ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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更新日：2016年5月1日

Clone Information

BLAST Search Result

Clone Name basd27i21
Clone Library Name barley_pub
No. Definition Score
(bits)		 E
Value
1BIOF_BACSH (P22806) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 84 2e-16
2KBL_BACSU (O31777) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 74 2e-13
3BIOF_BACSU (P53556) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 72 6e-13
4BIOF_MYCLE (P45487) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 70 2e-12
5HEM1_BRAJA (P08262) 5-aminolevulinate synthase (EC 2.3.1.37) (5-... 66 4e-11
6BIOF_MYCTU (P0A4X4) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 65 1e-10
7BIOF_MYCBO (P0A4X5) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 65 1e-10
8BIOF_HAEIN (P44422) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 63 3e-10
9HEM1_RICPR (Q9ZCB8) 5-aminolevulinate synthase (EC 2.3.1.37) (5-... 62 8e-10
10HEM1_NEUCR (Q7RVY5) 5-aminolevulinate synthase, mitochondrial pr... 60 2e-09
11HEM1_EMENI (P38092) 5-aminolevulinate synthase, mitochondrial pr... 59 5e-09
12HEM0_OPSTA (P43090) 5-aminolevulinate synthase, erythroid-specif... 59 5e-09
13HEM1_YARLI (Q6CCW0) 5-aminolevulinate synthase, mitochondrial pr... 59 7e-09
14KBL_STAAC (Q5HIC5) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 57 3e-08
15HEM1_SCHPO (O14092) 5-aminolevulinate synthase, mitochondrial pr... 57 3e-08
16KBL_SHIFL (P0AB79) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 56 3e-08
17KBL_SALTY (P37419) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 56 3e-08
18KBL_ECOLI (P0AB77) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 56 3e-08
19KBL_ECO57 (P0AB78) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 56 3e-08
20KBL_STAAW (Q8NXY3) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 56 5e-08
21KBL_STAAS (Q6GBT7) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 56 5e-08
22KBL_STAAR (Q6GJB8) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 56 5e-08
23KBL_STAAN (P60120) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 56 5e-08
24KBL_STAAM (P60121) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 56 5e-08
25HEM1_RHOCA (P18079) 5-aminolevulinate synthase (EC 2.3.1.37) (5-... 56 5e-08
26BIOF_AQUAE (O66875) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 55 6e-08
27HEM0_BRARE (Q9YHT4) 5-aminolevulinate synthase, erythroid-specif... 55 6e-08
28HEM1_RHOS4 (Q04512) 5-aminolevulinate synthase 1 (EC 2.3.1.37) (... 54 2e-07
29HEM1_ASHGO (Q75DX7) 5-aminolevulinate synthase, mitochondrial pr... 54 2e-07
30HEM1_DELLE (Q9XS79) 5-aminolevulinate synthase, nonspecific, mit... 54 2e-07
31KBL_OCEIH (Q8EM07) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 53 3e-07
32HEM1_CANGA (Q6FXE3) 5-aminolevulinate synthase, mitochondrial pr... 53 3e-07
33HEM0_CHICK (P18080) 5-aminolevulinate synthase, erythroid-specif... 53 4e-07
34HEM1_PARDE (P43089) 5-aminolevulinate synthase (EC 2.3.1.37) (5-... 52 5e-07
35HEM1_OPSTA (P43091) 5-aminolevulinate synthase, nonspecific, mit... 52 7e-07
36HEM1_AGRRD (P26505) 5-aminolevulinate synthase (EC 2.3.1.37) (5-... 52 7e-07
37HEM1_RAT (P13195) 5-aminolevulinate synthase, nonspecific, mitoc... 52 9e-07
38HEM0_RHOS4 (Q06965) 5-aminolevulinate synthase 2 (EC 2.3.1.37) (... 52 9e-07
39HEM0_DELLE (Q9XT75) 5-aminolevulinate synthase, erythroid-specif... 52 9e-07
40HEM1_HUMAN (P13196) 5-aminolevulinate synthase, nonspecific, mit... 51 1e-06
41KBL_BACCR (Q81I05) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 51 1e-06
42BIOF_ENTAG (Q47829) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 51 1e-06
43HEM1_MOUSE (Q8VC19) 5-aminolevulinate synthase, nonspecific, mit... 51 1e-06
44HEM1_RHIME (P08080) 5-aminolevulinate synthase (EC 2.3.1.37) (5-... 51 1e-06
45HEM1_KLULA (P78698) 5-aminolevulinate synthase, mitochondrial pr... 51 1e-06
46HEM0_HUMAN (P22557) 5-aminolevulinate synthase, erythroid-specif... 51 1e-06
47HEM1_CANAL (O94069) 5-aminolevulinate synthase, mitochondrial pr... 50 2e-06
48KBL_BACAN (Q81V80) 2-amino-3-ketobutyrate coenzyme A ligase (EC ... 50 2e-06
49HEM1_AGABI (Q92403) 5-aminolevulinate synthase, mitochondrial pr... 50 2e-06
50HEM1_YEAST (P09950) 5-aminolevulinate synthase, mitochondrial pr... 50 3e-06
51BIOF_ECOLI (P12998) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 50 3e-06
52BIOF_BUCBP (Q89AK6) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 50 3e-06
53BIOF_SERMA (P36570) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 49 4e-06
54HEM0_RAT (Q63147) 5-aminolevulinate synthase, erythroid-specific... 48 9e-06
55HEM0_MOUSE (P08680) 5-aminolevulinate synthase, erythroid-specif... 48 1e-05
56HEM1_CHICK (P07997) 5-aminolevulinate synthase, nonspecific, mit... 47 2e-05
57BIOF_METJA (Q58694) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 47 2e-05
58KBL_HUMAN (O75600) 2-amino-3-ketobutyrate coenzyme A ligase, mit... 47 2e-05
59KBL_MOUSE (O88986) 2-amino-3-ketobutyrate coenzyme A ligase, mit... 46 5e-05
60HEM1_DEBHA (Q6BX71) 5-aminolevulinate synthase, mitochondrial pr... 44 1e-04
61BIOF_HELPY (O25320) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 40 0.003
62LCB2_HUMAN (O15270) Serine palmitoyltransferase 2 (EC 2.3.1.50) ... 39 0.006
63BIOF_HELPJ (Q9ZLN3) 8-amino-7-oxononanoate synthase (EC 2.3.1.47... 39 0.007
64LCB2_CRIGR (O54694) Serine palmitoyltransferase 2 (EC 2.3.1.50) ... 37 0.022
65LCB2_MOUSE (P97363) Serine palmitoyltransferase 2 (EC 2.3.1.50) ... 36 0.049
66LCB1_YEAST (P25045) Serine palmitoyltransferase 1 (EC 2.3.1.50) ... 35 0.063
67LCB2_YEAST (P40970) Serine palmitoyltransferase 2 (EC 2.3.1.50) ... 35 0.083
68LCB2_KLULA (P48241) Serine palmitoyltransferase 2 (EC 2.3.1.50) ... 34 0.18
69LCB2_SCHPO (Q09925) Serine palmitoyltransferase 2 (EC 2.3.1.50) ... 33 0.24
70NDRG1_MOUSE (Q62433) Protein NDRG1 (N-myc downstream-regulated g... 32 0.54
71NDRG3_XENLA (Q6GQL1) Protein NDRG3 32 0.70
72NDRG3_MOUSE (Q9QYF9) Protein NDRG3 (Protein Ndr3) 31 1.6
73NDRG1_HUMAN (Q92597) Protein NDRG1 (N-myc downstream-regulated g... 30 2.0
74NDRG3_XENTR (Q6DFS4) Protein NDRG3 30 2.7
75NDR1B_XENLA (Q7ZWV3) Protein NDRG1-B (xNDRG1-B) 30 2.7
76NDR1A_XENLA (Q641F2) Protein NDRG1-A (xNDRG1-A) 30 2.7
77LPXD_AGRT5 (Q8UFL5) UDP-3-O-[3-hydroxymyristoyl] glucosamine N-a... 30 3.5
78NDRG3_HUMAN (Q9UGV2) Protein NDRG3 29 5.9
79NDRG1_XENTR (Q66IG4) Protein NDRG1 29 5.9
80AROC_METAC (Q8TT87) Chorismate synthase (EC 4.2.3.5) (5-enolpyru... 29 5.9
81ATP7B_HUMAN (P35670) Copper-transporting ATPase 2 (EC 3.6.3.4) (... 28 7.7
82BCSA_PSEFL (P58931) Cellulose synthase catalytic subunit [UDP-fo... 28 7.7 
>BIOF_BACSH (P22806) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 389

 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 47/144 (32%), Positives = 76/144 (52%), Gaps = 6/144 (4%)
 Frame = +1

Query: 25  TLVCGDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFST 204
           T V G++G G  +    +  ID +VGTLSKA G +GGFV+ S+  K+ + +  RSFIF T
Sbjct: 208 TGVLGNDGCGTADYFGLKDEIDFTVGTLSKAIGAEGGFVSTSSIAKNYLLNNARSFIFQT 267

Query: 205 ALPVPVVASVQAALHVSRKERWRRSLVWRHVQYF------ASLTKLNITSPIISIVVGSE 366
           AL    + + +  + + + E  RR  + ++ QY       +        +PIIS+++G  
Sbjct: 268 ALSPSAIEAAREGISIIQNEPERRKQLLKNAQYLRLKLEESGFVMKEGETPIISLIIGGS 327

Query: 367 EAALRAGRHMLRSGFHVTPIRPPT 438
             A++    +L  G  +  IRPPT
Sbjct: 328 HEAMQFSAKLLDEGVFIPAIRPPT 351
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>KBL_BACSU (O31777) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine C-acetyltransferase)
          Length = 392

 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 48/142 (33%), Positives = 70/142 (49%), Gaps = 6/142 (4%)
 Frame = +1

Query: 31  VCGDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTAL 210
           V G+NG G       +  + I VGTLSKA G  GG+ A S      ++ +GR F+FST+ 
Sbjct: 213 VLGENGRGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSH 272

Query: 211 PVPVVASVQAALHVSRKERWRRSLVWRHVQYF-ASLTKLNIT-----SPIISIVVGSEEA 372
           P  V A+   A+ V  +E      +W +  YF A L K+ +T     +PI+ I++G E  
Sbjct: 273 PPAVTAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGV 332

Query: 373 ALRAGRHMLRSGFHVTPIRPPT 438
           A +    +L  G     I  PT
Sbjct: 333 AKQFSDQLLSRGVFAQSIVFPT 354
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>BIOF_BACSU (P53556) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 389

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 47/146 (32%), Positives = 71/146 (48%), Gaps = 8/146 (5%)
 Frame = +1

Query: 25  TLVCGDNGGGVPELLECESGI--DISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIF 198
           T V GD+G G  E      G+  DI +GTLSKA G +GGF A S  +   + +  R+FIF
Sbjct: 210 TGVLGDSGQGTSEYF----GVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIF 265

Query: 199 STALPVPVVASVQAALHVSRKERWRRSLVWRHVQYF-ASLTKLNIT-----SPIISIVVG 360
            TA+P    A+   A ++    R +R L++ ++     SL  +        +PII +V+G
Sbjct: 266 QTAIPPASCAAAHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIG 325

Query: 361 SEEAALRAGRHMLRSGFHVTPIRPPT 438
                +     +   G +   IRPPT
Sbjct: 326 DAHKTVLFAEKLQGKGIYAPAIRPPT 351
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>BIOF_MYCLE (P45487) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 385

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 42/114 (36%), Positives = 61/114 (53%), Gaps = 2/114 (1%)
 Frame = +1

Query: 103 TLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVVASVQAALHVSRKERWRRSL 282
           T+SKA G QGG V  S+  ++ + +  R FIF T L    V + +AAL + + E WR   
Sbjct: 232 TMSKALGSQGGAVLGSSAVRAHLINTARPFIFDTGLAPAAVGAARAALQILKAETWRPEA 291

Query: 283 VWRHVQYFASLTKLN--ITSPIISIVVGSEEAALRAGRHMLRSGFHVTPIRPPT 438
           V +H +  A +  L+    S ++S+V+G  E AL A    L +G  V   RPPT
Sbjct: 292 VLQHARTLAKICDLSELPQSAVVSVVLGDPEVALAAAIACLDAGVRVGCFRPPT 345
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>HEM1_BRAJA (P08262) 5-aminolevulinate synthase (EC 2.3.1.37) (5-aminolevulinic|
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase)
          Length = 409

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 44/144 (30%), Positives = 69/144 (47%), Gaps = 10/144 (6%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  GGG+ E       IDI  GTL+KA GC GG++A + +    ++S    FIF+TALP 
Sbjct: 222 GPRGGGIAERDGVMHRIDILEGTLAKAFGCLGGYIAANGQIIDAVRSYAPGFIFTTALPP 281

Query: 217 PVVASVQAALHVSRKERWRRSLVWRH---------VQYFASLTKLNITSPIISIVVGSEE 369
            + ++  AA+   +   W R    RH         +   A L  ++  + I+ + +G  E
Sbjct: 282 AICSAATAAIKHLKTSSWERE---RHQDRAARVKAILNAAGLPVMSSDTHIVPLFIGDAE 338

Query: 370 AALRAGRHMLRS-GFHVTPIRPPT 438
              +A   +L   G ++ PI  PT
Sbjct: 339 KCKQASDLLLEEHGIYIQPINYPT 362
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>BIOF_MYCTU (P0A4X4) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 386

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 41/114 (35%), Positives = 57/114 (50%), Gaps = 2/114 (1%)
 Frame = +1

Query: 103 TLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVVASVQAALHVSRKERWRRSL 282
           TLSKA G QGG V   T  ++ +    R FIF T L    V + +AAL V + E WR   
Sbjct: 236 TLSKALGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQA 295

Query: 283 VWRHVQYFASLTKLNIT--SPIISIVVGSEEAALRAGRHMLRSGFHVTPIRPPT 438
           V  H    A +  +     S ++S+++G  E+A+ A    L +G  V   RPPT
Sbjct: 296 VLNHAGELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGVKVGCFRPPT 349
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>BIOF_MYCBO (P0A4X5) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 386

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 41/114 (35%), Positives = 57/114 (50%), Gaps = 2/114 (1%)
 Frame = +1

Query: 103 TLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVVASVQAALHVSRKERWRRSL 282
           TLSKA G QGG V   T  ++ +    R FIF T L    V + +AAL V + E WR   
Sbjct: 236 TLSKALGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQA 295

Query: 283 VWRHVQYFASLTKLNIT--SPIISIVVGSEEAALRAGRHMLRSGFHVTPIRPPT 438
           V  H    A +  +     S ++S+++G  E+A+ A    L +G  V   RPPT
Sbjct: 296 VLNHAGELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGVKVGCFRPPT 349
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>BIOF_HAEIN (P44422) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 380

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 45/147 (30%), Positives = 63/147 (42%), Gaps = 11/147 (7%)
 Frame = +1

Query: 31  VCGDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTAL 210
           V G NG G+ E     + ID+ VGT  KA    G +V C    K  + ++ R  IFSTAL
Sbjct: 212 VYGQNGLGIAERANVIADIDLLVGTFGKALASMGAYVVCDQILKECLINQMRPLIFSTAL 271

Query: 211 PVPVVASV-----------QAALHVSRKERWRRSLVWRHVQYFASLTKLNITSPIISIVV 357
           P   VA             +   H+ +   + R  V    Q   S T       I+  ++
Sbjct: 272 PPFNVAWTHFIFERLPQLSKERTHLEQLSAFLRQEVEHRTQIMPSQT------CIVPYIL 325

Query: 358 GSEEAALRAGRHMLRSGFHVTPIRPPT 438
           G  EA L   + +   G++  PIRPPT
Sbjct: 326 GENEATLAKAKDLQEQGYYCLPIRPPT 352
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>HEM1_RICPR (Q9ZCB8) 5-aminolevulinate synthase (EC 2.3.1.37) (5-aminolevulinic|
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase)
          Length = 414

 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 47/144 (32%), Positives = 68/144 (47%), Gaps = 10/144 (6%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  GGG+ ELL+C + IDI  GTL+KA G  GG++  +      I+     FIF+T+LP 
Sbjct: 219 GKQGGGISELLDCSNQIDIIQGTLAKAYGTIGGYITSNYNLIDAIRLTAPGFIFTTSLP- 277

Query: 217 PVVASVQAALHVSRKERWRRSLVWRHVQYFASLTK---------LNITSPIISIVVGSEE 369
           PV+++  AA H  R  +       +H +    L           L   S II I++G   
Sbjct: 278 PVIST--AATHSIRHLKESNEERIKHQEVVTKLKNSFEHFNIPYLKNESHIIPIIIGDPI 335

Query: 370 AALRAGRHMLRS-GFHVTPIRPPT 438
            A +    +L   G +V  I  PT
Sbjct: 336 KATKVSNMLLNEYGIYVQHINFPT 359
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>HEM1_NEUCR (Q7RVY5) 5-aminolevulinate synthase, mitochondrial precursor (EC|
           2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
          Length = 544

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 50/153 (32%), Positives = 69/153 (45%), Gaps = 19/153 (12%)
 Frame = +1

Query: 37  GDNGGGVPELLECESG------------IDISVGTLSKAAGCQGGFVACSTRWKSLIQSR 180
           G +G GV E L+ E+             IDI  GTL KA GC GG++A S +    I+S 
Sbjct: 269 GPHGAGVAEHLDWEAHQRGETKGTIADRIDIYSGTLGKAYGCVGGYIAGSAKLVDTIRSL 328

Query: 181 GRSFIFSTALPVPVVASVQAALHVSRKERWRRSLVWRHVQYF------ASLTKLNITSPI 342
              FIF+T LP  V+A  +AA+         R L   H +          +  +   S I
Sbjct: 329 APGFIFTTTLPPAVMAGARAAIEYQMSYDGDRRLQQLHTRAVKEALADRDIPVIPNPSHI 388

Query: 343 ISIVVGSEEAALRAGRHMLRS-GFHVTPIRPPT 438
           I I+VG+ E A +A   +L     +V  I  PT
Sbjct: 389 IPILVGNAELAKKASDKLLNDHQIYVQSINYPT 421
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>HEM1_EMENI (P38092) 5-aminolevulinate synthase, mitochondrial precursor (EC|
           2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
          Length = 648

 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 50/159 (31%), Positives = 69/159 (43%), Gaps = 25/159 (15%)
 Frame = +1

Query: 37  GDNGGGVPELLECE------------------SGIDISVGTLSKAAGCQGGFVACSTRWK 162
           G +G GV E L+ E                    I+I  GTL KA GC GG++A S    
Sbjct: 369 GPHGAGVAEHLDYEIYASQDTANPLSTKGTVMDRINIITGTLGKAYGCVGGYIAGSAALV 428

Query: 163 SLIQSRGRSFIFSTALPVPVVASVQAALHVSRKERWRRSLVWRHV----QYFASLTKLNI 330
             I+S    FIF+T+LP   +A    A+    + +  R L   H     Q F  L    I
Sbjct: 429 DTIRSLAPGFIFTTSLPPATMAGADTAIRYQARHQQDRILQQLHTRAVKQSFKDLDIPVI 488

Query: 331 TSP--IISIVVGSEEAALRAGRHMLRS-GFHVTPIRPPT 438
            +P  I+ ++VG  E A +A   +L   G +V  I  PT
Sbjct: 489 PNPSHIVPLLVGDAELAKQASDKLLEEHGIYVQAINYPT 527
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>HEM0_OPSTA (P43090) 5-aminolevulinate synthase, erythroid-specific,|
           mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase) (ALAS-E)
          Length = 582

 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 48/143 (33%), Positives = 68/143 (47%), Gaps = 9/143 (6%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G +G GV E       IDI  GTL KA GC GG+VA S      ++S    FIF+T+LP 
Sbjct: 361 GAHGAGVGERDNVMHKIDIVSGTLGKAFGCVGGYVASSAALVDTVRSFAAGFIFTTSLPP 420

Query: 217 PVVASVQAALHV--SRKERWRRSLVWRHVQYFASLTK------LNITSPIISIVVGSEEA 372
            ++A    ++ V  S + +  R    R+V+Y   L        +N  S II I VG+ E 
Sbjct: 421 MILAGALESVRVLKSPEGQLLRRAHQRNVKYMRQLLMDKGLPVVNCPSHIIPIRVGNAEL 480

Query: 373 ALRAGRHML-RSGFHVTPIRPPT 438
             +    +L +   +V  I  PT
Sbjct: 481 NTKVCDSLLEKHNIYVQAINYPT 503
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>HEM1_YARLI (Q6CCW0) 5-aminolevulinate synthase, mitochondrial precursor (EC|
           2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
          Length = 563

 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 46/155 (29%), Positives = 71/155 (45%), Gaps = 21/155 (13%)
 Frame = +1

Query: 37  GDNGGGVPELLECE---SG-----------IDISVGTLSKAAGCQGGFVACSTRWKSLIQ 174
           G  G GV E L+ E   SG           +DI  GTL KA GC GG++A S ++  +++
Sbjct: 337 GPTGAGVAEHLDFEHYHSGAQTQRQPIMDRVDIFTGTLGKAYGCVGGYIAGSAKFVDMVR 396

Query: 175 SRGRSFIFSTALPVPVVASVQAALHVSRKERWRRSLVWRHVQYF------ASLTKLNITS 336
           S    FIF+T LP   +A  +AA++  +     R     H +Y         +  +   S
Sbjct: 397 SYAPGFIFTTTLPPATMAGARAAINYQKATMKDRVAQQTHTRYVKDKLANRGIPVVPNPS 456

Query: 337 PIISIVVGSEEAALRAGRHML-RSGFHVTPIRPPT 438
            I+ ++VG  + A  A   +L +   +V  I  PT
Sbjct: 457 HIVPVLVGDAQKAKAASDLLLTKHQIYVQAINFPT 491
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>KBL_STAAC (Q5HIC5) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine C-acetyltransferase)
          Length = 395

 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 37/137 (27%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
 Frame = +1

Query: 46  GGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVV 225
           G G  +    +  ID  +GTLSKA G  GG+VA +      ++++ R F+FST+L     
Sbjct: 221 GAGTVKHFGLQDKIDFQIGTLSKAIGVVGGYVAGTKELIDWLKAQSRPFLFSTSLAPGDT 280

Query: 226 ASVQAALHVSRKERWRRSLVWRHVQYFAS-LTKLNI-----TSPIISIVVGSEEAALRAG 387
            ++  A+            +W + QY  + L+KL        +PI  +++G E+      
Sbjct: 281 KAITEAVKKLMDSTELHDKLWNNAQYLKNGLSKLGYDTGESETPITPVIIGDEKTTQEFS 340

Query: 388 RHMLRSGFHVTPIRPPT 438
           + +   G +V  I  PT
Sbjct: 341 KRLKDEGVYVKSIVFPT 357
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>HEM1_SCHPO (O14092) 5-aminolevulinate synthase, mitochondrial precursor (EC|
           2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
          Length = 558

 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 49/145 (33%), Positives = 70/145 (48%), Gaps = 11/145 (7%)
 Frame = +1

Query: 37  GDNGGGV----PELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFST 204
           G  G GV    P LL   S +DI  GTL+K+ GC GG++A S+    +I+S    FIF+T
Sbjct: 351 GPRGAGVAEETPGLL---SRVDIITGTLAKSYGCVGGYIAASSTLVDMIRSLAPGFIFTT 407

Query: 205 ALPVPVVASVQAA---LHVSRKERWRRSLVWRHVQYFAS---LTKLNITSPIISIVVGSE 366
           +LP  V+     A   L VS  ER ++    R V+   S   +  L+  + I+  +VG  
Sbjct: 408 SLPPHVMVGALTAVEHLKVSNVEREQQRSAVRRVKQSLSEIGIPVLSNDTHIVPAMVGDA 467

Query: 367 EAALRAGRHMLRS-GFHVTPIRPPT 438
             A  A   +L     +V  I  PT
Sbjct: 468 HLAKLASDSLLHDHNIYVQSINFPT 492
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>KBL_SHIFL (P0AB79) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine acetyltransferase)
          Length = 398

 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 7/135 (5%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKA-AGCQGGFVACSTRWKSLIQSRGRSFIFSTALP 213
           G+NG G  E  +    +DI  GTL KA  G  GG+ A        ++ R R ++FS +L 
Sbjct: 219 GENGRGSHEYCDVMGRVDIITGTLGKALGGASGGYTAARKEVVEWLRQRSRPYLFSNSLA 278

Query: 214 VPVVASVQAALHVSRKERWRRSLVWRHVQYF------ASLTKLNITSPIISIVVGSEEAA 375
             +VA+    L +       R  +W + + F      A  T       II +++G    A
Sbjct: 279 PAIVAASIKVLEMVEAGSELRDRLWANARQFREQMSAAGFTLAGADHAIIPVMLGDAVVA 338

Query: 376 LRAGRHMLRSGFHVT 420
            +  R + + G +VT
Sbjct: 339 QKFARELQKEGIYVT 353
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>KBL_SALTY (P37419) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine acetyltransferase)
          Length = 398

 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 7/135 (5%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKA-AGCQGGFVACSTRWKSLIQSRGRSFIFSTALP 213
           G+NG G  E  +    +DI  GTL KA  G  GG+ A        ++ R R ++FS +L 
Sbjct: 219 GENGRGSHEYCDVMGRVDIITGTLGKALGGASGGYTAARKEVVEWLRQRSRPYLFSNSLA 278

Query: 214 VPVVASVQAALHVSRKERWRRSLVWRHVQYF------ASLTKLNITSPIISIVVGSEEAA 375
             +VA+    L +       R  +W + + F      A  T       II +++G    A
Sbjct: 279 PAIVAASIKVLEMVEAGAELRDRLWANARQFREQMSAAGFTLAGADHAIIPVMLGDAVVA 338

Query: 376 LRAGRHMLRSGFHVT 420
            +  R + + G +VT
Sbjct: 339 QKFARELQKEGIYVT 353
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>KBL_ECOLI (P0AB77) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine acetyltransferase)
          Length = 398

 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 7/135 (5%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKA-AGCQGGFVACSTRWKSLIQSRGRSFIFSTALP 213
           G+NG G  E  +    +DI  GTL KA  G  GG+ A        ++ R R ++FS +L 
Sbjct: 219 GENGRGSHEYCDVMGRVDIITGTLGKALGGASGGYTAARKEVVEWLRQRSRPYLFSNSLA 278

Query: 214 VPVVASVQAALHVSRKERWRRSLVWRHVQYF------ASLTKLNITSPIISIVVGSEEAA 375
             +VA+    L +       R  +W + + F      A  T       II +++G    A
Sbjct: 279 PAIVAASIKVLEMVEAGSELRDRLWANARQFREQMSAAGFTLAGADHAIIPVMLGDAVVA 338

Query: 376 LRAGRHMLRSGFHVT 420
            +  R + + G +VT
Sbjct: 339 QKFARELQKEGIYVT 353
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>KBL_ECO57 (P0AB78) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine acetyltransferase)
          Length = 398

 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 7/135 (5%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKA-AGCQGGFVACSTRWKSLIQSRGRSFIFSTALP 213
           G+NG G  E  +    +DI  GTL KA  G  GG+ A        ++ R R ++FS +L 
Sbjct: 219 GENGRGSHEYCDVMGRVDIITGTLGKALGGASGGYTAARKEVVEWLRQRSRPYLFSNSLA 278

Query: 214 VPVVASVQAALHVSRKERWRRSLVWRHVQYF------ASLTKLNITSPIISIVVGSEEAA 375
             +VA+    L +       R  +W + + F      A  T       II +++G    A
Sbjct: 279 PAIVAASIKVLEMVEAGSELRDRLWANARQFREQMSAAGFTLAGADHAIIPVMLGDAVVA 338

Query: 376 LRAGRHMLRSGFHVT 420
            +  R + + G +VT
Sbjct: 339 QKFARELQKEGIYVT 353
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>KBL_STAAW (Q8NXY3) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine C-acetyltransferase)
          Length = 395

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 37/137 (27%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
 Frame = +1

Query: 46  GGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVV 225
           G G  +    +  ID  +GTLSKA G  GG+VA +      ++++ R F+FST+L     
Sbjct: 221 GAGTVKHFGLQDKIDFQIGTLSKAIGVVGGYVAGTKELIDWLKAQSRPFLFSTSLAPGDT 280

Query: 226 ASVQAALHVSRKERWRRSLVWRHVQYFAS-LTKLNI-----TSPIISIVVGSEEAALRAG 387
            ++  A+            +W + QY  + L+KL        +PI  +++G E+      
Sbjct: 281 KAITEAVKKLMDSTELHDKLWDNAQYLKNGLSKLGYDTGESETPITPVIIGDEKTTQEFS 340

Query: 388 RHMLRSGFHVTPIRPPT 438
           + +   G +V  I  PT
Sbjct: 341 KRLKDEGVYVKSIVFPT 357
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>KBL_STAAS (Q6GBT7) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine C-acetyltransferase)
          Length = 395

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 37/137 (27%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
 Frame = +1

Query: 46  GGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVV 225
           G G  +    +  ID  +GTLSKA G  GG+VA +      ++++ R F+FST+L     
Sbjct: 221 GAGTVKHFGLQDKIDFQIGTLSKAIGVVGGYVAGTKELIDWLKAQSRPFLFSTSLAPGDT 280

Query: 226 ASVQAALHVSRKERWRRSLVWRHVQYFAS-LTKLNI-----TSPIISIVVGSEEAALRAG 387
            ++  A+            +W + QY  + L+KL        +PI  +++G E+      
Sbjct: 281 KAITEAVKKLMDSTELHDKLWDNAQYLKNGLSKLGYDTGESETPITPVIIGDEKTTQEFS 340

Query: 388 RHMLRSGFHVTPIRPPT 438
           + +   G +V  I  PT
Sbjct: 341 KRLKDEGVYVKSIVFPT 357
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>KBL_STAAR (Q6GJB8) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine C-acetyltransferase)
          Length = 395

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 37/137 (27%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
 Frame = +1

Query: 46  GGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVV 225
           G G  +    +  ID  +GTLSKA G  GG+VA +      ++++ R F+FST+L     
Sbjct: 221 GAGTVKHFGLQDKIDFQIGTLSKAIGVVGGYVAGTKELIDWLKAQSRPFLFSTSLAPGDT 280

Query: 226 ASVQAALHVSRKERWRRSLVWRHVQYFAS-LTKLNI-----TSPIISIVVGSEEAALRAG 387
            ++  A+            +W + QY  + L+KL        +PI  +++G E+      
Sbjct: 281 KAITEAVKKLMASTELHDKLWDNAQYLKNGLSKLGYDTGESETPITPVIIGEEKTTQEFS 340

Query: 388 RHMLRSGFHVTPIRPPT 438
           + +   G +V  I  PT
Sbjct: 341 KRLKDEGVYVKSIVFPT 357
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>KBL_STAAN (P60120) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine C-acetyltransferase)
          Length = 395

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 37/137 (27%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
 Frame = +1

Query: 46  GGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVV 225
           G G  +    +  ID  +GTLSKA G  GG+VA +      ++++ R F+FST+L     
Sbjct: 221 GAGTVKHFGLQDKIDFQIGTLSKAIGVVGGYVAGTKELIDWLKAQSRPFLFSTSLAPGDT 280

Query: 226 ASVQAALHVSRKERWRRSLVWRHVQYFAS-LTKLNI-----TSPIISIVVGSEEAALRAG 387
            ++  A+            +W + QY  + L+KL        +PI  +++G E+      
Sbjct: 281 KAITEAVKKLMDSTELHDKLWDNAQYLKNGLSKLGYDTGESETPITPVIIGDEKTTQEFS 340

Query: 388 RHMLRSGFHVTPIRPPT 438
           + +   G +V  I  PT
Sbjct: 341 KRLKDEGVYVKSIVFPT 357
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>KBL_STAAM (P60121) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine C-acetyltransferase)
          Length = 395

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 37/137 (27%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
 Frame = +1

Query: 46  GGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVV 225
           G G  +    +  ID  +GTLSKA G  GG+VA +      ++++ R F+FST+L     
Sbjct: 221 GAGTVKHFGLQDKIDFQIGTLSKAIGVVGGYVAGTKELIDWLKAQSRPFLFSTSLAPGDT 280

Query: 226 ASVQAALHVSRKERWRRSLVWRHVQYFAS-LTKLNI-----TSPIISIVVGSEEAALRAG 387
            ++  A+            +W + QY  + L+KL        +PI  +++G E+      
Sbjct: 281 KAITEAVKKLMDSTELHDKLWDNAQYLKNGLSKLGYDTGESETPITPVIIGDEKTTQEFS 340

Query: 388 RHMLRSGFHVTPIRPPT 438
           + +   G +V  I  PT
Sbjct: 341 KRLKDEGVYVKSIVFPT 357
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>HEM1_RHOCA (P18079) 5-aminolevulinate synthase (EC 2.3.1.37) (5-aminolevulinic|
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase)
          Length = 401

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 46/144 (31%), Positives = 67/144 (46%), Gaps = 10/144 (6%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  G GV E       IDI  GTL+KA G  GG++A S +    ++S    FIFST+LP 
Sbjct: 223 GPRGAGVAERDGLMHRIDIFNGTLAKAYGVFGGYIAASAKMVDAVRSYAPGFIFSTSLPP 282

Query: 217 PVVASVQAALHVSRKERWR--RSLVWRHVQYFASLTK------LNITSPIISIVVGSEEA 372
            + A  QA++   +    +  R     H +      K      ++  S I+ +V+G +  
Sbjct: 283 AIAAGAQASIAFLKTAEGQKLRDAQQMHAKVLKMRLKALGMPIIDHGSHIVPVVIG-DPV 341

Query: 373 ALRAGRHMLRS--GFHVTPIRPPT 438
             +A   ML S  G +V PI  PT
Sbjct: 342 HTKAVSDMLLSDYGVYVQPINFPT 365
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>BIOF_AQUAE (O66875) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 373

 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 39/123 (31%), Positives = 61/123 (49%), Gaps = 7/123 (5%)
 Frame = +1

Query: 91  ISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVVASVQAALHVSRKE-- 264
           I +GTLSKA G  G FV  +      + ++ RS IFST+LP  V A  + A+ +  +   
Sbjct: 216 IVMGTLSKALGSYGAFVCGTKLLIDYLVNKARSLIFSTSLPPSVCAGAKKAIEIIEENPK 275

Query: 265 -----RWRRSLVWRHVQYFASLTKLNITSPIISIVVGSEEAALRAGRHMLRSGFHVTPIR 429
                R +   +   ++ F SL     ++PII I+V  E+  +R    +L+ G  +  IR
Sbjct: 276 LIEFLRKKEKEILEILEQF-SLDYKYYSTPIIPIMVYDEKETVRIKEELLKEGVFIQAIR 334

Query: 430 PPT 438
            PT
Sbjct: 335 YPT 337
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>HEM0_BRARE (Q9YHT4) 5-aminolevulinate synthase, erythroid-specific,|
           mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase) (ALAS-E)
          Length = 583

 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 40/117 (34%), Positives = 59/117 (50%), Gaps = 8/117 (6%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G +G GV E       IDI  GTL KA GC GG++A +      ++S    FIF+T+LP 
Sbjct: 361 GAHGAGVGERDNVMHKIDIVSGTLGKAFGCVGGYIASTAALVDTVRSFAAGFIFTTSLPP 420

Query: 217 PVVASVQAALHVSRKERWR--RSLVWRHVQYF------ASLTKLNITSPIISIVVGS 363
            V+A    ++ V + +  +  R    R+V++       A L  +N  S II I VG+
Sbjct: 421 MVLAGALESVRVLKSDEGQALRRAHQRNVKHMRQLLLDAGLPVVNCPSHIIPIRVGN 477
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>HEM1_RHOS4 (Q04512) 5-aminolevulinate synthase 1 (EC 2.3.1.37)|
           (5-aminolevulinic acid synthase) (Delta-aminolevulinate
           synthase) (Delta-ALA synthetase)
          Length = 407

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 33/69 (47%), Positives = 41/69 (59%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  GGGV E       IDI  GTL KA G  GG++A S++    ++S    FIFST+LP 
Sbjct: 223 GPRGGGVAERDGLMDRIDIINGTLGKAYGVFGGYIAASSKMCDAVRSYAPGFIFSTSLP- 281

Query: 217 PVVASVQAA 243
           PVVA+  AA
Sbjct: 282 PVVAAGAAA 290
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>HEM1_ASHGO (Q75DX7) 5-aminolevulinate synthase, mitochondrial precursor (EC|
           2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
          Length = 556

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 45/157 (28%), Positives = 71/157 (45%), Gaps = 23/157 (14%)
 Frame = +1

Query: 37  GDNGGGVPELLECESG----------------IDISVGTLSKAAGCQGGFVACSTRWKSL 168
           G +G GV E L+ E+                 +D+   TL K+ G  GG++A S +    
Sbjct: 304 GPHGAGVAEHLDFEAHRKAGLASPAQTTVLDRVDMITATLGKSFGSVGGYLAASEKLVDF 363

Query: 169 IQSRGRSFIFSTALPVPVVASVQAALHVSRKERWRRSLVWRHVQYF-ASLTKLNI----- 330
           ++S    FIF+++LP  V+A   AA+   R     R L  +H  Y    L  L I     
Sbjct: 364 VRSYAPGFIFTSSLPPAVMAGSAAAVFDQRSSLHLRQLQQKHTSYVKTGLGDLGIPVQPN 423

Query: 331 TSPIISIVVGSEEAALRAGRHML-RSGFHVTPIRPPT 438
            S I+ ++VG+ + A RA   ++ +   +V  I  PT
Sbjct: 424 PSHIVPVLVGNPDLAKRASDILMEKHRIYVQAINFPT 460
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>HEM1_DELLE (Q9XS79) 5-aminolevulinate synthase, nonspecific, mitochondrial|
           precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
           (ALAS-H)
          Length = 640

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 42/143 (29%), Positives = 66/143 (46%), Gaps = 9/143 (6%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  GGG+ +       +DI  GTL KA GC GG++A ++     I+S    FIF+T+LP 
Sbjct: 420 GAQGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTIRSYAAGFIFTTSLPP 479

Query: 217 PVVASVQAAL--------HVSRKERWRRSLVWRHVQYFASLTKLNITSPIISI-VVGSEE 369
            ++A    ++         V R++  R   + R +   ASL  ++  S II + V  + +
Sbjct: 480 MLLAGALESVRILKSTEGRVLRRQHQRNVKLMRQMLMDASLPVVHCPSHIIPVRVADAAK 539

Query: 370 AALRAGRHMLRSGFHVTPIRPPT 438
                   M R   +V  I  PT
Sbjct: 540 NTEVCNELMSRHNIYVQAINYPT 562
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>KBL_OCEIH (Q8EM07) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine C-acetyltransferase)
          Length = 396

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 42/143 (29%), Positives = 66/143 (46%), Gaps = 7/143 (4%)
 Frame = +1

Query: 31  VCGDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTAL 210
           V GD G G  +    +  +D+ +GTLSKA G  GG+VA        ++ R R F+FSTA+
Sbjct: 218 VTGD-GAGTVKHFGLQDKVDMQMGTLSKAIGVIGGYVAGKQSLIDWLKVRSRPFLFSTAV 276

Query: 211 -PVPVVASVQAALHVSRKERWRRSLVWRHVQYF-ASLTKLNI-----TSPIISIVVGSEE 369
            P   VAS + A+ +  +       +W +  Y    L +L        +PI   ++G E+
Sbjct: 277 SPADAVAS-KRAIEMLMESTELNEKLWENGDYLKQGLKELGFDIGESETPITPCIIGDEK 335

Query: 370 AALRAGRHMLRSGFHVTPIRPPT 438
            A    + +   G +   I  PT
Sbjct: 336 KAQEFSKRLYEEGVYAKSIVFPT 358
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>HEM1_CANGA (Q6FXE3) 5-aminolevulinate synthase, mitochondrial precursor (EC|
           2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
          Length = 530

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 43/141 (30%), Positives = 65/141 (46%), Gaps = 7/141 (4%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           GDNG     L      +D+  GTL K+ G  GG+VA S++    ++S    FIF+T LP 
Sbjct: 298 GDNG----RLRTVMDRVDMITGTLGKSFGTVGGYVAASSKLIDWVRSYAPGFIFTTTLPP 353

Query: 217 PVVASVQAALHVSRKERWRRSLVWRHVQYF-ASLTKLNI-----TSPIISIVVGSEEAAL 378
            V+A    A+   R     R    RH  Y    L  L I      S I+ +++G+ + A 
Sbjct: 354 AVMAGAAEAIRFQRSHLNLRQDQQRHTAYVKKGLHDLGIPVIPNPSHIVPVLIGNPDLAK 413

Query: 379 RAGRHML-RSGFHVTPIRPPT 438
           +A   ++ +   +V  I  PT
Sbjct: 414 QASDILMEKHRIYVQAINFPT 434
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>HEM0_CHICK (P18080) 5-aminolevulinate synthase, erythroid-specific,|
           mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase) (ALAS-E)
          Length = 513

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 45/140 (32%), Positives = 62/140 (44%), Gaps = 6/140 (4%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  G G+ E    +  +D+  GTL KA G  GG++A S      ++S G  FIF+TALP 
Sbjct: 298 GARGAGIAERDGVQHKVDVVSGTLGKALGAVGGYIAGSEALVDAVRSLGPGFIFTTALPP 357

Query: 217 PVVASVQAALHV--SRKERWRRSLVWRHVQYFASLTKLNITSPIISIVV---GSEEAALR 381
                  AAL V  S +    R    RH ++   L +      + S +V      EA  R
Sbjct: 358 QRGGGALAALQVVGSAEGAALRRAHQRHAKHLRVLLRDRGLPALPSHIVPVRWDAEANTR 417

Query: 382 AGRHMLRS-GFHVTPIRPPT 438
             R +L   G +V  I  PT
Sbjct: 418 LSRALLEEHGLYVQAINHPT 437
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>HEM1_PARDE (P43089) 5-aminolevulinate synthase (EC 2.3.1.37) (5-aminolevulinic|
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase)
          Length = 409

 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 30/70 (42%), Positives = 38/70 (54%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  GGGV E       IDI  GTL+KA G  GG++    R    I+S    FIF+T+LP 
Sbjct: 223 GPRGGGVAERDGLSHRIDIFNGTLAKAFGVFGGYIGFGARMVDAIRSYAPGFIFTTSLPP 282

Query: 217 PVVASVQAAL 246
            V A V A++
Sbjct: 283 AVAAGVAASI 292
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>HEM1_OPSTA (P43091) 5-aminolevulinate synthase, nonspecific, mitochondrial|
           precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
           (ALAS-H)
          Length = 627

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 39/143 (27%), Positives = 65/143 (45%), Gaps = 9/143 (6%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  GGG+ +       +DI  GTL KA GC GG++A +      ++S    FIF+T+LP 
Sbjct: 407 GPRGGGIGDRDGIMHKMDIISGTLGKAFGCVGGYIASTATLVDTVRSYAAGFIFTTSLPP 466

Query: 217 PVVASVQAALHV--------SRKERWRRSLVWRHVQYFASLTKLNITSPIISIVVGSEEA 372
            ++A  + ++ +         R++  R   + R +   + L  ++  S II I V   E 
Sbjct: 467 MLLAGAKQSIQILKGEEGCTLRRKHQRNVKLLRQMLMDSGLPVVHCPSHIIPIRVSDAEK 526

Query: 373 ALRAGRHML-RSGFHVTPIRPPT 438
             +    M+     +V  I  PT
Sbjct: 527 NTKVCDLMMSHHNIYVQAINYPT 549
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>HEM1_AGRRD (P26505) 5-aminolevulinate synthase (EC 2.3.1.37) (5-aminolevulinic|
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase)
          Length = 405

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 42/141 (29%), Positives = 62/141 (43%), Gaps = 7/141 (4%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  GGG+ E       + I  GTL KA G  GG++  ST     I+S    FIF+TALP 
Sbjct: 223 GPRGGGIAEREGLMDRLTIIEGTLGKAFGVMGGYITGSTAVCDFIRSFASGFIFTTALPP 282

Query: 217 PVVASVQAALHVSRKERWRRSLVWRHVQYFASL------TKLNITSPIISIVVGSEEAAL 378
            + A   A++   +   + R+     V+    L        ++  S I+ ++VG      
Sbjct: 283 SLAAGAIASIQHLKASPFERARHQDRVRKLRGLLDARGIPHMDNPSHIVPVMVGDAAKCK 342

Query: 379 RAGRHMLRS-GFHVTPIRPPT 438
                +L S G +V PI  PT
Sbjct: 343 WISDILLDSHGVYVQPINYPT 363
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>HEM1_RAT (P13195) 5-aminolevulinate synthase, nonspecific, mitochondrial|
           precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
           (ALAS-H)
          Length = 642

 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 39/143 (27%), Positives = 66/143 (46%), Gaps = 9/143 (6%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G +GGG+ +       +DI  GTL KA GC GG++A ++     ++S    FIF+T+LP 
Sbjct: 422 GASGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYAAGFIFTTSLPP 481

Query: 217 PVVASVQAALHV--------SRKERWRRSLVWRHVQYFASLTKLNITSPIISI-VVGSEE 369
            ++A    ++ +         R++  R   + R +   A L  ++  S II + V  + +
Sbjct: 482 MLLAGALESVRILKSNEGRALRRQHQRNVKLMRQMLMDAGLPVIHCPSHIIPVRVADAAK 541

Query: 370 AALRAGRHMLRSGFHVTPIRPPT 438
                   M R   +V  I  PT
Sbjct: 542 NTEICDELMTRHNIYVQAINYPT 564
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>HEM0_RHOS4 (Q06965) 5-aminolevulinate synthase 2 (EC 2.3.1.37)|
           (5-aminolevulinic acid synthase) (Delta-aminolevulinate
           synthase) (Delta-ALA synthetase)
          Length = 407

 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 41/141 (29%), Positives = 67/141 (47%), Gaps = 7/141 (4%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  GGG+ +       + I  GTL+KA G  GG+V+  +    +I+S   SFIF+T++  
Sbjct: 223 GPRGGGISDRDGLADRVTIIEGTLAKAFGVMGGYVSGPSLLMDVIRSMSDSFIFTTSICP 282

Query: 217 PVVASVQAAL-HV-----SRKERWRRSLVWRHVQYFASLTKLNITSPIISIVVGSEEAAL 378
            + A   AA+ HV      R+ +   ++  + +   A L  L+  S I+ ++VG      
Sbjct: 283 HLAAGALAAVRHVKAHPDERRRQAENAVRLKVLLQKAGLPVLDTPSHILPVMVGEAHLCR 342

Query: 379 RAGRHML-RSGFHVTPIRPPT 438
                +L R   +V PI  PT
Sbjct: 343 SISEALLARHAIYVQPINYPT 363
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>HEM0_DELLE (Q9XT75) 5-aminolevulinate synthase, erythroid-specific,|
           mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase) (ALAS-E)
          Length = 582

 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 43/143 (30%), Positives = 66/143 (46%), Gaps = 9/143 (6%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  G G+ E       IDI  GTL KA GC GG++A +     +++S    FIF+T+LP 
Sbjct: 361 GSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 420

Query: 217 PVVASVQAALHVSRKERWR--RSLVWRHVQYFASLTK------LNITSPIISIVVGSEEA 372
            V++    ++ + + E  +  R    R+V++   L        +   S II I VG    
Sbjct: 421 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGDAAL 480

Query: 373 ALRAGRHML-RSGFHVTPIRPPT 438
             R    +L + G +V  I  PT
Sbjct: 481 NSRICDLLLSKHGIYVQAINYPT 503
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>HEM1_HUMAN (P13196) 5-aminolevulinate synthase, nonspecific, mitochondrial|
           precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
           (ALAS-H)
          Length = 640

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 41/143 (28%), Positives = 64/143 (44%), Gaps = 9/143 (6%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  GGG+ +       +DI  GTL KA GC GG++A ++     ++S    FIF+T+LP 
Sbjct: 420 GARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPP 479

Query: 217 PVVASV--------QAALHVSRKERWRRSLVWRHVQYFASLTKLNITSPIISI-VVGSEE 369
            ++A           A   V R++  R   + R +   A L  ++  S II + V  + +
Sbjct: 480 MLLAGALESVRILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAK 539

Query: 370 AALRAGRHMLRSGFHVTPIRPPT 438
                   M R   +V  I  PT
Sbjct: 540 NTEVCDELMSRHNIYVQAINYPT 562
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>KBL_BACCR (Q81I05) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine C-acetyltransferase)
          Length = 396

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 36/137 (26%), Positives = 57/137 (41%), Gaps = 6/137 (4%)
 Frame = +1

Query: 46  GGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVV 225
           G G  +       +D  +GTLSKA G  GG+VA        ++ R R F+FSTAL     
Sbjct: 222 GAGTVKHFGLSDKVDFQIGTLSKAIGVIGGYVAGKQNLIDWLKVRSRPFLFSTALTPADA 281

Query: 226 ASVQAALHVSRKERWRRSLVWRHVQYFASLTK---LNI---TSPIISIVVGSEEAALRAG 387
           A+   ++ +  +       +W + +Y     K    NI    +PI   ++G E       
Sbjct: 282 AACMRSIEILMESTELHDRLWENGRYLKQGLKELGFNIGESETPITPCIIGDEVLTQEFS 341

Query: 388 RHMLRSGFHVTPIRPPT 438
           + +   G +   I  PT
Sbjct: 342 KRLNEEGVYAKSIVFPT 358
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>BIOF_ENTAG (Q47829) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 385

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 45/144 (31%), Positives = 64/144 (44%), Gaps = 8/144 (5%)
 Frame = +1

Query: 31  VCGDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTAL 210
           V G  G G  +  E +   ++ V T  K  G  G  V CS    +  +   R  I+ST++
Sbjct: 211 VTGHKGRGSCQQQEVKP--ELLVVTFGKGFGVSGAAVLCSEAVATYFEQFARHLIYSTSM 268

Query: 211 PVPVVASVQAALHVSRKER--WRRSLVWRHVQYF---ASLTKLNIT---SPIISIVVGSE 366
           P     ++ AAL V R E    RR+ +   +Q F   A+     IT   S I  ++VG  
Sbjct: 269 PPAQAVALSAALSVIRGEEGDQRRTALAGLIQRFRHGAAALPGRITHSQSAIQPLIVGDN 328

Query: 367 EAALRAGRHMLRSGFHVTPIRPPT 438
             AL     + + G  VT IRPPT
Sbjct: 329 SRALSLAERLRQKGCWVTAIRPPT 352
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>HEM1_MOUSE (Q8VC19) 5-aminolevulinate synthase, nonspecific, mitochondrial|
           precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
           (ALAS-H)
          Length = 642

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 39/143 (27%), Positives = 65/143 (45%), Gaps = 9/143 (6%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  GGG+ +       +DI  GTL KA GC GG++A ++     ++S    FIF+T+LP 
Sbjct: 422 GARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYAAGFIFTTSLPP 481

Query: 217 PVVASVQAALHV--------SRKERWRRSLVWRHVQYFASLTKLNITSPIISI-VVGSEE 369
            ++A    ++ +         R++  R   + R +   A L  ++  S II + V  + +
Sbjct: 482 MLLAGALESVRILKSSEGRALRRQHQRNVKLLRQMLMDAGLPVIHCPSHIIPVRVADAAK 541

Query: 370 AALRAGRHMLRSGFHVTPIRPPT 438
                   M R   +V  I  PT
Sbjct: 542 NTEICDELMTRHNIYVQAINYPT 564
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>HEM1_RHIME (P08080) 5-aminolevulinate synthase (EC 2.3.1.37) (5-aminolevulinic|
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase)
          Length = 404

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 42/147 (28%), Positives = 61/147 (41%), Gaps = 13/147 (8%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  GGG+ E       + +  GTL KA G  GG++  S      I+S    FIF+TALP 
Sbjct: 222 GPRGGGIAEREGLMHRLTVIEGTLGKAFGVMGGYITGSAALCDFIRSFASGFIFTTALPP 281

Query: 217 PVVASVQAAL------------HVSRKERWRRSLVWRHVQYFASLTKLNITSPIISIVVG 360
            + A   A++            H  R  R R  L  R + +  +       S I+ ++VG
Sbjct: 282 ALAAGALASIRHLKESQVERFAHQERVRRLRSLLDQRGIPHMVN------PSHIVPVIVG 335

Query: 361 SEEAALRAGRHMLRS-GFHVTPIRPPT 438
                      +L + G +V PI  PT
Sbjct: 336 DAAKCKWISDLLLDNFGIYVQPINYPT 362
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>HEM1_KLULA (P78698) 5-aminolevulinate synthase, mitochondrial precursor (EC|
           2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
          Length = 570

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 41/134 (30%), Positives = 60/134 (44%), Gaps = 7/134 (5%)
 Frame = +1

Query: 58  PELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVVASVQ 237
           PE       +D+  GTL K+ G  GG+VA S +    ++S    FIF+T LP  V+A   
Sbjct: 341 PEFRTVMDRVDMITGTLGKSFGTVGGYVAGSLQLIDWVRSYAPGFIFTTTLPPAVMAGAA 400

Query: 238 AALHVSRKERWRRSLVWRHVQYFA-SLTKLNI-----TSPIISIVVGSEEAALRAGRHML 399
            A+   R     R    RH  Y    L  L I      S I+ ++VG+   A +A   ++
Sbjct: 401 EAIRYQRSHLDLRQDQQRHTTYVKDGLADLGIPVMPNPSHIVPVLVGNPHLAKQASDILM 460

Query: 400 -RSGFHVTPIRPPT 438
            +   +V  I  PT
Sbjct: 461 DKHRIYVQAINFPT 474
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>HEM0_HUMAN (P22557) 5-aminolevulinate synthase, erythroid-specific,|
           mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase) (ALAS-E)
          Length = 587

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 44/145 (30%), Positives = 69/145 (47%), Gaps = 11/145 (7%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  G G+ E       IDI  GTL KA GC GG++A +     +++S    FIF+T+LP 
Sbjct: 366 GSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 425

Query: 217 PVVASVQAALHVSRKERWR--RSLVWRHVQYFASLTK------LNITSPIISIVVGSEEA 372
            V++    ++ + + E  +  R    R+V++   L        +   S II I VG+  A
Sbjct: 426 MVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGN--A 483

Query: 373 ALRA---GRHMLRSGFHVTPIRPPT 438
           AL +      + + G +V  I  PT
Sbjct: 484 ALNSKLCDLLLSKHGIYVQAINYPT 508
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>HEM1_CANAL (O94069) 5-aminolevulinate synthase, mitochondrial precursor (EC|
           2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
          Length = 564

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 42/136 (30%), Positives = 66/136 (48%), Gaps = 9/136 (6%)
 Frame = +1

Query: 58  PELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVVASVQ 237
           PE+    S +D+  GTL KA G  GG++   T      +S    FIF+T+LP  ++A   
Sbjct: 335 PEITTVMSRVDMVTGTLGKAYGVVGGYITGKTNLIDWFRSYAPGFIFTTSLPPAIMAGCS 394

Query: 238 AALHVSR---KERWRRSLVWRHVQYFASLTKLNI-----TSPIISIVVGSEEAALRAGRH 393
           A++   R   K+R  +    R V+   +L +L I      S I+ ++VG+   A RA   
Sbjct: 395 ASIRYQRATLKDRIAQQKNTRLVK--NNLNELGIPVIPNPSHIVPVLVGNAADAKRASDL 452

Query: 394 ML-RSGFHVTPIRPPT 438
           +L +   +V  I  PT
Sbjct: 453 LLNKHDIYVQAINFPT 468
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>KBL_BACAN (Q81V80) 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29)|
           (AKB ligase) (Glycine C-acetyltransferase)
          Length = 396

 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 35/137 (25%), Positives = 57/137 (41%), Gaps = 6/137 (4%)
 Frame = +1

Query: 46  GGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVV 225
           G G  +       +D  +GTLSKA G  GG+VA        ++ R R F+FSTA+     
Sbjct: 222 GAGTVKHFGLSDKVDFQIGTLSKAIGVIGGYVAGKQNLIDWLKVRSRPFLFSTAVTPADA 281

Query: 226 ASVQAALHVSRKERWRRSLVWRHVQYFASLTK---LNI---TSPIISIVVGSEEAALRAG 387
           A+   ++ +  +       +W + +Y     K    NI    +PI   ++G E       
Sbjct: 282 AACMRSIEILMESTELHDRLWENGRYLKQGLKELGFNIGESETPITPCIIGDEVLTQEFS 341

Query: 388 RHMLRSGFHVTPIRPPT 438
           + +   G +   I  PT
Sbjct: 342 KRLNEEGVYAKSIVFPT 358
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>HEM1_AGABI (Q92403) 5-aminolevulinate synthase, mitochondrial precursor (EC|
           2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
          Length = 621

 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 40/125 (32%), Positives = 62/125 (49%), Gaps = 7/125 (5%)
 Frame = +1

Query: 85  IDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVVASVQAALHVSRKE 264
           IDI  GTL K+ G  GG++A S  +  +I+S    FIF+T+LP   VA  +A++    + 
Sbjct: 353 IDIITGTLGKSYGAVGGYIAGSEEFVDMIRSYAPGFIFTTSLPPATVAGARASIVYQSEY 412

Query: 265 RWRRSLVWRHV-QYFASLTKLNI-----TSPIISIVVGSEEAALRAGRHML-RSGFHVTP 423
              R L   +V +    L +L+I     +S I+ ++VG    A  A   +L     +V  
Sbjct: 413 LGDRQLKQINVREVKRRLAELDIPVVPGSSHIVPVLVGDAALARAASDKLLSEHDIYVQA 472

Query: 424 IRPPT 438
           I  PT
Sbjct: 473 INYPT 477
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>HEM1_YEAST (P09950) 5-aminolevulinate synthase, mitochondrial precursor (EC|
           2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
          Length = 548

 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 38/125 (30%), Positives = 61/125 (48%), Gaps = 7/125 (5%)
 Frame = +1

Query: 85  IDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVVASVQAALHVSRKE 264
           +D+  GTL K+ G  GG+VA S +     +S    FIF+T LP  V+A   AA+   R  
Sbjct: 328 VDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCH 387

Query: 265 RWRRSLVWRHVQY----FASLTKLNITSP--IISIVVGSEEAALRAGRHML-RSGFHVTP 423
              R+   +H  Y    F  L    I +P  I+ +++G+ + A +A   ++ +   +V  
Sbjct: 388 IDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQASDILINKHQIYVQA 447

Query: 424 IRPPT 438
           I  PT
Sbjct: 448 INFPT 452
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>BIOF_ECOLI (P12998) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 384

 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 42/146 (28%), Positives = 65/146 (44%), Gaps = 8/146 (5%)
 Frame = +1

Query: 25  TLVCGDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFST 204
           T V G+ G G   L + +   ++ V T  K  G  G  V CS+     +    R  I+ST
Sbjct: 209 TGVIGEQGRGSCWLQKVKP--ELLVVTFGKGFGVSGAAVLCSSTVADYLLQFARHLIYST 266

Query: 205 ALPVPVVASVQAALHVSRKERW---RRSLVWRHVQYFASLTKLNIT-----SPIISIVVG 360
           ++P     +++A+L V R +     R  L     ++ A +  L  T     S I  ++VG
Sbjct: 267 SMPPAQAQALRASLAVIRSDEGDARREKLAALITRFRAGVQDLPFTLADSCSAIQPLIVG 326

Query: 361 SEEAALRAGRHMLRSGFHVTPIRPPT 438
               AL+    + + G  VT IRPPT
Sbjct: 327 DNSRALQLAEKLRQQGCWVTAIRPPT 352
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>BIOF_BUCBP (Q89AK6) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 384

 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 41/143 (28%), Positives = 63/143 (44%), Gaps = 7/143 (4%)
 Frame = +1

Query: 31  VCGDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTAL 210
           V G NG G  E    +   DI   T  KA G  G  V CS      +    +  +FSTA+
Sbjct: 211 VSGYNGKGSCEQHRVKP--DILTITFGKAFGISGAAVLCSNNIAEYLWQFSKHLMFSTAM 268

Query: 211 PVPVVASVQAALH-VSRKERWRRSL------VWRHVQYFASLTKLNITSPIISIVVGSEE 369
           P+    +++ AL+ +   ++ RR L        ++ Q  + L K + T+ I  I++G  E
Sbjct: 269 PIAQAYAIRQALYCIQHADKLRRKLQENINFFLKNSQCLSHLLKCSHTA-IQPIIIGDNE 327

Query: 370 AALRAGRHMLRSGFHVTPIRPPT 438
             +     +   G  V  IRPPT
Sbjct: 328 ETMILSDQLKSKGIWVNAIRPPT 350
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>BIOF_SERMA (P36570) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 382

 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 35/123 (28%), Positives = 56/123 (45%), Gaps = 6/123 (4%)
 Frame = +1

Query: 88  DISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVVASVQAALHVSRKER 267
           ++ V T  KA G  G  V C       +    R  I+STA+P     ++QAAL   R+  
Sbjct: 227 ELLVATFGKAFGVSGAAVLCDEATAEYLLQFARHLIYSTAMPPAQACALQAALARIREGD 286

Query: 268 WRRSLVWRHVQYF------ASLTKLNITSPIISIVVGSEEAALRAGRHMLRSGFHVTPIR 429
             R+ +  +++ F       +LT  +  + I  ++VG  + AL     +   G  V+ IR
Sbjct: 287 DLRARLQDNIRRFRQGAAPLALTLTDSDTAIQPLLVGDNQRALDLATRLRECGLWVSAIR 346

Query: 430 PPT 438
           PPT
Sbjct: 347 PPT 349
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>HEM0_RAT (Q63147) 5-aminolevulinate synthase, erythroid-specific,|
           mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase) (ALAS-E)
          Length = 587

 Score = 48.1 bits (113), Expect = 9e-06
 Identities = 25/76 (32%), Positives = 41/76 (53%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  G G+ E       +DI  GTL KA GC GG++A +     +++S    FIF+T+LP 
Sbjct: 366 GTRGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 425

Query: 217 PVVASVQAALHVSRKE 264
            V++    ++ + + E
Sbjct: 426 MVLSGALESVRLLKGE 441
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>HEM0_MOUSE (P08680) 5-aminolevulinate synthase, erythroid-specific,|
           mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic
           acid synthase) (Delta-aminolevulinate synthase)
           (Delta-ALA synthetase) (ALAS-E)
          Length = 587

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 25/76 (32%), Positives = 41/76 (53%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  G G+ E       +DI  GTL KA GC GG++A +     +++S    FIF+T+LP 
Sbjct: 366 GARGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPP 425

Query: 217 PVVASVQAALHVSRKE 264
            V++    ++ + + E
Sbjct: 426 MVLSGALESVRLLKGE 441
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>HEM1_CHICK (P07997) 5-aminolevulinate synthase, nonspecific, mitochondrial|
           precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
           (ALAS-H)
          Length = 635

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 39/143 (27%), Positives = 64/143 (44%), Gaps = 9/143 (6%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPV 216
           G  GGG+ +       +DI  GTL KA  C GG+++ ++     ++S    FIF+T+LP 
Sbjct: 415 GARGGGIGDRDGVMHKMDIISGTLGKAFACVGGYISSTSALIDTVRSYAAGFIFTTSLPP 474

Query: 217 PVVASV--------QAALHVSRKERWRRSLVWRHVQYFASLTKLNITSPIISI-VVGSEE 369
            ++A           A   V R++  R   + R +   A L  ++  S II I V  + +
Sbjct: 475 MLLAGALESVRTLKSAEGQVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPIRVADAAK 534

Query: 370 AALRAGRHMLRSGFHVTPIRPPT 438
                 + M +   +V  I  PT
Sbjct: 535 NTEICDKLMSQHSIYVQAINYPT 557
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>BIOF_METJA (Q58694) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 372

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 42/143 (29%), Positives = 59/143 (41%), Gaps = 5/143 (3%)
 Frame = +1

Query: 25  TLVCGDNGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFST 204
           T V GD  G +       S   + +GTLSKA G  GGFV         + +  RSFIFST
Sbjct: 197 TGVLGDGRGTLKHFNLKPSDNIVQIGTLSKAIGGLGGFVCGIEEVVEYLINTSRSFIFST 256

Query: 205 ALPVPVVASVQAALHVSRKERWRRSL-----VWRHVQYFASLTKLNITSPIISIVVGSEE 369
           ALP  VV     A  +  K    + L     +   V       K +  +PI   +   +E
Sbjct: 257 ALPPHVVEGCIKAFEIIEKTDIVKKLQKNIKIANKVFKKYEFIKEDNLTPIYPFIF--KE 314

Query: 370 AALRAGRHMLRSGFHVTPIRPPT 438
             +    H++++      IR PT
Sbjct: 315 KTMEIAEHLIKNNIFCVGIRYPT 337
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>KBL_HUMAN (O75600) 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial|
           precursor (EC 2.3.1.29) (AKB ligase) (Glycine
           acetyltransferase)
          Length = 419

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 38/134 (28%), Positives = 55/134 (41%), Gaps = 7/134 (5%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKA-AGCQGGFVACSTRWKSLIQSRGRSFIFSTALP 213
           G  G G  ELL     + I   TL KA  G  GG+        SL++ R R ++FS +LP
Sbjct: 240 GPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFSNSLP 299

Query: 214 VPVVASVQAALHVSR------KERWRRSLVWRHVQYFASLTKLNITSPIISIVVGSEEAA 375
             VV     AL +        +    ++  +R     A  T    + PI  +++G    A
Sbjct: 300 PAVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLA 359

Query: 376 LRAGRHMLRSGFHV 417
            R    ML+ G  V
Sbjct: 360 SRMADDMLKRGIFV 373
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>KBL_MOUSE (O88986) 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial|
           precursor (EC 2.3.1.29) (AKB ligase) (Glycine
           acetyltransferase)
          Length = 416

 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 39/137 (28%), Positives = 55/137 (40%), Gaps = 10/137 (7%)
 Frame = +1

Query: 37  GDNGGGVPELLECESGIDISVGTLSKA-AGCQGGFVACSTRWKSLIQSRGRSFIFSTALP 213
           G  G G  ELL     + I   TL KA  G  GG+        SL++ R R ++FS +LP
Sbjct: 237 GPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPEPLVSLLRQRSRPYLFSNSLP 296

Query: 214 VPVVASVQAALHV---------SRKERWRRSLVWRHVQYFASLTKLNITSPIISIVVGSE 366
             VV     AL +         S   + RR   +R     A  T      PI  +++G  
Sbjct: 297 PAVVGCASKALDLLMESNAIIQSMAAKTRR---FRSKMEAAGFTVSGADHPICPVMLGDA 353

Query: 367 EAALRAGRHMLRSGFHV 417
             + +    ML+ G  V
Sbjct: 354 RLSSQMADDMLKKGIFV 370
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>HEM1_DEBHA (Q6BX71) 5-aminolevulinate synthase, mitochondrial precursor (EC|
           2.3.1.37) (5-aminolevulinic acid synthase)
           (Delta-aminolevulinate synthase) (Delta-ALA synthetase)
          Length = 575

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 37/139 (26%), Positives = 62/139 (44%), Gaps = 7/139 (5%)
 Frame = +1

Query: 43  NGGGVPELLECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPV 222
           +G   P+     + +D+  GTL KA G  GG++          +S    FIF+T LP  +
Sbjct: 341 SGIASPQTQTVMNRVDMVTGTLGKAYGTVGGYITGKANLIDWFRSFAPGFIFTTTLPPSI 400

Query: 223 VASVQAALHVSRKERWRRSLVWRHVQYFA-SLTKLNI-----TSPIISIVVGSEEAALRA 384
           +A   A++   R     R     + +Y   +LT + I      S I+ ++VG+   A +A
Sbjct: 401 MAGSSASIRYQRSTLQDRIAQQTNTRYVKNNLTDIGIPVIPNPSHIVPVLVGNALDAKKA 460

Query: 385 GRHML-RSGFHVTPIRPPT 438
              +L +   +V  I  PT
Sbjct: 461 SDLLLDKYNIYVQAINFPT 479
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>BIOF_HELPY (O25320) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 373

 Score = 39.7 bits (91), Expect = 0.003
 Identities = 31/118 (26%), Positives = 50/118 (42%), Gaps = 2/118 (1%)
 Frame = +1

Query: 91  ISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVVASVQAALH--VSRKE 264
           I + T SKA    G  +    +    + +R +S I++TAL +   A   A L   + +K+
Sbjct: 218 IKLSTFSKALASYGACILAPLQTIEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIVQKQ 277

Query: 265 RWRRSLVWRHVQYFASLTKLNITSPIISIVVGSEEAALRAGRHMLRSGFHVTPIRPPT 438
             +  L  +H Q       +   +   ++   S  A L A   +   GF V  IRPPT
Sbjct: 278 ELKNELS-KHQQIIFETLGIRTLAGFFTLEFESNPALLNAHHFLKEKGFLVGAIRPPT 334
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>LCB2_HUMAN (O15270) Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain|
           base biosynthesis protein 2) (LCB 2)
           (Serine-palmitoyl-CoA transferase 2) (SPT 2)
          Length = 562

 Score = 38.9 bits (89), Expect = 0.006
 Identities = 36/152 (23%), Positives = 62/152 (40%), Gaps = 22/152 (14%)
 Frame = +1

Query: 37  GDNGGGVPELLECE-SGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALP 213
           G  G GV E    +   +D+ +GT +K+ G  GG++         +++   S +++T+L 
Sbjct: 353 GPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLS 412

Query: 214 VPVVASVQAALHVSRKERWRRSLVWRHVQYFASLTKL--------------NITSPIISI 351
            PVV  +  ++     +    SL    VQ  A  T+               N  SP++ +
Sbjct: 413 PPVVEQIITSMKCIMGQD-GTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPL 471

Query: 352 VVGSEEAALRAGRHMLRS-------GFHVTPI 426
           ++         GR ML+        GF  TPI
Sbjct: 472 MLYMPAKIGAFGREMLKRNIGVVVVGFPATPI 503
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>BIOF_HELPJ (Q9ZLN3) 8-amino-7-oxononanoate synthase (EC 2.3.1.47) (AONS)|
           (8-amino-7-ketopelargonate synthase)
           (7-keto-8-amino-pelargonic acid synthetase) (7-KAP
           synthetase) (L-alanine--pimelyl CoA ligase)
          Length = 373

 Score = 38.5 bits (88), Expect = 0.007
 Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 2/118 (1%)
 Frame = +1

Query: 91  ISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVVASVQAALH--VSRKE 264
           I + T SKA    G  V    +    + +R +S I++TAL +   A   A L   +++K+
Sbjct: 218 IKLSTFSKALASYGACVLAPLQVIEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIAQKQ 277

Query: 265 RWRRSLVWRHVQYFASLTKLNITSPIISIVVGSEEAALRAGRHMLRSGFHVTPIRPPT 438
             +  L  +H Q       +   +   ++   +  A L A   +   GF V  IRPPT
Sbjct: 278 ELKNELS-KHQQIIFETLGVRTPTGFFTLEFENNPALLNAQYFLKEKGFLVGAIRPPT 334
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>LCB2_CRIGR (O54694) Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain|
           base biosynthesis protein 2) (LCB 2)
           (Serine-palmitoyl-CoA transferase 2) (SPT 2)
          Length = 560

 Score = 37.0 bits (84), Expect = 0.022
 Identities = 34/152 (22%), Positives = 63/152 (41%), Gaps = 22/152 (14%)
 Frame = +1

Query: 37  GDNGGGVPELLECE-SGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALP 213
           G +G GV +    +   +D+ +GT +K+ G  GG++         +++   S +++T++ 
Sbjct: 351 GPSGRGVVDYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKALIDYLRTHSHSAVYATSMS 410

Query: 214 VPVVASVQAALHVSRKERWRRSLVWRHVQYFASLTKL--------------NITSPIISI 351
            PV+  +  ++     +    SL    VQ  A  TK               N  SP++ +
Sbjct: 411 PPVMEQIITSMKCIMGQD-GTSLGKECVQQLAENTKYFRRRLKEMGFIIYGNEDSPVVPL 469

Query: 352 VVGSEEAALRAGRHMLRS-------GFHVTPI 426
           ++         GR ML+        GF  TPI
Sbjct: 470 MLYMPAKIGAFGREMLKRNVGVVVVGFPATPI 501
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>LCB2_MOUSE (P97363) Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain|
           base biosynthesis protein 2) (LCB 2)
           (Serine-palmitoyl-CoA transferase 2) (SPT 2)
          Length = 560

 Score = 35.8 bits (81), Expect = 0.049
 Identities = 32/152 (21%), Positives = 63/152 (41%), Gaps = 22/152 (14%)
 Frame = +1

Query: 37  GDNGGGVPELLECE-SGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALP 213
           G +G GV +    +   +D+ +GT +K+ G  GG++         +++   S +++T++ 
Sbjct: 351 GPSGRGVVDYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSMS 410

Query: 214 VPVVASVQAALHVSRKERWRRSLVWRHVQYFASLTKL--------------NITSPIISI 351
            PV+  +  ++     +    SL    +Q  A  T+               N  SP++ +
Sbjct: 411 PPVMEQIITSMKCIMGQD-GTSLGKECIQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPL 469

Query: 352 VVGSEEAALRAGRHMLRS-------GFHVTPI 426
           ++         GR ML+        GF  TPI
Sbjct: 470 MLYMPAKIGAFGREMLKRNIGVVVVGFPATPI 501
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>LCB1_YEAST (P25045) Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain|
           base biosynthesis protein 1) (SPT 1) (SPT1)
          Length = 558

 Score = 35.4 bits (80), Expect = 0.063
 Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 2/74 (2%)
 Frame = +1

Query: 31  VCGDNGGGVPELLECE--SGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFST 204
           V G  G G+ E    +  + IDI+VG+++ A G  GGFV   +      +    ++ FS 
Sbjct: 327 VLGATGRGLSEHFNMDRATAIDITVGSMATALGSTGGFVLGDSVMCLHQRIGSNAYCFSA 386

Query: 205 ALPVPVVASVQAAL 246
            LP   V SV   L
Sbjct: 387 CLPAYTVTSVSKVL 400
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>LCB2_YEAST (P40970) Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain|
           base biosynthesis protein 2) (SPT 2)
          Length = 561

 Score = 35.0 bits (79), Expect = 0.083
 Identities = 20/71 (28%), Positives = 37/71 (52%), Gaps = 1/71 (1%)
 Frame = +1

Query: 37  GDNGGGVPELLECE-SGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALP 213
           G  G GV E+   +   +DI +GT +K+ G  GG++A        ++    +  +S ++P
Sbjct: 340 GPTGRGVCEIFGVDPKDVDILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYSESMP 399

Query: 214 VPVVASVQAAL 246
            PV+A   ++L
Sbjct: 400 APVLAQTISSL 410
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>LCB2_KLULA (P48241) Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain|
           base biosynthesis protein 2) (SPT 2)
          Length = 562

 Score = 33.9 bits (76), Expect = 0.18
 Identities = 26/76 (34%), Positives = 42/76 (55%), Gaps = 6/76 (7%)
 Frame = +1

Query: 37  GDNGGGVPEL--LECESGIDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFI----F 198
           G +G GV +   + C S IDI +GTL+K+ G  GG++A + +W   I  R R  +    +
Sbjct: 339 GPSGRGVCDFFGIPC-SDIDIMMGTLTKSFGAAGGYIA-ADKW---IIDRFRLDLTTPHY 393

Query: 199 STALPVPVVASVQAAL 246
               P PV+A + ++L
Sbjct: 394 GEPTPAPVLAQIASSL 409
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>LCB2_SCHPO (Q09925) Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain|
           base biosynthesis protein 2) (SPT 2)
          Length = 603

 Score = 33.5 bits (75), Expect = 0.24
 Identities = 14/70 (20%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
 Frame = +1

Query: 37  GDNGGGVPELLECESG-IDISVGTLSKAAGCQGGFVACSTRWKSLIQSRGRSFIFSTALP 213
           G  GGG+ +     +  +DI +GT +K+ G  GG+++ +    + ++     ++++ ++ 
Sbjct: 372 GPRGGGICDYFGISTDHVDILMGTFTKSFGAAGGYISATPNIINKLRVTNPGYVYAESMS 431

Query: 214 VPVVASVQAA 243
             V+A ++++
Sbjct: 432 PAVLAQIKSS 441
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>NDRG1_MOUSE (Q62433) Protein NDRG1 (N-myc downstream-regulated gene 1 protein)|
           (Protein Ndr1)
          Length = 394

 Score = 32.3 bits (72), Expect = 0.54
 Identities = 16/35 (45%), Positives = 20/35 (57%)
 Frame = +1

Query: 28  LVCGDNGGGVPELLECESGIDISVGTLSKAAGCQG 132
           LV GDN   V  ++EC S +D +  TL K A C G
Sbjct: 257 LVVGDNSPAVDAVVECNSKLDPTKTTLLKMADCGG 291
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>NDRG3_XENLA (Q6GQL1) Protein NDRG3|
          Length = 375

 Score = 32.0 bits (71), Expect = 0.70
 Identities = 16/35 (45%), Positives = 20/35 (57%)
 Frame = +1

Query: 28  LVCGDNGGGVPELLECESGIDISVGTLSKAAGCQG 132
           LV GDN   V  ++EC S +D +  TL K A C G
Sbjct: 258 LVVGDNSPAVDAVVECNSRLDPTRTTLLKMADCGG 292
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>NDRG3_MOUSE (Q9QYF9) Protein NDRG3 (Protein Ndr3)|
          Length = 375

 Score = 30.8 bits (68), Expect = 1.6
 Identities = 16/35 (45%), Positives = 19/35 (54%)
 Frame = +1

Query: 28  LVCGDNGGGVPELLECESGIDISVGTLSKAAGCQG 132
           LV GDN   V  ++EC S +D    TL K A C G
Sbjct: 258 LVVGDNSPAVEAVVECNSRLDPINTTLLKMADCGG 292
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>NDRG1_HUMAN (Q92597) Protein NDRG1 (N-myc downstream-regulated gene 1 protein)|
           (Differentiation-related gene 1 protein) (DRG-1)
           (Reducing agents and tunicamycin-responsive protein)
           (RTP) (Nickel-specific induction protein Cap43) (Rit42)
          Length = 394

 Score = 30.4 bits (67), Expect = 2.0
 Identities = 15/35 (42%), Positives = 20/35 (57%)
 Frame = +1

Query: 28  LVCGDNGGGVPELLECESGIDISVGTLSKAAGCQG 132
           LV GD+   V  ++EC S +D +  TL K A C G
Sbjct: 257 LVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGG 291
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>NDRG3_XENTR (Q6DFS4) Protein NDRG3|
          Length = 387

 Score = 30.0 bits (66), Expect = 2.7
 Identities = 15/35 (42%), Positives = 20/35 (57%)
 Frame = +1

Query: 28  LVCGDNGGGVPELLECESGIDISVGTLSKAAGCQG 132
           LV GD+   V  ++EC S +D +  TL K A C G
Sbjct: 257 LVVGDSSPAVDAVVECNSRLDPTRTTLLKMADCGG 291
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>NDR1B_XENLA (Q7ZWV3) Protein NDRG1-B (xNDRG1-B)|
          Length = 396

 Score = 30.0 bits (66), Expect = 2.7
 Identities = 16/37 (43%), Positives = 22/37 (59%)
 Frame = +1

Query: 28  LVCGDNGGGVPELLECESGIDISVGTLSKAAGCQGGF 138
           LV GD+   V  ++EC S +D +  TL K + C GGF
Sbjct: 258 LVVGDSSPAVDAVVECNSKLDPTKTTLLKMSDC-GGF 293
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>NDR1A_XENLA (Q641F2) Protein NDRG1-A (xNDRG1-A)|
          Length = 396

 Score = 30.0 bits (66), Expect = 2.7
 Identities = 16/37 (43%), Positives = 22/37 (59%)
 Frame = +1

Query: 28  LVCGDNGGGVPELLECESGIDISVGTLSKAAGCQGGF 138
           LV GD+   V  ++EC S +D +  TL K + C GGF
Sbjct: 258 LVVGDSSPAVDAVVECNSKLDPTKTTLLKMSDC-GGF 293
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>LPXD_AGRT5 (Q8UFL5) UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase|
           (EC 2.3.1.-)
          Length = 355

 Score = 29.6 bits (65), Expect = 3.5
 Identities = 28/91 (30%), Positives = 40/91 (43%)
 Frame = +1

Query: 124 CQGGFVACSTRWKSLIQSRGRSFIFSTALPVPVVASVQAALHVSRKERWRRSLVWRHVQY 303
           C+ G V C    KSLI S   + I  T  P  + A V A LH S     R SLV R    
Sbjct: 65  CEAGAVICDAALKSLIPSHIPALISKT--PHTLFAQVGALLHPS---AMRPSLVARMEAE 119

Query: 304 FASLTKLNITSPIISIVVGSEEAALRAGRHM 396
            +    ++ ++ +   V+    A + AG H+
Sbjct: 120 ISPAAYVDPSAKLEPGVIVEPMAVIGAGVHI 150
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>NDRG3_HUMAN (Q9UGV2) Protein NDRG3|
          Length = 375

 Score = 28.9 bits (63), Expect = 5.9
 Identities = 15/35 (42%), Positives = 19/35 (54%)
 Frame = +1

Query: 28  LVCGDNGGGVPELLECESGIDISVGTLSKAAGCQG 132
           LV GDN   V  ++EC S ++    TL K A C G
Sbjct: 258 LVVGDNSPAVEAVVECNSRLNPINTTLLKMADCGG 292
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>NDRG1_XENTR (Q66IG4) Protein NDRG1|
          Length = 395

 Score = 28.9 bits (63), Expect = 5.9
 Identities = 15/37 (40%), Positives = 22/37 (59%)
 Frame = +1

Query: 28  LVCGDNGGGVPELLECESGIDISVGTLSKAAGCQGGF 138
           LV GD+   V  +++C S +D +  TL K + C GGF
Sbjct: 257 LVVGDSSPAVDAVVDCNSKLDPTKTTLLKMSDC-GGF 292
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>AROC_METAC (Q8TT87) Chorismate synthase (EC 4.2.3.5)|
           (5-enolpyruvylshikimate-3-phosphate phospholyase)
          Length = 365

 Score = 28.9 bits (63), Expect = 5.9
 Identities = 24/80 (30%), Positives = 33/80 (41%), Gaps = 1/80 (1%)
 Frame = +1

Query: 175 SRGRSFIFSTAL-PVPVVASVQAALHVSRKERWRRSLVWRHVQYFASLTKLNITSPIISI 351
           S G   I   A+ P P +  VQ  + ++ +E    S+  RH          + T P   +
Sbjct: 288 STGLDIICRAAVKPTPSIGKVQQTVDLTTRENTEISIRGRH----------DPTIPPRMV 337

Query: 352 VVGSEEAALRAGRHMLRSGF 411
            V     AL    HMLRSGF
Sbjct: 338 PVAEAMVALVLSDHMLRSGF 357
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>ATP7B_HUMAN (P35670) Copper-transporting ATPase 2 (EC 3.6.3.4) (Copper pump 2)|
            (Wilson disease-associated protein)
          Length = 1465

 Score = 28.5 bits (62), Expect = 7.7
 Identities = 14/43 (32%), Positives = 25/43 (58%), Gaps = 3/43 (6%)
 Frame = +1

Query: 217  PVVASVQAALHVSRKERWR---RSLVWRHVQYFASLTKLNITS 336
            P+ AS Q ++H+   +RWR   R+  W  V Y + ++  ++TS
Sbjct: 1394 PLTAS-QVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTS 1435
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>BCSA_PSEFL (P58931) Cellulose synthase catalytic subunit [UDP-forming] (EC|
           2.4.1.12)
          Length = 739

 Score = 28.5 bits (62), Expect = 7.7
 Identities = 16/51 (31%), Positives = 25/51 (49%)
 Frame = -1

Query: 398 SICLPALSAASSLPTTMEIMGLVILSLVKDAKYCTCLQTNDLRHLSFLETW 246
           ++C  A+     +P  + I+ LV+LSLV   +Y     T+ L      ETW
Sbjct: 67  AVCFLAVLVLRKIPGRLAILALVVLSLVASLRYMFWRLTSTLG----FETW 113


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,416,381
Number of Sequences: 219361
Number of extensions: 973903
Number of successful extensions: 2882
Number of sequences better than 10.0: 82
Number of HSP's better than 10.0 without gapping: 2806
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2863
length of database: 80,573,946
effective HSP length: 101
effective length of database: 58,418,485
effective search space used: 2628831825
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
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