ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | basd22d20 |
|---|---|
| Clone Library Name | barley_pub |
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 147 bits (371), Expect = 1e-35 Identities = 72/145 (49%), Positives = 103/145 (71%), Gaps = 3/145 (2%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGS-LEFRTEIELLSRVHHKN 184 ++NFS N +G GGFGKVY+G LA G LVAVKR +E QG L+F+TE+E++S H+N Sbjct: 286 SDNFSNKNILGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRN 345 Query: 185 VVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGK--SGVRLDWKRRLRVILGTAKGIAYLH 358 ++ L GFC+ E++LVY Y+ NG++ L + S LDW +R R+ LG+A+G+AYLH Sbjct: 346 LLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLH 405 Query: 359 ELADPPIVHRDIKSSNVLLDERLNA 433 + DP I+HRD+K++N+LLDE A Sbjct: 406 DHCDPKIIHRDVKAANILLDEEFEA 430
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 145 bits (365), Expect = 6e-35 Identities = 74/144 (51%), Positives = 95/144 (65%) Frame = +2 Query: 5 ITNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKN 184 ITNNF IG GGFGKVY G + G+ VAVK E S QG EFR E++LL RVHH N Sbjct: 572 ITNNFERV--IGKGGFGKVYHGVI-NGEQVAVKVLSEESAQGYKEFRAEVDLLMRVHHTN 628 Query: 185 VVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHEL 364 + SLVG+C + +L+YEY+ N L + L GK L W+ RL++ L A+G+ YLH Sbjct: 629 LTSLVGYCNEINHMVLIYEYMANENLGDYLAGKRSFILSWEERLKISLDAAQGLEYLHNG 688 Query: 365 ADPPIVHRDIKSSNVLLDERLNAK 436 PPIVHRD+K +N+LL+E+L AK Sbjct: 689 CKPPIVHRDVKPTNILLNEKLQAK 712
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 141 bits (355), Expect = 8e-34 Identities = 67/146 (45%), Positives = 101/146 (69%), Gaps = 3/146 (2%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTL-ATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKN 184 T NF +G GGFG+VY+G L +TGQ+VAVK+ LQG+ EF E+ +LS +HH N Sbjct: 83 TMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGNREFLVEVLMLSLLHHPN 142 Query: 185 VVSLVGFCLDQGEQMLVYEYIPNGTLKESL--TGKSGVRLDWKRRLRVILGTAKGIAYLH 358 +V+L+G+C D +++LVYE++P G+L++ L LDW R+++ G AKG+ +LH Sbjct: 143 LVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIAAGAAKGLEFLH 202 Query: 359 ELADPPIVHRDIKSSNVLLDERLNAK 436 + A+PP+++RD KSSN+LLDE + K Sbjct: 203 DKANPPVIYRDFKSSNILLDEGFHPK 228
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 140 bits (353), Expect = 1e-33 Identities = 70/149 (46%), Positives = 103/149 (69%), Gaps = 5/149 (3%) Frame = +2 Query: 5 ITNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGS--LEFRTEIELLSRVHH 178 +TNNFS N +G+GGFG VY+G L G +AVKR + G + G EF++EI +L++V H Sbjct: 584 VTNNFSSDNILGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKGFAEFKSEIAVLTKVRH 643 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKESL--TGKSGVR-LDWKRRLRVILGTAKGIA 349 +++V+L+G+CLD E++LVYEY+P GTL L + G++ L WK+RL + L A+G+ Sbjct: 644 RHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLLWKQRLTLALDVARGVE 703 Query: 350 YLHELADPPIVHRDIKSSNVLLDERLNAK 436 YLH LA +HRD+K SN+LL + + AK Sbjct: 704 YLHGLAHQSFIHRDLKPSNILLGDDMRAK 732
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 138 bits (347), Expect = 7e-33 Identities = 68/136 (50%), Positives = 93/136 (68%), Gaps = 2/136 (1%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 IG GGFG VYRGTL GQ VAVK S QG+ EF E+ LLS + H+N+V L+G+C + Sbjct: 602 IGEGGFGSVYRGTLDDGQEVAVKVRSSTSTQGTREFDNELNLLSAIQHENLVPLLGYCNE 661 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVR--LDWKRRLRVILGTAKGIAYLHELADPPIVHR 388 +Q+LVY ++ NG+L + L G++ R LDW RL + LG A+G+AYLH ++HR Sbjct: 662 YDQQILVYPFMSNGSLLDRLYGEASKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHR 721 Query: 389 DIKSSNVLLDERLNAK 436 D+KSSN+LLD+ + AK Sbjct: 722 DVKSSNILLDQSMCAK 737
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 136 bits (342), Expect = 3e-32 Identities = 68/136 (50%), Positives = 91/136 (66%), Gaps = 2/136 (1%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 IG GGFG VYRGTL GQ VAVK S QG+ EF E+ LLS + H+N+V L+G+C + Sbjct: 601 IGEGGFGSVYRGTLDDGQEVAVKVRSATSTQGTREFDNELNLLSAIQHENLVPLLGYCNE 660 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVR--LDWKRRLRVILGTAKGIAYLHELADPPIVHR 388 +Q+LVY ++ NG+L + L G+ R LDW RL + LG A+G+AYLH ++HR Sbjct: 661 YDQQILVYPFMSNGSLLDRLYGEPAKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHR 720 Query: 389 DIKSSNVLLDERLNAK 436 D+KSSN+LLD + AK Sbjct: 721 DVKSSNILLDHSMCAK 736
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 136 bits (342), Expect = 3e-32 Identities = 70/144 (48%), Positives = 92/144 (63%), Gaps = 2/144 (1%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNV 187 TN+F + N IG GGFG VY+ TL G+ VA+K+ Q EF E+E LSR H N+ Sbjct: 731 TNSFDQANIIGCGGFGMVYKATLPDGKKVAIKKLSGDCGQIEREFEAEVETLSRAQHPNL 790 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSG--VRLDWKRRLRVILGTAKGIAYLHE 361 V L GFC + +++L+Y Y+ NG+L L ++ L WK RLR+ G AKG+ YLHE Sbjct: 791 VLLRGFCFYKNDRLLIYSYMENGSLDYWLHERNDGPALLKWKTRLRIAQGAAKGLLYLHE 850 Query: 362 LADPPIVHRDIKSSNVLLDERLNA 433 DP I+HRDIKSSN+LLDE N+ Sbjct: 851 GCDPHILHRDIKSSNILLDENFNS 874
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 135 bits (341), Expect = 3e-32 Identities = 67/139 (48%), Positives = 97/139 (69%), Gaps = 2/139 (1%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNV 187 T++FS+ N IG+GGFG VY+ L + VAVK+ E QG+ EF E+E L +V H N+ Sbjct: 914 TDHFSKKNIIGDGGFGTVYKACLPGEKTVAVKKLSEAKTQGNREFMAEMETLGKVKHPNL 973 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVR--LDWKRRLRVILGTAKGIAYLHE 361 VSL+G+C E++LVYEY+ NG+L L ++G+ LDW +RL++ +G A+G+A+LH Sbjct: 974 VSLLGYCSFSEEKLLVYEYMVNGSLDHWLRNQTGMLEVLDWSKRLKIAVGAARGLAFLHH 1033 Query: 362 LADPPIVHRDIKSSNVLLD 418 P I+HRDIK+SN+LLD Sbjct: 1034 GFIPHIIHRDIKASNILLD 1052
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 134 bits (337), Expect = 1e-31 Identities = 65/145 (44%), Positives = 98/145 (67%), Gaps = 2/145 (1%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNV 187 TN F + IG+GGFG VY+ L G VA+K+ S QG EF E+E + ++ H+N+ Sbjct: 880 TNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNL 939 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESL--TGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 V L+G+C E++LVYE++ G+L++ L K+GV+L+W R ++ +G+A+G+A+LH Sbjct: 940 VPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 999 Query: 362 LADPPIVHRDIKSSNVLLDERLNAK 436 P I+HRD+KSSNVLLDE L A+ Sbjct: 1000 NCSPHIIHRDMKSSNVLLDENLEAR 1024
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 134 bits (336), Expect = 1e-31 Identities = 67/148 (45%), Positives = 102/148 (68%), Gaps = 5/148 (3%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGS--LQGSLEFRTEIELLSRVHHK 181 T FSE + +G G F V++G L G +VAVKR+ + S + S EF E++LLSR++H Sbjct: 502 TGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKRAIKASDVKKSSKEFHNELDLLSRLNHA 561 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSG---VRLDWKRRLRVILGTAKGIAY 352 ++++L+G+C D E++LVYE++ +G+L + L GK RL+W RR+ + + A+GI Y Sbjct: 562 HLLNLLGYCEDGSERLLVYEFMAHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAARGIEY 621 Query: 353 LHELADPPIVHRDIKSSNVLLDERLNAK 436 LH A PP++HRDIKSSN+L+DE NA+ Sbjct: 622 LHGYACPPVIHRDIKSSNILIDEDHNAR 649
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 134 bits (336), Expect = 1e-31 Identities = 66/146 (45%), Positives = 98/146 (67%), Gaps = 3/146 (2%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNV 187 TN FS + IG+GGFG VY+ LA G +VA+K+ + + QG EF E+E + ++ H+N+ Sbjct: 855 TNGFSADSMIGSGGFGDVYKAKLADGSVVAIKKLIQVTGQGDREFMAEMETIGKIKHRNL 914 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESL---TGKSGVRLDWKRRLRVILGTAKGIAYLH 358 V L+G+C E++LVYEY+ G+L+ L T K G+ LDW R ++ +G A+G+A+LH Sbjct: 915 VPLLGYCKIGEERLLVYEYMKYGSLETVLHEKTKKGGIFLDWSARKKIAIGAARGLAFLH 974 Query: 359 ELADPPIVHRDIKSSNVLLDERLNAK 436 P I+HRD+KSSNVLLD+ A+ Sbjct: 975 HSCIPHIIHRDMKSSNVLLDQDFVAR 1000
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 133 bits (335), Expect = 2e-31 Identities = 64/145 (44%), Positives = 98/145 (67%), Gaps = 2/145 (1%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNV 187 TN F + +G+GGFG VY+ L G +VA+K+ S QG EF E+E + ++ H+N+ Sbjct: 885 TNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNL 944 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESL--TGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 V L+G+C E++LVYEY+ G+L++ L K+G++L+W R ++ +G A+G+A+LH Sbjct: 945 VPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKTGIKLNWPARRKIAIGAARGLAFLHH 1004 Query: 362 LADPPIVHRDIKSSNVLLDERLNAK 436 P I+HRD+KSSNVLLDE L A+ Sbjct: 1005 NCIPHIIHRDMKSSNVLLDENLEAR 1029
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 132 bits (332), Expect = 4e-31 Identities = 64/145 (44%), Positives = 97/145 (66%), Gaps = 2/145 (1%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNV 187 TN F + +G+GGFG VY+ L G +VA+K+ S QG EF E+E + ++ H+N+ Sbjct: 885 TNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNL 944 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESL--TGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 V L+G+C E++LVYEY+ G+L++ L K G++L+W R ++ +G A+G+A+LH Sbjct: 945 VPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKIGIKLNWPARRKIAIGAARGLAFLHH 1004 Query: 362 LADPPIVHRDIKSSNVLLDERLNAK 436 P I+HRD+KSSNVLLDE L A+ Sbjct: 1005 NCIPHIIHRDMKSSNVLLDENLEAR 1029
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 132 bits (331), Expect = 5e-31 Identities = 67/142 (47%), Positives = 94/142 (66%), Gaps = 2/142 (1%) Frame = +2 Query: 2 KITNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHK 181 K T++F++ N IG GGFG VY+ TL G VA+KR + Q EF+ E+E LSR H Sbjct: 738 KSTSSFNQANIIGCGGFGLVYKATLPDGTKVAIKRLSGDTGQMDREFQAEVETLSRAQHP 797 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGK--SGVRLDWKRRLRVILGTAKGIAYL 355 N+V L+G+C + +++L+Y Y+ NG+L L K LDWK RLR+ G A+G+AYL Sbjct: 798 NLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLHEKVDGPPSLDWKTRLRIARGAAEGLAYL 857 Query: 356 HELADPPIVHRDIKSSNVLLDE 421 H+ +P I+HRDIKSSN+LL + Sbjct: 858 HQSCEPHILHRDIKSSNILLSD 879
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 129 bits (324), Expect = 3e-30 Identities = 64/146 (43%), Positives = 97/146 (66%), Gaps = 1/146 (0%) Frame = +2 Query: 2 KITNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHK 181 K T NFS N +G GGFG VY+G L G+ +AVKR + S+QG+ EF E+ L++R+ H Sbjct: 523 KATENFSSCNKLGQGGFGIVYKGRLLDGKEIAVKRLSKTSVQGTDEFMNEVTLIARLQHI 582 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKS-GVRLDWKRRLRVILGTAKGIAYLH 358 N+V ++G C++ E+ML+YEY+ N +L L GK+ +L+W R + G A+G+ YLH Sbjct: 583 NLVQVLGCCIEGDEKMLIYEYLENLSLDSYLFGKTRRSKLNWNERFDITNGVARGLLYLH 642 Query: 359 ELADPPIVHRDIKSSNVLLDERLNAK 436 + + I+HRD+K SN+LLD+ + K Sbjct: 643 QDSRFRIIHRDLKVSNILLDKNMIPK 668
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 129 bits (323), Expect = 4e-30 Identities = 63/147 (42%), Positives = 96/147 (65%), Gaps = 4/147 (2%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNV 187 TN FS +G+GGFG+VY+ L G +VA+K+ + QG EF E+E + ++ H+N+ Sbjct: 856 TNGFSAETMVGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGDREFMAEMETIGKIKHRNL 915 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLK----ESLTGKSGVRLDWKRRLRVILGTAKGIAYL 355 V L+G+C E++LVYEY+ G+L+ E + K G+ L+W R ++ +G A+G+A+L Sbjct: 916 VPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFL 975 Query: 356 HELADPPIVHRDIKSSNVLLDERLNAK 436 H P I+HRD+KSSNVLLDE A+ Sbjct: 976 HHSCIPHIIHRDMKSSNVLLDEDFEAR 1002
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 129 bits (323), Expect = 4e-30 Identities = 65/147 (44%), Positives = 96/147 (65%), Gaps = 4/147 (2%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNV 187 TN FS + IG+GGFG+V++ TL G VA+K+ S QG EF E+E L ++ H+N+ Sbjct: 835 TNGFSAASMIGHGGFGEVFKATLKDGSSVAIKKLIRLSCQGDREFMAEMETLGKIKHRNL 894 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESL----TGKSGVRLDWKRRLRVILGTAKGIAYL 355 V L+G+C E++LVYE++ G+L+E L TG+ L W+ R ++ G AKG+ +L Sbjct: 895 VPLLGYCKIGEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFL 954 Query: 356 HELADPPIVHRDIKSSNVLLDERLNAK 436 H P I+HRD+KSSNVLLD+ + A+ Sbjct: 955 HHNCIPHIIHRDMKSSNVLLDQDMEAR 981
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 125 bits (313), Expect = 6e-29 Identities = 62/148 (41%), Positives = 93/148 (62%), Gaps = 5/148 (3%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLAT-GQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKN 184 T NF +G GGFGKV++GT+ Q+VA+K+ +QG EF E+ LS H N Sbjct: 100 TGNFRSDCFLGEGGFGKVFKGTIEKLDQVVAIKQLDRNGVQGIREFVVEVLTLSLADHPN 159 Query: 185 VVSLVGFCLDQGEQMLVYEYIPNGTLKESL----TGKSGVRLDWKRRLRVILGTAKGIAY 352 +V L+GFC + +++LVYEY+P G+L++ L +GK LDW R+++ G A+G+ Y Sbjct: 160 LVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHVLPSGKK--PLDWNTRMKIAAGAARGLEY 217 Query: 353 LHELADPPIVHRDIKSSNVLLDERLNAK 436 LH+ PP+++RD+K SN+LL E K Sbjct: 218 LHDRMTPPVIYRDLKCSNILLGEDYQPK 245
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 122 bits (305), Expect = 5e-28 Identities = 62/153 (40%), Positives = 98/153 (64%), Gaps = 10/153 (6%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRG-----TLA-----TGQLVAVKRSQEGSLQGSLEFRTEIE 157 T NF + +G GGFGKVYRG TLA +G +VA+KR S+QG E+R+E+ Sbjct: 83 TKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIKRLNSESVQGFAEWRSEVN 142 Query: 158 LLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTA 337 L + H+N+V L+G+C + E +LVYE++P G+L+ L ++ W R+++++G A Sbjct: 143 FLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRRND-PFPWDLRIKIVIGAA 201 Query: 338 KGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 +G+A+LH L +++RD K+SN+LLD +AK Sbjct: 202 RGLAFLHSL-QREVIYRDFKASNILLDSNYDAK 233
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 117 bits (294), Expect = 9e-27 Identities = 61/155 (39%), Positives = 92/155 (59%), Gaps = 12/155 (7%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTL----------ATGQLVAVKRSQEGSLQGSLEFRTEIE 157 T NF + +G GGFG V++G + TG ++AVK+ + QG E+ E+ Sbjct: 66 TRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPGTGVVIAVKKLNQDGWQGHQEWLAEVN 125 Query: 158 LLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESL--TGKSGVRLDWKRRLRVILG 331 L + H N+V L+G+CL+ ++LVYE++P G+L+ L G L W RL+V LG Sbjct: 126 YLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGSYFQPLSWTLRLKVALG 185 Query: 332 TAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 AKG+A+LH A+ +++RD K+SN+LLD NAK Sbjct: 186 AAKGLAFLHN-AETSVIYRDFKTSNILLDSEYNAK 219
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 117 bits (293), Expect = 1e-26 Identities = 61/155 (39%), Positives = 93/155 (60%), Gaps = 12/155 (7%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTL----------ATGQLVAVKRSQEGSLQGSLEFRTEIE 157 T NF + +G GGFG V++G + TG ++AVKR + QG E+ EI Sbjct: 65 TRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRLNQEGFQGHREWLAEIN 124 Query: 158 LLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESL--TGKSGVRLDWKRRLRVILG 331 L ++ H N+V L+G+CL++ ++LVYE++ G+L+ L G L W R+R+ LG Sbjct: 125 YLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFRRGTFYQPLSWNTRVRMALG 184 Query: 332 TAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A+G+A+LH A P +++RD K+SN+LLD NAK Sbjct: 185 AARGLAFLHN-AQPQVIYRDFKASNILLDSNYNAK 218
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 117 bits (292), Expect = 2e-26 Identities = 64/148 (43%), Positives = 89/148 (60%), Gaps = 5/148 (3%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSL---EFRTEIELLSRVHH 178 T NFSE IG GGFG VYR + + +E L+ ++ F TE+E LSR H Sbjct: 209 TCNFSEELRIGEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRH 268 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKES--LTGKSGVRLDWKRRLRVILGTAKGIAY 352 N+V G+C + G LVY ++PNG+L++ L ++ L W +RL ++LGTA+ I + Sbjct: 269 PNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQF 328 Query: 353 LHELADPPIVHRDIKSSNVLLDERLNAK 436 LH+ P ++H DIKSSNVLLDERL K Sbjct: 329 LHQ-DSPSLIHGDIKSSNVLLDERLMPK 355
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 117 bits (292), Expect = 2e-26 Identities = 60/138 (43%), Positives = 85/138 (61%), Gaps = 1/138 (0%) Frame = +2 Query: 23 EGNDIGNGGFGKVYRGTLATGQLVAVKRSQ-EGSLQGSLEFRTEIELLSRVHHKNVVSLV 199 E N IG GG G VYRG++ VA+KR G+ + F EI+ L R+ H+++V L+ Sbjct: 694 EENIIGKGGAGIVYRGSMPNNVDVAIKRLVGRGTGRSDHGFTAEIQTLGRIRHRHIVRLL 753 Query: 200 GFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPI 379 G+ ++ +L+YEY+PNG+L E L G G L W+ R RV + AKG+ YLH P I Sbjct: 754 GYVANKDTNLLLYEYMPNGSLGELLHGSKGGHLQWETRHRVAVEAAKGLCYLHHDCSPLI 813 Query: 380 VHRDIKSSNVLLDERLNA 433 +HRD+KS+N+LLD A Sbjct: 814 LHRDVKSNNILLDSDFEA 831
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 117 bits (292), Expect = 2e-26 Identities = 68/157 (43%), Positives = 90/157 (57%), Gaps = 12/157 (7%) Frame = +2 Query: 2 KITNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLE----------FRTE 151 +I + E N IG G GKVY+ L G++VAVK+ + G E F E Sbjct: 678 EIADCLDEKNVIGFGSSGKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAE 737 Query: 152 IELLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTG--KSGVRLDWKRRLRVI 325 +E L + HK++V L C ++LVYEY+PNG+L + L G K GV L W RLR+ Sbjct: 738 VETLGTIRHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKGGVVLGWPERLRIA 797 Query: 326 LGTAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 L A+G++YLH PPIVHRD+KSSN+LLD AK Sbjct: 798 LDAAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAK 834
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 116 bits (291), Expect = 2e-26 Identities = 67/149 (44%), Positives = 90/149 (60%), Gaps = 6/149 (4%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGS----LQGSLEFRTEIELLSRVH 175 T+NFSE IG GGFG VYR + + AVKR +E + F TE+E LSR Sbjct: 209 THNFSEELKIGEGGFGCVYRAVMRN-TVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFR 267 Query: 176 HKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGV--RLDWKRRLRVILGTAKGIA 349 H N+V G+C G LVY ++PNG+L++ L ++ L W +RL ++LGTA+ I Sbjct: 268 HPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQ 327 Query: 350 YLHELADPPIVHRDIKSSNVLLDERLNAK 436 +LH+ P ++H DIKSSNVLLDERL K Sbjct: 328 FLHQ-DSPSLIHGDIKSSNVLLDERLTPK 355
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 115 bits (289), Expect = 4e-26 Identities = 60/155 (38%), Positives = 94/155 (60%), Gaps = 12/155 (7%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTL----------ATGQLVAVKRSQEGSLQGSLEFRTEIE 157 T NF + +G GGFG V++G + TG ++AVK+ + QG E+ E+ Sbjct: 65 TRNFRPDSVLGEGGFGCVFKGWIDEKSLTASRPGTGLVIAVKKLNQDGWQGHQEWLAEVN 124 Query: 158 LLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESL--TGKSGVRLDWKRRLRVILG 331 L + H+++V L+G+CL+ ++LVYE++P G+L+ L G L WK RL+V LG Sbjct: 125 YLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGLYFQPLSWKLRLKVALG 184 Query: 332 TAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 AKG+A+LH ++ +++RD K+SN+LLD NAK Sbjct: 185 AAKGLAFLHS-SETRVIYRDFKTSNILLDSEYNAK 218
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 104 bits (260), Expect = 8e-23 Identities = 53/136 (38%), Positives = 81/136 (59%), Gaps = 1/136 (0%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 ++G G G VY+G L + VAVK+ E QG F+ E+ ++ R++H N+V + GFC Sbjct: 539 ELGRGESGTVYKGVLEDDRHVAVKKL-ENVRQGKEVFQAELSVIGRINHMNLVRIWGFCS 597 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSG-VRLDWKRRLRVILGTAKGIAYLHELADPPIVHR 388 + ++LV EY+ NG+L L + G + LDW+ R + LG AKG+AYLH ++H Sbjct: 598 EGSHRLLVSEYVENGSLANILFSEGGNILLDWEGRFNIALGVAKGLAYLHHECLEWVIHC 657 Query: 389 DIKSSNVLLDERLNAK 436 D+K N+LLD+ K Sbjct: 658 DVKPENILLDQAFEPK 673
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 103 bits (258), Expect = 1e-22 Identities = 64/155 (41%), Positives = 90/155 (58%), Gaps = 11/155 (7%) Frame = +2 Query: 5 ITNNFSE------GNDIGNGGFGKVYRGTLATGQLVAVKRS----QEGSLQGSLEFRTEI 154 ITNNF E GN +G GGFG VY+G + +VAVK+ + + + +F EI Sbjct: 176 ITNNFDEQPASAGGNRMGEGGFGVVYKGCV-NNTIVAVKKLGAMVEISTEELKQQFDQEI 234 Query: 155 ELLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGV-RLDWKRRLRVILG 331 ++++ H+N+V L+GF D LVY Y+PNG+L + L+ G L W R +V G Sbjct: 235 KVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTPPLSWHTRCKVAQG 294 Query: 332 TAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 TA GI +LHE +HRDIKS+N+LLD+ AK Sbjct: 295 TANGIRFLHENHH---IHRDIKSANILLDKDFTAK 326
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 103 bits (256), Expect = 2e-22 Identities = 63/156 (40%), Positives = 90/156 (57%), Gaps = 12/156 (7%) Frame = +2 Query: 5 ITNNFSE------GNDIGNGGFGKVYRG-----TLATGQLVAVKRSQEGSLQGSLEFRTE 151 +TNNF E GN +G GGFG VY+G T+A +L A+ L+ +F E Sbjct: 176 VTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQ--QFDQE 233 Query: 152 IELLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGV-RLDWKRRLRVIL 328 I+++++ H+N+V L+GF D + LVY Y+PNG+L + L+ G L W R ++ Sbjct: 234 IKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQ 293 Query: 329 GTAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 G A GI +LHE +HRDIKS+N+LLDE AK Sbjct: 294 GAANGINFLHENHH---IHRDIKSANILLDEAFTAK 326
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 101 bits (251), Expect = 9e-22 Identities = 56/142 (39%), Positives = 83/142 (58%), Gaps = 2/142 (1%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQ-EGSLQGSLEFRTEIELLSRVHHKN 184 T N ++ IG G G +Y+ TL+ ++ AVK+ G GS+ EIE + +V H+N Sbjct: 813 TENLNDKYVIGKGAHGTIYKATLSPDKVYAVKKLVFTGIKNGSVSMVREIETIGKVRHRN 872 Query: 185 VVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVR-LDWKRRLRVILGTAKGIAYLHE 361 ++ L F L + +++Y Y+ NG+L + L + + LDW R + +GTA G+AYLH Sbjct: 873 LIKLEEFWLRKEYGLILYTYMENGSLHDILHETNPPKPLDWSTRHNIAVGTAHGLAYLHF 932 Query: 362 LADPPIVHRDIKSSNVLLDERL 427 DP IVHRDIK N+LLD L Sbjct: 933 DCDPAIVHRDIKPMNILLDSDL 954
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 92.8 bits (229), Expect = 3e-19 Identities = 54/144 (37%), Positives = 84/144 (58%), Gaps = 2/144 (1%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGS--LEFRTEIELLSRVHHKN 184 + S G IG G +G V+ G G VAVK+ + L + LEFR E+ LS + H N Sbjct: 1362 DEISIGKQIGLGSYGIVFNGKWK-GVDVAVKKFVKQKLSETQLLEFRAEMAFLSELKHSN 1420 Query: 185 VVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHEL 364 +V+ +G C+ + +V EY+ G L++ L +++ + +L+++ G A GI YLH Sbjct: 1421 IVTFIGACIKKPNICIVTEYMRMGNLRDVLKNPD-IKITFANKLKLLYGAAMGIDYLHS- 1478 Query: 365 ADPPIVHRDIKSSNVLLDERLNAK 436 ++P IVHRDIK +N+L+DE N K Sbjct: 1479 SNPMIVHRDIKPANILVDEHFNVK 1502 Score = 68.2 bits (165), Expect = 9e-12 Identities = 44/146 (30%), Positives = 78/146 (53%), Gaps = 5/146 (3%) Frame = +2 Query: 14 NFSE---GNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLE--FRTEIELLSRVHH 178 +FSE G +G GG+G+VY+ ++ G VAVK + +E F E+++++ + H Sbjct: 782 DFSELEIGETLGTGGYGEVYK-SIWKGTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRH 840 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLH 358 NVV + +V E++ G+L + L + + + ++++ +KG+ +LH Sbjct: 841 PNVVLFMAASTKSPNMCIVMEFMSLGSLYDLLGNELIPEIPYALKIKMAYQASKGMHFLH 900 Query: 359 ELADPPIVHRDIKSSNVLLDERLNAK 436 IVHRD+KS N+LLD + N K Sbjct: 901 SSG---IVHRDLKSLNLLLDSKWNVK 923
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 88.2 bits (217), Expect = 8e-18 Identities = 55/154 (35%), Positives = 85/154 (55%), Gaps = 11/154 (7%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQL-VAVKRSQEGSL---QGSLEFR---TEIELLS 166 T+ +S N +G GGFG VYRG QL VA+K S Q +E + E++ L+ Sbjct: 210 TDGWSPDNRLGQGGFGDVYRGKWK--QLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLN 267 Query: 167 RVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVR----LDWKRRLRVILGT 334 + H N+++L G+ + G+ LVY+ + G+L+ L L W++R + LGT Sbjct: 268 SIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGT 327 Query: 335 AKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A+GI +LH P++H DIK +N+LLD+ L K Sbjct: 328 ARGIYFLHTARGTPLIHGDIKPANILLDQCLQPK 361
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 86.7 bits (213), Expect = 2e-17 Identities = 46/127 (36%), Positives = 78/127 (61%), Gaps = 3/127 (2%) Frame = +2 Query: 50 FGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLDQ-GEQ 226 +G VY+ L+ G +A++ +EG+ + I L R+ H+N+V L F + GE+ Sbjct: 384 YGTVYKAKLSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRAFYQGKRGEK 443 Query: 227 MLVYEYIPNGTLKESLTGKSGVR--LDWKRRLRVILGTAKGIAYLHELADPPIVHRDIKS 400 +L+Y+Y+PN +L + L + L+W RR ++ LG A+G+AYLH + PI+H +I+S Sbjct: 444 LLIYDYLPNISLHDLLHESKPRKPALNWARRHKIALGIARGLAYLHTGQEVPIIHGNIRS 503 Query: 401 SNVLLDE 421 NVL+D+ Sbjct: 504 KNVLVDD 510
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 86.7 bits (213), Expect = 2e-17 Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 4/147 (2%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVK-RSQEGSLQGSLE--FRTEIELLSRVHH 178 T++F++ I G F VYRG V K R S GS+E F+ E+++ R H Sbjct: 207 TDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCH 266 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGV-RLDWKRRLRVILGTAKGIAYL 355 NV+ ++GFC + +Y Y+ NG+L++ L G+ G L W +R+ + G + YL Sbjct: 267 PNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYL 326 Query: 356 HELADPPIVHRDIKSSNVLLDERLNAK 436 H L I+H ++KSSNVLLD+ L K Sbjct: 327 HGL---EIIHSNVKSSNVLLDQNLTPK 350
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 84.3 bits (207), Expect = 1e-16 Identities = 57/147 (38%), Positives = 77/147 (52%), Gaps = 16/147 (10%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSL----EFRTEIELLSRVHHKNVVSLVG 202 IG GGFG+VYR T GQ VAVK +++ Q + R E L + + H N++ L G Sbjct: 130 IGAGGFGQVYRATWQ-GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRG 188 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGV---RLDWKRRLRVI---------LGTAKGI 346 CL Q LV E+ G L +L + R RR R I + A+G+ Sbjct: 189 VCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGM 248 Query: 347 AYLHELADPPIVHRDIKSSNVLLDERL 427 YLHE A PI+HRD+KSSN+LL E++ Sbjct: 249 LYLHEEAFVPILHRDLKSSNILLLEKI 275
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 81.6 bits (200), Expect = 8e-16 Identities = 51/133 (38%), Positives = 77/133 (57%), Gaps = 4/133 (3%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLE---FRTEIELLSRVHHKNVVSLVGF 205 IG+G FGKVY+G ++VA+KR + + + F E+ +L +++H VV VG Sbjct: 467 IGSGSFGKVYKGR-CRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGA 525 Query: 206 CLDQGEQM-LVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 CLD Q +V +YI G+L L + + LD + +L + + AKG+ YLH L PI+ Sbjct: 526 CLDDPSQFAIVTQYISGGSLFSLLHEQKRI-LDLQSKLIIAVDVAKGMEYLHSLTQ-PII 583 Query: 383 HRDIKSSNVLLDE 421 HRD+ S N+LL E Sbjct: 584 HRDLNSHNILLYE 596
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 81.6 bits (200), Expect = 8e-16 Identities = 55/138 (39%), Positives = 74/138 (53%), Gaps = 4/138 (2%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSL--EFRTEIELLSRVHHKNVVSLVGFC 208 IG G FG V+R G VAVK E EF E+ ++ R+ H N+V +G Sbjct: 557 IGAGSFGTVHRAEWH-GSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAV 615 Query: 209 LDQGEQMLVYEYIPNGTLKESLTGKSGVR--LDWKRRLRVILGTAKGIAYLHELADPPIV 382 +V EY+ G+L L KSG R LD +RRL + AKG+ YLH +PPIV Sbjct: 616 TQPPNLSIVTEYLSRGSLYR-LLHKSGAREQLDERRRLSMAYDVAKGMNYLHN-RNPPIV 673 Query: 383 HRDIKSSNVLLDERLNAK 436 HRD+KS N+L+D++ K Sbjct: 674 HRDLKSPNLLVDKKYTVK 691
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 81.6 bits (200), Expect = 8e-16 Identities = 51/133 (38%), Positives = 77/133 (57%), Gaps = 4/133 (3%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLE---FRTEIELLSRVHHKNVVSLVGF 205 IG+G FGKVY+G ++VA+KR + + + F E+ +L +++H VV VG Sbjct: 468 IGSGSFGKVYKGR-CRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGA 526 Query: 206 CLDQGEQM-LVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 CLD Q +V +YI G+L L + + LD + +L + + AKG+ YLH L PI+ Sbjct: 527 CLDDPSQFAIVTQYISGGSLFSLLHEQKRI-LDLQSKLIIAVDVAKGMEYLHSLTQ-PII 584 Query: 383 HRDIKSSNVLLDE 421 HRD+ S N+LL E Sbjct: 585 HRDLNSHNILLYE 597
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 80.9 bits (198), Expect = 1e-15 Identities = 50/134 (37%), Positives = 77/134 (57%), Gaps = 7/134 (5%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQG----SLEFRTEIELLSRVHHKNVVSLVG 202 IG GGFGKVYRG+ G+LVAVK +++ + + R E L + + H N+++L Sbjct: 123 IGIGGFGKVYRGSWR-GELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKA 181 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGK---SGVRLDWKRRLRVILGTAKGIAYLHELADP 373 CL++ LV EY G L +L G+ V ++W ++ A+G+ YLH A Sbjct: 182 VCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQI------ARGMHYLHCEALV 235 Query: 374 PIVHRDIKSSNVLL 415 P++HRD+KS+N+LL Sbjct: 236 PVIHRDLKSNNILL 249
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 79.3 bits (194), Expect = 4e-15 Identities = 49/133 (36%), Positives = 77/133 (57%), Gaps = 4/133 (3%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLE---FRTEIELLSRVHHKNVVSLVGF 205 IG+G FGKVY+G ++VA+KR + + + F E+ +L +++H V+ VG Sbjct: 570 IGSGSFGKVYKGR-CRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGA 628 Query: 206 CLDQGEQM-LVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 CL+ Q +V +YI G+L L + + LD + +L + + AKG+ YLH L PI+ Sbjct: 629 CLNDPSQFAIVTQYISGGSLFSLLHEQKRI-LDLQSKLIIAVDVAKGMEYLHNLTQ-PII 686 Query: 383 HRDIKSSNVLLDE 421 HRD+ S N+LL E Sbjct: 687 HRDLNSHNILLYE 699
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 79.3 bits (194), Expect = 4e-15 Identities = 54/148 (36%), Positives = 80/148 (54%), Gaps = 6/148 (4%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGTLATGQLVAVK---RSQEGSLQGSLEFRTEIELLSRVHHK 181 N G IG G FG+V RG VA+K R Q + + F+ E+ +LS++ H Sbjct: 1287 NELEFGQTIGKGFFGEVKRGYWRETD-VAIKIIYRDQFKTKSSLVMFQNEVGILSKLRHP 1345 Query: 182 NVVSLVGFCLDQGEQ--MLVYEYIPNGTLKESLTGKSGV-RLDWKRRLRVILGTAKGIAY 352 NVV +G C GE +V E++ G+L++ LT + + RL++ L AKG+ Y Sbjct: 1346 NVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPHIRLKLALDIAKGMNY 1405 Query: 353 LHELADPPIVHRDIKSSNVLLDERLNAK 436 LH PPI+HRD+ S N+LLD ++ K Sbjct: 1406 LHGWT-PPILHRDLSSRNILLDHNIDPK 1432
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 79.3 bits (194), Expect = 4e-15 Identities = 51/138 (36%), Positives = 77/138 (55%), Gaps = 7/138 (5%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQ----EGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 IG GGFGKVYR G VAVK ++ E Q R E +L + + H N+++L G Sbjct: 150 IGIGGFGKVYRA-FWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRG 208 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKS---GVRLDWKRRLRVILGTAKGIAYLHELADP 373 CL + LV E+ G L L+GK + ++W ++ A+G+ YLH+ A Sbjct: 209 VCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQI------ARGMNYLHDEAIV 262 Query: 374 PIVHRDIKSSNVLLDERL 427 PI+HRD+KSSN+L+ +++ Sbjct: 263 PIIHRDLKSSNILILQKV 280
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 76.6 bits (187), Expect = 2e-14 Identities = 44/143 (30%), Positives = 75/143 (52%), Gaps = 6/143 (4%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTLATGQLVAVK------RSQEGSLQGSLEFRTEIELLSRVHHKNV 187 GN +G ++YRG + + VAVK +E + +F++E+ LLSR+ H N+ Sbjct: 89 GNKFASGAHSRIYRG-IYKQRAVAVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNI 147 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELA 367 V + C ++ EY+ G L+ L K L + LR+ L ++G+ YLH Sbjct: 148 VQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQG 207 Query: 368 DPPIVHRDIKSSNVLLDERLNAK 436 ++HRD+KS+N+LL++ + K Sbjct: 208 ---VIHRDLKSNNLLLNDEMRVK 227
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 76.3 bits (186), Expect = 3e-14 Identities = 50/143 (34%), Positives = 81/143 (56%), Gaps = 8/143 (5%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLA----TGQLVAVKRSQEG-SLQGSLEFRTEIELLSRVHHKNVVSL 196 ++G G FGKVY+G L T VA+K +E S++ +F+ EIEL+S + H+N+V + Sbjct: 415 ELGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCI 474 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLTGKS---GVRLDWKRRLRVILGTAKGIAYLHELA 367 +G L++ +++EY+ NG L E L S G L L++ L ++G+ Y L+ Sbjct: 475 LGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQIALQISEGMQY---LS 531 Query: 368 DPPIVHRDIKSSNVLLDERLNAK 436 VHRD+ + N L++E L K Sbjct: 532 AHHYVHRDLAARNCLVNEGLVVK 554
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 74.7 bits (182), Expect = 9e-14 Identities = 47/141 (33%), Positives = 79/141 (56%), Gaps = 8/141 (5%) Frame = +2 Query: 17 FSEGNDIGNGGFGKVYRGTLATGQLVAVKR---SQEGSLQGSLEFRT---EIELLSRVHH 178 +++G +G G +G VY G + GQL+AVK+ L E+R E++LL + H Sbjct: 1061 WTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKH 1120 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSG--VRLDWKRRLRVILGTAKGIAY 352 N+V+ +G CL + + E++P G++ S+ + G + + + + IL +G+AY Sbjct: 1121 VNIVAYLGTCLQENTVSIFMEFVPGGSI-SSIINRFGPLPEMVFCKYTKQIL---QGVAY 1176 Query: 353 LHELADPPIVHRDIKSSNVLL 415 LHE +VHRDIK +NV+L Sbjct: 1177 LHENC---VVHRDIKGNNVML 1194
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 73.9 bits (180), Expect = 2e-13 Identities = 50/138 (36%), Positives = 73/138 (52%), Gaps = 7/138 (5%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRS----QEGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 IG GGFGKVYR L G+ VAVK + ++ + + E L + H N+++L G Sbjct: 104 IGVGGFGKVYRA-LWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRG 162 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKS---GVRLDWKRRLRVILGTAKGIAYLHELADP 373 CL+ LV EY G L L G+ V ++W ++ A+G+ YLH A Sbjct: 163 ACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQV------ARGMNYLHNDAPV 216 Query: 374 PIVHRDIKSSNVLLDERL 427 PI+HRD+KS N+L+ E + Sbjct: 217 PIIHRDLKSINILILEAI 234
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 73.2 bits (178), Expect = 3e-13 Identities = 40/138 (28%), Positives = 74/138 (53%), Gaps = 2/138 (1%) Frame = +2 Query: 29 NDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFC 208 N+IG G FG V+R VA K Q + +F E +++ ++ H+ +V L+G C Sbjct: 224 NEIGRGFFGSVHRAKWGRSYEVAAKMLQSSKAERE-KFVLEAKIMHKLRHRKIVELLGVC 282 Query: 209 LDQGEQ--MLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 + + +++ EY+ NG+LKE L G + + + + ++ ++G+AYL +V Sbjct: 283 TEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEISEGMAYLE---SEKVV 339 Query: 383 HRDIKSSNVLLDERLNAK 436 HRD+++ N+L+ L K Sbjct: 340 HRDLRADNILVANDLTRK 357
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 72.0 bits (175), Expect = 6e-13 Identities = 43/131 (32%), Positives = 71/131 (54%), Gaps = 1/131 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G +G G FG+ + T ATG+++ +K + F TE++++ + H NV+ +G Sbjct: 334 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIG 393 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 + L+ EYI GTLK+ L +S W++++R G A G+AYLH + I+ Sbjct: 394 VLYKDKKLNLLTEYIEGGTLKDFL--RSMDPFPWQQKVRFAKGIASGMAYLHSMC---II 448 Query: 383 HRDIKSSNVLL 415 HRD+ S N L+ Sbjct: 449 HRDLNSHNCLI 459
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 72.0 bits (175), Expect = 6e-13 Identities = 49/148 (33%), Positives = 77/148 (52%), Gaps = 5/148 (3%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKR-SQEGSLQGSLE---FRTEIELLSRVH 175 T +F + IG G +VYR + Q AVK QE +Q F +E+E+L Sbjct: 175 TKHFHKDFLIGEGEIFEVYRVDIRN-QAYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFR 233 Query: 176 HKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVR-LDWKRRLRVILGTAKGIAY 352 H +++ L + + + LVY Y+ NGTL + L +G L W R+ V++G AK I Y Sbjct: 234 HPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGIAKAIQY 293 Query: 353 LHELADPPIVHRDIKSSNVLLDERLNAK 436 LH ++ ++ S+N+LLD++L K Sbjct: 294 LHNTQPCAVICGNVSSANILLDDQLQPK 321
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 71.6 bits (174), Expect = 8e-13 Identities = 44/136 (32%), Positives = 77/136 (56%), Gaps = 1/136 (0%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNV 187 ++F IG G F +VY+ +GQ++ +K ++ S +G+ E++L++R+ H N+ Sbjct: 55 DDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNT--LREVQLMNRLRHPNI 112 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELA 367 + +G C+ QG+ + EY+ GTL++ L+ S L W RL + L A+G+ YLH Sbjct: 113 LRFMGVCVHQGQLHALTEYMNGGTLEQLLS--SPEPLSWPVRLHLALDIARGLRYLHSKG 170 Query: 368 DPPIVHRDIKSSNVLL 415 + HRD+ S N L+ Sbjct: 171 ---VFHRDLTSKNCLV 183
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 71.2 bits (173), Expect = 1e-12 Identities = 48/142 (33%), Positives = 78/142 (54%), Gaps = 7/142 (4%) Frame = +2 Query: 32 DIGNGGFGKV----YRGTLATGQLVAVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSL 196 D+G G FGKV Y TG+ VAVK + S + + + EIE+L ++H+N+V Sbjct: 869 DLGEGHFGKVELCRYDPEDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKY 928 Query: 197 VGFCLDQGEQ--MLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELAD 370 G C + G L+ E++P+G+LKE L K+ +++ K++L+ + KG+ Y L Sbjct: 929 KGICTEDGGNGIKLIMEFLPSGSLKEYLP-KNKNKINLKQQLKYAVQICKGMDY---LGS 984 Query: 371 PPIVHRDIKSSNVLLDERLNAK 436 VHRD+ + NVL++ K Sbjct: 985 RQYVHRDLAARNVLVESEHQVK 1006 Score = 46.6 bits (109), Expect = 3e-05 Identities = 39/143 (27%), Positives = 63/143 (44%), Gaps = 12/143 (8%) Frame = +2 Query: 23 EGNDIGNGGFGKVYRGTLATGQ-----------LVAVKRSQEGSLQGSLEFRTEIELLSR 169 +G +G G +Y GTL + V +K SL F ++ + Sbjct: 573 QGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQ 632 Query: 170 VHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGV-RLDWKRRLRVILGTAKGI 346 V HK++V L G C+ E ++V E++ G L + KS V WK ++ L +A Sbjct: 633 VSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASA--- 689 Query: 347 AYLHELADPPIVHRDIKSSNVLL 415 L L D +VH ++ + N+LL Sbjct: 690 --LSYLEDKDLVHGNVCTKNLLL 710
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 70.9 bits (172), Expect = 1e-12 Identities = 44/127 (34%), Positives = 72/127 (56%), Gaps = 4/127 (3%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLE---FRTEIELLSRVHHKNVVSLVGF 205 IG+G FGKVY+G ++VA+KR + + + F E+ +L +++H V+ VG Sbjct: 468 IGSGSFGKVYKGR-CRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGA 526 Query: 206 CLDQGEQM-LVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 CL+ Q +V +YI G+L L + + LD + +L + + A+G+ YLH L PI+ Sbjct: 527 CLNDPSQFAIVTQYISGGSLFSLLHEQKRI-LDLQSKLIIAVDVARGMEYLHNLTQ-PII 584 Query: 383 HRDIKSS 403 HRD+ S Sbjct: 585 HRDLNRS 591
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 70.9 bits (172), Expect = 1e-12 Identities = 43/145 (29%), Positives = 77/145 (53%), Gaps = 2/145 (1%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGS--LQGSLEFRTEIELLSRVHHK 181 +++F E ++ +GGFGKV T L+ +K +G ++ + E ++++R+ H Sbjct: 14 SSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHS 73 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 VV L+G +++G+ LV EY+ G L L + L K R +IL +G+ YLH Sbjct: 74 RVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGR--IILEIIEGMCYLHG 131 Query: 362 LADPPIVHRDIKSSNVLLDERLNAK 436 ++H+D+K N+L+D + K Sbjct: 132 KG---VIHKDLKPENILVDNDFHIK 153
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 70.9 bits (172), Expect = 1e-12 Identities = 42/131 (32%), Positives = 71/131 (54%), Gaps = 1/131 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G +G G FG+ + T ATG+++ +K + F TE++++ + H NV+ +G Sbjct: 334 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIG 393 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 + L+ EYI GTLK+ L ++ W++++R G A G+AYLH + I+ Sbjct: 394 VLYKDKKLNLLTEYIEGGTLKDFL--RNVDPFPWQQKVRFAKGIASGMAYLHSMC---II 448 Query: 383 HRDIKSSNVLL 415 HRD+ S N L+ Sbjct: 449 HRDLNSHNCLI 459
>LIMK2_MOUSE (O54785) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 70.9 bits (172), Expect = 1e-12 Identities = 42/131 (32%), Positives = 71/131 (54%), Gaps = 1/131 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G +G G FG+ + T ATG+++ +K + F TE++++ + H NV+ +G Sbjct: 334 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIG 393 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 + L+ EYI GTLK+ L +S W++++R G + G+AYLH + I+ Sbjct: 394 VLYKDKKLNLLTEYIEGGTLKDFL--RSVDPFPWQQKVRFAKGISSGMAYLHSMC---II 448 Query: 383 HRDIKSSNVLL 415 HRD+ S N L+ Sbjct: 449 HRDLNSHNCLI 459
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 70.9 bits (172), Expect = 1e-12 Identities = 42/130 (32%), Positives = 72/130 (55%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 +IG+G FG V+ G VA+K QEG++ +F E E++ ++ H +V L G CL Sbjct: 373 EIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEE-DFIEEAEVMMKLSHPKLVQLYGVCL 431 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRD 391 +Q LV+E++ +G L + L + G+ + L + L +G+AYL + ++HRD Sbjct: 432 EQAPICLVFEFMEHGCLSDYLRSQRGL-FAAETLLGMCLDVCEGMAYLEKAC---VIHRD 487 Query: 392 IKSSNVLLDE 421 + + N L+ E Sbjct: 488 LAARNCLVGE 497
>LIMK1_DROME (Q8IR79) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (dLIMK)| Length = 1257 Score = 70.5 bits (171), Expect = 2e-12 Identities = 41/133 (30%), Positives = 71/133 (53%), Gaps = 1/133 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G +G G FGKV++ T +G+++ +K + F E+ +L + H++V+ +G Sbjct: 404 GEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIG 463 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 + +V EY+ G LKE + + V L W +R+R+ A G++YLH + I+ Sbjct: 464 VLYKDKKLHMVTEYVAGGCLKELIHDPAQV-LPWPQRVRLARDIACGMSYLHSM---NII 519 Query: 383 HRDIKSSNVLLDE 421 HRD+ S N L+ E Sbjct: 520 HRDLNSMNCLVRE 532
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 70.5 bits (171), Expect = 2e-12 Identities = 50/137 (36%), Positives = 74/137 (54%), Gaps = 6/137 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRT----EIELLSRVHHKNVVSLVG 202 IG+GGF KV+RG G+ VA+K + + R E +L + H+N+ +L G Sbjct: 148 IGSGGFCKVHRGYY-DGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRG 206 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGK--SGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 CL+ + LV EY G+L L GK V ++W ++ A+G+ YLH A Sbjct: 207 VCLNT-KLCLVMEYARGGSLNRILAGKIPPDVLVNWAIQI------ARGMNYLHNEAPMS 259 Query: 377 IVHRDIKSSNVLLDERL 427 I+HRD+KSSNVL+ E + Sbjct: 260 IIHRDLKSSNVLIYEAI 276
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 70.1 bits (170), Expect = 2e-12 Identities = 45/141 (31%), Positives = 71/141 (50%), Gaps = 7/141 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLA-----TGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLV 199 +G G FG V TG++VAVK+ Q + + +F EIE+L + H N+V Sbjct: 855 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 914 Query: 200 GFCLDQGEQ--MLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADP 373 G C G + L+ EY+P G+L++ L K R+D K+ L+ KG+ Y L Sbjct: 915 GVCYSAGRRNLRLIMEYLPYGSLRDYLQ-KHKERIDHKKLLQYTSQICKGMEY---LGTK 970 Query: 374 PIVHRDIKSSNVLLDERLNAK 436 +HRD+ + N+L++ K Sbjct: 971 RYIHRDLATRNILVENENRVK 991 Score = 52.0 bits (123), Expect = 6e-07 Identities = 39/137 (28%), Positives = 69/137 (50%), Gaps = 10/137 (7%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT----GQL----VAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVV 190 +G G F K+++G GQL V +K + S F ++S++ HK++V Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLV 610 Query: 191 SLVGFCLDQGEQMLVYEYIPNGTLKESL-TGKSGVRLDWKRRLRVILGTAKGIAY-LHEL 364 G C+ E +LV E++ G+L L K+ + + WK LG AK +A+ +H L Sbjct: 611 LNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWK------LGVAKQLAWAMHFL 664 Query: 365 ADPPIVHRDIKSSNVLL 415 + ++H ++ + N+LL Sbjct: 665 EEKSLIHGNVCAKNILL 681
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 70.1 bits (170), Expect = 2e-12 Identities = 45/141 (31%), Positives = 71/141 (50%), Gaps = 7/141 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLA-----TGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLV 199 +G G FG V TG++VAVK+ Q + + +F EIE+L + H N+V Sbjct: 855 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 914 Query: 200 GFCLDQGEQ--MLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADP 373 G C G + L+ EY+P G+L++ L K R+D K+ L+ KG+ Y L Sbjct: 915 GVCYSAGRRNLRLIMEYLPYGSLRDYLQ-KHKERIDHKKLLQYTSQICKGMEY---LGTK 970 Query: 374 PIVHRDIKSSNVLLDERLNAK 436 +HRD+ + N+L++ K Sbjct: 971 RYIHRDLATRNILVENENRVK 991 Score = 52.0 bits (123), Expect = 6e-07 Identities = 39/137 (28%), Positives = 69/137 (50%), Gaps = 10/137 (7%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT----GQL----VAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVV 190 +G G F K+++G GQL V +K + S F ++S++ HK++V Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLV 610 Query: 191 SLVGFCLDQGEQMLVYEYIPNGTLKESL-TGKSGVRLDWKRRLRVILGTAKGIAY-LHEL 364 G C+ E +LV E++ G+L L K+ + + WK LG AK +A+ +H L Sbjct: 611 LNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWK------LGVAKQLAWAMHFL 664 Query: 365 ADPPIVHRDIKSSNVLL 415 + ++H ++ + N+LL Sbjct: 665 EEKSLIHGNVCAKNILL 681
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 70.1 bits (170), Expect = 2e-12 Identities = 42/130 (32%), Positives = 72/130 (55%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 +IG+G FG V+ G VA+K +EG++ +F E E++ ++ H +V L G CL Sbjct: 368 EIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEE-DFIEEAEVMMKLSHPKLVQLYGVCL 426 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRD 391 +Q LV+E++ +G L + L + G+ + L + L +G+AYL E ++HRD Sbjct: 427 EQAPICLVFEFMEHGCLSDYLRTQRGL-FAAETLLGMCLDVCEGMAYLEEAC---VIHRD 482 Query: 392 IKSSNVLLDE 421 + + N L+ E Sbjct: 483 LAARNCLVGE 492
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 70.1 bits (170), Expect = 2e-12 Identities = 44/147 (29%), Positives = 71/147 (48%), Gaps = 4/147 (2%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLE---FRTEIELLSRVHH 178 T NF + IG G +VYR + QE +Q F +E+E+L HH Sbjct: 162 TRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHH 221 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVR-LDWKRRLRVILGTAKGIAYL 355 N++ L + + + L+Y Y+ NGTL + L L W R+ +++G +K I YL Sbjct: 222 PNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYL 281 Query: 356 HELADPPIVHRDIKSSNVLLDERLNAK 436 H + ++ I S+N+LLD++ K Sbjct: 282 HNVQPCSVICGSISSANILLDDQFQPK 308
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 70.1 bits (170), Expect = 2e-12 Identities = 42/128 (32%), Positives = 76/128 (59%), Gaps = 1/128 (0%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 IG+G F +V++ A+GQ++A+K + S + ++ E++L++R+ H N++ +G C+ Sbjct: 64 IGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANM--LKEVQLMNRLSHPNILRFMGVCV 121 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRD 391 QG+ + EYI +G L++ L S + L W R+++ A G++YLH I HRD Sbjct: 122 HQGQLHALTEYINSGNLEQLL--DSNLHLPWTVRVKLAYDIAVGLSYLHFKG---IFHRD 176 Query: 392 IKSSNVLL 415 + S N L+ Sbjct: 177 LTSKNCLI 184
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 69.7 bits (169), Expect = 3e-12 Identities = 47/143 (32%), Positives = 78/143 (54%), Gaps = 8/143 (5%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLA-----TGQLVAVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVS 193 D+G G FGKV TG+ VAVK + S + + + EIE+L ++H+N+V Sbjct: 879 DLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVK 938 Query: 194 LVGFCLDQGEQ--MLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELA 367 G C++ G L+ E++P+G+LKE L K+ +++ K++L+ + KG+ Y L Sbjct: 939 YKGICMEDGGNGIKLIMEFLPSGSLKEYLP-KNKNKINLKQQLKYAIQICKGMDY---LG 994 Query: 368 DPPIVHRDIKSSNVLLDERLNAK 436 VHRD+ + NVL++ K Sbjct: 995 SRQYVHRDLAARNVLVESEHQVK 1017 Score = 45.8 bits (107), Expect = 5e-05 Identities = 38/143 (26%), Positives = 63/143 (44%), Gaps = 12/143 (8%) Frame = +2 Query: 23 EGNDIGNGGFGKVYRGTLATGQ-----------LVAVKRSQEGSLQGSLEFRTEIELLSR 169 +G +G G +Y GTL + V +K SL F ++ + Sbjct: 584 QGEHLGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQ 643 Query: 170 VHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKS-GVRLDWKRRLRVILGTAKGI 346 V HK++V L G C+ E ++V E++ G L + KS + WK ++ L +A Sbjct: 644 VSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASA--- 700 Query: 347 AYLHELADPPIVHRDIKSSNVLL 415 L L D +VH ++ + N+LL Sbjct: 701 --LSYLEDKDLVHGNVCTKNLLL 721
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 69.7 bits (169), Expect = 3e-12 Identities = 41/131 (31%), Positives = 70/131 (53%), Gaps = 1/131 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G +G G FG+ + T ATG+++ +K + F TE++++ + H NV+ +G Sbjct: 334 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIG 393 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 + L+ EYI GTLK+ L ++ W++++ G A G+AYLH + I+ Sbjct: 394 VLYKDKKLNLLTEYIEGGTLKDFL--RNADPFPWQQKVSFAKGIASGMAYLHSMC---II 448 Query: 383 HRDIKSSNVLL 415 HRD+ S N L+ Sbjct: 449 HRDLNSHNCLI 459
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 69.7 bits (169), Expect = 3e-12 Identities = 52/137 (37%), Positives = 76/137 (55%), Gaps = 8/137 (5%) Frame = +2 Query: 32 DIGNGGFGKV----YRGTL-ATGQLVAVKRSQEG-SLQGSLEFRTEIELLSRVHHKNVVS 193 D+G G FGKV Y T TG++VAVK +EG Q ++ EIE+L ++H+++V Sbjct: 895 DLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVK 954 Query: 194 LVGFCLDQGEQ--MLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELA 367 G C DQGE+ LV EY+P G+L++ L + + L +G+AYLH Sbjct: 955 YKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC---VGLAQLLLFAQQICEGMAYLHA-- 1009 Query: 368 DPPIVHRDIKSSNVLLD 418 +HRD+ + NVLLD Sbjct: 1010 -QHYIHRDLAARNVLLD 1025
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 69.3 bits (168), Expect = 4e-12 Identities = 43/128 (33%), Positives = 76/128 (59%), Gaps = 1/128 (0%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 IG+G F +V++ A+GQ++A+K + S + +L E++L++R+ H N++ +G C+ Sbjct: 64 IGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANL--LKEMQLMNRLSHPNILRFMGVCV 121 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRD 391 QG+ + EYI +G L++ L S + L W R+++ A G++YLH I HRD Sbjct: 122 HQGQLHALTEYINSGNLEQLL--DSNLYLPWTVRVKLAYDIAVGLSYLHFKG---IFHRD 176 Query: 392 IKSSNVLL 415 + S N L+ Sbjct: 177 LTSKNCLI 184
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 68.9 bits (167), Expect = 5e-12 Identities = 43/128 (33%), Positives = 76/128 (59%), Gaps = 1/128 (0%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 IG+G F +V++ A+GQ++A+K + S + +L E++L++R+ H N++ +G C+ Sbjct: 64 IGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANL--LKEMQLMNRLSHPNILRFMGVCV 121 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRD 391 QG+ + EYI +G L++ L S + L W R+++ A G++YLH I HRD Sbjct: 122 HQGQLHALTEYINSGNLEQLL--DSDLYLPWTVRVKLAYDIAVGLSYLHFKG---IFHRD 176 Query: 392 IKSSNVLL 415 + S N L+ Sbjct: 177 LTSKNCLI 184
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 68.9 bits (167), Expect = 5e-12 Identities = 43/136 (31%), Positives = 76/136 (55%), Gaps = 1/136 (0%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNV 187 ++F IG G F +VY+ +GQ++ +K ++ S + + E++L++R+ H N+ Sbjct: 50 DDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNT--LREVQLMNRLRHPNI 107 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELA 367 + +G C+ QG+ + EY+ GTL++ L+ S L W RL + L A+G+ YLH Sbjct: 108 LRFMGVCVHQGQLHALTEYMNGGTLEQLLS--SPEPLSWPVRLHLALDIAQGLRYLHAKG 165 Query: 368 DPPIVHRDIKSSNVLL 415 + HRD+ S N L+ Sbjct: 166 ---VFHRDLTSKNCLV 178
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 68.9 bits (167), Expect = 5e-12 Identities = 43/136 (31%), Positives = 76/136 (55%), Gaps = 1/136 (0%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNV 187 ++F IG G F +VY+ +GQ++ +K ++ S + + E++L++R+ H N+ Sbjct: 50 DDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNT--LREVQLMNRLRHPNI 107 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELA 367 + +G C+ QG+ + EY+ GTL++ L+ S L W RL + L A+G+ YLH Sbjct: 108 LRFMGVCVHQGQLHALTEYMNGGTLEQLLS--SPEPLSWPVRLHLALDIAQGLRYLHAKG 165 Query: 368 DPPIVHRDIKSSNVLL 415 + HRD+ S N L+ Sbjct: 166 ---VFHRDLTSKNCLV 178
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 68.6 bits (166), Expect = 7e-12 Identities = 46/140 (32%), Positives = 68/140 (48%), Gaps = 1/140 (0%) Frame = +2 Query: 20 SEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQG-SLEFRTEIELLSRVHHKNVVSL 196 S G +G G FG+VY+GTL VAVK +E Q ++F E ++L + H N+V L Sbjct: 65 SLGELLGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKL 124 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 +G C + ++ E +P G S K L K+ +R L A G+ YL Sbjct: 125 IGVCTQRQPVYIIMELVPGGDFL-SFLRKRKDELKLKQLVRFSLDVAAGMLYLE---GKN 180 Query: 377 IVHRDIKSSNVLLDERLNAK 436 +HRD+ + N L+ E K Sbjct: 181 CIHRDLAARNCLVGENNTLK 200
>KGS9_YEAST (P43637) Probable serine/threonine-protein kinase YGL179C (EC| 2.7.11.1) Length = 560 Score = 68.2 bits (165), Expect = 9e-12 Identities = 56/163 (34%), Positives = 77/163 (47%), Gaps = 18/163 (11%) Frame = +2 Query: 2 KITNNFSEGNDIGNGGFGKVYRGT-LATGQLVAVK------RSQEGSLQGSLE---FRTE 151 +I NNF +GNG +GKV L TG LVA+K + SLQ +E E Sbjct: 45 QILNNFEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQE 104 Query: 152 IELLSRVHHKNVVSLVGFCLD--QGEQMLVYEYIPNGTLKESLTGKSGVR------LDWK 307 IE++ R HH+NVV L D + LV EY G +K K ++ L ++ Sbjct: 105 IEVMKRCHHENVVELYEILNDPESTKVYLVLEYCSRGPVKWCPENKMEIKAVGPSILTFQ 164 Query: 308 RRLRVILGTAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 + +V+L G+ YLH I HRDIK SN+L+ K Sbjct: 165 QSRKVVLDVVSGLEYLHSQG---ITHRDIKPSNLLISSNGTVK 204
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 68.2 bits (165), Expect = 9e-12 Identities = 42/130 (32%), Positives = 66/130 (50%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G+G +G V + +LVAVK + Q +E E++ LSRV H N+++L G Sbjct: 25 VGHGSYGVVCKAVWRD-KLVAVKEFFASAEQKDIE--KEVKQLSRVKHPNIIALHGISSY 81 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 Q L+ E+ G+L L GK + A+G+AYLH + P++HRD+ Sbjct: 82 QQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDV 141 Query: 395 KSSNVLLDER 424 K N+LL + Sbjct: 142 KPLNLLLTNK 151
>WIS4_SCHPO (O14299) MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase| kinase kinase wak1) (MAP kinase kinase kinase wik1) Length = 1401 Score = 68.2 bits (165), Expect = 9e-12 Identities = 51/149 (34%), Positives = 83/149 (55%), Gaps = 9/149 (6%) Frame = +2 Query: 5 ITNNFSEGNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRT-------EIEL 160 IT + +G+ + +G FG VY G + TG L+AVK E LQ S FR+ E+ + Sbjct: 1033 ITIRWQQGHFVRSGMFGDVYTGVNMETGDLLAVK---EIKLQDSRTFRSTVDQIHNEMTV 1089 Query: 161 LSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRV-ILGTA 337 L R++H NVV+ G + + + + E+ G+L + L R++ + L+V ++ Sbjct: 1090 LERLNHPNVVTYYGVEVHREKVYIFMEFCQGGSLADLLAHG---RIEDENVLKVYVVQLL 1146 Query: 338 KGIAYLHELADPPIVHRDIKSSNVLLDER 424 +G+AY+H I+HRDIK +N+LLD R Sbjct: 1147 EGLAYIHS---QHILHRDIKPANILLDHR 1172
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 68.2 bits (165), Expect = 9e-12 Identities = 43/145 (29%), Positives = 73/145 (50%), Gaps = 2/145 (1%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLE--FRTEIELLSRVHHK 181 +++ E D+ +GGFGKV + V +K+ G + E +++ R+ H Sbjct: 14 SSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMMHRLRHS 73 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 VV L+G +++G LV EY+ G L L + V L K R +I+ +G+ YLH Sbjct: 74 RVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGR--IIVEAIEGMCYLH- 130 Query: 362 LADPPIVHRDIKSSNVLLDERLNAK 436 D ++H+D+K N+L+D + K Sbjct: 131 --DKGVIHKDLKPENILVDRDFHIK 153
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 67.8 bits (164), Expect = 1e-11 Identities = 37/126 (29%), Positives = 63/126 (50%) Frame = +2 Query: 38 GNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLDQ 217 G G FG VYR + + +E +++ L+ E E+LS + H+N++ G L+ Sbjct: 23 GGGSFGSVYRAKW-------ISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEP 75 Query: 218 GEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDIK 397 +V EY G+L + + +D + + AKG+ YLH A ++HRD+K Sbjct: 76 PNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLK 135 Query: 398 SSNVLL 415 S NV++ Sbjct: 136 SRNVVI 141
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 67.4 bits (163), Expect = 1e-11 Identities = 42/139 (30%), Positives = 70/139 (50%), Gaps = 4/139 (2%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGTLATGQ-LVAVKRSQEGSLQGS---LEFRTEIELLSRVHH 178 N+F G +G G FG+VY L +VA+K + ++ + R E+E+ + + H Sbjct: 14 NDFEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQH 73 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLH 358 +N++ L + D L+ EY P G L + L + +LD +R +I + + Y H Sbjct: 74 RNILRLYNYFYDDTRIYLILEYAPGGELYKEL--QRHQKLDQQRTATIIQELSDALTYCH 131 Query: 359 ELADPPIVHRDIKSSNVLL 415 E ++HRDIK N+LL Sbjct: 132 E---KKVIHRDIKPENLLL 147
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 67.4 bits (163), Expect = 1e-11 Identities = 47/142 (33%), Positives = 71/142 (50%), Gaps = 8/142 (5%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGS-LQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 +G GG G Y + VA+K + GS + EF TE ++ + H NV+ L+G Sbjct: 728 MGRGGGGGGYESE--PYETVAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVT 785 Query: 212 DQGEQMLVYEYIPNGTLKESL--TGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVH 385 M+V EY+ NG+L + L T + G ++ W++ ++ G A G+ Y L D VH Sbjct: 786 SAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKY---LTDMGYVH 842 Query: 386 -----RDIKSSNVLLDERLNAK 436 RD+ + NVLLD L K Sbjct: 843 RVSFLRDLAARNVLLDMELRCK 864
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 67.0 bits (162), Expect = 2e-11 Identities = 44/141 (31%), Positives = 70/141 (49%), Gaps = 7/141 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLA-----TGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLV 199 +G G FG V TG++VAVK+ Q + + +F EIE+L + H N+V Sbjct: 855 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 914 Query: 200 GFCLDQGEQ--MLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADP 373 G C G + L+ EY+P G+L++ L K R+D + L+ KG+ Y L Sbjct: 915 GVCYSAGRRNLKLIMEYLPYGSLRDYLQ-KHKERIDHIKLLQYTSQICKGMEY---LGTK 970 Query: 374 PIVHRDIKSSNVLLDERLNAK 436 +HRD+ + N+L++ K Sbjct: 971 RYIHRDLATRNILVENENRVK 991 Score = 48.1 bits (113), Expect = 9e-06 Identities = 38/137 (27%), Positives = 68/137 (49%), Gaps = 10/137 (7%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT----GQL----VAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVV 190 +G G F K+++G GQL V +K + S F ++S++ HK++V Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLV 610 Query: 191 SLVGFCLDQGEQMLVYEYIPNGTLKESL-TGKSGVRLDWKRRLRVILGTAKGIAY-LHEL 364 G C+ E +LV E++ G+L L K+ + + WK L AK +A+ +H L Sbjct: 611 LNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWK------LEVAKQLAWAMHFL 664 Query: 365 ADPPIVHRDIKSSNVLL 415 + ++H ++ + N+LL Sbjct: 665 EENTLIHGNVCAKNILL 681
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 67.0 bits (162), Expect = 2e-11 Identities = 49/137 (35%), Positives = 76/137 (55%), Gaps = 8/137 (5%) Frame = +2 Query: 32 DIGNGGFGKV----YRGTL-ATGQLVAVKRSQ-EGSLQGSLEFRTEIELLSRVHHKNVVS 193 D+G G FGKV Y T TG++VAVK + + Q ++ EI++L ++H++++ Sbjct: 902 DLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIK 961 Query: 194 LVGFCLDQGEQ--MLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELA 367 G C DQGE+ LV EY+P G+L++ L S + + L +G+AYLH Sbjct: 962 YKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS---IGLAQLLLFAQQICEGMAYLHA-- 1016 Query: 368 DPPIVHRDIKSSNVLLD 418 +HRD+ + NVLLD Sbjct: 1017 -QHYIHRDLAARNVLLD 1032 Score = 38.9 bits (89), Expect = 0.006 Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 1/96 (1%) Frame = +2 Query: 131 SLEFRTEIELLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSG-VRLDWK 307 +L F L+S+V H ++ + G C+ E ++V EY+ +G L L + G V + WK Sbjct: 652 ALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWK 711 Query: 308 RRLRVILGTAKGIAYLHELADPPIVHRDIKSSNVLL 415 + L +A L L + +VH ++ N+LL Sbjct: 712 MVVAQQLASA-----LSYLENKNLVHGNVCGRNILL 742
>CC2H3_TRYBB (P54666) Cell division control protein 2 homolog 3 (EC 2.7.11.22)| Length = 311 Score = 67.0 bits (162), Expect = 2e-11 Identities = 44/133 (33%), Positives = 75/133 (56%), Gaps = 6/133 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVK-----RSQEGSLQGSLEFRTEIELLSRVHHKNVVSL 196 +G G +G VYR ATGQ+VA+K R+ EG Q +L E+ +L +HH N+V+L Sbjct: 29 LGEGTYGVVYRAVDRATGQIVALKKVRLDRTDEGIPQTALR---EVSILQEIHHPNIVNL 85 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 + G+ L++EY+ + LK++L + G + ++I +G+++ H Sbjct: 86 LDVICADGKLYLIFEYVDH-DLKKALEKRGGAFTGTTLK-KIIYQLLEGLSFCHR---HR 140 Query: 377 IVHRDIKSSNVLL 415 IVHRD+K +N+L+ Sbjct: 141 IVHRDLKPANILV 153
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 67.0 bits (162), Expect = 2e-11 Identities = 37/126 (29%), Positives = 62/126 (49%) Frame = +2 Query: 38 GNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLDQ 217 G G FG VYR + + +E +++ L+ E E+LS + H+N++ G L+ Sbjct: 23 GGGSFGSVYRAKW-------ISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEP 75 Query: 218 GEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDIK 397 +V EY G+L + + +D + AKG+ YLH A ++HRD+K Sbjct: 76 PNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLK 135 Query: 398 SSNVLL 415 S NV++ Sbjct: 136 SRNVVI 141
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 66.6 bits (161), Expect = 3e-11 Identities = 47/146 (32%), Positives = 70/146 (47%), Gaps = 4/146 (2%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGTLATGQ-LVAVK---RSQEGSLQGSLEFRTEIELLSRVHH 178 ++F G +G G FG VY L +VA+K +SQ + R EIE+ + + H Sbjct: 41 DDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQH 100 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLH 358 N++ L + D L+ EY P G L + L + +LD +R +I A + Y H Sbjct: 101 PNILRLYNYFHDARRVYLILEYAPRGELYKEL--QKSEKLDEQRTATIIEELADALTYCH 158 Query: 359 ELADPPIVHRDIKSSNVLLDERLNAK 436 D ++HRDIK N+LL R K Sbjct: 159 ---DKKVIHRDIKPENLLLGFRGEVK 181
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 65.9 bits (159), Expect = 4e-11 Identities = 42/128 (32%), Positives = 64/128 (50%), Gaps = 1/128 (0%) Frame = +2 Query: 35 IGNGGFGKVYRG-TLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 IG G +G VY+ T Q+VA+K + + + EI LL ++H N+V GF Sbjct: 31 IGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIR 90 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRD 391 E ++ EY NG+L+ L +S L + T G+ YLH ++HRD Sbjct: 91 KSYELYILLEYCANGSLRR-LISRSSTGLSENESKTYVTQTLLGLKYLH---GEGVIHRD 146 Query: 392 IKSSNVLL 415 IK++N+LL Sbjct: 147 IKAANILL 154
>RIPK3_MOUSE (Q9QZL0) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) Length = 486 Score = 65.9 bits (159), Expect = 4e-11 Identities = 48/140 (34%), Positives = 72/140 (51%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT-GQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 +G GGFG V+R T VAVK + S + E++ + + ++NV+ L+G Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVK------IVNSKKISWEVKAMVNLRNENVLLLLGVTE 81 Query: 212 DQ-----GEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 D Q LV ++ NG+L L + W R++ G+ YLH L DPP Sbjct: 82 DLQWDFVSGQALVTRFMENGSLAGLLQPECP--RPWPLLCRLLQEVVLGMCYLHSL-DPP 138 Query: 377 IVHRDIKSSNVLLDERLNAK 436 ++HRD+K SN+LLD L+AK Sbjct: 139 LLHRDLKPSNILLDPELHAK 158
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 65.9 bits (159), Expect = 4e-11 Identities = 33/97 (34%), Positives = 56/97 (57%), Gaps = 1/97 (1%) Frame = +2 Query: 149 EIELLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGV-RLDWKRRLRVI 325 E E+L + ++ ++G C + +V EY+PNG+L E L K+ + W R R++ Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRIL 125 Query: 326 LGTAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ YLH + +PP++H D+K+ N+LLD + K Sbjct: 126 HEIALGVNYLHNM-NPPLLHHDLKTQNILLDNEFHVK 161
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 65.5 bits (158), Expect = 6e-11 Identities = 40/134 (29%), Positives = 73/134 (54%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ G VAVK ++GS+ F E L+ ++ HK +V L + Sbjct: 250 LGAGQFGEVWMGYYNEHTKVAVKSLKQGSMSPDA-FLAEANLMKQLQHKRLVRLYAVVTE 308 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + ++ EY+ NG+L + L SG++L + L + +G+A+L E +HRD+ Sbjct: 309 E-PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIVEGMAFLEE---RNYIHRDL 364 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ + L+ K Sbjct: 365 RAANILVSDTLSCK 378
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 65.5 bits (158), Expect = 6e-11 Identities = 49/151 (32%), Positives = 79/151 (52%), Gaps = 14/151 (9%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRG-TLATGQLVAVKR--------SQEGSLQGSLEFRTEIELLS 166 ++ +G IG G FG VY G L +G+L+AVK+ S+E + E E++LL Sbjct: 68 SWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLK 127 Query: 167 RVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSG-----VRLDWKRRLRVILG 331 + H N+V +G + ++ E++P G++ SL K G V + R+L + Sbjct: 128 NLSHPNIVRYLGTVREDDTLNILLEFVPGGSI-SSLLEKFGPFPESVVRTYTRQLLL--- 183 Query: 332 TAKGIAYLHELADPPIVHRDIKSSNVLLDER 424 G+ YLH A I+HRDIK +N+L+D + Sbjct: 184 ---GLEYLHNHA---IMHRDIKGANILVDNK 208
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 65.5 bits (158), Expect = 6e-11 Identities = 47/139 (33%), Positives = 71/139 (51%), Gaps = 9/139 (6%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT-GQLVAVKRSQEGSLQGSLEFRT--------EIELLSRVHHKNV 187 IG+G FG+VY G A+ G+L+AVK+ S+ S + EI LL + H+++ Sbjct: 400 IGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHI 459 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELA 367 V +G L+ + EY+P G++ LT + I T KG+ YLH Sbjct: 460 VQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLVKNF--IKQTLKGLEYLHSRG 517 Query: 368 DPPIVHRDIKSSNVLLDER 424 IVHRDIK +N+L+D + Sbjct: 518 ---IVHRDIKGANILVDNK 533
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 65.1 bits (157), Expect = 7e-11 Identities = 40/134 (29%), Positives = 74/134 (55%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ G VAVK ++GS+ F E L+ ++ H +V L + Sbjct: 250 LGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDA-FLAEANLMKQLQHPRLVRLYAV-VT 307 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 Q ++ EY+ NG+L + L SG++L+ + L + A+G+A++ E +HRD+ Sbjct: 308 QEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEE---QNYIHRDL 364 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ + L+ K Sbjct: 365 RAANILVSDTLSCK 378
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 65.1 bits (157), Expect = 7e-11 Identities = 40/134 (29%), Positives = 74/134 (55%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ G VAVK ++GS+ F E L+ ++ H+ +V L + Sbjct: 250 LGAGQFGEVWMGYYNDHTKVAVKSLKQGSMSPDA-FLAEANLMKQLQHQRLVRLYAV-VT 307 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 Q ++ EY+ NG+L + L SG++L + L + A+G+A++ E +HRD+ Sbjct: 308 QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEE---RNYIHRDL 364 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ + L+ K Sbjct: 365 RAANILVSDTLSCK 378
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 65.1 bits (157), Expect = 7e-11 Identities = 47/129 (36%), Positives = 69/129 (53%), Gaps = 2/129 (1%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQ--EGSLQGSLEFRTEIELLSRVHHKNVVSLVGFC 208 +G G G V + T Q +AVK E +++ + E EI LS + H+NV+ ++G Sbjct: 17 LGAGSGGAVRKATFQN-QEIAVKIFDFLEETIKKNAE--REITHLSEIDHENVIRVIGRA 73 Query: 209 LDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHR 388 + + L+ EY+ G+L L G ++ +R L AK +AYLH L D PIVHR Sbjct: 74 SNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSL-DRPIVHR 132 Query: 389 DIKSSNVLL 415 DIK N+LL Sbjct: 133 DIKPQNMLL 141
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 65.1 bits (157), Expect = 7e-11 Identities = 42/133 (31%), Positives = 65/133 (48%), Gaps = 1/133 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQG-SLEFRTEIELLSRVHHKNVVSLVG 202 G +G G FG+VY+GTL VAVK +E Q ++F E ++L + H N+V L+G Sbjct: 566 GELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIG 625 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 C + ++ E + G L K L K+ ++ L A G+ YL + Sbjct: 626 VCTQRQPVYIIMELVSGGDFLTFLRRKKD-ELKLKQLVKFSLDAAAGMLYLE---SKNCI 681 Query: 383 HRDIKSSNVLLDE 421 HRD+ + N L+ E Sbjct: 682 HRDLAARNCLVGE 694
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 65.1 bits (157), Expect = 7e-11 Identities = 51/141 (36%), Positives = 70/141 (49%), Gaps = 4/141 (2%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTLA-TGQLVAVK---RSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 G+ +G G FGKV G TG VAVK R + SL + R EI+ L H +++ Sbjct: 21 GDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIK 80 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADP 373 L + +V EY+ G L + + K+G RLD K R+ G+ Y H Sbjct: 81 LYQVISTPSDIFMVMEYVSGGELFDYIC-KNG-RLDEKESRRLFQQILSGVDYCHRHM-- 136 Query: 374 PIVHRDIKSSNVLLDERLNAK 436 +VHRD+K NVLLD +NAK Sbjct: 137 -VVHRDLKPENVLLDAHMNAK 156
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 65.1 bits (157), Expect = 7e-11 Identities = 51/141 (36%), Positives = 70/141 (49%), Gaps = 4/141 (2%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTLA-TGQLVAVK---RSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 G+ +G G FGKV G TG VAVK R + SL + R EI+ L H +++ Sbjct: 21 GDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIK 80 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADP 373 L + +V EY+ G L + + K+G RLD K R+ G+ Y H Sbjct: 81 LYQVISTPSDIFMVMEYVSGGELFDYIC-KNG-RLDEKESRRLFQQILSGVDYCHRHM-- 136 Query: 374 PIVHRDIKSSNVLLDERLNAK 436 +VHRD+K NVLLD +NAK Sbjct: 137 -VVHRDLKPENVLLDAHMNAK 156
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 65.1 bits (157), Expect = 7e-11 Identities = 46/137 (33%), Positives = 69/137 (50%), Gaps = 4/137 (2%) Frame = +2 Query: 17 FSEGNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSL-QGSLE--FRTEIELLSRVHHKN 184 F G +G G FG+VY TG +VA+K + L Q +E R EIE+ S + HKN Sbjct: 89 FEIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKN 148 Query: 185 VVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHEL 364 ++ L G D+ L+ E+ G L + L + R + + I A ++YLH+ Sbjct: 149 ILRLYGHFHDEKRIYLILEFAGRGELYQHL--RRAKRFSEEVASKYIFQMANALSYLHK- 205 Query: 365 ADPPIVHRDIKSSNVLL 415 ++HRDIK N+LL Sbjct: 206 --KHVIHRDIKPENILL 220
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 65.1 bits (157), Expect = 7e-11 Identities = 33/97 (34%), Positives = 55/97 (56%), Gaps = 1/97 (1%) Frame = +2 Query: 149 EIELLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGV-RLDWKRRLRVI 325 E E+L + ++ ++G C + +V EY+PNG+L E L K+ + W R R++ Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRIL 125 Query: 326 LGTAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ YLH + PP++H D+K+ N+LLD + K Sbjct: 126 HEIALGVNYLHNMT-PPLLHHDLKTQNILLDNEFHVK 161
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 65.1 bits (157), Expect = 7e-11 Identities = 51/141 (36%), Positives = 70/141 (49%), Gaps = 4/141 (2%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTLA-TGQLVAVK---RSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 G+ +G G FGKV G TG VAVK R + SL + R EI+ L H +++ Sbjct: 19 GDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIK 78 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADP 373 L + +V EY+ G L + + K+G RLD K R+ G+ Y H Sbjct: 79 LYQVISTPSDIFMVMEYVSGGELFDYIC-KNG-RLDEKESRRLFQQILSGVDYCHRHM-- 134 Query: 374 PIVHRDIKSSNVLLDERLNAK 436 +VHRD+K NVLLD +NAK Sbjct: 135 -VVHRDLKPENVLLDAHMNAK 154
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 65.1 bits (157), Expect = 7e-11 Identities = 51/141 (36%), Positives = 70/141 (49%), Gaps = 4/141 (2%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTLA-TGQLVAVK---RSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 G+ +G G FGKV G TG VAVK R + SL + R EI+ L H +++ Sbjct: 19 GDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIK 78 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADP 373 L + +V EY+ G L + + K+G RLD K R+ G+ Y H Sbjct: 79 LYQVISTPSDIFMVMEYVSGGELFDYIC-KNG-RLDEKESRRLFQQILSGVDYCHRHM-- 134 Query: 374 PIVHRDIKSSNVLLDERLNAK 436 +VHRD+K NVLLD +NAK Sbjct: 135 -VVHRDLKPENVLLDAHMNAK 154
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 64.7 bits (156), Expect = 1e-10 Identities = 40/134 (29%), Positives = 74/134 (55%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ G VAVK ++GS+ F E L+ ++ H+ +V L + Sbjct: 250 LGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDA-FLAEANLMKQLQHQRLVRLYAV-VT 307 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 Q ++ EY+ NG+L + L SG++L + L + A+G+A++ E +HRD+ Sbjct: 308 QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEE---RNYIHRDL 364 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ + L+ K Sbjct: 365 RAANILVSDTLSCK 378
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 64.7 bits (156), Expect = 1e-10 Identities = 46/152 (30%), Positives = 71/152 (46%), Gaps = 17/152 (11%) Frame = +2 Query: 32 DIGNGGFGKVYRG---TLATGQ---LVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G G FGKV+ L Q LVAVK ++ S +F E ELL+ + H+++V Sbjct: 539 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 598 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESL-----------TGKSGVRLDWKRRLRVILGTAK 340 G C++ ++V+EY+ +G L + L G L + L + A Sbjct: 599 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQIAA 658 Query: 341 GIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 G+ Y LA VHRD+ + N L+ E L K Sbjct: 659 GMVY---LASQHFVHRDLATRNCLVGENLLVK 687
>M3K3_MOUSE (Q61084) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 64.7 bits (156), Expect = 1e-10 Identities = 52/150 (34%), Positives = 78/150 (52%), Gaps = 9/150 (6%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRG-TLATGQLVAVKRSQ--EGSLQGSLE---FRTEIELLSRVH 175 N+ G +G G FG+VY + TG+ +A K+ Q S + S E EI+LL + Sbjct: 361 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ 420 Query: 176 HKNVVSLVGFCLDQGEQMLVY--EYIPNGTLKESLTGKSGVRLDWKRRL-RVILGTAKGI 346 H+ +V G D+ E++L EY+P G++K+ L + R+ R IL +G+ Sbjct: 421 HERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQIL---EGM 477 Query: 347 AYLHELADPPIVHRDIKSSNVLLDERLNAK 436 +YLH IVHRDIK +N+L D N K Sbjct: 478 SYLHSNM---IVHRDIKGANILRDSAGNVK 504
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 64.7 bits (156), Expect = 1e-10 Identities = 46/152 (30%), Positives = 71/152 (46%), Gaps = 17/152 (11%) Frame = +2 Query: 32 DIGNGGFGKVYRG---TLATGQ---LVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G G FGKV+ L Q LVAVK ++ S +F E ELL+ + H+++V Sbjct: 542 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 601 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESL-----------TGKSGVRLDWKRRLRVILGTAK 340 G C++ ++V+EY+ +G L + L G L + L + A Sbjct: 602 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAA 661 Query: 341 GIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 G+ Y LA VHRD+ + N L+ E L K Sbjct: 662 GMVY---LASQHFVHRDLATRNCLVGENLLVK 690
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 64.7 bits (156), Expect = 1e-10 Identities = 46/152 (30%), Positives = 71/152 (46%), Gaps = 17/152 (11%) Frame = +2 Query: 32 DIGNGGFGKVYRG---TLATGQ---LVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G G FGKV+ L Q LVAVK ++ S +F E ELL+ + H+++V Sbjct: 542 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 601 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESL-----------TGKSGVRLDWKRRLRVILGTAK 340 G C++ ++V+EY+ +G L + L G L + L + A Sbjct: 602 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAA 661 Query: 341 GIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 G+ Y LA VHRD+ + N L+ E L K Sbjct: 662 GMVY---LASQHFVHRDLATRNCLVGENLLVK 690
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 64.7 bits (156), Expect = 1e-10 Identities = 46/152 (30%), Positives = 71/152 (46%), Gaps = 17/152 (11%) Frame = +2 Query: 32 DIGNGGFGKVYRG---TLATGQ---LVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G G FGKV+ L Q LVAVK ++ S +F E ELL+ + H+++V Sbjct: 543 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 602 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESL-----------TGKSGVRLDWKRRLRVILGTAK 340 G C++ ++V+EY+ +G L + L G L + L + A Sbjct: 603 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAA 662 Query: 341 GIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 G+ Y LA VHRD+ + N L+ E L K Sbjct: 663 GMVY---LASQHFVHRDLATRNCLVGENLLVK 691
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 64.3 bits (155), Expect = 1e-10 Identities = 42/140 (30%), Positives = 71/140 (50%), Gaps = 3/140 (2%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRT--EIELLSRVHHKN 184 ++++ IG G +G VY+G TGQ+VA+K+ + S + + EI LL +HH N Sbjct: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELHHPN 62 Query: 185 VVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHEL 364 +V L + L++E++ K T SG LD R + +GI + H Sbjct: 63 IVCLQDVLMQDARLYLIFEFLSMDLKKYLDTIPSGQYLDRSRVKSYLYQILQGIVFCHSR 122 Query: 365 ADPPIVHRDIKSSNVLLDER 424 ++HRD+K N+L+D++ Sbjct: 123 R---VLHRDLKPQNLLIDDK 139
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 64.3 bits (155), Expect = 1e-10 Identities = 47/139 (33%), Positives = 72/139 (51%), Gaps = 4/139 (2%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYR-GTLATGQLVAVKRSQEGSL-QGSLE--FRTEIELLSRVHH 178 ++F G +G G FGKVY TG + A+K ++ L +G++E FR E+E+ S + H Sbjct: 97 DDFEIGKALGKGKFGKVYLVKDKKTGFVSALKCMEKKELVEGNVEKQFRREVEIQSNLRH 156 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLH 358 NV+ L G D+ L+ EY+ +G L + L + R I ++ + YLH Sbjct: 157 TNVLRLFGHFHDKDRVYLILEYVVHGELYKLLRNQK--RFTESTASSYIYQMSEALLYLH 214 Query: 359 ELADPPIVHRDIKSSNVLL 415 I+HRDIK N+LL Sbjct: 215 ---GKNIIHRDIKPENILL 230
>ROR1_HUMAN (Q01973) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) Length = 937 Score = 64.3 bits (155), Expect = 1e-10 Identities = 46/156 (29%), Positives = 76/156 (48%), Gaps = 21/156 (13%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLAT-----GQLVAVKRSQE-GSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G FGK+Y+G L QLVA+K ++ + Q +EF+ E L++ +HH N+V Sbjct: 478 ELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWMEFQQEASLMAELHHPNIVC 537 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESL---------------TGKSGVRLDWKRRLRVIL 328 L+G + +++EYI G L E L G LD L + + Sbjct: 538 LLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAI 597 Query: 329 GTAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ Y L+ VH+D+ + N+L+ E+L+ K Sbjct: 598 QIAAGMEY---LSSHFFVHKDLAARNILIGEQLHVK 630
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 63.9 bits (154), Expect = 2e-10 Identities = 43/140 (30%), Positives = 71/140 (50%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQ-----LVAVKRSQEGSLQGS-LEFRTEIELLSRVHHKNVVSL 196 IG G FG+VY+GTL VA+K + G + ++F +E ++ + H N++ L Sbjct: 620 IGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIPL 679 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G M++ EY+ NG L + L K G + + ++ G A G+ Y LA+ Sbjct: 680 EGVVSKYKPMMIITEYMENGALDKFLREKDG-EFSVLQLVGMLRGIASGMKY---LANMN 735 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N+L++ L K Sbjct: 736 YVHRDLAARNILVNSNLVCK 755
>M3K3_HUMAN (Q99759) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 63.9 bits (154), Expect = 2e-10 Identities = 52/150 (34%), Positives = 77/150 (51%), Gaps = 9/150 (6%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRG-TLATGQLVAVKRSQ--EGSLQGSLE---FRTEIELLSRVH 175 N+ G +G G FG+VY + TG+ +A K+ Q S + S E EI+LL + Sbjct: 361 NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ 420 Query: 176 HKNVVSLVGFCLDQGEQMLVY--EYIPNGTLKESLTGKSGVRLDWKRRL-RVILGTAKGI 346 H+ +V G D+ E+ L EY+P G++K+ L + R+ R IL +G+ Sbjct: 421 HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQIL---EGM 477 Query: 347 AYLHELADPPIVHRDIKSSNVLLDERLNAK 436 +YLH IVHRDIK +N+L D N K Sbjct: 478 SYLHSNM---IVHRDIKGANILRDSAGNVK 504
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 63.9 bits (154), Expect = 2e-10 Identities = 46/140 (32%), Positives = 70/140 (50%), Gaps = 3/140 (2%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTL-ATGQLVAVKRSQEGSLQGSLE--FRTEIELLSRVHHKNVVSL 196 G IG G FG+V+ G L A VAVK +E +L L+ F E +L + +H N+V L Sbjct: 615 GERIGRGNFGEVFSGRLRADNTPVAVKSCRE-TLPPELKAKFLQEARILKQCNHPNIVRL 673 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 +G C + +V E + G L K G RL K+ ++++ A G+ YL Sbjct: 674 IGVCTQKQPIYIVMELVQGGDFLSFLRSK-GPRLKMKKLIKMMENAAAGMEYLE---SKH 729 Query: 377 IVHRDIKSSNVLLDERLNAK 436 +HRD+ + N L+ E+ K Sbjct: 730 CIHRDLAARNCLVTEKNTLK 749
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 63.5 bits (153), Expect = 2e-10 Identities = 46/148 (31%), Positives = 80/148 (54%), Gaps = 14/148 (9%) Frame = +2 Query: 23 EGNDIGNGGFGKVYRG-TLATGQLVAVKR-------SQEGSLQGSL-EFRTEIELLSRVH 175 +G IG G FG+VY G L +G+L+A+K+ + + QG + E E++LL + Sbjct: 70 KGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLS 129 Query: 176 HKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSG-----VRLDWKRRLRVILGTAK 340 H N+V +G + ++ E++P G++ SL K G V + + ++L + Sbjct: 130 HPNIVRYLGTVRESDSLNILMEFVPGGSI-SSLLEKFGSFPEPVIIMYTKQLLL------ 182 Query: 341 GIAYLHELADPPIVHRDIKSSNVLLDER 424 G+ YLH + I+HRDIK +N+L+D + Sbjct: 183 GLEYLH---NNGIMHRDIKGANILVDNK 207
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC| 2.7.10.2) (C-FES) Length = 820 Score = 63.2 bits (152), Expect = 3e-10 Identities = 45/136 (33%), Positives = 68/136 (50%), Gaps = 3/136 (2%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTL-ATGQLVAVKRSQEGSLQGSLE--FRTEIELLSRVHHKNVVSL 196 G IG G FG+V+ G L A LVAVK +E +L ++ F E ++L + H N+V L Sbjct: 562 GEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDIKAKFLQEAKILKQYSHPNIVRL 620 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 +G C + +V E + G L G RL K L+++ A G+ YL Sbjct: 621 IGVCTQKQPIYIVMELVQGGDFLTFLR-TEGARLRMKTLLQMVGDAAAGMEYLESKC--- 676 Query: 377 IVHRDIKSSNVLLDER 424 +HRD+ + N L+ E+ Sbjct: 677 CIHRDLAARNCLVTEK 692
>SGG_DROME (P18431) Protein kinase shaggy (EC 2.7.11.1) (Protein zeste-white 3)| Length = 1067 Score = 63.2 bits (152), Expect = 3e-10 Identities = 48/145 (33%), Positives = 75/145 (51%), Gaps = 10/145 (6%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRGTLA-TGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVV 190 ++++ IGNG FG V++ L TG+LVA+K+ LQ E++++ ++ H N+V Sbjct: 606 SYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKV----LQDRRFKNRELQIMRKLEHCNIV 661 Query: 191 SLVGFCLDQGEQM------LVYEYIPNGTLK---ESLTGKSGVRLDWKRRLRVILGTAKG 343 L+ F GE+ LV EYIP K + K + +++ R L + Sbjct: 662 KLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQL--FRS 719 Query: 344 IAYLHELADPPIVHRDIKSSNVLLD 418 +AY+H L I HRDIK N+LLD Sbjct: 720 LAYIHSLG---ICHRDIKPQNLLLD 741
>FES_FSVGA (P00542) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 609 Score = 63.2 bits (152), Expect = 3e-10 Identities = 45/136 (33%), Positives = 68/136 (50%), Gaps = 3/136 (2%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTL-ATGQLVAVKRSQEGSLQGSLE--FRTEIELLSRVHHKNVVSL 196 G IG G FG+V+ G L A LVAVK +E +L ++ F E ++L + H N+V L Sbjct: 351 GEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDIKAKFLQEAKILKQYSHPNIVRL 409 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 +G C + +V E + G L G RL K L+++ A G+ YL Sbjct: 410 IGVCTQKQPIYIVMELVQGGDFLTFLR-TEGARLRMKTLLQMVGDAAAGMEYLESKC--- 465 Query: 377 IVHRDIKSSNVLLDER 424 +HRD+ + N L+ E+ Sbjct: 466 CIHRDLAARNCLVTEK 481
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 63.2 bits (152), Expect = 3e-10 Identities = 45/136 (33%), Positives = 68/136 (50%), Gaps = 3/136 (2%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTL-ATGQLVAVKRSQEGSLQGSLE--FRTEIELLSRVHHKNVVSL 196 G IG G FG+V+ G L A LVAVK +E +L ++ F E ++L + H N+V L Sbjct: 219 GEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDIKAKFLQEAKILKQYSHPNIVRL 277 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 +G C + +V E + G L G RL K L+++ A G+ YL Sbjct: 278 IGVCTQKQPIYIVMELVQGGDFLTFLR-TEGARLRMKTLLQMVGDAAAGMEYLESKC--- 333 Query: 377 IVHRDIKSSNVLLDER 424 +HRD+ + N L+ E+ Sbjct: 334 CIHRDLAARNCLVTEK 349
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 63.2 bits (152), Expect = 3e-10 Identities = 45/139 (32%), Positives = 69/139 (49%), Gaps = 4/139 (2%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGTLATGQ-LVAVK---RSQEGSLQGSLEFRTEIELLSRVHH 178 +NF G +G G FG VY + +VA+K +SQ + R EIE+ + + H Sbjct: 78 DNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKH 137 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLH 358 N++ L + DQ L+ EY P G L + L KSG D +R ++ + + Y H Sbjct: 138 PNILQLYNYFYDQQRIYLILEYAPRGELYKELQ-KSGT-FDEQRTATIMEELSDALMYCH 195 Query: 359 ELADPPIVHRDIKSSNVLL 415 + ++HRDIK N+LL Sbjct: 196 K---KKVIHRDIKPENLLL 211
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 63.2 bits (152), Expect = 3e-10 Identities = 39/134 (29%), Positives = 67/134 (50%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ G VAVK + G++ + F E ++ ++ HK++V L C D Sbjct: 246 LGAGQFGEVWAGVWNNTTQVAVKTLKPGTMSPA-SFLDEAGVMKKLRHKHLVQLYAICSD 304 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L+ GV L + + A G+A+L +HRD+ Sbjct: 305 REPIYIVTEYMSGGSLLDYLSKGEGVNLQLPTLIDMAAQVASGMAFLEAQG---YIHRDL 361 Query: 395 KSSNVLLDERLNAK 436 + N+L+ E K Sbjct: 362 AARNILVGENYICK 375
>DUN1_YEAST (P39009) DNA damage response protein kinase DUN1 (EC 2.7.11.1)| Length = 513 Score = 63.2 bits (152), Expect = 3e-10 Identities = 50/140 (35%), Positives = 73/140 (52%), Gaps = 9/140 (6%) Frame = +2 Query: 26 GNDIGNGGFGKVYRG-TLATGQLVAVK---RSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 G ++G G + V TGQ VAVK Q + + +FR E +L RV H N+V+ Sbjct: 203 GKELGAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQHPNIVN 262 Query: 194 LVGFCLD-----QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLH 358 L+ ++ Q ++ LV E I +G L E + K+ +R D + L L T G+ YLH Sbjct: 263 LLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLT--GLKYLH 320 Query: 359 ELADPPIVHRDIKSSNVLLD 418 E I+HRDIK N+LL+ Sbjct: 321 E---QNIIHRDIKPENILLN 337
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 63.2 bits (152), Expect = 3e-10 Identities = 48/145 (33%), Positives = 68/145 (46%), Gaps = 4/145 (2%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGS---LEFRTEIELLSRVHHK 181 NF IG G FG V RGT + TG VA+K G ++G + R EI+ L ++ H Sbjct: 23 NFVIKETIGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTHP 82 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 ++ L + LV E + G L +T K + + RR G++Y H Sbjct: 83 HITRLFRVISTPSDIFLVMELVSGGELFSYITRKGALPIRESRRY--FQQIISGVSYCH- 139 Query: 362 LADPPIVHRDIKSSNVLLDERLNAK 436 + IVHRD+K N+LLD N K Sbjct: 140 --NHMIVHRDLKPENLLLDANKNIK 162
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 62.8 bits (151), Expect = 4e-10 Identities = 39/134 (29%), Positives = 66/134 (49%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ G VAVK +EG++ + F E ++ + H +V+L C Sbjct: 290 LGRGNFGEVFYGKWRNSIDVAVKTLREGTM-STAAFLQEAAIMKKFRHNRLVALYAVCSQ 348 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G L ++ + + A G+ YL ++HRD+ Sbjct: 349 EEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLE---SKQLIHRDL 405 Query: 395 KSSNVLLDERLNAK 436 + NVL+ E AK Sbjct: 406 AARNVLIGENNVAK 419
>ZYG1_CAEBR (Q621J7) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 709 Score = 62.8 bits (151), Expect = 4e-10 Identities = 38/137 (27%), Positives = 64/137 (46%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVV 190 ++F IG GGFG VY G+ VA+K+ G+ + EI+ + + H+N+V Sbjct: 11 SSFQNLQQIGQGGFGVVYSAQRENGEKVAIKKI--GNAASQTRIKEEIKTMKLLRHRNIV 68 Query: 191 SLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELAD 370 + GE LV E G+L + + K LD + ++ + Y+H D Sbjct: 69 QFYETFFENGETYLVMELCEGGSLMDYVKQKG--PLDDSTAVHILRQLIAAVKYIH---D 123 Query: 371 PPIVHRDIKSSNVLLDE 421 I+HRD+ + NV + + Sbjct: 124 ENILHRDLSAGNVFIKD 140
>FES_HUMAN (P07332) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 822 Score = 62.8 bits (151), Expect = 4e-10 Identities = 46/136 (33%), Positives = 67/136 (49%), Gaps = 3/136 (2%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTL-ATGQLVAVKRSQEGSLQGSLE--FRTEIELLSRVHHKNVVSL 196 G IG G FG+V+ G L A LVAVK +E +L L+ F E +L + H N+V L Sbjct: 564 GEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNIVRL 622 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 +G C + +V E + G L G RL K L+++ A G+ YL Sbjct: 623 IGVCTQKQPIYIVMELVQGGDFLTFLR-TEGARLRVKTLLQMVGDAAAGMEYLESKC--- 678 Query: 377 IVHRDIKSSNVLLDER 424 +HRD+ + N L+ E+ Sbjct: 679 CIHRDLAARNCLVTEK 694
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 62.8 bits (151), Expect = 4e-10 Identities = 45/151 (29%), Positives = 77/151 (50%), Gaps = 24/151 (15%) Frame = +2 Query: 35 IGNGGFGKVYRGTLA------TGQLVAVKRSQEGSLQGSL--EFRTEIELLSRVHHKNVV 190 IG G FG+V+ GT A +VAVK + +GS SL +F E E+L+ + H N+V Sbjct: 510 IGEGAFGRVFLGTCAHLIQKNEFAIVAVK-TLKGSCSDSLKRDFEREAEMLATIEHANIV 568 Query: 191 SLVGFCLDQGEQMLVYEYIPNGTL----------------KESLTGKSGVRLDWKRRLRV 322 + G C + + M+++E++ NG L ++S+ G +L ++ +++ Sbjct: 569 TFYGVCTESDQWMMIFEFMENGDLNKYLRMHGPDAAFLKDRDSMDSDEG-QLTREQLMKI 627 Query: 323 ILGTAKGIAYLHELADPPIVHRDIKSSNVLL 415 +L A + Y LA VHRD+ + N L+ Sbjct: 628 VLQIASAMEY---LALQHFVHRDLATRNCLV 655
>ROS_CHICK (P08941) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2311 Score = 62.8 bits (151), Expect = 4e-10 Identities = 47/143 (32%), Positives = 69/143 (48%), Gaps = 13/143 (9%) Frame = +2 Query: 35 IGNGGFGKVYRGT----LATG---QLVAVKRSQEGSL-QGSLEFRTEIELLSRVHHKNVV 190 +G+G FG+VY GT LA G VAVK + G+ Q EF E L+S+ H +++ Sbjct: 1967 LGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMSKFDHPHIL 2026 Query: 191 SLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVR-----LDWKRRLRVILGTAKGIAYL 355 L+G CL Q L+ E + G L L G + L L + L KG YL Sbjct: 2027 KLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLDICLDICKGCVYL 2086 Query: 356 HELADPPIVHRDIKSSNVLLDER 424 ++ +HRD+ + N L+ E+ Sbjct: 2087 EKMR---FIHRDLAARNCLVSEK 2106
>ROS_AVISU (P00529) Tyrosine-protein kinase transforming protein ros (EC| 2.7.10.1) Length = 402 Score = 62.8 bits (151), Expect = 4e-10 Identities = 47/143 (32%), Positives = 69/143 (48%), Gaps = 13/143 (9%) Frame = +2 Query: 35 IGNGGFGKVYRGT----LATG---QLVAVKRSQEGSL-QGSLEFRTEIELLSRVHHKNVV 190 +G+G FG+VY GT LA G VAVK + G+ Q EF E L+S+ H +++ Sbjct: 104 LGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMSKFDHPHIL 163 Query: 191 SLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVR-----LDWKRRLRVILGTAKGIAYL 355 L+G CL Q L+ E + G L L G + L L + L KG YL Sbjct: 164 KLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLDICLDICKGCVYL 223 Query: 356 HELADPPIVHRDIKSSNVLLDER 424 ++ +HRD+ + N L+ E+ Sbjct: 224 EKMR---FIHRDLAARNCLVSEK 243
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 62.8 bits (151), Expect = 4e-10 Identities = 48/146 (32%), Positives = 77/146 (52%), Gaps = 12/146 (8%) Frame = +2 Query: 23 EGNDIGNGGFGKVYRG-TLATGQLVAVKR--------SQEGSLQGSLEFRTEIELLSRVH 175 +G IG G FG VY G L +G+L+AVK+ S+E + E E++LL + Sbjct: 70 KGQLIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLS 129 Query: 176 HKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRL---RVILGTAKGI 346 H N+V +G + ++ E++P G++ SL K G + R +++L G+ Sbjct: 130 HPNIVRYLGTVREDETLNILLEFVPGGSI-SSLLEKFGAFPESVVRTYTNQLLL----GL 184 Query: 347 AYLHELADPPIVHRDIKSSNVLLDER 424 YLH A I+HRDIK +N+L+D + Sbjct: 185 EYLHNHA---IMHRDIKGANILVDNQ 207
>M3K5_HUMAN (Q99683) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1374 Score = 62.4 bits (150), Expect = 5e-10 Identities = 43/130 (33%), Positives = 64/130 (49%), Gaps = 2/130 (1%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQL-VAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 +G G +G VY G + Q+ +A+K E + S EI L + HKN+V +G Sbjct: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 745 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVIL-GTAKGIAYLHELADPPIVHR 388 + G + E +P G+L L K G D ++ + +G+ YLH D IVHR Sbjct: 746 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLH---DNQIVHR 802 Query: 389 DIKSSNVLLD 418 DIK NVL++ Sbjct: 803 DIKGDNVLIN 812
>M3K2_HUMAN (Q9Y2U5) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 62.4 bits (150), Expect = 5e-10 Identities = 53/150 (35%), Positives = 77/150 (51%), Gaps = 9/150 (6%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRG-TLATGQLVAVKRSQ--EGSLQGSLEFRT---EIELLSRVH 175 N+ G +G G FG+VY + TG+ +AVK+ Q S + S E EI+LL + Sbjct: 355 NWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLL 414 Query: 176 HKNVVSLVGFCLDQGEQML--VYEYIPNGTLKESLTGKSGVRLDWKRRL-RVILGTAKGI 346 H+ +V G D E+ L EY+P G++K+ L + + R+ R IL +G+ Sbjct: 415 HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQIL---EGV 471 Query: 347 AYLHELADPPIVHRDIKSSNVLLDERLNAK 436 YLH IVHRDIK +N+L D N K Sbjct: 472 HYLHSNM---IVHRDIKGANILRDSTGNVK 498
>M3K5_MOUSE (O35099) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1380 Score = 62.4 bits (150), Expect = 5e-10 Identities = 43/130 (33%), Positives = 64/130 (49%), Gaps = 2/130 (1%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQL-VAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 +G G +G VY G + Q+ +A+K E + S EI L + HKN+V +G Sbjct: 693 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 752 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVIL-GTAKGIAYLHELADPPIVHR 388 + G + E +P G+L L K G D ++ + +G+ YLH D IVHR Sbjct: 753 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLH---DNQIVHR 809 Query: 389 DIKSSNVLLD 418 DIK NVL++ Sbjct: 810 DIKGDNVLIN 819
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 62.4 bits (150), Expect = 5e-10 Identities = 48/142 (33%), Positives = 73/142 (51%), Gaps = 9/142 (6%) Frame = +2 Query: 23 EGNDIGNGGFGKVYRG-TLATGQLVAVKR-------SQEGSLQGSLE-FRTEIELLSRVH 175 +G IG G FG VY + TG+++AVK+ SQ ++ ++E R+E+ L + Sbjct: 1177 KGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLD 1236 Query: 176 HKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYL 355 H N+V +GF L EY+ G++ SL G R D + KG+AYL Sbjct: 1237 HLNIVQYLGFENKNNIYSLFLEYVAGGSV-GSLIRMYG-RFDEPLIKHLTTQVLKGLAYL 1294 Query: 356 HELADPPIVHRDIKSSNVLLDE 421 H I+HRD+K+ N+LLD+ Sbjct: 1295 HSKG---ILHRDMKADNLLLDQ 1313
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 62.4 bits (150), Expect = 5e-10 Identities = 40/134 (29%), Positives = 68/134 (50%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 IG G FG V+RG V V + + + + + F+ E+++L + H N++ +GF Sbjct: 316 IGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 375 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 G ++ ++ +L L + R D + + V TA+G+ YLH I+HRD+ Sbjct: 376 PG-FAIITQWCEGSSLYHHL-HVADTRFDMVQLIDVARQTAQGMDYLHA---KNIIHRDL 430 Query: 395 KSSNVLLDERLNAK 436 KS+N+ L E L K Sbjct: 431 KSNNIFLHEGLTVK 444
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 62.4 bits (150), Expect = 5e-10 Identities = 38/138 (27%), Positives = 74/138 (53%), Gaps = 4/138 (2%) Frame = +2 Query: 35 IGNGGFGKVYRGTLA-TGQLVAVKRSQEGSLQGSLEF---RTEIELLSRVHHKNVVSLVG 202 +G G +GKV R T +G++VA+K ++ ++ L+ R EIE++S ++H +++S+ Sbjct: 62 LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYE 121 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 ++ + +++ EY G L + ++ + RL + + Y H+ +V Sbjct: 122 VFENKDKIVIIMEYASKGELYDYISERR--RLSERETRHFFRQIVSAVHYCHKNG---VV 176 Query: 383 HRDIKSSNVLLDERLNAK 436 HRD+K N+LLD+ N K Sbjct: 177 HRDLKLENILLDDNCNIK 194
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 62.0 bits (149), Expect = 6e-10 Identities = 40/134 (29%), Positives = 68/134 (50%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 IG G FG V+RG V V + + + + + F+ E+++L + H N++ +GF Sbjct: 314 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 373 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 G ++ ++ +L L + R D + + V TA+G+ YLH I+HRD+ Sbjct: 374 PG-FAIITQWCEGSSLYHHL-HVADTRFDMVQLIDVARQTAQGMDYLHA---KNIIHRDL 428 Query: 395 KSSNVLLDERLNAK 436 KS+N+ L E L K Sbjct: 429 KSNNIFLHEGLTVK 442
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 62.0 bits (149), Expect = 6e-10 Identities = 40/134 (29%), Positives = 68/134 (50%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 IG G FG V+RG V V + + + + + F+ E+++L + H N++ +GF Sbjct: 314 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 373 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 G ++ ++ +L L + R D + + V TA+G+ YLH I+HRD+ Sbjct: 374 PG-FAIITQWCEGSSLYHHL-HVADTRFDMVQLIDVARQTAQGMDYLHA---KNIIHRDL 428 Query: 395 KSSNVLLDERLNAK 436 KS+N+ L E L K Sbjct: 429 KSNNIFLHEGLTVK 442
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 62.0 bits (149), Expect = 6e-10 Identities = 40/134 (29%), Positives = 68/134 (50%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 IG G FG V+RG V V + + + + + F+ E+++L + H N++ +GF Sbjct: 316 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 375 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 G ++ ++ +L L + R D + + V TA+G+ YLH I+HRD+ Sbjct: 376 PG-FAIITQWCEGSSLYHHL-HVADTRFDMVQLIDVARQTAQGMDYLHA---KNIIHRDL 430 Query: 395 KSSNVLLDERLNAK 436 KS+N+ L E L K Sbjct: 431 KSNNIFLHEGLTVK 444
>7LESS_DROME (P13368) Protein sevenless (EC 2.7.10.1)| Length = 2554 Score = 62.0 bits (149), Expect = 6e-10 Identities = 45/143 (31%), Positives = 66/143 (46%), Gaps = 14/143 (9%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATG-----QLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLV 199 +G+G FG+VY G L T Q VA+K ++G+ + + E E +L+S H+N+V LV Sbjct: 2215 LGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFA-ELLQEAQLMSNFKHENIVCLV 2273 Query: 200 GFCLDQGEQMLVYEYIPNGTLKESLTGKSGVR---------LDWKRRLRVILGTAKGIAY 352 G C D L+ E++ G L L L L + + A G +Y Sbjct: 2274 GICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSY 2333 Query: 353 LHELADPPIVHRDIKSSNVLLDE 421 L D VHRD+ N L+ E Sbjct: 2334 LE---DMHFVHRDLACRNCLVTE 2353
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 62.0 bits (149), Expect = 6e-10 Identities = 43/143 (30%), Positives = 75/143 (52%), Gaps = 3/143 (2%) Frame = +2 Query: 17 FSEGNDIGNGGFGKVYRGTLATGQL-VAVKRSQEGSLQGS--LEFRTEIELLSRVHHKNV 187 F+ +G+GGFG+VY+ + +A+K S + +E E + + + + Sbjct: 22 FTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYI 81 Query: 188 VSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELA 367 + + G C + LV EY+ G+L++ L + L W R R+I TA G+ +LH +A Sbjct: 82 LPVYGICREPVG--LVMEYMETGSLEKLLASEP---LPWDLRFRIIHETAVGMNFLHCMA 136 Query: 368 DPPIVHRDIKSSNVLLDERLNAK 436 PP++H D+K +N+LLD + K Sbjct: 137 -PPLLHLDLKPANILLDAHYHVK 158
>M3K4_MOUSE (O08648) Mitogen-activated protein kinase kinase kinase 4 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) Length = 1597 Score = 61.6 bits (148), Expect = 8e-10 Identities = 46/141 (32%), Positives = 72/141 (51%), Gaps = 3/141 (2%) Frame = +2 Query: 2 KITNNFSEGNDIGNGGFGKVYRG-TLATGQLVAVK--RSQEGSLQGSLEFRTEIELLSRV 172 K+T + GN IG G +GKVY ++ TG+L+A+K R Q + E E+++ + Sbjct: 1327 KVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI 1386 Query: 173 HHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAY 352 H N+V G L + E + EY GTL+E RL + + + L T + Sbjct: 1387 KHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV------SRLGLQEHV-IRLYTKQITVA 1439 Query: 353 LHELADPPIVHRDIKSSNVLL 415 ++ L + IVHRDIK +N+ L Sbjct: 1440 INVLHEHGIVHRDIKGANIFL 1460
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 61.6 bits (148), Expect = 8e-10 Identities = 46/138 (33%), Positives = 74/138 (53%), Gaps = 1/138 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTLATGQLVAVKRSQ-EGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G IG G FG V +G GQ VAVK + + + Q L+ E +++++ H+N+V L+G Sbjct: 238 GAQIGEGEFGAVLQGEYL-GQKVAVKNIKCDVTAQAFLD---ETAVMTKMQHENLVRLLG 293 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 L QG +V E++ G L L + ++ + L+ L A+G+ YL +V Sbjct: 294 VILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLES---KKLV 349 Query: 383 HRDIKSSNVLLDERLNAK 436 HRD+ + N+L+ E L AK Sbjct: 350 HRDLAARNILVSEDLVAK 367
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 61.6 bits (148), Expect = 8e-10 Identities = 38/138 (27%), Positives = 73/138 (52%), Gaps = 4/138 (2%) Frame = +2 Query: 35 IGNGGFGKVYRGTLA-TGQLVAVKRSQEGSL---QGSLEFRTEIELLSRVHHKNVVSLVG 202 +G G +GKV R T +G++VA+K ++ + Q + R EIE++S ++H +++S+ Sbjct: 61 LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYE 120 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 ++ + +++ EY G L + ++ + RL + + Y H+ +V Sbjct: 121 VFENKDKIVIIMEYASKGELYDYISERR--RLSERETRHFFRQIVSAVHYCHKNG---VV 175 Query: 383 HRDIKSSNVLLDERLNAK 436 HRD+K N+LLD+ N K Sbjct: 176 HRDLKLENILLDDNCNIK 193
>JAK3_HUMAN (P52333) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3)| (JAK-3) (Leukocyte janus kinase) (L-JAK) Length = 1124 Score = 61.6 bits (148), Expect = 8e-10 Identities = 46/143 (32%), Positives = 67/143 (46%), Gaps = 7/143 (4%) Frame = +2 Query: 29 NDIGNGGFGKVYRGTLA-----TGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 + +G G FG V TG LVAVK+ Q +F+ EI++L +H +V Sbjct: 826 SQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVK 885 Query: 194 LVGFCLDQGEQML--VYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELA 367 G G Q L V EY+P+G L++ L + RLD R L KG+ YL Sbjct: 886 YRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ-RHRARLDASRLLLYSSQICKGMEYL---G 941 Query: 368 DPPIVHRDIKSSNVLLDERLNAK 436 VHRD+ + N+L++ + K Sbjct: 942 SRRCVHRDLAARNILVESEAHVK 964 Score = 40.0 bits (92), Expect = 0.003 Identities = 38/139 (27%), Positives = 65/139 (46%), Gaps = 11/139 (7%) Frame = +2 Query: 32 DIGNGGFGKVYRG---------TLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKN 184 ++G+G F K+YRG T L+ V ++ + S F L+S+V +++ Sbjct: 526 NLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMES--FLEAASLMSQVSYRH 583 Query: 185 VVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSG-VRLDWKRRLRVILGTAKGIAY-LH 358 +V L G C+ G+ +V E++ G + L + V WK L K +AY L+ Sbjct: 584 LVLLHGVCM-AGDSTMVQEFVHLGAIDMYLRKRGHLVPASWK------LQVVKQLAYALN 636 Query: 359 ELADPPIVHRDIKSSNVLL 415 L D + H ++ + VLL Sbjct: 637 YLEDKGLPHGNVSARKVLL 655
>7LESS_DROVI (P20806) Protein sevenless (EC 2.7.10.1)| Length = 2594 Score = 61.6 bits (148), Expect = 8e-10 Identities = 43/140 (30%), Positives = 70/140 (50%), Gaps = 11/140 (7%) Frame = +2 Query: 35 IGNGGFGKVYRGTL-----ATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLV 199 +G+G FG+VY G L A Q VA+K ++G+ + + E E +L+S H+N+V L+ Sbjct: 2230 LGSGAFGEVYEGQLQAEDEAQPQRVAIKSLRKGASEFA-ELLQEAQLMSNFKHENIVCLI 2288 Query: 200 GFCLDQGEQMLVYEYIPNGTLKESL------TGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 G C D L+ E++ G L L + ++ +L L + L A G +Y+ Sbjct: 2289 GICCDTDSISLIMEHMEAGDLLSYLRAARPSSQEALSKLQLPELLSMCLDVANGCSYME- 2347 Query: 362 LADPPIVHRDIKSSNVLLDE 421 D VHRD+ N L+ + Sbjct: 2348 --DMHFVHRDLACRNCLVSD 2365
>AURKB_HUMAN (Q96GD4) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1) (Aurora-B) Length = 344 Score = 61.2 bits (147), Expect = 1e-09 Identities = 42/139 (30%), Positives = 66/139 (47%), Gaps = 4/139 (2%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGTLATGQ-LVAVK---RSQEGSLQGSLEFRTEIELLSRVHH 178 ++F G +G G FG VY +VA+K +SQ + R EIE+ + +HH Sbjct: 75 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 134 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLH 358 N++ L + D+ L+ EY P G L + L + D +R ++ A + Y H Sbjct: 135 PNILRLYNYFYDRRRIYLILEYAPRGELYKEL--QKSCTFDEQRTATIMEELADALMYCH 192 Query: 359 ELADPPIVHRDIKSSNVLL 415 ++HRDIK N+LL Sbjct: 193 ---GKKVIHRDIKPENLLL 208
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 61.2 bits (147), Expect = 1e-09 Identities = 43/140 (30%), Positives = 70/140 (50%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQ-----LVAVKRSQEGSLQGS-LEFRTEIELLSRVHHKNVVSL 196 IG G FG+VY+G L T VA+K + G + ++F E ++ + H N++ L Sbjct: 619 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRL 678 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G M++ EY+ NG L + L K G + + ++ G A G+ Y LA+ Sbjct: 679 EGVISKYKPMMIITEYMENGALDKFLREKDG-EFSVLQLVGMLRGIAAGMKY---LANMN 734 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N+L++ L K Sbjct: 735 YVHRDLAARNILVNSNLVCK 754
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 61.2 bits (147), Expect = 1e-09 Identities = 42/138 (30%), Positives = 65/138 (47%), Gaps = 4/138 (2%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRGTLATGQLV-AVK---RSQEGSLQGSLEFRTEIELLSRVHHK 181 +F G +G G FG VY + + A+K ++Q + R E+E+ S + H Sbjct: 123 DFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHP 182 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 N++ L G+ D L+ EY P GT+ L S + D +R I A ++Y H Sbjct: 183 NILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS--KFDEQRTATYITELANALSYCH- 239 Query: 362 LADPPIVHRDIKSSNVLL 415 ++HRDIK N+LL Sbjct: 240 --SKRVIHRDIKPENLLL 255
>TIE1_HUMAN (P35590) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1138 Score = 61.2 bits (147), Expect = 1e-09 Identities = 49/154 (31%), Positives = 74/154 (48%), Gaps = 20/154 (12%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQL---VAVKRSQE-GSLQGSLEFRTEIELLSRV-HHKNVVSLV 199 IG G FG+V R + L A+K +E S +F E+E+L ++ HH N+++L+ Sbjct: 845 IGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLL 904 Query: 200 GFCLDQGEQMLVYEYIPNGTLKESLTGKSGV---------------RLDWKRRLRVILGT 334 G C ++G + EY P G L + L KS V L ++ LR Sbjct: 905 GACKNRGYLYIAIEYAPYGNLLDFLR-KSRVLETDPAFAREHGTASTLSSRQLLRFASDA 963 Query: 335 AKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ YL E +HRD+ + NVL+ E L +K Sbjct: 964 ANGMQYLSE---KQFIHRDLAARNVLVGENLASK 994
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 61.2 bits (147), Expect = 1e-09 Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 4/139 (2%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGTLATGQ-LVAVK---RSQEGSLQGSLEFRTEIELLSRVHH 178 +NF G +G G FG VY + +VA+K +SQ + R EIE+ + + H Sbjct: 80 DNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKH 139 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLH 358 N++ L + DQ L+ EY P G L + L + D +R ++ + + Y H Sbjct: 140 PNILQLYNYFYDQQRIYLILEYAPRGELYKEL--QKSRTFDEQRTATIMEELSDALTYCH 197 Query: 359 ELADPPIVHRDIKSSNVLL 415 + ++HRDIK N+LL Sbjct: 198 K---KKVIHRDIKPENLLL 213
>ROR1_MOUSE (Q9Z139) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1) Length = 937 Score = 61.2 bits (147), Expect = 1e-09 Identities = 45/156 (28%), Positives = 75/156 (48%), Gaps = 21/156 (13%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLAT-----GQLVAVKRSQE-GSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G FGK+Y+G L QLVA+K ++ + Q EF+ E L++ +HH N+V Sbjct: 478 ELGECTFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVC 537 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESL---------------TGKSGVRLDWKRRLRVIL 328 L+G + +++EY+ G L E L G LD L + + Sbjct: 538 LLGAVTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAI 597 Query: 329 GTAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ Y L+ VH+D+ + N+L+ E+L+ K Sbjct: 598 QIAAGMEY---LSSHFFVHKDLAARNILIGEQLHVK 630
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 61.2 bits (147), Expect = 1e-09 Identities = 43/128 (33%), Positives = 65/128 (50%), Gaps = 1/128 (0%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG V + VA+K+ + S + + F E+ LSRV+H N+V L G CL+ Sbjct: 42 VGRGAFGVVCKAKWRAKD-VAIKQIESESERKA--FIVELRQLSRVNHPNIVKLYGACLN 98 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRL-DWKRRLRVILGTAKGIAYLHELADPPIVHRD 391 LV EY G+L L G + + L ++G+AYLH + ++HRD Sbjct: 99 P--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRD 156 Query: 392 IKSSNVLL 415 +K N+LL Sbjct: 157 LKPPNLLL 164
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 61.2 bits (147), Expect = 1e-09 Identities = 45/140 (32%), Positives = 68/140 (48%), Gaps = 3/140 (2%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTL-ATGQLVAVKRSQEGSLQGSLE--FRTEIELLSRVHHKNVVSL 196 G IG G FG+V+ G L A VAVK +E +L L+ F E +L + +H N+V L Sbjct: 275 GERIGRGNFGEVFSGRLRADNTPVAVKSCRE-TLPPELKAKFLQEARILKQYNHPNIVRL 333 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 +G C + +V E + G L K G L K ++++ A G+ YL Sbjct: 334 IGVCTQKQPIYIVMELVQGGDFLSFLRSK-GPHLKMKELIKMMENAAAGMEYLE---SKH 389 Query: 377 IVHRDIKSSNVLLDERLNAK 436 +HRD+ + N L+ E+ K Sbjct: 390 CIHRDLAARNCLVTEKNTLK 409
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 61.2 bits (147), Expect = 1e-09 Identities = 43/128 (33%), Positives = 65/128 (50%), Gaps = 1/128 (0%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG V + VA+K+ + S + + F E+ LSRV+H N+V L G CL+ Sbjct: 42 VGRGAFGVVCKAKWRAKD-VAIKQIESESERKA--FIVELRQLSRVNHPNIVKLYGACLN 98 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRL-DWKRRLRVILGTAKGIAYLHELADPPIVHRD 391 LV EY G+L L G + + L ++G+AYLH + ++HRD Sbjct: 99 P--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRD 156 Query: 392 IKSSNVLL 415 +K N+LL Sbjct: 157 LKPPNLLL 164
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 60.8 bits (146), Expect = 1e-09 Identities = 39/134 (29%), Positives = 71/134 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ HK +V L + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHKKLVQLYAVVSE 330 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G+ G L + + + A G+AY+ + VHRD+ Sbjct: 331 E-PIYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDL 386 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 387 RAANILVGENLVCK 400
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 60.8 bits (146), Expect = 1e-09 Identities = 38/136 (27%), Positives = 64/136 (47%), Gaps = 1/136 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G +G G FG+ + T TG+++ +K + F E++++ + H NV+ +G Sbjct: 342 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIG 401 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 + EYI GTL+ + + W +R+ A G+AYLH + I+ Sbjct: 402 VLYKDKRLNFITEYIKGGTLRGIIKSMDS-QYPWSQRVSFAKDIASGMAYLHSM---NII 457 Query: 383 HRDIKSSNVLLDERLN 430 HRD+ S N L+ E N Sbjct: 458 HRDLNSHNCLVRENRN 473
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 60.8 bits (146), Expect = 1e-09 Identities = 38/136 (27%), Positives = 64/136 (47%), Gaps = 1/136 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G +G G FG+ + T TG+++ +K + F E++++ + H NV+ +G Sbjct: 342 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIG 401 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 + EYI GTL+ + + W +R+ A G+AYLH + I+ Sbjct: 402 VLYKDKRLNFITEYIKGGTLRGIIKNMDS-QYPWSQRVSFAKDIASGMAYLHSM---NII 457 Query: 383 HRDIKSSNVLLDERLN 430 HRD+ S N L+ E N Sbjct: 458 HRDLNSHNCLVRENRN 473
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 60.8 bits (146), Expect = 1e-09 Identities = 38/136 (27%), Positives = 64/136 (47%), Gaps = 1/136 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G +G G FG+ + T TG+++ +K + F E++++ + H NV+ +G Sbjct: 342 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIG 401 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 + EYI GTL+ + + W +R+ A G+AYLH + I+ Sbjct: 402 VLYKDKRLNFITEYIKGGTLRGIIKSMDS-QYPWSQRVSFAKDIASGMAYLHSM---NII 457 Query: 383 HRDIKSSNVLLDERLN 430 HRD+ S N L+ E N Sbjct: 458 HRDLNSHNCLVRENKN 473
>PAKM_DROME (Q9VXE5) Serine/threonine-protein kinase PAK mbt (EC 2.7.11.1)| (p21-activated kinase-related protein) (Protein mushroom bodies tiny) Length = 639 Score = 60.8 bits (146), Expect = 1e-09 Identities = 44/135 (32%), Positives = 63/135 (46%), Gaps = 1/135 (0%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVV 190 N N IG G G V T +TG+ VAVK+ Q E+ ++ HH N+V Sbjct: 367 NLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIV 426 Query: 191 SLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELAD 370 L E +V EY+ G L + +T R+D ++ V K +AYLH Sbjct: 427 ETYSSFLVNDELWVVMEYLEGGALTDIVTHS---RMDEEQIATVCKQCLKALAYLHSQG- 482 Query: 371 PPIVHRDIKSSNVLL 415 ++HRDIKS ++LL Sbjct: 483 --VIHRDIKSDSILL 495
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 60.8 bits (146), Expect = 1e-09 Identities = 43/153 (28%), Positives = 73/153 (47%), Gaps = 19/153 (12%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQL---VAVKRSQE-GSLQGSLEFRTEIELLSRV-HHKNVVSLV 199 IG G FG+V + + L A+KR +E S +F E+E+L ++ HH N+++L+ Sbjct: 831 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 890 Query: 200 GFCLDQGEQMLVYEYIPNGTLKE--------------SLTGKSGVRLDWKRRLRVILGTA 337 G C +G L EY P+G L + ++ + L ++ L A Sbjct: 891 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 950 Query: 338 KGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 +G+ Y L+ +HRD+ + N+L+ E AK Sbjct: 951 RGMDY---LSQKQFIHRDLAARNILVGENYVAK 980
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 60.8 bits (146), Expect = 1e-09 Identities = 49/154 (31%), Positives = 74/154 (48%), Gaps = 20/154 (12%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQL---VAVKRSQE-GSLQGSLEFRTEIELLSRV-HHKNVVSLV 199 IG G FG+V R + L A+K +E S +F E+E+L ++ HH N+++L+ Sbjct: 841 IGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLL 900 Query: 200 GFCLDQGEQMLVYEYIPNGTLKESLTGKSGV---------------RLDWKRRLRVILGT 334 G C ++G + EY P G L + L KS V L ++ LR Sbjct: 901 GACENRGYLYIAIEYAPYGNLLDFLR-KSRVLETDPAFAREHGTASTLSSRQLLRFASDA 959 Query: 335 AKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ YL E +HRD+ + NVL+ E L +K Sbjct: 960 ANGMQYLSE---KQFIHRDLAARNVLVGENLASK 990
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 60.8 bits (146), Expect = 1e-09 Identities = 43/153 (28%), Positives = 73/153 (47%), Gaps = 19/153 (12%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQL---VAVKRSQE-GSLQGSLEFRTEIELLSRV-HHKNVVSLV 199 IG G FG+V + + L A+KR +E S +F E+E+L ++ HH N+++L+ Sbjct: 828 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 887 Query: 200 GFCLDQGEQMLVYEYIPNGTLKE--------------SLTGKSGVRLDWKRRLRVILGTA 337 G C +G L EY P+G L + ++ + L ++ L A Sbjct: 888 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 947 Query: 338 KGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 +G+ Y L+ +HRD+ + N+L+ E AK Sbjct: 948 RGMDY---LSQKQFIHRDLAARNILVGENYIAK 977
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 60.8 bits (146), Expect = 1e-09 Identities = 49/154 (31%), Positives = 74/154 (48%), Gaps = 20/154 (12%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQL---VAVKRSQE-GSLQGSLEFRTEIELLSRV-HHKNVVSLV 199 IG G FG+V R + L A+K +E S +F E+E+L ++ HH N+++L+ Sbjct: 843 IGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLL 902 Query: 200 GFCLDQGEQMLVYEYIPNGTLKESLTGKSGV---------------RLDWKRRLRVILGT 334 G C ++G + EY P G L + L KS V L ++ LR Sbjct: 903 GACENRGYLYIAIEYAPYGNLLDFLR-KSRVLETDPAFAREHGTASTLSSRQLLRFASDA 961 Query: 335 AKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ YL E +HRD+ + NVL+ E L +K Sbjct: 962 ANGMQYLSE---KQFIHRDLAARNVLVGENLASK 992
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 60.8 bits (146), Expect = 1e-09 Identities = 43/153 (28%), Positives = 73/153 (47%), Gaps = 19/153 (12%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQL---VAVKRSQE-GSLQGSLEFRTEIELLSRV-HHKNVVSLV 199 IG G FG+V + + L A+KR +E S +F E+E+L ++ HH N+++L+ Sbjct: 830 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 889 Query: 200 GFCLDQGEQMLVYEYIPNGTLKE--------------SLTGKSGVRLDWKRRLRVILGTA 337 G C +G L EY P+G L + ++ + L ++ L A Sbjct: 890 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 949 Query: 338 KGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 +G+ Y L+ +HRD+ + N+L+ E AK Sbjct: 950 RGMDY---LSQKQFIHRDLAARNILVGENYVAK 979
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 60.8 bits (146), Expect = 1e-09 Identities = 42/138 (30%), Positives = 66/138 (47%), Gaps = 4/138 (2%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRGTLATGQLV-AVKRSQEGSLQGS---LEFRTEIELLSRVHHK 181 +F G +G G FG VY + + A+K + L+ + + R E+E+ S + H Sbjct: 132 DFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHP 191 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 N++ L G+ D L+ EY P GT+ L S + D +R I A ++Y H Sbjct: 192 NILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS--KFDEQRTATYITELANALSYCH- 248 Query: 362 LADPPIVHRDIKSSNVLL 415 ++HRDIK N+LL Sbjct: 249 --SKRVIHRDIKPENLLL 264
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 60.8 bits (146), Expect = 1e-09 Identities = 42/138 (30%), Positives = 64/138 (46%), Gaps = 4/138 (2%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRGTLATGQLV-AVK---RSQEGSLQGSLEFRTEIELLSRVHHK 181 +F G +G G FG VY + + A+K +SQ + R E+E+ S + H Sbjct: 139 DFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHP 198 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 N++ L G+ D L+ +Y P G L L + R D +R I A+ + Y H Sbjct: 199 NILRLYGYFHDASRVYLILDYAPGGELFREL--QKCTRFDDQRSAMYIKQLAEALLYCH- 255 Query: 362 LADPPIVHRDIKSSNVLL 415 ++HRDIK N+LL Sbjct: 256 --SKKVIHRDIKPENLLL 271
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 60.8 bits (146), Expect = 1e-09 Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 7/141 (4%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVY-------RGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRV 172 +F G +G G FG VY + LA L V+ + G + R E+E+ S + Sbjct: 125 DFDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKVQLEKAGVEH---QLRREVEIQSHL 181 Query: 173 HHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAY 352 H N++ L G+ D L+ EY P GT+ L S + D +R I A ++Y Sbjct: 182 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS--KFDEQRTATYITELANALSY 239 Query: 353 LHELADPPIVHRDIKSSNVLL 415 H ++HRDIK N+LL Sbjct: 240 CH---SKRVIHRDIKPENLLL 257
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 60.5 bits (145), Expect = 2e-09 Identities = 45/138 (32%), Positives = 72/138 (52%), Gaps = 1/138 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTLATGQLVAVKRSQ-EGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G IG G FG V +G GQ VAVK + + + Q L+ E +++++ H+N+V L+G Sbjct: 197 GAQIGEGEFGAVLQGEYL-GQKVAVKNIKCDVTAQAFLD---ETAVMTKLQHRNLVRLLG 252 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 L G +V E++ G L L + + + L+ L A+G+ YL +V Sbjct: 253 VILHHG-LYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLES---KKLV 308 Query: 383 HRDIKSSNVLLDERLNAK 436 HRD+ + N+L+ E L AK Sbjct: 309 HRDLAARNILVSEDLVAK 326
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 60.5 bits (145), Expect = 2e-09 Identities = 42/138 (30%), Positives = 64/138 (46%), Gaps = 4/138 (2%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRGTLATGQLV-AVK---RSQEGSLQGSLEFRTEIELLSRVHHK 181 +F G +G G FG VY + + A+K +SQ + R E+E+ S + H Sbjct: 139 DFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHP 198 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 N++ L G+ D L+ +Y P G L L + R D +R I A+ + Y H Sbjct: 199 NILRLYGYFHDASRVYLILDYAPGGELFREL--QKCTRFDDQRSALYIKQLAEALLYCH- 255 Query: 362 LADPPIVHRDIKSSNVLL 415 ++HRDIK N+LL Sbjct: 256 --SKKVIHRDIKPENLLL 271
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 60.5 bits (145), Expect = 2e-09 Identities = 45/138 (32%), Positives = 72/138 (52%), Gaps = 1/138 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTLATGQLVAVKRSQ-EGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G IG G FG V +G GQ VAVK + + + Q L+ E +++++ H+N+V L+G Sbjct: 236 GAQIGEGEFGAVLQGEYL-GQKVAVKNIKCDVTAQAFLD---ETAVMTKLQHRNLVRLLG 291 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 L G +V E++ G L L + + + L+ L A+G+ YL +V Sbjct: 292 VILHHG-LYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLES---KKLV 347 Query: 383 HRDIKSSNVLLDERLNAK 436 HRD+ + N+L+ E L AK Sbjct: 348 HRDLAARNILVSEDLVAK 365
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 60.5 bits (145), Expect = 2e-09 Identities = 35/129 (27%), Positives = 68/129 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G+G FG+V+ G VAVK + GS+ + +F E +++ + H ++ L C Sbjct: 240 LGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPN-DFLREAQIMKNLRHPKLIQLYAVCTL 298 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + ++ E + +G+L+E L +G ++ +++ + A G+AYL +HRD+ Sbjct: 299 EDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLE---SRNYIHRDL 355 Query: 395 KSSNVLLDE 421 + NVL+ E Sbjct: 356 AARNVLVGE 364
>GCY3E_DROME (Q07553) Guanylate cyclase 32E precursor (EC 4.6.1.2)| Length = 1163 Score = 60.5 bits (145), Expect = 2e-09 Identities = 34/117 (29%), Positives = 63/117 (53%) Frame = +2 Query: 74 LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPN 253 L G +VA+K+ + S+ + R E++L+ V H+N+++ +G D G ++ Y Sbjct: 550 LFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCAR 609 Query: 254 GTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDIKSSNVLLDER 424 G+L++ L + + LD ++ KG+ YLH+ I H +++SSN L+D R Sbjct: 610 GSLEDVLANED-LHLDHMFISSLVSDILKGMIYLHD--SEIISHGNLRSSNCLIDSR 663
>M3K4_HUMAN (Q9Y6R4) Mitogen-activated protein kinase kinase kinase 4 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1) Length = 1607 Score = 60.5 bits (145), Expect = 2e-09 Identities = 46/141 (32%), Positives = 71/141 (50%), Gaps = 3/141 (2%) Frame = +2 Query: 2 KITNNFSEGNDIGNGGFGKVYRG-TLATGQLVAVK--RSQEGSLQGSLEFRTEIELLSRV 172 K+T + GN IG G +GKVY ++ TG+L+A+K R Q + E E+++ + Sbjct: 1337 KVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI 1396 Query: 173 HHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAY 352 H N+V G L + E + EY GTL+E RL + + + IA Sbjct: 1397 KHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV------SRLGLQEHVIRLYSKQITIA- 1449 Query: 353 LHELADPPIVHRDIKSSNVLL 415 ++ L + IVHRDIK +N+ L Sbjct: 1450 INVLHEHGIVHRDIKGANIFL 1470
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 60.5 bits (145), Expect = 2e-09 Identities = 49/154 (31%), Positives = 72/154 (46%), Gaps = 19/154 (12%) Frame = +2 Query: 32 DIGNGGFGKVYRG---TLATGQ---LVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G G FGKV+ L Q LVAVK +E S +F E ELL+ + H+++V Sbjct: 518 ELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVR 577 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLK----------ESLTGKSGVR---LDWKRRLRVILGT 334 G C + G ++V+EY+ +G L + L G V L + L V Sbjct: 578 FFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQV 637 Query: 335 AKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ YL L VHRD+ + N L+ + L K Sbjct: 638 AAGMVYLASL---HFVHRDLATRNCLVGQGLVVK 668
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 60.5 bits (145), Expect = 2e-09 Identities = 43/138 (31%), Positives = 73/138 (52%), Gaps = 4/138 (2%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSL-QGSLE--FRTEIELLSRVHHK 181 +F G +G G FG+VY + +G + A+K ++ + Q ++E FR E+E+ S + H Sbjct: 108 DFEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQFRREVEIQSSLRHP 167 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 N+ L G+ D+ L+ EY+ NG L + L G+S + + A + Y+HE Sbjct: 168 NLTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRS--HFNDVVASYYVYQMADALDYMHE 225 Query: 362 LADPPIVHRDIKSSNVLL 415 I+HRDIK N+++ Sbjct: 226 ---RNILHRDIKPENIII 240
>M3K1_HUMAN (Q13233) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (Fragment) Length = 1495 Score = 60.5 bits (145), Expect = 2e-09 Identities = 41/143 (28%), Positives = 75/143 (52%), Gaps = 11/143 (7%) Frame = +2 Query: 23 EGNDIGNGGFGKVYRGT-LATGQLVAVK-----RSQEGSLQGSLE-FRTEIELLSRVHHK 181 +G IG G F Y+ + TG L+AVK R+ + +E R EI ++S ++H Sbjct: 1228 KGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHP 1287 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTG----KSGVRLDWKRRLRVILGTAKGIA 349 N++ ++G ++ L E++ G++ L+ K V +++ +L +G++ Sbjct: 1288 NIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQL------LRGLS 1341 Query: 350 YLHELADPPIVHRDIKSSNVLLD 418 YLHE I+HRD+K +N+L+D Sbjct: 1342 YLHE---NQIIHRDVKGANLLID 1361
>BLK_MOUSE (P16277) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 498 Score = 60.5 bits (145), Expect = 2e-09 Identities = 38/134 (28%), Positives = 69/134 (51%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G+G FG+V+ G VA+K +EG++ F E ++ + H+ +V L + Sbjct: 240 LGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEA-FLGEANVMKTLQHERLVRLYAV-VT 297 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G L + L G RL R + + A+G+AY+ + +HRD+ Sbjct: 298 REPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQVAEGMAYIERMNS---IHRDL 354 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 355 RAANILVSETLCCK 368
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 60.5 bits (145), Expect = 2e-09 Identities = 44/154 (28%), Positives = 71/154 (46%), Gaps = 19/154 (12%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLA------TGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G G FGKV+ + LVAVK +E + L+F+ E ELL+ + H+++V Sbjct: 498 ELGEGAFGKVFLAECSHLLPEQEKTLVAVKALKEVTENARLDFQREAELLTVLQHEHIVK 557 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESL-------------TGKSGVRLDWKRRLRVILGT 334 G C + ++V+EY+ +G L L G+ +L L++ Sbjct: 558 FYGVCTEGDPLIMVFEYMKHGDLNRFLRSHGPDAKILDQGQGQPCGQLTLSHMLQIATQI 617 Query: 335 AKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ YL L VHRD+ + N L+ L K Sbjct: 618 ASGMVYLASL---HFVHRDLATRNCLVGHDLVVK 648
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 60.5 bits (145), Expect = 2e-09 Identities = 38/134 (28%), Positives = 71/134 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 269 LGQGYFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAMVSE 327 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G+ G L + + + A G+AY+ + VHRD+ Sbjct: 328 E-PIYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVEMAAQIASGMAYVERM---NYVHRDL 383 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 384 RAANILVGENLVCK 397
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 60.5 bits (145), Expect = 2e-09 Identities = 38/134 (28%), Positives = 69/134 (51%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G+G FG+V+ G VA+K +EG++ F E ++ + H+ +V L + Sbjct: 246 LGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPE-AFLGEANMMKALQHERLVRLYA-VVT 303 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G L + L G RL R + + A+G+AY+ + +HRD+ Sbjct: 304 KEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNS---IHRDL 360 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 361 RAANILVSEALCCK 374
>JAK1_BRARE (O12990) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1153 Score = 60.1 bits (144), Expect = 2e-09 Identities = 46/144 (31%), Positives = 74/144 (51%), Gaps = 9/144 (6%) Frame = +2 Query: 32 DIGNGGFGKVY------RGTLATGQLVAVKRSQ-EGSLQGSLEFRTEIELLSRVHHKNVV 190 D+G G FGKV RG TG+LVAVK + E + S EI +L ++H+N+V Sbjct: 877 DLGEGHFGKVELCRYDPRGD-RTGELVAVKSLKPENREEQSNNLWREIHILRELYHENIV 935 Query: 191 SLVGFCLDQGEQ--MLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHEL 364 G C ++G + L+ E++P G+LKE L ++ ++ K + +G+ Y L Sbjct: 936 KYKGICNEEGGRSIKLIMEFLPAGSLKEYLP-RNKAHINLKTLHNYSVQICQGMDY---L 991 Query: 365 ADPPIVHRDIKSSNVLLDERLNAK 436 +HRD+ + NVL++ K Sbjct: 992 GSRNYIHRDLAARNVLVENEGTVK 1015 Score = 37.7 bits (86), Expect = 0.012 Identities = 33/144 (22%), Positives = 57/144 (39%), Gaps = 13/144 (9%) Frame = +2 Query: 23 EGNDIGNGGFGKVYRGTLATGQ-------------LVAVKRSQEGSLQGSLEFRTEIELL 163 +G +G G +Y G L V +K G SL F ++ Sbjct: 582 QGEHLGRGTRTNIYAGILKPKSDDEDDLGGYSQEVKVVLKVLGSGHRDISLAFFETASMM 641 Query: 164 SRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKG 343 ++ HK+ L G C+ E ++V E++ G L + + L + +V A Sbjct: 642 RQISHKHTALLYGVCVRHQENIMVEEFVQYGPL-DLFMRRQTTPLSTAWKFQVAKQLASA 700 Query: 344 IAYLHELADPPIVHRDIKSSNVLL 415 ++YL D +VH + S N+L+ Sbjct: 701 LSYLE---DKKMVHGYVCSKNILV 721
>STE11_YEAST (P23561) Serine/threonine-protein kinase STE11 (EC 2.7.11.1)| Length = 738 Score = 60.1 bits (144), Expect = 2e-09 Identities = 48/184 (26%), Positives = 82/184 (44%), Gaps = 49/184 (26%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVYRGTLA-TGQLVAVKR-----------------------SQEGS 121 N+ +G IG+G FG VY G A TG+L+AVK+ +++ Sbjct: 435 NWLKGACIGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEE 494 Query: 122 LQGSLE---------------------FRTEIELLSRVHHKNVVSLVGFCLDQGEQMLVY 238 Q +E + E+ LL +HH+N+V+ G + G + Sbjct: 495 QQEKIEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFL 554 Query: 239 EYIPNGTLKESLTG----KSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDIKSSN 406 EY+P G++ L + + ++ R++ + G+AYLH+ I+HRDIK +N Sbjct: 555 EYVPGGSVSSMLNNYGPFEESLITNFTRQILI------GVAYLHK---KNIIHRDIKGAN 605 Query: 407 VLLD 418 +L+D Sbjct: 606 ILID 609
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 820 Score = 60.1 bits (144), Expect = 2e-09 Identities = 45/136 (33%), Positives = 67/136 (49%), Gaps = 3/136 (2%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGTL-ATGQLVAVKRSQEGSLQGSLE--FRTEIELLSRVHHKNVVSL 196 G IG G FG+V+ G L A VAVK +E +L L+ F E +L + +H N+V L Sbjct: 562 GEQIGRGNFGEVFSGRLRADNTPVAVKSCRE-TLPPDLKAKFLQEARILKQYNHPNIVRL 620 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 +G C + +V E + G L G RL K L+++ A G+ YL Sbjct: 621 IGVCTQKQPIYIVMELVQGGDFLTFLR-TEGARLRVKTLLQMMGDAAAGMEYLESKC--- 676 Query: 377 IVHRDIKSSNVLLDER 424 +HRD+ + N L+ E+ Sbjct: 677 CIHRDLAARNCLVTEK 692
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 60.1 bits (144), Expect = 2e-09 Identities = 41/131 (31%), Positives = 62/131 (47%), Gaps = 2/131 (1%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSLVGFC 208 IG GGF KV + TG++VA+K + +L L +TEIE L + H+++ L Sbjct: 17 IGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVL 76 Query: 209 LDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHR 388 + +V EY P G L + + + RL + V +AY+H HR Sbjct: 77 ETANKIFMVLEYCPGGELFDYIISQD--RLSEEETRVVFRQIVSAVAYVHSQG---YAHR 131 Query: 389 DIKSSNVLLDE 421 D+K N+L DE Sbjct: 132 DLKPENLLFDE 142
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 60.1 bits (144), Expect = 2e-09 Identities = 46/140 (32%), Positives = 70/140 (50%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQL-VAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 +G GGFG V+R L VAVK + S + E++ + + H+NV+ L+G Sbjct: 28 VGKGGFGAVFRARHTAWNLDVAVK------IVNSKKISREVKAMVNLRHENVLLLLGVTE 81 Query: 212 DQGEQM-----LVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 + LV ++ NG+L L + W R++ G+ YLH L +P Sbjct: 82 NLEWDYVYGPALVTGFMENGSLSGLL--QPSCPRPWPLLCRLLEEVVLGMCYLHSL-NPS 138 Query: 377 IVHRDIKSSNVLLDERLNAK 436 ++HRD+K SNVLLD L+AK Sbjct: 139 LLHRDLKPSNVLLDLELHAK 158
>JAK1_CYPCA (Q09178) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1156 Score = 60.1 bits (144), Expect = 2e-09 Identities = 47/144 (32%), Positives = 74/144 (51%), Gaps = 9/144 (6%) Frame = +2 Query: 32 DIGNGGFGKVY------RGTLATGQLVAVKRSQ-EGSLQGSLEFRTEIELLSRVHHKNVV 190 D+G G FGKV RG TG+LVAVK + E + S EI +L ++H+N+V Sbjct: 880 DLGEGHFGKVELCRYDPRGD-RTGELVAVKSLKPENREEQSSNLWREIHILRELYHENIV 938 Query: 191 SLVGFCLDQGEQM--LVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHEL 364 G ++G + L+ E++P G+LKE L ++ +D K L + +G+ L Sbjct: 939 KYKGIWHEEGGRSIKLIMEFLPAGSLKEYLP-RNKAHIDLKTLLNYAVQICQGMDLL--- 994 Query: 365 ADPPIVHRDIKSSNVLLDERLNAK 436 A +HRD+ + NVL++ K Sbjct: 995 ASRNYIHRDLAARNVLVENENTVK 1018 Score = 42.0 bits (97), Expect = 7e-04 Identities = 33/144 (22%), Positives = 60/144 (41%), Gaps = 13/144 (9%) Frame = +2 Query: 23 EGNDIGNGGFGKVYRGTLATGQ-------------LVAVKRSQEGSLQGSLEFRTEIELL 163 +G +G G +Y G L V +K G SL F ++ Sbjct: 585 QGEHLGRGTRTNIYSGVLKLKSEDDDDMGGYSQEVKVILKVLGSGHRDISLAFFETASMM 644 Query: 164 SRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKG 343 ++ HK++ L G C+ E ++V E++ G L + + + L + +V A Sbjct: 645 RQISHKHIALLYGVCVRHQENIMVEEFVQYGPL-DLFMRRQSIPLSTAWKFQVAKQLAGA 703 Query: 344 IAYLHELADPPIVHRDIKSSNVLL 415 ++YL D +VH ++ S N+L+ Sbjct: 704 LSYLE---DKKLVHGNVCSKNILV 724
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 59.7 bits (143), Expect = 3e-09 Identities = 43/155 (27%), Positives = 70/155 (45%), Gaps = 20/155 (12%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLAT------GQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G G FGKV+ LVAVK ++ +L +F+ E ELL+ + H+++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESLTG--------------KSGVRLDWKRRLRVILG 331 G C D ++V+EY+ +G L + L ++ L + L + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 332 TAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ Y LA VHRD+ + N L+ L K Sbjct: 663 IASGMVY---LASQHFVHRDLATRNCLVGANLLVK 694
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 59.7 bits (143), Expect = 3e-09 Identities = 43/155 (27%), Positives = 70/155 (45%), Gaps = 20/155 (12%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLAT------GQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G G FGKV+ LVAVK ++ +L +F+ E ELL+ + H+++V Sbjct: 545 ELGEGAFGKVFLAECYNLSPTNDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 604 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESLTG--------------KSGVRLDWKRRLRVILG 331 G C D ++V+EY+ +G L + L ++ L + L + Sbjct: 605 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 664 Query: 332 TAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ Y LA VHRD+ + N L+ L K Sbjct: 665 IASGMVY---LASQHFVHRDLATRNCLVGANLLVK 696
>MET_CALMO (Q2QLC0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 59.7 bits (143), Expect = 3e-09 Identities = 48/140 (34%), Positives = 72/140 (51%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT--GQLV--AVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSLV 199 IG G FG VY GTL G+ + AVK + G + +F TE ++ H NV+SL+ Sbjct: 1084 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 1143 Query: 200 GFCL-DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G CL +G ++V Y+ +G L+ + ++ K + L AKG+ YL A Sbjct: 1144 GICLRSEGSPLVVLPYMKHGDLRNFIRNETH-NPTVKDLIGFGLQVAKGMKYL---ASKK 1199 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N +LDE+ K Sbjct: 1200 FVHRDLAARNCMLDEKFTVK 1219
>MET_CALJA (Q2QLG5) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 59.7 bits (143), Expect = 3e-09 Identities = 48/140 (34%), Positives = 72/140 (51%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT--GQLV--AVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSLV 199 IG G FG VY GTL G+ + AVK + G + +F TE ++ H NV+SL+ Sbjct: 1084 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 1143 Query: 200 GFCL-DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G CL +G ++V Y+ +G L+ + ++ K + L AKG+ YL A Sbjct: 1144 GICLRSEGSPLVVLPYMKHGDLRNFIRNETH-NPTVKDLIGFGLQVAKGMKYL---ASKK 1199 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N +LDE+ K Sbjct: 1200 FVHRDLAARNCMLDEKFTVK 1219
>MET_MOUSE (P16056) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1379 Score = 59.7 bits (143), Expect = 3e-09 Identities = 47/140 (33%), Positives = 73/140 (52%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT--GQLV--AVKR-SQEGSLQGSLEFRTEIELLSRVHHKNVVSLV 199 IG G FG VY GTL G+ + AVK ++ ++ +F TE ++ H NV+SL+ Sbjct: 1082 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLL 1141 Query: 200 GFCL-DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G CL +G ++V Y+ +G L+ + ++ K + L AKG+ YL A Sbjct: 1142 GICLRSEGSPLVVLPYMKHGDLRNFIRNETH-NPTVKDLIGFGLQVAKGMKYL---ASKK 1197 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N +LDE+ K Sbjct: 1198 FVHRDLAARNCMLDEKFTVK 1217
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 59.7 bits (143), Expect = 3e-09 Identities = 39/134 (29%), Positives = 71/134 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 271 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAVVSE 329 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EYI G+L + L G+ G L + + + A G+AY+ + VHRD+ Sbjct: 330 E-PIYIVTEYISKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERM---NYVHRDL 385 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 386 RAANILVGENLVCK 399
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 59.7 bits (143), Expect = 3e-09 Identities = 38/134 (28%), Positives = 71/134 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 272 LGQGCFGEVWMGTWNDTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAVVSE 330 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G+ G L + + + A G+AY+ + VHRD+ Sbjct: 331 E-PIYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDL 386 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 387 RAANILVGENLVCK 400
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 59.7 bits (143), Expect = 3e-09 Identities = 43/155 (27%), Positives = 70/155 (45%), Gaps = 20/155 (12%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLAT------GQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G G FGKV+ LVAVK ++ +L +F+ E ELL+ + H+++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESLTG--------------KSGVRLDWKRRLRVILG 331 G C D ++V+EY+ +G L + L ++ L + L + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 332 TAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ Y LA VHRD+ + N L+ L K Sbjct: 663 IASGMVY---LASQHFVHRDLATRNCLVGANLLVK 694
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 59.7 bits (143), Expect = 3e-09 Identities = 43/155 (27%), Positives = 70/155 (45%), Gaps = 20/155 (12%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLAT------GQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G G FGKV+ LVAVK ++ +L +F+ E ELL+ + H+++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESLTG--------------KSGVRLDWKRRLRVILG 331 G C D ++V+EY+ +G L + L ++ L + L + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 332 TAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ Y LA VHRD+ + N L+ L K Sbjct: 663 IASGMVY---LASQHFVHRDLATRNCLVGANLLVK 694
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 59.7 bits (143), Expect = 3e-09 Identities = 43/155 (27%), Positives = 70/155 (45%), Gaps = 20/155 (12%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLAT------GQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G G FGKV+ LVAVK ++ +L +F+ E ELL+ + H+++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESLTG--------------KSGVRLDWKRRLRVILG 331 G C D ++V+EY+ +G L + L ++ L + L + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 332 TAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G+ Y LA VHRD+ + N L+ L K Sbjct: 663 IASGMVY---LASQHFVHRDLATRNCLVGANLLVK 694
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 59.7 bits (143), Expect = 3e-09 Identities = 43/134 (32%), Positives = 67/134 (50%), Gaps = 5/134 (3%) Frame = +2 Query: 26 GNDIGNGGFGKVYRG-TLATGQLVAVKRSQEGSLQGS--LEFRTEIELLSRVHHKNVVSL 196 G+ +G G FG VYRG + G+ VAVK+ + + S + EI+LL + H N+V Sbjct: 12 GDCLGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVKY 71 Query: 197 VGFCLDQGEQMLVYEYIPNGTLKESLT--GKSGVRLDWKRRLRVILGTAKGIAYLHELAD 370 G ++ EY NG+L+ GK L +V+ +G+ YLH + Sbjct: 72 RGSYQTNDSLCIILEYCENGSLRSICKNFGKIPENLVALYTFQVL----QGLLYLH---N 124 Query: 371 PPIVHRDIKSSNVL 412 ++HRDIK +N+L Sbjct: 125 QGVIHRDIKGANIL 138
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 59.7 bits (143), Expect = 3e-09 Identities = 38/133 (28%), Positives = 63/133 (47%), Gaps = 1/133 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G +G G FG+ + T TG+++ +K + F E++++ + H NV+ +G Sbjct: 349 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIG 408 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 + + EYI GTL+ L W +R+ A G+AYLH + I+ Sbjct: 409 VLYKEKRLNFITEYIKGGTLR-GLIKSMDSHYPWSQRVSFAKDIAAGMAYLHSM---NII 464 Query: 383 HRDIKSSNVLLDE 421 HRD+ S N L+ E Sbjct: 465 HRDLNSHNCLVRE 477
>MET_PONPY (Q2IBD8) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 59.7 bits (143), Expect = 3e-09 Identities = 48/140 (34%), Positives = 72/140 (51%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT--GQLV--AVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSLV 199 IG G FG VY GTL G+ + AVK + G + +F TE ++ H NV+SL+ Sbjct: 1084 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 1143 Query: 200 GFCL-DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G CL +G ++V Y+ +G L+ + ++ K + L AKG+ YL A Sbjct: 1144 GICLRSEGSPLVVLPYMKHGDLRNFIRNETH-NPTVKDLIGFGLQVAKGMKYL---ASKK 1199 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N +LDE+ K Sbjct: 1200 FVHRDLAARNCMLDEKFTVK 1219
>MET_PANTR (Q2QLF1) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 59.7 bits (143), Expect = 3e-09 Identities = 48/140 (34%), Positives = 72/140 (51%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT--GQLV--AVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSLV 199 IG G FG VY GTL G+ + AVK + G + +F TE ++ H NV+SL+ Sbjct: 1084 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 1143 Query: 200 GFCL-DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G CL +G ++V Y+ +G L+ + ++ K + L AKG+ YL A Sbjct: 1144 GICLRSEGSPLVVLPYMKHGDLRNFIRNETH-NPTVKDLIGFGLQVAKGMKYL---ASKK 1199 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N +LDE+ K Sbjct: 1200 FVHRDLAARNCMLDEKFTVK 1219
>MET_MICMU (Q2QL89) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 59.7 bits (143), Expect = 3e-09 Identities = 48/140 (34%), Positives = 72/140 (51%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT--GQLV--AVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSLV 199 IG G FG VY GTL G+ + AVK + G + +F TE ++ H NV+SL+ Sbjct: 1085 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 1144 Query: 200 GFCL-DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G CL +G ++V Y+ +G L+ + ++ K + L AKG+ YL A Sbjct: 1145 GICLRSEGSPLVVLPYMKHGDLRNFIRNETH-NPTVKDLIGFGLQVAKGMKYL---ASKK 1200 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N +LDE+ K Sbjct: 1201 FVHRDLAARNCMLDEKFTVK 1220
>MET_HUMAN (P08581) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 59.7 bits (143), Expect = 3e-09 Identities = 48/140 (34%), Positives = 72/140 (51%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT--GQLV--AVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSLV 199 IG G FG VY GTL G+ + AVK + G + +F TE ++ H NV+SL+ Sbjct: 1084 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 1143 Query: 200 GFCL-DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G CL +G ++V Y+ +G L+ + ++ K + L AKG+ YL A Sbjct: 1144 GICLRSEGSPLVVLPYMKHGDLRNFIRNETH-NPTVKDLIGFGLQVAKGMKYL---ASKK 1199 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N +LDE+ K Sbjct: 1200 FVHRDLAARNCMLDEKFTVK 1219
>TNIK_HUMAN (Q9UKE5) TRAF2 and NCK-interacting kinase (EC 2.7.11.1)| Length = 1360 Score = 59.7 bits (143), Expect = 3e-09 Identities = 41/142 (28%), Positives = 72/142 (50%), Gaps = 8/142 (5%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRV-HHKNVVSLVGFC 208 +GNG +G+VY+G + TGQL A+K + + E + EI +L + HH+N+ + G Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIK-VMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAF 89 Query: 209 LDQG------EQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELAD 370 + + + LV E+ G++ + + G L + + +G+++LH+ Sbjct: 90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ--- 146 Query: 371 PPIVHRDIKSSNVLLDERLNAK 436 ++HRDIK NVLL E K Sbjct: 147 HKVIHRDIKGQNVLLTENAEVK 168
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 59.7 bits (143), Expect = 3e-09 Identities = 38/134 (28%), Positives = 72/134 (53%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 275 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAVVSE 333 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G++G L + + + A G+AY+ + VHRD+ Sbjct: 334 E-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDL 389 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 390 RAANILVGENLVCK 403
>TNIK_MOUSE (P83510) Traf2 and NCK-interacting kinase (EC 2.7.11.1) (Fragments)| Length = 916 Score = 59.7 bits (143), Expect = 3e-09 Identities = 41/142 (28%), Positives = 72/142 (50%), Gaps = 8/142 (5%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRV-HHKNVVSLVGFC 208 +GNG +G+VY+G + TGQL A+K + + E + EI +L + HH+N+ + G Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIK-VMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAF 89 Query: 209 LDQG------EQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELAD 370 + + + LV E+ G++ + + G L + + +G+++LH+ Sbjct: 90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ--- 146 Query: 371 PPIVHRDIKSSNVLLDERLNAK 436 ++HRDIK NVLL E K Sbjct: 147 HKVIHRDIKGQNVLLTENAEVK 168
>PHO85_CANAL (Q9HGY5) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) (CaPHO85) Length = 326 Score = 59.7 bits (143), Expect = 3e-09 Identities = 42/144 (29%), Positives = 71/144 (49%), Gaps = 5/144 (3%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRG-TLATGQLVAVKR----SQEGSLQGSLEFRTEIELLSRV 172 ++ F + +G G + VY+G ATG LVA+K S+EG+ ++ EI L+ + Sbjct: 5 SSQFQQLEKLGEGTYATVYKGRNRATGALVALKEISLDSEEGTPSTAIR---EISLMKEL 61 Query: 173 HHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAY 352 H+N+V+L + + LV+EY+ K LD K + KGI + Sbjct: 62 DHENIVTLYDVIHTENKLTLVFEYMDKDLKKYMEVHGQQSALDLKVVKSFMFQLLKGIMF 121 Query: 353 LHELADPPIVHRDIKSSNVLLDER 424 H D ++HRD+K N+L++ + Sbjct: 122 CH---DNRVLHRDLKPQNLLINNK 142
>MET_PIG (Q2QLE0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 59.3 bits (142), Expect = 4e-09 Identities = 47/140 (33%), Positives = 69/140 (49%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQ----LVAVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSLV 199 IG G FG VY GTL AVK + G + +F TE ++ H NV+SL+ Sbjct: 1084 IGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 1143 Query: 200 GFCL-DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G CL +G ++V Y+ +G L+ + ++ K + L AKG+ YL A Sbjct: 1144 GICLRSEGSPLVVLPYMKHGDLRNFIRNETH-NPTVKDLIGFGLQVAKGMKYL---ASKK 1199 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N +LDE+ K Sbjct: 1200 FVHRDLAARNCMLDEKFTVK 1219
>MET_HORSE (Q2QLA9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 59.3 bits (142), Expect = 4e-09 Identities = 47/140 (33%), Positives = 69/140 (49%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQ----LVAVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSLV 199 IG G FG VY GTL AVK + G + +F TE ++ H NV+SL+ Sbjct: 1084 IGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 1143 Query: 200 GFCL-DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G CL +G ++V Y+ +G L+ + ++ K + L AKG+ YL A Sbjct: 1144 GICLRSEGSPLVVLPYMKHGDLRNFIRNETH-NPTVKDLIGFGLQVAKGMKYL---ASKK 1199 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N +LDE+ K Sbjct: 1200 FVHRDLAARNCMLDEKFTVK 1219
>HOG1_DEBHA (Q9UV50) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 387 Score = 59.3 bits (142), Expect = 4e-09 Identities = 45/148 (30%), Positives = 74/148 (50%), Gaps = 3/148 (2%) Frame = +2 Query: 2 KITNNFSEGNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRT--EIELLSRV 172 +ITN +++ N +G G FG V TGQ VAVK+ + L L RT E++LL + Sbjct: 18 EITNRYTDLNPVGMGAFGLVCSAIDKLTGQNVAVKKIMKPFLTSVLAKRTYRELKLLKHL 77 Query: 173 HHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAY 352 H+N+++L L E + + L LT + + + IL +G+ Y Sbjct: 78 RHENLITLDDIFLSPLEDIYFVTELQGTDLHRLLTSRPLEKQFIQYFTYQIL---RGLKY 134 Query: 353 LHELADPPIVHRDIKSSNVLLDERLNAK 436 +H ++HRD+K SN+L++E + K Sbjct: 135 VHSAG---VIHRDLKPSNILINENCDLK 159
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 59.3 bits (142), Expect = 4e-09 Identities = 38/134 (28%), Positives = 71/134 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAVVSE 330 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G+ G L + + + A G+AY+ + VHRD+ Sbjct: 331 E-PIYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDL 386 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 387 RAANILVGENLVCK 400
>M4K4_HUMAN (O95819) Mitogen-activated protein kinase kinase kinase kinase 4| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase) Length = 1239 Score = 59.3 bits (142), Expect = 4e-09 Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 11/145 (7%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRV-HHKNVVSLVGFC 208 +GNG +G+VY+G + TGQL A+K + + E + EI +L + HH+N+ + G Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIK-VMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAF 89 Query: 209 LDQG------EQMLVYEYIPNGTLKESLTGKSGVRL--DWKRRL-RVILGTAKGIAYLHE 361 + + + LV E+ G++ + + G L DW + R IL +G+A+LH Sbjct: 90 IKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREIL---RGLAHLHI 146 Query: 362 LADPPIVHRDIKSSNVLLDERLNAK 436 ++HRDIK NVLL E K Sbjct: 147 ---HHVIHRDIKGQNVLLTENAEVK 168
>LIMK1_XENLA (O42565) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (xLIMK1)| Length = 615 Score = 59.3 bits (142), Expect = 4e-09 Identities = 36/133 (27%), Positives = 62/133 (46%), Gaps = 1/133 (0%) Frame = +2 Query: 26 GNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 G +G G FG+ + T TG+++ +K + F E++++ + H +V+ +G Sbjct: 317 GEVLGRGCFGQAIKVTHRVTGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPHVLKFIG 376 Query: 203 FCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIV 382 + EYIP GTL+ + W +R+ A G+ YLH + I+ Sbjct: 377 VLYKDKRLNFITEYIPGGTLRRVIKSMD-THCPWNQRVSFARDIAAGMTYLHSM---NII 432 Query: 383 HRDIKSSNVLLDE 421 HRD+ S N L+ E Sbjct: 433 HRDLNSHNCLVRE 445
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 59.3 bits (142), Expect = 4e-09 Identities = 41/144 (28%), Positives = 74/144 (51%), Gaps = 5/144 (3%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRG-TLATGQLVAVKR----SQEGSLQGSLEFRTEIELLSRV 172 ++ F + +G G + VY+G TGQLVA+K S+EG+ ++ EI L+ + Sbjct: 4 SSQFQQLEKLGEGTYATVYKGRNRTTGQLVALKEINLDSEEGTPSTAIR---EISLMKEL 60 Query: 173 HHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAY 352 H+N+V+L + + LV+EY+ K T + L+ K+ + +GI + Sbjct: 61 KHENIVTLYDVIHTENKLNLVFEYMDKDLKKFMDTNGNKGALETKQVKWFMYQLLRGILF 120 Query: 353 LHELADPPIVHRDIKSSNVLLDER 424 H D ++HRD+K N+L++ + Sbjct: 121 CH---DNRVLHRDLKPQNLLINAK 141
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 59.3 bits (142), Expect = 4e-09 Identities = 39/128 (30%), Positives = 65/128 (50%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 +IG+G FG V+ G VA+K EGS+ +F E +++ ++ H +V L G C+ Sbjct: 276 EIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEE-DFIEEAKVMMKLSHSRLVQLYGVCI 334 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRD 391 Q +V E++ NG L + L + G +L L + +G+AYL +HRD Sbjct: 335 QQKPLYIVTEFMENGCLLDYLRERKG-QLQKALLLSMCQDICEGMAYLERSC---YIHRD 390 Query: 392 IKSSNVLL 415 + + N L+ Sbjct: 391 LAARNCLV 398
>SHK1_SCHPO (P50527) Serine/threonine-protein kinase pak1/shk1 (EC 2.7.11.1)| Length = 658 Score = 59.3 bits (142), Expect = 4e-09 Identities = 42/128 (32%), Positives = 62/128 (48%), Gaps = 1/128 (0%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 IG G G VY + T VA+K+ EI ++ HHKN+V+ + Sbjct: 392 IGQGASGDVYSARQVGTNLSVAIKKMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDTFF 451 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRD 391 + E +V EY+ G+L E +T + L + + T +G+ +LHE IVHRD Sbjct: 452 YKSELWMVMEYMRGGSLTEVVTNNT---LSEGQIAAICKETLEGLQHLHENG---IVHRD 505 Query: 392 IKSSNVLL 415 IKS N+LL Sbjct: 506 IKSDNILL 513
>MET_CANFA (Q75ZY9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 59.3 bits (142), Expect = 4e-09 Identities = 47/140 (33%), Positives = 69/140 (49%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQ----LVAVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSLV 199 IG G FG VY GTL AVK + G + +F TE ++ H NV+SL+ Sbjct: 1085 IGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 1144 Query: 200 GFCL-DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G CL +G ++V Y+ +G L+ + ++ K + L AKG+ YL A Sbjct: 1145 GICLRSEGSPLVVLPYMKHGDLRNFIRNETH-NPTVKDLIGFGLQVAKGMKYL---ASKK 1200 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N +LDE+ K Sbjct: 1201 FVHRDLAARNCMLDEKFTVK 1220
>M3K6_HUMAN (O95382) Mitogen-activated protein kinase kinase kinase 6 (EC| 2.7.11.25) Length = 1011 Score = 59.3 bits (142), Expect = 4e-09 Identities = 46/133 (34%), Positives = 63/133 (47%), Gaps = 5/133 (3%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 +G G +G VY G T +A+K E + S EI L R+ HKN+V +G Sbjct: 377 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 436 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRL----RVILGTAKGIAYLHELADPPI 379 G + E +P G+L L G D + + R IL +G+ YLH D I Sbjct: 437 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQIL---QGLGYLH---DNHI 490 Query: 380 VHRDIKSSNVLLD 418 VHRDIK NVL++ Sbjct: 491 VHRDIKGDNVLIN 503
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 58.9 bits (141), Expect = 5e-09 Identities = 38/134 (28%), Positives = 71/134 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAVVSE 330 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G+ G L + + + A G+AY+ + VHRD+ Sbjct: 331 E-PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDL 386 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 387 RAANILVGENLVCK 400
>MINK1_HUMAN (Q8N4C8) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1332 Score = 58.9 bits (141), Expect = 5e-09 Identities = 42/142 (29%), Positives = 70/142 (49%), Gaps = 8/142 (5%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRV-HHKNVVSLVGFC 208 +GNG +G+VY+G + TGQL A+K + + E + EI +L + HH+N+ + G Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIK-VMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAF 89 Query: 209 LDQG------EQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELAD 370 + + + LV E+ G++ + + G L + +G+A+LH Sbjct: 90 IKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHA--- 146 Query: 371 PPIVHRDIKSSNVLLDERLNAK 436 ++HRDIK NVLL E K Sbjct: 147 HKVIHRDIKGQNVLLTENAEVK 168
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 58.9 bits (141), Expect = 5e-09 Identities = 39/129 (30%), Positives = 66/129 (51%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ G VAVK + G++ EF E ++ R+ H ++ L C Sbjct: 246 LGAGQFGEVWEGLWNGTTSVAVKTLKPGTMSVE-EFLQEASIMKRLRHPKLIQLYAVCTK 304 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V E + G+L E L G+ GV L ++ + V A G++YL + +HRD+ Sbjct: 305 EEPIYIVTELMKYGSLLEYLRGEDGV-LKIEQLVDVAAQVASGMSYLEQ---QNYIHRDL 360 Query: 395 KSSNVLLDE 421 + N+L+ E Sbjct: 361 AARNILVGE 369
>ANPRB_RAT (P16067) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 58.9 bits (141), Expect = 5e-09 Identities = 35/118 (29%), Positives = 60/118 (50%) Frame = +2 Query: 83 GQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTL 262 G +VA+K + ++ + + E++ + V ++ +G C+D +V EY P G+L Sbjct: 545 GNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSL 604 Query: 263 KESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 ++ L S + LDW R +I KG+A+LH H +KSSN ++D R K Sbjct: 605 QDILENDS-INLDWMFRYSLINDLVKGMAFLHNSIISS--HGSLKSSNCVVDSRFVLK 659
>ANPRB_MOUSE (Q6VVW5) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 58.9 bits (141), Expect = 5e-09 Identities = 35/118 (29%), Positives = 60/118 (50%) Frame = +2 Query: 83 GQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTL 262 G +VA+K + ++ + + E++ + V ++ +G C+D +V EY P G+L Sbjct: 545 GNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSL 604 Query: 263 KESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 ++ L S + LDW R +I KG+A+LH H +KSSN ++D R K Sbjct: 605 QDILENDS-INLDWMFRYSLINDLVKGMAFLHNSIISS--HGSLKSSNCVVDSRFVLK 659
>ANPRB_HUMAN (P20594) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 58.9 bits (141), Expect = 5e-09 Identities = 35/118 (29%), Positives = 60/118 (50%) Frame = +2 Query: 83 GQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTL 262 G +VA+K + ++ + + E++ + V ++ +G C+D +V EY P G+L Sbjct: 545 GNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSL 604 Query: 263 KESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 ++ L S + LDW R +I KG+A+LH H +KSSN ++D R K Sbjct: 605 QDILENDS-INLDWMFRYSLINDLVKGMAFLHNSIISS--HGSLKSSNCVVDSRFVLK 659
>ANPRB_BOVIN (P46197) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 58.9 bits (141), Expect = 5e-09 Identities = 35/118 (29%), Positives = 60/118 (50%) Frame = +2 Query: 83 GQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTL 262 G +VA+K + ++ + + E++ + V ++ +G C+D +V EY P G+L Sbjct: 545 GNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSL 604 Query: 263 KESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 ++ L S + LDW R +I KG+A+LH H +KSSN ++D R K Sbjct: 605 QDILENDS-INLDWMFRYSLINDLVKGMAFLHNSIIAS--HGSLKSSNCVVDSRFVLK 659
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 58.9 bits (141), Expect = 5e-09 Identities = 38/134 (28%), Positives = 71/134 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAVVSE 330 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G+ G L + + + A G+AY+ + VHRD+ Sbjct: 331 E-PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDL 386 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 387 RAANILVGENLVCK 400
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 58.9 bits (141), Expect = 5e-09 Identities = 38/134 (28%), Positives = 71/134 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAVVSE 330 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G+ G L + + + A G+AY+ + VHRD+ Sbjct: 331 E-PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDL 386 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 387 RAANILVGENLVCK 400
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 58.9 bits (141), Expect = 5e-09 Identities = 38/134 (28%), Positives = 71/134 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAVVSE 330 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G+ G L + + + A G+AY+ + VHRD+ Sbjct: 331 E-PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDL 386 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 387 RAANILVGENLVCK 400
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 58.9 bits (141), Expect = 5e-09 Identities = 42/144 (29%), Positives = 72/144 (50%), Gaps = 5/144 (3%) Frame = +2 Query: 8 TNNFSEGNDIGNGGFGKVYRGTLAT-GQLVAVKR----SQEGSLQGSLEFRTEIELLSRV 172 ++ F + +G G + VY+G T GQLVA+K S+EG+ ++ EI L+ + Sbjct: 5 SSQFQQLEKLGEGTYATVYKGRNRTNGQLVALKEINLDSEEGTPSTAIR---EISLMKEL 61 Query: 173 HHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAY 352 H+N+V+L + + LV+E++ K + LD K I KGI + Sbjct: 62 DHENIVTLYDVIHTENKLTLVFEFMDKDLKKYMEAHGNQGALDLKIVKSFIFQLLKGIMF 121 Query: 353 LHELADPPIVHRDIKSSNVLLDER 424 H D ++HRD+K N+L++ + Sbjct: 122 CH---DNRVLHRDLKPQNLLINNK 142
>MINK1_MOUSE (Q9JM52) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1308 Score = 58.9 bits (141), Expect = 5e-09 Identities = 42/142 (29%), Positives = 70/142 (49%), Gaps = 8/142 (5%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRTEIELLSRV-HHKNVVSLVGFC 208 +GNG +G+VY+G + TGQL A+K + + E + EI +L + HH+N+ + G Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIK-VMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAF 89 Query: 209 LDQG------EQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELAD 370 + + + LV E+ G++ + + G L + +G+A+LH Sbjct: 90 IKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHA--- 146 Query: 371 PPIVHRDIKSSNVLLDERLNAK 436 ++HRDIK NVLL E K Sbjct: 147 HKVIHRDIKGQNVLLTENAEVK 168
>M3K1_MOUSE (P53349) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1493 Score = 58.9 bits (141), Expect = 5e-09 Identities = 40/143 (27%), Positives = 74/143 (51%), Gaps = 11/143 (7%) Frame = +2 Query: 23 EGNDIGNGGFGKVYRGT-LATGQLVAVK-----RSQEGSLQGSLE-FRTEIELLSRVHHK 181 +G IG G F Y+ + TG L+AVK R+ + +E R EI ++ ++H Sbjct: 1226 KGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMGHLNHP 1285 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTG----KSGVRLDWKRRLRVILGTAKGIA 349 N++ ++G ++ L E++ G++ L+ K V +++ +L +G++ Sbjct: 1286 NIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQL------LRGLS 1339 Query: 350 YLHELADPPIVHRDIKSSNVLLD 418 YLHE I+HRD+K +N+L+D Sbjct: 1340 YLHE---NQIIHRDVKGANLLID 1359
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 58.9 bits (141), Expect = 5e-09 Identities = 42/135 (31%), Positives = 65/135 (48%) Frame = +2 Query: 32 DIGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCL 211 ++GNG FG V G VAVK +EG++ EF E + + ++ H +V G C Sbjct: 398 ELGNGQFGVVQLGQWKGQYDVAVKMIKEGAMSED-EFFQEAQTMMKLSHPKLVKFYGVCS 456 Query: 212 DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRD 391 + +V EYI NG L L G L+ + L + +G+A+L +HRD Sbjct: 457 KKYPIYIVTEYITNGCLLNYLK-SHGKGLESCQLLEMCYDVCEGMAFLE---SHQFIHRD 512 Query: 392 IKSSNVLLDERLNAK 436 + + N L+D L+ K Sbjct: 513 LAARNCLVDSDLSVK 527
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 58.9 bits (141), Expect = 5e-09 Identities = 38/134 (28%), Positives = 71/134 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAVVSE 330 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G+ G L + + + A G+AY+ + VHRD+ Sbjct: 331 E-PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDL 386 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 387 RAANILVGENLVCK 400
>ROS_HUMAN (P08922) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2347 Score = 58.9 bits (141), Expect = 5e-09 Identities = 42/140 (30%), Positives = 71/140 (50%), Gaps = 13/140 (9%) Frame = +2 Query: 35 IGNGGFGKVYRGT------LATGQL-VAVKRSQEGSL-QGSLEFRTEIELLSRVHHKNVV 190 +G+G FG+VY GT + +G++ VAVK ++GS Q +EF E L+S+ +H N++ Sbjct: 1951 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNIL 2010 Query: 191 SLVGFCLDQGEQMLVYEYIPNGTL-----KESLTGKSGVRLDWKRRLRVILGTAKGIAYL 355 +G CL Q ++ E + G L K + G L + + + +KG YL Sbjct: 2011 KQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYL 2070 Query: 356 HELADPPIVHRDIKSSNVLL 415 + +HRD+ + N L+ Sbjct: 2071 ERM---HFIHRDLAARNCLV 2087
>MET_RAT (P97523) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 58.9 bits (141), Expect = 5e-09 Identities = 46/140 (32%), Positives = 73/140 (52%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTL--ATGQLV--AVKR-SQEGSLQGSLEFRTEIELLSRVHHKNVVSLV 199 IG G FG VY GTL + G+ + AVK ++ ++ +F TE ++ H NV+SL+ Sbjct: 1085 IGRGHFGCVYHGTLLDSDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLL 1144 Query: 200 GFCL-DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G CL +G ++V Y+ +G L+ + ++ K + L AKG+ YL Sbjct: 1145 GICLRSEGSPLVVLPYMKHGDLRNFIRNETH-NPTVKDLIGFGLQVAKGMKYL---VSKK 1200 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N +LDE+ K Sbjct: 1201 FVHRDLAARNCMLDEKFTVK 1220
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 58.9 bits (141), Expect = 5e-09 Identities = 48/140 (34%), Positives = 71/140 (50%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKVYRGTLAT--GQLV--AVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSLV 199 IG G FG VY GTL G+ + AVK + G + +F TE ++ H NV+SL+ Sbjct: 1085 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 1144 Query: 200 GFCL-DQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G CL +G ++V Y+ +G L+ + ++ K + L AKG+ YL A Sbjct: 1145 GICLRSEGSPLVVLPYMKHGDLRNFIRNETH-NPTVKDLIGFGLQVAKGMKYL---ASKK 1200 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N +LDE K Sbjct: 1201 FVHRDLAARNCMLDENFTVK 1220
>JAK3_MOUSE (Q62137) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3)| (JAK-3) Length = 1299 Score = 58.9 bits (141), Expect = 5e-09 Identities = 45/140 (32%), Positives = 65/140 (46%), Gaps = 6/140 (4%) Frame = +2 Query: 35 IGNGGFGKV----YRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVG 202 +G G FG V Y TG LVAVK+ Q +F+ EI++L +H +V G Sbjct: 1038 LGKGNFGSVELCRYDPLDNTGPLVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRG 1097 Query: 203 FCLDQGEQML--VYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPP 376 G Q L V EY+P+G L++ L + L R L KG+ YL Sbjct: 1098 VSYGPGRQSLRLVMEYLPSGCLRDFLQ-RHRAALHTDRLLLFAWQICKGMEYLGARR--- 1153 Query: 377 IVHRDIKSSNVLLDERLNAK 436 VHRD+ + N+L++ + K Sbjct: 1154 CVHRDLAARNILVESEAHVK 1173 Score = 38.9 bits (89), Expect = 0.006 Identities = 38/139 (27%), Positives = 66/139 (47%), Gaps = 11/139 (7%) Frame = +2 Query: 32 DIGNGGFGKVYRG---------TLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKN 184 ++G+G F K++RG T + L+ V S+ + S F L+S+V + + Sbjct: 737 NLGHGSFTKIFRGRRREVVDGETHDSEVLLKVMDSRHRNCMES--FLEAASLMSQVSYPH 794 Query: 185 VVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSG-VRLDWKRRLRVILGTAKGIAY-LH 358 +V L G C+ G+ ++V E++ G + L + V WK L K +AY L+ Sbjct: 795 LVLLHGVCM-AGDSIMVQEFVYLGAIDMYLRKRGHLVSASWK------LQVTKQLAYALN 847 Query: 359 ELADPPIVHRDIKSSNVLL 415 L D + H ++ + VLL Sbjct: 848 YLEDKGLPHGNVSARKVLL 866
>CDC22_XENLA (P24033) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| (EC 2.7.11.23) (p34 protein kinase 2) Length = 302 Score = 58.9 bits (141), Expect = 5e-09 Identities = 42/142 (29%), Positives = 72/142 (50%), Gaps = 4/142 (2%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGT-LATGQLVAVKRSQ-EGSLQG--SLEFRTEIELLSRVHH 178 + +++ IG G +G VY+G ATGQ+VA+K+ + E +G S R EI LL + H Sbjct: 2 DEYTKIEKIGEGTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIR-EISLLKELQH 60 Query: 179 KNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLH 358 N+V L+ + L++E++ K + SG +D + +GI + H Sbjct: 61 PNIVCLLDVLMQDSRLYLIFEFLSMDVKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCH 120 Query: 359 ELADPPIVHRDIKSSNVLLDER 424 ++HRD+K N+L+D + Sbjct: 121 SRG---VLHRDLKPQNLLIDNK 139
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 58.9 bits (141), Expect = 5e-09 Identities = 38/134 (28%), Positives = 72/134 (53%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 280 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAVVSE 338 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G++G L + + + A G+AY+ + VHRD+ Sbjct: 339 E-PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERM---NYVHRDL 394 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 395 RAANILVGENLVCK 408
>SSK2_YEAST (P53599) MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of| sensor kinase 2) Length = 1579 Score = 58.5 bits (140), Expect = 7e-09 Identities = 46/143 (32%), Positives = 71/143 (49%), Gaps = 5/143 (3%) Frame = +2 Query: 5 ITNNFSEGNDIGNGGFGKVYRGT-LATGQLVAVKR---SQEGSLQGSLEF-RTEIELLSR 169 ++ + + N IG G FG+VY L G+++AVK S+Q + E+ +L Sbjct: 1262 VSMRWQKRNFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLEI 1321 Query: 170 VHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIA 349 ++H N+VS G + + + + EY G+L L + G D L +G+A Sbjct: 1322 LNHPNIVSYYGVEVHRDKVNIFMEYCEGGSLAALL--EHGRIEDEMVTQVYTLQLLEGLA 1379 Query: 350 YLHELADPPIVHRDIKSSNVLLD 418 YLHE IVHRD+K N+LLD Sbjct: 1380 YLHESG---IVHRDVKPENILLD 1399
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 58.5 bits (140), Expect = 7e-09 Identities = 41/136 (30%), Positives = 64/136 (47%), Gaps = 2/136 (1%) Frame = +2 Query: 35 IGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSL-EFRTEIELLSRVHHKNVVSLVGFC 208 IG GGF KV + TG++VA+K + +L L +TEI+ L + H+++ L Sbjct: 17 IGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHICQLYHVL 76 Query: 209 LDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHR 388 + + +V EY P G L + + + RL + V +AY+H HR Sbjct: 77 ETKNKIFMVLEYCPGGELFDYIISQD--RLSEEETRVVFRQILSAVAYVHSQG---YAHR 131 Query: 389 DIKSSNVLLDERLNAK 436 D+K N+L DE K Sbjct: 132 DLKPENLLFDENHKLK 147
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 58.5 bits (140), Expect = 7e-09 Identities = 38/134 (28%), Positives = 71/134 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 271 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAVVSE 329 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G+ G L + + + A G+AY+ + VHRD+ Sbjct: 330 E-PIYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMN---YVHRDL 385 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 386 RAANILVGENLVCK 399
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 58.5 bits (140), Expect = 7e-09 Identities = 38/134 (28%), Positives = 68/134 (50%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +GNG FG+V+ GT VAVK + G++ F E +++ ++ H +V L + Sbjct: 276 LGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPE-SFLEEAQIMKKLRHDKLVQLYA-VVS 333 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G L + + A G+AY+ + +HRD+ Sbjct: 334 EEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM---NYIHRDL 390 Query: 395 KSSNVLLDERLNAK 436 +S+N+L+ + L K Sbjct: 391 RSANILVGDNLVCK 404
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 58.5 bits (140), Expect = 7e-09 Identities = 42/155 (27%), Positives = 69/155 (44%), Gaps = 20/155 (12%) Frame = +2 Query: 32 DIGNGGFGKVYRGTL------ATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVS 193 ++G G FGKV+ LVAVK ++ +L +F+ E ELL+ + H+++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKVKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 194 LVGFCLDQGEQMLVYEYIPNGTLKESLTG--------------KSGVRLDWKRRLRVILG 331 G C D ++V+EY+ +G L + L ++ L + L + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 332 TAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 G+ Y LA VHRD+ + N L+ L K Sbjct: 663 ICSGMVY---LASQHFVHRDLATRNCLVGANLLVK 694
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 58.5 bits (140), Expect = 7e-09 Identities = 38/134 (28%), Positives = 71/134 (52%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 272 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVRLYAVVSE 330 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G+ G L + + + A G+AY+ + VHRD+ Sbjct: 331 E-PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDL 386 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 387 RAANILVGENLVCK 400
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 58.5 bits (140), Expect = 7e-09 Identities = 43/138 (31%), Positives = 65/138 (47%), Gaps = 4/138 (2%) Frame = +2 Query: 14 NFSEGNDIGNGGFGKVY----RGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHK 181 +F G +G G FGKVY R T L A+++ + +FR E+E+ HK Sbjct: 99 DFEIGKILGKGKFGKVYCVKHRETGLICALKAMEKKEIVQYTIQKQFRREVEIQGSFKHK 158 Query: 182 NVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHE 361 N+ L GF D+ L+ EY+ G L + L K+ L+ + A + Y+H Sbjct: 159 NLTQLYGFFYDEKRVYLLMEYVYYGELYKFL--KNNGPLNETLASYFVYQMANALDYMH- 215 Query: 362 LADPPIVHRDIKSSNVLL 415 I+HRDIK N+L+ Sbjct: 216 --SKNILHRDIKPENILI 231
>HUNK_MOUSE (O88866) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Length = 714 Score = 58.5 bits (140), Expect = 7e-09 Identities = 43/150 (28%), Positives = 64/150 (42%), Gaps = 5/150 (3%) Frame = +2 Query: 2 KITNNFSEGNDIGNGGFGKVYRGT-LATGQLVAVK----RSQEGSLQGSLEFRTEIELLS 166 ++ N +G G F KV G + TG+ VA+K + + + R E ++ Sbjct: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116 Query: 167 RVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGI 346 + H N+ L+ + LV E P G L + K RLD R I + Sbjct: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKK--RLDEAEARRYIRQLISAV 174 Query: 347 AYLHELADPPIVHRDIKSSNVLLDERLNAK 436 +LH +VHRD+K N+LLDE N K Sbjct: 175 EHLHRAG---VVHRDLKIENLLLDEDNNIK 201
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 58.5 bits (140), Expect = 7e-09 Identities = 38/134 (28%), Positives = 72/134 (53%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ GT VA+K + G++ F E +++ ++ H+ +V L + Sbjct: 275 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA-FLQEAQVMKKLRHEKLVQLYAVVSE 333 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G++G L + + + A G+AY+ + VHRD+ Sbjct: 334 E-PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVDRMN---YVHRDL 389 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 390 RAANILVGENLVCK 403
>CRK1_LEIME (Q06309) Cell division protein kinase 2 homolog CRK1 (EC 2.7.11.23)| Length = 301 Score = 58.2 bits (139), Expect = 9e-09 Identities = 41/147 (27%), Positives = 74/147 (50%), Gaps = 3/147 (2%) Frame = +2 Query: 5 ITNNFSEGNDIGNGGFGKVYRGT-LATGQLVAVKRSQEGSLQGSLEFRT--EIELLSRVH 175 +T+ + IG G +G VY+ +T VA+KR + S + + EI LL + Sbjct: 1 MTSRYERQEKIGEGTYGVVYKARDTSTAATVALKRIRLDSEEEGVPCTAIREISLLKELR 60 Query: 176 HKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYL 355 H+N+V L+ C + +V+EY+ + LK+ L ++G LD + +G+A+ Sbjct: 61 HENIVKLLDVCHSEHRLTIVFEYL-DLDLKKYLDRENG-NLDAATIQHFMRDLLRGVAFC 118 Query: 356 HELADPPIVHRDIKSSNVLLDERLNAK 436 H+ + ++HRD+K N+L+ K Sbjct: 119 HQRS---VLHRDLKPQNLLISREKELK 142
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 58.2 bits (139), Expect = 9e-09 Identities = 37/134 (27%), Positives = 69/134 (51%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +G G FG+V+ G VA+K ++GS+ S F E L+ + H +V L + Sbjct: 249 LGAGQFGEVWMGFYNGHTKVAIKNLKQGSMSPS-AFLAEANLMKNLQHPRLVRLYA-VVT 306 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + ++ EY+ G+L + L G++L + L + A+G+A++ +HRD+ Sbjct: 307 KEPIYIITEYMEKGSLVDFLKTSEGIKLSINKLLDMAAQIAEGMAFIEA---KNYIHRDL 363 Query: 395 KSSNVLLDERLNAK 436 +++N+L+ E L K Sbjct: 364 RAANILVSEALCCK 377
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 58.2 bits (139), Expect = 9e-09 Identities = 37/134 (27%), Positives = 68/134 (50%) Frame = +2 Query: 35 IGNGGFGKVYRGTLATGQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLD 214 +GNG FG+V+ GT VA+K + G++ F E +++ ++ H +V L + Sbjct: 276 LGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPE-SFLEEAQIMKKLKHDKLVQLYA-VVS 333 Query: 215 QGEQMLVYEYIPNGTLKESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDI 394 + +V EY+ G+L + L G L + + A+G+AY+ + +HRD+ Sbjct: 334 EEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVARGMAYIERM---NYIHRDL 390 Query: 395 KSSNVLLDERLNAK 436 +S+N+L+ L K Sbjct: 391 RSANILVGNGLICK 404
>ANPRB_ANGJA (P55202) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1050 Score = 58.2 bits (139), Expect = 9e-09 Identities = 35/118 (29%), Positives = 61/118 (51%) Frame = +2 Query: 83 GQLVAVKRSQEGSLQGSLEFRTEIELLSRVHHKNVVSLVGFCLDQGEQMLVYEYIPNGTL 262 G LVA+K + ++ + + E++ + V ++ +G C+D +V EY P G+L Sbjct: 549 GNLVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSL 608 Query: 263 KESLTGKSGVRLDWKRRLRVILGTAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 ++ L +S + LDW R +I KG+ +LH H ++KSSN ++D R K Sbjct: 609 QDILENES-INLDWMFRYSLINDIVKGMNFLHNSYIGS--HGNLKSSNCVVDSRFVLK 663
>PTK7_CHICK (Q91048) Tyrosine-protein kinase-like 7 precursor (Kinase-like| protein) Length = 1051 Score = 58.2 bits (139), Expect = 9e-09 Identities = 47/155 (30%), Positives = 72/155 (46%), Gaps = 13/155 (8%) Frame = +2 Query: 11 NNFSEGNDIGNGGFGKVYRGTL-----ATGQ-LVAVKRSQEGSLQGSLEFRTEIELLSRV 172 +N +G G FG+V+ A G+ LV VK Q Q L+FR E E+ ++ Sbjct: 775 SNLQTITTLGRGEFGEVFLAKAKGAEDAEGEALVLVKSLQTRDEQLQLDFRREAEMFGKL 834 Query: 173 HHKNVVSLVGFCLDQGEQMLVYEYIPNGTLKESL-TGKSGVR------LDWKRRLRVILG 331 +H NVV L+G C + +V EY+ G LK+ L KS L K ++ + Sbjct: 835 NHVNVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDESLKPQPLSTKHKVSLCTQ 894 Query: 332 TAKGIAYLHELADPPIVHRDIKSSNVLLDERLNAK 436 A G + L++ VHRD+ + N L+ + K Sbjct: 895 VALG---MEHLSNGRFVHRDLAARNCLVSAQRQVK 926 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 68,716,876 Number of Sequences: 219361 Number of extensions: 1540997 Number of successful extensions: 7721 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6249 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6563 length of database: 80,573,946 effective HSP length: 101 effective length of database: 58,418,485 effective search space used: 2570413340 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
