G++ D+L H R + L L + + + YL Sbjct: 917 CYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKL-----LQYTSQICKGMEYLGTKR 971 Query: 275 IIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD 96 IHRD+ T NIL++N VK+ DFGL+++ P + + PG ++ LT+ Sbjct: 972 YIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKV---KEPGESPIFWYAPQSLTE 1028 Query: 95 K-----SDVSTSGVVLVELIS 48 SDV + GVVL EL + Sbjct: 1029 SKFSVASDVWSFGVVLYELFT 1049 Score = 29.6 bits (65), Expect = 4.0 Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 8/84 (9%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNI 243 +LV EF+ G++ +L + + + +L +A + A A+ +L +IH +V NI Sbjct: 623 ILVQEFVKFGSLDTYL---KKNKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNI 679 Query: 242 LL--------DNSFHVKVADFGLS 195 LL N +K++D G+S Sbjct: 680 LLIREEDRRTGNPPFIKLSDPGIS 703
>RK_HUMAN (Q15835) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 563 Score = 59.3 bits (142), Expect = 5e-09 Identities = 38/129 (29%), Positives = 63/129 (48%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 DL LV + G + H++ G P L + L +LH I++RD+K Sbjct: 262 DLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPE 321 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 N+LLDN +V+++D GL+ + L+ + GTPG++ P Q + D GV Sbjct: 322 NVLLDNDGNVRISDLGLA-VELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSVDYFALGV 380 Query: 68 VLVELISSK 42 L E+I+++ Sbjct: 381 TLYEMIAAR 389
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 59.3 bits (142), Expect = 5e-09 Identities = 43/141 (30%), Positives = 69/141 (48%), Gaps = 9/141 (6%) Frame = -2 Query: 437 MSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDV 258 M+ + LV E+ G +AD+LH R +RL + + A A+ LH IIHRD+ Sbjct: 84 MANSVYLVMEYCNGGDLADYLHTMRTLSEDT---VRLFLQ-QIAGAMRLLHSKGIIHRDL 139 Query: 257 KTTNILLDN---------SFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 K NILL N + VK+ADFG +R L+ ++ G+P Y+ P Sbjct: 140 KPQNILLSNPGGRRANPSNIRVKIADFGFARY--LQSNMMAATLCGSPMYMAPEVIMSQH 197 Query: 104 LTDKSDVSTSGVVLVELISSK 42 K+D+ + G ++ + ++ K Sbjct: 198 YDGKADLWSIGTIVYQCLTGK 218
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 59.3 bits (142), Expect = 5e-09 Identities = 43/137 (31%), Positives = 68/137 (49%), Gaps = 4/137 (2%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 +V E++ G + D+L C E +T + L +A + + A+ YL IHRD+ N L Sbjct: 359 IVTEYMPYGNLLDYLRECNREE--VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 416 Query: 239 LDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLV 60 + + VKVADFGLSRL + + + P + KSDV GV+L Sbjct: 417 VGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLW 476 Query: 59 EL----ISSKPGVNMSR 21 E+ +S PG+++S+ Sbjct: 477 EIATYGMSPYPGIDLSQ 493
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 59.3 bits (142), Expect = 5e-09 Identities = 44/140 (31%), Positives = 71/140 (50%), Gaps = 3/140 (2%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V E+++ G++ D L G + L P +++A + A +AY+ Sbjct: 325 VQLYAVVSE--EPIYIVTEYMSKGSLLDFLKG--ETGKYLRLPQLVDMAAQIASGMAYVE 380 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + +HRD++ NIL+ + KVADFGL+RL + T QG + P Sbjct: 381 RMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 437 Query: 113 CYKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 438 YGRFTIKSDVWSFGILLTEL 457
>MARK3_MOUSE (Q03141) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (MPK-10) (ELKL motif kinase 2) Length = 753 Score = 59.3 bits (142), Expect = 5e-09 Identities = 45/131 (34%), Positives = 67/131 (51%), Gaps = 3/131 (2%) Frame = -2 Query: 431 RDLLLVYEFIANGTVADHL--HGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDV 258 + L L+ E+ + G V D+L HG R E+ R + A+ Y H I+HRD+ Sbjct: 126 KTLYLIMEYASGGEVFDYLVAHG-RMKEKEARAKFR-----QIVSAVQYCHQKRIVHRDL 179 Query: 257 KTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT-DKSDVS 81 K N+LLD ++K+ADFG S F + + + T G+P Y P Q K + DV Sbjct: 180 KAENLLLDADMNIKIADFGFSNEFTVG-SKLDTF-CGSPPYAAPELFQGKKYDGPEVDVW 237 Query: 80 TSGVVLVELIS 48 + GV+L L+S Sbjct: 238 SLGVILYTLVS 248
>KPCA_RAT (P05696) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 59.3 bits (142), Expect = 5e-09 Identities = 40/140 (28%), Positives = 67/140 (47%) Frame = -2 Query: 458 LYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 L+ C + R L V E++ G + H+ + P + A E + L +LH Sbjct: 402 LHSCFQTVDR-LYFVMEYVNGGDLMYHIQQVGKFKE----PQAVFYAAEISIGLFFLHKR 456 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT 99 II+RD+K N++LD+ H+K+ADFG+ + ++ T GTP Y+ P Sbjct: 457 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTF-CGTPDYIAPEIIAYQPYG 515 Query: 98 DKSDVSTSGVVLVELISSKP 39 D GV+L E+++ +P Sbjct: 516 KSVDWWAYGVLLYEMLAGQP 535
>KPCA_RABIT (P10102) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 59.3 bits (142), Expect = 5e-09 Identities = 40/140 (28%), Positives = 67/140 (47%) Frame = -2 Query: 458 LYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 L+ C + R L V E++ G + H+ + P + A E + L +LH Sbjct: 402 LHSCFQTVDR-LYFVMEYVNGGDLMYHIQQVGKFKE----PQAVFYAAEISIGLFFLHKR 456 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT 99 II+RD+K N++LD+ H+K+ADFG+ + ++ T GTP Y+ P Sbjct: 457 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTF-CGTPDYIAPEIIAYQPYG 515 Query: 98 DKSDVSTSGVVLVELISSKP 39 D GV+L E+++ +P Sbjct: 516 KSVDWWAYGVLLYEMLAGQP 535
>KPCA_HUMAN (P17252) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 59.3 bits (142), Expect = 5e-09 Identities = 40/140 (28%), Positives = 67/140 (47%) Frame = -2 Query: 458 LYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 L+ C + R L V E++ G + H+ + P + A E + L +LH Sbjct: 402 LHSCFQTVDR-LYFVMEYVNGGDLMYHIQQVGKFKE----PQAVFYAAEISIGLFFLHKR 456 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT 99 II+RD+K N++LD+ H+K+ADFG+ + ++ T GTP Y+ P Sbjct: 457 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTF-CGTPDYIAPEIIAYQPYG 515 Query: 98 DKSDVSTSGVVLVELISSKP 39 D GV+L E+++ +P Sbjct: 516 KSVDWWAYGVLLYEMLAGQP 535
>KPCA_BOVIN (P04409) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 59.3 bits (142), Expect = 5e-09 Identities = 40/140 (28%), Positives = 67/140 (47%) Frame = -2 Query: 458 LYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 L+ C + R L V E++ G + H+ + P + A E + L +LH Sbjct: 402 LHSCFQTVDR-LYFVMEYVNGGDLMYHIQQVGKFKE----PQAVFYAAEISIGLFFLHKR 456 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT 99 II+RD+K N++LD+ H+K+ADFG+ + ++ T GTP Y+ P Sbjct: 457 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTF-CGTPDYIAPEIIAYQPYG 515 Query: 98 DKSDVSTSGVVLVELISSKP 39 D GV+L E+++ +P Sbjct: 516 KSVDWWAYGVLLYEMLAGQP 535
>SLK_RAT (O08815) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1206 Score = 58.9 bits (141), Expect = 6e-09 Identities = 48/147 (32%), Positives = 70/147 (47%), Gaps = 5/147 (3%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L ++ EF A G V + ER LT + +T EAL YLH +IIHRD+K Sbjct: 103 NLWILIEFCAGGAVDAVM---LELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAG 159 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD-----KSDV 84 NIL +K+ADFG+S + + GTP ++ P C D K+DV Sbjct: 160 NILFTLDGDIKLADFGVSAKNTRTIQRRDSF-IGTPYWMAPEVVMCETSKDRPYDYKADV 218 Query: 83 STSGVVLVELISSKPGVNMSRSHSEIN 3 + G+ L+E+ +P H E+N Sbjct: 219 WSLGITLIEMAEIEP------PHHELN 239
>SLK_MOUSE (O54988) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4) Length = 1233 Score = 58.9 bits (141), Expect = 6e-09 Identities = 48/147 (32%), Positives = 70/147 (47%), Gaps = 5/147 (3%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L ++ EF A G V + ER LT + +T EAL YLH +IIHRD+K Sbjct: 103 NLWILIEFCAGGAVDAVM---LELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAG 159 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD-----KSDV 84 NIL +K+ADFG+S + + GTP ++ P C D K+DV Sbjct: 160 NILFTLDGDIKLADFGVSAKNTRTIQRRDSF-IGTPYWMAPEVVMCETSKDRPYDYKADV 218 Query: 83 STSGVVLVELISSKPGVNMSRSHSEIN 3 + G+ L+E+ +P H E+N Sbjct: 219 WSLGITLIEMAEIEP------PHHELN 239
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 58.9 bits (141), Expect = 6e-09 Identities = 41/138 (29%), Positives = 68/138 (49%), Gaps = 13/138 (9%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L + E+I GT+ + ++ + W R++ A + A +AYLH + IIHRD+ + N Sbjct: 416 LNFITEYIKGGTLRGLI---KSMDSHYPWSQRVSFAKDIAAGMAYLHSMNIIHRDLNSHN 472 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVT---HVSTVPQ----------GTPGYVDPVYHQCYK 105 L+ + V VADFGL+RL E H+ + + G P ++ P Sbjct: 473 CLVRENKSVVVADFGLARLMVDEKNQPEHLQNLKKPDRKKRYTVVGNPYWMAPEMINGRS 532 Query: 104 LTDKSDVSTSGVVLVELI 51 +K D+ + G+VL E+I Sbjct: 533 YDEKVDIFSFGIVLCEII 550
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 58.9 bits (141), Expect = 6e-09 Identities = 43/142 (30%), Positives = 73/142 (51%), Gaps = 3/142 (2%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V E++ G++ D L + L P +++A + A+ +AY+ Sbjct: 326 VPLYAVVSE--EPIYIVTEYMIKGSLLDFLK--EGNGKYLKLPQLVDMAAQIADGMAYIE 381 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + IHRD++ NIL+ ++ K+ADFGL+RL + T QG + P Sbjct: 382 RMNYIHRDLRAANILVGDNLVCKIADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 438 Query: 113 CYKLTDKSDVSTSGVVLVELIS 48 + T KSDV + G++L EL++ Sbjct: 439 YGRFTIKSDVWSFGILLTELVA 460
>PAK2_RAT (Q64303) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p62-PAK) Length = 524 Score = 58.9 bits (141), Expect = 6e-09 Identities = 38/130 (29%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++A G++ D + E + R E +AL +LH ++IHRD+K+ Sbjct: 318 ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCR-----ECLQALEFLHANQVIHRDIKSD 372 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 N+LL VK+ DFG E + ST+ GTP ++ P K D+ + G+ Sbjct: 373 NVLLGMEGSVKLTDFGFCAQITPEQSKRSTM-VGTPYWMAPEVVTRKAYGPKVDIWSLGI 431 Query: 68 VLVELISSKP 39 + +E++ +P Sbjct: 432 MAIEMVEGEP 441
>PAK2_RABIT (Q29502) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p21-activated protein kinase I) (PAKI) Length = 524 Score = 58.9 bits (141), Expect = 6e-09 Identities = 38/130 (29%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++A G++ D + E + R E +AL +LH ++IHRD+K+ Sbjct: 318 ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCR-----ECLQALEFLHANQVIHRDIKSD 372 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 N+LL VK+ DFG E + ST+ GTP ++ P K D+ + G+ Sbjct: 373 NVLLGMEGSVKLTDFGFCAQITPEQSKRSTM-VGTPYWMAPEVVTRKAYGPKVDIWSLGI 431 Query: 68 VLVELISSKP 39 + +E++ +P Sbjct: 432 MAIEMVEGEP 441
>PAK2_MOUSE (Q8CIN4) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) Length = 524 Score = 58.9 bits (141), Expect = 6e-09 Identities = 38/130 (29%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++A G++ D + E + R E +AL +LH ++IHRD+K+ Sbjct: 318 ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCR-----ECLQALEFLHANQVIHRDIKSD 372 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 N+LL VK+ DFG E + ST+ GTP ++ P K D+ + G+ Sbjct: 373 NVLLGMEGSVKLTDFGFCAQITPEQSKRSTM-VGTPYWMAPEVVTRKAYGPKVDIWSLGI 431 Query: 68 VLVELISSKP 39 + +E++ +P Sbjct: 432 MAIEMVEGEP 441
>PAK2_HUMAN (Q13177) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 58.9 bits (141), Expect = 6e-09 Identities = 38/130 (29%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++A G++ D + E + R E +AL +LH ++IHRD+K+ Sbjct: 318 ELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCR-----ECLQALEFLHANQVIHRDIKSD 372 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 N+LL VK+ DFG E + ST+ GTP ++ P K D+ + G+ Sbjct: 373 NVLLGMEGSVKLTDFGFCAQITPEQSKRSTM-VGTPYWMAPEVVTRKAYGPKVDIWSLGI 431 Query: 68 VLVELISSKP 39 + +E++ +P Sbjct: 432 MAIEMVEGEP 441
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 58.9 bits (141), Expect = 6e-09 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 5/142 (3%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERG--LTWPLRLNIAIETAEALAY 291 V LY S + +V E+++ G++ D L G E G L P +++A + A +AY Sbjct: 322 VQLYAVVSE--EPIYIVTEYMSKGSLLDFLKG----EMGKYLRLPQLVDMAAQIASGMAY 375 Query: 290 LHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVY 120 + + +HRD++ NIL+ + KVADFGL+RL + T QG + P Sbjct: 376 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTAPEA 432 Query: 119 HQCYKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 433 ALYGRFTIKSDVWSFGILLTEL 454
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 58.9 bits (141), Expect = 6e-09 Identities = 40/152 (26%), Positives = 78/152 (51%), Gaps = 4/152 (2%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEII 270 C+ R + +V E+++ G++ D+L + L P +++A + A +A+L I Sbjct: 302 CSDR--EPIYIVTEYMSGGSLLDYLS--KGEGVNLQLPTLIDMAAQVASGMAFLEAQGYI 357 Query: 269 HRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKS 90 HRD+ NIL+ ++ KVADFGL+RL + + + P + T KS Sbjct: 358 HRDLAARNILVGENYICKVADFGLARLIEDDEYTAHEGAKFPIKWTAPEAALYNRFTIKS 417 Query: 89 DVSTSGVVLVELISS----KPGVNMSRSHSEI 6 DV + G+++ E+++ PG+ +++ +E+ Sbjct: 418 DVWSFGILMAEIVTKGRIPYPGMTNAQTIAEV 449
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 58.9 bits (141), Expect = 6e-09 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 5/142 (3%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERG--LTWPLRLNIAIETAEALAY 291 V LY S + +V E+++ G++ D L G E G L P +++A + A +AY Sbjct: 322 VQLYAVVSE--EPIYIVTEYMSKGSLLDFLKG----EMGKYLRLPQLVDMAAQIASGMAY 375 Query: 290 LHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVY 120 + + +HRD++ NIL+ + KVADFGL+RL + T QG + P Sbjct: 376 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTAPEA 432 Query: 119 HQCYKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 433 ALYGRFTIKSDVWSFGILLTEL 454
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 58.9 bits (141), Expect = 6e-09 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 5/142 (3%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERG--LTWPLRLNIAIETAEALAY 291 V LY S + +V E+++ G++ D L G E G L P +++A + A +AY Sbjct: 322 VRLYAVVSE--EPIYIVTEYMSKGSLLDFLKG----EMGKYLRLPQLVDMAAQIASGMAY 375 Query: 290 LHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVY 120 + + +HRD++ NIL+ + KVADFGL+RL + T QG + P Sbjct: 376 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTAPEA 432 Query: 119 HQCYKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 433 ALYGRFTIKSDVWSFGILLTEL 454
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 58.9 bits (141), Expect = 6e-09 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 5/142 (3%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERG--LTWPLRLNIAIETAEALAY 291 V LY S + +V E+++ G++ D L G E G L P +++A + A +AY Sbjct: 322 VQLYAVVSE--EPIYIVTEYMSKGSLLDFLKG----EMGKYLRLPQLVDMAAQIASGMAY 375 Query: 290 LHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVY 120 + + +HRD++ NIL+ + KVADFGL+RL + T QG + P Sbjct: 376 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTAPEA 432 Query: 119 HQCYKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 433 ALYGRFTIKSDVWSFGILLTEL 454
>PKN1_COREF (Q8FUI5) Probable serine/threonine protein kinase CE0033 (EC| 2.7.11.1) Length = 660 Score = 58.9 bits (141), Expect = 6e-09 Identities = 35/97 (36%), Positives = 51/97 (52%), Gaps = 2/97 (2%) Frame = -2 Query: 323 IAIETAEALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQ-- 150 I I AL H IIHRDVK NI+++N+ VKV DFG++R + ++ Sbjct: 116 IMIPVCHALQSSHEAGIIHRDVKPANIMINNTGGVKVMDFGIARALDDSTSAMTQTAAVI 175 Query: 149 GTPGYVDPVYHQCYKLTDKSDVSTSGVVLVELISSKP 39 GT Y+ P + +SDV +G VL EL++ +P Sbjct: 176 GTAQYLSPEQARGKPADARSDVYAAGCVLYELVTGRP 212
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 58.9 bits (141), Expect = 6e-09 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 5/142 (3%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERG--LTWPLRLNIAIETAEALAY 291 V LY S + +V E+++ G++ D L G E G L P +++A + A +AY Sbjct: 322 VQLYAVVSE--EPIYIVTEYMSKGSLLDFLKG----EMGKYLRLPQLVDMAAQIASGMAY 375 Query: 290 LHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVY 120 + + +HRD++ NIL+ + KVADFGL+RL + T QG + P Sbjct: 376 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTAPEA 432 Query: 119 HQCYKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 433 ALYGRFTIKSDVWSFGILLTEL 454
>SLK_CAVPO (O55092) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1231 Score = 58.9 bits (141), Expect = 6e-09 Identities = 48/147 (32%), Positives = 70/147 (47%), Gaps = 5/147 (3%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L ++ EF A G V + ER LT + +T EAL YLH +IIHRD+K Sbjct: 103 NLWILIEFCAGGAVDAVM---LELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAG 159 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD-----KSDV 84 NIL +K+ADFG+S + + GTP ++ P C D K+DV Sbjct: 160 NILFTLDGDIKLADFGVSAKNTRTIQRRDSF-IGTPYWMAPEVVMCETSKDRPYDYKADV 218 Query: 83 STSGVVLVELISSKPGVNMSRSHSEIN 3 + G+ L+E+ +P H E+N Sbjct: 219 WSLGITLIEMAEIEP------PHHELN 239
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 58.9 bits (141), Expect = 6e-09 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 5/142 (3%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERG--LTWPLRLNIAIETAEALAY 291 V LY S + +V E+++ G++ D L G E G L P +++A + A +AY Sbjct: 322 VQLYAVVSE--EPIYIVTEYMSKGSLLDFLKG----EMGKYLRLPQLVDMAAQIASGMAY 375 Query: 290 LHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVY 120 + + +HRD++ NIL+ + KVADFGL+RL + T QG + P Sbjct: 376 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTAPEA 432 Query: 119 HQCYKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 433 ALYGRFTIKSDVWSFGILLTEL 454
>PAK4_MOUSE (Q8BTW9) Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1)| (p21-activated kinase 4) (PAK-4) Length = 593 Score = 58.9 bits (141), Expect = 6e-09 Identities = 37/130 (28%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V EF+ G + D + R E + + + +ALA LH +IHRD+K+ Sbjct: 392 ELWVVMEFLEGGALTDIVTHTRMNEEQIA-----AVCLAVLQALAVLHAQGVIHRDIKSD 446 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 +ILL + VK++DFG EV ++ GTP ++ P + D+ + GV Sbjct: 447 SILLTHDGRVKLSDFGFCAQVSKEVPRRKSL-VGTPYWMAPELISRLPYGPEVDIWSLGV 505 Query: 68 VLVELISSKP 39 +++E++ +P Sbjct: 506 MVIEMVDGEP 515
>KPCE_MOUSE (P16054) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 58.9 bits (141), Expect = 6e-09 Identities = 43/140 (30%), Positives = 65/140 (46%) Frame = -2 Query: 458 LYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 LY C R L V E++ G + + R + P A E AL +LH Sbjct: 472 LYCCFQTKDR-LFFVMEYVNGGDLMFQIQRSRKFDE----PRSRFYAAEVTSALMFLHQH 526 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT 99 +I+RD+K NILLD H K+ADFG+ + + +T GTP Y+ P Q + Sbjct: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGIMNGVTTTTF-CGTPDYIAPEILQELEYG 585 Query: 98 DKSDVSTSGVVLVELISSKP 39 D GV++ E+++ +P Sbjct: 586 PSVDWWALGVLMYEMMAGQP 605
>KAPC_DICDI (P34099) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) Length = 648 Score = 58.9 bits (141), Expect = 6e-09 Identities = 39/131 (29%), Positives = 60/131 (45%) Frame = -2 Query: 431 RDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKT 252 + L L++E++A G V HL A E AL +LH I++RD+K Sbjct: 407 KKLYLLFEYVAGGEVFTHLRKSMKFSNSTA----KFYAAEIVLALEFLHKQNIVYRDLKP 462 Query: 251 TNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSG 72 N+L+DN H+K+ DFG F V + GTP Y+ P Q D G Sbjct: 463 ENLLIDNQGHIKITDFG----FAKRVEDRTFTLCGTPEYLAPEIIQSKGHGKAVDWWALG 518 Query: 71 VVLVELISSKP 39 +++ E+++ P Sbjct: 519 ILIFEMLAGYP 529
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 58.9 bits (141), Expect = 6e-09 Identities = 44/141 (31%), Positives = 69/141 (48%), Gaps = 7/141 (4%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHL--HGCRAAERGLTWPLRLNIAIETAEALAYLHPVE 276 C S R+L L+ E++ G++ D+L H R + L L + + + YL Sbjct: 917 CYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKL-----LQYTSQICKGMEYLGTKR 971 Query: 275 IIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD 96 IHRD+ T NIL++N VK+ DFGL+++ P + + PG ++ LT+ Sbjct: 972 YIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKV---KEPGESPIFWYAPESLTE 1028 Query: 95 K-----SDVSTSGVVLVELIS 48 SDV + GVVL EL + Sbjct: 1029 SKFSVASDVWSFGVVLYELFT 1049 Score = 29.6 bits (65), Expect = 4.0 Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 8/84 (9%) Frame = -2 Query: 422 LLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNI 243 +LV EF+ G++ +L + + + +L +A + A A+ +L +IH +V NI Sbjct: 623 ILVQEFVKFGSLDTYL---KKNKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNI 679 Query: 242 LL--------DNSFHVKVADFGLS 195 LL N +K++D G+S Sbjct: 680 LLIREEDRKTGNPPFIKLSDPGIS 703
>AURKB_PIG (Q9N0X0) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-B) (Fragment) Length = 156 Score = 58.9 bits (141), Expect = 6e-09 Identities = 44/139 (31%), Positives = 65/139 (46%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + L+ E+ G + L CR + T I E A+AL Y H ++IHRD+K N Sbjct: 1 IYLILEYAPRGELYKELQKCRTFDEQRT----ATIMEELADALIYCHGKKVIHRDIKPEN 56 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 +LL +K+ADFG S P + +GT Y+ P + +K D+ GV+ Sbjct: 57 LLLGLQGELKIADFGWSVHAP---SLRRKTMRGTLDYLPPEMIEGRTHNEKVDLWCIGVL 113 Query: 65 LVELISSKPGVNMSRSHSE 9 EL+ P S SH+E Sbjct: 114 CYELLVGNPPFE-SASHNE 131
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 58.5 bits (140), Expect = 8e-09 Identities = 41/152 (26%), Positives = 75/152 (49%), Gaps = 13/152 (8%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY ++ + ++ EF+A G++ D L ++ + P ++ + + AE +AY+ Sbjct: 302 VRLYAVVTK-EEPIYIITEFMAKGSLLDFLKSDEGSK--VLLPKLIDFSAQIAEGMAYIE 358 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRL-------------FPLEVTHVSTVPQGT 144 IHRD++ N+L+ S K+ADFGL+R+ FP++ T + G Sbjct: 359 RKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG- 417 Query: 143 PGYVDPVYHQCYKLTDKSDVSTSGVVLVELIS 48 C+ T KSDV + G++L E+++ Sbjct: 418 ----------CF--TIKSDVWSFGILLYEIVT 437
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 58.5 bits (140), Expect = 8e-09 Identities = 43/142 (30%), Positives = 73/142 (51%), Gaps = 3/142 (2%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V EF+ G++ D L + L P +++A + A+ +A++ Sbjct: 333 VPLYAVVSE--EPIYIVTEFMGKGSLLDFLK--EGDGKHLKLPQLVDMASQIADGMAFIE 388 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + IHRD++ NIL+ ++ K+ADFGL+RL + T QG + P Sbjct: 389 RMNYIHRDLRAANILVADNLVCKIADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 445 Query: 113 CYKLTDKSDVSTSGVVLVELIS 48 + T KSDV + G++L EL++ Sbjct: 446 YGRFTIKSDVWSFGILLTELVT 467
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 58.5 bits (140), Expect = 8e-09 Identities = 46/131 (35%), Positives = 65/131 (49%), Gaps = 3/131 (2%) Frame = -2 Query: 431 RDLLLVYEFIANGTVADHL--HGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDV 258 + L LV E+ + G V D+L HG R E+ R + A+ Y H I+HRD+ Sbjct: 130 KTLYLVMEYASGGEVFDYLVAHG-RMKEKEARAKFR-----QIVSAVQYCHQKCIVHRDL 183 Query: 257 KTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT-DKSDVS 81 K N+LLD ++K+ADFG S F V + G+P Y P Q K + DV Sbjct: 184 KAENLLLDADMNIKIADFGFSNEF--TVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 241 Query: 80 TSGVVLVELIS 48 + GV+L L+S Sbjct: 242 SLGVILYTLVS 252
>CD2L7_HUMAN (Q9NYV4) Cell division cycle 2-related protein kinase 7 (EC| 2.7.11.22) (CDC2-related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) Length = 1490 Score = 58.5 bits (140), Expect = 8e-09 Identities = 36/90 (40%), Positives = 50/90 (55%), Gaps = 1/90 (1%) Frame = -2 Query: 305 EALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDP 126 E L Y H +HRD+K +NILL+NS +K+ADFGL+RL+ E + T T Y P Sbjct: 845 EGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPP 904 Query: 125 -VYHQCYKLTDKSDVSTSGVVLVELISSKP 39 + + T DV + G +L EL + KP Sbjct: 905 ELLLGEERYTPAIDVWSCGCILGELFTKKP 934
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 58.5 bits (140), Expect = 8e-09 Identities = 38/126 (30%), Positives = 64/126 (50%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + +V E + +G++ ++L G R L P +++ + A ++YL IHRD+ N Sbjct: 308 IYIVTELMKHGSLLEYLRG---DGRSLKLPDLVDMCSQVASGMSYLEQQNYIHRDLAARN 364 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 IL+ KVADFGL+R+ E+ + + P + T KSDV + G+V Sbjct: 365 ILVGEHKICKVADFGLARVIDEEIYEAKLGAKFPIKWTAPEAAMYSRFTIKSDVWSFGIV 424 Query: 65 LVELIS 48 L E+I+ Sbjct: 425 LYEVIT 430
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 58.5 bits (140), Expect = 8e-09 Identities = 38/139 (27%), Positives = 71/139 (51%), Gaps = 13/139 (9%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + ++ EF+A G++ D L +++ L P ++ + + AE +A++ IHRD++ N Sbjct: 328 IYIITEFMAKGSLLDFLKSDEGSKQPL--PKLIDFSAQIAEGMAFIEQRNYIHRDLRAAN 385 Query: 245 ILLDNSFHVKVADFGLSRL-------------FPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 IL+ S K+ADFGL+R+ FP++ T + G+ Sbjct: 386 ILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGS------------- 432 Query: 104 LTDKSDVSTSGVVLVELIS 48 T KSDV + G++L+E+++ Sbjct: 433 FTIKSDVWSFGILLMEIVT 451
>HIPPO_DROME (Q8T0S6) Serine/threonine-protein kinase hippo (EC 2.7.11.1)| Length = 669 Score = 58.5 bits (140), Expect = 8e-09 Identities = 40/130 (30%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 DL + E+ G+V+D + R ++ LT I +T + L YLH IHRD+K Sbjct: 109 DLWICMEYCGAGSVSDIM---RLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAA 165 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 NILL+ + K+ADFG++ + +TV GTP ++ P + +D+ + G+ Sbjct: 166 NILLNTEGYAKLADFGVAGQLTDTMAKRNTV-IGTPFWMAPEVIEEIGYDCVADIWSLGI 224 Query: 68 VLVELISSKP 39 +E+ KP Sbjct: 225 TALEMAEGKP 234
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 58.5 bits (140), Expect = 8e-09 Identities = 46/131 (35%), Positives = 67/131 (51%), Gaps = 3/131 (2%) Frame = -2 Query: 431 RDLLLVYEFIANGTVADHL--HGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDV 258 + L LV E+ + G V D+L HG R E+ R + A+ Y H I+HRD+ Sbjct: 129 KTLYLVMEYASAGEVFDYLVSHG-RMKEKEARAKFR-----QIVSAVHYCHQKNIVHRDL 182 Query: 257 KTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT-DKSDVS 81 K N+LLD ++K+ADFG S F L + + T G+P Y P Q K + D+ Sbjct: 183 KAENLLLDAEANIKIADFGFSNEFTLG-SKLDTF-CGSPPYAAPELFQGKKYDGPEVDIW 240 Query: 80 TSGVVLVELIS 48 + GV+L L+S Sbjct: 241 SLGVILYTLVS 251
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 58.5 bits (140), Expect = 8e-09 Identities = 46/131 (35%), Positives = 67/131 (51%), Gaps = 3/131 (2%) Frame = -2 Query: 431 RDLLLVYEFIANGTVADHL--HGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDV 258 + L LV E+ + G V D+L HG R E+ R + A+ Y H I+HRD+ Sbjct: 129 KTLYLVMEYASAGEVFDYLVSHG-RMKEKEARAKFR-----QIVSAVHYCHQKNIVHRDL 182 Query: 257 KTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT-DKSDVS 81 K N+LLD ++K+ADFG S F L + + T G+P Y P Q K + D+ Sbjct: 183 KAENLLLDAEANIKIADFGFSNEFTLG-SKLDTF-CGSPPYAAPELFQGKKYDGPEVDIW 240 Query: 80 TSGVVLVELIS 48 + GV+L L+S Sbjct: 241 SLGVILYTLVS 251
>PAK1_MOUSE (O88643) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) Length = 545 Score = 58.5 bits (140), Expect = 8e-09 Identities = 40/130 (30%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++A G++ D + E + R E +AL +LH ++IHRD+K+ Sbjct: 339 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR-----ECLQALEFLHSNQVIHRDIKSD 393 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 NILL VK+ DFG E + ST+ GTP ++ P K D+ + G+ Sbjct: 394 NILLGMDGSVKLTDFGFCAQITPEQSKRSTM-VGTPYWMAPEVVTRKAYGPKVDIWSLGI 452 Query: 68 VLVELISSKP 39 + +E+I +P Sbjct: 453 MAIEMIEGEP 462
>PAK1_HUMAN (Q13153) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 58.5 bits (140), Expect = 8e-09 Identities = 40/130 (30%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++A G++ D + E + R E +AL +LH ++IHRD+K+ Sbjct: 339 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR-----ECLQALEFLHSNQVIHRDIKSD 393 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 NILL VK+ DFG E + ST+ GTP ++ P K D+ + G+ Sbjct: 394 NILLGMDGSVKLTDFGFCAQITPEQSKRSTM-VGTPYWMAPEVVTRKAYGPKVDIWSLGI 452 Query: 68 VLVELISSKP 39 + +E+I +P Sbjct: 453 MAIEMIEGEP 462
>HCK_MACFA (Q95M30) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 503 Score = 58.5 bits (140), Expect = 8e-09 Identities = 38/139 (27%), Positives = 71/139 (51%), Gaps = 13/139 (9%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + ++ EF+A G++ D L +++ L P ++ + + AE +A++ IHRD++ N Sbjct: 306 IYIITEFMAKGSLLDFLKSDEGSKQPL--PKLIDFSAQIAEGMAFIEQRNYIHRDLRAAN 363 Query: 245 ILLDNSFHVKVADFGLSRL-------------FPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 IL+ S K+ADFGL+R+ FP++ T + G+ Sbjct: 364 ILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSS------------ 411 Query: 104 LTDKSDVSTSGVVLVELIS 48 T KSDV + G++L+E+++ Sbjct: 412 -TIKSDVWSFGILLMEIVT 429
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 58.5 bits (140), Expect = 8e-09 Identities = 44/139 (31%), Positives = 65/139 (46%), Gaps = 5/139 (3%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHL--HGCRAAERGLTWPLRLNIAIETAEALAYLHPVE 276 C + + + LV E++ G++ D+L H A+ L A + E +AYLH Sbjct: 959 CEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQL-------LLFAQQICEGMAYLHAQH 1011 Query: 275 IIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQCYK 105 IHRD+ N+LLDN VK+ DFGL++ P + G Y +C K Sbjct: 1012 YIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEC-K 1070 Query: 104 LTDKSDVSTSGVVLVELIS 48 SDV + GV L EL++ Sbjct: 1071 FYYASDVWSFGVTLYELLT 1089 Score = 32.3 bits (72), Expect = 0.62 Identities = 32/114 (28%), Positives = 55/114 (48%), Gaps = 8/114 (7%) Frame = -2 Query: 458 LYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 L+G R S +++ V EF+ +G + L R + +TW ++ +A + A AL+YL Sbjct: 666 LHGVCVRGSENII-VTEFVEHGPLDVWLRRQRG-QVPMTW--KMVVAQQLASALSYLEDK 721 Query: 278 EIIHRDVKTTNILL--------DNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP 141 ++H +V NILL N F +K++D G+ + V +P P Sbjct: 722 NLVHGNVCGRNILLARLGLEEGTNPF-IKLSDPGVGQGALSREERVERIPWTAP 774
>PAK1_RAT (P35465) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) Length = 544 Score = 58.5 bits (140), Expect = 8e-09 Identities = 40/130 (30%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++A G++ D + E + R E +AL +LH ++IHRD+K+ Sbjct: 338 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR-----ECLQALEFLHSNQVIHRDIKSD 392 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 NILL VK+ DFG E + ST+ GTP ++ P K D+ + G+ Sbjct: 393 NILLGMDGSVKLTDFGFCAQITPEQSKRSTM-VGTPYWMAPEVVTRKAYGPKVDIWSLGI 451 Query: 68 VLVELISSKP 39 + +E+I +P Sbjct: 452 MAIEMIEGEP 461
>KPC4_DROME (P83099) Putative protein kinase C, delta type homolog (EC| 2.7.11.13) Length = 643 Score = 58.5 bits (140), Expect = 8e-09 Identities = 41/135 (30%), Positives = 65/135 (48%), Gaps = 2/135 (1%) Frame = -2 Query: 449 CTSRMSRDLLLVYEFIANGTVADHLH--GCRAAERGLTWPLRLNIAIETAEALAYLHPVE 276 CT + L V E++ G + H+ G + ER + E L +LH Sbjct: 381 CTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFY------GAEIISGLKFLHKKG 434 Query: 275 IIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD 96 II+RD+K N+LLD HV++ADFG+ +L + + + GTP Y+ P + K Sbjct: 435 IIYRDLKLDNVLLDYEGHVRIADFGMCKL-QIYLDKTADSFCGTPDYMAPEIIKGEKYNQ 493 Query: 95 KSDVSTSGVVLVELI 51 D + GV+L E++ Sbjct: 494 NVDWWSFGVLLYEML 508
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 58.5 bits (140), Expect = 8e-09 Identities = 39/139 (28%), Positives = 69/139 (49%), Gaps = 13/139 (9%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + ++ E++ NG++ D L + LT L++A + E +A+L IHRD++ N Sbjct: 311 IYIITEYMENGSLVDFLKTPSGIK--LTINKLLDMAAQIVEGMAFLEERNYIHRDLRAAN 368 Query: 245 ILLDNSFHVKVADFGLSRL-------------FPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 IL+ ++ K+ADFGL+RL FP++ T + GT Sbjct: 369 ILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGT------------- 415 Query: 104 LTDKSDVSTSGVVLVELIS 48 T KSDV + G+++ E+++ Sbjct: 416 FTIKSDVWSFGILMTEIVT 434
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 58.5 bits (140), Expect = 8e-09 Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 13/139 (9%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + ++ E++ NG++ D L + + L++A + AE +A++ IHRD++ N Sbjct: 311 IYIITEYMENGSLVDFLKTPSGIKLNVN--KLLDMAAQIAEGMAFIEEQNYIHRDLRAAN 368 Query: 245 ILLDNSFHVKVADFGLSRL-------------FPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 IL+ ++ K+ADFGL+RL FP++ T + GT Sbjct: 369 ILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGT------------- 415 Query: 104 LTDKSDVSTSGVVLVELIS 48 T KSDV + G++L E+++ Sbjct: 416 FTIKSDVWSFGILLTEIVT 434
>KPCE_RAT (P09216) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 58.5 bits (140), Expect = 8e-09 Identities = 44/140 (31%), Positives = 65/140 (46%) Frame = -2 Query: 458 LYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 LY C R L V E++ G + + R + P A E AL +LH Sbjct: 472 LYCCFQTKDR-LFFVMEYVNGGDLMFQIQRSRKFDE----PRSGFYAAEVTSALMFLHQH 526 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT 99 +I+RD+K NILLD H K+ADFG+ + L +T GTP Y+ P Q + Sbjct: 527 GVIYRDLKLDNILLDAEGHSKLADFGMCKEGILNGVTTTTF-CGTPDYIAPEILQELEYG 585 Query: 98 DKSDVSTSGVVLVELISSKP 39 D GV++ E+++ +P Sbjct: 586 PSVDWWALGVLMYEMMAGQP 605
>KPC1_LYTPI (Q25378) Protein kinase C (EC 2.7.11.13)| Length = 658 Score = 58.5 bits (140), Expect = 8e-09 Identities = 43/140 (30%), Positives = 63/140 (45%) Frame = -2 Query: 458 LYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPV 279 L+ C M R L V EF+ G + + P + A E A L YLH Sbjct: 389 LHSCFQTMDR-LFFVMEFVNGGDLMFQIQKVGKFRE----PHAVFYAAEIAVGLFYLHSQ 443 Query: 278 EIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT 99 +I+RD+K N+L+D H+K+ADFG+ + E T GTP Y+ P Sbjct: 444 GVIYRDLKLDNVLVDAEGHIKIADFGMCKEHMNEGDTTRTF-CGTPDYIAPEIVAYQPYG 502 Query: 98 DKSDVSTSGVVLVELISSKP 39 D GV+L E+++ +P Sbjct: 503 KAVDWWAFGVLLYEMLAGQP 522
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 58.5 bits (140), Expect = 8e-09 Identities = 37/126 (29%), Positives = 68/126 (53%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + +V E++A G + D L + L+ P ++++ + AE +AY+ + IHRD++ N Sbjct: 307 IYIVTEYMARGCLLDFLKTDEGSR--LSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAAN 364 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 IL+ + K+ADFGL+R+ E T + + P T K+DV + GV+ Sbjct: 365 ILVSEALCCKIADFGLARIIDSEYT-AQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVL 423 Query: 65 LVELIS 48 L+E+++ Sbjct: 424 LMEVVT 429
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 58.5 bits (140), Expect = 8e-09 Identities = 46/131 (35%), Positives = 65/131 (49%), Gaps = 3/131 (2%) Frame = -2 Query: 431 RDLLLVYEFIANGTVADHL--HGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDV 258 + L LV E+ + G V D+L HG R E+ R + A+ Y H I+HRD+ Sbjct: 130 KTLYLVMEYASGGEVFDYLVAHG-RMKEKEARAKFR-----QIVSAVQYCHQKCIVHRDL 183 Query: 257 KTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT-DKSDVS 81 K N+LLD ++K+ADFG S F V + G+P Y P Q K + DV Sbjct: 184 KAENLLLDADMNIKIADFGFSNEF--TVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 241 Query: 80 TSGVVLVELIS 48 + GV+L L+S Sbjct: 242 SLGVILYTLVS 252
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 58.5 bits (140), Expect = 8e-09 Identities = 39/126 (30%), Positives = 73/126 (57%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 ++ E+ A+G + + L A R +T L ++ + A + YLH +IIHRD+K+ N+L Sbjct: 231 IIMEYCAHGQLYEVLR----AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVL 286 Query: 239 LDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLV 60 + ++ VK++DFG S+ + T +S GT ++ P + +++K D+ + GVVL Sbjct: 287 VTHTDAVKISDFGTSKELSDKSTKMSFA--GTVAWLAPEVIRNEPVSEKVDIWSFGVVLW 344 Query: 59 ELISSK 42 EL++ + Sbjct: 345 ELLTGE 350
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 58.5 bits (140), Expect = 8e-09 Identities = 39/126 (30%), Positives = 73/126 (57%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 ++ E+ A+G + + L A R +T L ++ + A + YLH +IIHRD+K+ N+L Sbjct: 231 IIMEYCAHGQLYEVLR----AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVL 286 Query: 239 LDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLV 60 + ++ VK++DFG S+ + T +S GT ++ P + +++K D+ + GVVL Sbjct: 287 VTHTDAVKISDFGTSKELSDKSTKMSFA--GTVAWMAPEVIRNEPVSEKVDIWSFGVVLW 344 Query: 59 ELISSK 42 EL++ + Sbjct: 345 ELLTGE 350
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 58.2 bits (139), Expect = 1e-08 Identities = 41/152 (26%), Positives = 74/152 (48%), Gaps = 13/152 (8%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY ++ + ++ EF+A G++ D L + + P ++ + + AE +AY+ Sbjct: 302 VRLYAVVTK-EEPIYIITEFMAKGSLLDFLKSDEGGK--VLLPKLIDFSAQIAEGMAYIE 358 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRL-------------FPLEVTHVSTVPQGT 144 IHRD++ N+L+ S K+ADFGL+R+ FP++ T + G Sbjct: 359 RKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG- 417 Query: 143 PGYVDPVYHQCYKLTDKSDVSTSGVVLVELIS 48 C+ T KSDV + G++L E+++ Sbjct: 418 ----------CF--TIKSDVWSFGILLYEIVT 437
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 58.2 bits (139), Expect = 1e-08 Identities = 41/152 (26%), Positives = 74/152 (48%), Gaps = 13/152 (8%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY +R + ++ E++A G++ D L + + P ++ + + AE +AY+ Sbjct: 302 VRLYAVVTR-EEPIYIITEYMAKGSLLDFLKSDEGGK--VLLPKLIDFSAQIAEGMAYIE 358 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRL-------------FPLEVTHVSTVPQGT 144 IHRD++ N+L+ S K+ADFGL+R+ FP++ T + G Sbjct: 359 RKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG- 417 Query: 143 PGYVDPVYHQCYKLTDKSDVSTSGVVLVELIS 48 C+ T KSDV + G++L E+++ Sbjct: 418 ----------CF--TIKSDVWSFGILLYEIVT 437
>AKT1_DROME (Q8INB9) RAC serine/threonine-protein kinase (EC 2.7.11.1)| (DRAC-PK) (Akt) (Dakt1) (Protein kinase B) (PKB) Length = 611 Score = 58.2 bits (139), Expect = 1e-08 Identities = 44/130 (33%), Positives = 62/130 (47%), Gaps = 2/130 (1%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L V +++ G + HL + ER T E AL YLH II+RD+K N Sbjct: 339 LCFVMQYVNGGELFWHL----SHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLEN 394 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQ--GTPGYVDPVYHQCYKLTDKSDVSTSG 72 +LLD H+KVADFGL + ++T+ T GTP Y+ P D +G Sbjct: 395 LLLDKDGHIKVADFGLCK---EDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTG 451 Query: 71 VVLVELISSK 42 VV+ E+I + Sbjct: 452 VVMYEMICGR 461
>SGK2_HUMAN (Q9HBY8) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) Length = 427 Score = 58.2 bits (139), Expect = 1e-08 Identities = 43/129 (33%), Positives = 60/129 (46%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L V +++ G + HL ER P A E A A+ YLH + II+RD+K N Sbjct: 169 LYFVLDYVNGGELFFHLQ----RERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPEN 224 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 ILLD HV + DFGL + +E ++ GTP Y+ P + D G V Sbjct: 225 ILLDCQGHVVLTDFGLCK-EGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAV 283 Query: 65 LVELISSKP 39 L E++ P Sbjct: 284 LYEMLHGLP 292
>MST4_MOUSE (Q99JT2) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) Length = 416 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/140 (30%), Positives = 70/140 (50%), Gaps = 1/140 (0%) Frame = -2 Query: 455 YGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE 276 YG + S+ L ++ E++ G+ D L E + L+ E + L YLH + Sbjct: 86 YGSYLKGSK-LWIIMEYLGGGSALDLLRAGPFDEFQIATMLK-----EILKGLDYLHSEK 139 Query: 275 IIHRDVKTTNILLDNSFHVKVADFGLS-RLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT 99 IHRD+K N+LL VK+ADFG++ +L ++ + V GTP ++ P Q Sbjct: 140 KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV--GTPFWMAPEVIQQSAYD 197 Query: 98 DKSDVSTSGVVLVELISSKP 39 K+D+ + G+ +EL +P Sbjct: 198 SKADIWSLGITAIELAKGEP 217
>MST4_HUMAN (Q9P289) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase) Length = 416 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/140 (30%), Positives = 70/140 (50%), Gaps = 1/140 (0%) Frame = -2 Query: 455 YGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVE 276 YG + S+ L ++ E++ G+ D L E + L+ E + L YLH + Sbjct: 86 YGSYLKGSK-LWIIMEYLGGGSALDLLRAGPFDEFQIATMLK-----EILKGLDYLHSEK 139 Query: 275 IIHRDVKTTNILLDNSFHVKVADFGLS-RLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLT 99 IHRD+K N+LL VK+ADFG++ +L ++ + V GTP ++ P Q Sbjct: 140 KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV--GTPFWMAPEVIQQSAYD 197 Query: 98 DKSDVSTSGVVLVELISSKP 39 K+D+ + G+ +EL +P Sbjct: 198 SKADIWSLGITAIELAKGEP 217
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 58.2 bits (139), Expect = 1e-08 Identities = 37/124 (29%), Positives = 67/124 (54%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNIL 240 ++ E ++ G++ D+L G A L P +++A + A +AYL IHRD+ NIL Sbjct: 165 IITELMSKGSLLDYLQGEAGA---LKLPQLIDMAAQVAAGMAYLELHNYIHRDLAARNIL 221 Query: 239 LDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLV 60 + ++ KVADFGL+RL + + + + + P + + KSDV + G+++ Sbjct: 222 VGDNNICKVADFGLARLIVSDDYNATEGAKFPIKWTAPEAALFNRFSIKSDVWSFGILIT 281 Query: 59 ELIS 48 EL++ Sbjct: 282 ELVT 285
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 58.2 bits (139), Expect = 1e-08 Identities = 38/139 (27%), Positives = 71/139 (51%), Gaps = 13/139 (9%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + +V EF+A G++ D L +++ L P ++ + + +E +A++ IHRD++ N Sbjct: 305 IFIVTEFMAKGSLLDFLKSEEGSKQPL--PKLIDFSAQISEGMAFIEQRNYIHRDLRAAN 362 Query: 245 ILLDNSFHVKVADFGLSRL-------------FPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 IL+ S K+ADFGL+R+ FP++ T + G+ Sbjct: 363 ILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGS------------- 409 Query: 104 LTDKSDVSTSGVVLVELIS 48 T KSDV + G++L+E+++ Sbjct: 410 FTIKSDVWSFGILLMEIVT 428
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 58.2 bits (139), Expect = 1e-08 Identities = 43/139 (30%), Positives = 68/139 (48%), Gaps = 2/139 (1%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERG--LTWPLRLNIAIETAEALAY 291 V LY S + +V E+++ G++ D L G E G L P + +A + A +AY Sbjct: 319 VQLYAMVSE--EPIYIVIEYMSKGSLLDFLKG----EMGKYLRLPQLVEMAAQIASGMAY 372 Query: 290 LHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQC 111 + + +HRD++ NIL+ + KVADFGL+RL + + P Sbjct: 373 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARPGARFPVKWTAPEAALY 432 Query: 110 YKLTDKSDVSTSGVVLVEL 54 + T KSDV + G++L EL Sbjct: 433 GRFTIKSDVWSFGILLTEL 451
>KPC1_APLCA (Q16974) Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I)| Length = 649 Score = 58.2 bits (139), Expect = 1e-08 Identities = 46/144 (31%), Positives = 70/144 (48%), Gaps = 2/144 (1%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V L+ C M R L V E++ G + + E P+ A E A L YLH Sbjct: 382 VQLHSCFQTMDR-LYFVMEYVNGGDLMYRIQ----QEGKFKEPVAAFYAAEIAIGLFYLH 436 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDP--VYHQC 111 I++RD+K N++LD H+K+ADFG+ + + T GTP Y+ P V +Q Sbjct: 437 TQGIVYRDLKLDNVMLDAEGHIKIADFGMCKENIMGDKTTRTF-CGTPDYIAPEIVLYQP 495 Query: 110 YKLTDKSDVSTSGVVLVELISSKP 39 Y + D GV+L E+++ +P Sbjct: 496 YGRS--VDWWAYGVLLYEMLAGQP 517
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 58.2 bits (139), Expect = 1e-08 Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 3/142 (2%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V EF++ G++ D L + L P +++A + A+ +AY+ Sbjct: 332 VPLYAVVSE--EPIYIVTEFMSKGSLLDFLK--EGDGKYLKLPQLVDMAAQIADGMAYIE 387 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + IHRD++ NIL+ + K+ADFGL+RL + T QG + P Sbjct: 388 RMNYIHRDLRAANILVGENLVCKIADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 444 Query: 113 CYKLTDKSDVSTSGVVLVELIS 48 + T KSDV + G++ EL++ Sbjct: 445 YGRFTIKSDVWSFGILQTELVT 466
>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)| (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase) Length = 944 Score = 58.2 bits (139), Expect = 1e-08 Identities = 41/132 (31%), Positives = 65/132 (49%), Gaps = 3/132 (2%) Frame = -2 Query: 434 SRDLLLVYEFIANGTVADHLHGCRAA---ERGLTWPLRLNIAIETAEALAYLHPVEIIHR 264 S LL+ E+ G + D + +A E + W L + A++ +H I+HR Sbjct: 103 SNTLLIELEYCNGGNLFDKIVHQKAQLFQEETVLWYL-----FQIVSAVSCIHKAGILHR 157 Query: 263 DVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDV 84 D+KT NI L + +K+ D+GL++ E + T GT Y+ P Q K + KSD+ Sbjct: 158 DIKTLNIFLTKANLIKLGDYGLAKQLSSEYSMAETC-VGTLYYMSPEICQGVKYSFKSDI 216 Query: 83 STSGVVLVELIS 48 G VL EL++ Sbjct: 217 WAVGCVLYELLT 228
>STK10_HUMAN (O94804) Serine/threonine-protein kinase 10 (EC 2.7.11.1)| (Lymphocyte-oriented kinase) Length = 968 Score = 58.2 bits (139), Expect = 1e-08 Identities = 39/123 (31%), Positives = 62/123 (50%), Gaps = 5/123 (4%) Frame = -2 Query: 356 ERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLE 177 +RGLT P + + EAL +LH IIHRD+K N+L+ +++ADFG+S L+ Sbjct: 126 DRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAK-NLK 184 Query: 176 VTHVSTVPQGTPGYVDPVYHQCYKLTD-----KSDVSTSGVVLVELISSKPGVNMSRSHS 12 GTP ++ P C + D K+D+ + G+ L+E+ +P H Sbjct: 185 TLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEP------PHH 238 Query: 11 EIN 3 E+N Sbjct: 239 ELN 241
>RK_MOUSE (Q9WVL4) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 564 Score = 58.2 bits (139), Expect = 1e-08 Identities = 36/129 (27%), Positives = 64/129 (49%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 DL LV + G V H++ G + P + + L +LH I++RD+K Sbjct: 262 DLCLVMTIMNGGDVRYHIYNVDEDNPGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPE 321 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 N+LLDN +++++D GL+ + E + + GTPG++ P + + D GV Sbjct: 322 NVLLDNDGNIRISDLGLA-VELKEGQNKTKGYAGTPGFMAPELLRGEEYDFSVDYFALGV 380 Query: 68 VLVELISSK 42 L E+I+++ Sbjct: 381 TLYEMIAAR 389
>PKNA2_BIFLO (Q8G4G1) Probable serine/threonine-protein kinase pknA2 (EC| 2.7.11.1) Length = 757 Score = 58.2 bits (139), Expect = 1e-08 Identities = 28/96 (29%), Positives = 53/96 (55%) Frame = -2 Query: 329 LNIAIETAEALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQ 150 L + ET + LA H ++HRD+K NIL+++ HV++ DFGL++ + + Sbjct: 118 LRVVAETLDGLASAHRAGVVHRDIKPENILINDRGHVQITDFGLAKAASQATLSSTGMLL 177 Query: 149 GTPGYVDPVYHQCYKLTDKSDVSTSGVVLVELISSK 42 GT Y+ P + + T + D+ + G++ E+++ K Sbjct: 178 GTAAYLAPEMIENNQATAQGDLYSVGIMAWEMLTGK 213
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 58.2 bits (139), Expect = 1e-08 Identities = 41/138 (29%), Positives = 66/138 (47%), Gaps = 13/138 (9%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L + E+I GT+ + ++ + W R++ A + A +AYLH + IIHRD+ + N Sbjct: 409 LNFITEYIKGGTLRGII---KSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHN 465 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQ-------------GTPGYVDPVYHQCYK 105 L+ + +V VADFGL+RL E + G P ++ P Sbjct: 466 CLVRENRNVVVADFGLARLMIDEKGQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRS 525 Query: 104 LTDKSDVSTSGVVLVELI 51 +K DV + G+VL E+I Sbjct: 526 YDEKVDVFSFGIVLCEII 543
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 58.2 bits (139), Expect = 1e-08 Identities = 36/130 (27%), Positives = 64/130 (49%) Frame = -2 Query: 437 MSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDV 258 + + +V E + G + +L + L+ P L A + AE ++YL ++HRD+ Sbjct: 298 LGEPVYIVTELMGKGNLQVYLGSSEG--KALSLPHLLGFACQVAEGMSYLEERRVVHRDL 355 Query: 257 KTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVST 78 N+L+ + KVADFGL+RL +V S+ + + P + KSDV + Sbjct: 356 AARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWS 415 Query: 77 SGVVLVELIS 48 G++L E+ + Sbjct: 416 FGILLYEVFT 425
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 58.2 bits (139), Expect = 1e-08 Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 3/142 (2%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V LY S + +V EF++ G++ D L + L P +++A + A+ +AY+ Sbjct: 330 VPLYAVVSE--EPIYIVTEFMSKGSLLDFLK--EGDGKYLKLPQLVDMAAQIADGMAYIE 385 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTP---GYVDPVYHQ 114 + IHRD++ NIL+ + K+ADFGL+RL + T QG + P Sbjct: 386 RMNYIHRDLRAANILVGENLICKIADFGLARLIE---DNEYTARQGAKFPIKWTAPEAAL 442 Query: 113 CYKLTDKSDVSTSGVVLVELIS 48 + T KSDV + G++ EL++ Sbjct: 443 YGRFTIKSDVWSFGILQTELVT 464
>NEK4_HUMAN (P51957) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Length = 841 Score = 58.2 bits (139), Expect = 1e-08 Identities = 35/102 (34%), Positives = 51/102 (50%) Frame = -2 Query: 317 IETAEALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPG 138 ++ A AL YLH I+HRD+KT N+ L + +KV D G++R+ ST+ GTP Sbjct: 113 VQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTL-IGTPY 171 Query: 137 YVDPVYHQCYKLTDKSDVSTSGVVLVELISSKPGVNMSRSHS 12 Y+ P KSDV G + E+ + K N +S Sbjct: 172 YMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNS 213
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 58.2 bits (139), Expect = 1e-08 Identities = 38/139 (27%), Positives = 71/139 (51%), Gaps = 13/139 (9%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + +V EF+A G++ D L +++ L P ++ + + +E +A++ IHRD++ N Sbjct: 326 IFIVTEFMAKGSLLDFLKSEEGSKQPL--PKLIDFSAQISEGMAFIEQRNYIHRDLRAAN 383 Query: 245 ILLDNSFHVKVADFGLSRL-------------FPLEVTHVSTVPQGTPGYVDPVYHQCYK 105 IL+ S K+ADFGL+R+ FP++ T + G+ Sbjct: 384 ILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGS------------- 430 Query: 104 LTDKSDVSTSGVVLVELIS 48 T KSDV + G++L+E+++ Sbjct: 431 FTIKSDVWSFGILLMEIVT 449
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 58.2 bits (139), Expect = 1e-08 Identities = 44/132 (33%), Positives = 69/132 (52%), Gaps = 6/132 (4%) Frame = -2 Query: 419 LVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH---PVEIIHRDVKTT 249 LV +F+ NG+ L G ++ WPL + E + YLH PV ++HRD+K + Sbjct: 92 LVTKFMENGS----LSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPV-LLHRDLKPS 146 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHV-STVPQGTPGYVDP--VYHQCYKLTDKSDVST 78 N+L D HVK+ADFGLS + S P GT GY+ P + K + SDV + Sbjct: 147 NVLPDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYS 206 Query: 77 SGVVLVELISSK 42 G+++ +++ + Sbjct: 207 FGILMWAVLAGR 218
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 58.2 bits (139), Expect = 1e-08 Identities = 40/135 (29%), Positives = 67/135 (49%), Gaps = 6/135 (4%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 + LV++ + G + D+L + L+ +I EA+++LH I+HRD+K N Sbjct: 103 MFLVFDLMRKGELFDYL----TEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPEN 158 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYK------LTDKSDV 84 ILLD++ ++++DFG S LE GTPGY+ P +C + D+ Sbjct: 159 ILLDDNMQIRLSDFGFS--CHLEAGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDL 216 Query: 83 STSGVVLVELISSKP 39 GV+L L++ P Sbjct: 217 WACGVILFTLLAGSP 231
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 58.2 bits (139), Expect = 1e-08 Identities = 41/127 (32%), Positives = 66/127 (51%), Gaps = 1/127 (0%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRL-NIAIETAEALAYLHPVEIIHRDVKTT 249 + +V E + G++ ++L G E G+ +L ++A + A ++YL IHRD+ Sbjct: 308 IYIVTELMKYGSLLEYLRG----EDGVLKIEQLVDVAAQVASGMSYLEQQNYIHRDLAAR 363 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 NIL+ KVADFGL+R+ E+ T + + P + T KSDV + GV Sbjct: 364 NILVGEHGICKVADFGLARVIDEEIYEAHTGAKFPIKWTAPEAAMYNRFTIKSDVWSFGV 423 Query: 68 VLVELIS 48 VL E+I+ Sbjct: 424 VLYEIIT 430
>KPC2_APLCA (Q16975) Calcium-independent protein kinase C (EC 2.7.11.13) (APL| II) Length = 743 Score = 58.2 bits (139), Expect = 1e-08 Identities = 42/129 (32%), Positives = 60/129 (46%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L V E++ G + + R + P A E AL +LH II+RD+K N Sbjct: 477 LFFVMEYVNGGDLMFQIQRARKFDE----PRARFYAAEVTLALMFLHRHGIIYRDLKLDN 532 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 ILLD H K+ADFG+ + E T GTP Y+ P Q K D GV+ Sbjct: 533 ILLDAEGHCKIADFGMCKEGMTENKLTQTF-CGTPDYIAPEILQELKYDASVDWWALGVL 591 Query: 65 LVELISSKP 39 + E+++ +P Sbjct: 592 MYEMMAGQP 600
>MAST2_MOUSE (Q60592) Microtubule-associated serine/threonine-protein kinase 2| (EC 2.7.11.1) Length = 1734 Score = 58.2 bits (139), Expect = 1e-08 Identities = 41/127 (32%), Positives = 62/127 (48%), Gaps = 14/127 (11%) Frame = -2 Query: 464 VILYGCTSRMSRDLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLH 285 V+ C+ R L +V E++ G A L A + +RL A ET AL YLH Sbjct: 513 VVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDM---VRLYFA-ETVLALEYLH 568 Query: 284 PVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVT------HVSTVPQ--------G 147 I+HRD+K N+L+ + H+K+ DFGLS++ + +T H+ + G Sbjct: 569 NYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCG 628 Query: 146 TPGYVDP 126 TP Y+ P Sbjct: 629 TPEYIAP 635
>NEK3_MOUSE (Q9R0A5) Serine/threonine-protein kinase Nek3 (EC 2.7.11.1)| (NimA-related protein kinase 3) Length = 511 Score = 57.8 bits (138), Expect = 1e-08 Identities = 32/96 (33%), Positives = 52/96 (54%) Frame = -2 Query: 329 LNIAIETAEALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQ 150 LN I+ + ++H ++HRD+K+ N+ L ++ VK+ DFG +RL + T Sbjct: 103 LNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKVKLGDFGSARLLSSPMAFACTY-V 161 Query: 149 GTPGYVDPVYHQCYKLTDKSDVSTSGVVLVELISSK 42 GTP YV P + +KSD+ + G +L EL + K Sbjct: 162 GTPYYVPPEIWENLPYNNKSDIWSLGCILYELCALK 197
>SULU_CAEEL (P46549) Serine/threonine-protein kinase SULU (EC 2.7.11.1)| (Protein kinase 18) Length = 982 Score = 57.8 bits (138), Expect = 1e-08 Identities = 35/98 (35%), Positives = 53/98 (54%), Gaps = 3/98 (3%) Frame = -2 Query: 323 IAIETAEALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGT 144 I +T +AL YLH ++ IHRD+K NILL + VK+ADFG + L T + GT Sbjct: 133 ICSQTLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSASLVDPAQTFI-----GT 187 Query: 143 PGYVDPVYHQCY---KLTDKSDVSTSGVVLVELISSKP 39 P ++ P TD++D+ + G+ +EL +P Sbjct: 188 PFFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRP 225
>SLK_HUMAN (Q9H2G2) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9) Length = 1235 Score = 57.8 bits (138), Expect = 1e-08 Identities = 47/147 (31%), Positives = 70/147 (47%), Gaps = 5/147 (3%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L ++ EF A G V + ER LT + +T +AL YLH +IIHRD+K Sbjct: 103 NLWILIEFCAGGAVDAVM---LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAG 159 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD-----KSDV 84 NIL +K+ADFG+S + + GTP ++ P C D K+DV Sbjct: 160 NILFTLDGDIKLADFGVSAKNTRTIQRRDSF-IGTPYWMAPEVVMCETSKDRPYDYKADV 218 Query: 83 STSGVVLVELISSKPGVNMSRSHSEIN 3 + G+ L+E+ +P H E+N Sbjct: 219 WSLGITLIEMAEIEP------PHHELN 239
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 57.8 bits (138), Expect = 1e-08 Identities = 33/104 (31%), Positives = 56/104 (53%), Gaps = 4/104 (3%) Frame = -2 Query: 347 LTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTNILL---DNSFHVKVADFGLSRLFP-L 180 L W +R+ +A + A L+YLH I HRD+ + N L+ +N + VADFGL+ P Sbjct: 148 LPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDA 207 Query: 179 EVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVVLVELIS 48 + G+P ++ P + +K+DV + G++L E+I+ Sbjct: 208 SIGREKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIA 251
>KOIA_SCHPO (Q9Y7J6) Putative serine/threonine-protein kinase C1778.10c (EC| 2.7.11.1) Length = 550 Score = 57.8 bits (138), Expect = 1e-08 Identities = 33/100 (33%), Positives = 51/100 (51%), Gaps = 6/100 (6%) Frame = -2 Query: 320 AIETAEALAYLHPVEIIHRDVKTTNILLDNSFHVKVADFGLSRLFPLEVTH---VSTVPQ 150 A E ++ Y+H IIHRD+K NIL D + HVK+ DFG +++ P + + +T P Sbjct: 159 AAEILSSIEYMHSCGIIHRDLKPENILFDGNMHVKITDFGTAKILPPKYVNSPDYTTFPS 218 Query: 149 ---GTPGYVDPVYHQCYKLTDKSDVSTSGVVLVELISSKP 39 GT YV P ++ SD+ V+ ++I P Sbjct: 219 SFVGTAEYVAPELLSRQVVSKSSDLWAFACVVYQMIVGSP 258
>MINK1_MOUSE (Q9JM52) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1308 Score = 57.8 bits (138), Expect = 1e-08 Identities = 42/134 (31%), Positives = 63/134 (47%), Gaps = 5/134 (3%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L LV EF G+V D + + L I E LA+LH ++IHRD+K N Sbjct: 101 LWLVMEFCGAGSVTDLVKNTKG--NALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQN 158 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD-----KSDVS 81 +LL + VK+ DFG+S V +T GTP ++ P C + D +SD+ Sbjct: 159 VLLTENAEVKLVDFGVSAQLDRTVGRRNTF-IGTPYWMAPEVIACDENPDATYDYRSDIW 217 Query: 80 TSGVVLVELISSKP 39 + G+ +E+ P Sbjct: 218 SLGITAIEMAEGAP 231
>RK_RAT (Q63651) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 564 Score = 57.8 bits (138), Expect = 1e-08 Identities = 36/129 (27%), Positives = 63/129 (48%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 DL LV + G V H++ G P + + L +LH I++RD+K Sbjct: 262 DLCLVMTIMNGGDVRYHIYNVDEENPGFPEPRAIYYTAQIISGLEHLHQRRIVYRDLKPE 321 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 N+LLDN +++++D GL+ + E + + GTPG++ P + + D GV Sbjct: 322 NVLLDNDGNIRISDLGLA-VELKEGQNKTKGYAGTPGFMAPELLRGEEYDFSVDYFALGV 380 Query: 68 VLVELISSK 42 L E+I+++ Sbjct: 381 TLYEMIAAR 389
>MYO3A_HUMAN (Q8NEV4) Myosin IIIA (EC 2.7.11.1)| Length = 1616 Score = 57.8 bits (138), Expect = 1e-08 Identities = 43/134 (32%), Positives = 59/134 (44%), Gaps = 5/134 (3%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L LV E + G+V D + G ++ PL I E L +LH + IHRDVK N Sbjct: 96 LWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNN 155 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD-----KSDVS 81 ILL VK+ DFG+S H GTP ++ P C + D + D Sbjct: 156 ILLTTEGGVKLVDFGVSAQL-TSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTW 214 Query: 80 TSGVVLVELISSKP 39 + G+ +EL P Sbjct: 215 SLGITAIELGDGDP 228
>MINK1_HUMAN (Q8N4C8) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1332 Score = 57.8 bits (138), Expect = 1e-08 Identities = 42/134 (31%), Positives = 63/134 (47%), Gaps = 5/134 (3%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L LV EF G+V D + + L I E LA+LH ++IHRD+K N Sbjct: 101 LWLVMEFCGAGSVTDLVKNTKG--NALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQN 158 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTD-----KSDVS 81 +LL + VK+ DFG+S V +T GTP ++ P C + D +SD+ Sbjct: 159 VLLTENAEVKLVDFGVSAQLDRTVGRRNTF-IGTPYWMAPEVIACDENPDATYDYRSDIW 217 Query: 80 TSGVVLVELISSKP 39 + G+ +E+ P Sbjct: 218 SLGITAIEMAEGAP 231
>PK2_DICDI (P28178) Protein kinase 2 (EC 2.7.11.1)| Length = 479 Score = 57.8 bits (138), Expect = 1e-08 Identities = 41/129 (31%), Positives = 64/129 (49%) Frame = -2 Query: 425 LLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTTN 246 L +V +F+ G + HL E + P A E AL +LH +I++RD+K N Sbjct: 226 LYMVLDFVNGGELFFHLK----REGRFSEPRVKIYAAEIVSALDHLHKQDIVYRDLKPEN 281 Query: 245 ILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGVV 66 ILLD+ H+ + DFGLS+ +E T + GTP Y+ P + D + G + Sbjct: 282 ILLDSEGHICITDFGLSK--KIETTDGTFTFCGTPEYLAPEVLNGHGHGCAVDWWSLGTL 339 Query: 65 LVELISSKP 39 L E+++ P Sbjct: 340 LYEMLTGLP 348
>PAK3_PONPY (Q7YQL3) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/130 (30%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++A G++ D + E + R E +AL +LH ++IHRD+K+ Sbjct: 352 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR-----ECLQALDFLHSNQVIHRDIKSD 406 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 NILL VK+ DFG E + ST+ GTP ++ P K D+ + G+ Sbjct: 407 NILLGMDGSVKLTDFGFCAQITPEQSKRSTM-VGTPYWMAPEVVTRKAYGPKVDIWSLGI 465 Query: 68 VLVELISSKP 39 + +E++ +P Sbjct: 466 MAIEMVEGEP 475
>PAK3_PANTR (Q7YQL4) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/130 (30%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++A G++ D + E + R E +AL +LH ++IHRD+K+ Sbjct: 352 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR-----ECLQALDFLHSNQVIHRDIKSD 406 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 NILL VK+ DFG E + ST+ GTP ++ P K D+ + G+ Sbjct: 407 NILLGMDGSVKLTDFGFCAQITPEQSKRSTM-VGTPYWMAPEVVTRKAYGPKVDIWSLGI 465 Query: 68 VLVELISSKP 39 + +E++ +P Sbjct: 466 MAIEMVEGEP 475
>PAK3_MOUSE (Q61036) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B) Length = 559 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/130 (30%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++A G++ D + E + R E +AL +LH ++IHRD+K+ Sbjct: 352 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR-----ECLQALDFLHSNQVIHRDIKSD 406 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 NILL VK+ DFG E + ST+ GTP ++ P K D+ + G+ Sbjct: 407 NILLGMDGSVKLTDFGFCAQITPEQSKRSTM-VGTPYWMAPEVVTRKAYGPKVDIWSLGI 465 Query: 68 VLVELISSKP 39 + +E++ +P Sbjct: 466 MAIEMVEGEP 475
>PAK3_HUMAN (O75914) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3) Length = 559 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/130 (30%), Positives = 66/130 (50%) Frame = -2 Query: 428 DLLLVYEFIANGTVADHLHGCRAAERGLTWPLRLNIAIETAEALAYLHPVEIIHRDVKTT 249 +L +V E++A G++ D + E + R E +AL +LH ++IHRD+K+ Sbjct: 352 ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR-----ECLQALDFLHSNQVIHRDIKSD 406 Query: 248 NILLDNSFHVKVADFGLSRLFPLEVTHVSTVPQGTPGYVDPVYHQCYKLTDKSDVSTSGV 69 NILL VK+ DFG E + ST+ GTP ++ P K D+ + G+ Sbjct: 407 NILLGMDGSVKLTDFGFCAQITPEQSKRSTM-VGTPYWMAPEVVTRKAYGPKVDIWSLGI 465 Query: 68 VLVELISSKP 39 + +E++ +P Sbjct: 466 MAIEMVEGEP 475 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 72,481,583 Number of Sequences: 219361 Number of extensions: 1562136 Number of successful extensions: 6487 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5877 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6096 length of database: 80,573,946 effective HSP length: 102 effective length of database: 58,199,124 effective search space used: 3026354448 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
