ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
menu 
| Clone Name | basd23n23 |
|---|---|
| Clone Library Name | barley_pub |
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 126 bits (317), Expect = 5e-29 Identities = 62/152 (40%), Positives = 101/152 (66%), Gaps = 4/152 (2%) Frame = +3 Query: 186 FTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASE--RQQKEFGKEM 359 F+ EELE+ATG F E + +GKG+ V+KG +D +VA+K+ AS+ + KEF E+ Sbjct: 493 FSYEELEQATGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKRAIKASDVKKSSKEFHNEL 552 Query: 360 LIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDG--PRIPFTARLNIA 533 ++S++NH +++ L G C + +LVY+++ +G+LY+ +HG+ R+ + R+ IA Sbjct: 553 DLLSRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLHGKDPNLKKRLNWARRVTIA 612 Query: 534 HQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 Q A + YLH +A PP+IH D+K+SNIL+DE Sbjct: 613 VQAARGIEYLHGYACPPVIHRDIKSSNILIDE 644
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 111 bits (277), Expect = 2e-24 Identities = 63/158 (39%), Positives = 93/158 (58%), Gaps = 11/158 (6%) Frame = +3 Query: 186 FTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEML- 362 F++ E+ + DE+NVIG G++G VYK + E+VA+KK + + E+ + L Sbjct: 674 FSEHEIADC---LDEKNVIGFGSSGKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDSLN 730 Query: 363 ---------IVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHG-RRDGPRIPF 512 + I H+ IV+L+ CC + +LVY+Y+PNG+L ++HG R+ G + + Sbjct: 731 RDVFAAEVETLGTIRHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKGGVVLGW 790 Query: 513 TARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 RL IA AE LSYLH PPI+H DVK+SNILLD Sbjct: 791 PERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILLD 828
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 110 bits (274), Expect = 4e-24 Identities = 61/151 (40%), Positives = 87/151 (57%), Gaps = 1/151 (0%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEM 359 K + ++L ++T FD+ N+IG G G VYK T D + VAIKK + ++EF E+ Sbjct: 720 KELSYDDLLDSTNSFDQANIIGCGGFGMVYKATLPDGKKVAIKKLSGDCGQIEREFEAEV 779 Query: 360 LIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPR-IPFTARLNIAH 536 +S+ H +V L G C +L+Y Y+ NG+L +H R DGP + + RL IA Sbjct: 780 ETLSRAQHPNLVLLRGFCFYKNDRLLIYSYMENGSLDYWLHERNDGPALLKWKTRLRIAQ 839 Query: 537 QTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 A+ L YLH P I+H D+K+SNILLDE Sbjct: 840 GAAKGLLYLHEGCDPHILHRDIKSSNILLDE 870
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 106 bits (265), Expect = 5e-23 Identities = 60/156 (38%), Positives = 95/156 (60%), Gaps = 1/156 (0%) Frame = +3 Query: 165 QGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKE 344 + +S K FT E +E+AT ++ + +IG+G G+VY+GT D + VA+K S + +E Sbjct: 579 KSVSVKPFTLEYIEQATEQY--KTLIGEGGFGSVYRGTLDDGQEVAVKVRSSTSTQGTRE 636 Query: 345 FGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRI-PFTAR 521 F E+ ++S I H +V L G C E + +LVY ++ NG+L ++G +I + R Sbjct: 637 FDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEASKRKILDWPTR 696 Query: 522 LNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 L+IA A L+YLH++ +IH DVK+SNILLD+ Sbjct: 697 LSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQ 732
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 105 bits (261), Expect = 1e-22 Identities = 65/168 (38%), Positives = 98/168 (58%), Gaps = 2/168 (1%) Frame = +3 Query: 132 GLTLFDEMRSRQGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTT-KDNELVAIK 308 GL L D++ ++ + FT +EL EATG F +G+G G V+KGT K +++VAIK Sbjct: 76 GLNLNDQVTGKKA---QTFTFQELAEATGNFRSDCFLGEGGFGKVFKGTIEKLDQVVAIK 132 Query: 309 KCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGR 488 + + +EF E+L +S +H +VKL G C E + +LVY+Y+P G+L +H Sbjct: 133 QLDRNGVQGIREFVVEVLTLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHVL 192 Query: 489 RDGPR-IPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 G + + + R+ IA A L YLH +PP+I+ D+K SNILL E Sbjct: 193 PSGKKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGE 240
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 104 bits (260), Expect = 2e-22 Identities = 61/148 (41%), Positives = 86/148 (58%), Gaps = 1/148 (0%) Frame = +3 Query: 189 TQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIV 368 T +L EAT F +++G G G VYK KD +VAIKK S + +EF EM + Sbjct: 877 TFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETI 936 Query: 369 SQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGR-RDGPRIPFTARLNIAHQTA 545 +I HR +V L G C E +LVY+Y+ G+L ++H R + G ++ + AR IA A Sbjct: 937 GKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKTGIKLNWPARRKIAIGAA 996 Query: 546 EALSYLHSWASPPIIHGDVKTSNILLDE 629 L++LH P IIH D+K+SN+LLDE Sbjct: 997 RGLAFLHHNCIPHIIHRDMKSSNVLLDE 1024
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 104 bits (260), Expect = 2e-22 Identities = 61/148 (41%), Positives = 86/148 (58%), Gaps = 1/148 (0%) Frame = +3 Query: 189 TQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIV 368 T +L EAT F +++G G G VYK KD +VAIKK S + +EF EM + Sbjct: 877 TFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETI 936 Query: 369 SQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRD-GPRIPFTARLNIAHQTA 545 +I HR +V L G C E +LVY+Y+ G+L ++H R+ G ++ + AR IA A Sbjct: 937 GKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKIGIKLNWPARRKIAIGAA 996 Query: 546 EALSYLHSWASPPIIHGDVKTSNILLDE 629 L++LH P IIH D+K+SN+LLDE Sbjct: 997 RGLAFLHHNCIPHIIHRDMKSSNVLLDE 1024
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 104 bits (259), Expect = 2e-22 Identities = 61/154 (39%), Positives = 88/154 (57%), Gaps = 4/154 (2%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQK---EFG 350 K F+ EL+ A+ F +N++G+G G VYKG D LVA+K RL ER Q +F Sbjct: 275 KRFSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTLVAVK--RLKEERTQGGELQFQ 332 Query: 351 KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDG-PRIPFTARLN 527 E+ ++S HR +++L G C+ +LVY Y+ NG++ + R + P + + R Sbjct: 333 TEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQR 392 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 IA +A L+YLH P IIH DVK +NILLDE Sbjct: 393 IALGSARGLAYLHDHCDPKIIHRDVKAANILLDE 426
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 103 bits (258), Expect = 3e-22 Identities = 60/165 (36%), Positives = 98/165 (59%), Gaps = 5/165 (3%) Frame = +3 Query: 147 DEMRSRQGLSFKLFTQEEL----EEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKC 314 ++ ++++ L++KL ++L E+ E N+IGKG G VY+G+ +N VAIK+ Sbjct: 663 NKKKNQKSLAWKLTAFQKLDFKSEDVLECLKEENIIGKGGAGIVYRGSMPNNVDVAIKRL 722 Query: 315 -RLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRR 491 + R F E+ + +I HR+IV+L G + +L+Y+Y+PNG+L L+HG + Sbjct: 723 VGRGTGRSDHGFTAEIQTLGRIRHRHIVRLLGYVANKDTNLLLYEYMPNGSLGELLHGSK 782 Query: 492 DGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 G + + R +A + A+ L YLH SP I+H DVK++NILLD Sbjct: 783 GG-HLQWETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNNILLD 826
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 103 bits (257), Expect = 4e-22 Identities = 60/155 (38%), Positives = 93/155 (60%), Gaps = 1/155 (0%) Frame = +3 Query: 165 QGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKE 344 + +S K FT E +E AT ++ + +IG+G G+VY+GT D + VA+K S + +E Sbjct: 578 KSVSVKPFTLEYIELATEKY--KTLIGEGGFGSVYRGTLDDGQEVAVKVRSATSTQGTRE 635 Query: 345 FGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRI-PFTAR 521 F E+ ++S I H +V L G C E + +LVY ++ NG+L ++G +I + R Sbjct: 636 FDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEPAKRKILDWPTR 695 Query: 522 LNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 L+IA A L+YLH++ +IH DVK+SNILLD Sbjct: 696 LSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLD 730
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 102 bits (254), Expect = 9e-22 Identities = 60/166 (36%), Positives = 90/166 (54%), Gaps = 1/166 (0%) Frame = +3 Query: 135 LTLFDEMRSRQGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKC 314 + LF S LS +++ ++T F++ N+IG G G VYK T D VAIK+ Sbjct: 719 VVLFHNKDSNNELSL-----DDILKSTSSFNQANIIGCGGFGLVYKATLPDGTKVAIKRL 773 Query: 315 RLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRD 494 + + +EF E+ +S+ H +V L G C +L+Y Y+ NG+L +H + D Sbjct: 774 SGDTGQMDREFQAEVETLSRAQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLHEKVD 833 Query: 495 G-PRIPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 G P + + RL IA AE L+YLH P I+H D+K+SNILL + Sbjct: 834 GPPSLDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLSD 879
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 100 bits (250), Expect = 3e-21 Identities = 58/148 (39%), Positives = 87/148 (58%), Gaps = 1/148 (0%) Frame = +3 Query: 189 TQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIV 368 T +L +AT F ++IG G G VYK KD VAIKK S + +EF EM + Sbjct: 872 TFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETI 931 Query: 369 SQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHG-RRDGPRIPFTARLNIAHQTA 545 +I HR +V L G C + +LVY+++ G+L ++H ++ G ++ ++ R IA +A Sbjct: 932 GKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSA 991 Query: 546 EALSYLHSWASPPIIHGDVKTSNILLDE 629 L++LH SP IIH D+K+SN+LLDE Sbjct: 992 RGLAFLHHNCSPHIIHRDMKSSNVLLDE 1019
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 100 bits (249), Expect = 4e-21 Identities = 58/153 (37%), Positives = 91/153 (59%), Gaps = 1/153 (0%) Frame = +3 Query: 174 SFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKE-FG 350 +F+ ++ EL +AT +F +G+G +GTVYKG +D+ VA+KK L + RQ KE F Sbjct: 520 NFRRYSYRELVKATRKFKVE--LGRGESGTVYKGVLEDDRHVAVKK--LENVRQGKEVFQ 575 Query: 351 KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNI 530 E+ ++ +INH +V+++G C E +LV +Y+ NG+L ++ + + R NI Sbjct: 576 AELSVIGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANILFSEGGNILLDWEGRFNI 635 Query: 531 AHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 A A+ L+YLH +IH DVK NILLD+ Sbjct: 636 ALGVAKGLAYLHHECLEWVIHCDVKPENILLDQ 668
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 100 bits (248), Expect = 5e-21 Identities = 52/153 (33%), Positives = 86/153 (56%) Frame = +3 Query: 171 LSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFG 350 L L E + +AT F N +G+G G VYKG D + +A+K+ S + EF Sbjct: 511 LELPLIEMETVVKATENFSSCNKLGQGGFGIVYKGRLLDGKEIAVKRLSKTSVQGTDEFM 570 Query: 351 KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNI 530 E+ +++++ H +V++ GCC+E + ML+Y+Y+ N +L + G+ ++ + R +I Sbjct: 571 NEVTLIARLQHINLVQVLGCCIEGDEKMLIYEYLENLSLDSYLFGKTRRSKLNWNERFDI 630 Query: 531 AHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 + A L YLH + IIH D+K SNILLD+ Sbjct: 631 TNGVARGLLYLHQDSRFRIIHRDLKVSNILLDK 663
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 99.8 bits (247), Expect = 6e-21 Identities = 59/147 (40%), Positives = 84/147 (57%), Gaps = 3/147 (2%) Frame = +3 Query: 198 ELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQI 377 +L EAT F ++IG G G V+K T KD VAIKK S + +EF EM + +I Sbjct: 830 QLIEATNGFSAASMIGHGGFGEVFKATLKDGSSVAIKKLIRLSCQGDREFMAEMETLGKI 889 Query: 378 NHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPR---IPFTARLNIAHQTAE 548 HR +V L G C E +LVY+++ G+L ++HG R G + + + R IA A+ Sbjct: 890 KHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAKGAAK 949 Query: 549 ALSYLHSWASPPIIHGDVKTSNILLDE 629 L +LH P IIH D+K+SN+LLD+ Sbjct: 950 GLCFLHHNCIPHIIHRDMKSSNVLLDQ 976
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 99.0 bits (245), Expect = 1e-20 Identities = 58/150 (38%), Positives = 83/150 (55%), Gaps = 3/150 (2%) Frame = +3 Query: 189 TQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIV 368 T L EAT F ++G G G VYK +D +VAIKK + + +EF EM + Sbjct: 848 TFAHLLEATNGFSAETMVGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGDREFMAEMETI 907 Query: 369 SQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIH---GRRDGPRIPFTARLNIAHQ 539 +I HR +V L G C E +LVY+Y+ G+L ++H ++ G + + AR IA Sbjct: 908 GKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIG 967 Query: 540 TAEALSYLHSWASPPIIHGDVKTSNILLDE 629 A L++LH P IIH D+K+SN+LLDE Sbjct: 968 AARGLAFLHHSCIPHIIHRDMKSSNVLLDE 997
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 97.8 bits (242), Expect = 2e-20 Identities = 61/167 (36%), Positives = 88/167 (52%), Gaps = 10/167 (5%) Frame = +3 Query: 156 RSRQGLSFKLFTQEE---------LEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIK 308 RSR+ LS + E+ + EAT F ++N+IG G GTVYK + VA+K Sbjct: 886 RSREPLSINIAMFEQPLLKVRLGDIVEATDHFSKKNIIGDGGFGTVYKACLPGEKTVAVK 945 Query: 309 KCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGR 488 K A + +EF EM + ++ H +V L G C E +LVY+Y+ NG+L + + Sbjct: 946 KLSEAKTQGNREFMAEMETLGKVKHPNLVSLLGYCSFSEEKLLVYEYMVNGSLDHWLRNQ 1005 Query: 489 RDGPRI-PFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 + ++ RL IA A L++LH P IIH D+K SNILLD Sbjct: 1006 TGMLEVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLD 1052
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 97.4 bits (241), Expect = 3e-20 Identities = 58/149 (38%), Positives = 84/149 (56%), Gaps = 2/149 (1%) Frame = +3 Query: 189 TQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIV 368 T L EAT F ++IG G G VYK D +VAIKK + + +EF EM + Sbjct: 847 TFAHLLEATNGFSADSMIGSGGFGDVYKAKLADGSVVAIKKLIQVTGQGDREFMAEMETI 906 Query: 369 SQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIH--GRRDGPRIPFTARLNIAHQT 542 +I HR +V L G C E +LVY+Y+ G+L ++H ++ G + ++AR IA Sbjct: 907 GKIKHRNLVPLLGYCKIGEERLLVYEYMKYGSLETVLHEKTKKGGIFLDWSARKKIAIGA 966 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILLDE 629 A L++LH P IIH D+K+SN+LLD+ Sbjct: 967 ARGLAFLHHSCIPHIIHRDMKSSNVLLDQ 995
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 95.9 bits (237), Expect = 9e-20 Identities = 50/141 (35%), Positives = 81/141 (57%), Gaps = 1/141 (0%) Frame = +3 Query: 207 EATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQK-EFGKEMLIVSQINH 383 EAT +++ VIGKGA+GT+YK T +++ A+KK + +E+ + ++ H Sbjct: 811 EATENLNDKYVIGKGAHGTIYKATLSPDKVYAVKKLVFTGIKNGSVSMVREIETIGKVRH 870 Query: 384 RYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYL 563 R ++KL L E +++Y Y+ NG+L+ ++H + ++ R NIA TA L+YL Sbjct: 871 RNLIKLEEFWLRKEYGLILYTYMENGSLHDILHETNPPKPLDWSTRHNIAVGTAHGLAYL 930 Query: 564 HSWASPPIIHGDVKTSNILLD 626 H P I+H D+K NILLD Sbjct: 931 HFDCDPAIVHRDIKPMNILLD 951
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 94.0 bits (232), Expect = 3e-19 Identities = 53/153 (34%), Positives = 83/153 (54%), Gaps = 4/153 (2%) Frame = +3 Query: 183 LFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCR--LASERQQKEFGKE 356 L + + L T F N++G G G VYKG D +A+K+ + + + EF E Sbjct: 575 LISIQVLRSVTNNFSSDNILGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKGFAEFKSE 634 Query: 357 MLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYR-LIHGRRDGPR-IPFTARLNI 530 + +++++ HR++V L G CL+ +LVY+Y+P GTL R L +G + + + RL + Sbjct: 635 IAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLLWKQRLTL 694 Query: 531 AHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 A A + YLH A IH D+K SNILL + Sbjct: 695 ALDVARGVEYLHGLAHQSFIHRDLKPSNILLGD 727
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 90.9 bits (224), Expect = 3e-18 Identities = 54/150 (36%), Positives = 85/150 (56%), Gaps = 2/150 (1%) Frame = +3 Query: 186 FTQEELEEATGRFDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEFGKEML 362 F EL AT F +G+G G VYKG ++VA+K+ + +EF E+L Sbjct: 74 FAFRELAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGNREFLVEVL 133 Query: 363 IVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRR-DGPRIPFTARLNIAHQ 539 ++S ++H +V L G C + + +LVY+++P G+L +H D + + R+ IA Sbjct: 134 MLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIAAG 193 Query: 540 TAEALSYLHSWASPPIIHGDVKTSNILLDE 629 A+ L +LH A+PP+I+ D K+SNILLDE Sbjct: 194 AAKGLEFLHDKANPPVIYRDFKSSNILLDE 223
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 89.7 bits (221), Expect = 6e-18 Identities = 54/150 (36%), Positives = 82/150 (54%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEM 359 + F E+ T F+ VIGKG G VY G + E VA+K S + KEF E+ Sbjct: 562 RYFKYSEVVNITNNFER--VIGKGGFGKVYHGVI-NGEQVAVKVLSEESAQGYKEFRAEV 618 Query: 360 LIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQ 539 ++ +++H + L G C E+ +L+Y+Y+ N L + G+R + + RL I+ Sbjct: 619 DLLMRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYLAGKRSFI-LSWEERLKISLD 677 Query: 540 TAEALSYLHSWASPPIIHGDVKTSNILLDE 629 A+ L YLH+ PPI+H DVK +NILL+E Sbjct: 678 AAQGLEYLHNGCKPPIVHRDVKPTNILLNE 707
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 86.7 bits (213), Expect = 5e-17 Identities = 58/165 (35%), Positives = 90/165 (54%), Gaps = 11/165 (6%) Frame = +3 Query: 165 QGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNEL----------VAIKKC 314 Q + K FT EL+ AT F +V+G+G G+V+KG + L +A+KK Sbjct: 50 QSPNLKSFTFAELKAATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPGTGVVIAVKKL 109 Query: 315 RLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRD 494 + +E+ E+ + Q +H +VKL G CLE E +LVY+++P G+L + R Sbjct: 110 NQDGWQGHQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGS 169 Query: 495 -GPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 + +T RL +A A+ L++LH+ A +I+ D KTSNILLD Sbjct: 170 YFQPLSWTLRLKVALGAAKGLAFLHN-AETSVIYRDFKTSNILLD 213
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 86.3 bits (212), Expect = 7e-17 Identities = 59/167 (35%), Positives = 91/167 (54%), Gaps = 13/167 (7%) Frame = +3 Query: 165 QGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNEL----------VAIKKC 314 Q + K F+ EL+ AT F +V+G+G G V+KG + L +A+KK Sbjct: 49 QSPNLKSFSFAELKSATRNFRPDSVLGEGGFGCVFKGWIDEKSLTASRPGTGLVIAVKKL 108 Query: 315 RLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRD 494 + +E+ E+ + Q +HR++VKL G CLE E +LVY+++P G+L H R Sbjct: 109 NQDGWQGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLEN--HLFRR 166 Query: 495 G---PRIPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 G + + RL +A A+ L++LHS + +I+ D KTSNILLD Sbjct: 167 GLYFQPLSWKLRLKVALGAAKGLAFLHS-SETRVIYRDFKTSNILLD 212
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 82.0 bits (201), Expect = 1e-15 Identities = 53/165 (32%), Positives = 89/165 (53%), Gaps = 11/165 (6%) Frame = +3 Query: 165 QGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNEL----------VAIKKC 314 Q + K F+ EL+ AT F +V+G+G G V+KG ++ L +A+K+ Sbjct: 49 QNANLKNFSLSELKSATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRL 108 Query: 315 RLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRD 494 + +E+ E+ + Q++H +VKL G CLE E +LVY+++ G+L + R Sbjct: 109 NQEGFQGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFRRGT 168 Query: 495 GPR-IPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 + + + R+ +A A L++LH+ A P +I+ D K SNILLD Sbjct: 169 FYQPLSWNTRVRMALGAARGLAFLHN-AQPQVIYRDFKASNILLD 212
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 82.0 bits (201), Expect = 1e-15 Identities = 52/161 (32%), Positives = 87/161 (54%), Gaps = 10/161 (6%) Frame = +3 Query: 177 FKLFTQEELEEATGRFDER------NVIGKGANGTVYKGTTKDNELVAIKKC----RLAS 326 F F+ EL+ T FDE+ N +G+G G VYKG +N +VA+KK +++ Sbjct: 165 FHSFSFHELKSITNNFDEQPASAGGNRMGEGGFGVVYKGCV-NNTIVAVKKLGAMVEIST 223 Query: 327 ERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRI 506 E +++F +E+ +++ H +V+L G + + LVY Y+PNG+L + P + Sbjct: 224 EELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTPPL 283 Query: 507 PFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 + R +A TA + +LH IH D+K++NILLD+ Sbjct: 284 SWHTRCKVAQGTANGIRFLH---ENHHIHRDIKSANILLDK 321
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 81.6 bits (200), Expect = 2e-15 Identities = 54/161 (33%), Positives = 86/161 (53%), Gaps = 10/161 (6%) Frame = +3 Query: 177 FKLFTQEELEEATGRFDER------NVIGKGANGTVYKGTTKDNELVAIKKCR----LAS 326 F F+ EL+ T FDER N +G+G G VYKG +N VA+KK + + Sbjct: 165 FHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYV-NNTTVAVKKLAAMVDITT 223 Query: 327 ERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRI 506 E +++F +E+ ++++ H +V+L G + + LVY Y+PNG+L + P + Sbjct: 224 EELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPL 283 Query: 507 PFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 + R IA A +++LH IH D+K++NILLDE Sbjct: 284 SWHMRCKIAQGAANGINFLH---ENHHIHRDIKSANILLDE 321
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 81.3 bits (199), Expect = 2e-15 Identities = 51/149 (34%), Positives = 82/149 (55%), Gaps = 5/149 (3%) Frame = +3 Query: 198 ELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQ----QKEFGKEMLI 365 E+ T F E IG+G G VY+ + N + A+K+ + ++ + ++ F E+ Sbjct: 204 EISRGTHNFSEELKIGEGGFGCVYRAVMR-NTVYAVKRLKENADLEWTAVKQSFLTEVEQ 262 Query: 366 VSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDG-PRIPFTARLNIAHQT 542 +S+ H IV G C + LVY ++PNG+L +H + P + + RL+I T Sbjct: 263 LSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGT 322 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILLDE 629 A A+ +LH SP +IHGD+K+SN+LLDE Sbjct: 323 ARAIQFLHQ-DSPSLIHGDIKSSNVLLDE 350
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 80.5 bits (197), Expect = 4e-15 Identities = 45/133 (33%), Positives = 78/133 (58%), Gaps = 4/133 (3%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNEL-VAIKKCRLAS---ERQQKEFGKEMLIVSQINHRYIVKLYG 407 + +GA+GTV D + VA+K + + + ++K+ +E I+ + YI+ + G Sbjct: 24 LSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILG 83 Query: 408 CCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPI 587 C E E +V +Y+PNG+L L+H + + P + + R I H+ A ++YLH+ +PP+ Sbjct: 84 ICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHN-MTPPL 142 Query: 588 IHGDVKTSNILLD 626 +H D+KT NILLD Sbjct: 143 LHHDLKTQNILLD 155
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 79.7 bits (195), Expect = 6e-15 Identities = 51/149 (34%), Positives = 82/149 (55%), Gaps = 5/149 (3%) Frame = +3 Query: 198 ELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQ----QKEFGKEMLI 365 E+ + T F E IG+G G VY+ + N A+K+ + ++ + ++ F E+ Sbjct: 204 EISQGTCNFSEELRIGEGGFGCVYRAVMR-NTTYAVKRLKEEADLEWTMVKQSFLTEVEQ 262 Query: 366 VSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDG-PRIPFTARLNIAHQT 542 +S+ H IV G C E + LVY ++PNG+L +H + + + RL+I T Sbjct: 263 LSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGT 322 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILLDE 629 A A+ +LH SP +IHGD+K+SN+LLDE Sbjct: 323 ARAIQFLHQ-DSPSLIHGDIKSSNVLLDE 350
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 79.3 bits (194), Expect = 8e-15 Identities = 45/133 (33%), Positives = 77/133 (57%), Gaps = 4/133 (3%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNEL-VAIKKCRLAS---ERQQKEFGKEMLIVSQINHRYIVKLYG 407 + +GA+GTV D + VA+K + + + ++ + +E I+ + YI+ + G Sbjct: 24 LSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSERNDILREAEILHKARFSYILPILG 83 Query: 408 CCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPI 587 C E E +V +Y+PNG+L L+H + + P I + R I H+ A ++YLH+ +PP+ Sbjct: 84 ICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRILHEIALGVNYLHN-MNPPL 142 Query: 588 IHGDVKTSNILLD 626 +H D+KT NILLD Sbjct: 143 LHHDLKTQNILLD 155
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 79.0 bits (193), Expect = 1e-14 Identities = 53/153 (34%), Positives = 82/153 (53%) Frame = +3 Query: 165 QGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKE 344 Q L+F+ +E+E V+G+GA G V K + + VAIK+ + SE ++K Sbjct: 24 QVLNFEEIDYKEIEV-------EEVVGRGAFGVVCKAKWRAKD-VAIKQ--IESESERKA 73 Query: 345 FGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARL 524 F E+ +S++NH IVKLYG CL LV +Y G+LY ++HG P + Sbjct: 74 FIVELRQLSRVNHPNIVKLYGACLNPVC--LVMEYAEGGSLYNVLHGAEPLPYYTAAHAM 131 Query: 525 NIAHQTAEALSYLHSWASPPIIHGDVKTSNILL 623 + Q ++ ++YLHS +IH D+K N+LL Sbjct: 132 SWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLL 164
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 79.0 bits (193), Expect = 1e-14 Identities = 53/153 (34%), Positives = 82/153 (53%) Frame = +3 Query: 165 QGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKE 344 Q L+F+ +E+E V+G+GA G V K + + VAIK+ + SE ++K Sbjct: 24 QVLNFEEIDYKEIEV-------EEVVGRGAFGVVCKAKWRAKD-VAIKQ--IESESERKA 73 Query: 345 FGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARL 524 F E+ +S++NH IVKLYG CL LV +Y G+LY ++HG P + Sbjct: 74 FIVELRQLSRVNHPNIVKLYGACLNPVC--LVMEYAEGGSLYNVLHGAEPLPYYTAAHAM 131 Query: 525 NIAHQTAEALSYLHSWASPPIIHGDVKTSNILL 623 + Q ++ ++YLHS +IH D+K N+LL Sbjct: 132 SWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLL 164
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 79.0 bits (193), Expect = 1e-14 Identities = 67/202 (33%), Positives = 101/202 (50%), Gaps = 4/202 (1%) Frame = +3 Query: 36 CDRTDSPASCAYMIYAKRRLAKIKREYFEQHGGLTLFDEMRSRQGLSFKLFTQEELEEAT 215 C+ P + L KIK E+ L L E+ SR L E+E Sbjct: 412 CNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADVLLLRAELPSRFHLQLS-----EIE--- 463 Query: 216 GRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRL---ASERQQKEFGKEMLIVSQINHR 386 F E +IG G+ G VYKG + N++VAIK+ R S+ F +E+ I+ Q+NH Sbjct: 464 --FHE--IIGSGSFGKVYKGRCR-NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHP 518 Query: 387 YIVKLYGCCLEVEVPM-LVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYL 563 +V+ G CL+ +V +YI G+L+ L+H ++ + ++L IA A+ + YL Sbjct: 519 CVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQK--RILDLQSKLIIAVDVAKGMEYL 576 Query: 564 HSWASPPIIHGDVKTSNILLDE 629 HS + PIIH D+ + NILL E Sbjct: 577 HS-LTQPIIHRDLNSHNILLYE 597
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 79.0 bits (193), Expect = 1e-14 Identities = 67/202 (33%), Positives = 101/202 (50%), Gaps = 4/202 (1%) Frame = +3 Query: 36 CDRTDSPASCAYMIYAKRRLAKIKREYFEQHGGLTLFDEMRSRQGLSFKLFTQEELEEAT 215 C+ P + L KIK E+ L L E+ SR L E+E Sbjct: 411 CNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADVLLLRAELPSRFHLQLS-----EIE--- 462 Query: 216 GRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRL---ASERQQKEFGKEMLIVSQINHR 386 F E +IG G+ G VYKG + N++VAIK+ R S+ F +E+ I+ Q+NH Sbjct: 463 --FHE--IIGSGSFGKVYKGRCR-NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHP 517 Query: 387 YIVKLYGCCLEVEVPM-LVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYL 563 +V+ G CL+ +V +YI G+L+ L+H ++ + ++L IA A+ + YL Sbjct: 518 CVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQK--RILDLQSKLIIAVDVAKGMEYL 575 Query: 564 HSWASPPIIHGDVKTSNILLDE 629 HS + PIIH D+ + NILL E Sbjct: 576 HS-LTQPIIHRDLNSHNILLYE 596
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 77.4 bits (189), Expect = 3e-14 Identities = 52/161 (32%), Positives = 83/161 (51%), Gaps = 10/161 (6%) Frame = +3 Query: 174 SFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNEL----------VAIKKCRLA 323 + K++ +L+ AT F +++G+G G VY+G L VAIK+ Sbjct: 70 NLKVYNFLDLKTATKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIKRLNSE 129 Query: 324 SERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPR 503 S + E+ E+ + ++HR +VKL G C E + +LVY+++P G+L + R D Sbjct: 130 SVQGFAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRRND--P 187 Query: 504 IPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 P+ R+ I A L++LHS +I+ D K SNILLD Sbjct: 188 FPWDLRIKIVIGAARGLAFLHS-LQREVIYRDFKASNILLD 227
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 74.7 bits (182), Expect = 2e-13 Identities = 44/131 (33%), Positives = 73/131 (55%) Frame = +3 Query: 231 RNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGC 410 R +G G+ G V K +D +LVA+K+ ++E QK+ KE+ +S++ H I+ L+G Sbjct: 22 REKVGHGSYGVVCKAVWRD-KLVAVKEFFASAE--QKDIEKEVKQLSRVKHPNIIALHGI 78 Query: 411 CLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPII 590 + L+ ++ G+L+ +HG+ P ++ A Q AE L+YLH+ P+I Sbjct: 79 SSYQQATYLIMEFAEGGSLHNFLHGKVK-PAYSLAHAMSWARQCAEGLAYLHAMTPKPLI 137 Query: 591 HGDVKTSNILL 623 H DVK N+LL Sbjct: 138 HRDVKPLNLLL 148
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 74.7 bits (182), Expect = 2e-13 Identities = 49/153 (32%), Positives = 79/153 (51%), Gaps = 9/153 (5%) Frame = +3 Query: 198 ELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASER------QQKEFGKEM 359 ELE AT + N +G+G G VY+G K + VAIK S + ++ E+ Sbjct: 205 ELENATDGWSPDNRLGQGGFGDVYRGKWKQLD-VAIKVMNYRSPNIDQKMVELQQSYNEL 263 Query: 360 LIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDG---PRIPFTARLNI 530 ++ I H I+ LYG ++ P LVY+ + G+L + + P + + R +I Sbjct: 264 KYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSI 323 Query: 531 AHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 + TA + +LH+ P+IHGD+K +NILLD+ Sbjct: 324 SLGTARGIYFLHTARGTPLIHGDIKPANILLDQ 356
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 73.6 bits (179), Expect = 5e-13 Identities = 48/135 (35%), Positives = 79/135 (58%), Gaps = 4/135 (2%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNELVAIKKCRL---ASERQQKEFGKEMLIVSQINHRYIVKLYG 407 +IG G+ G VYKG + N++VAIK+ R S+ F +E+ I+ Q+NH +++ G Sbjct: 569 IIGSGSFGKVYKGRCR-NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVG 627 Query: 408 CCL-EVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPP 584 CL + +V +YI G+L+ L+H ++ + ++L IA A+ + YLH+ + P Sbjct: 628 ACLNDPSQFAIVTQYISGGSLFSLLHEQK--RILDLQSKLIIAVDVAKGMEYLHN-LTQP 684 Query: 585 IIHGDVKTSNILLDE 629 IIH D+ + NILL E Sbjct: 685 IIHRDLNSHNILLYE 699
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 73.2 bits (178), Expect = 6e-13 Identities = 50/187 (26%), Positives = 97/187 (51%), Gaps = 8/187 (4%) Frame = +3 Query: 87 RRLAKIKREYFEQHGGLTLFD-EMRSRQGLSFKLFTQEELE-EATGRFDERNVIGKGANG 260 R K+K + GL ++D E + K+F++ L+ E + + ++GKGA G Sbjct: 1016 RETTKVKIQ--RHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYG 1073 Query: 261 TVYKGTTKDNELVAIKKC------RLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLEV 422 TVY G T +L+A+K+ +LA+E++ ++ +E+ ++ + H IV G CL+ Sbjct: 1074 TVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQE 1133 Query: 423 EVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGDV 602 + +++P G++ +I+ R GP +P Q + ++YLH ++H D+ Sbjct: 1134 NTVSIFMEFVPGGSISSIIN--RFGP-LPEMVFCKYTKQILQGVAYLHENC---VVHRDI 1187 Query: 603 KTSNILL 623 K +N++L Sbjct: 1188 KGNNVML 1194
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 71.2 bits (173), Expect = 2e-12 Identities = 48/135 (35%), Positives = 70/135 (51%), Gaps = 4/135 (2%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNELVAIKKCRLASERQQ----KEFGKEMLIVSQINHRYIVKLY 404 +IG G G VY+ + E VA+K RL E+ ++ +E + + H I+ L Sbjct: 103 IIGVGGFGKVYRALWRGEE-VAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALR 161 Query: 405 GCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPP 584 G CL LV +Y G L R++ GRR P + +N A Q A ++YLH+ A P Sbjct: 162 GACLNPPHLCLVMEYARGGALSRVLAGRRVPPHV----LVNWAVQVARGMNYLHNDAPVP 217 Query: 585 IIHGDVKTSNILLDE 629 IIH D+K+ NIL+ E Sbjct: 218 IIHRDLKSINILILE 232
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 70.5 bits (171), Expect = 4e-12 Identities = 48/141 (34%), Positives = 78/141 (55%), Gaps = 5/141 (3%) Frame = +3 Query: 222 FDERNV---IGKGANGTVYKGTTKDNELVAIKKC--RLASERQQKEFGKEMLIVSQINHR 386 +DE ++ IG G+ G V+ G K + VA+KK + SE Q EF EM +S++ H Sbjct: 1361 YDEISIGKQIGLGSYGIVFNGKWKGVD-VAVKKFVKQKLSETQLLEFRAEMAFLSELKHS 1419 Query: 387 YIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLH 566 IV G C++ +V +Y+ G L ++ + +I F +L + + A + YLH Sbjct: 1420 NIVTFIGACIKKPNICIVTEYMRMGNLRDVL--KNPDIKITFANKLKLLYGAAMGIDYLH 1477 Query: 567 SWASPPIIHGDVKTSNILLDE 629 S ++P I+H D+K +NIL+DE Sbjct: 1478 S-SNPMIVHRDIKPANILVDE 1497 Score = 62.0 bits (149), Expect = 1e-09 Identities = 37/130 (28%), Positives = 70/130 (53%), Gaps = 1/130 (0%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNEL-VAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCL 416 +G G G VYK K E+ V + + S+ ++ F +E+ I++ + H +V Sbjct: 792 LGTGGYGEVYKSIWKGTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAAST 851 Query: 417 EVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHG 596 + +V +++ G+LY L+ G P IP+ ++ +A+Q ++ + +LH S I+H Sbjct: 852 KSPNMCIVMEFMSLGSLYDLL-GNELIPEIPYALKIKMAYQASKGMHFLH---SSGIVHR 907 Query: 597 DVKTSNILLD 626 D+K+ N+LLD Sbjct: 908 DLKSLNLLLD 917
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 69.3 bits (168), Expect = 9e-12 Identities = 48/133 (36%), Positives = 68/133 (51%), Gaps = 4/133 (3%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNELVAIKKCRLASERQ----QKEFGKEMLIVSQINHRYIVKLY 404 VIG G G VY+G+ + ELVA+K R + + +E + + + H I+ L Sbjct: 122 VIGIGGFGKVYRGSWR-GELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALK 180 Query: 405 GCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPP 584 CLE LV +Y G L R + GRR P + +N A Q A + YLH A P Sbjct: 181 AVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHV----LVNWAVQIARGMHYLHCEALVP 236 Query: 585 IIHGDVKTSNILL 623 +IH D+K++NILL Sbjct: 237 VIHRDLKSNNILL 249
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 69.3 bits (168), Expect = 9e-12 Identities = 41/132 (31%), Positives = 76/132 (57%), Gaps = 2/132 (1%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQK--EFGKEMLIVSQINHRYIVKLYGCC 413 IG G+ GTV++ ++ VA+K ++ EF +E+ I+ ++ H IV G Sbjct: 557 IGAGSFGTVHRAEWHGSD-VAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAV 615 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + +V +Y+ G+LYRL+H ++ RL++A+ A+ ++YLH+ +PPI+H Sbjct: 616 TQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHN-RNPPIVH 674 Query: 594 GDVKTSNILLDE 629 D+K+ N+L+D+ Sbjct: 675 RDLKSPNLLVDK 686
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 67.8 bits (164), Expect = 3e-11 Identities = 46/148 (31%), Positives = 76/148 (51%), Gaps = 18/148 (12%) Frame = +3 Query: 240 IGKGANGTVYKGTT------KDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ +D LVA+K + AS+ +K+F +E +++ + H +IVK Sbjct: 544 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKF 603 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTAR------------LNIAHQTA 545 YG C+E + ++V++Y+ +G L + + R GP A L+IA Q A Sbjct: 604 YGVCVEGDPLIMVFEYMKHGDLNKFL--RAHGPDAVLMAEGNPPTELTQSQMLHIAQQIA 661 Query: 546 EALSYLHSWASPPIIHGDVKTSNILLDE 629 + YL AS +H D+ T N L+ E Sbjct: 662 AGMVYL---ASQHFVHRDLATRNCLVGE 686
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 67.8 bits (164), Expect = 3e-11 Identities = 46/148 (31%), Positives = 76/148 (51%), Gaps = 18/148 (12%) Frame = +3 Query: 240 IGKGANGTVYKGTT------KDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ +D LVA+K + AS+ +K+F +E +++ + H +IVK Sbjct: 540 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKF 599 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTAR------------LNIAHQTA 545 YG C+E + ++V++Y+ +G L + + R GP A L+IA Q A Sbjct: 600 YGVCVEGDPLIMVFEYMKHGDLNKFL--RAHGPDAVLMAEGNRPAELTQSQMLHIAQQIA 657 Query: 546 EALSYLHSWASPPIIHGDVKTSNILLDE 629 + YL AS +H D+ T N L+ E Sbjct: 658 AGMVYL---ASQHFVHRDLATRNCLVGE 682
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 67.8 bits (164), Expect = 3e-11 Identities = 46/148 (31%), Positives = 76/148 (51%), Gaps = 18/148 (12%) Frame = +3 Query: 240 IGKGANGTVYKGTT------KDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ +D LVA+K + AS+ +K+F +E +++ + H +IVK Sbjct: 543 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKF 602 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTAR------------LNIAHQTA 545 YG C+E + ++V++Y+ +G L + + R GP A L+IA Q A Sbjct: 603 YGVCVEGDPLIMVFEYMKHGDLNKFL--RAHGPDAVLMAEGNPPTELTQSQMLHIAQQIA 660 Query: 546 EALSYLHSWASPPIIHGDVKTSNILLDE 629 + YL AS +H D+ T N L+ E Sbjct: 661 AGMVYL---ASQHFVHRDLATRNCLVGE 685
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 67.8 bits (164), Expect = 3e-11 Identities = 46/148 (31%), Positives = 76/148 (51%), Gaps = 18/148 (12%) Frame = +3 Query: 240 IGKGANGTVYKGTT------KDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ +D LVA+K + AS+ +K+F +E +++ + H +IVK Sbjct: 543 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKF 602 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTAR------------LNIAHQTA 545 YG C+E + ++V++Y+ +G L + + R GP A L+IA Q A Sbjct: 603 YGVCVEGDPLIMVFEYMKHGDLNKFL--RAHGPDAVLMAEGNPPTELTQSQMLHIAQQIA 660 Query: 546 EALSYLHSWASPPIIHGDVKTSNILLDE 629 + YL AS +H D+ T N L+ E Sbjct: 661 AGMVYL---ASQHFVHRDLATRNCLVGE 685
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 67.4 bits (163), Expect = 3e-11 Identities = 51/152 (33%), Positives = 74/152 (48%), Gaps = 15/152 (9%) Frame = +3 Query: 219 RFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQ----KEFGKEMLIVSQINHR 386 R + + +IG G G VY+ T + E VA+K R E+ + +E + + + H Sbjct: 123 RLELKELIGAGGFGQVYRATWQGQE-VAVKAARQDPEQDAAAAAESVRREARLFAMLRHP 181 Query: 387 YIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHG-------RRDGPR----IPFTARLNIA 533 I++L G CL+ LV ++ G L R + R GPR IP +N A Sbjct: 182 NIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWA 241 Query: 534 HQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 Q A + YLH A PI+H D+K+SNILL E Sbjct: 242 VQIARGMLYLHEEAFVPILHRDLKSSNILLLE 273
>LIMK1_DROME (Q8IR79) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (dLIMK)| Length = 1257 Score = 67.0 bits (162), Expect = 4e-11 Identities = 41/131 (31%), Positives = 72/131 (54%), Gaps = 1/131 (0%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCL 416 +G+G G V+K T + + E++ +K+ A E Q+ F KE+ ++ ++HR+++K G Sbjct: 407 LGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLY 466 Query: 417 EVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHG 596 + + +V +Y+ G L LIH +P+ R+ +A A +SYLHS IIH Sbjct: 467 KDKKLHMVTEYVAGGCLKELIHD--PAQVLPWPQRVRLARDIACGMSYLHSM---NIIHR 521 Query: 597 DVKTSNILLDE 629 D+ + N L+ E Sbjct: 522 DLNSMNCLVRE 532
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 66.6 bits (161), Expect = 6e-11 Identities = 44/129 (34%), Positives = 73/129 (56%), Gaps = 4/129 (3%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNELVAIKKCRL---ASERQQKEFGKEMLIVSQINHRYIVKLYG 407 +IG G+ G VYKG + N++VAIK+ R S+ F +E+ I+ Q+NH +++ G Sbjct: 467 IIGSGSFGKVYKGRCR-NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVG 525 Query: 408 CCL-EVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPP 584 CL + +V +YI G+L+ L+H ++ + ++L IA A + YLH+ + P Sbjct: 526 ACLNDPSQFAIVTQYISGGSLFSLLHEQK--RILDLQSKLIIAVDVARGMEYLHN-LTQP 582 Query: 585 IIHGDVKTS 611 IIH D+ S Sbjct: 583 IIHRDLNRS 591
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 66.2 bits (160), Expect = 7e-11 Identities = 44/138 (31%), Positives = 70/138 (50%), Gaps = 4/138 (2%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDNELVAIKKC----RLASERQQKEFGKEMLIVSQINHRY 389 F+ +GKG G VY K V+ KC L +K+F +E+ I S + H Sbjct: 99 FEIGKALGKGKFGKVYLVKDKKTGFVSALKCMEKKELVEGNVEKQFRREVEIQSNLRHTN 158 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHS 569 +++L+G + + L+ +Y+ +G LY+L+ R+ R + + +Q +EAL YLH Sbjct: 159 VLRLFGHFHDKDRVYLILEYVVHGELYKLL---RNQKRFTESTASSYIYQMSEALLYLH- 214 Query: 570 WASPPIIHGDVKTSNILL 623 IIH D+K NILL Sbjct: 215 --GKNIIHRDIKPENILL 230
>SSK2_YEAST (P53599) MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of| sensor kinase 2) Length = 1579 Score = 66.2 bits (160), Expect = 7e-11 Identities = 52/162 (32%), Positives = 79/162 (48%), Gaps = 6/162 (3%) Frame = +3 Query: 159 SRQGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLA-SER 332 S +G + + + + R+ +RN IG G G VY DN E++A+K+ + S+ Sbjct: 1245 SDKGNKYLVSLASSISNVSMRWQKRNFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKS 1304 Query: 333 QQKEFG---KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLI-HGRRDGP 500 QK F +EM ++ +NH IV YG + + + +Y G+L L+ HGR + Sbjct: 1305 MQKIFPLIKEEMSVLEILNHPNIVSYYGVEVHRDKVNIFMEYCEGGSLAALLEHGRIEDE 1364 Query: 501 RIPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 + L Q E L+YLH I+H DVK NILLD Sbjct: 1365 MVTQVYTL----QLLEGLAYLH---ESGIVHRDVKPENILLD 1399
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 65.9 bits (159), Expect = 1e-10 Identities = 53/192 (27%), Positives = 94/192 (48%), Gaps = 10/192 (5%) Frame = +3 Query: 84 KRRLAKIKREYFEQHGGLTLFDEMRSRQGLSFKL--------FTQEELEEATGRFDERNV 239 K+R + I+ E + G DE+ ++G KL T +++ ATG+ V Sbjct: 326 KKRKSSIESEDDLEEGDEE--DEIGEKEGGEGKLVVFQGGENLTLDDVLNATGQ-----V 378 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 + K + GTVYK D +A++ R + + + + + +I H +V L Sbjct: 379 MEKTSYGTVYKAKLSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRAFYQG 438 Query: 420 VE-VPMLVYKYIPNGTLYRLIHGRRDG-PRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 +L+Y Y+PN +L+ L+H + P + + R IA A L+YLH+ PIIH Sbjct: 439 KRGEKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKIALGIARGLAYLHTGQEVPIIH 498 Query: 594 GDVKTSNILLDE 629 G++++ N+L+D+ Sbjct: 499 GNIRSKNVLVDD 510
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 65.1 bits (157), Expect = 2e-10 Identities = 46/141 (32%), Positives = 72/141 (51%), Gaps = 4/141 (2%) Frame = +3 Query: 216 GRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLA---SERQQKEFGKEMLIVSQINHR 386 G F +G G G VYK + KC + +R++ E +E + R Sbjct: 20 GEFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFR 79 Query: 387 YIVKLYGCCLEVEVPM-LVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYL 563 YI+ +YG C E P+ LV +Y+ G+L +L+ +P+ R I H+TA +++L Sbjct: 80 YILPVYGICRE---PVGLVMEYMETGSLEKLLASEP----LPWDLRFRIIHETAVGMNFL 132 Query: 564 HSWASPPIIHGDVKTSNILLD 626 H A PP++H D+K +NILLD Sbjct: 133 HCMA-PPLLHLDLKPANILLD 152
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 64.7 bits (156), Expect = 2e-10 Identities = 43/144 (29%), Positives = 72/144 (50%), Gaps = 1/144 (0%) Frame = +3 Query: 195 EELEEATGRFDERNVIGKGANGTVYKGTTKD-NELVAIKKCRLASERQQKEFGKEMLIVS 371 + E + ++ + VIG+G+ G VYK K +++VAIK+ ++ + + E+ ++ Sbjct: 16 QRASEKSVQYHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLK 75 Query: 372 QINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEA 551 +NH IVK +G + ++ +Y NG+L RLI R + QT Sbjct: 76 NLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLI--SRSSTGLSENESKTYVTQTLLG 133 Query: 552 LSYLHSWASPPIIHGDVKTSNILL 623 L YLH +IH D+K +NILL Sbjct: 134 LKYLH---GEGVIHRDIKAANILL 154
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 63.9 bits (154), Expect = 4e-10 Identities = 41/132 (31%), Positives = 66/132 (50%), Gaps = 1/132 (0%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNELVAIKKCRLASERQQK-EFGKEMLIVSQINHRYIVKLYGCC 413 ++GKG G VYKGT KD VA+K C+ ++ K +F +E I+ Q +H IVKL G C Sbjct: 69 LLGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVC 128 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + ++ + +P G + R+D ++ R ++ A + YL IH Sbjct: 129 TQRQPVYIIMELVPGGDFLSFLRKRKDELKLKQLVRFSL--DVAAGMLYLE---GKNCIH 183 Query: 594 GDVKTSNILLDE 629 D+ N L+ E Sbjct: 184 RDLAARNCLVGE 195
>SSK22_YEAST (P25390) Serine/threonine-protein kinase SSK22 (EC 2.7.11.1) (MAP| kinase kinase kinase SSK22) (Suppressor of sensor kinase 22) Length = 1331 Score = 63.5 bits (153), Expect = 5e-10 Identities = 45/160 (28%), Positives = 76/160 (47%), Gaps = 6/160 (3%) Frame = +3 Query: 165 QGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQK 341 QG + L L + R+ +R+ IG G G VY +N E++A+K+ ++ K Sbjct: 1015 QGNKYLLSLASSLSNVSMRWQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMK 1074 Query: 342 EF----GKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLI-HGRRDGPRI 506 + +EM ++ +NH IV+ YG + + + +Y G+L L+ HGR + + Sbjct: 1075 KIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDHGRIEDEMV 1134 Query: 507 PFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 + E L+YLH ++H D+K NILLD Sbjct: 1135 TQV----YTFELLEGLAYLH---QSGVVHRDIKPENILLD 1167
>PAKM_DROME (Q9VXE5) Serine/threonine-protein kinase PAK mbt (EC 2.7.11.1)| (p21-activated kinase-related protein) (Protein mushroom bodies tiny) Length = 639 Score = 62.8 bits (151), Expect = 8e-10 Identities = 44/135 (32%), Positives = 71/135 (52%), Gaps = 2/135 (1%) Frame = +3 Query: 225 DERNVIGKGANGTVYKGTTKD-NELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 D N IG+G+ GTV T K VA+KK L +++++ E++I+ +H IV+ Sbjct: 369 DHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVET 428 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLI-HGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 Y L + +V +Y+ G L ++ H R D +I + Q +AL+YLHS Sbjct: 429 YSSFLVNDELWVVMEYLEGGALTDIVTHSRMDEEQI-----ATVCKQCLKALAYLHSQG- 482 Query: 579 PPIIHGDVKTSNILL 623 +IH D+K+ +ILL Sbjct: 483 --VIHRDIKSDSILL 495
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 62.8 bits (151), Expect = 8e-10 Identities = 48/139 (34%), Positives = 70/139 (50%), Gaps = 4/139 (2%) Frame = +3 Query: 225 DERNVIGKGANGTVYKGTTKDNELVAIKKCRLASE----RQQKEFGKEMLIVSQINHRYI 392 D + VIG G V++G D E VAIK E R + +E + + H I Sbjct: 143 DIKEVIGSGGFCKVHRGYY-DGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENI 201 Query: 393 VKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSW 572 L G CL ++ LV +Y G+L R++ G+ IP +N A Q A ++YLH+ Sbjct: 202 AALRGVCLNTKL-CLVMEYARGGSLNRILAGK-----IPPDVLVNWAIQIARGMNYLHNE 255 Query: 573 ASPPIIHGDVKTSNILLDE 629 A IIH D+K+SN+L+ E Sbjct: 256 APMSIIHRDLKSSNVLIYE 274
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 62.8 bits (151), Expect = 8e-10 Identities = 45/133 (33%), Positives = 68/133 (51%), Gaps = 4/133 (3%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKE----FGKEMLIVSQINHRYIVKLY 404 +IG G G VY+ +E VA+K R + + +E + + + H I+ L Sbjct: 149 IIGIGGFGKVYRAFWIGDE-VAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 207 Query: 405 GCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPP 584 G CL+ LV ++ G L R++ G+R IP +N A Q A ++YLH A P Sbjct: 208 GVCLKEPNLCLVMEFARGGPLNRVLSGKR----IPPDILVNWAVQIARGMNYLHDEAIVP 263 Query: 585 IIHGDVKTSNILL 623 IIH D+K+SNIL+ Sbjct: 264 IIHRDLKSSNILI 276
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 62.4 bits (150), Expect = 1e-09 Identities = 41/149 (27%), Positives = 77/149 (51%), Gaps = 4/149 (2%) Frame = +3 Query: 195 EELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIK----KCRLASERQQKEFGKEML 362 + + E T F + +IG+G VY+ + N+ A+K + ++ ++ K F E+ Sbjct: 169 QSILEGTKHFHKDFLIGEGEIFEVYRVDIR-NQAYAVKLFKQEKKMQLKKHWKRFLSELE 227 Query: 363 IVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQT 542 ++ H +I++L E E LVY Y+ NGTL+ + + + R+++ Sbjct: 228 VLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGI 287 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILLDE 629 A+A+ YLH+ +I G+V ++NILLD+ Sbjct: 288 AKAIQYLHNTQPCAVICGNVSSANILLDD 316
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 62.4 bits (150), Expect = 1e-09 Identities = 42/131 (32%), Positives = 70/131 (53%), Gaps = 2/131 (1%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNEL-VAIKKCRLA-SERQQKEFGKEMLIVSQINHRYIVKLYGCC 413 IG+G G VYK K +L VA+K CR+ + Q+++F +E I+ Q +H IVKL G C Sbjct: 1069 IGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGIC 1128 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 ++ + M+V + + G+L L + R++ + ++ + A + YL S IH Sbjct: 1129 VQKQPIMIVMELVLGGSL--LTYLRKNSNGLTTRQQMGMCRDAAAGMRYLE---SKNCIH 1183 Query: 594 GDVKTSNILLD 626 D+ N L+D Sbjct: 1184 RDLAARNCLVD 1194
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 19/147 (12%) Frame = +3 Query: 240 IGKGANGTVYKGT------TKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ TKD LVA+K + + +K+F +E +++ + H +IVK Sbjct: 544 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 603 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLI--HG-----------RRDGPRIPFTARLNIAHQT 542 YG C + + ++V++Y+ +G L + + HG R+ + + L+IA Q Sbjct: 604 YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQI 663 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILL 623 A + YL AS +H D+ T N L+ Sbjct: 664 ASGMVYL---ASQHFVHRDLATRNCLV 687
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 19/147 (12%) Frame = +3 Query: 240 IGKGANGTVYKGT------TKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ TKD LVA+K + + +K+F +E +++ + H +IVK Sbjct: 544 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 603 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLI--HG-----------RRDGPRIPFTARLNIAHQT 542 YG C + + ++V++Y+ +G L + + HG R+ + + L+IA Q Sbjct: 604 YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQI 663 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILL 623 A + YL AS +H D+ T N L+ Sbjct: 664 ASGMVYL---ASQHFVHRDLATRNCLV 687
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 19/147 (12%) Frame = +3 Query: 240 IGKGANGTVYKGT------TKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ TKD LVA+K + + +K+F +E +++ + H +IVK Sbjct: 544 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 603 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLI--HG-----------RRDGPRIPFTARLNIAHQT 542 YG C + + ++V++Y+ +G L + + HG R+ + + L+IA Q Sbjct: 604 YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQI 663 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILL 623 A + YL AS +H D+ T N L+ Sbjct: 664 ASGMVYL---ASQHFVHRDLATRNCLV 687
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 62.0 bits (149), Expect = 1e-09 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 19/147 (12%) Frame = +3 Query: 240 IGKGANGTVYKGT------TKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ TKD LVA+K + + +K+F +E +++ + H +IVK Sbjct: 544 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 603 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLI--HG-----------RRDGPRIPFTARLNIAHQT 542 YG C + + ++V++Y+ +G L + + HG R+ + + L+IA Q Sbjct: 604 YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQI 663 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILL 623 A + YL AS +H D+ T N L+ Sbjct: 664 ASGMVYL---ASQHFVHRDLATRNCLV 687
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 61.6 bits (148), Expect = 2e-09 Identities = 40/151 (26%), Positives = 72/151 (47%), Gaps = 3/151 (1%) Frame = +3 Query: 186 FTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQ---QKEFGKE 356 +++ ++ +AT F++ I +G VY+G V K A ++ F E Sbjct: 198 WSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAE 257 Query: 357 MLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAH 536 + I + H ++ + G C + +Y Y+ NG+L + G+ +P+ R++I Sbjct: 258 LQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICS 317 Query: 537 QTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 A+ YLH IIH +VK+SN+LLD+ Sbjct: 318 GLLCAVEYLHGL---EIIHSNVKSSNVLLDQ 345
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 61.6 bits (148), Expect = 2e-09 Identities = 39/128 (30%), Positives = 69/128 (53%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 +G G+ G V K T ++ E +A+K E +K +E+ +S+I+H ++++ G Sbjct: 17 LGAGSGGAVRKATFQNQE-IAVKIFDFLEETIKKNAEREITHLSEIDHENVIRVIGRASN 75 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 + L+ +Y+ G+L+ ++G D + A Q A+AL+YLHS PI+H D Sbjct: 76 GKKDYLLMEYLEEGSLHNYLYG-DDKWEYTVEQAVRWALQCAKALAYLHS-LDRPIVHRD 133 Query: 600 VKTSNILL 623 +K N+LL Sbjct: 134 IKPQNMLL 141
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/138 (29%), Positives = 71/138 (51%), Gaps = 4/138 (2%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDNELV----AIKKCRLASERQQKEFGKEMLIVSQINHRY 389 F+ ++GKG G VY ++ L+ A++K + QK+F +E+ I H+ Sbjct: 100 FEIGKILGKGKFGKVYCVKHRETGLICALKAMEKKEIVQYTIQKQFRREVEIQGSFKHKN 159 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHS 569 + +LYG + + L+ +Y+ G LY+ + + +GP + T +Q A AL Y+H Sbjct: 160 LTQLYGFFYDEKRVYLLMEYVYYGELYKFL--KNNGP-LNETLASYFVYQMANALDYMH- 215 Query: 570 WASPPIIHGDVKTSNILL 623 S I+H D+K NIL+ Sbjct: 216 --SKNILHRDIKPENILI 231
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 60.8 bits (146), Expect = 3e-09 Identities = 44/139 (31%), Positives = 77/139 (55%), Gaps = 9/139 (6%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDN-ELVAIKKCRLAS-----ERQQ---KEFGKEMLIVSQINHRY 389 +IG+GA GTVY G D+ EL+A+K+ +A+ E+ Q +E +E+ ++ ++H Sbjct: 74 LIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPN 133 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHS 569 IV+ G E + ++ +++P G++ L+ + GP P + Q L YLH+ Sbjct: 134 IVRYLGTVREDDTLNILLEFVPGGSISSLL--EKFGP-FPESVVRTYTRQLLLGLEYLHN 190 Query: 570 WASPPIIHGDVKTSNILLD 626 A I+H D+K +NIL+D Sbjct: 191 HA---IMHRDIKGANILVD 206
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 60.8 bits (146), Expect = 3e-09 Identities = 52/185 (28%), Positives = 93/185 (50%), Gaps = 3/185 (1%) Frame = +3 Query: 84 KRRLAKIKREYFEQHGGLTLFDEMRSRQGLSFKLFTQEELEEATGRFDERNVIGKGANGT 263 K L I+R + T F+E++S G + +++ F ++ +G+GA Sbjct: 69 KESLNDIQRAIESEKIKKTKFEELKSILGEREYIIDINDIQ-----FIQK--VGEGAFSE 121 Query: 264 VYKGTTKDNELVAIKKCRLASERQQ--KEFGKEMLIVSQINHRYIVKLYGCCLEVEVPML 437 V++G K VAIKK ++ + +Q + F +E+ + + NH+ IV G C + + Sbjct: 122 VWEGWWKGIH-VAIKKLKIIGDEEQFKERFIREVQNLKKGNHQNIVMFIGACYKPAC--I 178 Query: 438 VYKYIPNGTLYRLIHGRRDG-PRIPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSN 614 + +Y+ G+LY ++H P++ ++ L + T AL LH S I+H D+ + N Sbjct: 179 ITEYMAGGSLYNILHNPNSSTPKVKYSFPLVLKMATDMALGLLHLH-SITIVHRDLTSQN 237 Query: 615 ILLDE 629 ILLDE Sbjct: 238 ILLDE 242
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 60.5 bits (145), Expect = 4e-09 Identities = 39/132 (29%), Positives = 66/132 (50%), Gaps = 1/132 (0%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNELVAIKKCRLASERQQK-EFGKEMLIVSQINHRYIVKLYGCC 413 ++GKG G VYKGT KD VA+K C+ ++ K +F +E I+ Q +H IVKL G C Sbjct: 568 LLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVC 627 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + ++ + + G + ++D ++ + ++ A + YL S IH Sbjct: 628 TQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSL--DAAAGMLYLE---SKNCIH 682 Query: 594 GDVKTSNILLDE 629 D+ N L+ E Sbjct: 683 RDLAARNCLVGE 694
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 60.1 bits (144), Expect = 5e-09 Identities = 42/137 (30%), Positives = 73/137 (53%), Gaps = 7/137 (5%) Frame = +3 Query: 240 IGKGANGTVYKG----TTKDNELVAIKKCR-LASERQQKEFGKEMLIVSQINHRYIVKLY 404 +G+GA G VYKG K VAIK + AS + Q++F +E+ ++S + H+ IV + Sbjct: 416 LGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCIL 475 Query: 405 GCCLEVEVPMLVYKYIPNGTLYRLI--HGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G L E ++++Y+ NG L+ + + +G + L IA Q +E + YL ++ Sbjct: 476 GVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQIALQISEGMQYL---SA 532 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N L++E Sbjct: 533 HHYVHRDLAARNCLVNE 549
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 60.1 bits (144), Expect = 5e-09 Identities = 44/145 (30%), Positives = 77/145 (53%), Gaps = 9/145 (6%) Frame = +3 Query: 219 RFDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLAS-----ERQQ---KEFGKEMLIVS 371 R+ + +IG+GA GTVY G D+ EL+A+K+ + S E+ Q +E +E+ ++ Sbjct: 67 RWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLK 126 Query: 372 QINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEA 551 ++H IV+ G E E ++ +++P G++ L+ P + +Q Sbjct: 127 NLSHPNIVRYLGTVREDETLNILLEFVPGGSISSLL---EKFGAFPESVVRTYTNQLLLG 183 Query: 552 LSYLHSWASPPIIHGDVKTSNILLD 626 L YLH+ A I+H D+K +NIL+D Sbjct: 184 LEYLHNHA---IMHRDIKGANILVD 205
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 60.1 bits (144), Expect = 5e-09 Identities = 42/147 (28%), Positives = 74/147 (50%), Gaps = 19/147 (12%) Frame = +3 Query: 240 IGKGANGTVYKGT------TKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ T D LVA+K + + +K+F +E +++ + H +IVK Sbjct: 546 LGEGAFGKVFLAECYNLSPTNDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 605 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLI--HG-----------RRDGPRIPFTARLNIAHQT 542 YG C + + ++V++Y+ +G L + + HG R+ + + L+IA Q Sbjct: 606 YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQI 665 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILL 623 A + YL AS +H D+ T N L+ Sbjct: 666 ASGMVYL---ASQHFVHRDLATRNCLV 689
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 59.7 bits (143), Expect = 7e-09 Identities = 40/141 (28%), Positives = 68/141 (48%), Gaps = 4/141 (2%) Frame = +3 Query: 219 RFDERNVIGKGANGTVYKGTTK-DNELVAIKKCR---LASERQQKEFGKEMLIVSQINHR 386 R++ + +GKG G V + T + +VAIK R + E+ +E+ I+S +NH Sbjct: 54 RYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHP 113 Query: 387 YIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLH 566 +I+ +Y + +++ +Y G LY I RR R+ + Q A+ Y H Sbjct: 114 HIISIYEVFENKDKIVIIMEYASKGELYDYISERR---RLSERETRHFFRQIVSAVHYCH 170 Query: 567 SWASPPIIHGDVKTSNILLDE 629 ++H D+K NILLD+ Sbjct: 171 KNG---VVHRDLKLENILLDD 188
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 59.7 bits (143), Expect = 7e-09 Identities = 42/146 (28%), Positives = 72/146 (49%), Gaps = 21/146 (14%) Frame = +3 Query: 240 IGKGANGTVYKGT------TKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ TKD LVA+K + + +K+F +E +++ + H +IVK Sbjct: 544 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 603 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGP---------------RIPFTARLNIAH 536 YG C + + ++V++Y+ +G L + + R GP + + L+IA Sbjct: 604 YGVCGDGDPLIMVFEYMKHGDLNKFL--RAHGPDAMILVDGQPXQAKGELGLSQMLHIAS 661 Query: 537 QTAEALSYLHSWASPPIIHGDVKTSN 614 Q A + YL AS +H D+ T N Sbjct: 662 QIASGMVYL---ASQHFVHRDLATRN 684
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 59.7 bits (143), Expect = 7e-09 Identities = 42/148 (28%), Positives = 73/148 (49%), Gaps = 20/148 (13%) Frame = +3 Query: 240 IGKGANGTVYKGTT------KDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ ++ LVA+K + +E + +F +E +++ + H +IVK Sbjct: 499 LGEGAFGKVFLAECSHLLPEQEKTLVAVKALKEVTENARLDFQREAELLTVLQHEHIVKF 558 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGP--------------RIPFTARLNIAHQ 539 YG C E + ++V++Y+ +G L R + R GP ++ + L IA Q Sbjct: 559 YGVCTEGDPLIMVFEYMKHGDLNRFL--RSHGPDAKILDQGQGQPCGQLTLSHMLQIATQ 616 Query: 540 TAEALSYLHSWASPPIIHGDVKTSNILL 623 A + YL AS +H D+ T N L+ Sbjct: 617 IASGMVYL---ASLHFVHRDLATRNCLV 641
>ROS_CHICK (P08941) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2311 Score = 59.3 bits (142), Expect = 9e-09 Identities = 44/143 (30%), Positives = 68/143 (47%), Gaps = 12/143 (8%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKD-------NELVAIKKC-RLASERQQKEFGKEMLIVSQINHRYI 392 ++G GA G VY+GT D VA+K R A+++++ EF KE ++S+ +H +I Sbjct: 1966 LLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMSKFDHPHI 2025 Query: 393 VKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRR----DGPRIPFTARLNIAHQTAEALSY 560 +KL G CL E L+ + + G L + G R P + T L+I + Y Sbjct: 2026 LKLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLDICLDICKGCVY 2085 Query: 561 LHSWASPPIIHGDVKTSNILLDE 629 L IH D+ N L+ E Sbjct: 2086 LEKMR---FIHRDLAARNCLVSE 2105
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 59.3 bits (142), Expect = 9e-09 Identities = 44/138 (31%), Positives = 69/138 (50%), Gaps = 4/138 (2%) Frame = +3 Query: 222 FDERNVIGKGANGTVY----KGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRY 389 F+ +GKG G VY + T L ++K + QK+F +E+ I + +NH Sbjct: 104 FELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLNHPN 163 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHS 569 + K YG + + L+ +Y+ NG +Y+L+ R GP A + +Q A AL Y+H Sbjct: 164 LTKSYGYFHDEKRVYLLMEYLVNGEMYKLL--RLHGPFNDILAS-DYIYQIANALDYMH- 219 Query: 570 WASPPIIHGDVKTSNILL 623 IIH D+K NIL+ Sbjct: 220 --KKNIIHRDIKPENILI 235
>MST4_MOUSE (Q99JT2) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) Length = 416 Score = 59.3 bits (142), Expect = 9e-09 Identities = 44/148 (29%), Positives = 75/148 (50%), Gaps = 2/148 (1%) Frame = +3 Query: 192 QEELEEATGRFDERNVIGKGANGTVYKGT-TKDNELVAIKKCRLA-SERQQKEFGKEMLI 365 Q + + F + IGKG+ G V+KG + ++VAIK L +E + ++ +E+ + Sbjct: 14 QNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITV 73 Query: 366 VSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTA 545 +SQ + Y+ K YG L+ ++ +Y+ G+ L+ R GP F + + Sbjct: 74 LSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLL---RAGPFDEFQIA-TMLKEIL 129 Query: 546 EALSYLHSWASPPIIHGDVKTSNILLDE 629 + L YLHS IH D+K +N+LL E Sbjct: 130 KGLDYLHSEKK---IHRDIKAANVLLSE 154
>MST4_HUMAN (Q9P289) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase) Length = 416 Score = 59.3 bits (142), Expect = 9e-09 Identities = 44/148 (29%), Positives = 75/148 (50%), Gaps = 2/148 (1%) Frame = +3 Query: 192 QEELEEATGRFDERNVIGKGANGTVYKGT-TKDNELVAIKKCRLA-SERQQKEFGKEMLI 365 Q + + F + IGKG+ G V+KG + ++VAIK L +E + ++ +E+ + Sbjct: 14 QNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITV 73 Query: 366 VSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTA 545 +SQ + Y+ K YG L+ ++ +Y+ G+ L+ R GP F + + Sbjct: 74 LSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLL---RAGPFDEFQIA-TMLKEIL 129 Query: 546 EALSYLHSWASPPIIHGDVKTSNILLDE 629 + L YLHS IH D+K +N+LL E Sbjct: 130 KGLDYLHSEKK---IHRDIKAANVLLSE 154
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 59.3 bits (142), Expect = 9e-09 Identities = 47/140 (33%), Positives = 68/140 (48%), Gaps = 4/140 (2%) Frame = +3 Query: 216 GRFDERNVIGKGANGTVYKGTTKDNE-LVAIK---KCRLASERQQKEFGKEMLIVSQINH 383 G F+ +GKG G VY K +VA+K K L + +K+ +E+ I S + H Sbjct: 87 GMFEIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRH 146 Query: 384 RYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYL 563 + I++LYG + + L+ ++ G LY+ H RR R Q A ALSYL Sbjct: 147 KNILRLYGHFHDEKRIYLILEFAGRGELYQ--HLRR-AKRFSEEVASKYIFQMANALSYL 203 Query: 564 HSWASPPIIHGDVKTSNILL 623 H +IH D+K NILL Sbjct: 204 H---KKHVIHRDIKPENILL 220
>LIMK1_XENLA (O42565) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (xLIMK1)| Length = 615 Score = 59.3 bits (142), Expect = 9e-09 Identities = 39/132 (29%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +3 Query: 237 VIGKGANGTVYKGTTK-DNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCC 413 V+G+G G K T + E++ +K+ E Q+ F KE+ ++ + H +++K G Sbjct: 319 VLGRGCFGQAIKVTHRVTGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPHVLKFIGVL 378 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + + +YIP GTL R+I + P+ R++ A A ++YLHS IIH Sbjct: 379 YKDKRLNFITEYIPGGTLRRVI--KSMDTHCPWNQRVSFARDIAAGMTYLHSM---NIIH 433 Query: 594 GDVKTSNILLDE 629 D+ + N L+ E Sbjct: 434 RDLNSHNCLVRE 445
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 59.3 bits (142), Expect = 9e-09 Identities = 41/149 (27%), Positives = 76/149 (51%), Gaps = 4/149 (2%) Frame = +3 Query: 195 EELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIK----KCRLASERQQKEFGKEML 362 + + E T F + +IG+G VY+ + N A+K + ++ ++ K F E+ Sbjct: 156 QNIIEGTRNFHKDFLIGEGEIFEVYRVEIQ-NLTYAVKLFKQEKKMQCKKHWKRFLSELE 214 Query: 363 IVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQT 542 ++ +H I++L E E L+Y Y+ NGTL+ + D +P+ R+ I Sbjct: 215 VLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGI 274 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILLDE 629 ++A+ YLH+ +I G + ++NILLD+ Sbjct: 275 SKAIHYLHNVQPCSVICGSISSANILLDD 303
>ROS_AVISU (P00529) Tyrosine-protein kinase transforming protein ros (EC| 2.7.10.1) Length = 402 Score = 59.3 bits (142), Expect = 9e-09 Identities = 44/143 (30%), Positives = 68/143 (47%), Gaps = 12/143 (8%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKD-------NELVAIKKC-RLASERQQKEFGKEMLIVSQINHRYI 392 ++G GA G VY+GT D VA+K R A+++++ EF KE ++S+ +H +I Sbjct: 103 LLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMSKFDHPHI 162 Query: 393 VKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRR----DGPRIPFTARLNIAHQTAEALSY 560 +KL G CL E L+ + + G L + G R P + T L+I + Y Sbjct: 163 LKLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLDICLDICKGCVY 222 Query: 561 LHSWASPPIIHGDVKTSNILLDE 629 L IH D+ N L+ E Sbjct: 223 LEKMR---FIHRDLAARNCLVSE 242
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 58.9 bits (141), Expect = 1e-08 Identities = 42/150 (28%), Positives = 73/150 (48%), Gaps = 20/150 (13%) Frame = +3 Query: 240 IGKGANGTVYKG------TTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ +D LVA+K + SE +++F +E +++ + H++IV+ Sbjct: 519 LGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRF 578 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTA--------------RLNIAHQ 539 +G C E ++V++Y+ +G L R + R GP A L +A Q Sbjct: 579 FGVCTEGGPLLMVFEYMRHGDLNRFL--RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQ 636 Query: 540 TAEALSYLHSWASPPIIHGDVKTSNILLDE 629 A + YL AS +H D+ T N L+ + Sbjct: 637 VAAGMVYL---ASLHFVHRDLATRNCLVGQ 663
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase| 1) (JAK-1) Length = 1153 Score = 58.9 bits (141), Expect = 1e-08 Identities = 43/139 (30%), Positives = 69/139 (49%), Gaps = 11/139 (7%) Frame = +3 Query: 240 IGKGANGTVYKGTT---KDNELVA-------IKKCRLASERQ-QKEFGKEMLIVSQINHR 386 +G+G +Y GT KD E +A I K S R F + ++ Q++H+ Sbjct: 588 LGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHK 647 Query: 387 YIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLH 566 +IV LYG C+ ++V +++ G L +H + D P+ + +A Q A ALSYL Sbjct: 648 HIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPW--KFKVAKQLASALSYLE 705 Query: 567 SWASPPIIHGDVKTSNILL 623 ++HG+V T N+LL Sbjct: 706 ---DKDLVHGNVCTKNLLL 721 Score = 37.7 bits (86), Expect = 0.028 Identities = 30/115 (26%), Positives = 55/115 (47%), Gaps = 3/115 (2%) Frame = +3 Query: 291 ELVAIKKCRLASERQQ-KEFGKEMLIVSQINHRYIVKLYGCCLE--VEVPMLVYKYIPNG 461 E VA+K + S + KE+ I+ + H IVK G C+E L+ +++P+G Sbjct: 902 EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSG 961 Query: 462 TLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 +L + ++ +I +L A Q + + YL S +H D+ N+L++ Sbjct: 962 SLKEYLPKNKN--KINLKQQLKYAIQICKGMDYL---GSRQYVHRDLAARNVLVE 1011
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 58.9 bits (141), Expect = 1e-08 Identities = 42/150 (28%), Positives = 73/150 (48%), Gaps = 20/150 (13%) Frame = +3 Query: 240 IGKGANGTVYKGTT------KDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ +D LVA+K + ASE +++F +E +++ + H++IV+ Sbjct: 516 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRF 575 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTA--------------RLNIAHQ 539 +G C E ++V++Y+ +G L R + R GP A L +A Q Sbjct: 576 FGVCTEGRPLLMVFEYMRHGDLNRFL--RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQ 633 Query: 540 TAEALSYLHSWASPPIIHGDVKTSNILLDE 629 A + YL A +H D+ T N L+ + Sbjct: 634 VAAGMVYL---AGLHFVHRDLATRNCLVGQ 660
>STK25_MOUSE (Q9Z2W1) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 58.9 bits (141), Expect = 1e-08 Identities = 44/138 (31%), Positives = 73/138 (52%), Gaps = 2/138 (1%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLA-SERQQKEFGKEMLIVSQINHRYIV 395 F + + IGKG+ G VYKG E+VAIK L +E + ++ +E+ ++SQ + YI Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79 Query: 396 KLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWA 575 + +G L+ ++ +Y+ G+ L+ + GP + T I + + L YLHS Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLL---KPGP-LEETYIATILREILKGLDYLHSER 135 Query: 576 SPPIIHGDVKTSNILLDE 629 IH D+K +N+LL E Sbjct: 136 K---IHRDIKAANVLLSE 150
>STK25_HUMAN (O00506) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 58.9 bits (141), Expect = 1e-08 Identities = 44/138 (31%), Positives = 73/138 (52%), Gaps = 2/138 (1%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLA-SERQQKEFGKEMLIVSQINHRYIV 395 F + + IGKG+ G VYKG E+VAIK L +E + ++ +E+ ++SQ + YI Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79 Query: 396 KLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWA 575 + +G L+ ++ +Y+ G+ L+ + GP + T I + + L YLHS Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLL---KPGP-LEETYIATILREILKGLDYLHSER 135 Query: 576 SPPIIHGDVKTSNILLDE 629 IH D+K +N+LL E Sbjct: 136 K---IHRDIKAANVLLSE 150
>STK24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3) Length = 443 Score = 58.5 bits (140), Expect = 2e-08 Identities = 43/138 (31%), Positives = 72/138 (52%), Gaps = 2/138 (1%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGT-TKDNELVAIKKCRLA-SERQQKEFGKEMLIVSQINHRYIV 395 F + IGKG+ G V+KG + ++VAIK L +E + ++ +E+ ++SQ + Y+ Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 95 Query: 396 KLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWA 575 K YG L+ ++ +Y+ G+ L+ GP + T I + + L YLHS Sbjct: 96 KYYGSYLKDTKLWIIMEYLGGGSALDLLE---PGP-LDETQIATILREILKGLDYLHSEK 151 Query: 576 SPPIIHGDVKTSNILLDE 629 IH D+K +N+LL E Sbjct: 152 K---IHRDIKAANVLLSE 166
>TAOK3_RAT (Q53UA7) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory kinase) (Axotomy-related gene 357 protein) Length = 898 Score = 58.5 bits (140), Expect = 2e-08 Identities = 47/154 (30%), Positives = 75/154 (48%), Gaps = 4/154 (2%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKD-NELVAIKKCRLASERQQKEFG-- 350 +LF +E+ EE F + + IG G+ G VY T NE+VAIKK + ++ +++ Sbjct: 13 ELFFKEDPEEL---FIDLHEIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDI 69 Query: 351 -KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLN 527 KE+ + Q+ H ++ GC L+ LV +Y L ++ + A Sbjct: 70 LKEVRFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA--- 126 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 I H + L+YLH + +IH D+K NILL E Sbjct: 127 ITHGALQGLAYLHFHS---LIHRDIKAGNILLTE 157
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 58.5 bits (140), Expect = 2e-08 Identities = 40/141 (28%), Positives = 67/141 (47%), Gaps = 4/141 (2%) Frame = +3 Query: 219 RFDERNVIGKGANGTVYKGTTK-DNELVAIKKCR---LASERQQKEFGKEMLIVSQINHR 386 R++ + +GKG G V + T + +VAIK R + E +E+ I+S +NH Sbjct: 55 RYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHP 114 Query: 387 YIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLH 566 +I+ +Y + +++ +Y G LY I RR R+ + Q A+ Y H Sbjct: 115 HIISIYEVFENKDKIVIIMEYASKGELYDYISERR---RLSERETRHFFRQIVSAVHYCH 171 Query: 567 SWASPPIIHGDVKTSNILLDE 629 ++H D+K NILLD+ Sbjct: 172 KNG---VVHRDLKLENILLDD 189
>PKPA_PHYBL (Q01577) Serine/threonine-protein kinase pkpA (EC 2.7.11.1)| Length = 613 Score = 58.5 bits (140), Expect = 2e-08 Identities = 46/152 (30%), Positives = 73/152 (48%), Gaps = 8/152 (5%) Frame = +3 Query: 195 EELEEATG--RFDERN-VIGKGANGTVYKGTTK-----DNELVAIKKCRLASERQQKEFG 350 E++ EA+G R+ + N V+GKGA VYK + DNE+ +K R ++ K+ G Sbjct: 5 EKVIEASGNGRYSKLNTVLGKGAYKVVYKAIDREEAINDNEITNVKVTR----QEFKDLG 60 Query: 351 KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNI 530 E+ I+ + H I+ + + + + + +GTL I P I R Sbjct: 61 HEIDILKSVRHPNIITFHDAWYNETEFVFITELMTSGTLREYIRKLTPLPNIKIVKRW-- 118 Query: 531 AHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 Q + L+YLH PPIIH D+K NI ++ Sbjct: 119 CRQILKGLAYLHGH-EPPIIHRDIKCDNIFIN 149
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 58.2 bits (139), Expect = 2e-08 Identities = 41/132 (31%), Positives = 62/132 (46%), Gaps = 2/132 (1%) Frame = +3 Query: 240 IGKGANGTVYKGTTK-DNELVAIKKCRLASERQQK-EFGKEMLIVSQINHRYIVKLYGCC 413 IG+G G V+ G + DN VA+K CR + K +F +E I+ Q NH IV+L G C Sbjct: 618 IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQCNHPNIVRLIGVC 677 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + +V + + G + R GPR+ + + A + YL S IH Sbjct: 678 TQKQPIYIVMELVQGGDFLSFL--RSKGPRLKMKKLIKMMENAAAGMEYLE---SKHCIH 732 Query: 594 GDVKTSNILLDE 629 D+ N L+ E Sbjct: 733 RDLAARNCLVTE 744
>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a) Length = 692 Score = 58.2 bits (139), Expect = 2e-08 Identities = 41/140 (29%), Positives = 70/140 (50%), Gaps = 3/140 (2%) Frame = +3 Query: 219 RFDERNVIGKGANGTVYKGTTK-DNELVAIKKCRLA--SERQQKEFGKEMLIVSQINHRY 389 +++ V+G+GA G V+ K D +LV IK+ + ++ +++ E ++ +NH Sbjct: 3 KYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPN 62 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHS 569 +++ Y LE + M+ +Y P GTL I R + I H + L LH Sbjct: 63 VIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNS----LLEEETILHFFVQILLALHH 118 Query: 570 WASPPIIHGDVKTSNILLDE 629 + I+H D+KT NILLD+ Sbjct: 119 VHTHLILHRDLKTQNILLDK 138
>MET_MOUSE (P16056) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1379 Score = 58.2 bits (139), Expect = 2e-08 Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNE----LVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G VY GT DN+ A+K R+ + +F E +I+ +H ++ L Sbjct: 1081 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSL 1140 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL E P++V Y+ +G L I P + + Q A+ + YL AS Sbjct: 1141 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---AS 1195 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 1196 KKFVHRDLAARNCMLDE 1212
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 58.2 bits (139), Expect = 2e-08 Identities = 51/194 (26%), Positives = 84/194 (43%), Gaps = 9/194 (4%) Frame = +3 Query: 69 YMIYAKRRLAKIKR---EYFEQHGGLTLFDEMRSRQGLSFKLFTQEELEEATGRFDERNV 239 + +Y +R+ K KR + E L + ++ + EL+ V Sbjct: 671 FAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV-------KV 723 Query: 240 IGKGANGTVYKGT-TKDNELVAIKKC-----RLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G GA GTVYKG + E V I + EF E LI++ ++H ++V+L Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRL 783 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASP 581 G CL + LV + +P+G L +H +D I LN Q A+ + YL Sbjct: 784 LGVCLSPTI-QLVTQLMPHGCLLEYVHEHKD--NIGSQLLLNWCVQIAKGMMYLE---ER 837 Query: 582 PIIHGDVKTSNILL 623 ++H D+ N+L+ Sbjct: 838 RLVHRDLAARNVLV 851
>TAOK3_XENLA (Q6DD27) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 896 Score = 57.8 bits (138), Expect = 3e-08 Identities = 46/153 (30%), Positives = 73/153 (47%), Gaps = 4/153 (2%) Frame = +3 Query: 183 LFTQEELEEATGRFDERNVIGKGANGTVYKGTTKD-NELVAIKKCRLASERQQKEFG--- 350 LF +E+ E F + + IG G+ G VY T NE+VA+KK + ++ +++ Sbjct: 14 LFCKEDPERI---FVDLHEIGHGSFGAVYFATNSTTNEIVAVKKMSYSGKQMNEKWQDII 70 Query: 351 KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNI 530 KE+ + Q+ H ++ GC L+ LV +Y L ++ + A I Sbjct: 71 KEVKFLQQLKHPNTIEYKGCYLKDHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA---I 127 Query: 531 AHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 H + L+YLHS +IH D+K NILL E Sbjct: 128 THGALQGLAYLHSHN---MIHRDIKAGNILLTE 157
>KRAF1_CAEEL (Q07292) Raf homolog serine/threonine-protein kinase (EC 2.7.11.1)| (Abnormal cell lineage protein 45) Length = 813 Score = 57.8 bits (138), Expect = 3e-08 Identities = 46/147 (31%), Positives = 74/147 (50%), Gaps = 4/147 (2%) Frame = +3 Query: 195 EELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLA--SERQQKEFGKEMLIV 368 E+ E F + +G G+ GTVY+G VAIKK + + Q F E+ ++ Sbjct: 472 EDWEILPNEFIIQYKVGSGSFGTVYRGEFFGT--VAIKKLNVVDPTPSQMAAFKNEVAVL 529 Query: 369 SQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFT--ARLNIAHQT 542 + H ++ G E E+ ++ ++ +LYR IH + PR+ F A ++I Q Sbjct: 530 KKTRHLNVLLFMGWVREPEIAIIT-QWCEGSSLYRHIHVQE--PRVEFEMGAIIDILKQV 586 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILL 623 + ++YLH S IIH D+KT+NI L Sbjct: 587 SLGMNYLH---SKNIIHRDLKTNNIFL 610
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 57.8 bits (138), Expect = 3e-08 Identities = 35/138 (25%), Positives = 72/138 (52%), Gaps = 6/138 (4%) Frame = +3 Query: 234 NVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQ------KEFGKEMLIVSQINHRYIV 395 N GA+ +Y+G K VA+K R+ + +++ ++F E+ ++S++ H IV Sbjct: 90 NKFASGAHSRIYRGIYKQRA-VAVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNIV 148 Query: 396 KLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWA 575 + C + V ++ +Y+ G L R+ +++ + L +A + + YLHS Sbjct: 149 QFIAACKKPPVYCIITEYMSQGNL-RMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQG 207 Query: 576 SPPIIHGDVKTSNILLDE 629 +IH D+K++N+LL++ Sbjct: 208 ---VIHRDLKSNNLLLND 222
>TAOK3_PONPY (Q5R4F3) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 57.8 bits (138), Expect = 3e-08 Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 4/153 (2%) Frame = +3 Query: 183 LFTQEELEEATGRFDERNVIGKGANGTVYKGTTKD-NELVAIKKCRLASERQQKEFG--- 350 LF +++ EE F + IG G+ G VY T NE+VAIKK + ++ +++ Sbjct: 14 LFYKDDPEEL---FIGLHEIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDIL 70 Query: 351 KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNI 530 KE+ + Q+ H ++ GC L+ LV +Y L ++ + A I Sbjct: 71 KEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA---I 127 Query: 531 AHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 H L+YLHS A +IH D+K NILL E Sbjct: 128 THGALHGLAYLHSHA---LIHRDIKAGNILLTE 157
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 57.8 bits (138), Expect = 3e-08 Identities = 42/156 (26%), Positives = 79/156 (50%), Gaps = 11/156 (7%) Frame = +3 Query: 192 QEELEEATGRFDERNVIGKGANGTVYKG-TTKDNELVAIKKCRLASERQQKE-------- 344 +E+ ++ + ++ +IG G+ G VY G EL+A+K+ L S + K+ Sbjct: 384 EEDTDDQSIKWIRGALIGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDA 443 Query: 345 FGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLI--HGRRDGPRIPFTA 518 E+ ++ +++H +IV+ G L + + +Y+P G++ L+ +G + + Sbjct: 444 LAGEIALLQELSHEHIVQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLVK--- 500 Query: 519 RLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 N QT + L YLHS I+H D+K +NIL+D Sbjct: 501 --NFIKQTLKGLEYLHSRG---IVHRDIKGANILVD 531
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 57.4 bits (137), Expect = 3e-08 Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNE----LVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G VY GT DN+ A+K R+ + +F E +I+ +H ++ L Sbjct: 1084 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1143 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL E P++V Y+ +G L I P + + Q A+ + YL AS Sbjct: 1144 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---AS 1198 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 1199 KKFVHRDLAARNCMLDE 1215
>MET_MICMU (Q2QL89) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 57.4 bits (137), Expect = 3e-08 Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNE----LVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G VY GT DN+ A+K R+ + +F E +I+ +H ++ L Sbjct: 1084 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1143 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL E P++V Y+ +G L I P + + Q A+ + YL AS Sbjct: 1144 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---AS 1198 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 1199 KKFVHRDLAARNCMLDE 1215
>MET_CANFA (Q75ZY9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 57.4 bits (137), Expect = 3e-08 Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNE----LVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G VY GT DN+ A+K R+ + +F E +I+ +H ++ L Sbjct: 1084 VIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1143 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL E P++V Y+ +G L I P + + Q A+ + YL AS Sbjct: 1144 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---AS 1198 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 1199 KKFVHRDLAARNCMLDE 1215
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 57.4 bits (137), Expect = 3e-08 Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDNE-LVAIK---KCRLASERQQKEFGKEMLIVSQINHRY 389 F+ +G+G G VY K+N +VA+K K + E + + +E+ I + + HR Sbjct: 16 FEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRN 75 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLI--HGRRDGPRIPFTARLNIAHQTAEALSYL 563 I++LY + L+ +Y P G LY+ + H + D R I + ++AL+Y Sbjct: 76 ILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQKLDQQR-----TATIIQELSDALTYC 130 Query: 564 HSWASPPIIHGDVKTSNILL 623 H +IH D+K N+LL Sbjct: 131 H---EKKVIHRDIKPENLLL 147
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase| 1) (JAK-1) Length = 1142 Score = 57.4 bits (137), Expect = 3e-08 Identities = 39/139 (28%), Positives = 70/139 (50%), Gaps = 11/139 (7%) Frame = +3 Query: 240 IGKGANGTVY----------KGTTKDNELVAIKKCRLASERQ-QKEFGKEMLIVSQINHR 386 +G+G +Y +GT+++ ++ I K S R F + ++ Q++H+ Sbjct: 577 LGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHK 636 Query: 387 YIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLH 566 +IV LYG C+ ++V +++ G L +H + D P+ + +A Q A ALSYL Sbjct: 637 HIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPW--KFKVAKQLASALSYLE 694 Query: 567 SWASPPIIHGDVKTSNILL 623 ++HG+V T N+LL Sbjct: 695 ---DKDLVHGNVCTKNLLL 710 Score = 38.5 bits (88), Expect = 0.017 Identities = 35/136 (25%), Positives = 61/136 (44%), Gaps = 7/136 (5%) Frame = +3 Query: 240 IGKGANGTV----YKGTTKDNELVAIKKCRLASERQQ-KEFGKEMLIVSQINHRYIVKLY 404 +G+G G V Y E VA+K + S + KE+ I+ + H IVK Sbjct: 870 LGEGHFGKVELCRYDPEDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYK 929 Query: 405 GCCLE--VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G C E L+ +++P+G+L + ++ +I +L A Q + + YL S Sbjct: 930 GICTEDGGNGIKLIMEFLPSGSLKEYLPKNKN--KINLKQQLKYAVQICKGMDYL---GS 984 Query: 579 PPIIHGDVKTSNILLD 626 +H D+ N+L++ Sbjct: 985 RQYVHRDLAARNVLVE 1000
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 57.4 bits (137), Expect = 3e-08 Identities = 45/141 (31%), Positives = 67/141 (47%), Gaps = 4/141 (2%) Frame = +3 Query: 219 RFDERNVIGKGANGTVYKGTTKD-NELVAIKKCR---LASERQQKEFGKEMLIVSQINHR 386 R++ IG+G VYK N +VAIK R A E K+F +E + ++H Sbjct: 9 RYEILEKIGEGGMAKVYKAKCHLLNRIVAIKILRPEFAADENFVKKFKRESQAAASLSHP 68 Query: 387 YIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLH 566 IV +Y E ++ +V +Y+ TL LI R +G + + IA Q AL + H Sbjct: 69 NIVGIYDVGQEGDIYYIVMEYVKGRTLKELI--RENGGPLEVKRAVEIASQVCRALDHAH 126 Query: 567 SWASPPIIHGDVKTSNILLDE 629 IIH D+K NIL+ + Sbjct: 127 K---NKIIHRDIKPQNILVTD 144
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 57.4 bits (137), Expect = 3e-08 Identities = 39/132 (29%), Positives = 75/132 (56%), Gaps = 2/132 (1%) Frame = +3 Query: 234 NVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCC 413 N IG+G G+V++ + VA K + +S+ ++++F E I+ ++ HR IV+L G C Sbjct: 224 NEIGRGFFGSVHRAKWGRSYEVAAKMLQ-SSKAEREKFVLEAKIMHKLRHRKIVELLGVC 282 Query: 414 LE-VEVPML-VYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPI 587 E ++PML + +Y+ NG+L + DG + +++ + +E ++YL S + Sbjct: 283 TEPQDMPMLIIVEYMKNGSLKEYLK-TPDGKKTNLNQMVHMMAEISEGMAYLE---SEKV 338 Query: 588 IHGDVKTSNILL 623 +H D++ NIL+ Sbjct: 339 VHRDLRADNILV 350
>MET_PONPY (Q2IBD8) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 57.4 bits (137), Expect = 3e-08 Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNE----LVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G VY GT DN+ A+K R+ + +F E +I+ +H ++ L Sbjct: 1083 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL E P++V Y+ +G L I P + + Q A+ + YL AS Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---AS 1197 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 1198 KKFVHRDLAARNCMLDE 1214
>MET_PIG (Q2QLE0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 57.4 bits (137), Expect = 3e-08 Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNE----LVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G VY GT DN+ A+K R+ + +F E +I+ +H ++ L Sbjct: 1083 VIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL E P++V Y+ +G L I P + + Q A+ + YL AS Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---AS 1197 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 1198 KKFVHRDLAARNCMLDE 1214
>MET_PANTR (Q2QLF1) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 57.4 bits (137), Expect = 3e-08 Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNE----LVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G VY GT DN+ A+K R+ + +F E +I+ +H ++ L Sbjct: 1083 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL E P++V Y+ +G L I P + + Q A+ + YL AS Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---AS 1197 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 1198 KKFVHRDLAARNCMLDE 1214
>MET_HUMAN (P08581) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 57.4 bits (137), Expect = 3e-08 Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNE----LVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G VY GT DN+ A+K R+ + +F E +I+ +H ++ L Sbjct: 1083 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL E P++V Y+ +G L I P + + Q A+ + YL AS Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---AS 1197 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 1198 KKFVHRDLAARNCMLDE 1214
>MET_HORSE (Q2QLA9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 57.4 bits (137), Expect = 3e-08 Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNE----LVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G VY GT DN+ A+K R+ + +F E +I+ +H ++ L Sbjct: 1083 VIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL E P++V Y+ +G L I P + + Q A+ + YL AS Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---AS 1197 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 1198 KKFVHRDLAARNCMLDE 1214
>MET_CALMO (Q2QLC0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 57.4 bits (137), Expect = 3e-08 Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNE----LVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G VY GT DN+ A+K R+ + +F E +I+ +H ++ L Sbjct: 1083 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL E P++V Y+ +G L I P + + Q A+ + YL AS Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---AS 1197 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 1198 KKFVHRDLAARNCMLDE 1214
>MET_CALJA (Q2QLG5) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 57.4 bits (137), Expect = 3e-08 Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNE----LVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G VY GT DN+ A+K R+ + +F E +I+ +H ++ L Sbjct: 1083 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 1142 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL E P++V Y+ +G L I P + + Q A+ + YL AS Sbjct: 1143 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---AS 1197 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 1198 KKFVHRDLAARNCMLDE 1214
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 57.4 bits (137), Expect = 3e-08 Identities = 51/194 (26%), Positives = 84/194 (43%), Gaps = 9/194 (4%) Frame = +3 Query: 69 YMIYAKRRLAKIKR---EYFEQHGGLTLFDEMRSRQGLSFKLFTQEELEEATGRFDERNV 239 + +Y +R+ K KR + E L + ++ + EL+ V Sbjct: 671 FAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRV-------KV 723 Query: 240 IGKGANGTVYKGT-TKDNELVAIKKC-----RLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G GA GTVYKG + E V I + EF E LI++ ++H ++V+L Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRL 783 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASP 581 G CL + LV + +P+G L +H +D I LN Q A+ + YL Sbjct: 784 LGVCLSPTI-QLVTQLMPHGCLLEYVHEHKD--NIGSQLLLNWCVQIAKGMMYLE---ER 837 Query: 582 PIIHGDVKTSNILL 623 ++H D+ N+L+ Sbjct: 838 RLVHRDLAARNVLV 851
>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) Length = 698 Score = 57.4 bits (137), Expect = 3e-08 Identities = 40/140 (28%), Positives = 70/140 (50%), Gaps = 3/140 (2%) Frame = +3 Query: 219 RFDERNVIGKGANGTVYKGTTK-DNELVAIKKCRLA--SERQQKEFGKEMLIVSQINHRY 389 +++ V+G+GA G V+ K D +LV +K+ + ++ +++ E ++ +NH Sbjct: 3 KYERIRVVGRGAFGIVHLCLRKADQKLVILKQIPVEQMTKEERQAAQNECQVLKLLNHPN 62 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHS 569 +++ Y LE + M+ +Y P GTL I R + I H + L LH Sbjct: 63 VIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNS----LLEEETILHFFVQILLALHH 118 Query: 570 WASPPIIHGDVKTSNILLDE 629 + I+H D+KT NILLD+ Sbjct: 119 VHTHLILHRDLKTQNILLDK 138
>ATG1_SCHPO (Q9Y7T4) Serine/threonine-protein kinase atg1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 830 Score = 57.0 bits (136), Expect = 5e-08 Identities = 48/165 (29%), Positives = 74/165 (44%), Gaps = 21/165 (12%) Frame = +3 Query: 192 QEELEEATGRFDERNVIGKGANGTVYKGT-TKDNELVAIKKC--RLASERQQKEFGKEML 362 Q + G + R+ IG+G+ VYKG T+ N +++IK + +++ + E+ Sbjct: 4 QTSTNQTIGPYVIRSEIGRGSFAIVYKGKHTETNRVISIKSVLTKKLTKKLLENLESEIS 63 Query: 363 IVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAH-- 536 I+ +I H ++V+L C LV +Y G L I R IP A +NI H Sbjct: 64 ILKEIRHVHVVELIDCIKAGRFIHLVMEYCSLGDLSYFIRKREKFNSIPSLAWINIDHPP 123 Query: 537 ----------------QTAEALSYLHSWASPPIIHGDVKTSNILL 623 Q A AL +L S + +IH DVK N+LL Sbjct: 124 VYKAGLNETLVRHFTQQLASALQFLRSRS---LIHRDVKPQNLLL 165
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 57.0 bits (136), Expect = 5e-08 Identities = 41/147 (27%), Positives = 73/147 (49%), Gaps = 19/147 (12%) Frame = +3 Query: 240 IGKGANGTVYKGT------TKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKL 401 +G+GA G V+ TK LVA+K + + +K+F +E +++ + H +IVK Sbjct: 544 LGEGAFGKVFLAECYNLSPTKVKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 603 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLI--HG-----------RRDGPRIPFTARLNIAHQT 542 YG C + + ++V++Y+ +G L + + HG R+ + + L+IA Q Sbjct: 604 YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQI 663 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILL 623 + YL AS +H D+ T N L+ Sbjct: 664 CSGMVYL---ASQHFVHRDLATRNCLV 687
>TAOK3_CHICK (Q9I9E0) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Kinase from chicken) Length = 898 Score = 57.0 bits (136), Expect = 5e-08 Identities = 46/153 (30%), Positives = 72/153 (47%), Gaps = 4/153 (2%) Frame = +3 Query: 183 LFTQEELEEATGRFDERNVIGKGANGTVYKGTTKD-NELVAIKKCRLASERQQKEFG--- 350 LF +++ EE F + IG G+ G VY T NE+VA+KK + ++ +++ Sbjct: 14 LFYKDDPEEI---FVGLHEIGHGSFGAVYFATNSHTNEVVAVKKMSYSGKQTNEKWQDII 70 Query: 351 KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNI 530 KE+ + Q+ H ++ GC L+ LV +Y L ++ + A I Sbjct: 71 KEVKFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDMLEVHKKPLQEVEIAA---I 127 Query: 531 AHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 H + L+YLHS IH D+K NILL E Sbjct: 128 THGALQGLAYLHSHCK---IHRDIKAGNILLTE 157
>SULU_CAEEL (P46549) Serine/threonine-protein kinase SULU (EC 2.7.11.1)| (Protein kinase 18) Length = 982 Score = 57.0 bits (136), Expect = 5e-08 Identities = 50/153 (32%), Positives = 76/153 (49%), Gaps = 4/153 (2%) Frame = +3 Query: 183 LFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNE-LVAIKKCRLASERQQKEFG--- 350 LF+ ++ E+ R+ + IG G+ G VY K NE VAIKK + ++ +++ Sbjct: 20 LFSNKDPEQ---RYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKWNDIL 76 Query: 351 KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNI 530 KE+ ++ + H +IV C L+ LV +Y G+ ++ R G R A I Sbjct: 77 KEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYCI-GSAADIVDVLRKGMREVEIAA--I 133 Query: 531 AHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 QT +AL YLHS IH D+K NILL + Sbjct: 134 CSQTLDALRYLHSLKR---IHRDIKAGNILLSD 163
>STK24_MOUSE (Q99KH8) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| Length = 431 Score = 56.6 bits (135), Expect = 6e-08 Identities = 43/139 (30%), Positives = 72/139 (51%), Gaps = 3/139 (2%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGT-TKDNELVAIKKCRLA-SERQQKEFGKEMLIVSQINHRYIV 395 F + IGKG+ G V+KG + ++VAIK L +E + ++ +E+ ++SQ + Y+ Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 83 Query: 396 KLYGCCLEVEVPMLVYKYIPNGTLYRLIH-GRRDGPRIPFTARLNIAHQTAEALSYLHSW 572 K YG L+ ++ +Y+ G+ L+ G D +I I + + L YLHS Sbjct: 84 KYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDEIQIA-----TILREILKGLDYLHSE 138 Query: 573 ASPPIIHGDVKTSNILLDE 629 IH D+K +N+LL E Sbjct: 139 KK---IHRDIKAANVLLSE 154
>KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC 2.7.11.11) (PKA| 3) Length = 398 Score = 56.6 bits (135), Expect = 6e-08 Identities = 41/139 (29%), Positives = 65/139 (46%) Frame = +3 Query: 213 TGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYI 392 TG F ++I NG Y L +KK + +Q + E ++S ++H +I Sbjct: 96 TGSFGRVHLIRSNHNGRFYA-------LKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFI 148 Query: 393 VKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSW 572 ++++G + + +V YI G L+ L+ R R P A + AL YLH Sbjct: 149 IRMWGTFQDSQQVFMVMDYIEGGELFSLL---RKSQRFPNPVAKFYAAEVCLALEYLH-- 203 Query: 573 ASPPIIHGDVKTSNILLDE 629 S II+ D+K NILLD+ Sbjct: 204 -SKDIIYRDLKPENILLDK 221
>TAOK3_MOUSE (Q8BYC6) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) Length = 898 Score = 56.6 bits (135), Expect = 6e-08 Identities = 45/153 (29%), Positives = 74/153 (48%), Gaps = 4/153 (2%) Frame = +3 Query: 183 LFTQEELEEATGRFDERNVIGKGANGTVYKGTTKD-NELVAIKKCRLASERQQKEFG--- 350 LF +++ EE F + + IG G+ G VY T NE+VA+KK + ++ +++ Sbjct: 14 LFFKDDPEEL---FIDLHEIGHGSFGAVYFATNAHTNEVVAVKKMSYSGKQTHEKWQDIL 70 Query: 351 KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNI 530 KE+ + Q+ H ++ GC L+ LV +Y L ++ + A I Sbjct: 71 KEVKFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA---I 127 Query: 531 AHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 H + L+YLH + +IH D+K NILL E Sbjct: 128 THGALQGLAYLHFHS---LIHRDIKAGNILLTE 157
>WIS4_SCHPO (O14299) MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase| kinase kinase wak1) (MAP kinase kinase kinase wik1) Length = 1401 Score = 56.6 bits (135), Expect = 6e-08 Identities = 41/144 (28%), Positives = 74/144 (51%), Gaps = 6/144 (4%) Frame = +3 Query: 213 TGRFDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQK----EFGKEMLIVSQI 377 T R+ + + + G G VY G + +L+A+K+ +L R + + EM ++ ++ Sbjct: 1034 TIRWQQGHFVRSGMFGDVYTGVNMETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERL 1093 Query: 378 NHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLI-HGRRDGPRIPFTARLNIAHQTAEAL 554 NH +V YG + E + ++ G+L L+ HGR + + ++ + Q E L Sbjct: 1094 NHPNVVTYYGVEVHREKVYIFMEFCQGGSLADLLAHGRIEDENV---LKVYVV-QLLEGL 1149 Query: 555 SYLHSWASPPIIHGDVKTSNILLD 626 +Y+H S I+H D+K +NILLD Sbjct: 1150 AYIH---SQHILHRDIKPANILLD 1170
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 56.2 bits (134), Expect = 8e-08 Identities = 40/132 (30%), Positives = 61/132 (46%), Gaps = 2/132 (1%) Frame = +3 Query: 240 IGKGANGTVYKGTTK-DNELVAIKKCRLASERQQK-EFGKEMLIVSQINHRYIVKLYGCC 413 IG+G G V+ G + DN VA+K CR + K +F +E I+ Q NH IV+L G C Sbjct: 278 IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQYNHPNIVRLIGVC 337 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + +V + + G + R GP + + + A + YL S IH Sbjct: 338 TQKQPIYIVMELVQGGDFLSFL--RSKGPHLKMKELIKMMENAAAGMEYLE---SKHCIH 392 Query: 594 GDVKTSNILLDE 629 D+ N L+ E Sbjct: 393 RDLAARNCLVTE 404
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 56.2 bits (134), Expect = 8e-08 Identities = 41/132 (31%), Positives = 62/132 (46%), Gaps = 2/132 (1%) Frame = +3 Query: 240 IGKGANGTVYKGTTK-DNELVAIKKCRLASERQQK-EFGKEMLIVSQINHRYIVKLYGCC 413 IG+G G V+ G + DN LVA+K CR K +F +E I+ Q +H IV+L G C Sbjct: 222 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVC 281 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + +V + + G + R +G R+ L + A + YL S IH Sbjct: 282 TQKQPIYIVMELVQGGDFLTFL--RTEGARLRMKTLLQMVGDAAAGMEYLESKC---CIH 336 Query: 594 GDVKTSNILLDE 629 D+ N L+ E Sbjct: 337 RDLAARNCLVTE 348
>FES_FSVGA (P00542) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 609 Score = 56.2 bits (134), Expect = 8e-08 Identities = 41/132 (31%), Positives = 62/132 (46%), Gaps = 2/132 (1%) Frame = +3 Query: 240 IGKGANGTVYKGTTK-DNELVAIKKCRLASERQQK-EFGKEMLIVSQINHRYIVKLYGCC 413 IG+G G V+ G + DN LVA+K CR K +F +E I+ Q +H IV+L G C Sbjct: 354 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVC 413 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + +V + + G + R +G R+ L + A + YL S IH Sbjct: 414 TQKQPIYIVMELVQGGDFLTFL--RTEGARLRMKTLLQMVGDAAAGMEYLESKC---CIH 468 Query: 594 GDVKTSNILLDE 629 D+ N L+ E Sbjct: 469 RDLAARNCLVTE 480
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 56.2 bits (134), Expect = 8e-08 Identities = 45/150 (30%), Positives = 68/150 (45%), Gaps = 1/150 (0%) Frame = +3 Query: 177 FKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKE 356 +KL Q+ E E +G GA G V+ G + E VAIKK R +E K K Sbjct: 153 YKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE-VAIKKVREQNETDIKHLRK- 210 Query: 357 MLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIH-GRRDGPRIPFTARLNIA 533 + H I+ G C + ++ +Y +G LY ++ GR+ PR+ I Sbjct: 211 ------LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGI- 263 Query: 534 HQTAEALSYLHSWASPPIIHGDVKTSNILL 623 A ++YLH IIH D+K+ N+L+ Sbjct: 264 ---ASGMNYLH---LHKIIHRDLKSPNVLV 287
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 56.2 bits (134), Expect = 8e-08 Identities = 45/150 (30%), Positives = 68/150 (45%), Gaps = 1/150 (0%) Frame = +3 Query: 177 FKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKE 356 +KL Q+ E E +G GA G V+ G + E VAIKK R +E K K Sbjct: 153 YKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE-VAIKKVREQNETDIKHLRK- 210 Query: 357 MLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIH-GRRDGPRIPFTARLNIA 533 + H I+ G C + ++ +Y +G LY ++ GR+ PR+ I Sbjct: 211 ------LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGI- 263 Query: 534 HQTAEALSYLHSWASPPIIHGDVKTSNILL 623 A ++YLH IIH D+K+ N+L+ Sbjct: 264 ---ASGMNYLH---LHKIIHRDLKSPNVLV 287
>FES_HUMAN (P07332) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 822 Score = 56.2 bits (134), Expect = 8e-08 Identities = 41/132 (31%), Positives = 62/132 (46%), Gaps = 2/132 (1%) Frame = +3 Query: 240 IGKGANGTVYKGTTK-DNELVAIKKCRLASERQQK-EFGKEMLIVSQINHRYIVKLYGCC 413 IG+G G V+ G + DN LVA+K CR K +F +E I+ Q +H IV+L G C Sbjct: 567 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVC 626 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + +V + + G + R +G R+ L + A + YL S IH Sbjct: 627 TQKQPIYIVMELVQGGDFLTFL--RTEGARLRVKTLLQMVGDAAAGMEYLESKC---CIH 681 Query: 594 GDVKTSNILLDE 629 D+ N L+ E Sbjct: 682 RDLAARNCLVTE 693
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 56.2 bits (134), Expect = 8e-08 Identities = 38/138 (27%), Positives = 68/138 (49%), Gaps = 4/138 (2%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDNE-LVAIK---KCRLASERQQKEFGKEMLIVSQINHRY 389 F+ +GKG G VY K++ +VA+K K ++ E + + +E+ I + + H Sbjct: 43 FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN 102 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHS 569 I++LY + L+ +Y P G LY+ + + ++ I + A+AL+Y H Sbjct: 103 ILRLYNYFHDARRVYLILEYAPRGELYKEL---QKSEKLDEQRTATIIEELADALTYCH- 158 Query: 570 WASPPIIHGDVKTSNILL 623 +IH D+K N+LL Sbjct: 159 --DKKVIHRDIKPENLLL 174
>TAOK1_RAT (O88664) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 56.2 bits (134), Expect = 8e-08 Identities = 46/154 (29%), Positives = 73/154 (47%), Gaps = 4/154 (2%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKGT-TKDNELVAIKKCRLASERQQKEFG-- 350 +LF +E+ E+ F + IG G+ G VY + NE+VAIKK + ++ +++ Sbjct: 17 ELFFKEDPEKL---FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDI 73 Query: 351 -KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLN 527 KE+ + +I H ++ GC L LV +Y L ++ + A Sbjct: 74 IKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA--- 130 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 I H + L+YLHS +IH D+K NILL E Sbjct: 131 ITHGALQGLAYLHSHT---MIHRDIKAGNILLTE 161
>TAOK1_MOUSE (Q5F2E8) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) Length = 1001 Score = 56.2 bits (134), Expect = 8e-08 Identities = 46/154 (29%), Positives = 73/154 (47%), Gaps = 4/154 (2%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKGT-TKDNELVAIKKCRLASERQQKEFG-- 350 +LF +E+ E+ F + IG G+ G VY + NE+VAIKK + ++ +++ Sbjct: 17 ELFFKEDPEKL---FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDI 73 Query: 351 -KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLN 527 KE+ + +I H ++ GC L LV +Y L ++ + A Sbjct: 74 IKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA--- 130 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 I H + L+YLHS +IH D+K NILL E Sbjct: 131 ITHGALQGLAYLHSHT---MIHRDIKAGNILLTE 161
>TAOK1_HUMAN (Q7L7X3) Serine/threonine-protein kinase TAO1 (EC 2.7.11.1)| (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B) Length = 1001 Score = 56.2 bits (134), Expect = 8e-08 Identities = 46/154 (29%), Positives = 73/154 (47%), Gaps = 4/154 (2%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKGT-TKDNELVAIKKCRLASERQQKEFG-- 350 +LF +E+ E+ F + IG G+ G VY + NE+VAIKK + ++ +++ Sbjct: 17 ELFFKEDPEKL---FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDI 73 Query: 351 -KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLN 527 KE+ + +I H ++ GC L LV +Y L ++ + A Sbjct: 74 IKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA--- 130 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 I H + L+YLHS +IH D+K NILL E Sbjct: 131 ITHGALQGLAYLHSHT---MIHRDIKAGNILLTE 161
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC| 2.7.10.2) (C-FES) Length = 820 Score = 56.2 bits (134), Expect = 8e-08 Identities = 41/132 (31%), Positives = 62/132 (46%), Gaps = 2/132 (1%) Frame = +3 Query: 240 IGKGANGTVYKGTTK-DNELVAIKKCRLASERQQK-EFGKEMLIVSQINHRYIVKLYGCC 413 IG+G G V+ G + DN LVA+K CR K +F +E I+ Q +H IV+L G C Sbjct: 565 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVC 624 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + +V + + G + R +G R+ L + A + YL S IH Sbjct: 625 TQKQPIYIVMELVQGGDFLTFL--RTEGARLRMKTLLQMVGDAAAGMEYLESKC---CIH 679 Query: 594 GDVKTSNILLDE 629 D+ N L+ E Sbjct: 680 RDLAARNCLVTE 691
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 55.8 bits (133), Expect = 1e-07 Identities = 40/138 (28%), Positives = 68/138 (49%), Gaps = 4/138 (2%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDNELV----AIKKCRLASERQQKEFGKEMLIVSQINHRY 389 F+ V+GKG G VY ++ V A++K + +K+F +E+ I S + H Sbjct: 109 FEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQFRREVEIQSSLRHPN 168 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHS 569 + +LYG + + L+ +Y+ NG LY+ + GR +Q A+AL Y+H Sbjct: 169 LTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGR---SHFNDVVASYYVYQMADALDYMH- 224 Query: 570 WASPPIIHGDVKTSNILL 623 I+H D+K NI++ Sbjct: 225 --ERNILHRDIKPENIII 240
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 55.8 bits (133), Expect = 1e-07 Identities = 38/132 (28%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCC 413 V+GKG G K T ++ E++ +K+ E Q+ F KE+ ++ + H ++K G Sbjct: 344 VLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVL 403 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + + +YI GTL +I + + P++ R++ A A ++YLHS IIH Sbjct: 404 YKDKRLNFITEYIKGGTLRGII--KNMDSQYPWSQRVSFAKDIASGMAYLHSM---NIIH 458 Query: 594 GDVKTSNILLDE 629 D+ + N L+ E Sbjct: 459 RDLNSHNCLVRE 470
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 55.8 bits (133), Expect = 1e-07 Identities = 45/158 (28%), Positives = 78/158 (49%), Gaps = 9/158 (5%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIK---KCRLASERQQKEFG 350 +L + E E + IGKG G V +G ++ + VAIK + + ++ F Sbjct: 1275 QLPVRSEYEIDFNELEFGQTIGKGFFGEVKRGYWRETD-VAIKIIYRDQFKTKSSLVMFQ 1333 Query: 351 KEMLIVSQINHRYIVKLYGCCLE--VEVPMLVYKYIPNGTLYRLIHGR----RDGPRIPF 512 E+ I+S++ H +V+ G C + +V +++ G+L + + P I Sbjct: 1334 NEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPHI-- 1391 Query: 513 TARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 RL +A A+ ++YLH W +PPI+H D+ + NILLD Sbjct: 1392 --RLKLALDIAKGMNYLHGW-TPPILHRDLSSRNILLD 1426
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 55.8 bits (133), Expect = 1e-07 Identities = 39/130 (30%), Positives = 66/130 (50%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 IG G+ GTVYKG + V I K + Q + F E+ ++ + H I+ G + Sbjct: 355 IGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTK 414 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 + +V ++ +LY+ +H + + ++IA QTA+ + YLH + IIH D Sbjct: 415 DNL-AIVTQWCEGSSLYKHLHVQE--TKFQMFQLIDIARQTAQGMDYLH---AKNIIHRD 468 Query: 600 VKTSNILLDE 629 +K++NI L E Sbjct: 469 MKSNNIFLHE 478
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 55.8 bits (133), Expect = 1e-07 Identities = 39/130 (30%), Positives = 66/130 (50%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 IG G+ GTVYKG + V I K + Q + F E+ ++ + H I+ G + Sbjct: 355 IGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTK 414 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 + +V ++ +LY+ +H + + ++IA QTA+ + YLH + IIH D Sbjct: 415 DNL-AIVTQWCEGSSLYKHLHVQE--TKFQMFQLIDIARQTAQGMDYLH---AKNIIHRD 468 Query: 600 VKTSNILLDE 629 +K++NI L E Sbjct: 469 MKSNNIFLHE 478
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 55.8 bits (133), Expect = 1e-07 Identities = 44/140 (31%), Positives = 67/140 (47%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDNELV-AIK---KCRLASERQQKEFGKEMLIVSQINHRY 389 FD +GKG G VY K ++ + A+K K +L + + +E+ I S + H Sbjct: 126 FDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKVQLEKAGVEHQLRREVEIQSHLRHPN 185 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIH--GRRDGPRIPFTARLNIAHQTAEALSYL 563 I++LYG + L+ +Y P GT+YR + + D R + A ALSY Sbjct: 186 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQR-----TATYITELANALSYC 240 Query: 564 HSWASPPIIHGDVKTSNILL 623 H S +IH D+K N+LL Sbjct: 241 H---SKRVIHRDIKPENLLL 257
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 55.8 bits (133), Expect = 1e-07 Identities = 39/132 (29%), Positives = 67/132 (50%), Gaps = 1/132 (0%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCC 413 V+GKG G K T ++ E++ +K+ E Q+ F KE+ ++ + H ++K G Sbjct: 351 VLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVL 410 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + + +YI GTL LI + P++ R++ A A ++YLHS IIH Sbjct: 411 YKEKRLNFITEYIKGGTLRGLI--KSMDSHYPWSQRVSFAKDIAAGMAYLHSM---NIIH 465 Query: 594 GDVKTSNILLDE 629 D+ + N L+ E Sbjct: 466 RDLNSHNCLVRE 477
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 55.8 bits (133), Expect = 1e-07 Identities = 39/130 (30%), Positives = 66/130 (50%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 IG G+ GTVYKG + V I K + Q + F E+ ++ + H I+ G + Sbjct: 30 IGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTK 89 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 + +V ++ +LY+ +H + + ++IA QTA+ + YLH + IIH D Sbjct: 90 DNL-AIVTQWCEGSSLYKHLHVQE--TKFQMFQLIDIARQTAQGMDYLH---AKNIIHRD 143 Query: 600 VKTSNILLDE 629 +K++NI L E Sbjct: 144 MKSNNIFLHE 153
>TAOK3_HUMAN (Q9H2K8) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1)| (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen H Length = 898 Score = 55.8 bits (133), Expect = 1e-07 Identities = 47/153 (30%), Positives = 73/153 (47%), Gaps = 4/153 (2%) Frame = +3 Query: 183 LFTQEELEEATGRFDERNVIGKGANGTVYKGTTKD-NELVAIKKCRLASERQQKEFG--- 350 LF +++ EE F + IG G+ G VY T +E+VAIKK + ++ +++ Sbjct: 14 LFYKDDPEEL---FIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDIL 70 Query: 351 KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNI 530 KE+ + Q+ H ++ GC L+ LV +Y L ++ + A I Sbjct: 71 KEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA---I 127 Query: 531 AHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 H L+YLHS A +IH D+K NILL E Sbjct: 128 THGALHGLAYLHSHA---LIHRDIKAGNILLTE 157
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 55.5 bits (132), Expect = 1e-07 Identities = 39/130 (30%), Positives = 66/130 (50%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 IG G+ GTVYKG + V I K + Q + F E+ ++ + H I+ G + Sbjct: 355 IGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTK 414 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 + +V ++ +LY+ +H + + ++IA QTA+ + YLH + IIH D Sbjct: 415 DNL-AIVTQWCEGSSLYKHLHVQE--TKFQMFQLIDIARQTAQGMDYLH---AKNIIHRD 468 Query: 600 VKTSNILLDE 629 +K++NI L E Sbjct: 469 MKSNNIFLHE 478
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 55.5 bits (132), Expect = 1e-07 Identities = 38/132 (28%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCC 413 V+GKG G K T ++ E++ +K+ E Q+ F KE+ ++ + H ++K G Sbjct: 344 VLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVL 403 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + + +YI GTL +I + + P++ R++ A A ++YLHS IIH Sbjct: 404 YKDKRLNFITEYIKGGTLRGII--KSMDSQYPWSQRVSFAKDIASGMAYLHSM---NIIH 458 Query: 594 GDVKTSNILLDE 629 D+ + N L+ E Sbjct: 459 RDLNSHNCLVRE 470
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 55.5 bits (132), Expect = 1e-07 Identities = 38/132 (28%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCC 413 V+GKG G K T ++ E++ +K+ E Q+ F KE+ ++ + H ++K G Sbjct: 344 VLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVL 403 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + + +YI GTL +I + + P++ R++ A A ++YLHS IIH Sbjct: 404 YKDKRLNFITEYIKGGTLRGII--KSMDSQYPWSQRVSFAKDIASGMAYLHSM---NIIH 458 Query: 594 GDVKTSNILLDE 629 D+ + N L+ E Sbjct: 459 RDLNSHNCLVRE 470
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 55.5 bits (132), Expect = 1e-07 Identities = 49/165 (29%), Positives = 77/165 (46%), Gaps = 6/165 (3%) Frame = +3 Query: 147 DEMRSRQGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELV-AIK---KC 314 +E+ S+Q Q LE+ F+ +GKG G VY K ++ + A+K K Sbjct: 112 EELASKQKNEESKKRQWALED----FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA 167 Query: 315 RLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIH--GR 488 +L + + +E+ I S + H I++LYG + L+ +Y P GT+YR + + Sbjct: 168 QLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK 227 Query: 489 RDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILL 623 D R + A ALSY H S +IH D+K N+LL Sbjct: 228 FDEQR-----TATYITELANALSYCH---SKRVIHRDIKPENLLL 264
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 55.5 bits (132), Expect = 1e-07 Identities = 39/130 (30%), Positives = 66/130 (50%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 IG G+ GTVYKG + V I K + Q + F E+ ++ + H I+ G + Sbjct: 355 IGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTK 414 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 + +V ++ +LY+ +H + + ++IA QTA+ + YLH + IIH D Sbjct: 415 DNL-AIVTQWCEGSSLYKHLHVQE--TKFQMFQLIDIARQTAQGMDYLH---AKNIIHRD 468 Query: 600 VKTSNILLDE 629 +K++NI L E Sbjct: 469 MKSNNIFLHE 478
>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.11.1)| (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2) Length = 487 Score = 55.5 bits (132), Expect = 1e-07 Identities = 43/136 (31%), Positives = 68/136 (50%), Gaps = 1/136 (0%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVK 398 FD +G+G+ G+VYK K+ ++VAIK+ + S+ Q E KE+ I+ Q + ++VK Sbjct: 30 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQ--EIIKEISIMQQCDSPHVVK 87 Query: 399 LYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 YG + +V +Y G++ +I R + I T + L YLH Sbjct: 88 YYGSYFKNTDLWIVMEYCGAGSVSDII--RLRNKTLTEDEIATILQSTLKGLEYLHFMRK 145 Query: 579 PPIIHGDVKTSNILLD 626 IH D+K NILL+ Sbjct: 146 ---IHRDIKAGNILLN 158
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 55.5 bits (132), Expect = 1e-07 Identities = 43/140 (30%), Positives = 67/140 (47%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDNELV-AIK---KCRLASERQQKEFGKEMLIVSQINHRY 389 FD +GKG G VY + ++ + A+K K +L + + +E+ I S + H Sbjct: 124 FDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHPN 183 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIH--GRRDGPRIPFTARLNIAHQTAEALSYL 563 I++LYG + L+ +Y P GT+YR + + D R + A ALSY Sbjct: 184 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQR-----TATYITELANALSYC 238 Query: 564 HSWASPPIIHGDVKTSNILL 623 H S +IH D+K N+LL Sbjct: 239 H---SKRVIHRDIKPENLLL 255
>STK3_MOUSE (Q9JI10) Serine/threonine-protein kinase 3 (EC 2.7.11.1)| (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) Length = 497 Score = 55.5 bits (132), Expect = 1e-07 Identities = 43/136 (31%), Positives = 69/136 (50%), Gaps = 1/136 (0%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVK 398 FD +G+G+ G+V+K K++ ++VAIK+ + S+ Q E KE+ I+ Q + Y+VK Sbjct: 27 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ--EIIKEISIMQQCDSPYVVK 84 Query: 399 LYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 YG + +V +Y G++ +I R + I T + L YLH Sbjct: 85 YYGSYFKNTDLWIVMEYCGAGSVSDII--RLRNKTLTEDEIATILKSTLKGLEYLHFMRK 142 Query: 579 PPIIHGDVKTSNILLD 626 IH D+K NILL+ Sbjct: 143 ---IHRDIKAGNILLN 155
>STK10_HUMAN (O94804) Serine/threonine-protein kinase 10 (EC 2.7.11.1)| (Lymphocyte-oriented kinase) Length = 968 Score = 55.1 bits (131), Expect = 2e-07 Identities = 42/132 (31%), Positives = 65/132 (49%), Gaps = 4/132 (3%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCL 416 +G GA G VYK K+ L A K SE + +++ E+ I++ +H YIVKL G Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYY 101 Query: 417 EVEVPMLVYKYIPNGTLYRLIHGRRDG---PRIPFTARLNIAHQTAEALSYLHSWASPPI 587 ++ ++ P G + ++ G P+I R Q EAL++LH S I Sbjct: 102 HDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCR-----QMLEALNFLH---SKRI 153 Query: 588 IHGDVKTSNILL 623 IH D+K N+L+ Sbjct: 154 IHRDLKAGNVLM 165
>KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC 2.7.11.11) (PKA| 1) (CDC25-suppressing protein kinase) (PK-25) Length = 397 Score = 55.1 bits (131), Expect = 2e-07 Identities = 41/139 (29%), Positives = 63/139 (45%) Frame = +3 Query: 213 TGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYI 392 TG F ++I NG Y E+V K Q + E L++S + H +I Sbjct: 95 TGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLK-------QVEHTNDERLMLSIVTHPFI 147 Query: 393 VKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSW 572 ++++G + + ++ YI G L+ L+ R R P A + AL YLHS Sbjct: 148 IRMWGTFQDAQQIFMIMDYIEGGELFSLL---RKSQRFPNPVAKFYAAEVCLALEYLHS- 203 Query: 573 ASPPIIHGDVKTSNILLDE 629 II+ D+K NILLD+ Sbjct: 204 --KDIIYRDLKPENILLDK 220
>IPL1_DEBHA (Q6BVA0) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 412 Score = 55.1 bits (131), Expect = 2e-07 Identities = 44/138 (31%), Positives = 66/138 (47%), Gaps = 4/138 (2%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASE----RQQKEFGKEMLIVSQINHRY 389 F+ V+GKG G VY K + +A K + + +K F +E+ I S + H Sbjct: 148 FEIGKVLGKGKLGKVYCVKHKTSGYIAALKVMAKKDLIDLKLEKNFRREIEIQSNLIHPK 207 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHS 569 I +LYG + + L+ +Y +G LY + +R R + +Q A AL YLH+ Sbjct: 208 ISRLYGFFYDHKNVYLILEYSIHGELYHHLKVQR---RFNDATASHYIYQVALALDYLHT 264 Query: 570 WASPPIIHGDVKTSNILL 623 IIH D+K NILL Sbjct: 265 ---KHIIHRDIKPENILL 279
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 55.1 bits (131), Expect = 2e-07 Identities = 45/150 (30%), Positives = 74/150 (49%), Gaps = 21/150 (14%) Frame = +3 Query: 237 VIGKGANGTVYKGTT----KDNE--LVAIKKCR-LASERQQKEFGKEMLIVSQINHRYIV 395 VIG+GA G V+ GT + NE +VA+K + S+ +++F +E +++ I H IV Sbjct: 509 VIGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGSCSDSLKRDFEREAEMLATIEHANIV 568 Query: 396 KLYGCCLEVEVPMLVYKYIPNGTL--YRLIHG------------RRDGPRIPFTARLNIA 533 YG C E + M++++++ NG L Y +HG D ++ + I Sbjct: 569 TFYGVCTESDQWMMIFEFMENGDLNKYLRMHGPDAAFLKDRDSMDSDEGQLTREQLMKIV 628 Query: 534 HQTAEALSYLHSWASPPIIHGDVKTSNILL 623 Q A A+ YL A +H D+ T N L+ Sbjct: 629 LQIASAMEYL---ALQHFVHRDLATRNCLV 655
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 820 Score = 55.1 bits (131), Expect = 2e-07 Identities = 41/132 (31%), Positives = 61/132 (46%), Gaps = 2/132 (1%) Frame = +3 Query: 240 IGKGANGTVYKGTTK-DNELVAIKKCRLASERQQK-EFGKEMLIVSQINHRYIVKLYGCC 413 IG+G G V+ G + DN VA+K CR K +F +E I+ Q NH IV+L G C Sbjct: 565 IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVC 624 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + +V + + G + R +G R+ L + A + YL S IH Sbjct: 625 TQKQPIYIVMELVQGGDFLTFL--RTEGARLRVKTLLQMMGDAAAGMEYLESKC---CIH 679 Query: 594 GDVKTSNILLDE 629 D+ N L+ E Sbjct: 680 RDLAARNCLVTE 691
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 54.7 bits (130), Expect = 2e-07 Identities = 42/160 (26%), Positives = 76/160 (47%) Frame = +3 Query: 150 EMRSRQGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASE 329 E R+R + + ++ E G+ IG G+ GTVYKG + V + + Sbjct: 59 EDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP 118 Query: 330 RQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIP 509 +Q + F E+ ++ + H I+ G + ++ +V ++ +LY +H + Sbjct: 119 QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQL-AIVTQWCEGSSLYHHLHIIE--TKFE 175 Query: 510 FTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 ++IA QTA+ + YLH + IIH D+K++NI L E Sbjct: 176 MIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHE 212
>MET_RAT (P97523) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 54.7 bits (130), Expect = 2e-07 Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKDNE----LVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G VY GT D++ A+K R+ + +F E +I+ +H ++ L Sbjct: 1084 VIGRGHFGCVYHGTLLDSDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSL 1143 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL E P++V Y+ +G L I P + + Q A+ + YL S Sbjct: 1144 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTV--KDLIGFGLQVAKGMKYL---VS 1198 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 1199 KKFVHRDLAARNCMLDE 1215
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 54.7 bits (130), Expect = 2e-07 Identities = 42/160 (26%), Positives = 76/160 (47%) Frame = +3 Query: 150 EMRSRQGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASE 329 E R+R + + ++ E G+ IG G+ GTVYKG + V + + Sbjct: 43 EDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP 102 Query: 330 RQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIP 509 +Q + F E+ ++ + H I+ G + ++ +V ++ +LY +H + Sbjct: 103 QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQL-AIVTQWCEGSSLYHHLHIIE--TKFE 159 Query: 510 FTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 ++IA QTA+ + YLH + IIH D+K++NI L E Sbjct: 160 MIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHE 196
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 54.7 bits (130), Expect = 2e-07 Identities = 42/160 (26%), Positives = 76/160 (47%) Frame = +3 Query: 150 EMRSRQGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASE 329 E R+R + + ++ E G+ IG G+ GTVYKG + V + + Sbjct: 433 EDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP 492 Query: 330 RQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIP 509 +Q + F E+ ++ + H I+ G + ++ +V ++ +LY +H + Sbjct: 493 QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQL-AIVTQWCEGSSLYHHLHIIE--TKFE 549 Query: 510 FTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 ++IA QTA+ + YLH + IIH D+K++NI L E Sbjct: 550 MIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHE 586
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 54.7 bits (130), Expect = 2e-07 Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQ----QKEFGKEMLIVSQINHRY 389 F+ +GKG G VY ++++ + K S+ + + + +E+ I S + H Sbjct: 140 FEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPN 199 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIH--GRRDGPRIPFTARLNIAHQTAEALSYL 563 I++LYG + L+ Y P G L+R + R D R + Q AEAL Y Sbjct: 200 ILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSAMYIK-----QLAEALLYC 254 Query: 564 HSWASPPIIHGDVKTSNILL 623 H S +IH D+K N+LL Sbjct: 255 H---SKKVIHRDIKPENLLL 271
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 54.7 bits (130), Expect = 2e-07 Identities = 42/160 (26%), Positives = 76/160 (47%) Frame = +3 Query: 150 EMRSRQGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASE 329 E R+R + + ++ E G+ IG G+ GTVYKG + V + + Sbjct: 473 EDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP 532 Query: 330 RQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIP 509 +Q + F E+ ++ + H I+ G + ++ +V ++ +LY +H + Sbjct: 533 QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQL-AIVTQWCEGSSLYHHLHIIE--TKFE 589 Query: 510 FTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 ++IA QTA+ + YLH + IIH D+K++NI L E Sbjct: 590 MIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHE 626
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 54.7 bits (130), Expect = 2e-07 Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQ----QKEFGKEMLIVSQINHRY 389 F+ +GKG G VY ++++ + K S+ + + + +E+ I S + H Sbjct: 140 FEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPN 199 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIH--GRRDGPRIPFTARLNIAHQTAEALSYL 563 I++LYG + L+ Y P G L+R + R D R + Q AEAL Y Sbjct: 200 ILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSALYIK-----QLAEALLYC 254 Query: 564 HSWASPPIIHGDVKTSNILL 623 H S +IH D+K N+LL Sbjct: 255 H---SKKVIHRDIKPENLLL 271
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 54.7 bits (130), Expect = 2e-07 Identities = 42/160 (26%), Positives = 76/160 (47%) Frame = +3 Query: 150 EMRSRQGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASE 329 E R+R + + ++ E G+ IG G+ GTVYKG + V + + Sbjct: 473 EDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP 532 Query: 330 RQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIP 509 +Q + F E+ ++ + H I+ G + ++ +V ++ +LY +H + Sbjct: 533 QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQL-AIVTQWCEGSSLYHHLHIIE--TKFE 589 Query: 510 FTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 ++IA QTA+ + YLH + IIH D+K++NI L E Sbjct: 590 MIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHE 626
>STK3_HUMAN (Q13188) Serine/threonine-protein kinase 3 (EC 2.7.11.1)| (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1) Length = 491 Score = 54.7 bits (130), Expect = 2e-07 Identities = 43/136 (31%), Positives = 69/136 (50%), Gaps = 1/136 (0%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVK 398 FD +G+G+ G+V+K K++ ++VAIK+ + S+ Q E KE+ I+ Q + Y+VK Sbjct: 27 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ--EIIKEISIMQQCDSPYVVK 84 Query: 399 LYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 YG + +V +Y G++ +I R + I T + L YLH Sbjct: 85 YYGSYFKNTDLWIVMEYCGAGSVSDII--RLRNKTLIEDEIATILKSTLKGLEYLHFMRK 142 Query: 579 PPIIHGDVKTSNILLD 626 IH D+K NILL+ Sbjct: 143 ---IHRDIKAGNILLN 155
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 54.3 bits (129), Expect = 3e-07 Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 2/129 (1%) Frame = +3 Query: 243 GKGANGTVY--KGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCL 416 G G+ G+VY K ++D E VA+KK + KE I+S ++HR I++ YG L Sbjct: 23 GGGSFGSVYRAKWISQDKE-VAVKKLL--------KIEKEAEILSVLSHRNIIQFYGVIL 73 Query: 417 EVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHG 596 E +V +Y G+LY I+ R + + A A+ + YLH A +IH Sbjct: 74 EPPNYGIVTEYASLGSLYDYINSNR-SEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHR 132 Query: 597 DVKTSNILL 623 D+K+ N+++ Sbjct: 133 DLKSRNVVI 141
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 54.3 bits (129), Expect = 3e-07 Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 2/129 (1%) Frame = +3 Query: 243 GKGANGTVY--KGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCL 416 G G+ G+VY K ++D E VA+KK + KE I+S ++HR I++ YG L Sbjct: 23 GGGSFGSVYRAKWISQDKE-VAVKKLL--------KIEKEAEILSVLSHRNIIQFYGVIL 73 Query: 417 EVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHG 596 E +V +Y G+LY I+ R + + A A+ + YLH A +IH Sbjct: 74 EPPNYGIVTEYASLGSLYDYINSNR-SEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHR 132 Query: 597 DVKTSNILL 623 D+K+ N+++ Sbjct: 133 DLKSRNVVI 141
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 54.3 bits (129), Expect = 3e-07 Identities = 38/130 (29%), Positives = 63/130 (48%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 +G G G V++G KD VAIK + Q+ E+ + ++ H++I+ LY Sbjct: 197 LGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSV 256 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 + ++ + + G+L L+ D +P + L+IA Q AE + YL S IH D Sbjct: 257 GDPVYIITELMAKGSLLELLRD-SDEKVLPVSELLDIAWQVAEGMCYLE---SQNYIHRD 312 Query: 600 VKTSNILLDE 629 + NIL+ E Sbjct: 313 LAARNILVGE 322
>ZAP70_MOUSE (P43404) Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa| zeta-associated protein) (Syk-related tyrosine kinase) Length = 618 Score = 54.3 bits (129), Expect = 3e-07 Identities = 40/132 (30%), Positives = 68/132 (51%), Gaps = 4/132 (3%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNEL---VAIKKCRLASERQQK-EFGKEMLIVSQINHRYIVKLYG 407 +G G G+V +G + + VAIK + +E+ K E +E I+ Q+++ YIV+L G Sbjct: 343 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIG 402 Query: 408 CCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPI 587 C + E MLV + G L++ + G+++ IP + + HQ A + YL Sbjct: 403 VC-QAEALMLVMEMAGGGPLHKFLLGKKE--EIPVSNVAELLHQVAMGMKYLE---EKNF 456 Query: 588 IHGDVKTSNILL 623 +H D+ N+LL Sbjct: 457 VHRDLAARNVLL 468
>TAOK2_MOUSE (Q6ZQ29) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1055 Score = 53.9 bits (128), Expect = 4e-07 Identities = 43/154 (27%), Positives = 74/154 (48%), Gaps = 4/154 (2%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKGT-TKDNELVAIKKCRLASERQQKEFG-- 350 +LF +++ E+ F + IG G+ G VY +++E+VAIKK + ++ +++ Sbjct: 17 ELFFKDDPEKL---FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDI 73 Query: 351 -KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLN 527 KE+ + ++ H ++ GC L LV +Y L ++ + A Sbjct: 74 IKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA--- 130 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 + H + L+YLHS +IH DVK NILL E Sbjct: 131 VTHGALQGLAYLHSHN---MIHRDVKAGNILLSE 161
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 53.9 bits (128), Expect = 4e-07 Identities = 38/128 (29%), Positives = 65/128 (50%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 IG G+ GTVYKG + V I K + Q + F E+ ++ + H I+ G + Sbjct: 88 IGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTK 147 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 + +V ++ +LY+ +H + + ++IA QTA+ + YLH + IIH D Sbjct: 148 DNL-AIVTQWCEGSSLYKHLHVQE--TKFQMFQLIDIARQTAQGMDYLH---AKNIIHRD 201 Query: 600 VKTSNILL 623 +K++NI L Sbjct: 202 MKSNNIFL 209
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 53.9 bits (128), Expect = 4e-07 Identities = 41/157 (26%), Positives = 72/157 (45%), Gaps = 4/157 (2%) Frame = +3 Query: 165 QGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNE-LVAIK---KCRLASER 332 QG + +Q + F+ +GKG G VY K + +VA+K K ++ E Sbjct: 63 QGSTASQGSQNKQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEG 122 Query: 333 QQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPF 512 + + +E+ I + + H I++LY + + L+ +Y P G LY+ + R Sbjct: 123 VEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSR---TFDE 179 Query: 513 TARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILL 623 I + ++AL+Y H +IH D+K N+LL Sbjct: 180 QRTATIMEELSDALTYCH---KKKVIHRDIKPENLLL 213
>TAOK2_RAT (Q9JLS3) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1235 Score = 53.9 bits (128), Expect = 4e-07 Identities = 43/154 (27%), Positives = 74/154 (48%), Gaps = 4/154 (2%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKGT-TKDNELVAIKKCRLASERQQKEFG-- 350 +LF +++ E+ F + IG G+ G VY +++E+VAIKK + ++ +++ Sbjct: 17 ELFFKDDPEKL---FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDI 73 Query: 351 -KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLN 527 KE+ + ++ H ++ GC L LV +Y L ++ + A Sbjct: 74 IKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA--- 130 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 + H + L+YLHS +IH DVK NILL E Sbjct: 131 VTHGALQGLAYLHSHN---MIHRDVKAGNILLSE 161
>TAOK2_HUMAN (Q9UL54) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C) Length = 1235 Score = 53.9 bits (128), Expect = 4e-07 Identities = 43/154 (27%), Positives = 74/154 (48%), Gaps = 4/154 (2%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKGT-TKDNELVAIKKCRLASERQQKEFG-- 350 +LF +++ E+ F + IG G+ G VY +++E+VAIKK + ++ +++ Sbjct: 17 ELFFKDDPEKL---FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDI 73 Query: 351 -KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLN 527 KE+ + ++ H ++ GC L LV +Y L ++ + A Sbjct: 74 IKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA--- 130 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 + H + L+YLHS +IH DVK NILL E Sbjct: 131 VTHGALQGLAYLHSHN---MIHRDVKAGNILLSE 161
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 53.9 bits (128), Expect = 4e-07 Identities = 43/157 (27%), Positives = 80/157 (50%), Gaps = 6/157 (3%) Frame = +3 Query: 174 SFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCR--LASERQQKEF 347 S +FT+++ EE E +++ G V++ K KC L E E Sbjct: 24 SLTVFTRDDFEE------EWHLVASGGFSKVFQARHKRWRTQYAIKCSPCLQKETTSSEV 77 Query: 348 G---KEMLIVSQINHRYIVKLYGCCLEVEVPM-LVYKYIPNGTLYRLIHGRRDGPRIPFT 515 +E + + +I ++IV +YG C + P+ +V +++ +G+L + + + + Sbjct: 78 TCLFEEAVKMEKIKFQHIVSIYGVCKQ---PLGIVMEFMASGSLEKTLPTHS----LCWP 130 Query: 516 ARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 +L I H+T+ A+++LHS PP++H D+K NILLD Sbjct: 131 LKLRIIHETSLAMNFLHS-IKPPLLHLDLKPGNILLD 166
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 53.9 bits (128), Expect = 4e-07 Identities = 48/144 (33%), Positives = 69/144 (47%), Gaps = 5/144 (3%) Frame = +3 Query: 207 EATGRFD--ERNVIGKGANGTVYKGTTKD-NELVAIKKC--RLASERQQKEFGKEMLIVS 371 E G+F+ +++IG GA V+KG ++ ++L KC + + Q GKE+ I+ Sbjct: 9 ETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILK 68 Query: 372 QINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEA 551 ++ H IV LY LV +Y G L +H R T RL + Q A A Sbjct: 69 ELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSED--TIRLFL-QQIAGA 125 Query: 552 LSYLHSWASPPIIHGDVKTSNILL 623 + LHS IIH D+K NILL Sbjct: 126 MRLLHSKG---IIHRDLKPQNILL 146
>XMRK_XIPMA (P13388) Melanoma receptor tyrosine-protein kinase precursor (EC| 2.7.10.1) Length = 1167 Score = 53.9 bits (128), Expect = 4e-07 Identities = 48/140 (34%), Positives = 71/140 (50%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGT-TKDNE----LVAIKKCRLA-SERQQKEFGKEMLIVSQINH 383 F + V+G GA GTVYKG D E VAIK R A S + +E E +++ ++H Sbjct: 710 FKKDRVLGSGAFGTVYKGLWNPDGENIRIPVAIKVLREATSPKVNQEVLDEAYVMASVDH 769 Query: 384 RYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYL 563 ++ +L G CL V LV + +P G L L + R+ RI LN Q A+ ++YL Sbjct: 770 PHVCRLLGICLTSAV-QLVTQLMPYGCL--LDYVRQHQERICGQWLLNWCVQIAKGMNYL 826 Query: 564 HSWASPPIIHGDVKTSNILL 623 ++H D+ N+LL Sbjct: 827 E---ERHLVHRDLAARNVLL 843
>TAO1B_XENLA (Q7ZYJ0) Serine/threonine-protein kinase TAO1-B (EC 2.7.11.1)| (Thousand and one amino acid protein 1-B) Length = 1001 Score = 53.9 bits (128), Expect = 4e-07 Identities = 45/154 (29%), Positives = 73/154 (47%), Gaps = 4/154 (2%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKG-TTKDNELVAIKKCRLASERQQKEFG-- 350 +LF +++ E+ F + IG G+ G VY + +E+VAIKK + ++ +++ Sbjct: 17 ELFFRDDPEKL---FSDLREIGHGSFGAVYFAHDARTSEVVAIKKMSYSGKQSNEKWQDI 73 Query: 351 -KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLN 527 KE+ + +I H ++ GC L LV +Y L ++ I A Sbjct: 74 IKEVKFLQRIQHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEIEIAA--- 130 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 I H + L+YLHS +IH D+K NILL E Sbjct: 131 ITHGALQGLAYLHSHN---LIHRDIKAGNILLTE 161
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 53.9 bits (128), Expect = 4e-07 Identities = 39/147 (26%), Positives = 71/147 (48%) Frame = +3 Query: 189 TQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIV 368 + ++ E G+ IG G+ GTVYKG + V + + +Q + F E+ ++ Sbjct: 8 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVL 67 Query: 369 SQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAE 548 + H I+ G + ++ +V ++ +LY +H + ++IA QTA+ Sbjct: 68 RKTRHVNILLFMGYSTKPQL-AIVTQWCEGSSLYHHLHIIE--TKFEMIKLIDIARQTAQ 124 Query: 549 ALSYLHSWASPPIIHGDVKTSNILLDE 629 + YLH + IIH D+K++NI L E Sbjct: 125 GMDYLH---AKSIIHRDLKSNNIFLHE 148
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 53.9 bits (128), Expect = 4e-07 Identities = 45/152 (29%), Positives = 69/152 (45%), Gaps = 9/152 (5%) Frame = +3 Query: 195 EELEEATGRFDERNVIGKGANGTVYKG-TTKDNELVAIKKCRLASERQ---QKEFGKEML 362 EE GR++ V+G+G VY T+ VA+K R R Q F +E Sbjct: 2 EEPRRLGGRYELGPVLGRGGMAEVYHAHDTRLGRQVAVKTLRADLARDPSFQARFRREAQ 61 Query: 363 IVSQINHRYIVKLYGCCLE----VEVPMLVYKYIPNGTLYRLIH-GRRDGPRIPFTARLN 527 + +NH IV +Y + V +P +V +Y+ TL L+H GR+ P + Sbjct: 62 SAASLNHPAIVAVYDTGEDYIDNVSIPYIVMEYVDGSTLRELLHSGRKLLPERTLEMTIG 121 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILL 623 I +AL Y H I+H D+K +N++L Sbjct: 122 IL----QALEYSHRAG---IVHRDIKPANVML 146
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 53.5 bits (127), Expect = 5e-07 Identities = 43/148 (29%), Positives = 74/148 (50%), Gaps = 12/148 (8%) Frame = +3 Query: 219 RFDERNV-----IGKGANGTVYK---GTTKDN--ELVAIKKCRLASERQQKEFGKEMLIV 368 +F+ER++ +GKG G+V +DN E+VA+KK + ++E ++F +E+ I+ Sbjct: 843 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL 902 Query: 369 SQINHRYIVKLYGCCLEV--EVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQT 542 + H IVK G C L+ +Y+P G+L + ++ RI L Q Sbjct: 903 KSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKE--RIDHKKLLQYTSQI 960 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILLD 626 + + YL + IH D+ T NIL++ Sbjct: 961 CKGMEYL---GTKRYIHRDLATRNILVE 985 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 8/136 (5%) Frame = +3 Query: 240 IGKGANGTVYKGTTKD--------NELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIV 395 +G+G ++KG ++ V +K A + F + ++SQ++H+++V Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLV 610 Query: 396 KLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWA 575 YG C+ E +LV +++ G+L + ++ I + +L +A Q A A+ +L Sbjct: 611 LNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILW--KLGVAKQLAWAMHFLE--- 665 Query: 576 SPPIIHGDVKTSNILL 623 +IHG+V NILL Sbjct: 666 EKSLIHGNVCAKNILL 681
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 53.5 bits (127), Expect = 5e-07 Identities = 43/148 (29%), Positives = 74/148 (50%), Gaps = 12/148 (8%) Frame = +3 Query: 219 RFDERNV-----IGKGANGTVYK---GTTKDN--ELVAIKKCRLASERQQKEFGKEMLIV 368 +F+ER++ +GKG G+V +DN E+VA+KK + ++E ++F +E+ I+ Sbjct: 843 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL 902 Query: 369 SQINHRYIVKLYGCCLEV--EVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQT 542 + H IVK G C L+ +Y+P G+L + ++ RI L Q Sbjct: 903 KSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKE--RIDHIKLLQYTSQI 960 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILLD 626 + + YL + IH D+ T NIL++ Sbjct: 961 CKGMEYL---GTKRYIHRDLATRNILVE 985 Score = 43.9 bits (102), Expect = 4e-04 Identities = 33/136 (24%), Positives = 67/136 (49%), Gaps = 8/136 (5%) Frame = +3 Query: 240 IGKGANGTVYKGTTKD--------NELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIV 395 +G+G ++KG ++ V +K A + F + ++S+++H+++V Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLV 610 Query: 396 KLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWA 575 YG C+ + +LV +++ G+L + +++ I +L +A Q A A+ +L Sbjct: 611 LNYGVCVCGDENILVQEFVKFGSLDTYL--KKNKNCINILWKLEVAKQLAWAMHFLE--- 665 Query: 576 SPPIIHGDVKTSNILL 623 +IHG+V NILL Sbjct: 666 ENTLIHGNVCAKNILL 681
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 53.5 bits (127), Expect = 5e-07 Identities = 48/144 (33%), Positives = 69/144 (47%), Gaps = 5/144 (3%) Frame = +3 Query: 207 EATGRFD--ERNVIGKGANGTVYKGTTKD-NELVAIKKC--RLASERQQKEFGKEMLIVS 371 E G+F+ +++IG GA V+KG ++ ++L KC + + Q GKE+ I+ Sbjct: 9 ETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILK 68 Query: 372 QINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEA 551 ++ H IV LY LV +Y G L +H R T RL + Q A A Sbjct: 69 ELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSED--TVRLFL-QQIAGA 125 Query: 552 LSYLHSWASPPIIHGDVKTSNILL 623 + LHS IIH D+K NILL Sbjct: 126 MRLLHSKG---IIHRDLKPQNILL 146
>M3K5_HUMAN (Q99683) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1374 Score = 53.5 bits (127), Expect = 5e-07 Identities = 42/150 (28%), Positives = 69/150 (46%), Gaps = 5/150 (3%) Frame = +3 Query: 192 QEELEEATGRFDE---RNVIGKGANGTVYKGTTKDNEL-VAIKKCRLASERQQKEFGKEM 359 + +L E +DE R V+GKG G VY G N++ +AIK+ R + +E+ Sbjct: 667 ESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEI 726 Query: 360 LIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNI-AH 536 + + H+ IV+ G E + + +P G+L L+ + GP + Sbjct: 727 ALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKW-GPLKDNEQTIGFYTK 785 Query: 537 QTAEALSYLHSWASPPIIHGDVKTSNILLD 626 Q E L YLH I+H D+K N+L++ Sbjct: 786 QILEGLKYLH---DNQIVHRDIKGDNVLIN 812
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 53.5 bits (127), Expect = 5e-07 Identities = 37/130 (28%), Positives = 65/130 (50%), Gaps = 1/130 (0%) Frame = +3 Query: 237 VIGKGANGTVYKGTTK-DNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCC 413 V+GKG G K T K +++ +K+ E QK F E+ ++ ++H ++K G Sbjct: 336 VLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVL 395 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + L+ +YI GTL + R+ P+ +++ A A ++YLHS IIH Sbjct: 396 YKDKKLNLLTEYIEGGTLKDFL---RNADPFPWQQKVSFAKGIASGMAYLHSMC---IIH 449 Query: 594 GDVKTSNILL 623 D+ + N L+ Sbjct: 450 RDLNSHNCLI 459
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 53.5 bits (127), Expect = 5e-07 Identities = 43/148 (29%), Positives = 74/148 (50%), Gaps = 12/148 (8%) Frame = +3 Query: 219 RFDERNV-----IGKGANGTVYK---GTTKDN--ELVAIKKCRLASERQQKEFGKEMLIV 368 +F+ER++ +GKG G+V +DN E+VA+KK + ++E ++F +E+ I+ Sbjct: 843 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL 902 Query: 369 SQINHRYIVKLYGCCLEV--EVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQT 542 + H IVK G C L+ +Y+P G+L + ++ RI L Q Sbjct: 903 KSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKE--RIDHKKLLQYTSQI 960 Query: 543 AEALSYLHSWASPPIIHGDVKTSNILLD 626 + + YL + IH D+ T NIL++ Sbjct: 961 CKGMEYL---GTKRYIHRDLATRNILVE 985 Score = 48.1 bits (113), Expect = 2e-05 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 8/136 (5%) Frame = +3 Query: 240 IGKGANGTVYKGTTKD--------NELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIV 395 +G+G ++KG ++ V +K A + F + ++SQ++H+++V Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLV 610 Query: 396 KLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWA 575 YG C+ E +LV +++ G+L + ++ I + +L +A Q A A+ +L Sbjct: 611 LNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILW--KLGVAKQLAWAMHFLE--- 665 Query: 576 SPPIIHGDVKTSNILL 623 +IHG+V NILL Sbjct: 666 EKSLIHGNVCAKNILL 681
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 53.5 bits (127), Expect = 5e-07 Identities = 39/130 (30%), Positives = 64/130 (49%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 IG G+ GTVYKG + V I K + Q + F E+ ++ + H I+ G + Sbjct: 346 IGSGSFGTVYKGKWHGDVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTK 405 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 + +V ++ +LY +H + ++IA QTA+ + YLH + IIH D Sbjct: 406 DNL-AIVTQWCEGSSLYYHLHVL--DTKFQMFQLIDIARQTAQGMDYLH---AKNIIHRD 459 Query: 600 VKTSNILLDE 629 +K++NI L E Sbjct: 460 MKSNNIFLHE 469
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 53.1 bits (126), Expect = 7e-07 Identities = 36/130 (27%), Positives = 62/130 (47%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 IG G+ GTV++G + V + K + Q + F EM ++ + H I+ G Sbjct: 316 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 375 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 ++ ++ +LY +H R +++A QTA+ + YLH + IIH D Sbjct: 376 PGFAIIT-QWCEGSSLYHHLHVA--DTRFDMVQLIDVARQTAQGMDYLH---AKNIIHRD 429 Query: 600 VKTSNILLDE 629 +K++NI L E Sbjct: 430 LKSNNIFLHE 439
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 53.1 bits (126), Expect = 7e-07 Identities = 36/130 (27%), Positives = 62/130 (47%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 IG G+ GTV++G + V + K + Q + F EM ++ + H I+ G Sbjct: 316 IGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 375 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 ++ ++ +LY +H R +++A QTA+ + YLH + IIH D Sbjct: 376 PGFAIIT-QWCEGSSLYHHLHVA--DTRFDMVQLIDVARQTAQGMDYLH---AKNIIHRD 429 Query: 600 VKTSNILLDE 629 +K++NI L E Sbjct: 430 LKSNNIFLHE 439
>SEA_AVIET (P23049) Tyrosine-protein kinase transforming protein SEA (EC| 2.7.10.2) Length = 370 Score = 53.1 bits (126), Expect = 7e-07 Identities = 39/137 (28%), Positives = 65/137 (47%), Gaps = 6/137 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGTTKD----NELVAIKKC-RLASERQQKEFGKEMLIVSQINHRYIVKL 401 VIG+G G+VY GT D N A+K R+ + +EF +E +++ +H ++ L Sbjct: 65 VIGRGHFGSVYHGTYMDPLLGNLHCAVKSLHRITYLEEVEEFLREGILMKGFHHPQVLSL 124 Query: 402 YGCCLEVE-VPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 G CL +P++V Y+ +G L + + P + + Q A + YL A Sbjct: 125 LGVCLPRHGLPLVVLPYMRHGDLRHFVRAQERSPTV--KELIGFGLQVALGMEYL---AQ 179 Query: 579 PPIIHGDVKTSNILLDE 629 +H D+ N +LDE Sbjct: 180 KKFVHRDLAARNCMLDE 196
>IKKA_HUMAN (O15111) Inhibitor of nuclear factor kappa-B kinase alpha subunit| (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor N Length = 745 Score = 53.1 bits (126), Expect = 7e-07 Identities = 41/147 (27%), Positives = 73/147 (49%), Gaps = 7/147 (4%) Frame = +3 Query: 210 ATGRFDERNVIGKGANGTVYKGTTKDNEL-VAIKKCRLA-SERQQKEFGKEMLIVSQINH 383 A G ++ R +G G G V ++ +L +AIK CRL S + ++ + E+ I+ ++NH Sbjct: 11 AGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNH 70 Query: 384 RYIVKLYGCCLEV-----EVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAE 548 +VK E+ +VP+L +Y G L +L++ + + + L++ Sbjct: 71 ANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGS 130 Query: 549 ALSYLHSWASPPIIHGDVKTSNILLDE 629 + YLH IIH D+K NI+L + Sbjct: 131 GIRYLHE---NKIIHRDLKPENIVLQD 154
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 53.1 bits (126), Expect = 7e-07 Identities = 36/130 (27%), Positives = 62/130 (47%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 IG G+ GTV++G + V + K + Q + F EM ++ + H I+ G Sbjct: 314 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 373 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 ++ ++ +LY +H R +++A QTA+ + YLH + IIH D Sbjct: 374 PGFAIIT-QWCEGSSLYHHLHVA--DTRFDMVQLIDVARQTAQGMDYLH---AKNIIHRD 427 Query: 600 VKTSNILLDE 629 +K++NI L E Sbjct: 428 LKSNNIFLHE 437
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 53.1 bits (126), Expect = 7e-07 Identities = 36/130 (27%), Positives = 62/130 (47%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 IG G+ GTV++G + V + K + Q + F EM ++ + H I+ G Sbjct: 314 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 373 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 ++ ++ +LY +H R +++A QTA+ + YLH + IIH D Sbjct: 374 PGFAIIT-QWCEGSSLYHHLHVA--DTRFDMVQLIDVARQTAQGMDYLH---AKNIIHRD 427 Query: 600 VKTSNILLDE 629 +K++NI L E Sbjct: 428 LKSNNIFLHE 437
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 53.1 bits (126), Expect = 7e-07 Identities = 46/154 (29%), Positives = 77/154 (50%), Gaps = 13/154 (8%) Frame = +3 Query: 204 EEATG-RFDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKE--------FGK 353 EEA R+ + +IG GA G VY G D+ EL+AIK+ +A KE + Sbjct: 61 EEAPSIRWRKGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEE 120 Query: 354 EMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPR---IPFTARL 524 E+ ++ ++H IV+ G E + ++ +++P G++ L+ P I +T +L Sbjct: 121 EVQLLKNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQL 180 Query: 525 NIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 + L YLH+ I+H D+K +NIL+D Sbjct: 181 LLG------LEYLHNNG---IMHRDIKGANILVD 205
>ERBB_ALV (P00534) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 634 Score = 53.1 bits (126), Expect = 7e-07 Identities = 44/140 (31%), Positives = 69/140 (49%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGT-----TKDNELVAIKKCRLA-SERQQKEFGKEMLIVSQINH 383 F + V+G GA GTVYKG K VAIK+ R A S + KE E +++ +++ Sbjct: 132 FKKVKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 191 Query: 384 RYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYL 563 ++ +L G CL V L+ + +P G L I +D I LN Q A+ ++YL Sbjct: 192 PHVCRLLGICLTSTV-QLITQLMPYGCLLDYIREHKD--NIGSQYLLNWCVQIAKGMNYL 248 Query: 564 HSWASPPIIHGDVKTSNILL 623 ++H D+ N+L+ Sbjct: 249 E---ERRLVHRDLAARNVLV 265
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 53.1 bits (126), Expect = 7e-07 Identities = 41/138 (29%), Positives = 68/138 (49%), Gaps = 6/138 (4%) Frame = +3 Query: 231 RNVIGKGANGTVYKGTTKDNE-----LVAIKKCRLA-SERQQKEFGKEMLIVSQINHRYI 392 + VIG G G VYKGT K + VAIK + +E+Q+ +F E I+ Q +H I Sbjct: 617 QKVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNI 676 Query: 393 VKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSW 572 + L G + + M++ +Y+ NG L + + +DG + + A + YL Sbjct: 677 IPLEGVVSKYKPMMIITEYMENGALDKFLR-EKDG-EFSVLQLVGMLRGIASGMKYL--- 731 Query: 573 ASPPIIHGDVKTSNILLD 626 A+ +H D+ NIL++ Sbjct: 732 ANMNYVHRDLAARNILVN 749
>ERBB2_HUMAN (P04626) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19) Length = 1255 Score = 52.8 bits (125), Expect = 8e-07 Identities = 47/135 (34%), Positives = 66/135 (48%), Gaps = 6/135 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGT-TKDNE----LVAIKKCR-LASERQQKEFGKEMLIVSQINHRYIVK 398 V+G GA GTVYKG D E VAIK R S + KE E +++ + Y+ + Sbjct: 725 VLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSR 784 Query: 399 LYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 L G CL V LV + +P G L L H R + R+ LN Q A+ +SYL Sbjct: 785 LLGICLTSTV-QLVTQLMPYGCL--LDHVRENRGRLGSQDLLNWCMQIAKGMSYLE---D 838 Query: 579 PPIIHGDVKTSNILL 623 ++H D+ N+L+ Sbjct: 839 VRLVHRDLAARNVLV 853
>STK10_MOUSE (O55098) Serine/threonine-protein kinase 10 (EC 2.7.11.1)| (Lymphocyte-oriented kinase) Length = 966 Score = 52.8 bits (125), Expect = 8e-07 Identities = 41/132 (31%), Positives = 64/132 (48%), Gaps = 4/132 (3%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCL 416 +G GA G VYK K+ L A K SE + +++ E+ I++ +H YIVKL G Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYY 101 Query: 417 EVEVPMLVYKYIPNGTLYRLIHGRRDG---PRIPFTARLNIAHQTAEALSYLHSWASPPI 587 ++ ++ P G + ++ G P+I R Q EAL++LH I Sbjct: 102 YDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCR-----QMLEALNFLH---GKRI 153 Query: 588 IHGDVKTSNILL 623 IH D+K N+L+ Sbjct: 154 IHRDLKAGNVLM 165
>ERBB3_MOUSE (Q61526) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Glial growth factor receptor) Length = 1339 Score = 52.8 bits (125), Expect = 8e-07 Identities = 49/196 (25%), Positives = 88/196 (44%), Gaps = 10/196 (5%) Frame = +3 Query: 66 AYMIYAKRRLA--KIKREYFEQHGGLTLFDEMRSRQGLSFKLFTQEELEEATGRFDERNV 239 +++ + RR+ + R Y E+ + D + ++F + EL + V Sbjct: 660 SFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKL-------KV 712 Query: 240 IGKGANGTVYKGT-TKDNELVAIKKCRLASERQQ-----KEFGKEMLIVSQINHRYIVKL 401 +G G GTV+KG + E + I C E + + ML V ++H +IV+L Sbjct: 713 LGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRL 772 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLIHGRRD--GPRIPFTARLNIAHQTAEALSYLHSWA 575 G C + LV +Y+P G+L + R+ GP++ LN Q A+ + YL + Sbjct: 773 LGLCPGSSL-QLVTQYLPLGSLLDHVRQHRETLGPQL----LLNWGVQIAKGMYYLEEHS 827 Query: 576 SPPIIHGDVKTSNILL 623 ++H D+ N++L Sbjct: 828 ---MVHRDLALRNVML 840
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 52.8 bits (125), Expect = 8e-07 Identities = 46/161 (28%), Positives = 75/161 (46%), Gaps = 14/161 (8%) Frame = +3 Query: 186 FTQEELEEATGRFDER---------NVIGKGANGTVYKGTTK---DNEL-VAIKKCRLA- 323 FT E+ EA F + VIG G G VYKG K E+ VAIK + Sbjct: 598 FTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY 657 Query: 324 SERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPR 503 SE+Q+++F E I+ Q +H I++L G + M++ +++ NG L + R++ + Sbjct: 658 SEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFL--RQNDGQ 715 Query: 504 IPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 + + A + YL A +H D+ NIL++ Sbjct: 716 FTVIQLVGMLRGIAAGMKYL---AEMNYVHRDLAARNILVN 753
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 52.8 bits (125), Expect = 8e-07 Identities = 46/161 (28%), Positives = 75/161 (46%), Gaps = 14/161 (8%) Frame = +3 Query: 186 FTQEELEEATGRFDER---------NVIGKGANGTVYKGTTK---DNEL-VAIKKCRLA- 323 FT E+ EA F + VIG G G VYKG K E+ VAIK + Sbjct: 598 FTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY 657 Query: 324 SERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPR 503 SE+Q+++F E I+ Q +H I++L G + M++ +++ NG L + R++ + Sbjct: 658 SEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFL--RQNDGQ 715 Query: 504 IPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 + + A + YL A +H D+ NIL++ Sbjct: 716 FTVIQLVGMLRGIAAGMKYL---AEMNYVHRDLAARNILVN 753
>ERBB_AVIER (P00535) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 604 Score = 52.8 bits (125), Expect = 8e-07 Identities = 43/140 (30%), Positives = 69/140 (49%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGT-----TKDNELVAIKKCRLA-SERQQKEFGKEMLIVSQINH 383 F + V+G GA GT+YKG K VAIK+ R A S + KE E +++ +++ Sbjct: 132 FKKVKVLGSGAFGTIYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 191 Query: 384 RYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYL 563 ++ +L G CL V L+ + +P G L I +D I LN Q A+ ++YL Sbjct: 192 PHVCRLLGICLTSTV-QLITQLMPYGCLLDYIREHKD--NIGSQYLLNWCVQIAKGMNYL 248 Query: 564 HSWASPPIIHGDVKTSNILL 623 ++H D+ N+L+ Sbjct: 249 E---ERRLVHRDLAARNVLV 265
>TAOK2_XENLA (Q6GPK9) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1025 Score = 52.8 bits (125), Expect = 8e-07 Identities = 44/154 (28%), Positives = 74/154 (48%), Gaps = 4/154 (2%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKGTT-KDNELVAIKKCRLASERQQKEFG-- 350 +LF +++ E+ F + IG G+ G VY ++NE+VAIKK + ++ +++ Sbjct: 17 ELFFKDDPEKL---FADLREIGHGSFGAVYFARDIRNNEVVAIKKMSYSGKQSNEKWQDI 73 Query: 351 -KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLN 527 KE+ + ++ H ++ GC L LV +Y L ++ + A Sbjct: 74 IKEVKFLQKLRHPNTIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEMEIAA--- 130 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 I H + L+YLH+ +IH DVK NILL E Sbjct: 131 ITHGALQGLAYLHNHN---MIHRDVKAGNILLTE 161
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 52.8 bits (125), Expect = 8e-07 Identities = 36/130 (27%), Positives = 63/130 (48%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 +G G G V++G VA+K + + +EF +E I+ Q+ H +++LY C + Sbjct: 246 LGAGQFGEVWEGLWNGTTSVAVKTLKPGT-MSIEEFLEEASIMKQLRHPKLIQLYAVCTK 304 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 E +V + + +G+L + G DG + +++ Q A +SYL IH D Sbjct: 305 EEPIYIVTELMKHGSLLEYLRG--DGRSLKLPDLVDMCSQVASGMSYLE---QQNYIHRD 359 Query: 600 VKTSNILLDE 629 + NIL+ E Sbjct: 360 LAARNILVGE 369
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 52.8 bits (125), Expect = 8e-07 Identities = 39/130 (30%), Positives = 65/130 (50%), Gaps = 3/130 (2%) Frame = +3 Query: 240 IGKGANGTVYKG-TTKDNELVAIKKCRLAS--ERQQKEFGKEMLIVSQINHRYIVKLYGC 410 +GKGA G VY+G K+ E VA+KK +L+ + E+ ++ ++H IVK G Sbjct: 15 LGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVKYRGS 74 Query: 411 CLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPII 590 + ++ +Y NG+L + ++ +IP Q + L YLH+ +I Sbjct: 75 YQTNDSLCIILEYCENGSLRSIC---KNFGKIPENLVALYTFQVLQGLLYLHNQG---VI 128 Query: 591 HGDVKTSNIL 620 H D+K +NIL Sbjct: 129 HRDIKGANIL 138
>TAO1A_XENLA (Q6NU21) Serine/threonine-protein kinase TAO1-A (EC 2.7.11.1)| (Thousand and one amino acid protein 1-A) Length = 1001 Score = 52.8 bits (125), Expect = 8e-07 Identities = 45/154 (29%), Positives = 71/154 (46%), Gaps = 4/154 (2%) Frame = +3 Query: 180 KLFTQEELEEATGRFDERNVIGKGANGTVYKG-TTKDNELVAIKKCRLASERQQKEFG-- 350 +LF +++ E+ F + IG G+ G VY E+VAIKK + ++ +++ Sbjct: 17 ELFFRDDPEKL---FSDLREIGHGSFGAVYFAHDASTREVVAIKKMSYSGKQSNEKWQDI 73 Query: 351 -KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLN 527 KE+ + +I H ++ GC L LV +Y L ++ I A Sbjct: 74 VKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEIEIAA--- 130 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 I H + L+YLHS +IH D+K NILL E Sbjct: 131 ITHGALQGLAYLHSHN---LIHRDIKAGNILLTE 161
>ZAP70_HUMAN (P43403) Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa| zeta-associated protein) (Syk-related tyrosine kinase) Length = 619 Score = 52.8 bits (125), Expect = 8e-07 Identities = 39/132 (29%), Positives = 68/132 (51%), Gaps = 4/132 (3%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNEL---VAIKKCRLASERQQ-KEFGKEMLIVSQINHRYIVKLYG 407 +G G G+V +G + + VAIK + +E+ +E +E I+ Q+++ YIV+L G Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 Query: 408 CCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPI 587 C + E MLV + G L++ + G+R+ IP + + HQ + + YL Sbjct: 404 VC-QAEALMLVMEMAGGGPLHKFLVGKRE--EIPVSNVAELLHQVSMGMKYLE---EKNF 457 Query: 588 IHGDVKTSNILL 623 +H D+ N+LL Sbjct: 458 VHRDLAARNVLL 469
>EGFR_MOUSE (Q01279) Epidermal growth factor receptor precursor (EC 2.7.10.1)| Length = 1210 Score = 52.8 bits (125), Expect = 8e-07 Identities = 43/140 (30%), Positives = 69/140 (49%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGT-----TKDNELVAIKKCRLA-SERQQKEFGKEMLIVSQINH 383 F + V+G GA GTVYKG K VAIK+ R A S + KE E +++ +++ Sbjct: 714 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 773 Query: 384 RYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYL 563 ++ +L G CL V L+ + +P G L + +D I LN Q A+ ++YL Sbjct: 774 PHVCRLLGICLTSTV-QLITQLMPYGCLLDYVREHKD--NIGSQYLLNWCVQIAKGMNYL 830 Query: 564 HSWASPPIIHGDVKTSNILL 623 ++H D+ N+L+ Sbjct: 831 E---DRRLVHRDLAARNVLV 847
>M3K5_MOUSE (O35099) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1380 Score = 52.8 bits (125), Expect = 8e-07 Identities = 38/135 (28%), Positives = 63/135 (46%), Gaps = 2/135 (1%) Frame = +3 Query: 228 ERNVIGKGANGTVYKGTTKDNEL-VAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLY 404 +R V+GKG G VY G N++ +AIK+ R + +E+ + + H+ IV+ Sbjct: 689 DRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYL 748 Query: 405 GCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNI-AHQTAEALSYLHSWASP 581 G E + + +P G+L L+ + GP + Q E L YLH Sbjct: 749 GSFSENGFIKIFMEQVPGGSLSALLRSKW-GPLKDNEQTIGFYTKQILEGLKYLH---DN 804 Query: 582 PIIHGDVKTSNILLD 626 I+H D+K N+L++ Sbjct: 805 QIVHRDIKGDNVLIN 819
>GSK3B_RAT (P18266) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) (Factor A) (FA) Length = 420 Score = 52.4 bits (124), Expect = 1e-06 Identities = 48/144 (33%), Positives = 72/144 (50%), Gaps = 9/144 (6%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEF-GKEMLIVSQINHRYIV 395 + + VIG G+ G VY+ D+ ELVAIKK Q K F +E+ I+ +++H IV Sbjct: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL-----QDKRFKNRELQIMRKLDHCNIV 110 Query: 396 KLY------GCCLEVEVPMLVYKYIPNGTLYRLI-HGRRDGPRIPFTARLNIAHQTAEAL 554 +L G + LV Y+P T+YR+ H R +P +Q +L Sbjct: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 Query: 555 SYLHSWASPPIIHGDVKTSNILLD 626 +Y+HS+ I H D+K N+LLD Sbjct: 170 AYIHSFG---ICHRDIKPQNLLLD 190
>GSK3B_MOUSE (Q9WV60) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 52.4 bits (124), Expect = 1e-06 Identities = 48/144 (33%), Positives = 72/144 (50%), Gaps = 9/144 (6%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEF-GKEMLIVSQINHRYIV 395 + + VIG G+ G VY+ D+ ELVAIKK Q K F +E+ I+ +++H IV Sbjct: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL-----QDKRFKNRELQIMRKLDHCNIV 110 Query: 396 KLY------GCCLEVEVPMLVYKYIPNGTLYRLI-HGRRDGPRIPFTARLNIAHQTAEAL 554 +L G + LV Y+P T+YR+ H R +P +Q +L Sbjct: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 Query: 555 SYLHSWASPPIIHGDVKTSNILLD 626 +Y+HS+ I H D+K N+LLD Sbjct: 170 AYIHSFG---ICHRDIKPQNLLLD 190
>GSK3B_HUMAN (P49841) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 52.4 bits (124), Expect = 1e-06 Identities = 48/144 (33%), Positives = 72/144 (50%), Gaps = 9/144 (6%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDN-ELVAIKKCRLASERQQKEF-GKEMLIVSQINHRYIV 395 + + VIG G+ G VY+ D+ ELVAIKK Q K F +E+ I+ +++H IV Sbjct: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVL-----QDKRFKNRELQIMRKLDHCNIV 110 Query: 396 KLY------GCCLEVEVPMLVYKYIPNGTLYRLI-HGRRDGPRIPFTARLNIAHQTAEAL 554 +L G + LV Y+P T+YR+ H R +P +Q +L Sbjct: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169 Query: 555 SYLHSWASPPIIHGDVKTSNILLD 626 +Y+HS+ I H D+K N+LLD Sbjct: 170 AYIHSFG---ICHRDIKPQNLLLD 190
>ERBB3_RAT (Q62799) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) Length = 1339 Score = 52.4 bits (124), Expect = 1e-06 Identities = 49/196 (25%), Positives = 88/196 (44%), Gaps = 10/196 (5%) Frame = +3 Query: 66 AYMIYAKRRLA--KIKREYFEQHGGLTLFDEMRSRQGLSFKLFTQEELEEATGRFDERNV 239 +++ + RR+ + R Y E+ + D + ++F + EL + V Sbjct: 660 SFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKL-------KV 712 Query: 240 IGKGANGTVYKGT-TKDNELVAIKKCRLASERQQ-----KEFGKEMLIVSQINHRYIVKL 401 +G G GTV+KG + E + I C E + + ML V ++H +IV+L Sbjct: 713 LGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRL 772 Query: 402 YGCCLEVEVPMLVYKYIPNGTLYRLIHGRRD--GPRIPFTARLNIAHQTAEALSYLHSWA 575 G C + LV +Y+P G+L + R+ GP++ LN Q A+ + YL + Sbjct: 773 LGLCPGSSL-QLVTQYLPLGSLLDHVKQHRETLGPQL----LLNWGVQIAKGMYYLEEHS 827 Query: 576 SPPIIHGDVKTSNILL 623 ++H D+ N++L Sbjct: 828 ---MVHRDLALRNVML 840
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 52.4 bits (124), Expect = 1e-06 Identities = 50/194 (25%), Positives = 87/194 (44%), Gaps = 11/194 (5%) Frame = +3 Query: 81 AKRRLAKIKREYFEQHGGLTLFDEMRSRQGLSFKLFTQEELEEATGRFDERNVIGKGANG 260 A++ K+KR+ + G T E+ +S + E + + +IGKG+ G Sbjct: 1130 ARKNSVKLKRQNTKMWG--TRMVEVTENHMVSINKAKNSKGEYKEFAWMKGEMIGKGSFG 1187 Query: 261 TVYKG-TTKDNELVAIKKCRLASERQQKE--------FGKEMLIVSQINHRYIVKLYGCC 413 VY E++A+K+ + Q E E+ + ++H IV+ G Sbjct: 1188 AVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFE 1247 Query: 414 LEVEVPMLVYKYIPNGTLYRLI--HGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPI 587 + + L +Y+ G++ LI +GR D P I ++ Q + L+YLHS I Sbjct: 1248 NKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIK-----HLTTQVLKGLAYLHSKG---I 1299 Query: 588 IHGDVKTSNILLDE 629 +H D+K N+LLD+ Sbjct: 1300 LHRDMKADNLLLDQ 1313
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 52.4 bits (124), Expect = 1e-06 Identities = 36/132 (27%), Positives = 59/132 (44%) Frame = +3 Query: 234 NVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCC 413 N +G G G VY+G K ++ K EF E I+ ++H+ +V+L G C Sbjct: 315 NKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVC 374 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 ++ +++ NG L + R D +P + +A Q A +SYL + IH Sbjct: 375 THEAPFYIITEFMCNGNLLEYLR-RTDKSLLPPIILVQMASQIASGMSYLE---ARHFIH 430 Query: 594 GDVKTSNILLDE 629 D+ N L+ E Sbjct: 431 RDLAARNCLVSE 442
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 52.4 bits (124), Expect = 1e-06 Identities = 38/156 (24%), Positives = 75/156 (48%), Gaps = 1/156 (0%) Frame = +3 Query: 165 QGLSFKLFTQEELEEATGRFDERNVIGKGANGTVYKGTTKDNELVAIKKCRLASERQQKE 344 +GLS + Q E++ + +F + +G G G V++G + VAIK + + K+ Sbjct: 231 EGLSHRTRDQWEIDRTSLKFVRK--LGSGQFGDVWEGLWNNTTPVAIKTLK-SGTMDPKD 287 Query: 345 FGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHG-RRDGPRIPFTAR 521 F E I+ ++ H +++LY C E ++ + + +G+L + G + Sbjct: 288 FLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTL 347 Query: 522 LNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLDE 629 +++A Q A ++YL S IH D+ N+L+ + Sbjct: 348 IDMAAQIAAGMAYLE---SQNYIHRDLAARNVLVGD 380
>EGFR_HUMAN (P00533) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Receptor tyrosine-protein kinase ErbB-1) Length = 1210 Score = 52.4 bits (124), Expect = 1e-06 Identities = 43/140 (30%), Positives = 69/140 (49%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGT-----TKDNELVAIKKCRLA-SERQQKEFGKEMLIVSQINH 383 F + V+G GA GTVYKG K VAIK+ R A S + KE E +++ +++ Sbjct: 712 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 771 Query: 384 RYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYL 563 ++ +L G CL V L+ + +P G L + +D I LN Q A+ ++YL Sbjct: 772 PHVCRLLGICLTSTV-QLITQLMPFGCLLDYVREHKD--NIGSQYLLNWCVQIAKGMNYL 828 Query: 564 HSWASPPIIHGDVKTSNILL 623 ++H D+ N+L+ Sbjct: 829 E---DRRLVHRDLAARNVLV 845
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 52.4 bits (124), Expect = 1e-06 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGTTKDNE-LVAIK---KCRLASERQQKEFGKEMLIVSQINHRY 389 F+ +GKG G VY K + +VA+K K ++ E + + +E+ I + + H Sbjct: 80 FEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPN 139 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIH--GRRDGPRIPFTARLNIAHQTAEALSYL 563 I++LY + + L+ +Y P G LY+ + G D R I + ++AL Y Sbjct: 140 ILQLYNYFYDQQRIYLILEYAPRGELYKELQKSGTFDEQR-----TATIMEELSDALMYC 194 Query: 564 HSWASPPIIHGDVKTSNILL 623 H +IH D+K N+LL Sbjct: 195 H---KKKVIHRDIKPENLLL 211
>EGFR_DROME (P04412) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Egfr) (Gurken receptor) (Protein torpedo) (Drosophila relative of ERBB) Length = 1426 Score = 52.0 bits (123), Expect = 1e-06 Identities = 42/135 (31%), Positives = 68/135 (50%), Gaps = 6/135 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGT-TKDNE----LVAIKK-CRLASERQQKEFGKEMLIVSQINHRYIVK 398 V+G GA G VYKG + E VAIK+ + +EF +E I++ H ++K Sbjct: 943 VLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLK 1002 Query: 399 LYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 L C+ ++ ML+ + +P G L + RD +I A LN + Q A+ +SYL Sbjct: 1003 LLAVCMSSQM-MLITQLMPLGCLLDYVRNNRD--KIGSKALLNWSTQIAKGMSYLE---E 1056 Query: 579 PPIIHGDVKTSNILL 623 ++H D+ N+L+ Sbjct: 1057 KRLVHRDLAARNVLV 1071
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 52.0 bits (123), Expect = 1e-06 Identities = 46/143 (32%), Positives = 66/143 (46%), Gaps = 5/143 (3%) Frame = +3 Query: 213 TGRFDERNVIGKGANGTVY--KGTTKDNELVAIKKCRLASERQQ---KEFGKEMLIVSQI 377 +GR+ VIG G VY + D E VAIK R + F +E S + Sbjct: 8 SGRYQILRVIGGGGMANVYLAEDIILDRE-VAIKILRFDYANDNEFIRRFRREAQSASSL 66 Query: 378 NHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALS 557 +H IV +Y E ++ +V +Y+ TL I +GP P A LNI Q A++ Sbjct: 67 DHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA--NGPLHPKEA-LNIMEQIVSAIA 123 Query: 558 YLHSWASPPIIHGDVKTSNILLD 626 + H I+H D+K NIL+D Sbjct: 124 HAHQ---NQIVHRDIKPHNILID 143
>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)| (NimA-related protein kinase 8) Length = 697 Score = 52.0 bits (123), Expect = 1e-06 Identities = 39/140 (27%), Positives = 69/140 (49%), Gaps = 3/140 (2%) Frame = +3 Query: 219 RFDERNVIGKGANGTVYKGTTK-DNELVAIKKCRLASERQQKEFG--KEMLIVSQINHRY 389 ++++ V+G+GA G V+ + D+ LV +K+ + + + E ++ ++H Sbjct: 3 KYEKTKVVGRGAFGIVHLCRRRTDSALVILKEIPVEQMTRDERLAAQNECQVLKLLSHPN 62 Query: 390 IVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHS 569 I++ Y LE + M+ +Y P GTL I R + T I H + L L+ Sbjct: 63 IIEYYENFLEDKALMIAMEYAPGGTLADYIQKRCNSLLDEDT----ILHSFVQILLALYH 118 Query: 570 WASPPIIHGDVKTSNILLDE 629 + I+H D+KT NILLD+ Sbjct: 119 VHNKLILHRDLKTQNILLDK 138
>M4K2_MOUSE (Q61161) Mitogen-activated protein kinase kinase kinase kinase 2| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein) Length = 821 Score = 52.0 bits (123), Expect = 1e-06 Identities = 42/148 (28%), Positives = 64/148 (43%), Gaps = 1/148 (0%) Frame = +3 Query: 183 LFTQEELEEATGRFDERNVIGKGANGTVYKGT-TKDNELVAIKKCRLASERQQKEFGKEM 359 L L++ RF+ +G G G VYK T +EL A+K +L +E+ Sbjct: 3 LLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEI 62 Query: 360 LIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQ 539 I+ + H +V G L + + ++ G+L + H GP IA+ Sbjct: 63 TILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHAT--GP----LEERQIAYV 116 Query: 540 TAEALSYLHSWASPPIIHGDVKTSNILL 623 EAL LH S IH D+K +N+LL Sbjct: 117 CREALKGLHHLHSQGKIHRDIKGANLLL 144
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 52.0 bits (123), Expect = 1e-06 Identities = 34/130 (26%), Positives = 60/130 (46%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 +G G G V++ K VA+K + Q F E+ + ++ H++I+ LY Sbjct: 197 LGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATA 256 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 + ++ + +P G L +L+ D +P ++ A Q AE + YL S IH D Sbjct: 257 GDPVYIITELMPKGNLLQLLRD-SDEKALPILELVDFASQVAEGMCYLE---SQNYIHRD 312 Query: 600 VKTSNILLDE 629 + N+L+ E Sbjct: 313 LAARNVLVTE 322
>ROS_HUMAN (P08922) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2347 Score = 52.0 bits (123), Expect = 1e-06 Identities = 47/161 (29%), Positives = 73/161 (45%), Gaps = 16/161 (9%) Frame = +3 Query: 189 TQEELEEATG----RFDERNVIGKGANGTVYKGTTKD------NEL-VAIKKCRLASERQ 335 TQEE+E + R ++G GA G VY+GT D E+ VA+K + S Q Sbjct: 1930 TQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQ 1989 Query: 336 QK-EFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRR----DGP 500 +K EF KE ++S+ NH I+K G CL E ++ + + G L + R GP Sbjct: 1990 EKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP 2049 Query: 501 RIPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILL 623 + +++ ++ YL IH D+ N L+ Sbjct: 2050 LLTLVDLVDLCVDISKGCVYLERM---HFIHRDLAARNCLV 2087
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 52.0 bits (123), Expect = 1e-06 Identities = 37/130 (28%), Positives = 64/130 (49%), Gaps = 1/130 (0%) Frame = +3 Query: 237 VIGKGANGTVYKGTTK-DNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCC 413 V+GKG G K T K +++ +K+ E QK F E+ ++ ++H ++K G Sbjct: 336 VLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVL 395 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + L+ +YI GTL + R+ P+ ++ A A ++YLHS IIH Sbjct: 396 YKDKKLNLLTEYIEGGTLKDFL---RNVDPFPWQQKVRFAKGIASGMAYLHSMC---IIH 449 Query: 594 GDVKTSNILL 623 D+ + N L+ Sbjct: 450 RDLNSHNCLI 459
>CD2L7_HUMAN (Q9NYV4) Cell division cycle 2-related protein kinase 7 (EC| 2.7.11.22) (CDC2-related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) Length = 1490 Score = 52.0 bits (123), Expect = 1e-06 Identities = 45/153 (29%), Positives = 72/153 (47%), Gaps = 17/153 (11%) Frame = +3 Query: 219 RFDERNVIGKGANGTVYKGTTKD-NELVAIKKCRLASERQQKEFG--KEMLIVSQINHRY 389 +FD +IG+G G VYK KD ELVA+KK RL +E++ +E+ I+ Q+ HR Sbjct: 726 KFDIIGIIGEGTYGQVYKARDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRS 785 Query: 390 IVKLYGCCLEVEVPM----------LVYKYIPNGTL----YRLIHGRRDGPRIPFTARLN 527 +V + + + + LV++Y+ + + L+H D + + Sbjct: 786 VVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIK-------S 838 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 Q E L Y H +H D+K SNILL+ Sbjct: 839 FMKQLMEGLEYCH---KKNFLHRDIKCSNILLN 868
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 52.0 bits (123), Expect = 1e-06 Identities = 35/130 (26%), Positives = 61/130 (46%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 IG G+ GTVY+ V + S Q + F E+ ++ + H I+ GC + Sbjct: 435 IGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSK 494 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIHGD 599 + +V ++ +LY+ +H + ++I Q A+ + YLH + IIH D Sbjct: 495 PSL-AIVTQWCEGSSLYKHVHVSE--TKFKLNTLIDIGRQVAQGMDYLH---AKNIIHRD 548 Query: 600 VKTSNILLDE 629 +K++NI L E Sbjct: 549 LKSNNIFLHE 558
>ERBB2_MOUSE (P70424) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) Length = 1256 Score = 51.6 bits (122), Expect = 2e-06 Identities = 47/135 (34%), Positives = 65/135 (48%), Gaps = 6/135 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGT-TKDNE----LVAIKKCR-LASERQQKEFGKEMLIVSQINHRYIVK 398 V+G GA GTVYKG D E VAIK R S + KE E +++ + Y+ + Sbjct: 726 VLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSR 785 Query: 399 LYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 L G CL V LV + +P G L L H R R+ LN Q A+ +SYL Sbjct: 786 LLGICLTSTV-QLVTQLMPYGCL--LDHVREHRGRLGSQDLLNWCVQIAKGMSYLE---E 839 Query: 579 PPIIHGDVKTSNILL 623 ++H D+ N+L+ Sbjct: 840 VRLVHRDLAARNVLV 854
>ERBB2_RAT (P06494) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Epidermal growth factor receptor-related protein) Length = 1257 Score = 51.6 bits (122), Expect = 2e-06 Identities = 47/135 (34%), Positives = 65/135 (48%), Gaps = 6/135 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGT-TKDNE----LVAIKKCR-LASERQQKEFGKEMLIVSQINHRYIVK 398 V+G GA GTVYKG D E VAIK R S + KE E +++ + Y+ + Sbjct: 727 VLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSR 786 Query: 399 LYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 L G CL V LV + +P G L L H R R+ LN Q A+ +SYL Sbjct: 787 LLGICLTSTV-QLVTQLMPYGCL--LDHVREHRGRLGSQDLLNWCVQIAKGMSYLE---D 840 Query: 579 PPIIHGDVKTSNILL 623 ++H D+ N+L+ Sbjct: 841 VRLVHRDLAARNVLV 855
>ULK2_HUMAN (Q8IYT8) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) Length = 1036 Score = 51.6 bits (122), Expect = 2e-06 Identities = 48/144 (33%), Positives = 69/144 (47%), Gaps = 5/144 (3%) Frame = +3 Query: 207 EATGRFD--ERNVIGKGANGTVYKGT--TKDNELVAIKKCRLAS-ERQQKEFGKEMLIVS 371 E G F+ +R+++G GA V++G K + VAIK + + Q GKE+ I+ Sbjct: 2 EVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILK 61 Query: 372 QINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEA 551 ++ H IV LY LV +Y G L + + G T R+ + HQ A A Sbjct: 62 ELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAK--GTLSEDTIRVFL-HQIAAA 118 Query: 552 LSYLHSWASPPIIHGDVKTSNILL 623 + LHS IIH D+K NILL Sbjct: 119 MRILHSKG---IIHRDLKPQNILL 139
>PK2_DICDI (P28178) Protein kinase 2 (EC 2.7.11.1)| Length = 479 Score = 51.6 bits (122), Expect = 2e-06 Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 8/156 (5%) Frame = +3 Query: 183 LFTQEELEEATGRFDERNVIGKGANGTVY----KGTTKDNELVAIKKCRLASERQQKEFG 350 +F++ + F+ NVIGKG+ G V KG K + ++K + + +Q Sbjct: 140 IFSKNKQSATKDDFELLNVIGKGSFGKVMQVKKKGEDKIFAMKVLRKDAIIARKQVNHTK 199 Query: 351 KEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDG----PRIPFTA 518 E I+ I+H +IV L+ + +V ++ G L+ H +R+G PR+ A Sbjct: 200 SEKTILQCISHPFIVNLHYAFQTKDKLYMVLDFVNGGELF--FHLKREGRFSEPRVKIYA 257 Query: 519 RLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 + AL +LH I++ D+K NILLD Sbjct: 258 A-----EIVSALDHLHK---QDIVYRDLKPENILLD 285
>CD2L5_HUMAN (Q14004) Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22)| (CDC2-related protein kinase 5) (Cholinesterase-related cell division controller) Length = 1512 Score = 51.6 bits (122), Expect = 2e-06 Identities = 43/151 (28%), Positives = 71/151 (47%), Gaps = 15/151 (9%) Frame = +3 Query: 219 RFDERNVIGKGANGTVYKGTTKD-NELVAIKKCRLASERQQKEFG--KEMLIVSQINHRY 389 +FD +IG+G G VYK KD E+VA+KK RL +E++ +E+ I+ Q+ H+ Sbjct: 704 KFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQS 763 Query: 390 IVKLYGCCLEVEVPM----------LVYKYIPNGTLYRLIHGRRDGPRIPFTAR--LNIA 533 I+ + + E + LV++Y+ + + G + + F + Sbjct: 764 IINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLM-----GLLESGLVHFNENHIKSFM 818 Query: 534 HQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 Q E L Y H +H D+K SNILL+ Sbjct: 819 RQLMEGLDYCH---KKNFLHRDIKCSNILLN 846
>IKKA_MOUSE (Q60680) Inhibitor of nuclear factor kappa-B kinase alpha subunit| (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor N Length = 745 Score = 51.6 bits (122), Expect = 2e-06 Identities = 40/147 (27%), Positives = 73/147 (49%), Gaps = 7/147 (4%) Frame = +3 Query: 210 ATGRFDERNVIGKGANGTVYKGTTKDNEL-VAIKKCRLA-SERQQKEFGKEMLIVSQINH 383 A G ++ R +G G G V ++ +L +AIK CRL S + ++ + E+ I+ +++H Sbjct: 11 AGGPWEMRERLGTGGFGNVSLYQHRELDLKIAIKSCRLELSSKNRERWCHEIQIMKKLDH 70 Query: 384 RYIVKLYGCCLEV-----EVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAE 548 +VK E+ +VP+L +Y G L +L++ + + + L++ Sbjct: 71 ANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGS 130 Query: 549 ALSYLHSWASPPIIHGDVKTSNILLDE 629 + YLH IIH D+K NI+L + Sbjct: 131 GIRYLHE---NKIIHRDLKPENIVLQD 154
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 51.6 bits (122), Expect = 2e-06 Identities = 45/161 (27%), Positives = 75/161 (46%), Gaps = 14/161 (8%) Frame = +3 Query: 186 FTQEELEEATGRFDER---------NVIGKGANGTVYKGTTK---DNEL-VAIKKCRLA- 323 FT E+ EA F + VIG G G VYKG K E+ VAIK + Sbjct: 598 FTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY 657 Query: 324 SERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPR 503 SE+Q+++F E I+ Q +H I++L G + M++ +++ NG L + R++ + Sbjct: 658 SEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFL--RQNDGQ 715 Query: 504 IPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 + + A + YL + +H D+ NIL++ Sbjct: 716 FTVIQLVGMLRGIAAGMKYL---SEMNYVHRDLAARNILVN 753
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 51.6 bits (122), Expect = 2e-06 Identities = 30/93 (32%), Positives = 56/93 (60%), Gaps = 1/93 (1%) Frame = +3 Query: 351 KEMLIVSQINHRYIVKLYGCCLEVEVPM-LVYKYIPNGTLYRLIHGRRDGPRIPFTARLN 527 +E + +I ++IV +YG C + P+ +V +++ NG+L +++ + + R Sbjct: 70 EEAAKMKKIKFQHIVSIYGVCKQ---PLGIVMEFMANGSLEKVLSTHS----LCWKLRFR 122 Query: 528 IAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 I H+T+ A+++LHS PP++H D+K NILLD Sbjct: 123 IIHETSLAMNFLHS-IKPPLLHLDLKPGNILLD 154
>ERBB2_CANFA (O18735) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) Length = 1259 Score = 51.6 bits (122), Expect = 2e-06 Identities = 47/135 (34%), Positives = 65/135 (48%), Gaps = 6/135 (4%) Frame = +3 Query: 237 VIGKGANGTVYKGT-TKDNE----LVAIKKCR-LASERQQKEFGKEMLIVSQINHRYIVK 398 V+G GA GTVYKG D E VAIK R S + KE E +++ + Y+ + Sbjct: 724 VLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSR 783 Query: 399 LYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWAS 578 L G CL V LV + +P G L L H R R+ LN Q A+ +SYL Sbjct: 784 LLGICLTSTV-QLVTQLMPYGCL--LDHVREHRGRLGSQDLLNWCVQIAKGMSYLE---D 837 Query: 579 PPIIHGDVKTSNILL 623 ++H D+ N+L+ Sbjct: 838 VRLVHRDLAARNVLV 852
>WIN1_SCHPO (O74304) MAP kinase kinase kinase win1 (EC 2.7.11.25)| Length = 1436 Score = 51.6 bits (122), Expect = 2e-06 Identities = 42/144 (29%), Positives = 68/144 (47%), Gaps = 6/144 (4%) Frame = +3 Query: 213 TGRFDERNVIGKGANGTVYKGTTKD-NELVAIKKCRLASERQQKEFGK----EMLIVSQI 377 T R+ + +IG G+ GTVY+ D +L+A+K+ L R + K EML++ Sbjct: 1117 TIRWQQGGLIGSGSFGTVYRAVNLDTGDLMAVKEVALHKPRISRPMIKRIKGEMLVLELF 1176 Query: 378 NHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLI-HGRRDGPRIPFTARLNIAHQTAEAL 554 +H +V YG + E + + +L+ + +GR + + L Q E L Sbjct: 1177 DHPNVVSYYGIEVHREKVNIFMELCQGSSLFEFLRYGRIEDELVIQVYVL----QLLEGL 1232 Query: 555 SYLHSWASPPIIHGDVKTSNILLD 626 +Y+HS + H DVK NIL D Sbjct: 1233 AYIHSCG---VSHQDVKPENILFD 1253
>ULK2_MOUSE (Q9QY01) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2) Length = 1037 Score = 51.6 bits (122), Expect = 2e-06 Identities = 48/144 (33%), Positives = 69/144 (47%), Gaps = 5/144 (3%) Frame = +3 Query: 207 EATGRFD--ERNVIGKGANGTVYKGT--TKDNELVAIKKCRLAS-ERQQKEFGKEMLIVS 371 E G F+ +R+++G GA V++G K + VAIK + + Q GKE+ I+ Sbjct: 2 EVVGDFEYCKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILK 61 Query: 372 QINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEA 551 ++ H IV LY LV +Y G L + + G T R+ + HQ A A Sbjct: 62 ELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAK--GTLSEDTIRVFL-HQIAAA 118 Query: 552 LSYLHSWASPPIIHGDVKTSNILL 623 + LHS IIH D+K NILL Sbjct: 119 MRILHSKG---IIHRDLKPQNILL 139
>ERBB_AVIEU (P11273) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 540 Score = 51.6 bits (122), Expect = 2e-06 Identities = 44/140 (31%), Positives = 69/140 (49%), Gaps = 6/140 (4%) Frame = +3 Query: 222 FDERNVIGKGANGTVYKGT-----TKDNELVAIKKCRLA-SERQQKEFGKEMLIVSQINH 383 F + V+G GA GTVYKG K VAIK+ R A S + KE E +++ +++ Sbjct: 132 FKKVKVLGFGAFGTVYKGLWIPEGEKVTIPVAIKELREATSPKANKEILDEAYVMASVDN 191 Query: 384 RYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYL 563 ++ +L G CL V L+ + +P G L I +D I LN Q A+ ++YL Sbjct: 192 PHVCRLLGICLTSTV-QLITQLMPYGCLLDYIREHKD--NIGSQYLLNWCVQIAKGMNYL 248 Query: 564 HSWASPPIIHGDVKTSNILL 623 ++H D+ N+L+ Sbjct: 249 E---ERHMVHRDLAARNVLV 265
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 51.6 bits (122), Expect = 2e-06 Identities = 37/130 (28%), Positives = 63/130 (48%), Gaps = 1/130 (0%) Frame = +3 Query: 237 VIGKGANGTVYKGTTK-DNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCC 413 V+GKG G K T K +++ +K+ E QK F E+ ++ ++H ++K G Sbjct: 336 VLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVL 395 Query: 414 LEVEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSYLHSWASPPIIH 593 + + L+ +YI GTL + R P+ ++ A A ++YLHS IIH Sbjct: 396 YKDKKLNLLTEYIEGGTLKDFL---RSMDPFPWQQKVRFAKGIASGMAYLHSMC---IIH 449 Query: 594 GDVKTSNILL 623 D+ + N L+ Sbjct: 450 RDLNSHNCLI 459
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 51.6 bits (122), Expect = 2e-06 Identities = 44/161 (27%), Positives = 74/161 (45%), Gaps = 14/161 (8%) Frame = +3 Query: 186 FTQEELEEATGRFDER---------NVIGKGANGTVYKG----TTKDNELVAIKKCRLA- 323 FT E+ EA F + VIG G G VYKG +K VAIK + Sbjct: 599 FTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPSKREISVAIKTLKAGY 658 Query: 324 SERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPR 503 SE+Q+++F E I+ Q +H I++L G + M++ +++ NG L + R++ + Sbjct: 659 SEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFL--RQNDGQ 716 Query: 504 IPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 + + A + YL + +H D+ NIL++ Sbjct: 717 FTVIQLVGMLRGIAAGMKYL---SEMNYVHRDLAARNILVN 754
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 51.6 bits (122), Expect = 2e-06 Identities = 44/161 (27%), Positives = 74/161 (45%), Gaps = 14/161 (8%) Frame = +3 Query: 186 FTQEELEEATGRFDER---------NVIGKGANGTVYKG----TTKDNELVAIKKCRLA- 323 FT E+ EA F + VIG G G VYKG +K VAIK + Sbjct: 516 FTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPSKREISVAIKTLKAGY 575 Query: 324 SERQQKEFGKEMLIVSQINHRYIVKLYGCCLEVEVPMLVYKYIPNGTLYRLIHGRRDGPR 503 SE+Q+++F E I+ Q +H I++L G + M++ +++ NG L + R++ + Sbjct: 576 SEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFL--RQNDGQ 633 Query: 504 IPFTARLNIAHQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 + + A + YL + +H D+ NIL++ Sbjct: 634 FTVIQLVGMLRGIAAGMKYL---SEMNYVHRDLAARNILVN 671
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 51.6 bits (122), Expect = 2e-06 Identities = 35/132 (26%), Positives = 66/132 (50%), Gaps = 2/132 (1%) Frame = +3 Query: 240 IGKGANGTVYKGTTKDNELVAIKKCRLASERQQKEFGKEMLIVSQINHRYIVKLYGCCLE 419 +G G G VY+G ++ VA+K + A Q F E I+ ++ H +++LY C + Sbjct: 101 LGAGQFGEVYQGLWNNSTPVAVKTLK-AGTMQPAAFLAEAQIMKKLRHPKLIQLYAVCTQ 159 Query: 420 VEVPMLVYKYIPNGTLYRLIHGRRDGPRIPFTARLNIAHQTAEALSY--LHSWASPPIIH 593 E ++ + + G+L + G ++P +++A Q A ++Y LH++ IH Sbjct: 160 GEPVYIITELMSKGSLLDYLQGEAGALKLP--QLIDMAAQVAAGMAYLELHNY-----IH 212 Query: 594 GDVKTSNILLDE 629 D+ NIL+ + Sbjct: 213 RDLAARNILVGD 224
>CD2L5_MOUSE (Q69ZA1) Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22)| (CDC2-related protein kinase 5) Length = 1511 Score = 51.6 bits (122), Expect = 2e-06 Identities = 43/151 (28%), Positives = 71/151 (47%), Gaps = 15/151 (9%) Frame = +3 Query: 219 RFDERNVIGKGANGTVYKGTTKD-NELVAIKKCRLASERQQKEFG--KEMLIVSQINHRY 389 +FD +IG+G G VYK KD E+VA+KK RL +E++ +E+ I+ Q+ H+ Sbjct: 704 KFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQS 763 Query: 390 IVKLYGCCLEVEVPM----------LVYKYIPNGTLYRLIHGRRDGPRIPFTAR--LNIA 533 I+ + + E + LV++Y+ + + G + + F + Sbjct: 764 IINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLM-----GLLESGLVHFNENHIKSFM 818 Query: 534 HQTAEALSYLHSWASPPIIHGDVKTSNILLD 626 Q E L Y H +H D+K SNILL+ Sbjct: 819 RQLMEGLDYCH---KKNFLHRDIKCSNILLN 846 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 66,807,666 Number of Sequences: 219361 Number of extensions: 1209089 Number of successful extensions: 6975 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6238 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6491 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5824436538 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
