ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | basd14j24 |
|---|---|
| Clone Library Name | barley_pub |
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 151 bits (381), Expect = 2e-36 Identities = 85/178 (47%), Positives = 116/178 (65%), Gaps = 8/178 (4%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNS--YKGVEQFANEV 267 F+YEEL+ AT GF +++G G F V+KG+LRDG+VVAVKR K S K ++F NE+ Sbjct: 493 FSYEELEQATGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKRAIKASDVKKSSKEFHNEL 552 Query: 268 DILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLM---LSWPT 438 D+LSRL H +L+ L G + LLVYEF+ +G+L HLH G DP + L+W Sbjct: 553 DLLSRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLH-----GKDPNLKKRLNWAR 607 Query: 439 RLGIAVETAAALAYLHAH---QVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGAT 603 R+ IAV+ A + YLH + V+HRD+K++NIL+D + +VADFGLS L PAD T Sbjct: 608 RVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSILGPADSGT 665
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 139 bits (349), Expect = 9e-33 Identities = 88/186 (47%), Positives = 107/186 (57%), Gaps = 4/186 (2%) Frame = +1 Query: 73 GSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVE 249 G H F + EL AAT F LG GGFG VYKG L G VVAVK+L +N +G Sbjct: 67 GQIAAHTFAFRELAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGNR 126 Query: 250 QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLS 429 +F EV +LS L HPNLV L G + LLVYEF+P G+L DHLH D L Sbjct: 127 EFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPP---DKEALD 183 Query: 430 WPTRLGIAVETAAALAYLHAH---QVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGA 600 W R+ IA A L +LH V++RD K++NILLD G H K++DFGL++L P G Sbjct: 184 WNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLGPT-GD 242 Query: 601 TQHVST 618 HVST Sbjct: 243 KSHVST 248
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 136 bits (343), Expect = 4e-32 Identities = 78/174 (44%), Positives = 106/174 (60%), Gaps = 6/174 (3%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDI 273 FT E ++ AT+ + +G GGFG+VY+G L DG VAVK S +G +F NE+++ Sbjct: 585 FTLEYIELATEKYKTL--IGEGGFGSVYRGTLDDGQEVAVKVRSATSTQGTREFDNELNL 642 Query: 274 LSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPL---MLSWPTRL 444 LS ++H NLV L G + +LVY F+ NG+L D L+ G+P +L WPTRL Sbjct: 643 LSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLY------GEPAKRKILDWPTRL 696 Query: 445 GIAVETAAALAYLH---AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 IA+ A LAYLH V+HRDVK++NILLD + KVADFG S+ P +G Sbjct: 697 SIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDHSMCAKVADFGFSKYAPQEG 750
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 135 bits (341), Expect = 8e-32 Identities = 78/171 (45%), Positives = 105/171 (61%), Gaps = 3/171 (1%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDI 273 FT E ++ AT+ + +G GGFG+VY+G L DG VAVK S +G +F NE+++ Sbjct: 586 FTLEYIEQATEQYKTL--IGEGGFGSVYRGTLDDGQEVAVKVRSSTSTQGTREFDNELNL 643 Query: 274 LSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIA 453 LS ++H NLV L G + +LVY F+ NG+L D L +G A +L WPTRL IA Sbjct: 644 LSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRL-YGEA--SKRKILDWPTRLSIA 700 Query: 454 VETAAALAYLH---AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 + A LAYLH V+HRDVK++NILLD + KVADFG S+ P +G Sbjct: 701 LGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSMCAKVADFGFSKYAPQEG 751
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 135 bits (339), Expect = 1e-31 Identities = 85/199 (42%), Positives = 111/199 (55%), Gaps = 10/199 (5%) Frame = +1 Query: 52 RKEFNLAGSPCTHIF-------TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVA 210 RKE GS +F +Y++L +T+ F AN +G GGFG VYK L DG VA Sbjct: 701 RKELGEIGSKLVVLFQSNDKELSYDDLLDSTNSFDQANIIGCGGFGMVYKATLPDGKKVA 760 Query: 211 VKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLH 390 +K+L + + +F EV+ LSR +HPNLV L G D LL+Y ++ NG+L LH Sbjct: 761 IKKLSGDCGQIEREFEAEVETLSRAQHPNLVLLRGFCFYKNDRLLIYSYMENGSLDYWLH 820 Query: 391 HGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA---HQVLHRDVKTTNILLDGGLHVKVA 561 N G P +L W TRL IA A L YLH +LHRD+K++NILLD + +A Sbjct: 821 ERNDG---PALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLA 877 Query: 562 DFGLSRLFPADGATQHVST 618 DFGL+RL HVST Sbjct: 878 DFGLARLM--SPYETHVST 894
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 135 bits (339), Expect = 1e-31 Identities = 74/177 (41%), Positives = 111/177 (62%), Gaps = 3/177 (1%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T+ +L AT+GF + +G+GGFG VYK +L+DGS VA+K+L S +G +F E++ + Sbjct: 872 TFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETI 931 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 +++H NLV L G + LLVYEF+ G+L D LH G + L+W TR IA+ Sbjct: 932 GKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAG---VKLNWSTRRKIAI 988 Query: 457 ETAAALAYLH---AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 +A LA+LH + ++HRD+K++N+LLD L +V+DFG++RL A VST Sbjct: 989 GSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVST 1045
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 134 bits (338), Expect = 2e-31 Identities = 74/177 (41%), Positives = 110/177 (62%), Gaps = 3/177 (1%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T+ +L AT+GF + +G+GGFG VYK L+DGSVVA+K+L S +G +F E++ + Sbjct: 877 TFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETI 936 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 +++H NLV L G + LLVYE++ G+L D LH G + L+WP R IA+ Sbjct: 937 GKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKTG---IKLNWPARRKIAI 993 Query: 457 ETAAALAYLHAH---QVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 A LA+LH + ++HRD+K++N+LLD L +V+DFG++RL A VST Sbjct: 994 GAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVST 1050
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 134 bits (336), Expect = 3e-31 Identities = 75/171 (43%), Positives = 108/171 (63%), Gaps = 5/171 (2%) Frame = +1 Query: 91 IFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKN--SYKGVEQFANE 264 + + + L + T+ F + N LG+GGFG VYKG L DG+ +AVKR+ + KG +F +E Sbjct: 575 LISIQVLRSVTNNFSSDNILGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKGFAEFKSE 634 Query: 265 VDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRL 444 + +L+++RH +LV L G + LLVYE++P GTL+ HL + G PL+ W RL Sbjct: 635 IAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLL--WKQRL 692 Query: 445 GIAVETAAALAYLH--AHQ-VLHRDVKTTNILLDGGLHVKVADFGLSRLFP 588 +A++ A + YLH AHQ +HRD+K +NILL + KVADFGL RL P Sbjct: 693 TLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAP 743
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 134 bits (336), Expect = 3e-31 Identities = 74/177 (41%), Positives = 110/177 (62%), Gaps = 3/177 (1%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T+ +L AT+GF + +G+GGFG VYK L+DGSVVA+K+L S +G +F E++ + Sbjct: 877 TFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAEMETI 936 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 +++H NLV L G + LLVYE++ G+L D LH G + L+WP R IA+ Sbjct: 937 GKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKIG---IKLNWPARRKIAI 993 Query: 457 ETAAALAYLHAH---QVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 A LA+LH + ++HRD+K++N+LLD L +V+DFG++RL A VST Sbjct: 994 GAARGLAFLHHNCIPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVST 1050
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 132 bits (332), Expect = 8e-31 Identities = 79/170 (46%), Positives = 102/170 (60%), Gaps = 3/170 (1%) Frame = +1 Query: 118 ATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPN 297 ATD F N +G GGFGTVYK L VAVK+L + +G +F E++ L +++HPN Sbjct: 913 ATDHFSKKNIIGDGGFGTVYKACLPGEKTVAVKKLSEAKTQGNREFMAEMETLGKVKHPN 972 Query: 298 LVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALA 477 LV+L G S + LLVYE++ NG+L DH G + +L W RL IAV A LA Sbjct: 973 LVSLLGYCSFSEEKLLVYEYMVNGSL-DHWLRNQTGMLE--VLDWSKRLKIAVGAARGLA 1029 Query: 478 YLH---AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 +LH ++HRD+K +NILLDG KVADFGL+RL A HVST Sbjct: 1030 FLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLARLISA--CESHVST 1077
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 130 bits (327), Expect = 3e-30 Identities = 70/167 (41%), Positives = 102/167 (61%), Gaps = 3/167 (1%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 E + AT+ F + N+LG GGFG VYKG L DG +AVKRL K S +G ++F NEV +++R Sbjct: 519 ETVVKATENFSSCNKLGQGGFGIVYKGRLLDGKEIAVKRLSKTSVQGTDEFMNEVTLIAR 578 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+H NLV + GC + +L+YE++ N +L +L G L+W R I Sbjct: 579 LQHINLVQVLGCCIEGDEKMLIYEYLENLSLDSYLF----GKTRRSKLNWNERFDITNGV 634 Query: 463 AAALAYLH---AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 A L YLH +++HRD+K +NILLD + K++DFG++R+F D Sbjct: 635 ARGLLYLHQDSRFRIIHRDLKVSNILLDKNMIPKISDFGMARIFERD 681
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 130 bits (326), Expect = 4e-30 Identities = 83/204 (40%), Positives = 117/204 (57%), Gaps = 12/204 (5%) Frame = +1 Query: 43 TSLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRD--------- 195 T+ R E + SP FT+ EL AAT F + LG GGFG+V+KG + + Sbjct: 40 TNPRTEGEILQSPNLKSFTFAELKAATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPG 99 Query: 196 -GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGT 372 G V+AVK+L ++ ++G +++ EV+ L + HPNLV L G LLVYEF+P G+ Sbjct: 100 TGVVIAVKKLNQDGWQGHQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGS 159 Query: 373 LADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ--VLHRDVKTTNILLDGGL 546 L +HL G LSW RL +A+ A LA+LH + V++RD KT+NILLD Sbjct: 160 LENHLFR---RGSYFQPLSWTLRLKVALGAAKGLAFLHNAETSVIYRDFKTSNILLDSEY 216 Query: 547 HVKVADFGLSRLFPADGATQHVST 618 + K++DFGL++ P G HVST Sbjct: 217 NAKLSDFGLAKDGPT-GDKSHVST 239
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 129 bits (324), Expect = 7e-30 Identities = 72/177 (40%), Positives = 108/177 (61%), Gaps = 3/177 (1%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T+ L AT+GF A +G+GGFG VYK LRDGSVVA+K+L + + +G +F E++ + Sbjct: 848 TFAHLLEATNGFSAETMVGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGDREFMAEMETI 907 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 +++H NLV L G + LLVYE++ G+L LH ++ G + L+W R IA+ Sbjct: 908 GKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGG-IYLNWAARKKIAI 966 Query: 457 ETAAALAYLH---AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 A LA+LH ++HRD+K++N+LLD +V+DFG++RL A VST Sbjct: 967 GAARGLAFLHHSCIPHIIHRDMKSSNVLLDEDFEARVSDFGMARLVSALDTHLSVST 1023
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 129 bits (323), Expect = 9e-30 Identities = 72/176 (40%), Positives = 107/176 (60%), Gaps = 3/176 (1%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 + +L AT+GF AA+ +G GGFG V+K L+DGS VA+K+L + S +G +F E++ L Sbjct: 828 FSQLIEATNGFSAASMIGHGGFGEVFKATLKDGSSVAIKKLIRLSCQGDREFMAEMETLG 887 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 +++H NLV L G + LLVYEF+ G+L + L HG G +L W R IA Sbjct: 888 KIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVL-HGPRTGEKRRILGWEERKKIAKG 946 Query: 460 TAAALAYLHAH---QVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 A L +LH + ++HRD+K++N+LLD + +V+DFG++RL A VST Sbjct: 947 AAKGLCFLHHNCIPHIIHRDMKSSNVLLDQDMEARVSDFGMARLISALDTHLSVST 1002
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 128 bits (322), Expect = 1e-29 Identities = 72/177 (40%), Positives = 106/177 (59%), Gaps = 3/177 (1%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T+ L AT+GF A + +G+GGFG VYK L DGSVVA+K+L + + +G +F E++ + Sbjct: 847 TFAHLLEATNGFSADSMIGSGGFGDVYKAKLADGSVVAIKKLIQVTGQGDREFMAEMETI 906 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 +++H NLV L G + LLVYE++ G+L LH GG + L W R IA+ Sbjct: 907 GKIKHRNLVPLLGYCKIGEERLLVYEYMKYGSLETVLHEKTKKGG--IFLDWSARKKIAI 964 Query: 457 ETAAALAYLH---AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 A LA+LH ++HRD+K++N+LLD +V+DFG++RL A VST Sbjct: 965 GAARGLAFLHHSCIPHIIHRDMKSSNVLLDQDFVARVSDFGMARLVSALDTHLSVST 1021
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 128 bits (321), Expect = 2e-29 Identities = 80/180 (44%), Positives = 104/180 (57%), Gaps = 4/180 (2%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVE-QFANEVD 270 F+ EL A+D F N LG GGFG VYKG L DG++VAVKRL + +G E QF EV+ Sbjct: 277 FSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVE 336 Query: 271 ILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGI 450 ++S H NL+ L G + + LLVY ++ NG++A L L WP R I Sbjct: 337 MISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPP---LDWPKRQRI 393 Query: 451 AVETAAALAYLHAH---QVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVSTA 621 A+ +A LAYLH H +++HRDVK NILLD V DFGL++L D HV+TA Sbjct: 394 ALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLM--DYKDTHVTTA 451
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 128 bits (321), Expect = 2e-29 Identities = 78/196 (39%), Positives = 109/196 (55%), Gaps = 12/196 (6%) Frame = +1 Query: 67 LAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLR----------DGSVVAVK 216 L SP ++ + +L AT F + LG GGFG VY+G + G +VA+K Sbjct: 65 LLESPNLKVYNFLDLKTATKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIK 124 Query: 217 RLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHG 396 RL S +G ++ +EV+ L L H NLV L G ++LLLVYEF+P G+L HL Sbjct: 125 RLNSESVQGFAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRR 184 Query: 397 NAGGGDPLMLSWPTRLGIAVETAAALAYLHA--HQVLHRDVKTTNILLDGGLHVKVADFG 570 N DP W R+ I + A LA+LH+ +V++RD K +NILLD K++DFG Sbjct: 185 N----DP--FPWDLRIKIVIGAARGLAFLHSLQREVIYRDFKASNILLDSNYDAKLSDFG 238 Query: 571 LSRLFPADGATQHVST 618 L++L PAD HV+T Sbjct: 239 LAKLGPAD-EKSHVTT 253
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 126 bits (317), Expect = 5e-29 Identities = 78/179 (43%), Positives = 105/179 (58%), Gaps = 4/179 (2%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVD 270 FT++EL AT F + LG GGFG V+KG + VVA+K+L +N +G+ +F EV Sbjct: 91 FTFQELAEATGNFRSDCFLGEGGFGKVFKGTIEKLDQVVAIKQLDRNGVQGIREFVVEVL 150 Query: 271 ILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGI 450 LS HPNLV L G + LLVYE++P G+L DHLH +G L W TR+ I Sbjct: 151 TLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHVLPSG---KKPLDWNTRMKI 207 Query: 451 AVETAAALAYLHAHQ---VLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 A A L YLH V++RD+K +NILL K++DFGL+++ P+ G HVST Sbjct: 208 AAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSDFGLAKVGPS-GDKTHVST 265
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 125 bits (315), Expect = 8e-29 Identities = 78/184 (42%), Positives = 107/184 (58%), Gaps = 13/184 (7%) Frame = +1 Query: 88 HIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQ----- 252 H + E + A D N +G G G VYK LR G VVAVK+L K+ G ++ Sbjct: 670 HKLHFSEHEIA-DCLDEKNVIGFGSSGKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDS 728 Query: 253 -----FANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDP 417 FA EV+ L +RH ++V L+ C SS LLVYE++PNG+LAD LH GG Sbjct: 729 LNRDVFAAEVETLGTIRHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKGG--- 785 Query: 418 LMLSWPTRLGIAVETAAALAYLH---AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFP 588 ++L WP RL IA++ A L+YLH ++HRDVK++NILLD KVADFG++++ Sbjct: 786 VVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIAKVGQ 845 Query: 589 ADGA 600 G+ Sbjct: 846 MSGS 849
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 125 bits (315), Expect = 8e-29 Identities = 78/176 (44%), Positives = 103/176 (58%), Gaps = 4/176 (2%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +++ +T F AN +G GGFG VYK L DG+ VA+KRL ++ + +F EV+ LSR Sbjct: 734 DDILKSTSSFNQANIIGCGGFGLVYKATLPDGTKVAIKRLSGDTGQMDREFQAEVETLSR 793 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 +HPNLV L G + D LL+Y ++ NG+L LH G P L W TRL IA Sbjct: 794 AQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLHEKVDG---PPSLDWKTRLRIARGA 850 Query: 463 AAALAYLHAH---QVLHRDVKTTNILLDGGLHVKVADFGLSRL-FPADGATQHVST 618 A LAYLH +LHRD+K++NILL +ADFGL+RL P D HV+T Sbjct: 851 AEGLAYLHQSCEPHILHRDIKSSNILLSDTFVAHLADFGLARLILPYD---THVTT 903
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 125 bits (314), Expect = 1e-28 Identities = 74/174 (42%), Positives = 103/174 (59%), Gaps = 3/174 (1%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDI 273 F Y E+ T+ F +G GGFG VY GV+ +G VAVK L + S +G ++F EVD+ Sbjct: 564 FKYSEVVNITNNFERV--IGKGGFGKVYHGVI-NGEQVAVKVLSEESAQGYKEFRAEVDL 620 Query: 274 LSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIA 453 L R+ H NL +L G + ++L+YE++ N L D+L G +LSW RL I+ Sbjct: 621 LMRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYL-----AGKRSFILSWEERLKIS 675 Query: 454 VETAAALAYLH---AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQ 606 ++ A L YLH ++HRDVK TNILL+ L K+ADFGLSR F +G+ Q Sbjct: 676 LDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADFGLSRSFSVEGSGQ 729
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 122 bits (306), Expect = 9e-28 Identities = 80/178 (44%), Positives = 103/178 (57%), Gaps = 4/178 (2%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDI 273 ++Y EL AT F ELG G GTVYKGVL D VAVK+L +N +G E F E+ + Sbjct: 524 YSYRELVKATRKFKV--ELGRGESGTVYKGVLEDDRHVAVKKL-ENVRQGKEVFQAELSV 580 Query: 274 LSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIA 453 + R+ H NLV ++G S LLV E+V NG+LA+ L G ++L W R IA Sbjct: 581 IGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANILF----SEGGNILLDWEGRFNIA 636 Query: 454 VETAAALAYLHAHQ----VLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVS 615 + A LAYLH H+ V+H DVK NILLD K+ DFGL +L G+TQ+VS Sbjct: 637 LGVAKGLAYLH-HECLEWVIHCDVKPENILLDQAFEPKITDFGLVKLLNRGGSTQNVS 693
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 120 bits (300), Expect = 4e-27 Identities = 79/203 (38%), Positives = 115/203 (56%), Gaps = 12/203 (5%) Frame = +1 Query: 46 SLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRD---------- 195 S R E + SP F++ EL +AT F + LG GGFG V+KG + + Sbjct: 40 SPRTEGEILQSPNLKSFSFAELKSATRNFRPDSVLGEGGFGCVFKGWIDEKSLTASRPGT 99 Query: 196 GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTL 375 G V+AVK+L ++ ++G +++ EV+ L + H +LV L G LLVYEF+P G+L Sbjct: 100 GLVIAVKKLNQDGWQGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSL 159 Query: 376 ADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ--VLHRDVKTTNILLDGGLH 549 +HL G LSW RL +A+ A LA+LH+ + V++RD KT+NILLD + Sbjct: 160 ENHLFR---RGLYFQPLSWKLRLKVALGAAKGLAFLHSSETRVIYRDFKTSNILLDSEYN 216 Query: 550 VKVADFGLSRLFPADGATQHVST 618 K++DFGL++ P G HVST Sbjct: 217 AKLSDFGLAKDGPI-GDKSHVST 238
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 118 bits (296), Expect = 1e-26 Identities = 76/187 (40%), Positives = 106/187 (56%), Gaps = 12/187 (6%) Frame = +1 Query: 94 FTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGS----------VVAVKRLYKNSYKG 243 F+ EL +AT F + +G GGFG V+KG + + S V+AVKRL + ++G Sbjct: 56 FSLSELKSATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRLNQEGFQG 115 Query: 244 VEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLM 423 ++ E++ L +L HPNLV L G LLVYEF+ G+L +HL G Sbjct: 116 HREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFR---RGTFYQP 172 Query: 424 LSWPTRLGIAVETAAALAYLH--AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 LSW TR+ +A+ A LA+LH QV++RD K +NILLD + K++DFGL+R P G Sbjct: 173 LSWNTRVRMALGAARGLAFLHNAQPQVIYRDFKASNILLDSNYNAKLSDFGLARDGPM-G 231 Query: 598 ATQHVST 618 HVST Sbjct: 232 DNSHVST 238
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 116 bits (290), Expect = 6e-26 Identities = 68/174 (39%), Positives = 103/174 (59%), Gaps = 10/174 (5%) Frame = +1 Query: 88 HIFTYEELDAATDGF------GAANELGAGGFGTVYKGVLRDGSVVAVKRLYK----NSY 237 H F++ EL + T+ F N +G GGFG VYKG + + ++VAVK+L ++ Sbjct: 166 HSFSFHELKSITNNFDEQPASAGGNRMGEGGFGVVYKGCVNN-TIVAVKKLGAMVEISTE 224 Query: 238 KGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDP 417 + +QF E+ +++ +H NLV L G +S +L LVY ++PNG+L D L + G P Sbjct: 225 ELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRL---SCLDGTP 281 Query: 418 LMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 LSW TR +A TA + +LH + +HRD+K+ NILLD K++DFGL+R Sbjct: 282 -PLSWHTRCKVAQGTANGIRFLHENHHIHRDIKSANILLDKDFTAKISDFGLAR 334
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 113 bits (283), Expect = 4e-25 Identities = 72/177 (40%), Positives = 103/177 (58%), Gaps = 6/177 (3%) Frame = +1 Query: 106 ELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNS---YKGVEQ-FANEVDI 273 E+ T F ++G GGFG VY+ V+R+ +V AVKRL +N+ + V+Q F EV+ Sbjct: 204 EISRGTHNFSEELKIGEGGFGCVYRAVMRN-TVYAVKRLKENADLEWTAVKQSFLTEVEQ 262 Query: 274 LSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIA 453 LSR RHPN+V G + LVY F+PNG+L D LH LSWP RL I Sbjct: 263 LSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPP---LSWPQRLDIL 319 Query: 454 VETAAALAYLH--AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 + TA A+ +LH + ++H D+K++N+LLD L K+ DFGL+R G++ S+ Sbjct: 320 LGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSS 376
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 112 bits (280), Expect = 9e-25 Identities = 77/207 (37%), Positives = 114/207 (55%), Gaps = 8/207 (3%) Frame = +1 Query: 4 ASLDGLIREGSPLTSLRKEFNLAGSPCTHIFTYEELDAATDG----FGAANELGAGGFGT 171 A++ GLI + + K+ N S + +++LD ++ N +G GG G Sbjct: 647 AAITGLILISVAIRQMNKKKNQK-SLAWKLTAFQKLDFKSEDVLECLKEENIIGKGGAGI 705 Query: 172 VYKGVLRDGSVVAVKRLY-KNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLV 348 VY+G + + VA+KRL + + + F E+ L R+RH ++V L G ++ LL+ Sbjct: 706 VYRGSMPNNVDVAIKRLVGRGTGRSDHGFTAEIQTLGRIRHRHIVRLLGYVANKDTNLLL 765 Query: 349 YEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH---AHQVLHRDVKT 519 YE++PNG+L + L HG+ GG L W TR +AVE A L YLH + +LHRDVK+ Sbjct: 766 YEYMPNGSLGE-LLHGSKGG----HLQWETRHRVAVEAAKGLCYLHHDCSPLILHRDVKS 820 Query: 520 TNILLDGGLHVKVADFGLSRLFPADGA 600 NILLD VADFGL++ F DGA Sbjct: 821 NNILLDSDFEAHVADFGLAK-FLVDGA 846
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 111 bits (278), Expect = 2e-24 Identities = 68/174 (39%), Positives = 100/174 (57%), Gaps = 10/174 (5%) Frame = +1 Query: 88 HIFTYEELDAATDGFG------AANELGAGGFGTVYKGVLRDGSVVAVKRLYK----NSY 237 H F++ EL T+ F N++G GGFG VYKG + + + VAVK+L + Sbjct: 166 HSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNN-TTVAVKKLAAMVDITTE 224 Query: 238 KGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDP 417 + +QF E+ ++++ +H NLV L G +S DL LVY ++PNG+L D L + G P Sbjct: 225 ELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRL---SCLDGTP 281 Query: 418 LMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 LSW R IA A + +LH + +HRD+K+ NILLD K++DFGL+R Sbjct: 282 -PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLAR 334
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 110 bits (276), Expect = 3e-24 Identities = 74/195 (37%), Positives = 107/195 (54%), Gaps = 6/195 (3%) Frame = +1 Query: 34 SPLTSLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAV 213 SP++ L++ P + + E+ T F +G GGFG VY+ V+R+ + AV Sbjct: 185 SPVSGLQR-----AHPSPFCWPFCEISQGTCNFSEELRIGEGGFGCVYRAVMRN-TTYAV 238 Query: 214 KRLYKNS---YKGVEQ-FANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLAD 381 KRL + + + V+Q F EV+ LSR RHPN+V G + LVY F+PNG+L D Sbjct: 239 KRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLED 298 Query: 382 HLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH--AHQVLHRDVKTTNILLDGGLHVK 555 LH LSWP RL I + TA A+ +LH + ++H D+K++N+LLD L K Sbjct: 299 QLHLQTQACSP---LSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMPK 355 Query: 556 VADFGLSRLFPADGA 600 + DFGL+R GA Sbjct: 356 LGDFGLARFSRFAGA 370
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 99.0 bits (245), Expect = 1e-20 Identities = 59/166 (35%), Positives = 88/166 (53%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T + + + D +LGAG FG VY+G+ + + VAVK L + + F E I+ Sbjct: 84 TKDMWEISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTLKAGTMQPAA-FLAEAQIM 142 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 +LRHP L+ LY + + ++ E + G+L D+L G AG L P + +A Sbjct: 143 KKLRHPKLIQLYAVCTQGEPVYIITELMSKGSLLDYLQ-GEAGA-----LKLPQLIDMAA 196 Query: 457 ETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 + AA +AYL H +HRD+ NIL+ KVADFGL+RL +D Sbjct: 197 QVAAGMAYLELHNYIHRDLAARNILVGDNNICKVADFGLARLIVSD 242
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 98.2 bits (243), Expect = 2e-20 Identities = 60/159 (37%), Positives = 83/159 (52%), Gaps = 4/159 (2%) Frame = +1 Query: 118 ATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYK-GVEQFANEVDILSRLRHP 294 AT+ +G G GT+YK L V AVK+L K G E++ + ++RH Sbjct: 812 ATENLNDKYVIGKGAHGTIYKATLSPDKVYAVKKLVFTGIKNGSVSMVREIETIGKVRHR 871 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 NL+ L L++Y ++ NG+L D LH N P L W TR IAV TA L Sbjct: 872 NLIKLEEFWLRKEYGLILYTYMENGSLHDILHETNP----PKPLDWSTRHNIAVGTAHGL 927 Query: 475 AYLHAH---QVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 AYLH ++HRD+K NILLD L ++DFG+++L Sbjct: 928 AYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIAKL 966
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 97.8 bits (242), Expect = 2e-20 Identities = 65/171 (38%), Positives = 90/171 (52%), Gaps = 8/171 (4%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKN---SYKGVE--QFANE 264 Y EL+ ATDG+ N LG GGFG VY+G + V Y++ K VE Q NE Sbjct: 203 YAELENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNE 262 Query: 265 VDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRL 444 + L+ +RH N++ALYG + LVY+ + G+L L A P L+W R Sbjct: 263 LKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLP-ALTWQQRF 321 Query: 445 GIAVETAAALAYLHAHQ---VLHRDVKTTNILLDGGLHVKVADFGLSRLFP 588 I++ TA + +LH + ++H D+K NILLD L K+ DFGL R P Sbjct: 322 SISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGP 372
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 97.1 bits (240), Expect = 4e-20 Identities = 58/155 (37%), Positives = 84/155 (54%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LGAG FG V+ GV + + VAVK L K F +E ++ +LRH +LV LY S Sbjct: 245 KLGAGQFGEVWAGVWNNTTQVAVKTL-KPGTMSPASFLDEAGVMKKLRHKHLVQLYAICS 303 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D+L G + L PT + +A + A+ +A+L A +H Sbjct: 304 DREPIYIVTEYMSGGSLLDYLSKGEG-----VNLQLPTLIDMAAQVASGMAFLEAQGYIH 358 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 RD+ NIL+ KVADFGL+RL D T H Sbjct: 359 RDLAARNILVGENYICKVADFGLARLIEDDEYTAH 393
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 94.4 bits (233), Expect = 3e-19 Identities = 61/164 (37%), Positives = 88/164 (53%), Gaps = 4/164 (2%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKG--VEQFANEVDIL 276 +++D ++GAG FGTV++ GS VAVK L + + V +F EV I+ Sbjct: 542 DDMDIPWCDLNIKEKIGAGSFGTVHRAEWH-GSDVAVKILMEQDFHAERVNEFLREVAIM 600 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 RLRHPN+V G + +L +V E++ G+L LH A L RL +A Sbjct: 601 KRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGARE----QLDERRRLSMAY 656 Query: 457 ETAAALAYLHAHQ--VLHRDVKTTNILLDGGLHVKVADFGLSRL 582 + A + YLH ++HRD+K+ N+L+D VKV DFGLSRL Sbjct: 657 DVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRL 700
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 94.0 bits (232), Expect = 3e-19 Identities = 55/173 (31%), Positives = 86/173 (49%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 Y++ + ++LG G +G VY+GV + S+ + K VE+F E ++ Sbjct: 181 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 240 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 ++HPNLV L G + ++ EF+ G L D+L N + ++L L +A + Sbjct: 241 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVL-----LYMATQ 295 Query: 460 TAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 ++A+ YL +HRD+ N L+ VKVADFGLSRL D T H T Sbjct: 296 ISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGT 348
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 92.4 bits (228), Expect = 1e-18 Identities = 57/185 (30%), Positives = 95/185 (51%), Gaps = 3/185 (1%) Frame = +1 Query: 49 LRKEFNLAGSPCTHIFTYE---ELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKR 219 L + + A P T +Y+ E+D T +LG G FG V+ GV + VAVK Sbjct: 38 LSRPCSRANIPITSGLSYKDEWEIDRTT--IQLQRKLGQGNFGEVWAGVWNGTTAVAVKT 95 Query: 220 LYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGN 399 L ++ + V+ F E ++ ++ HPNL+ LY + + +V E + G++ ++L HG Sbjct: 96 LKPDTME-VKDFVQEAQVMKKIHHPNLLQLYAVCTIGEPIYIVTELMKYGSMLEYLKHGE 154 Query: 400 AGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 ++ + ++ + A+ + YL AH +HRD+ NIL+ G KVADFGL+R Sbjct: 155 GKN-----ITLHQMVDMSAQIASGMTYLEAHSYIHRDLAARNILVGEGNVCKVADFGLAR 209 Query: 580 LFPAD 594 + D Sbjct: 210 VIKED 214
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 92.0 bits (227), Expect = 1e-18 Identities = 56/150 (37%), Positives = 85/150 (56%), Gaps = 5/150 (3%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGS----VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVAL 309 ELG G FG VYKG L + VA+K L +N S K + F E++++S L+H N+V + Sbjct: 415 ELGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCI 474 Query: 310 YGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 G + +++E++ NG L + L + G L S L IA++ + + YL A Sbjct: 475 LGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSL--SQLEFLQIALQISEGMQYLSA 532 Query: 490 HQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 H +HRD+ N L++ GL VK++DFGLSR Sbjct: 533 HHYVHRDLAARNCLVNEGLVVKISDFGLSR 562
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 92.0 bits (227), Expect = 1e-18 Identities = 54/170 (31%), Positives = 85/170 (50%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 Y++ + ++LG G +G VY+GV + S+ + K VE+F E ++ Sbjct: 232 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 291 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 ++HPNLV L G + ++ EF+ G L D+L N + ++L L +A + Sbjct: 292 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVL-----LYMATQ 346 Query: 460 TAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 ++A+ YL +HRD+ N L+ VKVADFGLSRL D T H Sbjct: 347 ISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAH 396
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 91.7 bits (226), Expect = 2e-18 Identities = 54/170 (31%), Positives = 84/170 (49%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 Y++ + ++LG G +G VY+GV + S+ + K VE+F E ++ Sbjct: 118 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 177 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 ++HPNLV L G + ++ EF+ G L D+L N ++L L +A + Sbjct: 178 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVL-----LYMATQ 232 Query: 460 TAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 ++A+ YL +HRD+ N L+ VKVADFGLSRL D T H Sbjct: 233 ISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAH 282
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 91.7 bits (226), Expect = 2e-18 Identities = 54/170 (31%), Positives = 84/170 (49%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 Y++ + ++LG G +G VY+GV + S+ + K VE+F E ++ Sbjct: 232 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 291 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 ++HPNLV L G + ++ EF+ G L D+L N ++L L +A + Sbjct: 292 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVL-----LYMATQ 346 Query: 460 TAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 ++A+ YL +HRD+ N L+ VKVADFGLSRL D T H Sbjct: 347 ISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAH 396
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 91.7 bits (226), Expect = 2e-18 Identities = 54/156 (34%), Positives = 80/156 (51%) Frame = +1 Query: 142 NELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCT 321 ++LG G +G VY GV + S+ + K VE+F E ++ ++HPNLV L G Sbjct: 292 HKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVC 351 Query: 322 SSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVL 501 + +V E++P G L D+L N ++L L +A + ++A+ YL + Sbjct: 352 TLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVL-----LYMATQISSAMEYLEKKNFI 406 Query: 502 HRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 HRD+ N L+ VKVADFGLSRL D T H Sbjct: 407 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH 442
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 89.7 bits (221), Expect = 6e-18 Identities = 51/150 (34%), Positives = 84/150 (56%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG+G FG V++G+ + + VA+K L K+ + F E I+ +LRH L+ LY + Sbjct: 253 KLGSGQFGDVWEGLWNNTTPVAIKTL-KSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCT 311 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + ++ E + +G+L ++L A G L T + +A + AA +AYL + +H Sbjct: 312 VEEPIYIITELMKHGSLLEYLQ---AIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIH 368 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 RD+ N+L+ G VK+ADFGL+RL D Sbjct: 369 RDLAARNVLVGDGNIVKIADFGLARLIKED 398
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 89.7 bits (221), Expect = 6e-18 Identities = 56/169 (33%), Positives = 83/169 (49%) Frame = +1 Query: 76 SPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQF 255 +P T + + A D +LG G F V+ G + VA+K L K E F Sbjct: 249 TPQTSGLAKDAWEVARDSLFLEKKLGQGCFAEVWLGTWNGNTKVAIKTL-KPGTMSPESF 307 Query: 256 ANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWP 435 E I+ +L+H LV LY S + +V E++ G+L D L G L P Sbjct: 308 LEEAQIMKKLKHDKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKDGEGRA-----LKLP 361 Query: 436 TRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 + +A + AA +AY+ +HRD+++ NIL+ GL K+ADFGL+RL Sbjct: 362 NLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARL 410
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 89.7 bits (221), Expect = 6e-18 Identities = 59/161 (36%), Positives = 78/161 (48%), Gaps = 3/161 (1%) Frame = +1 Query: 115 AATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHP 294 A D F A ++GAG F VYK R V V ++ K EV +++RLRHP Sbjct: 47 ARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLP-SNRSNTLREVQLMNRLRHP 105 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N++ G L + E++ GTL L P LSWP RL +A++ A L Sbjct: 106 NILRFMGVCVHQGQLHALTEYMNGGTLEQLL-------SSPEPLSWPVRLHLALDIAQGL 158 Query: 475 AYLHAHQVLHRDVKTTNILL---DGGLHVKVADFGLSRLFP 588 YLHA V HRD+ + N L+ DGG V DFGL+ P Sbjct: 159 RYLHAKGVFHRDLTSKNCLVRREDGGFTAVVGDFGLAEKIP 199
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 89.4 bits (220), Expect = 8e-18 Identities = 57/146 (39%), Positives = 76/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VAVK L K E F E I+ RLRH LV LY S Sbjct: 274 KLGNGQFGEVWMGTWNGTTKVAVKTL-KPGTMSPEAFLEEAQIMKRLRHDKLVQLYAVVS 332 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G D L P + +A + AA +AY+ +H Sbjct: 333 E-EPIYIVTEFMSQGSLLDFLKDG-----DGRYLKLPQLVDMAAQIAAGMAYIERMNYIH 386 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L K+ADFGL+RL Sbjct: 387 RDLRAANILVGDNLVCKIADFGLARL 412
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 89.0 bits (219), Expect = 1e-17 Identities = 54/160 (33%), Positives = 83/160 (51%), Gaps = 2/160 (1%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 ELG+G FG V +G R GS+ ++ K + F E ++++L+HPNLV LYG S Sbjct: 531 ELGSGQFGVVRRGKWR-GSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCS 589 Query: 325 SCRDLLLVYEFVPNGTLADHL--HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 R + +V E++ +G+L ++L H G L+L + ++ + + YL H Sbjct: 590 KHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLD------MCIQVSKGMTYLERHNY 643 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 +HRD+ N L+ VKVADFGL+R D T T Sbjct: 644 IHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGT 683
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 88.6 bits (218), Expect = 1e-17 Identities = 55/155 (35%), Positives = 87/155 (56%), Gaps = 6/155 (3%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVV----AVKRLYKNSY-KGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + +G V A+K L + + K +F +E I++ + HP+LV L Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRL 783 Query: 310 YGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 G S + LV + +P+G L +++H G L+L+W V+ A + YL Sbjct: 784 LGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNW------CVQIAKGMMYLEE 836 Query: 490 HQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 +++HRD+ N+L+ HVK+ DFGL+RL D Sbjct: 837 RRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGD 871
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 88.6 bits (218), Expect = 1e-17 Identities = 54/157 (34%), Positives = 80/157 (50%) Frame = +1 Query: 112 DAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRH 291 + A D +LG G F V++G + VA+K L K E F E I+ +L+H Sbjct: 261 EVARDSLFLEQKLGQGCFAEVWRGTWNGNTKVAIKTL-KPGTMSPESFLEEAQIMKKLKH 319 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 LV LY S R + +V E++ G+L L G L P + +A + AA Sbjct: 320 DKLVQLYAVVSR-RPIYIVTEYMSKGSLLIFLKDGEGRA-----LKLPNLVDMAAQVAAG 373 Query: 472 LAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 +AY+ +HRD+++ NIL+ GL K+ADFGL+RL Sbjct: 374 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARL 410
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 88.6 bits (218), Expect = 1e-17 Identities = 53/145 (36%), Positives = 76/145 (52%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LG G FG V+ G + VA+K L K E F E I+ +L+H LV LY S Sbjct: 276 LGNGQFGEVWMGTWNGNTKVAIKTL-KPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE 334 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V E++ G+L D L G L P + +A + AA +AY+ +HR Sbjct: 335 -EPIYIVTEYMNKGSLLDFLKDGEGRA-----LKLPNLVDMAAQVAAGMAYIERMNYIHR 388 Query: 508 DVKTTNILLDGGLHVKVADFGLSRL 582 D+++ NIL+ GL K+ADFGL+RL Sbjct: 389 DLRSANILVGNGLICKIADFGLARL 413
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 88.2 bits (217), Expect = 2e-17 Identities = 54/153 (35%), Positives = 85/153 (55%), Gaps = 3/153 (1%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKN--SYKGVEQFANEVDILSRLRHPNL 300 + ++ +G G FG VYK +D S VVA+K + K + K ++ E DI +RL+HP++ Sbjct: 4 YAVSSLVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHV 63 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 + + S DL +V EF L +L + A G +P + +AL Y Sbjct: 64 IEMIESFESKTDLFVVTEFALMD-LHRYLSYNGAMGEEPARR-------VTGHLVSALYY 115 Query: 481 LHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 LH++++LHRD+K N+LLD +H K+ DFGL+R Sbjct: 116 LHSNRILHRDLKPQNVLLDKNMHAKLCDFGLAR 148
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 88.2 bits (217), Expect = 2e-17 Identities = 56/149 (37%), Positives = 91/149 (61%), Gaps = 4/149 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLY-KNSYKGVEQ-FANEVDILSRLRHPNLVALYGCT 321 LG GG+G VYK + + G+ VAVK + K+ K +E+ F EV I++ LRHPN+V + Sbjct: 792 LGTGGYGEVYKSIWK-GTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAAS 850 Query: 322 SSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGI--AVETAAALAYLHAHQ 495 + ++ +V EF+ G+L D L G+ L+ P L I A + + + +LH+ Sbjct: 851 TKSPNMCIVMEFMSLGSLYDLL-------GNELIPEIPYALKIKMAYQASKGMHFLHSSG 903 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRL 582 ++HRD+K+ N+LLD +VKV+DFGL+++ Sbjct: 904 IVHRDLKSLNLLLDSKWNVKVSDFGLTKV 932 Score = 79.3 bits (194), Expect = 8e-15 Identities = 51/178 (28%), Positives = 89/178 (50%), Gaps = 4/178 (2%) Frame = +1 Query: 61 FNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYK 240 F + + C I Y+E+ ++G G +G V+ G + G VAVK+ K Sbjct: 1348 FLTSANMCRWIINYDEISIG-------KQIGLGSYGIVFNGKWK-GVDVAVKKFVKQKLS 1399 Query: 241 GVE--QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGD 414 + +F E+ LS L+H N+V G ++ +V E++ G L D L + + Sbjct: 1400 ETQLLEFRAEMAFLSELKHSNIVTFIGACIKKPNICIVTEYMRMGNLRDVLKNPD----- 1454 Query: 415 PLMLSWPTRLGIAVETAAALAYLHAHQ--VLHRDVKTTNILLDGGLHVKVADFGLSRL 582 + +++ +L + A + YLH+ ++HRD+K NIL+D +VK+ADFG +R+ Sbjct: 1455 -IKITFANKLKLLYGAAMGIDYLHSSNPMIVHRDIKPANILVDEHFNVKIADFGFARI 1511
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 88.2 bits (217), Expect = 2e-17 Identities = 55/155 (35%), Positives = 87/155 (56%), Gaps = 6/155 (3%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVV----AVKRLYKNSY-KGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + +G V A+K L + + K +F +E I++ + HP+LV L Sbjct: 724 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRL 783 Query: 310 YGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 G S + LV + +P+G L +++H G L+L+W V+ A + YL Sbjct: 784 LGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNW------CVQIAKGMMYLEE 836 Query: 490 HQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 +++HRD+ N+L+ HVK+ DFGL+RL D Sbjct: 837 RRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGD 871
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 88.2 bits (217), Expect = 2e-17 Identities = 58/182 (31%), Positives = 87/182 (47%), Gaps = 2/182 (1%) Frame = +1 Query: 40 LTSLRKEFNLAGS--PCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAV 213 ++ LR L GS P T F+YE+ + E+G+G FG V+ G R VA+ Sbjct: 239 ISRLRYPIGLLGSCLPATSGFSYEKWEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAI 298 Query: 214 KRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHH 393 K + + S E F E ++ +L H LV LYG + L +V EF+ NG L D+L Sbjct: 299 KAINEGSMSE-EDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRE 357 Query: 394 GNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGL 573 L+LS + + +AYL +HRD+ N L+ VK++DFG+ Sbjct: 358 RKGQLQKALLLS------MCQDICEGMAYLERSCYIHRDLAARNCLVSSACVVKISDFGM 411 Query: 574 SR 579 +R Sbjct: 412 AR 413
>WIS4_SCHPO (O14299) MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase| kinase kinase wak1) (MAP kinase kinase kinase wik1) Length = 1401 Score = 87.8 bits (216), Expect = 2e-17 Identities = 58/166 (34%), Positives = 84/166 (50%), Gaps = 8/166 (4%) Frame = +1 Query: 154 AGGFGTVYKGV-LRDGSVVAVKRLYKNSYKG----VEQFANEVDILSRLRHPNLVALYGC 318 +G FG VY GV + G ++AVK + + V+Q NE+ +L RL HPN+V YG Sbjct: 1045 SGMFGDVYTGVNMETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNHPNVVTYYGV 1104 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + + EF G+LAD L HG + L + V+ LAY+H+ + Sbjct: 1105 EVHREKVYIFMEFCQGGSLADLLAHGRIEDENVLKV-------YVVQLLEGLAYIHSQHI 1157 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSRLF---PADGATQHVSTAPQ 627 LHRD+K NILLD +K +DFG S L+ P D ++ P+ Sbjct: 1158 LHRDIKPANILLDHRGMIKYSDFG-SALYVSPPTDPEVRYEDIQPE 1202
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 87.8 bits (216), Expect = 2e-17 Identities = 56/157 (35%), Positives = 82/157 (52%), Gaps = 1/157 (0%) Frame = +1 Query: 142 NELGAGGFGTVYKGVL-RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 ++LG G +G VY+ V R G+ VAVK L K ++ F E I+ ++HPNLV L G Sbjct: 375 HKLGGGQYGEVYEAVWKRYGNTVAVKTL-KEDTMALKDFLEEAAIMKEMKHPNLVQLIGV 433 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + ++ EF+ +G L D L D + L L +A + A+ ++YL + Sbjct: 434 CTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVAL-----LYMATQIASGMSYLESRNY 488 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 +HRD+ N L+ VKVADFGL+RL D T H Sbjct: 489 IHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAH 525
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 87.8 bits (216), Expect = 2e-17 Identities = 51/145 (35%), Positives = 79/145 (54%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LGAG FG V++G+ + VAVK L K +E+F E I+ +LRHP L+ LY + Sbjct: 246 LGAGQFGEVWEGLWNGTTSVAVKTL-KPGTMSIEEFLEEASIMKQLRHPKLIQLYAVCTK 304 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V E + +G+L ++L GD L P + + + A+ ++YL +HR Sbjct: 305 EEPIYIVTELMKHGSLLEYLR------GDGRSLKLPDLVDMCSQVASGMSYLEQQNYIHR 358 Query: 508 DVKTTNILLDGGLHVKVADFGLSRL 582 D+ NIL+ KVADFGL+R+ Sbjct: 359 DLAARNILVGEHKICKVADFGLARV 383
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 87.0 bits (214), Expect = 4e-17 Identities = 54/155 (34%), Positives = 79/155 (50%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVAL 309 F +LG G FG V++G+ VA+K + K++ + A E+ L LRH L+ L Sbjct: 230 FALGRKLGEGYFGEVWEGLWLGSLPVAIK-VIKSANMKLTDLAKEIQTLKGLRHERLIRL 288 Query: 310 YGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 + S + +V E + G L L G + L P LG A + A ++YL Sbjct: 289 HAVCSGGEPVYIVTELMRKGNLQAFL-----GTPEGRALRLPPLLGFACQVAEGMSYLEE 343 Query: 490 HQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 +V+HRD+ N+L+D GL KVADFGL+RL D Sbjct: 344 QRVVHRDLAARNVLVDDGLACKVADFGLARLLKDD 378
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 87.0 bits (214), Expect = 4e-17 Identities = 54/145 (37%), Positives = 75/145 (51%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LG G FG V+ G + VAVK L K E F E I+ +LRH LV LY S Sbjct: 276 LGNGQFGEVWMGTWNGTTKVAVKTL-KPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSE 334 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V E++ G+L D L G L P + +A + AA +AY+ +HR Sbjct: 335 -EPIYIVTEYMSKGSLLDFLKDGEGRA-----LKLPNLVDMAAQVAAGMAYIERMNYIHR 388 Query: 508 DVKTTNILLDGGLHVKVADFGLSRL 582 D+++ NIL+ L K+ADFGL+RL Sbjct: 389 DLRSANILVGDNLVCKIADFGLARL 413
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 87.0 bits (214), Expect = 4e-17 Identities = 52/145 (35%), Positives = 75/145 (51%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LG G FG V+ G + VA+K L K E F E I+ +L+H LV LY S Sbjct: 276 LGNGQFGEVWMGTWNGNTKVAIKTL-KPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSE 334 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V E++ G+L D L G L P + +A + A +AY+ +HR Sbjct: 335 -EPIYIVTEYMSKGSLLDFLKDGEGRA-----LKLPNLVDMAAQVARGMAYIERMNYIHR 388 Query: 508 DVKTTNILLDGGLHVKVADFGLSRL 582 D+++ NIL+ GL K+ADFGL+RL Sbjct: 389 DLRSANILVGNGLICKIADFGLARL 413
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 86.7 bits (213), Expect = 5e-17 Identities = 56/182 (30%), Positives = 87/182 (47%), Gaps = 2/182 (1%) Frame = +1 Query: 40 LTSLRKEFNLAGS--PCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAV 213 +T LR L GS P T F+YE+ + E+G+G FG V+ G R VA+ Sbjct: 239 MTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAI 298 Query: 214 KRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHH 393 K + + S E F E ++ +L H LV LYG + L +V EF+ NG L ++L Sbjct: 299 KAINEGSMSE-EDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE 357 Query: 394 GNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGL 573 ++LS + + + YL + +HRD+ N L+ VK++DFG+ Sbjct: 358 NKGKLRKEMLLS------VCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGM 411 Query: 574 SR 579 +R Sbjct: 412 TR 413
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 86.7 bits (213), Expect = 5e-17 Identities = 58/161 (36%), Positives = 77/161 (47%), Gaps = 3/161 (1%) Frame = +1 Query: 115 AATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHP 294 A D F A ++GAG F VYK R V V ++ K EV +++RLRHP Sbjct: 47 ARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLP-SNRSNTLREVQLMNRLRHP 105 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N++ G L + E++ GTL L P LSWP RL +A++ A L Sbjct: 106 NILRFMGVCVHQGQLHALTEYMNGGTLEQLL-------SSPEPLSWPVRLHLALDIAQGL 158 Query: 475 AYLHAHQVLHRDVKTTNILL---DGGLHVKVADFGLSRLFP 588 YLHA V HRD+ + N L+ D G V DFGL+ P Sbjct: 159 RYLHAKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIP 199
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 86.3 bits (212), Expect = 7e-17 Identities = 52/145 (35%), Positives = 79/145 (54%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LGAG FG V++G+ + VAVK L K VE+F E I+ RLRHP L+ LY + Sbjct: 246 LGAGQFGEVWEGLWNGTTSVAVKTL-KPGTMSVEEFLQEASIMKRLRHPKLIQLYAVCTK 304 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V E + G+L ++L G+ +L + +A + A+ ++YL +HR Sbjct: 305 EEPIYIVTELMKYGSLLEYLR------GEDGVLKIEQLVDVAAQVASGMSYLEQQNYIHR 358 Query: 508 DVKTTNILLDGGLHVKVADFGLSRL 582 D+ NIL+ KVADFGL+R+ Sbjct: 359 DLAARNILVGEHGICKVADFGLARV 383
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 86.3 bits (212), Expect = 7e-17 Identities = 50/158 (31%), Positives = 81/158 (51%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 E+G+G FG V+ G + VA+K + + + E F E +++ +L HP LV LYG Sbjct: 373 EIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSE-EDFIEEAEVMMKLSHPKLVQLYGVCL 431 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + LV+EF+ +G L+D+L + + T LG+ ++ +AYL V+H Sbjct: 432 EQAPICLVFEFMEHGCLSDYLRSQRG------LFAAETLLGMCLDVCEGMAYLEKACVIH 485 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 RD+ N L+ +KV+DFG++R D T T Sbjct: 486 RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGT 523
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 86.3 bits (212), Expect = 7e-17 Identities = 51/158 (32%), Positives = 81/158 (51%) Frame = +1 Query: 139 ANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 + +G+G FGTVYKG V + ++ + + + F NEV +L + RH N++ G Sbjct: 85 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 144 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +L +V ++ +L HLH + IA +TA + YLHA + Sbjct: 145 MTK-DNLAIVTQWCEGSSLYKHLHVQET------KFQMFQLIDIARQTAQGMDYLHAKNI 197 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHV 612 +HRD+K+ NI L GGL VK+ DFGL+ + +Q V Sbjct: 198 IHRDMKSNNIFLHGGLTVKIGDFGLATVKSRWSGSQQV 235
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 85.9 bits (211), Expect = 9e-17 Identities = 58/159 (36%), Positives = 84/159 (52%), Gaps = 14/159 (8%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + S + F E ++L+ L+H ++V Sbjct: 515 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVR 574 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGN-----AGGGD--PLMLSWPTRLGIAVET 462 +G + R LL+V+E++ +G L L HG AGG D P L L +A + Sbjct: 575 FFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQV 634 Query: 463 AAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 AA + YL +HRD+ T N L+ GL VK+ DFG+SR Sbjct: 635 AAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR 673
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 85.9 bits (211), Expect = 9e-17 Identities = 56/159 (35%), Positives = 82/159 (51%), Gaps = 1/159 (0%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 ELG+G FG V G + VAVK + + S ++F E + +L HP LV YG S Sbjct: 422 ELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSE-DEFFQEAQTMMKLSHPKLVKFYGVCS 480 Query: 325 SCRDLLLVYEFVPNGTLADHLH-HGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVL 501 + +V E++ NG L ++L HG G +P L L + + +A+L +HQ + Sbjct: 481 KEYPIYIVTEYISNGCLLNYLRSHGK--GLEPSQL-----LEMCYDVCEGMAFLESHQFI 533 Query: 502 HRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 HRD+ N L+D L VKV+DFG++R D V T Sbjct: 534 HRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGT 572
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 85.9 bits (211), Expect = 9e-17 Identities = 59/162 (36%), Positives = 80/162 (49%), Gaps = 4/162 (2%) Frame = +1 Query: 115 AATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYK-NSYKGVEQFANEVDILSRLRH 291 A D F A ++GAG F VYK R V V ++ K S +G EV +++RLRH Sbjct: 52 ARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRG--NTLREVQLMNRLRH 109 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ G L + E++ GTL L P LSWP RL +A++ A Sbjct: 110 PNILRFMGVCVHQGQLHALTEYMNGGTLEQLL-------SSPEPLSWPVRLHLALDIARG 162 Query: 472 LAYLHAHQVLHRDVKTTNILL---DGGLHVKVADFGLSRLFP 588 L YLH+ V HRD+ + N L+ D G V DFGL+ P Sbjct: 163 LRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIP 204
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 85.5 bits (210), Expect = 1e-16 Identities = 50/158 (31%), Positives = 81/158 (51%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 E+G+G FG V+ G + VA+K + + + E F E +++ +L HP LV LYG Sbjct: 368 EIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSE-EDFIEEAEVMMKLSHPKLVQLYGVCL 426 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + LV+EF+ +G L+D+L + + T LG+ ++ +AYL V+H Sbjct: 427 EQAPICLVFEFMEHGCLSDYLRTQRG------LFAAETLLGMCLDVCEGMAYLEEACVIH 480 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 RD+ N L+ +KV+DFG++R D T T Sbjct: 481 RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGT 518
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 85.5 bits (210), Expect = 1e-16 Identities = 56/150 (37%), Positives = 80/150 (53%), Gaps = 6/150 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSY---KGVEQFANEVDILSRLRHPNLVALYG- 315 +G+G FG VYKG R+ +VA+KR N+Y V+ F EV IL +L HP +V G Sbjct: 467 IGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGA 525 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA-- 489 C +V +++ G+L LH +L ++L IAV+ A + YLH+ Sbjct: 526 CLDDPSQFAIVTQYISGGSLFSLLHEQKR------ILDLQSKLIIAVDVAKGMEYLHSLT 579 Query: 490 HQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 ++HRD+ + NILL H VADFG SR Sbjct: 580 QPIIHRDLNSHNILLYEDGHAVVADFGESR 609
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 85.5 bits (210), Expect = 1e-16 Identities = 49/146 (33%), Positives = 78/146 (53%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LGAG FG V+ G + + VAVK L K V+ F E +++ L+H LV LY + Sbjct: 251 KLGAGQFGEVWMGYYNNSTKVAVKTL-KPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVT 309 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + ++ EF+ G+L D L GG L+ P + + + A +AY+ +H Sbjct: 310 KEEPIYIITEFMAKGSLLDFLKSDE--GGKVLL---PKLIDFSAQIAEGMAYIERKNYIH 364 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ N+L+ L K+ADFGL+R+ Sbjct: 365 RDLRAANVLVSESLMCKIADFGLARV 390
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 85.5 bits (210), Expect = 1e-16 Identities = 56/150 (37%), Positives = 80/150 (53%), Gaps = 6/150 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSY---KGVEQFANEVDILSRLRHPNLVALYG- 315 +G+G FG VYKG R+ +VA+KR N+Y V+ F EV IL +L HP +V G Sbjct: 468 IGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGA 526 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA-- 489 C +V +++ G+L LH +L ++L IAV+ A + YLH+ Sbjct: 527 CLDDPSQFAIVTQYISGGSLFSLLHEQKR------ILDLQSKLIIAVDVAKGMEYLHSLT 580 Query: 490 HQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 ++HRD+ + NILL H VADFG SR Sbjct: 581 QPIIHRDLNSHNILLYEDGHAVVADFGESR 610
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 85.1 bits (209), Expect = 2e-16 Identities = 51/150 (34%), Positives = 77/150 (51%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G R+ VAVK L + + F E I+ + RH LVALY S Sbjct: 289 KLGRGNFGEVFYGKWRNSIDVAVKTLREGTMS-TAAFLQEAAIMKKFRHNRLVALYAVCS 347 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G D L + + IA + A+ + YL + Q++H Sbjct: 348 QEEPIYIVQEYMSKGSLLDFLREG-----DGRYLHFEDLIYIATQVASGMEYLESKQLIH 402 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 RD+ N+L+ K+ DFGL+R+ D Sbjct: 403 RDLAARNVLIGENNVAKICDFGLARVIADD 432
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 85.1 bits (209), Expect = 2e-16 Identities = 55/150 (36%), Positives = 80/150 (53%), Gaps = 6/150 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSY---KGVEQFANEVDILSRLRHPNLVALYG- 315 +G+G FG VYKG R+ +VA+KR N+Y V+ F EV IL +L HP ++ G Sbjct: 570 IGSGSFGKVYKGRCRN-KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGA 628 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH--A 489 C + +V +++ G+L LH +L ++L IAV+ A + YLH Sbjct: 629 CLNDPSQFAIVTQYISGGSLFSLLHEQKR------ILDLQSKLIIAVDVAKGMEYLHNLT 682 Query: 490 HQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 ++HRD+ + NILL H VADFG SR Sbjct: 683 QPIIHRDLNSHNILLYEDGHAVVADFGESR 712
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 84.7 bits (208), Expect = 2e-16 Identities = 64/184 (34%), Positives = 89/184 (48%), Gaps = 7/184 (3%) Frame = +1 Query: 64 NLAGSPCTHIFTYEELDAATDGFGAANE-------LGAGGFGTVYKGVLRDGSVVAVKRL 222 NL +PCT I + L A D + + LG G FG V+ G + VAVK L Sbjct: 235 NLLIAPCT-IMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTL 293 Query: 223 YKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNA 402 K + F E ++ LRH LV LY S + +V EF+ +G+L D L N Sbjct: 294 -KPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSE-EPIYIVTEFMCHGSLLDFLK--NP 349 Query: 403 GGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 G D L P + +A + A +AY+ +HRD++ NIL+ L K+ADFGL+RL Sbjct: 350 EGQD---LRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARL 406 Query: 583 FPAD 594 D Sbjct: 407 IKDD 410
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 84.3 bits (207), Expect = 3e-16 Identities = 54/146 (36%), Positives = 75/146 (51%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 281 KLGQGCFGEVWMGTWNGTTKVAIKTL-KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS 339 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G D L P + +A + A +AY+ +H Sbjct: 340 E-EPIYIVTEFMSKGSLLDFLKEG-----DGKYLKLPQLVDMAAQIADGMAYIERMNYIH 393 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L K+ADFGL+RL Sbjct: 394 RDLRAANILVGENLVCKIADFGLARL 419
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 84.3 bits (207), Expect = 3e-16 Identities = 56/155 (36%), Positives = 78/155 (50%), Gaps = 4/155 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRLRH 291 D F LG G FG VY L++ +VA+K L+K+ + G+E Q E++I + L+H Sbjct: 41 DDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQH 100 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LY R + L+ E+ P G L L L I E A A Sbjct: 101 PNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK-------LDEQRTATIIEELADA 153 Query: 472 LAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLS 576 L Y H +V+HRD+K N+LL VK+ADFG S Sbjct: 154 LTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWS 188
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 84.3 bits (207), Expect = 3e-16 Identities = 54/146 (36%), Positives = 75/146 (51%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 279 KLGQGCFGEVWMGTWNGTTKVAIKTL-KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS 337 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G D L P + +A + A +AY+ +H Sbjct: 338 E-EPIYIVTEFMSKGSLLDFLKEG-----DGKYLKLPQLVDMAAQIADGMAYIERMNYIH 391 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L K+ADFGL+RL Sbjct: 392 RDLRAANILVGENLICKIADFGLARL 417
>ROR1_HUMAN (Q01973) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) Length = 937 Score = 84.0 bits (206), Expect = 3e-16 Identities = 57/168 (33%), Positives = 88/168 (52%), Gaps = 18/168 (10%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLR-----DGSVVAVKRL--YKNSYKGVEQFANEVDILSRLRHPNLV 303 ELG FG +YKG L +VA+K L Y N + +E F E +++ L HPN+V Sbjct: 478 ELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWME-FQQEASLMAELHHPNIV 536 Query: 304 ALYGCTSSCRDLLLVYEFVPNGTLADHL----HHGNAG------GGDPLMLSWPTRLGIA 453 L G + + + +++E++ G L + L H + G G L L IA Sbjct: 537 CLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIA 596 Query: 454 VETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR-LFPAD 594 ++ AA + YL +H +H+D+ NIL+ LHVK++D GLSR ++ AD Sbjct: 597 IQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSAD 644
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 84.0 bits (206), Expect = 3e-16 Identities = 50/158 (31%), Positives = 81/158 (51%) Frame = +1 Query: 139 ANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 + +G+G FGTVYKG V + ++ + + ++ F NEV +L + RH N++ G Sbjct: 352 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 411 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +L +V ++ +L HLH + IA +TA + YLHA + Sbjct: 412 MTK-DNLAIVTQWCEGSSLYKHLHVQET------KFQMFQLIDIARQTAQGMDYLHAKNI 464 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHV 612 +HRD+K+ NI L GL VK+ DFGL+ + +Q V Sbjct: 465 IHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV 502
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 84.0 bits (206), Expect = 3e-16 Identities = 50/158 (31%), Positives = 81/158 (51%) Frame = +1 Query: 139 ANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 + +G+G FGTVYKG V + ++ + + ++ F NEV +L + RH N++ G Sbjct: 352 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 411 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +L +V ++ +L HLH + IA +TA + YLHA + Sbjct: 412 MTK-DNLAIVTQWCEGSSLYKHLHVQET------KFQMFQLIDIARQTAQGMDYLHAKNI 464 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHV 612 +HRD+K+ NI L GL VK+ DFGL+ + +Q V Sbjct: 465 IHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV 502
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 84.0 bits (206), Expect = 3e-16 Identities = 53/158 (33%), Positives = 76/158 (48%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 ELG G FG V G + VAVK + K ++F E + +L HP LV YG S Sbjct: 398 ELGNGQFGVVQLGQWKGQYDVAVKMI-KEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCS 456 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ NG L ++L G L L + + +A+L +HQ +H Sbjct: 457 KKYPIYIVTEYITNGCLLNYLKSHGKG------LESCQLLEMCYDVCEGMAFLESHQFIH 510 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 RD+ N L+D L VKV+DFG++R D V T Sbjct: 511 RDLAARNCLVDSDLSVKVSDFGMTRYVLDDQYVSSVGT 548
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 84.0 bits (206), Expect = 3e-16 Identities = 57/159 (35%), Positives = 84/159 (52%), Gaps = 14/159 (8%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + S + F E ++L+ L+H ++V Sbjct: 518 ELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVR 577 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGN-----AGGGD--PLMLSWPTRLGIAVET 462 +G + LL+V+E++ +G L L HG AGG D P L L +A + Sbjct: 578 FFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQV 637 Query: 463 AAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 AA + YL + +HRD+ T N L+ GL VK+ DFG+SR Sbjct: 638 AAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSR 676
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 84.0 bits (206), Expect = 3e-16 Identities = 49/175 (28%), Positives = 87/175 (49%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 +++ + + F +LG+G FG V++G+ +D VA+K + +++ + +E+ + Sbjct: 181 WDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMK 240 Query: 280 RLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVE 459 +LRH +++ALY S + ++ E + G+L + L D +L L IA + Sbjct: 241 KLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLR-----DSDEKVLPVSELLDIAWQ 295 Query: 460 TAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVSTAP 624 A + YL + +HRD+ NIL+ KV DFGL+RL D H P Sbjct: 296 VAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIP 350
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 84.0 bits (206), Expect = 3e-16 Identities = 50/158 (31%), Positives = 81/158 (51%) Frame = +1 Query: 139 ANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 + +G+G FGTVYKG V + ++ + + ++ F NEV +L + RH N++ G Sbjct: 27 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 86 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +L +V ++ +L HLH + IA +TA + YLHA + Sbjct: 87 MTK-DNLAIVTQWCEGSSLYKHLHVQET------KFQMFQLIDIARQTAQGMDYLHAKNI 139 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHV 612 +HRD+K+ NI L GL VK+ DFGL+ + +Q V Sbjct: 140 IHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV 177
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 84.0 bits (206), Expect = 3e-16 Identities = 54/146 (36%), Positives = 75/146 (51%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 277 KLGQGCFGEVWMGTWNGTTKVAIKTL-KLGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS 335 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G D L P + +A + A +AY+ +H Sbjct: 336 E-EPIYIVTEFMSKGSLLDFLKEG-----DGKYLKLPQLVDMAAQIADGMAYIERMNYIH 389 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L K+ADFGL+RL Sbjct: 390 RDLRAANILVGENLVCKIADFGLARL 415
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 83.6 bits (205), Expect = 4e-16 Identities = 53/146 (36%), Positives = 74/146 (50%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 279 KLGQGCFGEVWMGTWNGTTKVAIKTL-KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS 337 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G L P + +A + A +AY+ +H Sbjct: 338 E-EPIYIVTEFMTKGSLLDFLKEGEGK-----FLKLPQLVDMAAQIADGMAYIERMNYIH 391 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L K+ADFGL+RL Sbjct: 392 RDLRAANILVGDNLVCKIADFGLARL 417
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 83.6 bits (205), Expect = 4e-16 Identities = 66/192 (34%), Positives = 92/192 (47%), Gaps = 18/192 (9%) Frame = +1 Query: 73 GSPCTHI----FTYEELDAATDGFGAANE---------LGAGGFGTVYKGVLRDGSV--- 204 GSP I FTYE+ + A F + +GAG FG VYKG L+ S Sbjct: 588 GSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPSKREI 647 Query: 205 -VAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLA 378 VA+K L S K F +E I+ + HPN++ L G + R ++++ EF+ NG L Sbjct: 648 SVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD 707 Query: 379 DHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKV 558 L N G + L +G+ AA + YL +HRD+ NIL++ L KV Sbjct: 708 SFLRQ-NDGQFTVIQL-----VGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKV 761 Query: 559 ADFGLSRLFPAD 594 +DFGLSR D Sbjct: 762 SDFGLSRYLQDD 773
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 83.6 bits (205), Expect = 4e-16 Identities = 54/164 (32%), Positives = 82/164 (50%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + F +LG G FG V++G+ VAVK + K++ + E++ L Sbjct: 225 DEWERPRSEFVLRRKLGEGFFGEVWEGLWLGSIPVAVK-VIKSADMKLADLTKEIEALKS 283 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 LRH L+ L+ S + +V E + G L +L G + LS P LG A + Sbjct: 284 LRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYL-----GSSEGKALSLPHLLGFACQV 338 Query: 463 AAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 A ++YL +V+HRD+ N+L+ L KVADFGL+RL D Sbjct: 339 AEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLKDD 382
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 83.6 bits (205), Expect = 4e-16 Identities = 66/192 (34%), Positives = 92/192 (47%), Gaps = 18/192 (9%) Frame = +1 Query: 73 GSPCTHI----FTYEELDAATDGFGAANE---------LGAGGFGTVYKGVLRDGSV--- 204 GSP I FTYE+ + A F + +GAG FG VYKG L+ S Sbjct: 505 GSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPSKREI 564 Query: 205 -VAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLA 378 VA+K L S K F +E I+ + HPN++ L G + R ++++ EF+ NG L Sbjct: 565 SVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD 624 Query: 379 DHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKV 558 L N G + L +G+ AA + YL +HRD+ NIL++ L KV Sbjct: 625 SFLRQ-NDGQFTVIQL-----VGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKV 678 Query: 559 ADFGLSRLFPAD 594 +DFGLSR D Sbjct: 679 SDFGLSRYLQDD 690
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 83.6 bits (205), Expect = 4e-16 Identities = 48/145 (33%), Positives = 77/145 (53%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LGAG FG V+ G + + VAVK L K V+ F E +++ L+H LV LY + Sbjct: 252 LGAGQFGEVWMGYYNNSTKVAVKTL-KPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTR 310 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + ++ E++ G+L D L GG L+ P + + + A +AY+ +HR Sbjct: 311 EEPIYIITEYMAKGSLLDFLKSDE--GGKVLL---PKLIDFSAQIAEGMAYIERKNYIHR 365 Query: 508 DVKTTNILLDGGLHVKVADFGLSRL 582 D++ N+L+ L K+ADFGL+R+ Sbjct: 366 DLRAANVLVSESLMCKIADFGLARV 390
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 83.6 bits (205), Expect = 4e-16 Identities = 56/196 (28%), Positives = 96/196 (48%) Frame = +1 Query: 25 REGSPLTSLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSV 204 RE +P++ +++ + Y E++A+ + +G+G FGTVYKG Sbjct: 316 RERAPVSGTQEKNKIRPRGQRDSSYYWEIEASE--VMLSTRIGSGSFGTVYKGKWHGDVA 373 Query: 205 VAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADH 384 V + ++ + + + F NEV +L + RH N++ G + +L +V ++ +L H Sbjct: 374 VKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTK-DNLAIVTQWCEGSSLYKH 432 Query: 385 LHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVAD 564 LH + IA +TA + YLHA ++HRD+K+ NI L GL VK+ D Sbjct: 433 LHVQET------KFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGD 486 Query: 565 FGLSRLFPADGATQHV 612 FGL+ + +Q V Sbjct: 487 FGLATVKSRWSGSQQV 502
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 83.6 bits (205), Expect = 4e-16 Identities = 57/196 (29%), Positives = 96/196 (48%) Frame = +1 Query: 25 REGSPLTSLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSV 204 RE +P T+ +++ + Y E++A+ + +G+G FGTVYKG Sbjct: 316 RERAPGTNTQEKNKIRPRGQRDSSYYWEIEASE--VMLSTRIGSGSFGTVYKGKWHGDVA 373 Query: 205 VAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADH 384 V + ++ + + + F NEV +L + RH N++ G + +L +V ++ +L H Sbjct: 374 VKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTK-DNLAIVTQWCEGSSLYKH 432 Query: 385 LHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVAD 564 LH + IA +TA + YLHA ++HRD+K+ NI L GL VK+ D Sbjct: 433 LHVQET------KFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGD 486 Query: 565 FGLSRLFPADGATQHV 612 FGL+ + +Q V Sbjct: 487 FGLATVKSRWSGSQQV 502
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 83.2 bits (204), Expect = 6e-16 Identities = 54/166 (32%), Positives = 87/166 (52%), Gaps = 6/166 (3%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGV------EQFANE 264 EE A N+ +G +Y+G+ + +V AVK + ++K +QF +E Sbjct: 77 EEWTADLSQLFIGNKFASGAHSRIYRGIYKQRAV-AVKMVRIPTHKEETRAKLEQQFKSE 135 Query: 265 VDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRL 444 V +LSRL HPN+V ++ E++ G L +L+ +P LS T L Sbjct: 136 VALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKK-----EPYSLSIETVL 190 Query: 445 GIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 +A++ + + YLH+ V+HRD+K+ N+LL+ + VKVADFG S L Sbjct: 191 RLALDISRGMEYLHSQGVIHRDLKSNNLLLNDEMRVKVADFGTSCL 236
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 83.2 bits (204), Expect = 6e-16 Identities = 47/146 (32%), Positives = 78/146 (53%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LGAG FG V+ G + + VAVK L K + F E +++ L+H LV LY + Sbjct: 251 KLGAGQFGEVWMGYYNNSTKVAVKTL-KPGTMSAQAFLEEANLMKTLQHDKLVRLYAVVT 309 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + ++ EF+ G+L D L + G ++L P + + + A +AY+ +H Sbjct: 310 KEEPIYIITEFMAKGSLLDFL---KSDEGSKVLL--PKLIDFSAQIAEGMAYIERKNYIH 364 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ N+L+ L K+ADFGL+R+ Sbjct: 365 RDLRAANVLVSESLMCKIADFGLARV 390
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 83.2 bits (204), Expect = 6e-16 Identities = 53/154 (34%), Positives = 82/154 (53%), Gaps = 4/154 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLYKNSYKG---VEQFANEVDILSRLRHPNLVALYG 315 +G G FG V +G ++ G VA+K L + KG V + NE+D L +L HP++ L+ Sbjct: 30 IGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTHPHITRLFR 89 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 S+ D+ LV E V G L ++ G P+ S + + ++Y H H Sbjct: 90 VISTPSDIFLVMELVSGGELFSYI---TRKGALPIRES----RRYFQQIISGVSYCHNHM 142 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 ++HRD+K N+LLD ++K+ADFGLS + DG Sbjct: 143 IVHRDLKPENLLLDANKNIKIADFGLSN-YMTDG 175
>ERBB2_MESAU (Q60553) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) Length = 1254 Score = 83.2 bits (204), Expect = 6e-16 Identities = 59/163 (36%), Positives = 89/163 (54%), Gaps = 9/163 (5%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGS----VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + DG VA+K L +N S K ++ +E +++ L P + L Sbjct: 726 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGLGSPYVSRL 785 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHL--HHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 G C +S + LV + +P G L DH+ H G G D +L+W V+ A ++Y Sbjct: 786 LGICLTST--VQLVTQLMPYGCLLDHVREHRGRLGSQD--LLNW------CVQIAKGMSY 835 Query: 481 LHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 L +++HRD+ N+L+ HVK+ DFGL+RL D H Sbjct: 836 LEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYH 878
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 83.2 bits (204), Expect = 6e-16 Identities = 54/146 (36%), Positives = 77/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G D + VA+K L K E F E ++ +LRH LV LY S Sbjct: 271 KLGQGCFGEVWMGTWNDTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 329 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G G L P + +A + A+ +AY+ +H Sbjct: 330 E-EPIYIVIEYMSKGSLLDFLK-GEMGK----YLRLPQLVDMAAQIASGMAYVERMNYVH 383 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 384 RDLRAANILVGENLVCKVADFGLARL 409
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 83.2 bits (204), Expect = 6e-16 Identities = 50/160 (31%), Positives = 81/160 (50%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + + +LGAG FG V+ G + VA+K L + S F E +++ Sbjct: 234 DEWEVPRESLKLVEKLGAGQFGEVWMGFYNGHTKVAIKNLKQGSMSP-SAFLAEANLMKN 292 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+HP LV LY + + ++ E++ G+L D L + LS L +A + Sbjct: 293 LQHPRLVRLYAVVTK-EPIYIITEYMEKGSLVDFLKTSEG-----IKLSINKLLDMAAQI 346 Query: 463 AAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 A +A++ A +HRD++ NIL+ L K+ADFGL+RL Sbjct: 347 AEGMAFIEAKNYIHRDLRAANILVSEALCCKIADFGLARL 386
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 83.2 bits (204), Expect = 6e-16 Identities = 53/146 (36%), Positives = 74/146 (50%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 272 KLGQGCFGEVWMGTWNGTTKVAIKTL-KLGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS 330 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G L P + +A + A +AY+ +H Sbjct: 331 E-EPIYIVTEFMTKGSLLDFLKEGEGK-----FLKLPQLVDMAAQIADGMAYIERMNYIH 384 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L K+ADFGL+RL Sbjct: 385 RDLRAANILVGDNLVCKIADFGLARL 410
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 82.8 bits (203), Expect = 8e-16 Identities = 50/158 (31%), Positives = 83/158 (52%) Frame = +1 Query: 139 ANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 ++ +G+G FGTVYKG V + ++ + + ++ F NEV +L + RH N++ G Sbjct: 343 SSRIGSGSFGTVYKGKWHGDVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGY 402 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +L +V ++ +L HLH + + IA +TA + YLHA + Sbjct: 403 MTK-DNLAIVTQWCEGSSLYYHLHVLDT------KFQMFQLIDIARQTAQGMDYLHAKNI 455 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHV 612 +HRD+K+ NI L GL VK+ DFGL+ + +Q V Sbjct: 456 IHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQV 493
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 82.8 bits (203), Expect = 8e-16 Identities = 50/166 (30%), Positives = 87/166 (52%) Frame = +1 Query: 97 TYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDIL 276 T ++ + + LG+G FG V++G+ + + VAVK L S F E I+ Sbjct: 223 TVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDP-NDFLREAQIM 281 Query: 277 SRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAV 456 LRHP L+ LY + + ++ E + +G+L ++L + G + L+ ++ +A Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDT---GSKIHLT--QQVDMAA 336 Query: 457 ETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 + A+ +AYL + +HRD+ N+L+ KVADFGL+R+F D Sbjct: 337 QVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVD 382
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 82.8 bits (203), Expect = 8e-16 Identities = 50/160 (31%), Positives = 83/160 (51%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + + LGAG FG V+ G + VAVK L + S + F E +++ + Sbjct: 235 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSP-DAFLAEANLMKQ 293 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+HP LV LY + + ++ E++ NG+L D L + + L+ L +A + Sbjct: 294 LQHPRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSG-----IKLNVNKLLDMAAQI 347 Query: 463 AAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 A +A++ +HRD++ NIL+ L K+ADFGL+RL Sbjct: 348 AEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARL 387
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 82.8 bits (203), Expect = 8e-16 Identities = 53/146 (36%), Positives = 75/146 (51%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 275 KLGQGCFGEVWIGTWNGTTKVAIKTL-KPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS 333 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L GN L P + +A + A +AY+ +H Sbjct: 334 E-EPIYIVTEYMIKGSLLDFLKEGNGK-----YLKLPQLVDMAAQIADGMAYIERMNYIH 387 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L K+ADFGL+RL Sbjct: 388 RDLRAANILVGDNLVCKIADFGLARL 413
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 82.8 bits (203), Expect = 8e-16 Identities = 50/163 (30%), Positives = 85/163 (52%), Gaps = 4/163 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFAN---EVDILSRLRHPNLVALYG 315 LG G +G V + R G VVA+K + K+ K + + E++I+S L HP+++++Y Sbjct: 61 LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYE 120 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 + ++++ E+ G L D++ + LS + +A+ Y H + Sbjct: 121 VFENKDKIVIIMEYASKGELYDYI-------SERRRLSERETRHFFRQIVSAVHYCHKNG 173 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVSTAP 624 V+HRD+K NILLD ++K+ADFGLS L+ D Q +P Sbjct: 174 VVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSP 216
>ERBB2_MOUSE (P70424) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) Length = 1256 Score = 82.4 bits (202), Expect = 1e-15 Identities = 58/163 (35%), Positives = 89/163 (54%), Gaps = 9/163 (5%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGS----VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + DG VA+K L +N S K ++ +E +++ + P + L Sbjct: 727 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRL 786 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHL--HHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 G C +S + LV + +P G L DH+ H G G D +L+W V+ A ++Y Sbjct: 787 LGICLTST--VQLVTQLMPYGCLLDHVREHRGRLGSQD--LLNW------CVQIAKGMSY 836 Query: 481 LHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 L +++HRD+ N+L+ HVK+ DFGL+RL D H Sbjct: 837 LEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYH 879
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 82.4 bits (202), Expect = 1e-15 Identities = 65/192 (33%), Positives = 91/192 (47%), Gaps = 18/192 (9%) Frame = +1 Query: 73 GSPCTHI----FTYEELDAATDGFGAANE---------LGAGGFGTVYKGVLRDGS---- 201 GSP I FTYE+ + A F + +GAG FG VYKG L+ Sbjct: 587 GSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREI 646 Query: 202 VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLA 378 VA+K L S K F +E I+ + HPN++ L G + R ++++ EF+ NG L Sbjct: 647 YVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD 706 Query: 379 DHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKV 558 L N G + L +G+ AA + YL +HRD+ NIL++ L KV Sbjct: 707 SFLRQ-NDGQFTVIQL-----VGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKV 760 Query: 559 ADFGLSRLFPAD 594 +DFGLSR D Sbjct: 761 SDFGLSRYLQDD 772
>BLK_MOUSE (P16277) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 498 Score = 82.4 bits (202), Expect = 1e-15 Identities = 50/179 (27%), Positives = 86/179 (48%) Frame = +1 Query: 88 HIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEV 267 +++ +E + +LG+G FG V+ G ++ VA+K L K E F E Sbjct: 220 NLWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTL-KEGTMSPEAFLGEA 278 Query: 268 DILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLG 447 +++ L+H LV LY + + +V E++ G L D L LS P + Sbjct: 279 NVMKTLQHERLVRLYAVVTR-EPIYIVTEYMARGCLLDFLKTDEGS-----RLSLPRLID 332 Query: 448 IAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVSTAP 624 ++ + A +AY+ +HRD++ NIL+ L K+ADFGL+R+ ++ Q + P Sbjct: 333 MSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKFP 391
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 82.4 bits (202), Expect = 1e-15 Identities = 50/160 (31%), Positives = 83/160 (51%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + + LGAG FG V+ G D + VAVK L + S + F E +++ + Sbjct: 235 DEWEVPRETLKLVERLGAGQFGEVWMGYYNDHTKVAVKSLKQGSMSP-DAFLAEANLMKQ 293 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+H LV LY + + ++ E++ NG+L D L + + L+ L +A + Sbjct: 294 LQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSG-----IKLTINKLLDMAAQI 347 Query: 463 AAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 A +A++ +HRD++ NIL+ L K+ADFGL+RL Sbjct: 348 AEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARL 387
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 82.4 bits (202), Expect = 1e-15 Identities = 55/157 (35%), Positives = 80/157 (50%), Gaps = 12/157 (7%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L S + F E ++L+ L+H ++V Sbjct: 542 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 601 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGN-----AGGGDPLMLSWPTRLGIAVETAA 468 YG L++V+E++ +G L L HG A G P L+ L IA + AA Sbjct: 602 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAA 661 Query: 469 ALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 + YL + +HRD+ T N L+ L VK+ DFG+SR Sbjct: 662 GMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 698
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 82.4 bits (202), Expect = 1e-15 Identities = 55/157 (35%), Positives = 80/157 (50%), Gaps = 12/157 (7%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L S + F E ++L+ L+H ++V Sbjct: 542 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 601 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGN-----AGGGDPLMLSWPTRLGIAVETAA 468 YG L++V+E++ +G L L HG A G P L+ L IA + AA Sbjct: 602 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAA 661 Query: 469 ALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 + YL + +HRD+ T N L+ L VK+ DFG+SR Sbjct: 662 GMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 698
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 82.4 bits (202), Expect = 1e-15 Identities = 55/157 (35%), Positives = 80/157 (50%), Gaps = 12/157 (7%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L S + F E ++L+ L+H ++V Sbjct: 543 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 602 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGN-----AGGGDPLMLSWPTRLGIAVETAA 468 YG L++V+E++ +G L L HG A G P L+ L IA + AA Sbjct: 603 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAA 662 Query: 469 ALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 + YL + +HRD+ T N L+ L VK+ DFG+SR Sbjct: 663 GMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 699
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 82.4 bits (202), Expect = 1e-15 Identities = 53/157 (33%), Positives = 86/157 (54%), Gaps = 7/157 (4%) Frame = +1 Query: 145 ELGAGGFGTVYK---GVLRD--GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVAL 309 +LG G FG+V L+D G VVAVK+L ++ + + F E++IL L+H N+V Sbjct: 854 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKY 913 Query: 310 YGCTSSC--RDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 G S R+L L+ E++P G+L D+L +L + +++ +E YL Sbjct: 914 KGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGME------YL 967 Query: 484 HAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 + +HRD+ T NIL++ VK+ DFGL+++ P D Sbjct: 968 GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD 1004 Score = 54.3 bits (129), Expect = 3e-07 Identities = 49/176 (27%), Positives = 80/176 (45%), Gaps = 17/176 (9%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD--------GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLV 303 LG G F ++KGV R+ + V +K L K E F ++S+L H +LV Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLV 610 Query: 304 ALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 YG + +LV EFV G+L +L + + + W +LG+A + A A+ +L Sbjct: 611 LNYGVCVCGEENILVQEFVKFGSLDTYLKKNK----NSINILW--KLGVAKQLAWAMHFL 664 Query: 484 HAHQVLHRDVKTTNILL--------DGGLHVKVADFGLS-RLFPADGATQHVSTAP 624 ++H +V NILL +K++D G+S + P D + + P Sbjct: 665 EEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDILQERIPWVP 720
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 82.4 bits (202), Expect = 1e-15 Identities = 53/157 (33%), Positives = 86/157 (54%), Gaps = 7/157 (4%) Frame = +1 Query: 145 ELGAGGFGTVYK---GVLRD--GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVAL 309 +LG G FG+V L+D G VVAVK+L ++ + + F E++IL L+H N+V Sbjct: 854 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKY 913 Query: 310 YGCTSSC--RDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 G S R+L L+ E++P G+L D+L +L + +++ +E YL Sbjct: 914 KGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGME------YL 967 Query: 484 HAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 + +HRD+ T NIL++ VK+ DFGL+++ P D Sbjct: 968 GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD 1004 Score = 54.3 bits (129), Expect = 3e-07 Identities = 49/176 (27%), Positives = 80/176 (45%), Gaps = 17/176 (9%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD--------GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLV 303 LG G F ++KGV R+ + V +K L K E F ++S+L H +LV Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLV 610 Query: 304 ALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 YG + +LV EFV G+L +L + + + W +LG+A + A A+ +L Sbjct: 611 LNYGVCVCGEENILVQEFVKFGSLDTYLKKNK----NSINILW--KLGVAKQLAWAMHFL 664 Query: 484 HAHQVLHRDVKTTNILL--------DGGLHVKVADFGLS-RLFPADGATQHVSTAP 624 ++H +V NILL +K++D G+S + P D + + P Sbjct: 665 EEKSLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP 720
>LIMK1_DROME (Q8IR79) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (dLIMK)| Length = 1257 Score = 82.0 bits (201), Expect = 1e-15 Identities = 50/147 (34%), Positives = 79/147 (53%), Gaps = 2/147 (1%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCT 321 +LG G FG V+K R G V+ +K L++ + F EV +L L H +++ G Sbjct: 406 KLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVL 465 Query: 322 SSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPL-MLSWPTRLGIAVETAAALAYLHAHQV 498 + L +V E+V G L + +H DP +L WP R+ +A + A ++YLH+ + Sbjct: 466 YKDKKLHMVTEYVAGGCLKELIH-------DPAQVLPWPQRVRLARDIACGMSYLHSMNI 518 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSR 579 +HRD+ + N L+ V VADFGL+R Sbjct: 519 IHRDLNSMNCLVREDRSVIVADFGLAR 545
>ERBB2_RAT (P06494) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Epidermal growth factor receptor-related protein) Length = 1257 Score = 82.0 bits (201), Expect = 1e-15 Identities = 58/163 (35%), Positives = 89/163 (54%), Gaps = 9/163 (5%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGS----VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + DG VA+K L +N S K ++ +E +++ + P + L Sbjct: 728 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRL 787 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHL--HHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 G C +S + LV + +P G L DH+ H G G D +L+W V+ A ++Y Sbjct: 788 LGICLTST--VQLVTQLMPYGCLLDHVREHRGRLGSQD--LLNW------CVQIAKGMSY 837 Query: 481 LHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 L +++HRD+ N+L+ HVK+ DFGL+RL D H Sbjct: 838 LEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYH 880
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 82.0 bits (201), Expect = 1e-15 Identities = 53/157 (33%), Positives = 80/157 (50%), Gaps = 1/157 (0%) Frame = +1 Query: 142 NELGAGGFGTVYKGV-LRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGC 318 N+LG G +G VY+G R +AVK L K + +F E I+ L H NLV L G Sbjct: 315 NKLGGGQYGDVYEGYWKRHDCTIAVKAL-KEDAMPLHEFLAEAAIMKDLHHKNLVRLLGV 373 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + ++ EF+ NG L ++L + P++L + +A + A+ ++YL A Sbjct: 374 CTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIIL-----VQMASQIASGMSYLEARHF 428 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 +HRD+ N L+ VK+ADFGL+R D T H Sbjct: 429 IHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAH 465
>ROR1_MOUSE (Q9Z139) Tyrosine-protein kinase transmembrane receptor ROR1| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1) Length = 937 Score = 82.0 bits (201), Expect = 1e-15 Identities = 57/168 (33%), Positives = 87/168 (51%), Gaps = 18/168 (10%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLR-----DGSVVAVKRL--YKNSYKGVEQFANEVDILSRLRHPNLV 303 ELG FG +YKG L +VA+K L Y N + E F E +++ L HPN+V Sbjct: 478 ELGECTFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTE-FQQEASLMAELHHPNIV 536 Query: 304 ALYGCTSSCRDLLLVYEFVPNGTLADHL----HHGNAG------GGDPLMLSWPTRLGIA 453 L G + + + +++E++ G L + L H + G G L L IA Sbjct: 537 CLLGAVTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIA 596 Query: 454 VETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR-LFPAD 594 ++ AA + YL +H +H+D+ NIL+ LHVK++D GLSR ++ AD Sbjct: 597 IQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSAD 644
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 82.0 bits (201), Expect = 1e-15 Identities = 50/153 (32%), Positives = 83/153 (54%), Gaps = 9/153 (5%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLY--------KNSYKGVEQFANEVDILSRLRHPNL 300 +G G FGTVY G+ L G ++AVK++ + + +++ EV +L L HPN+ Sbjct: 74 IGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPNI 133 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 V G L ++ EFVP G+++ L A + ++ ++ +L + +E Y Sbjct: 134 VRYLGTVREDETLNILLEFVPGGSISSLLEKFGAFP-ESVVRTYTNQLLLGLE------Y 186 Query: 481 LHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 LH H ++HRD+K NIL+D +K+ADFG S+ Sbjct: 187 LHNHAIMHRDIKGANILVDNQGCIKLADFGASK 219
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 82.0 bits (201), Expect = 1e-15 Identities = 53/145 (36%), Positives = 74/145 (51%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LG G FG V+ G + VA+K L K E F E I+ +LRH LV LY S Sbjct: 283 LGQGCFGEVWMGTWNGTTKVAIKTL-KPGTMSPEAFLEEAQIMKKLRHDKLVPLYAVVSE 341 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V EF+ G+L D L G D L P + +A + A +A++ +HR Sbjct: 342 -EPIYIVTEFMGKGSLLDFLKEG-----DGKHLKLPQLVDMASQIADGMAFIERMNYIHR 395 Query: 508 DVKTTNILLDGGLHVKVADFGLSRL 582 D++ NIL+ L K+ADFGL+RL Sbjct: 396 DLRAANILVADNLVCKIADFGLARL 420
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 82.0 bits (201), Expect = 1e-15 Identities = 55/157 (35%), Positives = 80/157 (50%), Gaps = 12/157 (7%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L S + F E ++L+ L+H ++V Sbjct: 539 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVK 598 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGN-----AGGGDPLMLSWPTRLGIAVETAA 468 YG L++V+E++ +G L L HG A G P L+ L IA + AA Sbjct: 599 FYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQIAA 658 Query: 469 ALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 + YL + +HRD+ T N L+ L VK+ DFG+SR Sbjct: 659 GMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 695
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 82.0 bits (201), Expect = 1e-15 Identities = 58/178 (32%), Positives = 92/178 (51%), Gaps = 5/178 (2%) Frame = +1 Query: 43 TSLRKEFNLAGSPCTHIFTYE-ELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKR 219 TS+ K+ L +F E ++ ATD F ++ G F VY+G R G K+ Sbjct: 180 TSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGH-RHGKPFVFKK 238 Query: 220 LYK---NSYKGVEQFAN-EVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHL 387 L + +S +E+F E+ I R HPN++ + G ++ + +Y ++ NG+L D L Sbjct: 239 LRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRL 298 Query: 388 HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVA 561 GG DPL WP R+ I A+ YLH +++H +VK++N+LLD L K+A Sbjct: 299 Q--GQGGSDPL--PWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLA 352
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 82.0 bits (201), Expect = 1e-15 Identities = 65/192 (33%), Positives = 91/192 (47%), Gaps = 18/192 (9%) Frame = +1 Query: 73 GSPCTHI----FTYEELDAATDGFGAANE---------LGAGGFGTVYKGVLRDGS---- 201 GSP I FTYE+ + A F + +GAG FG VYKG L+ Sbjct: 587 GSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREI 646 Query: 202 VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLA 378 VA+K L S K F +E I+ + HPN++ L G + R ++++ EF+ NG L Sbjct: 647 YVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD 706 Query: 379 DHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKV 558 L N G + L +G+ AA + YL +HRD+ NIL++ L KV Sbjct: 707 SFLRQ-NDGQFTVIQL-----VGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKV 760 Query: 559 ADFGLSRLFPAD 594 +DFGLSR D Sbjct: 761 SDFGLSRYLQDD 772
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 82.0 bits (201), Expect = 1e-15 Identities = 65/192 (33%), Positives = 91/192 (47%), Gaps = 18/192 (9%) Frame = +1 Query: 73 GSPCTHI----FTYEELDAATDGFGAANE---------LGAGGFGTVYKGVLRDGS---- 201 GSP I FTYE+ + A F + +GAG FG VYKG L+ Sbjct: 587 GSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREI 646 Query: 202 VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLA 378 VA+K L S K F +E I+ + HPN++ L G + R ++++ EF+ NG L Sbjct: 647 YVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD 706 Query: 379 DHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKV 558 L N G + L +G+ AA + YL +HRD+ NIL++ L KV Sbjct: 707 SFLRQ-NDGQFTVIQL-----VGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKV 760 Query: 559 ADFGLSRLFPAD 594 +DFGLSR D Sbjct: 761 SDFGLSRYLQDD 772
>ERBB2_CANFA (O18735) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) Length = 1259 Score = 82.0 bits (201), Expect = 1e-15 Identities = 58/163 (35%), Positives = 89/163 (54%), Gaps = 9/163 (5%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGS----VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + DG VA+K L +N S K ++ +E +++ + P + L Sbjct: 725 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRL 784 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHL--HHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 G C +S + LV + +P G L DH+ H G G D +L+W V+ A ++Y Sbjct: 785 LGICLTST--VQLVTQLMPYGCLLDHVREHRGRLGSQD--LLNW------CVQIAKGMSY 834 Query: 481 LHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 L +++HRD+ N+L+ HVK+ DFGL+RL D H Sbjct: 835 LEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYH 877
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 81.6 bits (200), Expect = 2e-15 Identities = 50/163 (30%), Positives = 84/163 (51%), Gaps = 4/163 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKG---VEQFANEVDILSRLRHPNLVALYG 315 LG G +G V + R G VVA+K + K+ K + E++I+S L HP+++++Y Sbjct: 62 LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYE 121 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 + ++++ E+ G L D++ + LS + +A+ Y H + Sbjct: 122 VFENKDKIVIIMEYASKGELYDYI-------SERRRLSERETRHFFRQIVSAVHYCHKNG 174 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVSTAP 624 V+HRD+K NILLD ++K+ADFGLS L+ D Q +P Sbjct: 175 VVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSP 217
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 81.6 bits (200), Expect = 2e-15 Identities = 53/157 (33%), Positives = 86/157 (54%), Gaps = 7/157 (4%) Frame = +1 Query: 145 ELGAGGFGTVYK---GVLRD--GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVAL 309 +LG G FG+V L+D G VVAVK+L ++ + + F E++IL L+H N+V Sbjct: 854 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKY 913 Query: 310 YGCTSSC--RDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 G S R+L L+ E++P G+L D+L +L + +++ +E YL Sbjct: 914 KGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGME------YL 967 Query: 484 HAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 + +HRD+ T NIL++ VK+ DFGL+++ P D Sbjct: 968 GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD 1004 Score = 50.4 bits (119), Expect = 4e-06 Identities = 48/176 (27%), Positives = 80/176 (45%), Gaps = 17/176 (9%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD--------GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLV 303 LG G F ++KGV R+ + V +K L K E F ++S+L H +LV Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLV 610 Query: 304 ALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 YG + +LV EFV G+L +L + + + W +L +A + A A+ +L Sbjct: 611 LNYGVCVCGDENILVQEFVKFGSLDTYLKKNK----NCINILW--KLEVAKQLAWAMHFL 664 Query: 484 HAHQVLHRDVKTTNILL--------DGGLHVKVADFGLS-RLFPADGATQHVSTAP 624 + ++H +V NILL +K++D G+S + P D + + P Sbjct: 665 EENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP 720
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 81.6 bits (200), Expect = 2e-15 Identities = 57/166 (34%), Positives = 81/166 (48%), Gaps = 4/166 (2%) Frame = +1 Query: 118 ATDGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRL 285 A + F LG G FG VY + ++A+K L+K + GVE Q EV+I S L Sbjct: 129 ALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL 188 Query: 286 RHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETA 465 RHPN++ LYG + L+ E+ P GT+ L + E A Sbjct: 189 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK-------FDEQRTATYITELA 241 Query: 466 AALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGAT 603 AL+Y H+ +V+HRD+K N+LL +K+ADFG S P+ T Sbjct: 242 NALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRT 287
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 81.6 bits (200), Expect = 2e-15 Identities = 65/192 (33%), Positives = 91/192 (47%), Gaps = 5/192 (2%) Frame = +1 Query: 43 TSLRK-EFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGV-LRDGSVVAVK 216 +SLRK E +AG P + + E F LG G FG VY + G +VA+K Sbjct: 61 SSLRKIEEPIAGVPSSAGPQWREFHIGM--FEIGKPLGKGKFGRVYLAKEKKTGFIVALK 118 Query: 217 RLYKNSY---KGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHL 387 L+K+ K +Q E++I S LRH N++ LYG + + L+ EF G L HL Sbjct: 119 TLHKSELVQSKIEKQVRREIEIQSNLRHKNILRLYGHFHDEKRIYLILEFAGRGELYQHL 178 Query: 388 HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADF 567 S + A AL+YLH V+HRD+K NILL +K++DF Sbjct: 179 RRAKR-------FSEEVASKYIFQMANALSYLHKKHVIHRDIKPENILLGIDGEIKLSDF 231 Query: 568 GLSRLFPADGAT 603 G S P++ T Sbjct: 232 GWSVHAPSNRRT 243
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 81.3 bits (199), Expect = 2e-15 Identities = 50/174 (28%), Positives = 83/174 (47%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + +LG+G FG V+ G ++ VA+K L K E F E +++ Sbjct: 231 DEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTL-KEGTMSPEAFLGEANMMKA 289 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+H LV LY + + +V E++ G L D L LS P + ++ + Sbjct: 290 LQHERLVRLYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGS-----RLSLPRLIDMSAQI 343 Query: 463 AAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVSTAP 624 A +AY+ +HRD++ NIL+ L K+ADFGL+R+ ++ Q + P Sbjct: 344 AEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFP 397
>CDK2_XENLA (P23437) Cell division protein kinase 2 (EC 2.7.11.22) (CDC2| homolog Eg1 protein kinase) Length = 297 Score = 81.3 bits (199), Expect = 2e-15 Identities = 53/157 (33%), Positives = 84/157 (53%), Gaps = 3/157 (1%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHP 294 + F ++G G +G VYK R+ G +VA+K++ ++ +GV A E+ +L L HP Sbjct: 2 ENFQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L + L LV+EF+ N L + N G +S + L Sbjct: 62 NIVKLLDVIHTENKLYLVFEFL-NQDLKKFMDGSNISG-----ISLALVKSYLFQLLQGL 115 Query: 475 AYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 A+ H+H+VLHRD+K N+L++ +K+ADFGL+R F Sbjct: 116 AFCHSHRVLHRDLKPQNLLINSDGAIKLADFGLARAF 152
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 81.3 bits (199), Expect = 2e-15 Identities = 56/168 (33%), Positives = 82/168 (48%) Frame = +1 Query: 79 PCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFA 258 P T + + + D +LG G FG V+ G + VA+K L K E F Sbjct: 248 PQTQGLSRDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFL 306 Query: 259 NEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPT 438 E ++ +LRH LV LY S + +V E++ G+L D L G G L P Sbjct: 307 QEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYISKGSLLDFLK-GEMGR----YLRLPQ 360 Query: 439 RLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 + +A + A+ +AY+ +HRD++ NIL+ L KVADFGL+RL Sbjct: 361 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 408
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 81.3 bits (199), Expect = 2e-15 Identities = 56/164 (34%), Positives = 80/164 (48%), Gaps = 4/164 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRLRH 291 + F LG G FG VY R+ ++A+K L+K+ + GVE Q EV+I S LRH Sbjct: 138 EDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRH 197 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LYG + L+ ++ P G L L L + A A Sbjct: 198 PNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSAL-------YIKQLAEA 250 Query: 472 LAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGAT 603 L Y H+ +V+HRD+K N+LL +K+ADFG S P+ T Sbjct: 251 LLYCHSKKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRT 294
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 80.9 bits (198), Expect = 3e-15 Identities = 55/169 (32%), Positives = 78/169 (46%), Gaps = 4/169 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYKGVE---QFANEVDILSRLRH 291 + F LG G FG VY R ++A+K L+K + Q EV+I S LRH Sbjct: 122 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRH 181 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LYG + L+ E+ P GT+ L + E A A Sbjct: 182 PNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK-------FDEQRTATYITELANA 234 Query: 472 LAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 L+Y H+ +V+HRD+K N+LL +K+ADFG S P+ T T Sbjct: 235 LSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGT 283
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 80.9 bits (198), Expect = 3e-15 Identities = 56/157 (35%), Positives = 78/157 (49%), Gaps = 4/157 (2%) Frame = +1 Query: 130 FGAANELGAGGFGTVY-KGVLRDGSVVAVKRLYKNS---YKGVEQFANEVDILSRLRHPN 297 F LG G FG VY + G V A+K + K Y +QF EV+I S LRHPN Sbjct: 109 FEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQFRREVEIQSSLRHPN 168 Query: 298 LVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALA 477 L LYG + + L+ E++ NG L HL G + D + + + A AL Sbjct: 169 LTQLYGYFHDEKRVYLLMEYLVNGELYKHL-KGRSHFNDVVASYY------VYQMADALD 221 Query: 478 YLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFP 588 Y+H +LHRD+K NI++ +K+ DFG S + P Sbjct: 222 YMHERNILHRDIKPENIIIGFNNTIKLTDFGWSVITP 258
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 80.5 bits (197), Expect = 4e-15 Identities = 56/168 (33%), Positives = 82/168 (48%) Frame = +1 Query: 79 PCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFA 258 P T + + + D +LG G FG V+ G + VA+K L K E F Sbjct: 248 PQTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFL 306 Query: 259 NEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPT 438 E ++ +LRH LV LY S + +V E++ G+L D L G G L P Sbjct: 307 QEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLK-GEMGR----YLRLPQ 360 Query: 439 RLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 + +A + A+ +AY+ +HRD++ NIL+ L KVADFGL+RL Sbjct: 361 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 408
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 80.5 bits (197), Expect = 4e-15 Identities = 57/190 (30%), Positives = 90/190 (47%), Gaps = 2/190 (1%) Frame = +1 Query: 40 LTSLRKEFNLAG--SPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAV 213 +T LR ++ G +P T F+YE+ + ELG+G FG V G R VA+ Sbjct: 338 VTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAI 397 Query: 214 KRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHH 393 K + + + E F E ++ +L HP LV LYG + + + +V EF+ G L + L Sbjct: 398 KAIREGAMCE-EDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ 456 Query: 394 GNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGL 573 ++LS + + + YL + +HRD+ N L+ VKV+DFG+ Sbjct: 457 RQGHFSRDVLLS------MCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGM 510 Query: 574 SRLFPADGAT 603 +R F D T Sbjct: 511 ARYFLDDQYT 520
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 80.5 bits (197), Expect = 4e-15 Identities = 56/164 (34%), Positives = 80/164 (48%), Gaps = 4/164 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRLRH 291 + F LG G FG VY + ++A+K L+K + GVE Q EV+I S LRH Sbjct: 124 EDFDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKVQLEKAGVEHQLRREVEIQSHLRH 183 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LYG + L+ E+ P GT+ L + E A A Sbjct: 184 PNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK-------FDEQRTATYITELANA 236 Query: 472 LAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGAT 603 L+Y H+ +V+HRD+K N+LL +K+ADFG S P+ T Sbjct: 237 LSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRT 280
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 80.5 bits (197), Expect = 4e-15 Identities = 53/146 (36%), Positives = 76/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E ++ +LRH LV LY S Sbjct: 271 KLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHKKLVQLYAVVS 329 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G G L P + +A + A+ +AY+ +H Sbjct: 330 E-EPIYIVIEYMSKGSLLDFLK-GEMGK----YLRLPQLVDMAAQIASGMAYVERMNYVH 383 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 384 RDLRAANILVGENLVCKVADFGLARL 409
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 80.5 bits (197), Expect = 4e-15 Identities = 53/146 (36%), Positives = 76/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E ++ +LRH LV LY S Sbjct: 271 KLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 329 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G G L P + +A + A+ +AY+ +H Sbjct: 330 E-EPIYIVIEYMSKGSLLDFLK-GEMGK----YLRLPQLVDMAAQIASGMAYVERMNYVH 383 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 384 RDLRAANILVGENLVCKVADFGLARL 409
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 80.5 bits (197), Expect = 4e-15 Identities = 55/164 (33%), Positives = 80/164 (48%), Gaps = 4/164 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRLRH 291 + F LG G FG VY R+ ++A+K L+K+ + GVE Q EV+I S LRH Sbjct: 138 EDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRH 197 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LYG + L+ ++ P G L L + + A A Sbjct: 198 PNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSAM-------YIKQLAEA 250 Query: 472 LAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGAT 603 L Y H+ +V+HRD+K N+LL +K+ADFG S P+ T Sbjct: 251 LLYCHSKKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRT 294
>ROR2_HUMAN (Q01974) Tyrosine-protein kinase transmembrane receptor ROR2| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) Length = 943 Score = 80.5 bits (197), Expect = 4e-15 Identities = 56/168 (33%), Positives = 89/168 (52%), Gaps = 18/168 (10%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGV--EQFANEVDILSRLRHPNL 300 ELG FG VYKG L VA+K L K+ +G E+F +E + +RL+HPN+ Sbjct: 478 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTL-KDKAEGPLREEFRHEAMLRARLQHPNV 536 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHL----HHGNAGGGDP-----LMLSWPTRLGIA 453 V L G + + L +++ + +G L + L H + G D L P + + Sbjct: 537 VCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLV 596 Query: 454 VETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR-LFPAD 594 + AA + YL +H V+H+D+ T N+L+ L+VK++D GL R ++ AD Sbjct: 597 AQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAAD 644
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 80.5 bits (197), Expect = 4e-15 Identities = 52/146 (35%), Positives = 75/146 (51%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E ++ +LRH LV LY S Sbjct: 274 KLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 332 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G L P + +A + A+ +AY+ +H Sbjct: 333 E-EPIYIVTEYMSKGSLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 386 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 387 RDLRAANILVGENLVCKVADFGLARL 412
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 80.1 bits (196), Expect = 5e-15 Identities = 53/146 (36%), Positives = 76/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E ++ +LRH LV LY S Sbjct: 271 KLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 329 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G G L P + +A + A+ +AY+ +H Sbjct: 330 E-EPIYIVTEYMSKGSLLDFLK-GEMGK----YLRLPQLVDMAAQIASGMAYVERMNYVH 383 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 384 RDLRAANILVGENLVCKVADFGLARL 409
>SN1L2_MOUSE (Q8CFH6) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Salt-inducible kinase 2) Length = 931 Score = 80.1 bits (196), Expect = 5e-15 Identities = 50/150 (33%), Positives = 75/150 (50%), Gaps = 4/150 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSV-VAVKRLYKNSYKGV--EQFANEVDILSRLRHPNLVALYGC 318 LG G F V G R VA+K + K+ V E+ EV I+ L HP+++ LY Sbjct: 26 LGKGNFAVVKLGRHRTTKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQV 85 Query: 319 TSSCRDLLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 + L LV E+ NG + D+L +HG + W + +A+ Y H + Sbjct: 86 METKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFW--------QILSAVDYCHGRK 137 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 V+HRD+K N+LLD +++K+ADFG F Sbjct: 138 VVHRDLKAENLLLDNNMNIKIADFGFGNFF 167
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 80.1 bits (196), Expect = 5e-15 Identities = 53/146 (36%), Positives = 76/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E ++ +LRH LV LY S Sbjct: 271 KLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 329 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G G L P + +A + A+ +AY+ +H Sbjct: 330 E-EPIYIVTEYMSKGSLLDFLK-GEMGK----YLRLPQLVDMAAQIASGMAYVERMNYVH 383 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 384 RDLRAANILVGENLVCKVADFGLARL 409
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 80.1 bits (196), Expect = 5e-15 Identities = 49/160 (30%), Positives = 82/160 (51%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + + LGAG FG V+ G + + VAVK L + S + F E +++ + Sbjct: 235 DEWEVPRETLKLVERLGAGQFGEVWMGYYNEHTKVAVKSLKQGSMSP-DAFLAEANLMKQ 293 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+H LV LY + + ++ E++ NG+L D L + + L+ L +A + Sbjct: 294 LQHKRLVRLYAVVTE-EPIYIITEYMENGSLVDFLKTPSG-----IKLTINKLLDMAAQI 347 Query: 463 AAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 +A+L +HRD++ NIL+ L K+ADFGL+RL Sbjct: 348 VEGMAFLEERNYIHRDLRAANILVSDTLSCKIADFGLARL 387
>CDC2H_DICDI (P34117) CDC2-like serine/threonine-protein kinase CRP (EC| 2.7.11.22) (EC 2.7.11.23) Length = 292 Score = 80.1 bits (196), Expect = 5e-15 Identities = 54/155 (34%), Positives = 87/155 (56%), Gaps = 3/155 (1%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHPNL 300 + +LG G +G V K R+ G +VA+KR+ +S +GV A E+ +L L+HPN+ Sbjct: 4 YSKIEKLGEGTYGIVNKAKNRETGEIVALKRIRLDSEDEGVPCTAIREISLLKELKHPNI 63 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 V L+ + R L LV+E++ D + + GG+ +S PT + +A+ Sbjct: 64 VRLHDVIHTERKLTLVFEYLDQ----DLKKYLDECGGE---ISKPTIKSFMYQLLKGVAF 116 Query: 481 LHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 H H+VLHRD+K N+L++ +K+ADFGL+R F Sbjct: 117 CHDHRVLHRDLKPQNLLINRKGELKLADFGLARAF 151
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 80.1 bits (196), Expect = 5e-15 Identities = 53/146 (36%), Positives = 76/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E ++ +LRH LV LY S Sbjct: 271 KLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 329 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G G L P + +A + A+ +AY+ +H Sbjct: 330 E-EPIYIVTEYMSKGSLLDFLK-GEMGK----YLRLPQLVDMAAQIASGMAYVERMNYVH 383 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 384 RDLRAANILVGENLVCKVADFGLARL 409
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 80.1 bits (196), Expect = 5e-15 Identities = 53/146 (36%), Positives = 76/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E ++ +LRH LV LY S Sbjct: 271 KLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 329 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G G L P + +A + A+ +AY+ +H Sbjct: 330 E-EPIYIVTEYMSKGSLLDFLK-GEMGK----YLRLPQLVDMAAQIASGMAYVERMNYVH 383 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 384 RDLRAANILVGENLVCKVADFGLARL 409
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 80.1 bits (196), Expect = 5e-15 Identities = 53/146 (36%), Positives = 76/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E ++ +LRH LV LY S Sbjct: 271 KLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 329 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G G L P + +A + A+ +AY+ +H Sbjct: 330 E-EPIYIVTEYMSKGSLLDFLK-GEMGK----YLRLPQLVDMAAQIASGMAYVERMNYVH 383 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 384 RDLRAANILVGENLVCKVADFGLARL 409
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 80.1 bits (196), Expect = 5e-15 Identities = 53/146 (36%), Positives = 76/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E ++ +LRH LV LY S Sbjct: 271 KLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVRLYAVVS 329 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G G L P + +A + A+ +AY+ +H Sbjct: 330 E-EPIYIVTEYMSKGSLLDFLK-GEMGK----YLRLPQLVDMAAQIASGMAYVERMNYVH 383 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 384 RDLRAANILVGENLVCKVADFGLARL 409
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 80.1 bits (196), Expect = 5e-15 Identities = 52/157 (33%), Positives = 82/157 (52%), Gaps = 4/157 (2%) Frame = +1 Query: 163 FGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCR-DL 339 +GTVYK L DG +A++ L + + K + L R+RH NLV L R + Sbjct: 384 YGTVYKAKLSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRAFYQGKRGEK 443 Query: 340 LLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ---VLHRD 510 LL+Y+++PN +L D LH L+W R IA+ A LAYLH Q ++H + Sbjct: 444 LLIYDYLPNISLHDLLHESKP---RKPALNWARRHKIALGIARGLAYLHTGQEVPIIHGN 500 Query: 511 VKTTNILLDGGLHVKVADFGLSRLFPADGATQHVSTA 621 +++ N+L+D ++ +FGL ++ A + VS A Sbjct: 501 IRSKNVLVDDFFFARLTEFGLDKIMVQAVADEIVSQA 537
>ERBB2_HUMAN (P04626) Receptor tyrosine-protein kinase erbB-2 precursor (EC| 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19) Length = 1255 Score = 80.1 bits (196), Expect = 5e-15 Identities = 54/161 (33%), Positives = 86/161 (53%), Gaps = 7/161 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGS----VVAVKRLYKN-SYKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + DG VA+K L +N S K ++ +E +++ + P + L Sbjct: 726 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRL 785 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 G C +S + LV + +P G L DH+ G +L+W ++ A ++YL Sbjct: 786 LGICLTST--VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW------CMQIAKGMSYLE 837 Query: 487 AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 +++HRD+ N+L+ HVK+ DFGL+RL D H Sbjct: 838 DVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYH 878
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 80.1 bits (196), Expect = 5e-15 Identities = 53/146 (36%), Positives = 76/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E ++ +LRH LV LY S Sbjct: 268 KLGQGYFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAMVS 326 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G G L P + +A + A+ +AY+ +H Sbjct: 327 E-EPIYIVIEYMSKGSLLDFLK-GEMGK----YLRLPQLVEMAAQIASGMAYVERMNYVH 380 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 381 RDLRAANILVGENLVCKVADFGLARL 406
>PHO85_DEBHA (Q6BRY2) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 330 Score = 79.7 bits (195), Expect = 6e-15 Identities = 50/161 (31%), Positives = 82/161 (50%), Gaps = 2/161 (1%) Frame = +1 Query: 109 LDAATDGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFA-NEVDILSR 282 + ++ F +LG G + TVYKG R +G +VA+K + +S +G A E+ ++ Sbjct: 1 MTGSSSQFQQLEKLGEGTYATVYKGRNRTNGQLVALKEINLDSEEGTPSTAIREISLMKE 60 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L H N+V LY + L LV+EF+ HGN G D ++ + Sbjct: 61 LDHENIVTLYDVIHTENKLTLVFEFMDKDLKKYMEAHGNQGALDLKIVK-----SFIFQL 115 Query: 463 AAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 + + H ++VLHRD+K N+L++ +K+ DFGL+R F Sbjct: 116 LKGIMFCHDNRVLHRDLKPQNLLINNKGELKLGDFGLARAF 156
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 79.7 bits (195), Expect = 6e-15 Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 1/153 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +G G +G VYK + + VVA+K + + + + E+ +L L H N+V +G Sbjct: 31 IGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIR 90 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 +L ++ E+ NG+L + + G + ++ T +T L YLH V+H Sbjct: 91 KSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVT------QTLLGLKYLHGEGVIH 144 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRLFPADGAT 603 RD+K NILL VK+ADFG+S + + T Sbjct: 145 RDIKAANILLSADNTVKLADFGVSTIVNSSALT 177
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 79.7 bits (195), Expect = 6e-15 Identities = 49/160 (30%), Positives = 82/160 (51%) Frame = +1 Query: 103 EELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSR 282 +E + + LGAG FG V+ G + VAVK L + S + F E +++ + Sbjct: 235 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSP-DAFLAEANLMKQ 293 Query: 283 LRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVET 462 L+H LV LY + + ++ E++ NG+L D L + + L+ L +A + Sbjct: 294 LQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSG-----IKLTINKLLDMAAQI 347 Query: 463 AAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 A +A++ +HRD++ NIL+ L K+ADFGL+RL Sbjct: 348 AEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARL 387
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 79.7 bits (195), Expect = 6e-15 Identities = 49/154 (31%), Positives = 80/154 (51%), Gaps = 2/154 (1%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFA-NEVDILSRLRHPNLV 303 F +LG G + TVYKG R G +VA+K + +S +G A E+ ++ L+H N+V Sbjct: 7 FQQLEKLGEGTYATVYKGRNRTTGQLVALKEINLDSEEGTPSTAIREISLMKELKHENIV 66 Query: 304 ALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYL 483 LY + L LV+E++ +GN G + + W + + + Sbjct: 67 TLYDVIHTENKLNLVFEYMDKDLKKFMDTNGNKGALETKQVKW-----FMYQLLRGILFC 121 Query: 484 HAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 H ++VLHRD+K N+L++ +K+ADFGL+R F Sbjct: 122 HDNRVLHRDLKPQNLLINAKGQLKLADFGLARAF 155
>CDC2H_PLACH (Q4Y4B1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 79.7 bits (195), Expect = 6e-15 Identities = 56/164 (34%), Positives = 83/164 (50%), Gaps = 6/164 (3%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRL-YKNSYKGVEQFA-NEVDILSRLRHPNLVALYGC 318 ++G G +G VYK DG A+K++ + +G+ A E+ IL LRH N+V LY Sbjct: 9 KIGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTAIREISILKELRHSNIVKLYDV 68 Query: 319 TSSCRDLLLVYEFVPNGT--LADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAH 492 + + L+LV+E + L D G L T ++ +AY H H Sbjct: 69 IHAKKRLILVFEHLDQDLKKLIDVCDGG---------LESVTAKSFLLQLLNGIAYCHEH 119 Query: 493 QVLHRDVKTTNILLDGGLHVKVADFGLSRLF--PADGATQHVST 618 +VLHRD+K N+L++ +K+ADFGL+R F PA T V T Sbjct: 120 RVLHRDLKPQNLLINREGELKIADFGLARAFGIPARRYTHEVVT 163
>CDC2H_PLABA (Q4Z6R1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 79.7 bits (195), Expect = 6e-15 Identities = 56/164 (34%), Positives = 83/164 (50%), Gaps = 6/164 (3%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRL-YKNSYKGVEQFA-NEVDILSRLRHPNLVALYGC 318 ++G G +G VYK DG A+K++ + +G+ A E+ IL LRH N+V LY Sbjct: 9 KIGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTAIREISILKELRHSNIVKLYDV 68 Query: 319 TSSCRDLLLVYEFVPNGT--LADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAH 492 + + L+LV+E + L D G L T ++ +AY H H Sbjct: 69 IHAKKRLILVFEHLDQDLKKLIDVCDGG---------LESVTAKSFLLQLLNGIAYCHEH 119 Query: 493 QVLHRDVKTTNILLDGGLHVKVADFGLSRLF--PADGATQHVST 618 +VLHRD+K N+L++ +K+ADFGL+R F PA T V T Sbjct: 120 RVLHRDLKPQNLLINREGELKIADFGLARAFGIPARRYTHEVVT 163
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 79.7 bits (195), Expect = 6e-15 Identities = 51/153 (33%), Positives = 79/153 (51%), Gaps = 9/153 (5%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLY--------KNSYKGVEQFANEVDILSRLRHPNL 300 +G G FGTVY G+ L G ++AVK++ + + +++ EV +L L HPN+ Sbjct: 75 IGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNI 134 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 V G L ++ EFVP G+++ L G ++ TR + L Y Sbjct: 135 VRYLGTVREDDTLNILLEFVPGGSISSLLE--KFGPFPESVVRTYTR-----QLLLGLEY 187 Query: 481 LHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 LH H ++HRD+K NIL+D +K+ADFG S+ Sbjct: 188 LHNHAIMHRDIKGANILVDNKGCIKLADFGASK 220
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 79.3 bits (194), Expect = 8e-15 Identities = 51/147 (34%), Positives = 79/147 (53%), Gaps = 3/147 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYK--NSYKGVEQFANEVDILSRLRHPNLVALYGC 318 +G G FG VYKG + VVA+K + K S K + E++I+ LRHPN+V + Sbjct: 10 IGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDS 69 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +++++V ++ G L L D + IA + +AL YLH+H++ Sbjct: 70 FETDKEVVVVTDYA-EGELLQILEDDGKLPEDQVQ-------AIAAQLVSALYYLHSHRI 121 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSR 579 LHRD+K NILL G +K+ DFG +R Sbjct: 122 LHRDMKPQNILLAKGGGIKLCDFGFAR 148
>SN1L2_HUMAN (Q9H0K1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 926 Score = 79.3 bits (194), Expect = 8e-15 Identities = 49/150 (32%), Positives = 76/150 (50%), Gaps = 4/150 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGV--EQFANEVDILSRLRHPNLVALYGC 318 LG G F V G R + VA+K + K+ V E+ EV I+ L HP+++ LY Sbjct: 26 LGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQV 85 Query: 319 TSSCRDLLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 + L LV E+ NG + D+L +HG + W + +A+ Y H + Sbjct: 86 METKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFW--------QILSAVDYCHGRK 137 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 ++HRD+K N+LLD +++K+ADFG F Sbjct: 138 IVHRDLKAENLLLDNNMNIKIADFGFGNFF 167
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 79.3 bits (194), Expect = 8e-15 Identities = 53/155 (34%), Positives = 80/155 (51%), Gaps = 5/155 (3%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVE---QFANEVDILSRLRHPNLVALYG 315 LG G FG V G + G VAVK L + + ++ + E+ L RHP+++ LY Sbjct: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 Query: 316 CTSSCRDLLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAH 492 S+ D +V E+V G L D++ HG + L + +A+ Y H H Sbjct: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQ--------QILSAVDYCHRH 133 Query: 493 QVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 V+HRD+K N+LLD ++ K+ADFGLS + +DG Sbjct: 134 MVVHRDLKPENVLLDAQMNAKIADFGLSNMM-SDG 167
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 79.3 bits (194), Expect = 8e-15 Identities = 53/155 (34%), Positives = 80/155 (51%), Gaps = 5/155 (3%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVE---QFANEVDILSRLRHPNLVALYG 315 LG G FG V G + G VAVK L + + ++ + E+ L RHP+++ LY Sbjct: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 Query: 316 CTSSCRDLLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAH 492 S+ D +V E+V G L D++ HG + L + +A+ Y H H Sbjct: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ--------QILSAVDYCHRH 133 Query: 493 QVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 V+HRD+K N+LLD ++ K+ADFGLS + +DG Sbjct: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNIM-SDG 167
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 79.3 bits (194), Expect = 8e-15 Identities = 53/155 (34%), Positives = 80/155 (51%), Gaps = 5/155 (3%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVE---QFANEVDILSRLRHPNLVALYG 315 LG G FG V G + G VAVK L + + ++ + E+ L RHP+++ LY Sbjct: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 Query: 316 CTSSCRDLLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAH 492 S+ D +V E+V G L D++ HG + L + +A+ Y H H Sbjct: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ--------QILSAVDYCHRH 133 Query: 493 QVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 V+HRD+K N+LLD ++ K+ADFGLS + +DG Sbjct: 134 MVVHRDLKPENVLLDAQMNAKIADFGLSNMM-SDG 167
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 79.3 bits (194), Expect = 8e-15 Identities = 53/155 (34%), Positives = 80/155 (51%), Gaps = 5/155 (3%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVE---QFANEVDILSRLRHPNLVALYG 315 LG G FG V G + G VAVK L + + ++ + E+ L RHP+++ LY Sbjct: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 Query: 316 CTSSCRDLLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAH 492 S+ D +V E+V G L D++ HG + L + +A+ Y H H Sbjct: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ--------QILSAVDYCHRH 133 Query: 493 QVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 V+HRD+K N+LLD ++ K+ADFGLS + +DG Sbjct: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMM-SDG 167
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 79.3 bits (194), Expect = 8e-15 Identities = 50/145 (34%), Positives = 74/145 (51%), Gaps = 1/145 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVE-QFANEVDILSRLRHPNLVALYGCTS 324 LG G FG VYKG L+D + VAVK ++ + ++ +F E IL + HPN+V L G + Sbjct: 70 LGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCT 129 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + + ++ E VP G L D L L R + V AA + YL +H Sbjct: 130 QRQPVYIIMELVPGGDFLSFLRKRK----DELKLKQLVRFSLDV--AAGMLYLEGKNCIH 183 Query: 505 RDVKTTNILLDGGLHVKVADFGLSR 579 RD+ N L+ +K++DFG+SR Sbjct: 184 RDLAARNCLVGENNTLKISDFGMSR 208
>EGFR_DROME (P04412) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Egfr) (Gurken receptor) (Protein torpedo) (Drosophila relative of ERBB) Length = 1426 Score = 79.3 bits (194), Expect = 8e-15 Identities = 52/156 (33%), Positives = 86/156 (55%), Gaps = 7/156 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGS----VVAVKRLYKNS-YKGVEQFANEVDILSRLRHPNLVAL 309 LG G FG VYKGV + +G VA+K L K++ + E+F E I++ H NL+ L Sbjct: 944 LGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKL 1003 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 C SS ++L+ + +P G L D++ + G +L+W T++ A ++YL Sbjct: 1004 LAVCMSS--QMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQI------AKGMSYLE 1055 Query: 487 AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 +++HRD+ N+L+ VK+ DFGL++L +D Sbjct: 1056 EKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSD 1091
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 79.3 bits (194), Expect = 8e-15 Identities = 66/182 (36%), Positives = 94/182 (51%), Gaps = 23/182 (12%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYK---GVEQFANEVDILSRLRHPNLVALYG- 315 +G G FG V +G R+ V A+K +Y++ +K + F NEV ILS+LRHPN+V G Sbjct: 1295 IGKGFFGEVKRGYWRETDV-AIKIIYRDQFKTKSSLVMFQNEVGILSKLRHPNVVQFLGA 1353 Query: 316 CTSSCRD-LLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH- 486 CT+ D +V E++ G+L L H N +P + RL +A++ A + YLH Sbjct: 1354 CTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPHI-----RLKLALDIAKGMNYLHG 1408 Query: 487 -AHQVLHRDVKTTNILLDGG-------------LHVKVADFGLSRL--FPADGATQHVST 618 +LHRD+ + NILLD + K++DFGLSRL A TQ V Sbjct: 1409 WTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKKEQASQMTQSVGC 1468 Query: 619 AP 624 P Sbjct: 1469 IP 1470
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 79.0 bits (193), Expect = 1e-14 Identities = 47/143 (32%), Positives = 75/143 (52%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVYKG V + + + + ++ F NEV +L + RH N++ G ++ Sbjct: 463 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK 522 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + L +V ++ +L HLH + IA +TA + YLHA ++HR Sbjct: 523 PQ-LAIVTQWCEGSSLYHHLHIIET------KFEMIKLIDIARQTAQGMDYLHAKSIIHR 575 Query: 508 DVKTTNILLDGGLHVKVADFGLS 576 D+K+ NI L L VK+ DFGL+ Sbjct: 576 DLKSNNIFLHEDLTVKIGDFGLA 598
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 79.0 bits (193), Expect = 1e-14 Identities = 51/146 (34%), Positives = 75/146 (51%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E ++ +LRH LV LY S Sbjct: 279 KLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 337 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G L P + ++ + A+ +AY+ +H Sbjct: 338 E-EPIYIVTEYMNKGSLLDFLK-----GETGKYLRLPQLVDMSAQIASGMAYVERMNYVH 391 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 392 RDLRAANILVGENLVCKVADFGLARL 417
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 79.0 bits (193), Expect = 1e-14 Identities = 47/143 (32%), Positives = 75/143 (52%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVYKG V + + + + ++ F NEV +L + RH N++ G ++ Sbjct: 25 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK 84 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + L +V ++ +L HLH + IA +TA + YLHA ++HR Sbjct: 85 PQ-LAIVTQWCEGSSLYHHLHIIET------KFEMIKLIDIARQTAQGMDYLHAKSIIHR 137 Query: 508 DVKTTNILLDGGLHVKVADFGLS 576 D+K+ NI L L VK+ DFGL+ Sbjct: 138 DLKSNNIFLHEDLTVKIGDFGLA 160
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 79.0 bits (193), Expect = 1e-14 Identities = 51/147 (34%), Positives = 79/147 (53%), Gaps = 3/147 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYK--NSYKGVEQFANEVDILSRLRHPNLVALYGC 318 +G G FG VYKG + VVA+K + K S K + E++I+ LRHPN+V + Sbjct: 10 IGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDS 69 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + +++++V ++ G L L D + IA + +AL YLH+H++ Sbjct: 70 FETDKEVVVVTDYA-EGELFQILEDDGKLPEDQVQ-------AIAAQLVSALYYLHSHRI 121 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSR 579 LHRD+K NILL G +K+ DFG +R Sbjct: 122 LHRDMKPQNILLAKGGGIKLCDFGFAR 148
>CC2H3_TRYBB (P54666) Cell division control protein 2 homolog 3 (EC 2.7.11.22)| Length = 311 Score = 79.0 bits (193), Expect = 1e-14 Identities = 53/157 (33%), Positives = 81/157 (51%), Gaps = 3/157 (1%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRL-YKNSYKGVEQFA-NEVDILSRLRHP 294 D + + LG G +G VY+ V R G +VA+K++ + +G+ Q A EV IL + HP Sbjct: 21 DRYNRMDILGEGTYGVVYRAVDRATGQIVALKKVRLDRTDEGIPQTALREVSILQEIHHP 80 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L + L L++E+V + G A G L I + L Sbjct: 81 NIVNLLDVICADGKLYLIFEYVDHDLKKALEKRGGAFTGTTLKK-------IIYQLLEGL 133 Query: 475 AYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 ++ H H+++HRD+K NIL+ VK+ADFGL+R F Sbjct: 134 SFCHRHRIVHRDLKPANILVTTDNSVKIADFGLARAF 170
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 79.0 bits (193), Expect = 1e-14 Identities = 47/143 (32%), Positives = 75/143 (52%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVYKG V + + + + ++ F NEV +L + RH N++ G ++ Sbjct: 503 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK 562 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + L +V ++ +L HLH + IA +TA + YLHA ++HR Sbjct: 563 PQ-LAIVTQWCEGSSLYHHLHIIET------KFEMIKLIDIARQTAQGMDYLHAKSIIHR 615 Query: 508 DVKTTNILLDGGLHVKVADFGLS 576 D+K+ NI L L VK+ DFGL+ Sbjct: 616 DLKSNNIFLHEDLTVKIGDFGLA 638
>CDK3_MOUSE (Q80YP0) Truncated cell division protein kinase 3 homolog| Length = 186 Score = 79.0 bits (193), Expect = 1e-14 Identities = 51/157 (32%), Positives = 84/157 (53%), Gaps = 3/157 (1%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLYKN-SYKGVEQFA-NEVDILSRLRHP 294 D F ++G G +G VYK + G +VA+K++ + +GV A E+ +L L+HP Sbjct: 2 DVFQKVEKIGEGTYGVVYKARNKVTGQLVALKKIRLDLEAEGVPSTAVREISLLKELKHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N++ L + L +V+EF+ D H ++ L L P + + Sbjct: 62 NIIKLLDVVHREKKLYMVFEFLTQ----DLKRHMDSSPTSELPL--PVVKSYLAQLLEGV 115 Query: 475 AYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 ++ H+H+V+HRD+K N+LLDG +K+ADFGL+R F Sbjct: 116 SFCHSHRVIHRDLKPQNLLLDGLGAIKLADFGLARAF 152
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 79.0 bits (193), Expect = 1e-14 Identities = 54/146 (36%), Positives = 82/146 (56%), Gaps = 4/146 (2%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 ++G G +G V K V RD +VAVK + ++ + + EV LSR++HPN++AL+G +S Sbjct: 24 KVGHGSYGVVCKAVWRD-KLVAVKEFFASAEQ--KDIEKEVKQLSRVKHPNIIALHGISS 80 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA---HQ 495 + L+ EF G+L + LH G S + A + A LAYLHA Sbjct: 81 YQQATYLIMEFAEGGSLHNFLH-----GKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKP 135 Query: 496 VLHRDVKTTNILL-DGGLHVKVADFG 570 ++HRDVK N+LL + G ++K+ DFG Sbjct: 136 LIHRDVKPLNLLLTNKGRNLKICDFG 161
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 79.0 bits (193), Expect = 1e-14 Identities = 47/143 (32%), Positives = 75/143 (52%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVYKG V + + + + ++ F NEV +L + RH N++ G ++ Sbjct: 503 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK 562 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + L +V ++ +L HLH + IA +TA + YLHA ++HR Sbjct: 563 PQ-LAIVTQWCEGSSLYHHLHIIET------KFEMIKLIDIARQTAQGMDYLHAKSIIHR 615 Query: 508 DVKTTNILLDGGLHVKVADFGLS 576 D+K+ NI L L VK+ DFGL+ Sbjct: 616 DLKSNNIFLHEDLTVKIGDFGLA 638
>ERBB_ALV (P00534) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 634 Score = 79.0 bits (193), Expect = 1e-14 Identities = 52/167 (31%), Positives = 88/167 (52%), Gaps = 7/167 (4%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGV-LRDGSVV----AVKRLYK-NSYKGVEQFANEVDILSRLRH 291 F LG+G FGTVYKG+ + +G V A+K L + S K ++ +E +++ + + Sbjct: 132 FKKVKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 191 Query: 292 PNLVALYG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAA 468 P++ L G C +S + L+ + +P G L D++ G +L+W V+ A Sbjct: 192 PHVCRLLGICLTST--VQLITQLMPYGCLLDYIREHKDNIGSQYLLNW------CVQIAK 243 Query: 469 ALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 + YL +++HRD+ N+L+ HVK+ DFGL++L AD H Sbjct: 244 GMNYLEERRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGADEKEYH 290
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 79.0 bits (193), Expect = 1e-14 Identities = 47/143 (32%), Positives = 75/143 (52%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVYKG V + + + + ++ F NEV +L + RH N++ G ++ Sbjct: 89 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK 148 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + L +V ++ +L HLH + IA +TA + YLHA ++HR Sbjct: 149 PQ-LAIVTQWCEGSSLYHHLHIIET------KFEMIKLIDIARQTAQGMDYLHAKSIIHR 201 Query: 508 DVKTTNILLDGGLHVKVADFGLS 576 D+K+ NI L L VK+ DFGL+ Sbjct: 202 DLKSNNIFLHEDLTVKIGDFGLA 224
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 79.0 bits (193), Expect = 1e-14 Identities = 47/143 (32%), Positives = 75/143 (52%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVYKG V + + + + ++ F NEV +L + RH N++ G ++ Sbjct: 73 IGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTK 132 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + L +V ++ +L HLH + IA +TA + YLHA ++HR Sbjct: 133 PQ-LAIVTQWCEGSSLYHHLHIIET------KFEMIKLIDIARQTAQGMDYLHAKSIIHR 185 Query: 508 DVKTTNILLDGGLHVKVADFGLS 576 D+K+ NI L L VK+ DFGL+ Sbjct: 186 DLKSNNIFLHEDLTVKIGDFGLA 208
>CDKL1_RAT (Q66HE7) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 79.0 bits (193), Expect = 1e-14 Identities = 56/163 (34%), Positives = 86/163 (52%), Gaps = 5/163 (3%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQ--FANEVDILSRLRHPNLVALYG 315 ++G G +G V+K RD G +VA+KR + V + E+ +L +L+HPNLV+L Sbjct: 9 KIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNLVSLLE 68 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 R L LV+E+ + T+ L G +PL+ + I +T A+ + H H Sbjct: 69 VFRRKRRLHLVFEYCHH-TVLHELDRYQRGVPEPLVKN------ITWQTLQAVNFCHKHN 121 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLF--PADGATQHVST 618 +HRDVK NIL+ +K+ DFG +RL P D T +V+T Sbjct: 122 CIHRDVKPENILITKHSVIKLCDFGFARLLTGPGDYYTDYVAT 164
>CDC2_RANDY (Q9W739) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 302 Score = 78.6 bits (192), Expect = 1e-14 Identities = 53/157 (33%), Positives = 84/157 (53%), Gaps = 3/157 (1%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRL-YKNSYKGVEQFA-NEVDILSRLRHP 294 D + ++G G +G VYKGV + G +VA+K++ +N +GV A E+ +L L+HP Sbjct: 2 DEYAKIEKIGEGTYGVVYKGVHKATGQIVAMKKIRLENEEEGVPSTAIREISLLKELQHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L L L++EF+ + L +L +G ML + + Sbjct: 62 NIVCLLDVLMQDSRLYLIFEFL-SMDLKKYLDSIPSGQYLEAMLV----KSYLYQILQGI 116 Query: 475 AYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 + HA +VLHRD+K N+L+D +K+ADFGL+R F Sbjct: 117 IFCHARRVLHRDLKPQNLLIDSKGVIKLADFGLARAF 153
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 78.6 bits (192), Expect = 1e-14 Identities = 51/146 (34%), Positives = 75/146 (51%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LG G FG V+ G + VA+K L K E F E ++ +LRH LV LY S Sbjct: 274 KLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 332 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V E++ G+L D L G L P + ++ + A+ +AY+ +H Sbjct: 333 E-EPIYIVTEYMNKGSLLDFLK-----GETGKYLRLPQLVDMSAQIASGMAYVDRMNYVH 386 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L KVADFGL+RL Sbjct: 387 RDLRAANILVGENLVCKVADFGLARL 412
>SN1L2_CHICK (Q9IA88) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) (Qin-induced kinase) Length = 798 Score = 78.6 bits (192), Expect = 1e-14 Identities = 48/150 (32%), Positives = 76/150 (50%), Gaps = 4/150 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSY--KGVEQFANEVDILSRLRHPNLVALYGC 318 LG G F V R + VA+K + K +E+ EV I+ L HP+++ LY Sbjct: 32 LGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDPSNLEKIYREVQIMKLLNHPHIIKLYQV 91 Query: 319 TSSCRDLLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 + L +V EF NG + DHL +G+ + W + +A+ Y H+H Sbjct: 92 METKDMLYIVTEFAKNGEMFDHLTSNGHLSESEARKKFW--------QILSAVEYCHSHH 143 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 ++HRD+KT N+LLD +++K+ADFG + Sbjct: 144 IVHRDLKTENLLLDANMNIKLADFGFGNFY 173
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 78.6 bits (192), Expect = 1e-14 Identities = 45/143 (31%), Positives = 77/143 (53%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G G FGTV++G V V ++ + + + + F NE+ +L + RH N++ G + Sbjct: 316 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 375 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 ++ ++ +L HLH + D + L + +A +TA + YLHA ++HR Sbjct: 376 -PGFAIITQWCEGSSLYHHLHVADTRF-DMVQL-----IDVARQTAQGMDYLHAKNIIHR 428 Query: 508 DVKTTNILLDGGLHVKVADFGLS 576 D+K+ NI L GL VK+ DFGL+ Sbjct: 429 DLKSNNIFLHEGLTVKIGDFGLA 451
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 78.6 bits (192), Expect = 1e-14 Identities = 45/143 (31%), Positives = 77/143 (53%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G G FGTV++G V V ++ + + + + F NE+ +L + RH N++ G + Sbjct: 316 IGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 375 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 ++ ++ +L HLH + D + L + +A +TA + YLHA ++HR Sbjct: 376 -PGFAIITQWCEGSSLYHHLHVADTRF-DMVQL-----IDVARQTAQGMDYLHAKNIIHR 428 Query: 508 DVKTTNILLDGGLHVKVADFGLS 576 D+K+ NI L GL VK+ DFGL+ Sbjct: 429 DLKSNNIFLHEGLTVKIGDFGLA 451
>CDKL1_MOUSE (Q8CEQ0) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 78.6 bits (192), Expect = 1e-14 Identities = 56/163 (34%), Positives = 85/163 (52%), Gaps = 5/163 (3%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQ--FANEVDILSRLRHPNLVALYG 315 ++G G +G V+K RD G +VA+KR + V + E+ +L +L+HPNLV L Sbjct: 9 KIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNLVNLLE 68 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 R L LV+E+ + T+ L G +PL+ + I +T A+ + H H Sbjct: 69 VFRRKRRLHLVFEYCDH-TVLHELDRYQRGVPEPLVKN------ITWQTLQAVNFCHKHN 121 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLF--PADGATQHVST 618 +HRDVK NIL+ +K+ DFG +RL P D T +V+T Sbjct: 122 CIHRDVKPENILITKQSAIKLCDFGFARLLTGPGDYYTDYVAT 164
>ERBB_AVIER (P00535) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 604 Score = 78.6 bits (192), Expect = 1e-14 Identities = 51/167 (30%), Positives = 88/167 (52%), Gaps = 7/167 (4%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGV-LRDGSVV----AVKRLYK-NSYKGVEQFANEVDILSRLRH 291 F LG+G FGT+YKG+ + +G V A+K L + S K ++ +E +++ + + Sbjct: 132 FKKVKVLGSGAFGTIYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 191 Query: 292 PNLVALYG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAA 468 P++ L G C +S + L+ + +P G L D++ G +L+W V+ A Sbjct: 192 PHVCRLLGICLTST--VQLITQLMPYGCLLDYIREHKDNIGSQYLLNW------CVQIAK 243 Query: 469 ALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 + YL +++HRD+ N+L+ HVK+ DFGL++L AD H Sbjct: 244 GMNYLEERRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGADEKEYH 290
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 78.6 bits (192), Expect = 1e-14 Identities = 45/143 (31%), Positives = 77/143 (53%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G G FGTV++G V V ++ + + + + F NE+ +L + RH N++ G + Sbjct: 314 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 373 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 ++ ++ +L HLH + D + L + +A +TA + YLHA ++HR Sbjct: 374 -PGFAIITQWCEGSSLYHHLHVADTRF-DMVQL-----IDVARQTAQGMDYLHAKNIIHR 426 Query: 508 DVKTTNILLDGGLHVKVADFGLS 576 D+K+ NI L GL VK+ DFGL+ Sbjct: 427 DLKSNNIFLHEGLTVKIGDFGLA 449
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 78.6 bits (192), Expect = 1e-14 Identities = 45/143 (31%), Positives = 77/143 (53%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G G FGTV++G V V ++ + + + + F NE+ +L + RH N++ G + Sbjct: 314 IGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTR 373 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 ++ ++ +L HLH + D + L + +A +TA + YLHA ++HR Sbjct: 374 -PGFAIITQWCEGSSLYHHLHVADTRF-DMVQL-----IDVARQTAQGMDYLHAKNIIHR 426 Query: 508 DVKTTNILLDGGLHVKVADFGLS 576 D+K+ NI L GL VK+ DFGL+ Sbjct: 427 DLKSNNIFLHEGLTVKIGDFGLA 449
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 78.2 bits (191), Expect = 2e-14 Identities = 50/163 (30%), Positives = 88/163 (53%), Gaps = 2/163 (1%) Frame = +1 Query: 100 YEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILS 279 +++++ + NE+G G FG+V++ VA K L ++S E+F E I+ Sbjct: 210 FQDIEINRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKML-QSSKAEREKFVLEAKIMH 268 Query: 280 RLRHPNLVALYGCTSSCRDL--LLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIA 453 +LRH +V L G + +D+ L++ E++ NG+L ++L D + + + Sbjct: 269 KLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTP-----DGKKTNLNQMVHMM 323 Query: 454 VETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 E + +AYL + +V+HRD++ NIL+ L KVADFGL+ L Sbjct: 324 AEISEGMAYLESEKVVHRDLRADNILVANDLTRKVADFGLTEL 366
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 78.2 bits (191), Expect = 2e-14 Identities = 46/143 (32%), Positives = 70/143 (48%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 +G+G FGTVY+ V + S ++ F NEV +L + RH N++ GC S Sbjct: 435 IGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSK 494 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 L +V ++ +L H+H T + I + A + YLHA ++HR Sbjct: 495 -PSLAIVTQWCEGSSLYKHVHVSET------KFKLNTLIDIGRQVAQGMDYLHAKNIIHR 547 Query: 508 DVKTTNILLDGGLHVKVADFGLS 576 D+K+ NI L L VK+ DFGL+ Sbjct: 548 DLKSNNIFLHEDLSVKIGDFGLA 570
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 78.2 bits (191), Expect = 2e-14 Identities = 62/186 (33%), Positives = 88/186 (47%), Gaps = 4/186 (2%) Frame = +1 Query: 31 GSPLTSLRKEFNLAGSPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGS-VV 207 G LT + L GS FT D F LG G FG VY + +V Sbjct: 54 GQKLTENKGATALQGSQSRQPFTI-------DNFEIGRPLGKGKFGNVYLAREKKSRFIV 106 Query: 208 AVKRLYKNSYK--GVE-QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLA 378 A+K L+K+ + GVE Q E++I + L+HPN++ LY + + L+ E+ P G L Sbjct: 107 ALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELY 166 Query: 379 DHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKV 558 L +G D + I E + AL Y H +V+HRD+K N+LL +K+ Sbjct: 167 KELQ--KSGTFDEQRTAT-----IMEELSDALMYCHKKKVIHRDIKPENLLLGLQGELKI 219 Query: 559 ADFGLS 576 ADFG S Sbjct: 220 ADFGWS 225
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 78.2 bits (191), Expect = 2e-14 Identities = 58/183 (31%), Positives = 88/183 (48%), Gaps = 14/183 (7%) Frame = +1 Query: 88 HIFTYEELDAATDGFGAANE---------LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYK 240 H TYE+ + A F E +GAG FG V G LR S ++ K+ Sbjct: 603 HPHTYEDPNQAVRDFAKEIEVSNIRIERVIGAGEFGEVCSGRLRLPSKREIQVAIKSLKA 662 Query: 241 GVEQ-----FANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAG 405 G + F +E I+ + HPN++ L G + C+ +++V E++ NG+L L + G Sbjct: 663 GYSEHQRRDFLSEASIMGQFDHPNIIRLEGVVTRCKPVMIVTEYMENGSLDTFLKKHD-G 721 Query: 406 GGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 + L LG+ AA + YL +HRD+ NIL++ L KV+DFGLSR+ Sbjct: 722 QFTVIQL-----LGMLRGIAAGMQYLSEMNYVHRDLAARNILVNRNLVCKVSDFGLSRVL 776 Query: 586 PAD 594 D Sbjct: 777 EDD 779
>CDC2H_PLAYO (Q7RM49) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 289 Score = 78.2 bits (191), Expect = 2e-14 Identities = 55/165 (33%), Positives = 83/165 (50%), Gaps = 7/165 (4%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRL-YKNSYKGVEQFAN--EVDILSRLRHPNLVALYG 315 ++G G +G VYK DG A+K++ + +G+ + E+ IL LRH N+V LY Sbjct: 9 KIGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTVSIREISILKELRHSNIVKLYD 68 Query: 316 CTSSCRDLLLVYEFVPNGT--LADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHA 489 + + L+LV+E + L D G L T ++ +AY H Sbjct: 69 VIHAKKRLILVFEHLDQDLKKLIDVCDGG---------LESVTAKSFLLQLLNGIAYCHE 119 Query: 490 HQVLHRDVKTTNILLDGGLHVKVADFGLSRLF--PADGATQHVST 618 H+VLHRD+K N+L++ +K+ADFGL+R F PA T V T Sbjct: 120 HRVLHRDLKPQNLLINREGELKIADFGLARAFGIPARRYTHEVVT 164
>KAPC_DICDI (P34099) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) Length = 648 Score = 78.2 bits (191), Expect = 2e-14 Identities = 51/148 (34%), Positives = 73/148 (49%), Gaps = 4/148 (2%) Frame = +1 Query: 148 LGAGGFGTVYK-GVLRDGSVVAVKRL---YKNSYKGVEQFANEVDILSRLRHPNLVALYG 315 LG G FG VY +DG A+K L Y K VE +E ILS + HP +V LY Sbjct: 342 LGTGTFGKVYLIQNTKDGCYYAMKCLNKAYVVQLKQVEHLNSEKSILSSIHHPFIVNLYQ 401 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 + L L++E+V G + HL + S T A E AL +LH Sbjct: 402 AFQDEKKLYLLFEYVAGGEVFTHLRKS-------MKFSNSTAKFYAAEIVLALEFLHKQN 454 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSR 579 +++RD+K N+L+D H+K+ DFG ++ Sbjct: 455 IVYRDLKPENLLIDNQGHIKITDFGFAK 482
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 78.2 bits (191), Expect = 2e-14 Identities = 48/153 (31%), Positives = 83/153 (54%), Gaps = 9/153 (5%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLY-------KNSYKG-VEQFANEVDILSRLRHPNL 300 +G G FG VY G+ L G ++A+K++ K +G + + EV +L L HPN+ Sbjct: 74 IGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPNI 133 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 V G L ++ EFVP G+++ L + +P+++ + +L + +E Y Sbjct: 134 VRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFP-EPVIIMYTKQLLLGLE------Y 186 Query: 481 LHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 LH + ++HRD+K NIL+D +++ADFG S+ Sbjct: 187 LHNNGIMHRDIKGANILVDNKGCIRLADFGASK 219
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 78.2 bits (191), Expect = 2e-14 Identities = 51/157 (32%), Positives = 83/157 (52%), Gaps = 3/157 (1%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHP 294 + F ++G G +G VYK + G VA+K++ ++ +GV A E+ +L L HP Sbjct: 2 ESFQKVEKIGEGTYGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L+ + L LV+EF+ + L + G +S P + L Sbjct: 62 NIVKLHDVIHTENKLYLVFEFL-HQDLKRFMDSSTVTG-----ISLPLVKSYLFQLLQGL 115 Query: 475 AYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 A+ H+H+VLHRD+K N+L++ +K+ADFGL+R F Sbjct: 116 AFCHSHRVLHRDLKPQNLLINAQGEIKLADFGLARAF 152
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 78.2 bits (191), Expect = 2e-14 Identities = 50/146 (34%), Positives = 75/146 (51%), Gaps = 1/146 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K + G V+ +K L + + + F EV ++ L HPN++ G Sbjct: 337 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 396 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L L+ E++ GTL D L + DP W ++ A A+ +AYLH+ ++H Sbjct: 397 KDKKLNLLTEYIEGGTLKDFLRNA-----DPF--PWQQKVSFAKGIASGMAYLHSMCIIH 449 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD+ + N L+ V VADFGLSRL Sbjct: 450 RDLNSHNCLIKLDKTVVVADFGLSRL 475
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 77.8 bits (190), Expect = 2e-14 Identities = 48/146 (32%), Positives = 75/146 (51%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LGAG FG V+ + VAVK + S VE F E +++ L+H LV L+ S Sbjct: 243 KLGAGQFGEVWMATYNKHTKVAVKTMKPGSMS-VEAFLAEANLMKTLQHDKLVKLHAVVS 301 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G PL P + + + + +A++ +H Sbjct: 302 Q-EPIFIVTEFMAKGSLLDFLK-SEEGSKQPL----PKLIDFSAQISEGMAFIEQRNYIH 355 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L K+ADFGL+R+ Sbjct: 356 RDLRAANILVSASLVCKIADFGLARI 381
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 77.8 bits (190), Expect = 2e-14 Identities = 55/162 (33%), Positives = 76/162 (46%), Gaps = 12/162 (7%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRDGS--VVAVKRLYK-NSYKGVEQFANEVDILSRLRHPNL 300 F + +G G F V+KG R+ VAVK + K N K E+ IL L+H N+ Sbjct: 16 FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENI 75 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 VALY + LV E+ G LAD+LH D + L + A A+ Sbjct: 76 VALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRL-------FLQQIAGAMRL 128 Query: 481 LHAHQVLHRDVKTTNILLD---------GGLHVKVADFGLSR 579 LH+ ++HRD+K NILL + VK+ADFG +R Sbjct: 129 LHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFAR 170
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 77.8 bits (190), Expect = 2e-14 Identities = 48/146 (32%), Positives = 75/146 (51%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LGAG FG V+ + VAVK + S VE F E +++ L+H LV L+ S Sbjct: 264 KLGAGQFGEVWMATYNKHTKVAVKTMKPGSMS-VEAFLAEANLMKSLQHDKLVKLHAVVS 322 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + +V EF+ G+L D L G PL P + + + + +A++ +H Sbjct: 323 Q-EPIFIVTEFMAKGSLLDFLK-SEEGSKQPL----PKLIDFSAQISEGMAFIEQRNYIH 376 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L K+ADFGL+R+ Sbjct: 377 RDLRAANILVSASLVCKIADFGLARI 402
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 77.8 bits (190), Expect = 2e-14 Identities = 53/157 (33%), Positives = 82/157 (52%), Gaps = 3/157 (1%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHP 294 + F ++G G +G VYK + G VVA+K++ ++ +GV A E+ +L L HP Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L + L LV+EF+ +A G PL P + L Sbjct: 62 NIVKLLDVIHTENKLYLVFEFLHQDL--KKFMDASAVTGIPL----PLIKSYLFQLLQGL 115 Query: 475 AYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 A+ H+H+VLHRD+K N+L++ +K+ADFGL+R F Sbjct: 116 AFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAF 152
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 77.8 bits (190), Expect = 2e-14 Identities = 53/157 (33%), Positives = 82/157 (52%), Gaps = 3/157 (1%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHP 294 + F ++G G +G VYK + G VVA+K++ ++ +GV A E+ +L L HP Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L + L LV+EF+ +A G PL P + L Sbjct: 62 NIVKLLDVIHTENKLYLVFEFLHQDL--KKFMDASALTGIPL----PLIKSYLFQLLQGL 115 Query: 475 AYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 A+ H+H+VLHRD+K N+L++ +K+ADFGL+R F Sbjct: 116 AFCHSHRVLHRDLKPQNLLINADGSIKLADFGLARAF 152
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 77.8 bits (190), Expect = 2e-14 Identities = 55/145 (37%), Positives = 74/145 (51%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSS 327 LG G FG V+ G + VAVK L K + F E I+ LRH LV LY S Sbjct: 257 LGTGCFGDVWLGTWNCSTKVAVKTL-KPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSE 315 Query: 328 CRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHR 507 + +V EF+ G+L D L G LML P + +A + A +AY+ +HR Sbjct: 316 -EPIYIVTEFMCYGSLLDFLKDRE---GQNLML--PHLVDMAAQVAEGMAYMERMNYIHR 369 Query: 508 DVKTTNILLDGGLHVKVADFGLSRL 582 D++ NIL+ L K+ADFGL+RL Sbjct: 370 DLRAANILVGEYLICKIADFGLARL 394
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 77.8 bits (190), Expect = 2e-14 Identities = 57/162 (35%), Positives = 78/162 (48%), Gaps = 12/162 (7%) Frame = +1 Query: 130 FGAANELGAGGFGTVYKGVLRDGS--VVAVKRLYK-NSYKGVEQFANEVDILSRLRHPNL 300 F + +G G F V+KG R+ VAVK + K N K E+ IL L+H N+ Sbjct: 16 FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENI 75 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAY 480 VALY + LV E+ G LAD+LH D + L + A A+ Sbjct: 76 VALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRL-------FLQQIAGAMRL 128 Query: 481 LHAHQVLHRDVKTTNILLD--GG-------LHVKVADFGLSR 579 LH+ ++HRD+K NILL GG + VK+ADFG +R Sbjct: 129 LHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFAR 170
>SN1L1_RAT (Q9R1U5) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (Salt-inducible protein kinase) (Protein kinase KID2) Length = 776 Score = 77.8 bits (190), Expect = 2e-14 Identities = 48/150 (32%), Positives = 75/150 (50%), Gaps = 4/150 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSY--KGVEQFANEVDILSRLRHPNLVALYGC 318 LG G F V R + VA+K + K +E+ EV ++ L HPN++ LY Sbjct: 33 LGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQV 92 Query: 319 TSSCRDLLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 + L +V EF NG + D+L +G+ + W + +A+ Y H H Sbjct: 93 METKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFW--------QILSAVEYCHNHH 144 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 ++HRD+KT N+LLDG + +K+ADFG + Sbjct: 145 IVHRDLKTENLLLDGNMDIKLADFGFGNFY 174
>CDKL4_MOUSE (Q3TZA2) Cyclin-dependent kinase-like 4 (EC 2.7.11.22)| Length = 342 Score = 77.8 bits (190), Expect = 2e-14 Identities = 54/162 (33%), Positives = 85/162 (52%), Gaps = 4/162 (2%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQ--FANEVDILSRLRHPNLVALYG 315 ++G G +G V+K + G VVA+K+ ++ V + E+ +L +L+HPNLV L Sbjct: 9 KIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLKHPNLVNLIE 68 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 R + LV+E+ + TL + L G D ++ S + +T AL + H H Sbjct: 69 VFRRKRKMHLVFEYCDH-TLLNELERNPNGVSDGVIKS------VLWQTLQALNFCHKHN 121 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSR-LFPADGATQHVST 618 +HRDVK NIL+ +K+ DFG +R L P D T +V+T Sbjct: 122 CIHRDVKPENILITKQGMIKICDFGFARILIPGDAYTDYVAT 163
>HCK_MACFA (Q95M30) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 503 Score = 77.4 bits (189), Expect = 3e-14 Identities = 47/146 (32%), Positives = 76/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LGAG FG V+ + VAVK + S VE F E +++ L+H LV L+ + Sbjct: 244 KLGAGQFGEVWMATYNKHTKVAVKTMKPGSMS-VEAFLAEANLMKTLQHDKLVKLHAVVT 302 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + ++ EF+ G+L D L + G PL P + + + A +A++ +H Sbjct: 303 K-EPIYIITEFMAKGSLLDFLK-SDEGSKQPL----PKLIDFSAQIAEGMAFIEQRNYIH 356 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L K+ADFGL+R+ Sbjct: 357 RDLRAANILVSASLVCKIADFGLARI 382
>CDKL3_MOUSE (Q8BLF2) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| Length = 595 Score = 77.4 bits (189), Expect = 3e-14 Identities = 54/162 (33%), Positives = 84/162 (51%), Gaps = 4/162 (2%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFAN-EVDILSRLRHPNLVALYGC 318 ++G G +GTV K +D G +VA+K Y+ K V + A E+ L + RH NLV L Sbjct: 9 KVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEV 68 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + + LV+EF+ + T+ D L H G + + ++ A+E YLH + + Sbjct: 69 FRQKKKIHLVFEFIDH-TVLDELQHYCHGLESKRLRKYLFQILRAIE------YLHNNNI 121 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSRLF--PADGATQHVST 618 +HRD+K NIL+ K+ DFG +R P D T +V+T Sbjct: 122 IHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVAT 163
>CDKL3_RAT (Q9JM01) Cyclin-dependent kinase-like 3 (EC 2.7.11.22)| (Serine/threonine protein kinase NKIATRE) Length = 593 Score = 77.4 bits (189), Expect = 3e-14 Identities = 54/162 (33%), Positives = 84/162 (51%), Gaps = 4/162 (2%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFAN-EVDILSRLRHPNLVALYGC 318 ++G G +GTV K +D G +VA+K Y+ K V + A E+ L + RH NLV L Sbjct: 9 KVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEV 68 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + + LV+EF+ + T+ D L H G + + ++ A+E YLH + + Sbjct: 69 FRQKKKIHLVFEFIDH-TVLDELQHYCHGLESKRLRKYLFQILRAIE------YLHNNNI 121 Query: 499 LHRDVKTTNILLDGGLHVKVADFGLSRLF--PADGATQHVST 618 +HRD+K NIL+ K+ DFG +R P D T +V+T Sbjct: 122 IHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVAT 163
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 77.4 bits (189), Expect = 3e-14 Identities = 47/146 (32%), Positives = 76/146 (52%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 +LGAG FG V+ + VAVK + S VE F E +++ L+H LV L+ + Sbjct: 266 KLGAGQFGEVWMATYNKHTKVAVKTMKPGSMS-VEAFLAEANVMKTLQHDKLVKLHAVVT 324 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + ++ EF+ G+L D L + G PL P + + + A +A++ +H Sbjct: 325 K-EPIYIITEFMAKGSLLDFLK-SDEGSKQPL----PKLIDFSAQIAEGMAFIEQRNYIH 378 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD++ NIL+ L K+ADFGL+R+ Sbjct: 379 RDLRAANILVSASLVCKIADFGLARV 404
>CDK2_MOUSE (P97377) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 346 Score = 77.4 bits (189), Expect = 3e-14 Identities = 53/157 (33%), Positives = 82/157 (52%), Gaps = 3/157 (1%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHP 294 + F ++G G +G VYK + G VVA+K++ ++ +GV A E+ +L L HP Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L + L LV+EF+ +A G PL P + L Sbjct: 62 NIVKLLDVIHTENKLYLVFEFLHQDL--KKFMDASALTGIPL----PLIKSYLFQLLQGL 115 Query: 475 AYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 A+ H+H+VLHRD+K N+L++ +K+ADFGL+R F Sbjct: 116 AFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAF 152
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 77.4 bits (189), Expect = 3e-14 Identities = 46/146 (31%), Positives = 75/146 (51%), Gaps = 1/146 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K R+ G V+ +K L + + F EV ++ L HPN++ G Sbjct: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L + E++ GTL + + ++ W R+ A + A+ +AYLH+ ++H Sbjct: 405 KDKRLNFITEYIKGGTLRGIIKNMDS------QYPWSQRVSFAKDIASGMAYLHSMNIIH 458 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD+ + N L+ +V VADFGL+RL Sbjct: 459 RDLNSHNCLVRENRNVVVADFGLARL 484
>XMRK_XIPMA (P13388) Melanoma receptor tyrosine-protein kinase precursor (EC| 2.7.10.1) Length = 1167 Score = 77.0 bits (188), Expect = 4e-14 Identities = 54/156 (34%), Positives = 83/156 (53%), Gaps = 7/156 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGS----VVAVKRLYK-NSYKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ DG VA+K L + S K ++ +E +++ + HP++ L Sbjct: 716 LGSGAFGTVYKGLWNPDGENIRIPVAIKVLREATSPKVNQEVLDEAYVMASVDHPHVCRL 775 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 G C +S + LV + +P G L D++ +L+W V+ A + YL Sbjct: 776 LGICLTSA--VQLVTQLMPYGCLLDYVRQHQERICGQWLLNW------CVQIAKGMNYLE 827 Query: 487 AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 ++HRD+ N+LL HVK+ DFGLS+L AD Sbjct: 828 ERHLVHRDLAARNVLLKNPNHVKITDFGLSKLLTAD 863
>AURKB_HUMAN (Q96GD4) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1) (Aurora-B) Length = 344 Score = 77.0 bits (188), Expect = 4e-14 Identities = 54/155 (34%), Positives = 74/155 (47%), Gaps = 4/155 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRLRH 291 D F LG G FG VY + +VA+K L+K+ + GVE Q E++I + L H Sbjct: 75 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 134 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LY R + L+ E+ P G L L I E A A Sbjct: 135 PNILRLYNYFYDRRRIYLILEYAPRGELYKELQKS-------CTFDEQRTATIMEELADA 187 Query: 472 LAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLS 576 L Y H +V+HRD+K N+LL +K+ADFG S Sbjct: 188 LMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWS 222
>ROR2_MOUSE (Q9Z138) Tyrosine-protein kinase transmembrane receptor ROR2| precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2) Length = 944 Score = 77.0 bits (188), Expect = 4e-14 Identities = 54/168 (32%), Positives = 87/168 (51%), Gaps = 18/168 (10%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGV--EQFANEVDILSRLRHPNL 300 ELG FG VYKG L VA+K L K+ +G E+F E + +RL+HPN+ Sbjct: 478 ELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTL-KDKAEGPLREEFRQEAMLRARLQHPNI 536 Query: 301 VALYGCTSSCRDLLLVYEFVPNGTLADHL----HHGNAGGGDP-----LMLSWPTRLGIA 453 V L G + + L +++ + +G L + L H + G D L P + + Sbjct: 537 VCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHVV 596 Query: 454 VETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR-LFPAD 594 + AA + +L +H V H+D+ T N+L+ L+V+++D GL R ++ AD Sbjct: 597 AQIAAGMEFLSSHHVCHKDLATRNVLVYDKLNVRISDLGLFREVYSAD 644
>SSK2_YEAST (P53599) MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of| sensor kinase 2) Length = 1579 Score = 77.0 bits (188), Expect = 4e-14 Identities = 52/157 (33%), Positives = 78/157 (49%), Gaps = 5/157 (3%) Frame = +1 Query: 142 NELGAGGFGTVYKGV-LRDGSVVAVKRLYKNSYKGVEQF----ANEVDILSRLRHPNLVA 306 N +G G FG VY V L +G ++AVK + K +++ E+ +L L HPN+V+ Sbjct: 1270 NFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLEILNHPNIVS 1329 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 YG + + E+ G+LA L HG D ++ T ++ LAYLH Sbjct: 1330 YYGVEVHRDKVNIFMEYCEGGSLAALLEHGRIE--DEMVTQVYT-----LQLLEGLAYLH 1382 Query: 487 AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 ++HRDVK NILLD +K DFG ++ +G Sbjct: 1383 ESGIVHRDVKPENILLDFNGVIKYVDFGAAKKIANNG 1419
>ERBB3_PONPY (Q5RB22) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) Length = 1342 Score = 77.0 bits (188), Expect = 4e-14 Identities = 53/156 (33%), Positives = 80/156 (51%), Gaps = 7/156 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLYK--NSYKGVEQFANEVD---ILSRLRHPNLVAL 309 LG+G FGTV+KGV + +G + + K G + F D + L H ++V L Sbjct: 715 LGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRL 774 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 G C S L LV +++P G+L DH+ G L+L+W V+ A + YL Sbjct: 775 LGLCPGS--SLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNW------GVQIAKGMYYLE 826 Query: 487 AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 H ++HR++ N+LL V+VADFG++ L P D Sbjct: 827 EHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPD 862
>ERBB3_HUMAN (P21860) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Tyrosine kinase-type cell surface receptor HER3) Length = 1342 Score = 77.0 bits (188), Expect = 4e-14 Identities = 53/156 (33%), Positives = 80/156 (51%), Gaps = 7/156 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLYK--NSYKGVEQFANEVD---ILSRLRHPNLVAL 309 LG+G FGTV+KGV + +G + + K G + F D + L H ++V L Sbjct: 715 LGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRL 774 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 G C S L LV +++P G+L DH+ G L+L+W V+ A + YL Sbjct: 775 LGLCPGS--SLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNW------GVQIAKGMYYLE 826 Query: 487 AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 H ++HR++ N+LL V+VADFG++ L P D Sbjct: 827 EHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPD 862
>CDK2_RAT (Q63699) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 77.0 bits (188), Expect = 4e-14 Identities = 53/157 (33%), Positives = 82/157 (52%), Gaps = 3/157 (1%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSY-KGVEQFA-NEVDILSRLRHP 294 + F ++G G +G VYK + G VVA+K++ ++ +GV A E+ +L L HP Sbjct: 2 ENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 Query: 295 NLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAAL 474 N+V L + L LV+EF+ +A G PL P + L Sbjct: 62 NIVKLLDVIHTENKLYLVFEFLHQDL--KKFMDASALTGLPL----PLIKSYLFQLLQGL 115 Query: 475 AYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 A+ H+H+VLHRD+K N+L++ +K+ADFGL+R F Sbjct: 116 AFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAF 152
>AAPK2_CAEEL (Q95ZQ4) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMP-activated kinase 2) Length = 626 Score = 77.0 bits (188), Expect = 4e-14 Identities = 51/150 (34%), Positives = 75/150 (50%), Gaps = 5/150 (3%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGSV-VAVKRLYKNSYKGVE---QFANEVDILSRLRHPNLVALYG 315 LG G FG V G+ VAVK L + K ++ + E+ LS RHP+++ LY Sbjct: 93 LGVGTFGKVKVGIHETTQYKVAVKILNRQKIKSLDVVGKIRREIQNLSLFRHPHIIRLYQ 152 Query: 316 CTSSCRDLLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAH 492 S+ D+ ++ E V G L D++ HG L + + + Y H H Sbjct: 153 VISTPSDIFMIMEHVSGGELFDYIVKHGR--------LKTAEARRFFQQIISGVDYCHRH 204 Query: 493 QVLHRDVKTTNILLDGGLHVKVADFGLSRL 582 V+HRD+K N+LLD +VK+ADFGLS + Sbjct: 205 MVVHRDLKPENLLLDEQNNVKIADFGLSNI 234
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 77.0 bits (188), Expect = 4e-14 Identities = 50/154 (32%), Positives = 77/154 (50%), Gaps = 4/154 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVE---QFANEVDILSRLRHPNLVALYG 315 LG G FG V G G VAVK L + + ++ + E+ L RHP+++ LY Sbjct: 22 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 S+ D+ +V E+V G L D++ L + + + + Y H H Sbjct: 82 VISTPSDIFMVMEYVSGGELFDYICKNGR-------LDEKESRRLFQQILSGVDYCHRHM 134 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 V+HRD+K N+LLD ++ K+ADFGLS + +DG Sbjct: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMM-SDG 167
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 77.0 bits (188), Expect = 4e-14 Identities = 50/154 (32%), Positives = 77/154 (50%), Gaps = 4/154 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVE---QFANEVDILSRLRHPNLVALYG 315 LG G FG V G G VAVK L + + ++ + E+ L RHP+++ LY Sbjct: 22 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 S+ D+ +V E+V G L D++ L + + + + Y H H Sbjct: 82 VISTPSDIFMVMEYVSGGELFDYICKNGR-------LDEKESRRLFQQILSGVDYCHRHM 134 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 V+HRD+K N+LLD ++ K+ADFGLS + +DG Sbjct: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMM-SDG 167
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 77.0 bits (188), Expect = 4e-14 Identities = 49/154 (31%), Positives = 73/154 (47%), Gaps = 4/154 (2%) Frame = +1 Query: 130 FGAANELGAGGFGTVYK-GVLRDGSVVAVKRLYKNSY---KGVEQFANEVDILSRLRHPN 297 F LG G FG V+ + +G A+K L K K VE +E +L + HP Sbjct: 70 FQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPF 129 Query: 298 LVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALA 477 L+ ++G R++ +V +++ G L L P A E AL Sbjct: 130 LIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPN-------PVAKFYAAEVILALE 182 Query: 478 YLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 YLHAH +++RD+K NILLD H+K+ DFG ++ Sbjct: 183 YLHAHNIIYRDLKPENILLDRNGHIKITDFGFAK 216
>SN1L2_PONPY (Q5REX1) Serine/threonine-protein kinase SNF1-like kinase 2 (EC| 2.7.11.1) Length = 925 Score = 77.0 bits (188), Expect = 4e-14 Identities = 48/150 (32%), Positives = 75/150 (50%), Gaps = 4/150 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGV--EQFANEVDILSRLRHPNLVALYGC 318 LG G F V G R + VA+K + K+ V E+ EV I+ L HP+++ LY Sbjct: 26 LGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQV 85 Query: 319 TSSCRDLLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 + L LV E+ NG + D+L +HG + W + +A+ Y H + Sbjct: 86 METKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFW--------QILSAVDYCHGRK 137 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLF 585 ++HRD+K N+LLD +++K+ADF F Sbjct: 138 IVHRDLKAENLLLDNNMNIKIADFSFGNFF 167
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 77.0 bits (188), Expect = 4e-14 Identities = 49/154 (31%), Positives = 77/154 (50%), Gaps = 1/154 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K R+ G V+ +K L + + F EV ++ L HPN++ G Sbjct: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L + E++ GTL + ++ W R+ A + A+ +AYLH+ ++H Sbjct: 405 KDKRLNFITEYIKGGTLRGIIKSMDS------QYPWSQRVSFAKDIASGMAYLHSMNIIH 458 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRLFPADGATQ 606 RD+ + N L+ +V VADFGL+RL D TQ Sbjct: 459 RDLNSHNCLVRENKNVVVADFGLARLM-VDEKTQ 491
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 77.0 bits (188), Expect = 4e-14 Identities = 50/154 (32%), Positives = 77/154 (50%), Gaps = 4/154 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVE---QFANEVDILSRLRHPNLVALYG 315 LG G FG V G G VAVK L + + ++ + E+ L RHP+++ LY Sbjct: 24 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 83 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 S+ D+ +V E+V G L D++ L + + + + Y H H Sbjct: 84 VISTPSDIFMVMEYVSGGELFDYICKNGR-------LDEKESRRLFQQILSGVDYCHRHM 136 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 V+HRD+K N+LLD ++ K+ADFGLS + +DG Sbjct: 137 VVHRDLKPENVLLDAHMNAKIADFGLSNMM-SDG 169
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 77.0 bits (188), Expect = 4e-14 Identities = 50/154 (32%), Positives = 77/154 (50%), Gaps = 4/154 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVE---QFANEVDILSRLRHPNLVALYG 315 LG G FG V G G VAVK L + + ++ + E+ L RHP+++ LY Sbjct: 24 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 83 Query: 316 CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 S+ D+ +V E+V G L D++ L + + + + Y H H Sbjct: 84 VISTPSDIFMVMEYVSGGELFDYICKNGR-------LDEKESRRLFQQILSGVDYCHRHM 136 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLFPADG 597 V+HRD+K N+LLD ++ K+ADFGLS + +DG Sbjct: 137 VVHRDLKPENVLLDAHMNAKIADFGLSNMM-SDG 169
>SN1L1_MOUSE (Q60670) Serine/threonine-protein kinase SNF1-like kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1-like kinase) Length = 779 Score = 76.6 bits (187), Expect = 5e-14 Identities = 50/164 (30%), Positives = 80/164 (48%), Gaps = 5/164 (3%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSY--KGVEQFANEVDILSRLRHPNLVALYGC 318 LG G F V R + VA+K + K +E+ EV ++ L HPN++ LY Sbjct: 33 LGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQV 92 Query: 319 TSSCRDLLLVYEFVPNGTLADHL-HHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQ 495 + L +V EF NG + D+L +G+ + W + +A+ Y H H Sbjct: 93 METKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFW--------QILSAVEYCHNHH 144 Query: 496 VLHRDVKTTNILLDGGLHVKVADFGLSRLF-PADGATQHVSTAP 624 ++HRD+KT N+LLD + +K+ADFG + P + + V + P Sbjct: 145 IVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTCVGSPP 188
>ERBB3_MOUSE (Q61526) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) (Glial growth factor receptor) Length = 1339 Score = 76.6 bits (187), Expect = 5e-14 Identities = 52/156 (33%), Positives = 80/156 (51%), Gaps = 7/156 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLYK--NSYKGVEQFANEVD---ILSRLRHPNLVAL 309 LG+G FGTV+KG+ + +G + + K G + F D + L H ++V L Sbjct: 713 LGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRL 772 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 G C S L LV +++P G+L DH+ G L+L+W V+ A + YL Sbjct: 773 LGLCPGS--SLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNW------GVQIAKGMYYLE 824 Query: 487 AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 H ++HRD+ N++L V+VADFG++ L P D Sbjct: 825 EHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPD 860
>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never| in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a) Length = 692 Score = 76.6 bits (187), Expect = 5e-14 Identities = 52/163 (31%), Positives = 82/163 (50%), Gaps = 4/163 (2%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFA--NEVDILSRLRHPNLVALYGC 318 +G G FG V+ + + D +V +K++ E+ A NE +L L HPN++ Y Sbjct: 10 VGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYEN 69 Query: 319 TSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQV 498 + L++ E+ P GTLA+ + +L T L V+ AL ++H H + Sbjct: 70 FLEDKALMIAMEYAPGGTLAEFIQKRCNS-----LLEEETILHFFVQILLALHHVHTHLI 124 Query: 499 LHRDVKTTNILLD-GGLHVKVADFGLSRLFPADGATQHVSTAP 624 LHRD+KT NILLD + VK+ DFG+S++ + V P Sbjct: 125 LHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTP 167
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 76.6 bits (187), Expect = 5e-14 Identities = 53/182 (29%), Positives = 87/182 (47%), Gaps = 2/182 (1%) Frame = +1 Query: 40 LTSLRKEFNLAG--SPCTHIFTYEELDAATDGFGAANELGAGGFGTVYKGVLRDGSVVAV 213 +T LR + G +P T F+Y++ + ELG+G FG V G R VA+ Sbjct: 337 VTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAI 396 Query: 214 KRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHH 393 K + + + E F E ++ +L HP LV LYG + + + +V EF+ G L + L Sbjct: 397 KAIREGAMCE-EDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ 455 Query: 394 GNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGL 573 ++LS + + + YL + +HRD+ N L++ VKV+DFG+ Sbjct: 456 RQGHFSRDMLLS------MCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGM 509 Query: 574 SR 579 +R Sbjct: 510 AR 511
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 76.6 bits (187), Expect = 5e-14 Identities = 46/146 (31%), Positives = 74/146 (50%), Gaps = 1/146 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K R+ G V+ +K L + + F EV ++ L HPN++ G Sbjct: 345 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 404 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L + E++ GTL + ++ W R+ A + A+ +AYLH+ ++H Sbjct: 405 KDKRLNFITEYIKGGTLRGIIKSMDS------QYPWSQRVSFAKDIASGMAYLHSMNIIH 458 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD+ + N L+ +V VADFGL+RL Sbjct: 459 RDLNSHNCLVRENRNVVVADFGLARL 484
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 76.3 bits (186), Expect = 7e-14 Identities = 50/146 (34%), Positives = 75/146 (51%), Gaps = 1/146 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K + G V+ +K L + + + F EV ++ L HPN++ G Sbjct: 337 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 396 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L L+ E++ GTL D L + DP W ++ A A+ +AYLH+ ++H Sbjct: 397 KDKKLNLLTEYIEGGTLKDFLRNV-----DPF--PWQQKVRFAKGIASGMAYLHSMCIIH 449 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD+ + N L+ V VADFGLSRL Sbjct: 450 RDLNSHNCLIKLDKTVVVADFGLSRL 475
>EGFR_MOUSE (Q01279) Epidermal growth factor receptor precursor (EC 2.7.10.1)| Length = 1210 Score = 76.3 bits (186), Expect = 7e-14 Identities = 50/161 (31%), Positives = 87/161 (54%), Gaps = 7/161 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVV----AVKRLYK-NSYKGVEQFANEVDILSRLRHPNLVAL 309 LG+G FGTVYKG+ + +G V A+K L + S K ++ +E +++ + +P++ L Sbjct: 720 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL 779 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 G C +S + L+ + +P G L D++ G +L+W V+ A + YL Sbjct: 780 LGICLTST--VQLITQLMPYGCLLDYVREHKDNIGSQYLLNW------CVQIAKGMNYLE 831 Query: 487 AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPADGATQH 609 +++HRD+ N+L+ HVK+ DFGL++L A+ H Sbjct: 832 DRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYH 872
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 76.3 bits (186), Expect = 7e-14 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 15/160 (9%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + + F E ++L+ L+H ++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGNAG----GGDPLM----LSWPTRLGIAVE 459 YG L++V+E++ +G L L HG G P L L IA + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 460 TAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 A+ + YL + +HRD+ T N L+ L VK+ DFG+SR Sbjct: 663 IASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSR 702
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 76.3 bits (186), Expect = 7e-14 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 15/160 (9%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + + F E ++L+ L+H ++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGNAG----GGDPLM----LSWPTRLGIAVE 459 YG L++V+E++ +G L L HG G P L L IA + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 460 TAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 A+ + YL + +HRD+ T N L+ L VK+ DFG+SR Sbjct: 663 IASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSR 702
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 76.3 bits (186), Expect = 7e-14 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 15/160 (9%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + + F E ++L+ L+H ++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGNAG----GGDPLM----LSWPTRLGIAVE 459 YG L++V+E++ +G L L HG G P L L IA + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 460 TAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 A+ + YL + +HRD+ T N L+ L VK+ DFG+SR Sbjct: 663 IASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSR 702
>ERBB3_RAT (Q62799) Receptor tyrosine-protein kinase erbB-3 precursor (EC| 2.7.10.1) (c-erbB3) Length = 1339 Score = 76.3 bits (186), Expect = 7e-14 Identities = 52/156 (33%), Positives = 80/156 (51%), Gaps = 7/156 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGV-LRDGSVVAVKRLYK--NSYKGVEQFANEVD---ILSRLRHPNLVAL 309 LG+G FGTV+KG+ + +G + + K G + F D + L H ++V L Sbjct: 713 LGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRL 772 Query: 310 YG-CTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 G C S L LV +++P G+L DH+ G L+L+W V+ A + YL Sbjct: 773 LGLCPGS--SLQLVTQYLPLGSLLDHVKQHRETLGPQLLLNW------GVQIAKGMYYLE 824 Query: 487 AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 H ++HRD+ N++L V+VADFG++ L P D Sbjct: 825 EHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPD 860
>AL2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22)| (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) Length = 384 Score = 76.3 bits (186), Expect = 7e-14 Identities = 57/158 (36%), Positives = 88/158 (55%), Gaps = 8/158 (5%) Frame = +1 Query: 130 FGAAN------ELGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFA-NEVDILSRL 285 FGAA+ +LG G + TVYKG+ R +G +VA+K + N+ +GV A E +L L Sbjct: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105 Query: 286 RHPNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETA 465 +H N+V L+ + L V+E++ + LA ++ + GG P + RL + Sbjct: 106 KHANIVLLHDIIHTKETLTFVFEYM-HTDLAQYMSQ-HPGGLHPHNV----RL-FMFQLL 158 Query: 466 AALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 LAY+H VLHRD+K N+L+ +K+ADFGL+R Sbjct: 159 RGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLAR 196
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 76.3 bits (186), Expect = 7e-14 Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 15/160 (9%) Frame = +1 Query: 145 ELGAGGFGTVYKGVL------RDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVA 306 ELG G FG V+ +D +VAVK L + + F E ++L+ L+H ++V Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 602 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLH-HGNAG----GGDPLM----LSWPTRLGIAVE 459 YG L++V+E++ +G L L HG G P L L IA + Sbjct: 603 FYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQ 662 Query: 460 TAAALAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLSR 579 A+ + YL + +HRD+ T N L+ L VK+ DFG+SR Sbjct: 663 IASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSR 702
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 76.3 bits (186), Expect = 7e-14 Identities = 54/156 (34%), Positives = 81/156 (51%), Gaps = 7/156 (4%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRDGS-----VVAVKRLYKNSYKGVEQ--FANEVDILSRLRHPNLVA 306 +GAG FG VYKG+L+ S VA+K L K Y ++ F E I+ + H N++ Sbjct: 619 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTL-KAGYTEKQRVDFLGEAGIMGQFSHHNIIR 677 Query: 307 LYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLH 486 L G S + ++++ E++ NG L L + G L L +G+ AA + YL Sbjct: 678 LEGVISKYKPMMIITEYMENGALDKFLREKD-GEFSVLQL-----VGMLRGIAAGMKYLA 731 Query: 487 AHQVLHRDVKTTNILLDGGLHVKVADFGLSRLFPAD 594 +HRD+ NIL++ L KV+DFGLSR+ D Sbjct: 732 NMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD 767
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 76.3 bits (186), Expect = 7e-14 Identities = 52/155 (33%), Positives = 75/155 (48%), Gaps = 4/155 (2%) Frame = +1 Query: 124 DGFGAANELGAGGFGTVYKGVLRDGS-VVAVKRLYKNSYK--GVE-QFANEVDILSRLRH 291 D F LG G FG VY + +VA+K L+K+ + GVE Q E++I + L+H Sbjct: 80 DNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKH 139 Query: 292 PNLVALYGCTSSCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAA 471 PN++ LY + + L+ E+ P G L L I E + A Sbjct: 140 PNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSRT-------FDEQRTATIMEELSDA 192 Query: 472 LAYLHAHQVLHRDVKTTNILLDGGLHVKVADFGLS 576 L Y H +V+HRD+K N+LL +K+ADFG S Sbjct: 193 LTYCHKKKVIHRDIKPENLLLGLQGELKIADFGWS 227
>KIN10_ARATH (Q38997) SNF1-related protein kinase catalytic alpha subunit KIN10| (EC 2.7.11.1) (AKIN10) (AKIN alpha2) Length = 535 Score = 76.3 bits (186), Expect = 7e-14 Identities = 57/190 (30%), Positives = 84/190 (44%), Gaps = 15/190 (7%) Frame = +1 Query: 58 EFNLAGSPCTHIFTYEELDAATDGFGAANE-----------LGAGGFGTVYKGV-LRDGS 201 EFNL S H +D + G + E LG G FG V G Sbjct: 7 EFNLVSSTIDHRIFKSRMDGSGTGSRSGVESILPNYKLGRTLGIGSFGRVKIAEHALTGH 66 Query: 202 VVAVKRLYKNSYKGVE---QFANEVDILSRLRHPNLVALYGCTSSCRDLLLVYEFVPNGT 372 VA+K L + K +E + E+ IL HP+++ LY + D+ LV E+V +G Sbjct: 67 KVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPHIIRLYEVIETPTDIYLVMEYVNSGE 126 Query: 373 LADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLHRDVKTTNILLDGGLHV 552 L D++ L + + + Y H + V+HRD+K N+LLD +V Sbjct: 127 LFDYIVEKGR-------LQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKCNV 179 Query: 553 KVADFGLSRL 582 K+ADFGLS + Sbjct: 180 KIADFGLSNI 189
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 75.9 bits (185), Expect = 9e-14 Identities = 47/146 (32%), Positives = 73/146 (50%), Gaps = 1/146 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLRD-GSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K R+ G V+ +K L + + F EV ++ L HPN++ G Sbjct: 352 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 411 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L + E++ GTL + ++ W R+ A + AA +AYLH+ ++H Sbjct: 412 KEKRLNFITEYIKGGTLRGLIKSMDSH------YPWSQRVSFAKDIAAGMAYLHSMNIIH 465 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD+ + N L+ V VADFGL+RL Sbjct: 466 RDLNSHNCLVRENKSVVVADFGLARL 491
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 75.9 bits (185), Expect = 9e-14 Identities = 50/146 (34%), Positives = 74/146 (50%), Gaps = 1/146 (0%) Frame = +1 Query: 148 LGAGGFGTVYKGVLR-DGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 LG G FG K + G V+ +K L + + + F EV ++ L HPN++ G Sbjct: 337 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 396 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 + L L+ E++ GTL D L DP W ++ A A+ +AYLH+ ++H Sbjct: 397 KDKKLNLLTEYIEGGTLKDFLR-----SMDPF--PWQQKVRFAKGIASGMAYLHSMCIIH 449 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRL 582 RD+ + N L+ V VADFGLSRL Sbjct: 450 RDLNSHNCLIKLDKTVVVADFGLSRL 475
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 75.9 bits (185), Expect = 9e-14 Identities = 51/158 (32%), Positives = 76/158 (48%) Frame = +1 Query: 145 ELGAGGFGTVYKGVLRDGSVVAVKRLYKNSYKGVEQFANEVDILSRLRHPNLVALYGCTS 324 ELG G FG V G R VA+K + + S ++F E ++ L H LV LYG + Sbjct: 406 ELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSE-DEFIEEAKVMMNLSHEKLVQLYGVCT 464 Query: 325 SCRDLLLVYEFVPNGTLADHLHHGNAGGGDPLMLSWPTRLGIAVETAAALAYLHAHQVLH 504 R + ++ E++ NG L ++L +L + + A+ YL + Q LH Sbjct: 465 KQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLE------MCKDVCEAMEYLESKQFLH 518 Query: 505 RDVKTTNILLDGGLHVKVADFGLSRLFPADGATQHVST 618 RD+ N L++ VKV+DFGLSR D T V + Sbjct: 519 RDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGS 556 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 64,555,384 Number of Sequences: 219361 Number of extensions: 1251471 Number of successful extensions: 9250 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 7276 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7859 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5767334219 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
