>CTNS_ARATH (P57758) Cystinosin homolog|
          Length = 270

 Score =  209 bits (533), Expect = 4e-54
 Identities = 91/141 (64%), Positives = 118/141 (83%)
 Frame = +3

Query: 159 SSWNSVGLGVLYQVIGWVAFFAWSFSFYPQVVLNYRRKSVVGLNFDFLVLNFTKHSSHLI 338
           +SWNS+ L + Y+++GW+AF +WS SFYPQ++LN+RR+SVVGLNFDF++LN TKHSS++I
Sbjct: 2   ASWNSIPLEISYEIVGWIAFASWSISFYPQLILNFRRRSVVGLNFDFVMLNLTKHSSYMI 61

Query: 339 YNAALFFSPFIQKQYHDKFGDKEMIPVAANDVAFSLHAVALTSFTLYQVFIYERGQQKVS 518
           YN  L+FSP IQKQY D +GDKEMIPVAANDVAFS+HAV +T+ TL+Q+FIYERG QKVS
Sbjct: 62  YNVCLYFSPVIQKQYFDTYGDKEMIPVAANDVAFSIHAVVMTAVTLFQIFIYERGPQKVS 121

Query: 519 KVCISITAVVWSAAIVCLIVA 581
           ++ I I  VVW  A +C  +A
Sbjct: 122 RLAIGIVVVVWGFAAICFFIA 142



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 13/43 (30%), Positives = 22/43 (51%)
 Frame = +3

Query: 189 LYQVIGWVAFFAWSFSFYPQVVLNYRRKSVVGLNFDFLVLNFT 317
           L  +   +  F     + PQ  +N+ RKS VG +   ++L+FT
Sbjct: 151 LISIFNSIQVFMTCVKYIPQAKMNFTRKSTVGWSIGNILLDFT 193

>CTNS_HUMAN (O60931) Cystinosin|
          Length = 367

 Score =  129 bits (325), Expect = 5e-30
 Identities = 64/137 (46%), Positives = 91/137 (66%)
 Frame = +3

Query: 171 SVGLGVLYQVIGWVAFFAWSFSFYPQVVLNYRRKSVVGLNFDFLVLNFTKHSSHLIYNAA 350
           S  + ++ QVIGW+ F AWS SFYPQV++N+RRKSV+GL+FDF+ LN T   ++ ++N  
Sbjct: 120 SSAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIG 179

Query: 351 LFFSPFIQKQYHDKFGDKEMIPVAANDVAFSLHAVALTSFTLYQVFIYERGQQKVSKVCI 530
           L + P+I++Q+  K+    + PV +NDV FSLHAV LT   + Q  +YERG Q+VS   I
Sbjct: 180 LLWVPYIKEQFLLKY-PNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAI 238

Query: 531 SITAVVWSAAIVCLIVA 581
               + W  A V +IVA
Sbjct: 239 GFLVLAWLFAFVTMIVA 255



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 26/104 (25%), Positives = 46/104 (44%), Gaps = 9/104 (8%)
 Frame = +3

Query: 198 VIGWVAF-FAWSF--------SFYPQVVLNYRRKSVVGLNFDFLVLNFTKHSSHLIYNAA 350
           VI W+ F F +S+         ++PQ  +N+  KS  G +   ++L+FT  S  L+    
Sbjct: 259 VITWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLL---Q 315

Query: 351 LFFSPFIQKQYHDKFGDKEMIPVAANDVAFSLHAVALTSFTLYQ 482
           +F   +   Q+   FGD     +    + F +    +  F LY+
Sbjct: 316 MFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDV-VFFIQHFCLYR 358

>CTNS_MOUSE (P57757) Cystinosin|
          Length = 367

 Score =  128 bits (322), Expect = 1e-29
 Identities = 63/134 (47%), Positives = 89/134 (66%)
 Frame = +3

Query: 180 LGVLYQVIGWVAFFAWSFSFYPQVVLNYRRKSVVGLNFDFLVLNFTKHSSHLIYNAALFF 359
           + ++ QVIGW+ F AWS SFYPQV+ N+RRKSV+GL+FDFL LN T   ++ ++N  L +
Sbjct: 123 VSIINQVIGWIYFMAWSVSFYPQVIQNWRRKSVIGLSFDFLALNLTGFVAYSVFNIGLLW 182

Query: 360 SPFIQKQYHDKFGDKEMIPVAANDVAFSLHAVALTSFTLYQVFIYERGQQKVSKVCISIT 539
            P+IQ+++  K+    + PV +ND  FSLHAVALT   + Q  +YERG Q+VS   I   
Sbjct: 183 VPYIQEEFLLKY-PNGVNPVDSNDAFFSLHAVALTLIVILQCCLYERGNQRVSWPSIGFL 241

Query: 540 AVVWSAAIVCLIVA 581
            + W   +V +IVA
Sbjct: 242 VLAWLFVLVTMIVA 255



 Score = 29.3 bits (64), Expect = 8.6
 Identities = 30/129 (23%), Positives = 52/129 (40%), Gaps = 22/129 (17%)
 Frame = +3

Query: 162 SWNSVGLGVL-------------YQVIGWVAF-FAWSF--------SFYPQVVLNYRRKS 275
           SW S+G  VL               +  W+ F F +S+         ++PQ  +N+  KS
Sbjct: 234 SWPSIGFLVLAWLFVLVTMIVAAVGITTWLQFLFCFSYIKLIITLIKYFPQAYMNFYYKS 293

Query: 276 VVGLNFDFLVLNFTKHSSHLIYNAALFFSPFIQKQYHDKFGDKEMIPVAANDVAFSLHAV 455
             G +   ++L+FT  S  L+    +F   +   Q+   FGD     +    + F +   
Sbjct: 294 TKGWSIGGVLLDFTGGSFSLL---QMFLQSYNNDQWTLIFGDPTKFGLGVFTIFFDV-VF 349

Query: 456 ALTSFTLYQ 482
            +  F LY+
Sbjct: 350 FIQHFYLYR 358

>CTNS_CAEEL (Q09500) Cystinosin homolog|
          Length = 404

 Score =  114 bits (285), Expect = 2e-25
 Identities = 54/125 (43%), Positives = 78/125 (62%)
 Frame = +3

Query: 180 LGVLYQVIGWVAFFAWSFSFYPQVVLNYRRKSVVGLNFDFLVLNFTKHSSHLIYNAALFF 359
           L +L Q++GW  FFAWS SFYPQ+ LN++RKSVVGLNFDFL LN     ++ I+N  +++
Sbjct: 125 LAILIQIVGWTYFFAWSISFYPQMYLNFKRKSVVGLNFDFLSLNLVGFCAYAIFNLLMYY 184

Query: 360 SPFIQKQYHDKFGDKEMIPVAANDVAFSLHAVALTSFTLYQVFIYERGQQKVSKVCISIT 539
           +  ++ +Y +    +   PV  NDV F++HA      T+ Q   YER  Q VS  CI++ 
Sbjct: 185 NSHVKNEY-NIVNPRSPPPVLLNDVVFAVHAFLACFITILQCLFYERDNQSVSSKCIALM 243

Query: 540 AVVWS 554
            V+ S
Sbjct: 244 IVLIS 248



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 12/27 (44%), Positives = 18/27 (66%)
 Frame = +3

Query: 237 FYPQVVLNYRRKSVVGLNFDFLVLNFT 317
           ++PQ   NY RKS VG +   ++L+FT
Sbjct: 283 YFPQAYFNYTRKSTVGWSIGNIMLDFT 309

>CTNS_DROME (Q9VCR7) Cystinosin homolog|
          Length = 397

 Score =  112 bits (279), Expect = 1e-24
 Identities = 56/123 (45%), Positives = 75/123 (60%)
 Frame = +3

Query: 198 VIGWVAFFAWSFSFYPQVVLNYRRKSVVGLNFDFLVLNFTKHSSHLIYNAALFFSPFIQK 377
           + GWV F AWS SFYPQ+  NYRRKSV GLNFDFL LN    + + ++N  L+F   +Q 
Sbjct: 134 IFGWVYFVAWSVSFYPQIWSNYRRKSVEGLNFDFLALNIVGFTLYSMFNCGLYFIEDLQN 193

Query: 378 QYHDKFGDKEMIPVAANDVAFSLHAVALTSFTLYQVFIYERGQQKVSKVCISITAVVWSA 557
           +Y  ++    + PV  NDV FSLHA+  T  T+ Q F Y+R QQ+VS +   I A+    
Sbjct: 194 EYEVRY-PLGVNPVMLNDVVFSLHAMFATCITILQCFFYQRAQQRVSFIAYGILAIFAVV 252

Query: 558 AIV 566
            +V
Sbjct: 253 VVV 255



 Score = 31.2 bits (69), Expect = 2.3
 Identities = 27/125 (21%), Positives = 48/125 (38%), Gaps = 9/125 (7%)
 Frame = +3

Query: 198 VIGWVAFFAWS---------FSFYPQVVLNYRRKSVVGLNFDFLVLNFTKHSSHLIYNAA 350
           VI W+ F  +            + PQ ++NYRRKS  G +   ++L+FT  +  ++    
Sbjct: 264 VIHWLDFLYYCSYVKLTITIIKYVPQALMNYRRKSTSGWSIGNILLDFTGGTLSML---Q 320

Query: 351 LFFSPFIQKQYHDKFGDKEMIPVAANDVAFSLHAVALTSFTLYQVFIYERGQQKVSKVCI 530
           +  +      +   FGD     +    V F +       F L     Y   ++  S    
Sbjct: 321 MILNAHNYDDWVSIFGDPTKFGLGLFSVLFDVF------FMLQHYVFYRHSRESSSSDLT 374

Query: 531 SITAV 545
           ++T V
Sbjct: 375 TVTDV 379

>ERS1_YEAST (P17261) Transmembrane protein ERS1 (ERD suppressor)|
          Length = 260

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 28/99 (28%), Positives = 47/99 (47%)
 Frame = +3

Query: 189 LYQVIGWVAFFAWSFSFYPQVVLNYRRKSVVGLNFDFLVLNFTKHSSHLIYNAALFFSPF 368
           L  ++G V   +WS S YP ++ N+R KS   ++ DF++LN   +S  +I   ++F   +
Sbjct: 4   LDDILGIVYVTSWSISMYPPIITNWRHKSASAISMDFVMLNTAGYSYLVI---SIFLQLY 60

Query: 369 IQKQYHDKFGDKEMIPVAANDVAFSLHAVALTSFTLYQV 485
             K   D+  D     +   D  + LH   +    L QV
Sbjct: 61  CWKMTGDE-SDLGRPKLTQFDFWYCLHGCLMNVVLLTQV 98

>YBZ7_YEAST (P38279) Hypothetical 33.5 kDa protein in MRPS9-YSW1 intergenic|
           region
          Length = 296

 Score = 35.4 bits (80), Expect = 0.12
 Identities = 16/48 (33%), Positives = 31/48 (64%)
 Frame = +3

Query: 195 QVIGWVAFFAWSFSFYPQVVLNYRRKSVVGLNFDFLVLNFTKHSSHLI 338
           Q++G+++   +  S  PQ+VLN++RKS  G++F F +     ++S +I
Sbjct: 209 QILGYLSAILYLGSRIPQIVLNFKRKSCEGVSFLFFLFACLGNTSFII 256



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 14/35 (40%), Positives = 21/35 (60%)
 Frame = +3

Query: 204 GWVAFFAWSFSFYPQVVLNYRRKSVVGLNFDFLVL 308
           G ++   W   F PQ+  N+RR+S  GL+  F+VL
Sbjct: 18  GSISICCWIVVFVPQIYENFRRQSAEGLSLLFIVL 52

>YO092_YEAST (Q12010) Uncharacterized protein YOL092W|
          Length = 308

 Score = 35.4 bits (80), Expect = 0.12
 Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
 Frame = +3

Query: 135 TPPPPAMSSSWNSVGLGV--LYQVIGWVAFFAWSFSFYPQVVLNYRRKSVVGLNFDFLV 305
           T PPP    S     L +  + Q+ G+++   +  S  PQ++LN++RKS  G++F F +
Sbjct: 191 TQPPPVEDPSLPVPELQINWMAQIFGYLSALLYLGSRIPQILLNFKRKSCEGISFLFFL 249



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 14/37 (37%), Positives = 21/37 (56%)
 Frame = +3

Query: 198 VIGWVAFFAWSFSFYPQVVLNYRRKSVVGLNFDFLVL 308
           + G ++   W   F PQ+  N+ RKS  GL+  F+VL
Sbjct: 16  ISGSISISCWIIVFVPQIYENFYRKSSDGLSLLFVVL 52

>KR73_ICHV1 (Q00094) Gene 73 protein kinase (EC 2.7.11.1)|
          Length = 962

 Score = 30.0 bits (66), Expect = 5.0
 Identities = 11/32 (34%), Positives = 21/32 (65%)
 Frame = -3

Query: 341 VYEVGRVLCEIQHQKIEVQTHDTLAPVVEDDL 246
           VY+VG + C++QH ++     + ++ VVE+ L
Sbjct: 315 VYKVGNLACKVQHGRVMPGVSNAISDVVEESL 346

>Y1778_OCEIH (Q8EQC3) UPF0302 protein OB1778|
          Length = 184

 Score = 30.0 bits (66), Expect = 5.0
 Identities = 14/37 (37%), Positives = 21/37 (56%)
 Frame = +3

Query: 297 FLVLNFTKHSSHLIYNAALFFSPFIQKQYHDKFGDKE 407
           ++ LNF K + H  Y + L  +PFI + Y+    DKE
Sbjct: 98  YVQLNFRKSNQHSYYASVLEENPFIPEDYYLTTDDKE 134

>RIMM_BUCAP (Q8K9F5) 16S rRNA-processing protein rimM|
          Length = 175

 Score = 29.6 bits (65), Expect = 6.6
 Identities = 21/90 (23%), Positives = 43/90 (47%), Gaps = 6/90 (6%)
 Frame = +3

Query: 180 LGVLYQVIGWVAFFAWS------FSFYPQVVLNYRRKSVVGLNFDFLVLNFTKHSSHLIY 341
           +G  Y ++GWV FF+++      FS++P  +L  + + +    +     NF  H  +++ 
Sbjct: 17  IGKAYGILGWVKFFSFTENKEKIFSYFPWFILKKKWEIIHVDKWKKHNNNFIIHIENILD 76

Query: 342 NAALFFSPFIQKQYHDKFGDKEMIPVAAND 431
            + +  S F   +    F DK ++P+   D
Sbjct: 77  RSTV--SKFTNLEI---FIDKSILPILKED 101

>MDR_PLAFF (P13568) Multidrug resistance protein (EC 3.6.3.44) (Chloroquine|
           resistance protein)
          Length = 1419

 Score = 29.6 bits (65), Expect = 6.6
 Identities = 18/56 (32%), Positives = 29/56 (51%), Gaps = 1/56 (1%)
 Frame = +3

Query: 240 YPQVVLNYRRKSVVGLNFDFLVLNFTKHSSHLIYNA-ALFFSPFIQKQYHDKFGDK 404
           YP   L Y R      +F  L  N  K+S +++  A A+F S  ++  Y++K G+K
Sbjct: 803 YPVFALLYARYVSTLFDFANLEYNSNKYSIYILLIAIAMFISETLKNYYNNKIGEK 858

>YD03_SCHPO (Q10227) Hypothetical protein C2E12.03c in chromosome I|
          Length = 283

 Score = 29.3 bits (64), Expect = 8.6
 Identities = 13/39 (33%), Positives = 22/39 (56%)
 Frame = +3

Query: 189 LYQVIGWVAFFAWSFSFYPQVVLNYRRKSVVGLNFDFLV 305
           ++ ++G V    W     PQ++ NYR KS  GL+  F++
Sbjct: 21  VFAILGTVC---WCVQLIPQIIKNYRAKSTEGLDTLFIL 56


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,055,277
Number of Sequences: 219361
Number of extensions: 1345566
Number of successful extensions: 3508
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 3404
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3504
length of database: 80,573,946
effective HSP length: 106
effective length of database: 57,321,680
effective search space used: 4986986160
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)