ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bart11e12 |
|---|---|
| Clone Library Name | barley_pub |
>CDPK_DAUCA (P28582) Calcium-dependent protein kinase (EC 2.7.11.1) (CDPK)| Length = 532 Score = 90.5 bits (223), Expect = 3e-18 Identities = 58/180 (32%), Positives = 92/180 (51%), Gaps = 4/180 (2%) Frame = +2 Query: 8 KPEENH*TMSGELNRD----YXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDD 175 +PE N T+ G+ D Y FG V++CT S+G+ +A KS+ + L Sbjct: 63 RPESN--TILGKPFEDIRGKYTLGKELGRGQFGCVYQCTENSSGQLYACKSILKRKLVSK 120 Query: 176 LDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPV 355 D+E + E ++ Q +G P +V+ V+ED H+VM+LC+G +L D R+ Sbjct: 121 NDKEDIKREIQILQ-HLSGQPNIVEFKGVFEDRQSVHLVMELCAGGELFD--RIIAQGHY 177 Query: 356 PEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWI 535 E AA I Q+ + +CH GV+HRD+KP+N +L D+ + DFG + +I Sbjct: 178 SERAAATICRQIVNVVHVCHFMGVMHRDLKPENFLLSSKDK----DAMLKATDFGLSVFI 233
>CDPK2_MAIZE (P49101) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (CDPK 2)| Length = 513 Score = 88.2 bits (217), Expect = 1e-17 Identities = 51/149 (34%), Positives = 79/149 (53%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FGV + CT ++G +A KS+ + L DRE E ++ Q +G P +V+ YE Sbjct: 76 FGVTYLCTEIASGRQYACKSISKRKLVSKADREDIRREIQIMQ-HLSGQPNIVEFRGAYE 134 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D S H+VM+LC+G +L D R+ E AA I + + +CH GV+HRD+KP Sbjct: 135 DKSNVHVVMELCAGGELFD--RIIAKGHYTERAAATICRAVVNVVNICHFMGVMHRDLKP 192 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWI 535 +N +L +E + + DFG + +I Sbjct: 193 ENFLLATMEE----NAMLKATDFGLSVFI 217
>CDPK2_ORYSA (P53683) Calcium-dependent protein kinase, isoform 2 (EC 2.7.11.1)| (CDPK 2) Length = 533 Score = 85.1 bits (209), Expect = 1e-16 Identities = 49/149 (32%), Positives = 79/149 (53%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FGV + CT ++G+ +A KS+ + L D+E E ++ Q +G +V+ YE Sbjct: 96 FGVTYLCTEIASGKQYACKSISKRKLVSKADKEDIRREIQIMQ-HLSGQQNIVEFRGAYE 154 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D S H+VM+LC+G +L D R+ E AA I + + +CH GV+HRD+KP Sbjct: 155 DKSNVHVVMELCAGGELFD--RIIAKGHYSERAAATICRAVVNVVNICHFMGVMHRDLKP 212 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWI 535 +N +L +E + + DFG + +I Sbjct: 213 ENFLLATKEE----NAMLKATDFGLSVFI 237
>CDPK3_ORYSA (P53684) Calcium-dependent protein kinase, isoform 11 (EC 2.7.11.1)| (CDPK 11) Length = 542 Score = 82.4 bits (202), Expect = 8e-16 Identities = 48/149 (32%), Positives = 79/149 (53%), Gaps = 1/149 (0%) Frame = +2 Query: 35 SGELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLA 214 + +L Y FG + CT +TG +A K++ + L D E E ++ Sbjct: 72 TADLREHYIIGRKLGQGQFGTTYLCTEINTGCEYACKTIPKRKLITKEDVEDVRREIQIM 131 Query: 215 QLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLA 394 +G+ VV + VYED H+VM+LC+G +L D R++ E AA+++ + Sbjct: 132 H-HLSGHKNVVAIKDVYEDGQAVHIVMELCAGGELFD--RIQEKGHYSERKAAELIRIIV 188 Query: 395 QALALCHRRGVIHRDVKPDN-VVLDVDDE 478 +A+CH GV+HRD+KP+N ++LD DD+ Sbjct: 189 SIVAMCHSLGVMHRDLKPENFLLLDKDDD 217
>CDPK_SOYBN (P28583) Calcium-dependent protein kinase SK5 (EC 2.7.11.1) (CDPK)| Length = 508 Score = 80.9 bits (198), Expect = 2e-15 Identities = 50/149 (33%), Positives = 79/149 (53%), Gaps = 5/149 (3%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLP-----DDLDRELAEIEPKLAQLAAAGNPGVVQV 253 FG CT R++G FA KS+ + L +D+ RE+ +I L++ A VV++ Sbjct: 45 FGTTFECTRRASGGKFACKSIPKRKLLCKEDYEDVWREI-QIMHHLSEHA-----NVVRI 98 Query: 254 HAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIH 433 YED + H+VM+LC G +L D R+ + E AA ++ + + + CH GV+H Sbjct: 99 EGTYEDSTAVHLVMELCEGGELFD--RIVQKGHYSERQAARLIKTIVEVVEACHSLGVMH 156 Query: 434 RDVKPDNVVLDVDDEGENGSPRARLADFG 520 RD+KP+N + D DE + + DFG Sbjct: 157 RDLKPENFLFDTIDE----DAKLKATDFG 181
>RAD53_YEAST (P22216) Serine/threonine-protein kinase RAD53 (EC 2.7.11.1)| (Serine-protein kinase 1) Length = 821 Score = 80.1 bits (196), Expect = 4e-15 Identities = 47/146 (32%), Positives = 75/146 (51%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V + R+TG+ FAVK + + + ++D E+E L +P +V++ YE Sbjct: 209 FATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEV----LQKLNHPRIVRLKGFYE 264 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D +MVM+ SG DL+D+V V E +I Q+ A+ H G+ HRD+KP Sbjct: 265 DTESYYMVMEFVSGGDLMDFVAAH--GAVGEDAGREISRQILTAIKYIHSMGISHRDLKP 322 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 DN++++ DD ++ DFG A Sbjct: 323 DNILIEQDD-----PVLVKITDFGLA 343
>CSKP_MOUSE (O70589) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (Calcium/calmodulin-dependent serine protein kinase) Length = 924 Score = 79.7 bits (195), Expect = 5e-15 Identities = 53/160 (33%), Positives = 77/160 (48%), Gaps = 2/160 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC +R TG+ FAVK VD + +++ + + +P +V++ Y Sbjct: 23 FSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYS 82 Query: 269 DDSWTHMVMDLCSGPDLLDWV--RLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDV 442 D +MV + G DL + R G E VA+ + Q+ +AL CH +IHRDV Sbjct: 83 SDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDV 142 Query: 443 KPDNVVLDVDDEGENGSPRARLADFGSAAWIGADGGRAEG 562 KP V+L EN +P +L FG A +G G A G Sbjct: 143 KPHCVLL---ASKENSAP-VKLGGFGVAIQLGESGLVAGG 178
>CSKP_HUMAN (O14936) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog) Length = 926 Score = 79.7 bits (195), Expect = 5e-15 Identities = 53/160 (33%), Positives = 77/160 (48%), Gaps = 2/160 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC +R TG+ FAVK VD + +++ + + +P +V++ Y Sbjct: 23 FSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYS 82 Query: 269 DDSWTHMVMDLCSGPDLLDWV--RLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDV 442 D +MV + G DL + R G E VA+ + Q+ +AL CH +IHRDV Sbjct: 83 SDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDV 142 Query: 443 KPDNVVLDVDDEGENGSPRARLADFGSAAWIGADGGRAEG 562 KP V+L EN +P +L FG A +G G A G Sbjct: 143 KPHCVLL---ASKENSAP-VKLGGFGVAIQLGESGLVAGG 178
>CSKP_RAT (Q62915) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (Calcium/calmodulin-dependent serine protein kinase) Length = 909 Score = 79.7 bits (195), Expect = 5e-15 Identities = 53/160 (33%), Positives = 77/160 (48%), Gaps = 2/160 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC +R TG+ FAVK VD + +++ + + +P +V++ Y Sbjct: 23 FSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYS 82 Query: 269 DDSWTHMVMDLCSGPDLLDWV--RLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDV 442 D +MV + G DL + R G E VA+ + Q+ +AL CH +IHRDV Sbjct: 83 SDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDV 142 Query: 443 KPDNVVLDVDDEGENGSPRARLADFGSAAWIGADGGRAEG 562 KP V+L EN +P +L FG A +G G A G Sbjct: 143 KPHCVLL---ASKENSAP-VKLGGFGVAIQLGESGLVAGG 178
>CDPK1_ORYSA (P53682) Calcium-dependent protein kinase, isoform 1 (EC 2.7.11.1)| (CDPK 1) Length = 534 Score = 79.3 bits (194), Expect = 7e-15 Identities = 45/131 (34%), Positives = 74/131 (56%), Gaps = 1/131 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG + CT STG +A K++ +SNL D E E ++ +G +V + YE Sbjct: 84 FGKTYLCTEISTGCQYACKTILKSNLRCVSDIEDVRREIQIMH-HLSGQKNIVTIKDTYE 142 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ H+VM+LC+G +L ++++ E AA+++ + + CH GV+HRD+KP Sbjct: 143 DEQAVHIVMELCAGGELFS--KIQKRGHYSERKAAELIKIIVGIIETCHSHGVMHRDLKP 200 Query: 449 DN-VVLDVDDE 478 +N ++LD DDE Sbjct: 201 ENFLLLDADDE 211
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 79.3 bits (194), Expect = 7e-15 Identities = 47/155 (30%), Positives = 83/155 (53%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T +AVK +D+S + E+ L +P ++ + VY+ Sbjct: 426 YSVCKRCVHKATDAEYAVKIIDKSKRDPSEEIEIL--------LRYGQHPNIITLKDVYD 477 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + ++VM+L G +LLD R+ R E A+D++ +A+ + H +GV+HRD+KP Sbjct: 478 DGKYVYLVMELMRGGELLD--RILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKP 535 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N++ E+G+P + R+ DFG A + A+ G Sbjct: 536 SNILY----MDESGNPESIRICDFGFAKQLRAENG 566 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/142 (28%), Positives = 77/142 (54%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + T G+ +A+K + ++ L DR +++E + LA +P +V++H ++ + Sbjct: 75 LVRKVTGSDAGQLYAMKVLKKATLKVR-DRVRSKMERDI--LAEVNHPFIVKLHYAFQTE 131 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+LA AL H G+I+RD+KP+N Sbjct: 132 GKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPEN 189 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++L D+EG ++ DFG Sbjct: 190 ILL--DEEG-----HIKITDFG 204
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 78.6 bits (192), Expect = 1e-14 Identities = 47/155 (30%), Positives = 81/155 (52%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T +AVK +D+S + E+ L +P ++ + VY+ Sbjct: 426 YSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEIL--------LRYGQHPNIITLKDVYD 477 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + ++VM+L G +LLD R+ R E A+D++ + + + H +GV+HRD+KP Sbjct: 478 DGKFVYLVMELMRGGELLD--RILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKP 535 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N++ E+GSP + R+ DFG A + A G Sbjct: 536 SNILY----RDESGSPESIRVCDFGFAKQLRAGNG 566 Score = 59.3 bits (142), Expect = 7e-09 Identities = 40/142 (28%), Positives = 76/142 (53%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + G+ +A+K + ++ L DR +++E + LA +P +V++H ++ + Sbjct: 75 LVRKVKGSDAGQLYAMKVLKKATLKVR-DRVRSKMERDI--LAEVNHPFIVKLHYAFQTE 131 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+LA AL H G+I+RD+KP+N Sbjct: 132 GKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPEN 189 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++L D+EG ++ DFG Sbjct: 190 ILL--DEEG-----HIKITDFG 204
>KS6A4_HUMAN (O75676) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB) Length = 772 Score = 77.4 bits (189), Expect = 3e-14 Identities = 51/147 (34%), Positives = 80/147 (54%), Gaps = 1/147 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V RC R +G+ FAVK + R L + RE+A + +L Q +P VV +H V+ Sbjct: 422 FSVCRRCRQRQSGQEFAVKILSR-RLEANTQREVAAL--RLCQ----SHPNVVNLHEVHH 474 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR-GVIHRDVK 445 D T++V++L G +LL+ +R +R E A+ I+ L A++ H GV+HRD+K Sbjct: 475 DQLHTYLVLELLRGGELLEHIRKKRH--FSESEASQILRSLVSAVSFMHEEAGVVHRDLK 532 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSA 526 P+N++ D G ++ DFG A Sbjct: 533 PENILYADDTPG----APVKIIDFGFA 555 Score = 43.1 bits (100), Expect = 5e-04 Identities = 30/125 (24%), Positives = 61/125 (48%), Gaps = 1/125 (0%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLD-RELAEIEPKLAQLAAAGNPGVVQVHAVYED 271 +V + G+ +A+K + ++ L +E E + +L P +V +H ++ Sbjct: 49 LVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQA-PFLVTLHYAFQT 107 Query: 272 DSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPD 451 D+ H+++D SG ++ + L + E ++ AL H+ G+I+RD+K + Sbjct: 108 DAKLHLILDYVSGGEM--FTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLE 165 Query: 452 NVVLD 466 NV+LD Sbjct: 166 NVLLD 170
>KS6A4_MOUSE (Q9Z2B9) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK) Length = 773 Score = 77.4 bits (189), Expect = 3e-14 Identities = 51/147 (34%), Positives = 80/147 (54%), Gaps = 1/147 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V RC R +G+ FAVK + R L ++ RE+A + +L Q +P VV +H V Sbjct: 422 FSVCRRCRQRQSGQEFAVKILSR-RLEENTQREVAAL--RLCQ----SHPNVVNLHEVLH 474 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR-GVIHRDVK 445 D T++V++L G +LL+ +R +R E A+ I+ L A++ H GV+HRD+K Sbjct: 475 DQLHTYLVLELLRGGELLEHIRKKR--LFSESEASQILRSLVSAVSFMHEEAGVVHRDLK 532 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSA 526 P+N++ D G ++ DFG A Sbjct: 533 PENILYADDTPG----APVKIIDFGFA 555 Score = 42.7 bits (99), Expect = 7e-04 Identities = 30/125 (24%), Positives = 61/125 (48%), Gaps = 1/125 (0%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLD-RELAEIEPKLAQLAAAGNPGVVQVHAVYED 271 +V + G+ +A+K + ++ L +E E + +L P +V +H ++ Sbjct: 49 LVRKTGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQA-PFLVTLHYAFQT 107 Query: 272 DSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPD 451 D+ H+++D SG ++ + L + E ++ AL H+ G+I+RD+K + Sbjct: 108 DAKLHLILDYVSGGEM--FTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLE 165 Query: 452 NVVLD 466 NV+LD Sbjct: 166 NVLLD 170
>PKH3_ASHGO (Q753D9) Serine/threonine-protein kinase PKH3 (EC 2.7.11.1)| Length = 726 Score = 77.4 bits (189), Expect = 3e-14 Identities = 49/159 (30%), Positives = 79/159 (49%), Gaps = 1/159 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPK-LAQLAAAGNPGVVQVHAVY 265 + V+R RS+ +A+K + ++ + + IE L L A +PG+++++ + Sbjct: 21 YSTVYRVVERSSQHQYAIKICSKRHIIGENKVKYVTIEKNTLNLLGQANHPGIIKLYYTF 80 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 D + VMDL G +LL LRR E A + QL + H GVIHRD+K Sbjct: 81 HDQENLYFVMDLAPGGELLQL--LRRQRVFSEAWARHYMCQLVDTVEYIHSMGVIHRDLK 138 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSAAWIGADGGRAEG 562 P+NV+LD + R +ADFG+A +G ++G Sbjct: 139 PENVLLDKEG-------RLMIADFGAAYTVGQSDAGSDG 170
>CDPK1_ARATH (Q06850) Calcium-dependent protein kinase, isoform AK1 (EC| 2.7.11.1) (CDPK) Length = 610 Score = 77.4 bits (189), Expect = 3e-14 Identities = 42/122 (34%), Positives = 65/122 (53%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG C ++TG+ FA KS+ + L D D E E ++ AG+P V+ + YE Sbjct: 161 FGTTFLCVEKTTGKEFACKSIAKRKLLTDEDVEDVRREIQIMH-HLAGHPNVISIKGAYE 219 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D H+VM+ C+G +L D R+ + E AA++ + + CH GV+HRD+KP Sbjct: 220 DVVAVHLVMECCAGGELFD--RIIQRGHYTERKAAELTRTIVGVVEACHSLGVMHRDLKP 277 Query: 449 DN 454 +N Sbjct: 278 EN 279
>KCC2A_DROME (Q00168) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) Length = 530 Score = 77.0 bits (188), Expect = 3e-14 Identities = 47/161 (29%), Positives = 84/161 (52%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F +V RC +STG FA K ++ L R+ ++E + +P +V++H + Sbjct: 25 FSIVKRCVQKSTGFEFAAKIINTKKLTA---RDFQKLEREARICRKLHHPNIVRLHDSIQ 81 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++++ ++V DL +G +L + + R E A+ + Q+ +++ CH+ GV+HRD+KP Sbjct: 82 EENYHYLVFDLVTGGELFEDIVAREF--YSEADASHCIQQILESVNHCHQNGVVHRDLKP 139 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 140 ENLLLASKAKG----AAVKLADFGLAIEVQGDHQAWFGFAG 176
>BRSK1_HUMAN (Q8TDC3) BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1| kinase) (SAD1A) Length = 794 Score = 76.3 bits (186), Expect = 6e-14 Identities = 44/136 (32%), Positives = 79/136 (58%) Frame = +2 Query: 122 TGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDL 301 TG+ A+K V+R L + + L ++E ++A L +P V+++H VYE+ + ++V++ Sbjct: 72 TGQKVAIKIVNREKLSESV---LMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEH 128 Query: 302 CSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEG 481 SG +L D++ +++G P+ A Q+ AL CH + HRD+KP+N++LD + Sbjct: 129 VSGGELFDYL-VKKGRLTPKE-ARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKN-- 184 Query: 482 ENGSPRARLADFGSAA 529 R+ADFG A+ Sbjct: 185 -----NIRIADFGMAS 195
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 76.3 bits (186), Expect = 6e-14 Identities = 46/168 (27%), Positives = 88/168 (52%) Frame = +2 Query: 35 SGELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLA 214 SG+L Y +G V++ + T + +A+K + L + ++R EIE Sbjct: 64 SGKLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKN-INRFFQEIEI--- 119 Query: 215 QLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLA 394 + +P +V+++ YE+D++ +++M+LCSG +L D + + G+ E AA I+ Q+ Sbjct: 120 -MKKLDHPNIVKLYETYENDNYIYLIMELCSGRELFDSI-IENGS-FTEKNAATIMKQIF 176 Query: 395 QALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIG 538 A+ H ++HRD+KP+N + + EN ++ DFG + +G Sbjct: 177 SAIFYLHSLNIVHRDLKPENFLF----QSENKDSLLKIIDFGLSKNLG 220
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 76.3 bits (186), Expect = 6e-14 Identities = 46/168 (27%), Positives = 88/168 (52%) Frame = +2 Query: 35 SGELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLA 214 SG+L Y +G V++ + T + +A+K + L + ++R EIE Sbjct: 64 SGKLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKN-INRFFQEIEI--- 119 Query: 215 QLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLA 394 + +P +V+++ YE+D++ +++M+LCSG +L D + + G+ E AA I+ Q+ Sbjct: 120 -MKKLDHPNIVKLYETYENDNYIYLIMELCSGRELFDSI-IENGS-FTEKNAATIMKQIF 176 Query: 395 QALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIG 538 A+ H ++HRD+KP+N + + EN ++ DFG + +G Sbjct: 177 SAIFYLHSLNIVHRDLKPENFLF----QSENKDSLLKIIDFGLSKNLG 220
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 75.9 bits (185), Expect = 7e-14 Identities = 42/159 (26%), Positives = 80/159 (50%) Frame = +2 Query: 44 LNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLA 223 L Y +G V R T R +G A+KS+ + + D+LD + I ++ ++ Sbjct: 52 LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELD--MVHIRREIEIMS 109 Query: 224 AAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQAL 403 + +P ++ ++ V+E+ ++M+ S +L D++ RR + E Q+ A+ Sbjct: 110 SLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRR--LSERETRHFFRQIVSAV 167 Query: 404 ALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 CH+ GV+HRD+K +N++LD + ++ADFG Sbjct: 168 HYCHKNGVVHRDLKLENILLD-------DNCNIKIADFG 199
>ROCK1_RAT (Q63644) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (p150 RhoA-binding kinase ROK beta) (Liver regeneration-related protein LRRG199) Length = 1369 Score = 75.5 bits (184), Expect = 1e-13 Identities = 54/165 (32%), Positives = 78/165 (47%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY FG V +ST + +A+K + + + D E + +A A Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 132 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 133 SPWVVQLFYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWARFYTAEVVLALDAI 189 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 H G IHRDVKPDN++LD S +LADFG+ + +G Sbjct: 190 HSMGFIHRDVKPDNMLLD-------KSGHLKLADFGTCMKMNKEG 227
>KS6A5_CHICK (Q5F3L1) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 789 Score = 75.5 bits (184), Expect = 1e-13 Identities = 47/146 (32%), Positives = 82/146 (56%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F + +C + T + +AVK + + + + RE+ + KL + G+P VV++H VY Sbjct: 427 FSICRKCLHKKTSQEYAVKIISK-RMEANTQREITAL--KLCE----GHPNVVKLHEVYH 479 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D T +VM+L G +LL+ R+++ E A+ I+ +L A++ H GV+HRD+KP Sbjct: 480 DQLHTFLVMELLKGGELLE--RIQKKQHFSETEASHIMRRLVSAVSHMHDVGVVHRDLKP 537 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N++ DE +N ++ DFG A Sbjct: 538 ENLLF--TDETDNS--EIKIIDFGFA 559 Score = 45.8 bits (107), Expect = 8e-05 Identities = 22/80 (27%), Positives = 45/80 (56%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V +H ++ D+ H+++D +G +L + L + E + ++ AL Sbjct: 101 SPFLVTLHYAFQTDTKLHLILDYINGGEL--FTHLSQRERFSENEVQIYIGEIVLALEHL 158 Query: 413 HRRGVIHRDVKPDNVVLDVD 472 H+ G+I+RD+K +N++LD D Sbjct: 159 HKLGIIYRDIKLENILLDSD 178
>ROCK1_RABIT (O77819) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (cAMP-dependent protein kinase ROCK-I) (CePKA) (Corneal epithelial Rho-associated-Ser/Thr kinase 1) (HEB Length = 1354 Score = 75.5 bits (184), Expect = 1e-13 Identities = 54/165 (32%), Positives = 78/165 (47%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY FG V +ST + +A+K + + + D E + +A A Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 132 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 133 SPWVVQLFYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWARFYTAEVVLALDAI 189 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 H G IHRDVKPDN++LD S +LADFG+ + +G Sbjct: 190 HSMGFIHRDVKPDNMLLD-------KSGHLKLADFGTCMKMNKEG 227
>ROCK1_MOUSE (P70335) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) Length = 1354 Score = 75.5 bits (184), Expect = 1e-13 Identities = 54/165 (32%), Positives = 78/165 (47%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY FG V +ST + +A+K + + + D E + +A A Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 132 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 133 SPWVVQLFYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWARFYTAEVVLALDAI 189 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 H G IHRDVKPDN++LD S +LADFG+ + +G Sbjct: 190 HSMGFIHRDVKPDNMLLD-------KSGHLKLADFGTCMKMNKEG 227
>ROCK1_HUMAN (Q13464) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen) Length = 1354 Score = 75.5 bits (184), Expect = 1e-13 Identities = 54/165 (32%), Positives = 78/165 (47%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY FG V +ST + +A+K + + + D E + +A A Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 132 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 133 SPWVVQLFYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWARFYTAEVVLALDAI 189 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 H G IHRDVKPDN++LD S +LADFG+ + +G Sbjct: 190 HSMGFIHRDVKPDNMLLD-------KSGHLKLADFGTCMKMNKEG 227
>CRK_DAUCA (P53681) CDPK-related protein kinase (EC 2.7.11.1) (PK421)| Length = 602 Score = 75.5 bits (184), Expect = 1e-13 Identities = 44/140 (31%), Positives = 76/140 (54%) Frame = +2 Query: 125 GEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLC 304 G+ AVK + ++ + + E E K+ + A G+ +VQ + +ED + ++VM+LC Sbjct: 174 GQDVAVKVIPKAKMTTAIAIEDVRREVKILR-ALTGHNNLVQFYDAFEDHTNVYVVMELC 232 Query: 305 SGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGE 484 G +LLD + L RG E A ++ Q+ +A CH +GV+HRD+KP+N + DE Sbjct: 233 EGGELLDRI-LSRGGKYTEDDAKAVMIQILNVVAFCHLQGVVHRDLKPENFLFKSKDE-- 289 Query: 485 NGSPRARLADFGSAAWIGAD 544 + + DFG + ++ D Sbjct: 290 --DSQLKAIDFGLSDYVKPD 307
>KGP2_RAT (Q64595) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 73.9 bits (180), Expect = 3e-13 Identities = 45/151 (29%), Positives = 80/151 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V ++ AFA+K + + ++ D +E E ++ L +P +V+++ ++ Sbjct: 464 FGRVELVKVKNENIAFAMKCIRKKHIVDTKQQEHVYSEKRI--LEELCSPFIVKLYRTFK 521 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ + +M+++ C G +L W LR EP + VA + +A HR G+I+RD+KP Sbjct: 522 DNKYVYMLLEACLGGEL--WSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKP 579 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +N++LD D +L DFG A IG+ Sbjct: 580 ENLILDADG-------YLKLVDFGFAKKIGS 603
>KCC2D_HUMAN (Q13557) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 499 Score = 73.9 bits (180), Expect = 3e-13 Identities = 47/161 (29%), Positives = 82/161 (50%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC TG+ +A K ++ L D + E E ++ +L +P +V++H Sbjct: 25 FSVVRRCMKIPTGQGYAAKIINTKKL-SARDHQKLEREARICRLLK--HPNIVRLHDSIS 81 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ + ++V DL +G +L + + R E A+ + Q+ +++ CH G++HRD+KP Sbjct: 82 EEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHLNGIVHRDLKP 139 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 140 ENLLLASKSKG----AAVKLADFGLAIEVQGDQQAWFGFAG 176
>KCC2D_RAT (P15791) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 533 Score = 73.6 bits (179), Expect = 4e-13 Identities = 47/161 (29%), Positives = 82/161 (50%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC TG+ +A K ++ L D + E E ++ +L +P +V++H Sbjct: 25 FSVVRRCMKIPTGQEYAAKIINTKKL-SARDHQKLEREARICRLLK--HPNIVRLHDSIS 81 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ + ++V DL +G +L + + R E A+ + Q+ +++ CH G++HRD+KP Sbjct: 82 EEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHLNGIVHRDLKP 139 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 140 ENLLLASKSKG----AAVKLADFGLAIEVQGDQQAWFGFAG 176
>KCC2B_RAT (P08413) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 73.6 bits (179), Expect = 4e-13 Identities = 49/161 (30%), Positives = 81/161 (50%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC TG +A K ++ L D + E E ++ +L N +V++H Sbjct: 25 FSVVRRCVKLCTGHEYAAKIINTKKL-SARDHQKLEREARICRLLKHSN--IVRLHDSIS 81 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ + ++V DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 82 EEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 139 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 140 ENLLLASKCKG----AAVKLADFGLAIEVQGDQQAWFGFAG 176
>KCC2B_MOUSE (P28652) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 73.6 bits (179), Expect = 4e-13 Identities = 49/161 (30%), Positives = 81/161 (50%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC TG +A K ++ L D + E E ++ +L N +V++H Sbjct: 25 FSVVRRCVKLCTGHEYAAKIINTKKL-SARDHQKLEREARICRLLKHSN--IVRLHDSIS 81 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ + ++V DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 82 EEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 139 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 140 ENLLLASKCKG----AAVKLADFGLAIEVQGDQQAWFGFAG 176
>KCC2B_HUMAN (Q13554) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 664 Score = 73.6 bits (179), Expect = 4e-13 Identities = 49/161 (30%), Positives = 81/161 (50%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC TG +A K ++ L D + E E ++ +L N +V++H Sbjct: 25 FSVVRRCVKLCTGHEYAAKIINTKKL-SARDHQKLEREARICRLLKHSN--IVRLHDSIS 81 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ + ++V DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 82 EEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 139 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 140 ENLLLASKCKG----AAVKLADFGLAIEVQGDQQAWFGFAG 176
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 73.6 bits (179), Expect = 4e-13 Identities = 41/159 (25%), Positives = 79/159 (49%) Frame = +2 Query: 44 LNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLA 223 L Y +G V R T R +G A+KS+ + + D+ D + I ++ ++ Sbjct: 51 LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQD--MVHIRREIEIMS 108 Query: 224 AAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQAL 403 + +P ++ ++ V+E+ ++M+ S +L D++ RR + E Q+ A+ Sbjct: 109 SLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRR--LSERETRHFFRQIVSAV 166 Query: 404 ALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 CH+ GV+HRD+K +N++LD + ++ADFG Sbjct: 167 HYCHKNGVVHRDLKLENILLD-------DNCNIKIADFG 198
>KPCD2_HUMAN (Q9BZL6) Serine/threonine-protein kinase D2 (EC 2.7.11.13)| (nPKC-D2) Length = 878 Score = 73.2 bits (178), Expect = 5e-13 Identities = 45/150 (30%), Positives = 79/150 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FGVV+ R TG AVK +D+ P ++ +++ ++A L + +PG+V + ++E Sbjct: 562 FGVVYGGKHRKTGRDVAVKVIDKLRFPT---KQESQLRNEVAILQSLRHPGIVNLECMFE 618 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 +VM+ G D+L+ + +PE + ++ Q+ AL H + ++H D+KP Sbjct: 619 TPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKP 677 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 +NV+L D P+ +L DFG A IG Sbjct: 678 ENVLLASADP----FPQVKLCDFGFARIIG 703
>BRSK2_HUMAN (Q8IWQ3) BR serine/threonine-protein kinase 2 (EC 2.7.11.1)| (Serine/threonine-protein kinase 29) (SAD1B) Length = 736 Score = 73.2 bits (178), Expect = 5e-13 Identities = 43/136 (31%), Positives = 78/136 (57%) Frame = +2 Query: 122 TGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDL 301 T + A+K V+R L + + L ++E ++A L +P V+++H VYE+ + ++V++ Sbjct: 41 TCQKVAIKIVNREKLSESV---LMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEH 97 Query: 302 CSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEG 481 SG +L D++ +++G P+ A Q+ AL CH + HRD+KP+N++LD + Sbjct: 98 VSGGELFDYL-VKKGRLTPKE-ARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKN-- 153 Query: 482 ENGSPRARLADFGSAA 529 R+ADFG A+ Sbjct: 154 -----NIRIADFGMAS 164
>KS6A5_PONPY (Q5R4K3) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 802 Score = 73.2 bits (178), Expect = 5e-13 Identities = 43/146 (29%), Positives = 82/146 (56%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F + +C + + +AFAVK + + + + +E+ + KL + G+P +V++H V+ Sbjct: 437 FSICRKCVHKKSNQAFAVKIISK-RMEANTQKEITAL--KLCE----GHPNIVKLHEVFH 489 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D T +VM+L +G +L + R+++ E A+ I+ +L A++ H GV+HRD+KP Sbjct: 490 DQLHTFLVMELLNGGELFE--RIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 547 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N++ EN + ++ DFG A Sbjct: 548 ENLLF----TDENDNLEIKIIDFGFA 569 Score = 47.8 bits (112), Expect = 2e-05 Identities = 34/150 (22%), Positives = 69/150 (46%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + + TG+ +A+K + ++ + + +P +V +H ++ + Sbjct: 65 LVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHTRQSPFLVTLHYAFQTE 124 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 + H+++D +G +L + L + E V ++ AL H+ G+I+RD+K +N Sbjct: 125 TKLHLILDYINGGEL--FTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLEN 182 Query: 455 VVLDVDDEGENGSPRARLADFGSAAWIGAD 544 ++LD NG L DFG + AD Sbjct: 183 ILLD-----SNG--HVMLTDFGLSKEFVAD 205
>KS6A5_HUMAN (O75582) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL) Length = 802 Score = 73.2 bits (178), Expect = 5e-13 Identities = 43/146 (29%), Positives = 82/146 (56%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F + +C + + +AFAVK + + + + +E+ + KL + G+P +V++H V+ Sbjct: 437 FSICRKCVHKKSNQAFAVKIISK-RMEANTQKEITAL--KLCE----GHPNIVKLHEVFH 489 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D T +VM+L +G +L + R+++ E A+ I+ +L A++ H GV+HRD+KP Sbjct: 490 DQLHTFLVMELLNGGELFE--RIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 547 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N++ EN + ++ DFG A Sbjct: 548 ENLLF----TDENDNLEIKIIDFGFA 569 Score = 46.6 bits (109), Expect = 5e-05 Identities = 34/150 (22%), Positives = 69/150 (46%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + + TG+ +A+K + ++ + + +P +V +H ++ + Sbjct: 65 LVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTE 124 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 + H+++D +G +L + L + E V ++ AL H+ G+I+RD+K +N Sbjct: 125 TKLHLILDYINGGEL--FTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLEN 182 Query: 455 VVLDVDDEGENGSPRARLADFGSAAWIGAD 544 ++LD NG L DFG + AD Sbjct: 183 ILLD-----SNG--HVVLTDFGLSKEFVAD 205
>DAPK3_RAT (O88764) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 72.8 bits (177), Expect = 6e-13 Identities = 46/154 (29%), Positives = 81/154 (52%), Gaps = 3/154 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDD---LDRELAEIEPKLAQLAAAGNPGVVQVHA 259 F +V +C + TG +A K + + LP + RE EIE +++ L +P ++ +H Sbjct: 24 FAIVRKCQQKGTGMEYAAKFIKKRRLPSSRRGVSRE--EIEREVSILREIRHPNIITLHD 81 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 V+E+ + ++++L SG +L D+ L + E A + Q+ + H + + H D Sbjct: 82 VFENKTDVVLILELVSGGELFDF--LAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFD 139 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +KP+N++L +D SPR +L DFG A I A Sbjct: 140 LKPENIML-LDKHA--ASPRIKLIDFGIAHRIEA 170
>DAPK3_MOUSE (O54784) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 72.8 bits (177), Expect = 6e-13 Identities = 46/154 (29%), Positives = 81/154 (52%), Gaps = 3/154 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDD---LDRELAEIEPKLAQLAAAGNPGVVQVHA 259 F +V +C + TG +A K + + LP + RE EIE +++ L +P ++ +H Sbjct: 24 FAIVRKCQQKGTGMEYAAKFIKKRRLPSSRRGVSRE--EIEREVSILREIRHPNIITLHD 81 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 V+E+ + ++++L SG +L D+ L + E A + Q+ + H + + H D Sbjct: 82 VFENKTDVVLILELVSGGELFDF--LAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFD 139 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +KP+N++L +D SPR +L DFG A I A Sbjct: 140 LKPENIML-LDKHA--ASPRIKLIDFGIAHRIEA 170
>KGP2_HUMAN (Q13237) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 72.8 bits (177), Expect = 6e-13 Identities = 44/151 (29%), Positives = 80/151 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V ++ AFA+K + + ++ D +E E ++ L +P +V+++ ++ Sbjct: 464 FGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRI--LEELCSPFIVKLYRTFK 521 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ + +M+++ C G +L W LR EP + VA + +A HR G+I+RD+KP Sbjct: 522 DNKYVYMLLEACLGGEL--WSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKP 579 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +N++LD + +L DFG A IG+ Sbjct: 580 ENLILDAEG-------YLKLVDFGFAKKIGS 603
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 72.4 bits (176), Expect = 8e-13 Identities = 47/155 (30%), Positives = 82/155 (52%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T FAVK +D+S + E+ L +P ++ + VY+ Sbjct: 433 YSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEIL--------LRYGQHPNIITLKDVYD 484 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + ++V +L G +LLD ++ R E A+ ++ + + + H +GV+HRD+KP Sbjct: 485 DGKYVYVVTELMKGGELLD--KILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKP 542 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N +L VD E+G+P + R+ DFG A + A+ G Sbjct: 543 SN-ILYVD---ESGNPESIRICDFGFAKQLRAENG 573 Score = 55.5 bits (132), Expect = 1e-07 Identities = 39/142 (27%), Positives = 74/142 (52%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + + + +A+K + ++ L DR ++E + L +P +V++H ++ + Sbjct: 84 LVKKISGSDARQLYAMKVLKKATLKVR-DRVRTKMERDI--LVEVNHPFIVKLHYAFQTE 140 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+LA AL H G+I+RD+KP+N Sbjct: 141 GKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPEN 198 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++L D+EG +L DFG Sbjct: 199 ILL--DEEG-----HIKLTDFG 213
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 72.4 bits (176), Expect = 8e-13 Identities = 47/155 (30%), Positives = 82/155 (52%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T FAVK +D+S + E+ L +P ++ + VY+ Sbjct: 433 YSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEIL--------LRYGQHPNIITLKDVYD 484 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + ++V +L G +LLD ++ R E A+ ++ + + + H +GV+HRD+KP Sbjct: 485 DGKYVYVVTELMKGGELLD--KILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKP 542 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N +L VD E+G+P + R+ DFG A + A+ G Sbjct: 543 SN-ILYVD---ESGNPESIRICDFGFAKQLRAENG 573 Score = 55.5 bits (132), Expect = 1e-07 Identities = 39/142 (27%), Positives = 74/142 (52%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + + + +A+K + ++ L DR ++E + L +P +V++H ++ + Sbjct: 84 LVKKISGSDARQLYAMKVLKKATLKVR-DRVRTKMERDI--LVEVNHPFIVKLHYAFQTE 140 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+LA AL H G+I+RD+KP+N Sbjct: 141 GKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPEN 198 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++L D+EG +L DFG Sbjct: 199 ILL--DEEG-----HIKLTDFG 213
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 72.4 bits (176), Expect = 8e-13 Identities = 46/155 (29%), Positives = 82/155 (52%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T +AVK +D+S + E+ L +P ++ + VY+ Sbjct: 446 YSVCKRCIHKTTNMEYAVKVIDKSKRDPSEEIEIL--------LRYGQHPNIITLKDVYD 497 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + ++V +L G +LLD ++ R E A+ ++ + + + H +GV+HRD+KP Sbjct: 498 DGKYVYLVTELMRGGELLD--KILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKP 555 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N +L VD E+G+P + R+ DFG A + A+ G Sbjct: 556 SN-ILYVD---ESGNPESIRICDFGFAKQLRAENG 586 Score = 58.2 bits (139), Expect = 2e-08 Identities = 42/142 (29%), Positives = 74/142 (52%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + T + +A+K + ++ L DR +IE + LA +P VV++H ++ + Sbjct: 96 LVRKITPPDSNHLYAMKVLKKATLKVR-DRVRTKIERDI--LADVNHPFVVKLHYAFQTE 152 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+LA L H G+I+RD+KP+N Sbjct: 153 GKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPEN 210 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++L D+EG +L DFG Sbjct: 211 ILL--DEEG-----HIKLTDFG 225
>MRCKG_HUMAN (Q6DT37) Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1)| (CDC42-binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma Length = 1551 Score = 72.4 bits (176), Expect = 8e-13 Identities = 53/154 (34%), Positives = 80/154 (51%), Gaps = 1/154 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDR-ELAEIEPKLAQLAAAGNPGVVQVHAVY 265 FG V R TG+ FA+K + + + L R E A + L + V +H + Sbjct: 82 FGEVTVVRQRDTGQIFAMKMLHKWEM---LKRAETACFREERDVLVKGDSRWVTTLHYAF 138 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 +D+ + ++VMD +G DLL + R +P +A +A++ A+ H+ G +HRDVK Sbjct: 139 QDEEYLYLVMDYYAGGDLLTLLS-RFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVK 197 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 PDNV+LDV NG RLADFGS + +G Sbjct: 198 PDNVLLDV-----NG--HIRLADFGSCLRLNTNG 224
>KPCD1_HUMAN (Q15139) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 912 Score = 72.4 bits (176), Expect = 8e-13 Identities = 44/150 (29%), Positives = 78/150 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG+V+ R TG A+K +D+ P ++ +++ ++A L +PGVV + ++E Sbjct: 594 FGIVYGGKHRKTGRDVAIKIIDKLRFPT---KQESQLRNEVAILQNLHHPGVVNLECMFE 650 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 +VM+ G D+L+ + +PE + ++ Q+ AL H + ++H D+KP Sbjct: 651 TPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKP 709 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 +NV+L D P+ +L DFG A IG Sbjct: 710 ENVLLASADP----FPQVKLCDFGFARIIG 735
>ROCK2_BOVIN (Q28021) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) Length = 1388 Score = 72.0 bits (175), Expect = 1e-12 Identities = 51/157 (32%), Positives = 78/157 (49%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY FG V +++ + +A+K + + + D E + +A A Sbjct: 91 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 148 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 149 SPWVVQLFCAFQDDKYLYMVMEYMPGGDL---VNLMSNYDVPEKWAKFYTAEVVLALDAI 205 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGS 523 H G+IHRDVKPDN++LD ++G +LADFG+ Sbjct: 206 HSMGLIHRDVKPDNMLLD-----KHG--HLKLADFGT 235
>CDKL1_MOUSE (Q8CEQ0) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 72.0 bits (175), Expect = 1e-12 Identities = 47/153 (30%), Positives = 77/153 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +GVV +C +R TG+ A+K + D + +++A E ++ L +P +V + V+ Sbjct: 15 YGVVFKCRNRDTGQIVAIKRFLETE-DDPVIKKIALREIRM--LKQLKHPNLVNLLEVFR 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 H+V + C L + R +RG VPEP+ +I Q QA+ CH+ IHRDVKP Sbjct: 72 RKRRLHLVFEYCDHTVLHELDRYQRG--VPEPLVKNITWQTLQAVNFCHKHNCIHRDVKP 129 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 +N+++ +L DFG A + G Sbjct: 130 ENILI-------TKQSAIKLCDFGFARLLTGPG 155
>ROCK2_RAT (Q62868) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) (RhoA-binding kinase 2) (p150 ROK-alpha) (ROKalpha) Length = 1379 Score = 71.6 bits (174), Expect = 1e-12 Identities = 51/157 (32%), Positives = 78/157 (49%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY FG V +++ + +A+K + + + D E + +A A Sbjct: 82 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 139 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 140 SPWVVQLFCAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWAKFYTAEVVLALDAI 196 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGS 523 H G+IHRDVKPDN++LD ++G +LADFG+ Sbjct: 197 HSMGLIHRDVKPDNMLLD-----KHG--HLKLADFGT 226
>KPCD3_HUMAN (O94806) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) (Protein kinase EPK2) Length = 890 Score = 71.6 bits (174), Expect = 1e-12 Identities = 43/150 (28%), Positives = 78/150 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG+V+ R TG A+K +D+ P ++ +++ ++A L +PG+V + ++E Sbjct: 587 FGIVYGGKHRKTGRDVAIKVIDKMRFPT---KQESQLRNEVAILQNLHHPGIVNLECMFE 643 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 +VM+ G D+L+ + + +PE + +V Q+ AL H + ++H D+KP Sbjct: 644 TPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKP 702 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 +NV+L P+ +L DFG A IG Sbjct: 703 ENVLL----ASAEPFPQVKLCDFGFARIIG 728
>ROCK2_MOUSE (P70336) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) Length = 1388 Score = 71.6 bits (174), Expect = 1e-12 Identities = 51/157 (32%), Positives = 78/157 (49%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY FG V +++ + +A+K + + + D E + +A A Sbjct: 91 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 148 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 149 SPWVVQLFCAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWAKFYTAEVVLALDAI 205 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGS 523 H G+IHRDVKPDN++LD ++G +LADFG+ Sbjct: 206 HSMGLIHRDVKPDNMLLD-----KHG--HLKLADFGT 235
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 71.6 bits (174), Expect = 1e-12 Identities = 46/169 (27%), Positives = 80/169 (47%), Gaps = 2/169 (1%) Frame = +2 Query: 47 NRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSN--LPDDLDRELAEIEPKLAQL 220 N Y F VV ++G+ +A+K +++ L R + ++ L Sbjct: 164 NSHYEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDIL 223 Query: 221 AAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 + +PGVVQ H ++E+D +VM+ G DL+D+ L + E ++ QL + Sbjct: 224 KSLHHPGVVQCHEIFENDDELFIVMEYVEGGDLMDF--LIANGSIDEQDCKPLLKQLLET 281 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 L H++GV HRD+KP+N+++ D +++DFG A I G Sbjct: 282 LLHLHKQGVTHRDIKPENILITNDF-------HLKISDFGLAKVIHGTG 323
>KPCD1_MOUSE (Q62101) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 918 Score = 71.6 bits (174), Expect = 1e-12 Identities = 44/150 (29%), Positives = 78/150 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG+V+ R TG A+K +D+ P ++ +++ ++A L +PGVV + ++E Sbjct: 600 FGIVYGGKHRKTGRDVAIKIIDKLRFPT---KQESQLRNEVAILQNLHHPGVVNLECMFE 656 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 +VM+ G D+L+ + +PE + ++ Q+ AL H + ++H D+KP Sbjct: 657 TPERVFVVMEKLHG-DMLEMILSSEKGWLPEHITKFLITQILVALRHLHFKNIVHCDLKP 715 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 +NV+L D P+ +L DFG A IG Sbjct: 716 ENVLLASADP----FPQVKLCDFGFARIIG 741
>KPCD3_MOUSE (Q8K1Y2) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) Length = 889 Score = 71.6 bits (174), Expect = 1e-12 Identities = 43/150 (28%), Positives = 78/150 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG+V+ R TG A+K +D+ P ++ +++ ++A L +PG+V + ++E Sbjct: 586 FGIVYGGKHRKTGRDVAIKVIDKMRFPT---KQESQLRNEVAILQNLHHPGIVNLECMFE 642 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 +VM+ G D+L+ + + +PE + +V Q+ AL H + ++H D+KP Sbjct: 643 TPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKP 701 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 +NV+L P+ +L DFG A IG Sbjct: 702 ENVLL----ASAEPFPQVKLCDFGFARIIG 727
>CIPK1_ARATH (Q8RWC9) CBL-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (SOS2-like protein kinase PKS13) (SNF1-related kinase 3.16) Length = 444 Score = 71.6 bits (174), Expect = 1e-12 Identities = 51/175 (29%), Positives = 83/175 (47%) Frame = +2 Query: 5 RKPEENH*TMSGELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDR 184 R+ EE G Y FG V +G +FAVK +D+S + D L+ Sbjct: 3 RRQEEEKKAEKGMRLGKYELGRTLGEGNFGKVKFAKDTVSGHSFAVKIIDKSRIAD-LNF 61 Query: 185 ELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEP 364 L +I+ ++ L +P +V++H V + +MVM+L +G +L D R+ + E Sbjct: 62 SL-QIKREIRTLKMLKHPHIVRLHEVLASKTKINMVMELVTGGELFD--RIVSNGKLTET 118 Query: 365 VAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 + QL ++ CH +GV HRD+K +NV+LD ++ DFG +A Sbjct: 119 DGRKMFQQLIDGISYCHSKGVFHRDLKLENVLLD-------AKGHIKITDFGLSA 166
>KGP2_MOUSE (Q61410) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 71.6 bits (174), Expect = 1e-12 Identities = 44/151 (29%), Positives = 79/151 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V ++ AFA+K + + ++ D +E E ++ L +P +V+++ ++ Sbjct: 464 FGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRI--LEELCSPFIVKLYRTFK 521 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ + +M+++ C G +L W LR EP + VA + +A H G+I+RD+KP Sbjct: 522 DNKYVYMLLEACLGGEL--WSILRDRGSFDEPTSKFCVACVTEAFDYLHLLGIIYRDLKP 579 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +N++LD D +L DFG A IG+ Sbjct: 580 ENLILDADG-------YLKLVDFGFAKKIGS 603
>KCC2A_RAT (P11275) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 71.2 bits (173), Expect = 2e-12 Identities = 47/161 (29%), Positives = 81/161 (50%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC G+ +A K ++ L D + E E ++ +L +P +V++H Sbjct: 24 FSVVRRCVKVLAGQEYAAKIINTKKL-SARDHQKLEREARICRLLK--HPNIVRLHDSIS 80 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ +++ DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 81 EEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 138 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 139 ENLLLASKLKG----AAVKLADFGLAIEVEGEQQAWFGFAG 175
>KCC2A_PONPY (Q5RCC4) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 71.2 bits (173), Expect = 2e-12 Identities = 47/161 (29%), Positives = 81/161 (50%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC G+ +A K ++ L D + E E ++ +L +P +V++H Sbjct: 24 FSVVRRCVKVLAGQEYAAKIINTKKL-SARDHQKLEREARICRLLK--HPNIVRLHDSIS 80 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ +++ DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 81 EEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 138 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 139 ENLLLASKLKG----AAVKLADFGLAIEVEGEQQAWFGFAG 175
>KCC2A_HUMAN (Q9UQM7) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 71.2 bits (173), Expect = 2e-12 Identities = 47/161 (29%), Positives = 81/161 (50%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC G+ +A K ++ L D + E E ++ +L +P +V++H Sbjct: 24 FSVVRRCVKVLAGQEYAAKIINTKKL-SARDHQKLEREARICRLLK--HPNIVRLHDSIS 80 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ +++ DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 81 EEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 138 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 139 ENLLLASKLKG----AAVKLADFGLAIEVEGEQQAWFGFAG 175
>ROCK2_HUMAN (O75116) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2) Length = 1388 Score = 70.9 bits (172), Expect = 2e-12 Identities = 51/157 (32%), Positives = 78/157 (49%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY FG V +++ + +A+K + + + D E + +A A Sbjct: 91 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 148 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 149 SPWVVQLFYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWAKFYTAEVVLALDAI 205 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGS 523 H G+IHRDVKPDN++LD ++G +LADFG+ Sbjct: 206 HSMGLIHRDVKPDNMLLD-----KHG--HLKLADFGT 235
>CDKL1_RAT (Q66HE7) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 70.9 bits (172), Expect = 2e-12 Identities = 47/153 (30%), Positives = 77/153 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +GVV +C +R TG+ A+K + D + +++A E ++ L +P +V + V+ Sbjct: 15 YGVVFKCRNRDTGQIVAIKRFLETE-DDPVIKKIALREIRM--LKQLKHPNLVSLLEVFR 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 H+V + C L + R +RG VPEP+ +I Q QA+ CH+ IHRDVKP Sbjct: 72 RKRRLHLVFEYCHHTVLHELDRYQRG--VPEPLVKNITWQTLQAVNFCHKHNCIHRDVKP 129 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 +N+++ +L DFG A + G Sbjct: 130 ENILITKHSV-------IKLCDFGFARLLTGPG 155
>KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC 2.7.11.11) (PKA| 3) Length = 398 Score = 70.5 bits (171), Expect = 3e-12 Identities = 48/178 (26%), Positives = 85/178 (47%), Gaps = 1/178 (0%) Frame = +2 Query: 5 RKPEENH*TMSGELN-RDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLD 181 +KP + SG+ + D+ FG VH S G +A+K++ + + Sbjct: 70 KKPMLQYRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQ 129 Query: 182 RELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPE 361 E E ++ L+ +P ++++ ++D MVMD G +L LR+ P Sbjct: 130 VEHTNDERRM--LSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSL--LRKSQRFPN 185 Query: 362 PVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWI 535 PVA A++ AL H + +I+RD+KP+N++LD +NG ++ DFG A ++ Sbjct: 186 PVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLD-----KNG--HIKITDFGFAKYV 236
>DMPK_HUMAN (Q09013) Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy| protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK) Length = 639 Score = 70.5 bits (171), Expect = 3e-12 Identities = 44/145 (30%), Positives = 79/145 (54%), Gaps = 1/145 (0%) Frame = +2 Query: 116 RSTGEAFAVKSVDRSNLPDDLDR-ELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMV 292 + TG+ +A+K +++ ++ L R E++ + L + Q+H ++D+++ ++V Sbjct: 101 KQTGQVYAMKIMNKWDM---LKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLV 157 Query: 293 MDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVD 472 M+ G DLL + + G +P +A +A++ A+ HR G +HRD+KPDN++LD Sbjct: 158 MEYYVGGDLLTLLS-KFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLD-- 214 Query: 473 DEGENGSPRARLADFGSAAWIGADG 547 RLADFGS + ADG Sbjct: 215 -----RCGHIRLADFGSCLKLRADG 234
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 70.5 bits (171), Expect = 3e-12 Identities = 46/155 (29%), Positives = 81/155 (52%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T +AVK +D+S + E+ L +P ++ + VY+ Sbjct: 429 YSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEIL--------LRYGQHPNIITLKDVYD 480 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D ++V +L G +LLD ++ R E A+ ++ +++ + H +GV+HRD+KP Sbjct: 481 DSKHVYLVTELMRGGELLD--KILRQKFFSEREASFVLYTISKTVEYLHSQGVVHRDLKP 538 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N +L VD E+G+P R+ DFG A + A+ G Sbjct: 539 SN-ILYVD---ESGNPECLRICDFGFAKQLRAENG 569 Score = 58.9 bits (141), Expect = 9e-09 Identities = 42/142 (29%), Positives = 74/142 (52%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + T G +A+K + ++ L DR ++E + LA +P VV++H ++ + Sbjct: 78 LVRKVTRPDNGHLYAMKVLKKATLKVR-DRVRTKMERDI--LADVNHPFVVKLHYAFQTE 134 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+LA L H G+I+RD+KP+N Sbjct: 135 GKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPEN 192 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++L D+EG +L DFG Sbjct: 193 ILL--DEEG-----HIKLTDFG 207
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 70.1 bits (170), Expect = 4e-12 Identities = 46/155 (29%), Positives = 81/155 (52%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T +AVK +D+S + E+ L +P ++ + VY+ Sbjct: 418 YSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEIL--------LRYGQHPNIITLKDVYD 469 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D ++V +L G +LLD ++ R E A+ ++ +++ + H +GV+HRD+KP Sbjct: 470 DGKHVYLVTELMRGGELLD--KILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKP 527 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N +L VD E+G+P R+ DFG A + A+ G Sbjct: 528 SN-ILYVD---ESGNPECLRICDFGFAKQLRAENG 558 Score = 59.3 bits (142), Expect = 7e-09 Identities = 42/142 (29%), Positives = 75/142 (52%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + T +G +A+K + ++ L DR ++E + LA +P VV++H ++ + Sbjct: 78 LVRKVTRPDSGHLYAMKVLKKATLKVR-DRVRTKMERDI--LADVNHPFVVKLHYAFQTE 134 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+LA L H G+I+RD+KP+N Sbjct: 135 GKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPEN 192 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++L D+EG +L DFG Sbjct: 193 ILL--DEEG-----HIKLTDFG 207
>CBK1_KLULA (P31034) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 718 Score = 70.1 bits (170), Expect = 4e-12 Identities = 42/156 (26%), Positives = 80/156 (51%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V + TG+ +A+K++ +S + + +LA ++ + LA + Sbjct: 302 DFNSVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYNK--DQLAHVKAERDVLAGSD 359 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VV ++ ++D + +++M+ G DL+ L R E V +A+ A+ + Sbjct: 360 SPWVVSLYYSFQDSQYLYLIMEFLPGGDLM--TMLIRWQIFTEDVTRFYMAECILAIEVI 417 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D+ +L+DFG Sbjct: 418 HKLGFIHRDIKPDNILIDI-------RGHIKLSDFG 446
>KPC1_APLCA (Q16974) Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I)| Length = 649 Score = 69.7 bits (169), Expect = 5e-12 Identities = 46/156 (29%), Positives = 78/156 (50%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V + T E +A+K + + + D D E IE ++ L Sbjct: 319 DFNFLTVLGKGSFGKVVLAERKGTDELYAIKILKKDVIIQDDDVECTMIEKRVLALPDKP 378 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 P +VQ+H+ ++ + VM+ +G DL+ R+++ EPVAA A++A L Sbjct: 379 -PFLVQLHSCFQTMDRLYFVMEYVNGGDLM--YRIQQEGKFKEPVAAFYAAEIAIGLFYL 435 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H +G+++RD+K DNV+LD + ++ADFG Sbjct: 436 HTQGIVYRDLKLDNVMLDAEG-------HIKIADFG 464
>KPCZ_RABIT (O19111) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 591 Score = 69.7 bits (169), Expect = 5e-12 Identities = 42/135 (31%), Positives = 74/135 (54%) Frame = +2 Query: 116 RSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVM 295 + G+ +A+K V + + DD D + + E + + A+GNP +V +H+ ++ S +V+ Sbjct: 271 KKNGQVYAMKVVKKELVHDDEDIDWVQTEKHVFE-QASGNPFLVGLHSCFQTTSRLFLVI 329 Query: 296 DLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDD 475 + +G DL+ ++R +PE A A++ AL H RG+I+RD+K DNV+LD D Sbjct: 330 EYVNGGDLM--FHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADG 387 Query: 476 EGENGSPRARLADFG 520 +L D+G Sbjct: 388 -------HIKLTDYG 395
>NEK1_MOUSE (P51954) Serine/threonine-protein kinase Nek1 (EC 2.7.11.1)| (NimA-related protein kinase 1) Length = 1203 Score = 69.3 bits (168), Expect = 7e-12 Identities = 44/146 (30%), Positives = 68/146 (46%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG S G + +K ++ S + D +E E ++A LA +P +VQ +E Sbjct: 15 FGKAVLVKSTEDGRHYVIKEINISRMSD---KERQESRREVAVLANMKHPNIVQYKESFE 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ ++VMD C G DL + ++GA E D Q+ AL H R ++HRD+K Sbjct: 72 ENGSLYIVMDYCEGGDLFKRINAQKGALFQEDQILDWFVQICLALKHVHDRKILHRDIKS 131 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 N+ L D +L DFG A Sbjct: 132 QNIFLTKDG-------TVQLGDFGIA 150
>PHKG2_HUMAN (P15735) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3) Length = 406 Score = 69.3 bits (168), Expect = 7e-12 Identities = 46/147 (31%), Positives = 76/147 (51%), Gaps = 5/147 (3%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSN---LPDDLD--RELAEIEPKLAQLAAAGNPGVVQVHA 259 VV RC R+TG FAVK ++ + P+ L+ RE E + + AG+P ++ + Sbjct: 37 VVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR-QVAGHPHIITLID 95 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 YE S+ +V DL +L D+ L + E I+ L +A++ H ++HRD Sbjct: 96 SYESSSFMFLVFDLMRKGELFDY--LTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRD 153 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFG 520 +KP+N++LD + + RL+DFG Sbjct: 154 LKPENILLD-------DNMQIRLSDFG 173
>KCCS_MALDO (Q07250) Calcium/calmodulin-dependent serine/threonine-protein| kinase (EC 2.7.11.17) Length = 415 Score = 69.3 bits (168), Expect = 7e-12 Identities = 32/74 (43%), Positives = 50/74 (67%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P V+ ++ VYED++ H+V++LCSG +L D R+ + E AA +V Q+AQ LA Sbjct: 107 HPNVIDLYDVYEDENGVHLVLELCSGGELFD--RIVKQERYSEVGAAAVVRQIAQGLAAL 164 Query: 413 HRRGVIHRDVKPDN 454 HR ++HRD+KP+N Sbjct: 165 HRSNIVHRDLKPEN 178
>DMPK_MOUSE (P54265) Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy| protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK) Length = 631 Score = 68.9 bits (167), Expect = 9e-12 Identities = 43/145 (29%), Positives = 78/145 (53%), Gaps = 1/145 (0%) Frame = +2 Query: 116 RSTGEAFAVKSVDRSNLPDDLDR-ELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMV 292 + TG+ +A+K +++ ++ L R E++ + L + Q+H ++D+++ ++V Sbjct: 91 KQTGQVYAMKIMNKWDM---LKRGEVSCFREERDVLVKGDRRWITQLHFAFQDENYLYLV 147 Query: 293 MDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVD 472 M+ G DLL + + G +P +A +A++ A+ HR G +HRD+KPDN++LD Sbjct: 148 MEYYVGGDLLTLLS-KFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLD-- 204 Query: 473 DEGENGSPRARLADFGSAAWIGADG 547 RLADFGS + DG Sbjct: 205 -----RCGHIRLADFGSCLKLQPDG 224
>PKAB_STRCO (P54740) Serine/threonine protein kinase pkaB (EC 2.7.11.1)| Length = 417 Score = 68.9 bits (167), Expect = 9e-12 Identities = 49/128 (38%), Positives = 65/128 (50%), Gaps = 1/128 (0%) Frame = +2 Query: 155 RSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVR 334 R +L D + ++ + A L +P VV V + D + +VMDL G DL R Sbjct: 39 REDLASDQELVSRFVQERTA-LLGLDHPHVVSVRDLVVDGNDLALVMDLVRGTDLR--TR 95 Query: 335 LRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDE-GENGSPRARLA 511 L R + A +VA +A LA H GV+HRDVKP+NV+LD+ G GS A L Sbjct: 96 LDRERRLAPEAAVAVVADVADGLAAAHAAGVVHRDVKPENVLLDMQGPLGPGGSHPALLT 155 Query: 512 DFGSAAWI 535 DFG A I Sbjct: 156 DFGVAKLI 163
>CBK1_DEBHA (Q6BLJ9) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 716 Score = 68.9 bits (167), Expect = 9e-12 Identities = 42/156 (26%), Positives = 78/156 (50%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V R TG+ +A+K++ +S + +LA ++ + LA + Sbjct: 314 DFNTVKVIGKGAFGEVRLVQKRDTGKIYAMKTLLKSEMYKK--DQLAHVKAERDVLAGSD 371 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VV ++ ++D + +++M+ G DL+ L R E + +A+ A+ Sbjct: 372 SPWVVSLYYSFQDAQYLYLIMEFLPGGDLM--TMLIRWQIFTEDITRFYMAECVLAIEAI 429 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D+ +L+DFG Sbjct: 430 HKLGFIHRDIKPDNILIDI-------RGHIKLSDFG 458
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1)| (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 68.9 bits (167), Expect = 9e-12 Identities = 47/154 (30%), Positives = 79/154 (51%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC +T FAVK +D+S E EI + Q +P ++ + V++ Sbjct: 437 YSVCKRCIHATTNMEFAVKIIDKSKRDPS---EEIEILMRYGQ-----HPNIITLKDVFD 488 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + ++V DL G +LLD R+ + E A+DI+ +++ + H +GV+HRD+KP Sbjct: 489 DGRYVYLVTDLMKGGELLD--RILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKP 546 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADGG 550 N +L +D+ S R+ DFG A + + G Sbjct: 547 SN-ILYMDESASADS--IRICDFGFAKQLRGENG 577 Score = 56.6 bits (135), Expect = 5e-08 Identities = 39/142 (27%), Positives = 76/142 (53%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + T G+ +A+K + +++L DR ++E + L +P +V++H ++ + Sbjct: 89 LVRKKTGPDAGQLYAMKVLKKASLKVR-DRVRTKMERDI--LVEVNHPFIVKLHYAFQTE 145 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G D+ + RL + E +A+LA AL H+ G+++RD+KP+N Sbjct: 146 GKLYLILDFLRGGDV--FTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPEN 203 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++LD E G +L DFG Sbjct: 204 ILLD-----EIG--HIKLTDFG 218
>CDKL1_BRARE (Q6AXJ9) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 350 Score = 68.6 bits (166), Expect = 1e-11 Identities = 45/146 (30%), Positives = 74/146 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +GVV +C ++ TG+ A+K S D + +++A E ++ L +P +V + V+ Sbjct: 15 YGVVFKCRNKDTGQIVAIKKFVESE-DDPIIKKIALREIRM--LKQLKHPNLVNLMEVFR 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 H+V + C L + R RG VPE + I+ Q QA+ CH++ IHRDVKP Sbjct: 72 RKRKLHLVFEYCDHTVLNELDRYPRG--VPEHMVKSIIWQTLQAVNFCHKQNCIHRDVKP 129 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N+++ +L DFG A Sbjct: 130 ENILITKHQV-------IKLCDFGFA 148
>KS6AB_XENLA (P10666) Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1)| (Ribosomal protein S6 kinase II beta) (S6KII-beta) (P90-RSK) Length = 629 Score = 68.6 bits (166), Expect = 1e-11 Identities = 47/154 (30%), Positives = 79/154 (51%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC + T +AVK +D+S E EI + Q +P ++ + VYE Sbjct: 427 YSVCKRCVHKGTNMEYAVKVIDKSKRDPS---EEIEILRRYGQ-----HPNIITLKDVYE 478 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + + ++V +L G +LLD R+ R E A ++ + + + H +GV+HRD+KP Sbjct: 479 ECNSIYLVTELMRGGELLD--RILRQKFFSEREACSVLFTVCKTVEYLHSQGVVHRDLKP 536 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADGG 550 N +L VD+ G+ S R+ DFG + + A+ G Sbjct: 537 SN-ILYVDESGDPES--IRICDFGFSKQLRAENG 567 Score = 56.6 bits (135), Expect = 5e-08 Identities = 41/142 (28%), Positives = 74/142 (52%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + T + +A+K + ++ L DR ++E + LA +P VV++H ++ + Sbjct: 78 LVRKITPPDANQLYAMKVLKKATLKVR-DRVRTKMERDI--LADVHHPFVVRLHYAFQTE 134 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+LA L H G+I+RD+KP+N Sbjct: 135 GKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPEN 192 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++L D+EG +L DFG Sbjct: 193 ILL--DEEG-----HIKLTDFG 207
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 68.6 bits (166), Expect = 1e-11 Identities = 46/154 (29%), Positives = 78/154 (50%), Gaps = 5/154 (3%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQ-----LAAAGNPGVVQVHA 259 VV RC R+TG+ FAVK ++ S L+ +L E+ + AG+P ++ + Sbjct: 37 VVRRCVHRATGDEFAVKIMEVSAERLSLE-QLEEVRDATRREMHILRQVAGHPHIITLID 95 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 YE S+ +V DL +L D+ L + E I+ L +A++ H ++HRD Sbjct: 96 SYESSSFMFLVFDLMRKGELFDY--LTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRD 153 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +KP+N++LD + + RL+DFG + + A Sbjct: 154 LKPENILLD-------DNMQIRLSDFGFSCHLEA 180
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 68.6 bits (166), Expect = 1e-11 Identities = 47/158 (29%), Positives = 84/158 (53%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V+ TG++ A+K +D+ + E +I+ +++ + +P +V++H V Sbjct: 23 FAKVYHARHLKTGDSVAIKVIDKERILKVGMTE--QIKREISAMRLLRHPNIVELHEVMA 80 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S + VM+ G +L + V + + E VA QL +A+ CH RGV HRD+KP Sbjct: 81 TKSKIYFVMEHVKGGELFNKVSTGK---LREDVARKYFQQLVRAVDFCHSRGVCHRDLKP 137 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADGGRAEG 562 +N++LD E+G+ +++DFG +A +D R +G Sbjct: 138 ENLLLD-----EHGN--LKISDFGLSAL--SDSRRQDG 166
>MRCKG_MOUSE (Q80UW5) Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1)| (CDC42-binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma Length = 1551 Score = 68.6 bits (166), Expect = 1e-11 Identities = 50/154 (32%), Positives = 80/154 (51%), Gaps = 1/154 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDR-ELAEIEPKLAQLAAAGNPGVVQVHAVY 265 FG V R +G+ FA+K + + + L R E A + L + V +H + Sbjct: 82 FGEVAVVRQRGSGQIFAMKMLHKWEM---LKRAETACFREERDVLVKGDSRWVTALHYAF 138 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 +D+ + ++VMD +G DLL + R +P +A +A++ A+ H+ G +HRDVK Sbjct: 139 QDEEYLYLVMDYYAGGDLLTLLS-RFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVK 197 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 PDN++LD+ NG RLADFGS + +G Sbjct: 198 PDNILLDM-----NG--HIRLADFGSCLRLNNNG 224
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 68.6 bits (166), Expect = 1e-11 Identities = 47/154 (30%), Positives = 80/154 (51%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC + T +AVK +D++ E EI + Q +P ++ + VY+ Sbjct: 427 YSVCKRCVHKGTNMEYAVKVIDKTKRDPS---EEIEILRRYGQ-----HPNIIALKDVYK 478 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + + ++V +L G +LLD R+ R E A+ ++ + + + H +GV+HRD+KP Sbjct: 479 EGNSIYVVTELMRGGELLD--RILRQKFFSEREASSVLFTVCKTVENLHSQGVVHRDLKP 536 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADGG 550 N +L VD+ G+ S R+ DFG A + AD G Sbjct: 537 SN-ILYVDESGDPES--IRICDFGFAKQLRADNG 567 Score = 56.6 bits (135), Expect = 5e-08 Identities = 41/142 (28%), Positives = 74/142 (52%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + T + +A+K + ++ L DR ++E + LA +P VV++H ++ + Sbjct: 78 LVRKITPPDANQLYAMKVLKKATLKVR-DRVRTKMERDI--LADVHHPFVVRLHYAFQTE 134 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+LA L H G+I+RD+KP+N Sbjct: 135 GKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPEN 192 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++L D+EG +L DFG Sbjct: 193 ILL--DEEG-----HIKLTDFG 207
>DAPK3_HUMAN (O43293) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 454 Score = 68.6 bits (166), Expect = 1e-11 Identities = 43/154 (27%), Positives = 81/154 (52%), Gaps = 3/154 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDD---LDRELAEIEPKLAQLAAAGNPGVVQVHA 259 F +V +C + TG+ +A K + + L + RE EIE ++ L +P ++ +H Sbjct: 24 FAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSRE--EIEREVNILREIRHPNIITLHD 81 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 ++E+ + ++++L SG +L D++ + + E A + Q+ + H + + H D Sbjct: 82 IFENKTDVVLILELVSGGELFDFLAEKES--LTEDEATQFLKQILDGVHYLHSKRIAHFD 139 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +KP+N++L +D N PR +L DFG A I A Sbjct: 140 LKPENIML-LDKNVPN--PRIKLIDFGIAHKIEA 170
>CDKL1_HUMAN (Q00532) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIALRE) (Protein kinase p42 KKIALRE) Length = 357 Score = 68.2 bits (165), Expect = 2e-11 Identities = 46/146 (31%), Positives = 73/146 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +GVV +C +R TG+ A+K S D + +++A E ++ L +P +V + V+ Sbjct: 15 YGVVFKCRNRDTGQIVAIKKFLESE-DDPVIKKIALREIRM--LKQLKHPNLVNLLEVFR 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 H+V + C L + R +RG VPE + I Q QA+ CH+ IHRDVKP Sbjct: 72 RKRRLHLVFEYCDHTVLHELDRYQRG--VPEHLVKSITWQTLQAVNFCHKHNCIHRDVKP 129 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N+++ +L DFG A Sbjct: 130 ENILITKHSV-------IKLCDFGFA 148
>CAKI_DROME (Q24210) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CAKI) (Peripheral plasma membrane protein CaMGUK) Length = 898 Score = 68.2 bits (165), Expect = 2e-11 Identities = 45/148 (30%), Positives = 69/148 (46%), Gaps = 2/148 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F +V RC R + + FAVK VD + A+++ + +P +V++ Y Sbjct: 23 FSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHMLKHPHIVELLETYS 82 Query: 269 DDSWTHMVMDLCSGPDLLDWV--RLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDV 442 + +MV + G DL V R G E VA + Q+ +AL CH ++HRDV Sbjct: 83 SEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHENDILHRDV 142 Query: 443 KPDNVVLDVDDEGENGSPRARLADFGSA 526 +P +L D N +P +L FGSA Sbjct: 143 RPACALLATVD---NSAP-VKLGGFGSA 166
>LOK_DROME (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC| 2.7.11.1) (Protein loki) (dMNK) Length = 476 Score = 67.8 bits (164), Expect = 2e-11 Identities = 48/176 (27%), Positives = 84/176 (47%), Gaps = 8/176 (4%) Frame = +2 Query: 41 ELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLP--------DDLDRELAE 196 E+N+ Y +G+V T + FA+K V ++ L D DR L E Sbjct: 169 EINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNE 228 Query: 197 IEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAAD 376 + + +P VV++H + + +MV++ G DLL+ R+ + E ++ Sbjct: 229 AKI----MKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLN--RIISNKLLSEDISKL 282 Query: 377 IVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGAD 544 Q+ A+ H RG+ HRD+KPDNV+L+ +DE +++DFG + ++ D Sbjct: 283 YFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDE----ETLLKVSDFGLSKFVQKD 334
>CBK1_ASHGO (Q754N7) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 719 Score = 67.8 bits (164), Expect = 2e-11 Identities = 42/156 (26%), Positives = 78/156 (50%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V + TG+ +A+K++ +S + +LA ++ + LA + Sbjct: 309 DFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKK--DQLAHVKAERDVLAGSD 366 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VV ++ ++D + +++M+ G DL+ L R E V +A+ A+ Sbjct: 367 SPWVVSLYYSFQDAQYLYLIMEFLPGGDLM--TMLIRWQIFTEDVTRFYMAECILAIEAI 424 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D+ +L+DFG Sbjct: 425 HKLGFIHRDIKPDNILIDI-------RGHIKLSDFG 453
>CBK1_YEAST (P53894) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1) (Cell| wall biosynthesis kinase) Length = 756 Score = 67.8 bits (164), Expect = 2e-11 Identities = 42/156 (26%), Positives = 78/156 (50%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V + TG+ +A+K++ +S + +LA ++ + LA + Sbjct: 351 DFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKK--DQLAHVKAERDVLAGSD 408 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VV ++ ++D + +++M+ G DL+ L R E V +A+ A+ Sbjct: 409 SPWVVSLYYSFQDAQYLYLIMEFLPGGDLM--TMLIRWQLFTEDVTRFYMAECILAIETI 466 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D+ +L+DFG Sbjct: 467 HKLGFIHRDIKPDNILIDI-------RGHIKLSDFG 495
>PKAA_STRCO (P54739) Serine/threonine protein kinase pkaA (EC 2.7.11.1)| Length = 543 Score = 67.8 bits (164), Expect = 2e-11 Identities = 49/141 (34%), Positives = 69/141 (48%) Frame = +2 Query: 125 GEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLC 304 GE A+K V + L D D + + + L +P +V+V + + +VMDL Sbjct: 42 GETVAIK-VLKEELASDADIVMRFLRERSVLLRLT-HPNIVRVRDLVVEGELLALVMDLI 99 Query: 305 SGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGE 484 GPDL + LR P+ AA + AQ+A ALA H GV+HRD+KP NV+L + Sbjct: 100 DGPDLHRY--LRENGPLTPVAAALLTAQIADALAASHADGVVHRDLKPANVLL----KQT 153 Query: 485 NGSPRARLADFGSAAWIGADG 547 G L DFG A + G Sbjct: 154 GGEMHPMLTDFGIARLADSPG 174
>CBK1_YARLI (Q6CFS5) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 588 Score = 67.8 bits (164), Expect = 2e-11 Identities = 39/156 (25%), Positives = 78/156 (50%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V R G+ +A+K++ + + D+ + A ++ + LA + Sbjct: 206 DFVTVKVIGKGAFGEVRLVQKRDNGKIYAMKTMLKKEM--DMKEQWAHVKAERDVLADSD 263 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V ++ ++DD + +++M+ G DL+ L + E + +A+ A+ Sbjct: 264 SPWIVSLYFSFQDDLYLYLIMEFLPGGDLM--TMLIKYDVFSEDITRFYIAECVLAIEAI 321 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D + +L+DFG Sbjct: 322 HKLGFIHRDIKPDNILID-------KTGHIKLSDFG 350
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 67.8 bits (164), Expect = 2e-11 Identities = 45/150 (30%), Positives = 78/150 (52%), Gaps = 1/150 (0%) Frame = +2 Query: 104 RCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWT 283 RC ++T +AVK +D+S + E+ L +P ++ + VY+D Sbjct: 434 RCVHKATNMEYAVKVIDKSKRDPSEEIEIL--------LRYGQHPNIITLKDVYDDGKHV 485 Query: 284 HMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVL 463 ++V +L G +LLD ++ R E A+ ++ + + + H +GV+HRD+KP N +L Sbjct: 486 YLVTELMRGGELLD--KILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSN-IL 542 Query: 464 DVDDEGENGSPRA-RLADFGSAAWIGADGG 550 VD E+G+P R+ DFG A + A+ G Sbjct: 543 YVD---ESGNPECLRICDFGFAKQLRAENG 569 Score = 59.3 bits (142), Expect = 7e-09 Identities = 42/142 (29%), Positives = 75/142 (52%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + T +G +A+K + ++ L DR ++E + LA +P VV++H ++ + Sbjct: 78 LVRKVTRPDSGHLYAMKVLKKATLKVR-DRVRTKMERDI--LADVNHPFVVKLHYAFQTE 134 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+LA L H G+I+RD+KP+N Sbjct: 135 GKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPEN 192 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++L D+EG +L DFG Sbjct: 193 ILL--DEEG-----HIKLTDFG 207
>KCC2A_MOUSE (P11798) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 67.8 bits (164), Expect = 2e-11 Identities = 42/146 (28%), Positives = 76/146 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC G+ + K ++ L D + E E ++ +L +P +V++H Sbjct: 24 FSVVRRCVKVLAGQEYPAKIINTKKL-SARDHQKLEREARICRLLK--HPNIVRLHDSIS 80 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ +++ DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 81 EEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 138 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N++L +G +LADFG A Sbjct: 139 ENLLLASKLKG----AAVKLADFGLA 160
>CCAMK_LILLO (Q43531) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (LlCCaMK) Length = 520 Score = 67.4 bits (163), Expect = 3e-11 Identities = 32/74 (43%), Positives = 48/74 (64%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P V+ +H VYED + H+V++LCSG +L D R+ E AA++V Q+A LA Sbjct: 101 HPNVIHLHDVYEDANGVHLVLELCSGGELFD--RIVAQDRYSESEAAEVVQQIASGLAAL 158 Query: 413 HRRGVIHRDVKPDN 454 H+ +IHRD+KP+N Sbjct: 159 HKSTIIHRDLKPEN 172
>KPC2_APLCA (Q16975) Calcium-independent protein kinase C (EC 2.7.11.13) (APL| II) Length = 743 Score = 67.4 bits (163), Expect = 3e-11 Identities = 42/144 (29%), Positives = 73/144 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + T E +A+K + + + D D E E ++ L+A +P + +H+ ++ Sbjct: 414 FGKVMLAEKKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILALSAK-HPFLTALHSSFQ 472 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 VM+ +G DL+ +++R EP A A++ AL HR G+I+RD+K Sbjct: 473 TKERLFFVMEYVNGGDLM--FQIQRARKFDEPRARFYAAEVTLALMFLHRHGIIYRDLKL 530 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DN++LD + ++ADFG Sbjct: 531 DNILLDAEG-------HCKIADFG 547
>LATS2_MOUSE (Q7TSJ6) Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large| tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) Length = 1042 Score = 67.0 bits (162), Expect = 3e-11 Identities = 46/145 (31%), Positives = 76/145 (52%), Gaps = 1/145 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDR-ELAEIEPKLAQLAAAGNPGVVQVHAVY 265 FG V T +A+K++ + D L+R ++A ++ + LA A N VV+++ + Sbjct: 637 FGEVCLACKLDTHALYAMKTLRKK---DVLNRNQVAHVKAERDILAEADNEWVVKLYYSF 693 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 +D + VMD G D++ L R PE +A +A+L A+ H+ G IHRD+K Sbjct: 694 QDKDSLYFVMDYIPGGDMMSL--LIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIK 751 Query: 446 PDNVVLDVDDEGENGSPRARLADFG 520 PDN+++D+D +L DFG Sbjct: 752 PDNILIDLDG-------HIKLTDFG 769
>CBK1_CANGA (Q6FP74) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 773 Score = 67.0 bits (162), Expect = 3e-11 Identities = 41/156 (26%), Positives = 77/156 (49%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V + TG+ +A+K++ +S + +LA ++ + LA Sbjct: 369 DFHTVQVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKK--DQLAHVKAERDVLAGTD 426 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V ++ ++D + +++M+ G DL+ L R E V +A+ A+ Sbjct: 427 SPWIVSLYYSFQDAQYLYLIMEFLPGGDLM--TMLIRWQLFTEDVTRFYMAECILAIETI 484 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D+ +L+DFG Sbjct: 485 HKLGFIHRDIKPDNILIDI-------RGHIKLSDFG 513
>KCC2G_MOUSE (Q923T9) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 529 Score = 66.6 bits (161), Expect = 4e-11 Identities = 45/173 (26%), Positives = 84/173 (48%), Gaps = 8/173 (4%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY F VV RC +++ + +A K ++ L D + E E ++ +L Sbjct: 13 DYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL-SARDHQKLEREARICRLLK-- 69 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V++H ++ + ++V DL +G +L + + R E A+ + Q+ +++ Sbjct: 70 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIHQILESVNHI 127 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 H+ ++HRD+KP+N++L +G +LADFG A AW G G Sbjct: 128 HQHDIVHRDLKPENLLLASKCKG----AAVKLADFGLAIEVQGEQQAWFGFAG 176
>KCC2G_HUMAN (Q13555) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 558 Score = 66.6 bits (161), Expect = 4e-11 Identities = 45/173 (26%), Positives = 84/173 (48%), Gaps = 8/173 (4%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY F VV RC +++ + +A K ++ L D + E E ++ +L Sbjct: 13 DYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL-SARDHQKLEREARICRLLK-- 69 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V++H ++ + ++V DL +G +L + + R E A+ + Q+ +++ Sbjct: 70 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIHQILESVNHI 127 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 H+ ++HRD+KP+N++L +G +LADFG A AW G G Sbjct: 128 HQHDIVHRDLKPENLLLASKCKG----AAVKLADFGLAIEVQGEQQAWFGFAG 176
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 66.6 bits (161), Expect = 4e-11 Identities = 40/177 (22%), Positives = 85/177 (48%), Gaps = 8/177 (4%) Frame = +2 Query: 38 GELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSV-----DRSNLPDD---LDRELA 193 G++ Y +G V C ++ A+K + D+ DD +++ Sbjct: 50 GKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYNDDNKNIEKFHE 109 Query: 194 EIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAA 373 EI +++ L + +P ++++ V+ED + ++V + G +L + + R E AA Sbjct: 110 EIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRH--KFDECDAA 167 Query: 374 DIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGAD 544 +I+ Q+ + H+ ++HRD+KP+N++L E +N ++ DFG +++ D Sbjct: 168 NIMKQILSGICYLHKHNIVHRDIKPENILL----ENKNSLLNIKIVDFGLSSFFSKD 220
>KCC2G_RAT (P11730) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 527 Score = 66.6 bits (161), Expect = 4e-11 Identities = 45/173 (26%), Positives = 84/173 (48%), Gaps = 8/173 (4%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY F VV RC +++ + +A K ++ L D + E E ++ +L Sbjct: 13 DYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL-SARDHQKLEREARICRLLK-- 69 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V++H ++ + ++V DL +G +L + + R E A+ + Q+ +++ Sbjct: 70 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIHQILESVNHI 127 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 H+ ++HRD+KP+N++L +G +LADFG A AW G G Sbjct: 128 HQHDIVHRDLKPENLLLASKCKG----AAVKLADFGLAIEVQGEQQAWFGFAG 176
>KPC1_DROME (P05130) Protein kinase C, brain isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(BR)) Length = 679 Score = 66.6 bits (161), Expect = 4e-11 Identities = 43/144 (29%), Positives = 74/144 (51%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + + E +A+K + + + D D E IE ++ L P +VQ+H+ ++ Sbjct: 361 FGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKP-PFLVQLHSCFQ 419 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 VM+ +G DL+ ++++ EPVA A++A L H +G+++RD+K Sbjct: 420 TMDRLFFVMEYVNGGDLM--FQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKL 477 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DNV+LD D ++ADFG Sbjct: 478 DNVLLDADG-------HVKIADFG 494
>PHKG1_HUMAN (Q16816) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 66.6 bits (161), Expect = 4e-11 Identities = 43/148 (29%), Positives = 75/148 (50%), Gaps = 6/148 (4%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVD----RSNLPDDLDRELAEIEPKLAQLA--AAGNPGVVQVH 256 VV RC + T + +AVK +D S P+++ REL E K + +G+P ++Q+ Sbjct: 32 VVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEV-RELREATLKEVDILRKVSGHPNIIQLK 90 Query: 257 AVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHR 436 YE +++ +V DL +L D+ L + E I+ L + + H+ ++HR Sbjct: 91 DTYETNTFFFLVFDLMKRGELFDY--LTEKVTLSEKETRKIMRALLEVICTLHKLNIVHR 148 Query: 437 DVKPDNVVLDVDDEGENGSPRARLADFG 520 D+KP+N++LD + +L DFG Sbjct: 149 DLKPENILLD-------DNMNIKLTDFG 169
>KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC 2.7.11.11) (PKA| 1) (CDC25-suppressing protein kinase) (PK-25) Length = 397 Score = 66.6 bits (161), Expect = 4e-11 Identities = 44/165 (26%), Positives = 80/165 (48%), Gaps = 3/165 (1%) Frame = +2 Query: 50 RDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIE---PKLAQL 220 +D+ FG VH SR G +A+K + + ++ L ++E + L Sbjct: 85 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKK-----EIVVRLKQVEHTNDERLML 139 Query: 221 AAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 + +P ++++ ++D M+MD G +L LR+ P PVA A++ A Sbjct: 140 SIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSL--LRKSQRFPNPVAKFYAAEVCLA 197 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWI 535 L H + +I+RD+KP+N++LD +NG ++ DFG A ++ Sbjct: 198 LEYLHSKDIIYRDLKPENILLD-----KNG--HIKITDFGFAKYV 235
>KSG1_SCHPO (Q12701) Serine/threonine-protein kinase ksg1 (EC 2.7.11.1)| Length = 592 Score = 66.2 bits (160), Expect = 6e-11 Identities = 43/157 (27%), Positives = 77/157 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V T ST +A+K +D+ ++ + + IE K A + +PG +++ ++ Sbjct: 110 YSTVLTATENSTKREYAIKVLDKRHIIKEKKEKYVNIE-KEALCILSKHPGFIKLFYTFQ 168 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + V+ L +LLD++ + E A A + ++ H RGVIHRD+KP Sbjct: 169 DAHNLYFVLSLARNGELLDYIN--KLGRFNEICAQYYAALIVDSIDYMHGRGVIHRDLKP 226 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADGGRAE 559 +N++LD + R ++ DFGSA + + G E Sbjct: 227 ENILLD-------DNMRTKITDFGSAKILNSSHGSHE 256
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 66.2 bits (160), Expect = 6e-11 Identities = 42/144 (29%), Positives = 74/144 (51%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V ++TG+ FAVK + + L + + IE ++A L + +V + +YE Sbjct: 34 FSEVVLAEEKATGKLFAVKCIPKKALKG----KESSIENEIAVLRKIKHENIVALEDIYE 89 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM L SG +L D R+ E A+ ++ Q+ A+ HR G++HRD+KP Sbjct: 90 SPNHLYLVMQLVSGGELFD--RIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKP 147 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++ DE + ++DFG Sbjct: 148 ENLLYYSQDE----ESKIMISDFG 167
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 66.2 bits (160), Expect = 6e-11 Identities = 42/144 (29%), Positives = 74/144 (51%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V ++TG+ FAVK + + L + + IE ++A L + +V + +YE Sbjct: 34 FSEVVLAEEKATGKLFAVKCIPKKALKG----KESSIENEIAVLRKIKHENIVALEDIYE 89 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM L SG +L D R+ E A+ ++ Q+ A+ HR G++HRD+KP Sbjct: 90 SPNHLYLVMQLVSGGELFD--RIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKP 147 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++ DE + ++DFG Sbjct: 148 ENLLYYSQDE----ESKIMISDFG 167
>PKNF_MYCTU (P72003) Probable serine/threonine-protein kinase pknF (EC| 2.7.11.1) Length = 476 Score = 66.2 bits (160), Expect = 6e-11 Identities = 38/110 (34%), Positives = 56/110 (50%) Frame = +2 Query: 221 AAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 A+ +P +V VH E D + MD G D + +R R +P P +I+ +A+A Sbjct: 65 ASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLRDRYPNGMPGPEVTEIITAVAEA 124 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADGG 550 L H R ++HRDVKP N+++ D + R LADFG A W+ G Sbjct: 125 LDYAHERRLLHRDVKPANILIANPDSPDR---RIMLADFGIAGWVDDPSG 171
>PKNF_MYCBO (Q7TZN1) Probable serine/threonine-protein kinase pknF (EC| 2.7.11.1) Length = 476 Score = 66.2 bits (160), Expect = 6e-11 Identities = 38/110 (34%), Positives = 56/110 (50%) Frame = +2 Query: 221 AAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 A+ +P +V VH E D + MD G D + +R R +P P +I+ +A+A Sbjct: 65 ASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLRDRYPNGMPGPEVTEIITAVAEA 124 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADGG 550 L H R ++HRDVKP N+++ D + R LADFG A W+ G Sbjct: 125 LDYAHERRLLHRDVKPANILIANPDSPDR---RIMLADFGIAGWVDDPSG 171
>PHKG2_RAT (P31325) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 66.2 bits (160), Expect = 6e-11 Identities = 45/147 (30%), Positives = 74/147 (50%), Gaps = 5/147 (3%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQ-----LAAAGNPGVVQVHA 259 VV RC R+TG+ FAVK ++ S L+ +L E+ + AG+P ++ + Sbjct: 37 VVRRCVHRATGDEFAVKIMEVSAERLSLE-QLEEVRDATRREMHILRQVAGHPHIITLID 95 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 YE S+ +V DL +L D+ L + E I+ L +A+ H ++HRD Sbjct: 96 SYESSSFMFLVFDLMRKGELFDY--LTEKVALSEKETRSIMRSLLEAVNFLHVNNIVHRD 153 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFG 520 +KP+N++LD + + RL+DFG Sbjct: 154 LKPENILLD-------DNMQIRLSDFG 173
>NEK1_HUMAN (Q96PY6) Serine/threonine-protein kinase Nek1 (EC 2.7.11.1)| (NimA-related protein kinase 1) (NY-REN-55 antigen) Length = 1258 Score = 66.2 bits (160), Expect = 6e-11 Identities = 42/146 (28%), Positives = 66/146 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG S G + +K ++ S + +E E ++A LA +P +VQ +E Sbjct: 15 FGKAILVKSTEDGRQYVIKEINISRMSS---KEREESRREVAVLANMKHPNIVQYRESFE 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ ++VMD C G DL + ++G E D Q+ AL H R ++HRD+K Sbjct: 72 ENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKS 131 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 N+ L D +L DFG A Sbjct: 132 QNIFLTKDG-------TVQLGDFGIA 150
>ORB6_SCHPO (O13310) Serine/threonine-protein kinase orb6 (EC 2.7.11.1)| Length = 469 Score = 66.2 bits (160), Expect = 6e-11 Identities = 43/156 (27%), Positives = 76/156 (48%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V TG+ +A+KS+ ++ + +LA ++ + L + Sbjct: 92 DFSTIKVIGKGAFGEVRLVQKLDTGKIYAMKSLLKTEMFKR--DQLAHVKAERDLLVESD 149 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VV ++ ++D + +++M+ G DL+ L E V +A+ A+A Sbjct: 150 SPWVVSLYYAFQDSLYLYLIMEFLPGGDLM--TMLINYDTFSEDVTRFYMAECVLAIADV 207 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 HR G IHRD+KPDN+++D D +L+DFG Sbjct: 208 HRMGYIHRDIKPDNILIDRDG-------HIKLSDFG 236
>PASK_MOUSE (Q8CEE6) PAS domain-containing serine/threonine-protein kinase (EC| 2.7.11.1) (PAS-kinase) (PASKIN) Length = 1383 Score = 66.2 bits (160), Expect = 6e-11 Identities = 45/170 (26%), Positives = 82/170 (48%), Gaps = 4/170 (2%) Frame = +2 Query: 38 GELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDL---DRELAEIEPK 208 GE + Y FG V + + VK + + + +D D +L + + Sbjct: 1053 GEYDYKYNTISPLGSGAFGFVWTAVEKECNKEVVVKFIKKEKVLEDCWIEDPKLGRVTLE 1112 Query: 209 LAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLC-SGPDLLDWVRLRRGAPVPEPVAADIVA 385 +A L+ + +++V ++E+ + +VM+ SG DL ++ + EP+A+ I Sbjct: 1113 IAILSKVDHANIIKVLDIFENQEFFQLVMEKHGSGMDLFAFID--HHPCLDEPLASFIFR 1170 Query: 386 QLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWI 535 QL A+ H +G+IHRD+K +N+V+ D +L DFGSAA++ Sbjct: 1171 QLVSAVGYLHSQGIIHRDIKDENIVIAEDF-------TIKLIDFGSAAYL 1213
>KPC1B_CAEEL (P34885) Protein kinase C-like 1B (EC 2.7.11.13) (PKC1B)| Length = 707 Score = 65.9 bits (159), Expect = 8e-11 Identities = 45/156 (28%), Positives = 73/156 (46%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V + T E +A+K + + + D D E E ++ LAA Sbjct: 377 DFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAK- 435 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P + +H+ ++ VM+ +G DL+ +++R E A A++ AL Sbjct: 436 HPFLTALHSSFQTSDRLFFVMEYVNGGDLM--FQIQRARKFDESRARFYAAEVTCALQFL 493 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 HR VI+RD+K DN++LD + RLADFG Sbjct: 494 HRNDVIYRDLKLDNILLDAEG-------HCRLADFG 522
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 65.9 bits (159), Expect = 8e-11 Identities = 49/169 (28%), Positives = 79/169 (46%) Frame = +2 Query: 20 NH*TMSGELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEI 199 N + S L Y F VV C RSTG+ FA+K +D++ +E I Sbjct: 382 NRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKC---CGKEHL-I 437 Query: 200 EPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADI 379 E +++ L +P ++ + E + +VM+L G DL D + E + + Sbjct: 438 ENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFD--AITSSTKYTERDGSAM 495 Query: 380 VAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 V LA AL H ++HRD+KP+N+++ E +G+ +L DFG A Sbjct: 496 VYNLANALRYLHGLSIVHRDIKPENLLV---CEYPDGTKSLKLGDFGLA 541
>WIN1_SCHPO (O74304) MAP kinase kinase kinase win1 (EC 2.7.11.25)| Length = 1436 Score = 65.9 bits (159), Expect = 8e-11 Identities = 49/151 (32%), Positives = 72/151 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V+R + TG+ AVK V + P + I+ ++ L +P VV + + Sbjct: 1131 FGTVYRAVNLDTGDLMAVKEV-ALHKPRISRPMIKRIKGEMLVLELFDHPNVVSYYGIEV 1189 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ M+LC G L ++ LR G E V V QL + LA H GV H+DVKP Sbjct: 1190 HREKVNIFMELCQGSSLFEF--LRYGRIEDELVIQVYVLQLLEGLAYIHSCGVSHQDVKP 1247 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +N++ D NG + DFGSA G+ Sbjct: 1248 ENILFD-----HNGI--MKFTDFGSAKMSGS 1271
>MYLK_DICDI (P25323) Myosin light chain kinase (EC 2.7.11.18) (MLCK)| Length = 295 Score = 65.9 bits (159), Expect = 8e-11 Identities = 39/166 (23%), Positives = 87/166 (52%) Frame = +2 Query: 41 ELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQL 220 E+ + Y F +V+ ++ T + +A+K +++S L D ++ L + ++ L Sbjct: 3 EVEKIYEFKEELGRGAFSIVYLGENKQTKQRYAIKVINKSELGKDYEKNL---KMEVDIL 59 Query: 221 AAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 +P ++ + +++ ++VM+L +G +L D + + +G+ E AA++V ++ A Sbjct: 60 KKVNHPNIIALKELFDTPEKLYLVMELVTGGELFDKI-VEKGS-YSEADAANLVKKIVSA 117 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIG 538 + H ++HRD+KP+N++L + + +ADFG + IG Sbjct: 118 VGYLHGLNIVHRDLKPENLLL----KSKENHLEVAIADFGLSKIIG 159
>COT1_NEUCR (P38679) Serine/threonine-protein kinase cot-1 (EC 2.7.11.1)| (Colonial temperature-sensitive 1) Length = 598 Score = 65.9 bits (159), Expect = 8e-11 Identities = 40/144 (27%), Positives = 76/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V ++ G+ +A+KS+ ++ + +LA + + LA + +P VV+++ ++ Sbjct: 225 FGEVKLVQKKADGKVYAMKSLIKTEMFKK--DQLAHVRAERDILAESDSPWVVKLYTTFQ 282 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D ++ +M+M+ G DL+ L + E + +A++ A+ H+ G IHRD+KP Sbjct: 283 DANFLYMLMEFLPGGDLM--TMLIKYEIFSEDITRFYIAEIVLAIDAVHKLGFIHRDIKP 340 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DN++LD +L DFG Sbjct: 341 DNILLD-------RGGHVKLTDFG 357
>CCAMK_MEDTR (Q6RET7) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase DMI-3 (EC 2.7.11.17) (Does not make infections protein 3) (CCaMK DMI3) (MtCCaMK) Length = 523 Score = 65.9 bits (159), Expect = 8e-11 Identities = 38/97 (39%), Positives = 57/97 (58%), Gaps = 1/97 (1%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P V+ ++ VYED + H+V++LCSG +L D R+ E AA +V Q+A L Sbjct: 105 HPNVIDLYDVYEDTNGVHLVLELCSGGELFD--RIVAQDKYSETEAATVVHQIASGLEAV 162 Query: 413 HRRGVIHRDVKPDN-VVLDVDDEGENGSPRARLADFG 520 HR ++HRD+KP+N + LDV SP ++ DFG Sbjct: 163 HRANIVHRDLKPENCLFLDV----RKDSP-LKIMDFG 194
>KCC4_HUMAN (Q16566) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 473 Score = 65.1 bits (157), Expect = 1e-10 Identities = 39/144 (27%), Positives = 79/144 (54%), Gaps = 2/144 (1%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V+RC + T + +A+K + ++ +D+++ E + L +P ++++ ++E Sbjct: 59 IVYRCKQKGTQKPYALKVLKKT-----VDKKIVRTE--IGVLLRLSHPNIIKLKEIFETP 111 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 + +V++L +G +L D R+ E AAD V Q+ +A+A H G++HRD+KP+N Sbjct: 112 TEISLVLELVTGGELFD--RIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPEN 169 Query: 455 VVLDVDDEGENGSPRA--RLADFG 520 ++ +P A ++ADFG Sbjct: 170 LLY------ATPAPDAPLKIADFG 187
>KCC4_RAT (P13234) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) (Calspermin) Length = 474 Score = 65.1 bits (157), Expect = 1e-10 Identities = 39/144 (27%), Positives = 79/144 (54%), Gaps = 2/144 (1%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V+RC + T + +A+K + ++ +D+++ E + L +P ++++ ++E Sbjct: 55 IVYRCKQKGTQKPYALKVLKKT-----VDKKIVRTE--IGVLLRLSHPNIIKLKEIFETP 107 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 + +V++L +G +L D R+ E AAD V Q+ +A+A H G++HRD+KP+N Sbjct: 108 TEISLVLELVTGGELFD--RIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPEN 165 Query: 455 VVLDVDDEGENGSPRA--RLADFG 520 ++ +P A ++ADFG Sbjct: 166 LLY------ATPAPDAPLKIADFG 183
>LATS2_HUMAN (Q9NRM7) Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large| tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase) Length = 1088 Score = 65.1 bits (157), Expect = 1e-10 Identities = 45/145 (31%), Positives = 75/145 (51%), Gaps = 1/145 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDR-ELAEIEPKLAQLAAAGNPGVVQVHAVY 265 FG V T +A+K++ + D L+R ++ ++ + LA A N VV+++ + Sbjct: 679 FGEVCLACKVDTHALYAMKTLRKK---DVLNRNQVVHVKAERDILAEADNEWVVKLYYSF 735 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 +D + VMD G D++ L R PE +A +A+L A+ H+ G IHRD+K Sbjct: 736 QDKDSLYFVMDYIPGGDMMSL--LIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIK 793 Query: 446 PDNVVLDVDDEGENGSPRARLADFG 520 PDN+++D+D +L DFG Sbjct: 794 PDNILIDLDG-------HIKLTDFG 811
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 64.7 bits (156), Expect = 2e-10 Identities = 50/167 (29%), Positives = 82/167 (49%), Gaps = 1/167 (0%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY VVH+C ++T +AVK V ++ D E+ + L + Sbjct: 453 DYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVF--DATEEVDIL------LRHSH 504 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 + VV++ VYED++ +M+ +LC G +LLD + ++ + VAA I+A L A+ Sbjct: 505 HQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAA-IMANLLNAVQYL 563 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 H + V HRD+ N++ + D G P + R+ DFG A A+ G Sbjct: 564 HSQQVAHRDLTAANILFALKD----GDPSSLRIVDFGFAKQSRAENG 606 Score = 62.0 bits (149), Expect = 1e-09 Identities = 38/142 (26%), Positives = 74/142 (52%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + R +G +A+K + ++ L DR+ ++E + LA +P +V++H ++ + Sbjct: 120 LVRKVRGRDSGHVYAMKVLKKATLKVR-DRQRTKLERNI--LAHISHPFIVKLHYAFQTE 176 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+L AL H G+++RD+KP+N Sbjct: 177 GKLYLILDFLRGGDL--FTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPEN 234 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++LD D ++ DFG Sbjct: 235 ILLDADG-------HIKVTDFG 249
>LATS1_HUMAN (O95835) Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large| tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) Length = 1130 Score = 64.7 bits (156), Expect = 2e-10 Identities = 44/144 (30%), Positives = 75/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V T +A K++ + ++ L ++A ++ + LA A N VV+++ ++ Sbjct: 716 FGEVCLARKVDTKALYATKTLRKKDVL--LRNQVAHVKAERDILAEADNEWVVRLYYSFQ 773 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + VMD G D++ + +R G PE +A +A+L A+ H+ G IHRD+KP Sbjct: 774 DKDNLYFVMDYIPGGDMMSLL-IRMGI-FPESLARFYIAELTCAVESVHKMGFIHRDIKP 831 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DN+++D D +L DFG Sbjct: 832 DNILIDRDG-------HIKLTDFG 848
>KPCA_RAT (P05696) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 64.7 bits (156), Expect = 2e-10 Identities = 49/174 (28%), Positives = 83/174 (47%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDL 178 P E+ S L+R D+ FG V + T E +A+K + + + D Sbjct: 319 PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 378 Query: 179 DRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 D E +E ++ L P + Q+H+ ++ + VM+ +G DL+ +++ Sbjct: 379 DVECTMVEKRVLALLDKP-PFLTQLHSCFQTVDRLYFVMEYVNGGDLM--YHIQQVGKFK 435 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP A A+++ L H+RG+I+RD+K DNV+L D EG ++ADFG Sbjct: 436 EPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVML--DSEG-----HIKIADFG 482
>KPCA_RABIT (P10102) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 64.7 bits (156), Expect = 2e-10 Identities = 49/174 (28%), Positives = 83/174 (47%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDL 178 P E+ S L+R D+ FG V + T E +A+K + + + D Sbjct: 319 PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 378 Query: 179 DRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 D E +E ++ L P + Q+H+ ++ + VM+ +G DL+ +++ Sbjct: 379 DVECTMVEKRVLALMDKP-PFLTQLHSCFQTVDRLYFVMEYVNGGDLM--YHIQQVGKFK 435 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP A A+++ L H+RG+I+RD+K DNV+L D EG ++ADFG Sbjct: 436 EPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVML--DSEG-----HIKIADFG 482
>KPCA_HUMAN (P17252) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 64.7 bits (156), Expect = 2e-10 Identities = 49/174 (28%), Positives = 83/174 (47%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDL 178 P E+ S L+R D+ FG V + T E +A+K + + + D Sbjct: 319 PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 378 Query: 179 DRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 D E +E ++ L P + Q+H+ ++ + VM+ +G DL+ +++ Sbjct: 379 DVECTMVEKRVLALLDKP-PFLTQLHSCFQTVDRLYFVMEYVNGGDLM--YHIQQVGKFK 435 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP A A+++ L H+RG+I+RD+K DNV+L D EG ++ADFG Sbjct: 436 EPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVML--DSEG-----HIKIADFG 482
>KPCA_BOVIN (P04409) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 64.7 bits (156), Expect = 2e-10 Identities = 49/174 (28%), Positives = 83/174 (47%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDL 178 P E+ S L+R D+ FG V + T E +A+K + + + D Sbjct: 319 PSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 378 Query: 179 DRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 D E +E ++ L P + Q+H+ ++ + VM+ +G DL+ +++ Sbjct: 379 DVECTMVEKRVLALLDKP-PFLTQLHSCFQTVDRLYFVMEYVNGGDLM--YHIQQVGKFK 435 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP A A+++ L H+RG+I+RD+K DNV+L D EG ++ADFG Sbjct: 436 EPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVML--DSEG-----HIKIADFG 482
>SNRK_MOUSE (Q8VDU5) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 748 Score = 64.3 bits (155), Expect = 2e-10 Identities = 40/144 (27%), Positives = 76/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV TGE AVK +D++ L L + ++ + +P +V+++ V + Sbjct: 27 FAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQ---EVRCMKLVQHPNIVRLYEVID 83 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + +++++L G D+ D++ ++ + E +A AQ+ A++ CH+ V+HRD+KP Sbjct: 84 TQTKLYLILELGDGGDMFDYI-MKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NVV + +G +L DFG Sbjct: 143 ENVVF-FEKQG-----LVKLTDFG 160
>CBK1_PNECA (Q6TGC6) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 507 Score = 64.3 bits (155), Expect = 2e-10 Identities = 41/156 (26%), Positives = 77/156 (49%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V TG+ +A+K++ +S + +LA ++ + LA + Sbjct: 125 DFHTVKVIGKGAFGEVRLVQKIDTGKIYAMKTLLKSEMFKK--DQLAHVKAERDVLAESD 182 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VV ++ ++D + +++M+ G DL+ L + E V +A+ A+ Sbjct: 183 SPWVVSLYYSFQDSQYLYLIMEFLPGGDLM--TMLIKYDTFSEDVTRFYIAECILAIEAV 240 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D + +L+DFG Sbjct: 241 HKLGFIHRDIKPDNILID-------KTGHIKLSDFG 269
>KPCZ_RAT (P09217) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 592 Score = 64.3 bits (155), Expect = 2e-10 Identities = 40/135 (29%), Positives = 73/135 (54%) Frame = +2 Query: 116 RSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVM 295 + + +A+K V + + DD D + + E + + A++ NP +V +H+ ++ S +V+ Sbjct: 272 KKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS-NPFLVGLHSCFQTTSRLFLVI 330 Query: 296 DLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDD 475 + +G DL+ ++R +PE A A++ AL H RG+I+RD+K DNV+LD D Sbjct: 331 EYVNGGDLM--FHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADG 388 Query: 476 EGENGSPRARLADFG 520 +L D+G Sbjct: 389 -------HIKLTDYG 396
>KPCZ_MOUSE (Q02956) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 592 Score = 64.3 bits (155), Expect = 2e-10 Identities = 40/135 (29%), Positives = 73/135 (54%) Frame = +2 Query: 116 RSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVM 295 + + +A+K V + + DD D + + E + + A++ NP +V +H+ ++ S +V+ Sbjct: 272 KKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS-NPFLVGLHSCFQTTSRLFLVI 330 Query: 296 DLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDD 475 + +G DL+ ++R +PE A A++ AL H RG+I+RD+K DNV+LD D Sbjct: 331 EYVNGGDLM--FHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADG 388 Query: 476 EGENGSPRARLADFG 520 +L D+G Sbjct: 389 -------HIKLTDYG 396
>KPCZ_HUMAN (Q05513) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 592 Score = 64.3 bits (155), Expect = 2e-10 Identities = 40/135 (29%), Positives = 73/135 (54%) Frame = +2 Query: 116 RSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVM 295 + + +A+K V + + DD D + + E + + A++ NP +V +H+ ++ S +V+ Sbjct: 272 KKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS-NPFLVGLHSCFQTTSRLFLVI 330 Query: 296 DLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDD 475 + +G DL+ ++R +PE A A++ AL H RG+I+RD+K DNV+LD D Sbjct: 331 EYVNGGDLM--FHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADG 388 Query: 476 EGENGSPRARLADFG 520 +L D+G Sbjct: 389 -------HIKLTDYG 396
>KPCG_BOVIN (P05128) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| (Fragment) Length = 682 Score = 64.3 bits (155), Expect = 2e-10 Identities = 42/160 (26%), Positives = 75/160 (46%), Gaps = 4/160 (2%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V R + E +A+K + + + D D + +E ++ L G Sbjct: 335 DFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRG 394 Query: 233 NPG----VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 G + Q+H+ ++ + VM+ +G DL+ +++ EP AA A++A Sbjct: 395 PGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLM--YHIQQLGKFKEPHAAFYAAEIAIG 452 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H +G+I+RD+K DNV+LD + ++ DFG Sbjct: 453 LFFLHNQGIIYRDLKLDNVMLDAEG-------HIKITDFG 485
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 64.3 bits (155), Expect = 2e-10 Identities = 43/148 (29%), Positives = 78/148 (52%), Gaps = 1/148 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAE-IEPKLAQLAAAGNPGVVQVHAVY 265 F V R TG++ AVK +++ L + LA I+ +++ + +P +V++H V Sbjct: 32 FAKVFHARDRRTGQSVAVKILNKKKLLTN--PALANNIKREISIMRRLSHPNIVKLHEVM 89 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 S M+ G +L + ++ + + E ++ QL A+ CH RGV HRD+K Sbjct: 90 ATKSKIFFAMEFVKGGELFN--KISKHGRLSEDLSRRYFQQLISAVGYCHARGVYHRDLK 147 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSAA 529 P+N+++D ENG+ +++DFG +A Sbjct: 148 PENLLID-----ENGN--LKVSDFGLSA 168
>SNRK_HUMAN (Q9NRH2) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 765 Score = 64.3 bits (155), Expect = 2e-10 Identities = 40/144 (27%), Positives = 76/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV TGE AVK +D++ L L + ++ + +P +V+++ V + Sbjct: 27 FAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQ---EVRCMKLVQHPNIVRLYEVID 83 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + +++++L G D+ D++ ++ + E +A AQ+ A++ CH+ V+HRD+KP Sbjct: 84 TQTKLYLILELGDGGDMFDYI-MKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NVV + +G +L DFG Sbjct: 143 ENVVF-FEKQG-----LVKLTDFG 160
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 64.3 bits (155), Expect = 2e-10 Identities = 39/158 (24%), Positives = 81/158 (51%) Frame = +2 Query: 47 NRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAA 226 N Y FG V + TG +A+K + + ++ D++ E +L ++ Sbjct: 66 NEQYKGIKILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLD 125 Query: 227 AGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALA 406 N +++++ +ED+++ ++V D+ SG +L D + R+ E AA I+ Q+ + Sbjct: 126 HIN--IMKLYEFFEDNNYYYLVSDVYSGGELFDEIISRKR--FYEVDAARIIKQVLSGIT 181 Query: 407 LCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ V+HRD+KP+N++L+ ++ + ++ DFG Sbjct: 182 YMHKNNVVHRDLKPENILLETKNKED---MIIKIIDFG 216
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 64.3 bits (155), Expect = 2e-10 Identities = 39/158 (24%), Positives = 81/158 (51%) Frame = +2 Query: 47 NRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAA 226 N Y FG V + TG +A+K + + ++ D+E E +L ++ Sbjct: 66 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD 125 Query: 227 AGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALA 406 N +++++ +ED+++ ++V D+ +G +L D + R+ E AA I+ Q+ + Sbjct: 126 HIN--IMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKR--FYEIDAARIIKQILSGIT 181 Query: 407 LCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ V+HRD+KP+N++L+ ++ + ++ DFG Sbjct: 182 YMHKNNVVHRDLKPENILLETKNKED---MIIKIIDFG 216
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 64.3 bits (155), Expect = 2e-10 Identities = 39/158 (24%), Positives = 81/158 (51%) Frame = +2 Query: 47 NRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAA 226 N Y FG V + TG +A+K + + ++ D++ E +L ++ Sbjct: 66 NEQYKGIKILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLD 125 Query: 227 AGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALA 406 N +++++ +ED+++ ++V D+ SG +L D + R+ E AA I+ Q+ + Sbjct: 126 HIN--IMKLYEFFEDNNYYYLVSDVYSGGELFDEIISRKR--FYEVDAARIIKQVLSGIT 181 Query: 407 LCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ V+HRD+KP+N++L+ ++ + ++ DFG Sbjct: 182 YMHKNNVVHRDLKPENILLETKNKED---MIIKIIDFG 216
>SNRK_RAT (Q63553) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 746 Score = 64.3 bits (155), Expect = 2e-10 Identities = 40/144 (27%), Positives = 76/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV TGE AVK +D++ L L + ++ + +P +V+++ V + Sbjct: 27 FAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQ---EVRCMKLVQHPNIVRLYEVID 83 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + +++++L G D+ D++ ++ + E +A AQ+ A++ CH+ V+HRD+KP Sbjct: 84 TQTKLYLILELGDGGDMFDYI-MKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NVV + +G +L DFG Sbjct: 143 ENVVF-FEKQG-----LVKLTDFG 160
>LATS1_MOUSE (Q8BYR2) Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large| tumor suppressor homolog 1) (WARTS protein kinase) Length = 1129 Score = 64.3 bits (155), Expect = 2e-10 Identities = 44/144 (30%), Positives = 75/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V T +A K++ + ++ L ++A ++ + LA A N VV+++ ++ Sbjct: 715 FGEVCLARKVDTKALYATKTLRKKDVL--LRNQVAHVKAERDILAEADNEWVVRLYYSFQ 772 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + VMD G D++ + +R G PE +A +A+L A+ H+ G IHRD+KP Sbjct: 773 DKDNLYFVMDYIPGGDMMSLL-IRMGI-FPENLARFYIAELTCAVESVHKMGFIHRDIKP 830 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DN+++D D +L DFG Sbjct: 831 DNILIDRDG-------HIKLTDFG 847
>KOIA_SCHPO (Q9Y7J6) Putative serine/threonine-protein kinase C1778.10c (EC| 2.7.11.1) Length = 550 Score = 64.3 bits (155), Expect = 2e-10 Identities = 38/158 (24%), Positives = 77/158 (48%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY F V R T + + + +A+K +D+ + + + IE + + + G Sbjct: 53 DYVFGDIIGDGSFSKVRRATDKKSWKEYAIKVLDKKYIVKENKVKYVNIE-RDSMMRLNG 111 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 PG+ ++ ++DD + V++L +LL +++ R + E A++ ++ Sbjct: 112 FPGISRLFHTFQDDLKLYYVLELAPNGELLQYIKKYRF--LDENCVRFYAAEILSSIEYM 169 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 H G+IHRD+KP+N++ D G+ ++ DFG+A Sbjct: 170 HSCGIIHRDLKPENILFD-------GNMHVKITDFGTA 200
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 64.3 bits (155), Expect = 2e-10 Identities = 39/144 (27%), Positives = 75/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V+ + TG A+K++ +S L + E ++ N +++++ + Sbjct: 100 FGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKN--ILRLYGHFH 157 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ +++++ +L + LRR E VA+ + Q+A AL+ H++ VIHRD+KP Sbjct: 158 DEKRIYLILEFAGRGEL--YQHLRRAKRFSEEVASKYIFQMANALSYLHKKHVIHRDIKP 215 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++L +D E +L+DFG Sbjct: 216 ENILLGIDGE-------IKLSDFG 232
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 64.3 bits (155), Expect = 2e-10 Identities = 45/144 (31%), Positives = 75/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + TG AVK ++R + LD + +I+ ++ L +P +++++ V Sbjct: 27 FGKVKIGEHQLTGHKVAVKILNRQKIRS-LD-VVGKIKREIQNLKLFRHPHIIKLYQVIS 84 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + MVM+ SG +L D++ + V E A + Q+ A+ CHR V+HRD+KP Sbjct: 85 TPTDFFMVMEYVSGGELFDYIC--KHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 143 ENVLLD-------AQMNAKIADFG 159
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 64.3 bits (155), Expect = 2e-10 Identities = 45/144 (31%), Positives = 75/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + TG AVK ++R + LD + +I+ ++ L +P +++++ V Sbjct: 27 FGKVKIGEHQLTGHKVAVKILNRQKIRS-LD-VVGKIKREIQNLKLFRHPHIIKLYQVIS 84 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + MVM+ SG +L D++ + V E A + Q+ A+ CHR V+HRD+KP Sbjct: 85 TPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 143 ENVLLD-------AQMNAKIADFG 159
>KPCG_RAT (P63319) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 64.3 bits (155), Expect = 2e-10 Identities = 42/160 (26%), Positives = 75/160 (46%), Gaps = 4/160 (2%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V R + E +A+K + + + D D + +E ++ L G Sbjct: 350 DFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRG 409 Query: 233 NPG----VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 G + Q+H+ ++ + VM+ +G DL+ +++ EP AA A++A Sbjct: 410 PGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLM--YHIQQLGKFKEPHAAFYAAEIAIG 467 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H +G+I+RD+K DNV+LD + ++ DFG Sbjct: 468 LFFLHNQGIIYRDLKLDNVMLDAEG-------HIKITDFG 500
>KPCG_RABIT (P10829) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| (PKC-delta) Length = 697 Score = 64.3 bits (155), Expect = 2e-10 Identities = 42/160 (26%), Positives = 75/160 (46%), Gaps = 4/160 (2%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V R + E +A+K + + + D D + +E ++ L G Sbjct: 350 DFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRG 409 Query: 233 NPG----VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 G + Q+H+ ++ + VM+ +G DL+ +++ EP AA A++A Sbjct: 410 PGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLM--YHIQQLGKFKEPHAAFYAAEIAIG 467 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H +G+I+RD+K DNV+LD + ++ DFG Sbjct: 468 LFFLHNQGIIYRDLKLDNVMLDAEG-------HIKITDFG 500
>KPCG_MOUSE (P63318) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 64.3 bits (155), Expect = 2e-10 Identities = 42/160 (26%), Positives = 75/160 (46%), Gaps = 4/160 (2%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V R + E +A+K + + + D D + +E ++ L G Sbjct: 350 DFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRG 409 Query: 233 NPG----VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 G + Q+H+ ++ + VM+ +G DL+ +++ EP AA A++A Sbjct: 410 PGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLM--YHIQQLGKFKEPHAAFYAAEIAIG 467 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H +G+I+RD+K DNV+LD + ++ DFG Sbjct: 468 LFFLHNQGIIYRDLKLDNVMLDAEG-------HIKITDFG 500
>KPCG_HUMAN (P05129) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 64.3 bits (155), Expect = 2e-10 Identities = 42/160 (26%), Positives = 75/160 (46%), Gaps = 4/160 (2%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG V R + E +A+K + + + D D + +E ++ L G Sbjct: 350 DFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRG 409 Query: 233 NPG----VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 G + Q+H+ ++ + VM+ +G DL+ +++ EP AA A++A Sbjct: 410 PGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLM--YHIQQLGKFKEPHAAFYAAEIAIG 467 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H +G+I+RD+K DNV+LD + ++ DFG Sbjct: 468 LFFLHNQGIIYRDLKLDNVMLDAEG-------HIKITDFG 500
>ZYG1_CAEBR (Q621J7) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 709 Score = 64.3 bits (155), Expect = 2e-10 Identities = 40/153 (26%), Positives = 73/153 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FGVV+ R GE A+K + + I+ ++ + + +VQ + + Sbjct: 24 FGVVYSA-QRENGEKVAIKKIGNA-------ASQTRIKEEIKTMKLLRHRNIVQFYETFF 75 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ T++VM+LC G L+D+V+ + P+ + A I+ QL A+ H ++HRD+ Sbjct: 76 ENGETYLVMELCEGGSLMDYVKQK--GPLDDSTAVHILRQLIAAVKYIHDENILHRDLSA 133 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 NV + + + +L DFG A +G G Sbjct: 134 GNVFI---KDATKSTITVKLGDFGLATNLGQHG 163
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 63.9 bits (154), Expect = 3e-10 Identities = 45/144 (31%), Positives = 75/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + TG AVK ++R + LD + +I+ ++ L +P +++++ V Sbjct: 27 FGKVKIGEHQLTGHKVAVKILNRQKIRS-LD-VVGKIKREIQNLKLFRHPHIIKLYQVIS 84 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + MVM+ SG +L D++ + V E A + Q+ A+ CHR V+HRD+KP Sbjct: 85 TPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 143 ENVLLD-------AHMNAKIADFG 159
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 63.9 bits (154), Expect = 3e-10 Identities = 45/144 (31%), Positives = 75/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + TG AVK ++R + LD + +I+ ++ L +P +++++ V Sbjct: 27 FGKVKIGEHQLTGHKVAVKILNRQKIRS-LD-VVGKIKREIQNLKLFRHPHIIKLYQVIS 84 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + MVM+ SG +L D++ + V E A + Q+ A+ CHR V+HRD+KP Sbjct: 85 TPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 143 ENVLLD-------AHMNAKIADFG 159
>ULK2_HUMAN (Q8IYT8) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) Length = 1036 Score = 63.9 bits (154), Expect = 3e-10 Identities = 43/164 (26%), Positives = 81/164 (49%), Gaps = 3/164 (1%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRS-TGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAA 229 +Y F VV R R T A+KS+++ NL + + ++ L Sbjct: 8 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNL----SKSQILLGKEIKILKEL 63 Query: 230 GNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALAL 409 + +V ++ V E + +VM+ C+G DL D+++ + + E + Q+A A+ + Sbjct: 64 QHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAK--GTLSEDTIRVFLHQIAAAMRI 121 Query: 410 CHRRGVIHRDVKPDNVVLDVDDEGEN--GSPRARLADFGSAAWI 535 H +G+IHRD+KP N++L + ++ R ++ADFG A ++ Sbjct: 122 LHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYL 165
>PASK_HUMAN (Q96RG2) PAS domain-containing serine/threonine-protein kinase (EC| 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK) Length = 1323 Score = 63.9 bits (154), Expect = 3e-10 Identities = 44/170 (25%), Positives = 83/170 (48%), Gaps = 4/170 (2%) Frame = +2 Query: 38 GELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDL---DRELAEIEPK 208 GE ++ Y FG V + + VK + + + +D D +L ++ + Sbjct: 993 GEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLE 1052 Query: 209 LAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLC-SGPDLLDWVRLRRGAPVPEPVAADIVA 385 +A L+ + +++V ++E+ + +VM+ SG DL ++ R + EP+A+ I Sbjct: 1053 IAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFID--RHPRLDEPLASYIFR 1110 Query: 386 QLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWI 535 QL A+ + +IHRD+K +N+V+ D +L DFGSAA++ Sbjct: 1111 QLVSAVGYLRLKDIIHRDIKDENIVIAEDF-------TIKLIDFGSAAYL 1153
>ST17B_MOUSE (Q8BG48) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 372 Score = 63.9 bits (154), Expect = 3e-10 Identities = 42/152 (27%), Positives = 78/152 (51%), Gaps = 2/152 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGN-PGVVQVHAVY 265 F VV +C S+STG+ +A KS+ + D AEI ++A L A + P V+ +H VY Sbjct: 44 FAVVRQCISKSTGQEYAAKSLKKRRRGQDCR---AEILHEIAVLELARSCPHVINLHEVY 100 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E+ + +V++ +G ++ + V E ++ Q+ + + H+ ++H D+K Sbjct: 101 ENATEIILVLEYAAGGEIFNLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLK 160 Query: 446 PDNVVL-DVDDEGENGSPRARLADFGSAAWIG 538 P N++L + G+ ++ DFG + IG Sbjct: 161 PQNILLSSIYPLGD-----IKIVDFGMSRKIG 187
>KCC1G_RAT (Q7TNJ7) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 63.9 bits (154), Expect = 3e-10 Identities = 42/144 (29%), Positives = 74/144 (51%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V R TG+ FA+K + +S D + +E ++A L + +V + +YE Sbjct: 34 FSEVFLVKQRVTGKLFALKCIKKSPAFRD-----SSLENEIAVLKRIKHENIVTLEDIYE 88 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM L SG +L D + L RG E A+ ++ Q+ A+ H G++HRD+KP Sbjct: 89 STTHYYLVMQLVSGGELFDRI-LERGV-YTEKDASLVIQQVLSAVKYLHENGIVHRDLKP 146 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++ +E + + + DFG Sbjct: 147 ENLLYLTPEE----NSKIMITDFG 166
>KCC1G_HUMAN (Q96NX5) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 63.9 bits (154), Expect = 3e-10 Identities = 42/144 (29%), Positives = 74/144 (51%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V R TG+ FA+K + +S D + +E ++A L + +V + +YE Sbjct: 34 FSEVFLVKQRLTGKLFALKCIKKSPAFRD-----SSLENEIAVLKKIKHENIVTLEDIYE 88 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM L SG +L D + L RG E A+ ++ Q+ A+ H G++HRD+KP Sbjct: 89 STTHYYLVMQLVSGGELFDRI-LERGV-YTEKDASLVIQQVLSAVKYLHENGIVHRDLKP 146 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++ +E + + + DFG Sbjct: 147 ENLLYLTPEE----NSKIMITDFG 166
>DAPK1_MOUSE (Q80YE7) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1442 Score = 63.9 bits (154), Expect = 3e-10 Identities = 40/149 (26%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDD---LDRELAEIEPKLAQLAAAGNPGVVQVHA 259 F VV +C +STG +A K + + + RE +IE +++ L +P V+ +H Sbjct: 24 FAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRE--DIEREVSILKEIRHPNVITLHE 81 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 VYE+ + ++++L +G +L D++ + + E A + + Q+ + H + H D Sbjct: 82 VYENKTDVILILELVAGGELFDFLAEKES--LTEEEATEFLKQILSGVYYLHSLQIAHFD 139 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFGSA 526 +KP+N++L + PR ++ DFG A Sbjct: 140 LKPENIML---LDRNVPKPRIKIIDFGLA 165
>ATG1_CANAL (Q5A649) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 834 Score = 63.9 bits (154), Expect = 3e-10 Identities = 50/181 (27%), Positives = 81/181 (44%), Gaps = 32/181 (17%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V++C + +A A+KSV RS L E EIE ++ L + +P +V + + Sbjct: 69 FATVYKCIDTTNNKAVAIKSVYRSKLKSKKLLENLEIEIQI--LKSMKHPHIVGLLDYKQ 126 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADI---------------------VA 385 S+ H+VMD CS DL ++R R PV + + + Sbjct: 127 TTSYFHLVMDYCSMGDLSYFIRRRNNLVKSHPVISSLLHRYPSPEGSHGLNEVLVLHFLR 186 Query: 386 QLAQALALCHRRGVIHRDVKPDNVVL-----------DVDDEGENGSPRARLADFGSAAW 532 QL+ AL + ++HRD+KP N++L D + G P ++ADFG A + Sbjct: 187 QLSSALQFLRDKSLVHRDIKPQNLLLCPPVHSKQEFIDGEFVGMWELPILKIADFGFARF 246 Query: 533 I 535 + Sbjct: 247 L 247
>M3K14_MOUSE (Q9WUL6) Mitogen-activated protein kinase kinase kinase 14 (EC| 2.7.11.25) (NF-kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) Length = 942 Score = 63.9 bits (154), Expect = 3e-10 Identities = 47/153 (30%), Positives = 69/153 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG VHR + TG AVK V E+ +E +L A +P +V ++ Sbjct: 413 FGEVHRMKDKQTGFQCAVKKVRL---------EVFRVE-ELVACAGLSSPRIVPLYGAVR 462 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + W ++ M+L G L ++ + +PE A + Q + L H R ++H DVK Sbjct: 463 EGPWVNIFMELLEGGSLGQLIK--QMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKA 520 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 DNV+L D RA L DFG A + DG Sbjct: 521 DNVLLSSD------GSRAALCDFGHALCLQPDG 547
>OXSR1_MOUSE (Q6P9R2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 63.9 bits (154), Expect = 3e-10 Identities = 50/177 (28%), Positives = 82/177 (46%), Gaps = 9/177 (5%) Frame = +2 Query: 44 LNRD-YXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQL 220 +NRD Y VV E A+K ++ +D L EI+ + Sbjct: 12 INRDDYELQEVIGSGATAVVQAAYCAPKKERVAIKRINLEKCQTSMDELLKEIQA----M 67 Query: 221 AAAGNPGVVQVHA--VYEDDSWTHMVMDLCSGPDLLDWVRL------RRGAPVPEPVAAD 376 + +P +V + V +D+ W +VM L SG +LD ++ + + EP A Sbjct: 68 SQCHHPNIVSYYTSFVVKDELW--LVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEPTIAT 125 Query: 377 IVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 I+ ++ + L H+ G IHRDVK N++L GE+GS ++ADFG +A++ G Sbjct: 126 ILREVLEGLEYLHKNGQIHRDVKAGNILL-----GEDGS--VQIADFGVSAFLATGG 175
>CCAMK_PEA (Q6RET6) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (PsCCaMK) (Ps-SYM9) (Fragment) Length = 527 Score = 63.9 bits (154), Expect = 3e-10 Identities = 37/97 (38%), Positives = 58/97 (59%), Gaps = 1/97 (1%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P V+ ++ VYED + H+V++LCSG +L D R+ E A+ +V Q+ L Sbjct: 113 HPNVIDLYDVYEDTNGVHLVLELCSGGELFD--RIVAQDKYSETEASTVVHQIVAGLEAI 170 Query: 413 HRRGVIHRDVKPDN-VVLDVDDEGENGSPRARLADFG 520 HR +IHRD+KP+N + LDV G++ S ++ DFG Sbjct: 171 HRANIIHRDLKPENCLFLDV---GKDSS--LKIMDFG 202
>DAPK1_HUMAN (P53355) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1432 Score = 63.9 bits (154), Expect = 3e-10 Identities = 40/149 (26%), Positives = 77/149 (51%), Gaps = 3/149 (2%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDD---LDRELAEIEPKLAQLAAAGNPGVVQVHA 259 F VV +C +STG +A K + + + RE +IE +++ L +P V+ +H Sbjct: 24 FAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRE--DIEREVSILKEIQHPNVITLHE 81 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 VYE+ + ++++L +G +L D++ + + E A + + Q+ + H + H D Sbjct: 82 VYENKTDVILILELVAGGELFDFLAEKES--LTEEEATEFLKQILNGVYYLHSLQIAHFD 139 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFGSA 526 +KP+N++L + PR ++ DFG A Sbjct: 140 LKPENIML---LDRNVPKPRIKIIDFGLA 165
>KOK0_YEAST (Q12236) Probable serine/threonine-protein kinase YOL100W (EC| 2.7.11.1) Length = 1081 Score = 63.9 bits (154), Expect = 3e-10 Identities = 41/159 (25%), Positives = 75/159 (47%) Frame = +2 Query: 50 RDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAA 229 +D+ + V TS T + +A K +++ L + IE K A Sbjct: 177 KDFKFGSVIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIE-KTALQKLN 235 Query: 230 GNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALAL 409 +P VV++ + ++D+S + +++ D L +++ + E A AQ+ A+ Sbjct: 236 NSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSL--MKKYGSLDETCARYYAAQIIDAIDY 293 Query: 410 CHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 H G+IHRD+KP+N++LD G + +L DFG+A Sbjct: 294 LHSNGIIHRDIKPENILLD-------GEMKIKLTDFGTA 325
>KPC2_DROME (P13677) Protein kinase C, eye isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(EY)) (Protein INAC) (Inactivation no after-potential C protein) (Photoreceptor-specific PKC) (Eye-PKC) Length = 700 Score = 63.9 bits (154), Expect = 3e-10 Identities = 47/145 (32%), Positives = 71/145 (48%), Gaps = 1/145 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPG-VVQVHAVY 265 FG V R T E +AVK + + + D EL E K+ LA +G P +V +H+ + Sbjct: 382 FGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKI--LALSGRPPFLVSMHSCF 439 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 + VM+ C G DL+ +++ E VA ++A AL H R +I+RD+K Sbjct: 440 QTMDRLFFVMEYCKGGDLM--YHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLK 497 Query: 446 PDNVVLDVDDEGENGSPRARLADFG 520 DN++LD G +L DFG Sbjct: 498 LDNILLD-------GEGHVKLVDFG 515
>KCC1G_MOUSE (Q91VB2) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 477 Score = 63.9 bits (154), Expect = 3e-10 Identities = 42/144 (29%), Positives = 74/144 (51%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V R TG+ FA+K + +S D + +E ++A L + +V + +YE Sbjct: 34 FSEVFLVKQRVTGKLFALKCIKKSPAFRD-----SSLENEIAVLKRIKHENIVTLEDIYE 88 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM L SG +L D + L RG E A+ ++ Q+ A+ H G++HRD+KP Sbjct: 89 STTHYYLVMQLVSGGELFDRI-LERGV-YTEKDASLVIQQVLSAVKYLHENGIVHRDLKP 146 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++ +E + + + DFG Sbjct: 147 ENLLYLTPEE----NSKIMITDFG 166
>PHKG1_RABIT (P00518) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 63.5 bits (153), Expect = 4e-10 Identities = 41/147 (27%), Positives = 73/147 (49%), Gaps = 5/147 (3%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEI-EPKLAQL----AAAGNPGVVQVHA 259 VV RC + T + +AVK +D + E+ E+ E L ++ +G+P ++Q+ Sbjct: 32 VVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSGHPNIIQLKD 91 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 YE +++ +V DL +L D+ L + E I+ L + + H+ ++HRD Sbjct: 92 TYETNTFFFLVFDLMKKGELFDY--LTEKVTLSEKETRKIMRALLEVICALHKLNIVHRD 149 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFG 520 +KP+N++LD D +L DFG Sbjct: 150 LKPENILLDDD-------MNIKLTDFG 169
>PHKG1_MOUSE (P07934) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 63.5 bits (153), Expect = 4e-10 Identities = 40/147 (27%), Positives = 73/147 (49%), Gaps = 5/147 (3%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEI-EPKLAQL----AAAGNPGVVQVHA 259 VV RC + T + +AVK +D + E+ E+ E L ++ +G+P ++Q+ Sbjct: 32 VVRRCIHKPTCQEYAVKIIDITGGGSFSSEEVQELREATLKEVDILQKVSGHPNIIQLKD 91 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 YE +++ +V DL +L D+ L + E I+ L + + H+ ++HRD Sbjct: 92 TYETNTFFFLVFDLMKRGELFDY--LTEKVTLTEKETRKIMRALLEVICTLHKLNIVHRD 149 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFG 520 +KP+N++LD + +L DFG Sbjct: 150 LKPENILLD-------DNMNIKLTDFG 169
>ULK2_MOUSE (Q9QY01) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2) Length = 1037 Score = 63.5 bits (153), Expect = 4e-10 Identities = 42/152 (27%), Positives = 79/152 (51%), Gaps = 3/152 (1%) Frame = +2 Query: 89 FGVVHRCTSRS-TGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVY 265 F VV R R T A+KS+++ NL + + ++ L + +V ++ V Sbjct: 20 FAVVFRGRHRQKTDWEVAIKSINKKNL----SKSQILLGKEIKILKELQHENIVALYDVQ 75 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E + +VM+ C+G DL D+++ + + E + Q+A A+ + H +G+IHRD+K Sbjct: 76 ELPNSVFLVMEYCNGGDLADYLQAK--GTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLK 133 Query: 446 PDNVVLDVDDEGEN--GSPRARLADFGSAAWI 535 P N++L + ++ R ++ADFG A ++ Sbjct: 134 PQNILLSYANRRKSNVSGIRIKIADFGFARYL 165
>SSK2_YEAST (P53599) MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of| sensor kinase 2) Length = 1579 Score = 63.5 bits (153), Expect = 4e-10 Identities = 47/157 (29%), Positives = 71/157 (45%), Gaps = 2/157 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDD--LDRELAEIEPKLAQLAAAGNPGVVQVHAV 262 FG V+ GE AVK + N+ D + + I+ +++ L +P +V + V Sbjct: 1277 FGRVYSAVDLDNGEILAVKEI---NIQDSKSMQKIFPLIKEEMSVLEILNHPNIVSYYGV 1333 Query: 263 YEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDV 442 ++ M+ C G L L G E V QL + LA H G++HRDV Sbjct: 1334 EVHRDKVNIFMEYCEGGSLA--ALLEHGRIEDEMVTQVYTLQLLEGLAYLHESGIVHRDV 1391 Query: 443 KPDNVVLDVDDEGENGSPRARLADFGSAAWIGADGGR 553 KP+N++LD NG + DFG+A I +G R Sbjct: 1392 KPENILLDF-----NGV--IKYVDFGAAKKIANNGTR 1421
>KGP1A_RABIT (O77676) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 63.5 bits (153), Expect = 4e-10 Identities = 39/137 (28%), Positives = 71/137 (51%) Frame = +2 Query: 128 EAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K + + ++ D +E E ++ Q A + +V+++ ++D + +M+M+ C Sbjct: 384 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQ--GAHSDFIVRLYRTFKDSKYLYMLMEACL 441 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G +L W LR + A + +A A H +G+I+RD+KP+N++LD Sbjct: 442 GGEL--WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD------- 492 Query: 488 GSPRARLADFGSAAWIG 538 A+L DFG A IG Sbjct: 493 HRGYAKLVDFGFAKKIG 509
>KGP1A_HUMAN (Q13976) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 63.5 bits (153), Expect = 4e-10 Identities = 39/137 (28%), Positives = 71/137 (51%) Frame = +2 Query: 128 EAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K + + ++ D +E E ++ Q A + +V+++ ++D + +M+M+ C Sbjct: 384 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQ--GAHSDFIVRLYRTFKDSKYLYMLMEACL 441 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G +L W LR + A + +A A H +G+I+RD+KP+N++LD Sbjct: 442 GGEL--WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD------- 492 Query: 488 GSPRARLADFGSAAWIG 538 A+L DFG A IG Sbjct: 493 HRGYAKLVDFGFAKKIG 509
>KGP1A_BOVIN (P00516) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 63.5 bits (153), Expect = 4e-10 Identities = 39/137 (28%), Positives = 71/137 (51%) Frame = +2 Query: 128 EAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K + + ++ D +E E ++ Q A + +V+++ ++D + +M+M+ C Sbjct: 384 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQ--GAHSDFIVRLYRTFKDSKYLYMLMEACL 441 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G +L W LR + A + +A A H +G+I+RD+KP+N++LD Sbjct: 442 GGEL--WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD------- 492 Query: 488 GSPRARLADFGSAAWIG 538 A+L DFG A IG Sbjct: 493 HRGYAKLVDFGFAKKIG 509
>CHK1_CHICK (Q8AYC9) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 63.5 bits (153), Expect = 4e-10 Identities = 44/149 (29%), Positives = 74/149 (49%), Gaps = 3/149 (2%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDR---SNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHA 259 +G V +R T EA AVK VD ++ P+++ +E+ I L + VV+ + Sbjct: 20 YGEVQLAVNRRTEEAVAVKIVDMKRAADCPENIKKEIC-INKML------NHENVVKFYG 72 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 + + ++ ++ CSG +L D R+ +PEP A QL + H G+ HRD Sbjct: 73 HRREGATQYLFLEYCSGGELFD--RIEPDIGMPEPEAQRFFQQLIAGVVYLHSMGITHRD 130 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFGSA 526 +KP+N++LD D +++DFG A Sbjct: 131 LKPENLLLDERD-------NLKISDFGLA 152
>STK39_HUMAN (Q9UEW8) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT) Length = 547 Score = 63.5 bits (153), Expect = 4e-10 Identities = 46/159 (28%), Positives = 78/159 (49%), Gaps = 8/159 (5%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHA--VYE 268 VV + E A+K ++ +D L EI+ ++ +P VV + V + Sbjct: 78 VVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQA----MSQCSHPNVVTYYTSFVVK 133 Query: 269 DDSWTHMVMDLCSGPDLLDWVRL------RRGAPVPEPVAADIVAQLAQALALCHRRGVI 430 D+ W +VM L SG +LD ++ + + E + A I+ ++ + L HR G I Sbjct: 134 DELW--LVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQI 191 Query: 431 HRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 HRD+K N++L GE+GS ++ADFG +A++ G Sbjct: 192 HRDLKAGNILL-----GEDGS--VQIADFGVSAFLATGG 223
>KGP1B_MOUSE (Q9Z0Z0) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 63.5 bits (153), Expect = 4e-10 Identities = 39/137 (28%), Positives = 71/137 (51%) Frame = +2 Query: 128 EAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K + + ++ D +E E ++ Q A + +V+++ ++D + +M+M+ C Sbjct: 400 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQ--GAHSDFIVRLYRTFKDSKYLYMLMEACL 457 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G +L W LR + A + +A A H +G+I+RD+KP+N++LD Sbjct: 458 GGEL--WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD------- 508 Query: 488 GSPRARLADFGSAAWIG 538 A+L DFG A IG Sbjct: 509 HRGYAKLVDFGFAKKIG 525
>KGP1B_HUMAN (P14619) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 63.5 bits (153), Expect = 4e-10 Identities = 39/137 (28%), Positives = 71/137 (51%) Frame = +2 Query: 128 EAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K + + ++ D +E E ++ Q A + +V+++ ++D + +M+M+ C Sbjct: 400 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQ--GAHSDFIVRLYRTFKDSKYLYMLMEACL 457 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G +L W LR + A + +A A H +G+I+RD+KP+N++LD Sbjct: 458 GGEL--WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD------- 508 Query: 488 GSPRARLADFGSAAWIG 538 A+L DFG A IG Sbjct: 509 HRGYAKLVDFGFAKKIG 525
>KGP1B_BOVIN (P21136) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 63.5 bits (153), Expect = 4e-10 Identities = 39/137 (28%), Positives = 71/137 (51%) Frame = +2 Query: 128 EAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K + + ++ D +E E ++ Q A + +V+++ ++D + +M+M+ C Sbjct: 400 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQ--GAHSDFIVRLYRTFKDSKYLYMLMEACL 457 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G +L W LR + A + +A A H +G+I+RD+KP+N++LD Sbjct: 458 GGEL--WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD------- 508 Query: 488 GSPRARLADFGSAAWIG 538 A+L DFG A IG Sbjct: 509 HRGYAKLVDFGFAKKIG 525
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 63.5 bits (153), Expect = 4e-10 Identities = 44/146 (30%), Positives = 73/146 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV C R TG+ FA+K +D++ +E IE +++ L +P ++ + E Sbjct: 404 FAVVKECVDRYTGKEFALKIIDKAKC---CGKEHL-IENEVSILRRVKHPNIIMLVEEME 459 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + +VM+L G DL D + E + +V LA AL H ++HRD+KP Sbjct: 460 TATDLFLVMELVKGGDLFD--AITSSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKP 517 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N+++ E +G+ +L DFG A Sbjct: 518 ENLLV---CEYPDGTKSLKLGDFGLA 540
>STK39_RAT (O88506) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (Pancreatic serine/threonine-protein kinase) (PS/TK) (PSTK1) Length = 553 Score = 63.5 bits (153), Expect = 4e-10 Identities = 46/159 (28%), Positives = 78/159 (49%), Gaps = 8/159 (5%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHA--VYE 268 VV + E A+K ++ +D L EI+ ++ +P VV + V + Sbjct: 85 VVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQA----MSQCSHPNVVTYYTSFVVK 140 Query: 269 DDSWTHMVMDLCSGPDLLDWVRL------RRGAPVPEPVAADIVAQLAQALALCHRRGVI 430 D+ W +VM L SG +LD ++ + + E + A I+ ++ + L HR G I Sbjct: 141 DELW--LVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQI 198 Query: 431 HRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 HRD+K N++L GE+GS ++ADFG +A++ G Sbjct: 199 HRDLKAGNILL-----GEDGS--VQIADFGVSAFLATGG 230
>KPCE_RAT (P09216) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 63.5 bits (153), Expect = 4e-10 Identities = 46/174 (26%), Positives = 80/174 (45%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDL 178 P EN G+ R ++ FG V + E +AVK + + + D Sbjct: 389 PGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDD 448 Query: 179 DRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 D + E ++ LA +P + Q++ ++ VM+ +G DL+ +++R Sbjct: 449 DVDCTMTEKRILALARK-HPYLTQLYCCFQTKDRLFFVMEYVNGGDLM--FQIQRSRKFD 505 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP + A++ AL H+ GVI+RD+K DN++LD + ++LADFG Sbjct: 506 EPRSGFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEG-------HSKLADFG 552
>KPCL_RAT (Q64617) Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta)| (PKC-L) Length = 683 Score = 63.5 bits (153), Expect = 4e-10 Identities = 45/144 (31%), Positives = 71/144 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + TGE +AVK + + + D D E E ++ LA +P + Q+ ++ Sbjct: 366 FGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLAR-NHPFLTQLFCCFQ 424 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 VM+ +G DL+ +++ E A A++ AL H +G+I+RD+K Sbjct: 425 TPDRLFFVMEFVNGGDLM--FHIQKSRRFDEARARFYAAEIISALMFLHEKGIIYRDLKL 482 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DNV+L D EG +LADFG Sbjct: 483 DNVLL--DHEG-----HCKLADFG 499
>KPCL_MOUSE (P23298) Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta)| (PKC-L) Length = 683 Score = 63.5 bits (153), Expect = 4e-10 Identities = 45/144 (31%), Positives = 71/144 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + TGE +AVK + + + D D E E ++ LA +P + Q+ ++ Sbjct: 366 FGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLAR-NHPFLTQLFCCFQ 424 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 VM+ +G DL+ +++ E A A++ AL H +G+I+RD+K Sbjct: 425 TPDRLFFVMEFVNGGDLM--FHIQKSRRFDEARARFYAAEIISALMFLHEKGIIYRDLKL 482 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DNV+L D EG +LADFG Sbjct: 483 DNVLL--DHEG-----HCKLADFG 499
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 63.5 bits (153), Expect = 4e-10 Identities = 39/109 (35%), Positives = 57/109 (52%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 L+A +P VV++ E +VM+ G L D + P+P A ++ QLA+ Sbjct: 65 LSAVEHPAVVRIVDFGESGDHACLVMEFVEGESLYD---VLTPGPMPPGRALPLLQQLAE 121 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGAD 544 LA H +G+IHRD+KP+NV + GE +ARL DFG A + D Sbjct: 122 GLAAIHDKGIIHRDLKPENVFISKSARGE----QARLLDFGIARLVEPD 166
>ATG1_DEBHA (Q6BS08) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 875 Score = 63.5 bits (153), Expect = 4e-10 Identities = 52/181 (28%), Positives = 80/181 (44%), Gaps = 32/181 (17%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V++C + T E+ A+KSV RS L E EIE ++ L +P +V + + Sbjct: 33 FATVYKCFNTKTNESVAIKSVVRSKLKSKKLVENLEIE--ISILKTMKHPHIVGLLDYKQ 90 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVA--------------------- 385 S H+VMD CS DL ++R R PV + ++ Sbjct: 91 TTSHFHLVMDYCSMGDLSYFIRKRNQLIKTHPVISSLLERYPSPEGSHGLNEVLVIHFLK 150 Query: 386 QLAQALALCHRRGVIHRDVKPDNVVL--------DVDDEGENG---SPRARLADFGSAAW 532 QL AL + ++HRD+KP N++L + D G G P ++ADFG A + Sbjct: 151 QLVSALEFLRNKSLVHRDIKPQNLLLCPPLHSKQEFKDGGFVGLWELPLLKIADFGFARF 210 Query: 533 I 535 + Sbjct: 211 L 211
>CDK2_MESAU (P48963) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 63.5 bits (153), Expect = 4e-10 Identities = 43/154 (27%), Positives = 74/154 (48%), Gaps = 4/154 (2%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSV----DRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVH 256 +GVV++ ++ TGE A+K + + +P RE++ L +P +V++ Sbjct: 15 YGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREIS-------LLKELNHPNIVKLL 67 Query: 257 AVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHR 436 V ++ ++V +L DL ++ +P P+ + QL Q LA CH V+HR Sbjct: 68 DVIHTENKLYLVFELLH-QDLKKFMDASAVTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 Query: 437 DVKPDNVVLDVDDEGENGSPRARLADFGSAAWIG 538 D+KP N+++ N +LADFG A G Sbjct: 127 DLKPQNLLI-------NAEGSIKLADFGLARAFG 153
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 63.5 bits (153), Expect = 4e-10 Identities = 42/154 (27%), Positives = 74/154 (48%), Gaps = 4/154 (2%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSV----DRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVH 256 +GVV++ ++ TGE A+K + + +P RE++ L +P +V++H Sbjct: 15 YGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIREIS-------LLKELNHPNIVKLH 67 Query: 257 AVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHR 436 V ++ ++V + DL ++ + P+ + QL Q LA CH V+HR Sbjct: 68 DVIHTENKLYLVFEFLH-QDLKRFMDSSTVTGISLPLVKSYLFQLLQGLAFCHSHRVLHR 126 Query: 437 DVKPDNVVLDVDDEGENGSPRARLADFGSAAWIG 538 D+KP N++++ E +LADFG A G Sbjct: 127 DLKPQNLLINAQGE-------IKLADFGLARAFG 153
>STK39_MOUSE (Q9Z1W9) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) Length = 556 Score = 63.5 bits (153), Expect = 4e-10 Identities = 46/159 (28%), Positives = 78/159 (49%), Gaps = 8/159 (5%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHA--VYE 268 VV + E A+K ++ +D L EI+ ++ +P VV + V + Sbjct: 88 VVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQA----MSQCSHPNVVTYYTSFVVK 143 Query: 269 DDSWTHMVMDLCSGPDLLDWVRL------RRGAPVPEPVAADIVAQLAQALALCHRRGVI 430 D+ W +VM L SG +LD ++ + + E + A I+ ++ + L HR G I Sbjct: 144 DELW--LVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQI 201 Query: 431 HRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 HRD+K N++L GE+GS ++ADFG +A++ G Sbjct: 202 HRDLKAGNILL-----GEDGS--VQIADFGVSAFLATGG 233
>PHKG1_RAT (P13286) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 63.2 bits (152), Expect = 5e-10 Identities = 40/147 (27%), Positives = 73/147 (49%), Gaps = 5/147 (3%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEI-EPKLAQL----AAAGNPGVVQVHA 259 VV RC + T + +AVK +D + E+ E+ E L ++ +G+P ++Q+ Sbjct: 32 VVRRCIHKPTCQEYAVKIIDITGGGSFSSEEVQELREATLKEVDILQKVSGHPNIIQLKD 91 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 YE +++ +V DL +L D+ L + E I+ L + + H+ ++HRD Sbjct: 92 TYETNTFFFLVFDLMKRGELFDY--LTEKVTLTEKETRKIMRALLEVVCTLHKLNIVHRD 149 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFG 520 +KP+N++LD + +L DFG Sbjct: 150 LKPENILLD-------DNMNIKLTDFG 169
>MRCKB_MOUSE (Q7TT50) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1713 Score = 63.2 bits (152), Expect = 5e-10 Identities = 48/154 (31%), Positives = 78/154 (50%), Gaps = 1/154 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDR-ELAEIEPKLAQLAAAGNPGVVQVHAVY 265 FG V R+T +A+K +++ + L R E A + L + +H + Sbjct: 87 FGEVAVVKMRNTERIYAMKILNKWEM---LKRAETACFREERDVLVNGDCQWITALHYAF 143 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 +D+++ ++VMD G DLL + + +PE +A + ++ A+ H+ +HRD+K Sbjct: 144 QDENYLYLVMDYYVGGDLLTLLS-KFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIK 202 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 PDNV+LDV NG RLADFGS + DG Sbjct: 203 PDNVLLDV-----NG--HIRLADFGSCLKMNDDG 229
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 63.2 bits (152), Expect = 5e-10 Identities = 38/134 (28%), Positives = 68/134 (50%) Frame = +2 Query: 125 GEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLC 304 G+ V RSN +D D +A + + +A +P +V + V E +S ++VM+ Sbjct: 35 GDRLVAIKVLRSNFEND-DIAIARFQREAFAMAELSHPNIVGISDVGEFESQQYIVMEFV 93 Query: 305 SGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGE 484 G L ++ + AP+ A +I+ ++ A+ + H G+IHRD+KP NV++ Sbjct: 94 DGMTLKQYIN--QNAPLANDEAIEIITEILSAMDMAHSHGIIHRDLKPQNVLV------- 144 Query: 485 NGSPRARLADFGSA 526 + S ++ DFG A Sbjct: 145 SSSGTVKVTDFGIA 158
>PKNH_MYCTU (Q11053) Probable serine/threonine-protein kinase pknH (EC| 2.7.11.1) Length = 626 Score = 63.2 bits (152), Expect = 5e-10 Identities = 49/131 (37%), Positives = 65/131 (49%) Frame = +2 Query: 137 AVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPD 316 AVK + D + RE + E ++A P VV +H E D + M L G D Sbjct: 43 AVKLMTAEFSKDPVFRERMKREARIA--GRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD 100 Query: 317 LLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSP 496 L D V L+R P+ P A I+ Q+A AL H GV+HRDVKP N+++ DD Sbjct: 101 L-DSV-LKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRDD------- 151 Query: 497 RARLADFGSAA 529 A L DFG A+ Sbjct: 152 FAYLVDFGIAS 162
>PKNH_MYCBO (Q7U095) Probable serine/threonine-protein kinase pknH (EC| 2.7.11.1) Length = 596 Score = 63.2 bits (152), Expect = 5e-10 Identities = 49/131 (37%), Positives = 65/131 (49%) Frame = +2 Query: 137 AVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPD 316 AVK + D + RE + E ++A P VV +H E D + M L G D Sbjct: 43 AVKLMTAEFSKDPVFRERMKREARIA--GRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD 100 Query: 317 LLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSP 496 L D V L+R P+ P A I+ Q+A AL H GV+HRDVKP N+++ DD Sbjct: 101 L-DSV-LKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRDD------- 151 Query: 497 RARLADFGSAA 529 A L DFG A+ Sbjct: 152 FAYLVDFGIAS 162
>KCC4_MOUSE (P08414) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 469 Score = 63.2 bits (152), Expect = 5e-10 Identities = 38/144 (26%), Positives = 78/144 (54%), Gaps = 2/144 (1%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V+RC + T + +A+K + ++ +D+++ E + L +P ++++ ++E Sbjct: 55 IVYRCKQKGTQKPYALKVLKKT-----VDKKIVRTE--IGVLLRLSHPNIIKLKEIFETP 107 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 + +V++L +G +L D R+ E A D V Q+ +A+A H G++HRD+KP+N Sbjct: 108 TEISLVLELVTGGELFD--RIVEKGYYSERDARDAVKQILEAVAYLHENGIVHRDLKPEN 165 Query: 455 VVLDVDDEGENGSPRA--RLADFG 520 ++ +P A ++ADFG Sbjct: 166 LLY------ATPAPDAPLKIADFG 183
>MYO3A_HUMAN (Q8NEV4) Myosin IIIA (EC 2.7.11.1)| Length = 1616 Score = 63.2 bits (152), Expect = 5e-10 Identities = 50/156 (32%), Positives = 81/156 (51%), Gaps = 9/156 (5%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVY- 265 +G V + ++ G+ AVK +D + D+D E+ E E + + A + +P VV+ + +Y Sbjct: 32 YGKVFKVLNKKNGQKAAVKILDPIH---DIDEEI-EAEYNILK-ALSDHPNVVRFYGIYF 86 Query: 266 ------EDDSWTHMVMDLCSGPDLLDWVR--LRRGAPVPEPVAADIVAQLAQALALCHRR 421 D W +V++LCSG + D V+ L+RG + EP+ A I+ + L H Sbjct: 87 KKDKVNGDKLW--LVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLHNN 144 Query: 422 GVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 IHRDVK +N++L E G +L DFG +A Sbjct: 145 KTIHRDVKGNNILLTT----EGG---VKLVDFGVSA 173
>KPCE_HUMAN (Q02156) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 62.8 bits (151), Expect = 6e-10 Identities = 46/174 (26%), Positives = 79/174 (45%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDL 178 P EN G+ R ++ FG V + E +AVK + + + D Sbjct: 389 PGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDD 448 Query: 179 DRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 D + E ++ LA +P + Q++ ++ VM+ +G DL+ +++R Sbjct: 449 DVDCTMTEKRILALARK-HPYLTQLYCCFQTKDRLFFVMEYVNGGDLM--FQIQRSRKFD 505 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP + A++ AL H+ GVI+RD+K DN++LD + +LADFG Sbjct: 506 EPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEG-------HCKLADFG 552
>CDPK3_PLAYO (Q7RAV5) Calcium-dependent protein kinase 3 (EC 2.7.11.1)| Length = 538 Score = 62.8 bits (151), Expect = 6e-10 Identities = 42/148 (28%), Positives = 78/148 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +G V++ T + AVK V + L + + ++ + +P V+++ +E Sbjct: 123 YGCVYKATDKLLKIQRAVKVVSKKKL-----KNIPRFRQEIDIMKNLDHPNVIKLLETFE 177 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ +++MDLC+G +L D + +++G+ V E A+ I+ Q+ L H R + HRD+KP Sbjct: 178 DEEQIYLIMDLCTGGELFDKI-IKKGSFV-EMYASFIMKQIFSVLNYLHIRNICHRDIKP 235 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAW 532 +N L D E+ ++ DFG AA+ Sbjct: 236 EN-FLFYDKSTES---LIKIIDFGLAAY 259
>ST17A_HUMAN (Q9UEE5) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) Length = 414 Score = 62.8 bits (151), Expect = 6e-10 Identities = 40/144 (27%), Positives = 69/144 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV +C + +G+ FA K + + D E+ E + +LA NP V+ +H VYE Sbjct: 72 FAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIH-EIAVLELAQ-DNPWVINLHEVYE 129 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S +V++ +G ++ D R E ++ Q+ + + H R V+H D+KP Sbjct: 130 TASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKP 189 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 N++L E+ ++ DFG Sbjct: 190 QNILL----TSESPLGDIKIVDFG 209
>MAST3_HUMAN (O60307) Microtubule-associated serine/threonine-protein kinase 3| (EC 2.7.11.1) Length = 1309 Score = 62.8 bits (151), Expect = 6e-10 Identities = 43/156 (27%), Positives = 70/156 (44%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ +G V+ R T + FA+K +++ NL L ++ ++ + L A Sbjct: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLI--LRNQIQQVFVERDILTFAE 423 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 NP VV + +E MVM+ G D L+ P+P +A A+ AL Sbjct: 424 NPFVVSMFCSFETRRHLCMVMEYVEGGDCA--TLLKNMGPLPVDMARLYFAETVLALEYL 481 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H G++HRD+KPDN+++ +L DFG Sbjct: 482 HNYGIVHRDLKPDNLLI-------TSLGHIKLTDFG 510
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 62.8 bits (151), Expect = 6e-10 Identities = 42/154 (27%), Positives = 74/154 (48%), Gaps = 4/154 (2%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSV----DRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVH 256 +GVV++ ++ TGE A+K + + +P RE++ L +P +V++ Sbjct: 15 YGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREIS-------LLKELNHPNIVKLL 67 Query: 257 AVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHR 436 V ++ ++V + DL ++ +P P+ + QL Q LA CH V+HR Sbjct: 68 DVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 Query: 437 DVKPDNVVLDVDDEGENGSPRARLADFGSAAWIG 538 D+KP N++++ D +LADFG A G Sbjct: 127 DLKPQNLLINADGS-------IKLADFGLARAFG 153
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 62.8 bits (151), Expect = 6e-10 Identities = 41/147 (27%), Positives = 80/147 (54%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V + TG+ A+K + +S + + R + +I+ +++ + +P +V+++ V Sbjct: 22 FAKVKFARNTDTGDNVAIKIMAKSTILKN--RMVDQIKREISIMKIVRHPNIVRLYEVLA 79 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S ++V++ +G +L D R+ + E + QL A+A CH +GV HRD+KP Sbjct: 80 SPSKIYIVLEFVTGGELFD--RIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKP 137 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAA 529 +N++LD NG+ +++DFG +A Sbjct: 138 ENLLLDT-----NGN--LKVSDFGLSA 157
>ST17B_HUMAN (O94768) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 372 Score = 62.4 bits (150), Expect = 8e-10 Identities = 41/152 (26%), Positives = 76/152 (50%), Gaps = 2/152 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGN-PGVVQVHAVY 265 F VV +C S+STG+ +A K + + D AEI ++A L A + P V+ +H VY Sbjct: 44 FAVVRQCISKSTGQEYAAKFLKKRRRGQDCR---AEILHEIAVLELAKSCPRVINLHEVY 100 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E+ S ++++ +G ++ V E ++ Q+ + + H+ ++H D+K Sbjct: 101 ENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLK 160 Query: 446 PDNVVL-DVDDEGENGSPRARLADFGSAAWIG 538 P N++L + G+ ++ DFG + IG Sbjct: 161 PQNILLSSIYPLGD-----IKIVDFGMSRKIG 187
>NRC2_NEUCR (O42626) Serine/threonine-protein kinase nrc-2 (EC 2.7.11.1)| (Nonrepressible conidiation protein 2) Length = 623 Score = 62.4 bits (150), Expect = 8e-10 Identities = 35/126 (27%), Positives = 68/126 (53%), Gaps = 2/126 (1%) Frame = +2 Query: 92 GVVHRCTSRSTGEAFAVKSVDRSNL--PDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVY 265 G V+ + +G +A+K + + + + + R LAE E LA + +P +V ++ + Sbjct: 254 GKVYLVKEKKSGRLYAMKVLSKKEMIKRNKIKRALAEQEI----LATSNHPFIVTLYHSF 309 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 + + + ++ M+ CSG + ++ R G +PE A A++ AL H G I+RD+K Sbjct: 310 QSEDYLYLCMEYCSGGEFFRALQTRPGKCIPEDDARFYAAEVTAALEYLHLMGFIYRDLK 369 Query: 446 PDNVVL 463 P+N++L Sbjct: 370 PENILL 375
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 62.4 bits (150), Expect = 8e-10 Identities = 42/136 (30%), Positives = 73/136 (53%), Gaps = 3/136 (2%) Frame = +2 Query: 137 AVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPD 316 AVK +++ NL + L E K+ L + +V ++ E + ++VM+ C+G D Sbjct: 44 AVKCINKKNLAKS--QTLLGKEIKI--LKELKHENIVALYDFQEMANSVYLVMEYCNGGD 99 Query: 317 LLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSP 496 L D++ R + E + Q+A A+ L H +G+IHRD+KP N++L + G +P Sbjct: 100 LADYLHAMR--TLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLS-NPAGRRANP 156 Query: 497 ---RARLADFGSAAWI 535 R ++ADFG A ++ Sbjct: 157 NSIRVKIADFGFARYL 172
>KPCE_MOUSE (P16054) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 62.4 bits (150), Expect = 8e-10 Identities = 46/174 (26%), Positives = 79/174 (45%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDL 178 P EN G+ R ++ FG V + E +AVK + + + D Sbjct: 389 PGENGEVRPGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDD 448 Query: 179 DRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 D + E ++ LA +P + Q++ ++ VM+ +G DL+ +++R Sbjct: 449 DVDCTMTEKRILALARK-HPYLTQLYCCFQTKDRLFFVMEYVNGGDLM--FQIQRSRKFD 505 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP + A++ AL H+ GVI+RD+K DN++LD + +LADFG Sbjct: 506 EPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEG-------HCKLADFG 552
>CEK1_SCHPO (P38938) Serine/threonine-protein kinase cek1 (EC 2.7.11.1)| Length = 1338 Score = 62.4 bits (150), Expect = 8e-10 Identities = 44/168 (26%), Positives = 78/168 (46%), Gaps = 12/168 (7%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 DY FG V+ R+TG+ FA+K + +SN+ ++ + + A L + G Sbjct: 588 DYKILKPISKGAFGSVYLAQKRTTGDYFAIKILKKSNMI--AKNQVINVRAERAILMSQG 645 Query: 233 -NPGVVQVHAVYEDDSWTHMVMDLCSGPDL-----------LDWVRLRRGAPVPEPVAAD 376 +P V +++ ++ + ++VM+ +G D LDW+R Sbjct: 646 ESPFVAKLYYTFQSKDYLYLVMEYLNGGDCGSLLKTMGVLDLDWIRT------------- 692 Query: 377 IVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 +A+ L H RG+IHRD+KP+N+++ +NG +L DFG Sbjct: 693 YIAETVLCLGDLHDRGIIHRDIKPENLLI-----SQNG--HLKLTDFG 733
>ZYG1_CAEEL (Q9GT24) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 706 Score = 62.4 bits (150), Expect = 8e-10 Identities = 48/150 (32%), Positives = 79/150 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FGVV+ R GE A+K +D+ +P + R EI+ + +L + VV+ + + Sbjct: 24 FGVVY-AAQRENGEKVAIKRIDKK-VPKN--RVWTEIQT-MKELKKSKY--VVEFYEDFV 76 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 +D +T++VM+LC G L +VR GA + + A ++ QL A++ HR VIHRD+ Sbjct: 77 EDGYTYIVMELCEGGSLQAYVR-EHGA-LDDATAVHVLRQLISAVSFMHRVNVIHRDLSA 134 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 NV + + + +L DFG A +G Sbjct: 135 GNVFI---KDSKKKKMTVKLGDFGLATTLG 161
>KGP1_DROME (Q03042) cGMP-dependent protein kinase, isozyme 1 (EC 2.7.11.12)| (CGK) Length = 768 Score = 62.4 bits (150), Expect = 8e-10 Identities = 37/137 (27%), Positives = 72/137 (52%) Frame = +2 Query: 128 EAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K + + ++ D E E + + ++ +P + +++ + D+ + +M+++ C Sbjct: 483 DIFALKCLKKRHIVDTKQEEHIFSERHI--MLSSRSPFICRLYRTFRDEKYVYMLLEACM 540 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G ++ W LR + A I+ + QA H RG+I+RD+KP+N++LD E Sbjct: 541 GGEI--WTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLD-----ER 593 Query: 488 GSPRARLADFGSAAWIG 538 G ++ DFG A IG Sbjct: 594 G--YVKIVDFGFAKQIG 608
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 62.4 bits (150), Expect = 8e-10 Identities = 42/136 (30%), Positives = 73/136 (53%), Gaps = 3/136 (2%) Frame = +2 Query: 137 AVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPD 316 AVK +++ NL + L E K+ L + +V ++ E + ++VM+ C+G D Sbjct: 44 AVKCINKKNLAKS--QTLLGKEIKI--LKELKHENIVALYDFQEMANSVYLVMEYCNGGD 99 Query: 317 LLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSP 496 L D++ R + E + Q+A A+ L H +G+IHRD+KP N++L + G +P Sbjct: 100 LADYLHTMR--TLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLS-NPGGRRANP 156 Query: 497 ---RARLADFGSAAWI 535 R ++ADFG A ++ Sbjct: 157 SNIRVKIADFGFARYL 172
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 62.0 bits (149), Expect = 1e-09 Identities = 44/158 (27%), Positives = 72/158 (45%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 D+ FG VH S G +A+K + + + E E ++ +L Sbjct: 69 DFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVE-- 126 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P ++++ ++D MVMD G +L LR+ P PVA A++ AL Sbjct: 127 HPFLIRMWGTFQDARNIFMVMDYIEGGELFSL--LRKSQRFPNPVAKFYAAEVILALEYL 184 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 H +I+RD+KP+N++LD NG ++ DFG A Sbjct: 185 HAHNIIYRDLKPENILLD-----RNG--HIKITDFGFA 215
>E2AK2_MOUSE (Q03963) Interferon-induced, double-stranded RNA-activated protein| kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein Length = 515 Score = 62.0 bits (149), Expect = 1e-09 Identities = 46/194 (23%), Positives = 79/194 (40%), Gaps = 16/194 (8%) Frame = +2 Query: 14 EENH*TMSGELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELA 193 + N T+ N D+ FG V + R G+ +A+K V + Sbjct: 228 QRNKYTLDARFNSDFEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNT---------E 278 Query: 194 EIEPKLAQLAAAGNPGVVQVHAVYEDDSWT----------------HMVMDLCSGPDLLD 325 + E ++ LA + +VQ H+ +E + + M+ C L Sbjct: 279 KAEHEVQALAELNHVNIVQYHSCWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDKGTLEQ 338 Query: 326 WVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRAR 505 W+R R + V + + D+ Q+ + H +G+IHRD+KP N+ L VD+ + Sbjct: 339 WMRNRNQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFL-VDER------HIK 391 Query: 506 LADFGSAAWIGADG 547 + DFG A + DG Sbjct: 392 IGDFGLATALENDG 405
>MRCKB_RAT (Q7TT49) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1713 Score = 62.0 bits (149), Expect = 1e-09 Identities = 36/102 (35%), Positives = 58/102 (56%) Frame = +2 Query: 242 VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR 421 + +H ++D+++ ++VMD G DLL + + +PE +A + ++ A+ H+ Sbjct: 136 ITALHYAFQDENYLYLVMDYYVGGDLLTLLS-KFEDKLPEDMARFYIGEMVLAIDSIHQL 194 Query: 422 GVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 +HRD+KPDNV+LDV NG RLADFGS + DG Sbjct: 195 HYVHRDIKPDNVLLDV-----NG--HIRLADFGSCLKMNDDG 229
>KPCA_MOUSE (P20444) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 62.0 bits (149), Expect = 1e-09 Identities = 46/174 (26%), Positives = 81/174 (46%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDL 178 P E+ S L+R D+ FG V + T E +A+K + + + D Sbjct: 319 PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 378 Query: 179 DRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 D E +E ++ L P + Q+H+ ++ + VM+ +G DL+ +++ Sbjct: 379 DVECTMVEKRVLALLDKP-PFLTQLHSCFQTVDRLYFVMEYVNGGDLM--YHIQQVGKFK 435 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP A A+++ L H+RG+I+RD+K +NV+L N ++ADFG Sbjct: 436 EPQAVFYAAEISIGLFFLHKRGIIYRDLKLNNVML-------NSEGHIKIADFG 482
>MYO3A_MOUSE (Q8K3H5) Myosin IIIA (EC 2.7.11.1)| Length = 1613 Score = 62.0 bits (149), Expect = 1e-09 Identities = 49/160 (30%), Positives = 83/160 (51%), Gaps = 9/160 (5%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVY- 265 +G V + ++ +G+ AVK +D + D+D E+ E E + + + +P VV+ + +Y Sbjct: 32 YGKVFKVLNKKSGQKAAVKILDPIH---DIDEEI-EAEYNILR-TLSDHPNVVRFYGIYF 86 Query: 266 ------EDDSWTHMVMDLCSGPDLLDWVR--LRRGAPVPEPVAADIVAQLAQALALCHRR 421 D W +V++LC+G + D V+ L+RG + EPV A I+ + L H Sbjct: 87 KKDKINGDKLW--LVLELCNGGSVTDLVKGFLKRGERMSEPVIAYILHEALMGLQHLHSN 144 Query: 422 GVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 IHRDVK +N++L E G +L DFG +A + + Sbjct: 145 KTIHRDVKGNNILLTT----EGG---VKLVDFGVSAQLSS 177
>MRCKA_HUMAN (Q5VT25) Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1)| (CDC42-binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha Length = 1732 Score = 62.0 bits (149), Expect = 1e-09 Identities = 47/154 (30%), Positives = 78/154 (50%), Gaps = 1/154 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDR-ELAEIEPKLAQLAAAGNPGVVQVHAVY 265 FG V ++ + FA+K +++ + L R E A + L N + +H + Sbjct: 88 FGEVAVVKLKNADKVFAMKILNKWEM---LKRAETACFREERDVLVNGDNKWITTLHYAF 144 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 +DD+ ++VMD G DLL + +PE +A +A++ A+ H+ +HRD+K Sbjct: 145 QDDNNLYLVMDYYVGGDLLTLLSKFEDR-LPEDMARFYLAEMVIAIDSVHQLHYVHRDIK 203 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 PDN+++D+ NG RLADFGS + DG Sbjct: 204 PDNILMDM-----NG--HIRLADFGSCLKLMEDG 230
>KPCE_RABIT (P10830) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 736 Score = 62.0 bits (149), Expect = 1e-09 Identities = 41/144 (28%), Positives = 71/144 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + E +AVK + + + D D + E ++ LA +P + Q++ ++ Sbjct: 418 FGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARK-HPYLTQLYCCFQ 476 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 VM+ +G DL+ +++R EP + A++ AL H+ GVI+RD+K Sbjct: 477 TKDRLFFVMEYVNGGDLM--FQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKL 534 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DN++LD + +LADFG Sbjct: 535 DNILLDAEG-------HCKLADFG 551
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/154 (27%), Positives = 73/154 (47%), Gaps = 4/154 (2%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSV----DRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVH 256 +GVV++ ++ TGE A+K + + +P RE++ L +P +V++ Sbjct: 15 YGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREIS-------LLKELNHPNIVKLL 67 Query: 257 AVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHR 436 V ++ ++V + DL ++ +P P+ + QL Q LA CH V+HR Sbjct: 68 DVIHTENKLYLVFEFLH-QDLKKFMDASAVTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 Query: 437 DVKPDNVVLDVDDEGENGSPRARLADFGSAAWIG 538 D+KP N+++ N +LADFG A G Sbjct: 127 DLKPQNLLI-------NAEGSIKLADFGLARAFG 153
>CDK5_XENLA (P51166) Cell division protein kinase 5 (EC 2.7.11.22) (Neuronal| cyclin-dependent kinase 5) Length = 292 Score = 62.0 bits (149), Expect = 1e-09 Identities = 45/150 (30%), Positives = 70/150 (46%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +G V + +R T E A+K V L DD + + ++ L + +V++H V Sbjct: 15 YGTVFKAKNRDTHEIVALKRV---RLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLH 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D +V + C DL + G PE + + QL + LA CH R V+HRD+KP Sbjct: 72 SDKKLTLVFEFCD-QDLKKYFDSCNGDLDPE-IVKSFMYQLLKGLAFCHSRNVLHRDLKP 129 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 N+++ N + +LADFG A G Sbjct: 130 QNLLI-------NRNGELKLADFGLARAFG 152
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/144 (29%), Positives = 72/144 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V TG AVK ++R + LD + +I ++ L +P +++++ V Sbjct: 29 FGKVKVGKHELTGHKVAVKILNRQKIRS-LD-VVGKIRREIQNLKLFRHPHIIKLYQVIS 86 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S MVM+ SG +L D++ + + E + + Q+ + CHR V+HRD+KP Sbjct: 87 TPSDIFMVMEYVSGGELFDYIC--KNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 144 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 145 ENVLLD-------AHMNAKIADFG 161
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/144 (29%), Positives = 72/144 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V TG AVK ++R + LD + +I ++ L +P +++++ V Sbjct: 29 FGKVKVGKHELTGHKVAVKILNRQKIRS-LD-VVGKIRREIQNLKLFRHPHIIKLYQVIS 86 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S MVM+ SG +L D++ + + E + + Q+ + CHR V+HRD+KP Sbjct: 87 TPSDIFMVMEYVSGGELFDYIC--KNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 144 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 145 ENVLLD-------AHMNAKIADFG 161
>CDKL4_MOUSE (Q3TZA2) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 342 Score = 62.0 bits (149), Expect = 1e-09 Identities = 39/125 (31%), Positives = 66/125 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +GVV +C ++S+G+ A+K S D + R++A E ++ L +P +V + V+ Sbjct: 15 YGVVFKCRNKSSGQVVAIKKFVESE-DDRVVRKIALREIRM--LKQLKHPNLVNLIEVFR 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 H+V + C L + R G V + V ++ Q QAL CH+ IHRDVKP Sbjct: 72 RKRKMHLVFEYCDHTLLNELERNPNG--VSDGVIKSVLWQTLQALNFCHKHNCIHRDVKP 129 Query: 449 DNVVL 463 +N+++ Sbjct: 130 ENILI 134
>CDK3_MOUSE (Q80YP0) Truncated cell division protein kinase 3 homolog| Length = 186 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/154 (27%), Positives = 75/154 (48%), Gaps = 4/154 (2%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSV----DRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVH 256 +GVV++ ++ TG+ A+K + + +P RE++ L +P ++++ Sbjct: 15 YGVVYKARNKVTGQLVALKKIRLDLEAEGVPSTAVREIS-------LLKELKHPNIIKLL 67 Query: 257 AVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHR 436 V + +MV + + DL + + +P PV +AQL + ++ CH VIHR Sbjct: 68 DVVHREKKLYMVFEFLT-QDLKRHMDSSPTSELPLPVVKSYLAQLLEGVSFCHSHRVIHR 126 Query: 437 DVKPDNVVLDVDDEGENGSPRARLADFGSAAWIG 538 D+KP N++LD G +LADFG A G Sbjct: 127 DLKPQNLLLD-------GLGAIKLADFGLARAFG 153
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/144 (29%), Positives = 72/144 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V TG AVK ++R + LD + +I ++ L +P +++++ V Sbjct: 27 FGKVKVGKHELTGHKVAVKILNRQKIRS-LD-VVGKIRREIQNLKLFRHPHIIKLYQVIS 84 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S MVM+ SG +L D++ + + E + + Q+ + CHR V+HRD+KP Sbjct: 85 TPSDIFMVMEYVSGGELFDYIC--KNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 143 ENVLLD-------AHMNAKIADFG 159
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/144 (29%), Positives = 72/144 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V TG AVK ++R + LD + +I ++ L +P +++++ V Sbjct: 27 FGKVKVGKHELTGHKVAVKILNRQKIRS-LD-VVGKIRREIQNLKLFRHPHIIKLYQVIS 84 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S MVM+ SG +L D++ + + E + + Q+ + CHR V+HRD+KP Sbjct: 85 TPSDIFMVMEYVSGGELFDYIC--KNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 143 ENVLLD-------AHMNAKIADFG 159
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 61.6 bits (148), Expect = 1e-09 Identities = 47/163 (28%), Positives = 76/163 (46%) Frame = +2 Query: 41 ELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQL 220 EL + Y F V TGE A+K +D++ L DL R EI+ L Sbjct: 6 ELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDA----L 61 Query: 221 AAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 + + + Q++ V E + MV++ C G +L D++ + + E + Q+ A Sbjct: 62 KSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQILSA 119 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 +A H +G HRD+KP+N++ D EN + +L DFG A Sbjct: 120 VAYVHSQGYAHRDLKPENLLFD-----EN--HKLKLIDFGLCA 155
>DAPK2_MOUSE (Q8VDF3) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 61.6 bits (148), Expect = 1e-09 Identities = 41/149 (27%), Positives = 76/149 (51%), Gaps = 3/149 (2%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDD---LDRELAEIEPKLAQLAAAGNPGVVQVHA 259 F +V +C +STG +A K + + + RE EIE +++ L +P ++ +H Sbjct: 34 FAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCRE--EIEREVSILRQVLHPNIITLHD 91 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 VYE+ + ++++L SG +L D+ L + + E A + Q+ + H + + H D Sbjct: 92 VYENRTDVVLILELVSGGELFDF--LAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFD 149 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFGSA 526 +KP+N++L + P +L DFG A Sbjct: 150 LKPENIML---LDKNIPIPHIKLIDFGLA 175
>TSSK3_MOUSE (Q9D2E1) Testis-specific serine/threonine-protein kinase 3 (EC| 2.7.11.1) (TSSK-3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C) Length = 268 Score = 61.6 bits (148), Expect = 1e-09 Identities = 45/162 (27%), Positives = 75/162 (46%), Gaps = 1/162 (0%) Frame = +2 Query: 44 LNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLA 223 L+ Y + V S+ A+K +D+ P++ + E ++ + Sbjct: 6 LSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKIIDKMGGPEEFIQRFLPRELQIVRTL 65 Query: 224 AAGNPGVVQVHAVYED-DSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 N ++QV+ + E D ++VM+L G D+ D V G P+PE A + Q+ +A Sbjct: 66 DHKN--IIQVYEMLESADGKIYLVMELAEGGDVFDCVL--NGGPLPESRAKALFRQMVEA 121 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 + CH GV HRD+K +N +L +G N +L DFG A Sbjct: 122 IRYCHGCGVAHRDLKCENALL----QGFN----LKLTDFGFA 155
>PKNE_MYCTU (P72001) Serine/threonine-protein kinase pknE (EC 2.7.11.1)| Length = 566 Score = 61.6 bits (148), Expect = 1e-09 Identities = 39/98 (39%), Positives = 50/98 (51%) Frame = +2 Query: 236 PGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCH 415 P VV +H E D ++ M L +G DL LRR P+ P A IV Q+ AL H Sbjct: 74 PHVVPIHDFGEIDGQLYVDMRLINGVDLA--AMLRRQGPLAPPRAVAIVRQIGSALDAAH 131 Query: 416 RRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 G HRDVKP+N+++ DD A L DFG A+ Sbjct: 132 AAGATHRDVKPENILVSADD-------FAYLVDFGIAS 162
>PKNE_MYCBO (Q7TZN3) Serine/threonine-protein kinase pknE (EC 2.7.11.1)| Length = 566 Score = 61.6 bits (148), Expect = 1e-09 Identities = 39/98 (39%), Positives = 50/98 (51%) Frame = +2 Query: 236 PGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCH 415 P VV +H E D ++ M L +G DL LRR P+ P A IV Q+ AL H Sbjct: 74 PHVVPIHDFGEIDGQLYVDMRLINGVDLA--AMLRRQGPLAPPRAVAIVRQIGSALDAAH 131 Query: 416 RRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 G HRDVKP+N+++ DD A L DFG A+ Sbjct: 132 AAGATHRDVKPENILVSADD-------FAYLVDFGIAS 162
>KPC3_DROME (P13678) Protein kinase C (EC 2.7.11.13) (PKC) (dPKC98F)| Length = 634 Score = 61.6 bits (148), Expect = 1e-09 Identities = 44/144 (30%), Positives = 71/144 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + T E +A+K + + + D D + E ++ LAA +P + +H+ ++ Sbjct: 314 FGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAA-NHPFLTALHSCFQ 372 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 VM+ +G DL+ ++ R AA A++ AL H GVI+RD+K Sbjct: 373 TPDRLFFVMEYVNGGDLMFQIQKARRFEASR--AAFYAAEVTLALQFLHTHGVIYRDLKL 430 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DN++L D EG +LADFG Sbjct: 431 DNILL--DQEG-----HCKLADFG 447
>NEK3_MOUSE (Q9R0A5) Serine/threonine-protein kinase Nek3 (EC 2.7.11.1)| (NimA-related protein kinase 3) Length = 511 Score = 61.6 bits (148), Expect = 1e-09 Identities = 41/146 (28%), Positives = 68/146 (46%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG S+ + FA+K + R+ A + LA +P +V +E Sbjct: 15 FGRALLVLQESSNQTFAMKEIRLLKSDTQTSRKEAVL------LAKMKHPNIVAFKESFE 68 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + + ++VM+ C G DL+ ++ ++G PE + Q+ + H+R V+HRD+K Sbjct: 69 AEGYLYIVMEYCDGGDLMQRIKQQKGNLFPEDTILNWFIQICLGVNHIHKRRVLHRDIKS 128 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 NV L NG + +L DFGSA Sbjct: 129 KNVFLT-----HNG--KVKLGDFGSA 147
>STK10_HUMAN (O94804) Serine/threonine-protein kinase 10 (EC 2.7.11.1)| (Lymphocyte-oriented kinase) Length = 968 Score = 61.6 bits (148), Expect = 1e-09 Identities = 41/147 (27%), Positives = 75/147 (51%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V++ ++ TG A K ++ + ++L+ + EIE LA +P +V++ Y Sbjct: 47 FGKVYKAKNKETGALAAAKVIETKS-EEELEDYIVEIEI----LATCDHPYIVKLLGAYY 101 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D ++++ C G +D + L + EP + Q+ +AL H + +IHRD+K Sbjct: 102 HDGKLWIMIEFCPG-GAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKA 160 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAA 529 NV++ ++ + RLADFG +A Sbjct: 161 GNVLMTLEGD-------IRLADFGVSA 180
>CDK2_MOUSE (P97377) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 346 Score = 61.6 bits (148), Expect = 1e-09 Identities = 42/154 (27%), Positives = 73/154 (47%), Gaps = 4/154 (2%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSV----DRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVH 256 +GVV++ ++ TGE A+K + + +P RE++ L +P +V++ Sbjct: 15 YGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREIS-------LLKELNHPNIVKLL 67 Query: 257 AVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHR 436 V ++ ++V + DL ++ +P P+ + QL Q LA CH V+HR Sbjct: 68 DVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 Query: 437 DVKPDNVVLDVDDEGENGSPRARLADFGSAAWIG 538 D+KP N+++ N +LADFG A G Sbjct: 127 DLKPQNLLI-------NAEGSIKLADFGLARAFG 153
>KPCI_PONPY (Q5R4K9) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| Length = 587 Score = 61.6 bits (148), Expect = 1e-09 Identities = 41/135 (30%), Positives = 74/135 (54%) Frame = +2 Query: 116 RSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVM 295 + T +A+K V + + DD D + + E + + A+ +P +V +H+ ++ +S V+ Sbjct: 265 KKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE-QASNHPFLVGLHSCFQTESRLFFVI 323 Query: 296 DLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDD 475 + +G DL+ ++R +PE A A+++ AL H RG+I+RD+K DNV+L D Sbjct: 324 EYVNGGDLM--FHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLL--DS 379 Query: 476 EGENGSPRARLADFG 520 EG +L D+G Sbjct: 380 EG-----HIKLTDYG 389
>KPCI_HUMAN (P41743) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota) Length = 587 Score = 61.6 bits (148), Expect = 1e-09 Identities = 41/135 (30%), Positives = 74/135 (54%) Frame = +2 Query: 116 RSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVM 295 + T +A+K V + + DD D + + E + + A+ +P +V +H+ ++ +S V+ Sbjct: 265 KKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE-QASNHPFLVGLHSCFQTESRLFFVI 323 Query: 296 DLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDD 475 + +G DL+ ++R +PE A A+++ AL H RG+I+RD+K DNV+L D Sbjct: 324 EYVNGGDLM--FHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLL--DS 379 Query: 476 EGENGSPRARLADFG 520 EG +L D+G Sbjct: 380 EG-----HIKLTDYG 389
>NAK1_SCHPO (O75011) Serine/threonine-protein kinase nak1 (EC 2.7.11.1) (N-rich| kinase 1) Length = 652 Score = 61.6 bits (148), Expect = 1e-09 Identities = 44/150 (29%), Positives = 74/150 (49%), Gaps = 3/150 (2%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLA---QLAAAGNPGVVQVHA 259 +G V+R T E A+K + NL D D E+++I+ ++A +L + +++ H Sbjct: 21 YGAVYRGICNLTKETVAIKIL---NLDTDED-EVSDIQKEVAVLSELKQSDVENIIKYHG 76 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 Y + ++MD C G + L P+ EP + I+ + QAL H G+IHRD Sbjct: 77 SYLVGTNLWIIMDYCHGGSVRT---LMEAGPISEPCISLILRETLQALKFIHHAGIIHRD 133 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFGSAA 529 +K N+++ + S +L DFG AA Sbjct: 134 IKAANILVSM-------SGNVKLCDFGVAA 156
>SNF1_CANAL (P52497) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 620 Score = 61.6 bits (148), Expect = 1e-09 Identities = 41/144 (28%), Positives = 76/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V TG+ A+K ++R L D + +E +++ L +P +++++ V + Sbjct: 64 FGKVKLAQHLGTGQKVALKIINRKTLAKS-DMQ-GRVEREISYLRLLRHPHIIKLYDVIK 121 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 MV++ +G +L D++ ++RG +PE A Q+ A+ CHR ++HRD+KP Sbjct: 122 SKDEIIMVIEF-AGKELFDYI-VQRGK-MPEDEARRFFQQIIAAVEYCHRHKIVHRDLKP 178 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++LD ++ADFG Sbjct: 179 ENLLLD-------DQLNVKIADFG 195
>KPCI_MOUSE (Q62074) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) Length = 586 Score = 61.6 bits (148), Expect = 1e-09 Identities = 41/135 (30%), Positives = 74/135 (54%) Frame = +2 Query: 116 RSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVM 295 + T +A+K V + + DD D + + E + + A+ +P +V +H+ ++ +S V+ Sbjct: 264 KKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE-QASNHPFLVGLHSCFQTESRLFFVI 322 Query: 296 DLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDD 475 + +G DL+ ++R +PE A A+++ AL H RG+I+RD+K DNV+L D Sbjct: 323 EYVNGGDLM--FHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLL--DS 378 Query: 476 EGENGSPRARLADFG 520 EG +L D+G Sbjct: 379 EG-----HIKLTDYG 388
>PKH3_YEAST (Q03306) Serine/threonine-protein kinase PKH3 (EC 2.7.11.1)| (Pkb-activating kinase homolog 3) Length = 898 Score = 61.6 bits (148), Expect = 1e-09 Identities = 40/141 (28%), Positives = 68/141 (48%), Gaps = 1/141 (0%) Frame = +2 Query: 116 RSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGN-PGVVQVHAVYEDDSWTHMV 292 +S + +A+K + ++ + + IE L A + G+++++ + D+ + V Sbjct: 32 KSPNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKHHAGIIKLYYTFHDEENLYFV 91 Query: 293 MDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVD 472 +D G +LL L + + AQL AL H G+IHRD+KP+NV+LD D Sbjct: 92 LDFAPGGELLSL--LHKMGTFNDIWTRHFTAQLIDALEFIHSHGIIHRDLKPENVLLDRD 149 Query: 473 DEGENGSPRARLADFGSAAWI 535 R + DFG+AA I Sbjct: 150 G-------RLMITDFGAAATI 163
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 61.6 bits (148), Expect = 1e-09 Identities = 49/158 (31%), Positives = 79/158 (50%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAG 232 +Y FGVV + ST E A+K + + L + + +L + +L+ L Sbjct: 46 NYIFGRTLGAGSFGVVRQARKLSTNEDVAIKILLKKALQGN-NVQLQMLYEELSILQKLS 104 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V +E ++V L +G +L D + L RG E A +I+ Q+ A+ Sbjct: 105 HPNIVSFKDWFESKDKFYIVTQLATGGELFDRI-LSRGK-FTEVDAVEIIVQILGAVEYM 162 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 H + V+HRD+KP+NV+ D+ EN SP +ADFG A Sbjct: 163 HSKNVVHRDLKPENVL--YVDKSEN-SPLV-IADFGIA 196
>CHK1_HUMAN (O14757) Serine/threonine-protein kinase Chk1 (EC 2.7.11.1)| Length = 476 Score = 61.2 bits (147), Expect = 2e-09 Identities = 44/149 (29%), Positives = 73/149 (48%), Gaps = 3/149 (2%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRS---NLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHA 259 +G V +R T EA AVK VD + P+++ +E+ I L + VV+ + Sbjct: 20 YGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEIC-INKML------NHENVVKFYG 72 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 + + ++ ++ CSG +L D R+ +PEP A QL + H G+ HRD Sbjct: 73 HRREGNIQYLFLEYCSGGELFD--RIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRD 130 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFGSA 526 +KP+N++LD D +++DFG A Sbjct: 131 IKPENLLLDERD-------NLKISDFGLA 152
>ATG1_USTMA (Q4P0K0) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 990 Score = 61.2 bits (147), Expect = 2e-09 Identities = 50/178 (28%), Positives = 77/178 (43%), Gaps = 32/178 (17%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VVH+ E A+K V R L L L +E ++A L A +P +V++ + Sbjct: 26 FAVVHKGYRLQPREPVAIKIVIRKKLTPKL---LDNLEGEIAILKAIHHPNIVELKECLK 82 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLR------RGAPVP--------------------EPVA 370 + ++VM C+ DL +++ R G P E + Sbjct: 83 TEHQIYLVMAFCASGDLAQYIKKRFDIYERAGMAEPDSLTKGFKPTYPHPVDGGLNETIV 142 Query: 371 ADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEG--ENGSPR----ARLADFGSA 526 I+ QLA AL R ++HRD+KP N++L D G+PR ++ADFG A Sbjct: 143 RSILTQLAAALEFMRARDIVHRDIKPQNLLLQPPDAAFLALGNPREIPQMKVADFGFA 200
>DCAK1_RAT (O08875) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) Length = 433 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/146 (28%), Positives = 73/146 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV C RST +A+K + +S I+ +++ L +P +V + + Sbjct: 94 FAVVKECIERSTAREYALKIIKKSKCRGKEHM----IQNEVSILRRVKHPNIVLLIEEMD 149 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM+L G DL D + + E A+ ++ LA A+ H ++HRD+KP Sbjct: 150 VPTELYLVMELVKGGDLFD--AITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKP 207 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N+++ E ++GS +L DFG A Sbjct: 208 ENLLV---YEHQDGSKSLKLGDFGLA 230
>KPCI_BRARE (Q90XF2) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (Heart and soul protein) Length = 588 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/135 (30%), Positives = 74/135 (54%) Frame = +2 Query: 116 RSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVM 295 + T +A+K V + + DD D + + E + + A+ +P +V +H+ ++ +S V+ Sbjct: 266 KKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFE-QASNHPFLVGLHSCFQTESRLFFVI 324 Query: 296 DLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDD 475 + +G DL+ ++R +PE A A+++ AL H RG+I+RD+K DNV+L D Sbjct: 325 EYVNGGDLM--FHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLL--DS 380 Query: 476 EGENGSPRARLADFG 520 EG +L D+G Sbjct: 381 EG-----HIKLTDYG 390
>DCAK1_MOUSE (Q9JLM8) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 756 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/146 (28%), Positives = 73/146 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV C RST +A+K + +S I+ +++ L +P +V + + Sbjct: 417 FAVVKECIERSTAREYALKIIKKSKCRGKEHM----IQNEVSILRRVKHPNIVLLIEEMD 472 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM+L G DL D + + E A+ ++ LA A+ H ++HRD+KP Sbjct: 473 VPTELYLVMELVKGGDLFD--AITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKP 530 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N+++ E ++GS +L DFG A Sbjct: 531 ENLLV---YEHQDGSKSLKLGDFGLA 553
>SNF1_CANTR (O94168) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 619 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/144 (28%), Positives = 76/144 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V TG+ A+K ++R L D + +E +++ L +P +++++ V + Sbjct: 63 FGKVKLAQHVGTGQKVALKIINRKTLAKS-DMQ-GRVEREISYLRLLRHPHIIKLYDVIK 120 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 MV++ +G +L D++ ++RG +PE A Q+ A+ CHR ++HRD+KP Sbjct: 121 SKDEIIMVIEF-AGKELFDYI-VQRGK-MPEDEARRFFQQIIAAVEYCHRHKIVHRDLKP 177 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++LD ++ADFG Sbjct: 178 ENLLLD-------DQLNVKIADFG 194
>CDK5_RAT (Q03114) Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein| kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 61.2 bits (147), Expect = 2e-09 Identities = 44/150 (29%), Positives = 70/150 (46%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +G V + +R T E A+K V L DD + + ++ L + +V++H V Sbjct: 15 YGTVFKAKNRETHEIVALKRV---RLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLH 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D +V + C DL + G PE + ++ QL + L CH R V+HRD+KP Sbjct: 72 SDKKLTLVFEFCD-QDLKKYFDSCNGDLDPE-IVKSLLFQLLKGLGFCHSRNVLHRDLKP 129 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 N+++ N + +LADFG A G Sbjct: 130 QNLLI-------NRNGELKLADFGLARAFG 152
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 61.2 bits (147), Expect = 2e-09 Identities = 44/151 (29%), Positives = 70/151 (46%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V+R + GE AVK V S + L +L+ I+ ++ L +P +V+ Y+ Sbjct: 20 FGAVYRGLNIKNGETVAVKKVKLSKM---LKSDLSVIKMEIDLLKNLDHPNIVKYRGSYQ 76 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++++ C L + +PE + A Q+ Q L H +GVIHRD+K Sbjct: 77 TNDSLCIILEYCENGSLRSICK--NFGKIPENLVALYTFQVLQGLLYLHNQGVIHRDIKG 134 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 N++ D +LADFG A I A Sbjct: 135 ANILTTKDG-------TIKLADFGVATKINA 158
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 61.2 bits (147), Expect = 2e-09 Identities = 39/179 (21%), Positives = 83/179 (46%), Gaps = 10/179 (5%) Frame = +2 Query: 38 GELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRS----------NLPDDLDRE 187 G++ Y +G V C + A+K + +S N + D+ Sbjct: 49 GKIGESYFKVRKLGSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITNKIECDDKI 108 Query: 188 LAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPV 367 EI +++ L + +P ++++ V+ED + ++V + G +L + + R E Sbjct: 109 HEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRH--KFDECD 166 Query: 368 AADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGAD 544 AA+I+ Q+ + H+ ++HRD+KP+N++L E ++ ++ DFG +++ D Sbjct: 167 AANIMKQILSGICYLHKHNIVHRDIKPENILL----ENKHSLLNIKIVDFGLSSFFSKD 221
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 61.2 bits (147), Expect = 2e-09 Identities = 39/179 (21%), Positives = 83/179 (46%), Gaps = 10/179 (5%) Frame = +2 Query: 38 GELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKSVDRS----------NLPDDLDRE 187 G++ Y +G V C + A+K + +S N + D+ Sbjct: 49 GKIGESYFKVRKLGSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITNKIECDDKI 108 Query: 188 LAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPV 367 EI +++ L + +P ++++ V+ED + ++V + G +L + + R E Sbjct: 109 HEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRH--KFDECD 166 Query: 368 AADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGAD 544 AA+I+ Q+ + H+ ++HRD+KP+N++L E ++ ++ DFG +++ D Sbjct: 167 AANIMKQILSGICYLHKHNIVHRDIKPENILL----ENKHSLLNIKIVDFGLSSFFSKD 221
>ST17A_RABIT (Q9GM70) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) (rDRAK1) Length = 397 Score = 60.8 bits (146), Expect = 2e-09 Identities = 39/144 (27%), Positives = 68/144 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV +C + +G+ FA K + + D E+ E + +LA NP V+ +H VYE Sbjct: 55 FAVVRKCIQKDSGKEFAAKFMRKRRKGQDCRMEIIH-EIAVLELAQ-DNPWVINLHEVYE 112 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S +V++ +G ++ D R E ++ Q+ + + H V+H D+KP Sbjct: 113 TSSEMILVLEYAAGGEISDQCVADRDEAFNEKDVQRLMRQILEGVHFLHTHDVVHLDLKP 172 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 N++L E+ ++ DFG Sbjct: 173 QNILL----TSESPLGDIKIVDFG 192
>ST17B_RAT (Q91XS8) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 371 Score = 60.8 bits (146), Expect = 2e-09 Identities = 41/152 (26%), Positives = 76/152 (50%), Gaps = 2/152 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKSVDRSNLPDDLDRELAEIEPKLAQLAAAGN-PGVVQVHAVY 265 F VV +C S+STG+ +A K + + D AEI ++A L A + P V+ +H VY Sbjct: 44 FAVVRQCISKSTGQEYAAKFLKKRRRGQDCR---AEILHEIAVLELARSCPHVINLHEVY 100 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E + +V++ +G ++ + V E ++ Q+ + + H+ ++H D+K Sbjct: 101 ETATEIILVLEYAAGGEIFNLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLK 160 Query: 446 PDNVVL-DVDDEGENGSPRARLADFGSAAWIG 538 P N++L + G+ ++ DFG + IG Sbjct: 161 PQNILLSSIYPLGD-----IKIVDFGMSRKIG 187 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.317 0.129 0.403 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 40,364,134 Number of Sequences: 219361 Number of extensions: 715888 Number of successful extensions: 5610 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 4927 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5155 length of database: 80,573,946 effective HSP length: 106 effective length of database: 57,321,680 effective search space used: 4585734400 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
