ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | basd19a21 |
|---|---|
| Clone Library Name | barley_pub |
>AFC3_ARATH (P51568) Serine/threonine-protein kinase AFC3 (EC 2.7.12.1)| Length = 400 Score = 177 bits (450), Expect(2) = 2e-82 Identities = 82/125 (65%), Positives = 102/125 (81%), Gaps = 5/125 (4%) Frame = +2 Query: 32 DGAGDPPPEREVVARGGA-----SPPWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFG 196 + +P +R V+ G+ SPP RDDDRDGHYVF L +NLT RYKILSKMGEGTFG Sbjct: 24 EAPAEPEAKRAVIKGHGSDGRILSPPLRDDDRDGHYVFSLRDNLTPRYKILSKMGEGTFG 83 Query: 197 RVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAENERYRSLCVQIQRWFDYRN 376 RVLECWDR+T+EYVAIK++RSI+KYRDAAMIEIDVL +L ++++ R+ CVQ++ WFDYRN Sbjct: 84 RVLECWDRDTKEYVAIKIIRSIKKYRDAAMIEIDVLQKLVKSDKGRTRCVQMKNWFDYRN 143 Query: 377 HICII 391 HICI+ Sbjct: 144 HICIV 148 Score = 148 bits (373), Expect(2) = 2e-82 Identities = 66/92 (71%), Positives = 81/92 (88%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 YMHEL+L+HTDLKPENILLVSSE +K+P +K+++ +E H +CLPKSSAIKLIDFGST D Sbjct: 186 YMHELQLVHTDLKPENILLVSSENVKLPDNKRSAANETHFRCLPKSSAIKLIDFGSTVCD 245 Query: 568 NQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 N+ H+SIV TRHYR+PE+ILGLGWS CD+WS Sbjct: 246 NRIHHSIVQTRHYRSPEVILGLGWSYQCDLWS 277
>AFC1_ARATH (P51566) Serine/threonine-protein kinase AFC1 (EC 2.7.12.1)| Length = 467 Score = 157 bits (397), Expect(2) = 1e-75 Identities = 72/102 (70%), Positives = 86/102 (84%) Frame = +2 Query: 86 SPPWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIR 265 SPPWR DD+DGHYVF +G+ LT RY+ILSKMGEGTFG+VLEC+D + +E VAIKV+RSI Sbjct: 91 SPPWRPDDKDGHYVFVVGDTLTPRYQILSKMGEGTFGQVLECFDNKNKEVVAIKVIRSIN 150 Query: 266 KYRDAAMIEIDVLNRLAENERYRSLCVQIQRWFDYRNHICII 391 KYR+AAMIEIDVL RL ++ S CVQI+ WFDYRNHICI+ Sbjct: 151 KYREAAMIEIDVLQRLTRHDVGGSRCVQIRNWFDYRNHICIV 192 Score = 145 bits (367), Expect(2) = 1e-75 Identities = 69/95 (72%), Positives = 82/95 (86%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSK---KNSQDEIHCKCLPKSSAIKLIDFGST 558 YMH+LRLIHTDLKPENILLVSSEYIK+P K + ++D + K LPKSSAIKLIDFGST Sbjct: 230 YMHDLRLIHTDLKPENILLVSSEYIKIPDYKFLSRPTKDGSYFKNLPKSSAIKLIDFGST 289 Query: 559 AFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 F++Q+HN IVSTRHYRAPE+ILG+GW+ PCD+WS Sbjct: 290 TFEHQDHNYIVSTRHYRAPEVILGVGWNYPCDLWS 324
>AFC2_ARATH (P51567) Serine/threonine-protein kinase AFC2 (EC 2.7.12.1)| Length = 427 Score = 166 bits (420), Expect(2) = 6e-75 Identities = 72/108 (66%), Positives = 95/108 (87%) Frame = +2 Query: 68 VARGGASPPWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIK 247 VAR G SPPWR+DD+DGHY+F+LG++LT RYKI SKMGEGTFG+VLECWDRE +E VA+K Sbjct: 69 VARNG-SPPWREDDKDGHYIFELGDDLTPRYKIYSKMGEGTFGQVLECWDRERKEMVAVK 127 Query: 248 VVRSIRKYRDAAMIEIDVLNRLAENERYRSLCVQIQRWFDYRNHICII 391 +VR ++KYR+AAMIEI++L +L ++++ + CVQI+ WFDYRNHICI+ Sbjct: 128 IVRGVKKYREAAMIEIEMLQQLGKHDKGGNRCVQIRNWFDYRNHICIV 175 Score = 135 bits (339), Expect(2) = 6e-75 Identities = 62/93 (66%), Positives = 78/93 (83%), Gaps = 1/93 (1%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNS-QDEIHCKCLPKSSAIKLIDFGSTAF 564 +MH+LR+IHTDLKPENILLVSS+Y+K+P K + Q ++ K +PKSSAIK+IDFGST + Sbjct: 213 FMHDLRMIHTDLKPENILLVSSDYVKIPEYKGSRLQRDVCYKRVPKSSAIKVIDFGSTTY 272 Query: 565 DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + Q+ IVSTRHYRAPE+ILGLGWS PCD+WS Sbjct: 273 ERQDQTYIVSTRHYRAPEVILGLGWSYPCDVWS 305
>DOA_DROME (P49762) Serine/threonine-protein kinase Doa (EC 2.7.12.1) (Protein| darkener of apricot) Length = 832 Score = 106 bits (265), Expect(2) = 5e-46 Identities = 50/92 (54%), Positives = 66/92 (71%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 ++H+ RL HTDLKPENIL V S+Y + K N + K++ ++LIDFGS FD Sbjct: 595 FLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVR-----RVKNTDVRLIDFGSATFD 649 Query: 568 NQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ H++IVSTRHYRAPE+IL LGWS PCD+WS Sbjct: 650 HEHHSTIVSTRHYRAPEVILELGWSQPCDVWS 681 Score = 98.2 bits (243), Expect(2) = 5e-46 Identities = 43/101 (42%), Positives = 70/101 (69%), Gaps = 1/101 (0%) Frame = +2 Query: 92 PWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKY 271 P DD DGH ++ G+ L RYKI++ +GEGTFGRV++ D E +A+K+++++ KY Sbjct: 457 PVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKY 516 Query: 272 RDAAMIEIDVLNRLAENERY-RSLCVQIQRWFDYRNHICII 391 R+AA +EI+ L ++A+ + + LCV++ WFDY H+CI+ Sbjct: 517 REAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIV 557
>LKH1_SCHPO (Q10156) Dual specificity protein kinase lkh1 (EC 2.7.12.1)| Length = 575 Score = 108 bits (270), Expect(2) = 8e-46 Identities = 50/92 (54%), Positives = 66/92 (71%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 ++H L L+HTDLKPEN+LLVS+ + +N ++ C I+LIDFGS F+ Sbjct: 363 FLHSLGLVHTDLKPENVLLVSNASRTIRLPYRNYSQKVLNSC-----EIRLIDFGSATFE 417 Query: 568 NQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ H+S+VSTRHYRAPEIILGLGWS PCD+WS Sbjct: 418 DEYHSSVVSTRHYRAPEIILGLGWSYPCDVWS 449 Score = 95.5 bits (236), Expect(2) = 8e-46 Identities = 44/104 (42%), Positives = 67/104 (64%), Gaps = 1/104 (0%) Frame = +2 Query: 83 ASPPWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI 262 A P DD DGHY RY ++ +G GTFG+V++C+D+ T + AIKV R+I Sbjct: 222 AFDPSTFDDDDGHYKVVPNSKFANRYTVVRLLGHGTFGKVIQCYDQSTGRHCAIKVTRAI 281 Query: 263 RKYRDAAMIEIDVLNRLAENE-RYRSLCVQIQRWFDYRNHICII 391 KYR+A++IE+ VL +A ++ + C+Q++ +FDYR HICI+ Sbjct: 282 PKYREASLIELRVLQTIAHSDPTNENKCIQLRDYFDYRKHICIV 325
>CLK3_RAT (Q63117) Dual specificity protein kinase CLK3 (EC 2.7.12.1)| (CDC-like kinase 3) Length = 490 Score = 102 bits (255), Expect(2) = 5e-44 Identities = 45/94 (47%), Positives = 69/94 (73%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++HE +L HTDLKPENIL V+SE+ + + K+ +++ K+++I++ DFGS Sbjct: 271 LRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKS-----VKNTSIRVADFGSAT 325 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 FD++ H +IV+TRHYR PE+IL LGW+ PCD+WS Sbjct: 326 FDHEHHTTIVATRHYRPPEVILELGWAQPCDVWS 359 Score = 95.1 bits (235), Expect(2) = 5e-44 Identities = 42/98 (42%), Positives = 70/98 (71%), Gaps = 2/98 (2%) Frame = +2 Query: 101 DDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDR-ETREYVAIKVVRSIRKYRD 277 +DD++GH V +G+ L RY+I+ +GEGTFG+V+EC D + VA+K++R++ KYR+ Sbjct: 137 EDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYRE 196 Query: 278 AAMIEIDVLNRLAENER-YRSLCVQIQRWFDYRNHICI 388 AA +EI+VL ++ E ++ + LCV + WF++ H+CI Sbjct: 197 AARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCI 234
>CLK3_MOUSE (O35492) Dual specificity protein kinase CLK3 (EC 2.7.12.1)| (CDC-like kinase 3) Length = 490 Score = 102 bits (255), Expect(2) = 5e-44 Identities = 45/94 (47%), Positives = 69/94 (73%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++HE +L HTDLKPENIL V+SE+ + + K+ +++ K+++I++ DFGS Sbjct: 271 LRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKS-----VKNTSIRVADFGSAT 325 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 FD++ H +IV+TRHYR PE+IL LGW+ PCD+WS Sbjct: 326 FDHEHHTTIVATRHYRPPEVILELGWAQPCDVWS 359 Score = 95.1 bits (235), Expect(2) = 5e-44 Identities = 42/98 (42%), Positives = 70/98 (71%), Gaps = 2/98 (2%) Frame = +2 Query: 101 DDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDR-ETREYVAIKVVRSIRKYRD 277 +DD++GH V +G+ L RY+I+ +GEGTFG+V+EC D + VA+K++R++ KYR+ Sbjct: 137 EDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYRE 196 Query: 278 AAMIEIDVLNRLAENER-YRSLCVQIQRWFDYRNHICI 388 AA +EI+VL ++ E ++ + LCV + WF++ H+CI Sbjct: 197 AARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCI 234
>CLK3_HUMAN (P49761) Dual specificity protein kinase CLK3 (EC 2.7.12.1)| (CDC-like kinase 3) Length = 490 Score = 102 bits (255), Expect(2) = 5e-44 Identities = 45/94 (47%), Positives = 69/94 (73%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++HE +L HTDLKPENIL V+SE+ + + K+ +++ K+++I++ DFGS Sbjct: 271 LRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKS-----VKNTSIRVADFGSAT 325 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 FD++ H +IV+TRHYR PE+IL LGW+ PCD+WS Sbjct: 326 FDHEHHTTIVATRHYRPPEVILELGWAQPCDVWS 359 Score = 95.1 bits (235), Expect(2) = 5e-44 Identities = 42/98 (42%), Positives = 70/98 (71%), Gaps = 2/98 (2%) Frame = +2 Query: 101 DDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDR-ETREYVAIKVVRSIRKYRD 277 +DD++GH V +G+ L RY+I+ +GEGTFG+V+EC D + VA+K++R++ KYR+ Sbjct: 137 EDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYRE 196 Query: 278 AAMIEIDVLNRLAENER-YRSLCVQIQRWFDYRNHICI 388 AA +EI+VL ++ E ++ + LCV + WF++ H+CI Sbjct: 197 AARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCI 234
>CLK4_MOUSE (O35493) Dual specificity protein kinase CLK4 (EC 2.7.12.1)| (CDC-like kinase 4) Length = 481 Score = 107 bits (267), Expect(2) = 2e-42 Identities = 49/94 (52%), Positives = 70/94 (74%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 ++++H +L HTDLKPENIL V S+Y+ V + K +DE K ++ IK++DFGS Sbjct: 274 INFLHHNKLTHTDLKPENILFVKSDYV-VKYNSKMKRDERTLK----NTDIKVVDFGSAT 328 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +D++ H+++VSTRHYRAPE+IL LGWS PCD+WS Sbjct: 329 YDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWS 362 Score = 85.5 bits (210), Expect(2) = 2e-42 Identities = 42/101 (41%), Positives = 64/101 (63%), Gaps = 4/101 (3%) Frame = +2 Query: 101 DDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETRE-YVAIKVVRSIRKYRD 277 +DD +GH + G+ L RY+I+ +GEG FG+V+EC D +VA+K+V+++ +YR+ Sbjct: 140 EDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGLHVAVKIVKNVGRYRE 199 Query: 278 AAMIEIDVLNRLAE---NERYRSLCVQIQRWFDYRNHICII 391 AA EI VL L N +R CVQ+ WFD+ H+CI+ Sbjct: 200 AARSEIQVLEHLNSTDPNSVFR--CVQMLEWFDHHGHVCIV 238
>CLK4_HUMAN (Q9HAZ1) Dual specificity protein kinase CLK4 (EC 2.7.12.1)| (CDC-like kinase 4) Length = 481 Score = 107 bits (267), Expect(2) = 2e-42 Identities = 49/94 (52%), Positives = 70/94 (74%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 ++++H +L HTDLKPENIL V S+Y+ V + K +DE K ++ IK++DFGS Sbjct: 274 INFLHHNKLTHTDLKPENILFVKSDYV-VKYNSKMKRDERTLK----NTDIKVVDFGSAT 328 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +D++ H+++VSTRHYRAPE+IL LGWS PCD+WS Sbjct: 329 YDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWS 362 Score = 85.5 bits (210), Expect(2) = 2e-42 Identities = 42/101 (41%), Positives = 64/101 (63%), Gaps = 4/101 (3%) Frame = +2 Query: 101 DDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDR-ETREYVAIKVVRSIRKYRD 277 +DD +GH + G+ L RY+I+ +GEG FG+V+EC D +VA+K+V+++ +YR+ Sbjct: 140 EDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYRE 199 Query: 278 AAMIEIDVLNRLAE---NERYRSLCVQIQRWFDYRNHICII 391 AA EI VL L N +R CVQ+ WFD+ H+CI+ Sbjct: 200 AARSEIQVLEHLNSTDPNSVFR--CVQMLEWFDHHGHVCIV 238
>CLK1_MOUSE (P22518) Dual specificity protein kinase CLK1 (EC 2.7.12.1)| (CDC-like kinase 1) (Protein kinase STY) Length = 483 Score = 103 bits (256), Expect(2) = 1e-41 Identities = 46/96 (47%), Positives = 68/96 (70%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKV--PSSKKNSQDEIHCKCLPKSSAIKLIDFGS 555 ++++H +L HTDLKPENIL V S+Y + P K++ + ++ IK++DFGS Sbjct: 275 VNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVN-------PDIKVVDFGS 327 Query: 556 TAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +D++ H+++VSTRHYRAPE+IL LGWS PCD+WS Sbjct: 328 ATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWS 363 Score = 87.0 bits (214), Expect(2) = 1e-41 Identities = 40/99 (40%), Positives = 65/99 (65%), Gaps = 2/99 (2%) Frame = +2 Query: 101 DDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRET-REYVAIKVVRSIRKYRD 277 +DD +GH + G+ L+ RY+I+ +GEG FG+V+EC D + VA+K+V+++ +Y + Sbjct: 141 EDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCE 200 Query: 278 AAMIEIDVLNRLAENERYRSL-CVQIQRWFDYRNHICII 391 AA EI VL L + + + CVQ+ WF++R HICI+ Sbjct: 201 AAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIV 239
>CLK1_HUMAN (P49759) Dual specificity protein kinase CLK1 (EC 2.7.12.1)| (CDC-like kinase 1) Length = 484 Score = 103 bits (256), Expect(2) = 5e-41 Identities = 47/96 (48%), Positives = 68/96 (70%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKV--PSSKKNSQDEIHCKCLPKSSAIKLIDFGS 555 ++++H +L HTDLKPENIL V S+Y + P K++ + I+ IK++DFGS Sbjct: 276 VNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLIN-------PDIKVVDFGS 328 Query: 556 TAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +D++ H+++VSTRHYRAPE+IL LGWS PCD+WS Sbjct: 329 ATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWS 364 Score = 84.7 bits (208), Expect(2) = 5e-41 Identities = 41/101 (40%), Positives = 65/101 (64%), Gaps = 4/101 (3%) Frame = +2 Query: 101 DDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRET-REYVAIKVVRSIRKYRD 277 +DD +GH + G+ L+ RY+I+ +GEG FG+V+EC D + +VA+K+V+++ +Y + Sbjct: 142 EDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCE 201 Query: 278 AAMIEIDV---LNRLAENERYRSLCVQIQRWFDYRNHICII 391 AA EI V LN N +R CVQ+ WF++ HICI+ Sbjct: 202 AARSEIQVLEHLNTTDPNSTFR--CVQMLEWFEHHGHICIV 240
>KNS1_YEAST (P32350) Dual specificity protein kinase KNS1 (EC 2.7.12.1)| Length = 737 Score = 101 bits (251), Expect(2) = 5e-39 Identities = 50/100 (50%), Positives = 67/100 (67%), Gaps = 8/100 (8%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYI--KVPS------SKKNSQDEIHCKCLPKSSAIKLI 543 ++H+L +IHTDLKPENIL+ +I K+P SK+ + + + K+ IK+I Sbjct: 430 FLHDLGIIHTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKII 489 Query: 544 DFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 DFGS F + H ++STRHYRAPEI+LGLGWS PCDIWS Sbjct: 490 DFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWS 529 Score = 80.1 bits (196), Expect(2) = 5e-39 Identities = 38/103 (36%), Positives = 66/103 (64%), Gaps = 4/103 (3%) Frame = +2 Query: 107 DRDGHYVFDLGENLTR--RYKILSKMGEGTFGRVLECWDRETR-EYVAIKVVRSIRKYRD 277 D+DGHYV+ + R+ + +G+GTFG+VL+C D + YVA+KV+R++ +YR+ Sbjct: 294 DKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYRE 353 Query: 278 AAMIEIDVLNRLAENE-RYRSLCVQIQRWFDYRNHICIICTNY 403 AA E+ +L + N+ + + C+ ++ FDY+NHIC++ Y Sbjct: 354 AAKTELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTDLY 396
>POM1_SCHPO (Q09690) Dual specificity protein kinase pom1 (EC 2.7.12.1)| Length = 1087 Score = 73.2 bits (178), Expect(2) = 1e-27 Identities = 33/96 (34%), Positives = 61/96 (63%), Gaps = 1/96 (1%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 DD G Y LG+++ RY+++ +G+G+FG+VL C D ET + VA+K++R+ +++ A Sbjct: 681 DDERGDYKVVLGDHIAYRYEVVDFLGKGSFGQVLRCIDYETGKLVALKIIRNKKRFHMQA 740 Query: 284 MIEIDVLNRLAENERYRSLC-VQIQRWFDYRNHICI 388 ++E +L ++ E + C VQ F +R+H+C+ Sbjct: 741 LVETKILQKIREWDPLDEYCMVQYTDHFYFRDHLCV 776 Score = 69.7 bits (169), Expect(2) = 1e-27 Identities = 35/91 (38%), Positives = 51/91 (56%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 ++E +IH DLKPENILL C P S +K+IDFGS+ F+ Sbjct: 816 LNEKHVIHCDLKPENILL----------------------CHPFKSQVKVIDFGSSCFEG 853 Query: 571 QEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + + +R YR+PE+ILG+G+ P D+WS Sbjct: 854 ECVYTYIQSRFYRSPEVILGMGYGTPIDVWS 884
>MNB_DROME (P49657) Serine/threonine-protein kinase minibrain (EC 2.7.12.1)| Length = 908 Score = 71.2 bits (173), Expect(2) = 4e-26 Identities = 38/112 (33%), Positives = 71/112 (63%), Gaps = 6/112 (5%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 DD + Y+ GE RY+I S +G+G+FG+V++ +D E + +VAIK++++ + + + A Sbjct: 146 DDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQA 205 Query: 284 MIEIDVLNRL----AENERYRSLCVQIQRWFDYRNHICII--CTNYALFTLI 421 IE+ +L + AEN+ Y V+++R F +RNH+C++ +Y L+ L+ Sbjct: 206 QIEVKLLEMMNRADAENKYY---IVKLKRHFMWRNHLCLVFELLSYNLYDLL 254 Score = 66.6 bits (161), Expect(2) = 4e-26 Identities = 36/89 (40%), Positives = 48/89 (53%) Frame = +1 Query: 397 ELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDNQE 576 EL +IH DLKPENILL C PK SAIK++DFGS+ Q Sbjct: 285 ELNIIHCDLKPENILL----------------------CNPKRSAIKIVDFGSSCQLGQR 322 Query: 577 HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + +R YR+PE++LG+ + L D+WS Sbjct: 323 IYHYIQSRFYRSPEVLLGIQYDLAIDMWS 351
>DYR1B_HUMAN (Q9Y463) Dual specificity tyrosine-phosphorylation-regulated kinase| 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase) Length = 629 Score = 72.0 bits (175), Expect(2) = 6e-26 Identities = 35/109 (32%), Positives = 70/109 (64%), Gaps = 3/109 (2%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 DD + Y+ GE RY+I S +G+G+FG+V++ +D +T+E VAIK++++ + + + A Sbjct: 93 DDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQA 152 Query: 284 MIEIDVLNRLAENE-RYRSLCVQIQRWFDYRNHICII--CTNYALFTLI 421 IE+ +L + +++ + V ++R F +RNH+C++ +Y L+ L+ Sbjct: 153 QIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLL 201 Score = 65.5 bits (158), Expect(2) = 6e-26 Identities = 36/89 (40%), Positives = 47/89 (52%) Frame = +1 Query: 397 ELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDNQE 576 EL +IH DLKPENILL C PK SAIK++DFGS+ Q Sbjct: 232 ELSIIHCDLKPENILL----------------------CNPKRSAIKIVDFGSSCQLGQR 269 Query: 577 HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + +R YR+PE++LG + L D+WS Sbjct: 270 IYQYIQSRFYRSPEVLLGTPYDLAIDMWS 298
>DYR1B_MOUSE (Q9Z188) Dual specificity tyrosine-phosphorylation-regulated kinase| 1B (EC 2.7.12.1) Length = 589 Score = 72.0 bits (175), Expect(2) = 6e-26 Identities = 35/109 (32%), Positives = 70/109 (64%), Gaps = 3/109 (2%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 DD + Y+ GE RY+I S +G+G+FG+V++ +D +T+E VAIK++++ + + + A Sbjct: 93 DDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQA 152 Query: 284 MIEIDVLNRLAENE-RYRSLCVQIQRWFDYRNHICII--CTNYALFTLI 421 IE+ +L + +++ + V ++R F +RNH+C++ +Y L+ L+ Sbjct: 153 QIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLL 201 Score = 65.5 bits (158), Expect(2) = 6e-26 Identities = 36/89 (40%), Positives = 47/89 (52%) Frame = +1 Query: 397 ELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDNQE 576 EL +IH DLKPENILL C PK SAIK++DFGS+ Q Sbjct: 232 ELSIIHCDLKPENILL----------------------CNPKRSAIKIVDFGSSCQLGQR 269 Query: 577 HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + +R YR+PE++LG + L D+WS Sbjct: 270 IYQYIQSRFYRSPEVLLGTPYDLAIDMWS 298
>DYRK3_HUMAN (O43781) Dual specificity tyrosine-phosphorylation-regulated kinase| 3 (EC 2.7.12.1) Length = 588 Score = 71.2 bits (173), Expect(2) = 6e-26 Identities = 33/96 (34%), Positives = 61/96 (63%), Gaps = 1/96 (1%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 DD DG Y+ ++L RY++L +G+G+FG+V +D + R+YVA+K+VR+ +++ A Sbjct: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQA 250 Query: 284 MIEIDVLNRLAENERYRSL-CVQIQRWFDYRNHICI 388 EI +L L + ++ S+ + + F +RNH+C+ Sbjct: 251 AEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCM 286 Score = 66.2 bits (160), Expect(2) = 6e-26 Identities = 38/91 (41%), Positives = 53/91 (58%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 +H+ ++IH DLKPENILL K + + S+ K+IDFGS+ F+ Sbjct: 326 LHKNKIIHCDLKPENILL-----------KHHGR-----------SSTKVIDFGSSCFEY 363 Query: 571 QEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 Q+ + + +R YRAPEIILG +S P DIWS Sbjct: 364 QKLYTYIQSRFYRAPEIILGSRYSTPIDIWS 394
>DYR1A_RAT (Q63470) Dual specificity tyrosine-phosphorylation-regulated kinase| 1A (EC 2.7.12.2) (Protein kinase minibrain homolog) (MNBH) (RP86) (Dual specificity YAK1-related kinase) Length = 763 Score = 70.1 bits (170), Expect(2) = 9e-26 Identities = 35/109 (32%), Positives = 70/109 (64%), Gaps = 3/109 (2%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 DD + Y+ GE RY+I S +G+G+FG+V++ +DR +E+VAIK++++ + + + A Sbjct: 141 DDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQA 200 Query: 284 MIEIDVLNRLAENE-RYRSLCVQIQRWFDYRNHICII--CTNYALFTLI 421 IE+ +L + +++ + V ++R F +RNH+C++ +Y L+ L+ Sbjct: 201 QIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLL 249 Score = 66.6 bits (161), Expect(2) = 9e-26 Identities = 36/89 (40%), Positives = 48/89 (53%) Frame = +1 Query: 397 ELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDNQE 576 EL +IH DLKPENILL C PK SAIK++DFGS+ Q Sbjct: 280 ELSIIHCDLKPENILL----------------------CNPKRSAIKIVDFGSSCQLGQR 317 Query: 577 HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + +R YR+PE++LG+ + L D+WS Sbjct: 318 IYQYIQSRFYRSPEVLLGMPYDLAIDMWS 346
>DYR1A_MOUSE (Q61214) Dual specificity tyrosine-phosphorylation-regulated kinase| 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase) Length = 763 Score = 70.1 bits (170), Expect(2) = 9e-26 Identities = 35/109 (32%), Positives = 70/109 (64%), Gaps = 3/109 (2%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 DD + Y+ GE RY+I S +G+G+FG+V++ +DR +E+VAIK++++ + + + A Sbjct: 141 DDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQA 200 Query: 284 MIEIDVLNRLAENE-RYRSLCVQIQRWFDYRNHICII--CTNYALFTLI 421 IE+ +L + +++ + V ++R F +RNH+C++ +Y L+ L+ Sbjct: 201 QIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLL 249 Score = 66.6 bits (161), Expect(2) = 9e-26 Identities = 36/89 (40%), Positives = 48/89 (53%) Frame = +1 Query: 397 ELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDNQE 576 EL +IH DLKPENILL C PK SAIK++DFGS+ Q Sbjct: 280 ELSIIHCDLKPENILL----------------------CNPKRSAIKIVDFGSSCQLGQR 317 Query: 577 HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + +R YR+PE++LG+ + L D+WS Sbjct: 318 IYQYIQSRFYRSPEVLLGMPYDLAIDMWS 346
>DYR1A_HUMAN (Q13627) Dual specificity tyrosine-phosphorylation-regulated kinase| 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase) Length = 763 Score = 70.1 bits (170), Expect(2) = 9e-26 Identities = 35/109 (32%), Positives = 70/109 (64%), Gaps = 3/109 (2%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 DD + Y+ GE RY+I S +G+G+FG+V++ +DR +E+VAIK++++ + + + A Sbjct: 141 DDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQA 200 Query: 284 MIEIDVLNRLAENE-RYRSLCVQIQRWFDYRNHICII--CTNYALFTLI 421 IE+ +L + +++ + V ++R F +RNH+C++ +Y L+ L+ Sbjct: 201 QIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLL 249 Score = 66.6 bits (161), Expect(2) = 9e-26 Identities = 36/89 (40%), Positives = 48/89 (53%) Frame = +1 Query: 397 ELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDNQE 576 EL +IH DLKPENILL C PK SAIK++DFGS+ Q Sbjct: 280 ELSIIHCDLKPENILL----------------------CNPKRSAIKIVDFGSSCQLGQR 317 Query: 577 HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + +R YR+PE++LG+ + L D+WS Sbjct: 318 IYQYIQSRFYRSPEVLLGMPYDLAIDMWS 346
>CLK2_MOUSE (O35491) Dual specificity protein kinase CLK2 (EC 2.7.12.1)| (CDC-like kinase 2) Length = 499 Score = 108 bits (269), Expect = 2e-23 Identities = 49/93 (52%), Positives = 69/93 (74%), Gaps = 1/93 (1%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEY-IKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAF 564 ++H+ +L HTDLKPENIL V+S+Y + KK + + KS+A++++DFGS F Sbjct: 279 FLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSV------KSTAVRVVDFGSATF 332 Query: 565 DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 D++ H++IVSTRHYRAPE+IL LGWS PCD+WS Sbjct: 333 DHEHHSTIVSTRHYRAPEVILELGWSQPCDVWS 365 Score = 96.3 bits (238), Expect = 7e-20 Identities = 54/144 (37%), Positives = 90/144 (62%), Gaps = 3/144 (2%) Frame = +2 Query: 101 DDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWD-RETREYVAIKVVRSIRKYRD 277 +DD +GH ++ +G+ L RY+I+S +GEGT GRV++C D R VA+K+++++ KY++ Sbjct: 143 EDDAEGHLIYHVGDWLQERYEIVSTLGEGTSGRVVQCVDHRRGGTRVALKIIKNVEKYKE 202 Query: 278 AAMIEIDVLNRLAENE-RYRSLCVQIQRWFDYRNHICIICTNYALFTLI*SQKTYSLYLP 454 AA +EI+VL ++ E + ++LCVQ+ WFDY H+CI ++ L L T+ Sbjct: 203 AARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCI---SFELLGL----STFDFLKD 255 Query: 455 NI*RFQVPRRIHKMRYTA-SACQS 523 N +P IH++R+ A CQ+ Sbjct: 256 N---NYLPYPIHQVRHMAFQLCQA 276
>CLK2_HUMAN (P49760) Dual specificity protein kinase CLK2 (EC 2.7.12.1)| (CDC-like kinase 2) Length = 499 Score = 108 bits (269), Expect = 2e-23 Identities = 49/93 (52%), Positives = 69/93 (74%), Gaps = 1/93 (1%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEY-IKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAF 564 ++H+ +L HTDLKPENIL V+S+Y + KK + + KS+A++++DFGS F Sbjct: 280 FLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSV------KSTAVRVVDFGSATF 333 Query: 565 DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 D++ H++IVSTRHYRAPE+IL LGWS PCD+WS Sbjct: 334 DHEHHSTIVSTRHYRAPEVILELGWSQPCDVWS 366 Score = 99.4 bits (246), Expect = 9e-21 Identities = 55/144 (38%), Positives = 91/144 (63%), Gaps = 3/144 (2%) Frame = +2 Query: 101 DDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWD-RETREYVAIKVVRSIRKYRD 277 +DD +GH ++ +G+ L RY+I+S +GEGTFGRV++C D R VA+K+++++ KY++ Sbjct: 144 EDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKE 203 Query: 278 AAMIEIDVLNRLAENE-RYRSLCVQIQRWFDYRNHICIICTNYALFTLI*SQKTYSLYLP 454 AA +EI+VL ++ E + ++LCVQ+ WFDY H+CI ++ L L T+ Sbjct: 204 AARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCI---SFELLGL----STFDFLKD 256 Query: 455 NI*RFQVPRRIHKMRYTA-SACQS 523 N +P IH++R+ A CQ+ Sbjct: 257 N---NYLPYPIHQVRHMAFQLCQA 277
>DYRK2_DROME (Q9V3D5) Dual specificity tyrosine-phosphorylation-regulated kinase| 2 (EC 2.7.12.1) (dDyrk2) (Protein smell impaired at 35A) Length = 722 Score = 64.7 bits (156), Expect(2) = 9e-22 Identities = 30/96 (31%), Positives = 62/96 (64%), Gaps = 1/96 (1%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 DD +G+Y +++ RY+IL +G+G+FG+V+ D +T +VAIK++R+ +++ + A Sbjct: 180 DDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQA 239 Query: 284 MIEIDVLNRLAENERYRS-LCVQIQRWFDYRNHICI 388 ++E+++L+ L E + S + + + +R H+CI Sbjct: 240 VVELNILDELREKDADGSHNVIHMLDYTYFRKHLCI 275 Score = 58.5 bits (140), Expect(2) = 9e-22 Identities = 32/94 (34%), Positives = 51/94 (54%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + +++ +IH DLKPENILL SS+IK+IDFGS+ Sbjct: 312 LRLLYKENIIHCDLKPENILLKQR----------------------GSSSIKVIDFGSSC 349 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + +++ + + +R YR+PE+ILGL + D+WS Sbjct: 350 YVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWS 383
>HIPK1_MOUSE (O88904) Homeodomain-interacting protein kinase 1 (EC 2.7.11.1)| (Protein kinase Myak) (Nuclear body-associated kinase 2) Length = 1210 Score = 69.3 bits (168), Expect(2) = 3e-21 Identities = 29/83 (34%), Positives = 50/83 (60%) Frame = +2 Query: 143 NLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAEN 322 ++T Y++L +G GTFG+V +CW R T+E VAIK++++ Y IE+ +L+RL+ Sbjct: 185 SMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSE 244 Query: 323 ERYRSLCVQIQRWFDYRNHICII 391 V+ F ++NH C++ Sbjct: 245 NADEYNFVRSYECFQHKNHTCLV 267 Score = 52.0 bits (123), Expect(2) = 3e-21 Identities = 33/92 (35%), Positives = 49/92 (53%), Gaps = 1/92 (1%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + L LIH DLKPENI+LV + + +K+IDFGS + + Sbjct: 306 LKSLGLIHADLKPENIMLVDP--------------------VRQPYRVKVIDFGSASHVS 345 Query: 571 QEH-NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + ++ + +R+YRAPEIILGL + D+WS Sbjct: 346 KAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 377
>HIPK1_HUMAN (Q86Z02) Homeodomain-interacting protein kinase 1 (EC 2.7.11.1)| Length = 1210 Score = 69.3 bits (168), Expect(2) = 3e-21 Identities = 29/83 (34%), Positives = 50/83 (60%) Frame = +2 Query: 143 NLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAEN 322 ++T Y++L +G GTFG+V +CW R T+E VAIK++++ Y IE+ +L+RL+ Sbjct: 185 SMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSE 244 Query: 323 ERYRSLCVQIQRWFDYRNHICII 391 V+ F ++NH C++ Sbjct: 245 NADEYNFVRSYECFQHKNHTCLV 267 Score = 52.0 bits (123), Expect(2) = 3e-21 Identities = 33/92 (35%), Positives = 49/92 (53%), Gaps = 1/92 (1%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + L LIH DLKPENI+LV + + +K+IDFGS + + Sbjct: 306 LKSLGLIHADLKPENIMLVDP--------------------VRQPYRVKVIDFGSASHVS 345 Query: 571 QEH-NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + ++ + +R+YRAPEIILGL + D+WS Sbjct: 346 KAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 377
>HIPK2_HUMAN (Q9H2X6) Homeodomain-interacting protein kinase 2 (EC 2.7.11.1)| (hHIPk2) Length = 1198 Score = 66.6 bits (161), Expect(2) = 2e-20 Identities = 29/83 (34%), Positives = 49/83 (59%) Frame = +2 Query: 143 NLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAEN 322 ++T Y++L +G GTFG+V++CW R T E VAIK++++ Y IE+ +L RL+ Sbjct: 194 SMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 253 Query: 323 ERYRSLCVQIQRWFDYRNHICII 391 V+ F ++NH C++ Sbjct: 254 SADDYNFVRAYECFQHKNHTCLV 276 Score = 52.4 bits (124), Expect(2) = 2e-20 Identities = 35/92 (38%), Positives = 50/92 (54%), Gaps = 1/92 (1%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + L LIH DLKPENI+LV PS + +K+IDFGS + + Sbjct: 315 LKSLGLIHADLKPENIMLVD------PSRQPYR--------------VKVIDFGSASHVS 354 Query: 571 QEH-NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + ++ + +R+YRAPEIILGL + D+WS Sbjct: 355 KAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 386
>HIPK2_MOUSE (Q9QZR5) Homeodomain-interacting protein kinase 2 (EC 2.7.11.1)| (Nuclear body-associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase) Length = 1196 Score = 66.6 bits (161), Expect(2) = 2e-20 Identities = 29/83 (34%), Positives = 49/83 (59%) Frame = +2 Query: 143 NLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAEN 322 ++T Y++L +G GTFG+V++CW R T E VAIK++++ Y IE+ +L RL+ Sbjct: 194 SMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 253 Query: 323 ERYRSLCVQIQRWFDYRNHICII 391 V+ F ++NH C++ Sbjct: 254 SADDYNFVRAYECFQHKNHTCLV 276 Score = 52.4 bits (124), Expect(2) = 2e-20 Identities = 35/92 (38%), Positives = 50/92 (54%), Gaps = 1/92 (1%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + L LIH DLKPENI+LV PS + +K+IDFGS + + Sbjct: 315 LKSLGLIHADLKPENIMLVD------PSRQPYR--------------VKVIDFGSASHVS 354 Query: 571 QEH-NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + ++ + +R+YRAPEIILGL + D+WS Sbjct: 355 KAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 386
>HIPK2_MESAU (Q9WUM7) Homeodomain-interacting protein kinase 2 (EC 2.7.11.1)| (Mx-interacting protein kinase) (PKM) Length = 1168 Score = 66.6 bits (161), Expect(2) = 2e-20 Identities = 29/83 (34%), Positives = 49/83 (59%) Frame = +2 Query: 143 NLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAEN 322 ++T Y++L +G GTFG+V++CW R T E VAIK++++ Y IE+ +L RL+ Sbjct: 194 SMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 253 Query: 323 ERYRSLCVQIQRWFDYRNHICII 391 V+ F ++NH C++ Sbjct: 254 SADDYNFVRAYECFQHKNHTCLV 276 Score = 52.4 bits (124), Expect(2) = 2e-20 Identities = 35/92 (38%), Positives = 50/92 (54%), Gaps = 1/92 (1%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + L LIH DLKPENI+LV PS + +K+IDFGS + + Sbjct: 315 LKSLGLIHADLKPENIMLVD------PSRQPYR--------------VKVIDFGSASHVS 354 Query: 571 QEH-NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + ++ + +R+YRAPEIILGL + D+WS Sbjct: 355 KAVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 386
>YAK1_YEAST (P14680) Dual specificity protein kinase YAK1 (EC 2.7.12.1)| Length = 807 Score = 63.2 bits (152), Expect(2) = 2e-20 Identities = 35/91 (38%), Positives = 48/91 (52%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + E +LIH DLKPENILL C P +K+IDFGS+ + Sbjct: 487 LKESKLIHCDLKPENILL----------------------CAPDKPELKIIDFGSSCEEA 524 Query: 571 QEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + + +R YRAPEIILG+ +S D+WS Sbjct: 525 RTVYTYIQSRFYRAPEIILGIPYSTSIDMWS 555 Score = 55.5 bits (132), Expect(2) = 2e-20 Identities = 30/93 (32%), Positives = 57/93 (61%), Gaps = 3/93 (3%) Frame = +2 Query: 122 YVFD-LGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEID 298 YV D LG R+Y +L +G+GTFG+V++C + T+E +A+KVV+S +Y ++ E Sbjct: 356 YVNDVLGVEQNRKYLVLDILGQGTFGQVVKCQNLLTKEILAVKVVKSRTEYLTQSITEAK 415 Query: 299 VLNRLAE--NERYRSLCVQIQRWFDYRNHICII 391 +L L + + + +++ F ++NH+C++ Sbjct: 416 ILELLNQKIDPTNKHHFLRMYDSFVHKNHLCLV 448
>HIPK3_HUMAN (Q9H422) Homeodomain-interacting protein kinase 3 (EC 2.7.11.1)| (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK) Length = 1215 Score = 66.2 bits (160), Expect(2) = 3e-20 Identities = 29/83 (34%), Positives = 48/83 (57%) Frame = +2 Query: 143 NLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAEN 322 ++ Y++L +G GTFG+V++CW R T E VAIK++++ Y IE+ +L RL+ Sbjct: 192 SMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 251 Query: 323 ERYRSLCVQIQRWFDYRNHICII 391 V+ F +RNH C++ Sbjct: 252 NADEYNFVRAYECFQHRNHTCLV 274 Score = 52.0 bits (123), Expect(2) = 3e-20 Identities = 33/92 (35%), Positives = 49/92 (53%), Gaps = 1/92 (1%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + L LIH DLKPENI+LV + + +K+IDFGS + + Sbjct: 313 LKSLGLIHADLKPENIMLVDP--------------------VRQPYRVKVIDFGSASHVS 352 Query: 571 QEH-NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + ++ + +R+YRAPEIILGL + D+WS Sbjct: 353 KTVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 384
>HIPK3_MOUSE (Q9ERH7) Homeodomain-interacting protein kinase 3 (EC 2.7.11.1)| (Fas-interacting serine/threonine-protein kinase) (FIST) (Nuclear body-associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK) Length = 1192 Score = 66.2 bits (160), Expect(2) = 3e-20 Identities = 29/83 (34%), Positives = 48/83 (57%) Frame = +2 Query: 143 NLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAEN 322 ++ Y++L +G GTFG+V++CW R T E VAIK++++ Y IE+ +L RL+ Sbjct: 192 SMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 251 Query: 323 ERYRSLCVQIQRWFDYRNHICII 391 V+ F +RNH C++ Sbjct: 252 NADEYNFVRAYECFQHRNHTCLV 274 Score = 52.0 bits (123), Expect(2) = 3e-20 Identities = 33/92 (35%), Positives = 49/92 (53%), Gaps = 1/92 (1%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + L LIH DLKPENI+LV + + +K+IDFGS + + Sbjct: 313 LKSLGLIHADLKPENIMLVDP--------------------VRQPYRVKVIDFGSASHVS 352 Query: 571 QEH-NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + ++ + +R+YRAPEIILGL + D+WS Sbjct: 353 KTVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 384
>HIPK3_RAT (O88850) Homeodomain-interacting protein kinase 3 (EC 2.7.11.1)| (Androgen receptor-interacting nuclear protein kinase) (ANPK) Length = 1191 Score = 65.9 bits (159), Expect(2) = 4e-20 Identities = 29/78 (37%), Positives = 46/78 (58%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAENERYRS 337 Y++L +G GTFG+V++CW R T E VAIK++++ Y IE+ +L RL+ Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEY 256 Query: 338 LCVQIQRWFDYRNHICII 391 V+ F +RNH C++ Sbjct: 257 NFVRAYECFQHRNHTCLV 274 Score = 52.0 bits (123), Expect(2) = 4e-20 Identities = 33/92 (35%), Positives = 49/92 (53%), Gaps = 1/92 (1%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + L LIH DLKPENI+LV + + +K+IDFGS + + Sbjct: 313 LKSLGLIHADLKPENIMLVDP--------------------VRQPYRVKVIDFGSASHVS 352 Query: 571 QEH-NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + ++ + +R+YRAPEIILGL + D+WS Sbjct: 353 KTVCSTYLQSRYYRAPEIILGLPFCEAIDMWS 384
>KKB3_SCHPO (Q9P6P3) Putative serine/threonine-protein kinase C823.03 (EC| 2.7.11.1) Length = 534 Score = 59.7 bits (143), Expect(2) = 4e-20 Identities = 32/95 (33%), Positives = 58/95 (61%), Gaps = 5/95 (5%) Frame = +2 Query: 122 YVFDL-GENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEID 298 YV DL G + R+Y IL +G GTFG+V C D +T++ VAIKV+++ + + ++E+ Sbjct: 117 YVNDLLGTDEGRKYLILDTLGHGTFGQVARCQDLKTQQIVAIKVIKNKPAFYNQCVMEVS 176 Query: 299 VLNRLAENERY----RSLCVQIQRWFDYRNHICII 391 +L L N +Y + +++ F ++NH+C++ Sbjct: 177 ILELL--NNKYDPEDKRHLIRLYDQFMHKNHLCLV 209 Score = 58.2 bits (139), Expect(2) = 4e-20 Identities = 34/91 (37%), Positives = 48/91 (52%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + + R+IH DLKPENILL QD S +K+IDFGS + Sbjct: 248 LKQARIIHCDLKPENILL---------------QD-------LSSPIVKVIDFGSACHER 285 Query: 571 QEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 Q + + +R YR+PE+ILGL ++ D+WS Sbjct: 286 QTVYTYIQSRFYRSPEVILGLHYNCGIDMWS 316
>PRP4_SCHPO (Q07538) Serine/threonine-protein kinase prp4 (EC 2.7.11.1)| Length = 477 Score = 58.9 bits (141), Expect(2) = 2e-16 Identities = 30/97 (30%), Positives = 52/97 (53%), Gaps = 1/97 (1%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 DD +G+Y L E L RY + S +G+G F V+ DR + AIK++R+ Sbjct: 141 DDIEGYYKVVLMEELDSRYIVQSNLGKGMFSTVVSALDRNRNQTFAIKIIRNNEVMYKEG 200 Query: 284 MIEIDVLNRL-AENERYRSLCVQIQRWFDYRNHICII 391 + E+ +L RL A + + + +R F ++NH+C++ Sbjct: 201 LKEVSILERLQAADREGKQHIIHYERHFMHKNHLCMV 237 Score = 46.6 bits (109), Expect(2) = 2e-16 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 2/93 (2%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST--AF 564 + + +IH+D+KP+N+L+ + K+N +K+ D GS A Sbjct: 277 LKQCNVIHSDIKPDNMLV---------NEKRN--------------ILKICDLGSASDAS 313 Query: 565 DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +N+ +VS R YRAPEIILG +S P D WS Sbjct: 314 ENEITPYLVS-RFYRAPEIILGFPYSCPIDTWS 345
>KAB7_SCHPO (Q09815) Probable serine/threonine-protein kinase C16C9.07 (EC| 2.7.12.1) Length = 836 Score = 74.3 bits (181), Expect = 3e-13 Identities = 34/97 (35%), Positives = 63/97 (64%), Gaps = 1/97 (1%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 DD +G Y G++L RY+I+ +G+G+FG+VL+C D + + VAIKV+++ +K+ Sbjct: 500 DDDNGDYKAIQGDHLLYRYEIIDTVGKGSFGQVLKCIDHKRGQVVAIKVIKNRQKFHGQT 559 Query: 284 MIEIDVLNRLAE-NERYRSLCVQIQRWFDYRNHICII 391 ++E+ +L RL E + ++ ++ FD+R H+CI+ Sbjct: 560 LVEVGILKRLCEADPADKNNVIRYLSHFDFRGHLCIV 596 Score = 62.0 bits (149), Expect = 2e-09 Identities = 36/86 (41%), Positives = 46/86 (53%) Frame = +1 Query: 406 LIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDNQEHNS 585 +IH DLKPEN+LL P + IKLIDFGS+ F N++ + Sbjct: 640 IIHCDLKPENLLLSH----------------------PLKARIKLIDFGSSCFYNEKVYT 677 Query: 586 IVSTRHYRAPEIILGLGWSLPCDIWS 663 + +R YRAPEIILGL + DIWS Sbjct: 678 YLQSRFYRAPEIILGLEYGKEIDIWS 703
>DYRK4_HUMAN (Q9NR20) Dual specificity tyrosine-phosphorylation-regulated kinase| 4 (EC 2.7.12.1) Length = 520 Score = 72.4 bits (176), Expect = 1e-12 Identities = 31/96 (32%), Positives = 62/96 (64%), Gaps = 1/96 (1%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 DD G Y+ L +++ RY++L +G+G+FG+V +C D + E VA+K++R+ +++ A Sbjct: 86 DDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQA 145 Query: 284 MIEIDVLNRLAENERYRSL-CVQIQRWFDYRNHICI 388 ++E+ +L L + ++ + V ++ +F +RNH CI Sbjct: 146 LMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCI 181 Score = 56.2 bits (134), Expect = 8e-08 Identities = 28/87 (32%), Positives = 48/87 (55%) Frame = +1 Query: 403 RLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDNQEHN 582 ++IH DLKPENI+L +++K+IDFGS+ +++Q+ Sbjct: 225 KIIHCDLKPENIVLYQK----------------------GQASVKVIDFGSSCYEHQKVY 262 Query: 583 SIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + +R YR+PE+ILG + + D+WS Sbjct: 263 TYIQSRFYRSPEVILGHPYDVAIDMWS 289
>DYRK3_DROME (P83102) Putative dual specificity| tyrosine-phosphorylation-regulated kinase 3 homolog (EC 2.7.12.1) Length = 828 Score = 72.0 bits (175), Expect = 1e-12 Identities = 31/96 (32%), Positives = 64/96 (66%), Gaps = 1/96 (1%) Frame = +2 Query: 104 DDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAA 283 D+ G Y+ +++ RY++L +G+G+FG+V++ +D +T E+VA+K+VR+ +++ A Sbjct: 258 DNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQA 317 Query: 284 MIEIDVLNRLAENERYRSL-CVQIQRWFDYRNHICI 388 EI +L+ L +++Y ++ + + +F +RNH CI Sbjct: 318 QEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCI 353 Score = 58.5 bits (140), Expect = 2e-08 Identities = 33/86 (38%), Positives = 47/86 (54%) Frame = +1 Query: 406 LIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDNQEHNS 585 +IH D+KPEN+LL K+ + S IK+IDFGS+ F+NQ + Sbjct: 398 IIHCDMKPENVLL-----------KQQGR-----------SGIKVIDFGSSCFENQRIYT 435 Query: 586 IVSTRHYRAPEIILGLGWSLPCDIWS 663 + +R YRAPE+ILG + D+WS Sbjct: 436 YIQSRFYRAPEVILGGKYGRAIDMWS 461
>SRPK1_HUMAN (Q96SB4) Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1)| (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1) Length = 826 Score = 55.5 bits (132), Expect(2) = 3e-12 Identities = 36/126 (28%), Positives = 64/126 (50%), Gaps = 11/126 (8%) Frame = +2 Query: 47 PPPEREVVARGGASPPWRDDDRD----GHYVFDLGENLTRRYKILSKMGEGTFGRVLECW 214 P E E++ G+ ++D D G+++ +G+ RY ++ K+G G F V W Sbjct: 213 PEQEEEIL---GSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSW 269 Query: 215 DRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAE---NERYRSLCVQIQRWFDYR---- 373 D + +++VA+KVV+S Y + A+ EI +L + N+ R + VQ+ F Sbjct: 270 DIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNG 329 Query: 374 NHICII 391 HIC++ Sbjct: 330 THICMV 335 Score = 42.0 bits (97), Expect = 0.002 Identities = 15/44 (34%), Positives = 28/44 (63%) Frame = +1 Query: 532 IKLIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +K+ D G+ + ++ + TR YR+ E+++G G++ P DIWS Sbjct: 664 VKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWS 707 Score = 35.8 bits (81), Expect(2) = 3e-12 Identities = 17/30 (56%), Positives = 25/30 (83%), Gaps = 2/30 (6%) Frame = +1 Query: 382 MHYMH-ELRLIHTDLKPENILL-VSSEYIK 465 + Y+H + R+IHTD+KPENILL V+ +YI+ Sbjct: 371 LDYLHTKCRIIHTDIKPENILLSVNEQYIR 400
>SRPK1_PONPY (Q5RD27) Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1)| (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1) Length = 655 Score = 55.5 bits (132), Expect(2) = 3e-12 Identities = 36/126 (28%), Positives = 64/126 (50%), Gaps = 11/126 (8%) Frame = +2 Query: 47 PPPEREVVARGGASPPWRDDDRD----GHYVFDLGENLTRRYKILSKMGEGTFGRVLECW 214 P E E++ G+ ++D D G+++ +G+ RY ++ K+G G F V W Sbjct: 42 PEQEEEIL---GSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSW 98 Query: 215 DRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAE---NERYRSLCVQIQRWFDYR---- 373 D + +++VA+KVV+S Y + A+ EI +L + N+ R + VQ+ F Sbjct: 99 DIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNG 158 Query: 374 NHICII 391 HIC++ Sbjct: 159 THICMV 164 Score = 42.0 bits (97), Expect = 0.002 Identities = 15/44 (34%), Positives = 28/44 (63%) Frame = +1 Query: 532 IKLIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +K+ D G+ + ++ + TR YR+ E+++G G++ P DIWS Sbjct: 493 VKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWS 536 Score = 35.8 bits (81), Expect(2) = 3e-12 Identities = 17/30 (56%), Positives = 25/30 (83%), Gaps = 2/30 (6%) Frame = +1 Query: 382 MHYMH-ELRLIHTDLKPENILL-VSSEYIK 465 + Y+H + R+IHTD+KPENILL V+ +YI+ Sbjct: 200 LDYLHTKCRIIHTDIKPENILLSVNEQYIR 229
>SRPK1_MOUSE (O70551) Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1)| (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1) Length = 648 Score = 52.8 bits (125), Expect(2) = 2e-11 Identities = 35/126 (27%), Positives = 63/126 (50%), Gaps = 11/126 (8%) Frame = +2 Query: 47 PPPEREVVARGGASPPWRDDDRD----GHYVFDLGENLTRRYKILSKMGEGTFGRVLECW 214 P E E++ G+ ++D D G+++ +G+ RY ++ K+G G F V W Sbjct: 42 PEQEEEIL---GSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSW 98 Query: 215 DRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAE---NERYRSLCVQIQRWFDYR---- 373 D + +++VA+KVV+S Y + A+ EI +L + N+ + VQ+ F Sbjct: 99 DIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVNG 158 Query: 374 NHICII 391 HIC++ Sbjct: 159 THICMV 164 Score = 42.0 bits (97), Expect = 0.002 Identities = 15/44 (34%), Positives = 28/44 (63%) Frame = +1 Query: 532 IKLIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +K+ D G+ + ++ + TR YR+ E+++G G++ P DIWS Sbjct: 486 VKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWS 529 Score = 35.8 bits (81), Expect(2) = 2e-11 Identities = 17/30 (56%), Positives = 25/30 (83%), Gaps = 2/30 (6%) Frame = +1 Query: 382 MHYMH-ELRLIHTDLKPENILL-VSSEYIK 465 + Y+H + R+IHTD+KPENILL V+ +YI+ Sbjct: 200 LDYLHTKCRIIHTDIKPENILLSVNEQYIR 229
>CDKL5_HUMAN (O76039) Cyclin-dependent kinase-like 5 (EC 2.7.11.22)| (Serine/threonine-protein kinase 9) Length = 1030 Score = 48.5 bits (114), Expect(2) = 2e-11 Identities = 27/98 (27%), Positives = 47/98 (47%), Gaps = 4/98 (4%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGS-- 555 +H+ H+ ++H D+KPEN+L+ ++ +KL DFG Sbjct: 123 IHWCHKNDIVHRDIKPENLLISHND------------------------VLKLCDFGFAR 158 Query: 556 --TAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + +N + V+TR YR+PE++LG + D+WS Sbjct: 159 NLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWS 196 Score = 39.7 bits (91), Expect(2) = 2e-11 Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 4/87 (4%) Frame = +2 Query: 143 NLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAEN 322 N+ +++IL +GEG +G VL+C +ET E VAIK K++D+ E L E Sbjct: 8 NVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIK------KFKDSEENEEVKETTLREL 61 Query: 323 ERYRSL----CVQIQRWFDYRNHICII 391 + R+L V+++ F R + ++ Sbjct: 62 KMLRTLKQENIVELKEAFRRRGKLYLV 88
>DYRK2_HUMAN (Q92630) Dual specificity tyrosine-phosphorylation-regulated kinase| 2 (EC 2.7.12.1) Length = 528 Score = 68.2 bits (165), Expect = 2e-11 Identities = 40/134 (29%), Positives = 77/134 (57%), Gaps = 3/134 (2%) Frame = +2 Query: 77 GGASPPWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVR 256 GG + DDD+ G YV +++ RY++L +G+G+FG+V++ +D + ++VA+K+VR Sbjct: 123 GGPNNGGYDDDQ-GSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR 181 Query: 257 SIRKYRDAAMIEIDVLNRLAENERYRSL-CVQIQRWFDYRNHICII--CTNYALFTLI*S 427 + +++ A EI +L L + ++ ++ + + F +RNHIC+ + L+ LI Sbjct: 182 NEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKK 241 Query: 428 QKTYSLYLPNI*RF 469 K LP + +F Sbjct: 242 NKFQGFSLPLVRKF 255 Score = 67.4 bits (163), Expect = 4e-11 Identities = 36/91 (39%), Positives = 53/91 (58%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 +H+ R+IH DLKPENILL K+ + S IK+IDFGS+ +++ Sbjct: 266 LHKNRIIHCDLKPENILL-----------KQQGR-----------SGIKVIDFGSSCYEH 303 Query: 571 QEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 Q + + +R YRAPE+ILG + +P D+WS Sbjct: 304 QRVYTYIQSRFYRAPEVILGARYGMPIDMWS 334
>CDKL2_PONPY (Q5R754) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 493 Score = 46.2 bits (108), Expect(2) = 4e-10 Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 + H +IH D+KPENIL + KS +KL DFG + Sbjct: 116 FCHSHNIIHRDIKPENIL------------------------VSKSGVVKLCDFGFARTL 151 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 A + + V+TR YRAPE+++G + + D+W+ Sbjct: 152 AAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWA 187 Score = 37.7 bits (86), Expect(2) = 4e-10 Identities = 23/75 (30%), Positives = 40/75 (53%), Gaps = 5/75 (6%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI---RKYRDAAMIEIDVLNRLAENE 325 +Y+ L +GEG++G V++C +++T VAIK + + AM EI +L +L Sbjct: 3 KYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHEN 62 Query: 326 RYRSL--CVQIQRWF 364 L C + +RW+ Sbjct: 63 LVNLLEVCKKKKRWY 77
>CDKL2_HUMAN (Q92772) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE) Length = 493 Score = 44.7 bits (104), Expect(2) = 1e-09 Identities = 28/96 (29%), Positives = 45/96 (46%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 + H +IH D+KPENIL + +S +KL DFG + Sbjct: 116 FCHSHNIIHRDIKPENIL------------------------VSQSGVVKLCDFGFARTL 151 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 A + + V+TR YRAPE+++G + + D+W+ Sbjct: 152 AAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWA 187 Score = 37.7 bits (86), Expect(2) = 1e-09 Identities = 23/75 (30%), Positives = 40/75 (53%), Gaps = 5/75 (6%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI---RKYRDAAMIEIDVLNRLAENE 325 +Y+ L +GEG++G V++C +++T VAIK + + AM EI +L +L Sbjct: 3 KYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHEN 62 Query: 326 RYRSL--CVQIQRWF 364 L C + +RW+ Sbjct: 63 LVNLLEVCKKKKRWY 77
>CDKL2_MACFA (Q4R7T5) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 570 Score = 44.7 bits (104), Expect(2) = 1e-09 Identities = 28/96 (29%), Positives = 45/96 (46%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 + H +IH D+KPENIL + +S +KL DFG + Sbjct: 116 FCHSHNIIHRDIKPENIL------------------------VSQSGVVKLCDFGFARTL 151 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 A + + V+TR YRAPE+++G + + D+W+ Sbjct: 152 AAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWA 187 Score = 37.4 bits (85), Expect(2) = 1e-09 Identities = 23/75 (30%), Positives = 40/75 (53%), Gaps = 5/75 (6%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI---RKYRDAAMIEIDVLNRLAENE 325 +Y+ L +GEG++G V++C +++T VAIK + + AM EI +L +L Sbjct: 3 KYENLGLVGEGSYGMVVKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHEN 62 Query: 326 RYRSL--CVQIQRWF 364 L C + +RW+ Sbjct: 63 LVNLLEVCKKKKRWY 77
>DSK1_SCHPO (P36616) Protein kinase dsk1 (EC 2.7.11.1) (Dis1-suppressing| protein kinase) Length = 544 Score = 50.1 bits (118), Expect(2) = 2e-09 Identities = 30/100 (30%), Positives = 53/100 (53%), Gaps = 8/100 (8%) Frame = +2 Query: 116 GHYVFDLGENLT-RRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIE 292 G++ +GE RRY + K+G G F V +DR + VA+KVVRS YR+ ++ E Sbjct: 66 GYHPVYIGEEFHHRRYVVERKLGWGHFSTVWLAYDRAAKRRVALKVVRSAEHYRETSIDE 125 Query: 293 IDVLNRLAENERY---RSLCVQIQRWFDYRN----HICII 391 I +L ++ E + + + + +F +R H+C++ Sbjct: 126 IRILQKIREGDEKHLGKKHIISLLDYFVHRGPNGAHVCMV 165 Score = 43.9 bits (102), Expect = 4e-04 Identities = 17/44 (38%), Positives = 25/44 (56%) Frame = +1 Query: 532 IKLIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +K+ D G+ + + + V TR YR+PE+ILG W D WS Sbjct: 356 VKIADLGNACWTRKHFTNDVQTRQYRSPEVILGCRWGASADCWS 399 Score = 31.6 bits (70), Expect(2) = 2e-09 Identities = 15/37 (40%), Positives = 26/37 (70%), Gaps = 5/37 (13%) Frame = +1 Query: 382 MHYMH-ELRLIHTDLKPENILLV----SSEYIKVPSS 477 + Y+H E +IHTDLKPEN+L+ + ++I+ P++ Sbjct: 201 LDYLHRECGIIHTDLKPENVLICIDQDALQHIEAPAT 237
>CDKL2_MOUSE (Q9QUK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 568 Score = 45.1 bits (105), Expect(2) = 2e-09 Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 + H +IH D+KPENIL + +S +KL DFG + Sbjct: 116 FCHSHNIIHRDIKPENIL------------------------VSQSGVVKLCDFGFARTL 151 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 A + + V+TR YRAPE+++G + + DIW+ Sbjct: 152 AAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWA 187 Score = 36.2 bits (82), Expect(2) = 2e-09 Identities = 22/75 (29%), Positives = 40/75 (53%), Gaps = 5/75 (6%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI---RKYRDAAMIEIDVLNRLAENE 325 +Y+ L +GEG++G V++C ++++ VAIK + + AM EI +L +L Sbjct: 3 KYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHEN 62 Query: 326 RYRSL--CVQIQRWF 364 L C + +RW+ Sbjct: 63 LVNLLEVCKKKKRWY 77
>CDKL2_RAT (Q5XIT0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 507 Score = 45.1 bits (105), Expect(2) = 2e-09 Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 + H +IH D+KPENIL + +S +KL DFG + Sbjct: 116 FCHSHNIIHRDIKPENIL------------------------VSQSGVVKLCDFGFARTL 151 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 A + + V+TR YRAPE+++G + + DIW+ Sbjct: 152 AAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWA 187 Score = 36.2 bits (82), Expect(2) = 2e-09 Identities = 22/75 (29%), Positives = 40/75 (53%), Gaps = 5/75 (6%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI---RKYRDAAMIEIDVLNRLAENE 325 +Y+ L +GEG++G V++C ++++ VAIK + + AM EI +L +L Sbjct: 3 KYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHEN 62 Query: 326 RYRSL--CVQIQRWF 364 L C + +RW+ Sbjct: 63 LVNLLEVCKKKKRWY 77
>CDKL2_RABIT (Q9TTK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 566 Score = 44.7 bits (104), Expect(2) = 3e-09 Identities = 28/96 (29%), Positives = 45/96 (46%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 + H +IH D+KPENIL + +S +KL DFG + Sbjct: 116 FCHSHNIIHRDIKPENIL------------------------VSQSGVVKLCDFGFARTL 151 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 A + + V+TR YRAPE+++G + + D+W+ Sbjct: 152 AAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWA 187 Score = 36.2 bits (82), Expect(2) = 3e-09 Identities = 22/75 (29%), Positives = 40/75 (53%), Gaps = 5/75 (6%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI---RKYRDAAMIEIDVLNRLAENE 325 +Y+ L +GEG++G V++C ++++ VAIK + + AM EI +L +L Sbjct: 3 KYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHEN 62 Query: 326 RYRSL--CVQIQRWF 364 L C + +RW+ Sbjct: 63 LVNLLEVCKKKKRWY 77
>SRPK2_HUMAN (P78362) Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1)| (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2) Length = 688 Score = 59.7 bits (143), Expect = 8e-09 Identities = 31/97 (31%), Positives = 55/97 (56%), Gaps = 4/97 (4%) Frame = +2 Query: 47 PPPEREVVARGGASPPWRDDDRD----GHYVFDLGENLTRRYKILSKMGEGTFGRVLECW 214 P PE E++ G+ ++D D G++ +G+ RY ++ K+G G F V CW Sbjct: 43 PEPEEEIL---GSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCW 99 Query: 215 DRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAENE 325 D + + +VA+KVV+S + Y + A+ EI +L + E++ Sbjct: 100 DMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESD 136 Score = 43.5 bits (101), Expect = 6e-04 Identities = 16/44 (36%), Positives = 28/44 (63%) Frame = +1 Query: 532 IKLIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +K+ D G+ + ++ + TR YR+ E+++G G+S P DIWS Sbjct: 526 VKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWS 569 Score = 32.0 bits (71), Expect = 1.7 Identities = 14/30 (46%), Positives = 23/30 (76%), Gaps = 2/30 (6%) Frame = +1 Query: 382 MHYMH-ELRLIHTDLKPENILL-VSSEYIK 465 + Y+H + ++IHTD+KPENIL+ V Y++ Sbjct: 201 LDYLHSKCKIIHTDIKPENILMCVDDAYVR 230
>SRPK2_MOUSE (O54781) Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1)| (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2) Length = 681 Score = 59.7 bits (143), Expect = 8e-09 Identities = 31/97 (31%), Positives = 55/97 (56%), Gaps = 4/97 (4%) Frame = +2 Query: 47 PPPEREVVARGGASPPWRDDDRD----GHYVFDLGENLTRRYKILSKMGEGTFGRVLECW 214 P PE E++ G+ ++D D G++ +G+ RY ++ K+G G F V CW Sbjct: 41 PEPEEEIL---GSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCW 97 Query: 215 DRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAENE 325 D + + +VA+KVV+S + Y + A+ EI +L + E++ Sbjct: 98 DMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESD 134 Score = 44.3 bits (103), Expect = 3e-04 Identities = 20/69 (28%), Positives = 39/69 (56%), Gaps = 3/69 (4%) Frame = +1 Query: 466 VPSSKKNSQDEIHCKCLPKSS---AIKLIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLG 636 +P +K + D + P+++ +K+ D G+ + ++ + TR YR+ E+++G G Sbjct: 494 LPKTKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAG 553 Query: 637 WSLPCDIWS 663 +S P DIWS Sbjct: 554 YSTPADIWS 562 Score = 32.0 bits (71), Expect = 1.7 Identities = 14/30 (46%), Positives = 23/30 (76%), Gaps = 2/30 (6%) Frame = +1 Query: 382 MHYMH-ELRLIHTDLKPENILL-VSSEYIK 465 + Y+H + ++IHTD+KPENIL+ V Y++ Sbjct: 199 LDYLHSKCKIIHTDIKPENILMCVDDAYVR 228
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 42.0 bits (97), Expect(2) = 1e-08 Identities = 29/95 (30%), Positives = 40/95 (42%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 YMH ++H DLKPEN+L + + DE S + + DFG Sbjct: 151 YMHSQNIVHRDLKPENLLYI------------DKSDE---------SPLVVADFGIAKRL 189 Query: 559 AFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 D + + Y APE++ G PCDIWS Sbjct: 190 KSDEELLYKPAGSLGYVAPEVLTQDGHGKPCDIWS 224 Score = 37.0 bits (84), Expect(2) = 1e-08 Identities = 30/115 (26%), Positives = 54/115 (46%), Gaps = 7/115 (6%) Frame = +2 Query: 68 VARGGASPPWRDDDRDGH--YVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVA 241 V+ +SP ++D +G +V ++Y +G GTFG V + + ET E VA Sbjct: 5 VSEKESSPKQTEEDSEGKMAHVQPASYVNKKKYVFGKTLGAGTFGVVRQAKNTETGEDVA 64 Query: 242 IKV-----VRSIRKYRDAAMIEIDVLNRLAENERYRSLCVQIQRWFDYRNHICII 391 +K+ ++ + +A E+D+L RL + V + WF+ ++ II Sbjct: 65 VKILIKKALKGNKVQLEALYDELDILQRL-----HHPNIVAFKDWFESKDKFYII 114
>SPK1_CAEEL (Q03563) Serine/threonine-protein kinase spk-1 (EC 2.7.11.1)| Length = 1003 Score = 55.8 bits (133), Expect = 1e-07 Identities = 25/69 (36%), Positives = 42/69 (60%) Frame = +2 Query: 98 RDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRD 277 RD R G++ ++G+ RY ++ K+G G F V WD + + +VA+K+V+S Y + Sbjct: 402 RDYKRGGYHPVNIGDVFNARYHVIRKLGWGHFSTVWLAWDTQDKRFVAMKIVKSAEHYTE 461 Query: 278 AAMIEIDVL 304 AA+ EI +L Sbjct: 462 AALDEIKLL 470 Score = 44.7 bits (104), Expect = 3e-04 Identities = 17/44 (38%), Positives = 27/44 (61%) Frame = +1 Query: 532 IKLIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +K+ D G+ + N + + TR YRA E+++G G+ P DIWS Sbjct: 744 VKIADLGNACWVNHHYTDDIQTRQYRALEVLIGSGYGPPADIWS 787 Score = 33.9 bits (76), Expect = 0.45 Identities = 17/29 (58%), Positives = 23/29 (79%), Gaps = 2/29 (6%) Frame = +1 Query: 388 YMHE-LRLIHTDLKPENILL-VSSEYIKV 468 YMHE +IHTD+KPEN+L+ +S E IK+ Sbjct: 544 YMHEKCGIIHTDIKPENVLITMSREEIKI 572
>CHK2_HUMAN (O96017) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1)| Length = 543 Score = 44.3 bits (103), Expect(2) = 1e-07 Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 5/99 (5%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+HE +IH DLKPEN+LL +SQ+E CL IK+ DFG + Sbjct: 335 VQYLHENGIIHRDLKPENVLL-------------SSQEE---DCL-----IKITDFGHSK 373 Query: 562 F--DNQEHNSIVSTRHYRAPEIILGL---GWSLPCDIWS 663 + ++ T Y APE+++ + G++ D WS Sbjct: 374 ILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWS 412 Score = 31.2 bits (69), Expect(2) = 1e-07 Identities = 26/82 (31%), Positives = 45/82 (54%), Gaps = 6/82 (7%) Frame = +2 Query: 164 ILSK-MGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEID-VLNRLAENERYRS 337 I+SK +G G G V ++R+T + VAIK++ S RK+ + E D LN E E + Sbjct: 221 IMSKTLGSGACGEVKLAFERKTCKKVAIKII-SKRKFAIGSAREADPALNVETEIEILKK 279 Query: 338 L----CVQIQRWFDYRNHICII 391 L ++I+ +FD ++ ++ Sbjct: 280 LNHPCIIKIKNFFDAEDYYIVL 301
>IME2_YEAST (P32581) Meiosis induction protein kinase IME2/SME1 (EC 2.7.11.1)| Length = 645 Score = 55.5 bits (132), Expect = 1e-07 Identities = 35/97 (36%), Positives = 53/97 (54%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++HE H DLKPENIL+ PS++ ++ ++ + IKL DFG Sbjct: 181 LKHIHEHNFFHRDLKPENILI-------TPSTQYFEKEYMNQIGYQDNYVIKLADFGLAR 233 Query: 562 F--DNQEHNSIVSTRHYRAPEIILGLG-WSLPCDIWS 663 + + + VSTR YR+PEI+L G +S P DIW+ Sbjct: 234 HVENKNPYTAYVSTRWYRSPEILLRSGYYSKPLDIWA 270
>HIPK4_RAT (Q4V793) Homeodomain-interacting protein kinase 4 (EC 2.7.11.1)| Length = 616 Score = 55.1 bits (131), Expect = 2e-07 Identities = 34/94 (36%), Positives = 48/94 (51%), Gaps = 3/94 (3%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + EL +IH DLKPENI+LV D+ C +K+IDFGS + + Sbjct: 127 LKELAIIHADLKPENIMLV---------------DQTRCPF-----RVKVIDFGSASIFS 166 Query: 571 QEH---NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + +R YRAPEI+LGL + D+WS Sbjct: 167 EVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWS 200 Score = 38.5 bits (88), Expect = 0.018 Identities = 16/34 (47%), Positives = 24/34 (70%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVVRS 259 Y I+ +G+GTFG V + W R T E VAIK++++ Sbjct: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKN 44
>HIPK4_MACFA (Q8WP28) Homeodomain-interacting protein kinase 4 (EC 2.7.11.1)| Length = 616 Score = 55.1 bits (131), Expect = 2e-07 Identities = 34/94 (36%), Positives = 48/94 (51%), Gaps = 3/94 (3%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + EL +IH DLKPENI+LV D+ C +K+IDFGS + + Sbjct: 127 LKELAIIHADLKPENIMLV---------------DQTRCPF-----RVKVIDFGSASIFS 166 Query: 571 QEH---NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + +R YRAPEI+LGL + D+WS Sbjct: 167 EVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWS 200 Score = 38.5 bits (88), Expect = 0.018 Identities = 16/34 (47%), Positives = 24/34 (70%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVVRS 259 Y I+ +G+GTFG V + W R T E VAIK++++ Sbjct: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKN 44
>HIPK4_HUMAN (Q8NE63) Homeodomain-interacting protein kinase 4 (EC 2.7.11.1)| Length = 616 Score = 55.1 bits (131), Expect = 2e-07 Identities = 34/94 (36%), Positives = 48/94 (51%), Gaps = 3/94 (3%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 + EL +IH DLKPENI+LV D+ C +K+IDFGS + + Sbjct: 127 LKELAIIHADLKPENIMLV---------------DQTRCPF-----RVKVIDFGSASIFS 166 Query: 571 QEH---NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + +R YRAPEI+LGL + D+WS Sbjct: 167 EVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWS 200 Score = 38.5 bits (88), Expect = 0.018 Identities = 16/34 (47%), Positives = 24/34 (70%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVVRS 259 Y I+ +G+GTFG V + W R T E VAIK++++ Sbjct: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKN 44
>STK23_MOUSE (Q9Z0G2) Serine/threonine-protein kinase 23 (EC 2.7.11.1)| (Muscle-specific serine kinase 1) (MSSK-1) Length = 565 Score = 54.7 bits (130), Expect = 2e-07 Identities = 25/76 (32%), Positives = 45/76 (59%) Frame = +2 Query: 98 RDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRD 277 +D + G+Y +G+ RY ++ K+G G F V CWD + + +VA+KVV+S Y + Sbjct: 58 KDYCKGGYYPVKIGDLFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTE 117 Query: 278 AAMIEIDVLNRLAENE 325 A+ EI +L + +++ Sbjct: 118 TAVDEIKLLKCVRDSD 133 Score = 40.0 bits (92), Expect = 0.006 Identities = 16/44 (36%), Positives = 26/44 (59%) Frame = +1 Query: 532 IKLIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 IK+ D G+ + ++ + TR YRA E+++G + P DIWS Sbjct: 403 IKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWS 446 Score = 33.1 bits (74), Expect = 0.77 Identities = 16/30 (53%), Positives = 23/30 (76%), Gaps = 2/30 (6%) Frame = +1 Query: 382 MHYMH-ELRLIHTDLKPENILL-VSSEYIK 465 + Y+H + ++IHTD+KPENILL V YI+ Sbjct: 198 LDYLHTKCKIIHTDIKPENILLCVGDAYIR 227
>SPK1_CAEBR (Q61IS6) Serine/threonine-protein kinase spk-1 (EC 2.7.11.1)| Length = 771 Score = 54.3 bits (129), Expect = 3e-07 Identities = 24/69 (34%), Positives = 41/69 (59%) Frame = +2 Query: 98 RDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRD 277 RD R G++ ++G+ RY ++ K+G G F V WD + + + A+K+V+S Y + Sbjct: 114 RDYKRGGYHPVNIGDVFNSRYHVIRKLGWGHFSTVWLAWDTQEKRFTAMKIVKSAEHYTE 173 Query: 278 AAMIEIDVL 304 AA+ EI +L Sbjct: 174 AALDEIKLL 182 Score = 44.7 bits (104), Expect = 3e-04 Identities = 17/44 (38%), Positives = 27/44 (61%) Frame = +1 Query: 532 IKLIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +K+ D G+ + N + + TR YRA E+++G G+ P DIWS Sbjct: 523 VKIADLGNACWVNHHYTDDIQTRQYRALEVLIGSGYGPPADIWS 566 Score = 34.7 bits (78), Expect = 0.26 Identities = 17/31 (54%), Positives = 24/31 (77%), Gaps = 2/31 (6%) Frame = +1 Query: 382 MHYMHE-LRLIHTDLKPENILL-VSSEYIKV 468 + YMHE +IHTD+KPEN+L+ +S E IK+ Sbjct: 254 LRYMHEKCGIIHTDIKPENVLITMSREEIKI 284
>MK09_CHICK (P79996) Mitogen-activated protein kinase 9 (EC 2.7.11.24)| (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) Length = 382 Score = 53.9 bits (128), Expect = 4e-07 Identities = 33/94 (35%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 176 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 N V TR+YRAPE+ILG+G+ DIWS Sbjct: 177 CTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWS 210
>MK09_RAT (P49186) Mitogen-activated protein kinase 9 (EC 2.7.11.24)| (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (SAPK-alpha) (p54-alpha) Length = 423 Score = 53.9 bits (128), Expect = 4e-07 Identities = 33/94 (35%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 176 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 N V TR+YRAPE+ILG+G+ DIWS Sbjct: 177 CTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWS 210
>MK09_MOUSE (Q9WTU6) Mitogen-activated protein kinase 9 (EC 2.7.11.24)| (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) Length = 423 Score = 53.9 bits (128), Expect = 4e-07 Identities = 33/94 (35%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 176 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 N V TR+YRAPE+ILG+G+ DIWS Sbjct: 177 CTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWS 210
>MK09_HUMAN (P45984) Mitogen-activated protein kinase 9 (EC 2.7.11.24)| (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55) Length = 424 Score = 53.9 bits (128), Expect = 4e-07 Identities = 33/94 (35%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 176 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 N V TR+YRAPE+ILG+G+ DIWS Sbjct: 177 CTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWS 210
>PRP4B_MOUSE (Q61136) Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1)| (PRP4 pre-mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase) Length = 1007 Score = 53.9 bits (128), Expect = 4e-07 Identities = 28/108 (25%), Positives = 61/108 (56%), Gaps = 6/108 (5%) Frame = +2 Query: 86 SPPWRDD--DRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDR-ETREYVAIKVVR 256 +P RD+ D +G+Y ++GE L +RY + G+G F V+ D + VA+K++R Sbjct: 661 NPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR 720 Query: 257 SIRKYRDAAMIEIDVLNRLAE---NERYRSLCVQIQRWFDYRNHICII 391 + + + E++ L +L + ++++ C+++ R F ++ H+C++ Sbjct: 721 NNELMQKTGLKELEFLKKLNDADPDDKFH--CLRLFRHFYHKQHLCLV 766 Score = 45.1 bits (105), Expect = 2e-04 Identities = 31/88 (35%), Positives = 43/88 (48%), Gaps = 2/88 (2%) Frame = +1 Query: 406 LIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAF--DNQEH 579 ++H D+KP+NIL+ S+ I +KL DFGS + DN Sbjct: 811 ILHADIKPDNILVNESKTI-----------------------LKLCDFGSASHVADNDIT 847 Query: 580 NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +VS R YRAPEII+G + D+WS Sbjct: 848 PYLVS-RFYRAPEIIIGKSYDYGIDMWS 874
>PRP4B_HUMAN (Q13523) Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1)| (PRP4 pre-mRNA-processing factor 4 homolog) (PRP4 kinase) Length = 1007 Score = 53.9 bits (128), Expect = 4e-07 Identities = 28/108 (25%), Positives = 61/108 (56%), Gaps = 6/108 (5%) Frame = +2 Query: 86 SPPWRDD--DRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDR-ETREYVAIKVVR 256 +P RD+ D +G+Y ++GE L +RY + G+G F V+ D + VA+K++R Sbjct: 661 NPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR 720 Query: 257 SIRKYRDAAMIEIDVLNRLAE---NERYRSLCVQIQRWFDYRNHICII 391 + + + E++ L +L + ++++ C+++ R F ++ H+C++ Sbjct: 721 NNELMQKTGLKELEFLKKLNDADPDDKFH--CLRLFRHFYHKQHLCLV 766 Score = 45.1 bits (105), Expect = 2e-04 Identities = 31/88 (35%), Positives = 43/88 (48%), Gaps = 2/88 (2%) Frame = +1 Query: 406 LIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAF--DNQEH 579 ++H D+KP+NIL+ S+ I +KL DFGS + DN Sbjct: 811 ILHADIKPDNILVNESKTI-----------------------LKLCDFGSASHVADNDIT 847 Query: 580 NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +VS R YRAPEII+G + D+WS Sbjct: 848 PYLVS-RFYRAPEIIIGKSYDYGIDMWS 874
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 53.5 bits (127), Expect = 5e-07 Identities = 36/94 (38%), Positives = 51/94 (54%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-STAF 564 YMH+ ++H DLKPENILL KN +D I IK+IDFG ST F Sbjct: 182 YMHKNNVVHRDLKPENILL----------ETKNKEDMI----------IKIIDFGLSTHF 221 Query: 565 D-NQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + +++ + T +Y AP+++ G + CDIWS Sbjct: 222 EYSKKMKDKIGTAYYIAPDVLHGT-YDEKCDIWS 254 Score = 33.1 bits (74), Expect = 0.77 Identities = 27/117 (23%), Positives = 58/117 (49%), Gaps = 7/117 (5%) Frame = +2 Query: 110 RDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVV--RSIRKYRD-- 277 R G ++ + +YK + +G+G+FG V+ D+ T AIKV+ + +++ D Sbjct: 53 RPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQ 112 Query: 278 AAMIEIDVLNRLAENERYRSLCVQIQRWFDYRNHICIICTNYA---LFTLI*SQKTY 439 + + E+++L L +++ +F+ N+ ++ Y+ LF I S+K + Sbjct: 113 SLLREVELLKMLDHIN-----IMKLYEFFEDNNYYYLVSDVYSGGELFDEIISRKRF 164
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 53.5 bits (127), Expect = 5e-07 Identities = 36/94 (38%), Positives = 51/94 (54%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-STAF 564 YMH+ ++H DLKPENILL KN +D I IK+IDFG ST F Sbjct: 182 YMHKNNVVHRDLKPENILL----------ETKNKEDMI----------IKIIDFGLSTHF 221 Query: 565 D-NQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + +++ + T +Y AP+++ G + CDIWS Sbjct: 222 EYSKKMKDKIGTAYYIAPDVLHGT-YDEKCDIWS 254 Score = 32.7 bits (73), Expect = 1.0 Identities = 27/117 (23%), Positives = 57/117 (48%), Gaps = 7/117 (5%) Frame = +2 Query: 110 RDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVV--RSIRKYRD-- 277 R G ++ + +YK + +G+G+FG V+ D+ T AIKV+ + +++ D Sbjct: 53 RPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKE 112 Query: 278 AAMIEIDVLNRLAENERYRSLCVQIQRWFDYRNHICIICTNYA---LFTLI*SQKTY 439 + + E+++L L +++ +F+ N+ ++ Y LF I S+K + Sbjct: 113 SLLREVELLKMLDHIN-----IMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRF 164
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 53.5 bits (127), Expect = 5e-07 Identities = 36/94 (38%), Positives = 51/94 (54%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-STAF 564 YMH+ ++H DLKPENILL KN +D I IK+IDFG ST F Sbjct: 182 YMHKNNVVHRDLKPENILL----------ETKNKEDMI----------IKIIDFGLSTHF 221 Query: 565 D-NQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + +++ + T +Y AP+++ G + CDIWS Sbjct: 222 EYSKKMKDKIGTAYYIAPDVLHGT-YDEKCDIWS 254 Score = 33.1 bits (74), Expect = 0.77 Identities = 27/117 (23%), Positives = 58/117 (49%), Gaps = 7/117 (5%) Frame = +2 Query: 110 RDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVV--RSIRKYRD-- 277 R G ++ + +YK + +G+G+FG V+ D+ T AIKV+ + +++ D Sbjct: 53 RPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQ 112 Query: 278 AAMIEIDVLNRLAENERYRSLCVQIQRWFDYRNHICIICTNYA---LFTLI*SQKTY 439 + + E+++L L +++ +F+ N+ ++ Y+ LF I S+K + Sbjct: 113 SLLREVELLKMLDHIN-----IMKLYEFFEDNNYYYLVSDVYSGGELFDEIISRKRF 164
>MAST3_HUMAN (O60307) Microtubule-associated serine/threonine-protein kinase 3| (EC 2.7.11.1) Length = 1309 Score = 43.1 bits (100), Expect(2) = 7e-07 Identities = 30/96 (31%), Positives = 45/96 (46%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP+N+L+ S +IK+ D K S A L + G Sbjct: 478 LEYLHNYGIVHRDLKPDNLLITSLGHIKL-------TDFGLSKIGLMSMATNLYE-GHIE 529 Query: 562 FDNQE--HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 D +E + T Y APE+I G+ P D W+ Sbjct: 530 KDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWA 565 Score = 29.6 bits (65), Expect(2) = 7e-07 Identities = 21/82 (25%), Positives = 37/82 (45%), Gaps = 4/82 (4%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVVRS----IRKYRDAAMIEIDVLNRLAENE 325 ++ + + G +G V R+TR+ AIK + +R +E D+L AEN Sbjct: 367 FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILT-FAENP 425 Query: 326 RYRSLCVQIQRWFDYRNHICII 391 S+ F+ R H+C++ Sbjct: 426 FVVSMFCS----FETRRHLCMV 443
>SLK_MOUSE (O54988) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4) Length = 1233 Score = 37.7 bits (86), Expect(2) = 7e-07 Identities = 31/123 (25%), Positives = 51/123 (41%), Gaps = 10/123 (8%) Frame = +1 Query: 325 EIQIPLCPNSKMV*LSQPY--MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDE 498 E++ PL + V Q ++Y+H+ ++IH DLK NIL Sbjct: 122 ELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFT----------------- 164 Query: 499 IHCKCLPKSSAIKLIDFGSTAFDN---QEHNSIVSTRHYRAPEIIL-----GLGWSLPCD 654 IKL DFG +A + Q +S + T ++ APE+++ + D Sbjct: 165 -------LDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKAD 217 Query: 655 IWS 663 +WS Sbjct: 218 VWS 220 Score = 35.0 bits (79), Expect(2) = 7e-07 Identities = 18/51 (35%), Positives = 33/51 (64%), Gaps = 2/51 (3%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVV--RSIRKYRDAAMIEIDVL 304 ++I+ ++G+G FG+V + ++ET A KV+ +S + D M+EID+L Sbjct: 34 WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELED-YMVEIDIL 83
>SLK_RAT (O08815) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1206 Score = 37.7 bits (86), Expect(2) = 7e-07 Identities = 31/123 (25%), Positives = 51/123 (41%), Gaps = 10/123 (8%) Frame = +1 Query: 325 EIQIPLCPNSKMV*LSQPY--MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDE 498 E++ PL + V Q ++Y+H+ ++IH DLK NIL Sbjct: 122 ELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFT----------------- 164 Query: 499 IHCKCLPKSSAIKLIDFGSTAFDN---QEHNSIVSTRHYRAPEIIL-----GLGWSLPCD 654 IKL DFG +A + Q +S + T ++ APE+++ + D Sbjct: 165 -------LDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKAD 217 Query: 655 IWS 663 +WS Sbjct: 218 VWS 220 Score = 35.0 bits (79), Expect(2) = 7e-07 Identities = 18/51 (35%), Positives = 33/51 (64%), Gaps = 2/51 (3%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVV--RSIRKYRDAAMIEIDVL 304 ++I+ ++G+G FG+V + ++ET A KV+ +S + D M+EID+L Sbjct: 34 WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELED-YMVEIDIL 83
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 40.0 bits (92), Expect(2) = 7e-07 Identities = 37/123 (30%), Positives = 55/123 (44%), Gaps = 4/123 (3%) Frame = +2 Query: 35 GAGDPPPEREVVARGGASPPWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECW 214 G G P RE VA GA+ G NL RY++ +G+GT+G+V Sbjct: 16 GLGAPGSPREAVA--GATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRAT 73 Query: 215 DRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAENERYRSL----CVQIQRWFDYRNHI 382 +R + VAIK +R +D E D+++ E E SL + I F+ ++ I Sbjct: 74 ERFSGRVVAIKSIR-----KDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKI 128 Query: 383 CII 391 II Sbjct: 129 VII 131 Score = 32.7 bits (73), Expect(2) = 7e-07 Identities = 25/80 (31%), Positives = 37/80 (46%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 +HY H+ ++H DLK ENILL + IK+ + L + GS Sbjct: 166 VHYCHKNGVVHRDLKLENILLDDNCNIKIA--------DFGLSNLYQKDKFLQTFCGSPL 217 Query: 562 FDNQEHNSIVSTRHYRAPEI 621 + + E IV+ R YR PE+ Sbjct: 218 YASPE---IVNGRPYRGPEV 234
>PAKM_DROME (Q9VXE5) Serine/threonine-protein kinase PAK mbt (EC 2.7.11.1)| (p21-activated kinase-related protein) (Protein mushroom bodies tiny) Length = 639 Score = 40.4 bits (93), Expect(2) = 7e-07 Identities = 28/95 (29%), Positives = 42/95 (44%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 Y+H +IH D+K ++ILL + +KL DFG A Sbjct: 477 YLHSQGVIHRDIKSDSILLAA------------------------DGRVKLSDFGFCAQV 512 Query: 568 NQE---HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +QE S+V T ++ +PE+I L + DIWS Sbjct: 513 SQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWS 547 Score = 32.3 bits (72), Expect(2) = 7e-07 Identities = 33/134 (24%), Positives = 52/134 (38%), Gaps = 15/134 (11%) Frame = +2 Query: 5 RGSARVKXLDGAGDPPPEREVVARGGASPPWRDDDRDGHYVF-----------DLGENLT 151 + ++R G ++ A GGA+ + D R H F D ENL Sbjct: 310 KSASRASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFRAALQMVVSAGDPRENLD 369 Query: 152 RRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAEN--- 322 +K+GEG+ G V D+ T VA+K + ++ R + V+ R + Sbjct: 370 H----FNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNI 425 Query: 323 -ERYRSLCVQIQRW 361 E Y S V + W Sbjct: 426 VETYSSFLVNDELW 439
>SLK_HUMAN (Q9H2G2) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9) Length = 1235 Score = 37.7 bits (86), Expect(2) = 9e-07 Identities = 31/123 (25%), Positives = 51/123 (41%), Gaps = 10/123 (8%) Frame = +1 Query: 325 EIQIPLCPNSKMV*LSQPY--MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDE 498 E++ PL + V Q ++Y+H+ ++IH DLK NIL Sbjct: 122 ELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT----------------- 164 Query: 499 IHCKCLPKSSAIKLIDFGSTAFDN---QEHNSIVSTRHYRAPEIIL-----GLGWSLPCD 654 IKL DFG +A + Q +S + T ++ APE+++ + D Sbjct: 165 -------LDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKAD 217 Query: 655 IWS 663 +WS Sbjct: 218 VWS 220 Score = 34.7 bits (78), Expect(2) = 9e-07 Identities = 18/51 (35%), Positives = 33/51 (64%), Gaps = 2/51 (3%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVV--RSIRKYRDAAMIEIDVL 304 ++I+ ++G+G FG+V + ++ET A KV+ +S + D M+EID+L Sbjct: 34 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELED-YMVEIDIL 83
>GSK3H_DICDI (P51136) Glycogen synthase kinase-3 homolog (EC 2.7.11.26) (GSK-3)| Length = 467 Score = 52.8 bits (125), Expect = 9e-07 Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST- 558 ++Y+H L + H D+KP+N+LL +S +S +KL DFGS Sbjct: 167 INYIHSLGICHRDIKPQNLLLDTS-----------------------TSTLKLCDFGSAK 203 Query: 559 -AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + + S + +RHYRAPE+I G ++ D+WS Sbjct: 204 ILIKGETNVSYICSRHYRAPELIFGSTNYTTTIDVWS 240 Score = 31.2 bits (69), Expect = 2.9 Identities = 29/119 (24%), Positives = 53/119 (44%) Frame = +2 Query: 176 MGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAENERYRSLCVQIQ 355 +G G+FG V + +T+E VAIK ++ +++RY++ +QI Sbjct: 62 IGNGSFGVVTQAIVADTKEVVAIK--------------------KVLQDQRYKNRELQIM 101 Query: 356 RWFDYRNHICIICTNYALFTLI*SQKTYSLYLPNI*RFQVPRRIHKMRYTASACQSPVP 532 + NHI I+ + +T +YL N+ VP ++++ S + PVP Sbjct: 102 KML---NHINIVSLKNSFYT----SDNDEVYL-NLVLEYVPDTVYRVSRHYSMSKQPVP 152
>STK23_HUMAN (Q9UPE1) Serine/threonine-protein kinase 23 (EC 2.7.11.1)| (Muscle-specific serine kinase 1) (MSSK-1) Length = 533 Score = 52.8 bits (125), Expect = 9e-07 Identities = 24/76 (31%), Positives = 45/76 (59%) Frame = +2 Query: 98 RDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRD 277 +D + G++ +G+ RY ++ K+G G F V CWD + + +VA+KVV+S Y + Sbjct: 59 KDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTE 118 Query: 278 AAMIEIDVLNRLAENE 325 A+ EI +L + +++ Sbjct: 119 TAVDEIKLLKCVRDSD 134 Score = 40.0 bits (92), Expect = 0.006 Identities = 16/44 (36%), Positives = 26/44 (59%) Frame = +1 Query: 532 IKLIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 IK+ D G+ + ++ + TR YRA E+++G + P DIWS Sbjct: 371 IKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWS 414 Score = 33.1 bits (74), Expect = 0.77 Identities = 16/30 (53%), Positives = 23/30 (76%), Gaps = 2/30 (6%) Frame = +1 Query: 382 MHYMH-ELRLIHTDLKPENILL-VSSEYIK 465 + Y+H + ++IHTD+KPENILL V YI+ Sbjct: 199 LDYLHTKCKIIHTDIKPENILLCVGDAYIR 228
>MK08A_CYPCA (Q90327) Mitogen-activated protein kinase 8A (EC 2.7.11.24)| (Stress-activated protein kinase JNKa) (c-Jun N-terminal kinase A) Length = 427 Score = 52.4 bits (124), Expect = 1e-06 Identities = 32/94 (34%), Positives = 44/94 (46%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 176 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 V TR+YRAPE+ILG+G+ DIWS Sbjct: 177 ATGLLMTPYVVTRYYRAPEVILGMGYQANVDIWS 210 Score = 29.6 bits (65), Expect = 8.5 Identities = 31/108 (28%), Positives = 45/108 (41%), Gaps = 3/108 (2%) Frame = +2 Query: 122 YVFDLGEN---LTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIE 292 Y D+G++ + +RY+ L +G G G V +D VAIK + R ++ Sbjct: 11 YSVDVGDSTFTVLKRYQNLRPIGSGAQGIVCSAYDHNLERNVAIK--KLSRPFQ------ 62 Query: 293 IDVLNRLAENERYRSLCVQIQRWFDYRNHICIICTNYALFTLI*SQKT 436 N+ YR L + Y NH IIC L + SQKT Sbjct: 63 ----NQTHAKRAYRELVL-----MKYVNHKNIIC----LLNVFTSQKT 97
>JNK1_CAEEL (Q8WQG9) Stress-activated protein kinase jnk-1 (EC 2.7.11.24)| Length = 463 Score = 52.4 bits (124), Expect = 1e-06 Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--S 555 + ++H +IH DLKP NI++ S +K++DFG Sbjct: 232 IRHLHSAGIIHRDLKPSNIVVRSD------------------------CTLKILDFGLAR 267 Query: 556 TAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 TA + V TR+YRAPE+ILG+G+ D+WS Sbjct: 268 TAIEAFMMTPYVVTRYYRAPEVILGMGYKENVDVWS 303
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 38.9 bits (89), Expect(2) = 1e-06 Identities = 27/87 (31%), Positives = 45/87 (51%), Gaps = 4/87 (4%) Frame = +2 Query: 143 NLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAEN 322 NL RY++ +G+GT+G+V +R + VAIK +R +D E+D+++ E Sbjct: 51 NLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIR-----KDKIKDELDMVHIRREI 105 Query: 323 ERYRSL----CVQIQRWFDYRNHICII 391 E SL + I F+ ++ I II Sbjct: 106 EIMSSLNHPHIISIYEVFENKDKIVII 132 Score = 32.7 bits (73), Expect(2) = 1e-06 Identities = 25/80 (31%), Positives = 37/80 (46%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 +HY H+ ++H DLK ENILL + IK+ + L + GS Sbjct: 167 VHYCHKNGVVHRDLKLENILLDDNCNIKIA--------DFGLSNLYQKDKFLQTFCGSPL 218 Query: 562 FDNQEHNSIVSTRHYRAPEI 621 + + E IV+ R YR PE+ Sbjct: 219 YASPE---IVNGRPYRGPEV 235
>MK08B_CYPCA (O42099) Mitogen-activated protein kinase 8B (EC 2.7.11.24)| (Stress-activated protein kinase JNKb) (c-Jun N-terminal kinase B) Length = 427 Score = 52.0 bits (123), Expect = 2e-06 Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 176 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 V TR+YRAPE+ILG+G+ D+WS Sbjct: 177 ATGLLMTPYVVTRYYRAPEVILGMGYQANVDVWS 210
>DUN1_YEAST (P39009) DNA damage response protein kinase DUN1 (EC 2.7.11.1)| Length = 513 Score = 52.0 bits (123), Expect = 2e-06 Identities = 34/99 (34%), Positives = 53/99 (53%), Gaps = 5/99 (5%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKN---SQDEIHCKCLPKSSAIKLIDFG 552 + Y+HE +IH D+KPENILL + + PS + +DEI + +K+ DFG Sbjct: 316 LKYLHEQNIIHRDIKPENILLNITRR-ENPSQVQLGPWDEDEIDIQ-------VKIADFG 367 Query: 553 STAF--DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 F + Q N++ T Y APE++ G++ D+WS Sbjct: 368 LAKFTGEMQFTNTLCGTPSYVAPEVLTKKGYTSKVDLWS 406
>JNK1_ANCCA (Q9U6D2) Stress-activated protein kinase JNK-1 (EC 2.7.11.24)| Length = 376 Score = 52.0 bits (123), Expect = 2e-06 Identities = 31/94 (32%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 176 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + V TR+YRAPE+ILG+G+ D+WS Sbjct: 177 VEAFMMTPYVVTRYYRAPEVILGMGYGENVDVWS 210 Score = 29.6 bits (65), Expect = 8.5 Identities = 21/72 (29%), Positives = 34/72 (47%), Gaps = 11/72 (15%) Frame = +2 Query: 113 DGHYVFDLGEN---LTRRYKILSKMGEGTFGRVLECWDRETREYVAIK--------VVRS 259 + +YV +GE + +RY+ L +G G G V D T + VAIK V + Sbjct: 8 ENYYVVPIGETQMVILKRYENLRLIGSGAQGIVCAATDMVTNKPVAIKKLSRPFQNVTHA 67 Query: 260 IRKYRDAAMIEI 295 R YR+ ++ + Sbjct: 68 KRAYREFILMNL 79
>KS6A5_CHICK (Q5F3L1) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 789 Score = 52.0 bits (123), Expect = 2e-06 Identities = 31/95 (32%), Positives = 43/95 (45%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAF- 564 +MH++ ++H DLKPEN+L +S IK+IDFG Sbjct: 524 HMHDVGVVHRDLKPENLLFTDET---------------------DNSEIKIIDFGFARLK 562 Query: 565 --DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 DNQ + T HY APE+ G+ CD+WS Sbjct: 563 PPDNQPLKTPCFTLHYAAPELFNHNGYDESCDLWS 597 Score = 32.3 bits (72), Expect = 1.3 Identities = 29/100 (29%), Positives = 42/100 (42%), Gaps = 6/100 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-ST 558 + ++H+L +I+ D+K ENILL S + + L DFG S Sbjct: 155 LEHLHKLGIIYRDIKLENILLDSDGH------------------------VVLTDFGLSK 190 Query: 559 AF---DNQEHNSIVSTRHYRAPEIILG--LGWSLPCDIWS 663 F +N+ S T Y AP+I+ G G D WS Sbjct: 191 EFLTDENERAYSFCGTIEYMAPDIVRGGDTGHDKAVDWWS 230 Score = 29.6 bits (65), Expect = 8.5 Identities = 20/71 (28%), Positives = 31/71 (43%) Frame = +2 Query: 41 GDPPPEREVVARGGASPPWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDR 220 GD P +AR S +D HY DL E +GEG+F +C + Sbjct: 389 GDERPGTTTIAR---SAMMKDSPFFQHYELDLKEK---------PLGEGSFSICRKCLHK 436 Query: 221 ETREYVAIKVV 253 +T + A+K++ Sbjct: 437 KTSQEYAVKII 447
>SKY1_YEAST (Q03656) Serine/threonine-protein kinase SKY1 (EC 2.7.11.1) (SRPK)| Length = 742 Score = 46.2 bits (108), Expect = 9e-05 Identities = 17/44 (38%), Positives = 28/44 (63%) Frame = +1 Query: 532 IKLIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 IK+ D G+ + ++ + + + TR YR+PE++LG W DIWS Sbjct: 546 IKIADLGNACWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWS 589 Score = 39.7 bits (91), Expect(2) = 2e-06 Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 3/78 (3%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRL--AENER 328 RY ++ K+G G F V D +VA+K+VR + Y +AA EI +L R+ A+N + Sbjct: 157 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTK 216 Query: 329 YRSL-CVQIQRWFDYRNH 379 S+ I + D+ NH Sbjct: 217 EDSMGANHILKLLDHFNH 234 Score = 31.6 bits (70), Expect(2) = 2e-06 Identities = 15/31 (48%), Positives = 20/31 (64%) Frame = +1 Query: 352 SKMV*LSQPYMHYMHELRLIHTDLKPENILL 444 SK + L YMH +IHTD+KPEN+L+ Sbjct: 274 SKQLLLGLDYMH--RRCGIIHTDIKPENVLM 302
>MK10_RAT (P49187) Mitogen-activated protein kinase 10 (EC 2.7.11.24)| (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (SAPK-beta) (p54-beta) Length = 464 Score = 51.6 bits (122), Expect = 2e-06 Identities = 32/94 (34%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 179 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 214 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + V TR+YRAPE+ILG+G+ DIWS Sbjct: 215 GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWS 248
>MK10_MOUSE (Q61831) Mitogen-activated protein kinase 10 (EC 2.7.11.24)| (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) Length = 464 Score = 51.6 bits (122), Expect = 2e-06 Identities = 32/94 (34%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 179 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 214 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + V TR+YRAPE+ILG+G+ DIWS Sbjct: 215 GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWS 248
>MK10_HUMAN (P53779) Mitogen-activated protein kinase 10 (EC 2.7.11.24)| (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) Length = 464 Score = 51.6 bits (122), Expect = 2e-06 Identities = 32/94 (34%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 179 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 214 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + V TR+YRAPE+ILG+G+ DIWS Sbjct: 215 GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWS 248
>KN8R_YEAST (P53739) Probable serine/threonine-protein kinase YNR047W (EC| 2.7.11.1) Length = 893 Score = 51.6 bits (122), Expect = 2e-06 Identities = 33/94 (35%), Positives = 45/94 (47%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H L I+ DLKPENILL S +I + + Q + + K SA + Sbjct: 609 LEYLHLLGFIYRDLKPENILLHQSGHIMLSDFDLSIQAKDSKVPVVKGSAQSTLVDTKIC 668 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 D NS V T Y APE+I G G + D W+ Sbjct: 669 SDGFRTNSFVGTEEYIAPEVIRGNGHTAAVDWWT 702
>KS6A5_MOUSE (Q8C050) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK) Length = 863 Score = 51.6 bits (122), Expect = 2e-06 Identities = 31/95 (32%), Positives = 45/95 (47%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAF- 564 +MH++ ++H DLKPEN+L + D + IK+IDFG Sbjct: 598 HMHDVGVVHRDLKPENLLFT------------DENDNLE---------IKVIDFGFARLK 636 Query: 565 --DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 DNQ + T HY APE++ G+ CD+WS Sbjct: 637 PPDNQPLKTPCFTLHYAAPELLTHNGYDESCDLWS 671 Score = 31.2 bits (69), Expect = 2.9 Identities = 27/100 (27%), Positives = 42/100 (42%), Gaps = 6/100 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST- 558 + ++H+L +I+ D+K ENILL S+ + + L DFG + Sbjct: 164 LEHLHKLGIIYRDIKLENILLDSNGH------------------------VVLTDFGLSK 199 Query: 559 ---AFDNQEHNSIVSTRHYRAPEIILG--LGWSLPCDIWS 663 A + + S T Y AP+I+ G G D WS Sbjct: 200 EFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS 239
>MK08_BRARE (Q9DGD9) Mitogen-activated protein kinase 8 (EC 2.7.11.24)| (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) Length = 384 Score = 51.6 bits (122), Expect = 2e-06 Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 141 HLHAAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 176 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 V TR+YRAPE+ILG+G+ D+WS Sbjct: 177 ATGLLMTPYVVTRYYRAPEVILGMGYQANVDVWS 210
>MK08_XENLA (Q8QHK8) Mitogen-activated protein kinase 8 (EC 2.7.11.24)| (Stress-activated protein kinase JNK1) Length = 426 Score = 51.6 bits (122), Expect = 2e-06 Identities = 32/94 (34%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 176 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + V TR+YRAPE+ILG+G+ DIWS Sbjct: 177 GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWS 210
>SLK_CAVPO (O55092) STE20-like serine/threonine-protein kinase (EC 2.7.11.1)| (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) Length = 1231 Score = 37.7 bits (86), Expect(2) = 2e-06 Identities = 31/123 (25%), Positives = 51/123 (41%), Gaps = 10/123 (8%) Frame = +1 Query: 325 EIQIPLCPNSKMV*LSQPY--MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDE 498 E++ PL + V Q ++Y+H+ ++IH DLK NIL Sbjct: 122 ELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFT----------------- 164 Query: 499 IHCKCLPKSSAIKLIDFGSTAFDN---QEHNSIVSTRHYRAPEIIL-----GLGWSLPCD 654 IKL DFG +A + Q +S + T ++ APE+++ + D Sbjct: 165 -------LDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKAD 217 Query: 655 IWS 663 +WS Sbjct: 218 VWS 220 Score = 33.1 bits (74), Expect(2) = 2e-06 Identities = 17/51 (33%), Positives = 32/51 (62%), Gaps = 2/51 (3%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVV--RSIRKYRDAAMIEIDVL 304 ++ + ++G+G FG+V + ++ET A KV+ +S + D M+EID+L Sbjct: 34 WETIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELED-YMVEIDIL 83
>KS6A5_HUMAN (O75582) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL) Length = 802 Score = 51.2 bits (121), Expect = 3e-06 Identities = 31/95 (32%), Positives = 45/95 (47%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAF- 564 +MH++ ++H DLKPEN+L + D + IK+IDFG Sbjct: 534 HMHDVGVVHRDLKPENLLFT------------DENDNLE---------IKIIDFGFARLK 572 Query: 565 --DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 DNQ + T HY APE++ G+ CD+WS Sbjct: 573 PPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWS 607 Score = 31.2 bits (69), Expect = 2.9 Identities = 27/100 (27%), Positives = 42/100 (42%), Gaps = 6/100 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST- 558 + ++H+L +I+ D+K ENILL S+ + + L DFG + Sbjct: 165 LEHLHKLGIIYRDIKLENILLDSNGH------------------------VVLTDFGLSK 200 Query: 559 ---AFDNQEHNSIVSTRHYRAPEIILG--LGWSLPCDIWS 663 A + + S T Y AP+I+ G G D WS Sbjct: 201 EFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS 240
>CDK6_MOUSE (Q64261) Cell division protein kinase 6 (EC 2.7.11.22)| (Serine/threonine-protein kinase PLSTIRE) (CRK2) Length = 326 Score = 51.2 bits (121), Expect = 3e-06 Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++H R++H DLKP+NIL+ S S IKL DFG Sbjct: 133 LDFLHSHRVVHRDLKPQNILVTS------------------------SGQIKLADFGLAR 168 Query: 562 FDNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + S+V T YRAPE++L ++ P D+WS Sbjct: 169 IYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWS 204
>CDK6_HUMAN (Q00534) Cell division protein kinase 6 (EC 2.7.11.22)| (Serine/threonine-protein kinase PLSTIRE) Length = 326 Score = 51.2 bits (121), Expect = 3e-06 Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++H R++H DLKP+NIL+ S S IKL DFG Sbjct: 133 LDFLHSHRVVHRDLKPQNILVTS------------------------SGQIKLADFGLAR 168 Query: 562 FDNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + S+V T YRAPE++L ++ P D+WS Sbjct: 169 IYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWS 204
>KCC1_METAN (O14408) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| Length = 382 Score = 40.4 bits (93), Expect(2) = 3e-06 Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST-AF 564 Y+H+ ++H DLKPEN+L V+ + S + L DFG T Sbjct: 132 YLHDNDVVHRDLKPENLLYVTRD---------------------PDSDLVLADFGITKTL 170 Query: 565 DNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 D +E ++ + Y APE++ G P D+WS Sbjct: 171 DIKEETLTTMAGSFGYAAPEVMEQKGHGKPVDMWS 205 Score = 30.0 bits (66), Expect(2) = 3e-06 Identities = 19/79 (24%), Positives = 35/79 (44%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAENERYR 334 +YK +G GT+G V E + + I + ++++ E+D+L RL Sbjct: 22 KYKFGRTLGAGTYGVVREADGPSGKVAIKIILKKNVKGNEKMVYAELDMLQRLTHPH--- 78 Query: 335 SLCVQIQRWFDYRNHICII 391 V+ WF+ R+ I+ Sbjct: 79 --IVKFVDWFESRDKFYIV 95
>CDK7_CARAU (P51953) Cell division protein kinase 7 (EC 2.7.11.22) (EC| 2.7.11.23) (40 kDa protein kinase) (P40 MO15) (CDC2/CDK2,4-activating kinase) Length = 344 Score = 42.4 bits (98), Expect(2) = 3e-06 Identities = 30/98 (30%), Positives = 46/98 (46%), Gaps = 4/98 (4%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-ST 558 + YMH ++H DLKP N+L L ++ +KL DFG + Sbjct: 124 LEYMHNHWILHRDLKPNNLL------------------------LDENGVLKLADFGLAK 159 Query: 559 AF--DNQEHNSIVSTRHYRAPEIILGLG-WSLPCDIWS 663 AF N+ + V TR YRAPE++ G + + D+W+ Sbjct: 160 AFGSPNRVYTHQVVTRWYRAPELLFGARMYGVGVDMWA 197 Score = 28.1 bits (61), Expect(2) = 3e-06 Identities = 21/85 (24%), Positives = 39/85 (45%), Gaps = 6/85 (7%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRK------YRDAAMIEIDVLNRLAE 319 Y+ L +GEG F V + D+ T VAIK ++ + A+ EI +L L+ Sbjct: 12 YEKLDFLGEGQFATVYKARDKTTNTIVAIKKIKVGHRTEAKDGINRTALREIKLLQELSH 71 Query: 320 NERYRSLCVQIQRWFDYRNHICIIC 394 + + F ++++I ++C Sbjct: 72 PN-----IIGLLDAFGHKSNISLLC 91
>SGG_DROME (P18431) Protein kinase shaggy (EC 2.7.11.1) (Protein zeste-white| 3) Length = 1067 Score = 50.8 bits (120), Expect = 4e-06 Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST--A 561 Y+H L + H D+KP+N+LL P+++ +KL DFGS Sbjct: 722 YIHSLGICHRDIKPQNLLLD-----------------------PETAVLKLCDFGSAKQL 758 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + + S + +R+YRAPE+I G + ++ D+WS Sbjct: 759 LHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWS 793
>MK08_HUMAN (P45983) Mitogen-activated protein kinase 8 (EC 2.7.11.24)| (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46) Length = 427 Score = 50.8 bits (120), Expect = 4e-06 Identities = 31/94 (32%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 176 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + V TR+YRAPE+ILG+G+ D+WS Sbjct: 177 GTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWS 210
>MK08_RAT (P49185) Mitogen-activated protein kinase 8 (EC 2.7.11.24)| (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (SAPK gamma) (p54 gamma) Length = 411 Score = 50.8 bits (120), Expect = 4e-06 Identities = 31/94 (32%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 176 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + V TR+YRAPE+ILG+G+ D+WS Sbjct: 177 GTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWS 210
>MK08_MOUSE (Q91Y86) Mitogen-activated protein kinase 8 (EC 2.7.11.24)| (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) Length = 384 Score = 50.8 bits (120), Expect = 4e-06 Identities = 31/94 (32%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ S +K++DFG TA Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSD------------------------CTLKILDFGLARTA 176 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + V TR+YRAPE+ILG+G+ D+WS Sbjct: 177 GTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWS 210
>JNK_DROME (P92208) Stress-activated protein kinase JNK (EC 2.7.11.24) (dJNK)| (Protein basket) Length = 372 Score = 50.4 bits (119), Expect = 5e-06 Identities = 31/94 (32%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 ++H +IH DLKP NI++ + +K++DFG TA Sbjct: 139 HLHSAGIIHRDLKPSNIVVKAD------------------------CTLKILDFGLARTA 174 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 V TR+YRAPE+ILG+G++ DIWS Sbjct: 175 GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWS 208
>PMK2_CAEEL (Q8MXI4) Mitogen-activated protein kinase pmk-2 (EC 2.7.11.24) (p38| MAP kinase 2) (Stress-activated protein kinase pmk-2) Length = 419 Score = 50.4 bits (119), Expect = 5e-06 Identities = 33/95 (34%), Positives = 47/95 (49%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP NI + +KV S I S K++DFG Sbjct: 163 LKYIHSAGIIHRDLKPSNIAVNERCEVKVFLSFSQLSFLI-------LSFFKILDFGLAR 215 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V+TR YRAPEI+L + ++ D+WS Sbjct: 216 AQDAEMTGYVATRWYRAPEIMLNWMHYTQTVDVWS 250
>MKK2_YEAST (P32491) MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2)| Length = 506 Score = 50.4 bits (119), Expect = 5e-06 Identities = 34/95 (35%), Positives = 45/95 (47%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-ST 558 + Y+HE ++IH D+KP+NILL N + E IKL DFG S Sbjct: 330 LSYLHERKVIHRDIKPQNILL-------------NEKGE-----------IKLCDFGVSG 365 Query: 559 AFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 N + T Y APE I G +S+ CD+WS Sbjct: 366 EAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWS 400
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 45.1 bits (105), Expect(2) = 5e-06 Identities = 29/97 (29%), Positives = 41/97 (42%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + YMH ++H DLKPEN+L V ++S + + DFG Sbjct: 159 VEYMHSKNVVHRDLKPENVLYVDKS---------------------ENSPLVIADFGIAK 197 Query: 562 FDNQEHNSI---VSTRHYRAPEIILGLGWSLPCDIWS 663 E + I + Y APE++ G PCDIWS Sbjct: 198 QLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWS 234 Score = 24.6 bits (52), Expect(2) = 5e-06 Identities = 18/77 (23%), Positives = 34/77 (44%), Gaps = 5/77 (6%) Frame = +2 Query: 176 MGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMI-----EIDVLNRLAENERYRSL 340 +G G+FG V + T E VAIK++ + + E+ +L +L+ Sbjct: 53 LGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLSHPN----- 107 Query: 341 CVQIQRWFDYRNHICII 391 V + WF+ ++ I+ Sbjct: 108 IVSFKDWFESKDKFYIV 124
>NRC2_NEUCR (O42626) Serine/threonine-protein kinase nrc-2 (EC 2.7.11.1)| (Nonrepressible conidiation protein 2) Length = 623 Score = 49.7 bits (117), Expect = 8e-06 Identities = 35/101 (34%), Positives = 49/101 (48%), Gaps = 7/101 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDE-------IHCKCLPKSSAIKL 540 + Y+H + I+ DLKPENILL S +I + + Q + I K +S++ Sbjct: 355 LEYLHLMGFIYRDLKPENILLHQSGHIMLSDFDLSKQSDPGGKPTMIIGKNGTSTSSLPT 414 Query: 541 IDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ID S N NS V T Y APE+I G G + D W+ Sbjct: 415 IDTKS-CIANFRTNSFVGTEEYIAPEVIKGSGHTSAVDWWT 454
>KAD5_SCHPO (Q09831) Probable serine/threonine-protein kinase C4G8.05 (EC| 2.7.11.1) Length = 566 Score = 49.7 bits (117), Expect = 8e-06 Identities = 33/101 (32%), Positives = 48/101 (47%), Gaps = 7/101 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKV-------PSSKKNSQDEIHCKCLPKSSAIKL 540 + Y+H + I+ DLKPENILL S +I + S+ + I + P + Sbjct: 308 LEYLHLMGFIYRDLKPENILLHESGHIMLSDFDLSKQSNSAGAPTVIQARNAPSAQNAYA 367 Query: 541 IDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +D S D + NS V T Y APE+I G G + D W+ Sbjct: 368 LDTKSCIADFRT-NSFVGTEEYIAPEVIKGCGHTSAVDWWT 407
>KS6A5_PONPY (Q5R4K3) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 802 Score = 49.7 bits (117), Expect = 8e-06 Identities = 31/95 (32%), Positives = 45/95 (47%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAF- 564 +MH++ ++H DLKPEN+L + D + IK+IDFG Sbjct: 534 HMHDVGVVHRDLKPENLLFT------------DENDNLE---------IKIIDFGFARPK 572 Query: 565 --DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 DNQ + T HY APE++ G+ CD+WS Sbjct: 573 PPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWS 607 Score = 31.6 bits (70), Expect = 2.2 Identities = 27/100 (27%), Positives = 42/100 (42%), Gaps = 6/100 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST- 558 + ++H+L +I+ D+K ENILL S+ + + L DFG + Sbjct: 165 LEHLHKLGIIYRDIKLENILLDSNGH------------------------VMLTDFGLSK 200 Query: 559 ---AFDNQEHNSIVSTRHYRAPEIILG--LGWSLPCDIWS 663 A + + S T Y AP+I+ G G D WS Sbjct: 201 EFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS 240
>FUS3_YEAST (P16892) Mitogen-activated protein kinase FUS3 (EC 2.7.11.24) (MAP| kinase FUS3) Length = 353 Score = 37.7 bits (86), Expect(2) = 9e-06 Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 1/92 (1%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 +H +IH DLKP N+L+ S+ +KV D + + +S+A D Sbjct: 128 LHGSNVIHRDLKPSNLLINSNCDLKV-------CDFGLARIIDESAA----DNSEPTGQQ 176 Query: 571 QEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 V+TR YRAPE++L +S D+WS Sbjct: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWS 208 Score = 31.2 bits (69), Expect(2) = 9e-06 Identities = 22/85 (25%), Positives = 37/85 (43%), Gaps = 2/85 (2%) Frame = +2 Query: 143 NLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRK--YRDAAMIEIDVLNRLA 316 N++ +++ S +GEG +G V + T E VAIK + K + + EI +L Sbjct: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 Query: 317 ENERYRSLCVQIQRWFDYRNHICII 391 +Q F+ N + II Sbjct: 68 HENIITIFNIQRPDSFENFNEVYII 92
>KCC1_EMENI (Q00771) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CMPK) Length = 414 Score = 42.7 bits (99), Expect(2) = 1e-05 Identities = 28/97 (28%), Positives = 44/97 (45%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-ST 558 ++Y+H+ ++H DLKPEN+L ++ + S + L DFG + Sbjct: 130 VNYLHQRNIVHRDLKPENLLYLTRDL---------------------DSQLVLADFGIAK 168 Query: 559 AFDNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 DN S+ + Y APE++L G DIWS Sbjct: 169 MLDNPAEVLTSMAGSFGYAAPEVMLKQGHGKAVDIWS 205 Score = 25.8 bits (55), Expect(2) = 1e-05 Identities = 19/78 (24%), Positives = 33/78 (42%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAENERYRS 337 Y+ +G GT+G V E + V I + R++R E+D+L +L Sbjct: 23 YRFGRTLGAGTYGIVREADCSSGKVAVKIILKRNVRGNERMVYDELDLLQKLNHPH---- 78 Query: 338 LCVQIQRWFDYRNHICII 391 V WF+ ++ I+ Sbjct: 79 -IVHFVDWFESKDKFYIV 95
>KPCD2_HUMAN (Q9BZL6) Serine/threonine-protein kinase D2 (EC 2.7.11.13)| (nPKC-D2) Length = 878 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/96 (29%), Positives = 45/96 (46%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++H ++H DLKPEN+LL S++ +KL DFG Sbjct: 662 LRHLHFKNIVHCDLKPENVLLASAD---------------------PFPQVKLCDFGFAR 700 Query: 562 FDNQE--HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ S+V T Y APE++L G++ D+WS Sbjct: 701 IIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWS 736
>JNK_SUBDO (Q966Y3) Stress-activated protein kinase JNK (EC 2.7.11.24)| Length = 361 Score = 48.9 bits (115), Expect = 1e-05 Identities = 29/94 (30%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 ++H +IH DLKP NI++ + ++K++DFG Sbjct: 137 HLHSAGIIHRDLKPSNIVV------------------------KEDCSLKILDFGLARTA 172 Query: 568 NQEHNSI--VSTRHYRAPEIILGLGWSLPCDIWS 663 +Q N V TR+YRAPE+I+G+ + DIWS Sbjct: 173 DQTFNMTPYVVTRYYRAPEVIVGMKYKENVDIWS 206
>DCAK1_HUMAN (O15075) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 740 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/92 (30%), Positives = 42/92 (45%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 Y+H L ++H D+KPEN+L+ + S ++KL DFG Sbjct: 501 YLHSLNIVHRDIKPENLLVYEHQ--------------------DGSKSLKLGDFGLATIV 540 Query: 568 NQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + ++ T Y APEII G+ L DIW+ Sbjct: 541 DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWA 572 Score = 39.3 bits (90), Expect = 0.011 Identities = 20/64 (31%), Positives = 34/64 (53%), Gaps = 2/64 (3%) Frame = +2 Query: 128 FDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMI--EIDV 301 F + +T RYK+ +G+G F V EC +R T A+K+++ + MI E+ + Sbjct: 380 FQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSI 439 Query: 302 LNRL 313 L R+ Sbjct: 440 LRRV 443
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 48.9 bits (115), Expect = 1e-05 Identities = 27/94 (28%), Positives = 43/94 (45%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H L ++H D+KPEN+L+ C+ + ++KL DFG Sbjct: 502 LRYLHSLSIVHRDIKPENLLV--------------------CEYPDGTKSLKLGDFGLAT 541 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ T Y APEII G+ L D+W+ Sbjct: 542 VVEGPLYTVCGTPTYVAPEIIAETGYGLKVDVWA 575 Score = 32.3 bits (72), Expect = 1.3 Identities = 17/52 (32%), Positives = 28/52 (53%) Frame = +2 Query: 146 LTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDV 301 L +Y+I +G+G F V EC DR T + A+K++ + +IE +V Sbjct: 389 LLEKYRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGKEHLIENEV 440
>DCAK1_MOUSE (Q9JLM8) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 756 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/92 (30%), Positives = 42/92 (45%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 Y+H L ++H D+KPEN+L+ + S ++KL DFG Sbjct: 517 YLHSLNIVHRDIKPENLLVYEHQ--------------------DGSKSLKLGDFGLATIV 556 Query: 568 NQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + ++ T Y APEII G+ L DIW+ Sbjct: 557 DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWA 588 Score = 43.5 bits (101), Expect = 6e-04 Identities = 28/95 (29%), Positives = 46/95 (48%), Gaps = 2/95 (2%) Frame = +2 Query: 35 GAGDPPPEREVVARGGASPPWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECW 214 G GD R + RG WR ++ + F + +T RYK+ +G+G F V EC Sbjct: 372 GEGDELGRRHSLQRG-----WRREESEEG--FQIPATITERYKVGRTIGDGNFAVVKECI 424 Query: 215 DRETREYVAIKVVRSIRKYRDAAMI--EIDVLNRL 313 +R T A+K+++ + MI E+ +L R+ Sbjct: 425 ERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRV 459
>DCAK1_RAT (O08875) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) Length = 433 Score = 48.9 bits (115), Expect = 1e-05 Identities = 28/92 (30%), Positives = 42/92 (45%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 Y+H L ++H D+KPEN+L+ + S ++KL DFG Sbjct: 194 YLHSLNIVHRDIKPENLLVYEHQ--------------------DGSKSLKLGDFGLATIV 233 Query: 568 NQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + ++ T Y APEII G+ L DIW+ Sbjct: 234 DGPLYTVCGTPTYVAPEIIAETGYGLKVDIWA 265 Score = 39.7 bits (91), Expect = 0.008 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 2/76 (2%) Frame = +2 Query: 92 PWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKY 271 P ++ +G F + +T RYK+ +G+G F V EC +R T A+K+++ + Sbjct: 64 PGEEESDEG---FQIPATITERYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCR 120 Query: 272 RDAAMI--EIDVLNRL 313 MI E+ +L R+ Sbjct: 121 GKEHMIQNEVSILRRV 136
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 42.7 bits (99), Expect(2) = 1e-05 Identities = 29/93 (31%), Positives = 42/93 (45%), Gaps = 1/93 (1%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-STAF 564 Y+H +IH D+K NIL K IKL DFG +T Sbjct: 121 YLHNQGVIHRDIKGANILTT------------------------KDGTIKLADFGVATKI 156 Query: 565 DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + E +S+V + ++ APE+I +G + DIWS Sbjct: 157 NALEDHSVVGSPYWMAPEVIELVGATTASDIWS 189 Score = 25.4 bits (54), Expect(2) = 1e-05 Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 12/88 (13%) Frame = +2 Query: 176 MGEGTFGRVLECWDRETREYVAIKVVRSIRKYR-DAAMI--EIDVLNRLAENE--RYR-- 334 +G+G FG V + + E VA+K V+ + + D ++I EID+L L +YR Sbjct: 15 LGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVKYRGS 74 Query: 335 -----SLCVQIQRWFDYRNHICIICTNY 403 SLC+ ++ + + IC N+ Sbjct: 75 YQTNDSLCIILE--YCENGSLRSICKNF 100
>MK14B_CYPCA (Q9I958) Mitogen-activated protein kinase 14b (EC 2.7.11.24)| (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (cp38b) Length = 361 Score = 48.5 bits (114), Expect = 2e-05 Identities = 28/95 (29%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + + +K++DFG Sbjct: 139 LKYIHSADIIHRDLKPSNL------------------------AVNEDCELKILDFGLAR 174 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V+TR YRAPEI+L + +++ DIWS Sbjct: 175 LTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWS 209
>MK14B_BRARE (Q9DGE1) Mitogen-activated protein kinase 14b (EC 2.7.11.24)| (Mitogen-activated protein kinase p38b) (MAP kinase p38b) (zp38b) Length = 348 Score = 48.5 bits (114), Expect = 2e-05 Identities = 28/95 (29%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + + +K++DFG Sbjct: 139 LKYIHSADIIHRDLKPSNL------------------------AVNEDCELKILDFGLAR 174 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V+TR YRAPEI+L + +++ DIWS Sbjct: 175 LTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWS 209 Score = 29.6 bits (65), Expect = 8.5 Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 8/54 (14%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIK--------VVRSIRKYRDAAMIE 292 RY+ LS +G G +G V+ +D + VA+K ++ + R YR+ +++ Sbjct: 24 RYQNLSPVGSGAYGSVMSAFDGKAGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 77
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 48.5 bits (114), Expect = 2e-05 Identities = 28/94 (29%), Positives = 43/94 (45%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H L ++H D+KPEN+L+ C+ + ++KL DFG Sbjct: 503 LRYLHGLSIVHRDIKPENLLV--------------------CEYPDGTKSLKLGDFGLAT 542 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ T Y APEII G+ L DIW+ Sbjct: 543 VVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWA 576 Score = 34.3 bits (77), Expect = 0.35 Identities = 18/52 (34%), Positives = 28/52 (53%) Frame = +2 Query: 146 LTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDV 301 L +YKI +G+G F V EC DR T + A+K++ + +IE +V Sbjct: 390 LLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEV 441
>HOG1_ASHGO (Q750A9) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 48.5 bits (114), Expect = 2e-05 Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP NIL+ ++ +K+ DFG Sbjct: 132 LKYVHSAGVIHRDLKPSNILI------------------------NENCDLKICDFGLAR 167 Query: 562 FDNQEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + + VSTR+YRAPEI+L +++ DIWS Sbjct: 168 IQDPQMTGYVSTRYYRAPEIMLTWQKYNVEVDIWS 202 Score = 30.8 bits (68), Expect = 3.8 Identities = 20/64 (31%), Positives = 31/64 (48%), Gaps = 8/64 (12%) Frame = +2 Query: 125 VFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIK--------VVRSIRKYRDA 280 +F +T RY L+ +G G FG V D T++ VAIK V + R YR+ Sbjct: 12 IFGTVFEITNRYADLNPVGMGAFGLVCSAVDTYTQQPVAIKKIMKPFSTAVLAKRTYREL 71 Query: 281 AMIE 292 +++ Sbjct: 72 KLLK 75
>KC47_ORYSA (P29620) CDC2+/CDC28-related protein kinase R2 (EC 2.7.11.22)| Length = 424 Score = 34.3 bits (77), Expect(2) = 2e-05 Identities = 25/83 (30%), Positives = 44/83 (53%), Gaps = 4/83 (4%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRD----AAMIEIDVLNRLAEN 322 RY +GEGT+G V + D +T VAIK +R + KY++ A+ EI +L L + Sbjct: 18 RYLKREVLGEGTYGVVFKAVDTKTGNTVAIKKIR-LGKYKEGVNFTALREIKLLKELKD- 75 Query: 323 ERYRSLCVQIQRWFDYRNHICII 391 S +++ F Y+ ++ ++ Sbjct: 76 ----SNIIELIDAFPYKGNLHLV 94 Score = 33.5 bits (75), Expect(2) = 2e-05 Identities = 26/96 (27%), Positives = 41/96 (42%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-STAF 564 + H+ ++H D+KP N+L+ + +KL DFG + F Sbjct: 131 FCHKKWVLHRDMKPNNLLIGA------------------------DGQLKLADFGLARIF 166 Query: 565 DNQEHNSI--VSTRHYRAPEIILGL-GWSLPCDIWS 663 + E N V R YRAPE++ G + DIW+ Sbjct: 167 GSPERNFTHQVFARWYRAPELLFGTKQYGSAVDIWA 202
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 41.6 bits (96), Expect(2) = 2e-05 Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 ++Y+H + ++H DLKPEN+L SQDE S I + DFG + Sbjct: 132 VYYLHRMGIVHRDLKPENLLYY-------------SQDE--------ESKIMISDFGLSK 170 Query: 562 FDNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + ++ T Y APE++ +S D WS Sbjct: 171 MEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWS 206 Score = 26.2 bits (56), Expect(2) = 2e-05 Identities = 21/107 (19%), Positives = 45/107 (42%), Gaps = 2/107 (1%) Frame = +2 Query: 77 GGASPPWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVV- 253 G +S W+ D +F+ E L G G F V+ ++ T + A+K + Sbjct: 6 GESSSSWKKQAEDIKKIFEFKETL----------GTGAFSEVVLAEEKATGKLFAVKCIP 55 Query: 254 -RSIRKYRDAAMIEIDVLNRLAENERYRSLCVQIQRWFDYRNHICII 391 ++++ + EI VL ++ V ++ ++ NH+ ++ Sbjct: 56 KKALKGKESSIENEIAVLRKIKHEN-----IVALEDIYESPNHLYLV 97
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 41.6 bits (96), Expect(2) = 2e-05 Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 ++Y+H + ++H DLKPEN+L SQDE S I + DFG + Sbjct: 132 VYYLHRMGIVHRDLKPENLLYY-------------SQDE--------ESKIMISDFGLSK 170 Query: 562 FDNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + ++ T Y APE++ +S D WS Sbjct: 171 MEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWS 206 Score = 26.2 bits (56), Expect(2) = 2e-05 Identities = 21/107 (19%), Positives = 45/107 (42%), Gaps = 2/107 (1%) Frame = +2 Query: 77 GGASPPWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVV- 253 G +S W+ D +F+ E L G G F V+ ++ T + A+K + Sbjct: 6 GESSSSWKKQAEDIKKIFEFKETL----------GTGAFSEVVLAEEKATGKLFAVKCIP 55 Query: 254 -RSIRKYRDAAMIEIDVLNRLAENERYRSLCVQIQRWFDYRNHICII 391 ++++ + EI VL ++ V ++ ++ NH+ ++ Sbjct: 56 KKALKGKESSIENEIAVLRKIKHEN-----IVALEDIYESPNHLYLV 97
>KIN82_YEAST (P25341) Probable serine/threonine-protein kinase KIN82 (EC| 2.7.11.1) Length = 720 Score = 48.1 bits (113), Expect = 2e-05 Identities = 33/94 (35%), Positives = 43/94 (45%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H L I+ DLKPENILL S ++ + + Q K K S S Sbjct: 437 LEYLHLLGFIYRDLKPENILLHQSGHVMLSDFDLSIQATGSKKPTMKDSTYLDTKICSDG 496 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 F NS V T Y APE+I G G + D W+ Sbjct: 497 F---RTNSFVGTEEYLAPEVIRGNGHTAAVDWWT 527
>HOG1_ZYGRO (O93982) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 380 Score = 48.1 bits (113), Expect = 2e-05 Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP NIL+ ++ +K+ DFG Sbjct: 132 LKYVHSAGVIHRDLKPSNILI------------------------NENCDLKICDFGLAR 167 Query: 562 FDNQEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + + VSTR+YRAPEI+L + + DIWS Sbjct: 168 IQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWS 202
>SKH1_SCHPO (Q9Y884) MAP kinase kinase skh1/pek1 (EC 2.7.12.2)| Length = 363 Score = 48.1 bits (113), Expect = 2e-05 Identities = 30/95 (31%), Positives = 42/95 (44%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-ST 558 + Y+H+ ++IH D+KP NILL S +KL DFG S Sbjct: 194 LSYLHDRKIIHRDIKPSNILLTS------------------------KGQVKLCDFGVSG 229 Query: 559 AFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 N + T +Y APE I G +++ DIWS Sbjct: 230 ELVNSLAGTFTGTSYYMAPERISGGSYTISSDIWS 264
>MK14A_CYPCA (Q90336) Mitogen-activated protein kinase 14a (EC 2.7.11.24)| (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (cp38a) Length = 361 Score = 48.1 bits (113), Expect = 2e-05 Identities = 28/95 (29%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + + +K++DFG Sbjct: 139 LKYIHSADIIHRDLKPSNL------------------------AVNEDCELKILDFGLAR 174 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V+TR YRAPEI+L + +++ DIWS Sbjct: 175 HTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWS 209 Score = 31.6 bits (70), Expect = 2.2 Identities = 16/54 (29%), Positives = 29/54 (53%), Gaps = 8/54 (14%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIK--------VVRSIRKYRDAAMIE 292 RY+ LS +G G +G V +D +T VA+K ++ + R YR+ +++ Sbjct: 24 RYQNLSPVGSGAYGTVCSAYDEKTGLKVAVKKLSRPFQSIIHAKRTYRELRLLK 77
>ERKA_DROME (P40417) Mitogen-activated protein kinase ERK-A (EC 2.7.11.24)| (Extracellular-regulated kinase A) (Protein rolled) Length = 376 Score = 48.1 bits (113), Expect = 2e-05 Identities = 32/101 (31%), Positives = 46/101 (45%), Gaps = 7/101 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP N+L L K+ +K+ DFG Sbjct: 150 LKYIHSANVLHRDLKPSNLL------------------------LNKTCDLKICDFGLAR 185 Query: 562 FDNQEHN------SIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + EH+ V+TR YRAPEI+L G++ DIWS Sbjct: 186 IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS 226 Score = 31.6 bits (70), Expect = 2.2 Identities = 21/64 (32%), Positives = 33/64 (51%), Gaps = 2/64 (3%) Frame = +2 Query: 125 VFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI--RKYRDAAMIEID 298 +F++G RY L+ +GEG +G V+ D T + VAIK + + Y + EI Sbjct: 31 IFEVGP----RYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREIT 86 Query: 299 VLNR 310 +L R Sbjct: 87 ILTR 90
>HOG1_YEAST (P32485) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) (Osmosensing protein HOG1) Length = 435 Score = 48.1 bits (113), Expect = 2e-05 Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP NIL+ ++ +K+ DFG Sbjct: 132 LKYVHSAGVIHRDLKPSNILI------------------------NENCDLKICDFGLAR 167 Query: 562 FDNQEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + + VSTR+YRAPEI+L + + DIWS Sbjct: 168 IQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWS 202 Score = 30.4 bits (67), Expect = 5.0 Identities = 20/64 (31%), Positives = 30/64 (46%), Gaps = 8/64 (12%) Frame = +2 Query: 125 VFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIK--------VVRSIRKYRDA 280 +F +T RY L+ +G G FG V D T + VAIK V + R YR+ Sbjct: 12 IFGTVFEITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYREL 71 Query: 281 AMIE 292 +++ Sbjct: 72 KLLK 75
>GSK3H_DROME (P83101) Putative glycogen synthase kinase-3 homolog (EC 2.7.11.26)| (GSK-3) (Protein gasket) Length = 501 Score = 47.8 bits (112), Expect = 3e-05 Identities = 30/97 (30%), Positives = 46/97 (47%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST- 558 M Y+H L H D+KP+N+LL S ++ +KL DFGS Sbjct: 146 MGYLHSLGFCHRDIKPQNMLLDS-----------------------ETGVLKLCDFGSAK 182 Query: 559 -AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + + S + +R+YRAPE+I G ++ D+WS Sbjct: 183 QLISGEPNVSYICSRYYRAPELIFGSTDYTTKIDMWS 219
>MK14A_BRARE (Q9DGE2) Mitogen-activated protein kinase 14a (EC 2.7.11.24)| (Mitogen-activated protein kinase p38a) (MAP kinase p38a) (zp38a) Length = 361 Score = 47.8 bits (112), Expect = 3e-05 Identities = 28/95 (29%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + + +K++DFG Sbjct: 139 LKYIHSADIIHRDLKPSNL------------------------AVNEDCELKILDFGLAR 174 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V+TR YRAPEI+L + +++ DIWS Sbjct: 175 HTDDEMTGYVATRWYRAPEIMLNWMHYNVTVDIWS 209
>MOK_HUMAN (Q9UQ07) MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK| protein kinase) (Renal tumor antigen 1) (RAGE-1) Length = 419 Score = 47.8 bits (112), Expect = 3e-05 Identities = 34/107 (31%), Positives = 48/107 (44%), Gaps = 13/107 (12%) Frame = +1 Query: 382 MHYMHEL----------RLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSA 531 MHYM++L + H D+KPENIL+ K Sbjct: 106 MHYMYQLCKSLDHIHRNGIFHRDVKPENILI-------------------------KQDV 140 Query: 532 IKLIDFGS--TAFDNQEHNSIVSTRHYRAPEIILGLG-WSLPCDIWS 663 +KL DFGS + + Q + +STR YRAPE +L G ++ D+WS Sbjct: 141 LKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWS 187 Score = 29.6 bits (65), Expect = 8.5 Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 4/58 (6%) Frame = +2 Query: 152 RRYKILSKMGEGTFGRVLECWDRETREYVAIKVVR----SIRKYRDAAMIEIDVLNRL 313 + YK + K+GEGTF V++ Y A K ++ SI + + + EI L RL Sbjct: 2 KNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNN--LREIQALRRL 57
>HOG1_CANGA (Q6FIU2) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 47.8 bits (112), Expect = 3e-05 Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP NIL+ ++ +K+ DFG Sbjct: 132 LKYVHSAGVVHRDLKPSNILI------------------------NENCDLKICDFGLAR 167 Query: 562 FDNQEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + + VSTR+YRAPEI+L + + DIWS Sbjct: 168 IQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWS 202 Score = 31.6 bits (70), Expect = 2.2 Identities = 20/64 (31%), Positives = 30/64 (46%), Gaps = 8/64 (12%) Frame = +2 Query: 125 VFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIK--------VVRSIRKYRDA 280 +F +T RY L+ +G G FG V D T + VAIK V + R YR+ Sbjct: 12 IFGTVFEITNRYSDLNPVGMGAFGLVCSATDTLTNQQVAIKKIMKPFATAVLAKRTYREL 71 Query: 281 AMIE 292 +++ Sbjct: 72 KLLK 75
>MOK_MOUSE (Q9WVS4) MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK| protein kinase) Length = 420 Score = 47.8 bits (112), Expect = 3e-05 Identities = 31/97 (31%), Positives = 45/97 (46%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGS-- 555 + +MH + H D+KPENIL+ K +KL DFGS Sbjct: 116 LDHMHRNGIFHRDVKPENILV-------------------------KQDVLKLGDFGSCR 150 Query: 556 TAFDNQEHNSIVSTRHYRAPEIILGLG-WSLPCDIWS 663 + + Q + +STR YRAPE +L G ++ D+WS Sbjct: 151 SVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWS 187 Score = 29.6 bits (65), Expect = 8.5 Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 4/58 (6%) Frame = +2 Query: 152 RRYKILSKMGEGTFGRVLECWDRETREYVAIKVVR----SIRKYRDAAMIEIDVLNRL 313 + YK + K+GEGTF V++ Y A K ++ SI + ++ EI L RL Sbjct: 2 KNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVN--SLREIQALRRL 57
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)| Length = 508 Score = 47.4 bits (111), Expect = 4e-05 Identities = 32/95 (33%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-ST 558 + Y+HE ++IH D+KP+NILL +N Q +KL DFG S Sbjct: 337 LSYLHEKKVIHRDIKPQNILL-----------NENGQ-------------VKLCDFGVSG 372 Query: 559 AFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 N + T Y APE I G +S+ D+WS Sbjct: 373 EAVNSLATTFTGTSFYMAPERIQGQPYSVTSDVWS 407
>KCC2B_RAT (P08413) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 47.4 bits (111), Expect = 4e-05 Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 + H++ ++H DLKPEN+LL S KC K +A+KL DFG Sbjct: 126 HCHQMGVVHRDLKPENLLLAS-------------------KC--KGAAVKLADFGLAIEV 164 Query: 559 AFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 D Q T Y +PE++ + P DIW+ Sbjct: 165 QGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWA 199
>KCC2B_MOUSE (P28652) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 47.4 bits (111), Expect = 4e-05 Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 + H++ ++H DLKPEN+LL S KC K +A+KL DFG Sbjct: 126 HCHQMGVVHRDLKPENLLLAS-------------------KC--KGAAVKLADFGLAIEV 164 Query: 559 AFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 D Q T Y +PE++ + P DIW+ Sbjct: 165 QGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWA 199
>DAPK3_HUMAN (O43293) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 454 Score = 47.4 bits (111), Expect = 4e-05 Identities = 33/96 (34%), Positives = 44/96 (45%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--S 555 +HY+H R+ H DLKPENI+L+ VP+ + IKLIDFG Sbjct: 127 VHYLHSKRIAHFDLKPENIMLLDK---NVPNPR-----------------IKLIDFGIAH 166 Query: 556 TAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 E +I T + APEI+ L D+WS Sbjct: 167 KIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWS 202
>TRIO_HUMAN (O75962) Triple functional domain protein (PTPRF-interacting protein)| Length = 3038 Score = 47.4 bits (111), Expect = 4e-05 Identities = 34/96 (35%), Positives = 43/96 (44%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H R+ H DLKPENIL+ DE K IKL DFG Sbjct: 2844 VRYLHNCRIAHLDLKPENILV----------------DESLAK-----PTIKLADFGDAV 2882 Query: 562 FDNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 N + + ++ + APEIILG SL D WS Sbjct: 2883 QLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWS 2918
>KCC2B_HUMAN (Q13554) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 664 Score = 47.4 bits (111), Expect = 4e-05 Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 + H++ ++H DLKPEN+LL S KC K +A+KL DFG Sbjct: 126 HCHQMGVVHRDLKPENLLLAS-------------------KC--KGAAVKLADFGLAIEV 164 Query: 559 AFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 D Q T Y +PE++ + P DIW+ Sbjct: 165 QGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWA 199
>MK14_XENLA (P47812) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated Mitogen-activated protein kinase 2) (MAP kinase 2) (MPK2) Length = 361 Score = 47.4 bits (111), Expect = 4e-05 Identities = 28/95 (29%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + + +K++DFG Sbjct: 139 LKYIHSAGIIHRDLKPSNL------------------------AVNEDCELKILDFGLAR 174 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 ++E V+TR YRAPEI+L + ++ DIWS Sbjct: 175 HTDEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWS 209
>CDKL3_MOUSE (Q8BLF2) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| Length = 595 Score = 47.4 bits (111), Expect = 4e-05 Identities = 31/98 (31%), Positives = 44/98 (44%), Gaps = 4/98 (4%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--- 552 + Y+H +IH D+KPENIL + +S KL DFG Sbjct: 113 IEYLHNNNIIHRDIKPENIL------------------------VSQSGITKLCDFGFAR 148 Query: 553 STAFDNQEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + A + V+TR YRAPE++L + P DIW+ Sbjct: 149 TLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWA 186 Score = 35.8 bits (81), Expect = 0.12 Identities = 14/31 (45%), Positives = 23/31 (74%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKV 250 Y+ L K+GEG++G V++C ++T VAIK+ Sbjct: 4 YETLGKVGEGSYGTVMKCKHKDTGRIVAIKI 34
>STY1_SCHPO (Q09892) Mitogen-activated protein kinase sty1 (EC 2.7.11.24) (MAP| kinase sty1) (MAP kinase spc1) Length = 349 Score = 47.0 bits (110), Expect = 5e-05 Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++H +IH DLKP NIL+ ++ +K+ DFG Sbjct: 129 LKFVHSAGVIHRDLKPSNILI------------------------NENCDLKICDFGLAR 164 Query: 562 FDNQEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + + VSTR+YRAPEI+L +++ DIWS Sbjct: 165 IQDPQMTGYVSTRYYRAPEIMLTWQKYNVEVDIWS 199
>CDC22_MEDSA (Q05006) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 294 Score = 47.0 bits (110), Expect = 5e-05 Identities = 33/96 (34%), Positives = 45/96 (46%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 Y H R++H DLKP+N+L+ S S+A+KL DFG + Sbjct: 117 YCHSHRVLHRDLKPQNLLIDRS-----------------------SNAVKLADFGLARAF 153 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + V T YRAPEI+LG +S P D+WS Sbjct: 154 GIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWS 189 Score = 35.4 bits (80), Expect = 0.15 Identities = 15/34 (44%), Positives = 24/34 (70%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVR 256 +Y+ + K+GEGT+G V + DR T E +A+K +R Sbjct: 3 QYEKVEKIGEGTYGVVYKARDRATNETIALKKIR 36
>KPCD1_HUMAN (Q15139) Serine/threonine-protein kinase D1 (EC 2.7.11.13)| (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 912 Score = 46.6 bits (109), Expect = 7e-05 Identities = 27/96 (28%), Positives = 44/96 (45%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++H ++H DLKPEN+LL S++ +KL DFG Sbjct: 694 LRHLHFKNIVHCDLKPENVLLASAD---------------------PFPQVKLCDFGFAR 732 Query: 562 FDNQE--HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ S+V T Y APE++ G++ D+WS Sbjct: 733 IIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWS 768
>DAPK3_RAT (O88764) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 46.6 bits (109), Expect = 7e-05 Identities = 32/96 (33%), Positives = 41/96 (42%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--S 555 +HY+H R+ H DLKPENI+L+ S IKLIDFG Sbjct: 127 VHYLHSKRIAHFDLKPENIMLLDKH--------------------AASPRIKLIDFGIAH 166 Query: 556 TAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 E +I T + APEI+ L D+WS Sbjct: 167 RIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMWS 202
>DAPK3_MOUSE (O54784) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 46.6 bits (109), Expect = 7e-05 Identities = 32/96 (33%), Positives = 41/96 (42%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--S 555 +HY+H R+ H DLKPENI+L+ S IKLIDFG Sbjct: 127 VHYLHSKRIAHFDLKPENIMLLDKH--------------------AASPRIKLIDFGIAH 166 Query: 556 TAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 E +I T + APEI+ L D+WS Sbjct: 167 RIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMWS 202
>KPCD1_MOUSE (Q62101) Serine/threonine-protein kinase D1 (EC 2.7.11.13)| (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 918 Score = 46.6 bits (109), Expect = 7e-05 Identities = 27/96 (28%), Positives = 44/96 (45%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++H ++H DLKPEN+LL S++ +KL DFG Sbjct: 700 LRHLHFKNIVHCDLKPENVLLASAD---------------------PFPQVKLCDFGFAR 738 Query: 562 FDNQE--HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ S+V T Y APE++ G++ D+WS Sbjct: 739 IIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWS 774
>CDKL1_MOUSE (Q8CEQ0) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 46.6 bits (109), Expect = 7e-05 Identities = 30/98 (30%), Positives = 45/98 (45%), Gaps = 4/98 (4%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 +++ H+ IH D+KPENIL+ K SAIKL DFG Sbjct: 114 VNFCHKHNCIHRDVKPENILIT------------------------KQSAIKLCDFGFAR 149 Query: 562 F---DNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + V+TR YR+PE+++G + P D+W+ Sbjct: 150 LLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWA 187 Score = 35.0 bits (79), Expect = 0.20 Identities = 14/31 (45%), Positives = 24/31 (77%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIK 247 +Y+ + K+GEG++G V +C +R+T + VAIK Sbjct: 3 KYEKIGKIGEGSYGVVFKCRNRDTGQIVAIK 33
>CDKL3_HUMAN (Q8IVW4) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| (Serine/threonine protein kinase NKIAMRE) Length = 592 Score = 46.6 bits (109), Expect = 7e-05 Identities = 31/96 (32%), Positives = 43/96 (44%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 Y+H +IH D+KPENIL + +S KL DFG + Sbjct: 115 YLHSNNIIHRDIKPENIL------------------------VSQSGITKLCDFGFARTL 150 Query: 559 AFDNQEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 A + V+TR YRAPE++L + P DIW+ Sbjct: 151 AAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWA 186 Score = 37.0 bits (84), Expect = 0.053 Identities = 20/53 (37%), Positives = 31/53 (58%), Gaps = 2/53 (3%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVV--RSIRKYRDAAMIEIDVLNR 310 Y+ L K+GEG++G V++C + T + VAIK+ R + AM EI L + Sbjct: 4 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQ 56
>HOG1_CANAL (Q92207) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 377 Score = 46.6 bits (109), Expect = 7e-05 Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP NIL+ ++ +K+ DFG Sbjct: 132 LKYIHSAGVIHRDLKPSNILI------------------------NENCDLKICDFGLAR 167 Query: 562 FDNQEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + + VSTR+YRAPEI+L + D+WS Sbjct: 168 LQDPQMTGYVSTRYYRAPEIMLTWQKYDTEVDLWS 202 Score = 31.6 bits (70), Expect = 2.2 Identities = 17/43 (39%), Positives = 23/43 (53%) Frame = +2 Query: 125 VFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVV 253 +F +T RY L+ +G G FG V DR T + VA+K V Sbjct: 12 IFGTVFEITNRYTELNPVGMGAFGLVCSAVDRLTGQNVAVKKV 54
>MK14_RAT (P70618) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1) Length = 359 Score = 46.6 bits (109), Expect = 7e-05 Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + + +K++DFG Sbjct: 137 LKYIHSADIIHRDLKPSNL------------------------AVNEDCELKILDFGLAR 172 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V+TR YRAPEI+L + ++ DIWS Sbjct: 173 HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWS 207 Score = 31.6 bits (70), Expect = 2.2 Identities = 16/54 (29%), Positives = 29/54 (53%), Gaps = 8/54 (14%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIK--------VVRSIRKYRDAAMIE 292 RY+ LS +G G +G V +D +T VA+K ++ + R YR+ +++ Sbjct: 22 RYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLK 75
>MK14_PANTR (Q95NE7) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) Length = 359 Score = 46.6 bits (109), Expect = 7e-05 Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + + +K++DFG Sbjct: 137 LKYIHSADIIHRDLKPSNL------------------------AVNEDCELKILDFGLAR 172 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V+TR YRAPEI+L + ++ DIWS Sbjct: 173 HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWS 207 Score = 30.4 bits (67), Expect = 5.0 Identities = 16/54 (29%), Positives = 29/54 (53%), Gaps = 8/54 (14%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIK--------VVRSIRKYRDAAMIE 292 RY+ LS +G G +G V +D +T VA+K ++ + R YR+ +++ Sbjct: 22 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 75
>MK14_MOUSE (P47811) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1) Length = 359 Score = 46.6 bits (109), Expect = 7e-05 Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + + +K++DFG Sbjct: 137 LKYIHSADIIHRDLKPSNL------------------------AVNEDCELKILDFGLAR 172 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V+TR YRAPEI+L + ++ DIWS Sbjct: 173 HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWS 207 Score = 31.6 bits (70), Expect = 2.2 Identities = 16/54 (29%), Positives = 29/54 (53%), Gaps = 8/54 (14%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIK--------VVRSIRKYRDAAMIE 292 RY+ LS +G G +G V +D +T VA+K ++ + R YR+ +++ Sbjct: 22 RYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLK 75
>MK14_HUMAN (Q16539) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting prote Length = 359 Score = 46.6 bits (109), Expect = 7e-05 Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + + +K++DFG Sbjct: 137 LKYIHSADIIHRDLKPSNL------------------------AVNEDCELKILDFGLAR 172 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V+TR YRAPEI+L + ++ DIWS Sbjct: 173 HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWS 207 Score = 30.4 bits (67), Expect = 5.0 Identities = 16/54 (29%), Positives = 29/54 (53%), Gaps = 8/54 (14%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIK--------VVRSIRKYRDAAMIE 292 RY+ LS +G G +G V +D +T VA+K ++ + R YR+ +++ Sbjct: 22 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 75
>MK14_CANFA (O02812) Mitogen-activated protein kinase 14 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) Length = 359 Score = 46.6 bits (109), Expect = 7e-05 Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + + +K++DFG Sbjct: 137 LKYIHSADIIHRDLKPSNL------------------------AVNEDCELKILDFGLAR 172 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V+TR YRAPEI+L + ++ DIWS Sbjct: 173 HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWS 207 Score = 30.4 bits (67), Expect = 5.0 Identities = 16/54 (29%), Positives = 29/54 (53%), Gaps = 8/54 (14%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIK--------VVRSIRKYRDAAMIE 292 RY+ LS +G G +G V +D +T VA+K ++ + R YR+ +++ Sbjct: 22 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 75
>HOG1_DEBHA (Q9UV50) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 387 Score = 46.6 bits (109), Expect = 7e-05 Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP NIL+ ++ +K+ DFG Sbjct: 132 LKYVHSAGVIHRDLKPSNILI------------------------NENCDLKICDFGLAR 167 Query: 562 FDNQEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + + VSTR+YRAPEI+L + D+WS Sbjct: 168 IQDPQMTGYVSTRYYRAPEIMLTWQKYDTEVDLWS 202 Score = 30.0 bits (66), Expect = 6.5 Identities = 15/43 (34%), Positives = 23/43 (53%) Frame = +2 Query: 125 VFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVV 253 +F +T RY L+ +G G FG V D+ T + VA+K + Sbjct: 12 IFGTVFEITNRYTDLNPVGMGAFGLVCSAIDKLTGQNVAVKKI 54
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 46.6 bits (109), Expect = 7e-05 Identities = 30/94 (31%), Positives = 49/94 (52%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 Y+H+ ++H D+KPENILL KNS IK++DFG ++F Sbjct: 179 YLHKHNIVHRDIKPENILL----------ENKNS-----------LLNIKIVDFGLSSFF 217 Query: 568 NQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++++ + T +Y APE +L ++ CD+WS Sbjct: 218 SKDYKLRDRLGTAYYIAPE-VLKKKYNEKCDVWS 250 Score = 29.6 bits (65), Expect = 8.5 Identities = 21/80 (26%), Positives = 33/80 (41%), Gaps = 14/80 (17%) Frame = +2 Query: 116 GHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVV-------------- 253 G YV + Y + K+G G +G VL C ++ AIKV+ Sbjct: 42 GMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYNDDN 101 Query: 254 RSIRKYRDAAMIEIDVLNRL 313 ++I K+ + EI +L L Sbjct: 102 KNIEKFHEEIYNEISLLKSL 121
>CDKL3_RAT (Q9JM01) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| (Serine/threonine protein kinase NKIATRE) Length = 593 Score = 46.6 bits (109), Expect = 7e-05 Identities = 31/98 (31%), Positives = 44/98 (44%), Gaps = 4/98 (4%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--- 552 + Y+H +IH D+KPENIL + +S KL DFG Sbjct: 113 IEYLHNNNIIHRDIKPENIL------------------------VSQSGITKLCDFGFAR 148 Query: 553 STAFDNQEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + A + V+TR YRAPE++L + P DIW+ Sbjct: 149 TLAAPGDVYTDYVATRWYRAPELVLKDTTYGKPVDIWA 186 Score = 35.8 bits (81), Expect = 0.12 Identities = 14/31 (45%), Positives = 23/31 (74%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKV 250 Y+ L K+GEG++G V++C ++T VAIK+ Sbjct: 4 YETLGKVGEGSYGTVMKCKHKDTGRIVAIKI 34
>CDKL3_MACFA (Q4R8T9) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| Length = 590 Score = 46.6 bits (109), Expect = 7e-05 Identities = 31/96 (32%), Positives = 43/96 (44%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 Y+H +IH D+KPENIL + +S KL DFG + Sbjct: 115 YLHSNNIIHRDIKPENIL------------------------VSQSGITKLCDFGFARTL 150 Query: 559 AFDNQEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 A + V+TR YRAPE++L + P DIW+ Sbjct: 151 AAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWA 186 Score = 37.0 bits (84), Expect = 0.053 Identities = 20/53 (37%), Positives = 31/53 (58%), Gaps = 2/53 (3%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVV--RSIRKYRDAAMIEIDVLNR 310 Y+ L K+GEG++G V++C + T + VAIK+ R + AM EI L + Sbjct: 4 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQ 56
>KPSH1_PINFU (Q4KTY1) Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)| Length = 415 Score = 34.7 bits (78), Expect(2) = 7e-05 Identities = 26/95 (27%), Positives = 37/95 (38%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 Y+H L + H DLKPEN+L + S I + DFG ++ Sbjct: 188 YLHGLGITHRDLKPENLLYYHPGH---------------------DSKIMITDFGLSSTR 226 Query: 568 NQEHN---SIVSTRHYRAPEIILGLGWSLPCDIWS 663 N + T Y APEII + D+W+ Sbjct: 227 KGPENFMRTTCGTPEYIAPEIIARKPYMCQVDMWA 261 Score = 31.2 bits (69), Expect(2) = 7e-05 Identities = 25/115 (21%), Positives = 52/115 (45%) Frame = +2 Query: 47 PPPEREVVARGGASPPWRDDDRDGHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRET 226 PPPE + R + + Y +T +Y I + +G G F +V+ R T Sbjct: 54 PPPEGQ-----------RSNRKVKKYRDKFDPRVTAKYDIKALIGRGNFSKVVRVEHRVT 102 Query: 227 REYVAIKVVRSIRKYRDAAMIEIDVLNRLAENERYRSLCVQIQRWFDYRNHICII 391 ++ AIK++ ++ ++ E+ VL R+ S +Q+ F+ ++ + ++ Sbjct: 103 KQPYAIKMIDRVQG-KEVFESEVAVLRRVK-----HSYIIQLIEVFETKDKVYMV 151
>PMK1_CAEEL (Q17446) Mitogen-activated protein kinase pmk-1 (EC 2.7.11.24) (p38| MAP kinase 1) (Stress-activated protein kinase pmk-1) Length = 377 Score = 46.2 bits (108), Expect = 9e-05 Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP NI + + +K++DFG Sbjct: 149 LKYIHSADIIHRDLKPSNI------------------------AVNEDCELKILDFGLAR 184 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V+TR YRAPEI+L + ++ D+WS Sbjct: 185 QTDSEMTGYVATRWYRAPEIMLNWMHYTQTVDVWS 219
>MAPK2_RABIT (P49139) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) (Fragments) Length = 330 Score = 46.2 bits (108), Expect = 9e-05 Identities = 30/97 (30%), Positives = 46/97 (47%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H + + H D+KPEN+L S PK + +KL DFG A Sbjct: 140 IQYLHSINIAHRDVKPENLLYTSKR--------------------PK-AILKLTDFG-FA 177 Query: 562 FDNQEHNSIVS---TRHYRAPEIILGLGWSLPCDIWS 663 + HNS+ + T +Y APE++ + CD+WS Sbjct: 178 KETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWS 214
>KPCD3_MOUSE (Q8K1Y2) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) Length = 889 Score = 46.2 bits (108), Expect = 9e-05 Identities = 28/93 (30%), Positives = 42/93 (45%), Gaps = 2/93 (2%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 +H ++H DLKPEN+LL S+E +KL DFG Sbjct: 689 LHFKNIVHCDLKPENVLLASAE---------------------PFPQVKLCDFGFARIIG 727 Query: 571 QE--HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ S+V T Y APE++ G++ D+WS Sbjct: 728 EKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWS 760
>MCK1_YEAST (P21965) Protein kinase MCK1 (EC 2.7.11.1) (Meiosis and centromere| regulatory kinase) Length = 375 Score = 46.2 bits (108), Expect = 9e-05 Identities = 30/96 (31%), Positives = 45/96 (46%), Gaps = 3/96 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST- 558 M Y+H L + H D+KP N+L+ P++ +K+ DFGS Sbjct: 152 MLYLHGLGVCHRDIKPSNVLVD-----------------------PETGVLKICDFGSAK 188 Query: 559 -AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIW 660 NQ S + +R YRAPE+I+G ++ DIW Sbjct: 189 KLEHNQPSISYICSRFYRAPELIIGCTQYTTQIDIW 224
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 46.2 bits (108), Expect = 9e-05 Identities = 31/95 (32%), Positives = 44/95 (46%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 Y H + H DLKPEN+LL KKN + IK+ DFG A + Sbjct: 229 YCHSFNICHRDLKPENLLL----------DKKNRR-------------IKIADFGMAALE 265 Query: 568 --NQEHNSIVSTRHYRAPEIILGLGW-SLPCDIWS 663 N+ + + HY +PEI++G + P D+WS Sbjct: 266 LPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWS 300
>CDPK3_PLAF7 (Q9NJU9) Calcium-dependent protein kinase 3 (EC 2.7.11.1) (PfCDPK3)| Length = 562 Score = 46.2 bits (108), Expect = 9e-05 Identities = 27/97 (27%), Positives = 45/97 (46%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 ++Y+H + H D+KPEN L + S IK+IDFG + Sbjct: 226 LNYLHIRNICHRDIKPENFLFYD---------------------MTPESLIKIIDFGLAS 264 Query: 562 F---DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + +N E + T +Y AP+++ G ++ CD+WS Sbjct: 265 YFTHNNYEMKTKAGTPYYVAPQVLTG-SYNYKCDMWS 300
>ST17A_HUMAN (Q9UEE5) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) Length = 414 Score = 46.2 bits (108), Expect = 9e-05 Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 +H++H ++H DLKP+NILL S + IK++DFG + Sbjct: 174 VHFLHTRDVVHLDLKPQNILLTSESPL---------------------GDIKIVDFGLSR 212 Query: 562 F--DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +++E I+ T Y APEI+ S+ D+WS Sbjct: 213 ILKNSEELREIMGTPEYVAPEILSYDPISMATDMWS 248
>KPCD3_HUMAN (O94806) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) (Protein kinase EPK2) Length = 890 Score = 46.2 bits (108), Expect = 9e-05 Identities = 28/93 (30%), Positives = 42/93 (45%), Gaps = 2/93 (2%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFDN 570 +H ++H DLKPEN+LL S+E +KL DFG Sbjct: 690 LHFKNIVHCDLKPENVLLASAE---------------------PFPQVKLCDFGFARIIG 728 Query: 571 QE--HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ S+V T Y APE++ G++ D+WS Sbjct: 729 EKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWS 761
>CDC2_DICDI (P34112) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 296 Score = 46.2 bits (108), Expect = 9e-05 Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 Y H R++H DLKP+N+L + + A+KL DFG + Sbjct: 119 YSHGHRILHRDLKPQNLL------------------------IDRQGALKLADFGLARAV 154 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + + + + T YRAPE++LG +S+P D+WS Sbjct: 155 SIPVRVYTHEIVTLWYRAPEVLLGSKSYSVPVDMWS 190 Score = 35.8 bits (81), Expect = 0.12 Identities = 15/34 (44%), Positives = 24/34 (70%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVR 256 RY+ L K+GEGT+G+V + ++ T VA+K +R Sbjct: 9 RYQKLEKLGEGTYGKVYKAKEKATGRMVALKKIR 42
>CC2H2_TRYBB (P54665) Cell division control protein 2 homolog 2 (EC 2.7.11.22)| Length = 345 Score = 46.2 bits (108), Expect = 9e-05 Identities = 34/98 (34%), Positives = 44/98 (44%), Gaps = 4/98 (4%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-ST 558 +H H R +H D+KP NIL+ K S +KL DFG Sbjct: 156 LHECHSRRFVHRDIKPSNILIDR-----------------------KESVVKLADFGLGR 192 Query: 559 AF--DNQEHNSIVSTRHYRAPEIILGLGWSLPC-DIWS 663 AF Q + + V T YRAPE++LG LP D+WS Sbjct: 193 AFRVPLQTYTTEVMTLWYRAPEVLLGDKQYLPAVDVWS 230 Score = 32.3 bits (72), Expect = 1.3 Identities = 15/37 (40%), Positives = 22/37 (59%) Frame = +2 Query: 137 GENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIK 247 G + RY + K+GEG++G V +C D T VA+K Sbjct: 39 GTSTPDRYSRIEKVGEGSYGIVYKCHDNFTGRTVAMK 75
>PAK7_MOUSE (Q8C015) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5) Length = 719 Score = 42.7 bits (99), Expect(2) = 9e-05 Identities = 30/97 (30%), Positives = 43/97 (44%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH D+K ++ILL S IKL DFG A Sbjct: 556 LSYLHNQGVIHRDIKSDSILLTS------------------------DGRIKLSDFGFCA 591 Query: 562 FDNQE---HNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++E S+V T ++ APE+I L + DIWS Sbjct: 592 QVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWS 628 Score = 22.7 bits (47), Expect(2) = 9e-05 Identities = 17/67 (25%), Positives = 31/67 (46%), Gaps = 4/67 (5%) Frame = +2 Query: 173 KMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAENER----YRSL 340 K+GEG+ G V ++ T + VA+K + ++ R + V+ R ++ Y S Sbjct: 454 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNSY 513 Query: 341 CVQIQRW 361 V + W Sbjct: 514 LVGDELW 520
>AKT1_CAEEL (Q17941) Serine/threonine-protein kinase akt-1 (EC 2.7.11.1)| (Protein kinase B akt-1) (PKB akt-1) Length = 541 Score = 37.7 bits (86), Expect(2) = 9e-05 Identities = 21/83 (25%), Positives = 45/83 (54%), Gaps = 5/83 (6%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAENERYRS 337 + L +G+GTFG+V+ C ++ T++ AIK+++ +D + +V + L EN R Sbjct: 193 FDFLKVLGKGTFGKVILCKEKRTQKLYAIKILK-----KDVIIAREEVAHTLTEN-RVLQ 246 Query: 338 LC-----VQIQRWFDYRNHICII 391 C +++ F ++++C + Sbjct: 247 RCKHPFLTELKYSFQEQHYLCFV 269 Score = 27.7 bits (60), Expect(2) = 9e-05 Identities = 10/27 (37%), Positives = 18/27 (66%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKV 468 Y+H +++ D+K EN+LL +IK+ Sbjct: 306 YLHRCDIVYRDMKLENLLLDKDGHIKI 332
>MAPK2_HUMAN (P49137) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) Length = 400 Score = 45.8 bits (107), Expect = 1e-04 Identities = 28/97 (28%), Positives = 45/97 (46%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H + + H D+KPEN+L S ++ +KL DFG A Sbjct: 174 IQYLHSINIAHRDVKPENLLYTSKR---------------------PNAILKLTDFG-FA 211 Query: 562 FDNQEHNSIVS---TRHYRAPEIILGLGWSLPCDIWS 663 + HNS+ + T +Y APE++ + CD+WS Sbjct: 212 KETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWS 248
>ST17A_RABIT (Q9GM70) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) (rDRAK1) Length = 397 Score = 45.8 bits (107), Expect = 1e-04 Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 +H++H ++H DLKP+NILL S + IK++DFG + Sbjct: 157 VHFLHTHDVVHLDLKPQNILLTSESPL---------------------GDIKIVDFGLSR 195 Query: 562 F--DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +++E I+ T Y APEI+ S+ D+WS Sbjct: 196 IVKNSEELREIMGTPEYVAPEILSYDPISMATDMWS 231
>GSK3B_MOUSE (Q9WV60) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 45.8 bits (107), Expect = 1e-04 Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST--A 561 Y+H + H D+KP+N+LL P ++ +KL DFGS Sbjct: 171 YIHSFGICHRDIKPQNLLLD-----------------------PDTAVLKLCDFGSAKQL 207 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + + S + +R+YRAPE+I G ++ D+WS Sbjct: 208 VRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWS 242
>GSK3B_HUMAN (P49841) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 45.8 bits (107), Expect = 1e-04 Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST--A 561 Y+H + H D+KP+N+LL P ++ +KL DFGS Sbjct: 171 YIHSFGICHRDIKPQNLLLD-----------------------PDTAVLKLCDFGSAKQL 207 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + + S + +R+YRAPE+I G ++ D+WS Sbjct: 208 VRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWS 242
>KAPC_CAEEL (P21137) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 404 Score = 45.8 bits (107), Expect = 1e-04 Identities = 29/92 (31%), Positives = 41/92 (44%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 Y+H L LI+ DLKPEN+L+ S+ Y+K+ DFG Sbjct: 194 YLHSLDLIYRDLKPENLLIDSTGYLKI------------------------TDFGFAKRV 229 Query: 568 NQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ T Y APEIIL G++ D W+ Sbjct: 230 KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWA 261
>MAPK2_MOUSE (P49138) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2) Length = 386 Score = 45.8 bits (107), Expect = 1e-04 Identities = 28/97 (28%), Positives = 45/97 (46%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H + + H D+KPEN+L S ++ +KL DFG A Sbjct: 160 IQYLHSINIAHRDVKPENLLYTSKR---------------------PNAILKLTDFG-FA 197 Query: 562 FDNQEHNSIVS---TRHYRAPEIILGLGWSLPCDIWS 663 + HNS+ + T +Y APE++ + CD+WS Sbjct: 198 KETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWS 234
>CDK4_RAT (P35426) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) Length = 303 Score = 45.8 bits (107), Expect = 1e-04 Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++H ++H DLKPENIL+ S + +KL DFG Sbjct: 128 LDFLHANCIVHRDLKPENILVTS------------------------NGTVKLADFGLAR 163 Query: 562 FDNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + +V T YRAPE++L ++ P D+WS Sbjct: 164 IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWS 199
>CDK4_MOUSE (P30285) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) (CRK3) Length = 303 Score = 45.8 bits (107), Expect = 1e-04 Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++H ++H DLKPENIL+ S + +KL DFG Sbjct: 128 LDFLHANCIVHRDLKPENILVTS------------------------NGTVKLADFGLAR 163 Query: 562 FDNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + +V T YRAPE++L ++ P D+WS Sbjct: 164 IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWS 199
>MAPK2_CRILO (P49136) MAP kinase-activated protein kinase 2 (EC 2.7.11.1)| (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (P45-54 HSP27 kinase) (Fragment) Length = 329 Score = 45.8 bits (107), Expect = 1e-04 Identities = 28/97 (28%), Positives = 45/97 (46%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H + + H D+KPEN+L S ++ +KL DFG A Sbjct: 103 IQYLHSINIAHRDVKPENLLYTSKR---------------------PNAILKLTDFG-FA 140 Query: 562 FDNQEHNSIVS---TRHYRAPEIILGLGWSLPCDIWS 663 + HNS+ + T +Y APE++ + CD+WS Sbjct: 141 KETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWS 177
>MK03_HUMAN (P27361) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) Length = 379 Score = 45.8 bits (107), Expect = 1e-04 Identities = 32/101 (31%), Positives = 46/101 (45%), Gaps = 7/101 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP N+L I+ C +K+ DFG Sbjct: 154 LKYIHSANVLHRDLKPSNLL-------------------INTTC-----DLKICDFGLAR 189 Query: 562 FDNQEHN------SIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + EH+ V+TR YRAPEI+L G++ DIWS Sbjct: 190 IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS 230 Score = 30.8 bits (68), Expect = 3.8 Identities = 21/63 (33%), Positives = 30/63 (47%), Gaps = 2/63 (3%) Frame = +2 Query: 128 FDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI--RKYRDAAMIEIDV 301 FD+G RY L +GEG +G V +D + VAIK + + Y + EI + Sbjct: 36 FDVGP----RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI 91 Query: 302 LNR 310 L R Sbjct: 92 LLR 94
>MK03_RAT (P21708) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) (MNK1) Length = 380 Score = 45.8 bits (107), Expect = 1e-04 Identities = 32/101 (31%), Positives = 46/101 (45%), Gaps = 7/101 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP N+L I+ C +K+ DFG Sbjct: 155 LKYIHSANVLHRDLKPSNLL-------------------INTTC-----DLKICDFGLAR 190 Query: 562 FDNQEHN------SIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + EH+ V+TR YRAPEI+L G++ DIWS Sbjct: 191 IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS 231 Score = 30.0 bits (66), Expect = 6.5 Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 2/61 (3%) Frame = +2 Query: 128 FDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI--RKYRDAAMIEIDV 301 FD+G RY L +GEG +G V +D + VAIK + + Y + EI + Sbjct: 37 FDVGP----RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI 92 Query: 302 L 304 L Sbjct: 93 L 93
>MK03_MOUSE (Q63844) Mitogen-activated protein kinase 3 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein 2 kinase) (MNK1) Length = 380 Score = 45.8 bits (107), Expect = 1e-04 Identities = 32/101 (31%), Positives = 46/101 (45%), Gaps = 7/101 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP N+L I+ C +K+ DFG Sbjct: 155 LKYIHSANVLHRDLKPSNLL-------------------INTTC-----DLKICDFGLAR 190 Query: 562 FDNQEHN------SIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + EH+ V+TR YRAPEI+L G++ DIWS Sbjct: 191 IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS 231 Score = 30.8 bits (68), Expect = 3.8 Identities = 21/63 (33%), Positives = 30/63 (47%), Gaps = 2/63 (3%) Frame = +2 Query: 128 FDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI--RKYRDAAMIEIDV 301 FD+G RY L +GEG +G V +D + VAIK + + Y + EI + Sbjct: 37 FDVGP----RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI 92 Query: 302 LNR 310 L R Sbjct: 93 LLR 95
>MK11_MOUSE (Q9WUI1) Mitogen-activated protein kinase 11 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B) Length = 364 Score = 45.4 bits (106), Expect = 1e-04 Identities = 27/95 (28%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + + ++++DFG Sbjct: 138 LKYIHSAGIIHRDLKPSNV------------------------AVNEDCELRILDFGLAP 173 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 ++E V+TR YRAPEI+L + ++ DIWS Sbjct: 174 QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWS 208
>SPEG_BRARE (Q696W0) Striated muscle preferentially expressed protein kinase (EC| 2.7.11.1) Length = 2995 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/98 (28%), Positives = 45/98 (45%), Gaps = 4/98 (4%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +++H D+KP+NI++ + + IK+IDFGS Sbjct: 2789 LEYLHNCKILHLDIKPDNIMVTN------------------------LNVIKIIDFGSAQ 2824 Query: 562 FDN----QEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 N Q+ + + T Y APE++ G P DIWS Sbjct: 2825 RFNPLSLQQCSRYLGTLEYMAPEMLKGDLVGPPADIWS 2862 Score = 37.0 bits (84), Expect = 0.053 Identities = 27/95 (28%), Positives = 39/95 (41%), Gaps = 2/95 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST- 558 + Y+H+ +IH DLKPENIL+ K+ I++ DFG+ Sbjct: 1360 IEYLHQNDIIHLDLKPENILMADQ----------------------KTDQIRICDFGNAL 1397 Query: 559 -AFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIW 660 N+E + APEI+ S DIW Sbjct: 1398 KVKPNEELYCKYGIPEFIAPEIVNQSPISKSTDIW 1432
>DAPK1_MOUSE (Q80YE7) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1442 Score = 45.4 bits (106), Expect = 1e-04 Identities = 33/97 (34%), Positives = 46/97 (47%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--- 552 ++Y+H L++ H DLKPENI+L+ VP + IK+IDFG Sbjct: 127 VYYLHSLQIAHFDLKPENIMLLDR---NVPKPR-----------------IKIIDFGLAH 166 Query: 553 STAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 F N E +I T + APEI+ L D+WS Sbjct: 167 KIDFGN-EFKNIFGTPEFVAPEIVNYEPLGLEADMWS 202
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 M +H +IH DLKP+NILL + P+ ++ + P S +K+ DFG Sbjct: 126 MRLLHSKGIIHRDLKPQNILLSN------PAGRRAN---------PNSIRVKIADFGFAR 170 Query: 562 F--DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + N ++ + Y APE+I+ + D+WS Sbjct: 171 YLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWS 206
>KOM8_YEAST (Q12222) Probable serine/threonine-protein kinase YOL128C (EC| 2.7.11.1) Length = 375 Score = 45.4 bits (106), Expect = 1e-04 Identities = 30/94 (31%), Positives = 42/94 (44%), Gaps = 3/94 (3%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST--AF 564 +H + + H DLKP NIL++ P S K+ DFGS Sbjct: 164 LHSMSICHGDLKPSNILII-----------------------PSSGIAKVCDFGSAQRLD 200 Query: 565 DNQEHNSIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 DN E + +R YRAPE++L ++ DIWS Sbjct: 201 DNTELKTYFCSRFYRAPELLLNSKDYTTQIDIWS 234
>CDK4_PIG (P79432) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 303 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++H ++H DLKPENIL+ S +KL DFG Sbjct: 128 LDFLHANCIVHRDLKPENILVTS------------------------GGTVKLADFGLAR 163 Query: 562 FDNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + +V T YRAPE++L ++ P D+WS Sbjct: 164 IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWS 199
>CDK4_HUMAN (P11802) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) (PSK-J3) Length = 303 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++H ++H DLKPENIL+ S +KL DFG Sbjct: 128 LDFLHANCIVHRDLKPENILVTS------------------------GGTVKLADFGLAR 163 Query: 562 FDNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + +V T YRAPE++L ++ P D+WS Sbjct: 164 IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWS 199
>DAPK1_HUMAN (P53355) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1432 Score = 45.4 bits (106), Expect = 1e-04 Identities = 33/97 (34%), Positives = 46/97 (47%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--- 552 ++Y+H L++ H DLKPENI+L+ VP + IK+IDFG Sbjct: 127 VYYLHSLQIAHFDLKPENIMLLDR---NVPKPR-----------------IKIIDFGLAH 166 Query: 553 STAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 F N E +I T + APEI+ L D+WS Sbjct: 167 KIDFGN-EFKNIFGTPEFVAPEIVNYEPLGLEADMWS 202
>CDPK3_PLAYO (Q7RAV5) Calcium-dependent protein kinase 3 (EC 2.7.11.1)| Length = 538 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/97 (28%), Positives = 42/97 (43%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 ++Y+H + H D+KPEN L S IK+IDFG A Sbjct: 220 LNYLHIRNICHRDIKPENFLFYDKS---------------------TESLIKIIDFGLAA 258 Query: 562 FDNQ---EHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + N E + T +Y AP+++ G + CD+WS Sbjct: 259 YFNDIDYEMKTKAGTPYYVAPQVLTGC-YDYKCDLWS 294
>MK11_HUMAN (Q15759) Mitogen-activated protein kinase 11 (EC 2.7.11.24)| (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress-activated protein kinase 2) Length = 372 Score = 45.4 bits (106), Expect = 1e-04 Identities = 27/95 (28%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + + ++++DFG Sbjct: 146 LKYIHSAGIIHRDLKPSNV------------------------AVNEDCELRILDFGLAR 181 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 ++E V+TR YRAPEI+L + ++ DIWS Sbjct: 182 QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWS 216
>KAPCG_HUMAN (P22612) cAMP-dependent protein kinase, gamma-catalytic subunit (EC| 2.7.11.11) (PKA C-gamma) Length = 350 Score = 45.4 bits (106), Expect = 1e-04 Identities = 29/94 (30%), Positives = 40/94 (42%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H L LIH DLKPEN+L+ Y++V DFG Sbjct: 154 VQYLHSLDLIHRDLKPENLLIDQQGYLQV------------------------TDFGFAK 189 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ T Y APEIIL G++ D W+ Sbjct: 190 RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWA 223
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/94 (29%), Positives = 50/94 (53%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 Y+H+ ++H D+KPENILL +N ++ IK++DFG ++F Sbjct: 180 YLHKHNIVHRDIKPENILL------------ENKHSLLN---------IKIVDFGLSSFF 218 Query: 568 NQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++++ + T +Y APE +L ++ CD+WS Sbjct: 219 SKDNKLRDRLGTAYYIAPE-VLRKKYNEKCDVWS 251 Score = 29.6 bits (65), Expect = 8.5 Identities = 20/65 (30%), Positives = 29/65 (44%), Gaps = 4/65 (6%) Frame = +2 Query: 116 GHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIR----KYRDAA 283 G YV + Y + K+G G +G VL C ++ AIKV++ + KY Sbjct: 41 GMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITN 100 Query: 284 MIEID 298 IE D Sbjct: 101 KIECD 105
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 45.4 bits (106), Expect = 1e-04 Identities = 28/94 (29%), Positives = 50/94 (53%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 Y+H+ ++H D+KPENILL +N ++ IK++DFG ++F Sbjct: 180 YLHKHNIVHRDIKPENILL------------ENKHSLLN---------IKIVDFGLSSFF 218 Query: 568 NQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++++ + T +Y APE +L ++ CD+WS Sbjct: 219 SKDNKLRDRLGTAYYIAPE-VLRKKYNEKCDVWS 251 Score = 29.6 bits (65), Expect = 8.5 Identities = 20/65 (30%), Positives = 29/65 (44%), Gaps = 4/65 (6%) Frame = +2 Query: 116 GHYVFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIR----KYRDAA 283 G YV + Y + K+G G +G VL C ++ AIKV++ + KY Sbjct: 41 GMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITN 100 Query: 284 MIEID 298 IE D Sbjct: 101 KIECD 105
>AKT1_DROME (Q8INB9) RAC serine/threonine-protein kinase (EC 2.7.11.1)| (DRAC-PK) (Akt) (Dakt1) (Protein kinase B) (PKB) Length = 611 Score = 34.7 bits (78), Expect(2) = 2e-04 Identities = 18/82 (21%), Positives = 44/82 (53%), Gaps = 4/82 (4%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAENERYRS 337 ++ L +G+GTFG+V+ C ++ T + AIK+++ ++ + + +V + L E+ +S Sbjct: 266 FEFLKVLGKGTFGKVILCREKATAKLYAIKILK-----KEVIIQKDEVAHTLTESRVLKS 320 Query: 338 ----LCVQIQRWFDYRNHICII 391 + ++ F + +C + Sbjct: 321 TNHPFLISLKYSFQTNDRLCFV 342 Score = 30.0 bits (66), Expect(2) = 2e-04 Identities = 24/91 (26%), Positives = 35/91 (38%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 Y+H +I+ DLK EN+LL +IKV +D I +G T Sbjct: 379 YLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKED---------------ITYGRTT-- 421 Query: 568 NQEHNSIVSTRHYRAPEIILGLGWSLPCDIW 660 + T Y APE++ + D W Sbjct: 422 ----KTFCGTPEYLAPEVLDDNDYGQAVDWW 448
>TTBK1_HUMAN (Q5TCY1) Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau| kinase) Length = 1321 Score = 42.7 bits (99), Expect(2) = 2e-04 Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 12/79 (15%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRL------- 313 R+K+L K+G G FG + E D TRE VA+K V S ++ + +E+ VL +L Sbjct: 33 RWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKMEVAVLKKLQGKDHVC 91 Query: 314 -----AENERYRSLCVQIQ 355 NE++ + +Q+Q Sbjct: 92 RFIGCGRNEKFNYVVMQLQ 110 Score = 21.6 bits (44), Expect(2) = 2e-04 Identities = 6/18 (33%), Positives = 11/18 (61%) Frame = +1 Query: 391 MHELRLIHTDLKPENILL 444 +H + +H D+KP N + Sbjct: 145 IHSVGFLHRDIKPSNFAM 162
>TTBK2_HUMAN (Q6IQ55) Tau-tubulin kinase 2 (EC 2.7.11.1)| Length = 1244 Score = 42.7 bits (99), Expect(2) = 2e-04 Identities = 26/89 (29%), Positives = 46/89 (51%), Gaps = 12/89 (13%) Frame = +2 Query: 125 VFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVL 304 + +G + R+K+L K+G G FG + + D TRE VA+K V S ++ + +E+ VL Sbjct: 10 ILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALK-VESAQQPKQVLKMEVAVL 68 Query: 305 NRL------------AENERYRSLCVQIQ 355 +L N+R+ + +Q+Q Sbjct: 69 KKLQGKDHVCRFIGCGRNDRFNYVVMQLQ 97 Score = 21.6 bits (44), Expect(2) = 2e-04 Identities = 6/18 (33%), Positives = 11/18 (61%) Frame = +1 Query: 391 MHELRLIHTDLKPENILL 444 +H + +H D+KP N + Sbjct: 132 IHSVGFLHRDIKPSNFAM 149
>TTBK2_MOUSE (Q3UVR3) Tau-tubulin kinase 2| Length = 1243 Score = 42.7 bits (99), Expect(2) = 2e-04 Identities = 26/89 (29%), Positives = 46/89 (51%), Gaps = 12/89 (13%) Frame = +2 Query: 125 VFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVL 304 + +G + R+K+L K+G G FG + + D TRE VA+K V S ++ + +E+ VL Sbjct: 10 ILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALK-VESAQQPKQVLKMEVAVL 68 Query: 305 NRL------------AENERYRSLCVQIQ 355 +L N+R+ + +Q+Q Sbjct: 69 KKLQGKDHVCRFIGCGRNDRFNYVVMQLQ 97 Score = 21.6 bits (44), Expect(2) = 2e-04 Identities = 6/18 (33%), Positives = 11/18 (61%) Frame = +1 Query: 391 MHELRLIHTDLKPENILL 444 +H + +H D+KP N + Sbjct: 132 IHSVGFLHRDIKPSNFAM 149
>KPC1_CANAL (P43057) Protein kinase C-like 1 (EC 2.7.11.13) (PKC 1)| Length = 1097 Score = 33.9 bits (76), Expect(2) = 2e-04 Identities = 23/94 (24%), Positives = 40/94 (42%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y H+ +++ DLK +NILL + +IK+ +D H KS+ Sbjct: 883 LKYFHDNGIVYRDLKLDNILLTTKGHIKIGDYGLCKEDMWH-----KSTT---------- 927 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ T + APEI+ G + D W+ Sbjct: 928 ------STFCGTPEFMAPEIVAGKAYDRSVDWWA 955 Score = 30.4 bits (67), Expect(2) = 2e-04 Identities = 19/80 (23%), Positives = 38/80 (47%), Gaps = 2/80 (2%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVVRS--IRKYRDAAMIEIDVLNRLAENERY 331 ++ L+ +G+G FG+V+ R T + AIKV++ I + +A ++ + L N+ Sbjct: 770 FQFLAVLGKGNFGKVMLAESRHTSKLCAIKVLKKDFIVENDEAESVKSEKRVFLTANKEM 829 Query: 332 RSLCVQIQRWFDYRNHICII 391 + + F N I + Sbjct: 830 HPFLLNLHCCFQTENRIYFV 849
>CHK2_MOUSE (Q9Z265) Serine/threonine-protein kinase Chk2 (EC 2.7.11.1)| Length = 546 Score = 45.1 bits (105), Expect = 2e-04 Identities = 33/99 (33%), Positives = 48/99 (48%), Gaps = 5/99 (5%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+HE +IH DLKPEN+LL +SQ+E CL IK+ DFG + Sbjct: 339 VQYLHENGIIHRDLKPENVLL-------------SSQEE---DCL-----IKITDFGQSK 377 Query: 562 F--DNQEHNSIVSTRHYRAPEIILG---LGWSLPCDIWS 663 + ++ T Y APE+++ G+S D WS Sbjct: 378 ILGETSLMRTLCGTPTYLAPEVLVSNGTAGYSRAVDCWS 416
>CDC2_DROME (P23572) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 297 Score = 45.1 bits (105), Expect = 2e-04 Identities = 31/96 (32%), Positives = 44/96 (45%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 + H R++H DLKP+N+L + KS IK+ DFG S Sbjct: 118 FCHRRRVLHRDLKPQNLL------------------------IDKSGLIKVADFGLGRSF 153 Query: 559 AFDNQEHNSIVSTRHYRAPEIILGL-GWSLPCDIWS 663 + + + T YRAPE++LG +S P DIWS Sbjct: 154 GIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWS 189
>YL205_MIMIV (Q5UQ24) Putative serine/threonine-protein kinase L205 (EC| 2.7.11.1) Length = 542 Score = 45.1 bits (105), Expect = 2e-04 Identities = 19/42 (45%), Positives = 28/42 (66%) Frame = +1 Query: 538 LIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 L DFG++ F ++ + + R YRAPE+IL L ++ CDIWS Sbjct: 378 LTDFGNSYFFDKRTRNEIQDRRYRAPEVILDLNYTFCCDIWS 419
>GSK3B_RAT (P18266) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) (Factor A) (FA) Length = 420 Score = 45.1 bits (105), Expect = 2e-04 Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST--A 561 Y+H + H D+KP+N+LL P ++ +KL DFGS Sbjct: 171 YIHSFGICHRDIKPQNLLLD-----------------------PDTAVLKLCDFGSAKQL 207 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + + S + +R+YRAPE+I G ++ D+WS Sbjct: 208 VRGEPNVSYICSRYYRAPELIFGATDYTSSIDMWS 242
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 45.1 bits (105), Expect = 2e-04 Identities = 31/94 (32%), Positives = 42/94 (44%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-STAF 564 Y+H L ++H DLKPEN L S K S +K+IDFG S Sbjct: 181 YLHSLNIVHRDLKPENFLFQSEN---------------------KDSLLKIIDFGLSKNL 219 Query: 565 DNQEHNSI-VSTRHYRAPEIILGLGWSLPCDIWS 663 E + T +Y AP+++ G + CDIWS Sbjct: 220 GTGEFTTTKAGTPYYVAPQVLDG-KYDKKCDIWS 252 Score = 31.6 bits (70), Expect = 2.2 Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 4/96 (4%) Frame = +2 Query: 146 LTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIR-KYRDAAMIEIDVLNRLAEN 322 L +Y I K+G+GT+G V + D+ T + AIK + R K + EI+++ +L Sbjct: 67 LEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHP 126 Query: 323 ERYRSLCVQIQRWFDYRNHICII---CTNYALFTLI 421 V++ ++ N+I +I C+ LF I Sbjct: 127 N-----IVKLYETYENDNYIYLIMELCSGRELFDSI 157
>KAPC_DROME (P12370) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 352 Score = 45.1 bits (105), Expect = 2e-04 Identities = 30/92 (32%), Positives = 40/92 (43%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAFD 567 Y+H L LI+ DLKPEN+L+ S Y+KV DFG Sbjct: 158 YLHYLDLIYRDLKPENLLIDSQGYLKV------------------------TDFGFAKRV 193 Query: 568 NQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ T Y APEIIL G++ D W+ Sbjct: 194 KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWA 225
>DAPK2_MOUSE (Q8VDF3) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 45.1 bits (105), Expect = 2e-04 Identities = 32/96 (33%), Positives = 44/96 (45%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--S 555 ++Y+H ++ H DLKPENI+L+ I +P IKLIDFG Sbjct: 137 VNYLHTKKIAHFDLKPENIMLLDKN-IPIPH-------------------IKLIDFGLAH 176 Query: 556 TAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 D E +I T + APEI+ L D+WS Sbjct: 177 EIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWS 212
>DAPK2_HUMAN (Q9UIK4) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 45.1 bits (105), Expect = 2e-04 Identities = 32/96 (33%), Positives = 44/96 (45%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--S 555 ++Y+H ++ H DLKPENI+L+ I +P IKLIDFG Sbjct: 137 VNYLHTKKIAHFDLKPENIMLLDKN-IPIPH-------------------IKLIDFGLAH 176 Query: 556 TAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 D E +I T + APEI+ L D+WS Sbjct: 177 EIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWS 212
>MEK2_CAEEL (Q10664) Dual specificity mitogen-activated protein kinase kinase| mek-2 (EC 2.7.12.2) (MAP kinase kinase mek-2) Length = 387 Score = 45.1 bits (105), Expect = 2e-04 Identities = 31/90 (34%), Positives = 43/90 (47%), Gaps = 1/90 (1%) Frame = +1 Query: 397 ELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-STAFDNQ 573 E++++H D+KP N+L+ NS EI KL DFG S + Sbjct: 188 EIKILHRDVKPSNMLV-------------NSNGEI-----------KLCDFGVSGMLIDS 223 Query: 574 EHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 NS V TR Y APE + G +++ DIWS Sbjct: 224 MANSFVGTRSYMAPERLTGSHYTISSDIWS 253
>GSK3_SCHPO (Q10452) Protein kinase gsk3 (EC 2.7.11.1) (Protein kinaae skp1)| Length = 387 Score = 45.1 bits (105), Expect = 2e-04 Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 3/95 (3%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAF- 564 Y+H + H D+KP+N+LL P++ +KL DFGS Sbjct: 147 YIHASGICHRDIKPQNLLLD-----------------------PENGILKLCDFGSAKIL 183 Query: 565 -DNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + + S + +R+YRAPE+I G ++ DIWS Sbjct: 184 VAGEPNVSYICSRYYRAPELIFGATDYTHAIDIWS 218
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 45.1 bits (105), Expect = 2e-04 Identities = 31/94 (32%), Positives = 42/94 (44%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-STAF 564 Y+H L ++H DLKPEN L S K S +K+IDFG S Sbjct: 181 YLHSLNIVHRDLKPENFLFQSEN---------------------KDSLLKIIDFGLSKNL 219 Query: 565 DNQEHNSI-VSTRHYRAPEIILGLGWSLPCDIWS 663 E + T +Y AP+++ G + CDIWS Sbjct: 220 GTGEFTTTKAGTPYYVAPQVLDG-KYDKKCDIWS 252 Score = 31.6 bits (70), Expect = 2.2 Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 4/96 (4%) Frame = +2 Query: 146 LTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIR-KYRDAAMIEIDVLNRLAEN 322 L +Y I K+G+GT+G V + D+ T + AIK + R K + EI+++ +L Sbjct: 67 LEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHP 126 Query: 323 ERYRSLCVQIQRWFDYRNHICII---CTNYALFTLI 421 V++ ++ N+I +I C+ LF I Sbjct: 127 N-----IVKLYETYENDNYIYLIMELCSGRELFDSI 157
>MK12_BRARE (O42376) Mitogen-activated protein kinase 12 (EC 2.7.11.24)| (Stress-activated protein kinase 3) Length = 363 Score = 45.1 bits (105), Expect = 2e-04 Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H +IH DLKP N+ + N + E+ K++DFG Sbjct: 139 LKYIHAAGIIHRDLKPGNLAI-------------NEECEL-----------KILDFGLAR 174 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V TR YRAPE+IL + ++ DIWS Sbjct: 175 QTDSEMTGYVVTRWYRAPEVILSWMHYTQTVDIWS 209 Score = 30.0 bits (66), Expect = 6.5 Identities = 15/31 (48%), Positives = 18/31 (58%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIK 247 RYK L ++G G +G V DR T VAIK Sbjct: 24 RYKDLKQVGTGAYGTVCYALDRRTGAKVAIK 54
>IKKB_HUMAN (O14920) Inhibitor of nuclear factor kappa B kinase beta subunit| (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) Length = 756 Score = 45.1 bits (105), Expect = 2e-04 Identities = 33/96 (34%), Positives = 44/96 (45%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+HE R+IH DLKPENI+L E Q IH K+ID G Sbjct: 133 LRYLHENRIIHRDLKPENIVLQQGE-----------QRLIH----------KIIDLGYAK 171 Query: 562 FDNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 +Q S V T Y APE++ +++ D WS Sbjct: 172 ELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWS 207 Score = 32.0 bits (71), Expect = 1.7 Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 2/54 (3%) Frame = +2 Query: 158 YKILSKMGEGTFGRVLECWDRETREYVAIKVVRS--IRKYRDAAMIEIDVLNRL 313 +++ ++G G FG V+ ++ET E +AIK R + R+ +EI ++ RL Sbjct: 15 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRL 68
>CDKL1_HUMAN (Q00532) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIALRE) (Protein kinase p42 KKIALRE) Length = 357 Score = 45.1 bits (105), Expect = 2e-04 Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 4/98 (4%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 +++ H+ IH D+KPENIL+ K S IKL DFG Sbjct: 114 VNFCHKHNCIHRDVKPENILIT------------------------KHSVIKLCDFGFAR 149 Query: 562 F---DNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + + V+TR YR+PE+++G + P D+W+ Sbjct: 150 LLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWA 187 Score = 35.0 bits (79), Expect = 0.20 Identities = 14/31 (45%), Positives = 24/31 (77%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIK 247 +Y+ + K+GEG++G V +C +R+T + VAIK Sbjct: 3 KYEKIGKIGEGSYGVVFKCRNRDTGQIVAIK 33
>CDC2_MAIZE (P23111) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34cdc2) Length = 294 Score = 45.1 bits (105), Expect = 2e-04 Identities = 31/96 (32%), Positives = 45/96 (46%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 Y H R++H DLKP+N+L+ +++A+KL DFG + Sbjct: 117 YCHSHRVLHRDLKPQNLLIDR-----------------------RTNALKLADFGLARAF 153 Query: 559 AFDNQEHNSIVSTRHYRAPEIILGL-GWSLPCDIWS 663 + V T YRAPEI+LG +S P D+WS Sbjct: 154 GIPVRTFTHEVVTLWYRAPEILLGARQYSTPVDVWS 189 Score = 34.7 bits (78), Expect = 0.26 Identities = 14/34 (41%), Positives = 24/34 (70%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVR 256 +Y+ + K+GEGT+G V + D+ T E +A+K +R Sbjct: 3 QYEKVEKIGEGTYGVVYKALDKATNETIALKKIR 36
>CDK4_XENLA (Q91727) Cell division protein kinase 4 (EC 2.7.11.22)| (Cyclin-dependent kinase 4) Length = 319 Score = 44.7 bits (104), Expect = 3e-04 Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 2/96 (2%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + ++H ++H DLKPENIL+ S +KL DFG Sbjct: 128 LEFLHLNCIVHRDLKPENILVTS------------------------GGQVKLADFGLAR 163 Query: 562 FDNQEH--NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + + +V T YRAPE++L ++ P D+WS Sbjct: 164 IYSCQMALTPVVVTLWYRAPEVLLQSTYATPVDVWS 199
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 44.7 bits (104), Expect = 3e-04 Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 4/98 (4%) Frame = +1 Query: 382 MHYMH---ELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG 552 MHY+H +++IH DLK N+++ + +K+ DFG Sbjct: 118 MHYLHMEAPVKVIHRDLKSRNVVIAA------------------------DGVLKICDFG 153 Query: 553 STAFDNQ-EHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ F N H S+V T + APE+I L S CD +S Sbjct: 154 ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYS 191
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 44.7 bits (104), Expect = 3e-04 Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 4/98 (4%) Frame = +1 Query: 382 MHYMH---ELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG 552 MHY+H +++IH DLK N+++ + +K+ DFG Sbjct: 118 MHYLHMEAPVKVIHRDLKSRNVVIAA------------------------DGVLKICDFG 153 Query: 553 STAFDNQ-EHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 ++ F N H S+V T + APE+I L S CD +S Sbjct: 154 ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYS 191
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 44.7 bits (104), Expect = 3e-04 Identities = 31/96 (32%), Positives = 44/96 (45%), Gaps = 1/96 (1%) Frame = +1 Query: 379 YMHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST 558 Y+H M LIH DLKP N+LLV+ + +K+ DFG T Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAG-----------------------GTVLKICDFG-T 178 Query: 559 AFDNQEH-NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 A D Q H + + + APE+ G +S CD++S Sbjct: 179 ACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFS 214
>MP2K2_HUMAN (P36507) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 44.7 bits (104), Expect = 3e-04 Identities = 34/96 (35%), Positives = 45/96 (46%), Gaps = 1/96 (1%) Frame = +1 Query: 379 YMHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-S 555 Y+ H++ +H D+KP NIL+ NS+ EI KL DFG S Sbjct: 183 YLREKHQI--MHRDVKPSNILV-------------NSRGEI-----------KLCDFGVS 216 Query: 556 TAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + NS V TR Y APE + G +S+ DIWS Sbjct: 217 GQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWS 252
>PHOT2_ARATH (P93025) Phototropin-2 (EC 2.7.11.1) (Defective in chloroplast| avoidance protein 1) (Non phototropic hypocotyl 1-like protein 1) (NPH1-like 1) (AtKin7) Length = 915 Score = 44.7 bits (104), Expect = 3e-04 Identities = 33/102 (32%), Positives = 48/102 (47%), Gaps = 8/102 (7%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVP----SSKKNSQDEIHCKCLP----KSSAIK 537 + Y+H L +++ DLKPENILL +I + S ++ P +S + Sbjct: 690 LEYLHCLGIVYRDLKPENILLKKDGHIVLADFDLSFMTTCTPQLIIPAAPSKRRRSKSQP 749 Query: 538 LIDFGSTAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 L F A + + NS V T Y APEII G G + D W+ Sbjct: 750 LPTF--VAEPSTQSNSFVGTEEYIAPEIITGAGHTSAIDWWA 789
>MK13_RAT (Q9WTY9) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 366 Score = 44.7 bits (104), Expect = 3e-04 Identities = 27/95 (28%), Positives = 42/95 (44%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP N+ + + +K++DFG Sbjct: 138 LKYIHSAGIVHRDLKPGNL------------------------AVNEDCELKILDFGLAR 173 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V TR YRAPE+IL + ++ DIWS Sbjct: 174 HTDAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWS 208
>MK13_MOUSE (Q9Z1B7) Mitogen-activated protein kinase 13 (EC 2.7.11.24)| (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 366 Score = 44.7 bits (104), Expect = 3e-04 Identities = 27/95 (28%), Positives = 42/95 (44%), Gaps = 1/95 (1%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP N+ + + +K++DFG Sbjct: 138 LKYIHSAGIVHRDLKPGNL------------------------AVNEDCELKILDFGLAR 173 Query: 562 FDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + E V TR YRAPE+IL + ++ DIWS Sbjct: 174 HTDTEMTGYVVTRWYRAPEVILSWMHYNQTVDIWS 208
>KCC2G_HUMAN (Q13555) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 558 Score = 44.7 bits (104), Expect = 3e-04 Identities = 29/97 (29%), Positives = 45/97 (46%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--- 552 ++++H+ ++H DLKPEN+LL S KC K +A+KL DFG Sbjct: 124 VNHIHQHDIVHRDLKPENLLLAS-------------------KC--KGAAVKLADFGLAI 162 Query: 553 STAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + Q T Y +PE++ + P DIW+ Sbjct: 163 EVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWA 199
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 44.7 bits (104), Expect = 3e-04 Identities = 32/98 (32%), Positives = 46/98 (46%), Gaps = 4/98 (4%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG-ST 558 +++ H R++H DLKP+N+L + IKL DFG S Sbjct: 116 IYFCHRRRVLHRDLKPQNLL------------------------IDNKGVIKLADFGLSR 151 Query: 559 AF--DNQEHNSIVSTRHYRAPEIILGL-GWSLPCDIWS 663 AF + + V T YRAPE++LG +S P D+WS Sbjct: 152 AFGVPVRVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWS 189
>KCC2G_RAT (P11730) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 527 Score = 44.7 bits (104), Expect = 3e-04 Identities = 29/97 (29%), Positives = 45/97 (46%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--- 552 ++++H+ ++H DLKPEN+LL S KC K +A+KL DFG Sbjct: 124 VNHIHQHDIVHRDLKPENLLLAS-------------------KC--KGAAVKLADFGLAI 162 Query: 553 STAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + Q T Y +PE++ + P DIW+ Sbjct: 163 EVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWA 199
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 44.7 bits (104), Expect = 3e-04 Identities = 31/96 (32%), Positives = 44/96 (45%), Gaps = 1/96 (1%) Frame = +1 Query: 379 YMHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGST 558 Y+H M LIH DLKP N+LLV+ + +K+ DFG T Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAG-----------------------GTVLKICDFG-T 178 Query: 559 AFDNQEH-NSIVSTRHYRAPEIILGLGWSLPCDIWS 663 A D Q H + + + APE+ G +S CD++S Sbjct: 179 ACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFS 214
>KGP2_RAT (Q64595) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 44.7 bits (104), Expect = 3e-04 Identities = 29/94 (30%), Positives = 40/94 (42%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 Y+H L +I+ DLKPEN++L + Y +KL+DFG Sbjct: 566 YLHRLGIIYRDLKPENLILDADGY------------------------LKLVDFGFAKKI 601 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 Q+ + T Y APE+IL G D WS Sbjct: 602 GSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWS 635
>KGP2_HUMAN (Q13237) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 44.7 bits (104), Expect = 3e-04 Identities = 29/94 (30%), Positives = 40/94 (42%), Gaps = 2/94 (2%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--STA 561 Y+H L +I+ DLKPEN++L + Y +KL+DFG Sbjct: 566 YLHRLGIIYRDLKPENLILDAEGY------------------------LKLVDFGFAKKI 601 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 Q+ + T Y APE+IL G D WS Sbjct: 602 GSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWS 635
>KCC2G_MOUSE (Q923T9) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 529 Score = 44.7 bits (104), Expect = 3e-04 Identities = 29/97 (29%), Positives = 45/97 (46%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--- 552 ++++H+ ++H DLKPEN+LL S KC K +A+KL DFG Sbjct: 124 VNHIHQHDIVHRDLKPENLLLAS-------------------KC--KGAAVKLADFGLAI 162 Query: 553 STAFDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + Q T Y +PE++ + P DIW+ Sbjct: 163 EVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWA 199
>MK01_XENLA (P26696) Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Myelin| xP42 protein kinase) (Myelin basic protein kinase) (MBP kinase) (M phase MAP kinase) Length = 361 Score = 44.7 bits (104), Expect = 3e-04 Identities = 30/101 (29%), Positives = 46/101 (45%), Gaps = 7/101 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP N+LL + + +K+ DFG Sbjct: 140 LKYIHSANVLHRDLKPSNLLLNT------------------------TCDLKICDFGLAR 175 Query: 562 FDNQEHN------SIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + +H+ V+TR YRAPEI+L G++ DIWS Sbjct: 176 VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS 216
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 44.7 bits (104), Expect = 3e-04 Identities = 30/96 (31%), Positives = 43/96 (44%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 + H R++H DLKP+N+L + IKL DFG + Sbjct: 118 FCHSRRVLHRDLKPQNLL------------------------IDDKGTIKLADFGLARAF 153 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + + V T YR+PE++LG G+S P DIWS Sbjct: 154 GIPIRVYTHEVVTLWYRSPEVLLGSAGYSTPVDIWS 189
>CDKL1_RAT (Q66HE7) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 44.7 bits (104), Expect = 3e-04 Identities = 29/98 (29%), Positives = 44/98 (44%), Gaps = 4/98 (4%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 +++ H+ IH D+KPENIL+ K S IKL DFG Sbjct: 114 VNFCHKHNCIHRDVKPENILIT------------------------KHSVIKLCDFGFAR 149 Query: 562 F---DNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + V+TR YR+PE+++G + P D+W+ Sbjct: 150 LLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWA 187 Score = 35.0 bits (79), Expect = 0.20 Identities = 14/31 (45%), Positives = 24/31 (77%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIK 247 +Y+ + K+GEG++G V +C +R+T + VAIK Sbjct: 3 KYEKIGKIGEGSYGVVFKCRNRDTGQIVAIK 33
>MK01_HUMAN (P28482) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 44.7 bits (104), Expect = 3e-04 Identities = 30/101 (29%), Positives = 46/101 (45%), Gaps = 7/101 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP N+LL + + +K+ DFG Sbjct: 136 LKYIHSANVLHRDLKPSNLLLNT------------------------TCDLKICDFGLAR 171 Query: 562 FDNQEHN------SIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + +H+ V+TR YRAPEI+L G++ DIWS Sbjct: 172 VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS 212 Score = 33.9 bits (76), Expect = 0.45 Identities = 23/64 (35%), Positives = 32/64 (50%), Gaps = 2/64 (3%) Frame = +2 Query: 125 VFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI--RKYRDAAMIEID 298 VFD+G RY LS +GEG +G V +D + VAIK + + Y + EI Sbjct: 17 VFDVGP----RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIK 72 Query: 299 VLNR 310 +L R Sbjct: 73 ILLR 76
>MK01_BOVIN (P46196) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 44.7 bits (104), Expect = 3e-04 Identities = 30/101 (29%), Positives = 46/101 (45%), Gaps = 7/101 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP N+LL + + +K+ DFG Sbjct: 136 LKYIHSANVLHRDLKPSNLLLNT------------------------TCDLKICDFGLAR 171 Query: 562 FDNQEHN------SIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + +H+ V+TR YRAPEI+L G++ DIWS Sbjct: 172 VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS 212 Score = 33.9 bits (76), Expect = 0.45 Identities = 23/64 (35%), Positives = 32/64 (50%), Gaps = 2/64 (3%) Frame = +2 Query: 125 VFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI--RKYRDAAMIEID 298 VFD+G RY LS +GEG +G V +D + VAIK + + Y + EI Sbjct: 17 VFDVGP----RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIK 72 Query: 299 VLNR 310 +L R Sbjct: 73 ILLR 76
>CDC2A_ANTMA (Q38772) Cell division control protein 2 homolog A (EC 2.7.11.22)| (EC 2.7.11.23) Length = 294 Score = 44.7 bits (104), Expect = 3e-04 Identities = 31/96 (32%), Positives = 45/96 (46%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 Y H R++H DLKP+N+L+ +++A+KL DFG + Sbjct: 117 YCHSHRVLHRDLKPQNLLIDR-----------------------RTNALKLADFGLARAF 153 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + V T YRAPEI+LG +S P D+WS Sbjct: 154 GIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWS 189 Score = 35.0 bits (79), Expect = 0.20 Identities = 15/34 (44%), Positives = 24/34 (70%) Frame = +2 Query: 155 RYKILSKMGEGTFGRVLECWDRETREYVAIKVVR 256 +Y+ + K+GEGT+G V + DR T E +A+K +R Sbjct: 3 QYEKVEKIGEGTYGVVYKARDRVTNETIALKKIR 36
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 44.7 bits (104), Expect = 3e-04 Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG--S 555 + ++H L +++ DLKPENILL + +IKV DFG Sbjct: 217 LEHLHSLGIVYRDLKPENILLDADGHIKV------------------------TDFGLSK 252 Query: 556 TAFDNQEHN-SIVSTRHYRAPEIILGLGWSLPCDIWS 663 A D+++ S T Y APE+I G S+ D WS Sbjct: 253 EAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWS 289 Score = 38.1 bits (87), Expect = 0.024 Identities = 22/97 (22%), Positives = 41/97 (42%), Gaps = 3/97 (3%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++ H DL NIL + S+++++DFG Sbjct: 560 VQYLHSQQVAHRDLTAANILFALKD--------------------GDPSSLRIVDFGFAK 599 Query: 562 FDNQEHNSIVS---TRHYRAPEIILGLGWSLPCDIWS 663 E+ +++ T + APE++ G+ CD+WS Sbjct: 600 QSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWS 636 Score = 32.0 bits (71), Expect = 1.7 Identities = 20/59 (33%), Positives = 32/59 (54%) Frame = +2 Query: 149 TRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSIRKYRDAAMIEIDVLNRLAENE 325 T Y+IL K+G G V +C + TR A+K+V +K A E+D+L R + ++ Sbjct: 451 TDDYEILEKIGNGAHSVVHKCQMKATRRKYAVKIV---KKAVFDATEEVDILLRHSHHQ 506
>MK01_RAT (P63086) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 44.7 bits (104), Expect = 3e-04 Identities = 30/101 (29%), Positives = 46/101 (45%), Gaps = 7/101 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP N+LL + + +K+ DFG Sbjct: 134 LKYIHSANVLHRDLKPSNLLLNT------------------------TCDLKICDFGLAR 169 Query: 562 FDNQEHN------SIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + +H+ V+TR YRAPEI+L G++ DIWS Sbjct: 170 VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS 210 Score = 33.5 bits (75), Expect = 0.59 Identities = 23/64 (35%), Positives = 32/64 (50%), Gaps = 2/64 (3%) Frame = +2 Query: 125 VFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI--RKYRDAAMIEID 298 VFD+G RY LS +GEG +G V +D + VAIK + + Y + EI Sbjct: 15 VFDVGP----RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIK 70 Query: 299 VLNR 310 +L R Sbjct: 71 ILLR 74
>MK01_MOUSE (P63085) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 44.7 bits (104), Expect = 3e-04 Identities = 30/101 (29%), Positives = 46/101 (45%), Gaps = 7/101 (6%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP N+LL + + +K+ DFG Sbjct: 134 LKYIHSANVLHRDLKPSNLLLNT------------------------TCDLKICDFGLAR 169 Query: 562 FDNQEHN------SIVSTRHYRAPEIIL-GLGWSLPCDIWS 663 + +H+ V+TR YRAPEI+L G++ DIWS Sbjct: 170 VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS 210 Score = 33.5 bits (75), Expect = 0.59 Identities = 23/64 (35%), Positives = 32/64 (50%), Gaps = 2/64 (3%) Frame = +2 Query: 125 VFDLGENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVVRSI--RKYRDAAMIEID 298 VFD+G RY LS +GEG +G V +D + VAIK + + Y + EI Sbjct: 15 VFDVGP----RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIK 70 Query: 299 VLNR 310 +L R Sbjct: 71 ILLR 74
>GRK6_RAT (P97711) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK6) Length = 576 Score = 32.7 bits (73), Expect(2) = 3e-04 Identities = 26/93 (27%), Positives = 38/93 (40%), Gaps = 2/93 (2%) Frame = +1 Query: 391 MHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTAF-- 564 +H R+++ DLKPENILL D H I++ D G T Sbjct: 302 LHRERIVYRDLKPENILL---------------DDHGH---------IRISDLGLTVHVP 337 Query: 565 DNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 + Q V T Y APE++ ++ D W+ Sbjct: 338 EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWA 370 Score = 30.8 bits (68), Expect(2) = 3e-04 Identities = 25/90 (27%), Positives = 47/90 (52%), Gaps = 4/90 (4%) Frame = +2 Query: 140 ENLTRRYKILSKMGEGTFGRVLECWDRETREYVAIKVV--RSIRKYRDAAMI--EIDVLN 307 +N R+Y++L G+G FG V C R T + A K + + I+K + AM E +L Sbjct: 183 KNTFRQYRVL---GKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 Query: 308 RLAENERYRSLCVQIQRWFDYRNHICIICT 397 ++ N R+ V + ++ ++ +C++ T Sbjct: 240 KV--NSRF---VVSLAYAYETKDALCLVLT 264
>MAST2_MOUSE (Q60592) Microtubule-associated serine/threonine-protein kinase 2| (EC 2.7.11.1) Length = 1734 Score = 44.3 bits (103), Expect = 3e-04 Identities = 27/94 (28%), Positives = 47/94 (50%) Frame = +1 Query: 382 MHYMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFGSTA 561 + Y+H ++H DLKP+N+L+ S +IK+ +I L + I+ + Sbjct: 564 LEYLHNYGIVHRDLKPDNLLITSMGHIKLTDF---GLSKIGLMSLTTNLYEGHIEKDARE 620 Query: 562 FDNQEHNSIVSTRHYRAPEIILGLGWSLPCDIWS 663 F +++ + T Y APE+IL G+ P D W+ Sbjct: 621 FLDKQ---VCGTPEYIAPEVILRQGYGKPVDWWA 651
>CDC2H_PLAKH (O96821) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 44.3 bits (103), Expect = 3e-04 Identities = 31/96 (32%), Positives = 47/96 (48%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 Y HE R++H DLKP+N+L+ N + E +K+ DFG + Sbjct: 115 YCHEHRVLHRDLKPQNLLI-------------NREGE-----------LKIADFGLARAF 150 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 +++ V T YRAP+I++G +S P DIWS Sbjct: 151 GIPVRKYTHEVVTLWYRAPDILMGSKKYSTPIDIWS 186
>CDC2H_PLACH (Q4Y4B1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 44.3 bits (103), Expect = 3e-04 Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 Y HE R++H DLKP+N+L+ N + E +K+ DFG + Sbjct: 115 YCHEHRVLHRDLKPQNLLI-------------NREGE-----------LKIADFGLARAF 150 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + + V T YRAP+I++G +S P DIWS Sbjct: 151 GIPARRYTHEVVTLWYRAPDILMGSKKYSTPIDIWS 186
>CDC2H_PLABA (Q4Z6R1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 44.3 bits (103), Expect = 3e-04 Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 4/96 (4%) Frame = +1 Query: 388 YMHELRLIHTDLKPENILLVSSEYIKVPSSKKNSQDEIHCKCLPKSSAIKLIDFG---ST 558 Y HE R++H DLKP+N+L+ N + E +K+ DFG + Sbjct: 115 YCHEHRVLHRDLKPQNLLI-------------NREGE-----------LKIADFGLARAF 150 Query: 559 AFDNQEHNSIVSTRHYRAPEIILG-LGWSLPCDIWS 663 + + V T YRAP+I++G +S P DIWS Sbjct: 151 GIPARRYTHEVVTLWYRAPDILMGSKKYSTPIDIWS 186 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 98,775,408 Number of Sequences: 219361 Number of extensions: 2265542 Number of successful extensions: 10839 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 8211 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 10034 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6427774254 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
