ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | basd27k16 |
|---|---|
| Clone Library Name | barley_pub |
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 187 bits (474), Expect = 2e-47 Identities = 93/176 (52%), Positives = 125/176 (71%), Gaps = 2/176 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VY+ L D +VAVK + S QG REF E+ LLS ++H +LV L+GYC+E ++ ILVY Sbjct: 610 VYRGTLDDGQEVAVKVRSSTSTQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVY 669 Query: 186 EYMEKGTLKSHLYG--SDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 +M G+L LYG S L W R+ I +GAARGL YLHT +S+IHRDVKS+NIL Sbjct: 670 PFMSNGSLLDRLYGEASKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNIL 729 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 LD+++ AKV+DFG SK P+ ++VS V+G+ GYLDPEYY+ Q+L++KSDV+SF Sbjct: 730 LDQSMCAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSF 785
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 184 bits (468), Expect = 1e-46 Identities = 92/176 (52%), Positives = 123/176 (69%), Gaps = 2/176 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VY+ L D +VAVK + S QG REF E+ LLS ++H +LV L+GYC+E ++ ILVY Sbjct: 609 VYRGTLDDGQEVAVKVRSATSTQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVY 668 Query: 186 EYMEKGTLKSHLYGSDMPP--LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 +M G+L LYG L W R+ I +GAARGL YLHT +S+IHRDVKS+NIL Sbjct: 669 PFMSNGSLLDRLYGEPAKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNIL 728 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 LD ++ AKV+DFG SK P+ ++VS V+G+ GYLDPEYY+ Q+L++KSDV+SF Sbjct: 729 LDHSMCAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSF 784
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 174 bits (440), Expect = 2e-43 Identities = 90/179 (50%), Positives = 121/179 (67%), Gaps = 5/179 (2%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSH--QGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 V+K +L+D T VAVKR + S + +EF E++LLS L H HL++L+GYC++ +E +L Sbjct: 519 VFKGILRDGTVVAVKRAIKASDVKKSSKEFHNELDLLSRLNHAHLLNLLGYCEDGSERLL 578 Query: 180 VYEYMEKGTLKSHLYGSD---MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 VYE+M G+L HL+G D L+W +RV I + AARG+ YLH +IHRD+KS+ Sbjct: 579 VYEFMAHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSS 638 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 NIL+DE+ A+V+DFGLS GP T +S G+ GYLDPEYYR LT KSDVYSF Sbjct: 639 NILIDEDHNARVADFGLSILGPADSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSF 697
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 170 bits (431), Expect = 2e-42 Identities = 86/174 (49%), Positives = 119/174 (68%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 KVY V+ + +VAVK +++S QG +EFR E++LL + H +L SL+GYC+E N M+L+ Sbjct: 587 KVYHGVI-NGEQVAVKVLSEESAQGYKEFRAEVDLLMRVHHTNLTSLVGYCNEINHMVLI 645 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 YEYM L +L G LSW++R++I + AA+GL YLH G I+HRDVK NILL Sbjct: 646 YEYMANENLGDYLAGKRSFILSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILL 705 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 +E L AK++DFGLS++ +ST V GS GYLDPEYY +++ +KSDVYS Sbjct: 706 NEKLQAKMADFGLSRSFSVEGSGQISTVVAGSIGYLDPEYYSTRQMNEKSDVYS 759
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 164 bits (416), Expect = 1e-40 Identities = 82/163 (50%), Positives = 116/163 (71%) Frame = +3 Query: 39 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 218 VA+KR N +S QG E+R+E+ L L HR+LV L+GYC E E++LVYE+M KG+L+SH Sbjct: 121 VAIKRLNSESVQGFAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESH 180 Query: 219 LYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 398 L+ + P W R++I IGAARGL +LH+ + +I+RD K++NILLD N AK+SDFG Sbjct: 181 LFRRN-DPFPWDLRIKIVIGAARGLAFLHS-LQREVIYRDFKASNILLDSNYDAKLSDFG 238 Query: 399 LSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 L+K GP +++HV+T + G++GY PEY L KSDV++F Sbjct: 239 LAKLGPADEKSHVTTRIMGTYGYAAPEYMATGHLYVKSDVFAF 281
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 164 bits (416), Expect = 1e-40 Identities = 86/179 (48%), Positives = 120/179 (67%), Gaps = 5/179 (2%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQK--SHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 VYK L D TK+AVKR + +G EF++EI +L+ +RHRHLV+L+GYC + NE +L Sbjct: 602 VYKGELHDGTKIAVKRMENGVIAGKGFAEFKSEIAVLTKVRHRHLVTLLGYCLDGNEKLL 661 Query: 180 VYEYMEKGTLKSHLY---GSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 VYEYM +GTL HL+ + PL WK+R+ + + ARG+ YLH +S IHRD+K + Sbjct: 662 VYEYMPQGTLSRHLFEWSEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPS 721 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 NILL +++ AKV+DFGL + PE + + T + G+FGYL PEY ++T K DVYSF Sbjct: 722 NILLGDDMRAKVADFGLVRLAPE-GKGSIETRIAGTFGYLAPEYAVTGRVTTKVDVYSF 779
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 164 bits (414), Expect = 2e-40 Identities = 84/165 (50%), Positives = 113/165 (68%), Gaps = 2/165 (1%) Frame = +3 Query: 39 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 218 +AVK+ NQ QG +E+ E+ L HRHLV LIGYC E +LVYE+M +G+L++H Sbjct: 103 IAVKKLNQDGWQGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENH 162 Query: 219 LY--GSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSD 392 L+ G PLSWK R+++ +GAA+GL +LH+ + +I+RD K++NILLD AK+SD Sbjct: 163 LFRRGLYFQPLSWKLRLKVALGAAKGLAFLHSSETR-VIYRDFKTSNILLDSEYNAKLSD 221 Query: 393 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 FGL+K GP D++HVST V G+ GY PEY LT KSDVYSF Sbjct: 222 FGLAKDGPIGDKSHVSTRVMGTHGYAAPEYLATGHLTTKSDVYSF 266
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 164 bits (414), Expect = 2e-40 Identities = 85/178 (47%), Positives = 119/178 (66%), Gaps = 3/178 (1%) Frame = +3 Query: 3 KVYKAVLQDSTKV-AVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 KV+K ++ +V A+K+ ++ QG+REF E+ LS H +LV LIG+C E ++ +L Sbjct: 116 KVFKGTIEKLDQVVAIKQLDRNGVQGIREFVVEVLTLSLADHPNLVKLIGFCAEGDQRLL 175 Query: 180 VYEYMEKGTLKSHLY--GSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSAN 353 VYEYM +G+L+ HL+ S PL W R++I GAARGL YLH +I+RD+K +N Sbjct: 176 VYEYMPQGSLEDHLHVLPSGKKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSN 235 Query: 354 ILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ILL E+ K+SDFGL+K GP D+THVST V G++GY P+Y +LT KSD+YSF Sbjct: 236 ILLGEDYQPKLSDFGLAKVGPSGDKTHVSTRVMGTYGYCAPDYAMTGQLTFKSDIYSF 293
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 163 bits (413), Expect = 2e-40 Identities = 89/180 (49%), Positives = 122/180 (67%), Gaps = 5/180 (2%) Frame = +3 Query: 3 KVYKAVLQDSTKV-AVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 +VYK L + +V AVK+ ++ QG REF E+ +LS L H +LV+LIGYC + ++ +L Sbjct: 99 RVYKGRLDSTGQVVAVKQLDRNGLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLL 158 Query: 180 VYEYMEKGTLKSHLYGSDMPP----LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 VYE+M G+L+ HL+ D+PP L W R++I GAA+GL +LH +I+RD KS Sbjct: 159 VYEFMPLGSLEDHLH--DLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKS 216 Query: 348 ANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +NILLDE K+SDFGL+K GP D++HVST V G++GY PEY +LT KSDVYSF Sbjct: 217 SNILLDEGFHPKLSDFGLAKLGPTGDKSHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYSF 276
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 162 bits (410), Expect = 5e-40 Identities = 86/165 (52%), Positives = 112/165 (67%), Gaps = 2/165 (1%) Frame = +3 Query: 39 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 218 +AVKR NQ+ QG RE+ EI L L H +LV LIGYC E+ +LVYE+M +G+L++H Sbjct: 103 IAVKRLNQEGFQGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENH 162 Query: 219 LY--GSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSD 392 L+ G+ PLSW RV + +GAARGL +LH +I+RD K++NILLD N AK+SD Sbjct: 163 LFRRGTFYQPLSWNTRVRMALGAARGLAFLHNA-QPQVIYRDFKASNILLDSNYNAKLSD 221 Query: 393 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 FGL++ GP D +HVST V G+ GY PEY L+ KSDVYSF Sbjct: 222 FGLARDGPMGDNSHVSTRVMGTQGYAAPEYLATGHLSVKSDVYSF 266
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 160 bits (406), Expect = 2e-39 Identities = 85/176 (48%), Positives = 114/176 (64%), Gaps = 2/176 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYKA L VAVK+ ++ QG REF E+E L ++H +LVSL+GYC E +LVY Sbjct: 931 VYKACLPGEKTVAVKKLSEAKTQGNREFMAEMETLGKVKHPNLVSLLGYCSFSEEKLLVY 990 Query: 186 EYMEKGTLKSHLYGSD--MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 EYM G+L L + L W KR++I +GAARGL +LH GF IIHRD+K++NIL Sbjct: 991 EYMVNGSLDHWLRNQTGMLEVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNIL 1050 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 LD + KV+DFGL++ ++HVST + G+FGY+ PEY + + T K DVYSF Sbjct: 1051 LDGDFEPKVADFGLARL-ISACESHVSTVIAGTFGYIPPEYGQSARATTKGDVYSF 1105
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 160 bits (404), Expect = 3e-39 Identities = 81/165 (49%), Positives = 112/165 (67%), Gaps = 2/165 (1%) Frame = +3 Query: 39 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 218 +AVK+ NQ QG +E+ E+ L H +LV LIGYC E +LVYE+M +G+L++H Sbjct: 104 IAVKKLNQDGWQGHQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENH 163 Query: 219 LY--GSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSD 392 L+ GS PLSW R+++ +GAA+GL +LH S+I+RD K++NILLD AK+SD Sbjct: 164 LFRRGSYFQPLSWTLRLKVALGAAKGLAFLHNA-ETSVIYRDFKTSNILLDSEYNAKLSD 222 Query: 393 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 FGL+K GP D++HVST + G++GY PEY LT KSDVYS+ Sbjct: 223 FGLAKDGPTGDKSHVSTRIMGTYGYAAPEYLATGHLTTKSDVYSY 267
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 155 bits (392), Expect = 6e-38 Identities = 82/177 (46%), Positives = 122/177 (68%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYKA+L+D + VA+K+ S QG REF E+E + ++HR+LV L+GYC +E +LVY Sbjct: 897 VYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVY 956 Query: 186 EYMEKGTLKSHLYGSDMP--PLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 E+M+ G+L+ L+ L+W R +I IG+ARGL +LH + IIHRD+KS+N+L Sbjct: 957 EFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVL 1016 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVS-TAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 LDENL A+VSDFG+++ +D TH+S + + G+ GY+ PEYY+ + + K DVYS+ Sbjct: 1017 LDENLEARVSDFGMARLMSAMD-THLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSY 1072
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 154 bits (390), Expect = 1e-37 Identities = 84/176 (47%), Positives = 115/176 (65%), Gaps = 2/176 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYKA L D TKVA+KR + + Q REF+ E+E LS +H +LV L+GYC+ +N+ +L+Y Sbjct: 757 VYKATLPDGTKVAIKRLSGDTGQMDREFQAEVETLSRAQHPNLVHLLGYCNYKNDKLLIY 816 Query: 186 EYMEKGTLKSHLYGS-DMPP-LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 YM+ G+L L+ D PP L WK R+ I GAA GL YLH I+HRD+KS+NIL Sbjct: 817 SYMDNGSLDYWLHEKVDGPPSLDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSNIL 876 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 L + +A ++DFGL++ D THV+T + G+ GY+ PEY + T K DVYSF Sbjct: 877 LSDTFVAHLADFGLARLILPYD-THVTTDLVGTLGYIPPEYGQASVATYKGDVYSF 931
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 154 bits (389), Expect = 1e-37 Identities = 84/177 (47%), Positives = 119/177 (67%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYKA L+D + VA+K+ S QG REF E+E + ++HR+LV L+GYC E +LVY Sbjct: 902 VYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVY 961 Query: 186 EYMEKGTLKSHLYGSDMP--PLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 EYM+ G+L+ L+ L+W R +I IGAARGL +LH IIHRD+KS+N+L Sbjct: 962 EYMKYGSLEDVLHDRKKTGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVL 1021 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVS-TAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 LDENL A+VSDFG+++ +D TH+S + + G+ GY+ PEYY+ + + K DVYS+ Sbjct: 1022 LDENLEARVSDFGMARLMSAMD-THLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSY 1077
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 153 bits (387), Expect = 2e-37 Identities = 84/177 (47%), Positives = 119/177 (67%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYKA L+D + VA+K+ S QG REF E+E + ++HR+LV L+GYC E +LVY Sbjct: 902 VYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVY 961 Query: 186 EYMEKGTLKSHLYGSDMP--PLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 EYM+ G+L+ L+ L+W R +I IGAARGL +LH IIHRD+KS+N+L Sbjct: 962 EYMKYGSLEDVLHDRKKIGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVL 1021 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVS-TAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 LDENL A+VSDFG+++ +D TH+S + + G+ GY+ PEYY+ + + K DVYS+ Sbjct: 1022 LDENLEARVSDFGMARLMSAMD-THLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSY 1077
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 152 bits (384), Expect = 5e-37 Identities = 83/178 (46%), Positives = 119/178 (66%), Gaps = 4/178 (2%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYKA L D + VA+K+ Q + QG REF E+E + ++HR+LV L+GYC E +LVY Sbjct: 872 VYKAKLADGSVVAIKKLIQVTGQGDREFMAEMETIGKIKHRNLVPLLGYCKIGEERLLVY 931 Query: 186 EYMEKGTLKSHLYGSDMPP---LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANI 356 EYM+ G+L++ L+ L W R +I IGAARGL +LH IIHRD+KS+N+ Sbjct: 932 EYMKYGSLETVLHEKTKKGGIFLDWSARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNV 991 Query: 357 LLDENLMAKVSDFGLSKTGPELDQTHVS-TAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 LLD++ +A+VSDFG+++ LD TH+S + + G+ GY+ PEYY+ + T K DVYS+ Sbjct: 992 LLDQDFVARVSDFGMARLVSALD-THLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSY 1048
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 152 bits (383), Expect = 7e-37 Identities = 83/180 (46%), Positives = 121/180 (67%), Gaps = 5/180 (2%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +VYKA L+D + VA+K+ + + QG REF E+E + ++HR+LV L+GYC E +LV Sbjct: 872 EVYKAQLRDGSVVAIKKLIRITGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGEERLLV 931 Query: 183 YEYMEKGTLKSHLYGSDMPP----LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 YEYM+ G+L++ L+ L+W R +I IGAARGL +LH IIHRD+KS+ Sbjct: 932 YEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSS 991 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVS-TAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 N+LLDE+ A+VSDFG+++ LD TH+S + + G+ GY+ PEYY+ + T K DVYS+ Sbjct: 992 NVLLDEDFEARVSDFGMARLVSALD-THLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSY 1050
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 152 bits (383), Expect = 7e-37 Identities = 85/178 (47%), Positives = 113/178 (63%), Gaps = 3/178 (1%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 KVYK L D T VAVKR ++ QG +F+TE+E++S HR+L+ L G+C E +L Sbjct: 302 KVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLL 361 Query: 180 VYEYMEKGTLKSHLYG--SDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSAN 353 VY YM G++ S L PPL W KR I +G+ARGL YLH IIHRDVK+AN Sbjct: 362 VYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAAN 421 Query: 354 ILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ILLDE A V DFGL+K + THV+TAV+G+ G++ PEY K ++K+DV+ + Sbjct: 422 ILLDEEFEAVVGDFGLAKL-MDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGY 478
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 150 bits (380), Expect = 2e-36 Identities = 83/176 (47%), Positives = 112/176 (63%), Gaps = 2/176 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYKA L D KVA+K+ + Q REF E+E LS +H +LV L G+C +N+ +L+Y Sbjct: 748 VYKATLPDGKKVAIKKLSGDCGQIEREFEAEVETLSRAQHPNLVLLRGFCFYKNDRLLIY 807 Query: 186 EYMEKGTLKSHLYGSDMPP--LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 YME G+L L+ + P L WK R+ I GAA+GL YLH G I+HRD+KS+NIL Sbjct: 808 SYMENGSLDYWLHERNDGPALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNIL 867 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 LDEN + ++DFGL++ +THVST + G+ GY+ PEY + T K DVYSF Sbjct: 868 LDENFNSHLADFGLARLMSPY-ETHVSTDLVGTLGYIPPEYGQASVATYKGDVYSF 922
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 149 bits (375), Expect = 6e-36 Identities = 81/179 (45%), Positives = 121/179 (67%), Gaps = 5/179 (2%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+KA L+D + VA+K+ + S QG REF E+E L ++HR+LV L+GYC E +LV Sbjct: 851 EVFKATLKDGSSVAIKKLIRLSCQGDREFMAEMETLGKIKHRNLVPLLGYCKIGEERLLV 910 Query: 183 YEYMEKGTLKSHLYGSDMPP----LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 YE+M+ G+L+ L+G L W++R +I GAA+GL +LH IIHRD+KS+ Sbjct: 911 YEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSS 970 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVS-TAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 N+LLD+++ A+VSDFG+++ LD TH+S + + G+ GY+ PEYY+ + T K DVYS Sbjct: 971 NVLLDQDMEARVSDFGMARLISALD-THLSVSTLAGTPGYVPPEYYQSFRCTAKGDVYS 1028
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 145 bits (366), Expect = 7e-35 Identities = 79/176 (44%), Positives = 117/176 (66%), Gaps = 2/176 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK L D ++AVKR ++ S QG EF E+ L++ L+H +LV ++G C E +E +L+Y Sbjct: 542 VYKGRLLDGKEIAVKRLSKTSVQGTDEFMNEVTLIARLQHINLVQVLGCCIEGDEKMLIY 601 Query: 186 EYMEKGTLKSHLYGSDM-PPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EY+E +L S+L+G L+W +R +I G ARGL YLH IIHRD+K +NILL Sbjct: 602 EYLENLSLDSYLFGKTRRSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNILL 661 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVST-AVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 D+N++ K+SDFG+++ E D+T +T V G++GY+ PEY ++KSDV+SF Sbjct: 662 DKNMIPKISDFGMARIF-ERDETEANTMKVVGTYGYMSPEYAMYGIFSEKSDVFSF 716
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 137 bits (345), Expect = 2e-32 Identities = 75/178 (42%), Positives = 109/178 (61%), Gaps = 4/178 (2%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKR----GNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEM 173 VY+ + ++ VA+KR G +S G F EI+ L +RHRH+V L+GY ++ Sbjct: 706 VYRGSMPNNVDVAIKRLVGRGTGRSDHG---FTAEIQTLGRIRHRHIVRLLGYVANKDTN 762 Query: 174 ILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSAN 353 +L+YEYM G+L L+GS L W+ R + + AA+GL YLH + I+HRDVKS N Sbjct: 763 LLLYEYMPNGSLGELLHGSKGGHLQWETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNN 822 Query: 354 ILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ILLD + A V+DFGL+K + + +++ GS+GY+ PEY K+ +KSDVYSF Sbjct: 823 ILLDSDFEAHVADFGLAKFLVDGAASECMSSIAGSYGYIAPEYAYTLKVDEKSDVYSF 880
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 124 bits (310), Expect = 2e-28 Identities = 75/189 (39%), Positives = 102/189 (53%), Gaps = 14/189 (7%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLRE----------FRTEIELLSGLRHRHLVSLIGY 152 KVYK L+ VAVK+ N+ G E F E+E L +RH+ +V L Sbjct: 696 KVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAEVETLGTIRHKSIVRLWCC 755 Query: 153 CDEQNEMILVYEYMEKGTLKSHLYGSDMPP--LSWKKRVEICIGAARGLHYLHTGFAKSI 326 C + +LVYEYM G+L L+G L W +R+ I + AA GL YLH I Sbjct: 756 CSSGDCKLLVYEYMPNGSLADVLHGDRKGGVVLGWPERLRIALDAAEGLSYLHHDCVPPI 815 Query: 327 IHRDVKSANILLDENLMAKVSDFGLSKTGPELDQ--THVSTAVKGSFGYLDPEYYRRQKL 500 +HRDVKS+NILLD + AKV+DFG++K G + + GS GY+ PEY ++ Sbjct: 816 VHRDVKSSNILLDSDYGAKVADFGIAKVGQMSGSKTPEAMSGIAGSCGYIAPEYVYTLRV 875 Query: 501 TDKSDVYSF 527 +KSD+YSF Sbjct: 876 NEKSDIYSF 884
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 123 bits (308), Expect = 4e-28 Identities = 72/179 (40%), Positives = 112/179 (62%), Gaps = 5/179 (2%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKR----GNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEM 173 VYK + ++T VAVK+ + + + ++F EI++++ +H +LV L+G+ + +++ Sbjct: 200 VYKGYVNNTT-VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDL 258 Query: 174 ILVYEYMEKGTLKSHLYGSD-MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 LVY YM G+L L D PPLSW R +I GAA G+++LH IHRD+KSA Sbjct: 259 CLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH---IHRDIKSA 315 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 NILLDE AK+SDFGL++ + QT +++ + G+ Y+ PE R + +T KSD+YSF Sbjct: 316 NILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSF 373
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 121 bits (303), Expect = 1e-27 Identities = 70/179 (39%), Positives = 109/179 (60%), Gaps = 5/179 (2%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQ----KSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEM 173 VYK + ++T VAVK+ + + ++F EI++++ +H +LV L+G+ + + + Sbjct: 200 VYKGCV-NNTIVAVKKLGAMVEISTEELKQQFDQEIKVMATCQHENLVELLGFSSDSDNL 258 Query: 174 ILVYEYMEKGTLKSHLYGSD-MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 LVY YM G+L L D PPLSW R ++ G A G+ +LH IHRD+KSA Sbjct: 259 CLVYAYMPNGSLLDRLSCLDGTPPLSWHTRCKVAQGTANGIRFLHENHH---IHRDIKSA 315 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 NILLD++ AK+SDFGL++ L QT +++ + G+ Y+ PE R + +T KSD+YSF Sbjct: 316 NILLDKDFTAKISDFGLARASARLAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSF 373
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 120 bits (301), Expect = 2e-27 Identities = 69/176 (39%), Positives = 103/176 (58%), Gaps = 2/176 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK VL+D VAVK+ + QG F+ E+ ++ + H +LV + G+C E + +LV Sbjct: 548 VYKGVLEDDRHVAVKK-LENVRQGKEVFQAELSVIGRINHMNLVRIWGFCSEGSHRLLVS 606 Query: 186 EYMEKGTLKSHLY--GSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 EY+E G+L + L+ G ++ L W+ R I +G A+GL YLH + +IH DVK NIL Sbjct: 607 EYVENGSLANILFSEGGNIL-LDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENIL 665 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 LD+ K++DFGL K T + V+G+ GY+ PE+ +T K DVYS+ Sbjct: 666 LDQAFEPKITDFGLVKLLNRGGSTQNVSHVRGTLGYIAPEWVSSLPITAKVDVYSY 721
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 118 bits (296), Expect = 9e-27 Identities = 70/187 (37%), Positives = 110/187 (58%), Gaps = 13/187 (6%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSH----QGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEM 173 VY+AV++++T AVKR +++ + F TE+E LS RH ++V GYC E Sbjct: 226 VYRAVMRNTT-YAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGLY 284 Query: 174 ILVYEYMEKGTLKS--HLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 LVY ++ G+L+ HL PLSW +R++I +G AR + +LH + S+IH D+KS Sbjct: 285 CLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQD-SPSLIHGDIKS 343 Query: 348 ANILLDENLMAKVSDFGLSK----TGPELDQTHV---STAVKGSFGYLDPEYYRRQKLTD 506 +N+LLDE LM K+ DFGL++ G + Q+ ++ V+G+ YL EY + +L Sbjct: 344 SNVLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYLPEEYIKTGRLAV 403 Query: 507 KSDVYSF 527 +D +SF Sbjct: 404 DTDTFSF 410
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 113 bits (282), Expect = 4e-25 Identities = 68/187 (36%), Positives = 107/187 (57%), Gaps = 13/187 (6%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGL----REFRTEIELLSGLRHRHLVSLIGYCDEQNEM 173 VY+AV+++ T AVKR + + + F TE+E LS RH ++V GYC + Sbjct: 226 VYRAVMRN-TVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFY 284 Query: 174 ILVYEYMEKGTLKSHLYGSDM--PPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 LVY ++ G+L+ L+ PPLSW +R++I +G AR + +LH + S+IH D+KS Sbjct: 285 CLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQD-SPSLIHGDIKS 343 Query: 348 ANILLDENLMAKVSDFGLSK----TGPELDQTHV---STAVKGSFGYLDPEYYRRQKLTD 506 +N+LLDE L K+ DFGL++ G Q+ + + V+G+ YL EY + +L Sbjct: 344 SNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAV 403 Query: 507 KSDVYSF 527 +D +SF Sbjct: 404 DTDTFSF 410
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 110 bits (275), Expect = 2e-24 Identities = 59/155 (38%), Positives = 96/155 (61%), Gaps = 5/155 (3%) Frame = +3 Query: 78 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL----KSHLYGSDMPPL 245 L++ E++ L+ +RH ++++L GY + + LVY+ M+ G+L ++H + +P L Sbjct: 256 LQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPAL 315 Query: 246 SWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPE-L 422 +W++R I +G ARG+++LHT +IH D+K ANILLD+ L K+ DFGL + GP+ L Sbjct: 316 TWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSL 375 Query: 423 DQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 D V G+ YL PE+ ++L+ DVYSF Sbjct: 376 DAVVEVNKVFGTKIYLPPEFRNFRQLSTGVDVYSF 410
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 106 bits (265), Expect = 3e-23 Identities = 64/176 (36%), Positives = 95/176 (53%), Gaps = 2/176 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKS-HQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +YKA L AVK+ G EIE + +RHR+L+ L + + +++ Sbjct: 830 IYKATLSPDKVYAVKKLVFTGIKNGSVSMVREIETIGKVRHRNLIKLEEFWLRKEYGLIL 889 Query: 183 YEYMEKGTLKSHLYGSDMP-PLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 Y YME G+L L+ ++ P PL W R I +G A GL YLH +I+HRD+K NIL Sbjct: 890 YTYMENGSLHDILHETNPPKPLDWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPMNIL 949 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 LD +L +SDFG++K + + S V+G+ GY+ PE + +SDVYS+ Sbjct: 950 LDSDLEPHISDFGIAKLLDQSATSIPSNTVQGTIGYMAPENAFTTVKSRESDVYSY 1005
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 105 bits (261), Expect = 1e-22 Identities = 65/184 (35%), Positives = 101/184 (54%), Gaps = 9/184 (4%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLRE----FRTEIELLSGLRHRHLVSLIGYCDEQNE 170 +VY+ +++ AVK Q+ L++ F +E+E+L RH H++ L Y E + Sbjct: 191 EVYRVDIRNQA-YAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEK 249 Query: 171 MILVYEYMEKGTLKSHLYGSD-MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 + LVY YM GTL L ++ PLSW R+ + IG A+ + YLH ++I +V S Sbjct: 250 LCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSS 309 Query: 348 ANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGS----FGYLDPEYYRRQKLTDKSD 515 ANILLD+ L K++DF + P L+Q + + G Y+ EY R+ +L+ K+D Sbjct: 310 ANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTD 369 Query: 516 VYSF 527 VYSF Sbjct: 370 VYSF 373
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 101 bits (251), Expect = 1e-21 Identities = 61/177 (34%), Positives = 99/177 (55%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIG-YCDEQNEMILV 182 VYKA L D +A++ + + + I L +RH +LV L Y ++ E +L+ Sbjct: 387 VYKAKLSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRAFYQGKRGEKLLI 446 Query: 183 YEYMEKGTLKSHLYGSD--MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANI 356 Y+Y+ +L L+ S P L+W +R +I +G ARGL YLHTG IIH +++S N+ Sbjct: 447 YDYLPNISLHDLLHESKPRKPALNWARRHKIALGIARGLAYLHTGQEVPIIHGNIRSKNV 506 Query: 357 LLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 L+D+ A++++FGL K + + + K S GY PE ++ +K +SDVY+F Sbjct: 507 LVDDFFFARLTEFGLDKIMVQAVADEIVSQAK-SDGYKAPELHKMKKCNPRSDVYAF 562
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 99.0 bits (245), Expect = 7e-21 Identities = 58/165 (35%), Positives = 98/165 (59%), Gaps = 2/165 (1%) Frame = +3 Query: 39 VAVKR--GNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 212 VAVK+ + S L EFR E+ LS L+H ++V+ IG C ++ + +V EYM G L+ Sbjct: 1388 VAVKKFVKQKLSETQLLEFRAEMAFLSELKHSNIVTFIGACIKKPNICIVTEYMRMGNLR 1447 Query: 213 SHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSD 392 L D+ +++ ++++ GAA G+ YLH+ I+HRD+K ANIL+DE+ K++D Sbjct: 1448 DVLKNPDI-KITFANKLKLLYGAAMGIDYLHSS-NPMIVHRDIKPANILVDEHFNVKIAD 1505 Query: 393 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 FG ++ + + + + G+ + PE R +K +K+DV+SF Sbjct: 1506 FGFAR----IKEDNTTMTRCGTPCWTAPEVIRGEKYCEKADVFSF 1546 Score = 98.2 bits (243), Expect = 1e-20 Identities = 60/179 (33%), Positives = 101/179 (56%), Gaps = 4/179 (2%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQK--SHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMI 176 +VYK++ + T+VAVK + K S R F E+++++ LRH ++V + + M Sbjct: 799 EVYKSIWK-GTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAASTKSPNMC 857 Query: 177 LVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANI 356 +V E+M G+L L +P + + ++++ A++G+H+LH+ I+HRD+KS N+ Sbjct: 858 IVMEFMSLGSLYDLLGNELIPEIPYALKIKMAYQASKGMHFLHSS---GIVHRDLKSLNL 914 Query: 357 LLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTD--KSDVYSF 527 LLD KVSDFGL+K ELD+ + + G+ ++ PE D +DVYSF Sbjct: 915 LLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIAPEILNDSTEVDYILADVYSF 973
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 96.7 bits (239), Expect = 4e-20 Identities = 61/184 (33%), Positives = 97/184 (52%), Gaps = 9/184 (4%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLRE----FRTEIELLSGLRHRHLVSLIGYCDEQNE 170 +VY+ +Q+ T AVK Q+ ++ F +E+E+L H +++ L Y E + Sbjct: 178 EVYRVEIQNLT-YAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEK 236 Query: 171 MILVYEYMEKGTLKSHLYG-SDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 L+Y YM GTL L D PL W R+ I IG ++ +HYLH S+I + S Sbjct: 237 FCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISS 296 Query: 348 ANILLDENLMAKVSDFGLSKTGPELDQ----THVSTAVKGSFGYLDPEYYRRQKLTDKSD 515 ANILLD+ K++DF ++ L+ +++++ Y+ EY R+ KL+ K+D Sbjct: 297 ANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTD 356 Query: 516 VYSF 527 VYSF Sbjct: 357 VYSF 360
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 92.4 bits (228), Expect = 7e-19 Identities = 60/178 (33%), Positives = 90/178 (50%), Gaps = 11/178 (6%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 QD VAVK S ++F E ELL+ L+H H+V G C E + +I+V+EYM+ G Sbjct: 564 QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 623 Query: 204 TLKSHL--YGSDM-------PP--LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 L L +G D PP L+ + + I A G+ YL ++ +HRD+ + Sbjct: 624 DLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATR 680 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 N L+ ENL+ K+ DFG+S+ D V ++ PE +K T +SDV+S Sbjct: 681 NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWS 738
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 92.4 bits (228), Expect = 7e-19 Identities = 60/178 (33%), Positives = 90/178 (50%), Gaps = 11/178 (6%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 QD VAVK S ++F E ELL+ L+H H+V G C E + +I+V+EYM+ G Sbjct: 563 QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 622 Query: 204 TLKSHL--YGSDM-------PP--LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 L L +G D PP L+ + + I A G+ YL ++ +HRD+ + Sbjct: 623 DLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATR 679 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 N L+ ENL+ K+ DFG+S+ D V ++ PE +K T +SDV+S Sbjct: 680 NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWS 737
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 92.4 bits (228), Expect = 7e-19 Identities = 60/178 (33%), Positives = 90/178 (50%), Gaps = 11/178 (6%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 QD VAVK S ++F E ELL+ L+H H+V G C E + +I+V+EYM+ G Sbjct: 563 QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 622 Query: 204 TLKSHL--YGSDM-------PP--LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 L L +G D PP L+ + + I A G+ YL ++ +HRD+ + Sbjct: 623 DLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATR 679 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 N L+ ENL+ K+ DFG+S+ D V ++ PE +K T +SDV+S Sbjct: 680 NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWS 737
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 91.3 bits (225), Expect = 1e-18 Identities = 62/180 (34%), Positives = 96/180 (53%), Gaps = 5/180 (2%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +VYK + S +V V + N+ R E++L++ LRH +++ +G C Q ++ + Sbjct: 65 EVYKVRHRQSGQVMVLKMNKLPSNRSNTLR-EVQLMNRLRHPNILRFMGVCVHQGQLHAL 123 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM GTL+ L S PLSW R+ + + A+GL YLH AK + HRD+ S N L+ Sbjct: 124 TEYMNGGTLEQLL--SSPEPLSWPVRLHLALDIAQGLRYLH---AKGVFHRDLTSKNCLV 178 Query: 363 ---DENLMAKVSDFGLSKTGPELDQ--THVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 D A V DFGL++ P + AV GS ++ PE R + +K+DV++F Sbjct: 179 RREDRGFTAVVGDFGLAEKIPVYREGTRKEPLAVVGSPYWMAPEVLRGELYDEKADVFAF 238
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 90.9 bits (224), Expect = 2e-18 Identities = 62/180 (34%), Positives = 96/180 (53%), Gaps = 5/180 (2%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +VYK + S +V V + N+ R E++L++ LRH +++ +G C Q ++ + Sbjct: 70 EVYKVRHRQSGQVMVLKMNKLPSNRGNTLR-EVQLMNRLRHPNILRFMGVCVHQGQLHAL 128 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM GTL+ L S PLSW R+ + + ARGL YLH +K + HRD+ S N L+ Sbjct: 129 TEYMNGGTLEQLL--SSPEPLSWPVRLHLALDIARGLRYLH---SKGVFHRDLTSKNCLV 183 Query: 363 ---DENLMAKVSDFGLSKTGPELDQ--THVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 D A V DFGL++ P + AV GS ++ PE R + +K+DV++F Sbjct: 184 RREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAF 243
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 90.5 bits (223), Expect = 3e-18 Identities = 57/178 (32%), Positives = 87/178 (48%), Gaps = 11/178 (6%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 QD VAVK S ++F E ELL+ L+H H+V G C E + +I+V+EYM+ G Sbjct: 560 QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 619 Query: 204 TLKSHL-----------YGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 L L G+ L+ + + I A G+ YL ++ +HRD+ + Sbjct: 620 DLNKFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATR 676 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 N L+ ENL+ K+ DFG+S+ D V ++ PE +K T +SDV+S Sbjct: 677 NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWS 734
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 90.5 bits (223), Expect = 3e-18 Identities = 62/180 (34%), Positives = 96/180 (53%), Gaps = 5/180 (2%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +VYK + S +V V + N+ R E++L++ LRH +++ +G C Q ++ + Sbjct: 65 EVYKVRHRQSGQVMVLKMNKLPSNRSNTLR-EVQLMNRLRHPNILRFMGVCVHQGQLHAL 123 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM GTL+ L S PLSW R+ + + A+GL YLH AK + HRD+ S N L+ Sbjct: 124 TEYMNGGTLEQLL--SSPEPLSWPVRLHLALDIAQGLRYLH---AKGVFHRDLTSKNCLV 178 Query: 363 ---DENLMAKVSDFGLSKTGPELDQ--THVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 D A V DFGL++ P + AV GS ++ PE R + +K+DV++F Sbjct: 179 RREDGGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAF 238
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 89.4 bits (220), Expect = 6e-18 Identities = 55/181 (30%), Positives = 98/181 (54%), Gaps = 6/181 (3%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGL------REFRTEIELLSGLRHRHLVSLIGYCDEQ 164 ++Y+ + + VAVK +H+ ++F++E+ LLS L H ++V I C + Sbjct: 99 RIYRGIYKQRA-VAVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNIVQFIAACKKP 157 Query: 165 NEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 ++ EYM +G L+ +L + LS + + + + +RG+ YLH ++ +IHRD+K Sbjct: 158 PVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLH---SQGVIHRDLK 214 Query: 345 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 S N+LL++ + KV+DFG S Q + G++ ++ PE + + T K DVYS Sbjct: 215 SNNLLLNDEMRVKVADFGTSCLE---TQCREAKGNMGTYRWMAPEMIKEKPYTRKVDVYS 271 Query: 525 F 527 F Sbjct: 272 F 272
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 87.0 bits (214), Expect = 3e-17 Identities = 56/181 (30%), Positives = 87/181 (48%), Gaps = 13/181 (7%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 QD VAVK + S ++F+ E ELL+ L+H+H+V G C E +++V+EYM G Sbjct: 536 QDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHG 595 Query: 204 TLKSHL--YGSDMP-----------PLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 L L +G D PL + + + A G+ YL +HRD+ Sbjct: 596 DLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYL---AGLHFVHRDLA 652 Query: 345 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + N L+ + L+ K+ DFG+S+ D V ++ PE +K T +SDV+S Sbjct: 653 TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWS 712 Query: 525 F 527 F Sbjct: 713 F 713
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 86.7 bits (213), Expect = 4e-17 Identities = 57/175 (32%), Positives = 96/175 (54%), Gaps = 1/175 (0%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 V KA Q+ ++AVK + + EI LS + H +++ +IG + L+ Sbjct: 25 VRKATFQNQ-EIAVKIFDFLEETIKKNAEREITHLSEIDHENVIRVIGRASNGKKDYLLM 83 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL- 362 EY+E+G+L ++LYG D + ++ V + A+ L YLH+ + I+HRD+K N+LL Sbjct: 84 EYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHS-LDRPIVHRDIKPQNMLLY 142 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +++ K+ DFGL+ D ++ T ++G+ Y+ PE + K T K DVYSF Sbjct: 143 NQHEDLKICDFGLA-----TDMSNNKTDMQGTLRYMAPEAIKHLKYTAKCDVYSF 192
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 86.7 bits (213), Expect = 4e-17 Identities = 62/184 (33%), Positives = 96/184 (52%), Gaps = 19/184 (10%) Frame = +3 Query: 33 TKVAVK---RGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNE--MILVYEYME 197 T VA+K R K+ L F+ E+ +LS LRH ++V +G C E +V E+M Sbjct: 1311 TDVAIKIIYRDQFKTKSSLVMFQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMG 1370 Query: 198 KGTLKSHLYGS-DMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDEN- 371 G+L+ L ++ + R+++ + A+G++YLH G+ I+HRD+ S NILLD N Sbjct: 1371 GGSLRQFLTDHFNLLEQNPHIRLKLALDIAKGMNYLH-GWTPPILHRDLSSRNILLDHNI 1429 Query: 372 ------------LMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSD 515 + K+SDFGLS+ E Q T G Y+ PE ++ ++KSD Sbjct: 1430 DPKNPVVSSRQDIKCKISDFGLSRLKKE--QASQMTQSVGCIPYMAPEVFKGDSNSEKSD 1487 Query: 516 VYSF 527 VYS+ Sbjct: 1488 VYSY 1491
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 85.5 bits (210), Expect = 8e-17 Identities = 54/181 (29%), Positives = 87/181 (48%), Gaps = 13/181 (7%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 Q+ T VAVK + + +F+ E ELL+ L+H H+V G C E + +I+V+EYM+ G Sbjct: 519 QEKTLVAVKALKEVTENARLDFQREAELLTVLQHEHIVKFYGVCTEGDPLIMVFEYMKHG 578 Query: 204 TLKSHL-------------YGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 L L G L+ ++I A G+ YL + +HRD+ Sbjct: 579 DLNRFLRSHGPDAKILDQGQGQPCGQLTLSHMLQIATQIASGMVYL---ASLHFVHRDLA 635 Query: 345 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + N L+ +L+ K+ DFG+S+ D V ++ PE +K T +SD++S Sbjct: 636 TRNCLVGHDLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDIWS 695 Query: 525 F 527 F Sbjct: 696 F 696
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 85.5 bits (210), Expect = 8e-17 Identities = 55/181 (30%), Positives = 87/181 (48%), Gaps = 13/181 (7%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 QD VAVK + S ++F E ELL+ L+H+H+V G C E +++V+EYM G Sbjct: 539 QDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHG 598 Query: 204 TLKSHL--YGSDMP-----------PLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 L L +G D PL + + + A G+ YL + +HRD+ Sbjct: 599 DLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYL---ASLHFVHRDLA 655 Query: 345 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + N L+ + L+ K+ DFG+S+ D V ++ PE +K + +SDV+S Sbjct: 656 TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWS 715 Query: 525 F 527 F Sbjct: 716 F 716
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 85.1 bits (209), Expect = 1e-16 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 14/182 (7%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 +D VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 204 TLKSHL--YGSD------------MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDV 341 L L +G D L + + I A G+ YL ++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 342 KSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 + N L+ NL+ K+ DFG+S+ D V ++ PE +K T +SDV+ Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW 740 Query: 522 SF 527 SF Sbjct: 741 SF 742
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 85.1 bits (209), Expect = 1e-16 Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 14/182 (7%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 +D VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 204 TLKSHL--YGSD------------MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDV 341 L L +G D L + + I A G+ YL ++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 342 KSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 + N L+ NL+ K+ DFG+S+ D V ++ PE +K T +SDV+ Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW 740 Query: 522 SF 527 SF Sbjct: 741 SF 742
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 84.7 bits (208), Expect = 1e-16 Identities = 51/151 (33%), Positives = 84/151 (55%), Gaps = 1/151 (0%) Frame = +3 Query: 78 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDM-PPLSWK 254 + EF E+ ++ LRH ++V +G + + +V EY+ +G+L L+ S L + Sbjct: 590 VNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDER 649 Query: 255 KRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTH 434 +R+ + A+G++YLH I+HRD+KS N+L+D+ KV DFGLS+ + Sbjct: 650 RRLSMAYDVAKGMNYLHNR-NPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSS 708 Query: 435 VSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 S A G+ ++ PE R + +KSDVYSF Sbjct: 709 KSAA--GTPEWMAPEVLRDEPSNEKSDVYSF 737
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 84.7 bits (208), Expect = 1e-16 Identities = 55/181 (30%), Positives = 87/181 (48%), Gaps = 14/181 (7%) Frame = +3 Query: 27 DSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 206 D VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G Sbjct: 567 DKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGD 626 Query: 207 LKSHL--YGSD------------MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 L L +G D L + + I A G+ YL ++ +HRD+ Sbjct: 627 LNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLA 683 Query: 345 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + N L+ NL+ K+ DFG+S+ D V ++ PE +K T +SDV+S Sbjct: 684 TRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWS 743 Query: 525 F 527 F Sbjct: 744 F 744
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 84.3 bits (207), Expect = 2e-16 Identities = 57/164 (34%), Positives = 86/164 (52%) Frame = +3 Query: 36 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 215 KVA+K Q+ +F E E++ L H LV L G C EQ + LV+E+ME G L Sbjct: 392 KVAIKT-IQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSD 450 Query: 216 HLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDF 395 +L S + + + +C+ G+ YL +IHRD+ + N L+ EN + KVSDF Sbjct: 451 YL-RSQRGLFAAETLLGMCLDVCEGMAYLEKA---CVIHRDLAARNCLVGENQVIKVSDF 506 Query: 396 GLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 G+++ + DQ ST K + PE + + + KSDV+SF Sbjct: 507 GMTRFVLD-DQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSF 549
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 84.3 bits (207), Expect = 2e-16 Identities = 57/175 (32%), Positives = 91/175 (52%), Gaps = 1/175 (0%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 V KAV +D VAVK + Q ++ E++ LS ++H ++++L G Q L+ Sbjct: 33 VCKAVWRDKL-VAVKEFFASAEQ--KDIEKEVKQLSRVKHPNIIALHGISSYQQATYLIM 89 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL- 362 E+ E G+L + L+G P S + A GL YLH K +IHRDVK N+LL Sbjct: 90 EFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLT 149 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ++ K+ DF G D++ + T +GS ++ PE + K T+K D++S+ Sbjct: 150 NKGRNLKICDF-----GTVADKSTMMTNNRGSAAWMAPEVFEGSKYTEKCDIFSW 199
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 84.0 bits (206), Expect = 2e-16 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + Q L+ F+ E+ +L RH +++ +GY + ++ +V Sbjct: 97 VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVT 155 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ + K ++I A+G+ YLH AKSIIHRD+KS NI L Sbjct: 156 QWCEGSSLYHHLHIIETK-FEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLH 211 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 E+L K+ DFGL+ +H + GS ++ PE R Q + +SDVY+F Sbjct: 212 EDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAF 268
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 84.0 bits (206), Expect = 2e-16 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + Q L+ F+ E+ +L RH +++ +GY + ++ +V Sbjct: 511 VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVT 569 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ + K ++I A+G+ YLH AKSIIHRD+KS NI L Sbjct: 570 QWCEGSSLYHHLHIIETK-FEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLH 625 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 E+L K+ DFGL+ +H + GS ++ PE R Q + +SDVY+F Sbjct: 626 EDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAF 682
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 84.0 bits (206), Expect = 2e-16 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + Q L+ F+ E+ +L RH +++ +GY + ++ +V Sbjct: 33 VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVT 91 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ + K ++I A+G+ YLH AKSIIHRD+KS NI L Sbjct: 92 QWCEGSSLYHHLHIIETK-FEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLH 147 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 E+L K+ DFGL+ +H + GS ++ PE R Q + +SDVY+F Sbjct: 148 EDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAF 204
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 84.0 bits (206), Expect = 2e-16 Identities = 56/177 (31%), Positives = 97/177 (54%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEM--IL 179 V++A S +VA K Q S +F E +++ LRHR +V L+G C E +M ++ Sbjct: 234 VHRAKWGRSYEVAAKM-LQSSKAEREKFVLEAKIMHKLRHRKIVELLGVCTEPQDMPMLI 292 Query: 180 VYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 + EYM+ G+LK +L D + + V + + G+ YL + + ++HRD+++ NIL Sbjct: 293 IVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEISEGMAYLES---EKVVHRDLRADNIL 349 Query: 360 LDENLMAKVSDFGLSK-TGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + +L KV+DFGL++ T L T ++ + + PE + + T KSDV+S+ Sbjct: 350 VANDLTRKVADFGLTELTDGSLGDQEKKT-LRFPYKWTAPEAAKSKVFTSKSDVWSY 405
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 84.0 bits (206), Expect = 2e-16 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + Q L+ F+ E+ +L RH +++ +GY + ++ +V Sbjct: 511 VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVT 569 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ + K ++I A+G+ YLH AKSIIHRD+KS NI L Sbjct: 570 QWCEGSSLYHHLHIIETK-FEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLH 625 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 E+L K+ DFGL+ +H + GS ++ PE R Q + +SDVY+F Sbjct: 626 EDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAF 682
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 84.0 bits (206), Expect = 2e-16 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + Q L+ F+ E+ +L RH +++ +GY + ++ +V Sbjct: 471 VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVT 529 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ + K ++I A+G+ YLH AKSIIHRD+KS NI L Sbjct: 530 QWCEGSSLYHHLHIIETK-FEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLH 585 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 E+L K+ DFGL+ +H + GS ++ PE R Q + +SDVY+F Sbjct: 586 EDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAF 642
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 84.0 bits (206), Expect = 2e-16 Identities = 57/177 (32%), Positives = 91/177 (51%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + Q L+ F+ E+ +L RH +++ +GY + ++ +V Sbjct: 81 VYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVT 139 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ + K ++I A+G+ YLH AKSIIHRD+KS NI L Sbjct: 140 QWCEGSSLYHHLHIIETK-FEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLH 195 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 E+L K+ DFGL+ +H + GS ++ PE R Q + +SDVY+F Sbjct: 196 EDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAF 252
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 83.6 bits (205), Expect = 3e-16 Identities = 62/158 (39%), Positives = 83/158 (52%), Gaps = 14/158 (8%) Frame = +3 Query: 96 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICI 275 E +++ LRH +V L+G E+ LV EYMEKG L L PLS K R I + Sbjct: 63 EGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGR--IIV 120 Query: 276 GAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGL------SKTGPELD--QT 431 A G+ YLH K +IH+D+K NIL+D + K++D G+ SK E D Q Sbjct: 121 EAIEGMCYLHD---KGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQK 177 Query: 432 HVSTAVK----GSFGYLDPEYYR--RQKLTDKSDVYSF 527 VS+ K G+ Y+ PE+ K T+KSDVYSF Sbjct: 178 EVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSF 215
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 83.6 bits (205), Expect = 3e-16 Identities = 56/177 (31%), Positives = 90/177 (50%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + + + L+ FR E+ +L RH +++ +GY + N + +V Sbjct: 354 VYKGKWHGDVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVT 412 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ D + ++I A+G+ YLH AK+IIHRD+KS NI L Sbjct: 413 QWCEGSSLYYHLHVLDTK-FQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLH 468 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 E L K+ DFGL+ + + GS ++ PE R Q + +SDVYS+ Sbjct: 469 EGLTVKIGDFGLATVKTRWSGSQQVEQLTGSILWMAPEVIRMQDNNPFSFQSDVYSY 525
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 83.2 bits (204), Expect = 4e-16 Identities = 56/175 (32%), Positives = 89/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ V ++T+VAVK + F E ++ LRH+HLV L C ++ + +V Sbjct: 253 EVWAGVWNNTTQVAVKT-LKPGTMSPASFLDEAGVMKKLRHKHLVQLYAICSDREPIYIV 311 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM G+L +L + L +++ A G+ +L A+ IHRD+ + NIL+ Sbjct: 312 TEYMSGGSLLDYLSKGEGVNLQLPTLIDMAAQVASGMAFLE---AQGYIHRDLAARNILV 368 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 EN + KV+DFGL++ E D+ K + PE + T KSDV+SF Sbjct: 369 GENYICKVADFGLARL-IEDDEYTAHEGAKFPIKWTAPEAALYNRFTIKSDVWSF 422
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 83.2 bits (204), Expect = 4e-16 Identities = 54/182 (29%), Positives = 87/182 (47%), Gaps = 14/182 (7%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 +D VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 204 TLKSHL--YGSD------------MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDV 341 L L +G D L + + I A G+ YL ++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPXQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 342 KSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 + N + NL+ K+ DFG+S+ D V ++ PE +K T +SDV+ Sbjct: 681 ATRNCXVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW 740 Query: 522 SF 527 SF Sbjct: 741 SF 742
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 82.0 bits (201), Expect = 9e-16 Identities = 53/177 (29%), Positives = 85/177 (48%), Gaps = 14/177 (7%) Frame = +3 Query: 39 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 218 VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G L Sbjct: 569 VAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKF 628 Query: 219 L--YGSD------------MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANI 356 L +G D L + + I G+ YL ++ +HRD+ + N Sbjct: 629 LRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQICSGMVYL---ASQHFVHRDLATRNC 685 Query: 357 LLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 L+ NL+ K+ DFG+S+ D V ++ PE +K T +SDV+SF Sbjct: 686 LVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSF 742
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 81.6 bits (200), Expect = 1e-15 Identities = 55/164 (33%), Positives = 86/164 (52%) Frame = +3 Query: 36 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 215 KVA+K + + +F E E++ L H LV L G C EQ + LV+E+ME G L Sbjct: 387 KVAIKTIREGA-MSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSD 445 Query: 216 HLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDF 395 +L + + + + +C+ G+ YL +IHRD+ + N L+ EN + KVSDF Sbjct: 446 YL-RTQRGLFAAETLLGMCLDVCEGMAYLEEA---CVIHRDLAARNCLVGENQVIKVSDF 501 Query: 396 GLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 G+++ + DQ ST K + PE + + + KSDV+SF Sbjct: 502 GMTRFVLD-DQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSF 544
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 81.6 bits (200), Expect = 1e-15 Identities = 58/189 (30%), Positives = 100/189 (52%), Gaps = 14/189 (7%) Frame = +3 Query: 3 KVYKAVL---QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEM 173 KVY+A + + K A ++ Q + R E +L + L+H ++++L G C ++ + Sbjct: 157 KVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNL 216 Query: 174 ILVYEYMEKGTLKSHLYGSDMPP---LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 LV E+ G L L G +PP ++W ++ ARG++YLH IIHRD+K Sbjct: 217 CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQI------ARGMNYLHDEAIVPIIHRDLK 270 Query: 345 SANILLDE--------NLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKL 500 S+NIL+ + N + K++DFGL++ E +T +A G++ ++ PE R Sbjct: 271 SSNILILQKVENGDLSNKILKITDFGLAR---EWHRTTKMSAA-GTYAWMAPEVIRASMF 326 Query: 501 TDKSDVYSF 527 + SDV+S+ Sbjct: 327 SKGSDVWSY 335
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 81.3 bits (199), Expect = 2e-15 Identities = 59/157 (37%), Positives = 84/157 (53%), Gaps = 13/157 (8%) Frame = +3 Query: 96 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICI 275 E ++++ LRH +V L+G E+ + LV EYMEKG L L PLS K R I + Sbjct: 63 EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGR--IIL 120 Query: 276 GAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLS--KTGPELDQTHVS--- 440 G+ YLH K +IH+D+K NIL+D + K++D GL+ K +L+ + Sbjct: 121 EIIEGMCYLH---GKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELR 177 Query: 441 ----TAVK--GSFGYLDPEYYR--RQKLTDKSDVYSF 527 TA K G+ Y+ PE+ K T+KSDVYSF Sbjct: 178 EVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSF 214
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 81.3 bits (199), Expect = 2e-15 Identities = 59/176 (33%), Positives = 91/176 (51%), Gaps = 7/176 (3%) Frame = +3 Query: 21 LQDSTK--VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDE--QNEMILVYE 188 LQD+T VAVK+ + + LR+F EIE+L L+H ++V G C + + L+ E Sbjct: 871 LQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIME 930 Query: 189 YMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDE 368 Y+ G+L+ +L + KK ++ +G+ YL T K IHRD+ + NIL++ Sbjct: 931 YLPYGSLRDYLQ-KHKERIDHKKLLQYTSQICKGMEYLGT---KRYIHRDLATRNILVEN 986 Query: 369 NLMAKVSDFGLSKTGPELDQTHVSTAVKGS---FGYLDPEYYRRQKLTDKSDVYSF 527 K+ DFGL+K P+ D+ + G F Y PE K + SDV+SF Sbjct: 987 ENRVKIGDFGLTKVLPQ-DKEYYKVKEPGESPIFWYA-PESLTESKFSVASDVWSF 1040 Score = 44.7 bits (104), Expect = 2e-04 Identities = 42/127 (33%), Positives = 66/127 (51%), Gaps = 11/127 (8%) Frame = +3 Query: 63 KSHQGLRE-FRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL-YGSDM 236 K+H+ E F ++S L H+HLV G C E ILV E+++ G+L ++L + Sbjct: 585 KAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNS 644 Query: 237 PPLSWKKRVEICIGAARGLHY-LHTGFAKSIIHRDVKSANILL--DENL------MAKVS 389 + WK +G A+ L + +H KS+IH +V + NILL +E+ K+S Sbjct: 645 INILWK------LGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRKTGNPPFIKLS 698 Query: 390 DFGLSKT 410 D G+S T Sbjct: 699 DPGISIT 705
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 81.3 bits (199), Expect = 2e-15 Identities = 60/170 (35%), Positives = 91/170 (53%), Gaps = 7/170 (4%) Frame = +3 Query: 39 VAVKRGNQK--SHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 212 VAVK N K S L+ F+ E+ +L RH +++ +G C + + +V ++ E +L Sbjct: 452 VAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLY 510 Query: 213 SHLYGSDMPPLSWKKRVEICIG--AARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKV 386 H++ S+ +K I IG A+G+ YLH AK+IIHRD+KS NI L E+L K+ Sbjct: 511 KHVHVSET---KFKLNTLIDIGRQVAQGMDYLH---AKNIIHRDLKSNNIFLHEDLSVKI 564 Query: 387 SDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTD---KSDVYSF 527 DFGL+ + GS ++ PE R Q+L +SDVY+F Sbjct: 565 GDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAF 614
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 81.3 bits (199), Expect = 2e-15 Identities = 56/176 (31%), Positives = 93/176 (52%), Gaps = 1/176 (0%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V++ + +T VAVK + + EF E ++ LRH L+ L C ++ + +V Sbjct: 253 EVWEGLWNGTTSVAVKT-LKPGTMSVEEFLQEASIMKRLRHPKLIQLYAVCTKEEPIYIV 311 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E M+ G+L +L G D L ++ V++ A G+ YL ++ IHRD+ + NIL+ Sbjct: 312 TELMKYGSLLEYLRGED-GVLKIEQLVDVAAQVASGMSYLE---QQNYIHRDLAARNILV 367 Query: 363 DENLMAKVSDFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 E+ + KV+DFGL++ E+ + H T K + PE + T KSDV+SF Sbjct: 368 GEHGICKVADFGLARVIDEEIYEAH--TGAKFPIKWTAPEAAMYNRFTIKSDVWSF 421
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 81.3 bits (199), Expect = 2e-15 Identities = 48/151 (31%), Positives = 82/151 (54%), Gaps = 7/151 (4%) Frame = +3 Query: 96 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYG-SDMPPLSWKKRVEIC 272 E E+L R +++ ++G C+E + +V EYM G+L L+ ++ P ++W R I Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRIL 125 Query: 273 IGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK---TGPELDQTHVST 443 A G++YLH ++H D+K+ NILLD K++DFGLSK +++ S Sbjct: 126 HEIALGVNYLHN-MNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSYKSA 184 Query: 444 AVKGSFGYLDPEYY---RRQKLTDKSDVYSF 527 G+ Y+ PE Y ++ + + K D+YS+ Sbjct: 185 PEGGTIIYMPPENYEPGQKSRASVKHDIYSY 215
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 81.3 bits (199), Expect = 2e-15 Identities = 50/151 (33%), Positives = 83/151 (54%), Gaps = 7/151 (4%) Frame = +3 Query: 96 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYG-SDMPPLSWKKRVEIC 272 E E+L R +++ ++G C+E + +V EYM G+L L+ ++ P ++W R I Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRIL 125 Query: 273 IGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK-TGPELDQTHVSTAV 449 A G++YLH ++H D+K+ NILLD K++DFGLSK L Q+ S + Sbjct: 126 HEIALGVNYLHN-MTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSA 184 Query: 450 K--GSFGYLDPEYY---RRQKLTDKSDVYSF 527 G+ Y+ PE Y ++ + + K D+YS+ Sbjct: 185 PEGGTIIYMPPENYEPGQKSRASIKHDIYSY 215
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 80.9 bits (198), Expect = 2e-15 Identities = 55/177 (31%), Positives = 89/177 (50%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + + + L+ FR E+ +L RH +++ +GY + N + +V Sbjct: 363 VYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVT 421 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ + + ++I A+G+ YLH AK+IIHRD+KS NI L Sbjct: 422 QWCEGSSLYKHLHVQETK-FQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLH 477 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 E L K+ DFGL+ + GS ++ PE R Q + +SDVYS+ Sbjct: 478 EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSY 534
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 80.9 bits (198), Expect = 2e-15 Identities = 55/177 (31%), Positives = 89/177 (50%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + + + L+ FR E+ +L RH +++ +GY + N + +V Sbjct: 363 VYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVT 421 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ + + ++I A+G+ YLH AK+IIHRD+KS NI L Sbjct: 422 QWCEGSSLYKHLHVQETK-FQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLH 477 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 E L K+ DFGL+ + GS ++ PE R Q + +SDVYS+ Sbjct: 478 EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSY 534
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 80.9 bits (198), Expect = 2e-15 Identities = 54/175 (30%), Positives = 91/175 (52%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V++A+ + VAVK ++ + F+ EI+ + LRH+H++SL + + ++ Sbjct: 204 EVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYII 263 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E M KG L L SD L + V+ A G+ YL +++ IHRD+ + N+L+ Sbjct: 264 TELMPKGNLLQLLRDSDEKALPILELVDFASQVAEGMCYLE---SQNYIHRDLAARNVLV 320 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 EN + KV DFGL++ E ++S + + PE R + KSDV+SF Sbjct: 321 TENNLCKVGDFGLARLVKE--DIYLSHEHNVPYKWTAPEALSRGHYSIKSDVWSF 373
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 80.9 bits (198), Expect = 2e-15 Identities = 55/177 (31%), Positives = 89/177 (50%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + + + L+ FR E+ +L RH +++ +GY + N + +V Sbjct: 38 VYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVT 96 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ + + ++I A+G+ YLH AK+IIHRD+KS NI L Sbjct: 97 QWCEGSSLYKHLHVQETK-FQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLH 152 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 E L K+ DFGL+ + GS ++ PE R Q + +SDVYS+ Sbjct: 153 EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSY 209
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 80.9 bits (198), Expect = 2e-15 Identities = 54/175 (30%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +STKVAVK + ++ F E L+ L+H LV L + + ++ Sbjct: 259 EVWMGYYNNSTKVAVKT-LKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYII 317 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L + + K ++ A G+ Y+ K+ IHRD+++AN+L+ Sbjct: 318 TEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER---KNYIHRDLRAANVLV 374 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 E+LM K++DFGL++ + + T K + PE T KSDV+SF Sbjct: 375 SESLMCKIADFGLARVIEDNEYT-AREGAKFPIKWTAPEAINFGCFTIKSDVWSF 428
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 80.5 bits (197), Expect = 3e-15 Identities = 58/175 (33%), Positives = 89/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ TKVA+K Q S F E L+ L+H LV L ++ + ++ Sbjct: 256 EVWMGFYNGHTKVAIKNLKQGS-MSPSAFLAEANLMKNLQHPRLVRLYAVVTKE-PIYII 313 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYMEKG+L L S+ LS K +++ A G+ ++ AK+ IHRD+++ANIL+ Sbjct: 314 TEYMEKGSLVDFLKTSEGIKLSINKLLDMAAQIAEGMAFIE---AKNYIHRDLRAANILV 370 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 E L K++DFGL++ + + T K + PE T KSDV+SF Sbjct: 371 SEALCCKIADFGLARLIEDNEYT-AREGAKFPIKWTAPEAINYGTFTIKSDVWSF 424
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 80.5 bits (197), Expect = 3e-15 Identities = 52/147 (35%), Positives = 83/147 (56%), Gaps = 3/147 (2%) Frame = +3 Query: 96 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICI 275 E++L++ L H +++ +G C Q ++ + EY+ G L+ L S++ L W RV++ Sbjct: 101 EVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLE-QLLDSNL-HLPWTVRVKLAY 158 Query: 276 GAARGLHYLHTGFAKSIIHRDVKSANILL--DEN-LMAKVSDFGLSKTGPELDQTHVSTA 446 A GL YLH K I HRD+ S N L+ DEN A V+DFGL++ P++ A Sbjct: 159 DIAVGLSYLH---FKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLA 215 Query: 447 VKGSFGYLDPEYYRRQKLTDKSDVYSF 527 V GS ++ PE R + +K+DV+S+ Sbjct: 216 VVGSPFWMAPEVLRDEPYNEKADVFSY 242
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 80.5 bits (197), Expect = 3e-15 Identities = 52/175 (29%), Positives = 95/175 (54%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V++ + +D +VA+K ++ + + ++EI+ + LRH+H+++L + + ++ Sbjct: 204 EVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYII 263 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E M KG+L L SD L + ++I A G+ YL +++ IHRD+ + NIL+ Sbjct: 264 TELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE---SQNYIHRDLAARNILV 320 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 EN + KV DFGL++ E ++S + + PE R + KSDV+SF Sbjct: 321 GENTLCKVGDFGLARLIKE--DVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSF 373
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 80.5 bits (197), Expect = 3e-15 Identities = 54/178 (30%), Positives = 94/178 (52%), Gaps = 5/178 (2%) Frame = +3 Query: 6 VYKAVLQDSTKVAV-----KRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNE 170 VYKA +D +KV KRG ++ + L+ R E ++ + L+H H++ +I + + + Sbjct: 18 VYKATRKDDSKVVAIKVISKRG--RATKELKNLRRECDIQARLKHPHVIEMIESFESKTD 75 Query: 171 MILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 + +V E+ + H Y S + + + L+YLH+ I+HRD+K Sbjct: 76 LFVVTEF---ALMDLHRYLSYNGAMGEEPARRVTGHLVSALYYLHSN---RILHRDLKPQ 129 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 N+LLD+N+ AK+ DFGL++ THV T++KG+ Y+ PE Q +D++S Sbjct: 130 NVLLDKNMHAKLCDFGLARN--MTLGTHVLTSIKGTPLYMAPELLAEQPYDHHADMWS 185
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 80.5 bits (197), Expect = 3e-15 Identities = 59/190 (31%), Positives = 92/190 (48%), Gaps = 15/190 (7%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGL----REFRTEIELLSGLRHRHLVSLIGYCDEQNE 170 KVY+ + VAVK Q + + R E L + L H ++++L C E+ Sbjct: 130 KVYRGSWRGEL-VAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPN 188 Query: 171 MILVYEYMEKGTLKSHLYGSDMPP---LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDV 341 + LV EY G L L G +PP ++W ++ ARG+HYLH +IHRD+ Sbjct: 189 LCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQI------ARGMHYLHCEALVPVIHRDL 242 Query: 342 KSANILL--------DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQK 497 KS NILL E+ K++DFGL++ + Q + G++ ++ PE + Sbjct: 243 KSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQ----MSAAGTYAWMAPEVIKAST 298 Query: 498 LTDKSDVYSF 527 + SDV+SF Sbjct: 299 FSKGSDVWSF 308
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 80.5 bits (197), Expect = 3e-15 Identities = 57/183 (31%), Positives = 95/183 (51%), Gaps = 8/183 (4%) Frame = +3 Query: 3 KVYKAVLQDSTK----VAVKRGNQK-SHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQN 167 KVYK L K VA+K + S + ++F+ EIEL+S L+H+++V ++G + Sbjct: 423 KVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKE 482 Query: 168 EMILVYEYMEKGTLKSHLYG---SDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRD 338 +++EYM G L L ++ LS + ++I + + G+ YL A +HRD Sbjct: 483 PYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQIALQISEGMQYLS---AHHYVHRD 539 Query: 339 VKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDV 518 + + N L++E L+ K+SDFGLS+ D V + ++ E K T +SDV Sbjct: 540 LAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDV 599 Query: 519 YSF 527 +SF Sbjct: 600 WSF 602
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 80.1 bits (196), Expect = 3e-15 Identities = 57/177 (32%), Positives = 94/177 (53%), Gaps = 2/177 (1%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 +VYK L+D T VAVK + Q L+ +F E ++L H ++V LIG C ++ + + Sbjct: 576 EVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYI 635 Query: 180 VYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 + E + G + L L K+ V+ + AA G+ YL + K+ IHRD+ + N L Sbjct: 636 IMELVSGGDFLTFLRRKK-DELKLKQLVKFSLDAAAGMLYLES---KNCIHRDLAARNCL 691 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVSTAVKG-SFGYLDPEYYRRQKLTDKSDVYSF 527 + EN + K+SDFG+S+ E + S+ +K + PE + + +SDV+SF Sbjct: 692 VGENNVLKISDFGMSR--QEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSF 746
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 80.1 bits (196), Expect = 3e-15 Identities = 55/175 (31%), Positives = 89/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V++ + +T VAVK + + EF E ++ LRH L+ L C ++ + +V Sbjct: 253 EVWEGLWNGTTSVAVKT-LKPGTMSIEEFLEEASIMKQLRHPKLIQLYAVCTKEEPIYIV 311 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E M+ G+L +L G D L V++C A G+ YL ++ IHRD+ + NIL+ Sbjct: 312 TELMKHGSLLEYLRG-DGRSLKLPDLVDMCSQVASGMSYLEQ---QNYIHRDLAARNILV 367 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 E+ + KV+DFGL++ E + K + PE + T KSDV+SF Sbjct: 368 GEHKICKVADFGLARVIDE-EIYEAKLGAKFPIKWTAPEAAMYSRFTIKSDVWSF 421
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 80.1 bits (196), Expect = 3e-15 Identities = 56/165 (33%), Positives = 95/165 (57%), Gaps = 2/165 (1%) Frame = +3 Query: 39 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 218 VA+K+ +S + + F E+ LS + H ++V L G C N + LV EY E G+L + Sbjct: 60 VAIKQIESESER--KAFIVELRQLSRVNHPNIVKLYGAC--LNPVCLVMEYAEGGSLYNV 115 Query: 219 LYGSD-MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL-DENLMAKVSD 392 L+G++ +P + + C+ ++G+ YLH+ K++IHRD+K N+LL + K+ D Sbjct: 116 LHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICD 175 Query: 393 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 FG T ++ QTH+ T KGS ++ PE + ++K DV+S+ Sbjct: 176 FG---TACDI-QTHM-TNNKGSAAWMAPEVFEGSNYSEKCDVFSW 215
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 80.1 bits (196), Expect = 3e-15 Identities = 58/176 (32%), Positives = 91/176 (51%), Gaps = 7/176 (3%) Frame = +3 Query: 21 LQDSTK--VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDE--QNEMILVYE 188 LQD+T VAVK+ + + LR+F EIE+L L+H ++V G C + + L+ E Sbjct: 871 LQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIME 930 Query: 189 YMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDE 368 Y+ G+L+ +L + KK ++ +G+ YL T K IHRD+ + NIL++ Sbjct: 931 YLPYGSLRDYLQ-KHKERIDHKKLLQYTSQICKGMEYLGT---KRYIHRDLATRNILVEN 986 Query: 369 NLMAKVSDFGLSKTGPELDQTHVSTAVKGS---FGYLDPEYYRRQKLTDKSDVYSF 527 K+ DFGL+K P+ D+ + G F Y P+ K + SDV+SF Sbjct: 987 ENRVKIGDFGLTKVLPQ-DKEYYKVKEPGESPIFWYA-PQSLTESKFSVASDVWSF 1040 Score = 44.7 bits (104), Expect = 2e-04 Identities = 42/127 (33%), Positives = 66/127 (51%), Gaps = 11/127 (8%) Frame = +3 Query: 63 KSHQGLRE-FRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL-YGSDM 236 K+H+ E F ++S L H+HLV G C E ILV E+++ G+L ++L + Sbjct: 585 KAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNS 644 Query: 237 PPLSWKKRVEICIGAARGLHY-LHTGFAKSIIHRDVKSANILL--DENL------MAKVS 389 + WK +G A+ L + +H KS+IH +V + NILL +E+ K+S Sbjct: 645 INILWK------LGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLS 698 Query: 390 DFGLSKT 410 D G+S T Sbjct: 699 DPGISIT 705
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 80.1 bits (196), Expect = 3e-15 Identities = 56/165 (33%), Positives = 95/165 (57%), Gaps = 2/165 (1%) Frame = +3 Query: 39 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 218 VA+K+ +S + + F E+ LS + H ++V L G C N + LV EY E G+L + Sbjct: 60 VAIKQIESESER--KAFIVELRQLSRVNHPNIVKLYGAC--LNPVCLVMEYAEGGSLYNV 115 Query: 219 LYGSD-MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL-DENLMAKVSD 392 L+G++ +P + + C+ ++G+ YLH+ K++IHRD+K N+LL + K+ D Sbjct: 116 LHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICD 175 Query: 393 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 FG T ++ QTH+ T KGS ++ PE + ++K DV+S+ Sbjct: 176 FG---TACDI-QTHM-TNNKGSAAWMAPEVFEGSNYSEKCDVFSW 215
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 79.7 bits (195), Expect = 4e-15 Identities = 55/165 (33%), Positives = 86/165 (52%), Gaps = 1/165 (0%) Frame = +3 Query: 36 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYC-DEQNEMILVYEYMEKGTLK 212 KVAVK K+ + F E +++ LRH +LV L+G +E++ + +V EYM KG+L Sbjct: 218 KVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLV 275 Query: 213 SHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSD 392 +L L ++ + + YL A + +HRD+ + N+L+ E+ +AKVSD Sbjct: 276 DYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE---ANNFVHRDLAARNVLVSEDNIAKVSD 332 Query: 393 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 FGL+K T K + PE R +K + KSDV+SF Sbjct: 333 FGLTKEASSTQDTG-----KLPVKWTAPEALREKKFSTKSDVWSF 372
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC 2.7.10.1)| (FGFR-1) Length = 812 Score = 79.7 bits (195), Expect = 4e-15 Identities = 53/181 (29%), Positives = 95/181 (52%), Gaps = 16/181 (8%) Frame = +3 Query: 33 TKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGT 206 TKVAVK + S + L + +E+E++ + +H+++++L+G C + + ++ EY KG Sbjct: 503 TKVAVKMLKSDASEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYTSKGN 562 Query: 207 LKSHLYGSDMPP--------------LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 L+ +L P LS+K V ARG+ YL + K IHRD+ Sbjct: 563 LREYLRARRPPAMEYCYNPTCVPDQLLSFKDLVSCAYQVARGMDYLAS---KKCIHRDLA 619 Query: 345 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + N+L+ E+ + K++DFGL++ +D +T + ++ PE + T +SDV+S Sbjct: 620 ARNVLVTEDNIMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 679 Query: 525 F 527 F Sbjct: 680 F 680
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 79.7 bits (195), Expect = 4e-15 Identities = 59/177 (33%), Positives = 95/177 (53%), Gaps = 4/177 (2%) Frame = +3 Query: 9 YKAVLQDS---TKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 + AVLQ KVAVK N K + F E +++ ++H +LV L+G Q + + Sbjct: 246 FGAVLQGEYLGQKVAVK--NIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG-LYI 302 Query: 180 VYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 V E++ KG L + L ++ + ++ + A G+ YL + K ++HRD+ + NIL Sbjct: 303 VMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLES---KKLVHRDLAARNIL 359 Query: 360 LDENLMAKVSDFGLSKTGPE-LDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + E+L+AKVSDFGL+K + LD + + + PE + K T KSDV+SF Sbjct: 360 VSEDLVAKVSDFGLAKAERKGLDSSRLPVK------WTAPEALKHGKFTSKSDVWSF 410
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 79.7 bits (195), Expect = 4e-15 Identities = 53/147 (36%), Positives = 82/147 (55%), Gaps = 3/147 (2%) Frame = +3 Query: 96 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICI 275 E++L++ L H +++ +G C Q ++ + EY+ G L+ L SD+ L W RV++ Sbjct: 101 EMQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLE-QLLDSDL-YLPWTVRVKLAY 158 Query: 276 GAARGLHYLHTGFAKSIIHRDVKSANILL--DEN-LMAKVSDFGLSKTGPELDQTHVSTA 446 A GL YLH K I HRD+ S N L+ DEN A V+DFGL++ P+ A Sbjct: 159 DIAVGLSYLH---FKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDASIGREKLA 215 Query: 447 VKGSFGYLDPEYYRRQKLTDKSDVYSF 527 V GS ++ PE R + +K+DV+S+ Sbjct: 216 VVGSPFWMAPEVLRDEPYNEKADVFSY 242
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 79.7 bits (195), Expect = 4e-15 Identities = 54/177 (30%), Positives = 88/177 (49%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + + + + FR E+ +L RH +++ +GY + N + +V Sbjct: 363 VYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVT 421 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ + + ++I A+G+ YLH AK+IIHRD+KS NI L Sbjct: 422 QWCEGSSLYKHLHVQETK-FQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLH 477 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 E L K+ DFGL+ + GS ++ PE R Q + +SDVYS+ Sbjct: 478 EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSY 534
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 79.7 bits (195), Expect = 4e-15 Identities = 53/175 (30%), Positives = 89/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +STKVAVK + ++ F E L+ L+H LV L ++ + ++ Sbjct: 259 EVWMGYYNNSTKVAVKT-LKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYII 317 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E+M KG+L L + + K ++ A G+ Y+ K+ IHRD+++AN+L+ Sbjct: 318 TEFMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER---KNYIHRDLRAANVLV 374 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 E+LM K++DFGL++ + + T K + PE T KSDV+SF Sbjct: 375 SESLMCKIADFGLARVIEDNEYT-AREGAKFPIKWTAPEAINFGCFTIKSDVWSF 428
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 79.7 bits (195), Expect = 4e-15 Identities = 59/177 (33%), Positives = 95/177 (53%), Gaps = 4/177 (2%) Frame = +3 Query: 9 YKAVLQDS---TKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 + AVLQ KVAVK N K + F E +++ L+HR+LV L+G + + Sbjct: 244 FGAVLQGEYLGQKVAVK--NIKCDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHG-LYI 300 Query: 180 VYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 V E++ KG L + L +S + ++ + A G+ YL + K ++HRD+ + NIL Sbjct: 301 VMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLES---KKLVHRDLAARNIL 357 Query: 360 LDENLMAKVSDFGLSKTGPE-LDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + E+L+AKVSDFGL+K + LD + + + PE + + + KSDV+SF Sbjct: 358 VSEDLVAKVSDFGLAKAERKGLDSSRLPVK------WTAPEALKNGRFSSKSDVWSF 408
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 79.3 bits (194), Expect = 6e-15 Identities = 54/177 (30%), Positives = 88/177 (49%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + + + + FR E+ +L RH +++ +GY + N + +V Sbjct: 363 VYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVT 421 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ + + ++I A+G+ YLH AK+IIHRD+KS NI L Sbjct: 422 QWCEGSSLYKHLHVQETK-FQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLH 477 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 E L K+ DFGL+ + GS ++ PE R Q + +SDVYS+ Sbjct: 478 EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSY 534
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 79.3 bits (194), Expect = 6e-15 Identities = 52/181 (28%), Positives = 95/181 (52%), Gaps = 16/181 (8%) Frame = +3 Query: 33 TKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGT 206 TKVAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY KG Sbjct: 507 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 566 Query: 207 LKSHLYGSDMP--------------PLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 L+ +L P LS+K V ARG+ YL + K IHRD+ Sbjct: 567 LREYLQARRPPGMEYCYNPTRIPEEQLSFKDLVSCAYQVARGMEYLAS---KKCIHRDLA 623 Query: 345 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + N+L+ E+ + K++DFGL++ +D +T + ++ PE + T +SDV+S Sbjct: 624 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 683 Query: 525 F 527 F Sbjct: 684 F 684
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 79.3 bits (194), Expect = 6e-15 Identities = 53/175 (30%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +STKVAVK + + F E L+ L+H LV L ++ + ++ Sbjct: 259 EVWMGYYNNSTKVAVKT-LKPGTMSAQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYII 317 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E+M KG+L L + + K ++ A G+ Y+ K+ IHRD+++AN+L+ Sbjct: 318 TEFMAKGSLLDFLKSDEGSKVLLPKLIDFSAQIAEGMAYIER---KNYIHRDLRAANVLV 374 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 E+LM K++DFGL++ + + T K + PE T KSDV+SF Sbjct: 375 SESLMCKIADFGLARVIEDNEYT-AREGAKFPIKWTAPEAINFGCFTIKSDVWSF 428
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 79.3 bits (194), Expect = 6e-15 Identities = 59/176 (33%), Positives = 92/176 (52%), Gaps = 3/176 (1%) Frame = +3 Query: 9 YKAVLQDS---TKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 + AVLQ KVAVK N K + F E +++ L+HR+LV L+G + + Sbjct: 205 FGAVLQGEYLGQKVAVK--NIKCDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHG-LYI 261 Query: 180 VYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 V E++ KG L + L +S + ++ + A G+ YL + K ++HRD+ + NIL Sbjct: 262 VMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLES---KKLVHRDLAARNIL 318 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + E+L+AKVSDFGL+K VK + PE + + + KSDV+SF Sbjct: 319 VSEDLVAKVSDFGLAKAELRKGLDSSRLPVK----WTAPEALKNGRFSSKSDVWSF 370
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 79.0 bits (193), Expect = 8e-15 Identities = 53/175 (30%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ ++S VAVK + + F E ++ RH LV+L C ++ + +V Sbjct: 297 EVFYGKWRNSIDVAVKTLREGT-MSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIV 355 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L D L ++ + I A G+ YL +K +IHRD+ + N+L+ Sbjct: 356 QEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLE---SKQLIHRDLAARNVLI 412 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 EN +AK+ DFGL++ + D+ + + PE K + KSDV+S+ Sbjct: 413 GENNVAKICDFGLARVIAD-DEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSY 466
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 78.6 bits (192), Expect = 1e-14 Identities = 56/175 (32%), Positives = 89/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ D+T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 279 EVWMGTWNDTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIV 336 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 337 IEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 393 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 394 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 447
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 78.6 bits (192), Expect = 1e-14 Identities = 60/192 (31%), Positives = 95/192 (49%), Gaps = 17/192 (8%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQG----LREFRTEIELLSGLRHRHLVSLIGYCDEQNE 170 KVY+A+ + +VAVK + + E L L+H ++++L G C Sbjct: 111 KVYRALWRGE-EVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPH 169 Query: 171 MILVYEYMEKGTLKSHLYGSDMPP---LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDV 341 + LV EY G L L G +PP ++W +V ARG++YLH IIHRD+ Sbjct: 170 LCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQV------ARGMNYLHNDAPVPIIHRDL 223 Query: 342 KSANILLDE--------NLMAKVSDFGLSKTGPELDQTHVST--AVKGSFGYLDPEYYRR 491 KS NIL+ E + + K++DFGL++ + H +T + G++ ++ PE R Sbjct: 224 KSINILILEAIENHNLADTVLKITDFGLAR------EWHKTTKMSAAGTYAWMAPEVIRL 277 Query: 492 QKLTDKSDVYSF 527 + SDV+SF Sbjct: 278 SLFSKSSDVWSF 289
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 78.2 bits (191), Expect = 1e-14 Identities = 58/180 (32%), Positives = 100/180 (55%), Gaps = 5/180 (2%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLRE---FRTEIELLSGLRHRHLVSLIGYC-DEQNE 170 KVYK ++ VA+KR ++ + F E+ +L L H +V +G C D+ ++ Sbjct: 475 KVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQ 533 Query: 171 MILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 +V +Y+ G+L S L+ L + ++ I + A+G+ YLH+ + IIHRD+ S Sbjct: 534 FAIVTQYISGGSLFSLLH-EQKRILDLQSKLIIAVDVAKGMEYLHS-LTQPIIHRDLNSH 591 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRR-QKLTDKSDVYSF 527 NILL E+ A V+DFG S+ LD+ ++ T G+ ++ PE + + + T K+DV+S+ Sbjct: 592 NILLYEDGHAVVADFGESRFLQSLDEDNM-TKQPGNLRWMAPEVFTQCTRYTIKADVFSY 650
>STE11_YEAST (P23561) Serine/threonine-protein kinase STE11 (EC 2.7.11.1)| Length = 738 Score = 78.2 bits (191), Expect = 1e-14 Identities = 55/172 (31%), Positives = 91/172 (52%), Gaps = 4/172 (2%) Frame = +3 Query: 21 LQDSTKVAVKRGNQKSHQGLRE-FRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYME 197 ++D V+ + NQ H+ + + + E+ LL L H ++V+ G E + + EY+ Sbjct: 499 IEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVP 558 Query: 198 KGTLKSHL--YGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDEN 371 G++ S L YG L +I IG A YLH K+IIHRD+K ANIL+D Sbjct: 559 GGSVSSMLNNYGPFEESLITNFTRQILIGVA----YLHK---KNIIHRDIKGANILIDIK 611 Query: 372 LMAKVSDFGLS-KTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 K++DFG+S K P + + +++GS ++ PE ++ T K+D++S Sbjct: 612 GCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWS 663
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 78.2 bits (191), Expect = 1e-14 Identities = 53/151 (35%), Positives = 82/151 (54%), Gaps = 7/151 (4%) Frame = +3 Query: 96 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK----SHLYGSDMPPLSWKKRV 263 E++L++ L H +++ +G C Q ++ + EY+ G L+ S+LY L W RV Sbjct: 101 EMQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLDSNLY------LPWTVRV 154 Query: 264 EICIGAARGLHYLHTGFAKSIIHRDVKSANILL--DEN-LMAKVSDFGLSKTGPELDQTH 434 ++ A GL YLH K I HRD+ S N L+ DEN A V+DFGL++ P+ Sbjct: 155 KLAYDIAVGLSYLH---FKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDASIGS 211 Query: 435 VSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 AV GS ++ PE R + +K+DV+S+ Sbjct: 212 EKLAVVGSPFWMAPEVLRDEPYNEKADVFSY 242
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 78.2 bits (191), Expect = 1e-14 Identities = 58/176 (32%), Positives = 90/176 (51%), Gaps = 7/176 (3%) Frame = +3 Query: 21 LQDSTK--VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDE--QNEMILVYE 188 LQD+T VAVK+ + + LR+F EIE+L L+H ++V G C + + L+ E Sbjct: 871 LQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIME 930 Query: 189 YMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDE 368 Y+ G+L+ +L + K ++ +G+ YL T K IHRD+ + NIL++ Sbjct: 931 YLPYGSLRDYLQ-KHKERIDHIKLLQYTSQICKGMEYLGT---KRYIHRDLATRNILVEN 986 Query: 369 NLMAKVSDFGLSKTGPELDQTHVSTAVKGS---FGYLDPEYYRRQKLTDKSDVYSF 527 K+ DFGL+K P+ D+ + G F Y PE K + SDV+SF Sbjct: 987 ENRVKIGDFGLTKVLPQ-DKEYYKVKEPGESPIFWYA-PESLTESKFSVASDVWSF 1040 Score = 44.3 bits (103), Expect = 2e-04 Identities = 40/126 (31%), Positives = 66/126 (52%), Gaps = 10/126 (7%) Frame = +3 Query: 63 KSHQGLRE-FRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL-YGSDM 236 K+H+ E F ++S L H+HLV G C +E ILV E+++ G+L ++L + Sbjct: 585 KAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNC 644 Query: 237 PPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL--DENL------MAKVSD 392 + WK +E+ A +H+L ++IH +V + NILL +E+ K+SD Sbjct: 645 INILWK--LEVAKQLAWAMHFLE---ENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSD 699 Query: 393 FGLSKT 410 G+S T Sbjct: 700 PGISIT 705
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 78.2 bits (191), Expect = 1e-14 Identities = 58/180 (32%), Positives = 100/180 (55%), Gaps = 5/180 (2%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLRE---FRTEIELLSGLRHRHLVSLIGYC-DEQNE 170 KVYK ++ VA+KR ++ + F E+ +L L H +V +G C D+ ++ Sbjct: 474 KVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQ 532 Query: 171 MILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 +V +Y+ G+L S L+ L + ++ I + A+G+ YLH+ + IIHRD+ S Sbjct: 533 FAIVTQYISGGSLFSLLH-EQKRILDLQSKLIIAVDVAKGMEYLHS-LTQPIIHRDLNSH 590 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRR-QKLTDKSDVYSF 527 NILL E+ A V+DFG S+ LD+ ++ T G+ ++ PE + + + T K+DV+S+ Sbjct: 591 NILLYEDGHAVVADFGESRFLQSLDEDNM-TKQPGNLRWMAPEVFTQCTRYTIKADVFSY 649
>FGFR1_RAT (Q04589) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 77.8 bits (190), Expect = 2e-14 Identities = 51/181 (28%), Positives = 94/181 (51%), Gaps = 16/181 (8%) Frame = +3 Query: 33 TKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGT 206 TKVAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY KG Sbjct: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 568 Query: 207 LKSHLYGSDMPPLSW--------------KKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 L+ +L P L + K V ARG+ YL + K IHRD+ Sbjct: 569 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS---KKCIHRDLA 625 Query: 345 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + N+L+ E+ + K++DFGL++ +D +T + ++ PE + T +SDV+S Sbjct: 626 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 685 Query: 525 F 527 F Sbjct: 686 F 686
>FGFR1_MOUSE (P16092) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 77.8 bits (190), Expect = 2e-14 Identities = 51/181 (28%), Positives = 94/181 (51%), Gaps = 16/181 (8%) Frame = +3 Query: 33 TKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGT 206 TKVAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY KG Sbjct: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 568 Query: 207 LKSHLYGSDMPPLSW--------------KKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 L+ +L P L + K V ARG+ YL + K IHRD+ Sbjct: 569 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS---KKCIHRDLA 625 Query: 345 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + N+L+ E+ + K++DFGL++ +D +T + ++ PE + T +SDV+S Sbjct: 626 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 685 Query: 525 F 527 F Sbjct: 686 F 686
>FGFR1_HUMAN (P11362) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 77.8 bits (190), Expect = 2e-14 Identities = 51/181 (28%), Positives = 94/181 (51%), Gaps = 16/181 (8%) Frame = +3 Query: 33 TKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGT 206 TKVAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY KG Sbjct: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 568 Query: 207 LKSHLYGSDMPPLSW--------------KKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 L+ +L P L + K V ARG+ YL + K IHRD+ Sbjct: 569 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS---KKCIHRDLA 625 Query: 345 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + N+L+ E+ + K++DFGL++ +D +T + ++ PE + T +SDV+S Sbjct: 626 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 685 Query: 525 F 527 F Sbjct: 686 F 686
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 77.8 bits (190), Expect = 2e-14 Identities = 55/196 (28%), Positives = 89/196 (45%), Gaps = 28/196 (14%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 +D VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 204 TLKSHL--YGSD------------MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDV 341 L L +G D L + + I A G+ YL ++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 342 KSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSF--------------GYLDPE 479 + N L+ NL+ K+ DFG+S+ D + F ++ PE Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPE 740 Query: 480 YYRRQKLTDKSDVYSF 527 +K T +SDV+SF Sbjct: 741 SIMYRKFTTESDVWSF 756
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 77.8 bits (190), Expect = 2e-14 Identities = 54/165 (32%), Positives = 84/165 (50%), Gaps = 1/165 (0%) Frame = +3 Query: 36 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYC-DEQNEMILVYEYMEKGTLK 212 KVAVK K+ + F E +++ LRH +LV L+G +E+ + +V EYM KG+L Sbjct: 218 KVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLV 275 Query: 213 SHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSD 392 +L L ++ + + YL + +HRD+ + N+L+ E+ +AKVSD Sbjct: 276 DYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE---GNNFVHRDLAARNVLVSEDNVAKVSD 332 Query: 393 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 FGL+K T K + PE R +K + KSDV+SF Sbjct: 333 FGLTKEASSTQDTG-----KLPVKWTAPEALREKKFSTKSDVWSF 372
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 77.8 bits (190), Expect = 2e-14 Identities = 54/165 (32%), Positives = 84/165 (50%), Gaps = 1/165 (0%) Frame = +3 Query: 36 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYC-DEQNEMILVYEYMEKGTLK 212 KVAVK K+ + F E +++ LRH +LV L+G +E+ + +V EYM KG+L Sbjct: 218 KVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLV 275 Query: 213 SHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSD 392 +L L ++ + + YL + +HRD+ + N+L+ E+ +AKVSD Sbjct: 276 DYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE---GNNFVHRDLAARNVLVSEDNVAKVSD 332 Query: 393 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 FGL+K T K + PE R +K + KSDV+SF Sbjct: 333 FGLTKEASSTQDTG-----KLPVKWTAPEALREKKFSTKSDVWSF 372
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 77.4 bits (189), Expect = 2e-14 Identities = 54/165 (32%), Positives = 84/165 (50%), Gaps = 1/165 (0%) Frame = +3 Query: 36 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYC-DEQNEMILVYEYMEKGTLK 212 KVAVK K+ + F E +++ LRH +LV L+G +E+ + +V EYM KG+L Sbjct: 218 KVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLV 275 Query: 213 SHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSD 392 +L L ++ + + YL + +HRD+ + N+L+ E+ +AKVSD Sbjct: 276 DYLRSRGRSVLGGDCLLKFSLDVLEAMEYLE---GNNFVHRDLAARNVLVSEDNVAKVSD 332 Query: 393 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 FGL+K T K + PE R +K + KSDV+SF Sbjct: 333 FGLTKEASSTQDTG-----KLPVKWTAPEALREKKFSTKSDVWSF 372
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 77.4 bits (189), Expect = 2e-14 Identities = 51/149 (34%), Positives = 77/149 (51%) Frame = +3 Query: 78 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKK 257 +R FR E + S L H ++VS+ +E + +V EY+E TLK ++ + PL K+ Sbjct: 53 IRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITANG--PLHPKE 110 Query: 258 RVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV 437 + I + + H I+HRD+K NIL+D KV+DFG++ TH Sbjct: 111 ALNIMEQIVSAIAHAHQN---QIVHRDIKPHNILIDHMGNIKVTDFGIATALSSTTITH- 166 Query: 438 STAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + +V GS YL PE R T KSD+Y+ Sbjct: 167 TNSVLGSVHYLSPEQARGGLATKKSDIYA 195
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 77.4 bits (189), Expect = 2e-14 Identities = 48/152 (31%), Positives = 79/152 (51%), Gaps = 4/152 (2%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYG-SDMPPLSWKK 257 R F+ E+++ H +++ ++G+C + +Y YM G+L+ L G PL W + Sbjct: 252 RFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQ 311 Query: 258 RVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSD--FGLSKTGPELDQT 431 RV IC G + YLH IIH +VKS+N+LLD+NL K++ L T Sbjct: 312 RVSICSGLLCAVEYLH---GLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYT 368 Query: 432 HVST-AVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + T ++ S YL ++ R +LT + D++S Sbjct: 369 MMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFS 400
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 77.4 bits (189), Expect = 2e-14 Identities = 57/177 (32%), Positives = 90/177 (50%), Gaps = 2/177 (1%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 +VYK L+D T VAVK + Q L+ +F E ++L H ++V LIG C ++ + + Sbjct: 77 EVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYI 136 Query: 180 VYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 + E + G S L L K+ V + A G+ YL K+ IHRD+ + N L Sbjct: 137 IMELVPGGDFLSFLR-KRKDELKLKQLVRFSLDVAAGMLYLE---GKNCIHRDLAARNCL 192 Query: 360 LDENLMAKVSDFGLSKTGPELDQTHVSTAVKG-SFGYLDPEYYRRQKLTDKSDVYSF 527 + EN K+SDFG+S+ E + S+ +K + PE + + +SDV+SF Sbjct: 193 VGENNTLKISDFGMSR--QEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSF 247
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 77.4 bits (189), Expect = 2e-14 Identities = 56/175 (32%), Positives = 87/175 (49%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +TKVAVK + F E +++ LRH LV L E+ + +V Sbjct: 283 EVWMGTWNGTTKVAVKT-LKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSEE-PIYIV 340 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L + L V++ A G+ Y+ + IHRD++SANIL+ Sbjct: 341 TEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSANILV 397 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +NL+ K++DFGL++ + + T K + PE + T KSDV+SF Sbjct: 398 GDNLVCKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 451
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 77.4 bits (189), Expect = 2e-14 Identities = 49/156 (31%), Positives = 78/156 (50%), Gaps = 8/156 (5%) Frame = +3 Query: 84 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDM--PPLSWKK 257 EF TE ++ H +++ LIG +++V EYM G+L L +D + W+K Sbjct: 761 EFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEK 820 Query: 258 RVEICIGAARGLHYL-HTGFAKSI-IHRDVKSANILLDENLMAKVSDFGLSK----TGPE 419 E+ G A G+ YL G+ + RD+ + N+LLD L K++DFGLS+ G Sbjct: 821 ITEMLYGIASGMKYLTDMGYVHRVSFLRDLAARNVLLDMELRCKIADFGLSRGVRSEGSS 880 Query: 420 LDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ++ + + K + PE +K T SDV+SF Sbjct: 881 VEPEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSF 916
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 77.4 bits (189), Expect = 2e-14 Identities = 59/153 (38%), Positives = 83/153 (54%), Gaps = 5/153 (3%) Frame = +3 Query: 84 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRV 263 E E + + + R+++ + G C E + LV EYME G+L+ L PL W R Sbjct: 65 ELLEEAKKMEMAKFRYILPVYGICREP--VGLVMEYMETGSLEKLLASE---PLPWDLRF 119 Query: 264 EICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 443 I A G+++LH A ++H D+K ANILLD + K+SDFGL+K L +H Sbjct: 120 RIIHETAVGMNFLHC-MAPPLLHLDLKPANILLDAHYHVKISDFGLAKCN-GLSHSH-DL 176 Query: 444 AVKGSFG---YLDPEYYR-RQKLTD-KSDVYSF 527 ++ G FG YL PE R + +L D K DVYSF Sbjct: 177 SMDGLFGTIAYLPPERIREKSRLFDTKHDVYSF 209
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 77.0 bits (188), Expect = 3e-14 Identities = 54/180 (30%), Positives = 91/180 (50%), Gaps = 5/180 (2%) Frame = +3 Query: 3 KVYKAVL----QDSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQN 167 +VY+ L QD VA+K S G F E ++ H H++ L G ++ Sbjct: 638 EVYRGALRLPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLEGVITKRK 697 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++++ E+ME G L + L + L+ + V + +G A G++ L + +HRD+ + Sbjct: 698 PIMIITEFMENGALDAFLKERE-DQLAPGQLVAMLLGIASGMNCLS---GHNYVHRDLAA 753 Query: 348 ANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 NIL+++NL KVSDFGL++ + D T+ + K + PE + T SDV+SF Sbjct: 754 RNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSF 813
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 77.0 bits (188), Expect = 3e-14 Identities = 53/177 (29%), Positives = 87/177 (49%), Gaps = 3/177 (1%) Frame = +3 Query: 6 VYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 VYK V + + + + + FR E+ +L RH +++ +GY + N + +V Sbjct: 96 VYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVT 154 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 ++ E +L HL+ + + ++I A+G+ YLH AK+IIHRD+KS NI L Sbjct: 155 QWCEGSSLYKHLHVQETK-FQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLH 210 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ---KLTDKSDVYSF 527 L K+ DFGL+ + GS ++ PE R Q + +SDVYS+ Sbjct: 211 GGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSY 267
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 76.6 bits (187), Expect = 4e-14 Identities = 50/178 (28%), Positives = 95/178 (53%), Gaps = 3/178 (1%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V++ + ++T VAVK S +F E +++ LRH L+ L C ++ + ++ Sbjct: 247 EVWEGLWNNTTPVAVKTLKPGSMDP-NDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYII 305 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E M G+L+ +L + ++V++ A G+ YL + ++ IHRD+ + N+L+ Sbjct: 306 TELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLES---RNYIHRDLAARNVLV 362 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTA---VKGSFGYLDPEYYRRQKLTDKSDVYSF 527 E+ + KV+DFGL++ ++D + + +K + PE R K + KSDV+SF Sbjct: 363 GEHNIYKVADFGLARVF-KVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSF 419
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 76.6 bits (187), Expect = 4e-14 Identities = 55/175 (31%), Positives = 89/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH+ LV L E+ + +V Sbjct: 279 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHKKLVQLYAVVSEE-PIYIV 336 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 337 IEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 393 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 394 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 447
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 76.3 bits (186), Expect = 5e-14 Identities = 48/152 (31%), Positives = 81/152 (53%), Gaps = 4/152 (2%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYG----SDMPPLS 248 ++FR E+E+ S LRH +L L GY ++ + L+ EY+ G L HL G +D+ Sbjct: 152 KQFRREVEIQSSLRHPNLTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRSHFNDVVASY 211 Query: 249 WKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQ 428 + ++ A L Y+H ++I+HRD+K NI++ N K++DFG S P+ + Sbjct: 212 YVYQM------ADALDYMH---ERNILHRDIKPENIIIGFNNTIKLTDFGWSVITPKGSK 262 Query: 429 THVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + G+ YL PE R ++ +K DV++ Sbjct: 263 ---RKTLCGTVDYLSPELIRSREYNEKVDVWA 291
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 76.3 bits (186), Expect = 5e-14 Identities = 57/182 (31%), Positives = 92/182 (50%), Gaps = 8/182 (4%) Frame = +3 Query: 6 VYKAVLQDST----KVAVKRGNQKSHQG-LREFRTEIELLSGLRHRHLVSLIGYC-DEQN 167 VY L D+ AVK N+ + G + +F TE ++ H +++SL+G C + Sbjct: 1093 VYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG 1152 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++V YM+ G L++ + P + K + + A+G+ YL + K +HRD+ + Sbjct: 1153 SPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLAS---KKFVHRDLAA 1208 Query: 348 ANILLDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 N +LDEN KV+DFGL++ E H T K ++ E + QK T KSDV+ Sbjct: 1209 RNCMLDENFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVW 1268 Query: 522 SF 527 SF Sbjct: 1269 SF 1270
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 76.3 bits (186), Expect = 5e-14 Identities = 49/148 (33%), Positives = 79/148 (53%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 ++ R EIE+ S LRH++++ L G+ ++ + L+ E+ +G L HL + S + Sbjct: 132 KQVRREIEIQSNLRHKNILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKR--FSEEVA 189 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVS 440 + A L YLH K +IHRD+K NILL + K+SDFG S P ++ Sbjct: 190 SKYIFQMANALSYLH---KKHVIHRDIKPENILLGIDGEIKLSDFGWSVHAP----SNRR 242 Query: 441 TAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 T + G+ YL PE ++ T+K D++S Sbjct: 243 TTLCGTLDYLPPEMVEGKEHTEKVDLWS 270
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 76.3 bits (186), Expect = 5e-14 Identities = 49/170 (28%), Positives = 91/170 (53%), Gaps = 1/170 (0%) Frame = +3 Query: 18 VLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLI-GYCDEQNEMILVYEYM 194 + ++ K+A+K+ + + EI ++ +H+++V+ + Y NE+ ++ EYM Sbjct: 700 IKDNNRKIAIKQMDLDAQPRKELIINEILVMKDSQHKNIVNFLDSYLIGDNELWVIMEYM 759 Query: 195 EKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENL 374 + G+L + +D L+ K+ IC +GL +LH K IIHRD+KS N+LLD Sbjct: 760 QGGSLTEIIENNDFK-LNEKQIATICFETLKGLQHLHK---KHIIHRDIKSDNVLLDAYG 815 Query: 375 MAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 K++DFG DQ + + G+ ++ PE ++++ +K DV+S Sbjct: 816 NVKITDFGF--CAKLTDQRNKRATMVGTPYWMAPEVVKQKEYDEKVDVWS 863
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 76.3 bits (186), Expect = 5e-14 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 282 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIV 339 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 340 TEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 396 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 397 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 450
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 76.3 bits (186), Expect = 5e-14 Identities = 53/175 (30%), Positives = 89/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +VY+ + +ST VAVK + Q F E +++ LRH L+ L C + + ++ Sbjct: 108 EVYQGLWNNSTPVAVKTLKAGTMQPAA-FLAEAQIMKKLRHPKLIQLYAVCTQGEPVYII 166 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E M KG+L +L G + L + +++ A G+ YL + IHRD+ + NIL+ Sbjct: 167 TELMSKGSLLDYLQG-EAGALKLPQLIDMAAQVAAGMAYLE---LHNYIHRDLAARNILV 222 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +N + KV+DFGL++ D + + K + PE + + KSDV+SF Sbjct: 223 GDNNICKVADFGLARLIVS-DDYNATEGAKFPIKWTAPEAALFNRFSIKSDVWSF 276
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 75.9 bits (185), Expect = 6e-14 Identities = 57/182 (31%), Positives = 92/182 (50%), Gaps = 7/182 (3%) Frame = +3 Query: 3 KVYKAVLQDST-----KVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQ 164 +VYK +L+ S+ VA+K + R +F E ++ H +++ L G + Sbjct: 626 EVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKY 685 Query: 165 NEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 M+++ EYME G L L D S + V + G A G+ YL + +HRD+ Sbjct: 686 KPMMIITEYMENGALDKFLREKD-GEFSVLQLVGMLRGIAAGMKYLAN---MNYVHRDLA 741 Query: 345 SANILLDENLMAKVSDFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 + NIL++ NL+ KVSDFGLS+ + + T+ ++ K + PE +K T SDV+ Sbjct: 742 ARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVW 801 Query: 522 SF 527 SF Sbjct: 802 SF 803
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 75.9 bits (185), Expect = 6e-14 Identities = 55/180 (30%), Positives = 90/180 (50%), Gaps = 5/180 (2%) Frame = +3 Query: 3 KVYKAVL----QDSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQN 167 +VY+ L QD VA+K S G F E ++ H H++ L G ++ Sbjct: 637 EVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRK 696 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++++ E+ME G L + L + L + V + G A G++YL + +HRD+ + Sbjct: 697 PIMIITEFMENGALDAFLRERE-DQLVPGQLVAMLQGIASGMNYLSN---HNYVHRDLAA 752 Query: 348 ANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 NIL+++NL KVSDFGL++ + D T+ + K + PE + T SDV+SF Sbjct: 753 RNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSF 812
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 75.9 bits (185), Expect = 6e-14 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 279 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIV 336 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 337 IEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 393 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 394 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 447
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 75.9 bits (185), Expect = 6e-14 Identities = 56/182 (30%), Positives = 92/182 (50%), Gaps = 7/182 (3%) Frame = +3 Query: 3 KVYKAVLQDST-----KVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQ 164 +VYK L+ S+ VA+K + R +F +E ++ H +++ L G + Sbjct: 627 EVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIPLEGVVSKY 686 Query: 165 NEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVK 344 M+++ EYME G L L D S + V + G A G+ YL + +HRD+ Sbjct: 687 KPMMIITEYMENGALDKFLREKD-GEFSVLQLVGMLRGIASGMKYLAN---MNYVHRDLA 742 Query: 345 SANILLDENLMAKVSDFGLSKT-GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 + NIL++ NL+ KVSDFGLS+ + + T+ ++ K + PE +K T SDV+ Sbjct: 743 ARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVW 802 Query: 522 SF 527 S+ Sbjct: 803 SY 804
>FGFR4_RAT (Q498D6) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) Length = 800 Score = 75.9 bits (185), Expect = 6e-14 Identities = 49/183 (26%), Positives = 92/183 (50%), Gaps = 15/183 (8%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEK 200 Q ST + S + L + +E+E++ + RH+++++L+G C ++ + ++ EY K Sbjct: 494 QTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAK 553 Query: 201 GTLKSHLYGSDMP--------------PLSWKKRVEICIGAARGLHYLHTGFAKSIIHRD 338 G L+ L P PLS+ V ARG+ YL + + IHRD Sbjct: 554 GNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLES---RKCIHRD 610 Query: 339 VKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDV 518 + + N+L+ E+ + K++DFGL++ +D ++ + ++ PE + T +SDV Sbjct: 611 LAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDV 670 Query: 519 YSF 527 +SF Sbjct: 671 WSF 673
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 75.9 bits (185), Expect = 6e-14 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 287 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIV 344 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 345 TEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVER---MNYVHRDLRAANILV 401 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 402 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 455
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 75.5 bits (184), Expect = 8e-14 Identities = 51/165 (30%), Positives = 85/165 (51%), Gaps = 1/165 (0%) Frame = +3 Query: 36 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 215 +VA+K+ +++ T+I+ L L+H ++++ G C + ++ EY G L Sbjct: 191 EVAIKKVREQNE-------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 243 Query: 216 HLY-GSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSD 392 L G + P + V+ G A G++YLH IIHRD+KS N+L+ K+SD Sbjct: 244 VLRAGRKITP---RLLVDWSTGIASGMNYLHL---HKIIHRDLKSPNVLVTHTDAVKISD 297 Query: 393 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 FG SK EL + G+ +L PE R + +++K D++SF Sbjct: 298 FGTSK---ELSDKSTKMSFAGTVAWLAPEVIRNEPVSEKVDIWSF 339
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 75.5 bits (184), Expect = 8e-14 Identities = 43/138 (31%), Positives = 76/138 (55%), Gaps = 4/138 (2%) Frame = +3 Query: 3 KVYKAVLQDSTKV----AVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNE 170 KV +A + S +V ++++ K Q + R EIE++S L H H++S+ + +++ Sbjct: 68 KVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDK 127 Query: 171 MILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 ++++ EY KG L ++ S+ LS ++ +HY H ++HRD+K Sbjct: 128 IVIIMEYASKGELYDYI--SERRRLSERETRHFFRQIVSAVHYCH---KNGVVHRDLKLE 182 Query: 351 NILLDENLMAKVSDFGLS 404 NILLD+N K++DFGLS Sbjct: 183 NILLDDNCNIKIADFGLS 200
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 75.5 bits (184), Expect = 8e-14 Identities = 56/180 (31%), Positives = 99/180 (55%), Gaps = 5/180 (2%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLRE---FRTEIELLSGLRHRHLVSLIGYC-DEQNE 170 KVYK ++ VA+KR ++ + F E+ +L L H ++ +G C ++ ++ Sbjct: 577 KVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQ 635 Query: 171 MILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 +V +Y+ G+L S L+ L + ++ I + A+G+ YLH + IIHRD+ S Sbjct: 636 FAIVTQYISGGSLFSLLH-EQKRILDLQSKLIIAVDVAKGMEYLHN-LTQPIIHRDLNSH 693 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRR-QKLTDKSDVYSF 527 NILL E+ A V+DFG S+ LD+ ++ T G+ ++ PE + + + T K+DV+S+ Sbjct: 694 NILLYEDGHAVVADFGESRFLQSLDEDNM-TKQPGNLRWMAPEVFTQCTRYTIKADVFSY 752
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 75.5 bits (184), Expect = 8e-14 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 276 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAMVSEE-PIYIV 333 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + VE+ A G+ Y+ + +HRD+++ANIL+ Sbjct: 334 IEYMSKGSLLDFLKGEMGKYLRLPQLVEMAAQIASGMAYVER---MNYVHRDLRAANILV 390 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T + + PE + T KSDV+SF Sbjct: 391 GENLVCKVADFGLARLIEDNEYT-ARPGARFPVKWTAPEAALYGRFTIKSDVWSF 444
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 75.5 bits (184), Expect = 8e-14 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 279 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIV 336 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 337 TEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 393 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 394 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 447
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 75.5 bits (184), Expect = 8e-14 Identities = 50/175 (28%), Positives = 88/175 (50%), Gaps = 1/175 (0%) Frame = +3 Query: 6 VYKAV-LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 VY+A + +VAVK+ L + E E+LS L HR+++ G E +V Sbjct: 30 VYRAKWISQDKEVAVKK--------LLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIV 81 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EY G+L ++ + + + + A+G+HYLH +IHRD+KS N+++ Sbjct: 82 TEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVI 141 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + + K+ DFG S+ TH+S + G+F ++ PE + +++ D YS+ Sbjct: 142 AADGVLKICDFGASRF--HNHTTHMS--LVGTFPWMAPEVIQSLPVSETCDTYSY 192
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 75.5 bits (184), Expect = 8e-14 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 282 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIV 339 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 340 TEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVDR---MNYVHRDLRAANILV 396 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 397 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 450
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 75.5 bits (184), Expect = 8e-14 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 279 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIV 336 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 337 TEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 393 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 394 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 447
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 75.5 bits (184), Expect = 8e-14 Identities = 61/199 (30%), Positives = 93/199 (46%), Gaps = 24/199 (12%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQ----GLREFRTEIELLSGLRHRHLVSLIGYCDEQNE 170 +VY+A Q +VAVK Q Q R E L + LRH +++ L G C +Q Sbjct: 137 QVYRATWQGQ-EVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPH 195 Query: 171 MILVYEYMEKGTLKSHLYGSDMPP------------LSWKKRVEICIGAARGLHYLHTGF 314 + LV E+ G L L ++ P + V + ARG+ YLH Sbjct: 196 LCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEA 255 Query: 315 AKSIIHRDVKSANILLDE--------NLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYL 470 I+HRD+KS+NILL E N K++DFGL++ T +STA G++ ++ Sbjct: 256 FVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHR--TTKMSTA--GTYAWM 311 Query: 471 DPEYYRRQKLTDKSDVYSF 527 PE + + SD++S+ Sbjct: 312 APEVIKSSLFSKGSDIWSY 330
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 75.5 bits (184), Expect = 8e-14 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 279 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIV 336 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 337 TEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 393 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 394 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 447
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 75.5 bits (184), Expect = 8e-14 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 279 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIV 336 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 337 TEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 393 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 394 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 447
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 75.5 bits (184), Expect = 8e-14 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 279 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIV 336 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 337 TEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 393 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 394 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 447
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 75.1 bits (183), Expect = 1e-13 Identities = 49/176 (27%), Positives = 87/176 (49%), Gaps = 1/176 (0%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +VY+AV + + ++ L++F E ++ ++H +LV LIG C + ++ Sbjct: 384 EVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYII 443 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E+M G L L + L + + A G+ YL +++ IHRD+ + N L+ Sbjct: 444 TEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLE---SRNYIHRDLAARNCLV 500 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTA-VKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +N + KV+DFGL++ D T+ + A K + PE K + KSDV++F Sbjct: 501 GDNKLVKVADFGLARL--MRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAF 554
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 75.1 bits (183), Expect = 1e-13 Identities = 55/179 (30%), Positives = 91/179 (50%), Gaps = 12/179 (6%) Frame = +3 Query: 27 DSTKVAVKRGNQKSHQGLREFRT----EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYM 194 D +VA+K +Q ++ R E +L L+H ++ +L G C ++ LV EY Sbjct: 162 DGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVC-LNTKLCLVMEYA 220 Query: 195 EKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENL 374 G+L L G P + ++I ARG++YLH SIIHRD+KS+N+L+ E + Sbjct: 221 RGGSLNRILAGKIPPDVLVNWAIQI----ARGMNYLHNEAPMSIIHRDLKSSNVLIYEAI 276 Query: 375 --------MAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 K++DFGL++ E+ T +A G++ ++ PE + SDV+S+ Sbjct: 277 EGNHLQQKTLKITDFGLAR---EMYNTQRMSAA-GTYAWMPPEVISVSTYSKFSDVWSY 331
>IGF1R_XENLA (O73798) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (xIGF-1R) (xIGFR) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1358 Score = 75.1 bits (183), Expect = 1e-13 Identities = 53/185 (28%), Positives = 88/185 (47%), Gaps = 11/185 (5%) Frame = +3 Query: 6 VYKAVLQDS--TKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMI 176 + K V++D TKVA+K N+ + R EF E ++ H+V L+G + + Sbjct: 1013 IAKGVVKDEAETKVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTL 1072 Query: 177 LVYEYMEKGTLKSHLYG--------SDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIH 332 ++ E M +G LKS+L S P S KK +++ A G+ YL+ A +H Sbjct: 1073 VIMELMTRGDLKSYLRSLRPDTESNSGQPTPSLKKMIQMAGEIADGMSYLN---ANKFVH 1129 Query: 333 RDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKS 512 RD+ + N ++ E+ K+ DFG+++ E D ++ PE + T S Sbjct: 1130 RDLAARNCMVTEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNS 1189 Query: 513 DVYSF 527 DV+SF Sbjct: 1190 DVWSF 1194
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 75.1 bits (183), Expect = 1e-13 Identities = 54/175 (30%), Positives = 87/175 (49%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V++ + S VAVK + + L + EIE L LRH L+ L C + +V Sbjct: 247 EVWEGLWLGSIPVAVKV-IKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIV 305 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E M KG L+ +L S+ LS + A G+ YL + ++HRD+ + N+L+ Sbjct: 306 TELMGKGNLQVYLGSSEGKALSLPHLLGFACQVAEGMSYLE---ERRVVHRDLAARNVLV 362 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ++L KV+DFGL++ + D S+ K + PE + + KSDV+SF Sbjct: 363 GDDLTCKVADFGLARLLKD-DVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSF 416
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 75.1 bits (183), Expect = 1e-13 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 279 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVRLYAVVSEE-PIYIV 336 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 337 TEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 393 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 394 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 447
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 75.1 bits (183), Expect = 1e-13 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 278 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIV 335 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 336 TEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 392 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 393 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 446
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 75.1 bits (183), Expect = 1e-13 Identities = 54/175 (30%), Positives = 86/175 (49%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +TKVA+K + F E +++ L+H LV L E+ + +V Sbjct: 283 EVWMGTWNGNTKVAIKT-LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIV 340 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L + L V++ ARG+ Y+ + IHRD++SANIL+ Sbjct: 341 TEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVARGMAYIER---MNYIHRDLRSANILV 397 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 L+ K++DFGL++ + + T K + PE + T KSDV+SF Sbjct: 398 GNGLICKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 451
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 74.7 bits (182), Expect = 1e-13 Identities = 52/175 (29%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V++ + S VA+K + ++ L + EI+ L GLRH L+ L C + +V Sbjct: 243 EVWEGLWLGSLPVAIKV-IKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIV 301 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E M KG L++ L + L + A G+ YL + ++HRD+ + N+L+ Sbjct: 302 TELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEE---QRVVHRDLAARNVLV 358 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 D+ L KV+DFGL++ + D S++ K + PE + + KSDV+SF Sbjct: 359 DDGLACKVADFGLARLLKD-DIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSF 412
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 74.7 bits (182), Expect = 1e-13 Identities = 55/175 (31%), Positives = 86/175 (49%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ D TKVAVK Q S F E L+ L+H+ LV L Q + ++ Sbjct: 257 EVWMGYYNDHTKVAVKSLKQGS-MSPDAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYII 314 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYME G+L L L+ K +++ A G+ ++ ++ IHRD+++ANIL+ Sbjct: 315 TEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEE---RNYIHRDLRAANILV 371 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + L K++DFGL++ + + T K + PE T KSDV+SF Sbjct: 372 SDTLSCKIADFGLARLIEDNEYT-AREGAKFPIKWTAPEAINYGTFTIKSDVWSF 425
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 74.7 bits (182), Expect = 1e-13 Identities = 50/165 (30%), Positives = 85/165 (51%), Gaps = 1/165 (0%) Frame = +3 Query: 36 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 215 +VA+K+ +++ T+I+ L L+H ++++ G C + ++ EY G L Sbjct: 191 EVAIKKVREQNE-------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 243 Query: 216 HLY-GSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSD 392 L G + P + V+ G A G++YLH IIHRD+KS N+L+ K+SD Sbjct: 244 VLRAGRKITP---RLLVDWSTGIASGMNYLHL---HKIIHRDLKSPNVLVTHTDAVKISD 297 Query: 393 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 FG SK EL + G+ ++ PE R + +++K D++SF Sbjct: 298 FGTSK---ELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF 339
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 74.7 bits (182), Expect = 1e-13 Identities = 50/175 (28%), Positives = 87/175 (49%), Gaps = 1/175 (0%) Frame = +3 Query: 6 VYKAV-LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 VY+A + +VAVK+ L + E E+LS L HR+++ G E +V Sbjct: 30 VYRAKWISQDKEVAVKK--------LLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIV 81 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EY G+L ++ + + + A+G+HYLH +IHRD+KS N+++ Sbjct: 82 TEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVI 141 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + + K+ DFG S+ TH+S + G+F ++ PE + +++ D YS+ Sbjct: 142 AADGVLKICDFGASRF--HNHTTHMS--LVGTFPWMAPEVIQSLPVSETCDTYSY 192
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 74.3 bits (181), Expect = 2e-13 Identities = 47/159 (29%), Positives = 87/159 (54%), Gaps = 1/159 (0%) Frame = +3 Query: 54 GNQKSHQGLREFR-TEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGS 230 G + + + +R+ + T+I+ L L+H ++++ G C + ++ E+ +G L L Sbjct: 179 GEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG 238 Query: 231 DMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKT 410 P++ V+ +G A G++YLH IIHRD+KS N+L+ + + K+SDFG SK Sbjct: 239 R--PVTPSLLVDWSMGIAGGMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSK- 292 Query: 411 GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 EL + G+ ++ PE R + +++K D++SF Sbjct: 293 --ELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF 329
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 74.3 bits (181), Expect = 2e-13 Identities = 47/159 (29%), Positives = 87/159 (54%), Gaps = 1/159 (0%) Frame = +3 Query: 54 GNQKSHQGLREFR-TEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGS 230 G + + + +R+ + T+I+ L L+H ++++ G C + ++ E+ +G L L Sbjct: 179 GEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG 238 Query: 231 DMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKT 410 P++ V+ +G A G++YLH IIHRD+KS N+L+ + + K+SDFG SK Sbjct: 239 R--PVTPSLLVDWSMGIAGGMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSK- 292 Query: 411 GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 EL + G+ ++ PE R + +++K D++SF Sbjct: 293 --ELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF 329
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 74.3 bits (181), Expect = 2e-13 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +TKVA+K + F E +++ LRH LV L E+ + +V Sbjct: 289 EVWMGTWNGTTKVAIKTLKPGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIV 346 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E+M KG+L L D L + V++ A G+ Y+ + IHRD+++ANIL+ Sbjct: 347 TEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILV 403 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ K++DFGL++ + + T K + PE + T KSDV+SF Sbjct: 404 GENLVCKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 457
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 74.3 bits (181), Expect = 2e-13 Identities = 47/159 (29%), Positives = 87/159 (54%), Gaps = 1/159 (0%) Frame = +3 Query: 54 GNQKSHQGLREFR-TEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGS 230 G + + + +R+ + T+I+ L L+H ++++ G C + ++ E+ +G L L Sbjct: 146 GEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG 205 Query: 231 DMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKT 410 P++ V+ +G A G++YLH IIHRD+KS N+L+ + + K+SDFG SK Sbjct: 206 R--PVTPSLLVDWSMGIAGGMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSK- 259 Query: 411 GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 EL + G+ ++ PE R + +++K D++SF Sbjct: 260 --ELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF 296
>MET_RAT (P97523) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 74.3 bits (181), Expect = 2e-13 Identities = 56/182 (30%), Positives = 91/182 (50%), Gaps = 8/182 (4%) Frame = +3 Query: 6 VYKAVLQDST----KVAVKRGNQKSH-QGLREFRTEIELLSGLRHRHLVSLIGYC-DEQN 167 VY L DS AVK N+ + + + +F TE ++ H +++SL+G C + Sbjct: 1093 VYHGTLLDSDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG 1152 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++V YM+ G L++ + P + K + + A+G+ YL +K +HRD+ + Sbjct: 1153 SPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYL---VSKKFVHRDLAA 1208 Query: 348 ANILLDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 N +LDE KV+DFGL++ E H T K ++ E + QK T KSDV+ Sbjct: 1209 RNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVW 1268 Query: 522 SF 527 SF Sbjct: 1269 SF 1270
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 74.3 bits (181), Expect = 2e-13 Identities = 48/184 (26%), Positives = 96/184 (52%), Gaps = 16/184 (8%) Frame = +3 Query: 24 QDSTKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYME 197 +++ VAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY Sbjct: 509 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 568 Query: 198 KGTLKSHLYGSDMP--------------PLSWKKRVEICIGAARGLHYLHTGFAKSIIHR 335 KG L+ +L P +++K V ARG+ YL + + IHR Sbjct: 569 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS---QKCIHR 625 Query: 336 DVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSD 515 D+ + N+L+ EN + K++DFGL++ +D +T + ++ PE + T +SD Sbjct: 626 DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD 685 Query: 516 VYSF 527 V+SF Sbjct: 686 VWSF 689
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 74.3 bits (181), Expect = 2e-13 Identities = 48/184 (26%), Positives = 96/184 (52%), Gaps = 16/184 (8%) Frame = +3 Query: 24 QDSTKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYME 197 +++ VAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY Sbjct: 509 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 568 Query: 198 KGTLKSHLYGSDMP--------------PLSWKKRVEICIGAARGLHYLHTGFAKSIIHR 335 KG L+ +L P +++K V ARG+ YL + + IHR Sbjct: 569 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS---QKCIHR 625 Query: 336 DVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSD 515 D+ + N+L+ EN + K++DFGL++ +D +T + ++ PE + T +SD Sbjct: 626 DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD 685 Query: 516 VYSF 527 V+SF Sbjct: 686 VWSF 689
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 74.3 bits (181), Expect = 2e-13 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +TKVAVK + F E +++ LRH LV L E+ + +V Sbjct: 282 EVWMGTWNGTTKVAVKT-LKPGTMSPEAFLEEAQIMKRLRHDKLVQLYAVVSEE-PIYIV 339 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E+M +G+L L D L + V++ A G+ Y+ + IHRD+++ANIL+ Sbjct: 340 TEFMSQGSLLDFLKDGDGRYLKLPQLVDMAAQIAAGMAYIER---MNYIHRDLRAANILV 396 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +NL+ K++DFGL++ + + T K + PE K T KSDV+SF Sbjct: 397 GDNLVCKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALFGKFTIKSDVWSF 450
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 74.3 bits (181), Expect = 2e-13 Identities = 48/184 (26%), Positives = 96/184 (52%), Gaps = 16/184 (8%) Frame = +3 Query: 24 QDSTKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYME 197 +++ VAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY Sbjct: 511 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 570 Query: 198 KGTLKSHLYGSDMP--------------PLSWKKRVEICIGAARGLHYLHTGFAKSIIHR 335 KG L+ +L P +++K V ARG+ YL + + IHR Sbjct: 571 KGNLREYLRARRPPGMEYSFDINRVPEEQMTFKDLVSCTYQLARGMEYLAS---QKCIHR 627 Query: 336 DVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSD 515 D+ + N+L+ EN + K++DFGL++ +D +T + ++ PE + T +SD Sbjct: 628 DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD 687 Query: 516 VYSF 527 V+SF Sbjct: 688 VWSF 691
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 74.3 bits (181), Expect = 2e-13 Identities = 50/167 (29%), Positives = 82/167 (49%), Gaps = 18/167 (10%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 + F TE++++ L H +++ IG + ++ L+ EY+E GTLK L +D P W+++ Sbjct: 371 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNAD--PFPWQQK 428 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLS------KTGPEL 422 V G A G+ YLH + IIHRD+ S N L+ + V+DFGLS + P L Sbjct: 429 VSFAKGIASGMAYLH---SMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPTL 485 Query: 423 DQTHVST------------AVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ++ V G+ ++ PE Q + D++SF Sbjct: 486 EKPSAKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGQSYDETVDIFSF 532
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 74.3 bits (181), Expect = 2e-13 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +TKVA+K + F E +++ LRH LV L E+ + +V Sbjct: 287 EVWMGTWNGTTKVAIKTLKPGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIV 344 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E+M KG+L L D L + V++ A G+ Y+ + IHRD+++ANIL+ Sbjct: 345 TEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILV 401 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ K++DFGL++ + + T K + PE + T KSDV+SF Sbjct: 402 GENLICKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 455
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 73.9 bits (180), Expect = 2e-13 Identities = 55/175 (31%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +TKVA+K + F E +++ LRH LV L E+ + +V Sbjct: 285 EVWMGTWNGTTKVAIKTLKLGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIV 342 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E+M KG+L L D L + V++ A G+ Y+ + IHRD+++ANIL+ Sbjct: 343 TEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILV 399 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ K++DFGL++ + + T K + PE + T KSDV+SF Sbjct: 400 GENLVCKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 453
>MET_PONPY (Q2IBD8) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 73.9 bits (180), Expect = 2e-13 Identities = 56/182 (30%), Positives = 91/182 (50%), Gaps = 8/182 (4%) Frame = +3 Query: 6 VYKAVLQDST----KVAVKRGNQKSHQG-LREFRTEIELLSGLRHRHLVSLIGYC-DEQN 167 VY L D+ AVK N+ + G + +F TE ++ H +++SL+G C + Sbjct: 1092 VYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG 1151 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++V YM+ G L++ + P + K + + A+G+ YL + K +HRD+ + Sbjct: 1152 SPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLAS---KKFVHRDLAA 1207 Query: 348 ANILLDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 N +LDE KV+DFGL++ E H T K ++ E + QK T KSDV+ Sbjct: 1208 RNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVW 1267 Query: 522 SF 527 SF Sbjct: 1268 SF 1269
>MET_PANTR (Q2QLF1) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 73.9 bits (180), Expect = 2e-13 Identities = 56/182 (30%), Positives = 91/182 (50%), Gaps = 8/182 (4%) Frame = +3 Query: 6 VYKAVLQDST----KVAVKRGNQKSHQG-LREFRTEIELLSGLRHRHLVSLIGYC-DEQN 167 VY L D+ AVK N+ + G + +F TE ++ H +++SL+G C + Sbjct: 1092 VYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG 1151 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++V YM+ G L++ + P + K + + A+G+ YL + K +HRD+ + Sbjct: 1152 SPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLAS---KKFVHRDLAA 1207 Query: 348 ANILLDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 N +LDE KV+DFGL++ E H T K ++ E + QK T KSDV+ Sbjct: 1208 RNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVW 1267 Query: 522 SF 527 SF Sbjct: 1268 SF 1269
>MET_HUMAN (P08581) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 73.9 bits (180), Expect = 2e-13 Identities = 56/182 (30%), Positives = 91/182 (50%), Gaps = 8/182 (4%) Frame = +3 Query: 6 VYKAVLQDST----KVAVKRGNQKSHQG-LREFRTEIELLSGLRHRHLVSLIGYC-DEQN 167 VY L D+ AVK N+ + G + +F TE ++ H +++SL+G C + Sbjct: 1092 VYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG 1151 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++V YM+ G L++ + P + K + + A+G+ YL + K +HRD+ + Sbjct: 1152 SPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLAS---KKFVHRDLAA 1207 Query: 348 ANILLDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 N +LDE KV+DFGL++ E H T K ++ E + QK T KSDV+ Sbjct: 1208 RNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVW 1267 Query: 522 SF 527 SF Sbjct: 1268 SF 1269
>MET_MICMU (Q2QL89) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 73.9 bits (180), Expect = 2e-13 Identities = 56/182 (30%), Positives = 91/182 (50%), Gaps = 8/182 (4%) Frame = +3 Query: 6 VYKAVLQDST----KVAVKRGNQKSHQG-LREFRTEIELLSGLRHRHLVSLIGYC-DEQN 167 VY L D+ AVK N+ + G + +F TE ++ H +++SL+G C + Sbjct: 1093 VYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG 1152 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++V YM+ G L++ + P + K + + A+G+ YL + K +HRD+ + Sbjct: 1153 SPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLAS---KKFVHRDLAA 1208 Query: 348 ANILLDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 N +LDE KV+DFGL++ E H T K ++ E + QK T KSDV+ Sbjct: 1209 RNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVW 1268 Query: 522 SF 527 SF Sbjct: 1269 SF 1270
>MET_CANFA (Q75ZY9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 73.9 bits (180), Expect = 2e-13 Identities = 56/182 (30%), Positives = 91/182 (50%), Gaps = 8/182 (4%) Frame = +3 Query: 6 VYKAVLQDSTK----VAVKRGNQKSHQG-LREFRTEIELLSGLRHRHLVSLIGYC-DEQN 167 VY L D+ AVK N+ + G + +F TE ++ H +++SL+G C + Sbjct: 1093 VYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG 1152 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++V YM+ G L++ + P + K + + A+G+ YL + K +HRD+ + Sbjct: 1153 SPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLAS---KKFVHRDLAA 1208 Query: 348 ANILLDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 N +LDE KV+DFGL++ E H T K ++ E + QK T KSDV+ Sbjct: 1209 RNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVW 1268 Query: 522 SF 527 SF Sbjct: 1269 SF 1270
>PTK7_CHICK (Q91048) Tyrosine-protein kinase-like 7 precursor (Kinase-like| protein) Length = 1051 Score = 73.9 bits (180), Expect = 2e-13 Identities = 54/170 (31%), Positives = 77/170 (45%), Gaps = 7/170 (4%) Frame = +3 Query: 39 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 218 V VK + Q +FR E E+ L H ++V L+G C E +V EY++ G LK Sbjct: 808 VLVKSLQTRDEQLQLDFRREAEMFGKLNHVNVVRLLGLCREAEPHYMVLEYVDLGDLKQF 867 Query: 219 LYGSDM-------PPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLM 377 L S PLS K +V +C A G+ +L G +HRD+ + N L+ Sbjct: 868 LRISKSKDESLKPQPLSTKHKVSLCTQVALGMEHLSNG---RFVHRDLAARNCLVSAQRQ 924 Query: 378 AKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 KVS LSK + H A ++ PE + + KSDV+SF Sbjct: 925 VKVSALSLSKDVYNSEYYHFRQAWI-PLRWMPPEAVLEDEFSTKSDVWSF 973
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 73.9 bits (180), Expect = 2e-13 Identities = 49/152 (32%), Positives = 81/152 (53%), Gaps = 6/152 (3%) Frame = +3 Query: 87 FRTEIELLSGLRHRHLVSLIG----YCDEQNEMILVYEYMEKGTLKSHLY-GSDMPPLSW 251 FR E + + L H +V++ Y D + +V EY++ TL+ L+ G + P Sbjct: 56 FRREAQSAASLNHPAIVAVYDTGEDYIDNVSIPYIVMEYVDGSTLRELLHSGRKLLP--- 112 Query: 252 KKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQT 431 ++ +E+ IG + L Y H I+HRD+K AN++L N KV DFG+++ + T Sbjct: 113 ERTLEMTIGILQALEYSHRA---GIVHRDIKPANVMLTRNGQVKVMDFGIARAMGDSGMT 169 Query: 432 HVST-AVKGSFGYLDPEYYRRQKLTDKSDVYS 524 T AV G+ YL PE + +++ +SD+YS Sbjct: 170 MTQTAAVIGTAQYLSPEQAKGEQVDARSDLYS 201
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 73.9 bits (180), Expect = 2e-13 Identities = 48/148 (32%), Positives = 76/148 (51%) Frame = +3 Query: 84 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRV 263 +F E +++ L H LV L G C +Q + +V E+ME+G L + L S + Sbjct: 408 DFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFL-RQRQGHFSRDMLL 466 Query: 264 EICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 443 +C G+ YL S IHRD+ + N L++E + KVSDFG+++ + DQ S+ Sbjct: 467 SMCQDVCEGMEYLE---RNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLD-DQYTSSS 522 Query: 444 AVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 K + PE + + + KSDV+SF Sbjct: 523 GAKFPVKWCPPEVFNYSRFSSKSDVWSF 550
>MET_PIG (Q2QLE0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 73.9 bits (180), Expect = 2e-13 Identities = 56/182 (30%), Positives = 91/182 (50%), Gaps = 8/182 (4%) Frame = +3 Query: 6 VYKAVLQDSTK----VAVKRGNQKSHQG-LREFRTEIELLSGLRHRHLVSLIGYC-DEQN 167 VY L D+ AVK N+ + G + +F TE ++ H +++SL+G C + Sbjct: 1092 VYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG 1151 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++V YM+ G L++ + P + K + + A+G+ YL + K +HRD+ + Sbjct: 1152 SPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLAS---KKFVHRDLAA 1207 Query: 348 ANILLDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 N +LDE KV+DFGL++ E H T K ++ E + QK T KSDV+ Sbjct: 1208 RNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVW 1267 Query: 522 SF 527 SF Sbjct: 1268 SF 1269
>MET_HORSE (Q2QLA9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 73.9 bits (180), Expect = 2e-13 Identities = 56/182 (30%), Positives = 91/182 (50%), Gaps = 8/182 (4%) Frame = +3 Query: 6 VYKAVLQDSTK----VAVKRGNQKSHQG-LREFRTEIELLSGLRHRHLVSLIGYC-DEQN 167 VY L D+ AVK N+ + G + +F TE ++ H +++SL+G C + Sbjct: 1092 VYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG 1151 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++V YM+ G L++ + P + K + + A+G+ YL + K +HRD+ + Sbjct: 1152 SPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLAS---KKFVHRDLAA 1207 Query: 348 ANILLDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 N +LDE KV+DFGL++ E H T K ++ E + QK T KSDV+ Sbjct: 1208 RNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVW 1267 Query: 522 SF 527 SF Sbjct: 1268 SF 1269
>MET_CALMO (Q2QLC0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 73.9 bits (180), Expect = 2e-13 Identities = 56/182 (30%), Positives = 91/182 (50%), Gaps = 8/182 (4%) Frame = +3 Query: 6 VYKAVLQDST----KVAVKRGNQKSHQG-LREFRTEIELLSGLRHRHLVSLIGYC-DEQN 167 VY L D+ AVK N+ + G + +F TE ++ H +++SL+G C + Sbjct: 1092 VYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG 1151 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++V YM+ G L++ + P + K + + A+G+ YL + K +HRD+ + Sbjct: 1152 SPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLAS---KKFVHRDLAA 1207 Query: 348 ANILLDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 N +LDE KV+DFGL++ E H T K ++ E + QK T KSDV+ Sbjct: 1208 RNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVW 1267 Query: 522 SF 527 SF Sbjct: 1268 SF 1269
>MET_CALJA (Q2QLG5) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 73.9 bits (180), Expect = 2e-13 Identities = 56/182 (30%), Positives = 91/182 (50%), Gaps = 8/182 (4%) Frame = +3 Query: 6 VYKAVLQDST----KVAVKRGNQKSHQG-LREFRTEIELLSGLRHRHLVSLIGYC-DEQN 167 VY L D+ AVK N+ + G + +F TE ++ H +++SL+G C + Sbjct: 1092 VYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG 1151 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++V YM+ G L++ + P + K + + A+G+ YL + K +HRD+ + Sbjct: 1152 SPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLAS---KKFVHRDLAA 1207 Query: 348 ANILLDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 N +LDE KV+DFGL++ E H T K ++ E + QK T KSDV+ Sbjct: 1208 RNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVW 1267 Query: 522 SF 527 SF Sbjct: 1268 SF 1269
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 73.9 bits (180), Expect = 2e-13 Identities = 51/165 (30%), Positives = 84/165 (50%), Gaps = 1/165 (0%) Frame = +3 Query: 36 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 215 +VA+K N+ S +F E +++ L H LV L G C ++ + +V E+ME G L + Sbjct: 295 QVAIKAINEGS-MSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLN 353 Query: 216 HLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDF 395 +L + L + + +C G+ YL IHRD+ + N L+ + K+SDF Sbjct: 354 YL-RENKGKLRKEMLLSVCQDICEGMEYLE---RNGYIHRDLAARNCLVSSTCIVKISDF 409 Query: 396 GLSKTGPELDQTHVST-AVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 G+++ LD +VS+ K + PE + K + KSDV+SF Sbjct: 410 GMTRY--VLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSF 452
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 73.9 bits (180), Expect = 2e-13 Identities = 48/160 (30%), Positives = 76/160 (47%), Gaps = 14/160 (8%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 +D VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 204 TLKSHL--YGSD------------MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDV 341 L L +G D L + + I A G+ YL ++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 342 KSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSF 461 + N L+ NL+ K+ DFG+S+ D KG F Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYREGPYQKGPF 720
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 73.6 bits (179), Expect = 3e-13 Identities = 54/175 (30%), Positives = 86/175 (49%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ + TKVAVK Q S F E L+ L+H+ LV L E+ + ++ Sbjct: 257 EVWMGYYNEHTKVAVKSLKQGS-MSPDAFLAEANLMKQLQHKRLVRLYAVVTEE-PIYII 314 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYME G+L L L+ K +++ G+ +L ++ IHRD+++ANIL+ Sbjct: 315 TEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIVEGMAFLEE---RNYIHRDLRAANILV 371 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + L K++DFGL++ + + T K + PE T KSDV+SF Sbjct: 372 SDTLSCKIADFGLARLIEDNEYT-AREGAKFPIKWTAPEAINYGTFTIKSDVWSF 425
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 73.6 bits (179), Expect = 3e-13 Identities = 48/151 (31%), Positives = 79/151 (52%), Gaps = 3/151 (1%) Frame = +3 Query: 84 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL--YGSDMPPLSWKK 257 EF E + + L H LV G C ++ + +V EY+ G L ++L +G + P + Sbjct: 456 EFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEP---SQ 512 Query: 258 RVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV 437 +E+C G+ +L + IHRD+ + N L+D +L KVSDFG+++ LD +V Sbjct: 513 LLEMCYDVCEGMAFLES---HQFIHRDLAARNCLVDRDLCVKVSDFGMTRY--VLDDQYV 567 Query: 438 ST-AVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 S+ K + PE + K + KSDV++F Sbjct: 568 SSVGTKFPVKWSAPEVFHYFKYSSKSDVWAF 598
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 73.6 bits (179), Expect = 3e-13 Identities = 54/175 (30%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +T+VA+K + F E +++ LRH LV L E+ + +V Sbjct: 278 EVWMGTWNGTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIV 335 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EY+ KG+L L G L + V++ A G+ Y+ + +HRD+++ANIL+ Sbjct: 336 TEYISKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 392 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 ENL+ KV+DFGL++ + + T K + PE + T KSDV+SF Sbjct: 393 GENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 446
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 73.6 bits (179), Expect = 3e-13 Identities = 50/174 (28%), Positives = 86/174 (49%), Gaps = 1/174 (0%) Frame = +3 Query: 6 VYKAVLQDSTKV-AVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 VYKA+ + + +V A+K ++ + L + EI LL L H ++V G+ + E+ ++ Sbjct: 39 VYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYIL 98 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EY G+L+ L LS + GL YLH + +IHRD+K+ANILL Sbjct: 99 LEYCANGSLR-RLISRSSTGLSENESKTYVTQTLLGLKYLH---GEGVIHRDIKAANILL 154 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + K++DFG+S + + G+ ++ PE + + SD++S Sbjct: 155 SADNTVKLADFGVSTI-----VNSSALTLAGTLNWMAPEILGNRGASTLSDIWS 203
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 73.2 bits (178), Expect = 4e-13 Identities = 55/170 (32%), Positives = 86/170 (50%), Gaps = 3/170 (1%) Frame = +3 Query: 27 DSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 D+T VAVK + L+ +F E +L H ++V LIG C ++ + +V E ++ G Sbjct: 294 DNTPVAVKSCRETLPPELKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGG 353 Query: 204 TLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAK 383 S L S P L K+ +++ AA G+ YL + K IHRD+ + N L+ E K Sbjct: 354 DFLSFLR-SKGPHLKMKELIKMMENAAAGMEYLES---KHCIHRDLAARNCLVTEKNTLK 409 Query: 384 VSDFGLSKTGPELDQTHVSTAVKGSF--GYLDPEYYRRQKLTDKSDVYSF 527 +SDFG+S+ E D + ST + PE + + +SDV+SF Sbjct: 410 ISDFGMSR--QEEDGVYASTGGMKQIPVKWTAPEALNYGRYSSESDVWSF 457
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) Length = 813 Score = 73.2 bits (178), Expect = 4e-13 Identities = 49/184 (26%), Positives = 98/184 (53%), Gaps = 16/184 (8%) Frame = +3 Query: 24 QDSTKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYME 197 ++S VAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY Sbjct: 499 KESVTVAVKMLKDNATEKDLADLVSEMEMMKMIGKHKNIINLLGACTQGGTLYVIVEYAA 558 Query: 198 KGTLKSHL---------YGSDMP-----PLSWKKRVEICIGAARGLHYLHTGFAKSIIHR 335 KG L+ +L Y D+ +++K V ARG+ YL + + IHR Sbjct: 559 KGNLRQYLRARRPLEMEYSFDVTRVPDEQMTFKDLVSCTYQIARGMEYLAS---QKCIHR 615 Query: 336 DVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSD 515 D+ + N+L+ EN + K++DFGL++ +D ++ + ++ PE + T +SD Sbjct: 616 DLAARNVLVTENNVMKIADFGLARDVNNIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSD 675 Query: 516 VYSF 527 V+SF Sbjct: 676 VWSF 679
>LIMK1_DROME (Q8IR79) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (dLIMK)| Length = 1257 Score = 73.2 bits (178), Expect = 4e-13 Identities = 51/155 (32%), Positives = 81/155 (52%), Gaps = 3/155 (1%) Frame = +3 Query: 3 KVYKAVLQDSTKVAV-KRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 KV+K + S +V V K ++ + R F E+ +L L HRH++ IG + ++ + Sbjct: 414 KVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHM 473 Query: 180 VYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 V EY+ G LK L L W +RV + A G+ YLH + +IIHRD+ S N L Sbjct: 474 VTEYVAGGCLK-ELIHDPAQVLPWPQRVRLARDIACGMSYLH---SMNIIHRDLNSMNCL 529 Query: 360 LDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGS 458 + E+ V+DFGL+++ P L +++ GS Sbjct: 530 VREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGS 564
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 73.2 bits (178), Expect = 4e-13 Identities = 58/178 (32%), Positives = 91/178 (51%), Gaps = 7/178 (3%) Frame = +3 Query: 12 KAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEY 191 K V+ DS V + + L EI LL L H H+V +G + + + EY Sbjct: 423 KQVILDS----VSESKDRHAKLLDALAGEIALLQELSHEHIVQYLGSNLNSDHLNIFLEY 478 Query: 192 MEKGTLKSHL--YGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 + G++ L YGS L K ++ + +GL YLH+ + I+HRD+K ANIL+D Sbjct: 479 VPGGSVAGLLTMYGSFEETLV-KNFIKQTL---KGLEYLHS---RGIVHRDIKGANILVD 531 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVST-----AVKGSFGYLDPEYYRRQKLTDKSDVYS 524 K+SDFG+SK EL+ T T + +GS ++ PE ++ T+K+D++S Sbjct: 532 NKGKIKISDFGISKK-LELNSTSTKTGGARPSFQGSSFWMAPEVVKQTMHTEKTDIWS 588
>INSR_MOUSE (P15208) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1372 Score = 73.2 bits (178), Expect = 4e-13 Identities = 50/174 (28%), Positives = 83/174 (47%), Gaps = 9/174 (5%) Frame = +3 Query: 33 TKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 209 T+VAVK N+ + R EF E ++ G H+V L+G + M++V E M G L Sbjct: 1042 TRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPMLVVMELMAHGDL 1101 Query: 210 KSHL--------YGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 KSHL PP + ++ +++ A G+ YL+ AK +HRD+ + N ++ Sbjct: 1102 KSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLN---AKKFVHRDLAARNCMVA 1158 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + K+ DFG+++ E D ++ PE + T SD++SF Sbjct: 1159 HDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSF 1212
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 73.2 bits (178), Expect = 4e-13 Identities = 48/148 (32%), Positives = 75/148 (50%) Frame = +3 Query: 84 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRV 263 +F E +++ L H LV L G C +Q + +V E+ME+G L + L S + Sbjct: 409 DFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFL-RQRQGHFSRDVLL 467 Query: 264 EICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 443 +C G+ YL S IHRD+ + N L+ E + KVSDFG+++ + DQ S+ Sbjct: 468 SMCQDVCEGMEYLE---RNSFIHRDLAARNCLVSEAGVVKVSDFGMARYFLD-DQYTSSS 523 Query: 444 AVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 K + PE + + + KSDV+SF Sbjct: 524 GAKFPVKWCPPEVFNYSRFSSKSDVWSF 551
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 73.2 bits (178), Expect = 4e-13 Identities = 46/157 (29%), Positives = 85/157 (54%), Gaps = 2/157 (1%) Frame = +3 Query: 60 QKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL--YGSD 233 +K+ +RE E++LL L H ++V +G E + + ++ E++ G++ S L +GS Sbjct: 109 EKTQGHIRELEEEVQLLKNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSF 168 Query: 234 MPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTG 413 P+ ++ +G L YLH I+HRD+K ANIL+D +++DFG SK Sbjct: 169 PEPVIIMYTKQLLLG----LEYLHNN---GIMHRDIKGANILVDNKGCIRLADFGASKKV 221 Query: 414 PELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 EL + + ++KG+ ++ PE + + +D++S Sbjct: 222 VELATVNGAKSMKGTPYWMAPEVILQTGHSFSADIWS 258
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 72.8 bits (177), Expect = 5e-13 Identities = 50/159 (31%), Positives = 82/159 (51%), Gaps = 10/159 (6%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 R+F +E ++ H +++ L G + ++++ EYME G+L + L +D + + Sbjct: 39 RDFLSEASIMGQFDHPNIIRLEGVVTKCKPVMIITEYMENGSLDAFLRKND-GRFTVIQL 97 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK----------T 410 V I G A G+ YL S +HRD+ + NIL++ NL+ KVSDFG+S+ T Sbjct: 98 VGILRGIASGMKYLSD---MSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEEDPDAAYT 154 Query: 411 GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 E+ T+ S K + PE +K T SDV+S+ Sbjct: 155 TREITGTYQSQGGKIPIRWTAPEAITYRKFTSASDVWSY 193
>MET_MOUSE (P16056) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1379 Score = 72.8 bits (177), Expect = 5e-13 Identities = 55/182 (30%), Positives = 91/182 (50%), Gaps = 8/182 (4%) Frame = +3 Query: 6 VYKAVLQDST----KVAVKRGNQKSH-QGLREFRTEIELLSGLRHRHLVSLIGYC-DEQN 167 VY L D+ AVK N+ + + + +F TE ++ H +++SL+G C + Sbjct: 1090 VYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG 1149 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++V YM+ G L++ + P + K + + A+G+ YL + K +HRD+ + Sbjct: 1150 SPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLAS---KKFVHRDLAA 1205 Query: 348 ANILLDENLMAKVSDFGLSKT--GPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 N +LDE KV+DFGL++ E H T K ++ E + QK T KSDV+ Sbjct: 1206 RNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVW 1265 Query: 522 SF 527 SF Sbjct: 1266 SF 1267
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 72.8 bits (177), Expect = 5e-13 Identities = 56/170 (32%), Positives = 85/170 (50%), Gaps = 3/170 (1%) Frame = +3 Query: 27 DSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 203 D+T VAVK + L+ +F E +L H ++V LIG C ++ + +V E ++ G Sbjct: 634 DNTPVAVKSCRETLPPELKAKFLQEARILKQCNHPNIVRLIGVCTQKQPIYIVMELVQGG 693 Query: 204 TLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAK 383 S L S P L KK +++ AA G+ YL + K IHRD+ + N L+ E K Sbjct: 694 DFLSFLR-SKGPRLKMKKLIKMMENAAAGMEYLES---KHCIHRDLAARNCLVTEKNTLK 749 Query: 384 VSDFGLSKTGPELDQTHVSTAVKGSF--GYLDPEYYRRQKLTDKSDVYSF 527 +SDFG+S+ E D + ST + PE + +SDV+SF Sbjct: 750 ISDFGMSR--QEEDGVYASTGGMKQIPVKWTAPEALNYGWYSSESDVWSF 797
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 72.8 bits (177), Expect = 5e-13 Identities = 53/175 (30%), Positives = 85/175 (48%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +TKVA+K + F E +++ L+H LV L E+ + +V Sbjct: 283 EVWMGTWNGNTKVAIKT-LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIV 340 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L + L V++ A G+ Y+ + IHRD++SANIL+ Sbjct: 341 TEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSANILV 397 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 L+ K++DFGL++ + + T K + PE + T KSDV+SF Sbjct: 398 GNGLICKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 451
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 72.8 bits (177), Expect = 5e-13 Identities = 42/138 (30%), Positives = 75/138 (54%), Gaps = 4/138 (2%) Frame = +3 Query: 3 KVYKAVLQDSTKV----AVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNE 170 KV +A + S +V ++++ K + R EIE++S L H H++S+ + +++ Sbjct: 69 KVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYEVFENKDK 128 Query: 171 MILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 ++++ EY KG L ++ S+ LS ++ +HY H ++HRD+K Sbjct: 129 IVIIMEYASKGELYDYI--SERRRLSERETRHFFRQIVSAVHYCH---KNGVVHRDLKLE 183 Query: 351 NILLDENLMAKVSDFGLS 404 NILLD+N K++DFGLS Sbjct: 184 NILLDDNCNIKIADFGLS 201
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 72.4 bits (176), Expect = 7e-13 Identities = 40/109 (36%), Positives = 63/109 (57%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 + F TE++++ L H +++ IG + ++ L+ EY+E GTLK L M P W+++ Sbjct: 371 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFL--RSMDPFPWQQK 428 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 407 V G A G+ YLH + IIHRD+ S N L+ + V+DFGLS+ Sbjct: 429 VRFAKGIASGMAYLH---SMCIIHRDLNSHNCLIKLDKTVVVADFGLSR 474
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 72.4 bits (176), Expect = 7e-13 Identities = 44/164 (26%), Positives = 81/164 (49%), Gaps = 15/164 (9%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL------------- 221 R+F E E+L+ + H ++V+ G C E ++ ++++E+ME G L +L Sbjct: 550 RDFEREAEMLATIEHANIVTFYGVCTESDQWMMIFEFMENGDLNKYLRMHGPDAAFLKDR 609 Query: 222 --YGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDF 395 SD L+ ++ ++I + A + YL + +HRD+ + N L+ +L+ K+ DF Sbjct: 610 DSMDSDEGQLTREQLMKIVLQIASAMEYL---ALQHFVHRDLATRNCLVGCDLVVKLGDF 666 Query: 396 GLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 G+S+ D V ++ PE + T +SDV+SF Sbjct: 667 GMSRDVYTTDYYRVEGTAMLPVRWMPPESIIYRTFTTESDVWSF 710
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 72.4 bits (176), Expect = 7e-13 Identities = 58/183 (31%), Positives = 95/183 (51%), Gaps = 8/183 (4%) Frame = +3 Query: 3 KVYKAVLQDSTK----VAVKRGNQK-SHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQN 167 +VYK L+ +K VA+K S + R+F +E ++ H +++ L G + Sbjct: 550 EVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSR 609 Query: 168 EMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKS 347 ++++ E+ME G L S L +D + + V + G A G+ YL + +HRD+ + Sbjct: 610 PVMIITEFMENGALDSFLRQND-GQFTVIQLVGMLRGIAAGMKYLSE---MNYVHRDLAA 665 Query: 348 ANILLDENLMAKVSDFGLSK--TGPELDQTHVST-AVKGSFGYLDPEYYRRQKLTDKSDV 518 NIL++ NL+ KVSDFGLS+ D T+ S+ K + PE R +K T SDV Sbjct: 666 RNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIRYRKFTSASDV 725 Query: 519 YSF 527 +S+ Sbjct: 726 WSY 728
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 72.4 bits (176), Expect = 7e-13 Identities = 49/155 (31%), Positives = 81/155 (52%), Gaps = 6/155 (3%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 REF +E ++ H +++ L G + +++V E+ME G+L S L + S + Sbjct: 681 REFLSEASIMGQFEHPNVIHLEGVVTKSRPVMIVTEFMENGSLDSFLRQKE-GQFSVLQL 739 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVS 440 V + G A G+ YL + +HRD+ + NIL++ NL+ KVSDFGLS+ L+ + Sbjct: 740 VGMLRGIAAGMRYLSD---MNYVHRDLAARNILVNSNLVCKVSDFGLSRF---LEDDASN 793 Query: 441 TAVKGSFG------YLDPEYYRRQKLTDKSDVYSF 527 G+ G + PE + +K T SDV+S+ Sbjct: 794 PTYTGALGCKIPIRWTAPEAVQYRKFTSSSDVWSY 828
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 72.4 bits (176), Expect = 7e-13 Identities = 47/148 (31%), Positives = 76/148 (51%), Gaps = 4/148 (2%) Frame = +3 Query: 96 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICI 275 E + ++ +H+VS+ G C + + +V E+M G+L+ L L WK R I Sbjct: 71 EAAKMKKIKFQHIVSIYGVCKQP--LGIVMEFMANGSLEKVL---STHSLCWKLRFRIIH 125 Query: 276 GAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV--STAV 449 + +++LH+ ++H D+K NILLD N+ K+SDFGLSK + + +A+ Sbjct: 126 ETSLAMNFLHS-IKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSAL 184 Query: 450 KGSFGYLDPEYYRRQKLT--DKSDVYSF 527 +G Y+ PE + K DVYSF Sbjct: 185 RGMLSYIPPEMFLESNKAPGPKYDVYSF 212
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 72.4 bits (176), Expect = 7e-13 Identities = 53/175 (30%), Positives = 85/175 (48%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +TKVA+K + F E +++ L+H LV L E+ + +V Sbjct: 280 EVWLGTWNGNTKVAIKT-LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIV 337 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L + L V++ A G+ Y+ + IHRD++SANIL+ Sbjct: 338 TEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSANILV 394 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 L+ K++DFGL++ + + T K + PE + T KSDV+SF Sbjct: 395 GNGLICKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 448
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 72.0 bits (175), Expect = 9e-13 Identities = 54/175 (30%), Positives = 85/175 (48%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ TKVAVK Q S F E L+ L+H+ LV L Q + ++ Sbjct: 257 EVWMGYYNGHTKVAVKSLKQGS-MSPDAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYII 314 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYME G+L L L+ K +++ A G+ ++ ++ IHRD+++ANIL+ Sbjct: 315 TEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEE---RNYIHRDLRAANILV 371 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + L K++DFGL++ + + T K + PE T KSDV+SF Sbjct: 372 SDTLSCKIADFGLARLIEDNEYT-AREGAKFPIKWTAPEAINYGTFTIKSDVWSF 425
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 72.0 bits (175), Expect = 9e-13 Identities = 48/179 (26%), Positives = 93/179 (51%), Gaps = 16/179 (8%) Frame = +3 Query: 39 VAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 212 VAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY KG L+ Sbjct: 499 VAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLR 558 Query: 213 SHLYGSDMP--------------PLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 +L P L++K V ARG+ YL + + IHRD+ + Sbjct: 559 EYLRARRPPGMDYSFDTCKLPEEQLTFKDLVSCAYQVARGMEYLAS---QKCIHRDLAAR 615 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 N+L+ E+ + K++DFGL++ +D +T + ++ PE + T +SDV+SF Sbjct: 616 NVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 674
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 72.0 bits (175), Expect = 9e-13 Identities = 46/150 (30%), Positives = 74/150 (49%) Frame = +3 Query: 78 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKK 257 L EF E ++ L H++LV L+G C + ++ E+M G L +L +D L Sbjct: 349 LHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPII 408 Query: 258 RVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV 437 V++ A G+ YL A+ IHRD+ + N L+ E+ + K++DFGL++ E D Sbjct: 409 LVQMASQIASGMSYLE---ARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKE-DTYTA 464 Query: 438 STAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 K + PE + KSDV++F Sbjct: 465 HAGAKFPIKWTAPEGLAFNTFSSKSDVWAF 494
>FGFR4_MOUSE (Q03142) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) Length = 799 Score = 72.0 bits (175), Expect = 9e-13 Identities = 48/183 (26%), Positives = 91/183 (49%), Gaps = 15/183 (8%) Frame = +3 Query: 24 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEK 200 Q ST + S + L + +E+E++ + RH+++++L+G C ++ + ++ E K Sbjct: 493 QTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAK 552 Query: 201 GTLKSHLYGSDMP--------------PLSWKKRVEICIGAARGLHYLHTGFAKSIIHRD 338 G L+ L P PLS+ V ARG+ YL + + IHRD Sbjct: 553 GNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLES---RKCIHRD 609 Query: 339 VKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDV 518 + + N+L+ E+ + K++DFGL++ +D ++ + ++ PE + T +SDV Sbjct: 610 LAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDV 669 Query: 519 YSF 527 +SF Sbjct: 670 WSF 672
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 72.0 bits (175), Expect = 9e-13 Identities = 58/177 (32%), Positives = 86/177 (48%), Gaps = 14/177 (7%) Frame = +3 Query: 39 VAVKRGNQKSHQGLRE-FRTEIELLSGLRHRHLVSLIGYCDEQNE--MILVYEYMEKGTL 209 VAVK + LR ++ EIE+L L H H+V G C++Q E + LV EY+ G+L Sbjct: 920 VAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSL 979 Query: 210 KSHLYGSDMPPLSWKKRVEICIGAAR----------GLHYLHTGFAKSIIHRDVKSANIL 359 + +L C+G A+ G+ YLH A+ IHRD+ + N+L Sbjct: 980 RDYL-------------PRHCVGLAQLLLFAQQICEGMAYLH---AQHYIHRDLAARNVL 1023 Query: 360 LDENLMAKVSDFGLSKTGPELDQTH-VSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 LD + + K+ DFGL+K PE + + V + PE + K SDV+SF Sbjct: 1024 LDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSF 1080 Score = 44.7 bits (104), Expect = 2e-04 Identities = 40/132 (30%), Positives = 60/132 (45%), Gaps = 8/132 (6%) Frame = +3 Query: 36 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 215 +V +K + H F L+S + H HL L G C +E I+V E++E G L Sbjct: 631 RVVLKVLDPSHHDIALAFYEXASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDV 690 Query: 216 HLYGS-DMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL-------DEN 371 L P++WK V + +A L YL K+++H +V NILL N Sbjct: 691 WLRRQRGQVPMTWKMVVAQQLASA--LSYLED---KNLVHGNVCGRNILLARLGLEEGTN 745 Query: 372 LMAKVSDFGLSK 407 K+SD G+ + Sbjct: 746 PFIKLSDPGVGQ 757
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 72.0 bits (175), Expect = 9e-13 Identities = 45/148 (30%), Positives = 75/148 (50%) Frame = +3 Query: 84 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRV 263 EF E +++ L H LV L G C +Q + ++ EYM G L ++L ++ + Sbjct: 440 EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYL-REMRHRFQTQQLL 498 Query: 264 EICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 443 E+C + YL +K +HRD+ + N L+++ + KVSDFGLS+ + D+ S Sbjct: 499 EMCKDVCEAMEYLE---SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLD-DEYTSSV 554 Query: 444 AVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 K + PE K + KSD+++F Sbjct: 555 GSKFPVRWSPPEVLMYSKFSSKSDIWAF 582
>BTK_HUMAN (Q06187) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 658 Score = 72.0 bits (175), Expect = 9e-13 Identities = 45/148 (30%), Positives = 75/148 (50%) Frame = +3 Query: 84 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRV 263 EF E +++ L H LV L G C +Q + ++ EYM G L ++L ++ + Sbjct: 440 EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYL-REMRHRFQTQQLL 498 Query: 264 EICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 443 E+C + YL +K +HRD+ + N L+++ + KVSDFGLS+ + D+ S Sbjct: 499 EMCKDVCEAMEYLE---SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLD-DEYTSSV 554 Query: 444 AVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 K + PE K + KSD+++F Sbjct: 555 GSKFPVRWSPPEVLMYSKFSSKSDIWAF 582
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 72.0 bits (175), Expect = 9e-13 Identities = 40/109 (36%), Positives = 63/109 (57%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 + F TE++++ L H +++ IG + ++ L+ EY+E GTLK L D P W+++ Sbjct: 371 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNVD--PFPWQQK 428 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 407 V G A G+ YLH + IIHRD+ S N L+ + V+DFGLS+ Sbjct: 429 VRFAKGIASGMAYLH---SMCIIHRDLNSHNCLIKLDKTVVVADFGLSR 474
>PTK7_HUMAN (Q13308) Tyrosine-protein kinase-like 7 precursor (Colon carcinoma| kinase 4) (CCK-4) Length = 1070 Score = 72.0 bits (175), Expect = 9e-13 Identities = 52/171 (30%), Positives = 78/171 (45%), Gaps = 7/171 (4%) Frame = +3 Query: 33 TKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 212 T V VK K Q +FR E+E+ L H ++V L+G C E +V EY++ LK Sbjct: 825 TLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLEDLK 884 Query: 213 SHLYGS-------DMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDEN 371 L S PLS K++V +C A G+ +L +H+D+ + N L+ Sbjct: 885 QFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSN---NRFVHKDLAARNCLVSAQ 941 Query: 372 LMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 KVS GLSK + H A + ++ PE + KSDV++ Sbjct: 942 RQVKVSALGLSKDVYNSEYYHFRQAWV-ALRWMSPEAILEGDFSTKSDVWA 991
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 72.0 bits (175), Expect = 9e-13 Identities = 51/178 (28%), Positives = 89/178 (50%), Gaps = 4/178 (2%) Frame = +3 Query: 3 KVYKA---VLQDSTKVAVKRGNQKSHQG-LREFRTEIELLSGLRHRHLVSLIGYCDEQNE 170 KVYKA +L + + R + + +++F+ E + + L H ++V + E + Sbjct: 23 KVYKAKCHLLNRIVAIKILRPEFAADENFVKKFKRESQAAASLSHPNIVGIYDVGQEGDI 82 Query: 171 MILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 +V EY++ TLK L + PL K+ VEI R L + H IIHRD+K Sbjct: 83 YYIVMEYVKGRTLKE-LIRENGGPLEVKRAVEIASQVCRALDHAHKN---KIIHRDIKPQ 138 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 NIL+ + + KV+DFG+++ T+ + G+ Y PE + + +++D+YS Sbjct: 139 NILVTDEDVVKVTDFGIARAANGATITYTGDVI-GTAYYFSPEQAKGSIVDERTDIYS 195
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 71.6 bits (174), Expect = 1e-12 Identities = 47/150 (31%), Positives = 77/150 (51%), Gaps = 1/150 (0%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 R+F E ++ H +++ L G + +++V EYME G+L S L D + + Sbjct: 665 RDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQ-FTVIQL 723 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKT-GPELDQTHV 437 V + G A G+ YL +HRD+ + NIL++ NL+ KVSDFGLS+ + + + Sbjct: 724 VGMLRGIASGMKYLSD---MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYT 780 Query: 438 STAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + K + PE +K T SDV+S+ Sbjct: 781 TRGGKIPIRWTSPEAIAYRKFTSASDVWSY 810
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 71.6 bits (174), Expect = 1e-12 Identities = 47/148 (31%), Positives = 74/148 (50%) Frame = +3 Query: 84 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRV 263 EF E +++ L H LV L G C +Q + ++ EYM G L + L + + + Sbjct: 439 EFIDEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNFLRETQR-RFQPAELL 497 Query: 264 EICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 443 E+C + YL +K +HRD+ + N L+++ + KVSDFGLS+ + D+ S Sbjct: 498 EMCKDVCEAMEYLE---SKQFLHRDLAARNCLVNDQGIVKVSDFGLSRYVLD-DEYTSSM 553 Query: 444 AVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 K + PE K + KSDV+SF Sbjct: 554 GSKFPVRWSPPEVLLYSKFSSKSDVWSF 581
>FGFR3_HUMAN (P22607) Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1)| (FGFR-3) (CD333 antigen) Length = 806 Score = 71.6 bits (174), Expect = 1e-12 Identities = 50/179 (27%), Positives = 95/179 (53%), Gaps = 16/179 (8%) Frame = +3 Query: 39 VAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 212 VAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY KG L+ Sbjct: 505 VAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLR 564 Query: 213 SHL-----------YGSDMPP---LSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSA 350 L + + PP L++K V ARG+ YL + + IHRD+ + Sbjct: 565 EFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLAS---QKCIHRDLAAR 621 Query: 351 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 N+L+ E+ + K++DFGL++ LD +T + ++ PE + T +SDV+SF Sbjct: 622 NVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 680
>FGFR4_HUMAN (P22455) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) (CD334 antigen) Length = 802 Score = 71.6 bits (174), Expect = 1e-12 Identities = 49/182 (26%), Positives = 94/182 (51%), Gaps = 16/182 (8%) Frame = +3 Query: 30 STKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKG 203 ++ VAVK + S + L + +E+E++ + RH+++++L+G C ++ + ++ E KG Sbjct: 497 ASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKG 556 Query: 204 TLKSHLYGSDMP--------------PLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDV 341 L+ L P PLS+ V ARG+ YL + + IHRD+ Sbjct: 557 NLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLES---RKCIHRDL 613 Query: 342 KSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVY 521 + N+L+ E+ + K++DFGL++ +D ++ + ++ PE + T +SDV+ Sbjct: 614 AARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVW 673 Query: 522 SF 527 SF Sbjct: 674 SF 675
>SEA_AVIET (P23049) Tyrosine-protein kinase transforming protein SEA (EC| 2.7.10.2) Length = 370 Score = 71.6 bits (174), Expect = 1e-12 Identities = 49/153 (32%), Positives = 78/153 (50%), Gaps = 3/153 (1%) Frame = +3 Query: 78 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEM-ILVYEYMEKGTLKSHLYGSDMPPLSWK 254 + EF E L+ G H ++SL+G C ++ + ++V YM G L+ + + P + K Sbjct: 103 VEEFLREGILMKGFHHPQVLSLLGVCLPRHGLPLVVLPYMRHGDLRHFVRAQERSP-TVK 161 Query: 255 KRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKT--GPELDQ 428 + + + A G+ YL K +HRD+ + N +LDE L KV+DFGL++ G E Sbjct: 162 ELIGFGLQVALGMEYLAQ---KKFVHRDLAARNCMLDETLTVKVADFGLARDVFGKEYYS 218 Query: 429 THVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 K ++ E + QK T KSDV+SF Sbjct: 219 IRQHRHAKLPVRWMALESLQTQKFTTKSDVWSF 251
>ROR1_MOUSE (Q9Z139) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1) Length = 937 Score = 71.2 bits (173), Expect = 2e-12 Identities = 54/196 (27%), Positives = 89/196 (45%), Gaps = 21/196 (10%) Frame = +3 Query: 3 KVYKAVL-----QDSTKVAVKR-GNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQ 164 K+YK L + VA+K + + Q EF+ E L++ L H ++V L+G ++ Sbjct: 486 KIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQE 545 Query: 165 NEMILVYEYMEKGTLKSHLY---------------GSDMPPLSWKKRVEICIGAARGLHY 299 + +++EYM +G L L G+ L + I I A G+ Y Sbjct: 546 QPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEY 605 Query: 300 LHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 479 L + F +H+D+ + NIL+ E L K+SD GLS+ D V + ++ PE Sbjct: 606 LSSHF---FVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSSLPIRWMPPE 662 Query: 480 YYRRQKLTDKSDVYSF 527 K + SD++SF Sbjct: 663 AIMYGKFSSDSDIWSF 678
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 71.2 bits (173), Expect = 2e-12 Identities = 51/164 (31%), Positives = 81/164 (49%), Gaps = 1/164 (0%) Frame = +3 Query: 39 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 218 VA+K N+ S +F E +++ L H LV L G C +Q + +V E+ME G L + Sbjct: 296 VAIKAINEGS-MSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDY 354 Query: 219 LYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 398 L L + +C G+ YL IHRD+ + N L+ + K+SDFG Sbjct: 355 L-RERKGQLQKALLLSMCQDICEGMAYLE---RSCYIHRDLAARNCLVSSACVVKISDFG 410 Query: 399 LSKTGPELDQTHVSTA-VKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +++ LD ++S++ K + PE + K + KSDV+SF Sbjct: 411 MARY--VLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSF 452
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 71.2 bits (173), Expect = 2e-12 Identities = 53/175 (30%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +TKVA+K + F E +++ LRH LV L E+ + +V Sbjct: 290 EVWMGTWNGTTKVAIKT-LKPGTMSPEAFLEEAQIMKKLRHDKLVPLYAVVSEE-PIYIV 347 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E+M KG+L L D L + V++ A G+ ++ + IHRD+++ANIL+ Sbjct: 348 TEFMGKGSLLDFLKEGDGKHLKLPQLVDMASQIADGMAFIER---MNYIHRDLRAANILV 404 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +NL+ K++DFGL++ + + T K + PE + T KSDV+SF Sbjct: 405 ADNLVCKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 458
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 70.9 bits (172), Expect = 2e-12 Identities = 52/175 (29%), Positives = 85/175 (48%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V++ +TKVA+K + F E +++ L+H LV L + + +V Sbjct: 280 EVWRGTWNGNTKVAIKT-LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSRR-PIYIV 337 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L + L V++ A G+ Y+ + IHRD++SANIL+ Sbjct: 338 TEYMSKGSLLIFLKDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSANILV 394 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 L+ K++DFGL++ + + T K + PE + T KSDV+SF Sbjct: 395 GNGLICKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 448
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 70.9 bits (172), Expect = 2e-12 Identities = 47/150 (31%), Positives = 77/150 (51%), Gaps = 1/150 (0%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 R+F E ++ H +++ L G + +++V EYME G+L S L D + + Sbjct: 666 RDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQ-FTVIQL 724 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKT-GPELDQTHV 437 V + G A G+ YL +HRD+ + NIL++ NL+ KVSDFGLS+ + + + Sbjct: 725 VGMLRGIASGMKYLSD---MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYT 781 Query: 438 STAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + K + PE +K T SDV+S+ Sbjct: 782 TRGGKIPVRWTSPEATAYRKFTSASDVWSY 811
>INSR_RAT (P15127) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1383 Score = 70.9 bits (172), Expect = 2e-12 Identities = 49/174 (28%), Positives = 82/174 (47%), Gaps = 9/174 (5%) Frame = +3 Query: 33 TKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 209 T+VAVK N+ + R EF E ++ G H+V L+G + ++V E M G L Sbjct: 1053 TRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDL 1112 Query: 210 KSHL--------YGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 KSHL PP + ++ +++ A G+ YL+ AK +HRD+ + N ++ Sbjct: 1113 KSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLN---AKKFVHRDLAARNCMVA 1169 Query: 366 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + K+ DFG+++ E D ++ PE + T SD++SF Sbjct: 1170 HDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSF 1223
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 70.9 bits (172), Expect = 2e-12 Identities = 48/150 (32%), Positives = 77/150 (51%), Gaps = 1/150 (0%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 R+F E ++ H ++V L G +++V EYME G L + L D + + Sbjct: 672 RDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEYMENGALDAFLRKHD-GQFTVIQL 730 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKT-GPELDQTHV 437 V + G A G+ YL +HRD+ + NIL++ NL+ KVSDFGLS+ + + + Sbjct: 731 VGMLRGIAAGMRYLAD---MGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYT 787 Query: 438 STAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +T K + PE + +K T SDV+S+ Sbjct: 788 TTGGKIPVRWTAPEAIQYRKFTSASDVWSY 817
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 70.9 bits (172), Expect = 2e-12 Identities = 46/150 (30%), Positives = 79/150 (52%), Gaps = 1/150 (0%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 R+F +E ++ H +++ L G + +++V EYME G+L + L +D + + Sbjct: 721 RDFLSEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKND-GQFTVIQL 779 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKT-GPELDQTHV 437 V + G A G+ YL +HRD+ + NIL++ NL+ KVSDFGLS+ + + + Sbjct: 780 VGMLRGIAAGMKYLSD---MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYT 836 Query: 438 STAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + K + PE +K T SDV+S+ Sbjct: 837 TRGGKIPIRWTAPEAIAFRKFTSASDVWSY 866
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 70.9 bits (172), Expect = 2e-12 Identities = 51/175 (29%), Positives = 89/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ V +T VAVK + + +++F E +++ + H +L+ L C + +V Sbjct: 79 EVWAGVWNGTTAVAVKTLKPDTME-VKDFVQEAQVMKKIHHPNLLQLYAVCTIGEPIYIV 137 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E M+ G++ +L + ++ + V++ A G+ YL A S IHRD+ + NIL+ Sbjct: 138 TELMKYGSMLEYLKHGEGKNITLHQMVDMSAQIASGMTYLE---AHSYIHRDLAARNILV 194 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 E + KV+DFGL++ E D + K + PE + T KSDV+SF Sbjct: 195 GEGNVCKVADFGLARVIKE-DIYNPREGTKFPIKWTAPEAALYNRFTIKSDVWSF 248
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 70.9 bits (172), Expect = 2e-12 Identities = 47/148 (31%), Positives = 75/148 (50%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 ++FR E+E+ S LRH +++ L G+ +++ + L+ EY+ G L L + + Sbjct: 142 KQFRREVEIQSNLRHTNVLRLFGHFHDKDRVYLILEYVVHGELYKLL--RNQKRFTESTA 199 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVS 440 + L YLH K+IIHRD+K NILL N K+SDFG S P ++ Sbjct: 200 SSYIYQMSEALLYLH---GKNIIHRDIKPENILLHFNDTIKISDFGWSVHAP----SNRR 252 Query: 441 TAVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + + G+ YL PE + + DV+S Sbjct: 253 STLCGTMDYLPPEIVQSRPYDKNVDVWS 280
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 70.9 bits (172), Expect = 2e-12 Identities = 52/175 (29%), Positives = 84/175 (48%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ A TKVAVK S + F E L+ L+H LV L Q + +V Sbjct: 272 EVWMATYNKHTKVAVKTMKPGS-MSVEAFLAEANLMKSLQHDKLVKLHAVVS-QEPIFIV 329 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E+M KG+L L + K ++ + G+ ++ ++ IHRD+++ANIL+ Sbjct: 330 TEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQ---RNYIHRDLRAANILV 386 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +L+ K++DFGL++ + + T K + PE T KSDV+SF Sbjct: 387 SASLVCKIADFGLARIIEDNEYT-AREGAKFPIKWTAPEAINFGSFTIKSDVWSF 440
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 70.9 bits (172), Expect = 2e-12 Identities = 54/175 (30%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +TKVA+K + F E +++ LRH LV L E+ + +V Sbjct: 283 EVWIGTWNGTTKVAIKTLKPGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIV 340 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYM KG+L L + L + V++ A G+ Y+ + IHRD+++ANIL+ Sbjct: 341 TEYMIKGSLLDFLKEGNGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILV 397 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +NL+ K++DFGL++ + + T K + PE + T KSDV+SF Sbjct: 398 GDNLVCKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 451
>MOS_XENLA (P12965) Serine/threonine-protein kinase mos (EC 2.7.11.1)| (pp39-mos) Length = 359 Score = 70.9 bits (172), Expect = 2e-12 Identities = 59/192 (30%), Positives = 89/192 (46%), Gaps = 18/192 (9%) Frame = +3 Query: 6 VYKAVLQDSTKVA--VKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYC-----DEQ 164 VY+A + T VKR + S + F E+ + LRH H+V ++ D Sbjct: 77 VYRATYRGETVALKKVKRSTKNSLASRQSFWAELNA-ARLRHPHVVRVVAASASCPGDPG 135 Query: 165 NEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAAR----GLHYLHTGFAKSIIH 332 ++ EY GTL +YG PPL EIC+ AR GL +LH ++H Sbjct: 136 CPGTIIMEYTGTGTLHQRIYGRS-PPLG----AEICMRYARHVADGLRFLHRD---GVVH 187 Query: 333 RDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTA-------VKGSFGYLDPEYYRR 491 D+K AN+LL + K+ DFG S+ E D+ V G++ + PE + Sbjct: 188 LDLKPANVLLAPGDLCKIGDFGCSQRLREGDEAAGGEPCCTQLRHVGGTYTHRAPELLKG 247 Query: 492 QKLTDKSDVYSF 527 + +T K+D+YSF Sbjct: 248 EPVTAKADIYSF 259
>LIMK2_MOUSE (O54785) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 70.9 bits (172), Expect = 2e-12 Identities = 39/109 (35%), Positives = 63/109 (57%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 + F TE++++ L H +++ IG + ++ L+ EY+E GTLK L D P W+++ Sbjct: 371 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSVD--PFPWQQK 428 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 407 V G + G+ YLH + IIHRD+ S N L+ + V+DFGLS+ Sbjct: 429 VRFAKGISSGMAYLH---SMCIIHRDLNSHNCLIKLDKTVVVADFGLSR 474
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 70.9 bits (172), Expect = 2e-12 Identities = 58/177 (32%), Positives = 91/177 (51%), Gaps = 5/177 (2%) Frame = +3 Query: 12 KAVLQDSTKVAVK--RGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVY 185 KA + + VA+K +G Q REF +E ++ H +++ L G ++++ Sbjct: 635 KAPGKKESCVAIKTLKGGYTERQR-REFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILT 693 Query: 186 EYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILLD 365 E+ME G L S L +D + + V + G A G+ YL S +HRD+ + NIL++ Sbjct: 694 EFMENGALDSFLRLND-GQFTVIQLVGMLRGIASGMRYLAE---MSYVHRDLAARNILVN 749 Query: 366 ENLMAKVSDFGLSKTGPE--LDQTHVST-AVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 NL+ KVSDFGLS+ E D T+ S+ K S + PE +K T SD +S+ Sbjct: 750 SNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKISIRWTAPEAIAFRKFTSASDAWSY 806
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 70.9 bits (172), Expect = 2e-12 Identities = 53/175 (30%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +TKVA+K + F E +++ LRH LV L E+ + +V Sbjct: 287 EVWMGTWNGTTKVAIKTLKPGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIV 344 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E+M KG+L L + L + V++ A G+ Y+ + IHRD+++ANIL+ Sbjct: 345 TEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILV 401 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +NL+ K++DFGL++ + + T K + PE + T KSDV+SF Sbjct: 402 GDNLVCKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 455
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 70.5 bits (171), Expect = 3e-12 Identities = 47/150 (31%), Positives = 76/150 (50%), Gaps = 1/150 (0%) Frame = +3 Query: 81 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 R+F E ++ H +++ L G + ++V EYME G+L S L D + + Sbjct: 665 RDFLGEASIMGQFDHPNIIRLEGVVTKSKPEMIVTEYMENGSLDSFLRKHDAQ-FTVIQL 723 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKT-GPELDQTHV 437 V + G A G+ YL +HRD+ + NIL++ NL+ KVSDFGLS+ + + + Sbjct: 724 VGMLRGIASGMKYLSD---MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYT 780 Query: 438 STAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + K + PE +K T SDV+S+ Sbjct: 781 TRGGKIPIRWTSPEAMSYRKFTSASDVWSY 810
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 70.5 bits (171), Expect = 3e-12 Identities = 54/175 (30%), Positives = 84/175 (48%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ TKVAVK Q S F E L+ L+H LV L Q + ++ Sbjct: 257 EVWMGYYNGHTKVAVKSLKQGS-MSPDAFLAEANLMKQLQHPRLVRLYAVVT-QEPIYII 314 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 EYME G+L L L+ K +++ A G+ ++ ++ IHRD+++ANIL+ Sbjct: 315 TEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEE---QNYIHRDLRAANILV 371 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + L K++DFGL++ + + T K + PE T KSDV+SF Sbjct: 372 SDTLSCKIADFGLARLIEDNEYT-AREGAKFPIKWTAPEAINYGTFTIKSDVWSF 425
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 70.5 bits (171), Expect = 3e-12 Identities = 53/178 (29%), Positives = 88/178 (49%), Gaps = 3/178 (1%) Frame = +3 Query: 3 KVYKAVLQD-STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 +VY+ V + S VAVK + + + + EF E ++ ++H +LV L+G C + + Sbjct: 141 EVYEGVWKKYSLTVAVKTLKEDTME-VEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYI 199 Query: 180 VYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 + E+M G L +L + +S + + + + YL K+ IHRD+ + N L Sbjct: 200 ITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEK---KNFIHRDLAARNCL 256 Query: 360 LDENLMAKVSDFGLSK--TGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + EN + KV+DFGLS+ TG D K + PE K + KSDV++F Sbjct: 257 VGENHLVKVADFGLSRLMTG---DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAF 311
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 70.5 bits (171), Expect = 3e-12 Identities = 45/147 (30%), Positives = 71/147 (48%) Frame = +3 Query: 84 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRV 263 + R E+E+ S LRH +++ L GY + + L+ EY GT+ L + ++ Sbjct: 168 QLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYREL--QKLSKFDEQRTA 225 Query: 264 EICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 443 A L Y H+ K +IHRD+K N+LL N K++DFG S P + T Sbjct: 226 TYITELANALSYCHS---KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRR----T 278 Query: 444 AVKGSFGYLDPEYYRRQKLTDKSDVYS 524 + G+ YL PE + +K D++S Sbjct: 279 TMCGTLDYLPPEMIEGRMHDEKVDLWS 305
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 70.5 bits (171), Expect = 3e-12 Identities = 47/150 (31%), Positives = 77/150 (51%), Gaps = 3/150 (2%) Frame = +3 Query: 87 FRTEIELLSGLRHRHLVSLIGYCDEQNE--MILVYEYMEKGTLKSHLYGSDMPPLSWKKR 260 ++ EI++L L H H++ G C++Q E + LV EY+ G+L+ +L + + Sbjct: 944 WKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL---PRHSIGLAQL 1000 Query: 261 VEICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTH-V 437 + G+ YLH A+ IHRD+ + N+LLD + + K+ DFGL+K PE + + V Sbjct: 1001 LLFAQQICEGMAYLH---AQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRV 1057 Query: 438 STAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + PE + K SDV+SF Sbjct: 1058 REDGDSPVFWYAPECLKEYKFYYASDVWSF 1087 Score = 42.7 bits (99), Expect = 6e-04 Identities = 35/110 (31%), Positives = 51/110 (46%), Gaps = 1/110 (0%) Frame = +3 Query: 36 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 215 +V +K + H F L+S + H HL + G C E I+V EY+E G L Sbjct: 638 RVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDV 697 Query: 216 HLYGS-DMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 L P++WK V + +A L YL K+++H +V NILL Sbjct: 698 WLRRERGHVPMAWKMVVAQQLASA--LSYLEN---KNLVHGNVCGRNILL 742
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 70.5 bits (171), Expect = 3e-12 Identities = 45/148 (30%), Positives = 84/148 (56%), Gaps = 3/148 (2%) Frame = +3 Query: 90 RTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS--HLYGSDMPPLSWKKRV 263 R+E+ L L H ++V +G+ ++ N L EY+ G++ S +YG PL Sbjct: 1226 RSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTT 1285 Query: 264 EICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 443 ++ +GL YLH+ K I+HRD+K+ N+LLD++ + K+SDFG+S+ ++ ++ Sbjct: 1286 QVL----KGLAYLHS---KGILHRDMKADNLLLDQDGICKISDFGISRKSKDI-YSNSDM 1337 Query: 444 AVKGSFGYLDPEYY-RRQKLTDKSDVYS 524 ++G+ ++ PE +Q + K D++S Sbjct: 1338 TMRGTVFWMAPEMVDTKQGYSAKVDIWS 1365
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 70.5 bits (171), Expect = 3e-12 Identities = 53/175 (30%), Positives = 88/175 (50%) Frame = +3 Query: 3 KVYKAVLQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILV 182 +V+ +TKVA+K + F E +++ LRH LV L E+ + +V Sbjct: 280 EVWMGTWNGTTKVAIKTLKLGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIV 337 Query: 183 YEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANILL 362 E+M KG+L L + L + V++ A G+ Y+ + IHRD+++ANIL+ Sbjct: 338 TEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILV 394 Query: 363 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 +NL+ K++DFGL++ + + T K + PE + T KSDV+SF Sbjct: 395 GDNLVCKIADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 448
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 70.5 bits (171), Expect = 3e-12 Identities = 53/178 (29%), Positives = 88/178 (49%), Gaps = 3/178 (1%) Frame = +3 Query: 3 KVYKAVLQD-STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMIL 179 +VY+ V + S VAVK + + + + EF E ++ ++H +LV L+G C + + Sbjct: 255 EVYEGVWKKYSLTVAVKTLKEDTME-VEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYI 313 Query: 180 VYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLHYLHTGFAKSIIHRDVKSANIL 359 + E+M G L +L + +S + + + + YL K+ IHRD+ + N L Sbjct: 314 ITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEK---KNFIHRDLAARNCL 370 Query: 360 LDENLMAKVSDFGLSK--TGPELDQTHVSTAVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 + EN + KV+DFGLS+ TG D K + PE K + KSDV++F Sbjct: 371 VGENHLVKVADFGLSRLMTG---DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAF 425
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 70.1 bits (170), Expect = 4e-12 Identities = 48/149 (32%), Positives = 77/149 (51%), Gaps = 1/149 (0%) Frame = +3 Query: 84 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRV 263 EF E + + L H LV G C ++ + +V EY+ G L ++L S L + + Sbjct: 432 EFFQEAQTMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLK-SHGKGLESCQLL 490 Query: 264 EICIGAARGLHYLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 443 E+C G+ +L + IHRD+ + N L+D +L KVSDFG+++ LD +VS+ Sbjct: 491 EMCYDVCEGMAFLES---HQFIHRDLAARNCLVDSDLSVKVSDFGMTRY--VLDDQYVSS 545 Query: 444 -AVKGSFGYLDPEYYRRQKLTDKSDVYSF 527 K + PE + K + KSDV++F Sbjct: 546 VGTKFPVKWSAPEVFHYFKYSSKSDVWAF 574
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 70.1 bits (170), Expect = 4e-12 Identities = 44/141 (31%), Positives = 75/141 (53%), Gaps = 4/141 (2%) Frame = +3 Query: 117 LRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLSWKKRVEICIGAARGLH 296 ++ +H+VS+ G C + + +V E+M G+L+ L L W ++ I + ++ Sbjct: 90 IKFQHIVSIYGVCKQP--LGIVMEFMASGSLEKTL---PTHSLCWPLKLRIIHETSLAMN 144 Query: 297 YLHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV--STAVKGSFGYL 470 +LH+ ++H D+K NILLD N+ K+SDFGLSK + Q +A++G+ Y+ Sbjct: 145 FLHS-IKPPLLHLDLKPGNILLDNNMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYI 203 Query: 471 DPEYYRRQKLT--DKSDVYSF 527 PE + + DVYSF Sbjct: 204 PPEMFLENNKAPGPEYDVYSF 224 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 75,895,995 Number of Sequences: 219361 Number of extensions: 1572096 Number of successful extensions: 7161 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6077 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6346 length of database: 80,573,946 effective HSP length: 105 effective length of database: 57,541,041 effective search space used: 4027872870 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
