ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bart13d08 |
|---|---|
| Clone Library Name | barley_pub |
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 88.6 bits (218), Expect = 1e-17 Identities = 46/129 (35%), Positives = 76/129 (58%), Gaps = 3/129 (2%) Frame = +3 Query: 174 KVGGARQLSWAQVEAMTAGFTS-AVVGEGSFSTVYLARLAGSSQLAAVKVHRSSE--RLR 344 K+ A++ S+ ++E T GF+ + VG+GSFS V+ L + +A + ++S+ + Sbjct: 486 KIRRAQEFSYEELEQATGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKRAIKASDVKKSS 545 Query: 345 RAFRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPW 524 + F ELD L R+ H H++ LL +C+ E +LV EF +GSL+ HLH ++ L W Sbjct: 546 KEFHNELDLLSRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLHGKDPNLKKRLNW 605 Query: 525 ARRAAVALQ 551 ARR +A+Q Sbjct: 606 ARRVTIAVQ 614
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 72.8 bits (177), Expect = 6e-13 Identities = 39/113 (34%), Positives = 63/113 (55%) Frame = +3 Query: 210 VEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRH 389 VEA ++G+G F TVY A L G +A K+ + + R F E++ L +V+H Sbjct: 911 VEATDHFSKKNIIGDGGFGTVYKACLPGEKTVAVKKLSEAKTQGNREFMAEMETLGKVKH 970 Query: 390 PHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVAL 548 P++V LL +C +E +LV E+ NGSL DH ++ + L W++R +A+ Sbjct: 971 PNLVSLLGYCSFSEEKLLVYEYMVNGSL-DHWLRNQTGMLEVLDWSKRLKIAV 1022
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 68.9 bits (167), Expect = 9e-12 Identities = 37/119 (31%), Positives = 65/119 (54%), Gaps = 1/119 (0%) Frame = +3 Query: 192 QLSWAQVEAMTAGFTSA-VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELD 368 +LS + T+ F A ++G G F VY A L +++A ++ + ++ R F+ E++ Sbjct: 730 ELSLDDILKSTSSFNQANIIGCGGFGLVYKATLPDGTKVAIKRLSGDTGQMDREFQAEVE 789 Query: 369 ALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVA 545 L R +HP++V LL +C+ +++ +L+ + NGSL LH K P L W R +A Sbjct: 790 TLSRAQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLH-EKVDGPPSLDWKTRLRIA 847
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 68.2 bits (165), Expect = 2e-11 Identities = 43/122 (35%), Positives = 62/122 (50%), Gaps = 2/122 (1%) Frame = +3 Query: 186 ARQLSWAQVEAMTAGF-TSAVVGEGSFSTVYLARLAGSSQLAAVK-VHRSSERLRRAFRQ 359 A ++ ++ A T F +GEG F VY RL + Q+ AVK + R+ + R F Sbjct: 71 AHTFAFRELAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGNREFLV 130 Query: 360 ELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAA 539 E+ L + HP++V L+ +C D+ +LV EF P GSL DHLH L W R Sbjct: 131 EVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPPD-KEALDWNMRMK 189 Query: 540 VA 545 +A Sbjct: 190 IA 191
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/121 (34%), Positives = 65/121 (53%), Gaps = 1/121 (0%) Frame = +3 Query: 189 RQLSWAQVEAMTAGF-TSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQEL 365 R+L++A + T GF +++G G F VY A L S +A K+ S + R F E+ Sbjct: 869 RKLTFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEM 928 Query: 366 DALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVA 545 + + +++H ++V LL +C DE +LV EF GSL D LH K L W+ R +A Sbjct: 929 ETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPK-KAGVKLNWSTRRKIA 987 Query: 546 L 548 + Sbjct: 988 I 988
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 67.4 bits (163), Expect = 3e-11 Identities = 41/122 (33%), Positives = 64/122 (52%), Gaps = 2/122 (1%) Frame = +3 Query: 186 ARQLSWAQVEAMTAGFTS-AVVGEGSFSTVYLARLAGSSQLAAVK-VHRSSERLRRAFRQ 359 A+ ++ ++ T F S +GEG F V+ + Q+ A+K + R+ + R F Sbjct: 88 AQTFTFQELAEATGNFRSDCFLGEGGFGKVFKGTIEKLDQVVAIKQLDRNGVQGIREFVV 147 Query: 360 ELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAA 539 E+ L HP++V+L+ FC + D+ +LV E+ P GSL DHLH S PL W R Sbjct: 148 EVLTLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHV-LPSGKKPLDWNTRMK 206 Query: 540 VA 545 +A Sbjct: 207 IA 208
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 67.0 bits (162), Expect = 3e-11 Identities = 41/121 (33%), Positives = 66/121 (54%), Gaps = 1/121 (0%) Frame = +3 Query: 189 RQLSWAQVEAMTAGF-TSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQEL 365 R+L++A + T GF ++VG G F VY A+L S +A K+ S + R F E+ Sbjct: 874 RKLTFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEM 933 Query: 366 DALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVA 545 + + +++H ++V LL +C +E +LV E+ GSL D LH K + L W R +A Sbjct: 934 ETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRK-KIGIKLNWPARRKIA 992 Query: 546 L 548 + Sbjct: 993 I 993
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 66.2 bits (160), Expect = 6e-11 Identities = 38/121 (31%), Positives = 68/121 (56%), Gaps = 1/121 (0%) Frame = +3 Query: 189 RQLSWAQVEAMTAGFTS-AVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQEL 365 R+L++A + T GF++ +++G G F VY A+LA S +A K+ + + + R F E+ Sbjct: 844 RKLTFAHLLEATNGFSADSMIGSGGFGDVYKAKLADGSVVAIKKLIQVTGQGDREFMAEM 903 Query: 366 DALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVA 545 + + +++H ++V LL +C +E +LV E+ GSL LH L W+ R +A Sbjct: 904 ETIGKIKHRNLVPLLGYCKIGEERLLVYEYMKYGSLETVLHEKTKKGGIFLDWSARKKIA 963 Query: 546 L 548 + Sbjct: 964 I 964
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 65.9 bits (159), Expect = 8e-11 Identities = 41/121 (33%), Positives = 65/121 (53%), Gaps = 1/121 (0%) Frame = +3 Query: 189 RQLSWAQVEAMTAGF-TSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQEL 365 R+L++A + T GF ++VG G F VY A+L S +A K+ S + R F E+ Sbjct: 874 RKLTFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEM 933 Query: 366 DALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVA 545 + + +++H ++V LL +C +E +LV E+ GSL D LH K L W R +A Sbjct: 934 ETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRK-KTGIKLNWPARRKIA 992 Query: 546 L 548 + Sbjct: 993 I 993
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 65.9 bits (159), Expect = 8e-11 Identities = 41/121 (33%), Positives = 66/121 (54%), Gaps = 2/121 (1%) Frame = +3 Query: 189 RQLSWAQVEAMTAGFTSA-VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQEL 365 R+L ++Q+ T GF++A ++G G F V+ A L S +A K+ R S + R F E+ Sbjct: 824 RKLKFSQLIEATNGFSAASMIGHGGFGEVFKATLKDGSSVAIKKLIRLSCQGDREFMAEM 883 Query: 366 DALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPP-LPWARRAAV 542 + L +++H ++V LL +C +E +LV EF GSL + LH + L W R + Sbjct: 884 ETLGKIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKI 943 Query: 543 A 545 A Sbjct: 944 A 944
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does| not make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 65.1 bits (157), Expect = 1e-10 Identities = 41/103 (39%), Positives = 59/103 (57%), Gaps = 1/103 (0%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRS-SERLRRAFRQELDALLRVRHPHIVRLLAFC 419 ++GEG F +VY L Q AVKV S S + R F EL+ L ++H ++V LL +C Sbjct: 601 LIGEGGFGSVYRGTL-DDGQEVAVKVRSSTSTQGTREFDNELNLLSAIQHENLVPLLGYC 659 Query: 420 DQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVAL 548 ++ D+ +LV F NGSL D L+ +AS L W R ++AL Sbjct: 660 NEYDQQILVYPFMSNGSLLDRLY-GEASKRKILDWPTRLSIAL 701
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 64.3 bits (155), Expect = 2e-10 Identities = 37/104 (35%), Positives = 55/104 (52%), Gaps = 1/104 (0%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVK-VHRSSERLRRAFRQELDALLRVRHPHIVRLLAFC 419 ++G+G VY + + +A + V R + R F E+ L R+RH HIVRLL + Sbjct: 697 IIGKGGAGIVYRGSMPNNVDVAIKRLVGRGTGRSDHGFTAEIQTLGRIRHRHIVRLLGYV 756 Query: 420 DQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQ 551 +D +L+ E+ PNGSL + LH SK L W R VA++ Sbjct: 757 ANKDTNLLLYEYMPNGSLGELLHGSKGG---HLQWETRHRVAVE 797
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 63.9 bits (154), Expect = 3e-10 Identities = 39/127 (30%), Positives = 64/127 (50%), Gaps = 3/127 (2%) Frame = +3 Query: 183 GARQLSWAQVEAMTAGFTSA-VVGEGSFSTVYLARLAGSSQLAAVKVHRS--SERLRRAF 353 G +S + ++T F+S ++G G F VY L +++A ++ + + F Sbjct: 572 GNMLISIQVLRSVTNNFSSDNILGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKGFAEF 631 Query: 354 RQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARR 533 + E+ L +VRH H+V LL +C +E +LV E+ P G+L HL PL W +R Sbjct: 632 KSEIAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLLWKQR 691 Query: 534 AAVALQV 554 +AL V Sbjct: 692 LTLALDV 698
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 63.5 bits (153), Expect = 4e-10 Identities = 41/122 (33%), Positives = 67/122 (54%), Gaps = 2/122 (1%) Frame = +3 Query: 189 RQLSWAQVEAMTAGFTS-AVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQEL 365 R+L++A + T GF++ +VG G F VY A+L S +A K+ R + + R F E+ Sbjct: 845 RKLTFAHLLEATNGFSAETMVGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGDREFMAEM 904 Query: 366 DALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLH-ASKASVSPPLPWARRAAV 542 + + +++H ++V LL +C +E +LV E+ GSL LH S L WA R + Sbjct: 905 ETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKI 964 Query: 543 AL 548 A+ Sbjct: 965 AI 966
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 63.2 bits (152), Expect = 5e-10 Identities = 35/102 (34%), Positives = 55/102 (53%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCD 422 ++GEG F +VY L ++A +S + R F EL+ L ++H ++V LL +C+ Sbjct: 600 LIGEGGFGSVYRGTLDDGQEVAVKVRSATSTQGTREFDNELNLLSAIQHENLVPLLGYCN 659 Query: 423 QRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVAL 548 + D+ +LV F NGSL D L+ A L W R ++AL Sbjct: 660 EYDQQILVYPFMSNGSLLDRLYGEPAK-RKILDWPTRLSIAL 700
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 62.4 bits (150), Expect = 8e-10 Identities = 39/106 (36%), Positives = 55/106 (51%), Gaps = 5/106 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERL-----RRAFRQELDALLRVRHPHIVRLL 410 +GEG F VY A + + + AVK + + L +++F E++ L R RHP+IV Sbjct: 218 IGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFA 275 Query: 411 AFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVAL 548 +C Q LV F PNGSL D LH + PPL W +R + L Sbjct: 276 GYCAQNGFYCLVYGFLPNGSLEDRLHC-QTQACPPLSWPQRLDILL 320
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 61.6 bits (148), Expect = 1e-09 Identities = 39/108 (36%), Positives = 60/108 (55%), Gaps = 1/108 (0%) Frame = +3 Query: 234 TSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLA 413 T V+ + S+ TVY A+L+ +A + + + R + + L R+RH ++V L A Sbjct: 375 TGQVMEKTSYGTVYKAKLSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRA 434 Query: 414 FCD-QRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQV 554 F +R E +L+ ++ PN SLHD LH SK P L WARR +AL + Sbjct: 435 FYQGKRGEKLLIYDYLPNISLHDLLHESKPR-KPALNWARRHKIALGI 481
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 60.5 bits (145), Expect = 3e-09 Identities = 40/131 (30%), Positives = 71/131 (54%), Gaps = 11/131 (8%) Frame = +3 Query: 189 RQLSWAQVEAMTAGFT-SAVVGEGSFSTVY---------LARLAGSSQLAAVK-VHRSSE 335 + ++A+++A T F +V+GEG F +V+ A G+ + AVK +++ Sbjct: 55 KSFTFAELKAATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPGTGVVIAVKKLNQDGW 114 Query: 336 RLRRAFRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPP 515 + + + E++ L + HP++V+L+ +C + + +LV EF P GSL +HL + S P Sbjct: 115 QGHQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHLF-RRGSYFQP 173 Query: 516 LPWARRAAVAL 548 L W R VAL Sbjct: 174 LSWTLRLKVAL 184
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 59.7 bits (143), Expect = 5e-09 Identities = 39/138 (28%), Positives = 70/138 (50%), Gaps = 8/138 (5%) Frame = +3 Query: 159 QQQPGKVG--------GARQLSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAV 314 +QQ G +G R +++V +T F V+G+G F VY + G Q+A Sbjct: 544 KQQRGTLGERNGPLKTAKRYFKYSEVVNITNNF-ERVIGKGGFGKVYHGVINGE-QVAVK 601 Query: 315 KVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHAS 494 + S + + FR E+D L+RV H ++ L+ +C++ + VL+ E+ N +L D+L Sbjct: 602 VLSEESAQGYKEFRAEVDLLMRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYLAGK 661 Query: 495 KASVSPPLPWARRAAVAL 548 ++ + L W R ++L Sbjct: 662 RSFI---LSWEERLKISL 676
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 59.7 bits (143), Expect = 5e-09 Identities = 36/120 (30%), Positives = 60/120 (50%), Gaps = 1/120 (0%) Frame = +3 Query: 189 RQLSWAQVEAMTAGFTSA-VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQEL 365 ++LS+ + T F A ++G G F VY A L ++A K+ ++ R F E+ Sbjct: 720 KELSYDDLLDSTNSFDQANIIGCGGFGMVYKATLPDGKKVAIKKLSGDCGQIEREFEAEV 779 Query: 366 DALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVA 545 + L R +HP++V L FC +++ +L+ + NGSL LH + L W R +A Sbjct: 780 ETLSRAQHPNLVLLRGFCFYKNDRLLIYSYMENGSLDYWLH-ERNDGPALLKWKTRLRIA 838
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 59.3 bits (142), Expect = 7e-09 Identities = 41/112 (36%), Positives = 54/112 (48%), Gaps = 10/112 (8%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRS---------SERLRR-AFRQELDALLRVRHP 392 V+G GS VY L G +A K+++S S+ L R F E++ L +RH Sbjct: 688 VIGFGSSGKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAEVETLGTIRHK 747 Query: 393 HIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVAL 548 IVRL C D +LV E+ PNGSL D LH + L W R +AL Sbjct: 748 SIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKG-GVVLGWPERLRIAL 798
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 59.3 bits (142), Expect = 7e-09 Identities = 40/122 (32%), Positives = 61/122 (50%), Gaps = 6/122 (4%) Frame = +3 Query: 201 WAQVEAMTAGFTSAV-VGEGSFSTVYLARLAGSSQLAAVKVHRSSERL-----RRAFRQE 362 + ++ T F+ + +GEG F VY A + ++ AVK + L +++F E Sbjct: 202 FCEISQGTCNFSEELRIGEGGFGCVYRAVMRNTTY--AVKRLKEEADLEWTMVKQSFLTE 259 Query: 363 LDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAV 542 ++ L R RHP+IV +C + LV F PNGSL D LH + S PL W +R + Sbjct: 260 VEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACS-PLSWPQRLDI 318 Query: 543 AL 548 L Sbjct: 319 LL 320
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 58.9 bits (141), Expect = 9e-09 Identities = 39/105 (37%), Positives = 54/105 (51%), Gaps = 5/105 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVK-----VHRSSERLRRAFRQELDALLRVRHPHIVRLL 410 +GEG F VY + ++ + AVK V S+E L++ F QE+ + +H ++V LL Sbjct: 192 MGEGGFGVVYKGCV--NNTIVAVKKLGAMVEISTEELKQQFDQEIKVMATCQHENLVELL 249 Query: 411 AFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVA 545 F D LV + PNGSL D L S +PPL W R VA Sbjct: 250 GFSSDSDNLCLVYAYMPNGSLLDRL--SCLDGTPPLSWHTRCKVA 292
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 58.5 bits (140), Expect = 1e-08 Identities = 37/104 (35%), Positives = 57/104 (54%), Gaps = 4/104 (3%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSS----QLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLA 413 +GEG F VY + ++ +LAA+ V ++E L++ F QE+ + + +H ++V LL Sbjct: 192 MGEGGFGVVYKGYVNNTTVAVKKLAAM-VDITTEELKQQFDQEIKVMAKCQHENLVELLG 250 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVA 545 F D+ LV + PNGSL D L S +PPL W R +A Sbjct: 251 FSSDGDDLCLVYVYMPNGSLLDRL--SCLDGTPPLSWHMRCKIA 292
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 56.2 bits (134), Expect = 6e-08 Identities = 39/131 (29%), Positives = 68/131 (51%), Gaps = 11/131 (8%) Frame = +3 Query: 189 RQLSWAQVEAMTAGFT-SAVVGEGSFSTVY---------LARLAGSSQLAAVK-VHRSSE 335 + S+A++++ T F +V+GEG F V+ A G+ + AVK +++ Sbjct: 54 KSFSFAELKSATRNFRPDSVLGEGGFGCVFKGWIDEKSLTASRPGTGLVIAVKKLNQDGW 113 Query: 336 RLRRAFRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPP 515 + + + E++ L + H H+V+L+ +C + + +LV EF P GSL +HL + P Sbjct: 114 QGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENHLF-RRGLYFQP 172 Query: 516 LPWARRAAVAL 548 L W R VAL Sbjct: 173 LSWKLRLKVAL 183
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 55.8 bits (133), Expect = 8e-08 Identities = 36/131 (27%), Positives = 68/131 (51%), Gaps = 11/131 (8%) Frame = +3 Query: 189 RQLSWAQVEAMTAGFT-SAVVGEGSFSTVYLARLAGSSQ----------LAAVKVHRSSE 335 + S +++++ T F +VVGEG F V+ + SS +A ++++ Sbjct: 54 KNFSLSELKSATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRLNQEGF 113 Query: 336 RLRRAFRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPP 515 + R + E++ L ++ HP++V+L+ +C + + +LV EF GSL +HL + + P Sbjct: 114 QGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLF-RRGTFYQP 172 Query: 516 LPWARRAAVAL 548 L W R +AL Sbjct: 173 LSWNTRVRMAL 183
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 55.5 bits (132), Expect = 1e-07 Identities = 32/88 (36%), Positives = 48/88 (54%), Gaps = 4/88 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS----ERLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G F VYLARL S + A+KV S E L R+E++ ++HP+I+RL Sbjct: 49 LGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYN 108 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHLHASK 497 + L+LE+AP G L+ L S+ Sbjct: 109 YFHDARRVYLILEYAPRGELYKELQKSE 136
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 55.5 bits (132), Expect = 1e-07 Identities = 34/109 (31%), Positives = 58/109 (53%), Gaps = 5/109 (4%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLR-----RAFRQELDALLRVRHPHIVRL 407 ++GEG VY R+ +Q AVK+ + ++++ + F EL+ LL RHPHI+ L Sbjct: 183 LIGEGEIFEVY--RVDIRNQAYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILEL 240 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQV 554 A+ + ++ LV + NG+L D L + + PL W R +V + + Sbjct: 241 AAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTT--PLSWHVRISVLIGI 287
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 53.1 bits (126), Expect = 5e-07 Identities = 34/126 (26%), Positives = 63/126 (50%), Gaps = 2/126 (1%) Frame = +3 Query: 177 VGGARQLSWAQVEAMTAGFTSA-VVGEGSFSTVYLARLAGSSQLAAVKVHRS-SERLRRA 350 +G ++ S +++ + F++ ++G G F VY RLA + +A ++ ++ Sbjct: 271 LGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQ 330 Query: 351 FRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWAR 530 F+ E++ + H +++RL FC E +LV + NGS+ L S PPL W + Sbjct: 331 FQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPES-QPPLDWPK 389 Query: 531 RAAVAL 548 R +AL Sbjct: 390 RQRIAL 395
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 53.1 bits (126), Expect = 5e-07 Identities = 38/103 (36%), Positives = 49/103 (47%), Gaps = 5/103 (4%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRA-----FRQELDALLRVRHPHIVRL 407 ++G G F VY A G Q AVK R A R+E +RHP+I+ L Sbjct: 129 LIGAGGFGQVYRATWQG--QEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIEL 186 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRA 536 C Q+ LVLEFA G+L+ L A+ A+ P P RRA Sbjct: 187 RGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRA 229
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 53.1 bits (126), Expect = 5e-07 Identities = 35/96 (36%), Positives = 54/96 (56%), Gaps = 5/96 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLA--GSSQLAAVKVHR--SSERLRRAFRQELDALLRV-RHPHIVRL 407 V+GEG+F V AR+ G AA+K + +S+ R F EL+ L ++ HP+I+ L Sbjct: 827 VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINL 886 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPP 515 L C+ R L +E+AP+G+L D L S+ + P Sbjct: 887 LGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDP 922
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 53.1 bits (126), Expect = 5e-07 Identities = 35/96 (36%), Positives = 54/96 (56%), Gaps = 5/96 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLA--GSSQLAAVKVHR--SSERLRRAFRQELDALLRV-RHPHIVRL 407 V+GEG+F V AR+ G AA+K + +S+ R F EL+ L ++ HP+I+ L Sbjct: 829 VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINL 888 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPP 515 L C+ R L +E+AP+G+L D L S+ + P Sbjct: 889 LGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDP 924
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 53.1 bits (126), Expect = 5e-07 Identities = 35/96 (36%), Positives = 54/96 (56%), Gaps = 5/96 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLA--GSSQLAAVKVHR--SSERLRRAFRQELDALLRV-RHPHIVRL 407 V+GEG+F V AR+ G AA+K + +S+ R F EL+ L ++ HP+I+ L Sbjct: 830 VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINL 889 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPP 515 L C+ R L +E+AP+G+L D L S+ + P Sbjct: 890 LGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDP 925
>TIE2_BRARE (O73791) Tyrosine-protein kinase receptor Tie-2 precursor (EC| 2.7.10.1) Length = 1116 Score = 52.8 bits (125), Expect = 7e-07 Identities = 43/124 (34%), Positives = 61/124 (49%), Gaps = 6/124 (4%) Frame = +3 Query: 195 LSWAQVEAMTAGFTSAVVGEGSFSTVYLARLA--GSSQLAAVKVHR--SSERLRRAFRQE 362 L W+ ++ V+GEG+F V AR+ G AAVK + +S+ R F E Sbjct: 811 LQWSDIQFQD------VLGEGNFGQVLKARIRKDGLRMDAAVKRMKDYASQDDHRDFAGE 864 Query: 363 LDALLRVR-HPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKA-SVSPPLPWARRA 536 L+ L R+ H +I+ LL C+ R L +EFAP+G+L D L S+ P A R Sbjct: 865 LEVLCRLGPHKNIIHLLGACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPAFAIAHRT 924 Query: 537 AVAL 548 A L Sbjct: 925 ASTL 928
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 52.8 bits (125), Expect = 7e-07 Identities = 30/103 (29%), Positives = 58/103 (56%), Gaps = 1/103 (0%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVK-VHRSSERLRRAFRQELDALLRVRHPHIVRLLAFC 419 V+G+G+ T+Y A L+ A K V + + +E++ + +VRH ++++L F Sbjct: 821 VIGKGAHGTIYKATLSPDKVYAVKKLVFTGIKNGSVSMVREIETIGKVRHRNLIKLEEFW 880 Query: 420 DQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVAL 548 +++ G+++ + NGSLHD LH + + PL W+ R +A+ Sbjct: 881 LRKEYGLILYTYMENGSLHDILH--ETNPPKPLDWSTRHNIAV 921
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 52.4 bits (124), Expect = 9e-07 Identities = 34/104 (32%), Positives = 53/104 (50%), Gaps = 3/104 (2%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 VG GS+ V + +L AVK +S ++ +E+ L RV+HP+I+ L Sbjct: 25 VGHGSYGVV--CKAVWRDKLVAVKEFFASAE-QKDIEKEVKQLSRVKHPNIIALHGISSY 81 Query: 426 RDEGVLVLEFAPNGSLHDHLHAS---KASVSPPLPWARRAAVAL 548 + L++EFA GSLH+ LH S++ + WAR+ A L Sbjct: 82 QQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGL 125
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 52.0 bits (123), Expect = 1e-06 Identities = 39/121 (32%), Positives = 63/121 (52%) Frame = +3 Query: 162 QQPGKVGGARQLSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERL 341 + P +V ++ + ++E VVG G+F V A+ + +A ++ SER Sbjct: 20 EAPSQVLNFEEIDYKEIEV------EEVVGRGAFGVVCKAKWR-AKDVAIKQIESESER- 71 Query: 342 RRAFRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLP 521 +AF EL L RV HP+IV+L C + LV+E+A GSL++ LH ++ PLP Sbjct: 72 -KAFIVELRQLSRVNHPNIVKLYGAC--LNPVCLVMEYAEGGSLYNVLHGAE-----PLP 123 Query: 522 W 524 + Sbjct: 124 Y 124
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 52.0 bits (123), Expect = 1e-06 Identities = 29/88 (32%), Positives = 47/88 (53%), Gaps = 7/88 (7%) Frame = +3 Query: 243 VVGEGSFSTVYL---ARLAGSSQLAAVKVH----RSSERLRRAFRQELDALLRVRHPHIV 401 V+GEG+F V+L A L ++ A V V S+ L+R F +E + L + H +IV Sbjct: 509 VIGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGSCSDSLKRDFEREAEMLATIEHANIV 568 Query: 402 RLLAFCDQRDEGVLVLEFAPNGSLHDHL 485 C + D+ +++ EF NG L+ +L Sbjct: 569 TFYGVCTESDQWMMIFEFMENGDLNKYL 596
>AURKB_HUMAN (Q96GD4) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1) (Aurora-B) Length = 344 Score = 52.0 bits (123), Expect = 1e-06 Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 4/87 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS----ERLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G F VYLAR S + A+KV S E + R+E++ + HP+I+RL Sbjct: 83 LGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYN 142 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHLHAS 494 + R L+LE+AP G L+ L S Sbjct: 143 YFYDRRRIYLILEYAPRGELYKELQKS 169
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 52.0 bits (123), Expect = 1e-06 Identities = 39/121 (32%), Positives = 63/121 (52%) Frame = +3 Query: 162 QQPGKVGGARQLSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERL 341 + P +V ++ + ++E VVG G+F V A+ + +A ++ SER Sbjct: 20 EAPSQVLNFEEIDYKEIEV------EEVVGRGAFGVVCKAKWR-AKDVAIKQIESESER- 71 Query: 342 RRAFRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLP 521 +AF EL L RV HP+IV+L C + LV+E+A GSL++ LH ++ PLP Sbjct: 72 -KAFIVELRQLSRVNHPNIVKLYGAC--LNPVCLVMEYAEGGSLYNVLHGAE-----PLP 123 Query: 522 W 524 + Sbjct: 124 Y 124
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 52.0 bits (123), Expect = 1e-06 Identities = 33/96 (34%), Positives = 53/96 (55%), Gaps = 5/96 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLA--GSSQLAAVKVHR--SSERLRRAFRQELDALLRV-RHPHIVRL 407 ++GEG+F V A + G AA+K+ + +SE R F EL+ L ++ HP+I+ L Sbjct: 840 LIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINL 899 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPP 515 L C+ R + +E+AP G+L D L S+ + P Sbjct: 900 LGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDP 935
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 52.0 bits (123), Expect = 1e-06 Identities = 33/96 (34%), Positives = 53/96 (55%), Gaps = 5/96 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLA--GSSQLAAVKVHR--SSERLRRAFRQELDALLRV-RHPHIVRL 407 ++GEG+F V A + G AA+K+ + +SE R F EL+ L ++ HP+I+ L Sbjct: 842 LIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINL 901 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPP 515 L C+ R + +E+AP G+L D L S+ + P Sbjct: 902 LGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDP 937
>PTK7_CHICK (Q91048) Tyrosine-protein kinase-like 7 precursor (Kinase-like| protein) Length = 1051 Score = 51.6 bits (122), Expect = 1e-06 Identities = 36/117 (30%), Positives = 58/117 (49%), Gaps = 10/117 (8%) Frame = +3 Query: 234 TSAVVGEGSFSTVYLARLAGSSQ-----LAAVK-VHRSSERLRRAFRQELDALLRVRHPH 395 T +G G F V+LA+ G+ L VK + E+L+ FR+E + ++ H + Sbjct: 779 TITTLGRGEFGEVFLAKAKGAEDAEGEALVLVKSLQTRDEQLQLDFRREAEMFGKLNHVN 838 Query: 396 IVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKA---SVSP-PLPWARRAAVALQV 554 +VRLL C + + +VLE+ G L L SK+ S+ P PL + ++ QV Sbjct: 839 VVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDESLKPQPLSTKHKVSLCTQV 895
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 51.2 bits (121), Expect = 2e-06 Identities = 33/113 (29%), Positives = 56/113 (49%), Gaps = 10/113 (8%) Frame = +3 Query: 240 AVVGEGSFSTVYLARL---------AGSSQLAAVK-VHRSSERLRRAFRQELDALLRVRH 389 +++G+G F VY + GS + A+K ++ S + +R E++ L + H Sbjct: 90 SMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIKRLNSESVQGFAEWRSEVNFLGMLSH 149 Query: 390 PHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVAL 548 ++V+LL +C + E +LV EF P GSL HL + P PW R + + Sbjct: 150 RNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRR----NDPFPWDLRIKIVI 198
>KPSH2_HUMAN (Q96QS6) Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2)| Length = 385 Score = 50.8 bits (120), Expect = 3e-06 Identities = 39/118 (33%), Positives = 53/118 (44%), Gaps = 10/118 (8%) Frame = +3 Query: 168 PGKVGGARQLSWAQVEAMTAGFT---------SAVVGEGSFSTVYLARLAGSSQLAAVKV 320 PG A+ QV A F A++G GSFS V + + A+KV Sbjct: 34 PGPEAAAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKV 93 Query: 321 HRSSERL-RRAFRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHA 491 + ER R A EL L RV H +IV+L+ + D+ +V+E A G L D L A Sbjct: 94 METREREGREACVSELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIA 151
>MOS_XENLA (P12965) Serine/threonine-protein kinase mos (EC 2.7.11.1)| (pp39-mos) Length = 359 Score = 50.8 bits (120), Expect = 3e-06 Identities = 35/99 (35%), Positives = 55/99 (55%), Gaps = 8/99 (8%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERL---RRAFRQELDALLRVRHPHIVRLLAF 416 +G G F +VY A G + +A KV RS++ R++F EL+A R+RHPH+VR++A Sbjct: 69 LGSGGFGSVYRATYRGET-VALKKVKRSTKNSLASRQSFWAELNAA-RLRHPHVVRVVAA 126 Query: 417 C-----DQRDEGVLVLEFAPNGSLHDHLHASKASVSPPL 518 D G +++E+ G+LH ++ SPPL Sbjct: 127 SASCPGDPGCPGTIIMEYTGTGTLHQRIYGR----SPPL 161
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 50.8 bits (120), Expect = 3e-06 Identities = 35/122 (28%), Positives = 58/122 (47%) Frame = +3 Query: 189 RQLSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELD 368 R+ S+ ++ T F +G G TVY L +A K+ + + F+ EL Sbjct: 522 RRYSYRELVKATRKF-KVELGRGESGTVYKGVLEDDRHVAVKKLENVRQG-KEVFQAELS 579 Query: 369 ALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVAL 548 + R+ H ++VR+ FC + +LV E+ NGSL + L + ++ L W R +AL Sbjct: 580 VIGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANILFSEGGNIL--LDWEGRFNIAL 637 Query: 549 QV 554 V Sbjct: 638 GV 639
>TIE1_HUMAN (P35590) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1138 Score = 50.8 bits (120), Expect = 3e-06 Identities = 33/96 (34%), Positives = 52/96 (54%), Gaps = 5/96 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLA--GSSQLAAVKVHR--SSERLRRAFRQELDALLRV-RHPHIVRL 407 ++GEG+F V A + G AA+K+ + +SE R F EL+ L ++ HP+I+ L Sbjct: 844 LIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINL 903 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPP 515 L C R + +E+AP G+L D L S+ + P Sbjct: 904 LGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDP 939
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 50.8 bits (120), Expect = 3e-06 Identities = 28/88 (31%), Positives = 48/88 (54%), Gaps = 4/88 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS----ERLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G F VYLAR S + A+K+ S E + R+E++ ++HP+I++L Sbjct: 88 LGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYN 147 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHLHASK 497 + + L+LE+AP G L+ L S+ Sbjct: 148 YFYDQQRIYLILEYAPRGELYKELQKSR 175
>SN1L2_CHICK (Q9IA88) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 798 Score = 50.4 bits (119), Expect = 3e-06 Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 6/102 (5%) Frame = +3 Query: 198 SWAQVEAMTAGF--TSAVVGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQ 359 S AQ + GF +G+G+F+ V LAR + A+K+ L + +R Sbjct: 14 SAAQPRPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDPSNLEKIYR- 72 Query: 360 ELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHL 485 E+ + + HPHI++L + +D +V EFA NG + DHL Sbjct: 73 EVQIMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDHL 114
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 50.4 bits (119), Expect = 3e-06 Identities = 28/88 (31%), Positives = 46/88 (52%), Gaps = 4/88 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSE----RLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G F VYLA+ + + A+K SE ++ + R+E++ +RH +I+RL Sbjct: 95 LGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKNILRLYG 154 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHLHASK 497 L+LEFA G L+ HL +K Sbjct: 155 HFHDEKRIYLILEFAGRGELYQHLRRAK 182
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 50.1 bits (118), Expect = 4e-06 Identities = 30/102 (29%), Positives = 46/102 (45%), Gaps = 3/102 (2%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSS---QLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 + +G+F+ VY G + S + R F+ EL LR HP+++ +L F Sbjct: 216 ISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGF 275 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAV 542 C R + + NGSL D L S PLPW +R ++ Sbjct: 276 CAARQFHSFIYPYMANGSLQDRLQGQGG--SDPLPWPQRVSI 315
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 50.1 bits (118), Expect = 4e-06 Identities = 28/87 (32%), Positives = 47/87 (54%), Gaps = 4/87 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS----ERLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G F VYLAR S + A+K+ S E + R+E++ ++HP+I++L Sbjct: 86 LGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYN 145 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHLHAS 494 + + L+LE+AP G L+ L S Sbjct: 146 YFYDQQRIYLILEYAPRGELYKELQKS 172
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 49.3 bits (116), Expect = 7e-06 Identities = 31/97 (31%), Positives = 54/97 (55%), Gaps = 4/97 (4%) Frame = +3 Query: 237 SAVVGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQELDALLRVRHPHIVR 404 S++VG+GSF VY A S++ A+KV R+++ L+ R+E D R++HPH++ Sbjct: 7 SSLVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKN-LRRECDIQARLKHPHVIE 65 Query: 405 LLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPP 515 ++ + + + +V EFA LH +L + A P Sbjct: 66 MIESFESKTDLFVVTEFALM-DLHRYLSYNGAMGEEP 101
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 49.3 bits (116), Expect = 7e-06 Identities = 29/82 (35%), Positives = 45/82 (54%), Gaps = 2/82 (2%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS--ERLRRAFRQELDALLRVRHPHIVRLLAFC 419 +G G+F VY A+L + AVK R + + +R F QE L + HP+IV+L+ C Sbjct: 1069 IGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGIC 1128 Query: 420 DQRDEGVLVLEFAPNGSLHDHL 485 Q+ ++V+E GSL +L Sbjct: 1129 VQKQPIMIVMELVLGGSLLTYL 1150
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 48.9 bits (115), Expect = 1e-05 Identities = 29/109 (26%), Positives = 54/109 (49%), Gaps = 5/109 (4%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLR-----RAFRQELDALLRVRHPHIVRL 407 ++GEG VY + + AVK+ + ++++ + F EL+ LL HP+I+ L Sbjct: 170 LIGEGEIFEVYRVEIQNLTY--AVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILEL 227 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQV 554 A+ + ++ L+ + NG+L D L + PLPW R + + + Sbjct: 228 AAYFTETEKFCLIYPYMRNGTLFDRLQC--VGDTAPLPWHIRIGILIGI 274
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 48.9 bits (115), Expect = 1e-05 Identities = 26/75 (34%), Positives = 43/75 (57%), Gaps = 4/75 (5%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHR----SSERLRRAFRQELDALLRVRHPHIVRLLA 413 +GEGSF V LA+ G+ Q A+K+ + ++ +E+ L +RHPHI++L Sbjct: 58 LGEGSFGKVKLAQHVGTGQKVALKIINRKTLAKSDMQGRVEREISYLRLLRHPHIIKLYD 117 Query: 414 FCDQRDEGVLVLEFA 458 +DE ++V+EFA Sbjct: 118 VIKSKDEIIMVIEFA 132
>GSK3A_HUMAN (P49840) Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3| alpha) Length = 483 Score = 48.5 bits (114), Expect = 1e-05 Identities = 34/102 (33%), Positives = 55/102 (53%), Gaps = 6/102 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFC- 419 V+G GSF VY ARLA + +L A+K +R + +EL + ++ H +IVRL F Sbjct: 124 VIGNGSFGVVYQARLAETRELVAIKKVLQDKRFK---NRELQIMRKLDHCNIVRLRYFFY 180 Query: 420 ---DQRDEGV--LVLEFAPNGSLHDHLHASKASVSPPLPWAR 530 +++DE LVLE+ P H +KA ++ P+ + + Sbjct: 181 SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVK 222
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 48.5 bits (114), Expect = 1e-05 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSER----LRRAFRQELDALLRVRHPHIVRLLA 413 +G+G F VYLAR S + A+KV S+ + R+E++ +RHP+I+RL Sbjct: 146 LGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 205 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 + L+L++AP G L L Sbjct: 206 YFHDASRVYLILDYAPGGELFREL 229
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 48.5 bits (114), Expect = 1e-05 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSER----LRRAFRQELDALLRVRHPHIVRLLA 413 +G+G F VYLAR S + A+KV S+ + R+E++ +RHP+I+RL Sbjct: 146 LGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 205 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 + L+L++AP G L L Sbjct: 206 YFHDASRVYLILDYAPGGELFREL 229
>NRKA_TRYBB (Q08942) Putative serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 431 Score = 48.5 bits (114), Expect = 1e-05 Identities = 25/84 (29%), Positives = 45/84 (53%), Gaps = 3/84 (3%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKV---HRSSERLRRAFRQELDALLRVRHPHIVRLLA 413 +VG GS+ Y+A L KV + S+R +R + E+ L HP+I+R + Sbjct: 25 IVGLGSYGEAYVAESVEDGSLCVAKVMDLSKMSQRDKRYAQSEIKCLANCNHPNIIRYIE 84 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 ++ D ++V+EFA +G+L + + Sbjct: 85 DHEENDRLLIVMEFADSGNLDEQI 108
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 48.5 bits (114), Expect = 1e-05 Identities = 26/75 (34%), Positives = 43/75 (57%), Gaps = 4/75 (5%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHR----SSERLRRAFRQELDALLRVRHPHIVRLLA 413 +GEGSF V LA+ G+ Q A+K+ + ++ +E+ L +RHPHI++L Sbjct: 59 LGEGSFGKVKLAQHLGTGQKVALKIINRKTLAKSDMQGRVEREISYLRLLRHPHIIKLYD 118 Query: 414 FCDQRDEGVLVLEFA 458 +DE ++V+EFA Sbjct: 119 VIKSKDEIIMVIEFA 133
>SN1L1_HUMAN (P57059) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) Length = 783 Score = 48.5 bits (114), Expect = 1e-05 Identities = 30/99 (30%), Positives = 51/99 (51%), Gaps = 6/99 (6%) Frame = +3 Query: 207 QVEAMTAGF--TSAVVGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQELD 368 Q + + GF +G+G+F+ V LAR + A+K+ S L + +R E+ Sbjct: 18 QQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYR-EVQ 76 Query: 369 ALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHL 485 + + HPHI++L + +D +V EFA NG + D+L Sbjct: 77 LMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYL 115
>FES_HUMAN (P07332) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 822 Score = 48.1 bits (113), Expect = 2e-05 Identities = 29/87 (33%), Positives = 41/87 (47%), Gaps = 2/87 (2%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS--ERLRRAFRQELDALLRVRHPHIVRLLAFC 419 +G G+F V+ RL + L AVK R + L+ F QE L + HP+IVRL+ C Sbjct: 567 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVC 626 Query: 420 DQRDEGVLVLEFAPNGSLHDHLHASKA 500 Q+ +V+E G L A Sbjct: 627 TQKQPIYIVMELVQGGDFLTFLRTEGA 653
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 48.1 bits (113), Expect = 2e-05 Identities = 38/119 (31%), Positives = 56/119 (47%), Gaps = 16/119 (13%) Frame = +3 Query: 246 VGEGSFSTVYLARLAG-----SSQLAAVK-VHRSSERLRRAFRQELDALLRVRHPHIVRL 407 +GEG+F V+LA L AVK + +SE R+ F +E + L ++H HIVR Sbjct: 519 LGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRF 578 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLH---------ASKASVSP-PLPWARRAAVALQV 554 C + ++V E+ +G L+ L A V+P PL + AVA QV Sbjct: 579 FGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQV 637
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 48.1 bits (113), Expect = 2e-05 Identities = 27/84 (32%), Positives = 46/84 (54%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSE----RLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G F VYLAR S + A+KV ++ + R+E++ +RHP+I+RL Sbjct: 130 LGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHPNILRLYG 189 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 + L+LE+AP G+++ L Sbjct: 190 YFHDATRVYLILEYAPLGTVYREL 213
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 47.8 bits (112), Expect = 2e-05 Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 2/87 (2%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS--ERLRRAFRQELDALLRVRHPHIVRLLAFC 419 +G G+F V+ RL + L AVK R + ++ F QE L + HP+IVRL+ C Sbjct: 222 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVC 281 Query: 420 DQRDEGVLVLEFAPNGSLHDHLHASKA 500 Q+ +V+E G L A Sbjct: 282 TQKQPIYIVMELVQGGDFLTFLRTEGA 308
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC| 2.7.10.2) (C-FES) Length = 820 Score = 47.8 bits (112), Expect = 2e-05 Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 2/87 (2%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS--ERLRRAFRQELDALLRVRHPHIVRLLAFC 419 +G G+F V+ RL + L AVK R + ++ F QE L + HP+IVRL+ C Sbjct: 565 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVC 624 Query: 420 DQRDEGVLVLEFAPNGSLHDHLHASKA 500 Q+ +V+E G L A Sbjct: 625 TQKQPIYIVMELVQGGDFLTFLRTEGA 651
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 47.8 bits (112), Expect = 2e-05 Identities = 38/119 (31%), Positives = 57/119 (47%), Gaps = 16/119 (13%) Frame = +3 Query: 246 VGEGSFSTVYLARLAG-----SSQLAAVK-VHRSSERLRRAFRQELDALLRVRHPHIVRL 407 +GEG+F V+LA L AVK + +SE R+ F++E + L ++H HIVR Sbjct: 516 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRF 575 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLH---------ASKASVSP-PLPWARRAAVALQV 554 C + ++V E+ +G L+ L A V+P PL + AVA QV Sbjct: 576 FGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQV 634
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 47.8 bits (112), Expect = 2e-05 Identities = 24/83 (28%), Positives = 43/83 (51%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G GSF TV+ R G + +KV + + +AF+ E+ L + RH +I+ + F Sbjct: 316 IGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFM-T 374 Query: 426 RDEGVLVLEFAPNGSLHDHLHAS 494 R ++ ++ SL+ HLH + Sbjct: 375 RPGFAIITQWCEGSSLYHHLHVA 397
>MYLK_DICDI (P25323) Myosin light chain kinase (EC 2.7.11.18) (MLCK)| Length = 295 Score = 47.8 bits (112), Expect = 2e-05 Identities = 28/83 (33%), Positives = 42/83 (50%), Gaps = 3/83 (3%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSER---LRRAFRQELDALLRVRHPHIVRLLAF 416 +G G+FS VYL + Q A+KV SE + + E+D L +V HP+I+ L Sbjct: 14 LGRGAFSIVYLGENKQTKQRYAIKVINKSELGKDYEKNLKMEVDILKKVNHPNIIALKEL 73 Query: 417 CDQRDEGVLVLEFAPNGSLHDHL 485 D ++ LV+E G L D + Sbjct: 74 FDTPEKLYLVMELVTGGELFDKI 96
>FES_FSVGA (P00542) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 609 Score = 47.8 bits (112), Expect = 2e-05 Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 2/87 (2%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS--ERLRRAFRQELDALLRVRHPHIVRLLAFC 419 +G G+F V+ RL + L AVK R + ++ F QE L + HP+IVRL+ C Sbjct: 354 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVC 413 Query: 420 DQRDEGVLVLEFAPNGSLHDHLHASKA 500 Q+ +V+E G L A Sbjct: 414 TQKQPIYIVMELVQGGDFLTFLRTEGA 440
>IPL1_DEBHA (Q6BVA0) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 412 Score = 47.8 bits (112), Expect = 2e-05 Identities = 27/89 (30%), Positives = 45/89 (50%), Gaps = 4/89 (4%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSE----RLRRAFRQELDALLRVRHPHIVRLL 410 V+G+G VY + S +AA+KV + +L + FR+E++ + HP I RL Sbjct: 153 VLGKGKLGKVYCVKHKTSGYIAALKVMAKKDLIDLKLEKNFRREIEIQSNLIHPKISRLY 212 Query: 411 AFCDQRDEGVLVLEFAPNGSLHDHLHASK 497 F L+LE++ +G L+ HL + Sbjct: 213 GFFYDHKNVYLILEYSIHGELYHHLKVQR 241
>GSK3A_RAT (P18265) Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3| alpha) (Factor A) (FA) Length = 483 Score = 47.4 bits (111), Expect = 3e-05 Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 6/102 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFC- 419 V+G GSF VY ARLA + +L A+K +R + +EL + ++ H +IVRL F Sbjct: 124 VIGNGSFGVVYQARLAETRELVAIKKVLQDKRFK---NRELQIMRKLDHCNIVRLRYFFY 180 Query: 420 ---DQRDEGV--LVLEFAPNGSLHDHLHASKASVSPPLPWAR 530 +++DE LVLE+ P H +KA + P+ + + Sbjct: 181 SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLIIPIIYVK 222
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 47.4 bits (111), Expect = 3e-05 Identities = 27/84 (32%), Positives = 46/84 (54%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSER----LRRAFRQELDALLRVRHPHIVRLLA 413 +G+G F VYLAR S + A+KV ++ + R+E++ +RHP+I+RL Sbjct: 139 LGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 198 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 + L+LE+AP G+++ L Sbjct: 199 YFHDATRVYLILEYAPLGTVYREL 222
>LRRK2_MOUSE (Q5S006) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 2527 Score = 47.4 bits (111), Expect = 3e-05 Identities = 35/92 (38%), Positives = 48/92 (52%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCD 422 ++G+GSF +VY A G AVK+ LR RQEL L + HP ++ LLA Sbjct: 1884 LLGDGSFGSVYRAAYEGEE--VAVKIFNKHTSLR-LLRQELVVLCHLHHPSLISLLAAGI 1940 Query: 423 QRDEGVLVLEFAPNGSLHDHLHASKASVSPPL 518 + +LV+E A GSL L KAS++ L Sbjct: 1941 R--PRMLVMELASKGSLDRLLQQDKASLTRTL 1970
>LRRK2_HUMAN (Q5S007) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) (Dardarin) Length = 2527 Score = 47.4 bits (111), Expect = 3e-05 Identities = 35/92 (38%), Positives = 48/92 (52%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCD 422 ++G+GSF +VY A G AVK+ LR RQEL L + HP ++ LLA Sbjct: 1884 LLGDGSFGSVYRAAYEGEE--VAVKIFNKHTSLR-LLRQELVVLCHLHHPSLISLLAAGI 1940 Query: 423 QRDEGVLVLEFAPNGSLHDHLHASKASVSPPL 518 + +LV+E A GSL L KAS++ L Sbjct: 1941 R--PRMLVMELASKGSLDRLLQQDKASLTRTL 1970
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 47.4 bits (111), Expect = 3e-05 Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G F VYLAR S + A+KV + R+E++ +RHP+I+RL Sbjct: 132 LGKGKFGNVYLAREKQSKFILALKVLFKVQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 191 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 + L+LE+AP G+++ L Sbjct: 192 YFHDATRVYLILEYAPLGTVYREL 215
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 47.4 bits (111), Expect = 3e-05 Identities = 24/83 (28%), Positives = 43/83 (51%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G GSF TV+ R G + +KV + + +AF+ E+ L + RH +I+ + F Sbjct: 316 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFM-T 374 Query: 426 RDEGVLVLEFAPNGSLHDHLHAS 494 R ++ ++ SL+ HLH + Sbjct: 375 RPGFAIITQWCEGSSLYHHLHVA 397
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 47.4 bits (111), Expect = 3e-05 Identities = 26/87 (29%), Positives = 44/87 (50%) Frame = +3 Query: 237 SAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 S +G GSF TVY + G + +KV + +AFR E+ L + RH +I+ + + Sbjct: 352 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 411 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASK 497 +D +V ++ SL+ HLH + Sbjct: 412 M-TKDNLAIVTQWCEGSSLYKHLHVQE 437
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 47.4 bits (111), Expect = 3e-05 Identities = 26/87 (29%), Positives = 44/87 (50%) Frame = +3 Query: 237 SAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 S +G GSF TVY + G + +KV + +AFR E+ L + RH +I+ + + Sbjct: 352 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 411 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASK 497 +D +V ++ SL+ HLH + Sbjct: 412 M-TKDNLAIVTQWCEGSSLYKHLHVQE 437
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 47.4 bits (111), Expect = 3e-05 Identities = 24/83 (28%), Positives = 43/83 (51%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G GSF TV+ R G + +KV + + +AF+ E+ L + RH +I+ + F Sbjct: 314 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFM-T 372 Query: 426 RDEGVLVLEFAPNGSLHDHLHAS 494 R ++ ++ SL+ HLH + Sbjct: 373 RPGFAIITQWCEGSSLYHHLHVA 395
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 47.4 bits (111), Expect = 3e-05 Identities = 24/83 (28%), Positives = 43/83 (51%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G GSF TV+ R G + +KV + + +AF+ E+ L + RH +I+ + F Sbjct: 314 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFM-T 372 Query: 426 RDEGVLVLEFAPNGSLHDHLHAS 494 R ++ ++ SL+ HLH + Sbjct: 373 RPGFAIITQWCEGSSLYHHLHVA 395
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 47.4 bits (111), Expect = 3e-05 Identities = 26/87 (29%), Positives = 44/87 (50%) Frame = +3 Query: 237 SAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 S +G GSF TVY + G + +KV + +AFR E+ L + RH +I+ + + Sbjct: 27 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 86 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASK 497 +D +V ++ SL+ HLH + Sbjct: 87 M-TKDNLAIVTQWCEGSSLYKHLHVQE 112
>PKN2_HUMAN (Q16513) Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein| kinase C-like 2) (Protein-kinase C-related kinase 2) Length = 984 Score = 47.4 bits (111), Expect = 3e-05 Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 10/114 (8%) Frame = +3 Query: 240 AVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALL----------RVRH 389 AV+G G F V LA ++++ A+K + + + R E+D+L+ VRH Sbjct: 661 AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVAR---DEVDSLMCEKRIFETVNSVRH 717 Query: 390 PHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQ 551 P +V L A ++ V+E+A G L H+H S + +A + LQ Sbjct: 718 PFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQ 771
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 47.0 bits (110), Expect = 4e-05 Identities = 26/87 (29%), Positives = 44/87 (50%) Frame = +3 Query: 237 SAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 S +G GSF TVY + G + +KV + +AFR E+ L + RH +I+ + + Sbjct: 85 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 144 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASK 497 +D +V ++ SL+ HLH + Sbjct: 145 M-TKDNLAIVTQWCEGSSLYKHLHVQE 170
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 47.0 bits (110), Expect = 4e-05 Identities = 26/84 (30%), Positives = 44/84 (52%) Frame = +3 Query: 237 SAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 S+ +G GSF TVY + G + +KV + +AFR E+ L + RH +I+ + + Sbjct: 343 SSRIGSGSFGTVYKGKWHGDVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 402 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLH 488 +D +V ++ SL+ HLH Sbjct: 403 M-TKDNLAIVTQWCEGSSLYYHLH 425
>PTK7_HUMAN (Q13308) Tyrosine-protein kinase-like 7 precursor (Colon carcinoma| kinase 4) (CCK-4) Length = 1070 Score = 47.0 bits (110), Expect = 4e-05 Identities = 33/113 (29%), Positives = 56/113 (49%), Gaps = 10/113 (8%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQ-----LAAVKVHRSSERLRRA-FRQELDALLRVRHPHIVRL 407 +G+ F V+LA+ G + L VK +S + ++ FR+EL+ ++ H ++VRL Sbjct: 802 LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRL 861 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLHASKAS----VSPPLPWARRAAVALQV 554 L C + + +VLE+ L L SK+ S PL ++ A+ QV Sbjct: 862 LGLCREAEPHYMVLEYVDLEDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQV 914
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 47.0 bits (110), Expect = 4e-05 Identities = 26/87 (29%), Positives = 44/87 (50%) Frame = +3 Query: 237 SAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 S +G GSF TVY + G + +KV + +AFR E+ L + RH +I+ + + Sbjct: 352 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 411 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASK 497 +D +V ++ SL+ HLH + Sbjct: 412 M-TKDNLAIVTQWCEGSSLYKHLHVQE 437
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 47.0 bits (110), Expect = 4e-05 Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 4/85 (4%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSE----RLRRAFRQELDALLRVRHPHIVRLL 410 V+G+G F VY R S + A+K + + + FR+E++ +RHP++ +L Sbjct: 114 VLGKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQFRREVEIQSSLRHPNLTQLY 173 Query: 411 AFCDQRDEGVLVLEFAPNGSLHDHL 485 + L++E+ NG L+ HL Sbjct: 174 GYFHDEKRVYLLMEYLVNGELYKHL 198
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 47.0 bits (110), Expect = 4e-05 Identities = 26/87 (29%), Positives = 44/87 (50%) Frame = +3 Query: 237 SAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 S +G GSF TVY + G + +KV + +AFR E+ L + RH +I+ + + Sbjct: 352 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 411 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASK 497 +D +V ++ SL+ HLH + Sbjct: 412 M-TKDNLAIVTQWCEGSSLYKHLHVQE 437
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 47.0 bits (110), Expect = 4e-05 Identities = 29/84 (34%), Positives = 44/84 (52%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSE----RLRRAFRQELDALLRVRHPHIVRLLA 413 +G G F VYLARL + + A+KV SE L R+E++ ++H +I+RL Sbjct: 22 LGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRNILRLYN 81 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 + L+LE+AP G L+ L Sbjct: 82 YFYDDTRIYLILEYAPGGELYKEL 105
>PKN2_RAT (O08874) Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein| kinase C-like 2) (Protein-kinase C-related kinase 2) (Protease-activated kinase 2) (PAK-2) (Fragment) Length = 842 Score = 46.6 bits (109), Expect = 5e-05 Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 10/114 (8%) Frame = +3 Query: 240 AVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALL----------RVRH 389 AV+G G F V LA ++++ A+K + + + R E+D+L+ VRH Sbjct: 525 AVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVAR---DEVDSLMCEKRIFETVNSVRH 581 Query: 390 PHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQ 551 P +V L A ++ V+E+A G L H+H S + +A + LQ Sbjct: 582 PFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQ 635
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 46.6 bits (109), Expect = 5e-05 Identities = 30/103 (29%), Positives = 49/103 (47%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G FS VY R S Q+ +K+++ R E+ + R+RHP+I+R + C Sbjct: 58 IGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNTLR-EVQLMNRLRHPNILRFMGVCVH 116 Query: 426 RDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQV 554 + + + E+ G+L L S PL W R +AL + Sbjct: 117 QGQLHALTEYMNGGTLEQLL-----SSPEPLSWPVRLHLALDI 154
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 46.6 bits (109), Expect = 5e-05 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 2/84 (2%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS--ERLRRAFRQELDALLRVRHPHIVRLLAFC 419 +G G+F V+ RL + AVK R + L+ F QE L + HP+IVRL+ C Sbjct: 618 IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQCNHPNIVRLIGVC 677 Query: 420 DQRDEGVLVLEFAPNGSLHDHLHA 491 Q+ +V+E G L + Sbjct: 678 TQKQPIYIVMELVQGGDFLSFLRS 701
>PKN2_MOUSE (Q8BWW9) Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein| kinase C-like 2) (Protein-kinase C-related kinase 2) Length = 983 Score = 46.6 bits (109), Expect = 5e-05 Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 10/114 (8%) Frame = +3 Query: 240 AVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALL----------RVRH 389 AV+G G F V LA ++++ A+K + + + R E+D+L+ VRH Sbjct: 660 AVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVAR---DEVDSLMCEKRIFETVNSVRH 716 Query: 390 PHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQ 551 P +V L A ++ V+E+A G L H+H S + +A + LQ Sbjct: 717 PFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQ 770
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 46.6 bits (109), Expect = 5e-05 Identities = 30/103 (29%), Positives = 49/103 (47%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G FS VY R S Q+ +K+++ R E+ + R+RHP+I+R + C Sbjct: 58 IGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNTLR-EVQLMNRLRHPNILRFMGVCVH 116 Query: 426 RDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQV 554 + + + E+ G+L L S PL W R +AL + Sbjct: 117 QGQLHALTEYMNGGTLEQLL-----SSPEPLSWPVRLHLALDI 154
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 46.6 bits (109), Expect = 5e-05 Identities = 27/90 (30%), Positives = 43/90 (47%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G F VY L +S AVK ++ AF E + ++RHP +++L A C Q Sbjct: 101 LGAGQFGEVYQG-LWNNSTPVAVKTLKAGTMQPAAFLAEAQIMKKLRHPKLIQLYAVCTQ 159 Query: 426 RDEGVLVLEFAPNGSLHDHLHASKASVSPP 515 + ++ E GSL D+L ++ P Sbjct: 160 GEPVYIITELMSKGSLLDYLQGEAGALKLP 189
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 46.6 bits (109), Expect = 5e-05 Identities = 30/107 (28%), Positives = 55/107 (51%), Gaps = 4/107 (3%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQELDALLRVRHPHIVRLLA 413 VGEG S VY AR ++ AVK+ +++E + R F++E A+ + +P++V +L Sbjct: 16 VGEGGMSFVYKARCRKLNRFVAVKILKDEFKNNEEIVRRFKKEATAIANLSNPNVVNVLD 75 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQV 554 Q D +V+E+ +L D + A LP+ ++ ++V Sbjct: 76 VGTQDDINYIVMEYVEGKTLKDIIKEKGA-----LPYEVAISIGIKV 117
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 46.6 bits (109), Expect = 5e-05 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 2/84 (2%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS--ERLRRAFRQELDALLRVRHPHIVRLLAFC 419 +G G+F V+ RL + AVK R + L+ F QE L + HP+IVRL+ C Sbjct: 278 IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQYNHPNIVRLIGVC 337 Query: 420 DQRDEGVLVLEFAPNGSLHDHLHA 491 Q+ +V+E G L + Sbjct: 338 TQKQPIYIVMELVQGGDFLSFLRS 361
>DDR2_MOUSE (Q62371) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 854 Score = 46.2 bits (108), Expect = 6e-05 Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 22/125 (17%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQ----------------LAAVKVHRS--SERLRRAFRQELDA 371 +GEG F V+L + G + L AVK+ R+ ++ R F +E+ Sbjct: 569 LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKI 628 Query: 372 LLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHD----HLHASKASVSPPLPWARRAA 539 + R++ P+I+RLLA C D ++ E+ NG L+ H S S + +A Sbjct: 629 MSRLKDPNIIRLLAVCITEDPLCMITEYMENGDLNQFLSRHEPLSSCSSDATVSYANLKF 688 Query: 540 VALQV 554 +A Q+ Sbjct: 689 MATQI 693
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 46.2 bits (108), Expect = 6e-05 Identities = 30/103 (29%), Positives = 49/103 (47%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G FS VY R S Q+ +K+++ R E+ + R+RHP+I+R + C Sbjct: 63 IGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLR-EVQLMNRLRHPNILRFMGVCVH 121 Query: 426 RDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQV 554 + + + E+ G+L L S PL W R +AL + Sbjct: 122 QGQLHALTEYMNGGTLEQLL-----SSPEPLSWPVRLHLALDI 159
>SN1L1_MOUSE (Q60670) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1-like kinase) Length = 779 Score = 46.2 bits (108), Expect = 6e-05 Identities = 29/99 (29%), Positives = 51/99 (51%), Gaps = 6/99 (6%) Frame = +3 Query: 207 QVEAMTAGF--TSAVVGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQELD 368 Q + + GF +G+G+F+ V LAR + A+K+ S L + +R E+ Sbjct: 18 QQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYR-EVQ 76 Query: 369 ALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHL 485 + + HP+I++L + +D +V EFA NG + D+L Sbjct: 77 LMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYL 115
>RAD53_YEAST (P22216) Serine/threonine-protein kinase RAD53 (EC 2.7.11.1)| (Serine-protein kinase 1) Length = 821 Score = 46.2 bits (108), Expect = 6e-05 Identities = 29/88 (32%), Positives = 46/88 (52%), Gaps = 2/88 (2%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRR--AFRQELDALLRVRHPHIVRLLAF 416 VVG+G+F+TV A + + AVK+ + + +EL+ L ++ HP IVRL F Sbjct: 203 VVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGF 262 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASKA 500 + + +V+EF G L D + A A Sbjct: 263 YEDTESYYMVMEFVSGGDLMDFVAAHGA 290
>SN1L1_RAT (Q9R1U5) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (Salt-inducible protein kinase) (Protein kinase KID2) Length = 776 Score = 46.2 bits (108), Expect = 6e-05 Identities = 29/99 (29%), Positives = 51/99 (51%), Gaps = 6/99 (6%) Frame = +3 Query: 207 QVEAMTAGF--TSAVVGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQELD 368 Q + + GF +G+G+F+ V LAR + A+K+ S L + +R E+ Sbjct: 18 QQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYR-EVQ 76 Query: 369 ALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHL 485 + + HP+I++L + +D +V EFA NG + D+L Sbjct: 77 LMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYL 115
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 45.8 bits (107), Expect = 8e-05 Identities = 27/84 (32%), Positives = 46/84 (54%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHR----SSERLRRAFRQELDALLRVRHPHIVRLLA 413 +GEGSF V LA + Q A+K+ + ++ +E+ L +RHPHI++L Sbjct: 45 LGEGSFGKVKLAYHVTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYD 104 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 +DE ++V+E+A N L D++ Sbjct: 105 VIKSKDEIIMVIEYAGN-ELFDYI 127
>RET_MOUSE (P35546) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1115 Score = 45.8 bits (107), Expect = 8e-05 Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 7/91 (7%) Frame = +3 Query: 246 VGEGSFSTVYLA---RLAGSSQLAAVKV----HRSSERLRRAFRQELDALLRVRHPHIVR 404 +GEG F V A RL G + V V +S+ R E + L +V HPH+++ Sbjct: 731 LGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIK 790 Query: 405 LLAFCDQRDEGVLVLEFAPNGSLHDHLHASK 497 L C Q +L++E+A GSL L S+ Sbjct: 791 LYGACSQDGPLLLIVEYAKYGSLRGFLRDSR 821
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 820 Score = 45.8 bits (107), Expect = 8e-05 Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 2/87 (2%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS--ERLRRAFRQELDALLRVRHPHIVRLLAFC 419 +G G+F V+ RL + AVK R + L+ F QE L + HP+IVRL+ C Sbjct: 565 IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVC 624 Query: 420 DQRDEGVLVLEFAPNGSLHDHLHASKA 500 Q+ +V+E G L A Sbjct: 625 TQKQPIYIVMELVQGGDFLTFLRTEGA 651
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 45.8 bits (107), Expect = 8e-05 Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAF----RQELDALLRVRHPHIVRLLA 413 +GEG+F+ V AR + A+K+ S L+ ++E+ + VRHP+IVRL Sbjct: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 + +VLEF G L D + Sbjct: 77 VLASPSKIYIVLEFVTGGELFDRI 100
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 45.8 bits (107), Expect = 8e-05 Identities = 30/86 (34%), Positives = 46/86 (53%), Gaps = 9/86 (10%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVK-----VHRSSERLRRAFRQELDA----LLRVRHPH 395 ++G G+F TVY+ S +L AVK + +S+ +A QEL+ L + HP+ Sbjct: 74 LIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPN 133 Query: 396 IVRLLAFCDQRDEGVLVLEFAPNGSL 473 IVR L + D ++LEF P GS+ Sbjct: 134 IVRYLGTVREDDTLNILLEFVPGGSI 159
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 45.8 bits (107), Expect = 8e-05 Identities = 32/106 (30%), Positives = 46/106 (43%), Gaps = 5/106 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV-----HRSSERLRRAFRQELDALLRVRHPHIVRLL 410 +G G VYL + A+KV H + R F++E L V HP +VR++ Sbjct: 19 LGSGGMGEVYLGEQVSLGRKVAIKVLHHDLHAQAGMAER-FKREARLLSAVEHPAVVRIV 77 Query: 411 AFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVAL 548 F + D LV+EF SL+D L LP ++ A L Sbjct: 78 DFGESGDHACLVMEFVEGESLYDVLTPGPMPPGRALPLLQQLAEGL 123
>SNF1_YEAST (P06782) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 633 Score = 45.8 bits (107), Expect = 8e-05 Identities = 27/84 (32%), Positives = 46/84 (54%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHR----SSERLRRAFRQELDALLRVRHPHIVRLLA 413 +GEGSF V LA + Q A+K+ + ++ +E+ L +RHPHI++L Sbjct: 61 LGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYD 120 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 +DE ++V+E+A N L D++ Sbjct: 121 VIKSKDEIIMVIEYAGN-ELFDYI 143
>PSK1_SCHPO (Q12706) Serine/threonine-protein kinase psk1 (EC 2.7.11.22)| Length = 436 Score = 45.8 bits (107), Expect = 8e-05 Identities = 29/86 (33%), Positives = 41/86 (47%), Gaps = 5/86 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRA-----FRQELDALLRVRHPHIVRL 407 V+G GS+ V L + + +L A K + + + RA + E L VRHP I RL Sbjct: 96 VLGRGSYGKVLLVKQKNTGRLFAQKQLKKASIVLRAKGLEQTKNERQILEEVRHPFICRL 155 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHL 485 D L+L++AP G L HL Sbjct: 156 YYAFQDHDRLYLILQYAPGGELFSHL 181
>GSK3B_RAT (P18266) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) (Factor A) (FA) Length = 420 Score = 45.4 bits (106), Expect = 1e-04 Identities = 32/102 (31%), Positives = 53/102 (51%), Gaps = 6/102 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFC- 419 V+G GSF VY A+L S +L A+K +R + +EL + ++ H +IVRL F Sbjct: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK---NRELQIMRKLDHCNIVRLRYFFY 117 Query: 420 ---DQRDEGV--LVLEFAPNGSLHDHLHASKASVSPPLPWAR 530 +++DE LVL++ P H S+A + P+ + + Sbjct: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159
>GSK3B_MOUSE (Q9WV60) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 45.4 bits (106), Expect = 1e-04 Identities = 32/102 (31%), Positives = 53/102 (51%), Gaps = 6/102 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFC- 419 V+G GSF VY A+L S +L A+K +R + +EL + ++ H +IVRL F Sbjct: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK---NRELQIMRKLDHCNIVRLRYFFY 117 Query: 420 ---DQRDEGV--LVLEFAPNGSLHDHLHASKASVSPPLPWAR 530 +++DE LVL++ P H S+A + P+ + + Sbjct: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159
>GSK3B_HUMAN (P49841) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 45.4 bits (106), Expect = 1e-04 Identities = 32/102 (31%), Positives = 53/102 (51%), Gaps = 6/102 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFC- 419 V+G GSF VY A+L S +L A+K +R + +EL + ++ H +IVRL F Sbjct: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK---NRELQIMRKLDHCNIVRLRYFFY 117 Query: 420 ---DQRDEGV--LVLEFAPNGSLHDHLHASKASVSPPLPWAR 530 +++DE LVL++ P H S+A + P+ + + Sbjct: 118 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 159
>KCC2_SCHPO (O42844) Calcium/calmodulin-dependent protein kinase type II (EC| 2.7.11.17) (CAM kinase II) Length = 504 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/79 (35%), Positives = 43/79 (54%), Gaps = 3/79 (3%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSE---RLRRAFRQELDALLRVRHPHIVRLLAF 416 +G+G+FS VY A + AVKV R E + R+ +E++ + RV+H ++V L F Sbjct: 71 LGDGAFSQVYKAYSIDRKEHVAVKVIRKYEMNKKQRQGVFKEVNIMRRVKHKNVVNLFDF 130 Query: 417 CDQRDEGVLVLEFAPNGSL 473 + D LV+E A G L Sbjct: 131 VETEDFYHLVMELAEGGEL 149
>KPSH1_MOUSE (Q91YA2) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/85 (32%), Positives = 44/85 (51%), Gaps = 1/85 (1%) Frame = +3 Query: 240 AVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERL-RRAFRQELDALLRVRHPHIVRLLAF 416 A++G GSFS V + Q A+K+ + R R EL L RVRH +I++L+ Sbjct: 101 ALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEV 160 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHA 491 + ++ +V+E A G L D + A Sbjct: 161 FETQERVYMVMELATGGELFDRIIA 185
>KPSH1_HUMAN (P11801) Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1)| Length = 423 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/85 (32%), Positives = 44/85 (51%), Gaps = 1/85 (1%) Frame = +3 Query: 240 AVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERL-RRAFRQELDALLRVRHPHIVRLLAF 416 A++G GSFS V + Q A+K+ + R R EL L RVRH +I++L+ Sbjct: 101 ALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEV 160 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHA 491 + ++ +V+E A G L D + A Sbjct: 161 FETQERVYMVMELATGGELFDRIIA 185
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 45.4 bits (106), Expect = 1e-04 Identities = 31/104 (29%), Positives = 54/104 (51%), Gaps = 8/104 (7%) Frame = +3 Query: 246 VGEGSFSTV----YLARLAGSSQLAAVKVHRSS--ERLRRAFRQELDALLRVRHPHIVRL 407 +GEG F V Y G+ ++ AVK ++ + R ++QE+D L + H HI++ Sbjct: 903 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKY 962 Query: 408 LAFCDQRDEG--VLVLEFAPNGSLHDHLHASKASVSPPLPWARR 533 C+ + E LV+E+ P GSL D+L ++ L +A++ Sbjct: 963 KGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQ 1006
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 45.4 bits (106), Expect = 1e-04 Identities = 27/87 (31%), Positives = 43/87 (49%), Gaps = 2/87 (2%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSS--ERLRRAFRQELDALLRVRHPHIVRLLAF 416 ++G+G+F VY L + +A VK + + L+ F QE L + HP+IV+L+ Sbjct: 69 LLGKGNFGEVYKGTLKDKTPVA-VKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGV 127 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASK 497 C QR +++E P G L K Sbjct: 128 CTQRQPVYIIMELVPGGDFLSFLRKRK 154
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 45.4 bits (106), Expect = 1e-04 Identities = 26/84 (30%), Positives = 42/84 (50%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G GSF TVY A G + + V S +AF+ E+ L + RH +I+ L C Sbjct: 435 IGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNIL-LFMGCVS 493 Query: 426 RDEGVLVLEFAPNGSLHDHLHASK 497 + +V ++ SL+ H+H S+ Sbjct: 494 KPSLAIVTQWCEGSSLYKHVHVSE 517
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 45.1 bits (105), Expect = 1e-04 Identities = 27/76 (35%), Positives = 46/76 (60%), Gaps = 4/76 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVK----VHRSSERLRRAFRQELDALLRVRHPHIVRLL 410 ++GEGSF VY R S+Q+ A+K + RS + LR ++E++ + +RHP+IV +L Sbjct: 9 MIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRN-LQREIEIMRGLRHPNIVHML 67 Query: 411 AFCDQRDEGVLVLEFA 458 + E V+V ++A Sbjct: 68 DSFETDKEVVVVTDYA 83
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 45.1 bits (105), Expect = 1e-04 Identities = 27/76 (35%), Positives = 46/76 (60%), Gaps = 4/76 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVK----VHRSSERLRRAFRQELDALLRVRHPHIVRLL 410 ++GEGSF VY R S+Q+ A+K + RS + LR ++E++ + +RHP+IV +L Sbjct: 9 MIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRN-LQREIEIMRGLRHPNIVHML 67 Query: 411 AFCDQRDEGVLVLEFA 458 + E V+V ++A Sbjct: 68 DSFETDKEVVVVTDYA 83
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 45.1 bits (105), Expect = 1e-04 Identities = 27/84 (32%), Positives = 45/84 (53%), Gaps = 7/84 (8%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKV-------HRSSERLRRAFRQELDALLRVRHPHIV 401 ++G+G++ TVY L QL AVK ++E+ R ++E+D L ++H +IV Sbjct: 1066 ILGKGAYGTVYCG-LTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 1124 Query: 402 RLLAFCDQRDEGVLVLEFAPNGSL 473 L C Q + + +EF P GS+ Sbjct: 1125 AYLGTCLQENTVSIFMEFVPGGSI 1148
>M4K2_MOUSE (Q61161) Mitogen-activated protein kinase kinase kinase kinase 2| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein) Length = 821 Score = 45.1 bits (105), Expect = 1e-04 Identities = 28/84 (33%), Positives = 45/84 (53%), Gaps = 1/84 (1%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLR-RAFRQELDALLRVRHPHIVRLLAFCD 422 VG G++ VY AR +S+LAAVK+ + + +QE+ L RHP++V + Sbjct: 22 VGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYL 81 Query: 423 QRDEGVLVLEFAPNGSLHDHLHAS 494 + D + +EF GSL + HA+ Sbjct: 82 RNDRLWICMEFCGGGSLQEIYHAT 105
>IKKE_HUMAN (Q14164) Inhibitor of nuclear factor kappa-B kinase epsilon subunit| (EC 2.7.11.1) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK-E) (Inducible I kappa-B kinase) (IKK-i) Length = 716 Score = 45.1 bits (105), Expect = 1e-04 Identities = 32/98 (32%), Positives = 54/98 (55%), Gaps = 4/98 (4%) Frame = +3 Query: 234 TSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQ--ELDALLRVRHPHIVRL 407 T ++G+G+ ++VY AR S +L AVKV ++ LR Q E + L ++ H +IV+L Sbjct: 11 TDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIVKL 70 Query: 408 LAFCDQ--RDEGVLVLEFAPNGSLHDHLHASKASVSPP 515 A + + VLV+E+ +GSL L + + + P Sbjct: 71 FAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLP 108
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 45.1 bits (105), Expect = 1e-04 Identities = 33/105 (31%), Positives = 52/105 (49%), Gaps = 2/105 (1%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRS--SERLRRAFRQELDALLRVRHPHIVRLLAFC 419 +G GSF TV+ A GS + + + +ER+ F +E+ + R+RHP+IV + Sbjct: 557 IGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNE-FLREVAIMKRLRHPNIVLFMGAV 615 Query: 420 DQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQV 554 Q +V E+ GSL+ LH K+ L RR ++A V Sbjct: 616 TQPPNLSIVTEYLSRGSLYRLLH--KSGAREQLDERRRLSMAYDV 658
>M4K2_HUMAN (Q12851) Mitogen-activated protein kinase kinase kinase kinase 2| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-pro Length = 819 Score = 45.1 bits (105), Expect = 1e-04 Identities = 28/84 (33%), Positives = 45/84 (53%), Gaps = 1/84 (1%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLR-RAFRQELDALLRVRHPHIVRLLAFCD 422 VG G++ VY AR +S+LAAVK+ + + +QE+ L RHP++V + Sbjct: 21 VGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYL 80 Query: 423 QRDEGVLVLEFAPNGSLHDHLHAS 494 + D + +EF GSL + HA+ Sbjct: 81 RNDRLWICMEFCGGGSLQEIYHAT 104
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 45.1 bits (105), Expect = 1e-04 Identities = 31/88 (35%), Positives = 49/88 (55%), Gaps = 8/88 (9%) Frame = +3 Query: 246 VGEGSFSTV----YLARLAGSSQLAAVKVHRSS--ERLRRAFRQELDALLRVRHPHIVRL 407 +GEG F V Y G+ ++ AVK + +LR +++E++ L + H HIV+ Sbjct: 896 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKY 955 Query: 408 LAFC-DQRDEGV-LVLEFAPNGSLHDHL 485 C DQ ++ V LV+E+ P GSL D+L Sbjct: 956 KGCCEDQGEKSVQLVMEYVPLGSLRDYL 983
>DDR1_PANTR (Q7YR43) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (CD167a antigen) Length = 909 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/100 (29%), Positives = 48/100 (48%), Gaps = 18/100 (18%) Frame = +3 Query: 246 VGEGSFSTVYLARL----------------AGSSQLAAVKVHR--SSERLRRAFRQELDA 371 +GEG F V+L + G L AVK+ R +++ R F +E+ Sbjct: 612 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKI 671 Query: 372 LLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHA 491 + R++ P+I+RLL C Q D ++ ++ NG L+ L A Sbjct: 672 MSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSA 711
>DDR1_MOUSE (Q03146) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protei Length = 911 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/100 (29%), Positives = 48/100 (48%), Gaps = 18/100 (18%) Frame = +3 Query: 246 VGEGSFSTVYLARLA----------------GSSQLAAVKVHR--SSERLRRAFRQELDA 371 +GEG F V+L + G L AVK+ R +++ R F +E+ Sbjct: 614 LGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKI 673 Query: 372 LLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHA 491 + R++ P+I+RLL C Q D ++ ++ NG L+ L A Sbjct: 674 MSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSA 713
>DDR1_HUMAN (Q08345) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) Length = 913 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/100 (29%), Positives = 48/100 (48%), Gaps = 18/100 (18%) Frame = +3 Query: 246 VGEGSFSTVYLARL----------------AGSSQLAAVKVHR--SSERLRRAFRQELDA 371 +GEG F V+L + G L AVK+ R +++ R F +E+ Sbjct: 616 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKI 675 Query: 372 LLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHA 491 + R++ P+I+RLL C Q D ++ ++ NG L+ L A Sbjct: 676 MSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSA 715
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 44.7 bits (104), Expect = 2e-04 Identities = 36/123 (29%), Positives = 63/123 (51%), Gaps = 8/123 (6%) Frame = +3 Query: 168 PGKVGGARQLSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLR- 344 P G R+L+W ++ + G G F +VY A G +A +V++ ++ LR Sbjct: 75 PRAPGLPRRLAWFSIDWEQVCLMHRL-GSGGFGSVYKATYHGVP-VAIKQVNKCTKDLRA 132 Query: 345 --RAFRQELDALLRVRHPHIVRLLAFCDQRDE-----GVLVLEFAPNGSLHDHLHASKAS 503 R+F EL+ + R+RH +IVR++A + E G +++EF N +LH ++ + S Sbjct: 133 SQRSFWAELN-IARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRS 191 Query: 504 VSP 512 P Sbjct: 192 PEP 194
>MOS_MOUSE (P00536) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 390 Score = 44.7 bits (104), Expect = 2e-04 Identities = 36/123 (29%), Positives = 63/123 (51%), Gaps = 8/123 (6%) Frame = +3 Query: 168 PGKVGGARQLSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLR- 344 P G R+L+W ++ + G G F +VY A G +A +V++ ++ LR Sbjct: 91 PRAPGLPRRLAWFSIDWEQVCLMHRL-GSGGFGSVYKATYHGVP-VAIKQVNKCTKDLRA 148 Query: 345 --RAFRQELDALLRVRHPHIVRLLAFCDQRDE-----GVLVLEFAPNGSLHDHLHASKAS 503 R+F EL+ + R+RH +IVR++A + E G +++EF N +LH ++ + S Sbjct: 149 SQRSFWAELN-IARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRS 207 Query: 504 VSP 512 P Sbjct: 208 PEP 210
>MOS_MSVTS (P10421) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 342 Score = 44.7 bits (104), Expect = 2e-04 Identities = 36/123 (29%), Positives = 63/123 (51%), Gaps = 8/123 (6%) Frame = +3 Query: 168 PGKVGGARQLSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLR- 344 P G R+L+W ++ + G G F +VY A G +A +V++ ++ LR Sbjct: 44 PRAPGLPRRLAWFSIDWEQVCLMHRL-GSGGFGSVYKATYHGVP-VAIKQVNKCTKDLRA 101 Query: 345 --RAFRQELDALLRVRHPHIVRLLAFCDQRDE-----GVLVLEFAPNGSLHDHLHASKAS 503 R+F EL+ + R+RH +IVR++A + E G +++EF N +LH ++ + S Sbjct: 102 SQRSFWAELN-IARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRS 160 Query: 504 VSP 512 P Sbjct: 161 PEP 163
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 44.7 bits (104), Expect = 2e-04 Identities = 26/83 (31%), Positives = 46/83 (55%), Gaps = 3/83 (3%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV---HRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 +G G F+ V LA + ++ A+K+ + L R + E+DAL +RH HI +L Sbjct: 17 IGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRV-KTEIDALKSLRHQHICQLYHV 75 Query: 417 CDQRDEGVLVLEFAPNGSLHDHL 485 + +++ +VLE+ P G L D++ Sbjct: 76 LETKNKIFMVLEYCPGGELFDYI 98
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 44.7 bits (104), Expect = 2e-04 Identities = 25/80 (31%), Positives = 41/80 (51%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G F V+ ++Q+A VK + +F E + ++RH H+V+L A C Sbjct: 246 LGAGQFGEVWAGVWNNTTQVA-VKTLKPGTMSPASFLDEAGVMKKLRHKHLVQLYAICSD 304 Query: 426 RDEGVLVLEFAPNGSLHDHL 485 R+ +V E+ GSL D+L Sbjct: 305 REPIYIVTEYMSGGSLLDYL 324
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 44.7 bits (104), Expect = 2e-04 Identities = 36/123 (29%), Positives = 63/123 (51%), Gaps = 8/123 (6%) Frame = +3 Query: 168 PGKVGGARQLSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLR- 344 P G R+L+W ++ + G G F +VY A G +A +V++ ++ LR Sbjct: 75 PRAPGLPRRLAWFSIDWEQVCLMHRL-GSGGFGSVYKATYHGVP-VAIKQVNKCTKDLRA 132 Query: 345 --RAFRQELDALLRVRHPHIVRLLAFCDQRDE-----GVLVLEFAPNGSLHDHLHASKAS 503 R+F EL+ + R+RH +IVR++A + E G +++EF N +LH ++ + S Sbjct: 133 SQRSFWAELN-IARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRS 191 Query: 504 VSP 512 P Sbjct: 192 PEP 194
>KCC4_HUMAN (Q16566) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 473 Score = 44.3 bits (103), Expect = 2e-04 Identities = 26/80 (32%), Positives = 43/80 (53%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G+ S VY + G+ + A+KV + + ++ R E+ LLR+ HP+I++L + Sbjct: 52 LGRGATSIVYRCKQKGTQKPYALKVLKKTVD-KKIVRTEIGVLLRLSHPNIIKLKEIFET 110 Query: 426 RDEGVLVLEFAPNGSLHDHL 485 E LVLE G L D + Sbjct: 111 PTEISLVLELVTGGELFDRI 130
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 44.3 bits (103), Expect = 2e-04 Identities = 22/84 (26%), Positives = 47/84 (55%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS----ERLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G++ V A S ++ A+K R E+ R+E++ + + HPHI+ + Sbjct: 61 LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYE 120 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 + +D+ V+++E+A G L+D++ Sbjct: 121 VFENKDKIVIIMEYASKGELYDYI 144
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 44.3 bits (103), Expect = 2e-04 Identities = 24/88 (27%), Positives = 45/88 (51%), Gaps = 4/88 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSE----RLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G F VYL + + ++A+K E + + FR+E++ +RH +++RL Sbjct: 105 LGKGKFGKVYLVKDKKTGFVSALKCMEKKELVEGNVEKQFRREVEIQSNLRHTNVLRLFG 164 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHLHASK 497 +D L+LE+ +G L+ L K Sbjct: 165 HFHDKDRVYLILEYVVHGELYKLLRNQK 192
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 44.3 bits (103), Expect = 2e-04 Identities = 23/84 (27%), Positives = 41/84 (48%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G F V+L ++A +K R F +E + ++++ HP +V+L C + Sbjct: 369 IGSGQFGLVHLGYWLNKDKVA-IKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLE 427 Query: 426 RDEGVLVLEFAPNGSLHDHLHASK 497 + LV EF +G L D+L + Sbjct: 428 QAPICLVFEFMEHGCLSDYLRTQR 451
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 44.3 bits (103), Expect = 2e-04 Identities = 32/87 (36%), Positives = 42/87 (48%), Gaps = 9/87 (10%) Frame = +3 Query: 240 AVVGEGSFSTVYLARLAGSSQLAAVK------VHRSSER---LRRAFRQELDALLRVRHP 392 A++G GSF VYL A S +L AVK V S +R L A E+ L + H Sbjct: 398 ALIGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHE 457 Query: 393 HIVRLLAFCDQRDEGVLVLEFAPNGSL 473 HIV+ L D + LE+ P GS+ Sbjct: 458 HIVQYLGSNLNSDHLNIFLEYVPGGSV 484
>KCC4_RAT (P13234) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) (Calspermin) Length = 474 Score = 44.3 bits (103), Expect = 2e-04 Identities = 26/80 (32%), Positives = 43/80 (53%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G+ S VY + G+ + A+KV + + ++ R E+ LLR+ HP+I++L + Sbjct: 48 LGRGATSIVYRCKQKGTQKPYALKVLKKTVD-KKIVRTEIGVLLRLSHPNIIKLKEIFET 106 Query: 426 RDEGVLVLEFAPNGSLHDHL 485 E LVLE G L D + Sbjct: 107 PTEISLVLELVTGGELFDRI 126
>ATG1_NEUCR (Q7RX99) Serine/threonine-protein kinase atg-1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 932 Score = 44.3 bits (103), Expect = 2e-04 Identities = 27/79 (34%), Positives = 42/79 (53%), Gaps = 3/79 (3%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVK---VHRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 +G+GSF+ VYL R + L AVK + R +++L+ E+ L +RHPHIV L Sbjct: 30 IGKGSFAKVYLGRHKVTGALVAVKSVELARLNKKLKENLYGEIQILKTLRHPHIVALHDC 89 Query: 417 CDQRDEGVLVLEFAPNGSL 473 + L++E+ G L Sbjct: 90 VESSTHINLIMEYCELGDL 108
>GSK3_SCHPO (Q10452) Protein kinase gsk3 (EC 2.7.11.1) (Protein kinaae skp1)| Length = 387 Score = 44.3 bits (103), Expect = 2e-04 Identities = 36/109 (33%), Positives = 52/109 (47%), Gaps = 6/109 (5%) Frame = +3 Query: 153 EDQQQPGKVGGARQLSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSS 332 ++ + G G +QLS+ +S VVG GSF V L S AA+K Sbjct: 16 KETARDGSTGEVKQLSYT---------SSKVVGSGSFGVVMQVHLIESDSKAAIKRVLQD 66 Query: 333 ERLRRAFRQELDALLRVRHPHIVRLLAFC----DQRDEGV--LVLEFAP 461 +R + +EL + ++HP+IV L+A+ D DE LVLEF P Sbjct: 67 KRFK---NRELQIMRIMKHPNIVDLIAYYYTTGDNSDEVYLNLVLEFMP 112
>KCC4_MOUSE (P08414) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 469 Score = 44.3 bits (103), Expect = 2e-04 Identities = 26/80 (32%), Positives = 43/80 (53%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G+ S VY + G+ + A+KV + + ++ R E+ LLR+ HP+I++L + Sbjct: 48 LGRGATSIVYRCKQKGTQKPYALKVLKKTVD-KKIVRTEIGVLLRLSHPNIIKLKEIFET 106 Query: 426 RDEGVLVLEFAPNGSLHDHL 485 E LVLE G L D + Sbjct: 107 PTEISLVLELVTGGELFDRI 126
>M4K3_HUMAN (Q8IVH8) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) Length = 894 Score = 43.9 bits (102), Expect = 3e-04 Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAF-RQELDALLRVRHPHIVRLLAFCD 422 +G G++ VY AR + +LAA+KV + A +QE+ + +HP+IV Sbjct: 22 IGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYL 81 Query: 423 QRDEGVLVLEFAPNGSLHDHLHAS 494 +RD+ + +EF GSL D H + Sbjct: 82 RRDKLWICMEFCGGGSLQDIYHVT 105
>RET_HUMAN (P07949) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1114 Score = 43.9 bits (102), Expect = 3e-04 Identities = 29/91 (31%), Positives = 41/91 (45%), Gaps = 7/91 (7%) Frame = +3 Query: 246 VGEGSFSTVYLA---RLAGSSQLAAVKVHRSSERLR----RAFRQELDALLRVRHPHIVR 404 +GEG F V A L G + V V E R E + L +V HPH+++ Sbjct: 730 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIK 789 Query: 405 LLAFCDQRDEGVLVLEFAPNGSLHDHLHASK 497 L C Q +L++E+A GSL L S+ Sbjct: 790 LYGACSQDGPLLLIVEYAKYGSLRGFLRESR 820
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 43.9 bits (102), Expect = 3e-04 Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 8/91 (8%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHR--------SSERLRRAFRQELDALLRVRHPHIV 401 +G G+F+ V LA S + A+K+ S +R F++E+D L + HP +V Sbjct: 173 LGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDILKSLHHPGVV 232 Query: 402 RLLAFCDQRDEGVLVLEFAPNGSLHDHLHAS 494 + + DE +V+E+ G L D L A+ Sbjct: 233 QCHEIFENDDELFIVMEYVEGGDLMDFLIAN 263
>M4K3_MOUSE (Q99JP0) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) (Fragments) Length = 681 Score = 43.9 bits (102), Expect = 3e-04 Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAF-RQELDALLRVRHPHIVRLLAFCD 422 +G G++ VY AR + +LAA+KV + A +QE+ + +HP+IV Sbjct: 22 IGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYL 81 Query: 423 QRDEGVLVLEFAPNGSLHDHLHAS 494 +RD+ + +EF GSL D H + Sbjct: 82 RRDKLWICMEFCGGGSLQDIYHVT 105
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 43.9 bits (102), Expect = 3e-04 Identities = 31/105 (29%), Positives = 55/105 (52%), Gaps = 3/105 (2%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRS---SERLRRAFRQELDALLRVRHPHIVRLLAF 416 +G G + VY + G+ AVK+ S S+ + R+F +E+ + +RHP++V +A Sbjct: 792 LGTGGYGEVYKSIWKGTE--VAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAA 849 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQ 551 + +V+EF GSL+D L + P +P+A + +A Q Sbjct: 850 STKSPNMCIVMEFMSLGSLYDLL---GNELIPEIPYALKIKMAYQ 891
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 43.9 bits (102), Expect = 3e-04 Identities = 32/82 (39%), Positives = 44/82 (53%), Gaps = 5/82 (6%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQELDALLRVRHPHIVRLL 410 ++GEGSFSTV LAR +S+ A+K+ H E +E D + R+ HP V+L Sbjct: 87 ILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLY 146 Query: 411 AFCDQRDEGVLV-LEFAPNGSL 473 F Q DE + L +A NG L Sbjct: 147 -FTFQDDEKLYFGLSYAKNGEL 167
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 43.9 bits (102), Expect = 3e-04 Identities = 32/82 (39%), Positives = 44/82 (53%), Gaps = 5/82 (6%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQELDALLRVRHPHIVRLL 410 ++GEGSFSTV LAR +S+ A+K+ H E +E D + R+ HP V+L Sbjct: 90 ILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLY 149 Query: 411 AFCDQRDEGVLV-LEFAPNGSL 473 F Q DE + L +A NG L Sbjct: 150 -FTFQDDEKLYFGLSYAKNGEL 170
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 43.9 bits (102), Expect = 3e-04 Identities = 32/82 (39%), Positives = 44/82 (53%), Gaps = 5/82 (6%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQELDALLRVRHPHIVRLL 410 ++GEGSFSTV LAR +S+ A+K+ H E +E D + R+ HP V+L Sbjct: 90 ILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLY 149 Query: 411 AFCDQRDEGVLV-LEFAPNGSL 473 F Q DE + L +A NG L Sbjct: 150 -FTFQDDEKLYFGLSYAKNGEL 170
>ATG1_YARLI (Q6C7U0) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 710 Score = 43.9 bits (102), Expect = 3e-04 Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 3/95 (3%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV---HRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 +G GSF+TVY S A+K + + +L E+ L +++HPH+V LL F Sbjct: 13 LGRGSFATVYKGEHVASGSPVAIKSVLRAKLNRKLLENLGSEISILKQMKHPHVVELLDF 72 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLP 521 + LV+E+ G L L K +S LP Sbjct: 73 QETPTHFHLVMEYCSLGDLSFFL-KKKKELSETLP 106
>KPSH1_BRARE (Q501V0) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 422 Score = 43.9 bits (102), Expect = 3e-04 Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 1/83 (1%) Frame = +3 Query: 240 AVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERL-RRAFRQELDALLRVRHPHIVRLLAF 416 A++G GSFS V + Q A+K+ + R R EL L RVRH +I++L+ Sbjct: 100 ALIGRGSFSRVVRVEHRSTRQPYAIKMIETRYREGREVCESELCVLRRVRHTNIIQLMEV 159 Query: 417 CDQRDEGVLVLEFAPNGSLHDHL 485 + + +V+E A G L D + Sbjct: 160 FETAERVYMVMELATGGELFDRI 182
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 43.9 bits (102), Expect = 3e-04 Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 13/113 (11%) Frame = +3 Query: 198 SWAQVEAMTAGFTSAV-------------VGEGSFSTVYLARLAGSSQLAAVKVHRSSER 338 SW Q +TAG +G G F V+L ++A +K + Sbjct: 345 SWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVA-IKTIQEGAM 403 Query: 339 LRRAFRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASK 497 F +E + ++++ HP +V+L C ++ LV EF +G L D+L + + Sbjct: 404 SEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQR 456
>CDKL2_MOUSE (Q9QUK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 568 Score = 43.5 bits (101), Expect = 4e-04 Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 3/82 (3%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSE---RLRRAFRQELDALLRVRHPHIVRLLA 413 +VGEGS+ V R S ++ A+K S+ +++ +E+ L ++RH ++V LL Sbjct: 9 LVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLE 68 Query: 414 FCDQRDEGVLVLEFAPNGSLHD 479 C ++ LV EF + L D Sbjct: 69 VCKKKKRWYLVFEFVDHTILDD 90
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 43.5 bits (101), Expect = 4e-04 Identities = 27/80 (33%), Positives = 38/80 (47%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G+F V+ + S +A VK R AF QE + + RH +V L A C Q Sbjct: 290 LGRGNFGEVFYGKWRNSIDVA-VKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQ 348 Query: 426 RDEGVLVLEFAPNGSLHDHL 485 + +V E+ GSL D L Sbjct: 349 EEPIYIVQEYMSKGSLLDFL 368
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 43.5 bits (101), Expect = 4e-04 Identities = 22/81 (27%), Positives = 42/81 (51%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G GSF TVY + G + + V + + +AF+ E+ L + RH +I+ + + Sbjct: 89 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY-ST 147 Query: 426 RDEGVLVLEFAPNGSLHDHLH 488 + + +V ++ SL+ HLH Sbjct: 148 KPQLAIVTQWCEGSSLYHHLH 168
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 43.5 bits (101), Expect = 4e-04 Identities = 29/86 (33%), Positives = 46/86 (53%), Gaps = 9/86 (10%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKV-----HRSSERLRRAFRQELDA----LLRVRHPH 395 ++G G+F TVY+ S +L AVK + +S+ +A QEL+ L + HP+ Sbjct: 73 LIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPN 132 Query: 396 IVRLLAFCDQRDEGVLVLEFAPNGSL 473 IVR L + + ++LEF P GS+ Sbjct: 133 IVRYLGTVREDETLNILLEFVPGGSI 158
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 43.5 bits (101), Expect = 4e-04 Identities = 22/81 (27%), Positives = 42/81 (51%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G GSF TVY + G + + V + + +AF+ E+ L + RH +I+ + + Sbjct: 503 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY-ST 561 Query: 426 RDEGVLVLEFAPNGSLHDHLH 488 + + +V ++ SL+ HLH Sbjct: 562 KPQLAIVTQWCEGSSLYHHLH 582
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 43.5 bits (101), Expect = 4e-04 Identities = 22/81 (27%), Positives = 42/81 (51%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G GSF TVY + G + + V + + +AF+ E+ L + RH +I+ + + Sbjct: 25 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY-ST 83 Query: 426 RDEGVLVLEFAPNGSLHDHLH 488 + + +V ++ SL+ HLH Sbjct: 84 KPQLAIVTQWCEGSSLYHHLH 104
>CDKL2_RAT (Q5XIT0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 507 Score = 43.5 bits (101), Expect = 4e-04 Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 3/82 (3%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSE---RLRRAFRQELDALLRVRHPHIVRLLA 413 +VGEGS+ V R S ++ A+K S+ +++ +E+ L ++RH ++V LL Sbjct: 9 LVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLE 68 Query: 414 FCDQRDEGVLVLEFAPNGSLHD 479 C ++ LV EF + L D Sbjct: 69 VCKKKKRWYLVFEFVDHTILDD 90
>KPK19_ARATH (Q39030) Serine/threonine-protein kinase AtPK19 (EC 2.7.11.1)| (Ribosomal-protein S6 kinase homolog) Length = 471 Score = 43.5 bits (101), Expect = 4e-04 Identities = 28/86 (32%), Positives = 44/86 (51%), Gaps = 4/86 (4%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRR----AFRQELDALLRVRHPHIVRLL 410 VVG+G+F VY R +S++ A+KV R + + + + E D L ++ HP IV+L Sbjct: 145 VVGQGAFGKVYQVRKKDTSEIYAMKVMRKDKIVEKNHAEYMKAERDILTKIDHPFIVQLK 204 Query: 411 AFCDQRDEGVLVLEFAPNGSLHDHLH 488 + LVL+F G L L+ Sbjct: 205 YSFQTKYRLYLVLDFINGGHLFFQLY 230
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 43.5 bits (101), Expect = 4e-04 Identities = 22/81 (27%), Positives = 42/81 (51%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G GSF TVY + G + + V + + +AF+ E+ L + RH +I+ + + Sbjct: 463 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY-ST 521 Query: 426 RDEGVLVLEFAPNGSLHDHLH 488 + + +V ++ SL+ HLH Sbjct: 522 KPQLAIVTQWCEGSSLYHHLH 542
>TBK1_XENLA (Q6DFJ6) Serine/threonine-protein kinase TBK1 (EC 2.7.11.1)| Length = 725 Score = 43.5 bits (101), Expect = 4e-04 Identities = 33/97 (34%), Positives = 48/97 (49%), Gaps = 4/97 (4%) Frame = +3 Query: 237 SAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQ--ELDALLRVRHPHIVRLL 410 S ++G+G+ + VY R + L AVKV S R A Q E + L ++ H +IV+L Sbjct: 12 SDILGQGATANVYRGRNKKTGDLYAVKVFNSLSFQRPADVQMREFEVLKKLNHKNIVKLF 71 Query: 411 AFCDQRD--EGVLVLEFAPNGSLHDHLHASKASVSPP 515 A ++ VLV+EF P SL+ L S P Sbjct: 72 AIEEEMSSRHKVLVMEFCPCASLYSVLEEPTNSYGLP 108
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 43.5 bits (101), Expect = 4e-04 Identities = 26/91 (28%), Positives = 41/91 (45%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G F V+ A G +A + R + + F+ E+ A+ ++RH HI+ L A Sbjct: 197 LGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATA 256 Query: 426 RDEGVLVLEFAPNGSLHDHLHASKASVSPPL 518 D ++ E P G+L L S P L Sbjct: 257 GDPVYIITELMPKGNLLQLLRDSDEKALPIL 287
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 43.5 bits (101), Expect = 4e-04 Identities = 22/81 (27%), Positives = 42/81 (51%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G GSF TVY + G + + V + + +AF+ E+ L + RH +I+ + + Sbjct: 73 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY-ST 131 Query: 426 RDEGVLVLEFAPNGSLHDHLH 488 + + +V ++ SL+ HLH Sbjct: 132 KPQLAIVTQWCEGSSLYHHLH 152
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 43.5 bits (101), Expect = 4e-04 Identities = 26/108 (24%), Positives = 56/108 (51%), Gaps = 5/108 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLA---AVKV--HRSSERLRRAFRQELDALLRVRHPHIVRLL 410 +GEG+F VY +L ++ A+K +S + ++ F++E++ + ++H +IV +L Sbjct: 416 LGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCIL 475 Query: 411 AFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQV 554 ++ ++ E+ NG LH+ L ++ + L +ALQ+ Sbjct: 476 GVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQIALQI 523
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 43.5 bits (101), Expect = 4e-04 Identities = 22/81 (27%), Positives = 42/81 (51%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G GSF TVY + G + + V + + +AF+ E+ L + RH +I+ + + Sbjct: 503 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY-ST 561 Query: 426 RDEGVLVLEFAPNGSLHDHLH 488 + + +V ++ SL+ HLH Sbjct: 562 KPQLAIVTQWCEGSSLYHHLH 582
>CDKL2_RABIT (Q9TTK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 566 Score = 43.5 bits (101), Expect = 4e-04 Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 3/82 (3%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSE---RLRRAFRQELDALLRVRHPHIVRLLA 413 +VGEGS+ V R S ++ A+K S+ +++ +E+ L ++RH ++V LL Sbjct: 9 LVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLE 68 Query: 414 FCDQRDEGVLVLEFAPNGSLHD 479 C ++ LV EF + L D Sbjct: 69 VCKKKKRWYLVFEFVDHTILDD 90
>RTK2_GEOCY (P42159) Class II receptor tyrosine kinase (EC 2.7.10.1) (GCTK)| Length = 605 Score = 43.5 bits (101), Expect = 4e-04 Identities = 30/100 (30%), Positives = 47/100 (47%), Gaps = 20/100 (20%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSS------------------QLAAVKVHRS--SERLRRAFRQEL 365 +G G F V LA + G S L AVK + SE +R++F +E+ Sbjct: 352 IGVGQFGAVVLAEMTGLSGSERCVPTKRDPSMLNGVALVAVKKLKPDVSEEVRQSFDKEI 411 Query: 366 DALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHL 485 + +++H IV+LLA C +V+E+ NG L+ L Sbjct: 412 KFVSQLQHDSIVQLLAVCTHSKHPFIVMEYMENGDLNQFL 451
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 43.1 bits (100), Expect = 5e-04 Identities = 28/94 (29%), Positives = 50/94 (53%), Gaps = 7/94 (7%) Frame = +3 Query: 246 VGEGSFSTVYLARLA----GSSQLAAVK-VHRSSERLRRAFRQELDALLRVRHPHIVRLL 410 +G+G+F +V + R + ++ AVK + S+E R F +E++ L ++H +IV+ Sbjct: 855 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 914 Query: 411 AFCDQ--RDEGVLVLEFAPNGSLHDHLHASKASV 506 C R L++E+ P GSL D+L K + Sbjct: 915 GVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERI 948 Score = 33.5 bits (75), Expect = 0.42 Identities = 24/96 (25%), Positives = 45/96 (46%), Gaps = 8/96 (8%) Frame = +3 Query: 246 VGEGSFSTVY--LARLAGS-SQLAAVKV-----HRSSERLRRAFRQELDALLRVRHPHIV 401 +G+G+F+ ++ + R G QL +V ++ +F + + ++ H H+V Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLV 610 Query: 402 RLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVS 509 C DE +LV EF GSL +L +K ++ Sbjct: 611 LNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCIN 646
>IKKE_MOUSE (Q9R0T8) Inhibitor of nuclear factor kappa-B kinase epsilon subunit| (EC 2.7.11.1) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK-E) (Inducible I kappa-B kinase) (IKK-i) Length = 717 Score = 43.1 bits (100), Expect = 5e-04 Identities = 29/84 (34%), Positives = 48/84 (57%), Gaps = 4/84 (4%) Frame = +3 Query: 234 TSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQ--ELDALLRVRHPHIVRL 407 T ++G+G+ ++VY AR S ++ AVKV S+ R Q E + L R+ H +IV+L Sbjct: 11 TDDLLGQGATASVYKARNKKSGEVVAVKVFNSASYRRPPEVQVREFEVLRRLNHQNIVKL 70 Query: 408 LAFCDQ--RDEGVLVLEFAPNGSL 473 A + + VL++E+ +GSL Sbjct: 71 FAVEETGGSRQKVLIMEYCSSGSL 94
>NRKB_TRYBB (Q03428) Putative serine/threonine-protein kinase B (EC 2.7.11.1)| Length = 431 Score = 43.1 bits (100), Expect = 5e-04 Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 3/84 (3%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKV---HRSSERLRRAFRQELDALLRVRHPHIVRLLA 413 +VG GS+ Y+A L KV + S R +R + E+ HP+I+R + Sbjct: 25 IVGLGSYGEGYVAERVEDGSLCVAKVMDLSKMSRRDKRYAQSEIKYPTNCNHPNIIRYIE 84 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 ++ D ++V+EFA +G+L + + Sbjct: 85 DHEENDRLLIVMEFADSGNLDEQI 108
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 43.1 bits (100), Expect = 5e-04 Identities = 21/84 (25%), Positives = 46/84 (54%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRA----FRQELDALLRVRHPHIVRLLA 413 +G+G++ V A S ++ A+K R + R+E++ + + HPHI+ + Sbjct: 62 LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYE 121 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 + +D+ V+++E+A G L+D++ Sbjct: 122 VFENKDKIVIIMEYASKGELYDYI 145
>SN1L2_MOUSE (Q8CFH6) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Salt-inducible kinase 2) Length = 931 Score = 43.1 bits (100), Expect = 5e-04 Identities = 25/84 (29%), Positives = 45/84 (53%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSE----RLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G+F+ V L R + A+K+ S+ L + +R E+ + + HPHI++L Sbjct: 26 LGKGNFAVVKLGRHRTTKTEVAIKIIDKSQLDAVNLEKIYR-EVQIMKMLDHPHIIKLYQ 84 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 + + LV E+A NG + D+L Sbjct: 85 VMETKSMLYLVTEYAKNGEIFDYL 108
>LIMK1_DROME (Q8IR79) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (dLIMK)| Length = 1257 Score = 43.1 bits (100), Expect = 5e-04 Identities = 26/104 (25%), Positives = 51/104 (49%), Gaps = 1/104 (0%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVK-VHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCD 422 +GEG F V+ S ++ +K +HR+ E +R F +E+ L + H H+++ + Sbjct: 407 LGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLY 466 Query: 423 QRDEGVLVLEFAPNGSLHDHLHASKASVSPPLPWARRAAVALQV 554 + + +V E+ G L + +H + LPW +R +A + Sbjct: 467 KDKKLHMVTEYVAGGCLKELIH----DPAQVLPWPQRVRLARDI 506
>KPK1_ARATH (P42818) Serine/threonine-protein kinase AtPK1/AtPK6 (EC 2.7.11.1)| Length = 465 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 4/86 (4%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRR----AFRQELDALLRVRHPHIVRLL 410 VVG+G+F VY R +S++ A+KV R + + + E D L ++ HP IV+L Sbjct: 139 VVGKGAFGKVYQVRKKETSEIYAMKVMRKDHIMEKNHAEYMKAERDILTKIDHPFIVQLK 198 Query: 411 AFCDQRDEGVLVLEFAPNGSLHDHLH 488 + LVL+F G L L+ Sbjct: 199 YSFQTKYRLYLVLDFINGGHLFFQLY 224
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 42.7 bits (99), Expect = 7e-04 Identities = 23/89 (25%), Positives = 41/89 (46%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G F V L + G +A VK+ + F QE ++++ HP +V+ C + Sbjct: 423 LGSGQFGVVQLGKWKGQYDVA-VKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSK 481 Query: 426 RDEGVLVLEFAPNGSLHDHLHASKASVSP 512 +V E+ NG L ++L + + P Sbjct: 482 EYPIYIVTEYISNGCLLNYLRSHGKGLEP 510
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/94 (29%), Positives = 50/94 (53%), Gaps = 7/94 (7%) Frame = +3 Query: 246 VGEGSFSTVYLARLA----GSSQLAAVK-VHRSSERLRRAFRQELDALLRVRHPHIVRLL 410 +G+G+F +V + R + ++ AVK + S+E R F +E++ L ++H +IV+ Sbjct: 855 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 914 Query: 411 AFCDQ--RDEGVLVLEFAPNGSLHDHLHASKASV 506 C R L++E+ P GSL D+L K + Sbjct: 915 GVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERI 948 Score = 33.5 bits (75), Expect = 0.42 Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 8/96 (8%) Frame = +3 Query: 246 VGEGSFSTVY--LARLAGS-SQLAAVKV-----HRSSERLRRAFRQELDALLRVRHPHIV 401 +G+G+F+ ++ + R G QL +V ++ +F + + ++ H H+V Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLV 610 Query: 402 RLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVS 509 C +E +LV EF GSL +L +K S++ Sbjct: 611 LNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSIN 646
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/94 (29%), Positives = 50/94 (53%), Gaps = 7/94 (7%) Frame = +3 Query: 246 VGEGSFSTVYLARLA----GSSQLAAVK-VHRSSERLRRAFRQELDALLRVRHPHIVRLL 410 +G+G+F +V + R + ++ AVK + S+E R F +E++ L ++H +IV+ Sbjct: 855 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 914 Query: 411 AFCDQ--RDEGVLVLEFAPNGSLHDHLHASKASV 506 C R L++E+ P GSL D+L K + Sbjct: 915 GVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERI 948 Score = 33.5 bits (75), Expect = 0.42 Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 8/96 (8%) Frame = +3 Query: 246 VGEGSFSTVY--LARLAGS-SQLAAVKV-----HRSSERLRRAFRQELDALLRVRHPHIV 401 +G+G+F+ ++ + R G QL +V ++ +F + + ++ H H+V Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLV 610 Query: 402 RLLAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVS 509 C +E +LV EF GSL +L +K S++ Sbjct: 611 LNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSIN 646
>MARK2_MOUSE (Q05512) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 776 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/86 (32%), Positives = 48/86 (55%), Gaps = 4/86 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G+F+ V LAR + + AVK+ +S L++ FR E+ + + HP+IV+L Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFR-EVRIMKVLNHPNIVKLFE 117 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHLHA 491 + LV+E+A G + D+L A Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVA 143
>ROS_CHICK (P08941) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2311 Score = 42.7 bits (99), Expect = 7e-04 Identities = 30/101 (29%), Positives = 50/101 (49%), Gaps = 9/101 (8%) Frame = +3 Query: 243 VVGEGSFSTVY-------LARLAGSSQLAAVKVHR-SSERLRRAFRQELDALLRVRHPHI 398 ++G G+F VY LA +G S++A + R ++++ + F +E + + HPHI Sbjct: 1966 LLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMSKFDHPHI 2025 Query: 399 VRLLAFCDQRDEGVLVLEFAPNGSLHDHLH-ASKASVSPPL 518 ++LL C + L+LE G L +L A K PL Sbjct: 2026 LKLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPL 2066
>ROS_AVISU (P00529) Tyrosine-protein kinase transforming protein ros (EC| 2.7.10.1) Length = 402 Score = 42.7 bits (99), Expect = 7e-04 Identities = 30/101 (29%), Positives = 50/101 (49%), Gaps = 9/101 (8%) Frame = +3 Query: 243 VVGEGSFSTVY-------LARLAGSSQLAAVKVHR-SSERLRRAFRQELDALLRVRHPHI 398 ++G G+F VY LA +G S++A + R ++++ + F +E + + HPHI Sbjct: 103 LLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMSKFDHPHI 162 Query: 399 VRLLAFCDQRDEGVLVLEFAPNGSLHDHLH-ASKASVSPPL 518 ++LL C + L+LE G L +L A K PL Sbjct: 163 LKLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPL 203
>NEK4_HUMAN (P51957) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Length = 841 Score = 42.7 bits (99), Expect = 7e-04 Identities = 35/111 (31%), Positives = 54/111 (48%), Gaps = 8/111 (7%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVK---VHRSSERLRRAFRQELDALLRVRHPHIVRLLA 413 VVG+GS+ V L + + +K + +S R RRA QE L +++HP+IV Sbjct: 11 VVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKE 70 Query: 414 FCDQRDEGVL--VLEFAPNGSLHDHLHASKASVSPP---LPWARRAAVALQ 551 + D G+L V+ F G L+ L K + P + W + A+ALQ Sbjct: 71 SWEGGD-GLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ 120
>PKD1_DICDI (P34100) Developmentally-regulated protein kinase 1 (EC 2.7.11.1)| (Fragment) Length = 416 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/105 (26%), Positives = 48/105 (45%), Gaps = 4/105 (3%) Frame = +3 Query: 195 LSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSS----ERLRRAFRQE 362 L+W + + F ++ G GSF T L R GS K R E+ + E Sbjct: 26 LTWKRTKISDFNFYGSL-GSGSFGTAKLCRHRGSGLFFCSKTLRRETIVHEKHKEHVNNE 84 Query: 363 LDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLHASK 497 ++ +L + HP+IV+ + + + ++E+A L HL A+K Sbjct: 85 INIMLNISHPYIVKTYSTFNTPTKIHFIMEYAGKKDLFHHLRANK 129
>SGG_DROME (P18431) Protein kinase shaggy (EC 2.7.11.1) (Protein zeste-white| 3) Length = 1067 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/79 (35%), Positives = 44/79 (55%), Gaps = 6/79 (7%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFC- 419 V+G GSF V+ A+L + +L A+K R + +EL + ++ H +IV+LL F Sbjct: 612 VIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFK---NRELQIMRKLEHCNIVKLLYFFY 668 Query: 420 ---DQRDEGV--LVLEFAP 461 ++RDE LVLE+ P Sbjct: 669 SSGEKRDEVFLNLVLEYIP 687
>MARK2_HUMAN (Q7KZI7) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog) Length = 788 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/86 (32%), Positives = 48/86 (55%), Gaps = 4/86 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G+F+ V LAR + + AVK+ +S L++ FR E+ + + HP+IV+L Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFR-EVRIMKVLNHPNIVKLFE 117 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHLHA 491 + LV+E+A G + D+L A Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVA 143
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 42.7 bits (99), Expect = 7e-04 Identities = 27/84 (32%), Positives = 45/84 (53%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +GEG F V+ GS +A VKV +S++ +E++AL +RH ++RL A C Sbjct: 240 LGEGFFGEVWEGLWLGSIPVA-VKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSL 298 Query: 426 RDEGVLVLEFAPNGSLHDHLHASK 497 + +V E G+L +L +S+ Sbjct: 299 GEPVYIVTELMGKGNLQVYLGSSE 322
>PKN3_MOUSE (Q8K045) Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein| kinase PKN-beta) (Protein-kinase C-related kinase 3) Length = 878 Score = 42.7 bits (99), Expect = 7e-04 Identities = 29/93 (31%), Positives = 40/93 (43%), Gaps = 10/93 (10%) Frame = +3 Query: 240 AVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALL----------RVRH 389 AV+G G F V L + G+ + A+K + E L R E+D+L R H Sbjct: 552 AVLGRGHFGKVLLVQYKGTGKYYAIKALKKQEVLGR---DEIDSLYCEKRILETVGRTGH 608 Query: 390 PHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHLH 488 P ++ LLA V EF P G L +H Sbjct: 609 PFLLSLLACLQTSSHACFVTEFLPGGDLMAQIH 641
>MARK2_RAT (O08679) Serine/threonine-protein kinase MARK2 (EC 2.7.11.1)| (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1) Length = 722 Score = 42.7 bits (99), Expect = 7e-04 Identities = 28/86 (32%), Positives = 48/86 (55%), Gaps = 4/86 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV----HRSSERLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G+F+ V LAR + + AVK+ +S L++ FR E+ + + HP+IV+L Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFR-EVRIMKVLNHPNIVKLFE 117 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHLHA 491 + LV+E+A G + D+L A Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVA 143
>MOS_MSVMT (P32593) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 354 Score = 42.7 bits (99), Expect = 7e-04 Identities = 36/123 (29%), Positives = 62/123 (50%), Gaps = 8/123 (6%) Frame = +3 Query: 168 PGKVGGARQLSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLR- 344 P G R+L+W ++ + G G F +VY A G +A +V++ +E LR Sbjct: 55 PRAPGLPRRLAWFSIDWEQVCLMHRL-GSGGFGSVYKATYHGVP-VAIKQVNKCTEDLRA 112 Query: 345 --RAFRQELDALLRVRHPHIVRLLAFCDQRDE-----GVLVLEFAPNGSLHDHLHASKAS 503 R+F EL+ + +RH +IVR++A + E G +++EF N +LH ++ + S Sbjct: 113 SQRSFWAELN-IAGLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYDATRS 171 Query: 504 VSP 512 P Sbjct: 172 PEP 174
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 42.7 bits (99), Expect = 7e-04 Identities = 26/87 (29%), Positives = 42/87 (48%), Gaps = 2/87 (2%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSS--ERLRRAFRQELDALLRVRHPHIVRLLAF 416 ++G+G+F VY L + +A VK + + L+ F QE L + HP+IV+L+ Sbjct: 568 LLGKGNFGEVYKGTLKDKTSVA-VKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGV 626 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASK 497 C QR +++E G L K Sbjct: 627 CTQRQPVYIIMELVSGGDFLTFLRRKK 653
>MERTK_MOUSE (Q60805) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 994 Score = 42.7 bits (99), Expect = 7e-04 Identities = 32/101 (31%), Positives = 48/101 (47%), Gaps = 11/101 (10%) Frame = +3 Query: 243 VVGEGSFSTVYLARLA---GSSQLAAVKVHRS---SERLRRAFRQELDALLRVRHPHIVR 404 V+GEG F +V L G+SQ AVK + S+R F E + HP+++R Sbjct: 587 VLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVIR 646 Query: 405 LLAFC-DQRDEGV----LVLEFAPNGSLHDHLHASKASVSP 512 LL C + +G+ ++L F G LH L S+ + P Sbjct: 647 LLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSRLNTGP 687
>KPK2_PLAFK (Q02595) Probable serine/threonine-protein kinase 2 (EC 2.7.11.1)| Length = 510 Score = 42.7 bits (99), Expect = 7e-04 Identities = 23/82 (28%), Positives = 47/82 (57%), Gaps = 1/82 (1%) Frame = +3 Query: 246 VGEGSFSTVYL-ARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCD 422 +G+GSFST Y+ + +++ +V +S + + E++ L +V H +I++L++ + Sbjct: 117 IGKGSFSTAYIGTNILYGNRVVVKEVDKSKVKESNVY-TEIEVLRKVMHKYIIKLISAYE 175 Query: 423 QRDEGVLVLEFAPNGSLHDHLH 488 Q LVLE+ G L ++L+ Sbjct: 176 QEGFVYLVLEYLKGGELFEYLN 197
>ROR2_DROME (Q9V6K3) Tyrosine-protein kinase transmembrane receptor Ror2| precursor (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase) Length = 724 Score = 42.7 bits (99), Expect = 7e-04 Identities = 29/89 (32%), Positives = 45/89 (50%), Gaps = 7/89 (7%) Frame = +3 Query: 246 VGEGSFSTVYLARLAG-----SSQLAAVKVHR--SSERLRRAFRQELDALLRVRHPHIVR 404 +G+G+F V+ AR G L AVK+ + +S++++ F +E L HP+IVR Sbjct: 447 LGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVR 506 Query: 405 LLAFCDQRDEGVLVLEFAPNGSLHDHLHA 491 LL C L+ E+ G L + L A Sbjct: 507 LLGVCALGRPMCLLFEYMAPGDLSEFLRA 535
>MOS_MSVMO (P00538) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 42.7 bits (99), Expect = 7e-04 Identities = 36/123 (29%), Positives = 62/123 (50%), Gaps = 8/123 (6%) Frame = +3 Query: 168 PGKVGGARQLSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLR- 344 P G R+L+W ++ + G G F +VY A G +A +V++ +E LR Sbjct: 75 PRAPGLPRRLAWFSIDWEQVCLMHRL-GSGGFGSVYKATYHGVP-VAIKQVNKCTEDLRA 132 Query: 345 --RAFRQELDALLRVRHPHIVRLLAFCDQRDE-----GVLVLEFAPNGSLHDHLHASKAS 503 R+F EL+ + +RH +IVR++A + E G +++EF N +LH ++ + S Sbjct: 133 SQRSFWAELN-IAGLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYDATRS 191 Query: 504 VSP 512 P Sbjct: 192 PEP 194
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 42.4 bits (98), Expect = 9e-04 Identities = 25/90 (27%), Positives = 47/90 (52%), Gaps = 5/90 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRA----FRQELDALLRVRHPHIVRLL 410 ++G GSF VY R +++ A+K +R++ ++ F +E+ L ++ HP +V+ + Sbjct: 467 IIGSGSFGKVYKGRC--RNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFV 524 Query: 411 AFC-DQRDEGVLVLEFAPNGSLHDHLHASK 497 C D + +V ++ GSL LH K Sbjct: 525 GACLDDPSQFAIVTQYISGGSLFSLLHEQK 554
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 42.4 bits (98), Expect = 9e-04 Identities = 23/80 (28%), Positives = 38/80 (47%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G G + VY+ S AVK + F +E + ++HP++V+LL C Sbjct: 294 LGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTL 353 Query: 426 RDEGVLVLEFAPNGSLHDHL 485 +V E+ P G+L D+L Sbjct: 354 EPPFYIVTEYMPYGNLLDYL 373
>SN1L2_PONPY (Q5REX1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) Length = 925 Score = 42.4 bits (98), Expect = 9e-04 Identities = 25/84 (29%), Positives = 45/84 (53%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSE----RLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G+F+ V L R + A+K+ S+ L + +R E+ + + HPHI++L Sbjct: 26 LGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYR-EVQIMKMLDHPHIIKLYQ 84 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 + + LV E+A NG + D+L Sbjct: 85 VMETKSMLYLVTEYAKNGEIFDYL 108
>CDPK3_PLAF7 (Q9NJU9) Calcium-dependent protein kinase 3 (EC 2.7.11.1) (PfCDPK3)| Length = 562 Score = 42.4 bits (98), Expect = 9e-04 Identities = 25/82 (30%), Positives = 45/82 (54%), Gaps = 2/82 (2%) Frame = +3 Query: 246 VGEGSFSTVYLA--RLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFC 419 +G+G++ VY A +L S+ V + + + R FRQE+D + + HP++V+LL Sbjct: 124 LGKGTYGCVYKATDKLLKISRAVKVVSKKKLKNIPR-FRQEIDIMKNLDHPNVVKLLETF 182 Query: 420 DQRDEGVLVLEFAPNGSLHDHL 485 + ++ LV+E G L D + Sbjct: 183 EDSNQIYLVMELCTGGELFDKI 204
>GSK3H_DROME (P83101) Putative glycogen synthase kinase-3 homolog (EC 2.7.11.26)| (GSK-3) (Protein gasket) Length = 501 Score = 42.4 bits (98), Expect = 9e-04 Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 6/102 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFC- 419 VVG GSF V+ A++ S+++ A+K R + +EL + ++RH +I+ L F Sbjct: 38 VVGNGSFGVVFQAKMVPSNEMVAIKKVLQDRRFK---NRELQIMRKLRHDNIITLKWFFF 94 Query: 420 ---DQRDEGV--LVLEFAPNGSLHDHLHASKASVSPPLPWAR 530 ++RDE LV+EF P ++A + P+ + R Sbjct: 95 SSGEKRDEVYLNLVMEFLPETLYKVERQYARAKQTLPVNFVR 136
>MERTK_HUMAN (Q12866) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 999 Score = 42.4 bits (98), Expect = 9e-04 Identities = 31/101 (30%), Positives = 47/101 (46%), Gaps = 11/101 (10%) Frame = +3 Query: 243 VVGEGSFSTVYLARLA---GSSQLAAVKVHR---SSERLRRAFRQELDALLRVRHPHIVR 404 ++GEG F +V L G+S AVK + SS R F E + HP+++R Sbjct: 592 ILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSHREIEEFLSEAACMKDFSHPNVIR 651 Query: 405 LLAFC-DQRDEGV----LVLEFAPNGSLHDHLHASKASVSP 512 LL C + +G+ ++L F G LH +L S+ P Sbjct: 652 LLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGP 692
>NEK4_MOUSE (Q9Z1J2) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Length = 792 Score = 42.4 bits (98), Expect = 9e-04 Identities = 35/111 (31%), Positives = 53/111 (47%), Gaps = 8/111 (7%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVK---VHRSSERLRRAFRQELDALLRVRHPHIVRLLA 413 VVG GS+ V L + + +K + +S R RRA QE L +++HP+IV Sbjct: 11 VVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKE 70 Query: 414 FCDQRDEGVL--VLEFAPNGSLHDHLHASKASVSPP---LPWARRAAVALQ 551 + D G+L V+ F G L+ L K + P + W + A+ALQ Sbjct: 71 SWEGGD-GLLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQ 120
>SN1L2_HUMAN (Q9H0K1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 926 Score = 42.4 bits (98), Expect = 9e-04 Identities = 25/84 (29%), Positives = 45/84 (53%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSE----RLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G+F+ V L R + A+K+ S+ L + +R E+ + + HPHI++L Sbjct: 26 LGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYR-EVQIMKMLDHPHIIKLYQ 84 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 + + LV E+A NG + D+L Sbjct: 85 VMETKSMLYLVTEYAKNGEIFDYL 108
>CDKL2_MACFA (Q4R7T5) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 570 Score = 42.4 bits (98), Expect = 9e-04 Identities = 24/82 (29%), Positives = 43/82 (52%), Gaps = 3/82 (3%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSE---RLRRAFRQELDALLRVRHPHIVRLLA 413 +VGEGS+ V R + ++ A+K S+ +++ +E+ L ++RH ++V LL Sbjct: 9 LVGEGSYGMVVKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLE 68 Query: 414 FCDQRDEGVLVLEFAPNGSLHD 479 C ++ LV EF + L D Sbjct: 69 VCKKKKRWYLVFEFVDHTILDD 90
>ATG1_EMENI (Q5BCU8) Serine/threonine-protein kinase atg1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 935 Score = 42.4 bits (98), Expect = 9e-04 Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 3/79 (3%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVK---VHRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 +G+GSF+TVY S A+K + + + +L+ E+D L + HPHIV LL Sbjct: 30 IGKGSFATVYRGVQTKSRTFVAIKSVNLGKLNRKLKDNLAMEIDILKYLLHPHIVALLDC 89 Query: 417 CDQRDEGVLVLEFAPNGSL 473 + L++E+ G L Sbjct: 90 LETNSHIHLIMEYCALGDL 108
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 42.4 bits (98), Expect = 9e-04 Identities = 25/90 (27%), Positives = 47/90 (52%), Gaps = 5/90 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRA----FRQELDALLRVRHPHIVRLL 410 ++G GSF VY R +++ A+K +R++ ++ F +E+ L ++ HP +V+ + Sbjct: 466 IIGSGSFGKVYKGRC--RNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFV 523 Query: 411 AFC-DQRDEGVLVLEFAPNGSLHDHLHASK 497 C D + +V ++ GSL LH K Sbjct: 524 GACLDDPSQFAIVTQYISGGSLFSLLHEQK 553
>CDKL2_PONPY (Q5R754) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 493 Score = 42.4 bits (98), Expect = 9e-04 Identities = 24/82 (29%), Positives = 43/82 (52%), Gaps = 3/82 (3%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSE---RLRRAFRQELDALLRVRHPHIVRLLA 413 +VGEGS+ V R + ++ A+K S+ +++ +E+ L ++RH ++V LL Sbjct: 9 LVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLE 68 Query: 414 FCDQRDEGVLVLEFAPNGSLHD 479 C ++ LV EF + L D Sbjct: 69 VCKKKKRWYLVFEFVDHTILDD 90
>CDKL2_HUMAN (Q92772) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE) Length = 493 Score = 42.4 bits (98), Expect = 9e-04 Identities = 24/82 (29%), Positives = 43/82 (52%), Gaps = 3/82 (3%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSE---RLRRAFRQELDALLRVRHPHIVRLLA 413 +VGEGS+ V R + ++ A+K S+ +++ +E+ L ++RH ++V LL Sbjct: 9 LVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLE 68 Query: 414 FCDQRDEGVLVLEFAPNGSLHD 479 C ++ LV EF + L D Sbjct: 69 VCKKKKRWYLVFEFVDHTILDD 90
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 42.4 bits (98), Expect = 9e-04 Identities = 29/106 (27%), Positives = 55/106 (51%), Gaps = 12/106 (11%) Frame = +3 Query: 240 AVVGEGSFSTVYLARLAGSSQLAAVKVHR---SSERLRRAFRQELDALLRVRHPHIVRLL 410 A +GEG+F V +A + ++ + AVK+ + + + + R+ + RH +I+ LL Sbjct: 420 ATLGEGAFGRVVMAEV--NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLL 477 Query: 411 AFCDQRDEGVLVLEFAPNGSLHDHLHASK---------ASVSPPLP 521 C Q +++E+AP+G+L D L+ ++ +S PP P Sbjct: 478 GCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSP 523
>KG1Z_YEAST (P53233) Probable serine/threonine-protein kinase YGR052W (EC| 2.7.11.1) Length = 369 Score = 42.4 bits (98), Expect = 9e-04 Identities = 27/96 (28%), Positives = 45/96 (46%), Gaps = 4/96 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVR----HPHIVRLLA 413 + G+FSTVY A ++ A+K+ + + E D + + HP+I +L Sbjct: 8 IQSGTFSTVYKAWSTTHNRYVALKITPKYKTSEANMKNEYDVMKILSSCNPHPNICSMLD 67 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHLHASKASVSPPLP 521 F ++VLE+ G L+D L +K+ SP P Sbjct: 68 FYTDDSYYIMVLEYCECGDLYDFLDIAKSQGSPSSP 103
>CDK7_RAT (P51952) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 protein kinase) (P39 Mo15) (Fragment) Length = 329 Score = 42.0 bits (97), Expect = 0.001 Identities = 26/76 (34%), Positives = 41/76 (53%), Gaps = 6/76 (7%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV----HRSSER--LRRAFRQELDALLRVRHPHIVRL 407 +GEG F+TVY AR ++Q+ A+K HRS + + R +E+ L + HP+I+ L Sbjct: 10 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 69 Query: 408 LAFCDQRDEGVLVLEF 455 L + LV +F Sbjct: 70 LDAFGHKSNISLVFDF 85
>TBK1_MOUSE (Q9WUN2) Serine/threonine-protein kinase TBK1 (EC 2.7.11.1)| (TANK-binding kinase 1) (T2K) Length = 729 Score = 42.0 bits (97), Expect = 0.001 Identities = 28/84 (33%), Positives = 46/84 (54%), Gaps = 4/84 (4%) Frame = +3 Query: 237 SAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQ--ELDALLRVRHPHIVRLL 410 S ++G+G+ + V+ R + L AVKV + LR Q E + L ++ H +IV+L Sbjct: 12 SDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 Query: 411 AFCDQRD--EGVLVLEFAPNGSLH 476 A ++ VL++EF P GSL+ Sbjct: 72 AIEEETTTRHKVLIMEFCPCGSLY 95
>DDR1_RAT (Q63474) Epithelial discoidin domain-containing receptor 1| precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein- Length = 910 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/117 (27%), Positives = 54/117 (46%), Gaps = 20/117 (17%) Frame = +3 Query: 246 VGEGSFSTVYLARLA----------------GSSQLAAVKVHR--SSERLRRAFRQELDA 371 +GEG F V+L + G L AVK+ R +++ R F +E+ Sbjct: 613 LGEGQFGEVHLCEVEDPQDLVTSDFPISVQKGHPLLVAVKILRPDATKNARNDFLKEVKI 672 Query: 372 LLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHL--HASKASVSPPLPWARRA 536 + R++ +I+RLL C Q D ++ ++ NG L+ L H + V+ LP R + Sbjct: 673 MSRLKDLNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLENKVTQGLPGDRES 729
>CIPK1_ORYSA (Q6X4A2) CIPK-like protein 1 (EC 2.7.11.1) (OsCK1)| Length = 449 Score = 42.0 bits (97), Expect = 0.001 Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 8/86 (9%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV--------HRSSERLRRAFRQELDALLRVRHPHIV 401 +GEG+F+ V A+ + + A+K+ HR E++RR E+ + V+HP++V Sbjct: 26 IGEGTFAKVRFAKNTENDEPVAIKILDKEKVQKHRLVEQIRR----EICTMKLVKHPNVV 81 Query: 402 RLLAFCDQRDEGVLVLEFAPNGSLHD 479 RL + +VLE+ G L + Sbjct: 82 RLFEVMGSKARIFIVLEYVTGGELFE 107
>IPL1_CANGA (Q6FV07) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 358 Score = 42.0 bits (97), Expect = 0.001 Identities = 25/84 (29%), Positives = 43/84 (51%), Gaps = 4/84 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLR----RAFRQELDALLRVRHPHIVRLLA 413 +G+G F VY R S + A+K +E L+ + ++E+D L + HP+I++L A Sbjct: 106 LGKGKFGKVYCVRHKKSGFICALKAIEKNEILQFNLLKQLKREVDIQLGMDHPNIIKLYA 165 Query: 414 FCDQRDEGVLVLEFAPNGSLHDHL 485 L++E + NG L+ L Sbjct: 166 HFHDEKRVYLLMEHSINGELYKSL 189
>ATG1_BOTCI (Q6H9I1) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) (Botryotinia fuckeliana putative kinase exons 1-3) Length = 952 Score = 42.0 bits (97), Expect = 0.001 Identities = 25/79 (31%), Positives = 42/79 (53%), Gaps = 3/79 (3%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVK---VHRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 +G+GSF+TVY S L A+K + R +++L+ E++ L + HPHIV L+ Sbjct: 29 IGKGSFATVYRGTHMPSGNLVAIKSVNLSRLNKKLKDNLYVEIEILKSLYHPHIVALIDC 88 Query: 417 CDQRDEGVLVLEFAPNGSL 473 + L++E+ G L Sbjct: 89 RESASHIHLMMEYCELGDL 107
>STK36_MOUSE (Q69ZM6) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1268 Score = 42.0 bits (97), Expect = 0.001 Identities = 26/76 (34%), Positives = 45/76 (59%), Gaps = 4/76 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAV----KVHRSSERLRRAFRQELDALLRVRHPHIVRLL 410 ++GEGSF VY R S+Q+ A+ K+ RS + LR ++E++ + + HP+IV +L Sbjct: 9 MIGEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKELRN-LQREIEIMRGLWHPNIVHML 67 Query: 411 AFCDQRDEGVLVLEFA 458 + E V+V ++A Sbjct: 68 DSFETDKEVVVVTDYA 83
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 42.0 bits (97), Expect = 0.001 Identities = 24/79 (30%), Positives = 40/79 (50%), Gaps = 3/79 (3%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRR---AFRQELDALLRVRHPHIVRLLAF 416 +G+G+F VY + + AVK + S+ L+ + E+D L + HP+IV+ Sbjct: 15 LGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVKYRGS 74 Query: 417 CDQRDEGVLVLEFAPNGSL 473 D ++LE+ NGSL Sbjct: 75 YQTNDSLCIILEYCENGSL 93
>ROR2_MOUSE (Q9Z138) Tyrosine-protein kinase transmembrane receptor ROR2| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2) Length = 944 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/118 (27%), Positives = 51/118 (43%), Gaps = 7/118 (5%) Frame = +3 Query: 153 EDQQQPGKVGGARQLSWAQVEAMTAGFTSAVVGEGSFSTVYLARLAGSS-----QLAAVK 317 +D + P + +Q ++ T F + GE F VY L G + Q A+K Sbjct: 450 QDMEMP-LISQHKQAKLKEISLSTVRFMEEL-GEDRFGKVYKGHLFGPAPGEPTQAVAIK 507 Query: 318 VHRSSER--LRRAFRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHL 485 + LR FRQE R++HP+IV LL + ++ + +G LH+ L Sbjct: 508 TLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFL 565
>DDR2_HUMAN (Q16832) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 855 Score = 42.0 bits (97), Expect = 0.001 Identities = 27/98 (27%), Positives = 47/98 (47%), Gaps = 18/98 (18%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQ----------------LAAVKVHRS--SERLRRAFRQELDA 371 +GEG F V+L + G + L AVK+ R+ ++ R F +E+ Sbjct: 569 LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKI 628 Query: 372 LLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHL 485 + R++ P+I+ LL+ C D ++ E+ NG L+ L Sbjct: 629 MSRLKDPNIIHLLSVCITDDPLCMITEYMENGDLNQFL 666
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 42.0 bits (97), Expect = 0.001 Identities = 25/83 (30%), Positives = 45/83 (54%), Gaps = 3/83 (3%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV---HRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 +G G F+ V LA + ++ A+K+ + L R + E++AL +RH HI +L Sbjct: 17 IGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPR-IKTEIEALKNLRHQHICQLYHV 75 Query: 417 CDQRDEGVLVLEFAPNGSLHDHL 485 + ++ +VLE+ P G L D++ Sbjct: 76 LETANKIFMVLEYCPGGELFDYI 98
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 42.0 bits (97), Expect = 0.001 Identities = 26/86 (30%), Positives = 43/86 (50%), Gaps = 9/86 (10%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKV------HRSSERLR---RAFRQELDALLRVRHPH 395 ++G G+F VY+ S +L A+K S E+ + R +E+ L + HP+ Sbjct: 73 LIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPN 132 Query: 396 IVRLLAFCDQRDEGVLVLEFAPNGSL 473 IVR L + D +++EF P GS+ Sbjct: 133 IVRYLGTVRESDSLNILMEFVPGGSI 158
>KCC1A_RAT (Q63450) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 42.0 bits (97), Expect = 0.001 Identities = 31/109 (28%), Positives = 51/109 (46%), Gaps = 3/109 (2%) Frame = +3 Query: 168 PGKVGGARQLSWAQVEAMTAGFTSA-VVGEGSFSTVYLARLAGSSQLAAVK--VHRSSER 338 PG V G R W Q E + + V+G G+FS V LA + +L A+K ++ E Sbjct: 2 PGAVEGPR---WKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKKALEG 58 Query: 339 LRRAFRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHL 485 + E+ L +++HP+IV L + L+++ G L D + Sbjct: 59 KEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRI 107
>KCC1A_MOUSE (Q91YS8) Calcium/calmodulin-dependent protein kinase type 1 (EC| 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 374 Score = 42.0 bits (97), Expect = 0.001 Identities = 31/109 (28%), Positives = 51/109 (46%), Gaps = 3/109 (2%) Frame = +3 Query: 168 PGKVGGARQLSWAQVEAMTAGFTSA-VVGEGSFSTVYLARLAGSSQLAAVK--VHRSSER 338 PG V G R W Q E + + V+G G+FS V LA + +L A+K ++ E Sbjct: 2 PGAVEGPR---WKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKKALEG 58 Query: 339 LRRAFRQELDALLRVRHPHIVRLLAFCDQRDEGVLVLEFAPNGSLHDHL 485 + E+ L +++HP+IV L + L+++ G L D + Sbjct: 59 KEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRI 107
>CDK7_MOUSE (Q03147) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinas Length = 346 Score = 42.0 bits (97), Expect = 0.001 Identities = 26/76 (34%), Positives = 41/76 (53%), Gaps = 6/76 (7%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV----HRSSER--LRRAFRQELDALLRVRHPHIVRL 407 +GEG F+TVY AR ++Q+ A+K HRS + + R +E+ L + HP+I+ L Sbjct: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 Query: 408 LAFCDQRDEGVLVLEF 455 L + LV +F Sbjct: 78 LDAFGHKSNISLVFDF 93
>CDK7_HUMAN (P50613) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) Length = 346 Score = 42.0 bits (97), Expect = 0.001 Identities = 26/76 (34%), Positives = 41/76 (53%), Gaps = 6/76 (7%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKV----HRSSER--LRRAFRQELDALLRVRHPHIVRL 407 +GEG F+TVY AR ++Q+ A+K HRS + + R +E+ L + HP+I+ L Sbjct: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 Query: 408 LAFCDQRDEGVLVLEF 455 L + LV +F Sbjct: 78 LDAFGHKSNISLVFDF 93
>ATG1_CANAL (Q5A649) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 834 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/80 (33%), Positives = 44/80 (55%), Gaps = 4/80 (5%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVK-VHRS---SERLRRAFRQELDALLRVRHPHIVRLLA 413 +G+GSF+TVY +++ A+K V+RS S++L E+ L ++HPHIV LL Sbjct: 64 IGKGSFATVYKCIDTTNNKAVAIKSVYRSKLKSKKLLENLEIEIQILKSMKHPHIVGLLD 123 Query: 414 FCDQRDEGVLVLEFAPNGSL 473 + LV+++ G L Sbjct: 124 YKQTTSYFHLVMDYCSMGDL 143
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/86 (32%), Positives = 44/86 (51%), Gaps = 5/86 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLA--GSSQL-AAVKVHRS--SERLRRAFRQELDALLRVRHPHIVRL 407 V+G G F VY RL G ++ A+K ++ SE+ RR F E + + HP+I+RL Sbjct: 624 VIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRL 683 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHL 485 + +++ EF NG+L L Sbjct: 684 EGVVTKSRPVMIITEFMENGALDSFL 709
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/86 (32%), Positives = 44/86 (51%), Gaps = 5/86 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLA--GSSQL-AAVKVHRS--SERLRRAFRQELDALLRVRHPHIVRL 407 V+G G F VY RL G ++ A+K ++ SE+ RR F E + + HP+I+RL Sbjct: 624 VIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRL 683 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHL 485 + +++ EF NG+L L Sbjct: 684 EGVVTKSRPVMIITEFMENGALDSFL 709
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/86 (32%), Positives = 44/86 (51%), Gaps = 5/86 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLA--GSSQL-AAVKVHRS--SERLRRAFRQELDALLRVRHPHIVRL 407 V+G G F VY RL G ++ A+K ++ SE+ RR F E + + HP+I+RL Sbjct: 624 VIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRL 683 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHL 485 + +++ EF NG+L L Sbjct: 684 EGVVTKSRPVMIITEFMENGALDSFL 709
>CDKL1_HUMAN (Q00532) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIALRE) (Protein kinase p42 KKIALRE) Length = 357 Score = 41.6 bits (96), Expect = 0.002 Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 3/81 (3%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSER---LRRAFRQELDALLRVRHPHIVRLLAF 416 +GEGS+ V+ R + Q+ A+K SE +++ +E+ L +++HP++V LL Sbjct: 10 IGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEV 69 Query: 417 CDQRDEGVLVLEFAPNGSLHD 479 ++ LV E+ + LH+ Sbjct: 70 FRRKRRLHLVFEYCDHTVLHE 90
>ATG1_MAGGR (Q52EB3) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 982 Score = 41.6 bits (96), Expect = 0.002 Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 3/81 (3%) Frame = +3 Query: 240 AVVGEGSFSTVYLARLAGSSQLAAVK---VHRSSERLRRAFRQELDALLRVRHPHIVRLL 410 A +G+GSF+ VY+ + S A+K + R +++L+ E++ L +RHPHIV L Sbjct: 23 AEIGKGSFAQVYMGKHKVSGAAVAIKSVELARLNKKLKENLYGEINILKTLRHPHIVALH 82 Query: 411 AFCDQRDEGVLVLEFAPNGSL 473 + L++E+ G L Sbjct: 83 DCVESATHINLMMEYCELGDL 103
>ZYG1_CAEBR (Q621J7) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 709 Score = 41.6 bits (96), Expect = 0.002 Identities = 22/80 (27%), Positives = 42/80 (52%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQELDALLRVRHPHIVRLLAFCDQ 425 +G+G F VY A+ ++A K+ ++ + R ++E+ + +RH +IV+ + Sbjct: 19 IGQGGFGVVYSAQRENGEKVAIKKIGNAASQTR--IKEEIKTMKLLRHRNIVQFYETFFE 76 Query: 426 RDEGVLVLEFAPNGSLHDHL 485 E LV+E GSL D++ Sbjct: 77 NGETYLVMELCEGGSLMDYV 96
>PKN1_MOUSE (P70268) Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein| kinase C-like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) Length = 946 Score = 41.6 bits (96), Expect = 0.002 Identities = 29/92 (31%), Positives = 45/92 (48%), Gaps = 8/92 (8%) Frame = +3 Query: 240 AVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRR-------AFRQELDALLRVRHPHI 398 AV+G G F V L+ S +L A+K + + + R ++ L A+ R HP + Sbjct: 623 AVLGRGHFGKVLLSEFRSSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTRAGHPFL 682 Query: 399 VRLLAFCDQRDEGV-LVLEFAPNGSLHDHLHA 491 V L C Q E V V+E++ G L H+H+ Sbjct: 683 VNLFG-CFQTPEHVCFVMEYSAGGDLMLHIHS 713
>KPK7_ARATH (Q05999) Putative serine/threonine-protein kinase PK7 (EC 2.7.11.1)| Length = 578 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/82 (34%), Positives = 40/82 (48%), Gaps = 5/82 (6%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSS-----ERLRRAFRQELDALLRVRHPHIVRLL 410 +G G VYLA L G+ AVKV + ++L RA + E + L + HP + L Sbjct: 188 LGGGDIGNVYLAELIGTGVSFAVKVMEKAAIAARKKLVRA-QTEKEILQSLDHPFLPTLY 246 Query: 411 AFCDQRDEGVLVLEFAPNGSLH 476 + + LV+EF P G LH Sbjct: 247 SHFETEMNSCLVMEFCPGGDLH 268
>SGK1_RABIT (Q9XT18) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 41.6 bits (96), Expect = 0.002 Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 5/95 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRA----FRQELDALLR-VRHPHIVRL 407 V+G+GSF V LAR AVKV + L++ E + LL+ V+HP +V L Sbjct: 103 VIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGL 162 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSP 512 D+ VL++ G L HL + + P Sbjct: 163 HFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 197
>M3K1_HUMAN (Q13233) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (Fragment) Length = 1495 Score = 41.6 bits (96), Expect = 0.002 Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 7/83 (8%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVK-------VHRSSERLRRAFRQELDALLRVRHPHIVR 404 +G G+FS+ Y A+ G+ L AVK E + A R+E+ + + HP+I+R Sbjct: 1232 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIR 1291 Query: 405 LLAFCDQRDEGVLVLEFAPNGSL 473 +L ++ L +E+ GS+ Sbjct: 1292 MLGATCEKSNYNLFIEWMAGGSV 1314
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 2/91 (2%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVK--VHRSSERLRRAFRQELDALLRVRHPHIVRLLAF 416 V+G GS+ VY A + Q+ A+K V+ + E L E+ L + H +IV+ F Sbjct: 30 VIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMA-EISLLKNLNHNNIVKYHGF 88 Query: 417 CDQRDEGVLVLEFAPNGSLHDHLHASKASVS 509 + E ++LE+ NGSL + S +S Sbjct: 89 IRKSYELYILLEYCANGSLRRLISRSSTGLS 119
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 41.6 bits (96), Expect = 0.002 Identities = 20/81 (24%), Positives = 40/81 (49%), Gaps = 4/81 (4%) Frame = +3 Query: 246 VGEGSFSTVYLARLAGSSQLAAVKVHRSSE----RLRRAFRQELDALLRVRHPHIVRLLA 413 +G+G F VY R + + A+KV E L++ FR+E++ + HP++ + Sbjct: 110 LGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLNHPNLTKSYG 169 Query: 414 FCDQRDEGVLVLEFAPNGSLH 476 + L++E+ NG ++ Sbjct: 170 YFHDEKRVYLLMEYLVNGEMY 190
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 5/86 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQL---AAVKVHRS--SERLRRAFRQELDALLRVRHPHIVRL 407 V+G G F VY RL S+ A+K ++ SE+ RR F E + + HP+I+RL Sbjct: 542 VIGAGEFGEVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRL 601 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHL 485 + +++ EF NG+L L Sbjct: 602 EGVVTKSRPVMIITEFMENGALDSFL 627
>PKN3_HUMAN (Q6P5Z2) Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein| kinase PKN-beta) (Protein-kinase C-related kinase 3) Length = 889 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/90 (30%), Positives = 40/90 (44%), Gaps = 7/90 (7%) Frame = +3 Query: 240 AVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRR-------AFRQELDALLRVRHPHI 398 AV+G G F V L + G+ + A+K + E L R ++ L+A+ HP + Sbjct: 563 AVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFL 622 Query: 399 VRLLAFCDQRDEGVLVLEFAPNGSLHDHLH 488 + LLA V EF P G L +H Sbjct: 623 LSLLACFQTSSHACFVTEFVPGGDLMMQIH 652
>TBK1_HUMAN (Q9UHD2) Serine/threonine-protein kinase TBK1 (EC 2.7.11.1)| (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase) Length = 729 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/84 (32%), Positives = 46/84 (54%), Gaps = 4/84 (4%) Frame = +3 Query: 237 SAVVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRAFRQ--ELDALLRVRHPHIVRLL 410 S ++G+G+ + V+ R + L A+KV + LR Q E + L ++ H +IV+L Sbjct: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71 Query: 411 AFCDQRD--EGVLVLEFAPNGSLH 476 A ++ VL++EF P GSL+ Sbjct: 72 AIEEETTTRHKVLIMEFCPCGSLY 95
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 5/86 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQL---AAVKVHRS--SERLRRAFRQELDALLRVRHPHIVRL 407 V+G G F VY RL S+ A+K ++ SE+ RR F E + + HP+I+RL Sbjct: 625 VIGAGEFGEVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRL 684 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHL 485 + +++ EF NG+L L Sbjct: 685 EGVVTKSRPVMIITEFMENGALDSFL 710
>SGK1_RAT (Q06226) Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 1) Length = 430 Score = 41.6 bits (96), Expect = 0.002 Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 5/95 (5%) Frame = +3 Query: 243 VVGEGSFSTVYLARLAGSSQLAAVKVHRSSERLRRA----FRQELDALLR-VRHPHIVRL 407 V+G+GSF V LAR AVKV + L++ E + LL+ V+HP +V L Sbjct: 103 VIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGL 162 Query: 408 LAFCDQRDEGVLVLEFAPNGSLHDHLHASKASVSP 512 D+ VL++ G L HL + + P Sbjct: 163 HFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 197 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 34,902,921 Number of Sequences: 219361 Number of extensions: 517906 Number of successful extensions: 3610 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 3257 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 3369 length of database: 80,573,946 effective HSP length: 105 effective length of database: 57,541,041 effective search space used: 4545742239 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
