ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bart21h03 |
|---|---|
| Clone Library Name | barley_pub |
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 223 bits (568), Expect = 3e-58 Identities = 110/169 (65%), Positives = 134/169 (79%), Gaps = 2/169 (1%) Frame = +2 Query: 86 AISTDSRSEEKPSQHSQEEKR--WVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVL 259 A DS E+ Q +++ K+ W L DFD+G+ LG+GKFG+VYLARE++S I+ALKVL Sbjct: 96 ASGNDSEKEQASLQKTEDTKKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVL 155 Query: 260 FKSQLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQR 439 FK+QL+++ VEHQLRREVEIQSHLRHPNILRLYGYF+D TRVYLILE+A G +Y+ELQ+ Sbjct: 156 FKTQLEKANVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK 215 Query: 440 CKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 F E+R+ATYI LA AL Y H K VIHRDIKPENLL+G GELKIA Sbjct: 216 LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIA 264
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 222 bits (565), Expect = 7e-58 Identities = 107/165 (64%), Positives = 132/165 (80%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 STD + ++K+W L DF++G+ LG+GKFG+VYLARE+ S I+ALKVLFKSQ Sbjct: 116 STDQGKTSAVPKEEGKKKQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQ 175 Query: 272 LKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHF 451 L+++ VEHQLRREVEIQSHLRHPNILRLYGYF+D +RVYLIL++A GEL++ELQ+C F Sbjct: 176 LEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRF 235 Query: 452 SERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 ++RSA YI LA AL+Y H K VIHRDIKPENLL+G GELKIA Sbjct: 236 DDQRSAMYIKQLAEALLYCHSKKVIHRDIKPENLLLGSNGELKIA 280
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 221 bits (562), Expect = 2e-57 Identities = 110/169 (65%), Positives = 133/169 (78%), Gaps = 2/169 (1%) Frame = +2 Query: 86 AISTDSRSEEKPSQHSQEEKR--WVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVL 259 A +S E+ Q +++ K+ W L DFD+G+ LG+GKFG+VYLAREK+S I+ALKVL Sbjct: 98 ASGNNSEKEQTSIQKTEDSKKRQWTLEDFDIGRPLGKGKFGNVYLAREKQSKFILALKVL 157 Query: 260 FKSQLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQR 439 FK QL+++ VEHQLRREVEIQSHLRHPNILRLYGYF+D TRVYLILE+A G +Y+ELQ+ Sbjct: 158 FKVQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK 217 Query: 440 CKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 F E+R+ATYI LA AL Y H K VIHRDIKPENLL+G GELKIA Sbjct: 218 LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIA 266
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 221 bits (562), Expect = 2e-57 Identities = 107/165 (64%), Positives = 132/165 (80%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 STD + ++K+W L DF++G+ LG+GKFG+VYLARE+ S I+ALKVLFKSQ Sbjct: 116 STDQGKTLAVPKEEGKKKQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQ 175 Query: 272 LKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHF 451 L+++ VEHQLRREVEIQSHLRHPNILRLYGYF+D +RVYLIL++A GEL++ELQ+C F Sbjct: 176 LEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRF 235 Query: 452 SERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 ++RSA YI LA AL+Y H K VIHRDIKPENLL+G GELKIA Sbjct: 236 DDQRSALYIKQLAEALLYCHSKKVIHRDIKPENLLLGSNGELKIA 280
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 219 bits (558), Expect = 5e-57 Identities = 109/162 (67%), Positives = 131/162 (80%), Gaps = 3/162 (1%) Frame = +2 Query: 110 EEKPSQHSQEE---KRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQ 280 EE S+ EE ++W L DF++G+ LG+GKFG+VYLAREK+S I+ALKVLFK+QL++ Sbjct: 112 EELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEK 171 Query: 281 SQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSER 460 + VEHQLRREVEIQSHLRHPNILRLYGYF+D TRVYLILE+A G +Y+ELQ+ F E+ Sbjct: 172 AGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQ 231 Query: 461 RSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 R+ATYI LA AL Y H K VIHRDIKPENLL+G GELKIA Sbjct: 232 RTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIA 273
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 213 bits (542), Expect = 3e-55 Identities = 101/155 (65%), Positives = 131/155 (84%) Frame = +2 Query: 122 SQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQL 301 SQ SQ ++ + + +F++G+ LG+GKFG+VYLAREK+S IVALK+LFKSQ+++ VEHQL Sbjct: 68 SQGSQNKQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQL 127 Query: 302 RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIA 481 RRE+EIQ+HL+HPNIL+LY YFYDQ R+YLILE+A +GELYKELQ+ + F E+R+AT + Sbjct: 128 RREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSRTFDEQRTATIME 187 Query: 482 SLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 L+ AL Y H K VIHRDIKPENLL+G+QGELKIA Sbjct: 188 ELSDALTYCHKKKVIHRDIKPENLLLGLQGELKIA 222
>AURKB_HUMAN (Q96GD4) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1) (Aurora-B) Length = 344 Score = 211 bits (536), Expect = 2e-54 Identities = 100/148 (67%), Positives = 126/148 (85%) Frame = +2 Query: 143 KRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQ 322 + + + DF++G+ LG+GKFG+VYLAREK+S IVALKVLFKSQ+++ VEHQLRRE+EIQ Sbjct: 70 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 129 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 +HL HPNILRLY YFYD+ R+YLILE+A +GELYKELQ+ F E+R+AT + LA AL+ Sbjct: 130 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKIA 586 Y HGK VIHRDIKPENLL+G++GELKIA Sbjct: 190 YCHGKKVIHRDIKPENLLLGLKGELKIA 217
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 210 bits (535), Expect = 2e-54 Identities = 100/154 (64%), Positives = 129/154 (83%) Frame = +2 Query: 125 QHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLR 304 Q SQ + + + +F++G+ LG+GKFG+VYLAREK+S IVALK+LFKSQ+++ VEHQLR Sbjct: 67 QGSQSRQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLR 126 Query: 305 REVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIAS 484 RE+EIQ+HL+HPNIL+LY YFYDQ R+YLILE+A +GELYKELQ+ F E+R+AT + Sbjct: 127 REIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSGTFDEQRTATIMEE 186 Query: 485 LARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 L+ AL+Y H K VIHRDIKPENLL+G+QGELKIA Sbjct: 187 LSDALMYCHKKKVIHRDIKPENLLLGLQGELKIA 220
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 203 bits (516), Expect = 3e-52 Identities = 101/166 (60%), Positives = 132/166 (79%) Frame = +2 Query: 89 ISTDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKS 268 ++T +++ ++PS S +R + DF++G+ LG+GKFG+VYLAR K S IVALKVLFKS Sbjct: 20 LATANQTAQQPS--SPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKS 77 Query: 269 QLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH 448 Q+++ +EHQLRRE+EIQ+HL+HPNILRLY YF+D RVYLILE+A +GELYKELQ+ + Sbjct: 78 QIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK 137 Query: 449 FSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 E+R+AT I LA AL Y H K VIHRDIKPENLL+G +GE+KIA Sbjct: 138 LDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIA 183
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 196 bits (497), Expect = 5e-50 Identities = 95/148 (64%), Positives = 120/148 (81%) Frame = +2 Query: 143 KRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQ 322 K + ++DF++G+ LGRGKFG VYLAR K + IVALKVLFKS++++ +EHQLRREVEIQ Sbjct: 9 KHFTINDFEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQ 68 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 +HL+H NILRLY YFYD TR+YLILE+A GELYKELQR + ++R+AT I L+ AL Sbjct: 69 AHLQHRNILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDALT 128 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKIA 586 Y H K VIHRDIKPENLL+G+ GE+KI+ Sbjct: 129 YCHEKKVIHRDIKPENLLLGLNGEVKIS 156
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 193 bits (491), Expect = 3e-49 Identities = 91/156 (58%), Positives = 123/156 (78%) Frame = +2 Query: 119 PSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQ 298 PS + + + + F++GK LG+GKFG VYLA+EK++ IVALK L KS+L QS++E Q Sbjct: 74 PSSAGPQWREFHIGMFEIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQ 133 Query: 299 LRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYI 478 +RRE+EIQS+LRH NILRLYG+F+D+ R+YLILE A +GELY+ L+R K FSE ++ YI Sbjct: 134 VRREIEIQSNLRHKNILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKRFSEEVASKYI 193 Query: 479 ASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 +A AL YLH KHVIHRDIKPEN+L+G+ GE+K++ Sbjct: 194 FQMANALSYLHKKHVIHRDIKPENILLGIDGEIKLS 229
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 171 bits (433), Expect = 1e-42 Identities = 79/148 (53%), Positives = 113/148 (76%) Frame = +2 Query: 143 KRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQ 322 + + L DF++GKALG+GKFG VYL ++K++ + ALK + K +L + VE Q RREVEIQ Sbjct: 92 RNYSLDDFEIGKALGKGKFGKVYLVKDKKTGFVSALKCMEKKELVEGNVEKQFRREVEIQ 151 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 S+LRH N+LRL+G+F+D+ RVYLILE+ GELYK L+ K F+E +++YI ++ AL+ Sbjct: 152 SNLRHTNVLRLFGHFHDKDRVYLILEYVVHGELYKLLRNQKRFTESTASSYIYQMSEALL 211 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKIA 586 YLHGK++IHRDIKPEN+L+ +KI+ Sbjct: 212 YLHGKNIIHRDIKPENILLHFNDTIKIS 239
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 157 bits (397), Expect = 2e-38 Identities = 70/143 (48%), Positives = 102/143 (71%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 L+DF++GK LG+GKFG VY R S + ALK + K + Q +E Q RREVEIQS LR Sbjct: 106 LADFEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQFRREVEIQSSLR 165 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPN+ +LYGYF+D+ RVYL++E+ GELYK L+ HF++ ++ Y+ +A AL Y+H Sbjct: 166 HPNLTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRSHFNDVVASYYVYQMADALDYMHE 225 Query: 515 KHVIHRDIKPENLLVGVQGELKI 583 ++++HRDIKPEN+++G +K+ Sbjct: 226 RNILHRDIKPENIIIGFNNTIKL 248
>IPL1_DEBHA (Q6BVA0) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 412 Score = 152 bits (383), Expect = 9e-37 Identities = 73/148 (49%), Positives = 100/148 (67%) Frame = +2 Query: 143 KRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQ 322 + L DF++GK LG+GK G VY + K S +I ALKV+ K L ++E RRE+EIQ Sbjct: 141 RHMTLDDFEIGKVLGKGKLGKVYCVKHKTSGYIAALKVMAKKDLIDLKLEKNFRREIEIQ 200 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 S+L HP I RLYG+FYD VYLILE++ GELY L+ + F++ ++ YI +A AL Sbjct: 201 SNLIHPKISRLYGFFYDHKNVYLILEYSIHGELYHHLKVQRRFNDATASHYIYQVALALD 260 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKIA 586 YLH KH+IHRDIKPEN+L+ +K++ Sbjct: 261 YLHTKHIIHRDIKPENILLSTDNCIKLS 288
>IPL1_CANAL (Q59S66) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 530 Score = 151 bits (381), Expect = 2e-36 Identities = 72/165 (43%), Positives = 110/165 (66%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 S+ S + KP Q + L DF+ GK LG+GK G VY + K+S I ALKV+ KS+ Sbjct: 226 SSSSHTSPKPQQ------QLTLDDFEFGKILGKGKLGRVYCVKHKQSGLIFALKVMSKSE 279 Query: 272 LKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHF 451 + ++E LRRE+EIQS+L H NI RLY +F+D +YL+LE++ +GELY L++ K F Sbjct: 280 IMNLKLEKSLRREIEIQSNLYHINITRLYSWFHDSINIYLLLEYSIEGELYTHLKKLKRF 339 Query: 452 SERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 ++ YI + +ALI+LH + +IHRD+KPEN+++ + +LK++ Sbjct: 340 DNIMASNYIFQITQALIFLHQRGIIHRDLKPENIMISLDNQLKLS 384
>IPL1_CANGA (Q6FV07) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 358 Score = 150 bits (379), Expect = 3e-36 Identities = 70/144 (48%), Positives = 103/144 (71%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 L DF+VG+ LG+GKFG VY R K+S I ALK + K+++ Q + QL+REV+IQ + Sbjct: 97 LKDFEVGRKLGKGKFGKVYCVRHKKSGFICALKAIEKNEILQFNLLKQLKREVDIQLGMD 156 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI++LY +F+D+ RVYL++EH+ GELYK L+ F++ ++ YI +A AL Y+H Sbjct: 157 HPNIIKLYAHFHDEKRVYLLMEHSINGELYKSLKNNGPFNDVLASHYIYQIADALHYMHK 216 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 K +IHRD+KPEN+L+G +K+A Sbjct: 217 KRIIHRDVKPENVLIGFDNVVKLA 240
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 149 bits (375), Expect = 8e-36 Identities = 68/143 (47%), Positives = 102/143 (71%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 L DF++GK LG+GKFG VY R + + +I ALKV+ K ++ + ++ Q RREVEIQ+ L Sbjct: 101 LDDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLN 160 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPN+ + YGYF+D+ RVYL++E+ GE+YK L+ F++ ++ YI +A AL Y+H Sbjct: 161 HPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYMHK 220 Query: 515 KHVIHRDIKPENLLVGVQGELKI 583 K++IHRDIKPEN+L+G +K+ Sbjct: 221 KNIIHRDIKPENILIGFNNVIKL 243
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 147 bits (370), Expect = 3e-35 Identities = 65/154 (42%), Positives = 103/154 (66%) Frame = +2 Query: 122 SQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQL 301 + H+ + + L DF++GK LG+GKFG VY + + + I ALK + K ++ Q ++ Q Sbjct: 86 NDHNDKFENMTLQDFEIGKILGKGKFGKVYCVKHRETGLICALKAMEKKEIVQYTIQKQF 145 Query: 302 RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIA 481 RREVEIQ +H N+ +LYG+FYD+ RVYL++E+ GELYK L+ +E ++ ++ Sbjct: 146 RREVEIQGSFKHKNLTQLYGFFYDEKRVYLLMEYVYYGELYKFLKNNGPLNETLASYFVY 205 Query: 482 SLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 +A AL Y+H K+++HRDIKPEN+L+G +K+ Sbjct: 206 QMANALDYMHSKNILHRDIKPENILIGFNNTIKL 239
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 108 bits (269), Expect = 1e-23 Identities = 58/158 (36%), Positives = 88/158 (55%) Frame = +2 Query: 110 EEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQV 289 ++ P+Q + ++ DF GK LG G F V LARE +S A+K+L K + + Sbjct: 67 QQHPAQLPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENK 126 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 + RE ++ S L HP ++LY F D ++Y L +A GEL K +++ F E + Sbjct: 127 VPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTR 186 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y A + AL YLHGK +IHRD+KPEN+L+ ++I Sbjct: 187 FYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQI 224
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 108 bits (269), Expect = 1e-23 Identities = 58/158 (36%), Positives = 88/158 (55%) Frame = +2 Query: 110 EEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQV 289 ++ P+Q + ++ DF GK LG G F V LARE +S A+K+L K + + Sbjct: 67 QQHPAQLPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENK 126 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 + RE ++ S L HP ++LY F D ++Y L +A GEL K +++ F E + Sbjct: 127 VPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTR 186 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y A + AL YLHGK +IHRD+KPEN+L+ ++I Sbjct: 187 FYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQI 224
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 108 bits (269), Expect = 1e-23 Identities = 51/141 (36%), Positives = 82/141 (58%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 ++VG+ +G G F V AR + VA+K++ KS + ++++ Q++RE+ I +RHPN Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I+RLY +++Y++LE GEL+ + E S Y L A+ + H K V Sbjct: 71 IVRLYEVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKYFQQLVDAVAHCHCKGV 130 Query: 524 IHRDIKPENLLVGVQGELKIA 586 HRD+KPENLL+ G LK++ Sbjct: 131 YHRDLKPENLLLDTNGNLKVS 151
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 107 bits (267), Expect = 3e-23 Identities = 57/170 (33%), Positives = 98/170 (57%), Gaps = 1/170 (0%) Frame = +2 Query: 80 AMAISTDSRSEEKPSQHSQEEKRWVLSD-FDVGKALGRGKFGHVYLAREKRSSHIVALKV 256 A+A +T + KP + + L +++ + LG+G +G V A E+ S +VA+K Sbjct: 26 AVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKS 85 Query: 257 LFKSQLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQ 436 + K ++K Q +RRE+EI S L HP+I+ +Y F ++ ++ +I+E+A+KGELY + Sbjct: 86 IRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYIS 145 Query: 437 RCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + SER + + + A+ Y H V+HRD+K EN+L+ +KIA Sbjct: 146 ERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIA 195
>KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC 2.7.11.11) (PKA| 3) Length = 398 Score = 106 bits (265), Expect = 4e-23 Identities = 57/154 (37%), Positives = 89/154 (57%), Gaps = 1/154 (0%) Frame = +2 Query: 125 QHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQL 301 Q+ ++ LSDF + + LG G FG V+L R + ALK L K + K QVEH Sbjct: 75 QYRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHT- 133 Query: 302 RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIA 481 E + S + HP I+R++G F D +V++++++ GEL+ L++ + F + Y A Sbjct: 134 NDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAA 193 Query: 482 SLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 + AL YLH K +I+RD+KPEN+L+ G +KI Sbjct: 194 EVCLALEYLHSKDIIYRDLKPENILLDKNGHIKI 227
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 105 bits (263), Expect = 7e-23 Identities = 59/156 (37%), Positives = 87/156 (55%), Gaps = 3/156 (1%) Frame = +2 Query: 125 QHSQ---EEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEH 295 QH+Q + ++ DF GK LG G F V LARE +S A+K+L K + + Sbjct: 66 QHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVP 125 Query: 296 QLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATY 475 + RE ++ S L HP ++LY F D ++Y L +A GEL K +++ F E + Y Sbjct: 126 YVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFY 185 Query: 476 IASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 A + AL YLHGK +IHRD+KPEN+L+ ++I Sbjct: 186 TAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQI 221
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 105 bits (263), Expect = 7e-23 Identities = 53/141 (37%), Positives = 85/141 (60%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 ++VGK LG+G F VY AR ++ VA+KV+ K ++ + + Q++RE+ LRHPN Sbjct: 12 YEVGKFLGQGTFAKVYHARHLKTGDSVAIKVIDKERILKVGMTEQIKREISAMRLLRHPN 71 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I+ L+ ++++Y ++EH GEL+ ++ K E + Y L RA+ + H + V Sbjct: 72 IVELHEVMATKSKIYFVMEHVKGGELFNKVSTGK-LREDVARKYFQQLVRAVDFCHSRGV 130 Query: 524 IHRDIKPENLLVGVQGELKIA 586 HRD+KPENLL+ G LKI+ Sbjct: 131 CHRDLKPENLLLDEHGNLKIS 151
>KAPC_DICDI (P34099) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) Length = 648 Score = 105 bits (262), Expect = 1e-22 Identities = 57/144 (39%), Positives = 86/144 (59%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQ-SQVEHQLRREVEIQSHL 331 L +F + LG G FG VYL + + A+K L K+ + Q QVEH L E I S + Sbjct: 333 LKEFKQIRVLGTGTFGKVYLIQNTKDGCYYAMKCLNKAYVVQLKQVEH-LNSEKSILSSI 391 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 HP I+ LY F D+ ++YL+ E+ A GE++ L++ FS + Y A + AL +LH Sbjct: 392 HHPFIVNLYQAFQDEKKLYLLFEYVAGGEVFTHLRKSMKFSNSTAKFYAAEIVLALEFLH 451 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 +++++RD+KPENLL+ QG +KI Sbjct: 452 KQNIVYRDLKPENLLIDNQGHIKI 475
>PRKY_HUMAN (O43930) Serine/threonine-protein kinase PRKY (EC 2.7.11.1)| Length = 277 Score = 105 bits (261), Expect = 1e-22 Identities = 50/155 (32%), Positives = 86/155 (55%) Frame = +2 Query: 119 PSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQ 298 P S E + L D D +G G FG V+L +EK + H ALKV+ + + + E Sbjct: 34 PEARSPEAPAYRLQDCDALVTMGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRRKQEQH 93 Query: 299 LRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYI 478 + E + + HP ++RL+ ++++ +Y+++E+ GEL+ L+ HFS Y Sbjct: 94 VHNEKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPGGELFSYLRNRGHFSSTTGLFYS 153 Query: 479 ASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 A + A+ YLH K +++RD+KPEN+L+ G +K+ Sbjct: 154 AEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKL 188
>PRKX_HUMAN (P51817) Serine/threonine-protein kinase PRKX (EC 2.7.11.1)| (Protein kinase PKX1) Length = 358 Score = 104 bits (260), Expect = 2e-22 Identities = 51/155 (32%), Positives = 86/155 (55%) Frame = +2 Query: 119 PSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQ 298 P S E + L DFD +G G FG V+L +EK + H ALKV+ + + + E Sbjct: 34 PEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQH 93 Query: 299 LRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYI 478 + E + + HP ++RL+ ++D+ +Y+++E+ GEL+ L+ FS Y Sbjct: 94 VHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYS 153 Query: 479 ASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 A + A+ YLH K +++RD+KPEN+L+ G +K+ Sbjct: 154 AEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKL 188
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 104 bits (259), Expect = 2e-22 Identities = 50/141 (35%), Positives = 86/141 (60%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 +++ + LG+G +G V A E+ S +VA+K + K ++K +RRE+EI S L HP+ Sbjct: 56 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPH 115 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I+ +Y F ++ ++ +I+E+A+KGELY + + SER + + + A+ Y H V Sbjct: 116 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 175 Query: 524 IHRDIKPENLLVGVQGELKIA 586 +HRD+K EN+L+ +KIA Sbjct: 176 VHRDLKLENILLDDNCNIKIA 196
>KDC2_DROME (P16912) Protein kinase DC2 (EC 2.7.11.1)| Length = 583 Score = 104 bits (259), Expect = 2e-22 Identities = 57/164 (34%), Positives = 94/164 (57%), Gaps = 2/164 (1%) Frame = +2 Query: 98 DSRSEEKPS-QHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ- 271 D SEE S Q ++ +++ L D+ + K +G G FG V L R++ S A+K+L ++ Sbjct: 251 DDESEESSSVQTAKGVRKYHLDDYQIIKTVGTGTFGRVCLCRDRISEKYCAMKILAMTEV 310 Query: 272 LKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHF 451 ++ Q+EH ++ E I +RHP ++ L D + +Y+I ++ GEL+ L+ F Sbjct: 311 IRLKQIEH-VKNERNILREIRHPFVISLEWSTKDDSNLYMIFDYVCGGELFTYLRNAGKF 369 Query: 452 SERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 + + S Y A + AL YLH +++RD+KPENLL+ G LKI Sbjct: 370 TSQTSNFYAAEIVSALEYLHSLQIVYRDLKPENLLINRDGHLKI 413
>KAPB_SCHPO (P40376) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) Length = 512 Score = 103 bits (258), Expect = 3e-22 Identities = 58/161 (36%), Positives = 94/161 (58%), Gaps = 1/161 (0%) Frame = +2 Query: 104 RSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQ 280 R +P+ H+ ++ R+ + DF+ + LG G FG V+L + + A+KVL K ++ Sbjct: 182 RRRIRPADHTTKD-RYGIQDFNFLQTLGTGSFGRVHLVQSNHNRLYYAIKVLEKKKIVDM 240 Query: 281 SQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSER 460 Q+EH E I S ++HP I L+G F D ++++++ A GEL+ L++C F E+ Sbjct: 241 KQIEHTCD-ERYILSRVQHPFITILWGTFQDAKNLFMVMDFAEGGELFSLLRKCHRFPEK 299 Query: 461 RSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 + Y A + AL YLH +++RD+KPENLL+ G LKI Sbjct: 300 VAKFYAAEVILALDYLHHNQIVYRDLKPENLLLDRFGHLKI 340
>KAPC_CAEEL (P21137) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 404 Score = 103 bits (258), Expect = 3e-22 Identities = 61/158 (38%), Positives = 91/158 (57%), Gaps = 1/158 (0%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQV 289 E P+Q++ L DFD K LG G FG V L + K+S + A+K+L K ++ K QV Sbjct: 69 ENPAQNTA-----CLDDFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQV 123 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 EH L + +Q+ + P ++ + F D + +Y++LE + GE++ L+R FSE S Sbjct: 124 EHTLNEKRILQA-IDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSR 182 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y A + A YLH +I+RD+KPENLL+ G LKI Sbjct: 183 FYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKI 220
>KIN10_ARATH (Q38997) SNF1-related protein kinase catalytic alpha subunit KIN10| (EC 2.7.11.1) (AKIN10) (AKIN alpha2) Length = 535 Score = 103 bits (257), Expect = 4e-22 Identities = 49/145 (33%), Positives = 84/145 (57%) Frame = +2 Query: 152 VLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 +L ++ +G+ LG G FG V +A + H VA+K+L + ++K ++E ++RRE++I Sbjct: 38 ILPNYKLGRTLGIGSFGRVKIAEHALTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLF 97 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 HP+I+RLY T +YL++E+ GEL+ + E + + + + Y H Sbjct: 98 MHPHIIRLYEVIETPTDIYLVMEYVNSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCH 157 Query: 512 GKHVIHRDIKPENLLVGVQGELKIA 586 V+HRD+KPENLL+ + +KIA Sbjct: 158 RNMVVHRDLKPENLLLDSKCNVKIA 182
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 103 bits (257), Expect = 4e-22 Identities = 53/160 (33%), Positives = 91/160 (56%), Gaps = 1/160 (0%) Frame = +2 Query: 107 SEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQS 283 + + P + + ++ L DF + + LG G FG V+L R + A+KVL K Q+ K Sbjct: 51 TSQLPQKSLVSKGKYTLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMK 110 Query: 284 QVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERR 463 QVEH E + + HP ++R++G F D +++++++ GEL+ L++ + F Sbjct: 111 QVEHT-NDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPV 169 Query: 464 SATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 + Y A + AL YLH ++I+RD+KPEN+L+ G +KI Sbjct: 170 AKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKI 209
>AURKB_PIG (Q9N0X0) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-B) (Fragment) Length = 156 Score = 103 bits (257), Expect = 4e-22 Identities = 49/68 (72%), Positives = 59/68 (86%) Frame = +2 Query: 383 VYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVG 562 +YLILE+A +GELYKELQ+C+ F E+R+AT + LA ALIY HGK VIHRDIKPENLL+G Sbjct: 1 IYLILEYAPRGELYKELQKCRTFDEQRTATIMEELADALIYCHGKKVIHRDIKPENLLLG 60 Query: 563 VQGELKIA 586 +QGELKIA Sbjct: 61 LQGELKIA 68
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 103 bits (256), Expect = 5e-22 Identities = 51/128 (39%), Positives = 77/128 (60%) Frame = +2 Query: 176 KALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPNILRL 355 K LG+G FG V L+R+K + H A+KV+ K +K+ + L REVE+ L H NI++L Sbjct: 73 KILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKL 132 Query: 356 YGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVIHRD 535 Y +F D YL+ + GEL+ E+ K F E +A I + + Y+H +V+HRD Sbjct: 133 YEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRD 192 Query: 536 IKPENLLV 559 +KPEN+L+ Sbjct: 193 LKPENILL 200
>KAPCA_MOUSE (P05132) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 102 bits (255), Expect = 6e-22 Identities = 57/158 (36%), Positives = 92/158 (58%), Gaps = 1/158 (0%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQV 289 E PSQ++ + L FD K LG G FG V L + K S + A+K+L K ++ K Q+ Sbjct: 31 ETPSQNTAQ-----LDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQI 85 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 EH L + +Q+ + P +++L F D + +Y+++E+ A GE++ L+R FSE + Sbjct: 86 EHTLNEKRILQA-VNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHAR 144 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y A + YLH +I+RD+KPENLL+ QG +++ Sbjct: 145 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 182
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 102 bits (254), Expect = 8e-22 Identities = 52/145 (35%), Positives = 85/145 (58%), Gaps = 1/145 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + DF VG LG+G F VY A + VA+K++ K + ++ + +++ EV+I L+ Sbjct: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQ-RCKHFSERRSATYIASLARALIYLH 511 HP++L LY YF D VYL+LE GE+ + L+ R K FSER + ++ + ++YLH Sbjct: 69 HPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLH 128 Query: 512 GKHVIHRDIKPENLLVGVQGELKIA 586 ++HRD+ N+L+ +KIA Sbjct: 129 SHGILHRDLTLSNILLTRNMNIKIA 153
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 102 bits (253), Expect = 1e-21 Identities = 50/142 (35%), Positives = 85/142 (59%), Gaps = 1/142 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQ-VEHQLRREVEIQSHLRHP 340 +++GK LG G F V+ AR++R+ VA+K+L K +L + + + ++RE+ I L HP Sbjct: 21 YELGKLLGCGAFAKVFHARDRRTGQSVAVKILNKKKLLTNPALANNIKREISIMRRLSHP 80 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKH 520 NI++L+ +++++ +E GEL+ ++ + SE S Y L A+ Y H + Sbjct: 81 NIVKLHEVMATKSKIFFAMEFVKGGELFNKISKHGRLSEDLSRRYFQQLISAVGYCHARG 140 Query: 521 VIHRDIKPENLLVGVQGELKIA 586 V HRD+KPENLL+ G LK++ Sbjct: 141 VYHRDLKPENLLIDENGNLKVS 162
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 102 bits (253), Expect = 1e-21 Identities = 50/128 (39%), Positives = 78/128 (60%) Frame = +2 Query: 176 KALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPNILRL 355 K LG+G FG V L+++K + H A+KV+ K +K+ + L REVE+ L H NI++L Sbjct: 73 KILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLDHINIMKL 132 Query: 356 YGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVIHRD 535 Y +F D YL+ + + GEL+ E+ K F E +A I + + Y+H +V+HRD Sbjct: 133 YEFFEDNNYYYLVSDVYSGGELFDEIISRKRFYEVDAARIIKQVLSGITYMHKNNVVHRD 192 Query: 536 IKPENLLV 559 +KPEN+L+ Sbjct: 193 LKPENILL 200
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 102 bits (253), Expect = 1e-21 Identities = 50/128 (39%), Positives = 78/128 (60%) Frame = +2 Query: 176 KALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPNILRL 355 K LG+G FG V L+++K + H A+KV+ K +K+ + L REVE+ L H NI++L Sbjct: 73 KILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLDHINIMKL 132 Query: 356 YGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVIHRD 535 Y +F D YL+ + + GEL+ E+ K F E +A I + + Y+H +V+HRD Sbjct: 133 YEFFEDNNYYYLVSDVYSGGELFDEIISRKRFYEVDAARIIKQVLSGITYMHKNNVVHRD 192 Query: 536 IKPENLLV 559 +KPEN+L+ Sbjct: 193 LKPENILL 200
>KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC 2.7.11.11) (PKA| 1) (CDC25-suppressing protein kinase) (PK-25) Length = 397 Score = 102 bits (253), Expect = 1e-21 Identities = 53/147 (36%), Positives = 88/147 (59%), Gaps = 1/147 (0%) Frame = +2 Query: 146 RWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKS-QLKQSQVEHQLRREVEIQ 322 ++ L DF + + LG G FG V+L R + + A+KVL K ++ QVEH + + Sbjct: 81 KYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLML- 139 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 S + HP I+R++G F D ++++I+++ GEL+ L++ + F + Y A + AL Sbjct: 140 SIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALE 199 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKI 583 YLH K +I+RD+KPEN+L+ G +KI Sbjct: 200 YLHSKDIIYRDLKPENILLDKNGHIKI 226
>AKT3_RAT (Q63484) RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) Length = 454 Score = 101 bits (252), Expect = 1e-21 Identities = 60/163 (36%), Positives = 90/163 (55%), Gaps = 1/163 (0%) Frame = +2 Query: 98 DSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL- 274 D+ EE+ + KR ++DFD K LG+G FG V L REK S A+K+L K + Sbjct: 126 DNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVII 185 Query: 275 KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFS 454 + +V H L E + + RHP + L F + R+ ++E+ GEL+ L R + FS Sbjct: 186 AKDEVAHTLT-ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFS 244 Query: 455 ERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 E R+ Y A + AL YLH +++RD+K ENL++ G +KI Sbjct: 245 EDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKI 287
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 101 bits (252), Expect = 1e-21 Identities = 53/145 (36%), Positives = 84/145 (57%), Gaps = 1/145 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + DF VG LG+G F VY A + VA+K++ K + ++ + +++ EV+I L+ Sbjct: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQ-RCKHFSERRSATYIASLARALIYLH 511 HP+IL LY YF D VYL+LE GE+ + L+ R K FSE + ++ + ++YLH Sbjct: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128 Query: 512 GKHVIHRDIKPENLLVGVQGELKIA 586 ++HRD+ NLL+ +KIA Sbjct: 129 SHGILHRDLTLSNLLLTRNMNIKIA 153
>KPK19_ARATH (Q39030) Serine/threonine-protein kinase AtPK19 (EC 2.7.11.1)| (Ribosomal-protein S6 kinase homolog) Length = 471 Score = 101 bits (252), Expect = 1e-21 Identities = 56/163 (34%), Positives = 95/163 (58%), Gaps = 2/163 (1%) Frame = +2 Query: 101 SRSEEKPSQHSQEEKRWV--LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL 274 S +++ S+ S EE V + DF+V K +G+G FG VY R+K +S I A+KV+ K ++ Sbjct: 117 SGNDDTDSEKSPEEVSGVVGIEDFEVLKVVGQGAFGKVYQVRKKDTSEIYAMKVMRKDKI 176 Query: 275 KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFS 454 + ++ E +I + + HP I++L F + R+YL+L+ G L+ +L F Sbjct: 177 VEKNHAEYMKAERDILTKIDHPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFR 236 Query: 455 ERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 E + Y A + A+ +LH K ++HRD+KPEN+L+ V G + + Sbjct: 237 EDLARVYTAEIVSAVSHLHEKGIMHRDLKPENILMDVDGHVML 279
>AKT3_MOUSE (Q9WUA6) RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) Length = 479 Score = 101 bits (252), Expect = 1e-21 Identities = 60/163 (36%), Positives = 90/163 (55%), Gaps = 1/163 (0%) Frame = +2 Query: 98 DSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL- 274 D+ EE+ + KR ++DFD K LG+G FG V L REK S A+K+L K + Sbjct: 126 DNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVII 185 Query: 275 KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFS 454 + +V H L E + + RHP + L F + R+ ++E+ GEL+ L R + FS Sbjct: 186 AKDEVAHTLT-ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFS 244 Query: 455 ERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 E R+ Y A + AL YLH +++RD+K ENL++ G +KI Sbjct: 245 EDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKI 287
>AKT3_HUMAN (Q9Y243) RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2) Length = 479 Score = 101 bits (252), Expect = 1e-21 Identities = 60/163 (36%), Positives = 90/163 (55%), Gaps = 1/163 (0%) Frame = +2 Query: 98 DSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL- 274 D+ EE+ + KR ++DFD K LG+G FG V L REK S A+K+L K + Sbjct: 126 DNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVII 185 Query: 275 KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFS 454 + +V H L E + + RHP + L F + R+ ++E+ GEL+ L R + FS Sbjct: 186 AKDEVAHTLT-ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFS 244 Query: 455 ERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 E R+ Y A + AL YLH +++RD+K ENL++ G +KI Sbjct: 245 EDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKI 287
>KAPC_DROME (P12370) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 352 Score = 100 bits (250), Expect = 2e-21 Identities = 55/144 (38%), Positives = 86/144 (59%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 L DF+ K LG G FG V + + K + A+K+L K ++ K QVEH L + +Q+ + Sbjct: 42 LDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQA-I 100 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 + P ++ L +F D + +Y++LE+ GE++ L++ FSE S Y A + A YLH Sbjct: 101 QFPFLVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLH 160 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 +I+RD+KPENLL+ QG LK+ Sbjct: 161 YLDLIYRDLKPENLLIDSQGYLKV 184
>AKT2_HUMAN (P31751) RAC-beta serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta) Length = 481 Score = 100 bits (249), Expect = 3e-21 Identities = 60/165 (36%), Positives = 91/165 (55%), Gaps = 1/165 (0%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 S S +EE S+ + ++DFD K LG+G FG V L REK + A+K+L K Sbjct: 128 SDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEV 187 Query: 272 L-KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH 448 + + +V H + E + + RHP + L F R+ ++E+A GEL+ L R + Sbjct: 188 IIAKDEVAHTVT-ESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERV 246 Query: 449 FSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 F+E R+ Y A + AL YLH + V++RDIK ENL++ G +KI Sbjct: 247 FTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKI 291
>KAPCA_RAT (P27791) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 100 bits (249), Expect = 3e-21 Identities = 56/158 (35%), Positives = 91/158 (57%), Gaps = 1/158 (0%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQV 289 E PSQ++ + L FD K LG G FG V L + K S + A+K+L K ++ K Q+ Sbjct: 31 EDPSQNTAQ-----LDHFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQI 85 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 EH L + +Q+ + P +++L F D + +Y+++E+ GE++ L+R FSE + Sbjct: 86 EHTLNEKRILQA-VNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 144 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y A + YLH +I+RD+KPENLL+ QG +++ Sbjct: 145 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 182
>SGK1_RAT (Q06226) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 430 Score = 99.8 bits (247), Expect = 5e-21 Identities = 53/141 (37%), Positives = 84/141 (59%), Gaps = 1/141 (0%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ-LKQSQVEHQLRREVEIQSHLR 334 SDF K +G+G FG V LAR K A+KVL K LK+ + +H + + +++ Sbjct: 96 SDFHFLKVIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 155 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP ++ L+ F ++Y +L++ GEL+ LQR + F E R+ Y A +A AL YLH Sbjct: 156 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 215 Query: 515 KHVIHRDIKPENLLVGVQGEL 577 ++++RD+KPEN+L+ QG + Sbjct: 216 LNIVYRDLKPENILLDSQGHI 236
>SGK2_HUMAN (Q9HBY8) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) Length = 427 Score = 99.8 bits (247), Expect = 5e-21 Identities = 53/141 (37%), Positives = 84/141 (59%), Gaps = 1/141 (0%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFK-SQLKQSQVEHQLRREVEIQSHLR 334 +DFD K +G+G +G V LA+ K A+KVL K S LK+ + H + + ++R Sbjct: 93 TDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVR 152 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP ++ L F ++Y +L++ GEL+ LQR + F E R+ Y A +A A+ YLH Sbjct: 153 HPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHS 212 Query: 515 KHVIHRDIKPENLLVGVQGEL 577 ++I+RD+KPEN+L+ QG + Sbjct: 213 LNIIYRDLKPENILLDCQGHV 233
>SGK1_RABIT (Q9XT18) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 99.8 bits (247), Expect = 5e-21 Identities = 53/141 (37%), Positives = 84/141 (59%), Gaps = 1/141 (0%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ-LKQSQVEHQLRREVEIQSHLR 334 SDF K +G+G FG V LAR K A+KVL K LK+ + +H + + +++ Sbjct: 96 SDFHFLKVIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 155 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP ++ L+ F ++Y +L++ GEL+ LQR + F E R+ Y A +A AL YLH Sbjct: 156 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 215 Query: 515 KHVIHRDIKPENLLVGVQGEL 577 ++++RD+KPEN+L+ QG + Sbjct: 216 LNIVYRDLKPENILLDSQGHI 236
>KAPCB_HUMAN (P22694) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 99.8 bits (247), Expect = 5e-21 Identities = 55/158 (34%), Positives = 90/158 (56%), Gaps = 1/158 (0%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQV 289 E P+Q++ L DF+ K LG G FG V L + K + A+K+L K ++ K Q+ Sbjct: 31 ENPTQNNAG-----LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQI 85 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 EH L + +Q+ + P ++RL F D + +Y+++E+ GE++ L+R FSE + Sbjct: 86 EHTLNEKRILQA-VNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 144 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y A + YLH +I+RD+KPENLL+ QG +++ Sbjct: 145 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQV 182
>KAPCA_CRIGR (P25321) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 99.8 bits (247), Expect = 5e-21 Identities = 55/158 (34%), Positives = 91/158 (57%), Gaps = 1/158 (0%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQV 289 E PSQ++ + L FD K LG G FG V L + K + + A+K+L K ++ K Q+ Sbjct: 31 ESPSQNTAQ-----LDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQI 85 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 EH L + +Q+ + P +++L F D + +Y+++E+ GE++ L+R FSE + Sbjct: 86 EHTLNEKRILQA-VNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 144 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y A + YLH +I+RD+KPENLL+ QG +++ Sbjct: 145 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 182
>AKT2_CAEEL (Q9XTG7) Serine/threonine-protein kinase akt-2 (EC 2.7.11.1)| (Protein kinase B akt-2) (PKB akt-2) Length = 528 Score = 99.8 bits (247), Expect = 5e-21 Identities = 57/144 (39%), Positives = 85/144 (59%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 + DFD K LG+G FG V L REK S + A+K++ K + +S+V H L + + + Sbjct: 177 MDDFDFLKVLGQGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTLTENRVLYACV 236 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 HP + L F Q + ++E A GEL+ LQRCK FSE R+ Y + + AL YLH Sbjct: 237 -HPFLTLLKYSFQAQYHICFVMEFANGGELFTHLQRCKTFSEARTRFYGSEIILALGYLH 295 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 +++++RD+K ENLL+ G +KI Sbjct: 296 HRNIVYRDMKLENLLLDRDGHIKI 319
>KIN11_ARATH (P92958) SNF1-related protein kinase catalytic alpha subunit KIN11| (EC 2.7.11.1) (AKIN11) (AKIN alpha1) Length = 512 Score = 99.4 bits (246), Expect = 7e-21 Identities = 47/145 (32%), Positives = 83/145 (57%) Frame = +2 Query: 152 VLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 +L ++ +GK LG G FG V +A + H VA+K+L + ++K ++E ++RRE++I Sbjct: 16 ILPNYKLGKTLGIGSFGKVKIAEHVVTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLF 75 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 HP+I+R Y + +Y+++E+ GEL+ + E + + + + Y H Sbjct: 76 MHPHIIRQYEVIETTSDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCH 135 Query: 512 GKHVIHRDIKPENLLVGVQGELKIA 586 V+HRD+KPENLL+ + +KIA Sbjct: 136 RNMVVHRDLKPENLLLDSRCNIKIA 160
>KAPB2_BOVIN (P24256) cAMP-dependent protein kinase, beta-2-catalytic subunit| (EC 2.7.11.11) (PKA C-beta-2) Length = 397 Score = 99.4 bits (246), Expect = 7e-21 Identities = 52/144 (36%), Positives = 84/144 (58%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 L DF+ K LG G FG V L + K + A+K+L K ++ K Q+EH L + +Q+ + Sbjct: 87 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQA-V 145 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 P ++RL F D + +Y+++E+ GE++ L+R FSE + Y A + YLH Sbjct: 146 NFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 205 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 +I+RD+KPENLL+ QG +++ Sbjct: 206 SLDLIYRDLKPENLLIDHQGYIQV 229
>SGK1_MOUSE (Q9WVC6) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 99.4 bits (246), Expect = 7e-21 Identities = 53/141 (37%), Positives = 84/141 (59%), Gaps = 1/141 (0%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ-LKQSQVEHQLRREVEIQSHLR 334 SDF K +G+G FG V LAR K A+KVL K LK+ + +H + + +++ Sbjct: 96 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 155 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP ++ L+ F ++Y +L++ GEL+ LQR + F E R+ Y A +A AL YLH Sbjct: 156 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 215 Query: 515 KHVIHRDIKPENLLVGVQGEL 577 ++++RD+KPEN+L+ QG + Sbjct: 216 LNIVYRDLKPENILLDSQGHI 236
>SGK1_HUMAN (O00141) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 99.4 bits (246), Expect = 7e-21 Identities = 53/141 (37%), Positives = 84/141 (59%), Gaps = 1/141 (0%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ-LKQSQVEHQLRREVEIQSHLR 334 SDF K +G+G FG V LAR K A+KVL K LK+ + +H + + +++ Sbjct: 96 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 155 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP ++ L+ F ++Y +L++ GEL+ LQR + F E R+ Y A +A AL YLH Sbjct: 156 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 215 Query: 515 KHVIHRDIKPENLLVGVQGEL 577 ++++RD+KPEN+L+ QG + Sbjct: 216 LNIVYRDLKPENILLDSQGHI 236
>KAPCB_RAT (P68182) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 99.4 bits (246), Expect = 7e-21 Identities = 52/144 (36%), Positives = 84/144 (58%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 L DF+ K LG G FG V L + K + A+K+L K ++ K Q+EH L + +Q+ + Sbjct: 40 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQA-V 98 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 P ++RL F D + +Y+++E+ GE++ L+R FSE + Y A + YLH Sbjct: 99 EFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 158 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 +I+RD+KPENLL+ QG +++ Sbjct: 159 SLDLIYRDLKPENLLIDHQGYIQV 182
>KAPCB_PIG (P05383) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 99.4 bits (246), Expect = 7e-21 Identities = 52/144 (36%), Positives = 84/144 (58%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 L DF+ K LG G FG V L + K + A+K+L K ++ K Q+EH L + +Q+ + Sbjct: 40 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQA-V 98 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 P ++RL F D + +Y+++E+ GE++ L+R FSE + Y A + YLH Sbjct: 99 NFPFLVRLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 158 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 +I+RD+KPENLL+ QG +++ Sbjct: 159 SLDLIYRDLKPENLLIDHQGYIQV 182
>KAPCB_MOUSE (P68181) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 99.4 bits (246), Expect = 7e-21 Identities = 52/144 (36%), Positives = 84/144 (58%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 L DF+ K LG G FG V L + K + A+K+L K ++ K Q+EH L + +Q+ + Sbjct: 40 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQA-V 98 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 P ++RL F D + +Y+++E+ GE++ L+R FSE + Y A + YLH Sbjct: 99 EFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 158 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 +I+RD+KPENLL+ QG +++ Sbjct: 159 SLDLIYRDLKPENLLIDHQGYIQV 182
>KAPCB_CRIGR (P68180) cAMP-dependent protein kinase, beta-catalytic subunit (EC| 2.7.11.11) (PKA C-beta) Length = 350 Score = 99.4 bits (246), Expect = 7e-21 Identities = 52/144 (36%), Positives = 84/144 (58%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 L DF+ K LG G FG V L + K + A+K+L K ++ K Q+EH L + +Q+ + Sbjct: 40 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQA-V 98 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 P ++RL F D + +Y+++E+ GE++ L+R FSE + Y A + YLH Sbjct: 99 EFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 158 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 +I+RD+KPENLL+ QG +++ Sbjct: 159 SLDLIYRDLKPENLLIDHQGYIQV 182
>KAPB1_BOVIN (P05131) cAMP-dependent protein kinase, beta-1-catalytic subunit| (EC 2.7.11.11) (PKA C-beta-1) Length = 350 Score = 99.4 bits (246), Expect = 7e-21 Identities = 52/144 (36%), Positives = 84/144 (58%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 L DF+ K LG G FG V L + K + A+K+L K ++ K Q+EH L + +Q+ + Sbjct: 40 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQA-V 98 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 P ++RL F D + +Y+++E+ GE++ L+R FSE + Y A + YLH Sbjct: 99 NFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 158 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 +I+RD+KPENLL+ QG +++ Sbjct: 159 SLDLIYRDLKPENLLIDHQGYIQV 182
>PKD1_DICDI (P34100) Developmentally-regulated protein kinase 1 (EC 2.7.11.1)| (Fragment) Length = 416 Score = 99.4 bits (246), Expect = 7e-21 Identities = 47/147 (31%), Positives = 85/147 (57%) Frame = +2 Query: 143 KRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQ 322 KR +SDF+ +LG G FG L R + S K L + + + + + E+ I Sbjct: 29 KRTKISDFNFYGSLGSGSFGTAKLCRHRGSGLFFCSKTLRRETIVHEKHKEHVNNEINIM 88 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 ++ HP I++ Y F T+++ I+E+A K +L+ L+ K F+E+ + +A + A+ Sbjct: 89 LNISHPYIVKTYSTFNTPTKIHFIMEYAGKKDLFHHLRANKCFTEQTTKLIVAEIVLAIE 148 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKI 583 YLH +++I+RD+KPEN+L+ +G +K+ Sbjct: 149 YLHAENIIYRDLKPENILIDEKGHIKL 175
>KAPC_ASCSU (P49673) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 337 Score = 99.0 bits (245), Expect = 9e-21 Identities = 52/144 (36%), Positives = 83/144 (57%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVL-FKSQLKQSQVEHQLRREVEIQSHL 331 + DFD +G G FG VYL + + S ALK + + + Q EH + E + S L Sbjct: 26 VDDFDRICTIGTGSFGRVYLVQHRASEQYFALKKMAIREVVSMRQTEH-VHSEKRLLSRL 84 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 HP I+++Y +D+ +Y++ E+ A GEL+ L+ + FS + Y A + AL YLH Sbjct: 85 SHPFIVKMYCASWDKYNLYMLFEYLAGGELFSYLRASRTFSNSMARFYAAEIVCALQYLH 144 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 K++ +RD+KPENL++ +G LK+ Sbjct: 145 SKNIAYRDLKPENLMLNKEGHLKM 168
>SGK2_MOUSE (Q9QZS5) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) Length = 367 Score = 99.0 bits (245), Expect = 9e-21 Identities = 53/141 (37%), Positives = 83/141 (58%), Gaps = 1/141 (0%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFK-SQLKQSQVEHQLRREVEIQSHLR 334 +DFD K +G+G +G V LA+ K A+KVL K S LK + H + + ++R Sbjct: 33 TDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQNHIMAERNVLLKNVR 92 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP ++ L F ++Y +L++ GEL+ LQR + F E R+ Y A +A A+ YLH Sbjct: 93 HPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYTAEVASAIGYLHS 152 Query: 515 KHVIHRDIKPENLLVGVQGEL 577 ++I+RD+KPEN+L+ QG + Sbjct: 153 LNIIYRDLKPENILLDCQGHV 173
>SN1L1_MOUSE (Q60670) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1-like kinase) Length = 779 Score = 99.0 bits (245), Expect = 9e-21 Identities = 50/141 (35%), Positives = 83/141 (58%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 +DV + LG+G F V LAR + + VA+K++ K++L S +E ++ REV++ L HPN Sbjct: 27 YDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE-KIYREVQLMKLLNHPN 85 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I++LY + +Y++ E A GE++ L H SE + + A+ Y H H+ Sbjct: 86 IIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQILSAVEYCHNHHI 145 Query: 524 IHRDIKPENLLVGVQGELKIA 586 +HRD+K ENLL+ ++K+A Sbjct: 146 VHRDLKTENLLLDSNMDIKLA 166
>SN1L2_CHICK (Q9IA88) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 798 Score = 99.0 bits (245), Expect = 9e-21 Identities = 55/168 (32%), Positives = 91/168 (54%) Frame = +2 Query: 83 MAISTDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLF 262 M I ++ S PS R + +D+ + LG+G F V LAR + + VA+K++ Sbjct: 1 MVIMSEDASVPAPSAAQPRPLR--VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIID 58 Query: 263 KSQLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRC 442 K++L S +E ++ REV+I L HP+I++LY + +Y++ E A GE++ L Sbjct: 59 KTRLDPSNLE-KIYREVQIMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDHLTSN 117 Query: 443 KHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 H SE + + A+ Y H H++HRD+K ENLL+ +K+A Sbjct: 118 GHLSESEARKKFWQILSAVEYCHSHHIVHRDLKTENLLLDANMNIKLA 165
>CIPK1_ORYSA (Q6X4A2) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1)| Length = 449 Score = 99.0 bits (245), Expect = 9e-21 Identities = 44/141 (31%), Positives = 82/141 (58%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 +++G+ +G G F V A+ + VA+K+L K ++++ ++ Q+RRE+ ++HPN Sbjct: 20 YELGRTIGEGTFAKVRFAKNTENDEPVAIKILDKEKVQKHRLVEQIRREICTMKLVKHPN 79 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 ++RL+ + R++++LE+ GEL++ + E + Y L A+ Y H + V Sbjct: 80 VVRLFEVMGSKARIFIVLEYVTGGELFEIIATNGRLKEEEARKYFQQLINAVDYCHSRGV 139 Query: 524 IHRDIKPENLLVGVQGELKIA 586 HRD+K ENLL+ G LK++ Sbjct: 140 YHRDLKLENLLLDASGNLKVS 160
>KAPCG_MACMU (O62846) cAMP-dependent protein kinase, gamma-catalytic subunit (EC| 2.7.11.11) (PKA C-gamma) (Fragment) Length = 208 Score = 98.6 bits (244), Expect = 1e-20 Identities = 52/141 (36%), Positives = 85/141 (60%), Gaps = 1/141 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHLRHP 340 F+ K LG G +G V L R + + + A+K+L K ++ + QVEH L + +Q+ + P Sbjct: 42 FERLKTLGTGSYGRVMLVRHRETGNHYAMKILDKQKVVRLKQVEHTLNEKRILQA-INFP 100 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKH 520 +++L F D + +YL++E+ GE++ L+R FSE ++ Y A + A YLH Sbjct: 101 FLVKLQFSFKDNSNLYLVMEYVPGGEMFSHLRRVGRFSEPQACFYAAQVVLAFQYLHSLD 160 Query: 521 VIHRDIKPENLLVGVQGELKI 583 +IHRD+KPENLL+ QG L++ Sbjct: 161 LIHRDLKPENLLIDQQGYLQV 181
>AKT1_XENLA (Q98TY9) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (Protein kinase Akt-1) (Protein kinase B, alpha) (PKB alpha) (xAkt) Length = 481 Score = 98.6 bits (244), Expect = 1e-20 Identities = 60/166 (36%), Positives = 95/166 (57%), Gaps = 2/166 (1%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 S +S +EE HS+ + + +++F+ K LG+G FG V L +EK + A+K+L K Sbjct: 127 SDNSGAEEMEVSHSKPKHKVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV 186 Query: 272 L-KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH 448 + + +V H L E + + RHP + L F R+ ++E+A GEL+ L R + Sbjct: 187 IVAKDEVAHTL-TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERI 245 Query: 449 FSERRSATYIASLARALIYLHG-KHVIHRDIKPENLLVGVQGELKI 583 FSE R+ Y A + AL YLH K+V++RD+K ENL++ G +KI Sbjct: 246 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 291
>SN1L1_RAT (Q9R1U5) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (Salt-inducible protein kinase) (Protein kinase KID2) Length = 776 Score = 98.6 bits (244), Expect = 1e-20 Identities = 50/141 (35%), Positives = 83/141 (58%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 +DV + LG+G F V LAR + + VA+K++ K++L S +E ++ REV++ L HPN Sbjct: 27 YDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE-KIYREVQLMKLLNHPN 85 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I++LY + +Y++ E A GE++ L H SE + + A+ Y H H+ Sbjct: 86 IIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHNHHI 145 Query: 524 IHRDIKPENLLVGVQGELKIA 586 +HRD+K ENLL+ ++K+A Sbjct: 146 VHRDLKTENLLLDGNMDIKLA 166
>KPK1_ARATH (P42818) Serine/threonine-protein kinase AtPK1/AtPK6 (EC 2.7.11.1)| Length = 465 Score = 98.2 bits (243), Expect = 2e-20 Identities = 49/143 (34%), Positives = 83/143 (58%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + DF+V K +G+G FG VY R+K +S I A+KV+ K + + ++ E +I + + Sbjct: 131 IDDFEVMKVVGKGAFGKVYQVRKKETSEIYAMKVMRKDHIMEKNHAEYMKAERDILTKID 190 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP I++L F + R+YL+L+ G L+ +L F E + Y A + A+ +LH Sbjct: 191 HPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHE 250 Query: 515 KHVIHRDIKPENLLVGVQGELKI 583 K ++HRD+KPEN+L+ G + + Sbjct: 251 KGIMHRDLKPENILMDTDGHVML 273
>KAPCG_HUMAN (P22612) cAMP-dependent protein kinase, gamma-catalytic subunit (EC| 2.7.11.11) (PKA C-gamma) Length = 350 Score = 98.2 bits (243), Expect = 2e-20 Identities = 54/141 (38%), Positives = 84/141 (59%), Gaps = 1/141 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHLRHP 340 F+ + LG G FG V L R + + A+K+L K ++ K QVEH L + +Q+ + P Sbjct: 43 FERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQA-IDFP 101 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKH 520 +++L F D + +YL++E+ GE++ LQR FSE + Y A + A+ YLH Sbjct: 102 FLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLD 161 Query: 521 VIHRDIKPENLLVGVQGELKI 583 +IHRD+KPENLL+ QG L++ Sbjct: 162 LIHRDLKPENLLIDQQGYLQV 182
>AKT2A_XENLA (Q7ZX15) RAC-beta serine/threonine-protein kinase-A (EC 2.7.11.1)| (RAC-PK-beta-A) (Protein kinase Akt-2-A) (Protein kinase B, beta-A) (PKB beta-A) Length = 486 Score = 97.8 bits (242), Expect = 2e-20 Identities = 58/162 (35%), Positives = 91/162 (56%), Gaps = 1/162 (0%) Frame = +2 Query: 101 SRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-K 277 S +E+ S+ + ++DFD K LG+G FG V L REK + A+K+L K + Sbjct: 136 SSAEQMDVAMSKGHPKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIA 195 Query: 278 QSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSE 457 + +V H L E + + +HP + L F R+ ++E+A GEL+ L R + F+E Sbjct: 196 KDEVAHTLT-ESRVLQNTKHPFLTALKYAFQTSDRLCFVMEYANGGELFFHLSRERVFTE 254 Query: 458 RRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 R+ Y A + AL YLH ++V++RDIK ENL++ G +KI Sbjct: 255 DRARFYGAEIVSALEYLHSRNVVYRDIKLENLMLDKDGHVKI 296
>SGK2_RAT (Q8R4U9) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) (Fragment) Length = 302 Score = 97.8 bits (242), Expect = 2e-20 Identities = 53/141 (37%), Positives = 82/141 (58%), Gaps = 1/141 (0%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFK-SQLKQSQVEHQLRREVEIQSHLR 334 +DFD K +G+G +G V LA+ K A+KVL K S LK + H + + ++R Sbjct: 16 TDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQSHIMAERNVLLKNVR 75 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP ++ L F ++Y +L++ GEL+ LQR F E R+ Y A +A A+ YLH Sbjct: 76 HPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQREHRFLEPRARFYTAEVASAIGYLHS 135 Query: 515 KHVIHRDIKPENLLVGVQGEL 577 ++I+RD+KPEN+L+ QG + Sbjct: 136 LNIIYRDLKPENILLDCQGHV 156
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 97.4 bits (241), Expect = 3e-20 Identities = 53/143 (37%), Positives = 86/143 (60%), Gaps = 3/143 (2%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKR---SSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 F++ K LG+G FG V+L R+ R S H+ A+KVL K+ LK + + E I +H+ Sbjct: 104 FELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRD-RQRTKLERNILAHIS 162 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP I++L+ F + ++YLIL+ G+L+ L + F+E Y+A L AL +LH Sbjct: 163 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHS 222 Query: 515 KHVIHRDIKPENLLVGVQGELKI 583 +++RD+KPEN+L+ G +K+ Sbjct: 223 LGIVYRDLKPENILLDADGHIKV 245 Score = 61.6 bits (148), Expect = 2e-09 Identities = 38/137 (27%), Positives = 70/137 (51%), Gaps = 1/137 (0%) Frame = +2 Query: 161 DFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHP 340 D+++ + +G G V+ + K + A+K++ K+ ++ L R H H Sbjct: 453 DYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDILLR------HSHHQ 506 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHF-SERRSATYIASLARALIYLHGK 517 +++L+ + D+T +Y+I E GEL +L K SE+ A +A+L A+ YLH + Sbjct: 507 FVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQ 566 Query: 518 HVIHRDIKPENLLVGVQ 568 V HRD+ N+L ++ Sbjct: 567 QVAHRDLTAANILFALK 583
>SN1L1_HUMAN (P57059) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) Length = 783 Score = 97.4 bits (241), Expect = 3e-20 Identities = 51/160 (31%), Positives = 90/160 (56%) Frame = +2 Query: 107 SEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQ 286 S + Q ++K + +D+ + LG+G F V LAR + + VA+K++ K++L S Sbjct: 8 SADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSN 67 Query: 287 VEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRS 466 +E ++ REV++ L HP+I++LY + +Y++ E A GE++ L H SE + Sbjct: 68 LE-KIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEA 126 Query: 467 ATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + A+ Y H H++HRD+K ENLL+ ++K+A Sbjct: 127 RKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLA 166
>PSK1_SCHPO (Q12706) Serine/threonine-protein kinase psk1 (EC 2.7.11.22)| Length = 436 Score = 97.1 bits (240), Expect = 3e-20 Identities = 54/141 (38%), Positives = 81/141 (57%), Gaps = 1/141 (0%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLK-QSQVEHQLRREVEIQSHLR 334 +DF LGRG +G V L ++K + + A K L K+ + +++ Q + E +I +R Sbjct: 89 ADFQPLTVLGRGSYGKVLLVKQKNTGRLFAQKQLKKASIVLRAKGLEQTKNERQILEEVR 148 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP I RLY F D R+YLIL++A GEL+ L + E A Y A L ALI+LH Sbjct: 149 HPFICRLYYAFQDHDRLYLILQYAPGGELFSHLAEQRMLPEDVVAFYTAELTLALIHLHK 208 Query: 515 KHVIHRDIKPENLLVGVQGEL 577 +++RD+KPEN L+ +G + Sbjct: 209 LGIVYRDLKPENCLLDAEGHI 229
>CDPK_DAUCA (P28582) Calcium-dependent protein kinase (EC 2.7.11.1) (CDPK)| Length = 532 Score = 97.1 bits (240), Expect = 3e-20 Identities = 55/157 (35%), Positives = 82/157 (52%), Gaps = 9/157 (5%) Frame = +2 Query: 116 KPSQHSQEEKRWVLSD--------FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 KP Q + E +L + +GK LGRG+FG VY E S + A K + K + Sbjct: 57 KPRQVHRPESNTILGKPFEDIRGKYTLGKELGRGQFGCVYQCTENSSGQLYACKSILKRK 116 Query: 272 LKQSQVEHQLRREVEIQSHLR-HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH 448 L + ++RE++I HL PNI+ G F D+ V+L++E A GEL+ + H Sbjct: 117 LVSKNDKEDIKREIQILQHLSGQPNIVEFKGVFEDRQSVHLVMELCAGGELFDRIIAQGH 176 Query: 449 FSERRSATYIASLARALIYLHGKHVIHRDIKPENLLV 559 +SER +AT + + H V+HRD+KPEN L+ Sbjct: 177 YSERAAATICRQIVNVVHVCHFMGVMHRDLKPENFLL 213
>AKT2_MOUSE (Q60823) RAC-beta serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta) Length = 481 Score = 97.1 bits (240), Expect = 3e-20 Identities = 59/165 (35%), Positives = 90/165 (54%), Gaps = 1/165 (0%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 S S SE ++ + ++DFD K LG+G FG V L REK + A+K+L K Sbjct: 128 SDSSTSEMMEVAVNKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEV 187 Query: 272 L-KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH 448 + + +V H + E + + RHP + L F R+ ++E+A GEL+ L R + Sbjct: 188 IIAKDEVAHTVT-ESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERV 246 Query: 449 FSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 F+E R+ Y A + AL YLH + V++RDIK ENL++ G +KI Sbjct: 247 FTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKI 291
>KPCE_RABIT (P10830) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 736 Score = 96.7 bits (239), Expect = 4e-20 Identities = 60/170 (35%), Positives = 91/170 (53%), Gaps = 3/170 (1%) Frame = +2 Query: 86 AISTDSR--SEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVL 259 A STD + S E + KR L +F+ K LG+G FG V LA K + A+KVL Sbjct: 379 ASSTDGQLGSPENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVL 438 Query: 260 FKSQLKQSQVEHQLRREVEIQSHLR-HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQ 436 K + Q E I + R HP + +LY F + R++ ++E+ G+L ++Q Sbjct: 439 KKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQ 498 Query: 437 RCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 R + F E RS Y A + AL++LH VI+RD+K +N+L+ +G K+A Sbjct: 499 RSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLA 548
>KAPCA_CANFA (Q8MJ44) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 349 Score = 96.7 bits (239), Expect = 4e-20 Identities = 53/158 (33%), Positives = 90/158 (56%), Gaps = 1/158 (0%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQV 289 E P+Q++ L F+ K LG G FG V L + K + + A+K+L K ++ K Q+ Sbjct: 30 ENPAQNTAH-----LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQI 84 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 EH L + +Q+ + P +++L F D + +Y+++E+ GE++ L+R FSE + Sbjct: 85 EHTLNEKRILQA-VNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 143 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y A + YLH +I+RD+KPENLL+ QG +++ Sbjct: 144 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 181
>KAPCA_PIG (P36887) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 96.7 bits (239), Expect = 4e-20 Identities = 53/158 (33%), Positives = 90/158 (56%), Gaps = 1/158 (0%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQV 289 E P+Q++ L F+ K LG G FG V L + K + + A+K+L K ++ K Q+ Sbjct: 31 ENPAQNTAH-----LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQI 85 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 EH L + +Q+ + P +++L F D + +Y+++E+ GE++ L+R FSE + Sbjct: 86 EHTLNEKRILQA-VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 144 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y A + YLH +I+RD+KPENLL+ QG +++ Sbjct: 145 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 182
>KAPCA_HUMAN (P17612) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 96.7 bits (239), Expect = 4e-20 Identities = 53/158 (33%), Positives = 90/158 (56%), Gaps = 1/158 (0%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQV 289 E P+Q++ L F+ K LG G FG V L + K + + A+K+L K ++ K Q+ Sbjct: 31 ESPAQNTAH-----LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQI 85 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 EH L + +Q+ + P +++L F D + +Y+++E+ GE++ L+R FSE + Sbjct: 86 EHTLNEKRILQA-VNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 144 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y A + YLH +I+RD+KPENLL+ QG +++ Sbjct: 145 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 182
>AKT2B_XENLA (Q6IP76) RAC-beta serine/threonine-protein kinase-B (EC 2.7.11.1)| (RAC-PK-beta-B) (Protein kinase Akt-2-B) (Protein kinase B, beta-B) (PKB beta-B) Length = 485 Score = 96.3 bits (238), Expect = 6e-20 Identities = 58/162 (35%), Positives = 91/162 (56%), Gaps = 1/162 (0%) Frame = +2 Query: 101 SRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-K 277 S +E+ S+ + ++DFD K LG+G FG V L REK + A+K+L K + Sbjct: 135 SSAEQMDVAMSKGRPKVTMNDFDYLKLLGKGTFGKVILVREKATGLYYAMKILRKEVIIA 194 Query: 278 QSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSE 457 + +V H L E + + +HP + L F R+ ++E+A GEL+ L R + F+E Sbjct: 195 KDEVAHTLT-ESRVLQNTKHPFLTGLKYAFQTSDRLCFVMEYANGGELFFHLSRERVFTE 253 Query: 458 RRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 R+ Y A + AL YLH ++V++RDIK ENL++ G +KI Sbjct: 254 DRARFYGAEIVSALEYLHSRNVVYRDIKLENLMLDKDGHVKI 295
>AKT2_RAT (P47197) RAC-beta serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta) Length = 481 Score = 95.9 bits (237), Expect = 8e-20 Identities = 59/165 (35%), Positives = 89/165 (53%), Gaps = 1/165 (0%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 S S SE S+ + ++DFD K LG+G FG V L REK + A+K+L K Sbjct: 128 SDSSTSEMMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEV 187 Query: 272 L-KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH 448 + + +V H + E + + RHP + L F R+ ++E+A G+L+ L R + Sbjct: 188 IIAKDEVAHTVT-ESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGDLFFHLSRERV 246 Query: 449 FSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 F+E R+ Y A + AL YLH V++RDIK ENL++ G +KI Sbjct: 247 FTEDRARFYGAEIVSALEYLHSTDVVYRDIKLENLMLDKDGHIKI 291
>CIPK1_ARATH (Q8RWC9) CBL-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (SOS2-like protein kinase PKS13) (SNF1-related kinase 3.16) Length = 444 Score = 95.9 bits (237), Expect = 8e-20 Identities = 47/156 (30%), Positives = 83/156 (53%) Frame = +2 Query: 116 KPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEH 295 + + + EK L +++G+ LG G FG V A++ S H A+K++ KS++ Sbjct: 4 RQEEEKKAEKGMRLGKYELGRTLGEGNFGKVKFAKDTVSGHSFAVKIIDKSRIADLNFSL 63 Query: 296 QLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATY 475 Q++RE+ L+HP+I+RL+ +T++ +++E GEL+ + +E Sbjct: 64 QIKREIRTLKMLKHPHIVRLHEVLASKTKINMVMELVTGGELFDRIVSNGKLTETDGRKM 123 Query: 476 IASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 L + Y H K V HRD+K EN+L+ +G +KI Sbjct: 124 FQQLIDGISYCHSKGVFHRDLKLENVLLDAKGHIKI 159
>AKT1_CAEEL (Q17941) Serine/threonine-protein kinase akt-1 (EC 2.7.11.1)| (Protein kinase B akt-1) (PKB akt-1) Length = 541 Score = 95.9 bits (237), Expect = 8e-20 Identities = 54/145 (37%), Positives = 84/145 (57%), Gaps = 1/145 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 + DFD K LG+G FG V L +EKR+ + A+K+L K + + +V H L E + Sbjct: 190 MEDFDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLT-ENRVLQRC 248 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 +HP + L F +Q + +++ A GEL+ +++C FSE R+ Y A + AL YLH Sbjct: 249 KHPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSEPRARFYGAEIVLALGYLH 308 Query: 512 GKHVIHRDIKPENLLVGVQGELKIA 586 +++RD+K ENLL+ G +KIA Sbjct: 309 RCDIVYRDMKLENLLLDKDGHIKIA 333
>KPC2_APLCA (Q16975) Calcium-independent protein kinase C (EC 2.7.11.13) (APL| II) Length = 743 Score = 95.9 bits (237), Expect = 8e-20 Identities = 55/161 (34%), Positives = 90/161 (55%), Gaps = 1/161 (0%) Frame = +2 Query: 107 SEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQ 286 S+ S HS R L DF+ K LG+G FG V LA +K + + A+KVL K + Q Sbjct: 388 SDRSRSHHS----RISLHDFNFIKVLGKGSFGKVMLAEKKGTDEVYAIKVLKKDVIIQDD 443 Query: 287 -VEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERR 463 VE + + + +HP + L+ F + R++ ++E+ G+L ++QR + F E R Sbjct: 444 DVECTMTEKRILALSAKHPFLTALHSSFQTKERLFFVMEYVNGGDLMFQIQRARKFDEPR 503 Query: 464 SATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + Y A + AL++LH +I+RD+K +N+L+ +G KIA Sbjct: 504 ARFYAAEVTLALMFLHRHGIIYRDLKLDNILLDAEGHCKIA 544
>MARK4_MOUSE (Q8CIP4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| Length = 752 Score = 95.5 bits (236), Expect = 1e-19 Identities = 48/137 (35%), Positives = 81/137 (59%) Frame = +2 Query: 176 KALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPNILRL 355 + +G+G F V LAR + VA+K++ K+QL S ++ +L REV I L HPNI++L Sbjct: 63 RTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ-KLFREVRIMKGLNHPNIVKL 121 Query: 356 YGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVIHRD 535 + + +YL++E+A+ GE++ L E+ + + A+ Y H K+++HRD Sbjct: 122 FEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRD 181 Query: 536 IKPENLLVGVQGELKIA 586 +K ENLL+ + +KIA Sbjct: 182 LKAENLLLDAEANIKIA 198
>MARK4_HUMAN (Q96L34) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase-like 1) Length = 752 Score = 95.5 bits (236), Expect = 1e-19 Identities = 48/137 (35%), Positives = 81/137 (59%) Frame = +2 Query: 176 KALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPNILRL 355 + +G+G F V LAR + VA+K++ K+QL S ++ +L REV I L HPNI++L Sbjct: 63 RTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ-KLFREVRIMKGLNHPNIVKL 121 Query: 356 YGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVIHRD 535 + + +YL++E+A+ GE++ L E+ + + A+ Y H K+++HRD Sbjct: 122 FEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRD 181 Query: 536 IKPENLLVGVQGELKIA 586 +K ENLL+ + +KIA Sbjct: 182 LKAENLLLDAEANIKIA 198
>KPCE_RAT (P09216) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 95.5 bits (236), Expect = 1e-19 Identities = 61/184 (33%), Positives = 96/184 (52%), Gaps = 17/184 (9%) Frame = +2 Query: 86 AISTDSRSEE------------KPSQHSQ----EEKRWVLSDFDVGKALGRGKFGHVYLA 217 A+S D+R EE P ++ + + KR L +F+ K LG+G FG V LA Sbjct: 366 ALSFDNRGEEHRASSSTDGQLASPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLA 425 Query: 218 REKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR-HPNILRLYGYFYDQTRVYLI 394 K + A+KVL K + Q E I + R HP + +LY F + R++ + Sbjct: 426 ELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFV 485 Query: 395 LEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGE 574 +E+ G+L ++QR + F E RS Y A + AL++LH VI+RD+K +N+L+ +G Sbjct: 486 MEYVNGGDLMFQIQRSRKFDEPRSGFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGH 545 Query: 575 LKIA 586 K+A Sbjct: 546 SKLA 549
>KPCE_MOUSE (P16054) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 95.5 bits (236), Expect = 1e-19 Identities = 61/184 (33%), Positives = 96/184 (52%), Gaps = 17/184 (9%) Frame = +2 Query: 86 AISTDSRSEE------------KPSQHSQ----EEKRWVLSDFDVGKALGRGKFGHVYLA 217 A+S D+R EE P ++ + + KR L +F+ K LG+G FG V LA Sbjct: 366 ALSFDNRGEEHRASSATDGQLASPGENGEVRPGQAKRLGLDEFNFIKVLGKGSFGKVMLA 425 Query: 218 REKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR-HPNILRLYGYFYDQTRVYLI 394 K + A+KVL K + Q E I + R HP + +LY F + R++ + Sbjct: 426 ELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFV 485 Query: 395 LEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGE 574 +E+ G+L ++QR + F E RS Y A + AL++LH VI+RD+K +N+L+ +G Sbjct: 486 MEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGH 545 Query: 575 LKIA 586 K+A Sbjct: 546 CKLA 549
>KPCE_HUMAN (Q02156) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 95.5 bits (236), Expect = 1e-19 Identities = 61/184 (33%), Positives = 96/184 (52%), Gaps = 17/184 (9%) Frame = +2 Query: 86 AISTDSRSEE------------KPSQHSQ----EEKRWVLSDFDVGKALGRGKFGHVYLA 217 A+S D+R EE P ++ + + KR L +F+ K LG+G FG V LA Sbjct: 366 ALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLA 425 Query: 218 REKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR-HPNILRLYGYFYDQTRVYLI 394 K + A+KVL K + Q E I + R HP + +LY F + R++ + Sbjct: 426 ELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFV 485 Query: 395 LEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGE 574 +E+ G+L ++QR + F E RS Y A + AL++LH VI+RD+K +N+L+ +G Sbjct: 486 MEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGH 545 Query: 575 LKIA 586 K+A Sbjct: 546 CKLA 549
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 95.5 bits (236), Expect = 1e-19 Identities = 55/146 (37%), Positives = 91/146 (62%), Gaps = 4/146 (2%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSS---HIVALKVLFKSQLK-QSQVEHQLRREVEIQS 325 S F++ K LG+G +G V+L R+ S + A+KVL K+ LK + +V ++ R+ I + Sbjct: 57 SQFELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVRSKMERD--ILA 114 Query: 326 HLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIY 505 + HP I++L+ F + ++YLIL+ G+L+ L + F+E Y+A LA AL + Sbjct: 115 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 174 Query: 506 LHGKHVIHRDIKPENLLVGVQGELKI 583 LHG +I+RD+KPEN+L+ +G +KI Sbjct: 175 LHGLGIIYRDLKPENILLDEEGHIKI 200 Score = 71.6 bits (174), Expect = 2e-12 Identities = 42/132 (31%), Positives = 72/132 (54%), Gaps = 1/132 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL-RHP 340 +++ + +G G + K + A+K++ KS+ S+ E+EI +HP Sbjct: 415 YEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPSE-------EIEILLRYGQHP 467 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKH 520 NI+ L + D VYL++E GEL + R + FSER ++ + ++AR + YLH + Sbjct: 468 NIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYLHSQG 527 Query: 521 VIHRDIKPENLL 556 V+HRD+KP N+L Sbjct: 528 VVHRDLKPSNIL 539
>MYLK_DICDI (P25323) Myosin light chain kinase (EC 2.7.11.18) (MLCK)| Length = 295 Score = 95.5 bits (236), Expect = 1e-19 Identities = 49/132 (37%), Positives = 79/132 (59%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 ++ + LGRG F VYL K++ A+KV+ KS+L + E L+ EV+I + HPN Sbjct: 8 YEFKEELGRGAFSIVYLGENKQTKQRYAIKVINKSELGKDY-EKNLKMEVDILKKVNHPN 66 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I+ L F ++YL++E GEL+ ++ +SE +A + + A+ YLHG ++ Sbjct: 67 IIALKELFDTPEKLYLVMELVTGGELFDKIVEKGSYSEADAANLVKKIVSAVGYLHGLNI 126 Query: 524 IHRDIKPENLLV 559 +HRD+KPENLL+ Sbjct: 127 VHRDLKPENLLL 138
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 95.1 bits (235), Expect = 1e-19 Identities = 54/147 (36%), Positives = 91/147 (61%), Gaps = 5/147 (3%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLARE---KRSSHIVALKVLFKSQLKQSQVEHQLRREVE--IQ 322 S F++ K LG+G FG V+L R+ S+H+ A+KVL K+ LK V ++R ++E I Sbjct: 78 SQFELLKVLGQGSFGKVFLVRKITPPDSNHLYAMKVLKKATLK---VRDRVRTKIERDIL 134 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 + + HP +++L+ F + ++YLIL+ G+L+ L + F+E Y+A LA L Sbjct: 135 ADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLD 194 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKI 583 +LH +I+RD+KPEN+L+ +G +K+ Sbjct: 195 HLHSLGIIYRDLKPENILLDEEGHIKL 221 Score = 72.0 bits (175), Expect = 1e-12 Identities = 44/130 (33%), Positives = 72/130 (55%), Gaps = 1/130 (0%) Frame = +2 Query: 170 VGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL-RHPNI 346 V +A+G G + K ++ A+KV+ KS+ S+ E+EI +HPNI Sbjct: 437 VKEAIGVGSYSVCKRCIHKTTNMEYAVKVIDKSKRDPSE-------EIEILLRYGQHPNI 489 Query: 347 LRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVI 526 + L + D VYL+ E GEL ++ R K FSER +++ + ++ + + YLH + V+ Sbjct: 490 ITLKDVYDDGKYVYLVTELMRGGELLDKILRQKFFSEREASSVLHTICKTVEYLHSQGVV 549 Query: 527 HRDIKPENLL 556 HRD+KP N+L Sbjct: 550 HRDLKPSNIL 559
>KCC4_YEAST (P25389) Probable serine/threonine-protein kinase KCC4 (EC| 2.7.11.1) Length = 1037 Score = 95.1 bits (235), Expect = 1e-19 Identities = 58/173 (33%), Positives = 87/173 (50%), Gaps = 8/173 (4%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 +T++ S KPS + + +G+ LG G G V LA+ +R+ H A+KV+ KS Sbjct: 5 NTETHSAAKPSS--------TIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSI 56 Query: 272 LKQ--------SQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYK 427 S + + + RE+ I L HPN+L LY + +YLILE+A KGEL+ Sbjct: 57 FNNNGNHSNDDSVLPYNIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFN 116 Query: 428 ELQRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 L ER + + + Y H ++HRD+KPENLL+ +KIA Sbjct: 117 LLVDHGPLPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLLDSFYNIKIA 169
>SGK3_MOUSE (Q9ERE3) Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) (Cytokine independent survival kinase) Length = 496 Score = 94.7 bits (234), Expect = 2e-19 Identities = 56/168 (33%), Positives = 88/168 (52%), Gaps = 8/168 (4%) Frame = +2 Query: 98 DSRSEEKPSQHSQE-------EKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKV 256 D RS KP S+ +DFD K +G+G FG V LA+ K A+KV Sbjct: 133 DERSTSKPHSTSRNINLGPTGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKV 192 Query: 257 LFKS-QLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKEL 433 L K L + + +H + + +++HP ++ L+ F ++Y +L+ GEL+ L Sbjct: 193 LQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHL 252 Query: 434 QRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGEL 577 QR + F E R+ Y A +A AL YLH +++RD+KPEN+L+ G + Sbjct: 253 QRERSFPEPRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSMGHV 300
>SCK2_SCHPO (Q10364) Serine/threonine-protein kinase sck2 (EC 2.7.11.1)| Length = 646 Score = 94.7 bits (234), Expect = 2e-19 Identities = 59/157 (37%), Positives = 90/157 (57%), Gaps = 3/157 (1%) Frame = +2 Query: 122 SQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQ 298 SQHS DF K +G+G FG VYL R+K + + A+KVL K + ++ +V H Sbjct: 257 SQHSYGP-----DDFVPLKLIGKGTFGQVYLVRKKDTERVYAMKVLSKKVIVRRKEVAHT 311 Query: 299 L-RREVEIQ-SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSAT 472 + R++ +Q S P I+ L F +YL+ ++ A GEL+ LQ+ F E R+ Sbjct: 312 VGERDILVQTSAADSPFIVALRFSFQTPKDLYLVTDYMAGGELFWHLQKSVRFPEERAKF 371 Query: 473 YIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 YIA L AL LH + +++RD+KPEN+L+ VQG + + Sbjct: 372 YIAELLLALQALHKRGIVYRDLKPENILLDVQGHIAL 408
>KAPCA_SHEEP (Q9MZD9) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 94.4 bits (233), Expect = 2e-19 Identities = 52/158 (32%), Positives = 89/158 (56%), Gaps = 1/158 (0%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQV 289 E P+Q++ L F+ K LG G FG V L + + + A+K+L K ++ K Q+ Sbjct: 31 ENPAQNTAH-----LDQFERIKTLGTGSFGRVMLVKHTETGNHYAMKILDKQKVVKLKQI 85 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 EH L + +Q+ + P +++L F D + +Y+++E+ GE++ L+R FSE + Sbjct: 86 EHTLNEKRILQA-VNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 144 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y A + YLH +I+RD+KPENLL+ QG +++ Sbjct: 145 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 182
>KAPCA_BOVIN (P00517) cAMP-dependent protein kinase, alpha-catalytic subunit (EC| 2.7.11.11) (PKA C-alpha) Length = 350 Score = 94.4 bits (233), Expect = 2e-19 Identities = 52/158 (32%), Positives = 89/158 (56%), Gaps = 1/158 (0%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQV 289 E P+Q++ L F+ K LG G FG V L + + + A+K+L K ++ K Q+ Sbjct: 31 ENPAQNTAH-----LDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQI 85 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 EH L + +Q+ + P +++L F D + +Y+++E+ GE++ L+R FSE + Sbjct: 86 EHTLNEKRILQA-VNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 144 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y A + YLH +I+RD+KPENLL+ QG +++ Sbjct: 145 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 182
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 94.4 bits (233), Expect = 2e-19 Identities = 54/146 (36%), Positives = 91/146 (62%), Gaps = 4/146 (2%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSS---HIVALKVLFKSQLK-QSQVEHQLRREVEIQS 325 S F++ K LG+G +G V+L R+ + S + A+KVL K+ LK + +V ++ R+ I + Sbjct: 57 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERD--ILA 114 Query: 326 HLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIY 505 + HP I++L+ F + ++YLIL+ G+L+ L + F+E Y+A LA AL + Sbjct: 115 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 174 Query: 506 LHGKHVIHRDIKPENLLVGVQGELKI 583 LH +I+RD+KPEN+L+ +G +KI Sbjct: 175 LHSLGIIYRDLKPENILLDEEGHIKI 200 Score = 71.2 bits (173), Expect = 2e-12 Identities = 40/132 (30%), Positives = 72/132 (54%), Gaps = 1/132 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL-RHP 340 +++ + +G G + K + A+K++ KS+ S+ E+EI +HP Sbjct: 415 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSE-------EIEILLRYGQHP 467 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKH 520 NI+ L + D VYL++E GEL + R ++FSER ++ + ++ + + YLH + Sbjct: 468 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQG 527 Query: 521 VIHRDIKPENLL 556 V+HRD+KP N+L Sbjct: 528 VVHRDLKPSNIL 539
>SGK3_HUMAN (Q96BR1) Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) Length = 496 Score = 94.4 bits (233), Expect = 2e-19 Identities = 50/141 (35%), Positives = 81/141 (57%), Gaps = 1/141 (0%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKS-QLKQSQVEHQLRREVEIQSHLR 334 +DFD K +G+G FG V LA+ K A+KVL K L + + +H + + +++ Sbjct: 160 TDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVK 219 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP ++ L+ F ++Y +L+ GEL+ LQR + F E R+ Y A +A AL YLH Sbjct: 220 HPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHS 279 Query: 515 KHVIHRDIKPENLLVGVQGEL 577 +++RD+KPEN+L+ G + Sbjct: 280 IKIVYRDLKPENILLDSVGHV 300
>AKT1_MOUSE (P31750) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto-oncogene) Length = 480 Score = 94.4 bits (233), Expect = 2e-19 Identities = 59/166 (35%), Positives = 94/166 (56%), Gaps = 2/166 (1%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 S +S +EE ++ + R +++F+ K LG+G FG V L +EK + A+K+L K Sbjct: 126 SDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV 185 Query: 272 L-KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH 448 + + +V H L E + + RHP + L F R+ ++E+A GEL+ L R + Sbjct: 186 IVAKDEVAHTL-TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV 244 Query: 449 FSERRSATYIASLARALIYLHG-KHVIHRDIKPENLLVGVQGELKI 583 FSE R+ Y A + AL YLH K+V++RD+K ENL++ G +KI Sbjct: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
>AKT1_HUMAN (P31749) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT) Length = 480 Score = 94.4 bits (233), Expect = 2e-19 Identities = 59/166 (35%), Positives = 94/166 (56%), Gaps = 2/166 (1%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 S +S +EE ++ + R +++F+ K LG+G FG V L +EK + A+K+L K Sbjct: 126 SDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV 185 Query: 272 L-KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH 448 + + +V H L E + + RHP + L F R+ ++E+A GEL+ L R + Sbjct: 186 IVAKDEVAHTL-TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV 244 Query: 449 FSERRSATYIASLARALIYLHG-KHVIHRDIKPENLLVGVQGELKI 583 FSE R+ Y A + AL YLH K+V++RD+K ENL++ G +KI Sbjct: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
>AKT1_BOVIN (Q01314) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (Protein kinase B) (PKB) Length = 480 Score = 94.4 bits (233), Expect = 2e-19 Identities = 58/164 (35%), Positives = 94/164 (57%), Gaps = 2/164 (1%) Frame = +2 Query: 98 DSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL- 274 +S +EE ++ + R +++F+ K LG+G FG V L +EK ++ A+K+L K + Sbjct: 128 NSGAEEMEVSLAKPKHRVTMNEFEYVKLLGKGTFGKVILVKEKATAAYYAMKILKKEVIV 187 Query: 275 KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFS 454 + +V H L E + + RHP++ L F R+ ++E+A GEL+ L R + FS Sbjct: 188 AKDEVAHTL-TENRVLQNSRHPSLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS 246 Query: 455 ERRSATYIASLARALIYLHG-KHVIHRDIKPENLLVGVQGELKI 583 E R+ Y A + AL YLH K V++RD+K ENL++ G +KI Sbjct: 247 EDRARFYGAEIVSALDYLHSEKEVVYRDLKLENLMLDKDGHIKI 290
>AKT_MLVAT (P31748) AKT kinase transforming protein (EC 2.7.11.1)| Length = 501 Score = 94.4 bits (233), Expect = 2e-19 Identities = 59/166 (35%), Positives = 94/166 (56%), Gaps = 2/166 (1%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 S +S +EE ++ + R +++F+ K LG+G FG V L +EK + A+K+L K Sbjct: 147 SDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV 206 Query: 272 L-KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH 448 + + +V H L E + + RHP + L F R+ ++E+A GEL+ L R + Sbjct: 207 IVAKDEVAHTL-TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV 265 Query: 449 FSERRSATYIASLARALIYLHG-KHVIHRDIKPENLLVGVQGELKI 583 FSE R+ Y A + AL YLH K+V++RD+K ENL++ G +KI Sbjct: 266 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 311
>AKT1_RAT (P47196) RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)| (RAC-PK-alpha) (Protein kinase B) (PKB) Length = 480 Score = 94.0 bits (232), Expect = 3e-19 Identities = 59/166 (35%), Positives = 94/166 (56%), Gaps = 2/166 (1%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 S +S +EE ++ + R +++F+ K LG+G FG V L +EK + A+K+L K Sbjct: 126 SDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV 185 Query: 272 L-KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH 448 + + +V H L E + + RHP + L F R+ ++E+A GEL+ L R + Sbjct: 186 IVAKDEVAHTL-TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV 244 Query: 449 FSERRSATYIASLARALIYLHG-KHVIHRDIKPENLLVGVQGELKI 583 FSE R+ Y A + AL YLH K+V++RD+K ENL++ G +KI Sbjct: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
>TSSK4_HUMAN (Q6SA08) Testis-specific serine/threonine-protein kinase 4 (EC| 2.7.11.1) (TSSK-4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E) Length = 328 Score = 94.0 bits (232), Expect = 3e-19 Identities = 48/141 (34%), Positives = 80/141 (56%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 ++VGKA+G G +G VY A + +VA+K++ K + + L RE+++ LRH Sbjct: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 ++ Y +RVY+ILE A G++ + +QR SE + + + L + YLH K + Sbjct: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144 Query: 524 IHRDIKPENLLVGVQGELKIA 586 +HRD+K ENLL+ +KI+ Sbjct: 145 VHRDLKLENLLLDKWENVKIS 165
>KRAC_DICDI (P54644) RAC-family serine/threonine-protein kinase homolog (EC| 2.7.11.1) Length = 444 Score = 94.0 bits (232), Expect = 3e-19 Identities = 53/142 (37%), Positives = 85/142 (59%), Gaps = 1/142 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 ++DF++ +G+G FG V R+K + + A+KVL K + + ++VEH L E I + Sbjct: 117 VADFELLNLVGKGSFGKVIQVRKKDTGEVYAMKVLSKKHIVEHNEVEHTLS-ERNILQKI 175 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 HP ++ L F + ++Y IL++ GEL+ LQ+ K F+E R Y A + AL +LH Sbjct: 176 NHPFLVNLNYSFQTEDKLYFILDYVNGGELFYHLQKDKKFTEDRVRYYGAEIVLALEHLH 235 Query: 512 GKHVIHRDIKPENLLVGVQGEL 577 VI+RD+KPENLL+ +G + Sbjct: 236 LSGVIYRDLKPENLLLTNEGHI 257
>AAPK2_CAEEL (Q95ZQ4) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMP-activated kinase 2) Length = 626 Score = 94.0 bits (232), Expect = 3e-19 Identities = 53/172 (30%), Positives = 94/172 (54%), Gaps = 7/172 (4%) Frame = +2 Query: 92 STDSRSE------EKPSQHSQEEKRWV-LSDFDVGKALGRGKFGHVYLAREKRSSHIVAL 250 STD+ S+ E ++ QE K + + + + + LG G FG V + + + + VA+ Sbjct: 56 STDNSSKMSSPGGETSTKQQQELKAQIKIGHYILKETLGVGTFGKVKVGIHETTQYKVAV 115 Query: 251 KVLFKSQLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKE 430 K+L + ++K V ++RRE++ S RHP+I+RLY + +++I+EH + GEL+ Sbjct: 116 KILNRQKIKSLDVVGKIRREIQNLSLFRHPHIIRLYQVISTPSDIFMIMEHVSGGELFDY 175 Query: 431 LQRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + + + + + + Y H V+HRD+KPENLL+ Q +KIA Sbjct: 176 IVKHGRLKTAEARRFFQQIISGVDYCHRHMVVHRDLKPENLLLDEQNNVKIA 227
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 94.0 bits (232), Expect = 3e-19 Identities = 54/147 (36%), Positives = 90/147 (61%), Gaps = 5/147 (3%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKR---SSHIVALKVLFKSQLKQSQVEHQLRREVE--IQ 322 S F++ K LG+G FG V+L R+ S H+ A+KVL K+ LK V ++R ++E I Sbjct: 60 SQFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK---VRDRVRTKMERDIL 116 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 + + HP +++L+ F + ++YLIL+ G+L+ L + F+E Y+A LA L Sbjct: 117 ADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLD 176 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKI 583 +LH +I+RD+KPEN+L+ +G +K+ Sbjct: 177 HLHSLGIIYRDLKPENILLDEEGHIKL 203 Score = 72.4 bits (176), Expect = 9e-13 Identities = 47/140 (33%), Positives = 76/140 (54%), Gaps = 2/140 (1%) Frame = +2 Query: 143 KRWVLSD-FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEI 319 K V SD + V + +G G + K ++ A+KV+ KS+ S+ E+EI Sbjct: 399 KNLVFSDGYVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSE-------EIEI 451 Query: 320 QSHL-RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARA 496 +HPNI+ L + D VYL+ E GEL ++ R K FSER ++ + ++++ Sbjct: 452 LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKT 511 Query: 497 LIYLHGKHVIHRDIKPENLL 556 + YLH + V+HRD+KP N+L Sbjct: 512 VEYLHSQGVVHRDLKPSNIL 531
>PCK1_SCHPO (P36582) Protein kinase C-like 1 (EC 2.7.11.13)| Length = 988 Score = 93.6 bits (231), Expect = 4e-19 Identities = 55/172 (31%), Positives = 92/172 (53%), Gaps = 3/172 (1%) Frame = +2 Query: 80 AMAISTDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVL 259 +++ S D+ S +++ R L DF LG+G FG V LA K + A+KVL Sbjct: 636 SLSSSKDANRSVPESPRREKKNRVTLDDFTFLAVLGKGNFGKVMLAEYKVNKKFYAIKVL 695 Query: 260 FKSQLKQSQVEHQLRRE---VEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKE 430 K + +++ L+ E E+ + +HP +L L+ F TRVY ++E+ G+L Sbjct: 696 KKEAILKNEELESLKTEKHVFEVANKEKHPFLLNLFASFQTSTRVYFVMEYILGGDLMVH 755 Query: 431 LQRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 +QR + FS +R+ Y A + AL Y H + +RD+K +N+L+ G ++IA Sbjct: 756 IQR-QQFSVKRARFYGAEVCLALKYFHENGIAYRDLKLDNILLCPDGHIRIA 806
>ST38L_HUMAN (Q9Y2H1) Serine/threonine-protein kinase 38-like (EC 2.7.11.1)| (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) Length = 464 Score = 93.6 bits (231), Expect = 4e-19 Identities = 52/171 (30%), Positives = 93/171 (54%), Gaps = 8/171 (4%) Frame = +2 Query: 98 DSRSEEKPSQHSQEEKRWV--------LSDFDVGKALGRGKFGHVYLAREKRSSHIVALK 253 D + + SQH+++E ++ L DF+ K +GRG FG V L ++K + HI A+K Sbjct: 60 DEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMK 119 Query: 254 VLFKSQLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKEL 433 +L KS + + + +R E +I +++++ F D+ +YLI+E G++ L Sbjct: 120 ILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLL 179 Query: 434 QRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + +E + YI+ A+ +H IHRDIKP+NLL+ +G +K++ Sbjct: 180 MKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLS 230
>CDPK2_MAIZE (P49101) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (CDPK 2)| Length = 513 Score = 93.6 bits (231), Expect = 4e-19 Identities = 51/142 (35%), Positives = 77/142 (54%), Gaps = 1/142 (0%) Frame = +2 Query: 152 VLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 V S + GK LGRG+FG YL E S A K + K +L +RRE++I HL Sbjct: 61 VRSVYSFGKELGRGQFGVTYLCTEIASGRQYACKSISKRKLVSKADREDIRREIQIMQHL 120 Query: 332 R-HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYL 508 PNI+ G + D++ V++++E A GEL+ + H++ER +AT ++ + Sbjct: 121 SGQPNIVEFRGAYEDKSNVHVVMELCAGGELFDRIIAKGHYTERAAATICRAVVNVVNIC 180 Query: 509 HGKHVIHRDIKPENLLVGVQGE 574 H V+HRD+KPEN L+ E Sbjct: 181 HFMGVMHRDLKPENFLLATMEE 202
>SCH9_YEAST (P11792) Serine/threonine-protein kinase SCH9 (EC 2.7.11.1)| Length = 823 Score = 93.6 bits (231), Expect = 4e-19 Identities = 55/156 (35%), Positives = 91/156 (58%), Gaps = 4/156 (2%) Frame = +2 Query: 128 HSQEEKR-WVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQL 301 + Q +KR + DF+V + LG+G FG VY ++K + I A+KVL K + K++++ H + Sbjct: 398 YKQTKKRHYGPQDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVKKNEIAHTI 457 Query: 302 --RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATY 475 R + + P I+ L F T +YL+ ++ + GEL+ LQ+ FSE R+ Y Sbjct: 458 GERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFY 517 Query: 476 IASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 IA L AL +LH +++RD+KPEN+L+ G + + Sbjct: 518 IAELVLALEHLHDNDIVYRDLKPENILLDANGNIAL 553
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 93.6 bits (231), Expect = 4e-19 Identities = 54/147 (36%), Positives = 90/147 (61%), Gaps = 5/147 (3%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKR---SSHIVALKVLFKSQLKQSQVEHQLRREVE--IQ 322 S F++ K LG+G FG V+L R+ S H+ A+KVL K+ LK V ++R ++E I Sbjct: 60 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK---VRDRVRTKMERDIL 116 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 + + HP +++L+ F + ++YLIL+ G+L+ L + F+E Y+A LA L Sbjct: 117 ADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLD 176 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKI 583 +LH +I+RD+KPEN+L+ +G +K+ Sbjct: 177 HLHSLGIIYRDLKPENILLDEEGHIKL 203 Score = 73.2 bits (178), Expect = 5e-13 Identities = 47/140 (33%), Positives = 75/140 (53%), Gaps = 2/140 (1%) Frame = +2 Query: 143 KRWVLSD-FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEI 319 K V SD + V + +G G + K ++ A+KV+ KS+ S+ E+EI Sbjct: 410 KNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-------EIEI 462 Query: 320 QSHL-RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARA 496 +HPNI+ L + D VYL+ E GEL ++ R K FSER ++ + ++ + Sbjct: 463 LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKT 522 Query: 497 LIYLHGKHVIHRDIKPENLL 556 + YLH + V+HRD+KP N+L Sbjct: 523 VEYLHSQGVVHRDLKPSNIL 542
>TSSK4_MOUSE (Q9D411) Testis-specific serine/threonine-protein kinase 4 (EC| 2.7.11.1) (TSSK-4) (Testis-specific kinase 4) (TSK-4) Length = 328 Score = 93.2 bits (230), Expect = 5e-19 Identities = 46/141 (32%), Positives = 82/141 (58%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 ++VGK +G G +G VY A + +VA+K++ K + + + L RE+++ LRH Sbjct: 25 YEVGKIIGHGSYGTVYEAYYTKQKVMVAVKIISKKKASEDYLNKFLPREIQVMKVLRHKY 84 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 ++ Y +RVY+ILE A G++ + +QR +E + + + +A + YLH K + Sbjct: 85 LINFYQAIETTSRVYIILELAQGGDVLEWIQRYGACAETLAGKWFSQMALGIAYLHSKGI 144 Query: 524 IHRDIKPENLLVGVQGELKIA 586 +HRD+K ENLL+ + +KI+ Sbjct: 145 VHRDLKLENLLLDKRENVKIS 165
>MARK3_MOUSE (Q03141) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| (MPK-10) (ELKL motif kinase 2) Length = 753 Score = 93.2 bits (230), Expect = 5e-19 Identities = 49/144 (34%), Positives = 83/144 (57%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + ++ + K +G+G F V LAR + VA+K++ K+QL + ++ +L REV I L Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI++L+ + +YLI+E+A+ GE++ L E+ + + A+ Y H Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 171 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 K ++HRD+K ENLL+ +KIA Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIA 195
>MARK1_HUMAN (Q9P0L2) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 795 Score = 93.2 bits (230), Expect = 5e-19 Identities = 48/144 (33%), Positives = 84/144 (58%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + ++ + K +G+G F V LAR + VA+K++ K+QL + ++ +L REV I L Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRIMKILN 115 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI++L+ + +YL++E+A+ GE++ L E+ + + A+ Y H Sbjct: 116 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 175 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 K+++HRD+K ENLL+ +KIA Sbjct: 176 KYIVHRDLKAENLLLDGDMNIKIA 199
>MARK2_RAT (O08679) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 722 Score = 93.2 bits (230), Expect = 5e-19 Identities = 49/144 (34%), Positives = 83/144 (57%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + ++ + K +G+G F V LAR + VA+K++ K+QL S ++ +L REV I L Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI++L+ + +YL++E+A+ GE++ L E+ + + A+ Y H Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 K ++HRD+K ENLL+ +KIA Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIA 192
>SN1L2_MOUSE (Q8CFH6) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Salt-inducible kinase 2) Length = 931 Score = 93.2 bits (230), Expect = 5e-19 Identities = 50/141 (35%), Positives = 81/141 (57%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 +D+ LG+G F V L R + + VA+K++ KSQL +E ++ REV+I L HP+ Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRTTKTEVAIKIIDKSQLDAVNLE-KIYREVQIMKMLDHPH 78 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I++LY ++ +YL+ E+A GE++ L +E + + A+ Y HG+ V Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKV 138 Query: 524 IHRDIKPENLLVGVQGELKIA 586 +HRD+K ENLL+ +KIA Sbjct: 139 VHRDLKAENLLLDNNMNIKIA 159
>MARK2_HUMAN (Q7KZI7) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog) Length = 788 Score = 93.2 bits (230), Expect = 5e-19 Identities = 49/144 (34%), Positives = 83/144 (57%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + ++ + K +G+G F V LAR + VA+K++ K+QL S ++ +L REV I L Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI++L+ + +YL++E+A+ GE++ L E+ + + A+ Y H Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 K ++HRD+K ENLL+ +KIA Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIA 192
>CDPK2_ORYSA (P53683) Calcium-dependent protein kinase, isoform 2 (EC 2.7.11.1)| (CDPK 2) Length = 533 Score = 92.8 bits (229), Expect = 6e-19 Identities = 51/142 (35%), Positives = 79/142 (55%), Gaps = 1/142 (0%) Frame = +2 Query: 152 VLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 V S + +GK LGRG+FG YL E S A K + K +L + +RRE++I HL Sbjct: 81 VRSVYSLGKELGRGQFGVTYLCTEIASGKQYACKSISKRKLVSKADKEDIRREIQIMQHL 140 Query: 332 R-HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYL 508 NI+ G + D++ V++++E A GEL+ + H+SER +AT ++ + Sbjct: 141 SGQQNIVEFRGAYEDKSNVHVVMELCAGGELFDRIIAKGHYSERAAATICRAVVNVVNIC 200 Query: 509 HGKHVIHRDIKPENLLVGVQGE 574 H V+HRD+KPEN L+ + E Sbjct: 201 HFMGVMHRDLKPENFLLATKEE 222
>ST32B_MOUSE (Q9JJX8) Serine/threonine-protein kinase 32B (EC 2.7.11.1)| Length = 414 Score = 92.8 bits (229), Expect = 6e-19 Identities = 50/161 (31%), Positives = 88/161 (54%) Frame = +2 Query: 101 SRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQ 280 + S + P EE + F + +A+G+G FG V + +++ + + A+K + K + + Sbjct: 4 NHSHKPPVFDENEEVNF--DHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCVE 61 Query: 281 SQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSER 460 + RE++I L HP ++ L+ F D+ ++++++ G+L LQ+ HF+E Sbjct: 62 RDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEG 121 Query: 461 RSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 YI LA AL YL H+IHRDIKP+N+L+ G + I Sbjct: 122 TVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHI 162
>CDC2_DICDI (P34112) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 296 Score = 92.4 bits (228), Expect = 8e-19 Identities = 50/144 (34%), Positives = 81/144 (56%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 LS + + LG G +G VY A+EK + +VALK K +L+ V RE+ + + Sbjct: 7 LSRYQKLEKLGEGTYGKVYKAKEKATGRMVALK---KIRLEDDGVPSTALREISLLKEVP 63 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPN++ L+ + Q R+YL+ E+ + +L K + + +Y+ L + L Y HG Sbjct: 64 HPNVVSLFDVLHCQNRLYLVFEYLDQ-DLKKYMDSVPALCPQLIKSYLYQLLKGLAYSHG 122 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 ++HRD+KP+NLL+ QG LK+A Sbjct: 123 HRILHRDLKPQNLLIDRQGALKLA 146
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 92.4 bits (228), Expect = 8e-19 Identities = 53/146 (36%), Positives = 89/146 (60%), Gaps = 4/146 (2%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLARE---KRSSHIVALKVLFKSQLK-QSQVEHQLRREVEIQS 325 SDF + K LG+G FG V+L R+ ++ + A+KVL K+ LK + +V ++ R++ Sbjct: 60 SDFVLLKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADV 119 Query: 326 HLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIY 505 H HP ++RL+ F + ++YLIL+ G+L+ L + F+E Y+A LA L + Sbjct: 120 H--HPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 177 Query: 506 LHGKHVIHRDIKPENLLVGVQGELKI 583 LH +I+RD+KPEN+L+ +G +K+ Sbjct: 178 LHSLGIIYRDLKPENILLDEEGHIKL 203 Score = 65.5 bits (158), Expect = 1e-10 Identities = 38/131 (29%), Positives = 70/131 (53%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 + V + +G G + K ++ A+KV+ K++ S+ LRR + +HPN Sbjct: 416 YTVRETIGVGSYSVCKRCVHKGTNMEYAVKVIDKTKRDPSEEIEILRR------YGQHPN 469 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I+ L + + +Y++ E GEL + R K FSER +++ + ++ + + LH + V Sbjct: 470 IIALKDVYKEGNSIYVVTELMRGGELLDRILRQKFFSEREASSVLFTVCKTVENLHSQGV 529 Query: 524 IHRDIKPENLL 556 +HRD+KP N+L Sbjct: 530 VHRDLKPSNIL 540
>MARK1_MOUSE (Q8VHJ5) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3) Length = 795 Score = 92.4 bits (228), Expect = 8e-19 Identities = 48/144 (33%), Positives = 83/144 (57%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + ++ + K +G+G F V LAR + VA+K++ K+QL + ++ +L REV I L Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRIMKILN 115 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI++L+ + +YL++E+A+ GE++ L E+ + + A+ Y H Sbjct: 116 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 175 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 K ++HRD+K ENLL+ +KIA Sbjct: 176 KCIVHRDLKAENLLLDADMNIKIA 199
>AKT1_DROME (Q8INB9) RAC serine/threonine-protein kinase (EC 2.7.11.1)| (DRAC-PK) (Akt) (Dakt1) (Protein kinase B) (PKB) Length = 611 Score = 92.4 bits (228), Expect = 8e-19 Identities = 59/171 (34%), Positives = 93/171 (54%), Gaps = 5/171 (2%) Frame = +2 Query: 89 ISTDSRSEEKPSQ----HSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKV 256 I+ D SE+ Q +S K+ L +F+ K LG+G FG V L REK ++ + A+K+ Sbjct: 237 IAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKI 296 Query: 257 LFKSQLKQS-QVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKEL 433 L K + Q +V H L E + HP ++ L F R+ ++++ GEL+ L Sbjct: 297 LKKEVIIQKDEVAHTLT-ESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHL 355 Query: 434 QRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + F+E R+ Y A + AL YLH + +I+RD+K ENLL+ G +K+A Sbjct: 356 SHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVA 406
>MARK1_RAT (O08678) Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 1) Length = 793 Score = 92.4 bits (228), Expect = 8e-19 Identities = 48/144 (33%), Positives = 83/144 (57%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + ++ + K +G+G F V LAR + VA+K++ K+QL + ++ +L REV I L Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRIMKILN 115 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI++L+ + +YL++E+A+ GE++ L E+ + + A+ Y H Sbjct: 116 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 175 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 K ++HRD+K ENLL+ +KIA Sbjct: 176 KCIVHRDLKAENLLLDADMNIKIA 199
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 92.4 bits (228), Expect = 8e-19 Identities = 53/147 (36%), Positives = 90/147 (61%), Gaps = 5/147 (3%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKR---SSHIVALKVLFKSQLKQSQVEHQLRREVE--IQ 322 S F++ K LG+G FG V+L R+ + H+ A+KVL K+ LK V ++R ++E I Sbjct: 60 SHFELLKVLGQGSFGKVFLVRKVTRPDNGHLYAMKVLKKATLK---VRDRVRTKMERDIL 116 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 + + HP +++L+ F + ++YLIL+ G+L+ L + F+E Y+A LA L Sbjct: 117 ADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLD 176 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKI 583 +LH +I+RD+KPEN+L+ +G +K+ Sbjct: 177 HLHSLGIIYRDLKPENILLDEEGHIKL 203 Score = 73.2 bits (178), Expect = 5e-13 Identities = 47/140 (33%), Positives = 76/140 (54%), Gaps = 2/140 (1%) Frame = +2 Query: 143 KRWVLSD-FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEI 319 K V SD + V + +G G + K ++ A+KV+ KS+ S+ E+EI Sbjct: 410 KNLVFSDGYIVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSE-------EIEI 462 Query: 320 QSHL-RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARA 496 +HPNI+ L + D VYL+ E GEL ++ R K FSER ++ + ++++ Sbjct: 463 LLRYGQHPNIITLKDVYDDSKHVYLVTELMRGGELLDKILRQKFFSEREASFVLYTISKT 522 Query: 497 LIYLHGKHVIHRDIKPENLL 556 + YLH + V+HRD+KP N+L Sbjct: 523 VEYLHSQGVVHRDLKPSNIL 542
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 92.4 bits (228), Expect = 8e-19 Identities = 52/146 (35%), Positives = 91/146 (62%), Gaps = 4/146 (2%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSS---HIVALKVLFKSQLK-QSQVEHQLRREVEIQS 325 S F++ K LG+G FG V+L ++ S + A+KVL K+ LK + +V ++ R++ ++ Sbjct: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE- 124 Query: 326 HLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIY 505 + HP I++L+ F + ++YLIL+ G+L+ L + F+E Y+A LA AL + Sbjct: 125 -VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 183 Query: 506 LHGKHVIHRDIKPENLLVGVQGELKI 583 LH +I+RD+KPEN+L+ +G +K+ Sbjct: 184 LHSLGIIYRDLKPENILLDEEGHIKL 209 Score = 68.6 bits (166), Expect = 1e-11 Identities = 40/132 (30%), Positives = 72/132 (54%), Gaps = 1/132 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL-RHP 340 ++V + +G G + K ++ A+K++ KS+ ++ E+EI +HP Sbjct: 422 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-------EIEILLRYGQHP 474 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKH 520 NI+ L + D VY++ E GEL ++ R K FSER ++ + ++ + + YLH + Sbjct: 475 NIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQG 534 Query: 521 VIHRDIKPENLL 556 V+HRD+KP N+L Sbjct: 535 VVHRDLKPSNIL 546
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 92.4 bits (228), Expect = 8e-19 Identities = 52/146 (35%), Positives = 91/146 (62%), Gaps = 4/146 (2%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSS---HIVALKVLFKSQLK-QSQVEHQLRREVEIQS 325 S F++ K LG+G FG V+L ++ S + A+KVL K+ LK + +V ++ R++ ++ Sbjct: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE- 124 Query: 326 HLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIY 505 + HP I++L+ F + ++YLIL+ G+L+ L + F+E Y+A LA AL + Sbjct: 125 -VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 183 Query: 506 LHGKHVIHRDIKPENLLVGVQGELKI 583 LH +I+RD+KPEN+L+ +G +K+ Sbjct: 184 LHSLGIIYRDLKPENILLDEEGHIKL 209 Score = 68.6 bits (166), Expect = 1e-11 Identities = 40/132 (30%), Positives = 72/132 (54%), Gaps = 1/132 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL-RHP 340 ++V + +G G + K ++ A+K++ KS+ ++ E+EI +HP Sbjct: 422 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-------EIEILLRYGQHP 474 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKH 520 NI+ L + D VY++ E GEL ++ R K FSER ++ + ++ + + YLH + Sbjct: 475 NIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQG 534 Query: 521 VIHRDIKPENLL 556 V+HRD+KP N+L Sbjct: 535 VVHRDLKPSNIL 546
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 92.4 bits (228), Expect = 8e-19 Identities = 50/143 (34%), Positives = 82/143 (57%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + + V + +G G FG VY R K S+ +VALK + K + ++ + L+RE+EI LR Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRN-LQREIEIMRGLR 59 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI+ + F V ++ ++A +GEL++ L+ E + A L AL YLH Sbjct: 60 HPNIVHMLDSFETDKEVVVVTDYA-EGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHS 118 Query: 515 KHVIHRDIKPENLLVGVQGELKI 583 ++HRD+KP+N+L+ G +K+ Sbjct: 119 HRILHRDMKPQNILLAKGGGIKL 141
>ST32B_HUMAN (Q9NY57) Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2)| Length = 414 Score = 92.4 bits (228), Expect = 8e-19 Identities = 50/161 (31%), Positives = 88/161 (54%) Frame = +2 Query: 101 SRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQ 280 + S + P EE + F + +A+G+G FG V + +++ + + A+K + K + + Sbjct: 4 NHSHKPPVFDENEEVNF--DHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIE 61 Query: 281 SQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSER 460 + RE++I L HP ++ L+ F D+ ++++++ G+L LQ+ HF+E Sbjct: 62 RDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEG 121 Query: 461 RSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 YI LA AL YL H+IHRDIKP+N+L+ G + I Sbjct: 122 TVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHI 162
>KPC1_ASPNG (Q00078) Protein kinase C-like (EC 2.7.11.13)| Length = 1096 Score = 92.0 bits (227), Expect = 1e-18 Identities = 54/163 (33%), Positives = 88/163 (53%), Gaps = 3/163 (1%) Frame = +2 Query: 107 SEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQ 286 S++ P Q + R L F+ LG+G FG V LA K + + A+KVL K + ++ Sbjct: 752 SQQPPEAPQQPKVRIGLDHFNFLAVLGKGNFGKVMLAETKSTKRLYAIKVLKKEFIIEND 811 Query: 287 VEHQLRREVE---IQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSE 457 + E I + RHP +L L+ F +TRVY ++E+ + G+L +QR F Sbjct: 812 EVESTKSEKRVFMIANKERHPFLLNLHACFQTETRVYFVMEYISGGDLMLHIQR-GQFGL 870 Query: 458 RRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 +R+ Y A + AL Y H VI+RD+K +N+++ + G +K+A Sbjct: 871 KRAQFYAAEVLLALKYFHENGVIYRDLKLDNIMLTLDGHIKVA 913
>SN1L2_PONPY (Q5REX1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) Length = 925 Score = 92.0 bits (227), Expect = 1e-18 Identities = 49/141 (34%), Positives = 81/141 (57%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 +D+ LG+G F V L R + + VA+K++ KSQL +E ++ REV+I L HP+ Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLE-KIYREVQIMKMLDHPH 78 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I++LY ++ +YL+ E+A GE++ L +E + + A+ Y HG+ + Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138 Query: 524 IHRDIKPENLLVGVQGELKIA 586 +HRD+K ENLL+ +KIA Sbjct: 139 VHRDLKAENLLLDNNMNIKIA 159
>KAPC_ENCCU (Q8SRK8) Probable cAMP-dependent protein kinase catalytic subunit| (EC 2.7.11.11) Length = 322 Score = 92.0 bits (227), Expect = 1e-18 Identities = 48/145 (33%), Positives = 86/145 (59%), Gaps = 2/145 (1%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRS-SHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 + DF+ K +G G FG V+L R K S + + A+K+L ++ + ++ QL E+ I + Sbjct: 4 IQDFEFVKVVGVGAFGKVHLVRLKSSPTSVFAMKMLDFGEILRQRLADQLENEISILKRI 63 Query: 332 RH-PNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYL 508 P + +LY + +V LI+E+ GEL+ L++C F E+ + Y A + AL ++ Sbjct: 64 YGCPFVAKLYSTDFHGGKVGLIMEYVGGGELFYWLKKCGRFDEQMARFYAAEIISALRFI 123 Query: 509 HGKHVIHRDIKPENLLVGVQGELKI 583 HG+ +++RD+KPEN+L+ G +K+ Sbjct: 124 HGRGILYRDLKPENILITSTGHIKL 148
>SN1L2_HUMAN (Q9H0K1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 926 Score = 92.0 bits (227), Expect = 1e-18 Identities = 49/141 (34%), Positives = 81/141 (57%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 +D+ LG+G F V L R + + VA+K++ KSQL +E ++ REV+I L HP+ Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLE-KIYREVQIMKMLDHPH 78 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I++LY ++ +YL+ E+A GE++ L +E + + A+ Y HG+ + Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138 Query: 524 IHRDIKPENLLVGVQGELKIA 586 +HRD+K ENLL+ +KIA Sbjct: 139 VHRDLKAENLLLDNNMNIKIA 159
>KPC1_TRIRE (Q99014) Protein kinase C-like (EC 2.7.11.13)| Length = 1139 Score = 91.7 bits (226), Expect = 1e-18 Identities = 52/147 (35%), Positives = 83/147 (56%), Gaps = 3/147 (2%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVE---IQS 325 L F+ LG+G FG V LA KRS + A+KVL K + ++ ++ E I + Sbjct: 811 LDHFNFLAVLGKGNFGKVMLAETKRSKRLFAIKVLKKEFIIENDEVESIKSEKRVFLIAN 870 Query: 326 HLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIY 505 RHP + L+ F +TRVY ++E+ + G+L +QR + F +R+ Y A + AL Y Sbjct: 871 RERHPFLTNLHACFQTETRVYFVMEYISGGDLMLHIQRGQ-FGTKRAQFYAAEVCLALKY 929 Query: 506 LHGKHVIHRDIKPENLLVGVQGELKIA 586 H VI+RD+K +N+++ + G +KIA Sbjct: 930 FHENGVIYRDLKLDNIMLTLDGHIKIA 956
>MARK3_RAT (Q8VHF0) MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1)| Length = 797 Score = 91.7 bits (226), Expect = 1e-18 Identities = 48/143 (33%), Positives = 82/143 (57%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + ++ + K +G+G F V LAR + VA+K++ K+QL + ++ +L REV I L Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI++L+ + +YLI+E+A+ GE++ L E+ + + A+ Y H Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 171 Query: 515 KHVIHRDIKPENLLVGVQGELKI 583 K ++HRD+K ENLL+ +KI Sbjct: 172 KRIVHRDLKAENLLLDADMNIKI 194
>MASTL_HUMAN (Q96GX5) Microtubule-associated serine/threonine-protein| kinase-like (EC 2.7.11.1) Length = 879 Score = 91.3 bits (225), Expect = 2e-18 Identities = 46/143 (32%), Positives = 81/143 (56%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + +F + K + RG FG VYL + + + A+KV+ K+ + + HQ++ E + + + Sbjct: 32 IEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSK 89 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 P I+ LY VYL++E+ G++ L +F E + YI+ +A AL YLH Sbjct: 90 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHR 149 Query: 515 KHVIHRDIKPENLLVGVQGELKI 583 +IHRD+KP+N+L+ +G +K+ Sbjct: 150 HGIIHRDLKPDNMLISNEGHIKL 172
>SNRK_HUMAN (Q9NRH2) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 765 Score = 91.3 bits (225), Expect = 2e-18 Identities = 51/132 (38%), Positives = 78/132 (59%), Gaps = 1/132 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 +D+ K LGRG F V LAR + VA+KV+ K++L H L +EV ++HPN Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGH-LFQEVRCMKLVQHPN 74 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH-FSERRSATYIASLARALIYLHGKH 520 I+RLY QT++YLILE G+++ + + + +E + Y A + A+ Y H H Sbjct: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134 Query: 521 VIHRDIKPENLL 556 V+HRD+KPEN++ Sbjct: 135 VVHRDLKPENVV 146
>ST32C_HUMAN (Q86UX6) Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE)| (YANK3) Length = 486 Score = 91.3 bits (225), Expect = 2e-18 Identities = 48/163 (29%), Positives = 90/163 (55%) Frame = +2 Query: 83 MAISTDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLF 262 M S + + +P +E+ + F + +A+G+G FG V + +++ + + A+K + Sbjct: 68 MGSSMSAATARRPVFDDKEDVNF--DHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMN 125 Query: 263 KSQLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRC 442 K Q + + RE+EI + H ++ L+ F D+ ++++++ G+L LQ+ Sbjct: 126 KQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN 185 Query: 443 KHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQG 571 FSE YI +A AL YL G+H+IHRD+KP+N+L+ +G Sbjct: 186 VQFSEDTVRLYICEMALALDYLRGQHIIHRDVKPDNILLDERG 228
>SNRK_RAT (Q63553) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 746 Score = 91.3 bits (225), Expect = 2e-18 Identities = 51/132 (38%), Positives = 78/132 (59%), Gaps = 1/132 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 +D+ K LGRG F V LAR + VA+KV+ K++L H L +EV ++HPN Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGH-LFQEVRCMKLVQHPN 74 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH-FSERRSATYIASLARALIYLHGKH 520 I+RLY QT++YLILE G+++ + + + +E + Y A + A+ Y H H Sbjct: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134 Query: 521 VIHRDIKPENLL 556 V+HRD+KPEN++ Sbjct: 135 VVHRDLKPENVV 146
>PKH3_ASHGO (Q753D9) Serine/threonine-protein kinase PKH3 (EC 2.7.11.1)| Length = 726 Score = 91.3 bits (225), Expect = 2e-18 Identities = 52/151 (34%), Positives = 84/151 (55%), Gaps = 3/151 (1%) Frame = +2 Query: 143 KRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQL--RREV 313 KR DF + LG G + VY E+ S H A+K+ K + +++V++ + + Sbjct: 3 KRKSPHDFLFREELGHGSYSTVYRVVERSSQHQYAIKICSKRHIIGENKVKYVTIEKNTL 62 Query: 314 EIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLAR 493 + HP I++LY F+DQ +Y +++ A GEL + L+R + FSE + Y+ L Sbjct: 63 NLLGQANHPGIIKLYYTFHDQENLYFVMDLAPGGELLQLLRRQRVFSEAWARHYMCQLVD 122 Query: 494 ALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + Y+H VIHRD+KPEN+L+ +G L IA Sbjct: 123 TVEYIHSMGVIHRDLKPENVLLDKEGRLMIA 153
>SNRK_MOUSE (Q8VDU5) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 748 Score = 91.3 bits (225), Expect = 2e-18 Identities = 51/132 (38%), Positives = 78/132 (59%), Gaps = 1/132 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 +D+ K LGRG F V LAR + VA+KV+ K++L H L +EV ++HPN Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGH-LFQEVRCMKLVQHPN 74 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH-FSERRSATYIASLARALIYLHGKH 520 I+RLY QT++YLILE G+++ + + + +E + Y A + A+ Y H H Sbjct: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134 Query: 521 VIHRDIKPENLL 556 V+HRD+KPEN++ Sbjct: 135 VVHRDLKPENVV 146
>PRKX_MOUSE (Q922R0) Serine/threonine-protein kinase PRKX (EC 2.7.11.1)| (PKA-related protein kinase) Length = 355 Score = 91.3 bits (225), Expect = 2e-18 Identities = 48/159 (30%), Positives = 84/159 (52%) Frame = +2 Query: 107 SEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQ 286 ++ KP SQ+ L D+D +G G FG V L +EK ALK++ + + + Sbjct: 28 ADPKPRTSSQKAGH-SLQDWDTIATVGTGTFGRVNLVKEKTGRQYCALKIMSIPDVIRLK 86 Query: 287 VEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRS 466 E ++ E + + HP +++L +D +Y+++E GEL+ L+ FS S Sbjct: 87 QEQHVQNEKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVAS 146 Query: 467 ATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 Y + A+ YLH K +++RD+KPEN+L+ +G +K+ Sbjct: 147 VFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKL 185
>ST32C_MOUSE (Q8QZV4) Serine/threonine-protein kinase 32C (EC 2.7.11.1)| Length = 488 Score = 91.3 bits (225), Expect = 2e-18 Identities = 49/160 (30%), Positives = 88/160 (55%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 S S S +P +E+ + F + +A+G+G FG V + +++ + + A+K + K Q Sbjct: 72 SISSGSARRPVFDDKEDVNF--DHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQ 129 Query: 272 LKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHF 451 + + RE+EI + H ++ L+ F D+ ++++++ G+L LQ+ F Sbjct: 130 CIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQF 189 Query: 452 SERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQG 571 SE YI +A AL YL +H+IHRD+KP+N+L+ QG Sbjct: 190 SEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQG 229
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 90.9 bits (224), Expect = 2e-18 Identities = 49/140 (35%), Positives = 77/140 (55%) Frame = +2 Query: 140 EKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEI 319 E +L + +GK +G G F V ++ + ALK++ K+ K EH + EV I Sbjct: 386 ESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKA--KCCGKEHLIENEVSI 443 Query: 320 QSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARAL 499 ++HPNI+ L T ++L++E G+L+ + ++ER + + +LA AL Sbjct: 444 LRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANAL 503 Query: 500 IYLHGKHVIHRDIKPENLLV 559 YLHG ++HRDIKPENLLV Sbjct: 504 RYLHGLSIVHRDIKPENLLV 523
>KAD5_SCHPO (Q09831) Probable serine/threonine-protein kinase C4G8.05 (EC| 2.7.11.1) Length = 566 Score = 90.9 bits (224), Expect = 2e-18 Identities = 53/145 (36%), Positives = 78/145 (53%), Gaps = 2/145 (1%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRH 337 S F+ LG+G G VYL REK+S A+KVL K ++ + + E I + H Sbjct: 193 SSFEKVFLLGKGDVGRVYLVREKKSGKFYAMKVLSKQEMIKRNKSKRAFAEQHILATSNH 252 Query: 338 PNILRLYGYFYDQTRVYLILEHAAKGELYKELQR--CKHFSERRSATYIASLARALIYLH 511 P I+ LY F +YL +E+ GE ++ LQR + SE + YIA + AL YLH Sbjct: 253 PFIVTLYHSFQSDEYLYLCMEYCMGGEFFRALQRRPGRCLSENEAKFYIAEVTAALEYLH 312 Query: 512 GKHVIHRDIKPENLLVGVQGELKIA 586 I+RD+KPEN+L+ G + ++ Sbjct: 313 LMGFIYRDLKPENILLHESGHIMLS 337
>MASTL_MOUSE (Q8C0P0) Microtubule-associated serine/threonine-protein| kinase-like (EC 2.7.11.1) Length = 865 Score = 90.9 bits (224), Expect = 2e-18 Identities = 45/143 (31%), Positives = 82/143 (57%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + +F + K + RG FG VYL + + + A+KV+ K+ + + HQ++ E + + + Sbjct: 31 IEEFTIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMVNKNMTHQVQAERDALALSK 88 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 P ++ LY + +YLI+E+ G++ L +F E + YI+ +A AL YLH Sbjct: 89 SPFVVHLYYSLQSASNIYLIMEYLIGGDVKSLLHIYGYFDEEMAIKYISEVALALDYLHR 148 Query: 515 KHVIHRDIKPENLLVGVQGELKI 583 +IHRD+KP+N+L+ +G +K+ Sbjct: 149 HGIIHRDLKPDNMLISNEGHIKL 171
>KPC1_NEUCR (P87253) Protein kinase C-like (EC 2.7.11.13)| Length = 1142 Score = 90.9 bits (224), Expect = 2e-18 Identities = 53/147 (36%), Positives = 82/147 (55%), Gaps = 3/147 (2%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVE---IQS 325 L F+ LG+G FG V LA K+S + A+KVL K + ++ +R E I + Sbjct: 814 LDHFNFLAVLGKGNFGKVMLAETKKSRKLYAIKVLKKEFIIENDEVESIRSEKRVFLIAN 873 Query: 326 HLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIY 505 RHP + L+ F +TRVY ++E+ + G+L +QR F +R+ Y A + AL Y Sbjct: 874 RERHPFLTNLHACFQTETRVYFVMEYISGGDLMLHIQRGM-FGTKRAQFYAAEVCLALKY 932 Query: 506 LHGKHVIHRDIKPENLLVGVQGELKIA 586 H VI+RD+K +N+L+ + G +KIA Sbjct: 933 FHENGVIYRDLKLDNILLTLDGHIKIA 959
>KPC1_COCHE (O42632) Protein kinase C-like (EC 2.7.11.13)| Length = 1174 Score = 90.9 bits (224), Expect = 2e-18 Identities = 53/151 (35%), Positives = 84/151 (55%), Gaps = 3/151 (1%) Frame = +2 Query: 143 KRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVE-- 316 KR L F+ LG+G FG V LA K + + A+KVL K + ++ R E Sbjct: 842 KRIGLDHFNFLAVLGKGNFGKVMLAETKTTKQLYAIKVLKKEFIIENDEVESTRSEKRVF 901 Query: 317 -IQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLAR 493 I + RHP +L L+ F +TRVY ++E+ + G+L +QR + F +R+ Y A + Sbjct: 902 LIANKERHPFLLNLHACFQTETRVYFVMEYISGGDLMLHIQRGQ-FGTKRAQFYAAEVCL 960 Query: 494 ALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 AL Y H VI+RD+K +N+++ + G +K+A Sbjct: 961 ALKYFHENGVIYRDLKLDNIMLTLDGHIKVA 991
>SNF1_YEAST (P06782) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 633 Score = 90.9 bits (224), Expect = 2e-18 Identities = 46/144 (31%), Positives = 81/144 (56%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + ++ + K LG G FG V LA + VALK++ K L +S ++ ++ RE+ LR Sbjct: 52 IGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLR 111 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP+I++LY + + +++E+A EL+ + + SE+ + + + A+ Y H Sbjct: 112 HPHIIKLYDVIKSKDEIIMVIEYAG-NELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 170 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 ++HRD+KPENLL+ +KIA Sbjct: 171 HKIVHRDLKPENLLLDEHLNVKIA 194
>PCK2_SCHPO (P36583) Protein kinase C-like 2 (EC 2.7.11.13)| Length = 1016 Score = 90.9 bits (224), Expect = 2e-18 Identities = 50/155 (32%), Positives = 84/155 (54%), Gaps = 3/155 (1%) Frame = +2 Query: 131 SQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRRE 310 + + KR L DF LG+G FG V LA K + A+KVL K + ++ + E Sbjct: 672 THKAKRIGLEDFTFLSVLGKGNFGKVMLAELKSEKQLYAIKVLKKEFILENDEVESTKSE 731 Query: 311 VEI---QSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIA 481 + + RHP ++ L+ F +TR+Y +++ + G+L +Q+ + FS RR+ Y A Sbjct: 732 KRVFLVANRERHPFLVNLHSCFQTETRIYFVMDFVSGGDLMLHIQQ-EQFSRRRAQFYAA 790 Query: 482 SLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + AL Y H +I+RD+K +N+L+ G +K+A Sbjct: 791 EVCLALKYFHDNGIIYRDLKLDNILLSPDGHVKVA 825
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 90.9 bits (224), Expect = 2e-18 Identities = 50/143 (34%), Positives = 81/143 (56%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + + V + +G G FG VY R K S+ +VALK + K + ++ + L+RE+EI LR Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRN-LQREIEIMRGLR 59 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI+ + F V ++ ++A +GEL + L+ E + A L AL YLH Sbjct: 60 HPNIVHMLDSFETDKEVVVVTDYA-EGELLQILEDDGKLPEDQVQAIAAQLVSALYYLHS 118 Query: 515 KHVIHRDIKPENLLVGVQGELKI 583 ++HRD+KP+N+L+ G +K+ Sbjct: 119 HRILHRDMKPQNILLAKGGGIKL 141
>PK2_DICDI (P28178) Protein kinase 2 (EC 2.7.11.1)| Length = 479 Score = 90.5 bits (223), Expect = 3e-18 Identities = 48/151 (31%), Positives = 84/151 (55%) Frame = +2 Query: 131 SQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRRE 310 S+ ++ DF++ +G+G FG V ++K I A+KVL K + + + + E Sbjct: 142 SKNKQSATKDDFELLNVIGKGSFGKVMQVKKKGEDKIFAMKVLRKDAIIARKQVNHTKSE 201 Query: 311 VEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLA 490 I + HP I+ L+ F + ++Y++L+ GEL+ L+R FSE R Y A + Sbjct: 202 KTILQCISHPFIVNLHYAFQTKDKLYMVLDFVNGGELFFHLKREGRFSEPRVKIYAAEIV 261 Query: 491 RALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 AL +LH + +++RD+KPEN+L+ +G + I Sbjct: 262 SALDHLHKQDIVYRDLKPENILLDSEGHICI 292
>MARK2_MOUSE (Q05512) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 776 Score = 90.5 bits (223), Expect = 3e-18 Identities = 48/144 (33%), Positives = 82/144 (56%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + ++ + K +G+G F V LAR + VA+K++ K+QL S ++ +L REV I L Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI++L+ + +YL++E+A+ GE++ L E+ + + + Y H Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVLHVQYCHQ 168 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 K ++HRD+K ENLL+ +KIA Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIA 192
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 90.5 bits (223), Expect = 3e-18 Identities = 52/155 (33%), Positives = 85/155 (54%), Gaps = 1/155 (0%) Frame = +2 Query: 95 TDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL 274 T+ SE K + H Q + GK LG G FG V A+ + VA+K+L K L Sbjct: 15 TEEDSEGKMA-HVQPASYVNKKKYVFGKTLGAGTFGVVRQAKNTETGEDVAVKILIKKAL 73 Query: 275 KQSQVEHQ-LRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHF 451 K ++V+ + L E++I L HPNI+ +F + + Y+I + A GEL+ + + F Sbjct: 74 KGNKVQLEALYDELDILQRLHHPNIVAFKDWFESKDKFYIITQLAKGGELFDRILKKGKF 133 Query: 452 SERRSATYIASLARALIYLHGKHVIHRDIKPENLL 556 +E + + + A+ Y+H ++++HRD+KPENLL Sbjct: 134 TEEDAVRILVEILSAVKYMHSQNIVHRDLKPENLL 168
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 90.5 bits (223), Expect = 3e-18 Identities = 46/144 (31%), Positives = 81/144 (56%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + ++ + K LG G FG V LA + VALK++ K L +S ++ ++ RE+ LR Sbjct: 36 VGNYQIVKTLGEGSFGKVKLAYHVTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLR 95 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP+I++LY + + +++E+A EL+ + + SE+ + + + A+ Y H Sbjct: 96 HPHIIKLYDVIKSKDEIIMVIEYAG-NELFDYIVQRNKMSEQEARRFFQQIISAVEYCHR 154 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 ++HRD+KPENLL+ +KIA Sbjct: 155 HKIVHRDLKPENLLLDEHLNVKIA 178
>DCAK1_HUMAN (O15075) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 740 Score = 90.5 bits (223), Expect = 3e-18 Identities = 49/149 (32%), Positives = 84/149 (56%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVE 292 E+ S+ + + + VG+ +G G F V E+ ++ ALK++ KS+ + E Sbjct: 373 EEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGK--E 430 Query: 293 HQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSAT 472 H ++ EV I ++HPNI+ L T +YL++E G+L+ + ++ER ++ Sbjct: 431 HMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASG 490 Query: 473 YIASLARALIYLHGKHVIHRDIKPENLLV 559 + +LA A+ YLH +++HRDIKPENLLV Sbjct: 491 MLYNLASAIKYLHSLNIVHRDIKPENLLV 519
>KCC4_RAT (P13234) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) (Calspermin) Length = 474 Score = 90.5 bits (223), Expect = 3e-18 Identities = 61/168 (36%), Positives = 85/168 (50%), Gaps = 4/168 (2%) Frame = +2 Query: 95 TDSRSEEKPSQHSQEEKRWVLSDF-DVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ 271 T S P KR LSDF +V LGRG VY ++K + ALKVL K+ Sbjct: 18 TSSTENLVPDYWIDGSKRDPLSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV 77 Query: 272 LKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHF 451 K+ +R E+ + L HPNI++L F T + L+LE GEL+ + ++ Sbjct: 78 DKKI-----VRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYY 132 Query: 452 SERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGV---QGELKIA 586 SER +A + + A+ YLH ++HRD+KPENLL LKIA Sbjct: 133 SERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIA 180
>CBK1_ASHGO (Q754N7) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 719 Score = 90.1 bits (222), Expect = 4e-18 Identities = 52/148 (35%), Positives = 86/148 (58%), Gaps = 1/148 (0%) Frame = +2 Query: 146 RWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQ 322 R L DF K +G+G FG V L ++K + I A+K L KS++ K+ Q+ H ++ E ++ Sbjct: 304 RLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAH-VKAERDVL 362 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 + P ++ LY F D +YLI+E G+L L R + F+E + Y+A A+ Sbjct: 363 AGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQIFTEDVTRFYMAECILAIE 422 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKIA 586 +H IHRDIKP+N+L+ ++G +K++ Sbjct: 423 AIHKLGFIHRDIKPDNILIDIRGHIKLS 450
>CBK1_YEAST (P53894) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1) (Cell| wall biosynthesis kinase) Length = 756 Score = 90.1 bits (222), Expect = 4e-18 Identities = 52/148 (35%), Positives = 86/148 (58%), Gaps = 1/148 (0%) Frame = +2 Query: 146 RWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQ 322 R L DF K +G+G FG V L ++K + I A+K L KS++ K+ Q+ H ++ E ++ Sbjct: 346 RLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAH-VKAERDVL 404 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 + P ++ LY F D +YLI+E G+L L R + F+E + Y+A A+ Sbjct: 405 AGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIE 464 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKIA 586 +H IHRDIKP+N+L+ ++G +K++ Sbjct: 465 TIHKLGFIHRDIKPDNILIDIRGHIKLS 492
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1)| (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 90.1 bits (222), Expect = 4e-18 Identities = 50/146 (34%), Positives = 91/146 (62%), Gaps = 4/146 (2%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKR---SSHIVALKVLFKSQLK-QSQVEHQLRREVEIQS 325 + F++ K LG+G FG V+L R+K + + A+KVL K+ LK + +V ++ R++ ++ Sbjct: 71 AQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVE- 129 Query: 326 HLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIY 505 + HP I++L+ F + ++YLIL+ G+++ L + F+E Y+A LA AL + Sbjct: 130 -VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDH 188 Query: 506 LHGKHVIHRDIKPENLLVGVQGELKI 583 LH +++RD+KPEN+L+ G +K+ Sbjct: 189 LHQLGIVYRDLKPENILLDEIGHIKL 214 Score = 65.1 bits (157), Expect = 1e-10 Identities = 45/137 (32%), Positives = 71/137 (51%), Gaps = 16/137 (11%) Frame = +2 Query: 194 KFGHVYLARE----------KRSSHIV-----ALKVLFKSQLKQSQVEHQLRREVEI-QS 325 +FG VY +E KR H A+K++ KS+ S+ E+EI Sbjct: 421 QFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSE-------EIEILMR 473 Query: 326 HLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIY 505 + +HPNI+ L F D VYL+ + GEL + + K FSER ++ + +++ + Y Sbjct: 474 YGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDY 533 Query: 506 LHGKHVIHRDIKPENLL 556 LH + V+HRD+KP N+L Sbjct: 534 LHCQGVVHRDLKPSNIL 550
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 90.1 bits (222), Expect = 4e-18 Identities = 43/155 (27%), Positives = 85/155 (54%) Frame = +2 Query: 122 SQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQL 301 ++ + + R + + +G LG G FG V + + + + H VA+K+L + +++ V ++ Sbjct: 4 AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 63 Query: 302 RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIA 481 RRE++ RHP+I++LY + +++++E+ + GEL+ + + E+ S Sbjct: 64 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 123 Query: 482 SLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + + Y H V+HRD+KPEN+L+ KIA Sbjct: 124 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIA 158
>CDPK1_ARATH (Q06850) Calcium-dependent protein kinase, isoform AK1 (EC| 2.7.11.1) (CDPK) Length = 610 Score = 90.1 bits (222), Expect = 4e-18 Identities = 45/132 (34%), Positives = 77/132 (58%), Gaps = 1/132 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR-HP 340 + +G+ LG+G+FG +L EK + A K + K +L + +RRE++I HL HP Sbjct: 150 YSLGRKLGQGQFGTTFLCVEKTTGKEFACKSIAKRKLLTDEDVEDVRREIQIMHHLAGHP 209 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKH 520 N++ + G + D V+L++E A GEL+ + + H++ER++A ++ + H Sbjct: 210 NVISIKGAYEDVVAVHLVMECCAGGELFDRIIQRGHYTERKAAELTRTIVGVVEACHSLG 269 Query: 521 VIHRDIKPENLL 556 V+HRD+KPEN L Sbjct: 270 VMHRDLKPENFL 281
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 90.1 bits (222), Expect = 4e-18 Identities = 47/157 (29%), Positives = 86/157 (54%), Gaps = 2/157 (1%) Frame = +2 Query: 122 SQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQL 301 ++ + + R + + +G LG G FG V + + + H VA+K+L + +++ V ++ Sbjct: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 Query: 302 RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH--FSERRSATY 475 +RE++ RHP+I++LY T ++++E+ + GEL+ + CKH E + Sbjct: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRL 119 Query: 476 IASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + A+ Y H V+HRD+KPEN+L+ Q KIA Sbjct: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIA 156
>SRK1_SCHPO (O94547) Serine/threonine-protein kinase srk1 (EC 2.7.11.1)| (Sty1-regulated kinase 1) Length = 580 Score = 90.1 bits (222), Expect = 4e-18 Identities = 53/144 (36%), Positives = 80/144 (55%), Gaps = 10/144 (6%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ---------LKQSQVEHQLRR 307 L + + + +G G F +VY A R+ VA+KV+ ++Q +Q H + + Sbjct: 121 LEQYTLLQKMGDGAFSNVYKAIHNRTGEKVAIKVVQRAQPNTDPRDPRKRQGVESHNILK 180 Query: 308 EVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASL 487 EV+I ++HPNI++L + YL+LE A GEL+ ++ R +FSE S I + Sbjct: 181 EVQIMRRVKHPNIIQLLEFIQTPEYYYLVLELADGGELFHQIVRLTYFSEDLSRHVITQV 240 Query: 488 ARALIYLHGK-HVIHRDIKPENLL 556 A A+ YLH V+HRDIKPENLL Sbjct: 241 AHAIRYLHEDCGVVHRDIKPENLL 264
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 90.1 bits (222), Expect = 4e-18 Identities = 43/155 (27%), Positives = 85/155 (54%) Frame = +2 Query: 122 SQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQL 301 ++ + + R + + +G LG G FG V + + + + H VA+K+L + +++ V ++ Sbjct: 2 AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 61 Query: 302 RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIA 481 RRE++ RHP+I++LY + +++++E+ + GEL+ + + E+ S Sbjct: 62 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 121 Query: 482 SLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + + Y H V+HRD+KPEN+L+ KIA Sbjct: 122 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIA 156
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 90.1 bits (222), Expect = 4e-18 Identities = 43/155 (27%), Positives = 85/155 (54%) Frame = +2 Query: 122 SQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQL 301 ++ + + R + + +G LG G FG V + + + + H VA+K+L + +++ V ++ Sbjct: 2 AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 61 Query: 302 RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIA 481 RRE++ RHP+I++LY + +++++E+ + GEL+ + + E+ S Sbjct: 62 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 121 Query: 482 SLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + + Y H V+HRD+KPEN+L+ KIA Sbjct: 122 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIA 156
>DCAK1_RAT (O08875) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) Length = 433 Score = 90.1 bits (222), Expect = 4e-18 Identities = 49/149 (32%), Positives = 83/149 (55%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVE 292 E+ S + + + VG+ +G G F V E+ ++ ALK++ KS+ + E Sbjct: 66 EEESDEGFQIPATITERYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGK--E 123 Query: 293 HQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSAT 472 H ++ EV I ++HPNI+ L T +YL++E G+L+ + ++ER ++ Sbjct: 124 HMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASG 183 Query: 473 YIASLARALIYLHGKHVIHRDIKPENLLV 559 + +LA A+ YLH +++HRDIKPENLLV Sbjct: 184 MLYNLASAIKYLHSLNIVHRDIKPENLLV 212
>KS6AB_XENLA (P10666) Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1)| (Ribosomal protein S6 kinase II beta) (S6KII-beta) (P90-RSK) Length = 629 Score = 89.7 bits (221), Expect = 5e-18 Identities = 52/146 (35%), Positives = 88/146 (60%), Gaps = 4/146 (2%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLARE---KRSSHIVALKVLFKSQLK-QSQVEHQLRREVEIQS 325 S F + K LG+G FG V+L R+ ++ + A+KVL K+ LK + +V ++ R++ Sbjct: 60 SHFVLLKVLGQGSFGKVFLVRKITPPDANQLYAMKVLKKATLKVRDRVRTKMERDILADV 119 Query: 326 HLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIY 505 H HP ++RL+ F + ++YLIL+ G+L+ L + F+E Y+A LA L + Sbjct: 120 H--HPFVVRLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 177 Query: 506 LHGKHVIHRDIKPENLLVGVQGELKI 583 LH +I+RD+KPEN+L+ +G +K+ Sbjct: 178 LHSLGIIYRDLKPENILLDEEGHIKL 203 Score = 71.2 bits (173), Expect = 2e-12 Identities = 46/147 (31%), Positives = 77/147 (52%), Gaps = 1/147 (0%) Frame = +2 Query: 119 PSQHSQEEKRWVLSD-FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEH 295 P HS K + +D + V + +G G + K ++ A+KV+ KS+ S+ Sbjct: 403 PKTHS---KNVLFTDVYTVRETIGVGSYSVCKRCVHKGTNMEYAVKVIDKSKRDPSEEIE 459 Query: 296 QLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATY 475 LRR + +HPNI+ L + + +YL+ E GEL + R K FSER + + Sbjct: 460 ILRR------YGQHPNIITLKDVYEECNSIYLVTELMRGGELLDRILRQKFFSEREACSV 513 Query: 476 IASLARALIYLHGKHVIHRDIKPENLL 556 + ++ + + YLH + V+HRD+KP N+L Sbjct: 514 LFTVCKTVEYLHSQGVVHRDLKPSNIL 540
>DCAK1_MOUSE (Q9JLM8) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 756 Score = 89.7 bits (221), Expect = 5e-18 Identities = 47/132 (35%), Positives = 78/132 (59%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 + VG+ +G G F V E+ ++ ALK++ KS+ + EH ++ EV I ++HPN Sbjct: 406 YKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGK--EHMIQNEVSILRRVKHPN 463 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I+ L T +YL++E G+L+ + ++ER ++ + +LA A+ YLH ++ Sbjct: 464 IVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNI 523 Query: 524 IHRDIKPENLLV 559 +HRDIKPENLLV Sbjct: 524 VHRDIKPENLLV 535
>RKIN1_SECCE (Q02723) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 502 Score = 89.7 bits (221), Expect = 5e-18 Identities = 46/147 (31%), Positives = 82/147 (55%), Gaps = 3/147 (2%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQS--- 325 L ++ +GK LG G F V +A K + H VA+KVL + Q++ ++E + +RE++I Sbjct: 11 LKNYYLGKILGVGTFAKVIIAEHKHTRHKVAIKVLNRRQMRAPEMEEKAKREIKILRLFI 70 Query: 326 HLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIY 505 L HP+I+R+Y +++++E+ G+L + + E + + A+ Y Sbjct: 71 DLIHPHIIRVYEVIVTPKDIFVVMEYCQNGDLLDYILEKRRLQEDEARRTFQQIISAVEY 130 Query: 506 LHGKHVIHRDIKPENLLVGVQGELKIA 586 H V+HRD+KPENLL+ + +K+A Sbjct: 131 CHRNKVVHRDLKPENLLLDSKYNVKLA 157
>ST38L_MOUSE (Q7TSE6) Serine/threonine-protein kinase 38-like (EC 2.7.11.1)| (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) Length = 464 Score = 89.7 bits (221), Expect = 5e-18 Identities = 49/171 (28%), Positives = 92/171 (53%), Gaps = 8/171 (4%) Frame = +2 Query: 98 DSRSEEKPSQHSQEEKRWV--------LSDFDVGKALGRGKFGHVYLAREKRSSHIVALK 253 D + + SQH+++E ++ L DF+ K + RG FG V L ++K + HI A+K Sbjct: 60 DEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIARGAFGEVRLVQKKDTGHIYAMK 119 Query: 254 VLFKSQLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKEL 433 +L K+ + + + +R E +I +++++ F D+ +YLI+E G++ L Sbjct: 120 ILRKADMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLL 179 Query: 434 QRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + +E + YI+ A+ +H IHRD+KP+NLL+ +G +K++ Sbjct: 180 MKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDVKPDNLLLDAKGHVKLS 230
>SNF1_SCHPO (O74536) SNF1-like protein kinase ssp2 (EC 2.7.11.1)| Length = 576 Score = 89.7 bits (221), Expect = 5e-18 Identities = 47/144 (32%), Positives = 79/144 (54%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + + + + LG G FG V LA ++ VALK + + LK+S + ++ RE+ LR Sbjct: 31 IGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLR 90 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HP+I++LY T + +++E+A GEL+ + K +E + + A+ Y H Sbjct: 91 HPHIIKLYDVITTPTDIVMVIEYAG-GELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHR 149 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 ++HRD+KPENLL+ +KIA Sbjct: 150 HKIVHRDLKPENLLLDDNLNVKIA 173
>STK36_MOUSE (Q69ZM6) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1268 Score = 89.7 bits (221), Expect = 5e-18 Identities = 49/143 (34%), Positives = 82/143 (57%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + + V + +G G FG VY R+K S+ +VALK + K + ++ + L+RE+EI L Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKELRN-LQREIEIMRGLW 59 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI+ + F V ++ ++A +GEL++ L+ E + A L AL YLH Sbjct: 60 HPNIVHMLDSFETDKEVVVVTDYA-EGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHS 118 Query: 515 KHVIHRDIKPENLLVGVQGELKI 583 ++HRD+KP+N+L+ G +K+ Sbjct: 119 HRILHRDMKPQNILLAKGGGIKL 141
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 89.7 bits (221), Expect = 5e-18 Identities = 43/155 (27%), Positives = 85/155 (54%) Frame = +2 Query: 122 SQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQL 301 ++ + + R + + +G LG G FG V + + + + H VA+K+L + +++ V ++ Sbjct: 4 AEKQKHDGRVRIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 63 Query: 302 RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIA 481 RRE++ RHP+I++LY + +++++E+ + GEL+ + + E+ S Sbjct: 64 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 123 Query: 482 SLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + + Y H V+HRD+KPEN+L+ KIA Sbjct: 124 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIA 158
>KBN8_YEAST (P38070) Probable serine/threonine-protein kinase YBR028C (EC| 2.7.11.1) Length = 525 Score = 89.7 bits (221), Expect = 5e-18 Identities = 53/167 (31%), Positives = 87/167 (52%), Gaps = 26/167 (15%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVE------ 316 L DF + LG+G +G V L ++ +S + A+K L K+++ SQ +RE E Sbjct: 125 LHDFKPVRVLGQGAYGKVLLVKDVNTSKLYAMKQLRKAEILISQTATDSKREDEDKNDGN 184 Query: 317 --------------------IQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQ 436 I S + HPNI++L+ F+D +++YL+L++ GEL+ L+ Sbjct: 185 NNDNDDGLSKRLERTFAERSILSEIEHPNIVKLFYSFHDNSKLYLLLQYIPGGELFYHLK 244 Query: 437 RCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGEL 577 E + Y A ++ AL +LH K V++RD+KPEN L+ +G L Sbjct: 245 EHGTLDETTVSFYAAEISCALRFLHTKGVVYRDLKPENCLLNQRGHL 291
>CBK1_DEBHA (Q6BLJ9) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 716 Score = 89.7 bits (221), Expect = 5e-18 Identities = 50/145 (34%), Positives = 86/145 (59%), Gaps = 1/145 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 L DF+ K +G+G FG V L +++ + I A+K L KS++ K+ Q+ H ++ E ++ + Sbjct: 312 LEDFNTVKVIGKGAFGEVRLVQKRDTGKIYAMKTLLKSEMYKKDQLAH-VKAERDVLAGS 370 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 P ++ LY F D +YLI+E G+L L R + F+E + Y+A A+ +H Sbjct: 371 DSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQIFTEDITRFYMAECVLAIEAIH 430 Query: 512 GKHVIHRDIKPENLLVGVQGELKIA 586 IHRDIKP+N+L+ ++G +K++ Sbjct: 431 KLGFIHRDIKPDNILIDIRGHIKLS 455
>CHK1_CHICK (Q8AYC9) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 89.4 bits (220), Expect = 7e-18 Identities = 44/144 (30%), Positives = 79/144 (54%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + D+D+ + LG G +G V LA +R+ VA+K++ + + +++E+ I L Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRRTEEAVAVKIV--DMKRAADCPENIKKEICINKMLN 63 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 H N+++ YG+ + YL LE+ + GEL+ ++ E + + L ++YLH Sbjct: 64 HENVVKFYGHRREGATQYLFLEYCSGGELFDRIEPDIGMPEPEAQRFFQQLIAGVVYLHS 123 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 + HRD+KPENLL+ + LKI+ Sbjct: 124 MGITHRDLKPENLLLDERDNLKIS 147
>CBK1_CANGA (Q6FP74) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 773 Score = 89.4 bits (220), Expect = 7e-18 Identities = 52/148 (35%), Positives = 86/148 (58%), Gaps = 1/148 (0%) Frame = +2 Query: 146 RWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQLRREVEIQ 322 R L DF + +G+G FG V L ++K + I A+K L KS++ K+ Q+ H ++ E ++ Sbjct: 364 RLSLEDFHTVQVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAH-VKAERDVL 422 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 + P I+ LY F D +YLI+E G+L L R + F+E + Y+A A+ Sbjct: 423 AGTDSPWIVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIE 482 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKIA 586 +H IHRDIKP+N+L+ ++G +K++ Sbjct: 483 TIHKLGFIHRDIKPDNILIDIRGHIKLS 510
>KPCL_RAT (Q64617) Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta)| (PKC-L) Length = 683 Score = 89.4 bits (220), Expect = 7e-18 Identities = 50/148 (33%), Positives = 83/148 (56%), Gaps = 1/148 (0%) Frame = +2 Query: 146 RWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQS 325 R+ + +F+ + LG+G FG V LAR K + + A+KVL K + Q E I S Sbjct: 349 RFGIDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILS 408 Query: 326 HLR-HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 R HP + +L+ F R++ ++E G+L +Q+ + F E R+ Y A + AL+ Sbjct: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 468 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKIA 586 +LH K +I+RD+K +N+L+ +G K+A Sbjct: 469 FLHEKGIIYRDLKLDNVLLDHEGHCKLA 496
>KPCL_MOUSE (P23298) Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta)| (PKC-L) Length = 683 Score = 89.4 bits (220), Expect = 7e-18 Identities = 50/148 (33%), Positives = 83/148 (56%), Gaps = 1/148 (0%) Frame = +2 Query: 146 RWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQS 325 R+ + +F+ + LG+G FG V LAR K + + A+KVL K + Q E I S Sbjct: 349 RFGIDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILS 408 Query: 326 HLR-HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 R HP + +L+ F R++ ++E G+L +Q+ + F E R+ Y A + AL+ Sbjct: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 468 Query: 503 YLHGKHVIHRDIKPENLLVGVQGELKIA 586 +LH K +I+RD+K +N+L+ +G K+A Sbjct: 469 FLHEKGIIYRDLKLDNVLLDHEGHCKLA 496
>CBK1_KLULA (P31034) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 718 Score = 89.4 bits (220), Expect = 7e-18 Identities = 49/147 (33%), Positives = 82/147 (55%) Frame = +2 Query: 146 RWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQS 325 R L DF+ K +G+G FG V L ++K + I A+K L KS++ ++ E ++ + Sbjct: 297 RLSLDDFNSVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYNKDQLAHVKAERDVLA 356 Query: 326 HLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIY 505 P ++ LY F D +YLI+E G+L L R + F+E + Y+A A+ Sbjct: 357 GSDSPWVVSLYYSFQDSQYLYLIMEFLPGGDLMTMLIRWQIFTEDVTRFYMAECILAIEV 416 Query: 506 LHGKHVIHRDIKPENLLVGVQGELKIA 586 +H IHRDIKP+N+L+ ++G +K++ Sbjct: 417 IHKLGFIHRDIKPDNILIDIRGHIKLS 443
>KGP1_DROME (Q03042) cGMP-dependent protein kinase, isozyme 1 (EC 2.7.11.12)| (CGK) Length = 768 Score = 89.4 bits (220), Expect = 7e-18 Identities = 58/170 (34%), Positives = 86/170 (50%), Gaps = 2/170 (1%) Frame = +2 Query: 80 AMAISTDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSH--IVALK 253 AM + +S +E Q QE L+D +V LG G FG V L + I ALK Sbjct: 429 AMKQAQESCRDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALK 488 Query: 254 VLFKSQLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKEL 433 L K + ++ E + E I R P I RLY F D+ VY++LE GE++ L Sbjct: 489 CLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTML 548 Query: 434 QRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 + F + + I + +A YLH + +I+RD+KPENL++ +G +KI Sbjct: 549 RDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKI 598
>STK38_MOUSE (Q91VJ4) Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1| protein kinase) (Nuclear Dbf2-related kinase 1) Length = 465 Score = 89.4 bits (220), Expect = 7e-18 Identities = 50/171 (29%), Positives = 91/171 (53%), Gaps = 8/171 (4%) Frame = +2 Query: 98 DSRSEEKPSQHSQEEKRWV--------LSDFDVGKALGRGKFGHVYLAREKRSSHIVALK 253 D + S H+++E ++ L DF+ K +GRG FG V L ++K + H+ A+K Sbjct: 59 DEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMK 118 Query: 254 VLFKSQLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKEL 433 +L K+ + + + +R E +I +++++ F D+ +YLI+E G++ L Sbjct: 119 ILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLL 178 Query: 434 QRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + +E + YIA A+ +H IHRDIKP+NLL+ +G +K++ Sbjct: 179 MKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLS 229
>STK38_HUMAN (Q15208) Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1| protein kinase) (Nuclear Dbf2-related kinase 1) Length = 465 Score = 89.4 bits (220), Expect = 7e-18 Identities = 50/171 (29%), Positives = 91/171 (53%), Gaps = 8/171 (4%) Frame = +2 Query: 98 DSRSEEKPSQHSQEEKRWV--------LSDFDVGKALGRGKFGHVYLAREKRSSHIVALK 253 D + S H+++E ++ L DF+ K +GRG FG V L ++K + H+ A+K Sbjct: 59 DEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMK 118 Query: 254 VLFKSQLKQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKEL 433 +L K+ + + + +R E +I +++++ F D+ +YLI+E G++ L Sbjct: 119 ILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLL 178 Query: 434 QRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + +E + YIA A+ +H IHRDIKP+NLL+ +G +K++ Sbjct: 179 MKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLS 229
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 89.4 bits (220), Expect = 7e-18 Identities = 47/157 (29%), Positives = 86/157 (54%), Gaps = 2/157 (1%) Frame = +2 Query: 122 SQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQL 301 ++ + + R + + +G LG G FG V + + + H VA+K+L + +++ V ++ Sbjct: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 Query: 302 RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH--FSERRSATY 475 +RE++ RHP+I++LY T ++++E+ + GEL+ + CKH E + Sbjct: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEVEARRL 119 Query: 476 IASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + A+ Y H V+HRD+KPEN+L+ Q KIA Sbjct: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIA 156
>NRC2_NEUCR (O42626) Serine/threonine-protein kinase nrc-2 (EC 2.7.11.1)| (Nonrepressible conidiation protein 2) Length = 623 Score = 89.4 bits (220), Expect = 7e-18 Identities = 53/144 (36%), Positives = 84/144 (58%), Gaps = 3/144 (2%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ-LKQSQVEHQLRREVEIQSHLRHP 340 FD K +G+G G VYL +EK+S + A+KVL K + +K+++++ L E EI + HP Sbjct: 242 FDKIKLIGKGDVGKVYLVKEKKSGRLYAMKVLSKKEMIKRNKIKRAL-AEQEILATSNHP 300 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQR--CKHFSERRSATYIASLARALIYLHG 514 I+ LY F + +YL +E+ + GE ++ LQ K E + Y A + AL YLH Sbjct: 301 FIVTLYHSFQSEDYLYLCMEYCSGGEFFRALQTRPGKCIPEDDARFYAAEVTAALEYLHL 360 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 I+RD+KPEN+L+ G + ++ Sbjct: 361 MGFIYRDLKPENILLHQSGHIMLS 384
>KPC1_YEAST (P24583) Protein kinase C-like 1 (EC 2.7.11.13) (PKC 1)| Length = 1151 Score = 89.0 bits (219), Expect = 9e-18 Identities = 52/167 (31%), Positives = 89/167 (53%), Gaps = 3/167 (1%) Frame = +2 Query: 95 TDSRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL 274 + + + K + + + ++ L +F + K LG+G FG V L++ K + + A+KVL K + Sbjct: 801 SQTSTSAKHKKRAAKRRKVSLDNFVLLKVLGKGNFGKVILSKSKNTDRLCAIKVLKKDNI 860 Query: 275 KQSQVEHQLRREVEI---QSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCK 445 Q+ R E ++ + +HP + LY F + R+Y +E G+L +Q + Sbjct: 861 IQNHDIESARAEKKVFLLATKTKHPFLTNLYCSFQTENRIYFAMEFIGGGDLMWHVQN-Q 919 Query: 446 HFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 S RR+ Y A + AL Y H VI+RD+K EN+L+ +G +KIA Sbjct: 920 RLSVRRAKFYAAEVLLALKYFHDNGVIYRDLKLENILLTPEGHIKIA 966
>KPCI_PONPY (Q5R4K9) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| Length = 587 Score = 89.0 bits (219), Expect = 9e-18 Identities = 49/169 (28%), Positives = 94/169 (55%), Gaps = 5/169 (2%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWV----LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVL 259 S D EEK + +++E + L DFD+ + +GRG + V L R K++ I A+KV+ Sbjct: 217 SLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVV 276 Query: 260 FKSQLKQSQVEHQLRREVEI-QSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQ 436 K + + ++ E + + HP ++ L+ F ++R++ ++E+ G+L +Q Sbjct: 277 KKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQ 336 Query: 437 RCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 R + E + Y A ++ AL YLH + +I+RD+K +N+L+ +G +K+ Sbjct: 337 RQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKL 385
>KPCI_HUMAN (P41743) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota) Length = 587 Score = 89.0 bits (219), Expect = 9e-18 Identities = 49/169 (28%), Positives = 94/169 (55%), Gaps = 5/169 (2%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWV----LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVL 259 S D EEK + +++E + L DFD+ + +GRG + V L R K++ I A+KV+ Sbjct: 217 SLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVV 276 Query: 260 FKSQLKQSQVEHQLRREVEI-QSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQ 436 K + + ++ E + + HP ++ L+ F ++R++ ++E+ G+L +Q Sbjct: 277 KKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQ 336 Query: 437 RCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 R + E + Y A ++ AL YLH + +I+RD+K +N+L+ +G +K+ Sbjct: 337 RQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKL 385
>CDPK1_ORYSA (P53682) Calcium-dependent protein kinase, isoform 1 (EC 2.7.11.1)| (CDPK 1) Length = 534 Score = 89.0 bits (219), Expect = 9e-18 Identities = 46/133 (34%), Positives = 77/133 (57%), Gaps = 1/133 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR-HP 340 + +G+ LG+G+FG YL E + A K + KS L+ +RRE++I HL Sbjct: 73 YTLGRELGQGQFGKTYLCTEISTGCQYACKTILKSNLRCVSDIEDVRREIQIMHHLSGQK 132 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKH 520 NI+ + + D+ V++++E A GEL+ ++Q+ H+SER++A I + + H Sbjct: 133 NIVTIKDTYEDEQAVHIVMELCAGGELFSKIQKRGHYSERKAAELIKIIVGIIETCHSHG 192 Query: 521 VIHRDIKPENLLV 559 V+HRD+KPEN L+ Sbjct: 193 VMHRDLKPENFLL 205
>KPCI_MOUSE (Q62074) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) Length = 586 Score = 89.0 bits (219), Expect = 9e-18 Identities = 49/169 (28%), Positives = 94/169 (55%), Gaps = 5/169 (2%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWV----LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVL 259 S D EEK + +++E + L DFD+ + +GRG + V L R K++ I A+KV+ Sbjct: 216 SLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVV 275 Query: 260 FKSQLKQSQVEHQLRREVEI-QSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQ 436 K + + ++ E + + HP ++ L+ F ++R++ ++E+ G+L +Q Sbjct: 276 KKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQ 335 Query: 437 RCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 R + E + Y A ++ AL YLH + +I+RD+K +N+L+ +G +K+ Sbjct: 336 RQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKL 384
>KPC1B_CAEEL (P34885) Protein kinase C-like 1B (EC 2.7.11.13) (PKC1B)| Length = 707 Score = 89.0 bits (219), Expect = 9e-18 Identities = 47/145 (32%), Positives = 80/145 (55%), Gaps = 1/145 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQ-VEHQLRREVEIQSHL 331 + DF K LG+G FG V LA K + + A+K+L K + Q VE + + + Sbjct: 375 IHDFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAA 434 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 +HP + L+ F R++ ++E+ G+L ++QR + F E R+ Y A + AL +LH Sbjct: 435 KHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLH 494 Query: 512 GKHVIHRDIKPENLLVGVQGELKIA 586 VI+RD+K +N+L+ +G ++A Sbjct: 495 RNDVIYRDLKLDNILLDAEGHCRLA 519
>SCK1_SCHPO (P50530) Serine/threonine-protein kinase sck1 (EC 2.7.11.1)| Length = 696 Score = 89.0 bits (219), Expect = 9e-18 Identities = 53/152 (34%), Positives = 87/152 (57%), Gaps = 3/152 (1%) Frame = +2 Query: 137 EEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVEHQL-RRE 310 E R+ DF + +G+G FG VYL R+ ++ I A+K + K + ++ +V H L R Sbjct: 293 EHVRYGPEDFTALRLIGKGTFGQVYLVRKNDTNRIYAMKKISKKLIVRKKEVTHTLGERN 352 Query: 311 VEIQSHL-RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASL 487 + +++ L P I+ L F + +YLI ++ + GEL+ LQ F E+R+ YIA L Sbjct: 353 ILVRTSLDESPFIVGLKFSFQTASDLYLITDYMSGGELFWHLQHEGRFPEQRAKFYIAEL 412 Query: 488 ARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 AL +LH +I+RD+KPEN+L+ G + + Sbjct: 413 VLALEHLHKHDIIYRDLKPENILLDADGHIAL 444
>ST32A_MOUSE (Q8BGW6) Serine/threonine-protein kinase 32A (EC 2.7.11.1)| Length = 398 Score = 89.0 bits (219), Expect = 9e-18 Identities = 43/140 (30%), Positives = 80/140 (57%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 F++ +A+G+G FG V + R+ + + A+K + K + + + +E++I L HP Sbjct: 23 FEILRAIGKGSFGKVCIVRKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPF 82 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 ++ L+ F D+ ++++++ G+L LQ+ HF E +I LA AL YL + + Sbjct: 83 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFQEDTVKLFICELAMALDYLQSQRI 142 Query: 524 IHRDIKPENLLVGVQGELKI 583 IHRD+KP+N+L+ G + I Sbjct: 143 IHRDMKPDNILLDEHGHVHI 162
>PKN2_HUMAN (Q16513) Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein| kinase C-like 2) (Protein-kinase C-related kinase 2) Length = 984 Score = 88.6 bits (218), Expect = 1e-17 Identities = 54/162 (33%), Positives = 90/162 (55%), Gaps = 3/162 (1%) Frame = +2 Query: 110 EEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQ 286 +E + SQ+ ++ L DF LGRG FG V LA K ++ + A+K L K + + + Sbjct: 639 QELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDE 698 Query: 287 VEHQL--RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSER 460 V+ + +R E + +RHP ++ L+ F + V ++E+AA G+L + FSE Sbjct: 699 VDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEP 757 Query: 461 RSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 R+ Y A + L YLH +++RD+K +NLL+ +G +KIA Sbjct: 758 RAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIA 799
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 88.6 bits (218), Expect = 1e-17 Identities = 47/134 (35%), Positives = 78/134 (58%), Gaps = 1/134 (0%) Frame = +2 Query: 158 SDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQ-LRREVEIQSHLR 334 +++ G+ LG G FG V AR+ ++ VA+K+L K L+ + V+ Q L E+ I L Sbjct: 45 TNYIFGRTLGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLS 104 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 HPNI+ +F + + Y++ + A GEL+ + F+E + I + A+ Y+H Sbjct: 105 HPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHS 164 Query: 515 KHVIHRDIKPENLL 556 K+V+HRD+KPEN+L Sbjct: 165 KNVVHRDLKPENVL 178
>STK33_HUMAN (Q9BYT3) Serine/threonine-protein kinase 33 (EC 2.7.11.1)| Length = 514 Score = 88.2 bits (217), Expect = 2e-17 Identities = 50/132 (37%), Positives = 75/132 (56%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 + G+ LG+G FG V A +K + A+K + K + S V+ L REV I ++H + Sbjct: 116 YTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVK-LLEREVNILKSVKHEH 174 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I+ L F ++YL++E GEL + L R HFSE + I SLA A+ YLH + Sbjct: 175 IIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDI 234 Query: 524 IHRDIKPENLLV 559 +HRD+K EN++V Sbjct: 235 VHRDLKLENIMV 246
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 88.2 bits (217), Expect = 2e-17 Identities = 46/157 (29%), Positives = 85/157 (54%), Gaps = 2/157 (1%) Frame = +2 Query: 122 SQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQL 301 ++ + + R + + +G LG G FG V + + + H VA+K+L + +++ V ++ Sbjct: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 Query: 302 RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH--FSERRSATY 475 +RE++ RHP+I++LY T ++++E+ + GEL+ + CKH E + Sbjct: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRL 119 Query: 476 IASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + A+ Y H V+HRD+KPEN+L+ KIA Sbjct: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIA 156
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 88.2 bits (217), Expect = 2e-17 Identities = 46/157 (29%), Positives = 85/157 (54%), Gaps = 2/157 (1%) Frame = +2 Query: 122 SQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQL 301 ++ + + R + + +G LG G FG V + + + H VA+K+L + +++ V ++ Sbjct: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 Query: 302 RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH--FSERRSATY 475 +RE++ RHP+I++LY T ++++E+ + GEL+ + CKH E + Sbjct: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRL 119 Query: 476 IASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + A+ Y H V+HRD+KPEN+L+ KIA Sbjct: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIA 156
>YPK2_YEAST (P18961) Serine/threonine-protein kinase YPK2/YKR2 (EC 2.7.11.1)| Length = 677 Score = 88.2 bits (217), Expect = 2e-17 Identities = 60/157 (38%), Positives = 86/157 (54%), Gaps = 1/157 (0%) Frame = +2 Query: 116 KPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQVE 292 KPS++ K + DFD+ K +G+G FG V R+K + I ALK L K+ + + +V Sbjct: 332 KPSKN----KPLSIDDFDLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVT 387 Query: 293 HQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSAT 472 H L E + + + P I+ L F ++YL+L GEL+ LQ FS RS Sbjct: 388 HTLA-ERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRF 446 Query: 473 YIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 YIA L AL LH VI+RD+KPEN+L+ QG + + Sbjct: 447 YIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIAL 483
>KCC4_HUMAN (Q16566) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 473 Score = 88.2 bits (217), Expect = 2e-17 Identities = 57/151 (37%), Positives = 81/151 (53%), Gaps = 4/151 (2%) Frame = +2 Query: 146 RWVLSDF-DVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQ 322 R LSDF +V LGRG VY ++K + ALKVL K+ K+ +R E+ + Sbjct: 39 RDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI-----VRTEIGVL 93 Query: 323 SHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALI 502 L HPNI++L F T + L+LE GEL+ + ++SER +A + + A+ Sbjct: 94 LRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVA 153 Query: 503 YLHGKHVIHRDIKPENLLVGV---QGELKIA 586 YLH ++HRD+KPENLL LKIA Sbjct: 154 YLHENGIVHRDLKPENLLYATPAPDAPLKIA 184
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 88.2 bits (217), Expect = 2e-17 Identities = 51/158 (32%), Positives = 78/158 (49%), Gaps = 14/158 (8%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVE-------------- 292 + + +G+ LG G G V LAR + A+KV+ K+ V Sbjct: 16 IGPWKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALP 75 Query: 293 HQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSAT 472 + + RE+ I L HPN+LRLY + T +YL+LE+A KGEL+ L E + Sbjct: 76 YGIEREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIR 135 Query: 473 YIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + + + Y H ++HRD+KPENLL+ + +KIA Sbjct: 136 FFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIA 173
>PLK2_CAEEL (Q9N2L7) Serine/threonine-protein kinase plk-2 (EC 2.7.11.21)| (Polo-like kinase 2) Length = 632 Score = 87.8 bits (216), Expect = 2e-17 Identities = 44/140 (31%), Positives = 81/140 (57%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 ++ GK LG+G F H Y R K + + A KV+ K+ L + ++ +EV+I +L+H N Sbjct: 36 YEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRN 95 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 +++LY +F D++ VY+ LE + L + +R K +E + + + ++YLH + Sbjct: 96 VVKLYHFFEDKSNVYITLELCPRRSLMELHKRRKAVTEPEARYFTYQIVEGVLYLHNLKI 155 Query: 524 IHRDIKPENLLVGVQGELKI 583 +HRD+K NL + + ++KI Sbjct: 156 VHRDLKLGNLFLNDELQVKI 175
>KPC3_DROME (P13678) Protein kinase C (EC 2.7.11.13) (PKC) (dPKC98F)| Length = 634 Score = 87.8 bits (216), Expect = 2e-17 Identities = 49/145 (33%), Positives = 81/145 (55%), Gaps = 1/145 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQ-VEHQLRREVEIQSHL 331 L DF+ K LG+G FG V LA +K + I A+KVL K + Q V+ + + + Sbjct: 300 LLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAA 359 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 HP + L+ F R++ ++E+ G+L ++Q+ + F R+A Y A + AL +LH Sbjct: 360 NHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLH 419 Query: 512 GKHVIHRDIKPENLLVGVQGELKIA 586 VI+RD+K +N+L+ +G K+A Sbjct: 420 THGVIYRDLKLDNILLDQEGHCKLA 444
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 87.4 bits (215), Expect = 3e-17 Identities = 46/141 (32%), Positives = 79/141 (56%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 + + K LG G FG V LA+ + VALK++ + L +S ++ ++ RE+ LRHP+ Sbjct: 53 YQILKTLGEGSFGKVKLAQHLGTGQKVALKIINRKTLAKSDMQGRVEREISYLRLLRHPH 112 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I++LY + + +++E A K EL+ + + E + + + A+ Y H + Sbjct: 113 IIKLYDVIKSKDEIIMVIEFAGK-ELFDYIVQRGKMPEDEARRFFQQIIAAVEYCHRHKI 171 Query: 524 IHRDIKPENLLVGVQGELKIA 586 +HRD+KPENLL+ Q +KIA Sbjct: 172 VHRDLKPENLLLDDQLNVKIA 192
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 87.4 bits (215), Expect = 3e-17 Identities = 46/141 (32%), Positives = 79/141 (56%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 + + K LG G FG V LA+ + VALK++ + L +S ++ ++ RE+ LRHP+ Sbjct: 52 YQIIKTLGEGSFGKVKLAQHVGTGQKVALKIINRKTLAKSDMQGRVEREISYLRLLRHPH 111 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 I++LY + + +++E A K EL+ + + E + + + A+ Y H + Sbjct: 112 IIKLYDVIKSKDEIIMVIEFAGK-ELFDYIVQRGKMPEDEARRFFQQIIAAVEYCHRHKI 170 Query: 524 IHRDIKPENLLVGVQGELKIA 586 +HRD+KPENLL+ Q +KIA Sbjct: 171 VHRDLKPENLLLDDQLNVKIA 191
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 87.4 bits (215), Expect = 3e-17 Identities = 44/129 (34%), Positives = 77/129 (59%) Frame = +2 Query: 170 VGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPNIL 349 + + LG+G +G VY +K ++ + A+K K +LK ++ +E+EI L HPNI+ Sbjct: 73 IDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNI---NRFFQEIEIMKKLDHPNIV 129 Query: 350 RLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVIH 529 +LY + + +YLI+E + EL+ + F+E+ +AT + + A+ YLH +++H Sbjct: 130 KLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVH 189 Query: 530 RDIKPENLL 556 RD+KPEN L Sbjct: 190 RDLKPENFL 198
>KOK0_YEAST (Q12236) Probable serine/threonine-protein kinase YOL100W (EC| 2.7.11.1) Length = 1081 Score = 87.4 bits (215), Expect = 3e-17 Identities = 53/170 (31%), Positives = 91/170 (53%), Gaps = 5/170 (2%) Frame = +2 Query: 89 ISTDSRSEEKPSQHSQEEKRWVLS----DFDVGKALGRGKFGHVYLAREKRSSHIVALKV 256 I DS S++ ++ S + ++ ++ DF G +G G + V LA + A KV Sbjct: 150 IEHDSSSQKPIAKESSKAQKNIIKKGIKDFKFGSVIGDGAYSTVMLATSIDTKKRYAAKV 209 Query: 257 LFKSQL-KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKEL 433 L K L +Q +V++ + +Q P+++RL+ F D++ +Y +LE+A G+ + Sbjct: 210 LNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLM 269 Query: 434 QRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 ++ E + Y A + A+ YLH +IHRDIKPEN+L + GE+KI Sbjct: 270 KKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENIL--LDGEMKI 317
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 87.4 bits (215), Expect = 3e-17 Identities = 44/129 (34%), Positives = 77/129 (59%) Frame = +2 Query: 170 VGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPNIL 349 + + LG+G +G VY +K ++ + A+K K +LK ++ +E+EI L HPNI+ Sbjct: 73 IDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNI---NRFFQEIEIMKKLDHPNIV 129 Query: 350 RLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVIH 529 +LY + + +YLI+E + EL+ + F+E+ +AT + + A+ YLH +++H Sbjct: 130 KLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVH 189 Query: 530 RDIKPENLL 556 RD+KPEN L Sbjct: 190 RDLKPENFL 198
>CDPK3_ORYSA (P53684) Calcium-dependent protein kinase, isoform 11 (EC 2.7.11.1)| (CDPK 11) Length = 542 Score = 87.4 bits (215), Expect = 3e-17 Identities = 45/131 (34%), Positives = 74/131 (56%), Gaps = 1/131 (0%) Frame = +2 Query: 170 VGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR-HPNI 346 +G+ LG+G+FG YL E + A K + K +L + +RRE++I HL H N+ Sbjct: 81 IGRKLGQGQFGTTYLCTEINTGCEYACKTIPKRKLITKEDVEDVRREIQIMHHLSGHKNV 140 Query: 347 LRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVI 526 + + + D V++++E A GEL+ +Q H+SER++A I + + H V+ Sbjct: 141 VAIKDVYEDGQAVHIVMELCAGGELFDRIQEKGHYSERKAAELIRIIVSIVAMCHSLGVM 200 Query: 527 HRDIKPENLLV 559 HRD+KPEN L+ Sbjct: 201 HRDLKPENFLL 211
>CHK1_XENLA (Q6DE87) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (xChk1| protein) Length = 474 Score = 87.0 bits (214), Expect = 4e-17 Identities = 46/144 (31%), Positives = 79/144 (54%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + D+D+ + LG G +G V LA +++ VA+K++ + + +++E+ I L Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRKTEEAVAVKIV--DMTRAADCPENIKKEICINRMLS 63 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 H NI+R YG+ + YL LE+ GEL+ ++ E+ + + L + YLH Sbjct: 64 HTNIVRFYGHRREGNIQYLFLEYCRGGELFDRIEPDVGMPEQDAQKFFQQLIAGVEYLHS 123 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 + HRDIKPENLL+ + +LKI+ Sbjct: 124 IGITHRDIKPENLLLDERDQLKIS 147
>PKN2_MOUSE (Q8BWW9) Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein| kinase C-like 2) (Protein-kinase C-related kinase 2) Length = 983 Score = 87.0 bits (214), Expect = 4e-17 Identities = 53/161 (32%), Positives = 89/161 (55%), Gaps = 3/161 (1%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQV 289 E + +Q+ ++ L DF LGRG FG V LA K ++ + A+K L K + + +V Sbjct: 639 ELDDKRAQQRFQFSLQDFRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEV 698 Query: 290 EHQL--RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERR 463 + + +R E + +RHP ++ L+ F + V ++E+AA G+L + FSE R Sbjct: 699 DSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPR 757 Query: 464 SATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + Y A + L YLH +++RD+K +NLL+ +G +KIA Sbjct: 758 AVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIA 798
>CDPK_SOYBN (P28583) Calcium-dependent protein kinase SK5 (EC 2.7.11.1) (CDPK)| Length = 508 Score = 87.0 bits (214), Expect = 4e-17 Identities = 45/132 (34%), Positives = 76/132 (57%), Gaps = 1/132 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL-RHP 340 ++VG+ LG+G+FG + + S A K + K +L + + RE++I HL H Sbjct: 34 YEVGRKLGQGQFGTTFECTRRASGGKFACKSIPKRKLLCKEDYEDVWREIQIMHHLSEHA 93 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKH 520 N++R+ G + D T V+L++E GEL+ + + H+SER++A I ++ + H Sbjct: 94 NVVRIEGTYEDSTAVHLVMELCEGGELFDRIVQKGHYSERQAARLIKTIVEVVEACHSLG 153 Query: 521 VIHRDIKPENLL 556 V+HRD+KPEN L Sbjct: 154 VMHRDLKPENFL 165
>KS6B1_RAT (P67999) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (p70-S6K) Length = 525 Score = 87.0 bits (214), Expect = 4e-17 Identities = 49/144 (34%), Positives = 88/144 (61%), Gaps = 4/144 (2%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSH---IVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 F++ + LG+G +G V+ R+ ++ I A+KVL K+ + + ++ + E I + Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 +HP I+ L F ++YLILE+ + GEL+ +L+R F E + Y+A ++ AL +LH Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 210 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 K +I+RD+KPEN+++ QG +K+ Sbjct: 211 QKGIIYRDLKPENIMLNHQGHVKL 234
>KS6B1_RABIT (P67998) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (p70-S6K) Length = 525 Score = 87.0 bits (214), Expect = 4e-17 Identities = 49/144 (34%), Positives = 88/144 (61%), Gaps = 4/144 (2%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSH---IVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 F++ + LG+G +G V+ R+ ++ I A+KVL K+ + + ++ + E I + Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 +HP I+ L F ++YLILE+ + GEL+ +L+R F E + Y+A ++ AL +LH Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 210 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 K +I+RD+KPEN+++ QG +K+ Sbjct: 211 QKGIIYRDLKPENIMLNHQGHVKL 234
>KS6B1_MOUSE (Q8BSK8) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (p70-S6K) Length = 525 Score = 87.0 bits (214), Expect = 4e-17 Identities = 49/144 (34%), Positives = 88/144 (61%), Gaps = 4/144 (2%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSH---IVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 F++ + LG+G +G V+ R+ ++ I A+KVL K+ + + ++ + E I + Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 +HP I+ L F ++YLILE+ + GEL+ +L+R F E + Y+A ++ AL +LH Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 210 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 K +I+RD+KPEN+++ QG +K+ Sbjct: 211 QKGIIYRDLKPENIMLNHQGHVKL 234
>KS6B1_HUMAN (P23443) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (p70-alpha) Length = 525 Score = 87.0 bits (214), Expect = 4e-17 Identities = 49/144 (34%), Positives = 88/144 (61%), Gaps = 4/144 (2%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSH---IVALKVLFKSQL-KQSQVEHQLRREVEIQSHL 331 F++ + LG+G +G V+ R+ ++ I A+KVL K+ + + ++ + E I + Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 +HP I+ L F ++YLILE+ + GEL+ +L+R F E + Y+A ++ AL +LH Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 210 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 K +I+RD+KPEN+++ QG +K+ Sbjct: 211 QKGIIYRDLKPENIMLNHQGHVKL 234
>KGP1A_RABIT (O77676) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 87.0 bits (214), Expect = 4e-17 Identities = 50/144 (34%), Positives = 78/144 (54%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREK-RSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 LSDF++ LG G FG V L + K S A+K+L K + ++ + +R E +I Sbjct: 356 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 415 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 I+RLY F D +Y+++E GEL+ L+ F + + Y A + A YLH Sbjct: 416 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 475 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 K +I+RD+KPENL++ +G K+ Sbjct: 476 SKGIIYRDLKPENLILDHRGYAKL 499
>KGP1A_HUMAN (Q13976) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 87.0 bits (214), Expect = 4e-17 Identities = 50/144 (34%), Positives = 78/144 (54%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREK-RSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 LSDF++ LG G FG V L + K S A+K+L K + ++ + +R E +I Sbjct: 356 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 415 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 I+RLY F D +Y+++E GEL+ L+ F + + Y A + A YLH Sbjct: 416 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 475 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 K +I+RD+KPENL++ +G K+ Sbjct: 476 SKGIIYRDLKPENLILDHRGYAKL 499
>KGP1A_BOVIN (P00516) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 87.0 bits (214), Expect = 4e-17 Identities = 50/144 (34%), Positives = 78/144 (54%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREK-RSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 LSDF++ LG G FG V L + K S A+K+L K + ++ + +R E +I Sbjct: 356 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 415 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 I+RLY F D +Y+++E GEL+ L+ F + + Y A + A YLH Sbjct: 416 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 475 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 K +I+RD+KPENL++ +G K+ Sbjct: 476 SKGIIYRDLKPENLILDHRGYAKL 499
>KGP1B_MOUSE (Q9Z0Z0) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 87.0 bits (214), Expect = 4e-17 Identities = 50/144 (34%), Positives = 78/144 (54%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREK-RSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 LSDF++ LG G FG V L + K S A+K+L K + ++ + +R E +I Sbjct: 372 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 431 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 I+RLY F D +Y+++E GEL+ L+ F + + Y A + A YLH Sbjct: 432 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 491 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 K +I+RD+KPENL++ +G K+ Sbjct: 492 SKGIIYRDLKPENLILDHRGYAKL 515
>KGP1B_HUMAN (P14619) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 87.0 bits (214), Expect = 4e-17 Identities = 50/144 (34%), Positives = 78/144 (54%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREK-RSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 LSDF++ LG G FG V L + K S A+K+L K + ++ + +R E +I Sbjct: 372 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 431 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 I+RLY F D +Y+++E GEL+ L+ F + + Y A + A YLH Sbjct: 432 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 491 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 K +I+RD+KPENL++ +G K+ Sbjct: 492 SKGIIYRDLKPENLILDHRGYAKL 515
>KGP1B_BOVIN (P21136) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 87.0 bits (214), Expect = 4e-17 Identities = 50/144 (34%), Positives = 78/144 (54%), Gaps = 1/144 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREK-RSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 LSDF++ LG G FG V L + K S A+K+L K + ++ + +R E +I Sbjct: 372 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 431 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 I+RLY F D +Y+++E GEL+ L+ F + + Y A + A YLH Sbjct: 432 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 491 Query: 512 GKHVIHRDIKPENLLVGVQGELKI 583 K +I+RD+KPENL++ +G K+ Sbjct: 492 SKGIIYRDLKPENLILDHRGYAKL 515
>CHK1_RAT (Q91ZN7) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 86.7 bits (213), Expect = 5e-17 Identities = 45/144 (31%), Positives = 79/144 (54%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLR 334 + D+D+ + LG G +G V LA + + VA+K++ + +++E+ I L Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRITEEAVAVKIV--DMKRAIDCPENIKKEICINKMLN 63 Query: 335 HPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHG 514 H N+++ YG+ + YL LE+ + GEL+ ++ E+ + + L ++YLHG Sbjct: 64 HENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHG 123 Query: 515 KHVIHRDIKPENLLVGVQGELKIA 586 + HRDIKPENLL+ + LKI+ Sbjct: 124 IGITHRDIKPENLLLDERDNLKIS 147
>KPCL_HUMAN (P24723) Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta)| (PKC-L) Length = 682 Score = 86.7 bits (213), Expect = 5e-17 Identities = 47/145 (32%), Positives = 81/145 (55%), Gaps = 1/145 (0%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQ-LKQSQVEHQLRREVEIQSHL 331 + +F+ + LG+G FG V LAR K + + A+KVL K L VE + + + Sbjct: 351 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILLDDDVECTMTEKRILSLAR 410 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 HP + +L+ F R++ ++E G+L +Q+ + F E R+ Y A + AL++LH Sbjct: 411 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLH 470 Query: 512 GKHVIHRDIKPENLLVGVQGELKIA 586 K +I+RD+K +N+L+ +G K+A Sbjct: 471 DKGIIYRDLKLDNVLLDHEGHCKLA 495
>PKN2_RAT (O08874) Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein| kinase C-like 2) (Protein-kinase C-related kinase 2) (Protease-activated kinase 2) (PAK-2) (Fragment) Length = 842 Score = 86.7 bits (213), Expect = 5e-17 Identities = 53/161 (32%), Positives = 88/161 (54%), Gaps = 3/161 (1%) Frame = +2 Query: 113 EKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQL-KQSQV 289 E + SQ+ ++ L DF LGRG FG V LA K ++ + A+K L K + + +V Sbjct: 504 ELEDKRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEV 563 Query: 290 EHQL--RREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERR 463 + + +R E + +RHP ++ L+ F + V ++E+AA G+L + FSE R Sbjct: 564 DSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPR 622 Query: 464 SATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 + Y A + L YLH +++RD+K +NLL+ + +KIA Sbjct: 623 AVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEASVKIA 663
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 86.7 bits (213), Expect = 5e-17 Identities = 45/140 (32%), Positives = 74/140 (52%), Gaps = 12/140 (8%) Frame = +2 Query: 176 KALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQ------------SQVEHQLRREVEI 319 + LG G +G V L REK A+KV+ KSQ + ++ ++ E+ + Sbjct: 59 RKLGSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITNKIECDDKIHEEIYNEISL 118 Query: 320 QSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARAL 499 L HPNI++L+ F D+ YL+ E GEL++++ F E +A + + + Sbjct: 119 LKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGI 178 Query: 500 IYLHGKHVIHRDIKPENLLV 559 YLH +++HRDIKPEN+L+ Sbjct: 179 CYLHKHNIVHRDIKPENILL 198
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 86.7 bits (213), Expect = 5e-17 Identities = 45/140 (32%), Positives = 74/140 (52%), Gaps = 12/140 (8%) Frame = +2 Query: 176 KALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQ------------SQVEHQLRREVEI 319 + LG G +G V L REK A+KV+ KSQ + ++ ++ E+ + Sbjct: 59 RKLGSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITNKIECDDKIHEEIYNEISL 118 Query: 320 QSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARAL 499 L HPNI++L+ F D+ YL+ E GEL++++ F E +A + + + Sbjct: 119 LKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGI 178 Query: 500 IYLHGKHVIHRDIKPENLLV 559 YLH +++HRDIKPEN+L+ Sbjct: 179 CYLHKHNIVHRDIKPENILL 198
>KN8R_YEAST (P53739) Probable serine/threonine-protein kinase YNR047W (EC| 2.7.11.1) Length = 893 Score = 86.7 bits (213), Expect = 5e-17 Identities = 49/143 (34%), Positives = 81/143 (56%), Gaps = 2/143 (1%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 F+ + LG+G G V+L REK+++ + ALKVL K ++ + ++ E EI + HP Sbjct: 496 FEKIRLLGQGDVGKVFLVREKKTNRVYALKVLSKDEMIKRNKIKRVLTEQEILATSNHPF 555 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQ--RCKHFSERRSATYIASLARALIYLHGK 517 I+ LY F + +YL +E+ GE ++ LQ + K E + Y + + AL YLH Sbjct: 556 IVTLYHSFQSEDYLYLCMEYCMGGEFFRALQTRKTKCICEDDARFYASEVTAALEYLHLL 615 Query: 518 HVIHRDIKPENLLVGVQGELKIA 586 I+RD+KPEN+L+ G + ++ Sbjct: 616 GFIYRDLKPENILLHQSGHIMLS 638
>KIN4_YEAST (Q01919) Serine/threonine-protein kinase KIN4 (EC 2.7.11.1)| Length = 800 Score = 86.7 bits (213), Expect = 5e-17 Identities = 51/158 (32%), Positives = 80/158 (50%), Gaps = 6/158 (3%) Frame = +2 Query: 128 HSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHI-----VALKVLFKSQLKQ-SQV 289 H + K + +G LG G+FG V L K SS VA+K++ + +K+ + Sbjct: 34 HKNQRKHATFGPYIIGSTLGEGEFGKVKLGWTKASSSNEVPKQVAIKLIRRDTIKKDADK 93 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 E ++ RE+ HL HPNI+ L + + ++LE + GE YK +QR + E + Sbjct: 94 EIKIYREINALKHLTHPNIIYLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSAC 153 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 A L + Y+H K ++HRD+K ENLL+ L I Sbjct: 154 RLFAQLISGVNYMHYKGLVHRDLKLENLLLDKHENLVI 191
>KDC1_DROME (P16911) Protein kinase DC1 (EC 2.7.11.1)| Length = 376 Score = 86.7 bits (213), Expect = 5e-17 Identities = 53/165 (32%), Positives = 85/165 (51%), Gaps = 4/165 (2%) Frame = +2 Query: 101 SRSEEKPSQHSQEEKRWVLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQ 280 SR E+ H + L ++ LG G FG V L REK + A K++ K L + Sbjct: 24 SREFEERWNHQTQSPYTNLENYITRAVLGNGSFGTVMLVREKSGKNYYAAKMMSKEDLVR 83 Query: 281 SQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTR----VYLILEHAAKGELYKELQRCKH 448 + + E + + R P ++ Y D T+ +YLIL GEL+ +R + Sbjct: 84 LKQVAHVHNEKHVLNAARFPFLI----YLVDSTKCFDYLYLILPLVNGGELFSYHRRVRK 139 Query: 449 FSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 F+E+ + Y A +A AL Y+H H+++RD+KPEN+L+ +G +KI Sbjct: 140 FNEKHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQRGYIKI 184
>DAPK2_MOUSE (Q8VDF3) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 86.7 bits (213), Expect = 5e-17 Identities = 51/150 (34%), Positives = 84/150 (56%), Gaps = 4/150 (2%) Frame = +2 Query: 122 SQHSQEEKRWVLSDF-DVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQ---V 289 S + + K+ + DF D+G+ LG G+F V REK + A K + K Q + S+ Sbjct: 8 SPNMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVC 67 Query: 290 EHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSA 469 ++ REV I + HPNI+ L+ + ++T V LILE + GEL+ L + + SE + Sbjct: 68 REEIEREVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEAT 127 Query: 470 TYIASLARALIYLHGKHVIHRDIKPENLLV 559 ++I + + YLH K + H D+KPEN+++ Sbjct: 128 SFIKQILDGVNYLHTKKIAHFDLKPENIML 157
>ST32A_HUMAN (Q8WU08) Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1)| Length = 396 Score = 86.7 bits (213), Expect = 5e-17 Identities = 41/140 (29%), Positives = 79/140 (56%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 F++ +A+G+G FG V + ++ + + A+K + K + + + +E++I L HP Sbjct: 23 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPF 82 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKHV 523 ++ L+ F D+ ++++++ G+L LQ+ HF E +I L AL YL + + Sbjct: 83 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRI 142 Query: 524 IHRDIKPENLLVGVQGELKI 583 IHRD+KP+N+L+ G + I Sbjct: 143 IHRDMKPDNILLDEHGHVHI 162
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 86.3 bits (212), Expect = 6e-17 Identities = 45/142 (31%), Positives = 77/142 (54%), Gaps = 1/142 (0%) Frame = +2 Query: 164 FDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHPN 343 + + + +GRG +G VY A K + +VA+K + + + + + E+ + +L H N Sbjct: 25 YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVV---YENDEELNDIMAEISLLKNLNHNN 81 Query: 344 ILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKH-FSERRSATYIASLARALIYLHGKH 520 I++ +G+ +Y++LE+ A G L + + R SE S TY+ L YLHG+ Sbjct: 82 IVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEG 141 Query: 521 VIHRDIKPENLLVGVQGELKIA 586 VIHRDIK N+L+ +K+A Sbjct: 142 VIHRDIKAANILLSADNTVKLA 163
>KCC1B_RAT (O70150) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 86.3 bits (212), Expect = 6e-17 Identities = 44/135 (32%), Positives = 76/135 (56%) Frame = +2 Query: 152 VLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 + S +++ + LG G F V LA+E+ S+H+VALK + K L+ E + E+ + + Sbjct: 11 ISSVYEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKALRGK--EALVENEIAVLRRI 68 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 HPNI+ L + +YL +E GEL+ + ++E+ ++ + + A+ YLH Sbjct: 69 SHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLH 128 Query: 512 GKHVIHRDIKPENLL 556 ++HRD+KPENLL Sbjct: 129 SLGIVHRDLKPENLL 143
>KCC1B_MOUSE (Q9QYK9) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog) Length = 343 Score = 86.3 bits (212), Expect = 6e-17 Identities = 44/135 (32%), Positives = 76/135 (56%) Frame = +2 Query: 152 VLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 + S +++ + LG G F V LA+E+ S+H+VALK + K L+ E + E+ + + Sbjct: 11 ISSVYEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKALRGK--EALVENEIAVLRRI 68 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 HPNI+ L + +YL +E GEL+ + ++E+ ++ + + A+ YLH Sbjct: 69 SHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLH 128 Query: 512 GKHVIHRDIKPENLL 556 ++HRD+KPENLL Sbjct: 129 SLGIVHRDLKPENLL 143
>KCC1B_HUMAN (Q6P2M8) Calcium/calmodulin-dependent protein kinase type 1B (EC| 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase) Length = 343 Score = 86.3 bits (212), Expect = 6e-17 Identities = 44/135 (32%), Positives = 76/135 (56%) Frame = +2 Query: 152 VLSDFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHL 331 + S +++ + LG G F V LA+E+ S+H+VALK + K L+ E + E+ + + Sbjct: 11 ISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGK--EALVENEIAVLRRI 68 Query: 332 RHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLH 511 HPNI+ L + +YL +E GEL+ + ++E+ ++ + + A+ YLH Sbjct: 69 SHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLH 128 Query: 512 GKHVIHRDIKPENLL 556 ++HRD+KPENLL Sbjct: 129 SLGIVHRDLKPENLL 143
>JIL1_DROME (Q9V3I5) Chromosomal serine/threonine-protein kinase JIL-1 (EC| 2.7.11.1) Length = 1207 Score = 86.3 bits (212), Expect = 6e-17 Identities = 50/149 (33%), Positives = 85/149 (57%), Gaps = 5/149 (3%) Frame = +2 Query: 155 LSDFDVGKALGRGKFGHVYLAREKR---SSHIVALKVLFKSQL--KQSQVEHQLRREVEI 319 L+DF + + LG G +G V+L R+ + + A+KVL K + K+ EH V + Sbjct: 258 LNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVL 317 Query: 320 QSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARAL 499 ++ R+P ++ L+ F +++YL+L+ A GEL+ L ++F E R YIA + AL Sbjct: 318 EAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLAL 377 Query: 500 IYLHGKHVIHRDIKPENLLVGVQGELKIA 586 LH +I+RDIK EN+L+ +G + ++ Sbjct: 378 EQLHQLGIIYRDIKLENILLDGEGHIVLS 406 Score = 54.3 bits (129), Expect = 3e-07 Identities = 29/132 (21%), Positives = 64/132 (48%) Frame = +2 Query: 161 DFDVGKALGRGKFGHVYLAREKRSSHIVALKVLFKSQLKQSQVEHQLRREVEIQSHLRHP 340 D ++G G +G + + + + K++ S+ + S+V+ + ++ +H Sbjct: 622 DLELGTRTSNGAYGTCHFVVDSSTDLVFLAKIIPLSKFRPSEVDALISCALDTTNH---K 678 Query: 341 NILRLYGYFYDQTRVYLILEHAAKGELYKELQRCKHFSERRSATYIASLARALIYLHGKH 520 NI+ +G F ++ ++++E+ + EL ++ E L A+ ++H KH Sbjct: 679 NIVSYHGTFREKCETWIVMEYLSGPELTASIR----MDEDSCREIFLQLVMAVRHIHSKH 734 Query: 521 VIHRDIKPENLL 556 IH D+KPEN++ Sbjct: 735 FIHGDLKPENIM 746
>KPCI_BRARE (Q90XF2) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (Heart and soul protein) Length = 588 Score = 86.3 bits (212), Expect = 6e-17 Identities = 49/169 (28%), Positives = 93/169 (55%), Gaps = 5/169 (2%) Frame = +2 Query: 92 STDSRSEEKPSQHSQEEKRWVLS----DFDVGKALGRGKFGHVYLAREKRSSHIVALKVL 259 S + EE + S+E + V S DFD+ + +GRG + V L R K++ I A+KV+ Sbjct: 218 SINHEGEEHEAVGSRESGKAVSSLGLIDFDLLRVIGRGSYAKVLLVRLKKTERIYAMKVV 277 Query: 260 FKSQLKQSQVEHQLRREVEI-QSHLRHPNILRLYGYFYDQTRVYLILEHAAKGELYKELQ 436 K + + ++ E + + HP ++ L+ F ++R++ ++E+ G+L +Q Sbjct: 278 KKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQ 337 Query: 437 RCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKI 583 R + E + Y A ++ AL YLH + +I+RD+K +N+L+ +G +K+ Sbjct: 338 RQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKL 386
>CBK1_PNECA (Q6TGC6) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 507 Score = 86.3 bits (212), Expect = 6e-17 Identities = 57/179 (31%), Positives = 96/179 (53%), Gaps = 13/179 (7%) Frame = +2 Query: 89 ISTDSRSEEKPSQH----SQEEKRWV--------LSDFDVGKALGRGKFGHVYLAREKRS 232 ++ D SEE+ + Q+E +++ L+DF K +G+G FG V L ++ + Sbjct: 89 LAQDRGSEERKKRQLNSLGQKESQFLRLRRTKLSLNDFHTVKVIGKGAFGEVRLVQKIDT 148 Query: 233 SHIVALKVLFKSQL-KQSQVEHQLRREVEIQSHLRHPNILRLYGYFYDQTRVYLILEHAA 409 I A+K L KS++ K+ Q+ H ++ E ++ + P ++ LY F D +YLI+E Sbjct: 149 GKIYAMKTLLKSEMFKKDQLAH-VKAERDVLAESDSPWVVSLYYSFQDSQYLYLIMEFLP 207 Query: 410 KGELYKELQRCKHFSERRSATYIASLARALIYLHGKHVIHRDIKPENLLVGVQGELKIA 586 G+L L + FSE + YIA A+ +H IHRDIKP+N+L+ G +K++ Sbjct: 208 GGDLMTMLIKYDTFSEDVTRFYIAECILAIEAVHKLGFIHRDIKPDNILIDKTGHIKLS 266 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 73,840,059 Number of Sequences: 219361 Number of extensions: 1425144 Number of successful extensions: 7589 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5940 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6232 length of database: 80,573,946 effective HSP length: 106 effective length of database: 57,321,680 effective search space used: 5044307840 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
